title: En face enhanced depth imaging optical coherence tomography features in adult onset foveomacular vitelliform dystrophy.
abstract: BACKGROUND
  Our purpose was to describe the different morphological features in adult onset foveomacular vitelliform dystrophy (AOFVD), using en face enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Thirty eyes of 22 consecutive patients presenting with diagnosis of AOFVD were enrolled. Diagnosis of AOFVD was concluded based on fundus examination, autofluorescence imaging, fluorescein angiography and SD-OCT. En face OCT imaging was obtained with the Spectralis EDI SD-OCT; 97 inverted sections (nine averaged B-scans per image) were acquired.
  
  
  RESULTS
  On en face OCT, vitelliform lesions appeared as regular concentric rings of different reflectivity. From the periphery to center of the ring, we observed: (1) the hypereflective ring representing the inner segment/ outer segment (IS/OS) junction, which was continuous in 23 out of 30 eyes, and (2) a well-detectable hyporeflective ring between the IS/OS junction and vitelliform material in 20 out of 30 eyes; the innermost composant of the lesion was hypereflective, and it corresponded to vitelliform material. In eight out of 30 eyes, a hyporeflective "croissant"-shaped lesion with inferior concavity in the upper part of the hyperreflective material was present. Hypereflective retinal pigment epithelium (RPE) elevations or bumps were detected in 25 out of 30 eyes. These areas of focal RPE thickening or bumps appeared to be intensely hypereflective on infrared reflectance imaging.
  
  
  CONCLUSIONS
  En face imaging of the retina helps visualizing the distribution of vitelliform material in AOFVD. The sedimentation of vitelliform lesions is characterized by a upper "croissant"-shaped hypoflectivity. The bumps/thickening of RPE appeared as hypereflective lesions on IR imaging.
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Puche
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Rocio
authors.initials: R
authors.lastname: Blanco-Garavito
authors.forename: Jennyfer
authors.initials: J
authors.lastname: Zerbib
authors.forename: Farah
authors.initials: F
authors.lastname: Gherdaoui
authors.forename: Julien
authors.initials: J
authors.lastname: Tilleul
authors.forename: Florence
authors.initials: F
authors.lastname: Coscas
authors.forename: Agnes
authors.initials: A
authors.lastname: Glacet-Bernard
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008297:Male; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology; D057826:Vitelliform Macular Dystrophy / Q000175:diagnosis*