title: [Membrane-bound cytokine and feedforward regulation].
abstract: Feedback and feedforward widely exist in life system, both of them are the basic processes of control system. While the concept of feedback has been widely used in life science, feedforward regulation was systematically studied in neurophysiology, awaiting further evidence and mechanism in molecular biology and cell biology. The authors put forward a hypothesis about the feedforward regulation of membrane bound macrophage colony stimulation factor (mM-CSF) on the basis of their previous work. This hypothesis might provide a new direction for the study on the biological effects of mM-CSF on leukemia and solid tumors, and contribute to the study on other membrane bound cytokines.
authors.affiliation: State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin 300020, China. E-mail:hiwukefu@163.com.
authors.forename: Ke-Fu
authors.initials: KF
authors.lastname: Wu
authors.forename: Guo-Guang
authors.initials: GG
authors.lastname: Zheng
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Ma
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Song
mesh_terms: D025461:Feedback, Physiological; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006801:Humans; D007938:Leukemia; D049490:Systems Biology
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor