title: [Mineral and bone disorders in renal transplantation].
abstract: The deregulation of bone and mineral metabolism during chronic kidney disease (CKD) is a daily challenge for physicians, its management aiming at decreasing the risk of both fractures and vascular calcifications. Renal transplantation in the context of CKD, with pre-existing renal osteodystrophy as well as nutritional impairment, chronic inflammation, hypogonadism and corticosteroids exposure, represents a major risk factor for bone impairment in the post-transplant period. The aim of this review is therefore to provide an update on the pathophysiology of mineral and bone disorders after renal transplantation.
authors.affiliation: Centre de référence des maladies rénales rares, service de néphrologie et rhumatologie pédiatriques, hôpital Femme-Mère-Enfant, boulevard Pinel, 69677 Bron cedex, France; Institut de génomique fonctionnelle de Lyon (IGFL), École normale supérieure, 69007 Lyon, France; Université de Lyon, 69008 Lyon, France. Electronic address: justine.bacchetta@chu-lyon.fr.
authors.forename: Justine
authors.initials: J
authors.lastname: Bacchetta
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Lafage-Proust
authors.forename: Roland
authors.initials: R
authors.lastname: Chapurlat
mesh_terms: D001847:Bone Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D001842:Bone and Bones / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008903:Minerals / Q000378:metabolism; D010760:Phosphorus Metabolism Disorders / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors
chemical_list: C000717427:FGF23 protein, human; D008903:Minerals; D000089703:Fibroblast Growth Factor-23
keywords: Bone; CKD-MBD; FGF23; Mineral metabolism; Os; PTH; Renal transplantation; Transplantation rénale