title: Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension.
abstract: The Indian Kudzu (Pueraria tuberosa DC.) is an important medicinal plant widely used in Indian and Chinese traditional systems of medicine. The present study is an attempt to evaluate effect of its tubers on blood pressure, coagulation parameters and antioxidant status in patients with stage 1 (primary) hypertension. In a long-term, single blinded, placebo controlled study; 15 patients with stage 1 hypertension (group 1), were administered 3 g P. tuberosa in two divided doses while another 15 patients (group II) were administered matched placebo for a period of twelve weeks. A significant fall of 25, 11 and 16 mmHg was observed in systolic (p < 0.001), diastolic (p < 0.05) and mean (p < 0.001) blood pressure, respectively at the end of the study. Along with blood pressure reduction, there was a significant (p < 0.01) reduction in plasma fibrinogen and significant enhancement of plasma fibrinolytic activity (p < 0.001) and serum total antioxidant status (p < 0.05). It was tolerated well without any untoward side effects.
authors.affiliation: Indigenous Drug Research Center, Department of Medicine, RNT Medical College, Udaipur-313001, Rajasthan, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Verma
authors.forename: Vartika
authors.initials: V
authors.lastname: Jain
authors.forename: D P
authors.initials: DP
authors.lastname: Singh
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007529:Isoflavones / Q000494:pharmacology; D008875:Middle Aged; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D029908:Pueraria / Q000737:chemistry*; D016037:Single-Blind Method
chemical_list: D000959:Antihypertensive Agents; D000975:Antioxidants; D007529:Isoflavones; D010936:Plant Extracts