title: Asymmetric synthesis of α-alkenyl homoallylic primary amines via 1,2-addition of Grignard reagent to α,β-unsaturated phosphonyl imines.
abstract: A series of chiralN-phosphonyl protected α-alkenyl homoallylic primary amines were synthesized by asymmetric addition of allylmagnesium bromide Grignard reagent towards chiral α,β-unsaturated imines. Only 1,2-adduct was obtained for all the imines with good yields and excellent diastereoselectivities. The chiral auxiliary could be easily removed under simple conditions, giving free multiple functionalized primary amines.
authors.affiliation: School of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Xiong
authors.forename: Haibo
authors.initials: H
authors.lastname: Mei
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan