title: Association of XRCC1 Arg399Gln polymorphism with bladder cancer susceptibility: a meta-analysis.
abstract: Genetic variations in DNA repair genes are thought to modify DNA repair capacity and may to be related to cancer susceptibility. However, epidemiological study results have been inconsistent. In this meta-analysis, we assessed 24 case-control studies of association between the X-ray repair cross complementing group 1 (XRCC1) Arg399Gln polymorphism and bladder cancer susceptibility in the general population and in Asian and non-Asian subgroups. A moderately significant association with bladder cancer risk was found for AG vs GG (OR=1.110, 95% CI=1.018-1.210). No significant associations with bladder cancer risk were found for AA vs GG (OR=0.942, 95% CI=0.823-1.077), the dominant model AA/AG vs GG (OR=1.075, 95% CI=0.990-1.167) and the recessive model AA vs AG/GG(OR=0.890, 95% CI=0.788-1.005). In subgroup analysis, a moderately significant association was also found for AG vs GG (OR=1.091, 95% CI=1.008-1.180) in non-Asian subgroup. The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population.
authors.affiliation: Department of Urology, the First People's Hospital of Yueyang, PR China. Electronic address: dengfengyang83@163.com.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Yang
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Du
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yin
authors.forename: Yajie
authors.initials: Y
authors.lastname: Wang
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014571:Urologic Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
keywords: Bladder cancer; CI; HWE; Hardy–Weinberg equilibrium; Meta-analysis; OR; Polymorphism; X-ray repair cross-complementing group 1; XRCC1; XRCC1 Arg399Gln; confidence interval; odds ratio