title: An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(II) ions.
abstract: An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu(2+) was synthesized and used for fluorescence imaging in HeLa cells. The probe was specifically localized in lysosomes and successfully applied to visualize Cu(2+) as well as to monitor Cu(2+) level changes in the lysosomes of living cells.
authors.affiliation: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. wangzl@nju.edu.cn gengzr@nju.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ma
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jinghan
authors.initials: J
authors.lastname: Wen
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Geng
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D002413:Cations, Divalent / Q000032:analysis; D003300:Copper / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008247:Lysosomes / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry; D061848:Optical Imaging / Q000379:methods; D010069:Oxadiazoles / Q000737:chemistry*
chemical_list: C526864:7-nitrobenz-2-oxa-1,3-diazole; D002413:Cations, Divalent; D005456:Fluorescent Dyes; D047028:Macrocyclic Compounds; D010069:Oxadiazoles; D003300:Copper