title: Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children.
abstract: BACKGROUND
  Plasma adipocytokines are associated with metabolic profile and cardiovascular risk in obese children.
  
  
  OBJECTIVE
  To investigate the association of plasma leptin and adiponectin concentrations with cardiometabolic risk profile and systemic inflammation in non-obese children.
  
  
  METHODS
  We studied 170 healthy, non-obese children (86 males, mean age 10±2 years).
  
  
  METHODS
  Children's current body mass index (BMI), plasma leptin and adiponectin concentrations, lipid profile, fasting plasma glucose and high sensitivity C reactive protein (hsCRP) were measured.
  
  
  RESULTS
  After adjustment for age, gender and BMI, plasma leptin concentrations were positively associated with hsCRP (t=2.72, p=0.009) and fasting plasma glucose (t=4.27, p<0.0001); plasma adiponectin concentrations were negatively associated with hsCRP (t=-3.31, p=0.0016); and positively with high density lipoprotein cholesterol (t=2.32, p=0.02). Children in the highest quartile of leptin/adiponectin (L/A) ratio demonstrated significantly higher BMI, systolic blood pressure, hsCRP, triglycerides and fasting glucose and the lowest high density lipoprotein (HDL) compared to lower L/A ratio quartiles.
  
  
  CONCLUSIONS
  Alterations in plasma leptin and adiponectin may help to reclassify non-obese children, detecting those with more unfavorable risk profiles independent of BMI status.
authors.forename: Dimitrios A
authors.initials: DA
authors.lastname: Stakos
authors.forename: Helena I
authors.initials: HI
authors.lastname: Papaioannou
authors.forename: Iliana
authors.initials: I
authors.lastname: Angelidou
authors.forename: Elpis
authors.initials: E
authors.lastname: Mantadakis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Paraskakis
authors.forename: Christina
authors.initials: C
authors.lastname: Tsigalou
authors.forename: Athanasios
authors.initials: A
authors.lastname: Chatzimichael
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008659:Metabolic Diseases / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin