title: Embryonic stem cell-specific signature in cervical cancer.
abstract: The wide range of invasive and noninvasive lesion phenotypes associated with high-risk human papillomavirus (HR-HPV) infection in cervical cancer (CC) indicates that not only the virus but also specific cervical epithelial cells in the transformation zone (TZ), such as stem cells (SCs), play an important part in the development of cervical neoplasia. In this review, we focused in an expression signature that is specific to embryonic SCs and to poorly differentiated cervical malignant tumors and we hypothesize that this expression signature may play an important role to promote cell growth, survival, colony formation, lack of adhesion, as well as cell invasion and migration in CC.
authors.affiliation: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), México, DF, México, nava_organista@yahoo.com.mx.
authors.forename: Jorge
authors.initials: J
authors.lastname: Organista-Nava
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Gómez-Gómez
authors.forename: Patricio
authors.initials: P
authors.lastname: Gariglio
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D053595:Embryonic Stem Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D059467:Transcriptome / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology