title: Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines.
abstract: Direct catalytic addition of acetonitrile pronucleophiles to thiophosphinoylimines is described. Soft Lewis acid-hard Brønsted base cooperative catalysis is crucial to promote this elusive carbon-carbon bond-forming reaction in an enantioselective fashion.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. nkumagai@bikaken.or.jp mshibasa@bikaken.or.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawato
authors.forename: Naoya
authors.initials: N
authors.lastname: Kumagai
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D058116:Lewis Acids; D013854:Thioamides; D003300:Copper; C032159:acetonitrile