title: Massive splenomegaly and lymphopenia: a unique case of obstructive shock.
abstract: We present a patient with intravascular large B-cell lymphoma (IVLBCL)-induced obstructive shock. This case represents a unique presentation of the disease, while highlighting the difficulty of establishing the diagnosis. Although there was a high clinical suspicion for a lymphomatous process, the obstructive shock component of the patient's presentation was perplexing. It was not until the autopsy reports demonstrated lymphocytes within the pulmonary vasculature that the clinical picture of altered mental status, weight loss and obstructive shock were unified to the diagnosis of intravascular large B-cell lymphoma.
authors.affiliation: Department of Internal Medicine, Madigan Army Medical Center, Tacoma, Washington, USA.
authors.forename: Nikhil Anand
authors.initials: NA
authors.lastname: Huprikar
authors.forename: Maria T
authors.initials: MT
authors.lastname: Kurtz
authors.forename: Cristin A
authors.initials: CA
authors.lastname: Mount
mesh_terms: D001344:Autopsy; D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology*; D008231:Lymphopenia / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D010808:Physical Examination / Q000379:methods; D012720:Severity of Illness Index; D012769:Shock / Q000209:etiology* / Q000473:pathology*; D013156:Splenectomy / Q000379:methods; D013163:Splenomegaly / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000473:pathology*