title: Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population.
abstract: Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylori-specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42-4.55) for IM and 2.38 (95% CI = 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27-6.59) and 2.20 (95% CI = 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p(for) trend = 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Pan
authors.forename: Luca
authors.initials: L
authors.lastname: Formichella
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Ma
authors.forename: Zhe-Xuan
authors.initials: ZX
authors.lastname: Li
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Wang
authors.forename: Gereon
authors.initials: G
authors.lastname: Goettner
authors.forename: Kurt
authors.initials: K
authors.lastname: Ulm
authors.forename: Meinhard
authors.initials: M
authors.lastname: Classen
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: You
authors.forename: Markus
authors.initials: M
authors.lastname: Gerhard
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D044466:Asian People; D001426:Bacterial Proteins / Q000276:immunology; D018834:Chaperonin 60 / Q000276:immunology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D011230:Precancerous Conditions / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D018834:Chaperonin 60; C080866:cagA protein, Helicobacter pylori
keywords: Helicobacter pylori; gastric cancer; precancerous gastric lesions; protein; serology