title: Isolated hepatic perfusion for metastatic melanoma.
abstract: Unresectable hepatic metastases from melanoma present a challenge to the physician. Although there have been advances in systemic therapies for patients with metastatic cutaneous melanoma to the liver, the overall prognosis is poor and is worse in patients with metastatic ocular melanoma. Isolated hepatic perfusion, open or percutaneous, allows high doses of cytotoxic chemotherapy to be delivered directly to the liver while minimizing systemic exposure, and has emerged as a viable treatment options for these complex patients.
authors.affiliation: Department of Cutaneous Oncology, H. Lee Moffitt Comprehensive Cancer Center, Tampa, Florida.
authors.forename: Maki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Zager
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000556:secondary*; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents
keywords: isolated hepatic perfusion; melphalan; percutaneous hepatic perfusion