title: Potassium isopropoxide: for sulfination it is the only base you need!
abstract: PEPPSI max: KOiPr has been identified as the key ingredient for Pd-catalyzed sulfination. Potassium is essential to keep the thiol concentration low, and isopropoxide is necessary for precatalyst activation and to break up Pd-sufide-based resting states. Together with the reactive Pd-PEPPSI-IPent(Cl) o-picoline catalyst, this system couples profoundly deactivated partners at RT that other catalysts cannot accomplish in refluxing toluene.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3 (Canada).
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Sayah
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ
keywords: PEPPSI; catalysis; cross-couple; sulfination