title: Lennert's lymphoma: clinicopathological profile of five cases.
abstract: OBJECTIVE
  Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS) rich in epithelioid histiocytes. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of Lennert's lymphoma from our country and determines the utility of T-cell receptor (TCR) gene rearrangement in the diagnosis.
  
  
  METHODS
  All cases diagnosed as Lennert's lymphoma during the period of January 2001 to August 2011 were included in this study. Hematoxylin and eosin (H and E) stained slides and immunohistochemistry results were analyzed and TCR gene rearrangement was performed.
  
  
  RESULTS
  There were five cases of Lennert's lymphoma diagnosed in our institution during this period, which included two males and three females. All cases showed effacement of lymph node architecture by diffuse infiltration of small lymphoid T cells [CD3+, CD4+, CD8+, T-cell intracellular antigen 1 (TIA-1+), Granzyme B-] and clusters of epithelioid histiocytes throughout the lymph node and scattered large transformed cells (CD20-, CD30+, CD15-/+). TCR rearrangement was done in three cases by polymerase chain reaction (PCR) and showed the presence of a clonal T-cell population.
  
  
  CONCLUSIONS
  Lennert's lymphoma constituted 0.11% of all non-Hodgkin lymphomas (NHLs) in our institution. Differentiation from classical Hodgkin's lymphoma is sometimes difficult by morphology and immunohistochemistry alone and TCR gene rearrangement was extremely useful in diagnosis.
authors.affiliation: Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sarda
authors.initials: S
authors.lastname: Parimal
authors.forename: Rekha
authors.initials: R
authors.lastname: Pai
authors.forename: Marie Therese
authors.initials: MT
authors.lastname: Manipadam
authors.forename: Sheila
authors.initials: S
authors.lastname: Nair
mesh_terms: D000328:Adult; D000368:Aged; D060965:Clonal Evolution; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement; D006644:Histiocytes / Q000166:cytology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000737:chemistry / Q000166:cytology
chemical_list: D011948:Receptors, Antigen, T-Cell