title: Laryngeal histoplasmosis: an occupational hazard.
abstract: Isolated laryngeal histoplasmosis is a very rare entity. It has variable clinical presentations that might mimic both benign and malignant lesions, and is usually associated with pulmonary and other disseminated forms of histoplasmosis. Herein, we report a case of primary laryngeal histoplasmosis without the involvement of other systems in a 70-year-old Chinese man, who previously worked as a miner. He presented with a history of hoarseness for two months, with no other associated symptoms. Direct laryngoscopy revealed irregularity of the posterior one-third of both vocal folds. Histopathological examination revealed the presence of Histoplasma capsulatumon periodic acidSchiff and Grocott's methenamine silver staining. The lesion resolved after one month of oral itraconazole treatment. However, the patient had to complete six months of antifungal treatment to prevent recurrence.
authors.affiliation: Department of Otolaryngology, Hospital Universiti Kebangsaan Malaysia, Jalan Yaakob Latiff, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia. tjwoei@yahoo.com.
authors.forename: Jian Woei
authors.initials: JW
authors.lastname: Teoh
authors.forename: Faridah
authors.initials: F
authors.lastname: Hassan
authors.forename: Mohd Razif
authors.initials: MR
authors.lastname: Mohamad Yunus
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007827:Laryngitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D007828:Laryngoscopy; D007830:Larynx / Q000382:microbiology* / Q000473:pathology; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B