title: [Comparative study on the diagnostic value of positron emission tomography and transcranial sonography in the diagnosis of Parkinson's disease].
abstract: OBJECTIVE
  To evaluate the consistency of dopamine transporter (DAT) positron emission tomography (PET) versus transcranial sonography (TCS) of Parkinson's disease (PD) patients.
  
  
  METHODS
  A total of 53 clinically diagnosed idopathic PD patients from Beijing Tiantan Hospital underwent (11)C-CFT PET and transcranial sonography (TCS). Asymmetric reduced dopaminergic function was a positive result of PET while unilateral hyperechoic area larger than 0.2 cm2 a positive result of TCS. Kappa test was used to evaluate the consistency of two methods.
  
  
  RESULTS
  Among them, 36 patients (67.92%) were TCS positive while 17 patients (32.08%) TCS negative. There were 48 patients (90.57%) with positive PET whereas PET was negative for 5 patients (9.43%). TCS and PET were both positive in 33 patients (62.26%) while 2 (3.77%) yielded a double negative result. As compared with the PET results, the sensitivity, specificity, positive predictive value and negative predictive value of TCS were 68.75%, 40%, 91.67% and 11.76% respectively. For Kappa test, Kappa = 0.042, P = 0.690, P > 0.05. It inferred a poor consistency.
  
  
  CONCLUSIONS
  TCS has a high predictive value for PET positive PD patients. For clinically diagnosed PD patients, a positive TCS result highly predicts PD without DAT-PET. However a negative TCS result can not rule out the possibility of PD. DAT-PET needs to be performed for further confirmation.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Qiao-hong
authors.initials: QH
authors.lastname: Ouyang
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D000368:Aged; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000378:metabolism; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D004298:Dopamine