title: Recurrent cerebral infarctions in a young patient: combined protein C and S deficiencies.
abstract: The possible etiologies of cerebral infarcts in young patients often present as diagnostic dilemmas as compared to older patients. Recently, deficiencies of fibrinolytic factors have emerged as an important etiology of stroke in the young population. Thrombophilic factors have been implicated in approximately 4 - 8% of the young strokes worldwide. Combined protein C and S deficiencies is a rare cause of recurrent ischaemic stroke in young population. Only a few sporadic cases have been reported in the literature. We are reporting a case of combined protein C and S deficiency-related recurrent ischaemic stroke in an 18 years old girl. Early diagnosis and targeted therapeutic management can help such patients to prevent recurrent thrombotic episodes.
authors.affiliation: Department of Obstetrics and Gynaecology, Nishtar Medical College and Hospital, Multan.
authors.forename: Ammara
authors.initials: A
authors.lastname: Sultan
authors.forename: Ijaz Hussain
authors.initials: IH
authors.lastname: Malik
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000008:administration & dosage; D002544:Cerebral Infarction / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D011486:Protein C / Q000378:metabolism; D020151:Protein C Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D017293:Protein S / Q000378:metabolism; D018455:Protein S Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D011486:Protein C; D017293:Protein S; D006493:Heparin