title: Isosakuranetin-5-O-rutinoside: a new flavanone with antidepressant activity isolated from Salvia elegans Vahl.
abstract: Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
authors.affiliation: Southern Biomedical Research Center, Mexican Institute of Social Security, Argentina 1, Centro 62790, Xochitepec, Morelos, Mexico. jtortora2@yahoo.es.
authors.forename: Manáses
authors.initials: M
authors.lastname: González-Cortazar
authors.forename: Ana María
authors.initials: AM
authors.lastname: Maldonado-Abarca
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez-Ferrer
authors.forename: Silvia
authors.initials: S
authors.lastname: Marquina
authors.forename: Elsa
authors.initials: E
authors.lastname: Ventura-Zapata
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamilpa
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000627:therapeutic use*; D044950:Flavanones / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D027544:Salvia / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D044950:Flavanones; D005419:Flavonoids; C538973:isosakuranetin; C028610:flavanone