title: The signaling pathway of NADPH oxidase and its role in glomerular diseases.
abstract: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox), a major source of reactive oxygen species, is a critical mediator of redox signaling. It is well-documented that oxidative stress is associated with the development of glomerular diseases (GN). Hence, the Nox was also thought to be involved in the pathogenesis of GN. However, the expression of Nox in various GN was not consistent, the mechanisms by which the activity of the Nox enzymes in regulating renal cells remains unclear. Signaling pathways might be very important in the pathogenesis of GN. We performed this review to provide a relatively complete signaling pathways flowchart for Nox to the investigators who were interested in the role of Nox in the pathogenesis of GN. Here, we reviewed the signal transduction pathway of Nox and its role in the pathogenesis of GN.
authors.affiliation: Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University , Nanjing , People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Mao
authors.forename: Songming
authors.initials: S
authors.lastname: Huang
mesh_terms: D006801:Humans; D019255:NADPH Oxidases / Q000235:genetics* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics*; D060066:Protein Interaction Maps; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D019255:NADPH Oxidases