title: Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures.
abstract: Two types of fibers were prepared by using bio-based materials: a mono-filament made from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a multi-filament made from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polylactic acid (PLA) blend. The two fibers were evaluated for mechanical properties, biocompatibility and degradability for the potential application as medical sutures. The PHBHHx fiber showed remarkable biocompatibility by H.E. Stainning, with very little impact to the surrounding tissues. The degradation of the fiber was observed by SEM after implantation for 36 weeks, and the major degradation product was detected after 96 weeks. Consistently, the PHBHHx fiber maintained more than half of the mechanical properties after 96 weeks. The other fiber was prepared by twisting PHBV/PLA blend strands to a bunch, and showed high biocompatibility and relatively high degradability. The bunched structure loosed after 36 weeks of implantation. These low-cost and easily prepared fibers have great potential in medical applications, since they could avoid the formation of fibrous capsule, reduce the size of scar, and degrade into non-toxic and even beneficial products.
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: He
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Hu
authors.forename: Mengda
authors.initials: M
authors.lastname: Ren
authors.forename: Changkun
authors.initials: C
authors.lastname: Ding
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Qun
authors.initials: Q
authors.lastname: Gu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D001672:Biocompatible Materials; D002208:Caproates; D002850:Chromatography, Gel; D019344:Lactic Acid; D008297:Male; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers; D051381:Rats; D017207:Rats, Sprague-Dawley; D013537:Sutures; D013718:Tensile Strength; D000094122:Polyhydroxybutyrates
chemical_list: D020155:3-Hydroxybutyric Acid; D001672:Biocompatible Materials; D002208:Caproates; D019344:Lactic Acid; D011091:Polyesters; D011108:Polymers; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates; C115940:poly(3-hydroxybutyrate-co-3-hydroxyhexanoate); C033616:poly(lactide)