title: Comparison of the haemodynamic effects of pyrethroid insecticide and amodiaquine in rats.
abstract: Malaria infection is a common cause of morbidity and mortality especially in the tropics and subtropics. This has led to the increased prophylactic use ofpyrethroid insecticides and/or Amodiaquine (Aq) to combat the parasitic protozoan infection. The aim of this study was to investigate the comparative haemodynamic effects of pyrethroid insecticide and amodiaquine in rats. Experimental rats were randomly allocated into seven groups of five rats in each. Groups 1, 2 and 3 were exposed to pyrethroid by inhalation for 1, 2 and 3 min, respectively, while groups 4, 5 and 6 were administered Aqper oral at 5, 10 and 15 mg kg(-1) b.wt., respectively. Control rats were neither exposed to pyrethroid nor administered Aq. Pyrethroid insecticide led to reduced systolic, diastolic and mean arterial pressures, but increased pulse pressure. Aq treatment did not cause any significant variation in haemodynamic variables. Heart rate was comparable in all groups. Results from the study provide extended safety/toxicity profile for pyrethroid use and Aq treatment. Aq showed no cardiotoxic potential, while pyrethroids have hypotensive effect. It is thus recommended that exposure to pyrethroids should be minimized.
authors.affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
authors.forename: W A
authors.initials: WA
authors.lastname: Saka
authors.forename: R E
authors.initials: RE
authors.lastname: Akhigbe
authors.forename: O S
authors.initials: OS
authors.lastname: Oyekunle
authors.forename: O O
authors.initials: OO
authors.lastname: Adedipe
authors.forename: O A
authors.initials: OA
authors.lastname: Akinwande
mesh_terms: D000655:Amodiaquine / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000633:toxicity; D062186:Arterial Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology; D007306:Insecticides / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D011722:Pyrethrins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment
chemical_list: D000962:Antimalarials; D007306:Insecticides; D011722:Pyrethrins; D000655:Amodiaquine