title: Folate-conjugated albumin nanoparticles for rheumatoid arthritis-targeted delivery of etoricoxib.
abstract: OBJECTIVE
  The present study discusses folic acid-etoricoxib-bovine serum albumin nanoparticles (F-ETX-NPs) using folic acid as an over expressed folate receptor ligand for activated macrophages in targeting of rheumatoid arthritis.
  
  
  METHODS
  For this purpose etoricoxib-loaded BSA nanoparticles (ETX-NPs) were prepared by desolvation method and activated folic acid conjugation with free amine group of BSA was confirmed by FTIR study and zeta potential measurements.
  
  
  RESULTS
  The F-ETX-NPs showed spherical in shape with 215.8 ± 3.2 nm average size + 7.8 mV zeta potential, 72 ± 1.3% etoricoxib entrapment efficiency and showed 93.1 ± 2.2% cumulative etoricoxib release upto 72 h. The etoricoxib concentration from F-ETX-NPs was found to be 9.67 ± 0.34 µg/g in inflamed joint after 24 h administration revealed remarkably targeting potential to the activated macrophages cells and keep at a high level during the experiment.
  
  
  CONCLUSIONS
  These results suggest that F-ETX-NPs are potentially vector for activated macrophages cells targeting of rheumatoid arthritis.
authors.affiliation: Pharmaceutics Devision, ADINA Institute of Pharmaceutical Sciences , Sagar, Madhya Pradesh , India.
authors.forename: Upasana
authors.initials: U
authors.lastname: Bilthariya
authors.forename: Nivrati
authors.initials: N
authors.lastname: Jain
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Rajoriya
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Jain
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D002417:Cattle; D016503:Drug Delivery Systems / Q000379:methods*; D000077613:Etoricoxib; D005492:Folic Acid / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D011725:Pyridines / Q000008:administration & dosage* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage* / Q000737:chemistry; D013450:Sulfones / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D011725:Pyridines; D013450:Sulfones; D012710:Serum Albumin, Bovine; D005492:Folic Acid; D000077613:Etoricoxib
keywords: Activated macrophages targeting; etoricoxib; folate conjugation; inflammation screening; rheumatoid arthritis