title: Endovascular treatment of intracranial atherosclerotic disease.
abstract: Stroke is the third leading cause of death in the United States. Intracranial atherosclerotic disease plays a role in cerebrovascular accidents, with well-characterized modifiable and nonmodifiable risk factors. Surgical bypass has so far not proved to be superior to medical therapy. Both medical and endovascular therapies for intracranial atherosclerosis have evolved since the initial off-label use of cardiac devices for its treatment. Initial reports on the results of stent placement for symptomatic high-grade intracranial atherosclerotic disease were initially encouraging. However, debate remains as to the optimal treatment of symptomatic intracranial atherosclerotic disease.
authors.affiliation: Stroke and Cerebrovascular Center of New Jersey, 750 Brunswick Avenue, Trenton, NJ 08638, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lenart
authors.forename: Mandy J
authors.initials: MJ
authors.lastname: Binning
authors.forename: Erol
authors.initials: E
authors.lastname: Veznedaroglu
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000175:diagnosis / Q000628:therapy*; D002548:Cerebral Revascularization / Q000295:instrumentation / Q000379:methods*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D059906:Neuroimaging / Q000379:methods; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015607:Stents; D025321:Surgery, Computer-Assisted / Q000379:methods
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors
keywords: Atherosclerosis; Endovascular treatment; Ischemic stroke; Risk factors