title: The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study.
abstract: Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measure of arterial stiffness obtained using an automated system. Although baPWVs have been widely used as a non-invasive marker for evaluation of arterial stiffness, evidence for the prognostic value of baPWV in the general population is scarce. In this study, we assessed the association between baPWV and future cardiovascular disease (CVD) incidence in a Japanese population. From 2002 to 2009, baPWV was measured in a total of 4164 men and women without a history of CVD, and they were followed up until the end of 2009 with a median follow-up period of 6.5 years. Hazard ratios (HRs) for CVD incidence according to baPWV levels were calculated using a Cox proportional hazards model adjusted for potential confounding factors, including seated or supine blood pressure (BP). During the follow-up period, we observed 40 incident cases of CVD. In multivariable-adjusted model, baPWV as a continuous variable was not significantly associated with future CVD risk after adjustment for supine BP. However, compared with lower baPWV category (<18 m s(-1)), higher baPWV (< or = 18.0 m s(-1)) was significantly associated with an increased CVD risk (HR: 2.70, 95% confidence interval: 1.18-6.19). Higher baPWV (< or = 18.0 m s(-1)) would be an independent predictor of future CVD event in the general Japanese population.
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takashima
authors.affiliation: 1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: T C
authors.initials: TC
authors.lastname: Turin
authors.affiliation: 1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Office for Research Ethics & Bioethics, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsui
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Rumana
authors.affiliation: 1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: 1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Course for Nurse Teachers, Osaka Kyoiku University, Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kadota
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Takashima City Hospital, Shiga, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
authors.affiliation: Makino Hospital, Shiga, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.affiliation: Takashima City Hospital, Shiga, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
authors.affiliation: Otsu Red Cross Hospital, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.affiliation: Shiga Medical Center for Adults, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawakani
authors.affiliation: Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hamajima
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.affiliation: 1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan.
authors.forename: H
authors.identifier: 0000000277424253
authors.initials: H
authors.lastname: Ueshima
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kita
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D044466:Asian People / Q000706:statistics & numerical data*; D001783:Blood Flow Velocity / Q000502:physiology*; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000503:physiopathology*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011673:Pulsatile Flow / Q000502:physiology*; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology / Q000503:physiopathology; D059289:Vascular Stiffness / Q000502:physiology