title: Microperimetry of subretinal drusenoid deposits.
abstract: OBJECTIVE
  To investigate light sensitivity in eyes presenting with subretinal drusenoid deposits (SDD).
  
  
  METHODS
  All consecutive patients with SDD only seen between January 2012 and July 2012 were included. A control group of consecutive age- and sex-matched control subjects presenting at least one eye with early age-related macular degeneration was considered. In all cases best-corrected visual acuity (BCVA), color fundus photography, fundus autofluorescence imaging and spectral-domain-optical coherence tomography with integrated microperimetry were performed.
  
  
  RESULTS
  Twenty-one eyes (21 patients, 9 females, 12 males, mean age 69.2 ± 5.3 years, mean BCVA 0.18 ± 0.14 LogMAR) were included in the SDD group. Twenty eyes of 20 patients (13 females, 7 males, mean age 69.1 ± 3.9 years, mean BCVA 0.16 ± 0.15 LogMAR) were included in the control group. In eyes with SDD the choroid was thinner at the subfoveal location, and at 1,500 μm superior, inferior, temporal and nasal to the fovea (p < 0.05). In eyes with SDD, the overall mean light sensitivity in the central macula (4.21 ± 2.46 dB) was significantly reduced when compared to the control group (6.81 ± 2.12 dB, p = 0.001), while stable fixation was present in both groups. Correlation between BCVA and mean light sensitivity in the central 7 × 7 mm square was low in the SDD group (Pearson's rho = 0.4, p = 0.01), while it was good in the control group (Pearson's rho = 0.7, p = 0.001).
  
  
  CONCLUSIONS
  Eyes with SDD showed reduced sensitivity despite preserved BCVA. Reduced choroidal thickness could be involved in reduction of light sensitivity.
authors.affiliation: Eye Department, University Federico II, Naples, Italy.
authors.forename: Raimondo
authors.initials: R
authors.lastname: Forte
authors.forename: Gilda
authors.initials: G
authors.lastname: Cennamo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: de Crecchio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cennamo
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D015593:Retinal Drusen / Q000503:physiopathology*; D012307:Risk Factors; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields / Q000502:physiology*