title: Growth and obesity and its association with plasma level of steroid hormones and insulin-like growth factor-I (IGF-I) in Slovak female students.
abstract: The aim of the present study was to examine the possible role of steroid hormones and insulin-like growth factor 1 (IGF-I) in the control of human growth and obesity. We measured plasma level of progesterone, testosterone, estradiol and IGF-I in 301 young women at different stages of their ovarian cycle, and compared them to the standard morphometric indexes of their growth and obesity - body height, body weight, abdomen circumstance and waist to hip ratio (WHR). The ovarian cycle-dependent changes in plasma progesterone and estradiol, but not in testosterone and IGF-I level were found. Young women with higher body height had significantly higher plasma level of estradiol, testosterone and IGF-I, but not of progesterone, compared to subjects with lower body height in both follicular and luteal phases of the ovarian cycle. Subjects with a higher body weight had significantly higher plasma estradiol and progesterone, but not testosterone and IGF-I than subjects with lower body weight in both follicular and luteal phases of ovarian cycle. Women with a higher abdomen circumference had significantly lower plasma estradiol, but not the other hormones than the subjects with lower abdomen circumference. Women with higher WHR index had significantly higher plasma level of estradiol, but not other hormones than subjects with lower WHR index in both follicular and luteal phases of ovarian cycle. The present observations suggests: (1) that luteal phase of the women ovarian cycle is characterised by a dramatically increase in both progesterone and estradiol, but not in testosterone and IGF-I release, (2) that in human females growth can be up-regulated by testosterone, estradiol and IGF-I, but not by progesterone, (3) that body mass can be up-regulated by progesterone and estradiol, but not by testosterone or IGF-I, and (4) that women obesity (high WHR, but not abdomen circumference) can be promoted by estradiol, but not by other steroid hormones or IGF-I (Tab. 1, Fig. 4, Ref. 45).
authors.forename: T
authors.initials: T
authors.lastname: Zatko
authors.forename: B
authors.initials: B
authors.lastname: Matejovicova
authors.forename: M
authors.initials: M
authors.lastname: Boledovicova
authors.forename: M
authors.initials: M
authors.lastname: Vondrakova
authors.forename: A
authors.initials: A
authors.lastname: Bezakova
authors.forename: A V
authors.initials: AV
authors.lastname: Sirotkin
mesh_terms: D004958:Estradiol / Q000097:blood*; D005260:Female; D006128:Growth; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D009765:Obesity / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D018154:Slovakia; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I
keywords: growth, obesity, estradiol, testosterone, progesterone, IGF-I.