title: Distribution of extended spectrum beta-lactamase resistance genes among nosocomial imipenem resistant A. Baumannii strains harboring BLAoxa-23 carbapenemases isolated from Ilam and Tehran.
abstract: Antimicrobial susceptibility and ESBLs genes of 42 imipenem resistant A. baumannii carried out by DDST and PCR. The most antimicrobial agents against A. baumannii strains, harboring blaOXA-23-like carbapenemases, were meropenem (33.4 percent), piperacillin-tazobactam (23.9 percent), ceftazidime (14.3 percent) and gatifoxacin (19.1 percent), respectively. All the 42 isolates harbored the blaTEM gene, but the bla SHV and VEB genes were not present among all the isolates. With the exception of seven isolates, all the A. baumannii strains harbor blaTEM showed ESBL positivity in DDST. The result of this study show that resistance against antimicrobial agents, especially carbapenems, has increased and that blaTEM harboring A. baumannii strains can be help the blaOXA-like carbapenemase genes to code for resistance against carbapenem antibiotics.
authors.affiliation: Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University of Putra Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Taherikalani
authors.forename: Z
authors.initials: Z
authors.lastname: Sekawi
authors.forename: F
authors.initials: F
authors.lastname: Azizi-Jalilian
authors.forename: B
authors.initials: B
authors.lastname: Keshavarz
authors.forename: S
authors.initials: S
authors.lastname: Soroush
authors.forename: M
authors.initials: M
authors.lastname: Akbari
authors.forename: M
authors.initials: M
authors.lastname: Emaneini
authors.forename: P
authors.initials: P
authors.lastname: Asadollahi
authors.forename: M H
authors.initials: MH
authors.lastname: Maleki
authors.forename: S
authors.initials: S
authors.lastname: Mohammadi
authors.forename: I
authors.initials: I
authors.lastname: Pakzad
authors.forename: A
authors.initials: A
authors.lastname: Delpisheh
authors.forename: K
authors.initials: K
authors.lastname: Asadollahi
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases