title: ADAMTS proteoglycanases in the physiological and pathological central nervous system.
abstract: ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
authors.affiliation: Department of Neurobiology, A, I, Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P,O, Box 1627, 70211 Kuopio, Finland. sighild.lemarchant@uef.fi.
authors.forename: Sighild
authors.initials: S
authors.lastname: Lemarchant
authors.forename: Mathilde
authors.initials: M
authors.lastname: Pruvost
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
authors.forename: Evelyne
authors.initials: E
authors.lastname: Emery
authors.forename: Denis
authors.initials: D
authors.lastname: Vivien
authors.forename: Katja
authors.initials: K
authors.lastname: Kanninen
authors.forename: Jari
authors.initials: J
authors.lastname: Koistinaho
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000071097:ADAMTS1 Protein; D000071121:ADAMTS4 Protein; D000071116:ADAMTS5 Protein; D000071119:ADAMTS9 Protein; D000818:Animals; D002490:Central Nervous System / Q000201:enzymology*; D006801:Humans; D011348:Procollagen N-Endopeptidase / Q000378:metabolism*
chemical_list: D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human; D000071119:ADAMTS9 Protein; C412869:ADAMTS9 protein, human; D011348:Procollagen N-Endopeptidase; D000071121:ADAMTS4 Protein