title: Study of the resolution of amino acids and aminoalcohols in organic solvents.
abstract: The enzymatic resolution of racemic phenylglycine, phenylglycinol and phenylalaninol has been studied in organic solvents under a variety of experimental conditions. Subtilisin in 3-methyl-3-pentanol was effective for the resolution of phenylglycine esters, via N-acylation with trifluoroethyl butyrate. Porcine pancreatic lipase in ethyl acetate gave satisfactory results in the resolution of phenylglycinol and phenylalaninol; theα orβ position of the phenyl group was found to influence both the rate and the chemioselectivity of the reaction.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Universita' di Milano, via Venezian 21, I-20133, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Orsini
authors.forename: F
authors.initials: F
authors.lastname: Pelizzoni
authors.forename: C
authors.initials: C
authors.lastname: Ghioni