title: Gender-specific pleiotropic bone-muscle relationship in the elderly from a nationwide survey (KNHANES IV).
abstract: CONCLUSIONS
  The aim of this study was to examine the gender-specific association between sarcopenia and bone geometry/metabolic parameters. Low muscle mass was associated with greater deterioration of bone than in deterioration of glucose or lipid profiles. This bone-muscle relationship was more prominent in men than in women.
  
  
  BACKGROUND
  There are few studies that report on gender differences in the effects of low muscle mass on bone and metabolic parameters in elderly subjects. This study aimed to assess the gender-specific influence of muscle mass on bone and metabolic parameters.
  
  
  METHODS
  A total of 2,264 participants (940 men and 1,324 women) whose age ranged from 65 to 92 years were analyzed using data from The Fourth Korea National Health and Nutrition Examination Surveys (2008-2009). We measured bone mineral density (BMD) and appendicular muscle mass using the dual-energy X-ray absorptiometry and also measured metabolic profiles.
  
  
  RESULTS
  The age-related trend in bone and muscle coincided in men but not in women. Femoral neck (FN) and total hip (TH) BMD were highly correlated with muscle mass in both genders. However, in women, this correlation was not significant in the lumbar spine (LS). In addition, this positive correlation was stronger in the FN or TH than in the LS and was stronger in men than in women. Subjects with sarcopenia were at a higher risk for osteoporosis in the FN, TH, and LS in men, and in the TH and FN in women. The degree of association between muscle mass and metabolic profiles was relatively very weak.
  
  
  CONCLUSIONS
  Bone-muscle relationship was more prominent in men than in women. The gender differences in bone-muscle relationship may be helpful for the development of gender-specific preventive strategies in the elderly, especially in men.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Huh
authors.forename: M K
authors.initials: MK
authors.lastname: Song
authors.forename: K H
authors.initials: KH
authors.lastname: Park
authors.forename: K J
authors.initials: KJ
authors.lastname: Kim
authors.forename: J E
authors.initials: JE
authors.lastname: Kim
authors.forename: Y M
authors.initials: YM
authors.lastname: Rhee
authors.forename: S-K
authors.initials: SK
authors.lastname: Lim
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000886:Anthropometry / Q000379:methods; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D009749:Nutrition Surveys; D009929:Organ Size / Q000502:physiology; D010024:Osteoporosis / Q000453:epidemiology / Q000503:physiopathology*; D056910:Republic of Korea / Q000453:epidemiology; D055948:Sarcopenia / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D012727:Sex Characteristics; D055815:Young Adult