title: Management of gastric cancer in Asia: resource-stratified guidelines.
abstract: Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.forename: Yan-Shen
authors.initials: YS
authors.lastname: Shan
authors.forename: Huang-Ming
authors.initials: HM
authors.lastname: Hu
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Price
authors.forename: Bhawna
authors.initials: B
authors.lastname: Sirohi
authors.forename: Kun-Huei
authors.initials: KH
authors.lastname: Yeh
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Yang
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sano
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Zhang
authors.forename: Sook Ryun
authors.initials: SR
authors.lastname: Park
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujii
authors.forename: Yoon-Koo
authors.initials: YK
authors.lastname: Kang
authors.forename: Li-Tzong
authors.initials: LT
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001208:Asia / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant / Q000592:standards; D003695:Delivery of Health Care / Q000592:standards; D055088:Early Detection of Cancer; D005743:Gastrectomy / Q000592:standards; D005773:Gastroscopy / Q000592:standards; D006295:Health Resources / Q000191:economics / Q000592:standards*; D006297:Health Services Accessibility / Q000592:standards; D054625:Healthcare Disparities / Q000592:standards; D006801:Humans; D008495:Medical Oncology / Q000191:economics / Q000592:standards*; D058990:Molecular Targeted Therapy / Q000592:standards; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents