title: Aggressive plasmablastic multiple myeloma in a 42-year-old: is inflammatory bowel disease or infliximab treatment to be blamed?
abstract: A man in his early 40s with a history of ulcerative colitis, treated with infliximab, was diagnosed with plasmablastic multiple myeloma. He was treated with chemotherapy and stem cell transplant but developed recurrence and ultimately died from metastatic disease. Could inflammatory bowel disease or infliximab therapy have any role in development of myeloma in this young patient? The role of inflammatory bowel disease and infliximab therapy in the development of multiple myeloma is controversial but interesting and worth considering.
authors.affiliation: Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Yadav
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Ishmael A
authors.initials: IA
authors.lastname: Jaiyesimi
authors.forename: Mohammad Muhsin
authors.initials: MM
authors.lastname: Chisti
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D000069285:Infliximab; D008297:Male; D009101:Multiple Myeloma / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000069285:Infliximab