title: Gonococcal endocarditis: a case report and review of the literature.
abstract: A 59-year-old Caucasian male presented with progressive dyspnea, arthralgias and fever for three days. A diastolic regurgitation murmur was detected in the aortic area. A transesophageal echocardiograph showed several vegetations and severe aortic regurgitation. Blood cultures yielded Neisseria gonorrhoeae beta-lactamase negative. The patient had not noticed any urogenital discomfort or urethral discharge. The patient successfully underwent surgery for septal abscess debridement. The patient received ceftriaxone 2 g bid for eight weeks and the clinical follow-up was uneventful. The review of the literature revealed a total of the 38 additional cases reported between 1980 and the present. The majority of the patients were young, male and with native valve involvement. There has been a clear tendency for left-sided valve involvement (especially in the aortic valve). All valve cultures were reported negative despite, in most cases, the marked tissue destruction. Polymerase chain reaction was performed in two patients and positive results were shown in both. Cultures of exudates from other locations were negative in most cases. One striking fact is the high proportion of patients who underwent surgery (72 %). Information regarding antibiotic sensitivity was available in 28 cases, with penicillin resistance reported in six patients (21 %) and intermediate sensitivity in four patients (14 %). Resistance to ciprofloxacin was reported in two cases (7 %). A rapid increase and distribution of isolates resistant to third generation cephalosporins have been recently detected. The mortality is high, particularly taking into account that most were young patients who had not presented previous heart disease.
authors.affiliation: Department of Internal Medicine (Infectious Diseases Unit), Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Maestro Rodrigo 2, Majadahonda, 28220, Madrid, Spain, aramos220@gmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ramos
authors.forename: Pablo
authors.initials: P
authors.lastname: García-Pavía
authors.forename: Beatriz
authors.initials: B
authors.lastname: Orden
authors.forename: Marta
authors.initials: M
authors.lastname: Cobo
authors.forename: Margarita
authors.initials: M
authors.lastname: Sánchez-Castilla
authors.forename: Isabel
authors.initials: I
authors.lastname: Sánchez-Romero
authors.forename: Elena
authors.initials: E
authors.lastname: Múñez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Marín
authors.forename: Carlos
authors.initials: C
authors.lastname: García-Montero
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D006069:Gonorrhea / Q000150:complications* / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents