title: A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants.
abstract: Acute kidney injury (AKI) is the common clinical syndrome which is associated with increased morbidity and mortality. The severity extends from less to more advanced spectrums which link to biological, physical and chemical agents. Oxidative stress (OS)-related AKI has demonstrated the increasing of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the decreasing of endogenous antioxidants. Medicinal plants-derived antioxidants can be ameliorated oxidative stress-related AKI through reduction of lipid peroxidation (LPO) and enhancement of activities and levels of endogenous antioxidants. Therefore, medicinal plants are good sources of exogenous antioxidants which might be considered the important remedies to ameliorate pathological alterations in oxidative stress-related AKI.
authors.affiliation: School of Medicine, Walailak University, Nakhon Si Thammarat, 80161, Thailand.
authors.forename: Sarawoot
authors.initials: S
authors.lastname: Palipoch
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D000975:Antioxidants; D010936:Plant Extracts
keywords: Acute kidney injury; Medicinal plant; Oxidative stress