title: Preoperative cardiac variables of diastolic dysfunction and clinical outcomes in lung transplant recipients.
abstract: Background. Orthotopic lung transplantation is now widely performed in patients with advanced lung disease. Patients with moderate or severe ventricular systolic dysfunction are typically excluded from lung transplantation; however, there is a paucity of data regarding the prognostic significance of abnormal left ventricular diastolic function and elevated pretransplant pulmonary pressures. Methods. We reviewed the characteristics of 111 patients who underwent bilateral and unilateral lung transplants from 200 to 2009 in order to evaluate the prognostic significance of preoperative markers of diastolic function, including invasively measured pulmonary capillary wedge pressure (PCWP) and echocardiographic variables of diastolic dysfunction including mitral A > E and A' > E'. Results. Out of 111 patients, 62 were male (56%) and average age was 54.0 ± 10.5 years. Traditional echocardiographic Doppler variables of abnormal diastolic function, including A' > E' and A > E, did not predict adverse events (P = 0.49). Mildly elevated pretransplant PCWP (16-20 mmHg) and moderately/severely elevated PCWP (>20 mmHg) were not associated with adverse clinical events after transplant (P = 0.30). Additionally, all clinical endpoints did not show any statistical significance between the two groups. Conclusions. Pre-lung transplant invasive and echocardiographic findings of elevated pulmonary pressures and abnormal left ventricular diastolic function are not predictive of adverse posttransplant clinical events.
authors.affiliation: Department of Cardiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Yadlapati
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Lynch
authors.forename: Rajan
authors.initials: R
authors.lastname: Saggar
authors.forename: David
authors.initials: D
authors.lastname: Ross
authors.forename: John A
authors.initials: JA
authors.lastname: Belperio
authors.forename: Stephen
authors.initials: S
authors.lastname: Weigt
authors.forename: Abbas
authors.initials: A
authors.lastname: Ardehali
authors.forename: Tristan
authors.initials: T
authors.lastname: Grogan
authors.forename: Eric H
authors.initials: EH
authors.lastname: Yang
authors.forename: Jamil
authors.initials: J
authors.lastname: Aboulhosn