title: HDAC inhibitors and their potential applications to glioblastoma therapy.
abstract: Natural killer (NK) cells are integral components of the antitumor immune response. The downregulation of ligands for NK-cell stimulatory receptors represents a strategy whereby glioblastoma cells can evade NK-cell attacks. Histone deacetylase inhibitors can stimulate the (re)expression of these ligands, driving cytotoxic responses against glioblastoma cells that efficiently inhibit tumor growth.
authors.affiliation: Laboratory of Immunology; Department of Vascular Neurology; Hertie Institute for Clinical Brain Research; University of Tuebingen; Tuebingen, Germany.
authors.forename: Eleni
authors.initials: E
authors.lastname: Adamopoulou
authors.forename: Ulrike
authors.initials: U
authors.lastname: Naumann
keywords: HDAC inhibition; NK cells; glioblastoma; immunomodulation