title: Aptamers as theranostic agents: modifications, serum stability and functionalisation.
abstract: Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
authors.affiliation: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia. sarah.shigdar@deakin.edu.au.
authors.forename: Sarah
authors.initials: S
authors.lastname: Shigdar
authors.forename: Joanna
authors.initials: J
authors.lastname: Macdonald
authors.forename: Michael
authors.initials: M
authors.lastname: O'Connor
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Dongxi
authors.initials: D
authors.lastname: Xiang
authors.forename: Hadi
authors.initials: H
authors.lastname: Al Shamaileh
authors.forename: Liang
authors.initials: L
authors.lastname: Qiao
authors.forename: Ming
authors.initials: M
authors.lastname: Wei
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Lingxue
authors.initials: L
authors.lastname: Kong
authors.forename: Santanu
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: ChunGuang
authors.initials: C
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000627:therapeutic use*; D052158:Aptamers, Peptide / Q000627:therapeutic use*; D015374:Biosensing Techniques / Q000379:methods*; D006801:Humans; D052156:SELEX Aptamer Technique / Q000295:instrumentation* / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide; D052158:Aptamers, Peptide