title: The nexus of chromatin regulation and intermediary metabolism.
abstract: Living organisms and individual cells continuously adapt to changes in their environment. Those changes are particularly sensitive to fluctuations in the availability of energy substrates. The cellular transcriptional machinery and its chromatin-associated proteins integrate environmental inputs to mediate homeostatic responses through gene regulation. Numerous connections between products of intermediary metabolism and chromatin proteins have recently been identified. Chromatin modifications that occur in response to metabolic signals are dynamic or stable and might even be inherited transgenerationally. These emerging concepts have biological relevance to tissue homeostasis, disease and ageing.
authors.affiliation: Gladstone Institutes, University of California, San Francisco, California 94941, USA.
authors.forename: Philipp
authors.initials: P
authors.lastname: Gut
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008660:Metabolism; D039904:Pluripotent Stem Cells / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D037761:Sirtuins; D006655:Histone Deacetylases