title: Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation.
abstract: Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFβ1 blockade and the production of interleukin-12.
authors.affiliation: Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan ; Institute of Clinical Medicine and Research; The Jikei University School of Medicine; Tokyo, Japan ; Department of Oncology; Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Koido
authors.forename: Sadamu
authors.initials: S
authors.lastname: Homma
authors.forename: Masato
authors.initials: M
authors.lastname: Okamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Namiki
authors.forename: Shin
authors.initials: S
authors.lastname: Kan
authors.forename: Kazuki
authors.initials: K
authors.lastname: Takakura
authors.forename: Mikio
authors.initials: M
authors.lastname: Kajihara
authors.forename: Kan
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Eiich
authors.initials: E
authors.lastname: Hara
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ohkusa
authors.forename: Jianlin
authors.initials: J
authors.lastname: Gong
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
keywords: DC/tumor cell fusion vaccine; Toll-like receptor; cytotoxic T lymphocyte; dendritic cell; immunologic tumor cell death