title: Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus.
abstract: A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, P.R. China, Pharmacognosy Department, Faculty of Pharmacy, Assiut University , Assiut, Egypt, Laboratory of Molecular Vector Biology, Haidian Center for Disease Prevention and Control , Haidian District, Beijing, 100094, P.R. China, Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen , Old Aberdeen, AB24 3UE, Scotland, U.K., and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, 100050, P.R. China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Chen
authors.forename: Xueting
authors.initials: X
authors.lastname: Liu
authors.forename: Wael M
authors.initials: WM
authors.lastname: Abdel-Mageed
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Hou
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Xie
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D011083:Polycyclic Compounds; C587706:nivetetracyclate A; C587707:nivetetracyclate B