title: A highly efficient and enantioselective intramolecular Cannizzaro reaction under TOX/Cu(II) catalysis.
abstract: An asymmetric intramolecular Cannizzaro reaction of aryl and alkyl glyoxals with alcohols has been realized with an unprecedented high level of enantioselectivity, on the basis of a newly developed congested TOX ligand and a gradual liberation protocol of active glyoxals from glyoxal monohydrates. Preliminary results suggested a mechanism of enantioselective addition of alcohols to glyoxals contributing most to the stereoselectivity, other than by the dynamic kinetic resolution of hemiacetal intermediates.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, P.R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wang
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Tao
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Sun
authors.forename: Saihu
authors.initials: S
authors.lastname: Liao
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang