title: A comparative study of anti-gastric cancer activity between aqueous extract and ethanol extract of Folium Cordylines Fruticosae.
abstract: The active components in Folium Cordylines Fruticosae were extracted by heat reflux method. The solvents used were distilled water and ethanol. The effects of two types of extracts on gastric cancer cells were compared; dry extract yields were calculated, as well as the inhibition rates of gastric cancer MGC-803 cell proliferation and the colony cell counts. The micro-Kjeldahl method was used to measure the cell protein contents and to make a comprehensive comparison. The results showed that the MGC-803 cell inhibition rates of three different concentrations (32.5, 75 and 150 mg/ml) of ethanol extracts increased with the increase of concentration, which was 48.9% at a concentration of 150 mg/ml; aqueous extract of Folium Cordylines Fruticosae had very low inhibitory activity at a low concentration (32.5 mg/ml), which was remained at about 20%. After being affected by two types of extracts, cells had uneven sizes, with very low brightness, while the normal cells presented a uniform full form, with high definition.
authors.affiliation: Department of Digestion Medicine, The Third Affiliated Hospital of Xiang Ya School of Medicine, Central South University, Changsha 410078, Hunan, People's Republic of China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Liu
authors.forename: Dongbo
authors.initials: D
authors.lastname: Cao
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Xiao
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Lian
authors.initials: L
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Shourong
authors.initials: S
authors.lastname: Shen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D031406:Cordyline; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D000431:Ethanol; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D012997:Solvents; D013274:Stomach Neoplasms / Q000188:drug therapy*; D014867:Water
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol
keywords: Anti-gastric Cancer MGC-803 cell; Folium Cordylines Fruticosae