title: Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: evidence from 1410 subjects.
abstract: OBJECTIVE
  Whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene increases susceptibility to allergic rhinitis (AR) is still undetermined. Therefore, this meta-analysis was performed to systematically assess the possible association between them.
  
  
  METHODS
  The OVID, Medline, Embase, Web of Science, CNKI and Wangfang databases were searched to identify the eligible studies focusing on the association between ACE I/D polymorphism and susceptibility to AR.
  
  
  RESULTS
  A total of 1410 subjects from six studies were subjected to meta-analysis. In the overall analysis, ACE I/D polymorphism had a statistically significant association with increased AR risk under all genetic models (p<0.05). In the subgroup analysis by ethnicity, significant elevated AR risks were associated with ACE I/D polymorphism in Asians under all genetic models (p<0.05) and in Caucasians under under allele contrast, homozygous comparison and recessive models (p<0.05). In the subgroup analysis by age, ACE I/D polymorphism was associated with significant elevated risks of AR in adults (p<0.05) but not in children (p>0.05) under all genetic models.
  
  
  CONCLUSIONS
  The ACE I/D polymorphism may be a risk factor for AR and studies with large sample size and representative population are warranted to verify this finding.
authors.affiliation: Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Biology and Chemical Engineering, Fuqing Branch of Fujian Normal University, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, China 96zheng@gmail.com.
authors.forename: Chun-Quan
authors.initials: CQ
authors.lastname: Zheng
mesh_terms: D017677:Age Distribution; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D065631:Rhinitis, Allergic / Q000201:enzymology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; allergic rhinitis; insertion/deletion gene polymorphism; meta-analysis