title: Light transport in turbid media with non-scattering, low-scattering and high absorption heterogeneities based on hybrid simplified spherical harmonics with radiosity model.
abstract: Modeling light propagation in the whole body is essential and necessary for optical imaging. However, non-scattering, low-scattering and high absorption regions commonly exist in biological tissues, which lead to inaccuracy of the existing light transport models. In this paper, a novel hybrid light transport model that couples the simplified spherical harmonics approximation (SPN) with the radiosity theory (HSRM) was presented, to accurately describe light transport in turbid media with non-scattering, low-scattering and high absorption heterogeneities. In the model, the radiosity theory was used to characterize the light transport in non-scattering regions and the SPN was employed to handle the scattering problems, including subsets of low-scattering and high absorption. A Neumann source constructed by the light transport in the non-scattering region and formed at the interface between the non-scattering and scattering regions was superposed into the original light source, to couple the SPN with the radiosity theory. The accuracy and effectiveness of the HSRM was first verified with both regular and digital mouse model based simulations and a physical phantom based experiment. The feasibility and applicability of the HSRM was then investigated by a broad range of optical properties. Lastly, the influence of depth of the light source on the model was also discussed. Primary results showed that the proposed model provided high performance for light transport in turbid media with non-scattering, low-scattering and high absorption heterogeneities.
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China ; These authors contributed equally to this work.
authors.forename: Defu
authors.initials: D
authors.lastname: Yang
authors.forename: Xueli
authors.initials: X
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Peng
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Wang
authors.forename: Jorge
authors.initials: J
authors.lastname: Ripoll
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jimin
authors.initials: J
authors.lastname: Liang
keywords: (170.3660) Light propagation in tissues; (170.6935) Tissue characterization; (170.7050) Turbid media