title: Development of a fast capillary electrophoresis-time-of-flight mass spectrometry method for the speciation of organotin compounds under separation conditions of high electrical field strengths.
abstract: A novel approach has been developed for the separation of organotin species with capillary electrophoresis hyphenated to time-of-flight mass spectrometry. It has been applied to the development of a method for the determination and speciation of organotin compounds namely, dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPT) and triphenyltin (TPT) in water samples. Experiments were made with a special laboratory constructed CE instrument. A non-aqueous buffer system compatible with TOF-MS has been developed using ammonium acetate-acetic acid (50 mM and 1 M) in acetonitrile: methanol (80:20). The total analysis time is less than 3 min for these compounds under the conditions developed. The method has been applied successfully to the determination of these compounds in river water samples. Detection limits of the CE-TOF-MS method were between 1 and 8×10(-7) M, and between 2 and 11×10(-9) M (0.46 to 3.2 µg L(-1)) when used in conjunction with solid phase extraction. The short analysis time as well as good sensitivity and selectivity make it a useful approach for the fast screening of organotin compounds.
authors.affiliation: University of Regensburg, Institute for Analytical Chemistry, Chemo- and Biosensors, 93040 Regensburg, Germany.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Malik
authors.forename: Marco
authors.initials: M
authors.lastname: Grundmann
authors.forename: Frank-Michael
authors.initials: FM
authors.lastname: Matysik
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods; D005618:Fresh Water / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D009947:Organotin Compounds / Q000302:isolation & purification*; D052616:Solid Phase Extraction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013997:Time Factors; D014220:Trialkyltin Compounds / Q000302:isolation & purification*; D014874:Water Pollutants, Chemical / Q000302:isolation & purification*
chemical_list: D009947:Organotin Compounds; D014220:Trialkyltin Compounds; D014874:Water Pollutants, Chemical; C056189:di-n-butyltin; C063612:diphenyltin; C011559:tributyltin; C030665:triphenyltin
keywords: Capillary electrophoresis; DBT; DPT; Dibutyltin; Diphenyltin; Speciation analysis; TBT; TPT; Time-of-flight mass spectrometry; Tributyltin; Triphenyltin; Water samples