title: Cdc48: a swiss army knife of cell biology.
abstract: Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.
authors.affiliation: Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA.
authors.forename: Guem Hee
authors.initials: GH
authors.lastname: Baek
authors.forename: Haili
authors.initials: H
authors.lastname: Cheng
authors.forename: Vitnary
authors.initials: V
authors.lastname: Choe
authors.forename: Xin
authors.initials: X
authors.lastname: Bao
authors.forename: Jia
authors.initials: J
authors.lastname: Shao
authors.forename: Shiwen
authors.initials: S
authors.lastname: Luo
authors.forename: Hai
authors.initials: H
authors.lastname: Rao