title: Contrast enhanced ultrasonography prediction of cystic renal mass in comparison to histopathology.
abstract: OBJECTIVE
  To investigate the value of contrast-enhanced ultrasonography (CEUS) in histologic subtype prediction of cystic renal mass.
  
  
  METHODS
  Eighty-seven cystic renal masses were scanned by CEUS, and the CEUS findings and pathological results were recorded. The CEUS features of different histologic subtype cystic renal masses were analyzed and compared.
  
  
  RESULTS
  Among 87 renal cystic masses, 63 masses were malignant and 24 were benign. CEUS characteristics of benign and malignant cystic renal masses were significantly different. Different subtype cystic renal cell carcinoma had different CEUS imaging appearances. Multilocular cystic renal cell carcinomas (MCRCC) were more likely to be of Bosniak classification III. Clear cell renal cell carcinomas (CCRCC) were significantly more likely to appear as a multilocular cystic pattern combined with Bosniak classification IV. Cystic papillary renal cell carcinomas (PRCC) were more likely to appear as an unilocular cystic pattern combined with Bosniak classification IV. MCRCC combined with benign cystic masses were more likely to be classified as Bosniak classification III, which was significantly different from CCRCCs and PRCCs.
  
  
  CONCLUSIONS
  CEUS can be helpful in differentiating MCRCCs and benign cystic masses from CCRCCs and PRCCs. CEUS might be useful in histologic subtype prediction and clinical management of cystic renal mass.
authors.affiliation: Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Jihui
authors.initials: J
authors.lastname: Hao
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage / Q000627:therapeutic use*; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D052177:Kidney Diseases, Cystic / Q000000981:diagnostic imaging*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Kidney neoplasms; contrast agent; cystic mass; ultrasonography