title: De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
abstract: Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3 )2 (OH)2 (MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom); Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Farrer
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Butler
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: McQuitty
authors.forename: Abraha
authors.initials: A
authors.lastname: Habtemariam
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wang
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D006147:Guanine / Q000737:chemistry*; D008024:Ligands; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry*; D026082:Singlet Oxygen
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D026082:Singlet Oxygen; D010984:Platinum; D006147:Guanine
keywords: antitumor agents; bioinorganic chemistry; guanine oxidation; photoactivation; singlet oxygen