title: Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients.
abstract: OBJECTIVE
  The validity of our proposed lobe-specific regional lymph node stations (LSRLNS) was evaluated as a method for navigation during lymphadenectomy in patients with early stage non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 725 NSCLC patients with c-T2N1M0 or less extensive disease who had undergone a curative operation with complete mediastinal lymph node dissection (MLND) were studied. The LSRLNS were #2, #3, #4 and #10 for the right upper lobe, #11i, #11s, #7 and #8 for the right lower lobe, #4, #5 and #6 for the left superior division, #11, #5 and #7 for the left lingular division and #11, #7 and #8 for the left lower lobe.
  
  
  RESULTS
  If the LSRLNS were used for pathological examinations during surgery, 599 p-N0 and 39 p-N1 patients diagnosed with no metastasis would have been subjected to a selective MLND, while 20 p-N1 and 65 p-N2 patients who had a diagnosis of metastasis would have been navigated to a complete MLND. Two p-N2 patients with a diagnosis of no metastasis would have inappropriately undergone a selective MLND, resulting in the false negative rate at 0.3 %.
  
  
  CONCLUSIONS
  Intra-operative pathological examination using our LSRLNS may accurately reveal the status of metastasis, and appropriately lead to a selective or complete MLND in patients with c-T2N1M0 or less extensive disease.
authors.affiliation: Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan, smiyoshi@md.okayama-u.ac.jp.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shien
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyooka
authors.forename: Kentaroh
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Soh
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Masaomi
authors.initials: M
authors.lastname: Yamane
authors.forename: Takahiro
authors.initials: T
authors.lastname: Oto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D055815:Young Adult