title: Microreactors with integrated UV/Vis spectroscopic detection for online process analysis under segmented flow.
abstract: Combining reaction and detection in multiphase microfluidic flow is becoming increasingly important for accelerating process development in microreactors. We report the coupling of UV/Vis spectroscopy with microreactors for online process analysis under segmented flow conditions. Two integration schemes are presented: one uses a cross-type flow-through cell subsequent to a capillary microreactor for detection in the transmission mode; the other uses embedded waveguides on a microfluidic chip for detection in the evanescent wave field. Model experiments reveal the capabilities of the integrated systems in real-time concentration measurements and segmented flow characterization. The application of such integration for process analysis during gold nanoparticle synthesis is demonstrated, showing its great potential in process monitoring in microreactors operated under segmented flow.
authors.affiliation: Laboratory of Chemical Reactor Engineering, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. T.A.Nijhuis@tue.nl.
authors.forename: Jun
authors.initials: J
authors.lastname: Yue
authors.forename: Floris H
authors.initials: FH
authors.lastname: Falke
authors.forename: Jaap C
authors.initials: JC
authors.lastname: Schouten
authors.forename: T Alexander
authors.initials: TA
authors.lastname: Nijhuis
mesh_terms: D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D009862:Online Systems; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D018511:Systems Integration; D013997:Time Factors
chemical_list: D006046:Gold