title: Pimarane diterpenes from the Arctic fungus Eutypella sp. D-1.
abstract: Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3-4). The structures of 1 and 2 were elucidated from spectroscopic data (nuclear magnetic resonance, mass spectrometry and infrared). These compounds were evaluated for cytotoxic activity against seven human tumor cell lines. Compound 2 showed a range of cytotoxicity between 3.31 and 44.1 μM. Compound 1 exhibited antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
authors.affiliation: College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Lu
authors.affiliation: 1] College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China [2] School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
authors.forename: Jing-Tang
authors.initials: JT
authors.lastname: Liu
authors.affiliation: College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Liu
authors.affiliation: College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.affiliation: College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Jiao
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zheng
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001110:Arctic Regions; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; C587977:libertellenone G; C587978:libertellenone H