title: Hemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides.
abstract: Hemolytik (http://crdd.osdd.net/raghava/hemolytik/) is a manually curated database of experimentally determined hemolytic and non-hemolytic peptides. Data were compiled from a large number of published research articles and various databases like Antimicrobial Peptide Database, Collection of Anti-microbial Peptides, Dragon Antimicrobial Peptide Database and Swiss-Prot. The current release of Hemolytik database contains ∼3000 entries that include ∼2000 unique peptides whose hemolytic activities were evaluated on erythrocytes isolated from as many as 17 different sources. Each entry in Hemolytik provides comprehensive information about a peptide, like its name, sequence, origin, reported function, property such as chirality, types (linear and cyclic), end modifications as well as details pertaining to its hemolytic activity. In addition, tertiary structure of each peptide has been predicted, and secondary structure states have been assigned. To facilitate the scientific community, a user-friendly interface has been developed with various tools for data searching and analysis. We hope, Hemolytik will be useful for researchers working in the field of designing therapeutic peptides.
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India and Cell Biology and Immunology Division, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.forename: Anshika
authors.initials: A
authors.lastname: Joshi
authors.forename: Priya
authors.initials: P
authors.lastname: Anand
authors.forename: Abhishek
authors.initials: A
authors.lastname: Tuknait
authors.forename: Deepika
authors.initials: D
authors.lastname: Mathur
authors.forename: Grish C
authors.initials: GC
authors.lastname: Varshney
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D030562:Databases, Protein; D006461:Hemolysis; D053878:Hemolytic Agents / Q000737:chemistry / Q000633:toxicity*; D020407:Internet; D010455:Peptides / Q000737:chemistry / Q000633:toxicity*; D012984:Software
chemical_list: D053878:Hemolytic Agents; D010455:Peptides