title: Changes in well-being and quality of life in a randomized trial comparing dynamic psychotherapy and pharmacotherapy for major depressive disorder.
abstract: BACKGROUND
  Major depressive disorder (MDD) is associated with a decrease in quality of life (QOL) and well-being. Therefore, researchers are increasingly complementing traditional symptom measurements with QOL and well-being assessments in order to broaden the evaluation of treatment outcomes. The current prospective study investigated the effectiveness of supportive-expressive therapy (SET), antidepressant medication (MED) and placebo (PBO) in improving QOL and well-being in patients with MDD.
  
  
  METHODS
  Data from a randomized controlled trial (trial registration: NCT00043550) comparing SET, MED and PBO for the treatment of depression (N=156) were analyzed. Outcome measures addressed patients' QOL and physical and mental well-being. Changes in outcomes were assessed across and between treatments using linear mixed models.
  
  
  RESULTS
  Across treatments, patients showed significant improvement in QOL and mental and physical health measures, as well as a reduction in interpersonal distress and depressive and anxiety symptoms (p≤.002 for all measures). Those changes were not only the products of a decrease in depressive symptoms, but also predicted subsequent reduction in symptoms. No significant differences were found between the three treatment conditions.
  
  
  CONCLUSIONS
  The limitation is the study's moderate sample size.
  
  
  CONCLUSIONS
  Current treatments for depression significantly improve patients' QOL and well-being. No significant differences were found between the three conditions examined in this study. The current study highlights the role of well-being in predicting subsequent symptomatic change.
authors.affiliation: The Derner Institute of Advanced Psychological Studies, Adelphi University, United States. Electronic address: sigalzil@gmail.com.
authors.forename: Sigal
authors.initials: S
authors.lastname: Zilcha-Mano
authors.forename: Ulrike
authors.initials: U
authors.lastname: Dinger
authors.forename: Kevin S
authors.initials: KS
authors.lastname: McCarthy
authors.forename: Marna S
authors.initials: MS
authors.lastname: Barrett
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Barber
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D064889:Psychotherapy, Psychodynamic / Q000379:methods; D011788:Quality of Life / Q000523:psychology*; D020280:Sertraline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline
keywords: Depression; Psychodynamic psychotherapy; Quality of life; Secondary outcomes; Well-being