title: Routine histopathologic characteristics can predict oncotype DX(TM) recurrence score in subsets of breast cancer patients.
abstract: This study assessed whether routine pathologic parameters could predict Oncotype DX(TM) recurrence score (RS) in 72 breast cancers diagnosed from 2008-2012. Comparing patients with low RS (0-17) vs. intermediate RS (18-30) vs. high RS (>30), the mean Nottingham score increased (5.5 vs. 6.3 vs. 7.2, respectively, p = .001) and the mean PR Allred score decreased (6.7 vs. 4.9 vs. 3.3, respectively, p = .001). A high RS was least likely for low-grade tumors (0% had high RS, p = .005), and strong PR positivity (9% had high RS, p = .017). A low RS was least likely for cancers that were both high grade and PR weak/negative.
authors.affiliation: Radiation Oncology Department, NY Methodist Hospital, Weill Medical College of Cornell University, Brooklyn, New York, USA,1.
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: Mattes
authors.forename: Justin M
authors.initials: JM
authors.lastname: Mann
authors.forename: Hani
authors.initials: H
authors.lastname: Ashamalla
authors.forename: Ajay
authors.initials: A
authors.lastname: Tejwani
mesh_terms: D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D003661:Decision Support Techniques; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human