title: The dual role of IRF8 in cancer immunosurveillance.
abstract: For a long time, the transcription factor interferon-regulatory factor 8 (IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its fundamental relevance in multiple aspects of cancer immunosurveillance.
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine; Istituto Superiore di Sanità; Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Schiavoni
authors.forename: Lucia
authors.initials: L
authors.lastname: Gabriele
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mattei
keywords: IRF-8; crosstalk; immunoenvironment; melanoma; tumor suppressor gene