title: Clinical characteristics of Nocardia infection in patients with rheumatic diseases.
abstract: Although Nocardiosis has considerable recurrence and mortality rates, characteristics and risk factors of Nocardia infection have not been assessed in patients with rheumatic diseases. Here, we examined the characteristics and risk factors of Nocardia infection in rheumatic disease patients in our hospital. Ten rheumatic disease patients who developed Nocardia infection were identified by retrospectively reviewing the medical records. Possible predisposing factors for Nocardia infection were high-dose glucocorticoid treatment, concomitant use of immunosuppressants, preexisting pulmonary diseases, and diabetes mellitus. All patients had pulmonary Nocardiosis, and six of them had disseminated Nocardiosis when their pulmonary lesions were identified.
authors.affiliation: Department of Allergy and Clinical Immunology, Chiba University Hospital, 1-8-1 Inohana, Chiba, Chiba City 260-8677, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Yamagata
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirose
authors.forename: Kei
authors.initials: K
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000302:isolation & purification; D009617:Nocardia Infections / Q000150:complications* / Q000175:diagnosis*; D012216:Rheumatic Diseases / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents