title: Antiangiogenic effects of marine sponge derived compounds on cancer.
abstract: The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis and its mechanistic pathways are critical target for cancer therapy. Recently, marine derived compounds, plays major role in cancer research. Several sponge derived compounds such as alkaloids, terpenes, macrocylic lactone and polyketide are leading drugs in the treatment of different types of diseases including cancer. Those marine sponge compounds inhibit cancer cell proliferation and tumor angiogenesis. Hence, this review sheds light on angiogenic regulators and marine sponge derived antiangiogenic compounds for cancer.
authors.affiliation: Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea.
authors.forename: Kalimuthu
authors.initials: K
authors.lastname: Senthilkumar
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Venkatesan
authors.forename: Panchanathan
authors.initials: P
authors.lastname: Manivasagan
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D011161:Porifera / Q000737:chemistry*; D011379:Prognosis; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents
keywords: Alkaloids; Anti-angiogenesis; Cancer; Metastasis; Polyketide; Sponge