title: Fine-tuning the antimicrobial profile of biocompatible gold nanoparticles by sequential surface functionalization using polyoxometalates and lysine.
abstract: Antimicrobial action of nanomaterials is typically assigned to the nanomaterial composition, size and/or shape, whereas influence of complex corona stabilizing the nanoparticle surface is often neglected. We demonstrate sequential surface functionalization of tyrosine-reduced gold nanoparticles (AuNPs(Tyr)) with polyoxometalates (POMs) and lysine to explore controlled chemical functionality-driven antimicrobial activity. Our investigations reveal that highly biocompatible gold nanoparticles can be tuned to be a strong antibacterial agent by fine-tuning their surface properties in a controllable manner. The observation from the antimicrobial studies on a gram negative bacterium Escherichia coli were further validated by investigating the anticancer properties of these step-wise surface-controlled materials against A549 human lung carcinoma cells, which showed a similar toxicity pattern. These studies highlight that the nanomaterial toxicity and biological applicability are strongly governed by their surface corona.
authors.affiliation: NanoBiotechnology Research Laboratory, School of Applied Sciences, Royal Melbourne Institute of Technology University, Melbourne, Victoria, Australia.
authors.forename: Hemant K
authors.initials: HK
authors.lastname: Daima
authors.forename: P R
authors.initials: PR
authors.lastname: Selvakannan
authors.forename: Ravi
authors.initials: R
authors.lastname: Shukla
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Bhargava
authors.forename: Vipul
authors.initials: V
authors.lastname: Bansal
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
chemical_list: D000900:Anti-Bacterial Agents; D006046:Gold; D008239:Lysine; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates