title: Nutritional management of insulin resistance in nonalcoholic fatty liver disease (NAFLD).
abstract: Nonalcoholic fatty liver disease (NAFLD) is an emerging global health concern. It is the most common form of chronic liver disease in Western countries, affecting both adults and children. NAFLD encompasses a broad spectrum of fatty liver disease, ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH), and is strongly associated with obesity, insulin resistance, and dyslipidemia. First-line therapy for NAFLD includes weight loss achieved through diet and physical activity. However, there is a lack of evidenced-based dietary recommendations. The American Diabetes Association's (ADA) recommendations that aim to reduce the risk of diabetes and cardiovascular disease may also be applicable to the NAFLD population. The objectives of this review are to: (1) provide an overview of NAFLD in the context of insulin resistance, and (2) provide a rationale for applying relevant aspects of the ADA recommendations to the nutritional management of NAFLD.
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. beth.conlon@phd.einstein.yu.edu.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Conlon
authors.forename: Jeannette M
authors.initials: JM
authors.lastname: Beasley
authors.forename: Karin
authors.initials: K
authors.lastname: Aebersold
authors.forename: Sunil S
authors.initials: SS
authors.lastname: Jhangiani
authors.forename: Judith
authors.initials: J
authors.lastname: Wylie-Rosett
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000517:prevention & control; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D019317:Evidence-Based Medicine; D005234:Fatty Liver / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D008107:Liver Diseases; D018977:Micronutrients / Q000008:administration & dosage; D009043:Motor Activity; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications / Q000178:diet therapy; D016032:Randomized Controlled Trials as Topic; D064167:Recommended Dietary Allowances; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D018977:Micronutrients