title: B-Raf mutation: a key player in molecular biology of cancer.
abstract: B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common.
authors.affiliation: Cancer Molecular Pathology Group, Griffith Health Institute, Griffith University, Gold Coast, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
authors.forename: A
authors.initials: A
authors.lastname: Salajegheh
authors.forename: R A
authors.initials: RA
authors.lastname: Smith
authors.forename: A K-Y
authors.initials: AK
authors.lastname: Lam
mesh_terms: D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: B-Raf; BRAF; Colorectal cancer; Melanoma; Mutation; Thyroid cancer