title: Rhus coriaria ameliorates insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) rats.
abstract: We have investigated the effect of methanolic extract of Rhus coriaria (RC) on hyperinsulinemia, glucose intolerance and insulin sensitivity in non-insulin-dependent diabetes mellitus (NIDDM) rats. NIDDM was induced by single intraperitoneal injection of streptozotocin (STZ, 100 mg/kg) to 2 days old rat pups. RC (200 mg/kg and 400 mg/kg) was administered orally once a day for 5 weeks after the animals were confirmed diabetic (i.e, 90 days after STZ injection). A group of citrate control rats were also maintained which has received citrate buffer on the 2nd day of their birth. There was a significant increase in blood glucose, glycosylated hemoglobin (HbA1c) and serum insulin levels were observed in NIDDM control rats. Treatment with RC reduced the elevated levels of blood glucose, HbA1c and insulin in the NIDDM rats. An oral glucose tolerance test (OGTT) was also performed in the same groups, in which we found a significant improvement in glucose tolerance in the rats treated with RC. The insulin sensitivity was assessed for both peripheral insulin resistance and hepatic insulin resistance. RC treatment significantly improved insulin sensitivity index (K(ITT)) which was significantly decreased in NIDDM control rats. There was significant rise in homeostasis model assessment of insulin resistance (HOMA-R) in NIDDM control rats whereas RC treatment significantly prevented the rise in HOMA-R in NIDDM treated rats. Our data suggest that methanolic extract of RC significantly delayed the onset of hyperinsulinemia and glucose intolerance and improved insulin sensitivity in NIDDM rats.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, (Hamdard Nagar), New Delhi-110 062, India. anwertarique25@yahoo.co.in
authors.forename: Tarique
authors.initials: T
authors.lastname: Anwer
authors.forename: Manju
authors.initials: M
authors.lastname: Sharma
authors.forename: Gyas
authors.initials: G
authors.lastname: Khan
authors.forename: Muzaffar
authors.initials: M
authors.lastname: Iqbal
authors.forename: Mohammad Sajid
authors.initials: MS
authors.lastname: Ali
authors.forename: Mohammad Sarfaraz
authors.initials: MS
authors.lastname: Alam
authors.forename: Mohammed Mohsen
authors.initials: MM
authors.lastname: Safhi
authors.forename: Nakul
authors.initials: N
authors.lastname: Gupta
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D018149:Glucose Intolerance / Q000188:drug therapy; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D029045:Rhus / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts