title: Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome.
abstract: BACKGROUND
  To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity.
  
  
  METHODS
  In this retrospective, matched control study, the ICSI-ET outcome of sixty-two patients (Group I) with intramural fibroid (mean diameter <7 cm) and normal endometrial cavity demonstrated by office hysteroscopy was compared with matched-control group of patients (n = 301) with no fibroid (Group II). The diagnosis of fibroids was done by transvaginal ultrasonography.
  
  
  RESULTS
  The mean age in fibroid group was 32.66 +/- 5.30 while this figure was 32.95 +/- 3.98 in control group. The clinical pregnancy rate was significantly lower in the fibroid group although fibroids not distorting the uterine cavity (25.8% vs. 39.9%, p = 0.04). In fibroid group the implantation rate was significantly lower than control group (20.97 +/- 37.93 vs.32.89 +/- 43.18%, p = 0.04). However, spontaneous abortion rate was higher in fibroid group but it did not reach the significant level (12.5% vs. 9.2%, p > 0.05).
  
  
  CONCLUSIONS
  Women having intramural leiomyomas not encroaching on the uterine cavity have unfavorable ICSI/ET outcomes comparable to those of women without such leiomyomas. Therefore, myomectomy may be a good option for such patients with intramural fibroids even they do not have any endometrial distortion.
authors.affiliation: Department of Obstetrics and Gynecology, Farabi ART Center, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey. drsuleymanguven@yahoo.com.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Cavit
authors.initials: C
authors.lastname: Kart
authors.forename: Mesut A
authors.initials: MA
authors.lastname: Unsal
authors.forename: Ersan
authors.initials: E
authors.lastname: Odaci
mesh_terms: D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000628:therapy; D007889:Leiomyoma / Q000150:complications* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging