title: Effect of SAMITAL® in the treatment of chemotherapy-induced mucositis in adult oncohematological patients.
abstract: OBJECTIVE
  We sought to evaluate the efficacy and safety of SAMITAL(®) (Indena SpA, Milan, Italy), a highly standardized botanical formulation, in reducing mucositis in patients undergoing treatment for hematological malignancies.
  
  
  METHODS
  In this observational, uncontrolled study, a total of 25 consecutively enrolled patients (19 males, aged 18-74 years) with chemotherapy-induced mucositis were compassionately treated orally with SAMITAL (three to four times per day) for 4-22 days per cycle.
  
  
  RESULTS
  Patients demonstrated clinically relevant reductions in WHO mucositis grade with a reduction in pain, mucosal erosions, bleeding, dysphagia/feeding impairment and improvements in quality of life. SAMITAL was well tolerated and no local or systemic pharmacological, allergic, toxic or synergistic/antagonistic side effects were reported. Of note, SAMITAL also showed efficacy when administered prophylactically.
  
  
  CONCLUSIONS
  These results add weight to previous experiences with SAMITAL. However, randomized, placebo-controlled clinical trials will need to confirm the suitability of SAMITAL for use in the treatment of mucositis.
authors.affiliation: Department of Medicine, Hospital Clinico Regional de Valdivia, Valdivia, Chile.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Bertoglio
authors.forename: Susana
authors.initials: S
authors.lastname: Calderón
authors.forename: Blaz
authors.initials: B
authors.lastname: Lesina
authors.forename: Lilian
authors.initials: L
authors.lastname: Pilleux
authors.forename: Paolo
authors.initials: P
authors.lastname: Morazzoni
authors.forename: Antonella
authors.initials: A
authors.lastname: Riva
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Ronchi
authors.forename: Walter
authors.initials: W
authors.lastname: Cabri
authors.forename: Giovanna
authors.initials: G
authors.lastname: Petrangolini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; C580632:samital