title: Orbital solitary fibrous tumor with multinucleate giant cells: case report of an unusual finding in an uncommon tumor.
abstract: Solitary fibrous tumor (SFT) is a rare soft-tissue neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. Orbital involvement by SFT is uncommon. Giant cells are extremely rare to be seen in a SFT and have been described to be immunoreactive for CD34. We present a case of orbital SFT with multinucleate giant cells expressing CD68 and lacking immunoreactivity for CD34. The differential diagnosis is discussed.
authors.affiliation: Ocular Pathology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India.
authors.forename: Kaustubh
authors.initials: K
authors.lastname: Mulay
authors.forename: Santosh G
authors.initials: SG
authors.lastname: Honavar
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005260:Female; D015726:Giant Cells / Q000737:chemistry / Q000166:cytology*; D006257:Head / Q000000981:diagnostic imaging; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008853:Microscopy; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D054364:Solitary Fibrous Tumors / Q000175:diagnosis* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule