title: One-pot chemoenzymatic multicomponent synthesis of thiazole derivatives.
abstract: A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, Zhejing, China. huizheng@hznu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Yi-Jia
authors.initials: YJ
authors.lastname: Mei
authors.forename: Kui
authors.initials: K
authors.lastname: Du
authors.forename: Xian-Ting
authors.initials: XT
authors.lastname: Cao
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006571:Heterocyclic Compounds / Q000737:chemistry*; D013552:Swine; D013844:Thiazoles / Q000737:chemistry*; D014357:Trypsin / Q000378:metabolism
chemical_list: D006571:Heterocyclic Compounds; D013844:Thiazoles; D014357:Trypsin