title: [IMSIII, SYNTHESIS, and MR-RESCUE studies: the end of endovascular treatment for stroke?].
abstract: Last March, in a single issue New England Journal of Medicine published 3 studies that evaluated the efficacy of endovascular treatment for ischemic stroke, leading to a heated controversy between neurologists and interventional neuroradiologists. The negative results have resulted in numerous reviews pointing out serious methodological defects. In this article, we analyze the outcomes of thrombolytic treatment for stroke and discuss the strengths and weaknesses of the three above-mentioned studies. Despite the negative results, these studies can point the way for new trials that will justify this treatment modality that is backed up by scientific evidence.
authors.affiliation: Sección de Neurorradiología Diagnóstica y Terapéutica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.affiliation: Servicio de Neurología, Complejo Hospitalario Universitario de Albacete, Albacete, España. Electronic address: fco.hdez.fdez@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Hernández-Fernández
mesh_terms: D002986:Clinical Trials as Topic; D057510:Endovascular Procedures; D006801:Humans; D020521:Stroke / Q000628:therapy*; D017131:Thrombectomy; D015912:Thrombolytic Therapy
keywords: Ictus; Mechanical thrombectomy; Recanalización; Recanalization; Stentrievers; Stroke; Thrombolysis; Trombectomía mecánica; Trombólisis