title: Optimal postoperative treatment for composite laryngeal small cell carcinoma.
abstract: Small cell carcinoma (SmCC) most commonly occurs in the lung and rarely arises from the head and neck region. Further, composite SmCC is extremely rare. Therefore, no postoperative treatment strategy has been established. We report a 59-year-old male patient referred to our outpatient clinic for further examination and treatment of a laryngeal tumor. Biopsy from the tumor revealed squamous cell carcinoma (SCC). The preoperative diagnosis was supraglottic SCC (T3N2bM0), and total laryngectomy and bilateral neck dissection were performed. Pathological examination revealed 2 individual cancer components: SmCC and SCC. Postoperative chemoradiotherapy (2 courses of cisplatin (CDDP) and etoposide (VP-16)) was indicated. Following the postoperative chemoradiotherapy, 2 courses of adjuvant chemotherapy were administered. The patient is currently alive with no evidence of disease at 36 months following the completion of therapy. Postoperative chemoradiotherapy and adjuvant chemotherapy are optimal treatment strategies for laryngeal composite SmCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tokai University, School of Medicine, Isehara 259-1193, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ebisumoto
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakai
authors.forename: Kenji
authors.initials: K
authors.lastname: Okami
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Sugimoto
authors.forename: Kosuke
authors.initials: K
authors.lastname: Saito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iida