title: The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84.
abstract: Splenic sympathetic nerve activity (SNA) modulates cellular immune functions such as splenic natural killer cell activity. Lactobacillus pentosus strain S-PT84 enhances splenic natural killer cell activity. Here, we examined whether S-PT84 affects splenic natural killer activity through splenic SNA in BALB/c mice. Splenic SNA was significantly decreased following the administration of S-PT84. This phenomenon was inhibited by pretreatment with thioperamide (histamine H3 receptor antagonist), suggesting that S-PT84 directly affected splenic SNA. Thioperamide also inhibited the increase in splenic natural killer activity by S-PT84. Thus, the change in splenic natural killer activity by S-PT84 may be partially modulated through SNA.
authors.affiliation: aInstitute for Health Care Science, Suntory Wellness Limited bANBAS Corporation, Osaka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Izumo
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Maekawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horii
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fujisaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ono
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology*; D007778:Lactobacillus / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology* / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000502:physiology*