title: Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences.
abstract: Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X(2), p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.
authors.affiliation: Facultad de Medicina, Universidad Autónoma del Estado de Morelos (UAEM). Cuernavaca, Morelos, México.
authors.forename: Armando
authors.initials: A
authors.lastname: Herrera-Arellano
authors.forename: Edgar O
authors.initials: EO
authors.lastname: López-Villegas
authors.forename: Aida V
authors.initials: AV
authors.lastname: Rodríguez-Tovar
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamilpa
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez-Ferrer
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Martínez-Rivera
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D032322:Solanum / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012503:Saponins; D007654:Ketoconazole
keywords: Solanum chrysotrichum; alternative therapy; antifungal activity; saponins; vulvovaginal candidiasis