title: Understanding the role of mitochondria in the pathogenesis of chronic pain.
abstract: Chronic pain is a major public health problem. Mitochondria play important roles in a myriad of cellular processes and mitochondrial dysfunction has been implicated in multiple neurological disorders. This review aims to provide an insight into advances in understanding of the role of mitochondrial dysfunction in the pathogenesis of chronic pain. The results show that the five major mitochondrial functions (the mitochondrial energy generating system, reactive oxygen species generation, mitochondrial permeability transition pore, apoptotic pathways and intracellular calcium mobilisation) may play critical roles in neuropathic and inflammatory pain. Therefore, protecting mitochondrial function would be a promising strategy to alleviate or prevent chronic pain states. Related chronic inflammatory and neuropathic pain models, as well as the spectral characteristics of current fluorescent probes to detect mitochondria in pain studies, are also discussed.
authors.affiliation: Department of Human Anatomy, Histology and Embryology, K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, , Xi'an, China.
authors.forename: Bing-dong
authors.initials: BD
authors.lastname: Sui
authors.forename: Tian-qi
authors.initials: TQ
authors.lastname: Xu
authors.forename: Jie-wei
authors.initials: JW
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Chen-xi
authors.initials: CX
authors.lastname: Zheng
authors.forename: Bao-lin
authors.initials: BL
authors.lastname: Guo
authors.forename: Ya-yun
authors.initials: YY
authors.lastname: Wang
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Yang
mesh_terms: D017209:Apoptosis; D059350:Chronic Pain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D008954:Models, Biological; D009437:Neuralgia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species
keywords: Chemical Pathology; Neurophysiology