title: Glycine receptors and brain development.
abstract: Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotransmission. Moreover, GlyRs are present since early stages of brain development and might influence this process. Here, we discuss the current state of the art regarding GlyRs during embryonic and postnatal brain development in light of recent findings about the cellular and molecular mechanisms that control brain development.
authors.affiliation: Cell Physiology, BIOMED Research Institute, Hasselt University Diepenbeek, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Neurosciences, Centre Hospitalier Universitaire Sart Tilman, University of Liége Liège, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Research, Centre Hospitalier Universitaire Sart Tilman, University of Liège Liège, Belgium.
authors.forename: Ariel
authors.initials: A
authors.lastname: Avila
authors.forename: Laurent
authors.initials: L
authors.lastname: Nguyen
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Rigo
keywords: GlyRs; brain development; cortex; glycine; glycine receptors; hippocampus; interneurons; migration