title: Evaluation of the effect of one stage versus two stage full mouth disinfection on C-reactive protein and leucocyte count in patients with chronic periodontitis.
abstract: BACKGROUND
  Conventional non-surgical periodontal therapy is carried out in quadrant basis with 1-2 week interval. This time lag may result in re-infection of instrumented pocket and may impair healing. Therefore, a new approach to full-mouth non-surgical therapy to be completed within two consecutive days with full-mouth disinfection has been suggested. In periodontitis, leukocyte counts and levels of C-reactive protein (CRP) are likely to be slightly elevated, indicating the presence of infection or inflammation. The aim of this study is to compare the efficacy of one stage and two stage non-surgical therapy on clinical parameters along with CRP levels and total white blood cell (TWBC) count.
  
  
  METHODS
  A total of 20 patients were selected and were divided into two groups. Group 1 received one stage full mouth dis-infection and Group 2 received two stages FMD. Plaque index, sulcus bleeding index, probing depth, clinical attachment loss, serum CRP and TWBC count were evaluated for both the groups at baseline and at 1 month post-treatment.
  
  
  RESULTS
  The results were analyzed using the Student t-test. Both treatment modalities lead to a significant improvement of the clinical and hematological parameters; however comparison between the two groups showed no significant difference after 1 month.
  
  
  CONCLUSIONS
  The therapeutic intervention may have a systemic effect on blood count in periodontitis patients. Though one stage FMD had limited benefits over two stages FMD, the therapy can be accomplished in a shorter duration.
authors.affiliation: Department of Periodontics, Mamata Dental College and Hospital, Khammam, Andhra Pradesh, India.
authors.forename: Chandra Mohan
authors.initials: CM
authors.lastname: Pabolu
authors.forename: Ramesh Babu
authors.initials: RB
authors.lastname: Mutthineni
authors.forename: Srikanth
authors.initials: S
authors.lastname: Chintala
authors.lastname: Naheeda
authors.forename: Navya
authors.initials: N
authors.lastname: Mutthineni
keywords: C-reactive proteins; chronic periodontitis; one stage full mouth disinfection; total white blood cell count