title: Research status of the regulation of miRNA on BACE1.
abstract: MicroRNAs (miRNAs) are noncoding RNAs that are around 22 nucleotides in length. miRNAs play a key role in neuronal development, differentiation, and synaptic plasticity. An increasing amount of evidence indicates that miRNAs regulate the expression of β-site APP cleaving enzyme (BACE1), a key enzyme in Alzheimer's disease (AD) pathology. Changes in miRNA expression as a causal factor in AD have not been fully elucidated. We hypothesized that the abnormal expression of miRNAs may contribute to AD pathology, specifically through the regulation of BACE1.
authors.affiliation: Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yanyao
authors.initials: Y
authors.lastname: Deng
authors.forename: Yu
authors.initials: Y
authors.lastname: Ding
authors.forename: Deren
authors.initials: D
authors.lastname: Hou
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012106:Research
chemical_list: D035683:MicroRNAs; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human
keywords: Alzheimer's disease; pathogenesis; β-amyloid