title: The role of ligand coordination on the cytotoxicity of cationic quantum dots in HeLa cells.
abstract: The effect of ligand structure on the cytotoxicity of cationic CdSe/ZnS quantum dots (QDs) was systematically investigated using mono- and bidentate ligands. Monothiol-functionalized QDs are more cytotoxic than dithiol-functionalized QDs.
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Yi-Cheun
authors.initials: YC
authors.lastname: Yeh
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Saha
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Oscar R
authors.initials: OR
authors.lastname: Miranda
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D002412:Cations / Q000737:chemistry* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D053758:Nanoparticles / Q000737:chemistry; D009336:Necrosis; D045663:Quantum Dots / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002412:Cations; D056831:Coordination Complexes; D003603:Cytotoxins; D008024:Ligands; D013438:Sulfhydryl Compounds