title: Two new neutral copper(II) complexes with dipicolinic acid and 3-amino-1H-1,2,4-triazole formed under different reaction conditions: synthesis, characterization, molecular structures and DNA-binding studies.
abstract: Two Cu(II) complexes, [Cu₂(μ-atr)(pydc)₂(H₂O)₄]·5H₂O (1) and [Cu(atr)(pydc) (H₂O)]·H₂O (2), with pyridine-2,6-dicarboxylic acid (H₂pydc) and 3-amino-1H-1,2,4-triazole (atr), have been synthesized and characterized. The interaction ability of the both complexes with native calf thymus DNA (CT-DNA) has been monitored as a function of the metal complex-DNA molar ratio. UV-vis spectrophotometry, circular dichroism (CD), thermal denaturation studies, cyclic voltammetry (CV) and viscosity measurements. The intrinsic binding constants K(b) of complexes 1 and 2, with CT-DNA obtained from UV-vis absorption studies were 4.7 (±0. 1) × 10(4) and 9.5 (±0. 1) × 10(4) M(-1), respectively. Further investigation of interaction mode was performed using viscosity, cyclic voltammetry and T(m) of CT-DNA studies as well as CD study, indicating complexes bind to DNA via an intercalation mode.
authors.affiliation: Department of Chemistry, Yaz Branch, Islamic Azad University, Yazd, Iran. Electronic address: tabatabaee45@gmail.com.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Tabatabaee
authors.forename: Maryam
authors.initials: M
authors.lastname: Bordbar
authors.forename: Mitra
authors.initials: M
authors.lastname: Ghassemzadeh
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Tahriri
authors.forename: Marjan
authors.initials: M
authors.lastname: Tahrir
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mehri Lighvan
authors.forename: Bernhard
authors.initials: B
authors.lastname: Neumüller
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010848:Picolinic Acids / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*; D014783:Viscosity
chemical_list: C000591593:3-amino-1H-1,2,4-triazole; D009942:Organometallic Compounds; D010848:Picolinic Acids; D014230:Triazoles; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C004860:dipicolinic acid
keywords: 3-Amino-1H-1,2,4-triazole; CT-DNA; Copper complex; DNA-binding; Dipicolinic acid