title: Nutrigenetics, metabolic syndrome risk and personalized nutrition.
abstract: The metabolic syndrome (MetS) is a constellation of metabolic risk factors reflecting overnutrition and sedentary lifestyle and its increasing prevalence is reaching epidemic proportions. The importance of MetS lies in its close association with the risk of cardiometabolic disease. In this scenario, the principal goals of pharmacological therapy for these patients are to achieve and maintain an optimal cardiometabolic control, including lipids, blood glucose and blood pressure; in order to prevent and treat potential complications. Moreover nutrition has commonly been accepted as a cornerstone of treatment for MetS, with the expectation that an appropriate intake of energy and nutrients will improve its control. However the question arises as to whether dietary therapy may require a more personalised approach. In this regard improvements in genetic analysis have enhanced our understanding of the role of genetics in this dietrelated condition. In this review we will present recent data highlighting the importance of gene-nutrient interactions in the context of MetS risk.
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Phillips
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Rios
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
authors.affiliation: Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit. Avda. Menendez Pidal, s/n. 14004 Cordoba, Spain. pablopermar@yahoo.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Jimenez
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004032:Diet / Q000009:adverse effects / Q000379:methods / Q000639:trends*; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000235:genetics*; D054647:Nutrigenomics / Q000379:methods* / Q000639:trends; D009752:Nutritional Status / Q000502:physiology*; D057285:Precision Medicine / Q000379:methods / Q000639:trends*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids