title: Comparison of itraconazole, voriconazole, and posaconazole as oral antifungal prophylaxis in pediatric patients following allogeneic hematopoietic stem cell transplantation.
abstract: Oral antifungal prophylaxis with extended-spectra azoles is widely used in pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT), while controlled studies for oral antifungal prophylaxis after bone marrow transplantation in children are not available. This survey analyzed patients who had received either itraconazole, voriconazole, or posaconazole. We focused on the safety, feasibility, and initial data of efficacy in a cohort of pediatric patients and adolescents after high-dose chemotherapy and HSCT. Fifty consecutive pediatric patients received itraconazole, 50 received voriconazole, and 50 pediatric patients received posaconazole after HSCT as oral antifungal prophylaxis. The observation period lasted from the start of oral prophylactic treatment with itraconazole, voriconazole, or posaconazole until two weeks after terminating the oral antifungal prophylaxis. No incidences of proven or probable invasive mycosis were observed during itraconazole, voriconazole, or posaconazole treatment. A total of five possible invasive fungal infections occurred, two in the itraconazole group (4%) and three in the voriconazole group (6%). The percentage of patients with adverse events potentially related to clinical drugs were 14% in the voriconazole group, 12% in the itraconazole group, and 8% in the posaconazole group. Itraconazole, voriconazole, and posaconazole showed comparable efficacy as antifungal prophylaxis in pediatric patients after allogeneic HSCT.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, Hoppe-Seyler-St. 1, 72076, Tübingen, Germany, Michaela.Doering@med.uni-tuebingen.de.
authors.forename: M
authors.initials: M
authors.lastname: Döring
authors.forename: O
authors.initials: O
authors.lastname: Blume
authors.forename: S
authors.initials: S
authors.lastname: Haufe
authors.forename: U
authors.initials: U
authors.lastname: Hartmann
authors.forename: A
authors.initials: A
authors.lastname: Kimmig
authors.forename: C-P
authors.initials: CP
authors.lastname: Schwarze
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: R
authors.initials: R
authors.lastname: Handgretinger
authors.forename: I
authors.initials: I
authors.lastname: Müller
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D019072:Antibiotic Prophylaxis / Q000379:methods*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D014184:Transplantation, Homologous; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles