title: Effects of aged garlic extract on left ventricular diastolic function and fibrosis in a rat hypertension model.
abstract: Daily consumption of garlic is known to lower the risk of hypertension and ischemic heart disease. In this study, we examined whether aged garlic extract (AGE) prevents hypertension and the progression of compensated left ventricular (LV) hypertrophy in Dahl salt-sensitive (DS) rats. DS rats were randomly divided into three groups: those fed an 8% NaCl diet until 18 weeks of age (8% NaCl group), those additionally treated with AGE (8% NaCl + AGE group), and control rats maintained on a diet containing 0.3% NaCl until 18 weeks of age (0.3% NaCl group). AGE was administered orally by gastric gavage once a day until 18 weeks of age. LV mass was significantly higher in the 8% NaCl + AGE group than in the 0.3% NaCl group at 18 weeks of age, but significantly lower in the 8% NaCl + AGE group than in the 8% NaCl group. No significant differences were observed in systolic blood pressure (SBP) between the 8% NaCl and 8% NaCl + AGE groups at 12 and 18 weeks of age. LV end-diastolic pressure and pressure half-time at 12 and 18 weeks of age were significantly lower in the 8% NaCl + AGE group compared with the 8% NaCl group. AGE significantly reduced LV interstitial fibrosis at 12 and 18 weeks of age. Chronic AGE intake attenuated LV diastolic dysfunction and fibrosis without significantly decreasing SBP in hypertensive DS rats.
authors.affiliation: Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hara
authors.forename: Akiko
authors.initials: A
authors.lastname: Noda
authors.forename: Seiko
authors.initials: S
authors.lastname: Miyata
authors.forename: Makoto
authors.initials: M
authors.lastname: Minoshima
authors.forename: Mari
authors.initials: M
authors.lastname: Sugiura
authors.forename: Jun
authors.initials: J
authors.lastname: Kojima
authors.forename: Masafumi
authors.initials: M
authors.lastname: Otake
authors.forename: Mayuko
authors.initials: M
authors.lastname: Furukawa
authors.forename: Xian Wu
authors.initials: XW
authors.lastname: Cheng
authors.forename: Kohzo
authors.initials: K
authors.lastname: Nagata
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000284:Administration, Oral; D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000517:prevention & control; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D015150:Echocardiography, Doppler; D005355:Fibrosis; D005737:Garlic; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D020303:Rats, Inbred Dahl; D012306:Risk; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000517:prevention & control; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D010936:Plant Extracts