title: Symptomatic treatment of vestibular deficits: therapeutic potential of histamine H4 receptors.
abstract: Vestibular disorders display high prevalence and can severely impact the daily life. However, pharmacological options that would efficiently relieve the vertigo symptoms without side effects are still lacking. In the present review we briefly review the common history of histamine receptor modulation and the pharmacological therapy of vestibular disorders. We also discuss the recent demonstration of Histamine H4 Receptor mRNAs expression in Scarpa's ganglion of mammal and the potential use of specific H4R antagonists as vestibulomodulators. Additional original data confirm the expression of H4R proteins in the rat vestibular primary neurons, the neuromodulatory properties of specific H4R antagonists in vitro (inhibition of vestibular neuron excitability) as well as their efficacy to decrease vestibular deficits induced in different in animal models.
authors.affiliation: SENSORION, Montpellier, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Wersinger
authors.forename: Sophie
authors.initials: S
authors.lastname: Gaboyard-Niay
authors.forename: Cécile
authors.initials: C
authors.lastname: Travo
authors.forename: Enrique
authors.initials: E
authors.lastname: Soto
authors.forename: Adriana
authors.initials: A
authors.lastname: Baez
authors.forename: Rosario
authors.initials: R
authors.lastname: Vega
authors.forename: Aurore
authors.initials: A
authors.lastname: Brugeaud
authors.forename: Christian
authors.initials: C
authors.lastname: Chabbert
mesh_terms: D000818:Animals; D001621:Betahistine / Q000627:therapeutic use; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects*; D011968:Receptors, Histamine / Q000187:drug effects*; D000074040:Receptors, Histamine H4; D012027:Reflex, Vestibulo-Ocular
chemical_list: C418607:HRH4 protein, human; D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D001621:Betahistine
keywords: Ménière's disease; Vestibule; hair cells; histamine receptors; vertigo; vestibular neurons