title: Atypical RNAs in the coelacanth transcriptome.
abstract: Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms.
authors.affiliation: Department of Computer Science, Bioinformatics Group, University of Leipzig, Leipzig, Germany; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Nitsche
authors.forename: Gero
authors.initials: G
authors.lastname: Doose
authors.forename: Hakim
authors.initials: H
authors.lastname: Tafer
authors.forename: Mark
authors.initials: M
authors.lastname: Robinson
authors.forename: Nil Ratan
authors.initials: NR
authors.lastname: Saha
authors.forename: Marco
authors.initials: M
authors.lastname: Gerdol
authors.forename: Adriana
authors.initials: A
authors.lastname: Canapa
authors.forename: Steve
authors.initials: S
authors.lastname: Hoffmann
authors.forename: Chris T
authors.initials: CT
authors.lastname: Amemiya
authors.forename: Peter F
authors.initials: PF
authors.lastname: Stadler
mesh_terms: D000818:Animals; D001483:Base Sequence; D005399:Fishes / Q000235:genetics*; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism*; D012326:RNA Splicing / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000378:metabolism; D017423:Sequence Analysis, RNA; D059467:Transcriptome
chemical_list: D062085:RNA, Long Noncoding; D012313:RNA