title: Sustained antipsychotic effect of metacognitive training in psychosis: a randomized-controlled study.
abstract: Persistent psychotic symptoms represent a major challenge for psychiatric care. Basic research has shown that psychotic symptoms are associated with cognitive biases. Metacognitive training (MCT) aims at helping patients to become aware of these biases and to improve problem-solving. Fifty-two participants fulfilling diagnostic criteria of schizophrenia or schizoaffective disorders and persistent delusions and stabilized antipsychotic medication were enrolled in this study. Following baseline assessment patients were randomized either to treatment as usual (TAU) conditions or TAU+MCT. The intervention consisted of eight weekly 1-hour sessions (maximum: 8 hours). Participants were assessed at 8 weeks and 6-months later by blind assessors. Participants were assessed with the Psychotic Symptoms Rating Scales (PSYRATS) and the positive subscale of the PANSS. Between-group differences in post- and pre-test values were significant at a medium effect size in favor of the MCT for the PSYRATS delusion scale and the positive scale of the PANSS both at post and follow-up. The results of this study indicate that MCT training has a surplus antipsychotic effect for patients suffering from schizophrenia-related disorders who demonstrate only a partial response to antipsychotic treatment and that the effect of the intervention persists for at least 6 months after the intervention.
authors.affiliation: La Source, School of Nursing Sciences, University of Applied Sciences of Western Switzerland, avenue Vinet 30, 1004 Lausanne, Switzerland; Community Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland. Electronic address: jerome.favrod@chuv.ch.
authors.forename: J
authors.initials: J
authors.lastname: Favrod
authors.affiliation: La Source, School of Nursing Sciences, University of Applied Sciences of Western Switzerland, avenue Vinet 30, 1004 Lausanne, Switzerland; Community Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Rexhaj
authors.affiliation: Community Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Bardy
authors.affiliation: La Source, School of Nursing Sciences, University of Applied Sciences of Western Switzerland, avenue Vinet 30, 1004 Lausanne, Switzerland; Community Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Ferrari
authors.affiliation: HorizonSud, case postale 41, 1633 Marsens, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Hayoz
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center in Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Moritz
authors.affiliation: General Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Conus
authors.affiliation: Community Psychiatry Service, Department of psychiatry, University Hospital Center of Lausanne, site de Cery, 1008 Prilly, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Bonsack
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003702:Delusions / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents
keywords: Cognitive biases; Metacognitive training; Psychosis; Randomized study; Schizophrenia