title: Screening for lung cancer with low-dose computed tomography: a review of current status.
abstract: Screening using low-dose computed tomography (CT) represents an exciting new development in the struggle to improve outcomes for people with lung cancer. Randomised controlled evidence demonstrating a 20% relative lung cancer mortality benefit has led to endorsement of screening by several expert bodies in the US and funding by healthcare providers. Despite this pivotal result, many questions remain regarding technical and logistical aspects of screening, cost-effectiveness and generalizability to other settings. This review discusses the rationale behind screening, the results of on-going trials, potential harms of screening and current knowledge gaps.
authors.affiliation: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia; ; University of Queensland Thoracic Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia;
authors.forename: Henry M
authors.initials: HM
authors.lastname: Marshall
authors.forename: Rayleen V
authors.initials: RV
authors.lastname: Bowman
authors.forename: Ian A
authors.initials: IA
authors.lastname: Yang
authors.forename: Kwun M
authors.initials: KM
authors.lastname: Fong
authors.forename: Christine D
authors.initials: CD
authors.lastname: Berg
keywords: Lung neoplasms/mortality; early detection of cancer/methods; helical computed; mass screening tomography