title: [Endoplasmic reticulum stress response in osteogenesis].
abstract: Various cellular conditions such as synthesis of abundant proteins, expressions of mutant proteins and oxidative stress lead to accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen. This type of stress is called ER stress. The excessive ER stress causes cellular damages followed by apoptosis. When ER stress occurs, cells are activated ER stress response (unfolded protein response) to avoid cellular damages. Recently, it has been clear that ER stress response plays crucial roles not only in cell survival after ER stress but also in regulating various cellular functions and tissue formations. In particular, ER stress and ER stress response regulate protein quality control, secretory protein production, and smooth secretion of proteins in the cells such as osteoblasts which synthesize and secrete enormous matrix proteins.
authors.affiliation: Department of Biochemistry, Institute of Biomedical & Health Sciences, University of Hiroshima, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
authors.forename: Kazunori
authors.initials: K
authors.lastname: Imaizumi
mesh_terms: D051701:Activating Transcription Factor 4; D051702:Activating Transcription Factor 6; D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein; D059865:Endoplasmic Reticulum Stress / Q000235:genetics* / Q000502:physiology*; D004722:Endoribonucleases; D006801:Humans; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis / Q000235:genetics* / Q000502:physiology*; D017510:Protein Folding; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction / Q000502:physiology*; D019892:eIF-2 Kinase
chemical_list: C497109:ATF4 protein, human; C497111:ATF6 protein, human; D051702:Activating Transcription Factor 6; C485618:CREB3L1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D034521:Nuclear Matrix-Associated Proteins; D051701:Activating Transcription Factor 4; C403982:ERN2 protein, human; C460640:EIF2AK3 protein, human; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase; D004722:Endoribonucleases