title: Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy.
abstract: Multifunctional nanoparticles as theranostic tools hold great potential for its unique and efficient way to visualize the process of disease treatment. However, the toxicity of conventional fluorescent labels and difficulty of functionalization limit their widespread use. Recently, a number of amino-rich polymers have demonstrated high luminescent fluorescence but rarely showed potential for in vivo imaging due to their blue fluorescence. Here, a general route has been found to construct polymer-based multifunctional nanoparticles for combined imaging and drug delivering. The weak fluorescent polyethyleneimine (PEI) has been conjugated with hydrophobic polylactide as the amphiphilic PEI for construction of nanoparticles which showed bright and multicolor fluorescence with high drug loading capacity. The paclitaxel-loaded nanoparticles showed significant therapy effect in contrast to the free paclitaxel. Meanwhile, fluorescence imaging of the nanoparticles showed accumulation around tumor. These results demonstrate a new type of polymer-based multifunctional nanoparticles for imaging-guided drug delivery.
authors.affiliation: 1] Chinese Academy of Sciences Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology No.11, First North Road, Zhongguancun, Beijing 100190, P.R. China [2] College of Life Science and Bioengineering Beijing University of Technology No.100 Pingleyuan, Chaoyang District, Beijing 100124, P.R.China [3].
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Weipeng
authors.initials: W
authors.lastname: Cao
authors.forename: Shengliang
authors.initials: S
authors.lastname: Li
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.forename: Kelei
authors.initials: K
authors.lastname: Hu
authors.forename: Liming
authors.initials: L
authors.lastname: Hu
authors.forename: Yuanyu
authors.initials: Y
authors.lastname: Huang
authors.forename: Xueyun
authors.initials: X
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000379:methods; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D064593:Heterografts; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D051379:Mice; D057054:Molecular Imaging; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D061848:Optical Imaging / Q000379:methods; D017239:Paclitaxel / Q000008:administration & dosage; D011091:Polyesters / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D013501:Surface-Active Agents; C033616:poly(lactide); D011094:Polyethyleneimine; D017239:Paclitaxel