title: A non-Mendelian factor, [eta(+)], causes lethality of yeast omnipotent-suppressor strains.
abstract: Omnipotent suppressors cause translational ambiguity and have been associated with poor growth and inviability. We now report that a non-Mendelian element, [eta(+)], causes this inviability. In [eta(-)] strains the suppressors are not inviable. The [eta(+)] genetic element segregates to about 70% of the meiotic progeny, although almost all of the spores probably have the [eta(+)] phenotype for the first few divisions. Growth on 5 mM guanidine hydrochloride efficiently causes [eta(+)] strains to become [eta(-)]. The [eta(+)] factor has many similarities with the previously described [psi(+)] factor (Cox 1965, 1971). However, [eta(+)] and [psi(+)] differ in their patterns of inheritance, and by the fact that [psi(+)] affects ochre specific and not omnipotent suppressors, while the converse is true of [eta(+)].
authors.affiliation: Department of Biological Sciences, University of Illinois at Chicago, Box 4348, 60680, Chicago, Illinois, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Liebman
authors.forename: J A
authors.initials: JA
authors.lastname: All-Robyn