title: [Leber's hereditary optic neuropathy].
abstract: Lebers hereditary optic neuropathy (LHON) is a maternally inherited disease characterized by subacute severe visual loss in both eyes, which usually manifests in young adulthood. The disease has maternal inheritance due to mitochondrial DNA mutation. The final diagnosis is genetic. There is still no proven treatment, but there is significant progress in developments on the genetics of the disease to reach gene therapy. In this article we review the latest literature relevant to this disease.
authors.affiliation: Ophthalmology Department, HaEmek Medical Center, Afula, Israel. wasseem3@hotmail.com
authors.forename: Wasseem
authors.initials: W
authors.lastname: Hilo
authors.forename: Haneen
authors.initials: H
authors.lastname: Jabaly-Habib
authors.forename: Naftali
authors.initials: N
authors.lastname: Modi
authors.forename: Daniel
authors.initials: D
authors.lastname: Briscoe
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D009154:Mutation; D029242:Optic Atrophy, Hereditary, Leber / Q000235:genetics / Q000503:physiopathology*; D012720:Severity of Illness Index; D014786:Vision Disorders / Q000209:etiology*; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial