title: Novel controlled drug delivery system for multiple drugs based on electrospun nanofibers containing nanomicelles.
abstract: This research described a novel composite electrospun nanofibers, which were consisted of MPEG-b-PLA micelles, chitosan, and PEO, realizing controlled release of both hydrophobic and hydrophilic drugs. 5-FU and Cefradine used as model drugs were successfully loaded in the nanofibers. The in vitro studies showed there was a low initial burst release of 5-FU from micelles-loaded nanofibers, and the final release proportion was about 91.4% after continually releasing for 109 h. In vitro cytotoxicity studies revealed that 5-FU-loaded nanofibers restrained HepG-2 cells efficiently, and the cell viability was 45.9% after three days of cultivation in solutions containing micelles-loaded nanofibers with 21.6 μg 5-FU. All results suggested that micelles-loaded nanofibers with two kinds of drugs can be used as an effective controlled drug delivery vehicle and may have a bright future in cancer chemotherapy or clinical treatments.
authors.affiliation: a Department of Chemistry , Institute of Polymers, Nanchang University , 999 Xuefu Avenue, Nanchang 330031 , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Fangfa
authors.initials: F
authors.lastname: Zeng
authors.forename: Junchao
authors.initials: J
authors.lastname: Wei
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Yiwang
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002515:Cephradine / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; C492425:methoxy poly(ethylene glycol)-poly(lactide); D011092:Polyethylene Glycols; D002515:Cephradine; D005472:Fluorouracil