title: Diagnosis performance of high sensitivity troponin assay in out-of-hospital cardiac arrest patients.
abstract: OBJECTIVE
  Early identification of the cause of out-of-hospital cardiac arrest (OHCA) remains a challenge. Our aim was to determine whether high-sensitivity cardiac troponin T (HsTnT) was useful to diagnose a recent coronary artery occlusion as the cause of OHCA.
  
  
  METHODS
  Retrospective study including OHCA patients evaluated by systematic coronary angiogram at hospital admission. HsTnT was assessed at ICU admission. Predictive factors of a recent coronary occlusion were identified by logistic regression. Net reclassification improvement (NRI) was calculated to estimate the potential enhancement of prediction with HsTnT.
  
  
  RESULTS
  During the 5 year study period, 272 patients (median age 60 y, 76.5% men) were included, and a culprit coronary occlusion was found in 133 (48.9%). The optimum HsTnT cut-off to predict a recent coronary occlusion was 575 ng/l (sensitivity 65.4%, specificity 65.5%). In multivariate analysis, current smoking (OR 3.2 95%, 95%CI 1.62-6.33), time from collapse to BLS<3 min (OR 2.11, 95%CI 1.10-4.05), initial shockable rhythm (OR 5.29, 95%CI 2.06-13.62), ST-segment elevation (OR 2.44, 95%CI 1.18-5.03), post-resuscitation shock onset (OR 2.03, 95%CI 1.01-4.07) and HsTnT≥575 ng/l (OR 2.22, 95%CI 1.16-4.27) were associated with the presence of a recent coronary occlusion. Nevertheless, adding HsTnT to established risk factors of recent coronary occlusion identified above provided a non-significant NRI of -0.43%.
  
  
  CONCLUSIONS
  Admission HsTnT is increased after OHCA and is an independent factor of a recent coronary occlusion. However, HsTnT does not seem to be a strong enough diagnostic tool to select candidates for emergent coronary angiogram in OHCA survivors.
authors.affiliation: Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Universitaire Cochin Broca Hôtel-Dieu, Assistance Publique - Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Geri
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mongardon
authors.forename: Florence
authors.initials: F
authors.lastname: Dumas
authors.forename: Camille
authors.initials: C
authors.lastname: Chenevier-Gobeaux
authors.forename: Olivier
authors.initials: O
authors.lastname: Varenne
authors.forename: Xavier
authors.initials: X
authors.lastname: Jouven
authors.forename: Benoît
authors.initials: B
authors.lastname: Vivien
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mira
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Empana
authors.forename: Christian
authors.initials: C
authors.lastname: Spaulding
authors.forename: Alain
authors.initials: A
authors.lastname: Cariou
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D012042:Registries; D012189:Retrospective Studies; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: Acute coronary syndrome; Biomarker; Cardiac arrest; Cardiac arrest etiology; High-sensitivity troponin; Outcome