title: Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.
abstract: The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK. Electronic address: amewu@liverpool.ac.uk.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Amewu
authors.forename: James
authors.initials: J
authors.lastname: Chadwick
authors.forename: Afthab
authors.initials: A
authors.lastname: Hussain
authors.forename: Somnath
authors.initials: S
authors.lastname: Panda
authors.forename: Rinki
authors.initials: R
authors.lastname: Rinki
authors.forename: Omar
authors.initials: O
authors.lastname: Janneh
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Ward
authors.forename: Candel
authors.initials: C
authors.lastname: Miguel
authors.forename: Hollie
authors.initials: H
authors.lastname: Burrell-Saward
authors.forename: Livia
authors.initials: L
authors.lastname: Vivas
authors.forename: Paul M
authors.initials: PM
authors.lastname: O'Neill
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D019281:Dimerization; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects; D045568:Tetraoxanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D045568:Tetraoxanes; D053148:Caspase 3
keywords: Apoptosis; Leukaemia; Malaria