title: Antiviral-resistant fulminant herpes hepatitis in pregnancy.
abstract: Fulminant herpes hepatitis with disseminated extrahepatic involvement in pregnancy is rare and carries a high mortality risk. Although acyclovir remains standard first-line therapy, effective management of acyclovir-resistant disseminated herpes simplex virus (HSV) in pregnancy remains elusive. We present a case of disseminated HSV resistant to both acyclovir and foscarnet, the first double-agent resistant case in pregnancy reported in the literature to date. In this case, therapeutic delivery was the ultimate treatment resulting in full recovery.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Herrera
authors.forename: Kacey Y
authors.initials: KY
authors.lastname: Eichelberger
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Chescheir
keywords: disseminated herpes; fulminant herpes; herpes hepatitis; pregnancy herpes