title: Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate.
abstract: OBJECTIVE
  The aim of this work was to develop and characterise S-SEDDS containing fenofibrate (FF) for dissolution enhancement.
  
  
  METHODS
  The self-emulsifying pre-concentrate was prepared by using different proportion of Labrafac WL1349 as oily phase, Cremophor EL as surfactants and Gelucire 44/14 as co-surfactant. The prepared pre-concentrate was solidified with PEG 6000. For comparison, formulations containing TPGS as surfactant and solidifier were prepared and studied.
  
  
  RESULTS
  The cremophor/PEG and TPGS based S-SEDDS formulations containing 10 and 15% w/w FF when dispersed in water, formed nanoemulsion with a size range of 150-200 nm. FF was present in the crystalline state in the formulations. The formulations containing 10% w/w FF showed 90-100% dissolution in 60 min whereas the untreated FF showed only 2-4% dissolution.
  
  
  CONCLUSIONS
  A novel S-SEDDS was developed for FF using cremophor/PEG and TPGS. The dissolution of FF was enhanced by approximately 20-fold in SGF pH 1.2.
authors.affiliation: Institute of Chemical and Engineering Sciences , Jurong Island , Singapore .
authors.forename: Parijat
authors.initials: P
authors.lastname: Kanaujia
authors.forename: Wai Kiong
authors.initials: WK
authors.lastname: Ng
authors.forename: Reginald B H
authors.initials: RB
authors.lastname: Tan
mesh_terms: D016503:Drug Delivery Systems; D004655:Emulsions; D011345:Fenofibrate / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000737:chemistry*; D012995:Solubility; D014280:Triglycerides / Q000737:chemistry*
chemical_list: D004655:Emulsions; D000960:Hypolipidemic Agents; D014280:Triglycerides; C542236:labrafac WL 1349; C000515:cremophor EL; D005990:Glycerol; D011345:Fenofibrate