title: The effects of low vitamin D on coronary artery disease.
abstract: OBJECTIVE
  Coronary Artery Disease (CAD) remains a major cause of morbidity and mortality in the world. Low vitamin D status has been shown to be associated with increased risk of developing cardiovascular disease, hypertension and obesity. We planned to research the association between low vitamin D status and the severity of CAD.
  
  
  METHODS
  A total of 348 consecutive patients undergoing coronary angiography for evaluation of CAD were included in this study. 25-Hydroxyvitamin D [25(OH)D] was measured by chemiluminescence assay. CAD severity was assessed by using the SYNTAX scores. The data presented are the mean levels/values and standard deviation.
  
  
  RESULTS
  The serum 25(OH)D level of CAD patients was 18.2 ± 10.6 ng/ml. The SYNTAX scores were 27.8 ± 8.5. In a multivariate linear regression analysis (adjusted for age, high-sensitivity C-reactive protein, SYNTAX score, parathyroid hormone, body mass index, haemoglobin and creatinine), the serum 25(OH)D level showed a negative correlation with SYNTAX score and high-sensitivity C-reactive protein (hsCRP) level. Logistic regression analysis identified 25(OH)D as an independent factor related to high SYNTAX scores. Patients whose vitamin D levels were in the lowest 25(OH)D category (<20 ng/ml) were more often in the high SYNTAX scores group, with their incidence about two-fold higher than those in the highest 25(OH)D category (>30 ng/ml).
  
  
  CONCLUSIONS
  Low vitamin D is associated with the severity of coronary artery stenosis.
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, China. Electronic address: 301chenwr@sina.com.
authors.forename: Wei Ren
authors.initials: WR
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Lujiang People's Hospital, Anhui Province, China.
authors.forename: Yong An
authors.initials: YA
authors.lastname: Qian
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, China. Electronic address: cyundai@medmail.com.cn.
authors.forename: Yun Dai
authors.initials: YD
authors.lastname: Chen
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Da Wei
authors.initials: DW
authors.lastname: Yin
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Hong Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of South-building Cardiology, PLA General Hospital at Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sha
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology; D023921:Coronary Stenosis / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Coronary angiography; Coronary artery disease; Inflammation; SYNTAX scores; Vitamin D