title: Detection of S100B in maternal blood before and after fetal death.
abstract: BACKGROUND
  S100B is a brain damage biomarker. When measured immediately after birth, it reflects neonatal brain damage following asphyxia. In this study, we used feticide as a novel model of fetal brain damage. We examined whether such damage is reflected by a rise in S100B in maternal blood before delivery.
  
  
  METHODS
  Eight pregnant women were recruited between January and July 2012. Maternal blood samples were drawn before and after feticide at predetermined time points (0, 15, 30, 60, 120, and 240 min). S100B, lactate dehydrogenase, creatine kinase, and creatinine concentrations were measured by standard human ELISA and chemical analyzer.
  
  
  RESULTS
  No significant difference was noted between S100B levels before and after feticide, neither in non-specific cell death markers (lactate dehydrogenase and creatine kinase), which remained within normal range. S100B ranged between 0.015-0.04 µg/L through all the predetermined time points.
  
  
  CONCLUSIONS
  No statistically significant differences were demonstrated in S100B levels before and after feticide.
authors.affiliation: Department of Obstetrics & Gynecology, Soroka University Medical Center, Beer Sheva, Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Beharier
authors.forename: Eden
authors.initials: E
authors.lastname: Shusterman
authors.forename: Tamar
authors.initials: T
authors.lastname: Eshcoli
authors.forename: Irit
authors.initials: I
authors.lastname: Szaingurten-Solodkin
authors.forename: Barak
authors.initials: B
authors.lastname: Aricha-Tamir
authors.forename: Adi Y
authors.initials: AY
authors.lastname: Weintraub
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
authors.forename: Gershon
authors.initials: G
authors.lastname: Holcberg
authors.forename: Reli
authors.initials: R
authors.lastname: Hershkovitz
mesh_terms: D000013:Congenital Abnormalities; D005260:Female; D005313:Fetal Death / Q000097:blood* / Q000139:chemically induced; D005865:Gestational Age; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D011189:Potassium Chloride / Q000008:administration & dosage; D011247:Pregnancy; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D011189:Potassium Chloride