title: Association between the body mass index and chronic kidney disease in men and women. A population-based study from Israel.
abstract: BACKGROUND
  Any association between the body mass index (BMI) and chronic kidney disease (CKD) has so far proved inconclusive. Most studies have estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) equation. This has recently been replaced by the more accurate Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
  
  
  METHODS
  In a cross-sectional study, data from a screening centre in Israel, n = 21880 (32% women) were used to assess the prevalence of CKD defined as eGFR < 60 mL/min/1.73 m(2) in relation to BMI categories. The CKD-EPI equation was used to assess the eGFR.
  
  
  RESULTS
  CKD was found in 167 men and 45 women. Subjects with a BMI of 25-29.9 kg/m(2), compared with those with a BMI of <25 kg/m(2), had an odds ratio (OR; 95% confidence intervals) for CKD of 1.8 (1.2-2.7) and 3.4 (1.5-7.7) for men and women, respectively. Subjects with a BMI of 30-35 kg/m(2) had an OR of 2.5 (1.6-4.0) and 4.5 (1.7-11.7) for men and women, respectively. In comparable data, for subjects with a BMI > 35 kg/m(2) the OR was 2.7 (1.3-5.5) and 15.4 (6.4-36.7) for men and women, respectively. After multivariate adjustment for age, hypertension and diabetes mellitus, no association was found in men yet it persisted for women. This correlation in women, between the BMI and CKD, was attributed to the subcategory of severely obese women with a BMI of >35 kg/m(2).
  
  
  CONCLUSIONS
  Our study is the first to suggest that morbid obesity may be an independent factor related to CKD in women.
authors.affiliation: Department of Medicine F-Recanati,Rabin Medical Center, Campus Beilinson, Petah Tiqwa, Israel.
authors.forename: Eytan
authors.initials: E
authors.lastname: Cohen
authors.forename: Abigail
authors.initials: A
authors.lastname: Fraser
authors.forename: Elad
authors.initials: E
authors.lastname: Goldberg
authors.forename: Gai
authors.initials: G
authors.lastname: Milo
authors.forename: Moshe
authors.initials: M
authors.lastname: Garty
authors.forename: Ilan
authors.initials: I
authors.lastname: Krause
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000503:physiopathology; D016017:Odds Ratio; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000503:physiopathology; D012737:Sex Factors; D055815:Young Adult
keywords: CKD-EPI equation; body mass index; chronic kidney disease; gender