title: Effect of creatine monohydrate supplementation on various hematological and serum biochemical parameters of male albino mice following neonatal hypoxia-ischemia encephalopathy.
abstract: BACKGROUND
  Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10.
  
  
  METHODS
  66 Blood samples (2% creatine monohydrate supplemented (N = 34) and unsupplemented (N = 32)) were analyzed for various hematological (blood glucose, packed cell volume, total WBC count, total RBC count) and serum biochemical parameters (cholesterol, AST, ALT, HDL, LDL, total protein, triglycerides).
  
  
  RESULTS
  ALT had higher concentrations in mice feeding on normal diet for 8 (P > 0.01) and 12 weeks (P > 0.01) following asphyxia and in 12 weeks treatment without asphyxia (P = 0.006) when compared with the creatine supplemented mice. LDL (P = 0.011) and cholesterol (P > 0.01) had higher concentrations in mice on normal diet for 12 weeks following hypoxia ischemia. Cholesterol (P > 0.01) in 12 and glucose (P = 0.006) in 15 week treatment group had significantly lower concentrations in creatine supplemented male albino mice when compared with untreated group following hxpoic-ischemic insult.
  
  
  CONCLUSIONS
  We concluded that creatine supplementation following hypoxic ischemic insult helps in maintain the normal blood chemistry.
authors.affiliation: Zoology Division, Department of Zoology, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Iqbal
authors.forename: Nabia
authors.initials: N
authors.lastname: Nazir
authors.forename: Quratulane
authors.initials: Q
authors.lastname: Gillani
authors.forename: Atif
authors.initials: A
authors.lastname: Akbar
authors.forename: Furhan
authors.initials: F
authors.lastname: Iqbal
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001772:Blood Cell Count; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D003401:Creatine / Q000494:pharmacology*; D002534:Hypoxia, Brain / Q000097:blood* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D014280:Triglycerides; D002784:Cholesterol; D003401:Creatine