title: Quantification of abdominal aortic aneurysm wall enhancement with dynamic contrast-enhanced MRI: feasibility, reproducibility, and initial experience.
abstract: OBJECTIVE
  To investigate the feasibility and reproducibility of dynamic contrast-enhanced MRI (DCE-MRI) to quantify abdominal aortic aneurysm (AAA) vessel wall enhancement dynamics which may reflect the amount of wall microvasculature. AAA vessel wall microvasculature has been linked with aneurysm progression and rupture.
  
  
  METHODS
  Thirty patients with AAA underwent DCE-MRI at 1.5 Tesla. Enhancement dynamics of the aneurysm wall were quantified in regions-of-interest (ROIs) in the vessel wall by calculating the transfer constant (K(trans) ) using pharmacokinetic modeling and the area-under-gadolinium-curve (AUC). To assess reproducibility, 10 patients were imaged twice on different occasions. ROIs were drawn by two independent observers. The intraclass correlation coefficients (ICC) and coefficients of variation (CV) were determined to investigate intra-, interobserver, and interscan variability.
  
  
  RESULTS
  Twenty-eight analyzable MR examinations were included for pharmacokinetic analysis after excluding two examinations due to severe motion artifacts. Intra-, interobserver, and interscan variability for K(trans) were small (all ICC > 0.90, CV < 14%) as well as for AUC measurements (all ICC > 0.88, CV < 23%).
  
  
  CONCLUSIONS
  Quantitative analysis of AAA vessel wall enhancement dynamics with DCE-MRI is feasible and reproducible.
authors.affiliation: Department of General Surgery, Maastricht University Medical Center (MUMC), Maastricht, The Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: V Lai
authors.initials: VL
authors.lastname: Nguyen
authors.forename: Walter H
authors.initials: WH
authors.lastname: Backes
authors.forename: M Eline
authors.initials: ME
authors.lastname: Kooi
authors.forename: Mirthe C J
authors.initials: MC
authors.lastname: Wishaupt
authors.forename: Femke A M V I
authors.initials: FA
authors.lastname: Hellenthal
authors.forename: E Marielle H
authors.initials: EM
authors.lastname: Bosboom
authors.forename: Rob J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: Geert Willem H
authors.initials: GW
authors.lastname: Schurink
authors.forename: Tim
authors.initials: T
authors.lastname: Leiner
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology*; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis*; D019540:Area Under Curve; D003287:Contrast Media / Q000493:pharmacokinetics; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055806:Microvessels; D015588:Observer Variation; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
keywords: abdominal aortic aneurysm; dynamic contrast-enhanced MRI; microvascularization; vessel wall imaging