title: Association of regional body fat with metabolic risks in Chinese women.
abstract: OBJECTIVE
  To investigate the association of regional fat depots with metabolic risk factors in Chinese women.
  
  
  METHODS
  Total and regional fat depots including android fat and gynoid fat were measured by dual-energy X-ray absorptiometry. Central fat distribution was defined as android:gynoid fat ratio. Metabolic risk factors were defined as elevated TAG, reduced HDL-cholesterol, elevated blood pressure and elevated fasting plasma glucose. Logistic regression analyses were performed to examine the associations of regional fat depots with metabolic risk factors. The odds ratios of metabolic risks were further calculated according to tertiles of android fat and gynoid fat.
  
  
  METHODS
  Participants were recruited from a community-based cross-sectional study. Face-to-face questionnaires, anthropometric and dual-energy X-ray absorptiometry measures were conducted.
  
  
  METHODS
  Chinese women (n 609) aged 18-79 years.
  
  
  RESULTS
  Android fat and android:gynoid fat ratio were associated with significantly increased odds (OR = 1·4-3·7; P < 0·01) for almost all risk factors, whereas gynoid fat was independently associated with significantly decreased odds (OR = 0·3-0·6; P < 0·01). The inverse associations of gynoid fat with metabolic risk factors remained after adjusting for android fat. Even if their android fat level was in high, women in the highest tertile of gynoid fat had lower odds of having at least two metabolic risk factors compared with women in the lowest gynoid fat tertile (P for trend < 0·01).
  
  
  CONCLUSIONS
  There were opposite associations of android and gynoid fat with metabolic risks in Chinese women. Gynoid fat rather than android fat might be a more important inclusion in metabolic disease risk evaluation in female Asians.
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Fu
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Song
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 3Department of Epidemiology and Biostatistics,Arnold School of Public Health,University of South Carolina,Columbia,SC,USA.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Ma
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Jiao
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: 1Obesity and Body Composition Research Center,Chronic Disease Research Institute,Zhejiang University,Hangzhou,People's Republic of China.
authors.forename: Shankuan
authors.initials: S
authors.lastname: Zhu
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000208:ethnology; D000293:Adolescent; D000328:Adult; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology / Q000503:physiopathology*; D050177:Overweight / Q000208:ethnology / Q000503:physiopathology*; D010388:Pelvis; D015995:Prevalence; D012307:Risk Factors; D014472:Umbilicus; D051598:Whole Body Imaging; D055815:Young Adult