title: A new medical treatment with botulinum toxin in persistent genital arousal disorder: successful treatment of two cases.
abstract: Persistent genital arousal disorder is described in a spontaneous, persistent, and uncontrollable genital arousal in women, with or without orgasm or genital engorgement, unrelated to any feelings of sexual desire. This study aimed to argue that application of Botulinum toxin in the periclitoral region in order to block the dorsal nerve of the clitoris might decrease symptoms of persistent genital arousal disorder. The authors presented 2 cases, in which application of Botulinum toxin resulted in improvement of the symptoms of persistent genital arousal disorder. Botulinum toxin type A treatment protocol is seen as a promising application for the persistent genital arousal disorder. However, further controlled studies in large samples are needed.
authors.affiliation: a Adana Numune Education and Research Hospital , Department of Obstetrics and Gynecology , Adana , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Nazik
authors.forename: Murat
authors.initials: M
authors.lastname: Api
authors.forename: Hakan
authors.initials: H
authors.lastname: Aytan
authors.forename: Raziye
authors.initials: R
authors.lastname: Narin
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A; D002987:Clitoris / Q000294:innervation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D009407:Nerve Block / Q000379:methods*; D009948:Orgasm / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*
chemical_list: D019274:Botulinum Toxins, Type A