title: The tumor necrosis factor-alpha-induced protein 8 family in immune homeostasis and inflammatory cancer diseases.
abstract: Within the immune system homeostasis is maintained by a myriad of mechanisms that include the regulation of immune cell activation and programmed cell death. The breakdown of immune homeostasis may lead to fatal inflammatory diseases. We set out to identify genes of tumor necrosis factor-alpha-induced protein 8 (TNFAIP8) family that has a functional role in the process of immune homeostasis. Tumor necrosis factor-alpha-induced protein 8 (TNFAIP8), which functions as an oncogenic molecule, is also associated with enhanced cell survival and inhibition of apoptosis. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) governs immune homeostasis in both the innate and adaptive immune system and prevents hyper-responsiveness by negatively regulating signaling via T cell receptors and Toll-like receptors (TLRs). There also exist two highly homologous but uncharacterized proteins, TIPE1 and TIPE3. This review is an attempt to provide a summary of TNFAIP8 family associated with immune homeostasis and inflammatory cancer diseases.
authors.affiliation: Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Luan
authors.forename: Y M
authors.initials: YM
authors.lastname: Yao
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Sheng
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D009369:Neoplasms / Q000209:etiology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D047908:Intracellular Signaling Peptides and Proteins; C404190:TNFAIP8 protein, human; C552057:TNFAIP8L2 protein, human