title: Noninvasive double confirmation of cocaine abuse.
abstract: A double confirmation procedure, based on the combined application of Ion Mobility Spectrometry (IMS) and Infrared Spectroscopy (IR), has been developed for the noninvasive unambiguous identification of cocaine consume. The use of nasal mucus as a biological specimen for cocaine abuse confirmation has been proposed as an alternative to the use of blood and urine due to its noninvasive character and the presence of the parent compound instead of its metabolites. Sampling conditions, interferences caused by cutting agents and other substances, and limits of identification (LOI) and confirmation (LOC) have been deeply evaluated. The procedure combines the high sensitivity of the IMS to identify positive samples with the high selectivity of the IR procedure to confirm positive results. Thus, the proposed two tier method has been applied to the detection and identification of cocaine in the nasal mucus of different individuals, consumers, and nonconsumers, providing results comparable with those obtained by a reference procedure.
authors.affiliation: Department of Analytical Chemistry, Research Building, University of Valencia , 50th Dr. Moliner St., E-46100 Burjassot, Valencia, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Armenta
authors.forename: Miguel
authors.initials: M
authors.lastname: de la Guardia
authors.forename: Manel
authors.initials: M
authors.lastname: Alcalà
authors.forename: Marcelo
authors.initials: M
authors.lastname: Blanco
mesh_terms: D000328:Adult; D003042:Cocaine / Q000032:analysis*; D019970:Cocaine-Related Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009093:Mucus / Q000737:chemistry*; D009297:Nasal Mucosa / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods* / Q000592:standards; D015813:Substance Abuse Detection / Q000379:methods* / Q000592:standards
chemical_list: D003042:Cocaine