title: Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
abstract: Glioma stem-like cells have been demonstrated to have highly invasive activity, which is the major cause of glioma recurrence after therapy. Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored. In the current study, we aimed to explore the role of leptin during glioma stem-like cells invasion as well as the signaling pathway. We found that glioma stem-like cells exhibited high invasive potential, especially in the presence of leptin, Ob-R coexpressed with CD133 in glioma stem-like cells was showed to be responsible for leptin mediated invasion of glioma stem-like cells. Our results indicated that leptin served as a key intermediary linking the accumulation of excess adipokine to the invasion of glioma stem-like cells, which may be a novel therapeutic target for suppressing tumor invasion and recurrence.
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Laixing
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Yue
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Electronic address: liujianmin2011@hotmail.com.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000494:pharmacology*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D009930:Organic Chemicals / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D002867:Chromones; D004791:Enzyme Inhibitors; D006023:Glycoproteins; D020738:Leptin; D009025:Morpholines; D009930:Organic Chemicals; C466090:PD 98058; C000606023:PROM1 protein, human; D010455:Peptides; D034741:RNA, Small Interfering; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D020780:Matrix Metalloproteinase 9
keywords: Glioma stem-like cells; Invasion; Leptin; Leptin receptor