title: [Potentials for the conservative therapy in the complex treatment of varicocele in adolescents].
abstract: The article presents the results of the evaluation of the influence of varicocele on the reproductive system of adolescents from the perspective of involvement of periprostatic venous plexus and prostatovesicular complex in the pathological process. The study involved 90 adolescents 16-18 years old with left varicocele and disturbances in ejaculate parameters, of which 60 had pelvic congestion. Patients and control group received a comprehensive treatment, including preoperative trophic and flebotonic therapy, laparoscopic surgical clipping of the internal spermatic vein and post-operative rehabilitation. Patients of the study group along with this treatment received prostatotropic drug Vitaprost. According to the results of study, it was found that in patients with varicocele, attention should pay to the status of the venous outflow from the pelvic organs, which leads to the pelvic congestion and causes degenerative changes in the prostate in half of cases, which in turn negatively affects the spermogram parameters and increases the risk of subfertility. The use of prostatotropic drugs in the treatment of patients suffering from varicoceles with pelvic congestion is appropriate and pathogenetically justified, as it promotes a more rapid restoration of the structure and function of the prostate.
authors.forename: I S
authors.initials: IS
authors.lastname: Popov
authors.forename: A I
authors.initials: AI
authors.lastname: Neĭmark
authors.forename: A V
authors.initials: AV
authors.lastname: Gazamatov
mesh_terms: D000285:Administration, Rectal; D000293:Adolescent; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D007290:Inosine Diphosphate / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D011300:Preoperative Care; D013488:Suppositories; D016896:Treatment Outcome; D014646:Varicocele / Q000188:drug therapy* / Q000601:surgery*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D006896:Hydroxyethylrutoside; D010455:Peptides; D013488:Suppositories; D014662:Vasoconstrictor Agents; C524164:Vitaprost; D014801:Vitamin A; D014810:Vitamin E; C048974:vitamin A, vitamin E drug combination; C005865:troxerutin; D007290:Inosine Diphosphate