title: Phosphodiesterase 5 as target for adipose tissue disorders.
abstract: BACKGROUND
  Adipose tissue as an endocrine organ is responsible for the release of multiple cytokines, which have the most diverse metabolic functions. Therefore, it is extremely important to preserve its physiological health in order to avoid local and systemic disorders. Experiments available in literature show the importance of the nitric oxide (NO)/guanosine 3'5' cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway in adipocyte biology. Phosphodiesterase 5 (PDE5) is an enzyme responsible for cGMP inactivation, and the use of its inhibitors can be an alternative in the search of a more balanced adipose tissue.
  
  
  OBJECTIVE
  This review aims to describe the PDE5 role and the possibility of using PDE5 inhibitors in adipocyte physiology derangements and their consequences.
  
  
  METHODS
  Studies published in the last 10years that related PDE5 and its inhibitors to adipose tissue were raised in major databases.
  
  
  RESULTS
  PDE5 is present in adipocyte, and PDE5 inhibitors can promote adipogenesis, interfere with adipokines secretion, decrease inflammatory markers expression, and increase the thermogenic potential of white adipose tissue.
  
  
  CONCLUSIONS
  PDE5 plays an important role in adipocyte physiology and the use of its inhibitors may prove a useful tool to combat adipose tissue disorders and its highest expression, metabolic syndrome.
authors.affiliation: Federal University of Santa Catarina, Brazil. Electronic address: gcolomboufsc@gmail.com.
authors.forename: Giovani
authors.initials: G
authors.lastname: Colombo
authors.forename: Maria Daniela H Périco
authors.initials: MD
authors.lastname: Colombo
authors.forename: Leonardo De Lucca
authors.initials: Lde L
authors.lastname: Schiavon
authors.forename: Armando José
authors.initials: AJ
authors.lastname: d'Acampora
mesh_terms: D017667:Adipocytes; D054392:Adipokines; D000273:Adipose Tissue / Q000502:physiology / Q000503:physiopathology; D000818:Animals; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D006801:Humans; D051379:Mice; D009569:Nitric Oxide; D058986:Phosphodiesterase 5 Inhibitors; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D058986:Phosphodiesterase 5 Inhibitors; D009569:Nitric Oxide; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5
keywords: Adipocyte; Adipogenesis; Nitric oxide; Phosphodiesterase 5; Phosphodiesterase 5 inhibitor; White adipose tissue