title: Onset and duration period of pulpal anesthesia of articaine and lidocaine in inferior alveolar nerve block.
abstract: The purpose of this prospective, randomized, double blind study was to compare the onset and duration periods of pulpal anesthesia using 2% lidocaine with 1:100,000 epinephrine, 4% articaine with 1:100,000 epinephrine and 4% articaine with 1:200,000 epinephrine in inferior alveolar nerve block (IANB). Thirty subjects received 1.8 mL of each of the three local anesthetic solutions in IANB. Onset and duration periods of pulpal anesthesia were determined using electric pulp stimulation. The mean time of onset of pulpal anesthesia was 8.7, 7.4 and 7.7 min and the mean duration of pulpal anesthesia was 61.8, 106.6 and 88.0 min for 2% lidocaine with 1:100,000 epinephrine, 4% articaine with 1:100,000 epinephrine and 4% articaine with 1:200,000 epinephrine, respectively. For onset, there was only a significant difference between 2% lidocaine with 1:100,000 epinephrine and 4% articaine with 1:100,000 epinephrine (p=0.037). For duration, there was significant difference for all the local anesthetic solutions (p≤0.05). In conclusion, 4% articaine with 1:100,000 epinephrine exhibited faster onset and also had longest duration of pulpal anesthesia in IANB.
authors.affiliation: Department of Stomatology, School of Dentistry, USP - University of São Paulo, São PauloSP, Brazil.
authors.forename: Isabel Peixoto
authors.initials: IP
authors.lastname: Tortamano
authors.forename: Marcelo
authors.initials: M
authors.lastname: Siviero
authors.forename: Sara
authors.initials: S
authors.lastname: Lee
authors.forename: Roberta Moura
authors.initials: RM
authors.lastname: Sampaio
authors.forename: Jose Leonardo
authors.initials: JL
authors.lastname: Simone
authors.forename: Rodney Garcia
authors.initials: RG
authors.lastname: Rocha
mesh_terms: D000766:Anesthesia, Dental; D002355:Carticaine / Q000008:administration & dosage*; D003782:Dental Pulp; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D009407:Nerve Block / Q000379:methods*
chemical_list: D008012:Lidocaine; D002355:Carticaine