title: Clinical rehabilitation guidelines for matrix-induced autologous chondrocyte implantation on the tibiofemoral joint.
abstract: Autologous chondrocyte implantation (ACI) has become an established technique for the repair of full-thickness chondral defects in the knee. Matrix-induced ACI (MACI) is the third and current generation of this surgical technique, and, while postoperative rehabilitation following MACI aims to restore normal function in each patient as quickly as possible by facilitating a healing response without overloading the repair site, current published guidelines appear conservative, varied, potentially outdated, and often based on earlier ACI surgical techniques. This article reviews the existing evidence-based literature pertaining to cell loading and postoperative rehabilitation following generations of ACI. Based on this information, in combination with the technical benefits provided by third-generation MACI in comparison to its surgical predecessors, we present a rehabilitation protocol for patients undergoing MACI in the tibiofemoral joint that has now been implemented for several years by our institution in patients with MACI, with good clinical outcomes.
authors.affiliation: School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Australia.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Edwards
authors.forename: Timothy
authors.initials: T
authors.lastname: Ackland
authors.forename: Jay R
authors.initials: JR
authors.lastname: Ebert
mesh_terms: D002357:Cartilage Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D017690:Cell Transplantation / Q000534:rehabilitation*; D019902:Chondrocytes / Q000637:transplantation*; D002985:Clinical Protocols; D006801:Humans; D007719:Knee Joint; D014182:Transplantation, Autologous