title: Are anti-vitamin K drugs contraindicated with cetuximab during head-and-neck cancer concomitant radiotherapy?
abstract: Two cases of severe skin reactions to cetuximab and concomitant radiation therapy are reported in patients treated for locally advanced head-and-neck squamous cell carcinoma and concurrently treated with an antivitamin K drug for cardiovascular diseases. The role of vitamin K in the epidermal growth factor/epidermal growth factor receptor pathway is discussed. A plea for a specific registry is entered.
authors.affiliation: Department of Medical Oncology & Haematology, CHU de Charleroi, Hospital André Vésale, Montigny-le-Tilleul, Belgium. dany.brohee@chu-charleroi.be
authors.forename: D
authors.initials: D
authors.lastname: Brohée
authors.forename: A R
authors.initials: AR
authors.lastname: Henry
authors.forename: P
authors.initials: P
authors.lastname: Castadot
mesh_terms: D015110:4-Hydroxycoumarins; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D000068818:Cetuximab; D003131:Combined Modality Therapy; D000075202:Contraindications; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D007192:Indenes; D008297:Male; D008875:Middle Aged; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D015110:4-Hydroxycoumarins; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D007192:Indenes; C011664:antivitamins K; D014812:Vitamin K; D000068818:Cetuximab