title: Perineural infiltrates in Pseudomonas keratitis.
abstract: We describe 2 cases of contact lens-related microbial keratitis caused by infection with Pseudomonas aeruginosa in which perineural infiltrates were observed at presentation. In both cases, examination by confocal microscopy was negative for Acanthamoeba cysts but bacterial cultures and microscopy of corneal scrapings were positive for P aeruginosa. Both cases responded rapidly to treatment with topical levofloxacin with no significant long-term sequelae. These observations indicate that perineural infiltrates may occur in Pseudomonas keratitis without underlying Acanthamoeba infection and are, therefore, not pathognomonic of Acanthamoeba infection.
authors.affiliation: From Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: s.robbie@ucl.ac.uk.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Robbie
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Vega
authors.forename: Naing L
authors.initials: NL
authors.lastname: Tint
authors.forename: Scott
authors.initials: S
authors.lastname: Hau
authors.forename: Bruce
authors.initials: B
authors.lastname: Allan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003263:Contact Lenses, Hydrophilic / Q000382:microbiology; D003315:Cornea / Q000294:innervation*; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D064704:Levofloxacin / Q000627:therapeutic use; D018613:Microscopy, Confocal; D009882:Ophthalmic Nerve / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin