title: An adhesive (19)F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment.
abstract: We report a new strategy for designing a signal off-to-on-type (19)F MRI chemical probe that operates in biological environments. The present strategy is based on the control of adherence of a (19)F MRI chemical probe to certain blood proteins, accompanied by a change in transverse relaxation time of (19)F nuclei.
authors.affiliation: INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, Japan. ssando@ifrc.kyushu-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Doura
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Hata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonaka
authors.forename: Fuminori
authors.initials: F
authors.lastname: Sugihara
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sando
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015374:Biosensing Techniques; D004983:Ethanolamines / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D006997:Hypochlorous Acid / Q000032:analysis; D008279:Magnetic Resonance Imaging; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism; D014270:Trifluoroethanol / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D004983:Ethanolamines; D005456:Fluorescent Dyes; D012709:Serum Albumin; D005461:Fluorine; D006997:Hypochlorous Acid; D014270:Trifluoroethanol