title: Hereditary angioedema in women: specific challenges.
abstract: Women with hereditary angioedema (HAE) present with more frequent and more severe attacks than men. The disease is often affected by estrogenic status. Estrogens increase kininogenase activities. Deliveries seem to be safe but it is advised to have C1 inhibitor (C1Inh) concentrate in the delivery room; in case of worsening during the pregnancy, it is recommended to use short-term prophylaxis with C1Inh concentrate. Women often badly tolerate attenuated androgen: 30% of women have weight gain, 30% irregular menstruations, and 6% virilization. Acid tranexamic and progestins are preferred for long-term prophylaxis for women with HAE.
authors.affiliation: National Reference Centre for Angioedema (CREAK), Internal Medicine Department, Grenoble University Hospital, Joseph Fourier Grenoble 1 University, Cedex 09, Grenoble 38043, France. Electronic address: lbouillet@chu-grenoble.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Bouillet
authors.forename: Anne
authors.initials: A
authors.lastname: Gompel
mesh_terms: D000728:Androgens / Q000009:adverse effects / Q000627:therapeutic use; D054179:Angioedemas, Hereditary / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D001943:Breast Neoplasms / Q000150:complications; D003267:Contraception; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008593:Menopause; D010641:Phenotype; D011247:Pregnancy; D012737:Sex Factors
chemical_list: D000728:Androgens
keywords: Estrogen; Female; Hereditary angioedema; Progestin