title: Effect of risedronate on speed of sound in postmenopausal women with osteoporosis.
abstract: OBJECTIVE
  To examine the effects of treatment with risedronate for 1 year on speed of sound (SOS) of the calcaneus and bone turnover markers in postmenopausal women with osteoporosis.
  
  
  METHODS
  Thirty-eight postmenopausal women with osteoporosis who had been treated with risedronate for > 1 year were enrolled in the study. The SOS and bone turnover markers were monitored during treatment with risedronate for 1 year.
  
  
  RESULTS
  The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase were significantly decreased at 3 mo (-34.7%) and 12 mo (-21.2%), respectively, compared with the baseline values. The SOS increased modestly, but significantly by 0.65% at 12 mo compared with the baseline value. Treatment with risedronate elicited an increase in the SOS of the calcaneus exceeding the coefficient of variation in vivo (0.27%).
  
  
  CONCLUSIONS
  The present study confirmed that risedronate suppressed bone turnover and elicited a clinically significant increase in the SOS of the calcaneus in postmenopausal women with osteoporosis.
authors.affiliation: Jun Iwamoto, Hideo Matsumoto, Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Iwamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sato
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
keywords: Bone turnover; Postmenopausal women; Quantitative ultrasound; Risedronate; Speed of sound