title: Exacerbation phenotyping in chronic obstructive pulmonary disease.
abstract: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are crucial events but causes remain poorly defined. A method to clinically 'phenotype' AECOPD have been proposed, and 52 hospitalized chronic obstructive pulmonary disease exacerbations according to underlying aetiology have now been prospectively phenotyped. Multiple exacerbation phenotypes were identified. A subpopulation coinfected with virus and bacteria had a significantly longer length of hospital stay, and this pilot study indicates that exacerbation phenotyping may be advantageous.
authors.affiliation: Monash Lung and Sleep, Monash Medical Centre, Melbourne, Victoria, Australia.
authors.forename: Martin
authors.initials: M
authors.lastname: MacDonald
authors.forename: Tony
authors.initials: T
authors.lastname: Korman
authors.forename: Paul
authors.initials: P
authors.lastname: King
authors.forename: Kais
authors.initials: K
authors.lastname: Hamza
authors.forename: Philip
authors.initials: P
authors.lastname: Bardin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060085:Coinfection / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D015897:Comorbidity; D018450:Disease Progression; D005240:Feasibility Studies; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D010641:Phenotype; D010865:Pilot Projects; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D012720:Severity of Illness Index
keywords: chronic obstructive pulmonary disease; clinical respiratory medicine; emphysema; infection and inflammation; viral infection