title: A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity.
abstract: OBJECTIVE
  The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and the risk of overweight/obesity remains controversial. A meta-analysis was conducted to evaluate the association between ACE I/D gene polymorphism and overweight/obesity susceptibility.
  
  
  METHODS
  All eligible studies were included in this meta-analysis by searching PubMed, Embase and Cochrane databases through April 2013 according to a predefined criteria.
  
  
  RESULTS
  Fourteen case-control studies including 3371 cases and 4490 controls were recruited for the analysis of the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. A significant association was observed between DD genotype and overweight/obesity risk in overall populations and Africans (p=0.014 and 0.010, respectively). D allele was associated with the risk of overweight/ obesity in Africans (p=0.026). However, II genotype might not be a protective factor against overweight/obesity risk in overall populations, Africans, Caucasians and Asians.
  
  
  CONCLUSIONS
  DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations, particularly in Africans. D allele is a risk factor for the overweight/obesity susceptibility in Africans. Further larger studies are needed to confirm our findings.
authors.affiliation: Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Song
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, China edjk123456@sina.com.
authors.forename: Songming
authors.initials: S
authors.lastname: Huang
mesh_terms: D044383:Black People / Q000235:genetics; D016001:Confidence Intervals; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D009765:Obesity / Q000201:enzymology* / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; gene polymorphism; meta-analysis; overweight/obesity