title: Synthesis of13C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites.
abstract: Synthesis of the13C2-labelled analogues of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene and its active metabolites are described. The method entails Pd-catalyzed Suzuki-Miyaura coupling of a naphthalene boronic acid with 2-bromobenzene-1,3-dialdehyde followed by Wittig reaction of the product with13CH2=PPh3.
authors.affiliation: Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637.
authors.forename: Chongzhao
authors.initials: C
authors.lastname: Ran
authors.forename: Daiwang
authors.initials: D
authors.lastname: Xu
authors.forename: Qing
authors.initials: Q
authors.lastname: Dai
authors.forename: Trevor M
authors.initials: TM
authors.lastname: Penning
authors.forename: Ian A
authors.initials: IA
authors.lastname: Blair
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Harvey