title: Method of continuous variations: applications of job plots to the study of molecular associations in organometallic chemistry.
abstract: Applications of the method of continuous variations (MCV or the Method of Job) to problems of interest to organometallic chemists are described. MCV provides qualitative and quantitative insights into the stoichiometries underlying association of m molecules of A and n molecules of B to form A(m)B(n) . Applications to complex ensembles probe associations that form metal clusters and aggregates. Job plots in which reaction rates are monitored provide relative stoichiometries in rate-limiting transition structures. In a specialized variant, ligand- or solvent-dependent reaction rates are dissected into contributions in both the ground states and transition states, which affords insights into the full reaction coordinate from a single Job plot. Gaps in the literature are identified and critiqued.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, NY 14853-1301 (USA) http://collum.chem.cornell.edu/
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Renny
authors.forename: Laura L
authors.initials: LL
authors.lastname: Tomasevich
authors.forename: Evan H
authors.initials: EH
authors.lastname: Tallmadge
authors.forename: David B
authors.initials: DB
authors.lastname: Collum
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D009942:Organometallic Compounds; D012997:Solvents; D028561:Transition Elements
keywords: aggregation; alkali metals; organometallics; reaction kinetics; transition metals