title: Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells.
abstract: We have recently shown that the combination of chemical motifs of vorinostat () and ferrocifen () in the single hybrid produced beneficial effects in terms of antiproliferative activity of both agents against cancer cells. Since hydroxylation of to form hydroxyferrocifen () improves the biological response, we explore in this work the anticancer effects of a new family of hybrid phenolic compounds bearing some molecular features of , and . Results concerning their cytotoxicity on both triple-negative MDA-MB-231 and hormone-dependent MCF-7 breast cancer cells are reported here. Organometallic compounds showed better antiproliferative activities than organic analogs. For instance, (IC50 = 1.5 μM) was around seven times more active than (IC50 = 10.9 μM) against MCF-7 cells. In the case of triple-negative MDA-MB-231 cells, the IC50 values for ferrocene compounds are in the range of 1.3-4.5 μM and those for organic derivatives are 5.2-34.5 μM. Studies concerning the isomerization and redox behaviors of these compounds are also presented. Despite the potential of to exhibit ex cellulo redox activation, it seems that this feature is not completely expressed in cellulo. This surprising behavior is related to the driving effect of the side chain to direct the new constructs to different targets.
authors.affiliation: Laboratoire Charles Friedel UMR CNRS 7223, Chimie ParisTech (Ecole Nationale Supérieure de Chimie de Paris), 11, rue Pierre et Marie Curie, Paris F75231 Paris cedex 05, France. siden-top@chimie-paristech.fr gerard-jaouen@chimie-paristech.fr.
authors.forename: José de Jesús
authors.initials: Jde J
authors.lastname: Cázares-Marinero
authors.forename: Siden
authors.initials: S
authors.lastname: Top
authors.forename: Anne
authors.initials: A
authors.lastname: Vessières
authors.forename: Gérard
authors.initials: G
authors.lastname: Jaouen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004355:Drug Stability; D004563:Electrochemistry; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007536:Isomerism; D007700:Kinetics; D061986:MCF-7 Cells; D010084:Oxidation-Reduction; D064726:Triple Negative Breast Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D005296:Ferrous Compounds; C514120:ferrocifen