title: Paraneoplastic cerebellar degeneration caused by ovarian clear-cell carcinoma.
abstract: Paraneoplastic cerebellar degeneration is a paraneoplastic neurological syndrome caused by the remote effect of certain systemic cancers and is characterized by subacute cerebellar symptoms. A 62-year-old woman suffering from unidentified cerebellar symptoms was admitted to our hospital. Paraneoplastic cerebellar degeneration was suspected and ovarian cancer was detected after the systemic examination for malignancy. The symptoms of vertigo and dysarthria were improved a little after surgical operation and treatments of γ-globulin, steroid pulse and tacrolimus hydrate. The cerebellar symptoms of paraneoplastic cerebellar degeneration are often evident prior to detection of malignancy. It is important to perform systemic examination for malignancy in case of unidentified cerebellar symptoms.
authors.affiliation: Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan; Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan; Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Negishi
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Noguchi
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: N
authors.initials: N
authors.lastname: Kawai
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications* / Q000175:diagnosis; D000906:Antibodies / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis; D020362:Paraneoplastic Cerebellar Degeneration / Q000097:blood / Q000209:etiology*
chemical_list: D000906:Antibodies; C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins
keywords: Yo antibody; ovarian cancer; paraneoplastic cerebellar degeneration; paraneoplastic neurological syndrome; tacrolimus hydrate