title: Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus.
abstract: OBJECTIVE
  To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC).
  
  
  METHODS
  Patients were divided into two groups as the accelerated CXL group and the conventional CXL group. The uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA), refraction and keratometric values were measured preoperatively and postoperatively. The data of the two groups were compared statistically.
  
  
  RESULTS
  The mean UDVA and CDVA were better at the six month postoperative when compared with preoperative values in two groups. While change in UDVA and CDVA was statistically significant in the accelerated CXL group (p = 0.035 and p = 0.047, respectively), it did not reach statistical significance in the conventional CXL group (p = 0.184 and p = 0.113, respectively). The decrease in the mean corneal power (Km) and maximum keratometric value (Kmax) were statistically significant in both groups (p = 0.012 and 0.046, respectively in the accelerated CXL group, p = 0.012 and 0.041, respectively, in the conventional CXL group). There was no statistically significant difference in visual and refractive results between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  Refractive and visual results of the accelerated CXL method and the conventional CXL method for the treatment of KC in short time period were similar. The accelerated CXL method faster and provide high throughput of the patients.
authors.affiliation: Department of Ophthalmology, Dicle University School of Medicine , Diyarbakir , Turkey and.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Cınar
authors.forename: Abdullah Kürşat
authors.initials: AK
authors.lastname: Cingü
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Türkcü
authors.forename: Tuba
authors.initials: T
authors.lastname: Çınar
authors.forename: Harun
authors.initials: H
authors.lastname: Yüksel
authors.forename: Zeynep Gürsel
authors.initials: ZG
authors.lastname: Özkurt
authors.forename: Ihsan
authors.initials: I
authors.lastname: Çaça
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012029:Refraction, Ocular; D012256:Riboflavin / Q000627:therapeutic use*; D014466:Ultraviolet Rays; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D011838:Radiation-Sensitizing Agents; D003094:Collagen; D012256:Riboflavin
keywords: Accelerated cross-linking; cross-linking; keratoconus