title: Continuing clozapine with granulocyte colony-stimulating factor in patients with neutropenia.
abstract: BACKGROUND
  The current guidelines dictate that clozapine should be stopped following the emergence of neutropenia. Various alternative approaches have been tried in the past, among them one rarely used alternative being to continue treatment with clozapine with coprescription of granulocyte colony-stimulating factor (G-CSF).
  
  
  OBJECTIVE
  In this case series we aim to describe the treatment and progress of a number of patients in a secure psychiatric hospital in the UK. These patients were restarted on clozapine in combination with G-CSF, in spite of previous neutropenia associated with clozapine treatment.
  
  
  CONCLUSIONS
  We hope that this case series will raise the profile of a potentially effective alternative to discontinuing clozapine after neutropenia.
authors.affiliation: Consultant in Forensic Psychiatry, Bracton Centre, Bracton Lane, Dartford, Kent DA2 7AF, UK.
authors.forename: Al Aditya
authors.initials: AA
authors.lastname: Khan
authors.forename: Jake
authors.initials: J
authors.lastname: Harvey
authors.forename: Samrat
authors.initials: S
authors.lastname: Sengupta
keywords: clozapine; clozapine-induced neutropenia; granulocyte colony-stimulating factor