title: Combinatorial synthesis of benzimidazole-azo-phenol derivatives as antifungal agents.
abstract: A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively.
authors.forename: Yazhen
authors.initials: Y
authors.lastname: Ke
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhi
authors.forename: Xiang
authors.initials: X
authors.lastname: Yu
authors.forename: Guodong
authors.initials: G
authors.lastname: Ding
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China. orgxuhui@nwsuaf.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000528:Alternaria / Q000187:drug effects / Q000254:growth & development; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects / Q000254:growth & development; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology; D010944:Plants / Q000382:microbiology; D004718:Saccharomycetales / Q000187:drug effects / Q000254:growth & development; D020037:Sordariales / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D001391:Azo Compounds; D001562:Benzimidazoles; D005659:Fungicides, Industrial; D010080:Oxazoles; D010636:Phenols; C531211:hymexazol