title: Factors predictive of clinical pregnancy in the first intrauterine insemination cycle of 306 couples with favourable female patient characteristics.
abstract: The objective of this study was to evaluate the factors predictive of clinical pregnancy in the first superovulation/intrauterine insemination (SO/IUI) cycle of couples with favourable female characteristics. We analyzed retrospectively the first SO/IUI cycle of 306 infertile couples with mild male factor infertility and unexplained infertility. The women had a favourable prognosis in terms of ovarian reserve. Univariate logistic regression analyses identified body mass index (BMI) [odds ratio (OR) = 0.9, P = 0.014], sperm concentration [OR = 1.007, P = 0.007] and inseminating motile sperm count (IMC) [OR = 1.007, P = 0.032] as significant predictive factors of clinical pregnancy. Multivariate logistic regression analysis identified BMI [OR = 0.87, P = 0.008] and sperm concentration [OR = 1.008, P = 0.011] as significant factors. Pregnant and non-pregnant groups did not differ significantly in terms of the age and smoking status of the woman, duration and type of infertility, length of the stimulation, total gonadotropin dosage or antral follicle count. Of the female characteristics investigated, BMI was the most significant predictive factor of clinical pregnancy in the first SO/IUI cycle of couples with unexplained or mild male factor infertility and favourable female characteristics. In overweight women, weight loss should be advised before starting SO/IUI. Sperm concentration and IMC were significant male predictive factors for clinical pregnancy in the first SO/IUI.
authors.affiliation: Department of Obstetrics and Gynecology, Eskisehir Osmangazi University School of Medicine , Eskisehir , Turkey.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Aydin
authors.forename: Hikmet
authors.initials: H
authors.lastname: Hassa
authors.forename: Tufan
authors.initials: T
authors.lastname: Oge
authors.forename: Vehbi Yavuz
authors.initials: VY
authors.lastname: Tokgoz
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy; D007317:Insemination, Artificial, Homologous; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D050177:Overweight / Q000150:complications; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D013076:Sperm Count; D016896:Treatment Outcome