title: [Long-term dynamics of gastrointestinal symptoms after cholecystectomy for the treatment of cholelithiasis].
abstract: The aim of the work was to analyse dynamics of gastrointestinal symptoms and risk factors at different periods after cholecystectomy (CCE) in patients with cholelithiasis (CL). It was a prospective open cohort observational study with interviewing the patients before, 6 and 36 months after cholecystectomy for the treatment of CL. The pain symptom of CL persisted in 65.9% of the patients till the 6th month after CCE and in 57.3% of the patients till the 36th month. The logistic univariant analysis showed high probability of persistence and/or appearance of biliary pain within 6 months after surgery in patients suffering biliary colic before it (OR = 5.3, p = 0.01) and having hereditary aggravation of CL (OR = 2.7, p = 0.38). The relationship between biliary pain and planned surgical intervention for the treatment of CL was documented 3 years after the operation (OR = 2.6, p = 0.018). Similar relationship was revealed after 6 and 36 months (OR = 3.8, p = 0.002). Biliary pain within 6 months after CL was an independent prognostic factor of its development within the next 3 years. Other increasingly severe gastrointestinal symptoms were heartburn, intolerance of greasy food, and disturbed intestinal passage as a result of biliary insufficiency or disordered intestinal motility. The above relationships between gastrointestinal symptoms may be used to predict their appearance within 6 months after CL.
authors.forename: M F
authors.initials: MF
authors.lastname: Osipenko
authors.forename: N V
authors.initials: NV
authors.lastname: Litvinova
authors.forename: N B
authors.initials: NB
authors.lastname: Voloshina
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Frolov
mesh_terms: D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000503:physiopathology / Q000601:surgery*; D002763:Cholecystectomy / Q000009:adverse effects*; D002769:Cholelithiasis / Q000601:surgery*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors