title: JIS definition identified more Malaysian adults with metabolic syndrome compared to the NCEP-ATP III and IDF criteria.
abstract: Metabolic syndrome (MetS) is a steering force for the cardiovascular diseases epidemic in Asia. This study aimed to compare the prevalence of MetS in Malaysian adults using NCEP-ATP III, IDF, and JIS definitions, identify the demographic factors associated with MetS, and determine the level of agreement between these definitions. The analytic sample consisted of 8,836 adults aged ≥30 years recruited at baseline in 2007-2011 from the Cardiovascular Risk Prevention Study (CRisPS), an ongoing, prospective cohort study involving 18 urban and 22 rural communities in Malaysia. JIS definition gave the highest overall prevalence (43.4%) compared to NCEP-ATP III (26.5%) and IDF (37.4%), P < 0.001. Indians had significantly higher age-adjusted prevalence compared to other ethnic groups across all MetS definitions (30.1% by NCEP-ATP III, 50.8% by IDF, and 56.5% by JIS). The likelihood of having MetS amongst the rural and urban populations was similar across all definitions. A high level of agreement between the IDF and JIS was observed (Kappa index = 0.867), while there was a lower level of agreement between the IDF and NCEP-ATP III (Kappa index = 0.580). JIS definition identified more Malaysian adults with MetS and therefore should be recommended as the preferred diagnostic criterion.
authors.affiliation: Primary Care Medicine Discipline, Faculty of Medicine, Universiti Teknologi MARA, 47000 Sungai Buloh, Selangor, Malaysia ; Centre for Translational Research and Epidemiology (CenTRE), Faculty of Medicine, Universiti Teknologi MARA, 47000 Sungai Buloh, Selangor, Malaysia.
authors.forename: Anis Safura
authors.initials: AS
authors.lastname: Ramli
authors.forename: Aqil Mohammad
authors.initials: AM
authors.lastname: Daher
authors.forename: Mohamed Noor Khan
authors.initials: MN
authors.lastname: Nor-Ashikin
authors.forename: Nafiza
authors.initials: N
authors.lastname: Mat-Nasir
authors.forename: Kien Keat
authors.initials: KK
authors.lastname: Ng
authors.forename: Maizatullifah
authors.initials: M
authors.lastname: Miskan
authors.forename: Krishnapillai S
authors.initials: KS
authors.lastname: Ambigga
authors.forename: Farnaza
authors.initials: F
authors.lastname: Ariffin
authors.forename: Md Yasin
authors.initials: MY
authors.lastname: Mazapuspavina
authors.forename: Suraya
authors.initials: S
authors.lastname: Abdul-Razak
authors.forename: Hasidah
authors.initials: H
authors.lastname: Abdul-Hamid
authors.forename: Fadhlina
authors.initials: F
authors.lastname: Abd-Majid
authors.forename: Najmin
authors.initials: N
authors.lastname: Abu-Bakar
authors.forename: Hapizah
authors.initials: H
authors.lastname: Nawawi
authors.forename: Khalid
authors.initials: K
authors.lastname: Yusoff
mesh_terms: D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012424:Rural Population; D014505:Urban Population