title: Olodaterol: first global approval.
abstract: Olodaterol (Striverdi(®) Respimat(®)) is a novel, long-acting, β2-adrenergic receptor agonist developed by Boehringer Ingelheim for the treatment of chronic obstructive pulmonary disease (COPD). The drug is delivered via the Respimat(®) Soft Mist™ inhaler. Olodaterol received its first global approval for the once-daily maintenance treatment of COPD in Canada and Russia, and submissions for regulatory approval have also been made in the USA, the EU and elsewhere. Phase II trials have been conducted in patients with asthma. The company is also developing a fixed-dose combination of olodaterol with tiotropium bromide, a long-acting anti-muscarinic agent, for the treatment of COPD. This article summarizes the milestones in the development of olodaterol leading to this first approval for COPD.
authors.affiliation: Adis R&D Insight, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, dru@adis.com.
authors.forename: Andrew
authors.initials: A
authors.lastname: Gibb
authors.forename: Lily P H
authors.initials: LP
authors.lastname: Yang
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000188:drug therapy; D048588:Benzoxazines / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D017322:Clinical Trials, Phase II as Topic; D006801:Humans; D009330:Nebulizers and Vaporizers; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D012602:Scopolamine Derivatives / Q000008:administration & dosage; D000069447:Tiotropium Bromide
chemical_list: D048588:Benzoxazines; D001993:Bronchodilator Agents; D012602:Scopolamine Derivatives; C549647:olodaterol; D000069447:Tiotropium Bromide