title: Release of bone markers in immediately loaded and nonloaded dental implants: a randomized clinical trial.
abstract: The aim of this study was to compare the release of bone markers during osseointegration of immediately loaded and nonloaded implants. Forty patients who were indicated for rehabilitation with dental implants randomly received either implant and prosthesis placement within 72 hours (group IM) or implant insertion and no prosthesis placement (group NL). Peri-implant crevicular fluid was collected immediately after implant insertion and 7, 15, 30, 60, 90, and 120 days after surgery and levels of osteoprotegerin, transforming growth factors, osteocalcin, osteopontin, and parathyroid hormone were evaluated using Luminex assay. Bleeding index and peri-implantar sulcus depth were also evaluated. The data were compared using statistical tests (α = 5%). No statistical difference was found regarding demographic and clinical parameters (p > .05). Transforming growth factors, osteoprotegerin, osteopontin, and parathyroid hormone presented an earlier release peak in group IM than in NL group (p < .05). Osteocalcin achieved higher levels in group IM versus group NL between 7 and 30 days of evaluation (p < .05). It may be concluded that earlier loading positively modulates bone mediators release around immediately loaded implants when compared with nonloaded dental implants.
authors.affiliation: Division of Maxillofacial Surgery, Paulista University, Sao Paulo, Brazil.
authors.forename: A J
authors.initials: AJ
authors.lastname: Prati
authors.forename: M Z
authors.initials: MZ
authors.lastname: Casati
authors.forename: F V
authors.initials: FV
authors.lastname: Ribeiro
authors.forename: F R
authors.initials: FR
authors.lastname: Cirano
authors.forename: G P
authors.initials: GP
authors.lastname: Pastore
authors.forename: S P
authors.initials: SP
authors.lastname: Pimentel
authors.forename: R C V
authors.initials: RC
authors.lastname: Casarin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001842:Bone and Bones / Q000737:chemistry*; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D057893:Immediate Dental Implant Loading; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D015675:Osteocalcin / Q000032:analysis; D053495:Osteopontin / Q000032:analysis; D053244:Osteoprotegerin / Q000032:analysis; D010281:Parathyroid Hormone / Q000032:analysis; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D011446:Prospective Studies; D016211:Transforming Growth Factor alpha / Q000032:analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015921:Dental Implants; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; C506030:TNFRSF11B protein, human; D016211:Transforming Growth Factor alpha; D015675:Osteocalcin; D053495:Osteopontin
keywords: biological markers; edentulous jaws; immediate dental implant loading; implant-supported dental prosthesis; osseointegration; osteogenesis