title: Extramedullary hematopoiesis in pyogenic granuloma.
abstract: Extramedullary hematopoiesis (EMH) suggests the presence of hematopoietic stem cells (HSC) outside bone marrow. EMH has been reported, albeit rarely, in pyogenic granuloma (PG), a polypoid lobular capillary hemangioma. However, statistical data have hitherto been lacking on the actual incidence of EMH in PG. Therefore, we here reviewed 157 consecutive cases using routine diagnostic surgical slides and found unequivocal EMH in 17 (10.8%). This indicates that EMH is a rather common finding in PG, which could thus have strong potential to be an important resource for the study of HSC.
authors.affiliation: Department of Pathology, Toda Chuo General Hospital, Saitama, Japan; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Sakda
authors.initials: S
authors.lastname: Waraasawapati
authors.forename: Supinda
authors.initials: S
authors.lastname: Koonmee
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kusama
authors.forename: Motoshige
authors.initials: M
authors.lastname: Kudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D017789:Granuloma, Pyogenic / Q000150:complications*; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: CD41; extramedullary hematopoiesis; glycophorin A; hematopoietic stem cells; myeloperoxidase; pyogenic granuloma