title: Reproductive risk factors for thyroid cancer: a prospective cohort study in Khon Kaen, Thailand.
abstract: BACKGROUND
  Because of the gender disparity in the incidence of thyroid cancer, this study aimed to determine the association between reproductive factors and thyroid cancer.
  
  
  METHODS
  A total of 10,767 eligible women from the Khon Kaen Cohort, recruited and interviewed between 1990 and 2001, were followed up until 2011. The data were linked to the Khon Kaen Population-Based Cancer Registry to detect thyroid cancer cases.
  
  
  RESULTS
  There was 17 thyroid cancer cases detected, an incidence of 11.2 per 100,000 person-years, of which 70.6 % were papillary tumors. The incidence was apparently greater among those with an early age of menarche, nulligravida women, and oral contraceptive users.
  
  
  CONCLUSIONS
  There was a trend for thyroid cancer to develop in relation to longer estrogen exposure. This evidence is inconclusive but warrants further investigation.
authors.affiliation: Department of Epidemiology, Faculty of Public Health, Khon Kaen Universtity, Khon Kaen, Thailand E-mail : patvat@kku.ac.th.
authors.forename: Wararat
authors.initials: W
authors.lastname: Sungwalee
authors.forename: Patravoot
authors.initials: P
authors.lastname: Vatanasapt
authors.forename: Siriporn
authors.initials: S
authors.lastname: Kamsa-Ard
authors.forename: Krittika
authors.initials: K
authors.lastname: Suwanrungruang
authors.forename: Supannee
authors.initials: S
authors.lastname: Promthet
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology*; D002277:Carcinoma / Q000453:epidemiology*; D002291:Carcinoma, Papillary; D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D020073:Gravidity; D006801:Humans; D015994:Incidence; D008572:Menarche; D008875:Middle Aged; D011446:Prospective Studies; D017584:Reproductive History; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D013785:Thailand / Q000453:epidemiology; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology*
chemical_list: D003276:Contraceptives, Oral