title: Synergistic anti-leukemic activity of imatinib in combination with a small molecule Grb2 SH2 domain binding antagonist.
authors.affiliation: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Luo
authors.affiliation: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
authors.affiliation: 1] The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA [2] Chemical Biology Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Burke
authors.affiliation: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Bottaro
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D051380:GRB2 Adaptor Protein / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy*; D035683:MicroRNAs / Q000502:physiology; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D018909:src Homology Domains
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; D035683:MicroRNAs; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D000444:Aldehyde Dehydrogenase