title: A transition metal carbonyl probe for use in a highly specific and sensitive SERS-based assay for glucose.
abstract: A triosmium carbonyl cluster-boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800-2200 cm(-1)), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.
authors.affiliation: Singapore Bioimaging Consortium, Agency for Science, Technology and Research , Singapore.
authors.forename: Kien Voon
authors.initials: KV
authors.lastname: Kong
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lam
authors.forename: Weber Kam On
authors.initials: WK
authors.lastname: Lau
authors.forename: Weng Kee
authors.initials: WK
authors.lastname: Leong
authors.forename: Malini
authors.initials: M
authors.lastname: Olivo
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D005947:Glucose / Q000032:analysis*; D006029:Glycosuria / Q000175:diagnosis*; D006801:Humans; D009992:Osmium / Q000737:chemistry; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D028561:Transition Elements; D009992:Osmium; D005947:Glucose