title: Post radiation skin tumors: basal cell carcinomas, squamous cell carcinomas and angiosarcomas. A review of this late effect of radiotherapy.
abstract: This review gives an overview of radiotherapy-induced malignant skin tumors as described in the present medical literature. Basal cell carcinomas are the most frequent post-radiation malignant skin tumors; however, specific incidence ratios are few and show ratios of 2%. Squamous cell carcinomas are briefly discussed, followed by post-radiation sarcomas. Most cases of post-radiation cutaneous sarcomas are angiosarcoma, malignant fibrous histiocytoma, leiomyosarcoma and fibrosarcoma. In cases of radiotherapy for breast cancer, angiosarcomas are the most frequently found malignant sarcomas worldwide (incidence 0.5%) in the irradiated area. We present 192 cases of angiosarcomas after radiotherapy for breast cancer. Also, the atypical vascular lesion, a benign vascular skin lesion occurring after radiotherapy, and the important differential diagnosis of angiosarcoma will be presented and discussed. Other skin tumors supposedly related to radiotherapy are occasionally published and summarized in this review. Because most radiation-induced malignant tumors occur many years after the initiation of radiotherapy and incidences are low, we suggest good instruction of patients regarding self control of the skin rather than a yearly follow-up.
authors.affiliation: Department of Dermatology, Venereology.
authors.forename: Edwin
authors.initials: E
authors.lastname: Cuperus
authors.affiliation: Department of Pathology.
authors.forename: Roos
authors.initials: R
authors.lastname: Leguit
authors.affiliation: Department of Radiotherapy and Oncology, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Miriam
authors.initials: M
authors.lastname: Albregts
authors.affiliation: Department of Dermatology, Venereology.
authors.forename: Johan
authors.initials: J
authors.lastname: Toonstra
mesh_terms: D002280:Basal Cell Carcinoma / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D006394:Hemangiosarcoma / Q000209:etiology*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology*
keywords: angiosarcoma; atypical vascular lesion; basal cell carcinoma; cutaneous tumors; post-radiation; radiotherapy