title: Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits.
abstract: This study investigated the possible anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits in selected experimental animal models. Anti-inflammatory activity of Pedalium murex Linn., with doses of 200 mg/kg and 400 mg/kg, p.o., was evaluated by Lambda-carrageenan induced paw oedema in Wistar albino rats; analgesic activity with doses of 280 mg/kg and 560 mg/kg, p.o., was evaluated by hot plate method and acetic acid induced writhing method in Swiss albino mice; and antipyretic activity with doses of 110 mg/kg and 220 mg/kg, p.o., was evaluated in New Zealand white rabbits by injecting gram -ve lipopolysaccharide obtained from E. coli. Results were analysed by one way ANOVA followed by Dunnet's multiple comparison test. Pedalium murex Linn. showed significant anti-inflammatory activity from 15 min to 180 min as compared to vehicle treated animals. It was comparable to diclofenac sodium at 180 min. The extract did not prolong the reaction time on hot plate method but significantly reduced the number of writhing after acetic acid administration. Also the extract did not show any antipyretic activity on lipopolysaccharide induced pyrexia. It is therefore concluded that the ethanolic extract of Pedalium murex Linn. fruits has an anti-inflammatory and peripheral analgesic effects.
authors.affiliation: Department of Pharmacology, Government Medical College, Bhavnagar - 364001, Gujarat, India.
authors.forename: Mahendra K
authors.initials: MK
authors.lastname: Patel
authors.forename: Divyesh R
authors.initials: DR
authors.lastname: Mandavia
authors.forename: Tejas K
authors.initials: TK
authors.lastname: Patel
authors.forename: Manish J
authors.initials: MJ
authors.lastname: Barvaliya
authors.forename: C B
authors.initials: CB
authors.lastname: Tripathi
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D058633:Antipyretics / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced; D005638:Fruit; D006358:Hot Temperature; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D029601:Pedaliaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D008070:Lipopolysaccharides; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid
keywords: Analgesic; Anti-inflammatory; Antipyretic; Carrageenan; Pedalium murex Linn.