title: A genome-wide association study of third molar agenesis in Japanese and Korean populations.
abstract: Tooth agenesis is the most common developmental anomaly of human dentition, occurring most often in the third molar (wisdom tooth). It is affected by genetic variation, so this study aimed to identify susceptibility genes associated with third molar agenesis. Examination of panoramic radiographs and medical history about third molar extraction were used to diagnose third molar agenesis. We then conducted a genome-wide association study of 149 cases with at least one-third molar agenesis and 338 controls from Japan and Korea using the Illumina HumanOmniExpress BeadChip. After rigorous quality-control filtering, approximately 550 000 single-nucleotide polymorphisms (SNPs) were analyzed in association tests with the status. We identified three SNPs showing evidence of association at P<1 × 10(-5) and 69 SNPs showing evidence of association at P<1 × 10(-4). SNP rs1469622, which maps to an intron of THSD7B (thrombospondin, type I, domain containing 7B) on chromosome 2, showed the strongest association (combined odds ratio=1.88, 95% confidence interval=1.43-2.47, P=7.5 × 10(-6)). The identified SNPs may be considered candidates for future replication studies in independent samples.
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: Shugo
authors.initials: S
authors.lastname: Haga
authors.affiliation: Division of Human Genetics, National Institute of Genetics, Shizuoka, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakaoka
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Orthodontics, School of Dentistry, Biomedical Research Institute, Pusan National University Hospital, Seogu, Busan, South Korea.
authors.forename: Yong-Il
authors.initials: YI
authors.lastname: Kim
authors.affiliation: Aoyama R Orthodontics, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Samoto
authors.affiliation: Ohno Orthodontic Clinic, Yokohama, Kanagawa, Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Ohno
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: Koshu
authors.initials: K
authors.lastname: Katayama
authors.affiliation: Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Department of Orthodontics, School of Dentistry, Biomedical Research Institute, Pusan National University Hospital, Seogu, Busan, South Korea.
authors.forename: Soo-Byung
authors.initials: SB
authors.lastname: Park
authors.affiliation: Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kimura
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Maki
authors.affiliation: Division of Human Genetics, National Institute of Genetics, Shizuoka, Japan.
authors.forename: Ituro
authors.initials: I
authors.lastname: Inoue
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008964:Molar, Third / Q000002:abnormalities*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D056910:Republic of Korea; D014071:Tooth Abnormalities / Q000235:genetics*