title: Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis.
abstract: DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1 g/d, DHA proved to be effective in lowering blood platelet function and exhibited an 'antioxidant' effect. However, this was no longer the case following 1.6 g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA.
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Lagarde
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Véricel
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Calzada
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Inserm, UMR 773, Université Paris 7 Denis Diderot, Faculté de Médecine, Paris, France.
authors.forename: Fathi
authors.initials: F
authors.lastname: Driss
authors.affiliation: Université de Lyon, UMR 1060 Inserm (CarMeN), INSA-Lyon, IMBL, Villeurbanne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Guichardant
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D001792:Blood Platelets / Q000187:drug effects; D018957:CD59 Antigens / Q000096:biosynthesis / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004281:Docosahexaenoic Acids / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007962:Leukocytes; D058945:Lipoxygenases / Q000097:blood*; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D018957:CD59 Antigens; D008078:Cholesterol, LDL; D004041:Dietary Fats; D004281:Docosahexaenoic Acids; D058945:Lipoxygenases