title: Resting energy expenditure and gut microbiota in obese and normal weight subjects.
abstract: OBJECTIVE
  It is suggested that gut microbiota play a role in the pathogenesis of obesity enhancing energy utilization from digested food. The influence of gut microbiota on resting energy expenditure (REE) has not been evaluated yet.
  
  
  OBJECTIVE
  The aim of the study is to assess the composition on gut microbiota and its association with REE in obese and normal weight subjects.
  
  
  METHODS
  REE measurement and semi-quantitative analysis of gut microbiota composition in aerobic and anaerobic conditions were performed in 50 obese and 30 normal weight subjects without concomitant diseases.
  
  
  RESULTS
  A count of bacterial colony was greater in obese than in normal weight subjects. However, the proportion of Bacteroides spp. and Firmicutes was similar in both study groups. A positive correlation between REE (kcal/d) and total bacterial count (r = 0.26, p < 0.05), as well as between REE and the percentage of Firmicutes (r = -0.24, p < 0.05) was found. The multiple regression analysis did not prove an independent impact of total bacterial as well as Bacteroides spp. and Firmicutes counts on REE.
  
  
  CONCLUSIONS
  The composition of gut microbiota is not associated with the level of resting energy expenditure. The proportion of Bacteroides and Firmicutes in gut microbiota is not related to body mass.
authors.affiliation: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland. pkocelak@sum.edu.pl.
authors.forename: P
authors.initials: P
authors.lastname: Kocełak
authors.forename: A
authors.initials: A
authors.lastname: Zak-Gołąb
authors.forename: B
authors.initials: B
authors.lastname: Zahorska-Markiewicz
authors.forename: M
authors.initials: M
authors.lastname: Aptekorz
authors.forename: M
authors.initials: M
authors.lastname: Zientara
authors.forename: G
authors.initials: G
authors.lastname: Martirosian
authors.forename: J
authors.initials: J
authors.lastname: Chudek
authors.forename: M
authors.initials: M
authors.lastname: Olszanecka-Glinianowicz
mesh_terms: D000328:Adult; D001439:Bacteroides / Q000302:isolation & purification; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000382:microbiology