title: Expression of follicular helper T-cell markers in primary cutaneous T-cell lymphoma.
abstract: The follicular helper T cells (TFH) seemed to be expressed in several subsets of T-cell lymphomas. However, their expression in cutaneous T-cell lymphomas (CTCLs) has been rarely described. We investigated the clinical features, histopathological morphology, and expression of TFH markers in CTCLs. Forty-nine patients (24 men and 25 women) diagnosed with CTCL were examined, 25 patients with mycosis fungoides (MF) and 24 with other CTCLs. Immunohistochemical staining for CD10, Bcl-6, inducible costimulator, CXCL13, and PD-1 were performed. Relation between PD-1 and clinical course in MF was evaluated. PD-1 was detected in 21 of 25 (84.0%) MF cases and in 11 of 24 (45.8%) other CTCL cases. Bcl-6, CXCL13, inducible costimulator, and CD10 were occasionally expressed in most T-cell lymphomas, including MF. The staining for PD-1 was negative in all the MF cases with large-cell transformation. No correlation was observed between disease course and PD-1 expression rate in the MF cases. In conclusion, among the TFH markers, PD-1 was most frequently expressed in CTCL. PD-1 was expressed in most MF. PD-1 expression rates were significantly higher in MF than in other CTCLs.
authors.affiliation: Departments of *Dermatology, and †Pathology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Park
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Han
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Kang
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
authors.forename: You Chan
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000096:biosynthesis*; D016176:T-Lymphocyte Subsets / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor