title: Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages.
abstract: Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus (HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow (BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the major HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.
authors.affiliation: Davide Gibellini, Alberto Clò, Silvia Morini, Anna Miserocchi, Maria Carla Re, Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, 40138 Bologna, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Gibellini
authors.forename: Alberto
authors.initials: A
authors.lastname: Clò
authors.forename: Silvia
authors.initials: S
authors.lastname: Morini
authors.forename: Anna
authors.initials: A
authors.lastname: Miserocchi
authors.forename: Cristina
authors.initials: C
authors.lastname: Ponti
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Re
keywords: Erythrocytes; Haematopoietic progenitor cells; Human immunodeficiency virus; Megakaryocytes; Virology