title: The clinical outcome of end-stage renal disease patients who return to peritoneal dialysis after renal allograft failure.
abstract: BACKGROUND
  With the increased numbers of kidney transplantations, more patients return to dialysis after graft loss (DAGL). The aim of this study was to investigate the safety and efficacy of peritoneal dialysis (PD) after graft loss compared with transplant-naive PD patients (TN-PD).
  
  
  METHODS
  This study was conducted on 715 patients who started PD between 1988 and 2009, including 47 who started PD after allograft loss (DAGL-PD) and 668 in the (TN-PD) group.
  
  
  RESULTS
  The mean ages were 40.8 ± 10.7 in DAGL-PD group and 51.03 ± 14.20 in TN-PD group (P < .01). The most common cause of end-stage renal disease in DAGL was primary glomerulonephritis (76.6%), but it was diabetes mellitus (38.9%) in the TN-PD group (P < .05). Patient survival rates at 1, 5, and 10 years were not different: 100%, 86%, and 57% versus 91%, 70%, and 62%, respectively. PD survival rate at 1, 5, and 10 years did not show significant differences: 98%, 95%, and 88% versus 95%, 80%, and 66%, respectively. The most common causes of death in both groups were infection (DAGL, 26.7%; TN-PD, 24.5%) followed by cardiovascular disease (DAGL, 20.0%; TN-PD, 19.6%); the distribution of causes did not differ significantly (P > .05).
  
  
  CONCLUSIONS
  The clinical outcomes of PD in DAGL group were comparable with those of TN-PD patients. Therefore, PD could be considered as a dialysis modality for patients who experience allograft failure.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: K S
authors.initials: KS
authors.lastname: Yang
authors.forename: J-I
authors.initials: JI
authors.lastname: Kim
authors.forename: I S
authors.initials: IS
authors.lastname: Moon
authors.forename: B S
authors.initials: BS
authors.lastname: Choi
authors.forename: C W
authors.initials: CW
authors.lastname: Park
authors.forename: C W
authors.initials: CW
authors.lastname: Yang
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
mesh_terms: D000328:Adult; D064591:Allografts; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery* / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate