title: The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis.
abstract: Onychomycosis is a common disease, accounting for up to 50% of all ungual pathologies. We have been developing a clinical trial (ClinicalTrials.gov: NCT01528813) using a 2940nm Er:YAG laser to fractionally ablate human nails in vivo, aiming to increase topical amorolfine lacquer delivery to the nail unit, increasing the efficacy of topical treatment of distal and lateral subungual onychomycosis. Partial results have shown an increase in areas of nail plate free of disease. We believe that ablative lasers can increase the efficacy of topical onychomycosis treatment.
authors.affiliation: University of Brasilia, BrasiliaDF, Brazil.
authors.forename: Orlando Oliveira de
authors.initials: OO
authors.lastname: Morais
authors.forename: Izelda Maria Carvalho
authors.initials: IM
authors.lastname: Costa
authors.forename: Ciro Martins
authors.initials: CM
authors.lastname: Gomes
authors.forename: Dayane Higa
authors.initials: DH
authors.lastname: Shinzato
authors.forename: Guilherme Marreta Cavalcanti
authors.initials: GM
authors.lastname: Ayres
authors.forename: Rayane Marques
authors.initials: RM
authors.lastname: Cardoso
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000627:therapeutic use*; D046169:Dermoscopy; D006801:Humans; D007764:Lacquer; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D009025:Morpholines / Q000627:therapeutic use*; D014009:Onychomycosis / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009025:Morpholines; C038974:amorolfine