title: [Coronary artery disease in patients with psoriasis].
abstract: In previous reports, psoriasis was associated with an increased rate of coronary artery disease. These data has not been investigated in our population. We performed a cross-sectional study analyzing data from electronic medical records of a health system in Buenos Aires. We included all patients older than 18 years diagnosed with psoriasis between January 1, 2003 and July 31, 2011 and compared them with a control group. Controls were selected randomly by strata of age and sex from the same health system in a 2:1 ratio. We determined the prevalence of cardiovascular risk factors and coronary heart disease. We analyzed the association between psoriasis and coronary artery disease by both univariate and multivariate analyzes. In total, 3 833 subjects were included (1 286 with psoriasis and 2 547 controls). The prevalence of hypertension (50% vs. 38%, p < 0.001), smoking (25% vs. 17%, p < 0.001), diabetes (12% vs. 8%, p < 0.001) and coronary artery disease (4.98% vs. 3.06%, p = 0.003) were higher in the psoriasis group compared to controls. Regardless age and the presence or absence of diabetes, hypertension or smoking, there was a significant association between coronary artery disease and psoriasis (OR 1.48, CI95% 1.04-2.11, p = 0.03). In conclusion, in this population of Buenos Aires, psoriasis patients had a higher prevalence of diabetes, hypertension, smoking, and coronary artery disease. The association between psoriasis and coronary artery disease was independent of the risk factors explored.
authors.affiliation: Servicio de Cardiología, Hospital Italiano de Buenos Aires.
authors.forename: Walter
authors.initials: W
authors.lastname: Masson
authors.forename: María L
authors.initials: ML
authors.lastname: Galimberti
authors.forename: Carolina L
authors.initials: CL
authors.lastname: Anselmi
authors.forename: Arturo
authors.initials: A
authors.lastname: Cagide
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Galimberti
mesh_terms: D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000453:epidemiology; D057286:Electronic Health Records; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011565:Psoriasis / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D018709:Statistics, Nonparametric
keywords: coronary artery disease; diabetes; hypertension; psoriasis; smoking