title: First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.
abstract: BACKGROUND
  There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS).
  
  
  RESULTS
  Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS (3.9 ± 4.6, P = 0.02 versus control; 5.7 ± 5.6, P = 0.001 versus control; and 1 ± 0.4 ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI (P = 0.33).
  
  
  CONCLUSIONS
  This finding suggests that serotonin could participate to the pathophysiology of TTC.
authors.affiliation: Inserm, Metabolic and Cardiovascular Disease Institute of Rangueil, 31432 Toulouse, France ; Paul Sabatier University, 31062 Toulouse, France ; Department of Pharmacy, University Hospital Center, 31059 Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Rouzaud Laborde
authors.forename: C
authors.initials: C
authors.lastname: Delmas
authors.forename: J
authors.initials: J
authors.lastname: Mialet-Perez
authors.forename: N
authors.initials: N
authors.lastname: Pizzinat
authors.forename: C
authors.initials: C
authors.lastname: Biendel-Picquet
authors.forename: N
authors.initials: N
authors.lastname: Boudou
authors.forename: N
authors.initials: N
authors.lastname: Dumonteil
authors.forename: O
authors.initials: O
authors.lastname: Spreux-Varoquaux
authors.forename: D
authors.initials: D
authors.lastname: Carrié
authors.forename: M
authors.initials: M
authors.lastname: Galinier
authors.forename: A
authors.initials: A
authors.lastname: Parini
authors.forename: O
authors.initials: O
authors.lastname: Lairez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D017682:Myocardial Stunning / Q000097:blood; D012701:Serotonin / Q000097:blood* / Q000502:physiology; D013312:Stress, Physiological; D013315:Stress, Psychological; D054549:Takotsubo Cardiomyopathy / Q000097:blood* / Q000209:etiology / Q000503:physiopathology
chemical_list: D012701:Serotonin