title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
abstract: Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
authors.forename: J C
authors.initials: JC
authors.lastname: Lambert
authors.forename: C A
authors.initials: CA
authors.lastname: Ibrahim-Verbaas
authors.forename: D
authors.initials: D
authors.lastname: Harold
authors.forename: A C
authors.initials: AC
authors.lastname: Naj
authors.forename: R
authors.initials: R
authors.lastname: Sims
authors.forename: C
authors.initials: C
authors.lastname: Bellenguez
authors.forename: A L
authors.initials: AL
authors.lastname: DeStafano
authors.forename: J C
authors.initials: JC
authors.lastname: Bis
authors.forename: G W
authors.initials: GW
authors.lastname: Beecham
authors.forename: B
authors.initials: B
authors.lastname: Grenier-Boley
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: T A
authors.initials: TA
authors.lastname: Thorton-Wells
authors.forename: N
authors.initials: N
authors.lastname: Jones
authors.forename: A V
authors.initials: AV
authors.lastname: Smith
authors.forename: V
authors.initials: V
authors.lastname: Chouraki
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: M A
authors.initials: MA
authors.lastname: Ikram
authors.forename: D
authors.initials: D
authors.lastname: Zelenika
authors.forename: B N
authors.initials: BN
authors.lastname: Vardarajan
authors.forename: Y
authors.initials: Y
authors.lastname: Kamatani
authors.forename: C F
authors.initials: CF
authors.lastname: Lin
authors.forename: A
authors.initials: A
authors.lastname: Gerrish
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Kunkle
authors.forename: M L
authors.initials: ML
authors.lastname: Dunstan
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: M T
authors.initials: MT
authors.lastname: Bihoreau
authors.forename: S H
authors.initials: SH
authors.lastname: Choi
authors.forename: C
authors.initials: C
authors.lastname: Reitz
authors.forename: F
authors.initials: F
authors.lastname: Pasquier
authors.forename: C
authors.initials: C
authors.lastname: Cruchaga
authors.forename: D
authors.initials: D
authors.lastname: Craig
authors.forename: N
authors.initials: N
authors.lastname: Amin
authors.forename: C
authors.initials: C
authors.lastname: Berr
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: P L
authors.initials: PL
authors.lastname: De Jager
authors.forename: V
authors.initials: V
authors.lastname: Deramecourt
authors.forename: J A
authors.initials: JA
authors.lastname: Johnston
authors.forename: D
authors.initials: D
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Lovestone
authors.forename: L
authors.initials: L
authors.lastname: Letenneur
authors.forename: F J
authors.initials: FJ
authors.lastname: Morón
authors.forename: D C
authors.initials: DC
authors.lastname: Rubinsztein
authors.forename: G
authors.initials: G
authors.lastname: Eiriksdottir
authors.forename: K
authors.initials: K
authors.lastname: Sleegers
authors.forename: A M
authors.initials: AM
authors.lastname: Goate
authors.forename: N
authors.initials: N
authors.lastname: Fiévet
authors.forename: M W
authors.initials: MW
authors.lastname: Huentelman
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: K
authors.initials: K
authors.lastname: Brown
authors.forename: M I
authors.initials: MI
authors.lastname: Kamboh
authors.forename: L
authors.initials: L
authors.lastname: Keller
authors.forename: P
authors.initials: P
authors.lastname: Barberger-Gateau
authors.forename: B
authors.initials: B
authors.lastname: McGuiness
authors.forename: E B
authors.initials: EB
authors.lastname: Larson
authors.forename: R
authors.initials: R
authors.lastname: Green
authors.forename: A J
authors.initials: AJ
authors.lastname: Myers
authors.forename: C
authors.initials: C
authors.lastname: Dufouil
authors.forename: S
authors.initials: S
authors.lastname: Todd
authors.forename: D
authors.initials: D
authors.lastname: Wallon
authors.forename: S
authors.initials: S
authors.lastname: Love
authors.forename: E
authors.initials: E
authors.lastname: Rogaeva
authors.forename: J
authors.initials: J
authors.lastname: Gallacher
authors.forename: P
authors.initials: P
authors.lastname: St George-Hyslop
authors.forename: J
authors.initials: J
authors.lastname: Clarimon
authors.forename: A
authors.initials: A
authors.lastname: Lleo
authors.forename: A
authors.initials: A
authors.lastname: Bayer
authors.forename: D W
authors.initials: DW
authors.lastname: Tsuang
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Tsolaki
authors.forename: P
authors.initials: P
authors.lastname: Bossù
authors.forename: G
authors.initials: G
authors.lastname: Spalletta
authors.forename: P
authors.initials: P
authors.lastname: Proitsi
authors.forename: J
authors.initials: J
authors.lastname: Collinge
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
authors.forename: F
authors.initials: F
authors.lastname: Sanchez-Garcia
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: M C
authors.initials: MC
authors.lastname: Deniz Naranjo
authors.forename: P
authors.initials: P
authors.lastname: Bosco
authors.forename: R
authors.initials: R
authors.lastname: Clarke
authors.forename: C
authors.initials: C
authors.lastname: Brayne
authors.forename: D
authors.initials: D
authors.lastname: Galimberti
authors.forename: M
authors.initials: M
authors.lastname: Mancuso
authors.forename: F
authors.initials: F
authors.lastname: Matthews
authors.forename: S
authors.initials: S
authors.lastname: Moebus
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
authors.forename: M
authors.initials: M
authors.lastname: Del Zompo
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: H
authors.initials: H
authors.lastname: Hampel
authors.forename: A
authors.initials: A
authors.lastname: Pilotto
authors.forename: M
authors.initials: M
authors.lastname: Bullido
authors.forename: F
authors.initials: F
authors.lastname: Panza
authors.forename: P
authors.initials: P
authors.lastname: Caffarra
authors.forename: B
authors.initials: B
authors.lastname: Nacmias
authors.forename: J R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: M
authors.initials: M
authors.lastname: Mayhaus
authors.forename: L
authors.initials: L
authors.lastname: Lannefelt
authors.forename: H
authors.initials: H
authors.lastname: Hakonarson
authors.forename: S
authors.initials: S
authors.lastname: Pichler
authors.forename: M M
authors.initials: MM
authors.lastname: Carrasquillo
authors.forename: M
authors.initials: M
authors.lastname: Ingelsson
authors.forename: D
authors.initials: D
authors.lastname: Beekly
authors.forename: V
authors.initials: V
authors.lastname: Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Zou
authors.forename: O
authors.initials: O
authors.lastname: Valladares
authors.forename: S G
authors.initials: SG
authors.lastname: Younkin
authors.forename: E
authors.initials: E
authors.lastname: Coto
authors.forename: K L
authors.initials: KL
authors.lastname: Hamilton-Nelson
authors.forename: W
authors.initials: W
authors.lastname: Gu
authors.forename: C
authors.initials: C
authors.lastname: Razquin
authors.forename: P
authors.initials: P
authors.lastname: Pastor
authors.forename: I
authors.initials: I
authors.lastname: Mateo
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
authors.forename: K M
authors.initials: KM
authors.lastname: Faber
authors.forename: P V
authors.initials: PV
authors.lastname: Jonsson
authors.forename: O
authors.initials: O
authors.lastname: Combarros
authors.forename: M C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: L B
authors.initials: LB
authors.lastname: Cantwell
authors.forename: H
authors.initials: H
authors.lastname: Soininen
authors.forename: D
authors.initials: D
authors.lastname: Blacker
authors.forename: S
authors.initials: S
authors.lastname: Mead
authors.forename: T H
authors.initials: TH
authors.lastname: Mosley
authors.forename: D A
authors.initials: DA
authors.lastname: Bennett
authors.forename: T B
authors.initials: TB
authors.lastname: Harris
authors.forename: L
authors.initials: L
authors.lastname: Fratiglioni
authors.forename: C
authors.initials: C
authors.lastname: Holmes
authors.forename: R F
authors.initials: RF
authors.lastname: de Bruijn
authors.forename: P
authors.initials: P
authors.lastname: Passmore
authors.forename: T J
authors.initials: TJ
authors.lastname: Montine
authors.forename: K
authors.initials: K
authors.lastname: Bettens
authors.forename: J I
authors.initials: JI
authors.lastname: Rotter
authors.forename: A
authors.initials: A
authors.lastname: Brice
authors.forename: K
authors.initials: K
authors.lastname: Morgan
authors.forename: T M
authors.initials: TM
authors.lastname: Foroud
authors.forename: W A
authors.initials: WA
authors.lastname: Kukull
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
authors.forename: J F
authors.initials: JF
authors.lastname: Powell
authors.forename: M A
authors.initials: MA
authors.lastname: Nalls
authors.forename: K
authors.initials: K
authors.lastname: Ritchie
authors.forename: K L
authors.initials: KL
authors.lastname: Lunetta
authors.forename: J S
authors.initials: JS
authors.lastname: Kauwe
authors.forename: E
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: M
authors.initials: M
authors.lastname: Riemenschneider
authors.forename: M
authors.initials: M
authors.lastname: Boada
authors.forename: M
authors.initials: M
authors.lastname: Hiltuenen
authors.forename: E R
authors.initials: ER
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Rujescu
authors.forename: L S
authors.initials: LS
authors.lastname: Wang
authors.forename: J F
authors.initials: JF
authors.lastname: Dartigues
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
authors.forename: C
authors.initials: C
authors.lastname: Tzourio
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: C
authors.initials: C
authors.lastname: Graff
authors.forename: B M
authors.initials: BM
authors.lastname: Psaty
authors.forename: L
authors.initials: L
authors.lastname: Jones
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: P A
authors.initials: PA
authors.lastname: Holmans
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: L J
authors.initials: LJ
authors.lastname: Launer
authors.forename: L A
authors.initials: LA
authors.lastname: Farrer
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: V
authors.initials: V
authors.lastname: Moskvina
authors.forename: S
authors.initials: S
authors.lastname: Seshadri
authors.forename: J
authors.initials: J
authors.lastname: Williams
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide