title: Triggered Nanoparticles as Therapeutics.
abstract: Drug delivery systems (DDSs) face several challenges including site-specific delivery, stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with responsive moieties can enhance the efficacy of DDSs forin vitroandin vivosystems. This triggering process can be achieved through both endogenous (biologically controlled release) and exogenous (external stimuli controlled release) activation. In this review, we will highlight recent examples of the use of triggered release strategies of engineered nanomaterials forin vitroandin vivoapplications.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, MA 01003 USA.
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Kim
authors.forename: Bradley
authors.initials: B
authors.lastname: Duncan
authors.forename: Brian
authors.initials: B
authors.lastname: Creran
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
keywords: Engineered nanoparticles; drug delivery system; in vitro; in vivo; triggered release