title: [SOCS--suppressor of cytokine signaling proteins and their role in the pathogenesis of allergic and autoimmune disorders].
abstract: Cytokines play a major role in the innate and the adaptive immune responses. Since cytokines are very powerful messengers, several regulatory systems (in all levels: production, secretion, effect on target) control their action in order to prevent overstimulation of cytokines. Recently, a negative feedback of cytokine activity in the target cell, namely suppressor of cytokine signaling (SOCS) was defined. This regulatory system consist of 8 proteins (CIS.SOCS 1-7) n which each one of them specifically regulates one or more cytokines. Malfunction of the SOCS proteins may lead to unregulated activity of cytokines which may lead to the development of allergic and autoimmune disorders.
authors.affiliation: Department of Medicine B, Cinical Immunology, Allergy and AIDS Center, Kaplan Medical Center, Rehovot, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Mahlab-Guri
authors.forename: Ilan
authors.initials: I
authors.lastname: Asher
authors.forename: Zev
authors.initials: Z
authors.lastname: Sthoeger
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D050826:Suppressor of Cytokine Signaling Proteins / Q000276:immunology*; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D050826:Suppressor of Cytokine Signaling Proteins