title: Treatment of cystic macular lesions in hereditary retinal dystrophies.
abstract: Cystic macular lesions frequently contribute to impaired visual acuity in hereditary retinal dystrophies. Their pathogenesis varies and is not entirely understood. Carbonic anhydrase inhibitors have proven to be potentially efficacious, although not in all cases. We discuss the various factors and mechanisms implicated in the etiology of cystic macular lesions (anatomical abnormalities, impairment of the blood-retinal barrier, tangential vitreous traction, and mutations in retinoschin, etc.) and the various treatments that have been proposed.
authors.affiliation: Department of Ophthalmology, University La Sapienza, Italy; Pangere Center for Hereditary Retinal Diseases, The Chicago Lighthouse for People Who Are Blind or Visually Impaired, Chicago, Illinois, USA.
authors.forename: Serena
authors.initials: S
authors.lastname: Salvatore
authors.forename: Gerald A
authors.initials: GA
authors.lastname: Fishman
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Genead
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D015794:Choroideremia / Q000150:complications*; D015785:Eye Diseases, Hereditary / Q000150:complications*; D015799:Gyrate Atrophy / Q000150:complications*; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012162:Retinal Degeneration / Q000150:complications*; D012174:Retinitis Pigmentosa / Q000150:complications*; D041441:Retinoschisis / Q000150:complications*; D014786:Vision Disorders / Q000150:complications*
chemical_list: D002257:Carbonic Anhydrase Inhibitors
keywords: Goldmann-Favre syndrome; X-linked retinoschisis; choroideremia; cystoid macular lesions; enhanced S-cone syndrome; gyrate atrophy; hereditary retinal dystrophies; retinitis pigmentosa