title: [microRNA: new diagnostic and therapeutic tools in liver disease?].
abstract: microRNA are small non coding RNA, which negatively regulate the expression of their targets. Due to their various targets, miRNAs play a key role in number of physiological processes and in oncogenesis. The identification of specific miRNA signatures in various types of tumours, including hepatocellular carcinoma (HCC), highlights the dual role of miRNA, both oncogenes and tumour suppressors. Here, we review the current knowledge concerning the deregulation of miRNA expression in liver disease. All studies focusing on miRNAs argue for their possible use as diagnostic, prognostic and therapeutic markers. Here, we preferentially discuss the promising therapeutic strategies based on miRNAs that have been tested in HCC.
authors.affiliation: Inserm U1016, Institut Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France - université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: Angélique
authors.initials: A
authors.lastname: Gougelet
authors.forename: Sabine
authors.initials: S
authors.lastname: Colnot
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D025202:Molecular Diagnostic Techniques / Q000379:methods; D058990:Molecular Targeted Therapy / Q000379:methods; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs