title: Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats.
abstract: BACKGROUND
  Bryophyllum pinnatum Lam. used in folk medicine in tropical Africa, tropical America, India, China and Australia contains a wide range of active compounds, well known for their haemostatic and wound-healing properties.
  
  
  OBJECTIVE
  The present study was designed to evaluate the effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine (DENA)-induced hepatic injury in rats.
  
  
  METHODS
  The aerial part of B. pinnatum aqueous and ethanolic extract was prepared in doses of 250 mg/kg and 500 mg/kg. Hepatic injury was induced by DENA. Acute toxicity was also carried out.
  
  
  RESULTS
  Treatment with different doses of ethanolic extract of B. Pinnatum (250 mg/kg, p.o.) was not significantly able to treat the liver injury induced by DENA, but 500 mg/kg dose of ethanolic extract of B. Pinnatum protects the liver slightly. Treatment with different doses of aqueous extract of B. Pinnatum (250 and 500 mg/kg, p.o.) significantly (P*<0.05; P**<0.01 and P***<0.001) treated the liver injury induced by DENA.
  
  
  CONCLUSIONS
  It may be inferred from the present study that the hepatoprotective activities of the aqueous extract of B. Pinnatum leaves in DENA-induced hepatotoxicity may involve its antioxidant or oxidative free radical scavenging activities by alleviating lipid peroxidation through scavenging of free radicals, or by enhancing the activity of antioxidants.
authors.affiliation: Department of Pharmacology, Pacific University, Udaipur, Rajasthan, India ; Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Afzal
authors.forename: Imran
authors.initials: I
authors.lastname: Kazmi
authors.forename: Firoz
authors.initials: F
authors.lastname: Anwar
keywords: Bryophyllum pinnatum; N-diethylnitrosamine; histopathology; rats