title: The role of IL-33 in rheumatic diseases.
abstract: Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting Th2 type immune response, IL-33 plays important roles in the allergy, whereas its function in autoimmune diseases attracts more attention. Recent studies reported the correlation of IL-33 with rheumatic diseases, and most of them found that the IL-33 expression levels were consistent with disease activity and development. Furthermore, evidence has indicated that IL-33-related treatment may ameliorate the pathogenic conditions and attenuate disease progression of those rheumatic diseases. Therefore, elucidation of the roles of IL-33 in rheumatic diseases would be beneficial to understand the pathogenesis and therapy of these diseases. In this paper, we will summarize the roles of IL-33 in the rheumatic diseases.
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Duan
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Feili
authors.initials: F
authors.lastname: Gong
authors.forename: Guixiu
authors.initials: G
authors.lastname: Shi
mesh_terms: D000818:Animals; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000378:metabolism; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins; D017472:Receptors, Interleukin-1