title: The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis.
abstract: The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. Signaling pathway defects have long been hypothesized to participate in the pathology of psoriasis, yet their implication in the altered psoriatic gene expression still remains unclear. Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis. The data are still limited, though, for psoriatic arthritis. This review discusses the current data suggesting a crucial role for p38 MAPK in the pathogenesis of these disorders.
authors.affiliation: Cellular Immunotherapy and Molecular Immunodiagnostics, Institute of Research and Technology Thessaly, 41222 Larissa, Greece ; Division of Transplantation Immunology and Mucosal Biology, Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, Denmark Hill Campus, London SE5 9RS, UK.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Mavropoulos
authors.forename: Eirini I
authors.initials: EI
authors.lastname: Rigopoulou
authors.forename: Christos
authors.initials: C
authors.lastname: Liaskos
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Bogdanos
authors.forename: Lazaros I
authors.initials: LI
authors.lastname: Sakkas
mesh_terms: D056704:Adaptive Immunity; D015535:Arthritis, Psoriatic / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases