title: Novel function of STAT1 in breast cancer.
abstract: In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs). Inhibiting STAT1 activity offers a promising therapeutic approach against advanced breast cancer.
authors.affiliation: Departments of Molecular Pharmacology and Biological Chemistry; Northwestern University Feinberg School of Medicine; Chicago, IL, USA ; Robert H. Lurie Comprehensive Cancer Center; Northwestern University Feinberg School of Medicine; Chicago, IL, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
keywords: MDSCs; STAT1; T cell; breast cancer; immunosuppression