title: Phalangeal quantitative ultrasound: cheaper methods for screening and follow-up of bone pathologies in HIV-infected women?
abstract: This study estimated the prevalence of bone pathologies in a cohort of HIV-infected women in comparison with a cohort of HIV-negative women. Bone mineral density was measured by phalangeal quantitative ultrasound (AD-SoS: amplitude- dependent speed of sound; UBPI: ultrasound bone profile index). Risk of fracture, expressed by UBPI, was considered for value <0.39. Comparisons between groups and multivariate analyses were carried out using an ANOVA model. Correlations were evaluated using the Pearson correlation coefficient. Osteopenia and osteoporosis were present in 34.4% and 2% of patients, respectively. UBPI was pathologic in 5.7%. In a multivariate linear regression model significant correlations were found between AD-SoS z-score, duration of HIV-infection and BMI value. We also compared our cohort with 499 HIV-negative women as a historical control group of healthy subjects. AdSoS (2100 versus 2070 m/s) and UBPI (0.89 versus 0.74) were lower in HIV-infected women (p<0.001). Significant differences were also found in T-score values (p = 0.0013). These data show a high prevalence of bone diseases in women with HIV infection, correlated with duration of HIV-infection and BMI values. This non-invasive technique opens up new interesting perspectives, suggesting a possible use for bone mass screening in HIV-infected women.
authors.affiliation: Department of Internal Medicine and Infectious Diseases, IRCCS A.O.U. San Martino-IST, Genoa, Italy; 2Medical Office, IGEA s.r.l., Modena, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Prinapori
authors.forename: Rffaella
authors.initials: R
authors.lastname: Rosso
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
authors.forename: Laura
authors.initials: L
authors.lastname: Nicolini
authors.forename: Daniele Roberto
authors.initials: DR
authors.lastname: Giacobbe
authors.forename: Laura
authors.initials: L
authors.lastname: De Hoffer
authors.forename: Sara
authors.initials: S
authors.lastname: Grignolo
authors.forename: Francesca
authors.initials: F
authors.lastname: De Terlizzi
authors.forename: Marina
authors.initials: M
authors.lastname: Vignolo
authors.forename: Marco
authors.initials: M
authors.lastname: Borderi
authors.forename: Giulia
authors.initials: G
authors.lastname: Martelli
authors.forename: Leonardo
authors.initials: L
authors.lastname: Calza
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
authors.forename: Fabio
authors.initials: F
authors.lastname: Vescini
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D050278:Finger Phalanges / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D014463:Ultrasonography / Q000191:economics / Q000379:methods*; D055815:Young Adult