title: [Regulation of bone metabolisms by estrogen/estrogen receptors signaling].
abstract: Postmenopausal osteoporosis is caused by estrogen deficiency. The precise mechanism was unclear how estrogen maintains bone mass and how estrogen deficiency alters bone metabolism. However, the progress of generation and analyses of estrogen receptorα (ERα) conditional knockout mice have revealed the pathophysiology of postmenopausal osteoporosis. Here we introduce recent reports related to the estrogen/ERα mediated direct and indirect regulations in bone metabolism.
authors.affiliation: Division of Integrative Pathophysiology, Proteo-Science Center, Graduate School of Medicine, Ehime University, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000818:Animals; D015519:Bone Density / Q000235:genetics* / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D015195:Drug Design; D047628:Estrogen Receptor alpha / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000235:genetics; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D004967:Estrogens; D020845:Selective Estrogen Receptor Modulators