title: Slowing DNA translocation through a nanopore using a functionalized electrode.
abstract: Nanopores were fabricated with an integrated microscale Pd electrode coated with either a hydrogen-bonding or hydrophobic monolayer. Bare pores, or those coated with octanethiol, translocated single-stranded DNA with times of a few microseconds per base. Pores functionalized with 4(5)-(2-mercaptoethyl)-1H-imidazole-2-carboxamide slowed average translocation times, calculated as the duration of the event divided by the number of bases translocated, to about 100 μs per base at biases in the range of 50 to 80 mV.
authors.affiliation: Department of Physics, ‡Biodesign Institute, and §Department of Chemistry and Biochemistry, Arizona State University , Tempe, Arizona 85287, United States.
authors.forename: Padmini
authors.initials: P
authors.lastname: Krishnakumar
authors.forename: Brett
authors.initials: B
authors.lastname: Gyarfas
authors.forename: Weisi
authors.initials: W
authors.lastname: Song
authors.forename: Suman
authors.initials: S
authors.lastname: Sen
authors.forename: Peiming
authors.initials: P
authors.lastname: Zhang
authors.forename: Predrag
authors.initials: P
authors.lastname: Krstić
authors.forename: Stuart
authors.initials: S
authors.lastname: Lindsay
mesh_terms: D001692:Biological Transport; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D004566:Electrodes; D004867:Equipment Design; D006860:Hydrogen Bonding; D008422:Materials Testing; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods; D016011:Normal Distribution; D010165:Palladium / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors
chemical_list: D004277:DNA, Single-Stranded; D008567:Membranes, Artificial; D013438:Sulfhydryl Compounds; D010165:Palladium; D004247:DNA