title: Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation.
abstract: BACKGROUND
  Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases.
  
  
  OBJECTIVE
  The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC.
  
  
  METHODS
  The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out.
  
  
  RESULTS
  Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001).
  
  
  CONCLUSIONS
  From the above results, it has been justified that SPC can be used to treat allergic disorders.
authors.affiliation: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India.
authors.forename: Inder K
authors.initials: IK
authors.lastname: Makhija
authors.forename: Chandrashekara S
authors.initials: CS
authors.lastname: Shreedhara
authors.forename: H N Aswatha
authors.initials: HN
authors.lastname: Ram
keywords: Compound 48/80; Sitopaladi churna; mast cell stabilizing