title: Latent abnormal pathology affects long-term graft function in elder living renal allograft recipients.
abstract: OBJECTIVE
  This study evaluated the long-term effects and clinical significance of latent abnormal pathology on elder living donor kidney graft function after renal transplantation in China.
  
  
  METHODS
  One-hundred and thirty-eight living donor renal transplantations have been carried out at our hospital in recent years. Of these, 72 Time-Zero biopsies were performed and used in this analysis. Clinical data were retrospectively measured at 3, 6, 12, and 24 months after renal transplants. Relationships and effects from biopsy results taken from implanted donor kidney grafts were analyzed.
  
  
  RESULTS
  Time-Zero biopsy pathology results from donor kidneys showed that 48.61% of donor kidneys had latent abnormal changes; arterial lesions of donor kidneys had significant effects on the renal function of grafts after 2 years' transplantation; correlations between donor age and arterial lesions were significant; and Time-Zero biopsy pathology results could help predict the long-term function of a renal graft.
  
  
  CONCLUSIONS
  Existing latent pathological changes of an elder living donor kidney before transplantation could affect long-term renal function. Whether a senior donor is used should be very carefully considered.
authors.affiliation: Urology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Du
authors.forename: Zelin
authors.initials: Z
authors.lastname: Xie
authors.forename: Yawang
authors.initials: Y
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.forename: Hongbo
authors.initials: H
authors.lastname: Guo
authors.forename: Rumei
authors.initials: R
authors.lastname: Bi
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Zhang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhu
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000328:Adult; D000367:Age Factors; D064591:Allografts / Q000473:pathology* / Q000503:physiopathology*; D001706:Biopsy; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents