title: Metabolic syndrome components can predict C reactive protein concentration in adolescents.
abstract: BACKGROUND
  Metabolic syndrome (MS) is suggested to be associated with a low grade inflammation state, but the relationship between inflammation biomarkers and the components of metabolic syndrome in adolescents are still lacking.
  
  
  OBJECTIVE
  To investigate the association between C-reactive protein (CRP) serum concentrations and metabolic syndrome components in adolescents.
  
  
  METHODS
  A cross-sectional population based study was conducted. Anthropometric, biochemical and clinical data were collected from 524 adolescents (11-15 years old) randomly sampled from school population of Alegre city, Espírito Santo, Brazil. Data were analyzed by STATA version 9.0.
  
  
  RESULTS
  Adolescents with higher values for BMI (p = 0.001) and higher body fat percentage (p = 0.003) had higher CRP concentrations than those with lower BMI and body fat percentage. CRP concentrations was directly correlated with BMI (r = 0.17, p = 0.0001), waist circumference (r = 0.15, p = 0.0005), HDL-c (r = 0.13, p = 0.003), fasting insulin (r = 0.12, p = 0.003) and systolic blood pressure (r = 0.11, p with = 0.01). In the multiple linear regression analysis BMI (r = 0.05, p = 0.002), fasting glucose (r = -0.01, p = 0.003) and HDL-c (r = 0.017, p < 0.001) were associated to CRP concentrations after adjusting for the other components of MS.
  
  
  CONCLUSIONS
  The association found between individual components of MS and CRP concentrations suggests that inflammation might be an early event in the development of metabolic disorders in adolescents.
authors.affiliation: School of Nutrition and 3NUPEB. Federal University of Ouro Preto. Ouro Preto. Minas Gerais. Brazil.
authors.forename: Larissa Leandro
authors.initials: LL
authors.lastname: da Cruz
authors.forename: Luciane Daniele
authors.initials: LD
authors.lastname: Cardoso
authors.forename: Daniela
authors.initials: D
authors.lastname: Pala
authors.forename: Heberth
authors.initials: H
authors.lastname: de Paula
authors.forename: Joel Alves
authors.initials: JA
authors.lastname: Lamounier
authors.forename: Camilo Adalton Mariano
authors.initials: CA
authors.lastname: Silva
authors.forename: Ana Carolina Pinheiro
authors.initials: AC
authors.lastname: Volp
authors.forename: Renata Nascimento
authors.initials: RN
authors.lastname: de Freitas
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D050218:Body Fat Distribution; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein