title: Synthesis of 2,8-dioxabicyclo[3.3.1]nonane derivatives via a sequential Knoevenagel condensation and hetero-Diels-Alder reaction in an aqueous medium.
abstract: Utilizing aldehyde-substituted vinylogous carbonates and 1,3-diketones, a simple protocol is presented for the synthesis of 2,8-dioxabicyclo[3.3.1]nonane derivatives via Knoevenagel condensation followed by a hetero-Diels-Alder reaction under green reaction conditions. The structure of a key product is unequivocally confirmed by X-ray crystallography.
authors.affiliation: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Venu
authors.initials: V
authors.lastname: Srinivas
authors.forename: Mamoru
authors.initials: M
authors.lastname: Koketsu