title: [Serological characteristics and transfusion efficacy evaluation in 61 cases of autoimmune hemolytic anemia].
abstract: This study was aimed to analyze the serological characteristics, efficacy and safety of incompatible RBC transfusion in patients with autoimmune hemolytic anemia (AIHA). The patients with idiopathic or secondary AIHA were analyzed retrospectively, then the serological characteristics and the incidence of adverse transfusion reactions were investigated, and the efficacy and safety of incompatible RBC transfusion were evaluated according to the different autoantibody type and infused different RBC components. The results showed that out of 61 cases of AIHA, 21 cases were idiopathic, and 40 cases were secondary. 8 cases (13.1%) had IgM cold autoantibody, 50 cases (82.0%) had IgG warm autoantibody, and 3 cases (4.9%) had IgM and IgG autoantibodies simultaneously. There were 18 cases (29.5%) combined with alloantibodies. After the exclusion of alloantibodies interference, 113 incompatible RBC transfusions were performed for 36 patients with AIHA, total efficiency rate, total partial efficiency rate and total inefficiency rate were 56.6%, 15.1% and 28.3%, respectively. Incompatible RBC transfusions were divided into non-washed RBC group and washed RBC group. The efficiency rate, partial efficiency rate and inefficiency rate in non-washed RBC group were 57.6%, 13.0% and 29.4%, respectively. The efficiency rate, partial efficiency rate and inefficiency rate in washed RBC group were 53.6%, 21.4% and 25.0%, respectively. There was no significant difference of transfusion efficacy (P > 0.05) in two groups. Incompatible RBC transfusions were also divided into IgM cold autoantibody group and IgG warm autoantibody group. The efficiency rate, partial efficiency rate and inefficiency rate in IgM cold autoantibody group were 46.2%, 30.8% and 29.4%, respectively. The efficiency rate, partial efficiency rate and inefficiency rate in IgG warm autoantibody group were 56.7%, 13.4% and 29.9%, respectively. There was no significant difference of transfusion efficacy (P > 0.05 ) in two groups. Hemolytic transfusion reaction was not observed in all incompatible RBC transfusions. It is concluded that the same ABO type of non-washed RBC transfusion and O type washed RBC transfusion are all relatively safe for the AIHA patients with severe anemia after the exclusion of alloantibodies interference. There is no significant difference of transfusion efficacy in two groups. The same ABO type of non-washed RBC transfusion is more convenient and efficient than washed RBC transfusion, and excessive use of type O RBCs can also be avoided.
authors.affiliation: Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital,Beijing 100853, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Sun
authors.forename: Chun-Ya
authors.initials: CY
authors.lastname: Ma
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Guan
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Lin-Fen
authors.initials: LF
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Li
authors.forename: Yan-Nan
authors.initials: YN
authors.lastname: Feng
authors.forename: Shan
authors.initials: S
authors.lastname: Tong
authors.forename: Shuai
authors.initials: S
authors.lastname: Yu
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Pan
authors.forename: Qian
authors.initials: Q
authors.lastname: Fen
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: De-Qing
authors.initials: DQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D001788:Blood Grouping and Crossmatching; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007518:Isoantibodies; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007518:Isoantibodies