title: Corneal mineralization in wistar hannover rats.
abstract: We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa's method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Wako
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.forename: Sou
authors.initials: S
authors.lastname: Wada
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
keywords: Background data; Cornea; Keratocyte; Mineralization; Wistar Hannover rat