title: Deaminative and decarboxylative catalytic alkylation of amino acids with ketones.
abstract: It cuts two ways: The cationic [Ru-H] complex catalyzes selective coupling of α- and β-amino acids with ketones to form α-alkylated ketone products. The reaction involves CC and CN bond cleavage which result in regio- and stereoselective alkylation using amino acids. A broad substrate scope and high functional-group tolerance is demonstrated.
authors.affiliation: Department of Chemistry, Marquette University, Milwaukee, WI 53201-1881 (USA).
authors.forename: Nishantha
authors.initials: N
authors.lastname: Kalutharage
authors.forename: Chae S
authors.initials: CS
authors.lastname: Yi
mesh_terms: D000478:Alkylation; D000596:Amino Acids; D002384:Catalysis; D003641:Deamination; D007659:Ketones / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007659:Ketones; D012428:Ruthenium
keywords: alkylation; amino acids; ketones; ruthenium; synthetic methods