title: Inhibition of miRNA maturation by peptide nucleic acids.
abstract: Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
authors.affiliation: Dipartimento delle Scienze Biologiche, Università di Napoli "Federico II", Napoli, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Avitabile
authors.forename: Enrica
authors.initials: E
authors.lastname: Fabbri
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bianchi
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Alessandra
authors.initials: A
authors.lastname: Romanelli
mesh_terms: D015195:Drug Design; D005449:Fluorenes / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D006801:Humans; D020014:K562 Cells; D035683:MicroRNAs / Q000302:isolation & purification / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012322:RNA Precursors / Q000302:isolation & purification / Q000378:metabolism
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D005449:Fluorenes; D035683:MicroRNAs; D020135:Peptide Nucleic Acids; D012322:RNA Precursors; D016650:Fluorescein-5-isothiocyanate