title: Complete nucleotide sequences of virulence-resistance plasmids carried by emerging multidrug-resistant Salmonella enterica Serovar Typhimurium isolated from cattle in Hokkaido, Japan.
abstract: In the present study, we have shown that virulence-resistance plasmids from emerging multidrug-resistant isolates of Salmonella enterica serovar Typhimurium were derived from a virulence-associated plasmid, essential for systematic invasiveness of S. Typhimurium in mice (pSLT), through acquisition of a large insert containing a resistance island flanked by IS1294 elements. A bla CMY-2-carrying plasmid from a cefotaxime-resistant isolate comprised a segment of Escherichia coli plasmid pAR060302 and the replication region (IncFIB) of a virulence-resistance plasmid. These results provide insights into the evolution of drug resistance in emerging clones of S. Typhimurium.
authors.affiliation: Hokkaido Research Station, National Institute of Animal Health, Sapporo, Hokkaido, Japan.
authors.forename: Yukino
authors.initials: Y
authors.lastname: Tamamura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Masato
authors.initials: M
authors.lastname: Akiba
authors.forename: Toru
authors.initials: T
authors.lastname: Kanno
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hatama
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishihara
authors.forename: Ikuo
authors.initials: I
authors.lastname: Uchida
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D007564:Japan; D051379:Mice; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics* / Q000302:isolation & purification*; D014774:Virulence / Q000235:genetics*