title: Analysis report for osteosarcoma expression profile.
abstract: BACKGROUND
  Osteosarcoma is a kind of highly malignant primary bone tumor which most common in the teenage, and holds strong aggressive, earlier organs metastases mainly to lung, prone to postoperative recur. Therefore for osteosarcoma, invasion and transfer mechanism and related factors' interaction remains to be a key research subject.
  
  
  OBJECTIVE
  We aim to find biological molecules marker can be used for osteosarcoma diagnosis through contrast of osteosarcoma sample and normal tissue samples.
  
  
  METHODS
  This analysis using human osteosarcoma expression profile data and three lesions normal tissue samples (liver, kidneys, lymph) expression data and compare them, and find significant specifically expressed genes, according to their function.
  
  
  RESULTS
  Research shows that the cancer cell proliferation, invasion, transfer and recurrent process involve many factors interaction, of which angiogenesis is the necessary condition of tumor growth, transfer and the recurrence.
  
  
  CONCLUSIONS
  Now the most important positive regulatory factor of angiogenesis is VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor). Both of them are with a wide variety and close relationship of tumor angiogenesis and progress.
authors.affiliation: Department of Orthopedics, Changhai  Hospital, Second Military Medical University, Shanghai, China. mlzhwwang@hotmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Zhan
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Fu
authors.forename: X D
authors.initials: XD
authors.lastname: Zhu
authors.forename: D W
authors.initials: DW
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: Z W
authors.initials: ZW
authors.lastname: Wang
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics*; D003094:Collagen / Q000235:genetics; D018031:Connexin 43 / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D012516:Osteosarcoma / Q000235:genetics*; D059467:Transcriptome
chemical_list: D018031:Connexin 43; C500216:GJA1 protein, human; D003094:Collagen