title: Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide.
abstract: Extended X-ray absorption fine structure spectroscopy, mass spectrometry, dynamic light scattering and density functional theory are combined to derive structural models for the interaction of neurotoxicity-ablating platinum-based compounds with the amyloid-β peptide.
authors.affiliation: CSIRO Materials Science & Engineering and Preventative-Health Flagship, Parkville, Victoria 3052, Australia. Victor.Streltsov@csiro.au.
authors.forename: Victor A
authors.initials: VA
authors.lastname: Streltsov
authors.forename: V
authors.initials: V
authors.lastname: Chandana Epa
authors.forename: Simon A
authors.initials: SA
authors.lastname: James
authors.forename: Quentin I
authors.initials: QI
authors.lastname: Churches
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Caine
authors.forename: Vijaya B
authors.initials: VB
authors.lastname: Kenche
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Barnham
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008027:Light; D010618:Phenanthrolines / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*; D011485:Protein Binding; D012542:Scattering, Radiation; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D010618:Phenanthrolines; D010984:Platinum; C025205:1,10-phenanthroline