title: The threshold of cortical electrical stimulation for mapping sensory and motor functional areas.
abstract: This study aimed to investigate the threshold of cortical electrical stimulation (CES) for functional brain mapping during surgery for the treatment of rolandic epilepsy. A total of 21 patients with rolandic epilepsy who underwent surgical treatment at the Beijing Institute of Functional Neurosurgery between October 2006 and March 2008 were included in this study. Their clinical data were retrospectively collected and analyzed. The thresholds of CES for motor response, sensory response, and after discharge production along with other threshold-related factors were investigated. The thresholds (mean ± standard deviation) for motor response, sensory response, and after discharge production were 3.48 ± 0.87, 3.86 ± 1.31, and 4.84 ± 1.38 mA, respectively. The threshold for after discharge production was significantly higher than those of both the motor and sensory response (both p<0.05). A negative linear correlation was found between the threshold of after discharge production and disease duration. Using the CES parameters at a stimulation frequency of 50 Hz and a pulse width of 0.2 ms, the threshold of sensory and motor responses were similar, and the threshold of after discharge production was higher than that of sensory and motor response.
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China. Electronic address: zgj62051@163.com.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Guojun
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Ni
authors.initials: N
authors.lastname: Duanyu
authors.affiliation: Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Fu
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Cai
authors.initials: C
authors.lastname: Lixin
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Du
authors.initials: D
authors.lastname: Wei
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liang
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Xuanwu District, Beijing 100053, People's Republic of China.
authors.forename: Ren
authors.initials: R
authors.lastname: Zhiwei
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology* / Q000601:surgery; D004558:Electric Stimulation / Q000379:methods*; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D058542:Implantable Neurostimulators; D016014:Linear Models; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010465:Perception / Q000502:physiology*; D011379:Prognosis; D012189:Retrospective Studies; D012677:Sensation; D012684:Sensory Thresholds; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cortex functional mapping; Cortical electrical stimulation; Perirolandic epilepsy; Sensor and motor cortex; Stimulation threshold