title: New phenanthrene glycosides from Dioscorea opposita.
abstract: Two new phenanthrene glycosides, dioscopposide A and dioscopposide B (1 and 2), were isolated from the rhizomes of Dioscorea opposita. Their structures were determined primarily on the basis of 1D and 2D NMR techniques, MS studies, and chemical methods. All the isolates were evaluated for their inhibitory effects on the lipopolysaccharide-induced nitric oxide production using murine macrophage RAW 264.7 cells. The IC50 values of dioscopposide A and dioscopposide B were 5.8 and 7.2 μM, respectively.
authors.affiliation: a The School of Life Science, Sun Yat-Sen University , Guangzhou , 510275 , China.
authors.forename: Ken Yu-Zhong
authors.initials: KY
authors.lastname: Zheng
authors.forename: Zhen-Xia
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Wenliang
authors.initials: W
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Fei-Jun
authors.initials: FJ
authors.lastname: Xiang
mesh_terms: D000818:Animals; D027742:Dioscorea / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D008070:Lipopolysaccharides; D010616:Phenanthrenes; C587114:dioscopposide A; C587115:dioscopposide B; D009569:Nitric Oxide