title: Natural killer T (NKT) cells in autoimmune hepatitis.
abstract: Natural killer T (NKT) cells represent an innate-like lymphocyte population endowed with unique antigen recognition and tissue distribution features. Their abundance in the microvascular compartments of the liver allows NKT cells to immediately respond to lipid antigens and soluble factors circulating through the portal vein system by releasing tremendous amounts of different cytokines and chemokines. Subsequently, dependent on the nature of the lipid antigen encountered as well as the accessory signal(s) provided, NKT cells not only contribute to the maintenance of immune tolerance, but also direct adverse immune reactions locally and systemically. Focusing on their potent immunomodulatory features and their interactions with various innate and adaptive immune cells, the role of NKT cells in perpetuating the loss of liver-specific immune tolerance will be discussed.
authors.affiliation: Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany; Division of Cellular and Molecular Immunology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA. Electronic address: Jochen.Mattner@uk-erlangen.de.
authors.forename: Jochen
authors.initials: J
authors.lastname: Mattner
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D055611:Natural Killer T-Cells / Q000276:immunology*