title: Source attribution of human campylobacteriosis in Denmark.
abstract: SUMMARY This study assesses the contribution of different sources of human campylobacteriosis in Denmark using two different source-attribution approaches. In total, 794 non-human isolates and 406 isolates from human cases (domestic, travel related, and cases with unknown travel history) were collected. Isolates were characterized by multilocus sequence typing, flaA typing and susceptibility to antibiotics. Both models used indicate that the major burden of human campylobacteriosis in Denmark originates from the domestic broiler chicken reservoir. The second most important reservoir was found to be cattle. The Asymmetric Island model attributed 52% [95% credibility interval (CrI) 37-67] to Danish chicken, 17% (95% CrI 3-33) to imported chicken, and 17% (95% CrI 7-28) to cattle. Similarly, the Campylobacter source-attribution model apportioned 38% (95% CrI 28-47) to Danish chicken, 14% (95% CrI 10-18) to imported chicken, and 16% (95% CrI 7-25) to cattle. The addition of flaA type as an extra discriminatory typing parameter did not change the attribution of cases markedly.
authors.affiliation: Technical University of Denmark,National Food Institute, Division of Epidemiology and Microbial Genomics, Soeborg,Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Boysen
authors.affiliation: Technical University of Denmark,National Food Institute, Division of Epidemiology and Microbial Genomics, Soeborg,Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Rosenquist
authors.affiliation: Statens Serum Institut, Food-borne Pathogens and Typing,Department of Public Health Microbiology, Copenhagen,Denmark.
authors.forename: J T
authors.initials: JT
authors.lastname: Larsson
authors.affiliation: Statens Serum Institut, Food-borne Pathogens and Typing,Department of Public Health Microbiology, Copenhagen,Denmark.
authors.forename: E M
authors.initials: EM
authors.lastname: Nielsen
authors.affiliation: Technical University of Denmark,National Food Institute, Division of Epidemiology and Microbial Genomics, Soeborg,Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Sørensen
authors.affiliation: Technical University of Denmark,National Food Institute, Division of Microbial Food Safety, Soeborg,Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Nordentoft
authors.affiliation: Technical University of Denmark,National Food Institute, Division of Epidemiology and Microbial Genomics, Soeborg,Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Hald
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002167:Campylobacter / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002169:Campylobacter Infections / Q000453:epidemiology* / Q000662:veterinary*; D002417:Cattle; D002645:Chickens; D003718:Denmark / Q000453:epidemiology; D004197:Disease Reservoirs; D005408:Flagellin / Q000235:genetics; D005517:Foodborne Diseases / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing
chemical_list: D000900:Anti-Bacterial Agents; D005408:Flagellin; C067138:flaA protein, bacteria