title: Obesity negatively impacts lung function in children and adolescents.
abstract: OBJECTIVE
  To investigate the relationship between weight status (body mass index [BMI] percentile and BMI z-score) and lung volumes in healthy children and adolescents.
  
  
  OBJECTIVE
  We hypothesized that: (a) there would be a significant inverse relationship between age- and sex-specific BMI distribution and functional residual capacity (FRC), and expiratory reserve volume (ERV), respectively; and (b) obese children would have significantly reduced FRC and ERV compared to their non-obese peers.
  
  
  METHODS
  The medical records of all individuals who successfully performed pulmonary function testing between 2000 and 2007 at two university children's hospitals were reviewed. Participants were excluded if they had cardiopulmonary, neuromuscular, or chest wall disease.
  
  
  RESULTS
  Of 1,469 record reviewed, 327 subjects met study criteria. Percent predicted ERV was lowest in the obese group (P < 0.001) while residual volume (RV) was lowest in the overweight and obese groups (P < 0.001). Underweight participants had a lower percent predicted forced vital capacity (FVC) (P = 0.027) and vital capacity (VC; P = 0.039). Obese participants had the lowest FEV1 /FVC (P < 0.001). A positive linear relationship existed between BMI z-score and percent predicted FVC, VC, and diffusing capacity of carbon monoxide (DLCO ). A negative linear relationship was found between BMI z-score and percent predicted FRC, ERV, RV, and absolute FEV1 /FVC.
  
  
  CONCLUSIONS
  Our results show that increasing weight status in children and adolescents is associated with a general reduction in lung volume measurements, which may reflect impaired lung function, increased respiratory symptoms, and decreased functional status.
authors.affiliation: Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Davidson
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Mackenzie-Rife
authors.forename: Manisha B
authors.initials: MB
authors.lastname: Witmans
authors.forename: Mark D
authors.initials: MD
authors.lastname: Montgomery
authors.forename: Geoff D C
authors.initials: GD
authors.lastname: Ball
authors.forename: Shirley
authors.initials: S
authors.lastname: Egbogah
authors.forename: Neil D
authors.initials: ND
authors.lastname: Eves
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000150:complications*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013851:Thinness
keywords: body weight; pulmonary function tests; youth