title: Prooxidant-antioxidant balance and cardiac function in patients with cardiovascular disease following cardiac surgery.
abstract: OBJECTIVE
  Cardiopulmonary bypass (CPB) is used during on-pump coronary artery bypass grafting (CABG) and heart valvular replacement surgery, and is associated with the induction of oxidative stress. The aim of the study was to assess the association between indices of cardiac function and prooxidant-antioxidant balance (PAB) values in patients undergoing valve replacement surgery and on-or off-pump CABG.
  
  
  METHODS
  Data were obtained from 44, 33, and 41 patients undergoing off-pump CABG, on-pump CABG, and valve replacement surgery, respectively. The PAB values were measured 24 h before and after the operative procedure, and at the time of discharge. Echocardiography was performed before surgery and before discharge.
  
  
  RESULTS
  The changes in E/E', end-diastolic volume, end-systolic volume, left ventricular diastolic and systolic diameter were significantly related to baseline PAB values. In the valve replacement group, neither baseline nor changes in PAB values were associated with echocardiographic measurements. Also, neither off-pump nor on-pump CABG were significantly different in inducing oxidative stress (p = 0.596). When PAB values were measured in CABG patients, there was a significant difference in values between the three time points (p = 0.013). In the valve replacement group, PAB values were not significantly different between the preoperative and postoperative samples.
  
  
  CONCLUSIONS
  The inverse association between the level of oxidative stress and cardiac function measurement may indicate that high levels of oxidative stress may be a predictor of the deterioration of cardiac function in CABG patients. However, in valvular heart disease patients the serum PAB value was not associated with changes in cardiac function. Levels of oxidative stress, as assessed by the PAB assay, were not significantly different for patients undergoing surgery with or without CPB.
authors.affiliation: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Rahsepar
authors.forename: Asadollah
authors.initials: A
authors.lastname: Mirzaee
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moodi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Khorashadizadeh
authors.forename: Behrooz
authors.initials: B
authors.lastname: Mottahedi
authors.forename: Jamil
authors.initials: J
authors.lastname: Esfehanizadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Azari
authors.forename: Mostafa
authors.initials: M
authors.lastname: Sajjadian
authors.forename: Roshanak
authors.initials: R
authors.lastname: Khojasteh
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Paydar
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mousavi
authors.forename: Maral
authors.initials: M
authors.lastname: Amini
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D001560:Benzidines; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000601:surgery; D002863:Chromogenic Compounds; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods; D005260:Female; D006334:Heart Function Tests / Q000379:methods; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D011182:Postoperative Care; D011300:Preoperative Care; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D001560:Benzidines; D002863:Chromogenic Compounds; D016877:Oxidants; C021758:3,3',5,5'-tetramethylbenzidine