title: Role of developmental overnutrition in pediatric obesity and type 2 diabetes.
abstract: Childhood obesity continues to be a significant public health burden. Empirical evidence has begun to identify intrauterine and postnatal pathways that increase the likelihood of excess adiposity and increased risk of type 2 diabetes among offspring. Reviewed here is the evidence supporting a transgenerational vicious cycle that increases obesity and diabetes in offspring and contributes substantially to the increases in obesity and type 2 diabetes observed over the past several decades. The public health impact of these findings is discussed and future research opportunities are outlined.
authors.affiliation: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Dabelea
authors.forename: Curtis S
authors.initials: CS
authors.lastname: Harrod
mesh_terms: D050154:Adiposity / Q000502:physiology; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008137:Longitudinal Studies; D044343:Overnutrition / Q000150:complications*; D063766:Pediatric Obesity / Q000453:epidemiology / Q000209:etiology*; D011634:Public Health
keywords: childhood obesity; developmental overnutrition; pediatrics; type 2 diabetes