title: Regulating angiogenesis with light-inducible AntimiRs.
abstract: The inhibition of microRNAs (miRs) in a spatiotemporally defined manner by an exogenous trigger would help to specifically target the biological activity and avoid off-target effects. Novel antimiRs directed against miR-92a can be activated by irradiation (see scheme; 3'-UTR=3'-untranslated region) In this way miR-92a is inhibited, the miR-92a target integrin α5 is derepressed, and angiogenesis of endothelial cells is enhanced.
authors.affiliation: Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany).
authors.forename: Florian
authors.initials: F
authors.lastname: Schäfer
authors.forename: Jasmin
authors.initials: J
authors.lastname: Wagner
authors.forename: Andrea
authors.initials: A
authors.lastname: Knau
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dimmeler
authors.forename: Alexander
authors.initials: A
authors.lastname: Heckel
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009389:Neovascularization, Pathologic; D010782:Photolysis
chemical_list: D035683:MicroRNAs
keywords: RNA; angiogenesis; antimiR; photolysis