title: The role of gingival melanin pigmentation in inflammation of gingiva, based on genetic analysis.
abstract: BACKGROUND
  Aim of the study was to investigate the relationship of melanin pigment and inflammatory process within gingival tissues based on clinical and genetic analysis by differential display technique and DNA sequencing.
  
  
  METHODS
  Seventy gingival biopsy specimens were taken from individuals with melanin pigmentation as well as healthy and inflamed gingiva. Specimens were examined by differential display technique using six different arbitrary primers. Cloning, sequencing and sequence analysis for six different genes were performed.
  
  
  RESULTS
  Gingival specimens with hyperpigmentation (clinical melanin score = 3) showed presence of both, down- and up-regulatory genes when compared with the gingival specimen with clinical melanin score 0. These genes may have a role in curtailing the progress of gingival inflammation associated with melanin hyperpigmentation.
  
  
  CONCLUSIONS
  Melanin hyper pigmentation may possess a defensive role against progress of gingival inflammation How to cite this article:Eid HA, Syed S, Soliman AN. The Role of Gingival Melanin Pigmentation in Inflammation of Gingiva, Based on Genetic Analysis. J Int Oral Health 2013; 5(4):1-7.
authors.affiliation: Department of Oral medicine & Periodontology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt, Department of Preventive Dental Sciences, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.
authors.forename: Hossam A
authors.initials: HA
authors.lastname: Eid
authors.forename: Sadatullah
authors.initials: S
authors.lastname: Syed
authors.forename: Abdel Nasser Mm
authors.initials: AN
authors.lastname: Soliman
keywords: Differential display technique; Gingiva; Melanin hyper pigmentation