title: Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment.
abstract: In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.
authors.affiliation: 1Department of Pharmacy, 302 Military Hospital of China, Beijing, China.
authors.forename: He
authors.initials: H
authors.lastname: Xu
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Yuan
authors.forename: Bao-De
authors.initials: BD
authors.lastname: Shen
authors.forename: Jin
authors.initials: J
authors.lastname: Han
authors.forename: Qing-Yuan
authors.initials: QY
authors.lastname: Lv
authors.forename: Ling
authors.initials: L
authors.lastname: Dai
authors.forename: Ming-Gui
authors.initials: MG
authors.lastname: Lin
authors.forename: Chao
authors.initials: C
authors.lastname: Yu
authors.forename: Jin-Xia
authors.initials: JX
authors.lastname: Bai
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yuan
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry*; D001599:Berberine / Q000008:administration & dosage*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels; D007239:Infections / Q000209:etiology / Q000628:therapy*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014947:Wounds and Injuries / Q000150:complications / Q000628:therapy*
chemical_list: D000180:Acrylic Resins; D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D001599:Berberine; C052970:poly-N-isopropylacrylamide; D020723:Glucuronic Acid
keywords: Hydrogel; berberine; hydrogel-grafted fabrics; nanosuspension; poly(N-isopropylacrylamide); wound dressing