title: Memory impairment is associated with serum methylarginines in older adults.
abstract: BACKGROUND
  This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.
  
  
  METHODS
  Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).
  
  
  RESULTS
  Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.
  
  
  CONCLUSIONS
  Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.
authors.forename: Mark
authors.initials: M
authors.lastname: McEvoy
authors.forename: Peter
authors.initials: P
authors.lastname: Schofield
authors.forename: Wayne
authors.initials: W
authors.lastname: Smith
authors.forename: Kingsley
authors.initials: K
authors.lastname: Agho
authors.forename: Arduino A
authors.initials: AA
authors.lastname: Mangoni
authors.forename: Roy L
authors.initials: RL
authors.lastname: Soiza
authors.forename: Roseanne
authors.initials: R
authors.lastname: Peel
authors.affiliation: Level 4 Hunter Medical Research Institute, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308 Australia. john.attia@newcastle.edu.au.
authors.forename: John
authors.initials: J
authors.lastname: Attia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001281:Atrial Fibrillation / Q000453:epidemiology; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D004522:Educational Status; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008569:Memory Disorders / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D016017:Odds Ratio; D012720:Severity of Illness Index
chemical_list: C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine