title: Longitudinal trajectory of sexual functioning after hematopoietic cell transplantation: impact of chronic graft-versus-host disease and total body irradiation.
abstract: This prospective study described the trajectory of sexual well-being from before hematopoietic cell transplantation (HCT) to 3 years after in 131 allogeneic and 146 autologous HCT recipients using Derogatis Interview for Sexual Function and Derogatis Global Sexual Satisfaction Index. Sixty-one percent of men and 37% of women were sexually active pre-HCT; the prevalence declined to 51% (P = .01) in men and increased to 48% (P = .02) in women at 3 years post-HCT. After HCT, sexual satisfaction declined in both sexes (P < .001). All sexual function domains were worse in women compared with men (P ≤ .001). Orgasm (P = .002) and drive/relationship (P < .001) declined in men, but sexual cognition/fantasy (P = .01) and sexual behavior/experience (P = .01) improved in women. Older age negatively impacted sexual function post-HCT in both sexes (P < .01). Chronic graft-versus-host disease was associated with lower sexual cognition/fantasy (P = .003) and orgasm (P = .006) in men and sexual arousal (P = .05) and sexual satisfaction (P = .005) in women. All male sexual function domains declined after total body irradiation (P < .05). This study identifies vulnerable subpopulations that could benefit from interventional strategies to improve sexual well-being.
authors.affiliation: Population Sciences.
authors.forename: F Lennie
authors.initials: FL
authors.lastname: Wong
authors.forename: Liton
authors.initials: L
authors.lastname: Francisco
authors.forename: Kayo
authors.initials: K
authors.lastname: Togawa
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Alysia
authors.initials: A
authors.lastname: Bosworth
authors.forename: Liezl
authors.initials: L
authors.lastname: Atencio
authors.forename: Cara
authors.initials: C
authors.lastname: Hanby
authors.forename: Marcia
authors.initials: M
authors.lastname: Grant
authors.forename: Fouad
authors.initials: F
authors.lastname: Kandeel
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000503:physiopathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D012725:Sexual Behavior / Q000502:physiology* / Q000528:radiation effects; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*