title: Modern spectroscopic technique in the characterization of biosensitive macrocyclic Schiff base ligand and its complexes: inhibitory activity against plantpathogenic fungi.
abstract: Complexes of the type [M(L)Cl2], where M = Co(II), Ni(II) and Cu(II) have been synthesized with a macrocyclic Schiff base ligand (1,4,5,7,10,11,12,15-octaaza,5,11,16,18-tetraphenyl, 3,4,12,13-tetramethyl cyclo-octadecane) derived from Schiff base (obtained by the condensation of 4-aminoantipyrine and dibenzoyl methane) and ethylenediamine. The ligand was characterized on the basis of elemental analysis, IR, (1)H NMR, EI Mass and molecular modeling studies while the complexes were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR, electronic and EPR spectral studies. All the complexes are non-electrolyte in nature. The covalency factor (β) and coefficient factor (α) suggest the covalent nature of the complexes. The ligand and its metal complexes have shown antifungal activity with their LD50 values determined by probit analysis against two economically important fungal plant pathogens i.e. Macrophomina phaseolina and Fusarium solani.
authors.affiliation: Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi 110 002, India. Electronic address: mnk02tyg@yahoo.co.in.
authors.forename: Monika
authors.initials: M
authors.lastname: Tyagi
authors.forename: Sulekh
authors.initials: S
authors.lastname: Chandra
authors.forename: Jameel
authors.initials: J
authors.lastname: Akhtar
authors.forename: Dinesh
authors.initials: D
authors.lastname: Chand
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D010944:Plants / Q000382:microbiology; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel
keywords: Antifungal studies; LD(50); Macrocyclic ligand; Spectroscopic characterization; Transition metal complexes