title: Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice.
abstract: Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Sabelström
authors.forename: Moa
authors.initials: M
authors.lastname: Stenudd
authors.forename: Pedro
authors.initials: P
authors.lastname: Réu
authors.forename: David O
authors.initials: DO
authors.lastname: Dias
authors.forename: Marta
authors.initials: M
authors.lastname: Elfineh
authors.forename: Sofia
authors.initials: S
authors.lastname: Zdunek
authors.forename: Peter
authors.initials: P
authors.lastname: Damberg
authors.forename: Christian
authors.initials: C
authors.lastname: Göritz
authors.forename: Jonas
authors.initials: J
authors.lastname: Frisén
mesh_terms: D000818:Animals; D017209:Apoptosis; D001253:Astrocytes / Q000502:physiology; D001369:Axons / Q000502:physiology*; D002470:Cell Survival; D002921:Cicatrix / Q000473:pathology*; D051858:Forkhead Transcription Factors / Q000235:genetics; D011905:Genes, ras; D051379:Mice; D008817:Mice, Mutant Strains; D058953:Neural Stem Cells / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000473:pathology*
chemical_list: C481963:FOXJ1 protein, mouse; D051858:Forkhead Transcription Factors