title: Multiple verruciform xanthomas in the setting of congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome.
abstract: Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disease characterized by peculiar cutaneous presentations and skeletal abnormalities. Verruciform xanthoma (VX)-like histologic changes occasionally occur in CHILD syndrome, but typical VX-like lesions coexisting with CHILD syndrome are rare. In this study we report a rare case of multiple, coexisting VXs on the vulva and left lower limb of an 11-year-old Chinese girl who also exhibited the typical clinical presentations and limb defects of CHILD syndrome. Histologic and immunohistochemical analyses showed that the lesions were typical VXs.
authors.affiliation: Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China.
authors.forename: Xiu-Lian
authors.initials: XL
authors.lastname: Xu
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Sun
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D002648:Child; D015897:Comorbidity; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000473:pathology*; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000473:pathology*; D017880:Limb Deformities, Congenital / Q000473:pathology*; D014860:Warts / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*