title: Angiotensin-converting enzymes play a dominant role in fertility.
abstract: According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%-20% incidence worldwide. An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China. jinfan@zju.edu.cn.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Pan
authors.forename: Qi-Tao
authors.initials: QT
authors.lastname: Zhan
authors.forename: Fang
authors.initials: F
authors.lastname: Le
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Zheng
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
mesh_terms: D000818:Animals; D005298:Fertility / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism*
chemical_list: D007703:Peptidyl-Dipeptidase A