title: Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction.
abstract: OBJECTIVE
  Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI.
  
  
  METHODS
  58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated.
  
  
  RESULTS
  The MMP-8 levels were significantly higher in post-MI patients [median 3.88 ng/ml, interquartile range (1.88-6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002).
  
  
  CONCLUSIONS
  Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function.
authors.affiliation: Department of Cardiology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey. ayhanerkol@yahoo.com.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Erkol
authors.forename: Selçuk
authors.initials: S
authors.lastname: Pala
authors.forename: Vecih
authors.initials: V
authors.lastname: Oduncu
authors.forename: Alev
authors.initials: A
authors.lastname: Kılıcgedik
authors.forename: Filiz
authors.initials: F
authors.lastname: Kızılırmak
authors.forename: Can Yücel
authors.initials: CY
authors.lastname: Karabay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Güler
authors.forename: Cevat
authors.initials: C
authors.lastname: Kırma
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000503:physiopathology; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D020784:Matrix Metalloproteinase 8