title: Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease.
abstract: Studies indicate the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of Alzheimer's disease (AD). Decreased BDNF levels may constitute a lack of trophic support and contribute to cognitive impairment in AD. The benefits of acute and chronic physical exercise on BDNF levels are well-documented in humans, however, exercise effects on BDNF levels have not been analyzed in older adults with AD. The aim of this study was to investigate the effects of acute aerobic exercise on BDNF levels in older adults with AD and to verify associations among BDNF levels, aerobic fitness, and level of physical activity. Using a controlled design, twenty-one patients with AD (76.3 ± 6.2 years) and eighteen healthy older adults (74.6 ± 4.7 years) completed an acute aerobic exercise. The outcomes included measures of BDNF plasma levels, aerobic fitness (treadmill grade, time to exhaustion, VO2, and maximal lactate) and level of physical activity (Baecke Questionnaire Modified for the Elderly). The independent t-test shows differences between groups with respect to the BDNF plasma levels at baseline (p = 0.04; t = 4.53; df = 37). In two-way ANOVA, a significant effect of time was found (p = 0.001; F = 13.63; df = 37), the aerobic exercise significantly increased BDNF plasma levels in AD patients and healthy controls. A significant correlation (p = 0.04; r = 0.33) was found between BDNF levels and the level of physical activity. The results of our study suggest that aerobic exercise increases BDNF plasma levels in patients with AD and healthy controls. In addition to that, BDNF levels had association with level of physical activity.
authors.affiliation: Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil.
authors.forename: Flávia Gomes de Melo
authors.initials: FG
authors.lastname: Coelho
authors.affiliation: Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil.
authors.forename: Thays Martins
authors.initials: TM
authors.lastname: Vital
authors.affiliation: Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil.
authors.forename: Angelica Miki
authors.initials: AM
authors.lastname: Stein
authors.affiliation: Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil.
authors.forename: Franciel José
authors.initials: FJ
authors.lastname: Arantes
authors.affiliation: Institute of Biomedical Sciences, USP, University of São Paulo, Department of Pharmacology, Laboratory of Neurochemistry and Behavioral Pharmacology, São Paulo, SP, Brazil.
authors.forename: André Veloso
authors.initials: AV
authors.lastname: Rueda
authors.affiliation: Institute of Biomedical Sciences, USP, University of São Paulo, Department of Pharmacology, Laboratory of Neurochemistry and Behavioral Pharmacology, São Paulo, SP, Brazil.
authors.forename: Rosana
authors.initials: R
authors.lastname: Camarini
authors.affiliation: Center of Mathematics, Computing and Cognition, UFABC, University Federal of ABC, Santo André, SP, Brazil.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Teodorov
authors.affiliation: Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil Center of Mathematics, Computing and Cognition, UFABC, University Federal of ABC, Santo André, SP, Brazil.
authors.forename: Ruth Ferreira
authors.initials: RF
authors.lastname: Santos-Galduróz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D000704:Analysis of Variance; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D010809:Physical Fitness; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Aerobic exercise; Alzheimer's disease; brain-derived neurotrophic factor; neurotrophic factors; physical activity