title: Study of enantioselectivity on an immobilized amylose carbamate stationary phase under subcritical fluid chromatography.
abstract: In this paper, we describe the enantiomeric separation of a chiral alcohol under subcritical fluid chromatography conditions using a 3 μm particle size bonded amylose carbamate stationary phase. Linear and branched alcohols were used as polar modifiers in CO2. The studies with linear alcohols showed a decrease in selectivity factor as the number of carbons in the linear chain increased. For branched alcohols, as the bulk of substituents at the α carbon atom increases the separation factor decreases. Thermodynamic studies showed that in the presence of the alcohols studies, except methanol and ethanol, a positive ΔΔS was observed. Molecular mechanics simulation brought more insights into the mechanism of enantiomeric separation on this stationary phase under subcritical fluid chromatography.
authors.forename: Catharine
authors.initials: C
authors.lastname: Layton
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Ling
authors.initials: L
authors.lastname: Wu
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Keith
authors.initials: K
authors.lastname: Fandrick
authors.forename: Daniel
authors.initials: D
authors.lastname: Fandrick
authors.forename: Chris
authors.initials: C
authors.lastname: Senanyake
authors.forename: Nathan
authors.initials: N
authors.lastname: Yee
authors.forename: Nelu
authors.initials: N
authors.lastname: Grinberg
authors.forename: Jody
authors.initials: J
authors.lastname: Clark
mesh_terms: D000438:Alcohols / Q000302:isolation & purification; D000688:Amylose / Q000031:analogs & derivatives / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid; D010316:Particle Size; D013237:Stereoisomerism; D013499:Surface Properties
chemical_list: D000438:Alcohols; D002219:Carbamates; D000688:Amylose