title: Progressive multifocal leukoencephalopathy in an immunocompetent patient?
abstract: BACKGROUND
  Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease or immunosuppression-associated condition.
  
  
  METHODS
  We present a 72-year-old previously healthy woman who developed a progressive neurological condition affecting the entire nervous system which led to her death within 5 months. PML was diagnosed at autopsy.
  
  
  CONCLUSIONS
  PML should be considered in patients with progressive neurological disorders involving the white matter, even in the absence of previous immunomodulatory treatment or immunosuppression.
authors.affiliation: Department of Neurology, St Olavs University Hospital, Trondheim, Norway ; Department of Neuroscience, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Krisztina K
authors.initials: KK
authors.lastname: Johansen
authors.forename: Sverre H
authors.initials: SH
authors.lastname: Torp
authors.forename: Jana
authors.initials: J
authors.lastname: Rydland
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
keywords: Hypogammaglobulinemia; Idiopathic CD4+ T-lymphocytopenia; JC virus; Progressive multifocal leukoencephalopathy