title: Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon.
abstract: We report a multimodal optical approach using both Raman spectroscopy and optical coherence tomography (OCT) in tandem to discriminate between colonic adenocarcinoma and normal colon. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. We combine the chemical information derived from Raman spectroscopy with the texture parameters extracted from OCT images. The sensitivity obtained using Raman spectroscopy and OCT individually was 89% and 78% respectively and the specificity was 77% and 74% respectively. Combining the information derived using the two techniques increased both sensitivity and specificity to 94% demonstrating that combining complementary optical information enhances diagnostic accuracy. These data demonstrate that multimodal optical analysis has the potential to achieve accurate non-invasive cancer diagnosis.
authors.affiliation: SUPA, School of Physics & Astronomy, North Haugh, University of St Andrews, St Andrews, Fife, Scotland KY16 9SS UK.
authors.forename: Praveen C
authors.initials: PC
authors.lastname: Ashok
authors.forename: Bavishna B
authors.initials: BB
authors.lastname: Praveen
authors.forename: Nicola
authors.initials: N
authors.lastname: Bellini
authors.forename: Andrew
authors.initials: A
authors.lastname: Riches
authors.forename: Kishan
authors.initials: K
authors.lastname: Dholakia
authors.forename: C Simon
authors.initials: CS
authors.lastname: Herrington
keywords: (110.4500) Optical coherence tomography; (170.4580) Optical diagnostics for medicine; (170.4730) Optical pathology; (170.5660) Raman spectroscopy; (170.6510) Spectroscopy, tissue diagnostics; (180.5655) Raman microscopy