title: Creating diversity by site-selective peptide modification: a customizable unit affords amino acids with high optical purity.
abstract: The development of peptide libraries by site-selective modification of a few parent peptides would save valuable time and materials in discovery processes, but still is a difficult synthetic challenge. Herein natural hydroxyproline is introduced as a "convertible" unit for the production of a variety of optically pure amino acids, including expensive N-alkyl amino acids, and to achieve the mild, efficient, and site-selective modification of peptides.
authors.affiliation: Instituto de Productos Naturales y Agrobiología del CSIC , Avda. Astrofísico Fco. Sánchez, 3, 38206-La Laguna, Tenerife, Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Romero-Estudillo
authors.forename: Alicia
authors.initials: A
authors.lastname: Boto
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D006909:Hydroxyproline / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D010455:Peptides; D006909:Hydroxyproline