title: Clinical neurogenetics: recent advances in the genetics of epilepsy.
abstract: Epilepsy represents a diverse group of disorders with primary and secondary genetic etiologies, as well as non-genetic causes. As more causative genes are identified, genetic testing is becoming increasingly important in the evaluation and management of epilepsy. This article outlines the clinical approach to epilepsy patients, with emphasis on genetic testing. Specific targeted tests are available for numerous individual genetic causes of epilepsy. Broader screening tests, such as chromosome microarray analysis and whole exome sequencing, have also been developed. As a standardized protocol for genetic testing has not been established, individualized diagnostic approaches to epilepsy patients should be used.
authors.affiliation: Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: Rohini
authors.initials: R
authors.lastname: Coorg
authors.forename: Judith L Z
authors.initials: JL
authors.lastname: Weisenberg
authors.forename: Michael
authors.initials: M
authors.lastname: Wong
mesh_terms: D004827:Epilepsy / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans
keywords: Epilepsy; Genetics; Seizure