title: Four-component domino strategy for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines.
abstract: An efficient one-pot four-component domino protocol for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines has been achieved. This transformation presumably occurs via cyclization-Knoevenagel condensation-Michael addition-tautomerism-intramolecular O-cyclization-elimination sequence of reactions. The significant features of this reaction include expedient one-pot process, short reaction time, no column chromatographic purification, excellent yield, and readily available starting materials.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu, India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Kanchithalaivan
authors.forename: Sathiyamoorthi
authors.initials: S
authors.lastname: Sivakumar
authors.forename: Raju
authors.initials: R
authors.lastname: Ranjith Kumar
authors.forename: Palani
authors.initials: P
authors.lastname: Elumalai
authors.forename: Qazi Naveed
authors.initials: QN
authors.lastname: Ahmed
authors.forename: Anil K
authors.initials: AK
authors.lastname: Padala
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D011714:Pyrans; D011720:Pyrazoles