title: Respiratory induced dynamic variations of stroke volume and its surrogates as predictors of fluid responsiveness: applicability in the early stages of specific critical states.
abstract: Respiratory induced dynamic variations of stroke volume and its surrogates are very sensitive and specific predictors of fluid responsiveness, but their use as targets for volume management can be limited. In a recent study, limiting factors were present in 53 % of surgical patients with inserted arterial line. In the intensive care unit (ICU) population the frequency is presumably higher, but the real prevalence is unknown. Our goal was to study the feasibility of dynamic variations guided initial volume resuscitation in specific critical states. We have performed a 5 year retrospective evaluation of patients admitted with diagnosis sepsis, polytrauma, after high risk surgery or cardiac arrest. Occurrence of major (sedation, mandatory ventilation and tidal volume, open chest and arrhythmias) and minor limiting factors (PEEP level, use of vasopressors and presence of arterial catheter) was screened within the first 24 h after admission. In the study period 1296 patients were hospitalized in our ICU with severe sepsis (n = 242), polytrauma (n = 561), after high risk surgery (n = 351) or cardiac arrest (n = 141). From these patients 549 (42.4 %) fulfilled all major criteria for applicability of dynamic variations. In our evaluation only limited number of patients admitted for polytrauma (51 %), sepsis (37 %), after cardiac arrest (39 %) or surgical procedure (33 %) fulfil all the major criteria for use of dynamic variations at the ICU admission. The prevalence was similar in patients with shock. Occurrence of minor factors can pose further bias in evaluation of these patients. General use of dynamic variations guided protocols for initial resuscitations seems not universally applicable.
authors.affiliation: Department of Anesthesiology and Intensive Care, The University Hospital and The Faculty of Medicine in Plzen, Charles University Prague, Alej Svobody 80, 304 60, Plzeň, Czech Republic, benesj@fnplzen.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Benes
authors.forename: Jan
authors.initials: J
authors.lastname: Zatloukal
authors.forename: Jakub
authors.initials: J
authors.lastname: Kletecka
authors.forename: Alena
authors.initials: A
authors.lastname: Simanova
authors.forename: Lenka
authors.initials: L
authors.lastname: Haidingerova
authors.forename: Richard
authors.initials: R
authors.lastname: Pradl
mesh_terms: D003131:Combined Modality Therapy; D016638:Critical Illness / Q000628:therapy*; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods*; D015203:Reproducibility of Results; D012121:Respiration, Artificial / Q000379:methods*; D012151:Resuscitation / Q000379:methods*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome