title: Is ABCC6 a genuine mitochondrial protein?
abstract: BACKGROUND
  A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with dysfunction in mitochondria--Martin et al.: ABCC6 Localizes to the Mitochondria-Associated Membrane.Circ Res 2012, 111:516-520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria.
  
  
  RESULTS
  All the computational strategies and integrative approaches that constitute references in the field indicate that ABCC6 is localized outside of mitochondria.
  
  
  CONCLUSIONS
  Our computational and integrative results, including both experimental and predictive data, show that there is no support in favor of the localization of ABCC6 in mitochondria.
authors.affiliation: CNRS 6214/INSERM 1083, Angers University, Angers, France. MaFerre@chu-angers.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Ferré
authors.forename: Pascal
authors.initials: P
authors.lastname: Reynier
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chevrollier
authors.forename: Delphine
authors.initials: D
authors.lastname: Prunier-Mirebeau
authors.forename: Georges
authors.initials: G
authors.lastname: Lefthériotis
authors.forename: Daniel
authors.initials: D
authors.lastname: Henrion
authors.forename: Dominique
authors.initials: D
authors.lastname: Bonneau
authors.forename: Vincent
authors.initials: V
authors.lastname: Procaccio
authors.forename: Ludovic
authors.initials: L
authors.lastname: Martin
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D002114:Calcinosis / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D011561:Pseudoxanthoma Elasticum / Q000378:metabolism*
chemical_list: D018528:ATP-Binding Cassette Transporters