title: Clinical characteristics and HPV type in recurrent respiratory papillomatosis in Colombia.
abstract: OBJECTIVE
  Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP).
  
  
  METHODS
  One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1).
  
  
  RESULTS
  113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness.
  
  
  CONCLUSIONS
  The age at diagnosis was the main determinant of RRP aggressiveness.
authors.affiliation: Centro Médico Imbanaco, Cali, Colombia.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Cuello
authors.forename: Gloria I
authors.initials: GI
authors.lastname: Sánchez
authors.forename: Roberto
authors.initials: R
authors.lastname: Jaramillo
authors.forename: Katherine
authors.initials: K
authors.lastname: Quintero
authors.forename: Armando
authors.initials: A
authors.lastname: Baena
authors.forename: Adriana
authors.initials: A
authors.lastname: O'Byrne
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Reyes
authors.forename: Consuelo
authors.initials: C
authors.lastname: Santamaría
authors.forename: Julio C
authors.initials: JC
authors.lastname: Reina
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000821:virology*; D012141:Respiratory Tract Infections / Q000821:virology*; D012189:Retrospective Studies; D055815:Young Adult