title: No pain, more gain.
abstract: A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.
authors.affiliation: Molecular Nociception Group at the Wolfson Institute for Biomedical Research, University College London, London, UK.
authors.forename: James J
authors.initials: JJ
authors.lastname: Cox
authors.forename: John N
authors.initials: JN
authors.lastname: Wood
mesh_terms: D000818:Animals; D006801:Humans; D062558:NAV1.9 Voltage-Gated Sodium Channel / Q000235:genetics; D010146:Pain / Q000235:genetics*; D058748:Pain Perception / Q000502:physiology*
chemical_list: D062558:NAV1.9 Voltage-Gated Sodium Channel; C491886:SCN11A protein, human