title: Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review.
abstract: We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dose chemotherapy with blood stem cell rescue with no evidence of disease.The role of high dose chemotherapy with blood stem cell rescue to consolidate the complete clearing of lung disease in metastatic hepatoblastoma remains controversial; the data available in the literature and our experience seems to suggest to keep this treatment option open to further consideration in the clinical setting of high-risk patients.
authors.forename: Massimo
authors.initials: M
authors.lastname: Provenzi
authors.affiliation: Department of Pediatrics, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, Monza, 20900, Italy. francescosaettini@yahoo.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Saettini
authors.forename: Valentino
authors.initials: V
authors.lastname: Conter
authors.forename: Eugenia
authors.initials: E
authors.lastname: Giraldi
authors.forename: Carlo
authors.initials: C
authors.lastname: Foglia
authors.forename: Laura
authors.initials: L
authors.lastname: Cavalleri
authors.forename: Michele
authors.initials: M
authors.lastname: Colledan
authors.forename: Lorenzo
authors.initials: L
authors.lastname: D'Antiga
authors.forename: Giorgio
authors.initials: G
authors.lastname: Perilongo
authors.forename: Liviana
authors.initials: L
authors.lastname: Da Dalt
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001707:Biopsy, Needle; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D018197:Hepatoblastoma / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D018570:Risk Assessment; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome