title: Rationale, design, and baseline characteristics of a community-based comparative effectiveness trial to prevent type 2 diabetes in economically disadvantaged adults: the RAPID Study.
abstract: Reaching Out and Preventing Increases in Diabetes (RAPID) is a community-based randomized trial evaluating the comparative costs and effectiveness of a group-based adaption of the DPP lifestyle intervention developed and implemented in partnership with the YMCA. RAPID enrolled adult primary care patients, with BMI 24 kg/m(2) or higher and abnormal glucose metabolism (HbA1c 5.7-6.9% or fasting plasma glucose 100-125 mg/dL). 509 participants were enrolled and randomized to one of two groups: standard clinical advice plus free-of-charge access to a group-based adaption of the DPP offered by the Y, versus standard clinical advice alone. Key outcomes for future analysis will include differences in body weight and other cardiovascular risk factors over a 24-month intervention period. At baseline, RAPID participants had a mean (SD) age of 51 ± 12.1 years, weight of 225.1 ± 56.2 lbs, and BMI of 36.9 ± 8.6 kg/m(2). 70.7% were women, 57.2% were African American, 35.4% were non-Hispanic White, and 3.2% were Hispanic. Mean HbA1c was 6.05 ± 0.34%. Additionally, 55.4% of participants had a baseline systolic blood pressure of ≥130 mmHg, 33.1% had a total blood cholesterol exceeding 200mg/dL, and 74% reported a household income of <$25,000. The RAPID Study successfully randomized a large cohort of participants with a wide distribution of age, body weight, and race who are at high risk for developing type 2 diabetes.
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N. Lake Shore Dr., 10th Floor, Chicago, IL 60611, United States. Electronic address: r.ackermann@northwestern.edu.
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Ackermann
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N. Lake Shore Dr., 10th Floor, Chicago, IL 60611, United States.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Finch
authors.affiliation: Department of Medicine, Indiana University School of Medicine, 410 W 10th St, Suite 3000, Indianapolis, IN 46202, United States.
authors.forename: Karen K
authors.initials: KK
authors.lastname: Schmidt
authors.affiliation: Department of Biostatistics, Indiana University School of Medicine, 410 W 10th St, Suite 3000, Indianapolis, IN 46202, United States.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Hoen
authors.affiliation: Indiana University School of Nursing, Indianapolis, 1111 Middle Dr., Indianapolis, IN 46202, United States.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Hays
authors.affiliation: Department of Medicine, Indiana University School of Medicine, 410 W 10th St, Suite 3000, Indianapolis, IN 46202, United States.
authors.forename: David G
authors.initials: DG
authors.lastname: Marrero
authors.affiliation: Department of Biostatistics, Indiana University School of Medicine, 410 W 10th St, Suite 3000, Indianapolis, IN 46202, United States.
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
mesh_terms: D000328:Adult; D057186:Comparative Effectiveness Research; D003376:Counseling; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005081:Exercise Therapy; D005260:Female; D006297:Health Services Accessibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D050177:Overweight / Q000628:therapy; D011203:Poverty; D040242:Risk Reduction Behavior; D061217:Weight Reduction Programs
keywords: Community research; Lifestyle intervention; Overweight/obesity; Pre-diabetes; Primary prevention; Type 2 diabetes mellitus