title: Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients.
abstract: BACKGROUND
  The relationship of platelet volume indices including mean platelet volume (MPV) and platelet distribution width (PDW) with carotid intima-media thickness (IMT) as well as vibration perception threshold (VPT) was investigated in type 2 diabetic patients.
  
  
  METHODS
  A total of 500 type 2 diabetic patients (298 male, 202 female) were enrolled. Clinical and laboratory data were collected from hospital records.
  
  
  RESULTS
  Both MPV and PDW were significantly associated with carotid IMT, after adjustment for confounding factors including age, systolic blood pressure, total cholesterol and creatinine (0.833 ± 0.029 mm vs. 0.955 ± 0.030 mm; 0.839 ± 0.029 mm vs. 0.955 ± 0.030 mm; P = 0.0015 and P = 0.022, respectively). Agreed with carotid IMT analysis results, significant association was found between PDW and VPT as tertiles (15.760 ± 1.091V vs 20.187 ± 1.094V, P = 0.016). In multivariable analysis, both MPV and PDW were significantly associated with VPT (P = 0.021 and P = 0.007, respectively). However, only PDW, but not MPV, was significantly associated with carotid IMT (P = 0.002).
  
  
  CONCLUSIONS
  These findings implied the predictive value of platelets volume indices in vascular and peripheral neuropathy complications in type 2 diabetes.
authors.affiliation: Department of Endocrinology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Xiao
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Jixiang
authors.initials: J
authors.lastname: Dong
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D048909:Diabetes Complications / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis
chemical_list: D001786:Blood Glucose
keywords: intima-media thickness; mean platelet volume; platelet distribution width; type 2 diabetes; vibration perception threshold; 颈动脉内中膜增厚，平均血小板体积，血小板分布宽度，2型糖尿病，震动感觉阈值