title: Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy.
abstract: With limited clinical trials on stem cell therapy for adult stroke underway, the assessment of efficacy also needs to be considered for neonatal hypoxic-ischemic brain injury, considering its distinct symptoms. The critical nature of this condition leads to establishment of deficits that last a lifetime. Here, we will highlight the progress of current translational research, commenting on the critical nature of the disease, stem cell sources, the use of hypothermia, safety and efficacy of each treatment, modes of action, and the possibility of combination therapy. With this in mind, we reference translational guidelines established by a consortium of research partners called Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS). The guidelines of STEPS are directed toward evaluating outcomes of cell therapy in adult stroke; however, we identify the overlapping pathology, as we believe that these guidelines will serve well in the investigation of neonatal hypoxic-ischemic therapy. Finally, we discuss emerging treatments and a case report, altogether suggesting that the potential for these treatments to be used in synergy has arrived and the time for advancing stem cell use in combination with hypothermia for cerebral palsy is now.
authors.affiliation: Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Dailey
authors.forename: Yusef
authors.initials: Y
authors.lastname: Mosley
authors.forename: Mibel
authors.initials: M
authors.lastname: Pabon
authors.forename: Sandra
authors.initials: S
authors.lastname: Acosta
authors.forename: Naoki
authors.initials: N
authors.lastname: Tajiri
authors.forename: Harry
authors.initials: H
authors.lastname: van Loveren
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
mesh_terms: D002547:Cerebral Palsy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003422:Critical Care; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000601:surgery / Q000628:therapy*; D007231:Infant, Newborn; D033581:Stem Cell Transplantation; D057170:Translational Research, Biomedical