title: Clinical profile of hospitalized HIV-infected children in Bangladesh, a low-HIV-prevalence country.
abstract: BACKGROUND
  Bangladesh has a low HIV prevalence and data on the risk factors and clinical presentation of HIV-infected children are lacking.
  
  
  OBJECTIVE
  To describe the clinical characteristics of hospitalized HIV-infected children in Bangladesh and determine the factors associated with a low CD4 count.
  
  
  METHODS
  An anonymous, retrospective review was undertaken of the medical records of all patients admitted to the HIV unit of the iccdr,b Dhaka Hospital between February 2009 and July 2012. Demographic, clinical and laboratory data were extracted from the electronic medical record system. HIV-infected children with a low absolute CD4 count (<200 cells/μl) were compared with HIV-infected children with a CD4 count ≧200 cells/μl.
  
  
  RESULTS
  Of 266 HIV-infected patients, 24 were children (9%), 13 (54%) of whom were male. Ages ranged from 2 to 17 years (median 7). Of the 21 (88%) children who acquired the infection by vertical transmission, median age at diagnosis was 5·2 years, and the parents of 19 (79%) reported a history of external migration. Children commonly presented with prolonged fever (n = 14, 58%), recurrent cough (n = 14, 58%), failure to thrive (n = 11, 46%) and recurrent diarrhoea (n = 4, 17%). Six (25%) patients had tuberculosis, four (16·7%) had herpes zoster and four (16·7%) were diagnosed with Pneumocystis jirovecii pneumonia. One child died during hospitalization. Children with a low CD4 count (<200 cells/μl) more often had severe wasting (95% CI 1·2-453·97) and severe under-nutrition (95% CI 1·39-196·25) than those with a higher CD4 count*.
  
  
  CONCLUSIONS
  The majority of HIV-infected children presenting to an inpatient speciality ward in Dhaka acquired HIV through vertical transmission, and most of the parents had a history of external migration. Further studies are needed to determine the optimal strategy for preventing mother-to-child transmission and for early identification and treatment of HIV-infected children in this low-prevalence country.
authors.forename: Lubaba
authors.initials: L
authors.lastname: Shahrin
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Leung
authors.forename: Nashaba
authors.initials: N
authors.lastname: Matin
authors.forename: Chowdhury Ali
authors.initials: CA
authors.lastname: Kawser
authors.forename: Mohammed Moshtaq
authors.initials: MM
authors.lastname: Pervez
authors.forename: Mohammod Jobayer
authors.initials: MJ
authors.lastname: Chisti
mesh_terms: D000293:Adolescent; D001459:Bangladesh / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000473:pathology* / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Bangladesh,; CD4 count; Children,; HIV infection,; Low-HIV-prevalence country,