title: Estimation of unbiased recombination values in the presence of misclassification of a trait using RFLP maps.
abstract: The effect of misclassification of phenotypes of a trait on the estimation of recombination value was investigated. The effect was larger for closer linkage. If a locus is dominant and linked with the misclassfied trait locus in the repulsion phase, then the effect on the recombination value between the two loci is largest. A method for estimating the unbiased recombination value and the misclassification rate using maximum likelihood associated with an EM algorithm is also presented. This method was applied to a numerical example from rice genome data. It was concluded that the present method combined with the metric multi-dimensional scaling method is useful for the detection of misclassified markers and for the estimation of unbiased recombination values.
authors.affiliation: Laboratory of Biometrics, Division of Agriculture and Agricultural Life Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo, 113, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Cheng
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Ukai