title: New sesquiterpenoid derivatives from Solanum lyratum and their cytotoxicities.
abstract: Three new sesquiterpenoid isopropylidene derivatives, named solajiangxins H and I (1 and 2) and 7-hydroxylsolajiangxin I (3), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D NMR, and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY). In vitro, compounds 1-3 were found to show significant cytotoxicity against three cancer cells (P-388, HONE-1, and HT-29), and gave IC50 values in the range of 3.2-7.7 μM.
authors.affiliation: a School of Pharmaceutical Science, Yantai University , Yantai , 264005 , China.
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Yao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Xi-Dian
authors.initials: XD
authors.lastname: Yue
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*
chemical_list: C587082:7-hydroxylsolajiangxin I; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012717:Sesquiterpenes; C587081:solajiangxin H