title: Antileishmanial activity of some plants growing in Algeria: Juglans regia, Lawsonia inermis and Salvia officinalis.
abstract: The current study was undertaken to evaluate in vitro the antileishmanial activity of three plants growing wild in Algeria : Juglans regia, Lawsonia inermis and Salvia officinalis. The hydroalcoholic extracts of these plants were tested on the growth of the promastigotes of Leishmania major. The plant extract effects were compared with three controls : CRL1 composed of 1 ml RPMI inoculated with 10(6) of promastigotes, CRL2 composed of 1 ml RPMI inoculated with 10(6) of promastigotes and 100 µl of hydroalcoholic solvent, CRL3 composed of 1 ml RPMI inoculated with 10(6) of promastigotes and 100 µl of Glucantim as a reference drug in the management of leishmaniasis. The results showed that both J. regia and L. inermis extracts reduced the promastigotes number significantly (P<0.01). however, S. officinalis showed a total inhibition of the Leishmania major growth.
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Département des Sciences Vétérinaires, Université Mentouri de Constantine, Algérie.
authors.forename: M
authors.initials: M
authors.lastname: Serakta
authors.forename: Z
authors.initials: Z
authors.lastname: Djerrou
authors.forename: H
authors.initials: H
authors.lastname: Mansour-Djaalab
authors.forename: F
authors.initials: F
authors.lastname: Kahlouche-Riachi
authors.forename: S
authors.initials: S
authors.lastname: Hamimed
authors.forename: W
authors.initials: W
authors.lastname: Trifa
authors.forename: A
authors.initials: A
authors.lastname: Belkhiri
authors.forename: N
authors.initials: N
authors.lastname: Edikra
authors.forename: Y
authors.initials: Y
authors.lastname: Hamdi Pacha
mesh_terms: D000462:Algeria; D031324:Juglans; D031564:Lawsonia Plant; D018320:Leishmania major / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D027543:Salvia officinalis; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents
keywords: Juglans regia; Lawsonia inermis; Leishmania major; Salvia officinalis; anti-leishmanial activity