title: Predictive ability of the anthropometric and body composition indicators for detecting changes in inflammatory biomarkers.
abstract: BACKGROUND
  Obesity has been considered a chronic subclinical inflammation. High sensitivity C-reactive protein (hs-CRP) and fibrinogen are increasingly associated with cardiovascular risk.
  
  
  OBJECTIVE
  To evaluate the ability of anthropometric and body composition indicators in discriminating higher levels of hs-CRP and fibrinogen.
  
  
  METHODS
  130 men (20-59 years) were assessed, having measurement of weight, height, waist circumference (WC), hip and thigh circumferences, sagittal abdominal diameter (SAD), coronal diameter (CD) and body composition. Conicity index, waist/height ratio, body mass index, waist/hip ratio, waist/thigh ratio and sagittal index were calculated. It was considered as the cutoff point for hs-CRP values ≥ 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample.
  
  
  RESULTS
  Sagittal index (r = 0.280), waist/thigh ratio (r = 0.233) and waist/height ratio (r = 0.233) showed the best correlation with hs-CRP (p < 0.01). Conicity index (r = 0.305) and waist/height ratio (r = 0.279) showed the best correlation with fibrinogen (p < 0.01). In ROC analysis, the SAD (0.698 ± 0.049) and the conicity index (0.658 ± 0.048) had greater ability to discriminate cardiovascular risk through higher levels of hs-CRP and fibrinogen, respectively (p < 0.01). The cutoff points of 30 cm, 89.9 cm and 20.5 cm were the ones that reached largest sum between sensitivity and specificity values for the CD, WC and SAD, respectively.
  
  
  CONCLUSIONS
  The SAD and the conicity index demonstrated a greater ability to detect higher levels of hs-CRP and fibrinogen, respectively, in apparently healthy adult men.
authors.affiliation: Department of Nutrition and Health. Federal University of Viçosa. Minas Gerais. Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Carvalho Vidigal
authors.forename: Lina Enriqueta Frandsen
authors.initials: LE
authors.lastname: Paez de Lima Rosado
authors.forename: Gilberto
authors.initials: G
authors.lastname: Paixão Rosado
authors.forename: Rita
authors.initials: R
authors.lastname: de Cassia Lanes Ribeiro
authors.forename: Sylvia
authors.initials: S
authors.lastname: do Carmo Castro Franceschini
authors.forename: Silvia Eloiza
authors.initials: SE
authors.lastname: Priore
authors.forename: Eliana Carla
authors.initials: EC
authors.lastname: Gomes de Souza
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D001837:Body Weights and Measures; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein