title: Multiphasic and multifocal cryptococcal immune reconstitution inflammatory syndrome in an HIV-infected patient: interplay of infection and immunity.
abstract: We report a case of cryptococcal immune reconstitution inflammatory syndrome affecting the lungs, and 10 months later the cervical lymph nodes, in the absence of cryptococcal meningitis, in advanced HIV infection. Our report demonstrates the organ-specificity of the timing of the inflammatory response and illustrates the organ-specific interplay of immunity and infection in cryptococcal disease.
authors.affiliation: Department of Infectious Diseases and Gastroenterology, Auguste-Viktoria-Klinikum, Rubensstraße 125, 12157 Berlin, Germany. Electronic address: juri.katchanov@charite.de.
authors.forename: Juri
authors.initials: J
authors.lastname: Katchanov
authors.affiliation: Department of Pathology, Klinikum Neukölln, Berlin, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Zimmermann
authors.affiliation: Department of Radiology, Auguste-Viktoria-Klinikum, Berlin, Germany.
authors.forename: Gordian
authors.initials: G
authors.lastname: Branding
authors.affiliation: Reference Laboratory for Cryptococcus neoformans, Robert Koch Institute, Berlin, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Tintelnot
authors.affiliation: Department of Infectious Diseases and Gastroenterology, Auguste-Viktoria-Klinikum, Rubensstraße 125, 12157 Berlin, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.affiliation: Department of Infectious Diseases and Gastroenterology, Auguste-Viktoria-Klinikum, Rubensstraße 125, 12157 Berlin, Germany.
authors.forename: Keikawus
authors.initials: K
authors.lastname: Arastéh
authors.affiliation: Department of Infectious Diseases and Gastroenterology, Auguste-Viktoria-Klinikum, Rubensstraße 125, 12157 Berlin, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Stocker
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D003454:Cryptococcus / Q000187:drug effects; D004271:DNA, Fungal / Q000302:isolation & purification; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000188:drug therapy*; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy*; D019562:Viral Load
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal
keywords: Cryptococcus; HIV; IRIS; Lymphadenitis; Pulmonary cryptococcoma