title: Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein.
abstract: BACKGROUND
  Cardioprotective effect of high density lipoprotein (HDL) is, in part, dependent on its related enzyme, paraoxonase 1 (PON1). Fatty acid composition of HDL could affect its size and structure. On the other hand, PON1 activity is directly related to the structure of HDL. This study was designed to investigate the association between serum PON1 activity and fatty acid composition of HDL in healthy men.
  
  
  METHODS
  One hundred and forty healthy men participated in this research. HDL was separated by sequential ultracentrifugation, and its fatty acid composition was analyzed by gas chromatography. PON1 activity was measured spectrophotometrically using paraxon as substrate.
  
  
  RESULTS
  Serum PON1 activity was directly correlated with the amount of stearic acid and dihomo-gamma-linolenic acid (DGLA). PON1/HDL-C was directly correlated with the amount of miristic acid, stearic acid, and DGLA and was inversely correlated with total amount of ω 6 fatty acids of HDL.
  
  
  CONCLUSIONS
  The fatty acid composition of HDL could affect the activity of its associated enzyme, PON1. As dietary fats are the major determinants of serum lipids and lipoprotein composition, consuming some special dietary fatty acids may improve the activity of PON1 and thereby have beneficial effects on health.
authors.affiliation: Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Boshtam
authors.forename: Amirnader Emami
authors.initials: AE
authors.lastname: Razavi
authors.forename: Morteza
authors.initials: M
authors.lastname: Pourfarzam
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ani
authors.forename: Gholam Ali
authors.initials: GA
authors.lastname: Naderi
authors.forename: Gholam
authors.initials: G
authors.lastname: Basati
authors.forename: Marjan
authors.initials: M
authors.lastname: Mansourian
authors.forename: Narges Jafari
authors.initials: NJ
authors.lastname: Dinani
authors.forename: Seddigheh
authors.initials: S
authors.lastname: Asgary
authors.forename: Soheila
authors.initials: S
authors.lastname: Abdi
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000032:analysis; D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D013229:Stearic Acids / Q000032:analysis
chemical_list: D008075:Lipoproteins, HDL; D013229:Stearic Acids; C031183:stearic acid; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D015126:8,11,14-Eicosatrienoic Acid