title: Determination of trace level cadmium in SRM 3280 Multivitamin/Multielement Tablets via isotope dilution inductively coupled plasma mass spectrometry.
abstract: Cadmium was quantified at 80.15±0.86 ng/g (mean±95% expanded uncertainty) in NIST SRM 3280 Multivitamin/Multielement Tablets, using isotope dilution mass spectrometry. The method described utilized various precipitation and solid-phase extraction separation methodologies to isolate Cd from Sn and Mo, present respectively, at 11.1±0.9 mg/kg and 70.7±4.5 mg/kg in the tablet matrix. This allowed for measurement of (111)Cd/(113)Cd and (111)Cd/(114)Cd isotope ratios using both quadrupole collision cell technology inductively coupled plasma mass spectrometry (Q-CCT-ICP-MS) and sector field (SF)-ICP-MS equipped with a desolvating nebulizer system to mitigate the MoO(+) and MoOH(+) molecular ion interferences that typically affect the envelope of Cd isotopes.
authors.affiliation: National Institute of Standards and Technology, Material Measurement Laboratory, Chemical Sciences Division, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, USA. Electronic address: steven.christopher@nist.gov.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Christopher
authors.forename: Robert Q
authors.initials: RQ
authors.lastname: Thompson
mesh_terms: D002104:Cadmium / Q000302:isolation & purification*; D007201:Indicator Dilution Techniques; D007554:Isotopes; D052616:Solid Phase Extraction; D013054:Spectrophotometry, Atomic / Q000379:methods*; D013607:Tablets; D013890:Thiourea / Q000737:chemistry; D014815:Vitamins / Q000032:analysis*
chemical_list: D007554:Isotopes; D013607:Tablets; D014815:Vitamins; D002104:Cadmium; D013890:Thiourea