title: Serum bilirubin level and aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease.
abstract: We investigated the association between serum bilirubin level and thoracic aortic intima-media thickness (IMT). The study population consisted of 417 patients without coronary artery disease, who underwent transesophageal echocardiography examination for various indications. The highest aortic IMT values were observed in the bilirubinlow group compared with the bilirubinhigh group (P < .001). Serum bilirubin level was associated with high-density lipoprotein cholesterol level (r = .162, P = .001), high-sensitivity C-reactive protein (hsCRP; r = -.265, P < .001), and aortic IMT (r = -.551, P < .001) in bivariate analysis. Multivariate linear regression analysis showed that serum bilirubin level was independently and negatively associated with hsCRP (β = -.095, P = .028) and aortic IMT (β = -.513, P < .001). Serum bilirubin level may be an independent predictor of the extent of subclinical aortic atherosclerosis assessed by thoracic aortic IMT.
authors.affiliation: 1Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Ahmet Oytun
authors.initials: AO
authors.lastname: Baykan
authors.forename: Nermin Yildiz
authors.initials: NY
authors.lastname: Koyunsever
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypakli
authors.forename: Omer
authors.initials: O
authors.lastname: Sen
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloglu
authors.forename: Taner
authors.initials: T
authors.lastname: Seker
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.forename: Selehattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Durmus Yildiray
authors.initials: DY
authors.lastname: Sahin
authors.forename: Murat
authors.initials: M
authors.lastname: Çayli
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D001018:Aortic Diseases / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D002097:C-Reactive Protein; D001663:Bilirubin
keywords: aorta; atherosclerosis; bilirubin; intima–media thickness