title: Neuronal differences between chronic low back pain and depression regarding long-term habituation to pain.
abstract: BACKGROUND
  Longitudinal studies of experimental pain are rare and little is known about the differences regarding sensitization and habituation over longer periods in patients with chronic pain or depression compared with controls.
  
  
  METHODS
  We used a standardized longitudinal painful heat paradigm that was designed to induce long-term habituation in 19 patients with chronic low back pain (CLBP), 21 patients with depression (DEP) and 21 healthy participants (controls) over a time course of eight consecutive days. We applied functional magnetic resonance imaging on the first and last day of this period and after 3 months.
  
  
  RESULTS
  Although the pain paradigm was standardized, patients with DEP exhibited significantly higher pain thresholds and a trend to higher pain ratings and, in functional imaging, showed less activation of the operculum and the secondary somatosensory cortex (S2) as compared to patients with CLBP and controls. Conversely, patients with CLBP showed increased activation in the anterior insula and parietal operculum as compared to patients with DEP and controls. Within session, all participants sensitized to pain, which was associated with higher activation levels in the thalamus, amygdala, midcingulate cortex, and sensory and motor areas. However, patients with depression showed significantly less activation in midbrain and brainstem areas.
  
  
  CONCLUSIONS
  Given that pain and depression potentiate each other clinically, our data suggest that this may involve different cortical pain areas.
authors.affiliation: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez-Raecke
authors.forename: K
authors.initials: K
authors.lastname: Ihle
authors.forename: C
authors.initials: C
authors.lastname: Ritter
authors.forename: C
authors.initials: C
authors.lastname: Muhtz
authors.forename: C
authors.initials: C
authors.lastname: Otte
authors.forename: A
authors.initials: A
authors.lastname: May
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003863:Depression / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D017116:Low Back Pain / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D010146:Pain / Q000503:physiopathology / Q000523:psychology*; D010147:Pain Measurement; D058748:Pain Perception; D017288:Pain Threshold; D013997:Time Factors