title: Diastereoselective synthesis of the C14–C29 fragment of amphidinol.
abstract: An efficient stereoselective synthesis of the C14–C29 fragment highlighting a coupling reaction between a 1,3-dithiane derivative and an α-branched aldehyde was realized. This highly convergent synthesis involved two chiral pools, L-malic acid and (+)-camphorsulfonic acid, which are the starting compounds to control the six stereogenic centers present in the C14–C29 fragment of amphidinol 3.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rival
authors.forename: Gilles
authors.initials: G
authors.lastname: Hanquet
authors.forename: Charlelie
authors.initials: C
authors.lastname: Bensoussan
authors.forename: Sébastien
authors.initials: S
authors.lastname: Reymond
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
authors.forename: Françoise
authors.initials: F
authors.lastname: Colobert
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000095722:Amphidinols
chemical_list: D000475:Alkenes; D011714:Pyrans; C438973:amphidinol 3; D000095722:Amphidinols