title: Biomarkers in schizophrenia: a brief conceptual consideration.
abstract: Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia.
authors.affiliation: School of Psychiatry, University of New South Wales, Randwick, NSW 2031, Australia ; Neuroscience Research Australia, Hospital Road, Randwick, NSW 2031, Australia ; Schizophrenia Research Institute, Darlinghurst, NSW 2010, Australia.
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Weickert
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Weickert
authors.forename: Anil
authors.initials: A
authors.lastname: Pillai
authors.forename: Peter F
authors.initials: PF
authors.lastname: Buckley
mesh_terms: D015415:Biomarkers / Q000097:blood; D006801:Humans; D011379:Prognosis; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000628:therapy
chemical_list: D015415:Biomarkers