title: Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery.
abstract: A key challenge in the production of multicomponent nanoparticles for healthcare applications is obtaining reproducible monodisperse nanoparticles with the minimum number of preparation steps. This paper focus on the use of electrohydrodynamic (EHD) techniques to produce core-shell polymer-lipid structures with a narrow size distribution in a single step process. These nanoparticles are composed of a hydrophilic core for active component encapsulation and a lipid shell. It was found that core-shell nanoparticles with a tunable size range between 30 and 90 nm and a narrow size distribution could be reproducibly manufactured. The results indicate that the lipid component (stearic acid) stabilizes the nanoparticles against collapse and aggregation and improves entrapment of active components, in this case vanillin, ethylmaltol and maltol. The overall structure of the nanoparticles produced was examined by multiple methods, including transmission electron microscopy and differential scanning calorimetry, to confirm that they were of core-shell form.
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
authors.forename: Megdi
authors.initials: M
authors.lastname: Eltayeb
authors.forename: Eleanor
authors.initials: E
authors.lastname: Stride
authors.forename: Mohan
authors.initials: M
authors.lastname: Edirisinghe
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D011753:Pyrones / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013229:Stearic Acids / Q000737:chemistry*
chemical_list: D001547:Benzaldehydes; D011753:Pyrones; D013229:Stearic Acids; C008316:maltol; C031183:stearic acid; C100058:vanillin; C052408:ethyl maltol