title: Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities.
abstract: A simple, efficient, and environment friendly protocol for the synthesis of 1,3,5-triarylpyrazole and 1,3,5-triarylpyrazolines in [bimm][PF6] ionic liquid mediated by Cu(OTf)2is described. The reaction protocol gave 1,3,5-triarylpyrazoles in good to high yields (71-84%)viaa one-pot addition-cyclocondensation between chalcones and arylhydrazines, and oxidative aromatization without requirement for an additional oxidizing reagent. The catalyst can be reused up to four cycles without much loss in the catalytic activity. The pyrazoles (4a-o) and pyrazolines (3a-n) were evaluated for antiproliferative activity in SK-OV-3, HT-29, and HeLa human cancer cells lines. Among all compounds,3binhibited cell proliferation of HeLa cells by 80% at a concentration of 50 μM.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
authors.forename: V Kameshwara
authors.initials: VK
authors.lastname: Rao
authors.forename: Rakesh
authors.initials: R
authors.lastname: Tiwari
authors.forename: Bhupender S
authors.initials: BS
authors.lastname: Chhikara
authors.forename: Amir Nasrolahi
authors.initials: AN
authors.lastname: Shirazi
authors.forename: Keykavous
authors.initials: K
authors.lastname: Parang
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar