title: ALG/alg: a single gene controlling the utilization of lactate in the presence of antimycin in the yeast Saccharomyces cerevisiae.
abstract: A strain dependent growth on lactate in the presence of antimycin A (AA) has been observed - the strain D261 can grow on lactate and AA, whereas in the strain K8/6C antimycin A prevents the utilization of lactate and the induction of LDH.Genetic analysis demonstrates that growth on lactate in the presence of AA segregates from D261 as a single nuclear factor which we indicate by ALG1 and alg1 in its dominant and recessive states. alg1 complements the gene(s) which give(s) rise to the same phenotype in K8/6C.The analysis of the regulation by lactate of LDH in the absence and presence of AA and in rho (-) cells shows that growth on lactate and antimycin A is not corretated with the induction by lactate of LDH.
authors.affiliation: Institute of Genetics, University of Parma, borgo Carissimi 10, I-43100, Parma, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Ferrero
authors.forename: R
authors.initials: R
authors.lastname: Rambaldelli
authors.forename: A M
authors.initials: AM
authors.lastname: Genga
authors.forename: C
authors.initials: C
authors.lastname: Donnini
authors.forename: P P
authors.initials: PP
authors.lastname: Puglisi