title: Transepithelial ion transport across duct cells of the salivary gland.
abstract: Fluid and electrolyte secretions are vital for all epithelia and when aberrant lead to numerous pathophysiological conditions. Electrolyte transport across epithelia generates the osmotic force for fluid movement and is mediated by several membrane proteins expressed on both apical and basolateral poles of epithelial cells. Sodium and chloride are crucial for regulation of fluid secretion, thus regulating salivary volume. Bicarbonate (HCO3-), on the other hand, is the major pH buffer; hence, aberrant HCO3- secretion is a major factor in diseases such as cystic fibrosis (CF) causing altered mucin hydration and solubilization. Here, the structure-function mechanisms of the major membrane transporters involved in salivary duct electrolyte transport are reviewed focusing on transepithelial movement of Cl(-) and HCO3-.
authors.affiliation: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: E
authors.initials: E
authors.lastname: Ohana
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D026901:Membrane Transport Proteins / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D018987:Salivary Ducts / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D028021:Sodium-Potassium-Chloride Symporters / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D000076988:Sulfate Transporters
chemical_list: D020346:Aquaporins; D001639:Bicarbonates; D002712:Chlorides; D026901:Membrane Transport Proteins; D015221:Potassium Channels; C439529:SLC26A6 protein, human; D027982:Sodium-Bicarbonate Symporters; D017923:Sodium-Hydrogen Exchangers; D028021:Sodium-Potassium-Chloride Symporters; D000076988:Sulfate Transporters; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D000254:Sodium-Potassium-Exchanging ATPase
keywords: bicarbonate; duct; epithelia; salivary gland; secretion; transporters