title: Trifluoromethyl ketones: properties, preparation, and application.
abstract: Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA. nicholas.leadbeater@uconn.edu.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Kelly
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mercadante
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Leadbeater
mesh_terms: D000478:Alkylation; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry*; D005938:Glucocorticoids / Q000819:agonists / Q000378:metabolism; D054879:Halogenation; D007659:Ketones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D005938:Glucocorticoids; D007659:Ketones; D009942:Organometallic Compounds; D005461:Fluorine