title: Morphological and immunohistochemical criteria of tissue response to radiotherapy in rectal cancer.
abstract: OBJECTIVE
  Given the context that rectal tumours respond to a certain degree to radiotherapy, a necessity arises for estimating a tumour's capacity to react to radiation from the very moment of diagnostic biopsy.
  
  
  METHODS
  We have histologically and immunohistochemically analysed tissues coming from 52 patients with rectal adenocarcinomas.
  
  
  RESULTS
  Of the studied parameters, the ones presenting significant variation under radiotherapy in terms of statistics(p 0.05) were: colloid type (p=0.001), EGFR in the tumour(p=0.00045), EGFR in the normal epithelium (p=0.0017),VEGF in the tumour (p=0.0132) and VEGF in the tumour stroma (p=0.030).
  
  
  CONCLUSIONS
  Our study follows the same trends as the medical literature we have consulted regarding the variation of EGFR and VEGF with radiotherapy, and the distinct note of our study relies in the observation that normal stroma in case of rectal tumors also reacts to radiotherapy, sometimes more aggressively than the tumor itself, especially in which concerns the nerve and muscle fibers.
authors.forename: S
authors.initials: S
authors.lastname: Ionescu
authors.forename: E
authors.initials: E
authors.lastname: Brătucu
authors.forename: S
authors.initials: S
authors.lastname: Zurac
authors.forename: F
authors.initials: F
authors.lastname: Staniceanu
authors.forename: Tr
authors.initials: T
authors.lastname: Pătraşcu
authors.forename: Tr
authors.initials: T
authors.lastname: Burcoş
authors.forename: V
authors.initials: V
authors.lastname: Herlea
authors.forename: D
authors.initials: D
authors.lastname: Degeratu
authors.forename: I
authors.initials: I
authors.lastname: Popa
authors.forename: D
authors.initials: D
authors.lastname: Cristian
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D024862:Oxyphil Cells / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D066246:ErbB Receptors