title: Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies.
abstract: This study aims to investigate the effect of zearalenone supplementation on rat metabolism. Rats received biweekly intragastric administration of zearalenone mycotoxin (3 mg/kg body weight) for 2 weeks. Urine and plasma samples after zearalenone administration were analyzed by NMR-based metabolomics. Zearalenone exposure significantly elevated the plasma levels of glucose, lactate, N-acetyl glycoprotein, O-acetyl glycoprotein, and propionate but reduced the plasma levels of tyrosine, branched-chain amino acids, and choline metabolites. Zearalenone supplementation decreased the urine levels of butyrate, lactate, and nicotinate. However, it increased the urine levels of allantoin, choline, and N-methylnicotinamide at 0-8 h after the last zearalenone administration and those of 1-methylhistidine, acetoacetate, acetone, and indoxyl sulfate at 8-24 h after the last zearalenone administration. These results suggest that zearalenone exposure can cause oxidative stress and change common systemic metabolic processes, including cell membrane metabolism, protein biosynthesis, glycolysis, and gut microbiota metabolism.
authors.affiliation: Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu 611130, Sichuan, China.
authors.forename: Guangmang
authors.initials: G
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Huang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Jia
authors.forename: Caimei
authors.initials: C
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.forename: Bai
authors.initials: B
authors.lastname: Xue
authors.forename: Liang
authors.initials: L
authors.lastname: Xiao
authors.forename: Jiayong
authors.initials: J
authors.lastname: Tang
mesh_terms: D000818:Animals; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics; D010949:Plasma / Q000737:chemistry; D051381:Rats / Q000235:genetics / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D014556:Urine / Q000737:chemistry; D015025:Zearalenone / Q000378:metabolism / Q000633:toxicity*
chemical_list: D015025:Zearalenone