title: Molecular mimicry and original biochemical strategies for the biogenesis of a Legionella pneumophila replicative niche in phagocytic cells.
abstract: Legionella pneumophila is a paradigm of highly adapted intravacuolar pathogens that acquired the rare ability to replicate within a phagocytic cell. Here, we review recent progress about the role of Type 4 secretion system effectors involved in the biogenesis of the replicative niche, the Legionella containing vacuole.
authors.affiliation: CIRI, Centre for Infectiology Research, Legionella Pathogenesis Team, Université de Lyon, Lyon, France; Inserm, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; CNRS, UMR5308, Lyon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Allombert
authors.forename: Fabien
authors.initials: F
authors.lastname: Fuche
authors.forename: Céline
authors.initials: C
authors.lastname: Michard
authors.forename: Patricia
authors.initials: P
authors.lastname: Doublet
mesh_terms: D058947:Bacterial Secretion Systems / Q000502:physiology; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism / Q000382:microbiology; D016952:Legionella pneumophila / Q000502:physiology*; D007877:Legionnaires' Disease / Q000382:microbiology*; D018716:Molecular Mimicry; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism; D010586:Phagocytes / Q000382:microbiology*; D014617:Vacuoles / Q000378:metabolism
chemical_list: D058947:Bacterial Secretion Systems; D020559:Monomeric GTP-Binding Proteins
keywords: Host pathways subversion; Intravacuolar pathogen; Legionella containing vacuole; Type 4 secretion system effectors; Vesicular trafficking