title: [A short-term training program reduced acute phase proteins in premenopausal women with metabolic syndrome].
abstract: BACKGROUND
  It is accepted low grade systemic inflammation plays a key role in metabolic syndrome. Further, several studies have reported it may be considered a therapeutic target. Accordingly, this study was conducted to ascertain the impact of a short-term aerobic training program on acute phase proteins in women with metabolic syndrome.
  
  
  METHODS
  A total of 135 adult women (38.4 ± 3.3 years) with metabolic syndrome volunteered for this study. Participants assigned to the intervention group underwent a 12-week aerobic training program, 3 sessions/week. The main part of each exercise sessions was performed in a treadmill at moderate intensity (60- 75%HRmax; increasing 5% each 3 weeks) for 25-40 minutes (increasing 5 minutes each 3 weeks). Physical fitness was determined by a continuous maximal incremental test. Further, fat mass percentage and indices of obesity were assessed. Plasmatic levels of C reactive protein (CRP-us) and fibrinogen were determined by nephelometry and HPLC respectively. This protocol was approved by an Institutional Ethics Committee.
  
  
  RESULTS
  Aerobic training improved physical fitness and reduced both fat mass percentage and indices of obesity. Compared with baseline, it also reduced significantly plasmatic levels of CRP-us (4.90 ± 0.7 vs. 3.77 ± 0.4 mg/l; p = 0.017) and fibrinogen (3.88 ± 0.4 vs. 3.36 ± 0.2 g/l; p = 0.025). Further, a moderate correlation was found between CRP-us and waist circumference (r = 0.66; p = 0.008). No significant changes were found in controls.
  
  
  CONCLUSIONS
  A short-term, aerobic training program reduced acute phase proteins in young women with metabolic syndrome. Further, long-term, well-conducted studies are still required to determine whether correction of this low-grade inflammation improves clinical outcomes of women with metabolic syndrome.
authors.affiliation: Escuela de Medicina del Deporte. Universidad de Cádiz. Cádiz.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosety-Rodríguez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fornieles
authors.forename: Alejandra
authors.initials: A
authors.lastname: Camacho-Molina
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rosety
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Díaz
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rosety
authors.forename: Antonia
authors.initials: A
authors.lastname: Rodríguez-Pareja
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Ordonez
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000628:therapy*; D017697:Premenopause; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins