title: Cross-talk between site-specific transcription factors and DNA methylation states.
abstract: DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
authors.affiliation: From the Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 and.
authors.forename: Adam
authors.initials: A
authors.lastname: Blattler
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Farnham
mesh_terms: D000818:Animals; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D063185:Epigenetic Repression / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D059372:Nucleotide Motifs / Q000235:genetics; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors
keywords: DNA Methylation; DNA-binding Protein; Epigenetics; Gene Regulation; Transcription Factors