title: Identification of a novel HIV-1 circulating recombinant form (CRF62_BC) in western Yunnan of China.
abstract: We report here a novel HIV-1 circulating recombinant form (CRF62_BC) that was isolated from three epidemiologically unlinked individuals [one from an injecting drug user (IDU); two from heterosexuals] in Dehong prefecture of western Yunnan province. CRF62_BC harbored two subtype B segments in the pol and vpu-env regions in a subtype C backbone. Subregion tree analysis demonstrated that subtype B regions originated from a Thai-B (subtype B') lineage and the subtype C region was from an India C lineage. CRF62_BC is the fourth CRF composed of subtypes B' and C known to date after CRF07_BC, CRF08_BC, and CRF57_BC, which were originally found among IDUs in China. The emergence of CRF62_BC may indicate the continual generation of new recombinant strains in various high-risk populations in western Yunnan. This may complicate the development of effective vaccines to limit the HIV-1 epidemic and increase the difficulty of AIDS prevention and control in China.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China .
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.forename: Jenny
authors.initials: J
authors.lastname: His
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.forename: Song
authors.initials: S
authors.lastname: Duan
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Ning
authors.forename: Nidan
authors.initials: N
authors.lastname: Wang
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takebe
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000328:Adult; D002681:China; D016000:Cluster Analysis; D019143:Evolution, Molecular; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D012328:RNA Viruses / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral