title: Open loop optogenetic control of simulated cortical epileptiform activity.
abstract: We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage.
authors.affiliation: University of California, Berkeley, Berkeley, CA, 94704, USA, pselvaraj@berkeley.edu.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Selvaraj
authors.forename: Jamie W
authors.initials: JW
authors.lastname: Sleigh
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Freeman
authors.forename: Heidi E
authors.initials: HE
authors.lastname: Kirsch
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Szeri
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D062308:Optogenetics; D010775:Photic Stimulation; D012640:Seizures / Q000503:physiopathology*