title: An active, general, and long-lived palladium catalyst for cross-couplings of deactivated (hetero)aryl chlorides and bromides with arylboronic acids.
abstract: An active, general, and long-lived palladium catalyst for Suzuki-Miyaura reactions of aryl and heteroaryl chlorides deactivated by steric hindrance, electron richness, and coordinating functional groups is reported. In reactions of arylbromide bearing two o-tert-butyl substituents, C(sp(3))-H arylation of the tert-butyl group, rather than the Suzuki-Miyaura reaction, proceeded in excellent yield. The key to the success of the reactions was the development of biphenylene-substituted dicyclohexylruthenocenylphosphine (CyR-Phos) as a supporting ligand.
authors.affiliation: Department of Chemistry and Chemical Engineering, Niigata University , 8050, 2-Nocho, Ikarashi, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hoshi
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Honma
authors.forename: Ayako
authors.initials: A
authors.lastname: Mori
authors.forename: Maki
authors.initials: M
authors.lastname: Konishi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Hagiwara
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki