title: Age- and gender-associated changes in the concentrations of serum TGF-1β, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis).
abstract: Age-related changes in the concentration of factors like TGF-1β, DHEA-S and IGF-1 may increase the risk of disease and illnesses in advanced life. A better understanding of these changes would aid in the development of more appropriate treatments and/or preventative care for many conditions associated with age. Due to their similar immune system and vulnerability to pathogens, baboons are an ideal model for humans. However, little research has been done examining the general effects of age in baboons. Therefore, we wanted to further examine the effects of aging in baboons by determining the age-dependent changes in serum TGF-1β, DHEA-S and IGF-1 concentrations. Blood samples were collected during routine health checks in 113-118 captive baboons. In addition, longitudinal samples from 23 to 27 adult individuals were collected an average of 10.7years apart. Both age and gender influenced the concentrations of serum TGF-1β and IGF-1. When both genders were analyzed together, TGF-1β increased 16.1% as adults, compared to younger and older animals, but male and female baboons showed a slightly different temporal pattern of change. IGF-1 decreased with increasing age and males had a 30% greater concentration of IGF-1 than did females. While there was no effect of gender among our population, serum DHEA-S was negatively correlated with age, decreasing by 51.6% in the oldest animals. There were no effects of age or gender on serum IGFBP-3. In longitudinal samples collected from the same individuals, the concentrations of TGF-1β, DHEA-S and IGF-1 were reduced with age. The results presented herein provide additional knowledge of the aging process in baboons and further validate the use of this species as an appropriate model for aging in humans.
authors.affiliation: Department of Physiological Sciences, Center of Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. Electronic address: erin.willis@okstate.edu.
authors.forename: E L
authors.initials: EL
authors.lastname: Willis
authors.affiliation: Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: roman-wolf@ouhsc.edu.
authors.forename: R F
authors.initials: RF
authors.lastname: Wolf
authors.affiliation: Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: gary-white@ouhsc.edu.
authors.forename: G L
authors.initials: GL
authors.lastname: White
authors.affiliation: Department of Physiological Sciences, Center of Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. Electronic address: diannem@okstate.edu.
authors.forename: D
authors.initials: D
authors.lastname: McFarlane
mesh_terms: D000375:Aging; D000818:Animals; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007107:Immune System / Q000378:metabolism; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D048529:Papio hamadryas; D011863:Radioimmunoassay; D012737:Sex Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D053773:Transforming Growth Factor beta1; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I
keywords: Aging; Baboon; DHEA; DHEA-S; IGF-1; IGFBP-3; IL; Ig; Non-human primates; TGF-1β; dehydroepiandrosterone; dehydroepiandrosterone sulfate; immunoglobulin; insulin like growth factor binding protein-3; insulin like growth factor-1; interleukin; transforming growth factor-1β