title: Targeting metabolic scavenging in pancreatic cancer.
abstract: Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.
authors.affiliation: Authors' Affiliation: Department of Medicine, Weill Cornell Medical College, New York City, New York.
authors.forename: Costas A
authors.initials: CA
authors.lastname: Lyssiotis
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Cantley
mesh_terms: D000178:Acrylamides / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D009243:NAD / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D010880:Piperidines / Q000494:pharmacology*
chemical_list: D000178:Acrylamides; D000970:Antineoplastic Agents; C480543:N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide; D010880:Piperidines; D009243:NAD