title: 2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.
abstract: 2-Sulfonyl-oxetanes have been prepared, affording non-planar structures with desirable physicochemical properties for fragment based drug discovery. The oxetane motif was formed by an intramolecular C-C bond formation. The fragments were further functionalised via organometallic intermediates at the intact oxetane and aromatic rings.
authors.affiliation: Department of Chemistry Imperial College London, South Kensington, London SW7 2AZ, UK. j.bull@imperial.ac.uk.
authors.forename: Kate F
authors.initials: KF
authors.lastname: Morgan
authors.forename: Ian A
authors.initials: IA
authors.lastname: Hollingsworth
authors.forename: James A
authors.initials: JA
authors.lastname: Bull
mesh_terms: D015195:Drug Design; D055808:Drug Discovery; D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D054852:Small Molecule Libraries
chemical_list: D004988:Ethers, Cyclic; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D054852:Small Molecule Libraries; C005287:oxetane