title: A statistical model for QTL mapping in polysomic autotetraploids underlying double reduction.
abstract: As a group of economically important species, linkage mapping of polysomic autotetraploids, including potato, sugarcane and rose, is difficult to conduct due to their unique meiotic property of double reduction that allows sister chromatids to enter into the same gamete. We describe and assess a statistical model for mapping quantitative trait loci (QTLs) in polysomic autotetraploids. The model incorporates double reduction, built in the mixture model-based framework and implemented with the expectation-maximization algorithm. It allows the simultaneous estimation of QTL positions, QTL effects and the degree of double reduction as well as the assessment of the estimation precision of these parameters. We performed computer simulation to examine the statistical properties of the method and validate its use through analyzing real data in tetraploid switchgrass.
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.forename: Yafei
authors.initials: Y
authors.lastname: Lyu
authors.forename: Chunfa
authors.initials: C
authors.lastname: Tong
authors.forename: Weimiao
authors.initials: W
authors.lastname: Wu
authors.forename: Xuli
authors.initials: X
authors.lastname: Zhu
authors.forename: Danni
authors.initials: D
authors.lastname: Yin
authors.forename: Qin
authors.initials: Q
authors.lastname: Yan
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Pang
authors.forename: Christian M
authors.initials: CM
authors.lastname: Tobias
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D019295:Computational Biology; D003198:Computer Simulation; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D009010:Monte Carlo Method; D008897:Panicum / Q000235:genetics; D010944:Plants / Q000235:genetics; D011132:Polyribosomes / Q000235:genetics; D040641:Quantitative Trait Loci; D057891:Tetraploidy
keywords: EM algorithm; polysomic autotetraploid; quantitative genetic model; quantitative trait loci