title: Pallidotomy after chronic deep brain stimulation.
abstract: Recent publications have demonstrated that deep brain stimulation for Parkinson's disease still exerts beneficial effects on tremor, rigidity, and bradykinesia for up to 10 years after implantation of the stimulator. However with the progression of Parkinson's disease, features such as cognitive decline or "freezing" become prominent, and the presence of an implanted and functioning deep brain stimulator can impose a profound burden of care on the clinical team and family. The authors describe their experience in treating 4 patients who underwent removal of the implanted device due to either progressive dementia requiring full-time nursing or due to infection, and who subsequently underwent a unilateral pallidotomy.
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology Group, Nuffield Department of Surgery, University of Oxford, and Department of Neurological Surgery, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: Kristian J
authors.initials: KJ
authors.lastname: Bulluss
authors.forename: Erlick A
authors.initials: EA
authors.lastname: Pereira
authors.forename: Carole
authors.initials: C
authors.lastname: Joint
authors.forename: Tipu Z
authors.initials: TZ
authors.lastname: Aziz
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000209:etiology; D003131:Combined Modality Therapy; D046690:Deep Brain Stimulation; D020878:Device Removal; D018450:Disease Progression; D004567:Electrodes, Implanted / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053860:Pallidotomy; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology / Q000601:surgery / Q000628:therapy*; D011788:Quality of Life; D012189:Retrospective Studies; D016879:Salvage Therapy; D016896:Treatment Outcome; D014946:Wound Infection / Q000188:drug therapy / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D000978:Antiparkinson Agents