title: Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice.
abstract: This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. Mice were divided into five groups: group I: negative control; group II: positive control; group III: 0.3 mg/kg of DFB; group IV: 1 mg/kg of DFB; group V: 3 mg/kg DFB. Peripheral blood was collected for the comet assay and the micronucleus (MN) test. DFB increased incidence of comet formation at all doses tested. A rise in the frequency of MN in mouse peripheral blood was observed 24, 48, and 72 h postexposure at all doses tested. Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner.
authors.affiliation: a School of Health Sciences, Federal University of Grande Dourados (UFGD) , Dourados , Mato Grosso do Sul State , Brazil.
authors.forename: Aline Lima
authors.initials: AL
authors.lastname: de Barros
authors.forename: Vanessa Vilamaior
authors.initials: VV
authors.lastname: de Souza
authors.forename: Stephanie Dynczuki
authors.initials: SD
authors.lastname: Navarro
authors.forename: Silvia Aparecida
authors.initials: SA
authors.lastname: Oesterreich
authors.forename: Rodrigo Juliano
authors.initials: RJ
authors.lastname: Oliveira
authors.forename: Cândida Aparecida Leite
authors.initials: CA
authors.lastname: Kassuya
authors.forename: Arielle Cristina
authors.initials: AC
authors.lastname: Arena
mesh_terms: D000818:Animals; D020552:Comet Assay; D004132:Diflubenzuron / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*
chemical_list: D007306:Insecticides; D009153:Mutagens; D004132:Diflubenzuron