title: Exercise boosts hippocampal volume by preventing early age-related gray matter loss.
abstract: Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology.
authors.affiliation: RG Animal models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim (ZI), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Fuss
authors.forename: Sarah V
authors.initials: SV
authors.lastname: Biedermann
authors.forename: Claudia
authors.initials: C
authors.lastname: Falfán-Melgoza
authors.forename: Matthias K
authors.initials: MK
authors.lastname: Auer
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Jörg
authors.initials: J
authors.lastname: Steinle
authors.forename: Felix
authors.initials: F
authors.lastname: Hörner
authors.forename: Alexander
authors.initials: A
authors.lastname: Sartorius
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ende
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weber-Fahr
authors.forename: Peter
authors.initials: P
authors.lastname: Gass
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D016371:Cranial Irradiation / Q000009:adverse effects; D006624:Hippocampus / Q000473:pathology* / Q000528:radiation effects; D021621:Imaging, Three-Dimensional; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012420:Running
keywords: aging; brain matter; hippocampus; mice; sports; wheel running