title: Comparison of motor and sensory response of InterStim® for overactive bladder syndrome.
abstract: OBJECTIVE
  To determine the correlation of InterStim amplitudes required to evoke motor and sensory responses in subjects with overactive bladder (OAB) and to determine if subjects reprogrammed to achieve motor response have improvement in voiding diary parameters.
  
  
  METHODS
  Descriptive pilot study of patients with an existing sacral nerve stimulation (SNS) device for OAB. Subjects completed voiding diaries and reported subjective improvement at current settings. Subject's implantable pulse generator was interrogated while surface electromyography (EMG) was performed using a rectal sponge electrode. Electromyography was evaluated for baseline motor response demonstrated by compound muscle action potential (cMAP) at current settings. Stimulation amplitude was reduced to zero then incrementally increased. Amplitudes evoking subject sensation and motor response were recorded and used for correlation calculation. Subjects without baseline motor response were reprogrammed to achieve cMAP, and voiding diaries were completed after reprogramming.
  
  
  RESULTS
  Thirty-one subjects were recruited. Twelve (39%) had motor response (cMAP) at baseline settings. Subjects with motor response were significantly more likely to report sensation of stimulation versus those without (55% vs 17%; P = 0.04). Amplitudes evoking motor response were found to be significantly correlated to those for sensory response (r = 0.90; P < 0.0005). Sixteen of 19 subjects without baseline motor response were successfully reprogrammed to achieve cMAP. Improvements in nocturia, incontinence, and urgency incontinence episodes (14.4%, 19.8%, 18.2%; nonsignificant) were seen in the reprogrammed group.
  
  
  CONCLUSIONS
  Sacral nerve stimulation motor and sensory amplitudes were highly correlated in our cohort, and subjects with motor response were significantly more likely to feel sensation of stimulation. This supports the theory that both motor efferent and sensory afferent portions of the sacral nerve may contribute to SNS mechanism.
authors.affiliation: From the *Division of Urogynecology, Kaiser Permanente Orange County, Anaheim, CA; †Department of Medicine, and ‡Division of Urogynecology, University of California Irvine, Irvine, CA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lee
authors.forename: Kathryn
authors.initials: K
authors.lastname: Osann
authors.forename: Karen
authors.initials: K
authors.lastname: Noblett
mesh_terms: D000368:Aged; D004599:Electric Stimulation Therapy; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008875:Middle Aged; D012447:Sacrum / Q000294:innervation; D053201:Urinary Bladder, Overactive / Q000503:physiopathology* / Q000628:therapy*