title: Monoterpene indole alkaloids from the stem bark of Mitragyna diversifolia and their acetylcholine esterase inhibitory effects.
abstract: Five monoterpene indole alkaloids, mitradiversifoline, with a unique rearranged skeleton, specionoxeine-N(4)-oxide, 7-hydroxyisopaynantheine, 3-dehydropaynantheine, and 3-isopaynantheine-N(4)-oxide, and 10 known ones, were isolated from Mitragyna diversifolia. All the isolates were evaluated for their inhibition of acetylcholinesterase activities, and four showed moderate activities, with IC50 values of 4.1, 5.2, 10.2, and 10.3 μM, respectively.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
authors.forename: Xing-Fen
authors.initials: XF
authors.lastname: Cao
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D032065:Mitragyna / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D046948:Secologanin Tryptamine Alkaloids; D000110:Acetylcholinesterase
keywords: Acetylcholinesterase inhibition; Indole alkaloids; MALGMJVUNHCIIJ-KPWJTKAOSA-N; Mitragyna diversifolia; NNCQFOGYRMXDQB-NQHWVDMSSA-N; OJKYJWDFFASHGX-YOOCQZJISA-N; Rubiaceae; VJJLRVDUFIKWCM-LEKKXJIISA-O; WJALLKXSRQIWHF-ATOZLQQRSA-N