title: Copper-catalyzed three-component reaction: solvent-controlled regioselective synthesis of 4-amino- and 6-amino-2-iminopyridines.
abstract: Regioselective synthesis of multisubstituted 4-amino- and 6-amino-2-iminopyridines has been developed via the copper-catalyzed three-component reaction based on the reaction conditions selection. The reaction of sulfonyl azides, alkynes, and 2-[(amino)methylene]malononitriles catalyzed by copper(I) iodide in tetrahydrofuran at room temperature afforded substituted 4-amino-2-iminopyridines, whereas, in N,N-dimethylformamide at 50 °C under N2, it generated substituted 6-amino-2-iminopyridines as predominant products.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China, and School of Chemistry and Environmental Engineering, Changchun University of Science and Technology , Changchun 130022, China.
authors.forename: Fenguo
authors.initials: F
authors.lastname: Zhou
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Liang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Xin
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*
chemical_list: C587708:4-amino-2-iminopyridine; C587709:6-amino-2-iminopyridine; D009570:Nitriles; D011725:Pyridines; D012997:Solvents; D003300:Copper