title: A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study.
abstract: OBJECTIVE
  To prospectively investigate the effect of radiotherapy fraction size on clinical outcomes in early glottic carcinoma
  
  
  METHODS
  Patients with T1-2 glottic carcinoma were eligible for the protocol. Although 282 patients were required, the study was closed prematurely due to poor accrual with only 156 patients. Of these, 82 patients were allocated to conventional fractionation (CONV) arm (66 Gy/33 fractions for T1 and 70 Gy/35 fractions for T2), with 74 patients to hypofractionation (HYPO) arm (63 Gy/28 fractions for T1 and 67.5 Gy/30 fractions for T2). The primary objective was local progression-free survival (LPFS).
  
  
  RESULTS
  With a median follow-up of 67 months (range, 2-122 months), the 5-year LPFS was 77.8% for CONV arm and 88.5% for HYPO arm (HR 1.55, p=0.213). No significant difference was observed in the toxicity profile between the two arms. In a subgroup exploratory analysis for T1a disease, the 5-year LPFS trended positively in HYPO arm (76.7% vs. 93.0%, HR 3.65, p=0.056).
  
  
  CONCLUSIONS
  Given that HYPO is at least not inferior to CONV with a similar toxicity profile, the hypofractionation scheme used in this study can be offered to patients with T1-2 glottic carcinoma with potential advantages in terms of local control and a shortened overall treatment time.
authors.affiliation: Research Institute and Hospital, National Cancer Center, Republic of Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Moon
authors.affiliation: Research Institute and Hospital, National Cancer Center, Republic of Korea. Electronic address: kwancho@ncc.re.kr.
authors.forename: Kwan Ho
authors.initials: KH
authors.lastname: Cho
authors.affiliation: National Health Insurance Service, Ilsan Hospital, Republic of Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Chung
authors.affiliation: Yonsei University College of Medicine, Republic of Korea.
authors.forename: Chang Geol
authors.initials: CG
authors.lastname: Lee
authors.affiliation: Gachon University Gil Medical Center, Republic of Korea.
authors.forename: Kyu Chan
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Gyeongsang National University Hospital, Republic of Korea.
authors.forename: Gyu-Young
authors.initials: GY
authors.lastname: Chai
authors.affiliation: Gyeongsang National University Hospital, Republic of Korea.
authors.forename: Ki Mun
authors.initials: KM
authors.lastname: Kang
authors.affiliation: Wonju Severance Christian Hospital, Republic of Korea.
authors.forename: Jong Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Chonnam National University College of Medicine, Republic of Korea.
authors.forename: Woong-Ki
authors.initials: WK
authors.lastname: Chung
authors.affiliation: Chungbuk National University Hospital, Republic of Korea.
authors.forename: Woo Yoon
authors.initials: WY
authors.lastname: Park
authors.affiliation: Keimyung University Dongsan Medical Center, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D005931:Glottis / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Fraction size; Glottic carcinoma; Hypofractionation; Radiotherapy