title: Natural products that inhibit carbonic anhydrase.
abstract: The chemical diversity, binding specificity and propensity to interact with biological targets has inspired many researchers to utilize natural products as molecular probes. Almost all reported carbonic anhydrase inhibitors comprise a zinc binding group in their structure of which the primary sulfonamide moiety (-SO2NH2) is the foremost example and to a lesser extent the primary sulfamate (-O-SO2NH2) and sulfamide (-NH-SO2NH2) groups. Natural products that comprise these zinc binding groups in their structure are however rare and relatively few natural products have been explored as a source for novel carbonic anhydrase inhibitors. This chapter will highlight the recent and growing interest in carbonic anhydrase inhibitors sourced from nature, demonstrating that natural product chemical space presents a rich source of potential alternate chemotypes for the discovery of novel drug-like carbonic anhydrase inhibitors.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia, s.poulsen@griffith.edu.au.
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Poulsen
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D002256:Carbonic Anhydrases / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D019800:Phenol / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D001688:Biological Products; D002257:Carbonic Anhydrase Inhibitors; D003374:Coumarins; D011073:Polyamines; D013449:Sulfonamides; D013451:Sulfonic Acids; D019800:Phenol; C005741:sulfamic acid; D002256:Carbonic Anhydrases