title: N-substituted Indole-2 and 3-carboxamide derivatives as inhibitors of human protein kinase CK2: in vitro assay and molecular modelling study.
abstract: Protein kinase CK2 (Casein Kinase 2) is involved in cell growth; proliferation and suppression of apoptosis. Hence, it strongly promotes cell survival and can be considered an important target for human cancers. In the present study, a series of N-substituted indole-2- and 3-carboxamide derivatives were tested for inhibitions of human recombinant protein kinase CK2 to evaluate their anticancer properties. The inhibition test revealed that the most active compound 4 (1-benzyl-N-(2,4-dichlorobenzyl)-1H-indole-2-carboxamide) showed an IC50 value of 14.6 µM towards human protein kinase CK2. A molecular docking study of the compounds with CK2 was performed and revealed the binding mode of the most active compound 4, underlying its inhibitory activity.
authors.forename: Süreyya
authors.initials: S
authors.lastname: Olgen
authors.forename: Andreas
authors.initials: A
authors.lastname: Gratz
authors.forename: Zühal Kılıç
authors.initials: ZK
authors.lastname: Kurt
authors.forename: Joachim
authors.initials: J
authors.lastname: Jose
mesh_terms: D047390:Casein Kinase II / Q000037:antagonists & inhibitors*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008958:Models, Molecular; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011994:Recombinant Proteins; D013329:Structure-Activity Relationship
chemical_list: C584609:1-benzyl-N-(2,4-dichlorobenzyl)-1H-indole-2-carboxamide; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011994:Recombinant Proteins; D047390:Casein Kinase II