title: Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L.
abstract: As the traditional Chinese medicine, the fresh fruits of Amorpha fruticosa L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of Amorpha fruticosa L. during wound healing progress. In the present study, we evaluated both antimicrobial potential against a wide range of microorganisms and wound healing activity of the seven compounds isolated from the fruits of Amorpha fruticosa L in vitro and in vivo. Our results showed that compounds I (6a,12a-dehydroamorphin), V (dehydrosermundone) and VI (tephrosin) isolated from the fruits of Amorpha fruticosa L. performed dominant antimicrobial potential against microorganisms. Moreover, these compounds significantly enhanced fibroblasts proliferation and migration, leading to promotion of wound healing. Thus, it could be possible for the therapeutic utilization of Amorpha fruticosa L. for wound healing in the future.
authors.affiliation: Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning Province, China 116011.
authors.forename: Xueling
authors.initials: X
authors.lastname: Qu
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Diao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shouyu
authors.initials: S
authors.lastname: Wang
authors.forename: Yujie
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007887:Fabaceae / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit; D008297:Male; D051379:Mice; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012402:Rotenone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000382:microbiology*
chemical_list: C588409:6a,12a-dehydroamorphin; D000900:Anti-Bacterial Agents; D005419:Flavonoids; D028321:Plant Preparations; C588410:dehydrosermundone; D012402:Rotenone; C480848:tephrosin
keywords: Amorpha fruticosa L.; anti-bacterial; wound healing