title: The case of a patient affected by primary gliosarcoma and neuroendocrine pancreatic cancer with prolonged survival.
abstract: Primary gliosarcoma (PGS) is a rare neoplasm with a poor prognosis. It is considered as a variant of glioblastoma multiforme (GBM) and as a grade IV neoplasm. There is little evidence on the optimal therapy for this disease: treatment of PGS includes surgery, radiotherapy and chemotherapy, and often the same treatment used for GBM is employed for PGS. Several studies have demonstrated that somatostatin receptors are overexpressed in gliomas; somatostatin analogues could therefore also be employed in this mixed form but to date the experience reported in the literature is unclear and there are no studies about the use of these agents in PGS. We present the case of a patient affected by both PGS and neuroendocrine pancreatic cancer. The case is interesting for the prolonged survival and for the stabilization of disease obtained during therapy with somatostatin analogues.
authors.forename: Marianna
authors.initials: M
authors.lastname: Trignani
authors.forename: Maria
authors.initials: M
authors.lastname: Taraborrelli
authors.forename: Giampiero
authors.initials: G
authors.lastname: Ausili Cèfaro
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D004334:Drug Administration Schedule; D018316:Gliosarcoma / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000628:therapy; D015282:Octreotide / Q000008:administration & dosage*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000628:therapy; D049268:Positron-Emission Tomography; D017741:Survivors; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide