title: [MRI for monitoring of high intensity focused ultrasound: current developments].
abstract: With respect to monitoring of high intensity focused ultrasound (HIFU), synonym focused ultrasound (FUS) treatment, magnetic resonance imaging (MRI) is characterized by several advantageous properties: the precise definition and morphological characterization of the target area (before and after the intervention), the real-time visualization of the treatment effect by thermal imaging (during the intervention) and in the sense of a stereotactic system, the 3-dimensional localization of the target lesion, planning of the target volume and assessment of the achieved ablation volume (before and during the intervention). Non-enhanced T2-weighted multislice MR images are acquired for planning of the intervention. For temperature monitoring (comprising thermometry and thermodosimetry), the temperature-dependent shift of proton resonance frequency (PRFS) is most frequently employed. This method is independent of the treated tissue type or thermally induced tissue changes and facilitates a relative measurement of the temperature change based on a reference value. Future MRI applications include diffusion-weighted MRI (DWI-MRI; for the intrainterventional estimation of treatment efficacy), dynamic contrast-enhanced MRI (DCE-MRI, for the prediction of the potential and assessment of the treatment effect achieved) and motion-corrected temperature monitoring (referenceless and multibaseline thermometry).
authors.affiliation: Institut für Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universität München, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland, christoph.trumm@med.lmu.de.
authors.forename: C G
authors.initials: CG
authors.lastname: Trumm
authors.forename: R
authors.initials: R
authors.lastname: Stahl
authors.forename: M
authors.initials: M
authors.lastname: Peller
authors.forename: D-A
authors.initials: DA
authors.lastname: Clevert
authors.forename: A
authors.initials: A
authors.lastname: Huber
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
authors.forename: M
authors.initials: M
authors.lastname: Matzko
mesh_terms: D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D016343:Monitoring, Intraoperative / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*