title: The chemokine receptor 5 delta32 polymorphism and type 1 diabetes, Behcet's disease, and asthma: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to type 1 diabetes (T1D), Behcet's disease (BD), and asthma.
  
  
  RESULTS
  Fourteen studies encompassing 9,656 cases and 12,431 controls, including 6 on T1D, 5 on BD, and 3 on asthma, were available for meta-analysis. The meta-analysis showed a significant negative association between T1D and the CCR5-Δ32 allele (odds ratio [OR] = 0.854, 95% confidence interval [CI] = 0.800-0.912, p = 2.2 × 10⁻⁷). Stratification by ethnicity and analysis of the Δ32Δ32 + Δ32W genotype indicated a significant negative association between the CCR5-Δ32 allele and T1D in Europeans (OR = 0.857, 95% CI = 0.802-0.915, p = 3.5 × 10⁻⁸; OR = 0.896, 95% CI = 0.808-0.932, p = 9.3 × 10⁻⁶, respectively). The meta-analysis showed a positive association between BD and the Δ32Δ32 + Δ32W genotype (OR = 1.403, 95% CI = 1.008-1.954, p = 0.045). Stratification by HLA-B51 status indicated an association between the CCR5-Δ32 allele and HLA-B51-positive BD, but not HLA-B51-negative BD (OR = 1.619, 95% CI = 1.070-2.451, p = 0.023; OR = 1.036, 95% CI = 0.674-1.593, p = 0.872, respectively). No association was found between the CCR5-Δ32 polymorphism and asthma.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the CCR5-Δ32 polymorphism acts as a protective factor in T1D development in Europeans, and a risk factor for BD among HLA-B51 carriers. However, no association was found between the CCR5-Δ32 polymorphism and asthma.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000483:Alleles; D001249:Asthma / Q000235:genetics / Q000378:metabolism*; D001528:Behcet Syndrome / Q000235:genetics / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059949:HLA-B51 Antigen / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D012306:Risk; D017384:Sequence Deletion / Q000235:genetics; D044465:White People
chemical_list: D059949:HLA-B51 Antigen; D019713:Receptors, CCR5