title: Effect of repeated compaction of tablets on tablet properties and work of compaction using an instrumented laboratory tablet press.
abstract: The repeated compaction of Avicel PH101, dicalcium phosphate dihydrate (DCP) powder, 50:50 DCP/Avicel PH101 and Starch 1500 was studied using an instrumented laboratory tablet press which measures upper punch force, punch displacement and ejection force and operates using a V-shaped compression profile. The measurement of work compaction was demonstrated, and the test materials were ranked in order of compaction behaviour Avicel PH101 > DCP/Avicel PH101 > Starch > DCP. The behaviour of the DCP/Avicel PH101 mixture was distinctly non-linear compared with the pure components. Repeated compaction and precompression had no effect on the tensile fracture strength of Avicel PH101 tablets, although small effects on friability and disintegration time were seen. Repeated compaction and precompression reduced the tensile strength and the increased disintegration time of the DCP tablets, but improved the strength and friability of Starch 1500 tablets. Based on the data reported, routine laboratory measurement of tablet work of compaction may have potential as a critical quality attribute of a powder blend for compression. The instrumented press was suitable for student use with minimal supervisor input.
authors.affiliation: Gamlen Tableting Ltd , Biocity Nottingham, Nottingham , UK .
authors.forename: Michael John Desmond
authors.initials: MJ
authors.lastname: Gamlen
authors.forename: Luigi G
authors.initials: LG
authors.lastname: Martini
authors.forename: Kais G
authors.initials: KG
authors.lastname: Al Obaidy
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods; D013607:Tablets / Q000032:analysis / Q000737:chemistry*
chemical_list: D013607:Tablets
keywords: Dicalcium phosphate dehydrate; friability; microcrystalline cellulose; precompression; tabletability