title: TMEM16A/B associated CaCC: structural and functional insights.
abstract: Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence，the reorganization of Ca(2+)-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.
authors.forename: Chunli
authors.initials: C
authors.lastname: Pang
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yuan
authors.forename: Shuxi
authors.initials: S
authors.lastname: Ren
authors.forename: Yafei
authors.initials: Y
authors.lastname: Chen
authors.forename: Hailong
authors.initials: H
authors.lastname: An
authors.affiliation: Institute of Biophysics, School of Science, Hebei University of Technology, 5340 Xiping Road, Beichen District, Tianjin, China, 300401. zhany@hebut.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhan
mesh_terms: D000595:Amino Acid Sequence; D000075369:Anoctamin-1; D000075368:Anoctamins; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin; D018118:Chloride Channels / Q000502:physiology*; D006801:Humans; D017136:Ion Transport / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology*; D017433:Protein Structure, Secondary; D016415:Sequence Alignment; D013329:Structure-Activity Relationship
chemical_list: C476213:ANO1 protein, human; C521849:ANO2 protein, human; D000075369:Anoctamin-1; D000075368:Anoctamins; D002147:Calmodulin; D018118:Chloride Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D002118:Calcium