title: Tumor localization using magnetic nanoparticle-induced acoustic signals.
abstract: Cancer is a major public health problem worldwide, especially in developed countries. Early detection of cancer can greatly increase both survival rates and quality of life for patients. A magnetoacoustic-based method had been previously proposed for early tumor detection, in a minimal invasive procedure, using magnetic nanoparticles (MNPs). This paper presents a supporting localization algorithm that can provide the clinician with essential tumor location data and could enable a sequential biopsy. It provides localization algorithm development, as well as its validation in both computerized simulations and in vitro experiments. Three-dimensional (3-D) tumor localization is demonstrated with an error of 2.14 mm and an overlapping volume of 84% of the actual tumor. The obtained results are promising and prove the feasibility of tumor localization using a time difference of arrival algorithm along with a magnetoacoustic detection scheme.
authors.forename: A
authors.initials: A
authors.lastname: Tsalach
authors.forename: I
authors.initials: I
authors.lastname: Steinberg
authors.forename: I
authors.initials: I
authors.lastname: Gannot
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D000465:Algorithms; D003198:Computer Simulation; D004867:Equipment Design; D021621:Imaging, Three-Dimensional / Q000379:methods*; D058185:Magnetite Nanoparticles; D008954:Models, Biological; D009369:Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D019047:Phantoms, Imaging
chemical_list: D058185:Magnetite Nanoparticles