title: Effect of octanal on the mycelial growth of Penicillium italicum and P. digitatum.
abstract: The present study investigated the antifungal activity of octanal against Penicillium italicum and P. digitatum. Results showed that octanal exhibited strong antifungal activity against the test pathogens in a dose-dependent manner. Scanning electron microscopy observation revealed that octanal obviously altered the morphology of P. italicum and P. digitatum hyphae by causing the loss of cytoplasm and distortion of mycelia. A rapid increase in the membrane permeability of P. italicum and P. digitatum was observed after treated with octanal at minimum inhibitory concentration or minimum fungicidal concentration, evidenced by the release of cell constituents, the extracellular conductivity and the extracellular potential of hydrogen. In addition, octanal apparently induced a decrease in total lipid contents of P. italicum and P. digitatum cells. These results suggested that the antifungal activity of octanal against P. italicum and P. digitatum can be attributed to the disruption of the cell membrane integrity and the leakage of cell components.
authors.affiliation: School of Chemical Engineering, Xiangtan University, Xiangtan, 411105, People's Republic of China, nengguotao@126.com.
authors.forename: Nengguo
authors.initials: N
authors.lastname: Tao
authors.forename: Lei
authors.initials: L
authors.lastname: Jia
authors.forename: Haien
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiangli
authors.initials: X
authors.lastname: He
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D025282:Mycelium / Q000187:drug effects* / Q000254:growth & development* / Q000648:ultrastructure; D010407:Penicillium / Q000187:drug effects* / Q000254:growth & development* / Q000648:ultrastructure; D010539:Permeability / Q000187:drug effects
chemical_list: D000447:Aldehydes; D000935:Antifungal Agents; C031639:caprylic aldehyde