title: Tumor shrinkage and improved quality of life in a heavily pretreated metastatic breast cancer patient treated with eribulin.
abstract: Eribulin mesylate is approved for the treatment of metastatic breast cancer after progression with anthracyclines and taxanes. Here we report the case of a woman with triple-negative breast cancer who, after nine lines of chemotherapy, showed striking primary tumor shrinkage and regression of metastatic lesions with eribulin treatment. This response allowed the patient to undergo debulking surgery. Even though the patient was heavily pretreated, eribulin was well tolerated and improved her quality of life. Biological analysis of tumor specimens was performed to investigate the underlying mechanism of action of the drug.
authors.affiliation: Azienda Ospedaliera Fatebenefratelli e Oftalmico, Department of Oncology, Corso di Porta Nuova 23, 20121 Milan, Italy.
authors.forename: Nicla
authors.initials: N
authors.lastname: La Verde
authors.forename: Sheila
authors.initials: S
authors.lastname: Piva
authors.forename: Monica
authors.initials: M
authors.lastname: Ganzinelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Farina
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gherardi
authors.forename: Serena
authors.initials: S
authors.lastname: Girelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Bramati
authors.forename: Luca
authors.initials: L
authors.lastname: Del Re
authors.forename: Giovanna
authors.initials: G
authors.lastname: Damia
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D006801:Humans; D007659:Ketones / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy; D011788:Quality of Life; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides