title: Small bowel obstruction caused by a large B-cell lymphoma in a patient with multicentric Castleman's disease: An unusual occurrence.
abstract: Multicentric Castleman's disease is a rare condition of systemic nonclonal lymph node hyperplasia. Because of its strong association with human herpes virus 8 (HHV8), the multicentric, more aggressive, form may progress to Kaposi sarcoma or non-Hodgkin lymphoma. While surgery is curative in the treatment of localized Castleman's disease, operative treatment of the diffuse form has as yet been unsatisfactory. We report the case of a patient presenting with postprandial vomiting of 1 month duration consistent with partial small bowel obstruction secondary to terminal ileum intussusception. Resection of the small bowel showed a stenosing tumor triggering the intussusception. On pathological examination, the tumor was found to be composed of HHV8-positive plasmablastic lymphoma cells. To our knowledge, this represents the first case of a complication due to the progression of multicentric Castleman's disease requiring surgical intervention for intussusception.
authors.affiliation: University of Bologna, Bologna, Italy isacmontroni@yahoo.com.
authors.forename: Isacco
authors.initials: I
authors.lastname: Montroni
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Sabattini
authors.affiliation: Bonn University School of Medicine, Bonn, Germany.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ramadori
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Vidak
authors.initials: V
authors.lastname: Koprivica
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Ugolini
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Locatelli
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Ghignone
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Rosati
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Taffurelli
authors.affiliation: University of Bologna, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pileri
mesh_terms: D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged
keywords: human herpes virus 8; intussusception; large B-cell lymphoma; multicentric Castleman’s disease; small bowel obstruction