title: Apolipoprotein E derived peptides inhibit the pro-inflammatory effect of lysophosphatidylcholine.
abstract: Apolipoprotein-derived peptides have emerged as a potential candidate for the treatment of various inflammatory disease conditions. These peptides bind to pro-inflammatory lipids and inhibit their inflammatory functions. Lysophosphatidylcholine (LPC) is a potent pro-inflammatory lipid and increased level of circulating LPC plays a major role in various acute and chronic inflammatory conditions. In this report we examined the effect of peptides derived from the C-terminal domain of human apolipoprotein E on the properties of LPC. Our results show that the peptides (E8, E10 and E11) bind to LPC and inhibit LPC-induced up-regulation of pro-inflammatory markers in human leukocytes. The results suggest that these peptides can be used as an anti-inflammatory agent in inflammatory conditions in which increased level of LPC is a culprit.
authors.forename: Sunil A
authors.initials: SA
authors.lastname: Nankar
authors.forename: Jitendra S
authors.initials: JS
authors.lastname: Prajapati
authors.affiliation: Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, (Mohali)-160 062, Punjab, India. apande@niper.ac.in.
authors.forename: Abhay H
authors.initials: AH
authors.lastname: Pande
mesh_terms: D000595:Amino Acid Sequence; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001057:Apolipoproteins E / Q000737:chemistry*; D002021:Buffers; D016207:Cytokines / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D017382:Reactive Oxygen Species / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D001057:Apolipoproteins E; D002021:Buffers; D016207:Cytokines; D008244:Lysophosphatidylcholines; D010446:Peptide Fragments; D017382:Reactive Oxygen Species