title: Concordance between core needle biopsy and surgical excision specimens for tumour hormone receptor profiling according to the 2011 St. Gallen Classification, in clinical practice.
abstract: To focus on and compare the tumor hormone receptor profiles on core needle biopsy (CNB) and subsequent surgical excision specimens in a large clinical series of invasive breast carcinoma patients, with regard to guidelines proposed at the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. A total of 993 consecutive patients who had hormone receptors (HR) assays performed on both CNB and subsequent surgical excision specimens of invasive carcinomas were included (1,110 tumors). Concordant tumor HR profiles between CNB and surgical excision specimens were noted in 1,085 of 1,110 tumors (97.75%). Among 138 tumors considered negative on CNB (both HR assays <1%), 10 cases (7.2%) displayed an HR profile positive on surgical excision specimen. Discrepancies between CNBs and surgical excision specimens are very seldom noted. HR assay evaluation on surgical excision specimens should only be considered in patients when both HR assays are negative on CNBs.
authors.affiliation: Department of Imaging, Department of Gynecology, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Loubeyre
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bodmer
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Tille
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Egger
authors.forename: Sophie
authors.initials: S
authors.lastname: Diebold-Berger
authors.forename: Michele
authors.initials: M
authors.lastname: Copercini
authors.forename: Alexandre
authors.initials: A
authors.lastname: Rozenholc
authors.forename: Patrick
authors.initials: P
authors.lastname: Petignat
authors.forename: Monica
authors.initials: M
authors.lastname: Castiglione
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062005:Biopsy, Large-Core Needle / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: CNB; St. Gallen Consensus; breast carcinoma; hormone receptor profile