title: Antimicrobial peptides incorporating non-natural amino acids as agents for plant protection.
abstract: The control of plant pathogens is mainly based on copper compounds and antibiotics. However, the use of these compounds has some limitations. They have a high environmental impact and the use of antibiotics is not allowed in several countries. Moreover, resistance has been developed to these pathogens. The identification of new agents able to fight plant pathogenic bacteria and fungi will represent an alternative to currently used antibiotics or pesticides. Antimicrobial peptides are widely recognized as promising candidates, however naturally occurring sequences present drawbacks that limit their development. These include susceptibility to protease degradation and low bioavailability. To overcome these problems, research has focused on the introduction of unnatural amino acids into lead peptide sequences. In particular, we have improved the biological profile of antimicrobial peptides active against plant pathogenic bacteria and fungi by incorporating triazolyl, biaryl and D-amino acids into their sequence. These modifications and their influence on the biological activity are summarized.
authors.forename: Iteng
authors.initials: I
authors.lastname: Ng-Choi
authors.forename: Marta
authors.initials: M
authors.lastname: Soler
authors.forename: Imma
authors.initials: I
authors.lastname: Güell
authors.forename: Esther
authors.initials: E
authors.lastname: Badosa
authors.forename: Jordi
authors.initials: J
authors.lastname: Cabrefiga
authors.forename: Eduard
authors.initials: E
authors.lastname: Bardaji
authors.forename: Emilio
authors.initials: E
authors.lastname: Montesinos
authors.forename: Marta
authors.initials: M
authors.lastname: Planas
authors.affiliation: LIPPSO, Department of Chemistry, University of Girona, Campus Montilivi, 17071 Girona, Spain. lidia.feliu@udg.edu.
authors.forename: Lidia
authors.initials: L
authors.lastname: Feliu
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D057786:Peptidomimetics / Q000737:chemistry / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology* / Q000628:therapy*; D010944:Plants / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents; D010455:Peptides; D057786:Peptidomimetics