title: Immunoglobulin G4-related sclerosing disease with orbital inflammation in a 12-year-old girl.
abstract: Immunoglobulin G4-related sclerosing disease is a rare but potentially debilitating cause of orbital inflammation, with a predilection for older males. We report the case of a 12-year-old African girl with immunoglobulin G4-related sclerosing disease, including possible extraorbital involvement. Because of an escalating severity of illness leading to oculomotor nerve palsy and cavernous sinus thrombosis that was resistant to steroids, systemic immunosuppressive therapy with rituximab was used to achieve disease remission. The diagnosis was histologically confirmed with a tissue biopsy.
authors.affiliation: Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York. Electronic address: monasanek@yahoo.com.
authors.forename: Mona
authors.initials: M
authors.lastname: Sane
authors.forename: James
authors.initials: J
authors.lastname: Chelnis
authors.forename: Rafal
authors.initials: R
authors.lastname: Kozielski
authors.forename: Airaj
authors.initials: A
authors.lastname: Fasiuddin
mesh_terms: D020226:Cavernous Sinus Thrombosis / Q000175:diagnosis*; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D015840:Oculomotor Nerve Diseases / Q000175:diagnosis*; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G