title: Escaping the immune system: How the malaria parasite makes vaccine development a challenge.
abstract: Malaria is a major cause of morbidity and mortality. Immunity is acquired but is suboptimal, being slow to develop and incomplete. An inadequate understanding of natural immunity, host-parasite interactions, and a lack of reliable immune correlates of protection that could predict vaccine efficacy in the field have hindered development of a vaccine. With data from Phase III trials indicating that the leading malaria vaccine candidate, RTS,S, has limited efficacy, it is necessary to reconsider approaches to the development of a vaccine capable of inducing long-lived protection.
authors.affiliation: Institute for Glycomics, Griffith University, Gold Coast Campus, Parklands Drive, Southport, Queensland, 4222, Australia. Electronic address: d.stanisic@griffith.edu.au.
authors.forename: Danielle I
authors.initials: DI
authors.lastname: Stanisic
authors.forename: Alyssa E
authors.initials: AE
authors.lastname: Barry
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000469:parasitology*; D008288:Malaria / Q000276:immunology*; D017780:Malaria Vaccines / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology
chemical_list: D017780:Malaria Vaccines
keywords: immune evasion; immunity; immunomodulation; malaria; vaccine