title: A double blind study on the efficacy of local application of hemocoagulase solution in wound healing.
abstract: OBJECTIVE
  The present double blind study has been designed to evaluate the efficacy of local application of hemocoagulase solution as compared to a placebo in wound healing following dental extraction.
  
  
  METHODS
  A total of 20 patients who required dental extraction for orthodontic intervention were included. The hemocoagulase solution and a placebo were locally applied to the extraction sockets and the efficacy of the solution in terms of bleeding control, anti-inflammatory responses, its antiseptic properties and efficacy in wound healing were evaluated.
  
  
  RESULTS
  The mean time required to achieve hemostasis was found to be 1.37 minutes in side A (test) and 2.33 minutes in side B (control) indicating that side A achieved faster hemostasis when compared to side B. At the 6th hour postoperatively, bleeding was not evident on either sides, and the amount of pain in side A was found to be less compared to side B. The number of RBCs, polymorphs, chronic inflammatory cells were not different in both the groups, whereas at 3rd postoperative day epithelial cells were greater in side A (test) compared to side B (control). Biopsy reports on the 12th postoperative day indicated that the number of fibroblasts, epithelial cells, collagen count was found to be greater in side A (test) compared to side B (control).
  
  
  CONCLUSIONS
  The topical hemocoagulase solution may be advocated in the field of oral and maxillofacial surgery, as a hemostatic agent and promoter of wound healing. However, further studies, with large number of cases and different clinical situations should be considered to authenticate the efficacy of this hemocoagulase solution in the practice of oral and maxillofacial surgery.
  
  
  CONCLUSIONS
  Wound healing plays an important role in the success of any surgical procedure, such as extractions, and the hemocoagulase system may act as a hemostatic agent and a promoter of wound healing.
authors.affiliation: Reader, Department of Oral Surgery, MES Dental College, Malappuram Kerala, India, e-mail: drsachinaslama@gmail.com.
authors.forename: Sachin
authors.initials: S
authors.lastname: Aslam
authors.forename: P G
authors.initials: PG
authors.lastname: Francis
authors.forename: B H S
authors.initials: BH
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Ummar
authors.forename: J K
authors.initials: JK
authors.lastname: Issac
authors.forename: R B
authors.initials: RB
authors.lastname: Nair
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D012103:Batroxobin / Q000627:therapeutic use*; D002452:Cell Count; D003094:Collagen / Q000187:drug effects; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D006472:Oral Hemorrhage / Q000517:prevention & control; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D010919:Placebos; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects*; D016896:Treatment Outcome; D014914:Whole Blood Coagulation Time; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D006490:Hemostatics; D010919:Placebos; D003094:Collagen; D012103:Batroxobin