title: Evaluation of short stature in children.
abstract: Normal growth in children is a reflection of general health and is the result of a complex interaction between genetic, nutritional, and hormonal factors. From conception through infancy, growth is mostly driven by maternal nutrition and the in utero environment. Genetic factors, growth and thyroid hormones, ghrelin, and sex steroids have a more prominent influence later. Normal growth is not linear; it is marked by periods of growth spurts, particularly during puberty, separated by periods of slow or immeasurable growth. There is often a period of growth deceleration observed before the onset of puberty, with maximal pubertal growth spurts occurring at Tanner stage III for girls and Tanner stage IV for boys. This is caused primarily by the combined effect of the increased amplitude of growth hormone pulses and sex steroids. Short stature (SS), which is the subject of this review, is defined as a length or height more than 2 standard deviations below the mean for age and gender, which corresponds to a percentile below 2.5%. Taking a thorough patient history and completing a comprehensive physical examination are some of the most important diagnostic tools for pediatricians to use in the diagnosis of SS, and in making appropriate referrals as needed.
authors.forename: Heba
authors.initials: H
authors.lastname: Ismail
authors.forename: Kathryn
authors.initials: K
authors.lastname: Ness
mesh_terms: D001827:Body Height; D002648:Child; D002657:Child Development; D003937:Diagnosis, Differential; D005260:Female; D057238:Growth Charts; D006130:Growth Disorders / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male