title: Development of novel treatment options for patients with haemophilia.
abstract: Treatment of haemophilia has vastly improved over the last years, but many needs are still unmet. Baxter is continuously pursuing the aim to provide new therapeutic options to patients with haemophilia and to their treating physicians. In fact, there are several opportunities to improve existing therapies, e.g., by new indications for existing products, the introduction of new products, and by novel therapeutic approaches other than factor replacement. Among these, Baxter is working on a number of innovations, such as pharmacokinetics-tailored factor VIII prophylaxis, bypassing agent prophylaxis with FEIBA in inhibitor patients, development of a longer acting pegylated recombinant FVIII, a new recombinant factor IX, a new recombinant factor FVIIa, the first recombinant von Willebrand factor, recombinant ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) as well as gene therapy to cure haemophilia B.
  
  
  CONCLUSIONS
  Baxter is truly committed to the benefit for the patient, and therefore engaged in providing a more and more individualized treatment, in increasing efficiency of current products, in developing new products and new approaches with added value.
authors.affiliation: Prof. Dr. Armin Reininger, Baxter Innovations GmbH, Industriestraße 67, 1220 Vienna, Austria, E-mail: armin_reininger@baxter.com.
authors.forename: H J
authors.initials: HJ
authors.lastname: Ehrlich
authors.forename: W Y
authors.initials: WY
authors.lastname: Wong
authors.forename: B M
authors.initials: BM
authors.lastname: Ewenstein
authors.forename: M
authors.initials: M
authors.lastname: Dockal
authors.forename: P L
authors.initials: PL
authors.lastname: Turecek
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
authors.forename: H
authors.initials: H
authors.lastname: Chehadeh
authors.forename: A
authors.initials: A
authors.lastname: Löw-Baselli
authors.forename: F
authors.initials: F
authors.lastname: Scheiflinger
authors.forename: A J
authors.initials: AJ
authors.lastname: Reininger
mesh_terms: D051722:ADAM Proteins / Q000627:therapeutic use*; D000071120:ADAMTS13 Protein; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D015195:Drug Design; D015316:Genetic Therapy / Q000379:methods*; D006467:Hemophilia A / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D001779:Blood Coagulation Factors; D011994:Recombinant Proteins; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
keywords: Haemophilia; gene therapy; long-acting factor VIII; prophylaxis