title: Red algal bromophenols as glucose 6-phosphate dehydrogenase inhibitors.
abstract: Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.
authors.affiliation: Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan. kuri@fish.hokudai.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mikami
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kurihara
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Kim
authors.forename: Koretaro
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D044722:Laurencia / Q000737:chemistry*; D010637:Phenolsulfonphthalein / Q000031:analogs & derivatives* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: C021157:bromophenol red; D005954:Glucosephosphate Dehydrogenase; D010637:Phenolsulfonphthalein