title: Association of COL4A1 genetic polymorphisms with coronary artery disease in Uygur population in Xinjiang, China.
abstract: BACKGROUND
  Type IV collagen is important for the structural integrity and function of basement membranes. Basement membranes surround vascular smooth muscle cells in the media, COL4A1 is the most abundant component of type IV collagen in all Basement membranes. However, the relationship between COL4A1 genetic polymorphisms and coronary artery disease (CAD) remains unclear. We performed a case-control study to explore the association of COL4A1 genetic polymorphisms with CAD in Uygur population of China.
  
  
  METHODS
  1095 Uygur people (727 men, 368 women) including 471 CAD patients and 624 controls were selected for the present study. Two SNPs (rs605143 and rs565470) were genotyped by using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method.
  
  
  RESULTS
  For total and men, the rs605143 was found to be associated with CAD by in a dominate model (p = 0.014, p = 0.013, respectively). The difference remained statistically significant after multivariate adjustment (p = 0.036, p = 0.014, respectively). The rs565470 was also found to be associated with CAD in a recessive model for total and men (both p < 0.001), and the difference remained statistically significant after multivariate adjustment (P = 0.002, P = 0.001, respectively).
  
  
  CONCLUSIONS
  Both rs605143 and rs565470 of COL4A1gene are associated with CAD in Uygur population of China.
authors.forename: Dilare
authors.initials: D
authors.lastname: Adi
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, People's Republic of China. myt_xj@sina.com.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D002681:China; D024141:Collagen Type IV / Q000235:genetics*; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C547475:COL4A1 protein, human; D024141:Collagen Type IV