title: New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; School of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Ming-Yow
authors.initials: MY
authors.lastname: Hung
authors.affiliation: School of Medicine, University of California San Diego, La Jolla, California.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Witztum
authors.affiliation: School of Medicine, University of California San Diego, La Jolla, California. Electronic address: stsimikas@ucsd.edu.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsimikas
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics*; D001021:Aortic Valve / Q000201:enzymology*; D001024:Aortic Valve Stenosis / Q000097:blood*; D000082882:Bicuspid Aortic Valve Disease; D002114:Calcinosis / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006330:Heart Defects, Congenital / Q000235:genetics*; D006349:Heart Valve Diseases / Q000235:genetics*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D011159:Population Surveillance; D012333:RNA, Messenger / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*
chemical_list: D017270:Lipoprotein(a); D012333:RNA, Messenger; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
keywords: Lp-PLA2; aortic stenosis; calcific aortic valve disease; lysophosphatidylcholine; valve interstitial cells