title: Pediatric intracranial arachnoid cysts: comparative effectiveness of surgical treatment options.
abstract: OBJECTIVE
  A variety of surgical approaches for the treatment of pediatric intracranial arachnoid cysts exist. In an effort to identify the optimal surgical treatment for this disorder, we developed a decision analytic model to evaluate outcomes of four surgical approaches in children. These included open craniotomy for cyst excision, open craniotomy for cyst fenestration, endoscopic cyst fenestration, and cystoperitoneal shunting.
  
  
  METHODS
  Pooled data were used to create evidence tables, from which we calculated incidence, relative risks, and summary outcomes in quality-adjusted life years (QALYs) for the four surgical treatments. Our study incorporated data up to 5 years postsurgery.
  
  
  RESULTS
  We analyzed 1,324 cases from 36 case series. There were no significant differences in outcome among the four surgical strategies. The QALYs (maximum of 5) for surgical approaches resulted in a range from 4.79 (for open craniotomy and excision) to 4.92 (for endoscopic fenestration).
  
  
  CONCLUSIONS
  Overall quality of life is comparable between patients undergoing open craniotomy for cyst excision or fenestration, endoscopic fenestration, and cystoperitoneal shunting up to 5 years after surgery. While each approach offers unique advantages and disadvantages, an individualized treatment strategy should be employed in the setting of surgical outcome equipoise.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Silverstein Pavilion, Philadelphia, PA, 19104, USA, zarinasali@gmail.com.
authors.forename: Zarina S
authors.initials: ZS
authors.lastname: Ali
authors.forename: Shih-Shan
authors.initials: SS
authors.lastname: Lang
authors.forename: Dara
authors.initials: D
authors.lastname: Bakar
authors.forename: Phillip B
authors.initials: PB
authors.lastname: Storm
authors.forename: Sherman C
authors.initials: SC
authors.lastname: Stein
mesh_terms: D017677:Age Distribution; D016080:Arachnoid Cysts / Q000601:surgery*; D001927:Brain Diseases / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications / Q000453:epidemiology / Q000628:therapy; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000628:therapy; D019057:Quality-Adjusted Life Years; D012086:Reoperation / Q000706:statistics & numerical data; D017678:Sex Distribution; D016896:Treatment Outcome