title: Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.
abstract: BACKGROUND
  The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria.
  
  
  METHODS
  The association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes.
  
  
  RESULTS
  In the ISOR sample, APOE ε4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than ε3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the ε4 and ε2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele.
  
  
  CONCLUSIONS
  Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the ε4 allele on LDL-cholesterol levels in an Algerian population.
authors.forename: Houssam
authors.initials: H
authors.lastname: Boulenouar
authors.forename: Sounnia
authors.initials: S
authors.lastname: Mediene Benchekor
authors.forename: Djabaria Naïma
authors.initials: DN
authors.lastname: Meroufel
authors.forename: Sarah Aicha
authors.initials: SA
authors.lastname: Lardjam Hetraf
authors.forename: Hadjira
authors.initials: H
authors.lastname: Ouhaibi Djellouli
authors.forename: Xavier
authors.initials: X
authors.lastname: Hermant
authors.forename: Benjamin
authors.initials: B
authors.lastname: Grenier-Boley
authors.forename: Imane
authors.initials: I
authors.lastname: Hamani Medjaoui
authors.forename: Nadhira
authors.initials: N
authors.lastname: Saidi Mehtar
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Leila
authors.initials: L
authors.lastname: Houti
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
authors.affiliation: INSERM, U744; Institut Pasteur de Lille, Université Lille Nord de France, Lille, France. louisa.goumidi@pasteur-lille.fr.
authors.forename: Louisa
authors.initials: L
authors.lastname: Goumidi
mesh_terms: D000328:Adult; D000462:Algeria; D000483:Alleles; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides