title: Quantitative three-dimensional assessment of port-wine stain clearance after laser treatments.
abstract: OBJECTIVE
  Outcomes analysis of laser treatment for port-wine stains has been hampered by the lack of an objective measure of surface area and volume; moreover, treatment success is often gauged by clinician subjective assessment. Three-dimensional (3D) surface imaging has been applied in several medical disciplines to quantify surface changes, with promising results. We hypothesized that 3D surface imaging could be used to objectively measure changes in area and volume of port-wine stains following laser treatment.
  
  
  METHODS
  We performed a retrospective review of consecutive patients with port-wine stains treated over a 20-month time period. Area and volume of the lesions were measured using 3dMD photogrammetric software (3dMD, Atlanta, GA) before and after a series of sequential pulsed dye laser and/or alexandrite laser treatments.
  
  
  RESULTS
  Fifty-five patients with 59 port-wine stains were included in the study. The initial average measured area was 44.3 cm(2) ; final average measured area decreased to 36.9 cm(2) (P < 0.001). The average volume change was 1.20 cc for all PWS included in the study and 1.90 cc for lesions that received at least 5 laser treatments within the study period.
  
  
  CONCLUSIONS
  Three-dimensional photography demonstrated area and volume changes in patients with port-wine stains after laser treatments. Future studies to determine if statistically significant changes correlate with clinically appreciable changes are warranted.
authors.affiliation: Carolyn and Peter Lynch Center for Laser and Reconstructive Surgery, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Alice
authors.initials: A
authors.lastname: Frigerio
authors.forename: Prabhat K
authors.initials: PK
authors.lastname: Bhama
authors.forename: Oon T
authors.initials: OT
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D054025:Lasers, Dye / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010781:Photography; D019339:Port-Wine Stain / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: 3dMD; laser photocoagulation; port-wine stain