title: The hows and whys of constructing a native recombinant cholera vaccine.
abstract: Emergence of different ctxB genotypes within virulent Vibrio cholerae populations accentuates the need to develop a vaccine that has the potential to protect against all cholera toxin genotypes. Oral administration of rCTB-alone and in combination with 2 dominant domestic killed whole cells of V. cholerae (O1 Ogawa El Tor and O1 Inaba El Tor) plus one standard V. cholerae (O1 Ogawa classic ATCC 14035)-has shown satisfactory protection as a potent vaccine candidate against toxigenic V. cholerae.
authors.affiliation: Department of Bacteriology; Faculty of Medical Sciences; Tarbiat Modares University; Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Boustanshenas
authors.affiliation: Department of Bacteriology; Faculty of Medical Sciences; Tarbiat Modares University; Tehran, Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Bakhshi
mesh_terms: D000818:Animals; D002772:Cholera Toxin / Q000276:immunology*; D022121:Cholera Vaccines / Q000276:immunology*; D005260:Female
chemical_list: D022121:Cholera Vaccines; D002772:Cholera Toxin
keywords: Vibrio cholerae; cholera toxin; native vaccine; rabbit; recombinant CTB