title: Estimation of the lateral ventricles volumes from a 2D image and its relationship with cerebrospinal fluid flow.
abstract: OBJECTIVE
  This work suggests a fast estimation method of the lateral ventricles volume from a 2D image and then determines if this volume is correlated with the cerebrospinal fluid flow at the aqueductal and cerebral levels in neurodegenerative diseases.
  
  
  METHODS
  Forty-five elderly patients suffering from Alzheimer's disease (19), normal pressure hydrocephalus (13), and vascular dementia (13) were involved and underwent anatomical and phase contrast MRI scans. Lateral ventricles and stroke volumes were assessed on anatomical and phase contrast scans, respectively. A common reference plane was used to calculate the lateral ventricles' area on 2D images.
  
  
  RESULTS
  The largest volumes were observed in hydrocephalus patients. The linear regression between volumes and areas was computed, and a strong positive correlation was detected (R² = 0.9). A derived equation was determined to represent the volumes for any given area. On the other hand, no significant correlations were detected between ventricles and stroke volumes (R² ≤ 0.15).
  
  
  CONCLUSIONS
  Lateral ventricles volumes are significantly proportional to the 2D reference section area and could be used for patients' follow-up even if 3D images are unavailable. The cerebrospinal fluid fluctuations in brain disorders may depend on many physiological parameters other than the ventricular morphology.
authors.forename: Bader
authors.initials: B
authors.lastname: Chaarani
authors.affiliation: Department of Imaging, Jules Verne University of Picardy and Amiens University Hospital, 80054 Amiens Cedex, France.
authors.forename: Chaarani
authors.initials: C
authors.lastname: Bader
authors.forename: Cyrille
authors.initials: C
authors.lastname: Capel
authors.forename: Capel
authors.initials: C
authors.lastname: Cyrille
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Zmudka
authors.forename: Zmudka
authors.initials: Z
authors.lastname: Jadwiga
authors.forename: Joel
authors.initials: J
authors.lastname: Daouk
authors.forename: Daouk
authors.initials: D
authors.lastname: Joel
authors.forename: Anthony
authors.initials: A
authors.lastname: Fichten
authors.forename: Catherine
authors.initials: C
authors.lastname: Gondry-Jouet
authors.forename: Gondry-Jouet
authors.initials: GJ
authors.lastname: Catherine
authors.forename: Roger
authors.initials: R
authors.lastname: Bouzerar
authors.forename: Bouzerar
authors.initials: B
authors.lastname: Roger
authors.forename: Olivier
authors.initials: O
authors.lastname: Balédent
authors.forename: Balédent
authors.initials: B
authors.lastname: Olivier
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000473:pathology; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000473:pathology; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography