title: DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications.
abstract: Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed.
authors.affiliation: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703HB, Wageningen, The Netherlands, pierpaolo.falcicchio@wur.nl.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Falcicchio
authors.forename: Suzanne
authors.initials: S
authors.lastname: Wolterink-Van Loo
authors.forename: Maurice C R
authors.initials: MC
authors.lastname: Franssen
authors.forename: John
authors.initials: J
authors.lastname: van der Oost
mesh_terms: D000446:Aldehyde-Lyases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D019843:Archaeal Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D004099:Dihydroxyacetone Phosphate / Q000737:chemistry / Q000378:metabolism; D004795:Enzyme Stability; D006358:Hot Temperature
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D004099:Dihydroxyacetone Phosphate; D000446:Aldehyde-Lyases