title: High resolution myocardial first-pass perfusion imaging with extended anatomic coverage.
abstract: OBJECTIVE
  To evaluate and to compare Parallel Imaging and Compressed Sensing acquisition and reconstruction frameworks based on simultaneous multislice excitation for high resolution contrast-enhanced myocardial first-pass perfusion imaging with extended anatomic coverage.
  
  
  METHODS
  The simultaneous multislice imaging technique MS-CAIPIRINHA facilitates imaging with significantly extended anatomic coverage. For additional resolution improvement, equidistant or random undersampling schemes, associated with corresponding reconstruction frameworks, namely Parallel Imaging and Compressed Sensing can be used. By means of simulations and in vivo measurements, the two approaches were compared in terms of reconstruction accuracy. Comprehensive quality metrics were used, identifying statistical and systematic reconstruction errors.
  
  
  RESULTS
  The quality measures applied allow for an objective comparison of the frameworks. Both approaches provide good reconstruction accuracy. While low to moderate noise enhancement is observed for the Parallel Imaging approach, the Compressed Sensing framework is subject to systematic errors and reconstruction induced spatiotemporal blurring.
  
  
  CONCLUSIONS
  Both techniques allow for perfusion measurements with a resolution of 2.0 × 2.0 mm(2) and coverage of six slices every heartbeat. Being not affected by systematic deviations, the Parallel Imaging approach is considered to be superior for clinical studies.
authors.affiliation: Institute of Radiology, University of Würzburg, Würzburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Stäb
authors.forename: Tobias
authors.initials: T
authors.lastname: Wech
authors.forename: Felix A
authors.initials: FA
authors.lastname: Breuer
authors.forename: Andreas Max
authors.initials: AM
authors.lastname: Weng
authors.forename: Christian Oliver
authors.initials: CO
authors.lastname: Ritter
authors.forename: Dietbert
authors.initials: D
authors.lastname: Hahn
authors.forename: Herbert
authors.initials: H
authors.lastname: Köstler
mesh_terms: D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage; D003324:Coronary Artery Disease / Q000175:diagnosis*; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds / Q000008:administration & dosage; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
keywords: CAIPIRINHA; cardiac imaging; compressed sensing; multislice; myocardial perfusion; parallel imaging