title: Role of Angptl4 in vascular permeability and inflammation.
abstract: BACKGROUND
  Angptl4 is a secreted protein involved in the regulation of vascular permeability, angiogenesis, and inflammatory responses in different kinds of tissues. Increases of vascular permeability and abnormality changes in angiogenesis contribute to the pathogenesis of tumor metastasis, ischemic-reperfusion injury. Inflammatory response associated with Angptl4 also leads to minimal change glomerulonephritis, wound healing. However, the role of Angptl4 in vascular permeability, angiogenesis, and inflammation is controversy. Hence, an underlying mechanism of Angptl4 in different kind of tissues needs to be further clarified.
  
  
  METHODS
  Keywords such as angptl4, vascular permeability, angiogenesis, inflammation, and endothelial cells were used in search tool of PUBMED, and then the literatures associated with Angptl4 were founded and read.
  
  
  RESULTS
  Data have established Angptl4 as the key modulator of both vascular permeability and angiogenesis; furthermore, it may also be related to the progression of metastatic tumors, cardiovascular events, and inflammatory diseases. This view focuses on the recent advances in our understanding of the role of Angptl4 in vascular permeability, angiogenesis, inflammatory signaling and the link between Angptl4 and multiple diseases such as cancer, cardiovascular diseases, diabetic retinopathy, and kidney diseases.
  
  
  CONCLUSIONS
  Taken together, Angptl4 modulates vascular permeability, angiogenesis, inflammatory signaling, and associated diseases. The use of Angptl4-modulating agents such as certain drugs, food constituents (such as fatty acids), nuclear factor (such as PPARα), and bacteria may treat associated diseases such as tumor metastasis, ischemic-reperfusion injury, inflammation, and chronic low-grade inflammation. However, the diverse physiological functions of Angptl4 in different tissues can lead to potentially deleterious side effects when used as a therapeutic target. In this regard, a better understanding of the underlying mechanisms for Angptl4 in different tissues is necessary.
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, 40037, China, Guoliang0925@aliyun.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Li
authors.forename: Fu-Yun
authors.initials: FY
authors.lastname: Ji
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhong
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Lv
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Wu
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Qian
mesh_terms: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000378:metabolism*; D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins