title: Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars.
abstract: We report the sequencing at 131× coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig.
authors.affiliation: 1] Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, China. [2] Biodynamic Optical Imaging Center (BIOPIC), Peking-Tsinghua Center for Life Sciences and School of Life Sciences, Peking University, Beijing, China. [3].
authors.forename: Mingzhou
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authors.lastname: Li
authors.forename: Shilin
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authors.lastname: Tian
authors.forename: Long
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authors.lastname: Jin
authors.forename: Guangyu
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authors.lastname: Zhou
authors.forename: Ying
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authors.lastname: Li
authors.forename: Yuan
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authors.lastname: Zhang
authors.forename: Tao
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authors.lastname: Wang
authors.forename: Carol K L
authors.initials: CK
authors.lastname: Yeung
authors.forename: Lei
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authors.lastname: Chen
authors.forename: Jideng
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authors.lastname: Ma
authors.forename: Jinbo
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authors.lastname: Zhang
authors.forename: Anan
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authors.lastname: Jiang
authors.forename: Ji
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authors.lastname: Li
authors.forename: Chaowei
authors.initials: C
authors.lastname: Zhou
authors.forename: Jie
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authors.lastname: Zhang
authors.forename: Yingkai
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authors.lastname: Liu
authors.forename: Xiaoqing
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authors.lastname: Sun
authors.forename: Hongwei
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authors.lastname: Zhao
authors.forename: Zexiong
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authors.lastname: Niu
authors.forename: Pinger
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authors.lastname: Lou
authors.forename: Lingjin
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authors.lastname: Xian
authors.forename: Xiaoyong
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authors.lastname: Shen
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Liu
authors.forename: Shunhua
authors.initials: S
authors.lastname: Zhang
authors.forename: Mingwang
authors.initials: M
authors.lastname: Zhang
authors.forename: Li
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authors.lastname: Zhu
authors.forename: Surong
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authors.lastname: Shuai
authors.forename: Lin
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authors.lastname: Bai
authors.forename: Guoqing
authors.initials: G
authors.lastname: Tang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Liu
authors.forename: Yanzhi
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authors.lastname: Jiang
authors.forename: Miaomiao
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authors.lastname: Mai
authors.forename: Jian
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authors.lastname: Xiao
authors.forename: Xun
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authors.lastname: Wang
authors.forename: Qi
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authors.lastname: Zhou
authors.forename: Zhiquan
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authors.lastname: Wang
authors.forename: Paul
authors.initials: P
authors.lastname: Stothard
authors.forename: Ming
authors.initials: M
authors.lastname: Xue
authors.forename: Xiaolian
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authors.lastname: Gao
authors.forename: Zonggang
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authors.lastname: Luo
authors.forename: Yiren
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authors.lastname: Gu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhu
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Hu
authors.forename: Yaofeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Graham S
authors.initials: GS
authors.lastname: Plastow
authors.forename: Jinyong
authors.initials: J
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Jiang
authors.forename: Kui
authors.initials: K
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Xuewei
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authors.lastname: Li
authors.forename: Ruiqiang
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authors.lastname: Li
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics; D000531:Altitude; D000818:Animals; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation / Q000502:physiology; D016678:Genome / Q000235:genetics; D005810:Multigene Family; D010802:Phylogeny; D012472:Salivation / Q000235:genetics; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D034421:Sus scrofa / Q000235:genetics*; D018609:Tibet