title: Barrier-repair prescription moisturizers: do we really need them? Facts and controversies.
abstract: There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.
authors.affiliation: The Dermatology Unit, Kaplan Medical Center, Rechovot, Israel. Affiliated to The School of Medicine, Hebrew University and Hadassah Medical Center, Jerusalem, Israel. Electronic address: wolf_r@netvision.net.il.
authors.forename: Ronni
authors.initials: R
authors.lastname: Wolf
authors.forename: Lawrence Charles
authors.initials: LC
authors.lastname: Parish
mesh_terms: D000577:Amides; D002518:Ceramides / Q000627:therapeutic use; D002592:Cetomacrogol / Q000627:therapeutic use; D002784:Cholesterol / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology*; D004338:Drug Combinations; D004643:Emollients / Q000627:therapeutic use*; D063388:Endocannabinoids / Q000627:therapeutic use; D004983:Ethanolamines / Q000627:therapeutic use; D005227:Fatty Acids / Q000627:therapeutic use; D005233:Fatty Alcohols / Q000627:therapeutic use; D006801:Humans; D008899:Mineral Oil / Q000627:therapeutic use; D004366:Nonprescription Drugs / Q000627:therapeutic use; D010169:Palmitic Acids / Q000627:therapeutic use; D010577:Petrolatum / Q000627:therapeutic use; D055553:Prescription Drugs / Q000627:therapeutic use; D063465:Skin Cream / Q000627:therapeutic use*; D014870:Water Loss, Insensible
chemical_list: D000577:Amides; D002518:Ceramides; D004338:Drug Combinations; D004643:Emollients; D063388:Endocannabinoids; C539259:EpiCeram; D004983:Ethanolamines; D005227:Fatty Acids; D005233:Fatty Alcohols; D004366:Nonprescription Drugs; D010169:Palmitic Acids; D055553:Prescription Drugs; C567979:cetomacrogol, cetostearyl alcohol, mineral oil, petrolatum drug combination; C005958:palmidrol; D010577:Petrolatum; D008899:Mineral Oil; D002592:Cetomacrogol; D002784:Cholesterol