title: Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.
abstract: In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10(-9), OR=1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Frampton
authors.forename: Miguel Inacio
authors.initials: MI
authors.lastname: da Silva Filho
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Hauke
authors.initials: H
authors.lastname: Thomsen
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
authors.forename: Jayaram
authors.initials: J
authors.lastname: Vijayakrishnan
authors.forename: Rosie
authors.initials: R
authors.lastname: Cooke
authors.forename: Victor
authors.initials: V
authors.lastname: Enciso-Mora
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Amy
authors.initials: A
authors.lastname: Lloyd
authors.forename: Amy
authors.initials: A
authors.lastname: Holroyd
authors.forename: Lewin
authors.initials: L
authors.lastname: Eisele
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Jöckel
authors.forename: Sabine
authors.initials: S
authors.lastname: Ponader
authors.forename: Elke Pogge
authors.initials: EP
authors.lastname: von Strandmann
authors.forename: Tracy
authors.initials: T
authors.lastname: Lightfoot
authors.forename: Eve
authors.initials: E
authors.lastname: Roman
authors.forename: Annette
authors.initials: A
authors.lastname: Lake
authors.forename: Dorothy
authors.initials: D
authors.lastname: Montgomery
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Jarrett
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Swerdlow
authors.forename: Andreas
authors.initials: A
authors.lastname: Engert
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D015870:Gene Expression; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006689:Hodgkin Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D020825:T-Box Domain Proteins / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D044465:White People
chemical_list: C491199:EOMES protein, human; D020825:T-Box Domain Proteins; D016159:Tumor Suppressor Protein p53