title: Impact of unlabeled French antibiotic guidelines on antibiotic prescriptions for acute respiratory tract infections in 7 Pediatric Emergency Departments, 2009-2012.
abstract: From November 2009 to October 2012, implementation of guidelines, unlabeled by the French Agency of Health Products, changed the categories of antibiotics prescribed for acute respiratory tract infections in 7 pediatric emergency departments. During the study, 36,413 acute respiratory tract infections-related antibiotic prescriptions were prescribed. Amoxicillin prescriptions rose from 30.0% to 84.7%, while amoxicillin-clavulanate and cefpodoxime prescriptions decreased to 10.2% and 2.5%, respectively.
authors.affiliation: From the *Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris; †Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development Team, Villejuif; ‡Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Antoine Béclère and Université Paris 11, Clamart; §Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Ambroise Paré and Université Versailles-Saint-Quentin-en-Yvelines, Boulogne; ¶Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Bicêtre and Université Paris 11, Kremlin-Bicêtre; ‖Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Jean Verdier and Université Paris 13, Bondy; ††Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Louis Mourier and Université Paris 7 Denis Diderot, Colombes; ‡‡Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Armand Trousseau and Université Paris 6 Descartes, Paris; §§Pediatric Department, Centre Hospitalier Intercommunal, Créteil; and ¶¶Hôpitaux de Paris (APHP), Clinical Epidemiologic Unit and INSERM CIE-5, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Angoulvant
authors.forename: Miguel
authors.initials: M
authors.lastname: Pereira
authors.forename: Francis
authors.initials: F
authors.lastname: Perreaux
authors.forename: Valerie
authors.initials: V
authors.lastname: Soussan
authors.forename: Luu-Ly
authors.initials: LL
authors.lastname: Pham
authors.forename: Thanh-Van
authors.initials: TV
authors.lastname: Trieu
authors.forename: Bogdan
authors.initials: B
authors.lastname: Cojocaru
authors.forename: Romain
authors.initials: R
authors.lastname: Guedj
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
authors.forename: Corinne
authors.initials: C
authors.lastname: Alberti
authors.forename: Vincent
authors.initials: V
authors.lastname: Gajdos
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D002675:Child, Preschool; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D024881:Drug Resistance, Bacterial; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005602:France; D006801:Humans; D007223:Infant; D010372:Pediatrics; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000453:epidemiology; D000097623:Cefpodoxime
chemical_list: D000658:Amoxicillin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents; D015296:Ceftizoxime; D000097623:Cefpodoxime