title: Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle.
abstract: The Negishi coupling reaction between arylzinc halide reagents and (11)CH3I has been used to synthesise (11)C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [(11)C]MPEP has been radiolabelled using this technique.
authors.affiliation: Institute of Psychiatry, King's College London, De Crespigny Road, Denmark Hill, London SE5 8AF, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kealey
authors.forename: J
authors.initials: J
authors.lastname: Passchier
authors.forename: M
authors.initials: M
authors.lastname: Huiban
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry*; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D010165:Palladium / Q000737:chemistry*; D049268:Positron-Emission Tomography; D064529:Receptor, Metabotropic Glutamate 5 / Q000737:chemistry
chemical_list: D002250:Carbon Radioisotopes; D006841:Hydrocarbons, Aromatic; D064529:Receptor, Metabotropic Glutamate 5; D010165:Palladium