title: A new antibacterial amino phenyl pyrrolidone derivative from a novel marine gliding bacterium Rapidithrix thailandica.
abstract: A recently described marine gliding bacterium Rapidithrix thailandica strain TISTR 1741 was isolated from biofilm specimen collected from the Andaman Sea in Thailand. Four liters fermentation broth of R. thailandica TISTR 1741 cultivated in VY/2 medium were extracted with methanol to yield a novel amino phenyl pyrrolidone derivative compound (1) with antibacterial activities. The chemical structure and physico-chemical properties of 1 were investigated by spectrometry techniques. Compound 1 exhibited selective inhibition against vancomycin-resistant Enterococcus faecalis (VRE) with the MIC of 5.97 mM.
authors.affiliation: Department of Aquatic Science, Faculty of Natural Resources, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand, yutthapong.s@psu.ac.th.
authors.forename: Yutthapong
authors.initials: Y
authors.lastname: Sangnoi
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
authors.forename: Vullapa
authors.initials: V
authors.lastname: Arunpairojana
authors.forename: Akkharawit
authors.initials: A
authors.lastname: Kanjana-Opas
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D041963:Bacteroidetes / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification; D013293:Enterococcus faecalis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012623:Seawater / Q000382:microbiology; D013057:Spectrum Analysis; D013785:Thailand
chemical_list: D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones