title: Drug-induced hyperthermic syndromes: part I. Hyperthermia in overdose.
abstract: Drugs and natural compounds that affect the thermoregulatory system can induce or contribute to hyperthermia when used in excess. Hyperthermia associated with drug overdose is dangerous and potentially lethal. This article reviews the body's process of maintaining thermodynamic equilibrium, and describes the mechanisms by which it is influenced by sympathomimetic and anticholinergic drugs, salicylates, and thyroid replacement medications. Appropriate treatment strategies such as cooling and the administration of counteractive medications are discussed.
authors.affiliation: Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, Sixth Floor, Suite 200, Baltimore, MD 21201, USA; Department of Pharmacy, University of Maryland Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA. Electronic address: bhayes@umem.org.
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Hayes
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Martinez
authors.forename: Fermin
authors.initials: F
authors.lastname: Barrueto
mesh_terms: D018680:Cholinergic Antagonists / Q000009:adverse effects; D062787:Drug Overdose / Q000150:complications*; D005334:Fever / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D012640:Seizures / Q000150:complications; D013566:Sympathomimetics / Q000009:adverse effects; D015262:Xenobiotics / Q000009:adverse effects
chemical_list: D018680:Cholinergic Antagonists; D013566:Sympathomimetics; D015262:Xenobiotics
keywords: Anticholinergics; Cocaine; Hypermetabolism; Hyperthermia; Methlenedioxymethamphetamine; Salicylates; Sympathomimetics; Thermoregulatory system