title: [Predictive methods versus clinical titration for the initiation of lithium therapy. A systematic review].
abstract: BACKGROUND
  When lithium is administered, the clinician needs to know when the lithium in the patient&rsquo;s blood has reached a therapeutic level. At the initiation of treatment the level is usually achieved gradually through the application of the titration method. In order to increase the efficacy of this procedure several methods for dosing lithium and for predicting lithium levels have been developed.
  
  
  OBJECTIVE
  To conduct a systematic review of the publications relating to the various methods for dosing lithium or predicting lithium levels at the initiation of therapy.
  
  
  METHODS
  We searched Medline systematically for articles published in English, French or Dutch between 1966 and April 2012 which described or studied a method for dosing lithium or for predicting the lithium level reached following a specific dosage. We screened the reference lists of relevant articles in order to locate additional papers.
  
  
  RESULTS
  We found 38 lithium prediction methods, in addition to the clinical titration method. These methods can be divided into two categories: the &lsquo;a priori&rsquo; methods and the &lsquo;test-dose&rsquo; methods, the latter requiring the administration of a test dose of lithium.
  
  
  CONCLUSIONS
  The lithium prediction methods generally achieve a therapeutic blood level faster than the clinical titration method, but none of the methods achieves convincing results. On the basis of our review, we propose that the titration method should be used as the standard method in clinical practice.
authors.forename: I
authors.initials: I
authors.lastname: Geeraerts
authors.forename: P
authors.initials: P
authors.lastname: Sienaert
mesh_terms: D018692:Antimanic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D018692:Antimanic Agents; D008094:Lithium