title: Systems biology of the vervet monkey.
abstract: Nonhuman primates (NHP) provide crucial biomedical model systems intermediate between rodents and humans. The vervet monkey (also called the African green monkey) is a widely used NHP model that has unique value for genetic and genomic investigations of traits relevant to human diseases. This article describes the phylogeny and population history of the vervet monkey and summarizes the use of both captive and wild vervet monkeys in biomedical research. It also discusses the effort of an international collaboration to develop the vervet monkey as the most comprehensively phenotypically and genomically characterized NHP, a process that will enable the scientific community to employ this model for systems biology investigations.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Jasinska
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Schmitt
authors.forename: Susan K
authors.initials: SK
authors.lastname: Service
authors.forename: Rita M
authors.initials: RM
authors.lastname: Cantor
authors.forename: Ken
authors.initials: K
authors.lastname: Dewar
authors.forename: James D
authors.initials: JD
authors.lastname: Jentsch
authors.forename: Jay R
authors.initials: JR
authors.lastname: Kaplan
authors.forename: Trudy R
authors.initials: TR
authors.lastname: Turner
authors.forename: Wesley C
authors.initials: WC
authors.lastname: Warren
authors.forename: George M
authors.initials: GM
authors.lastname: Weinstock
authors.forename: Roger P
authors.initials: RP
authors.lastname: Woods
authors.forename: Nelson B
authors.initials: NB
authors.lastname: Freimer
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D010802:Phylogeny; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics*; D015302:Simian Immunodeficiency Virus / Q000235:genetics*; D049490:Systems Biology / Q000379:methods*
keywords: African green monkey; genetics; genomics; phenomics; simian immunodeficiency virus [SIV]; systems biology; transcriptomics; vervet