title: γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation.
abstract: We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu.
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Li
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.forename: Youhong
authors.initials: Y
authors.lastname: Niu
authors.forename: Qiao
authors.initials: Q
authors.lastname: Qiao
authors.forename: Jeremiah D
authors.initials: JD
authors.lastname: Tipton
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D018716:Molecular Mimicry; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D019151:Peptide Library; D055503:Protein Multimerization / Q000187:drug effects*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D019151:Peptide Library