title: Hepatic metastasis with heterologous rhabdomyoblastic differentiation in a patient with gastrointestinal stromal tumor treated with imatinib.
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the intestinal tract. In patients with locally advanced and/or metastatic GIST, the introduction of tyrosine kinase inhibitor, imatinib mesylate, has transformed the management of this previously untreatable neoplasm into a treatable entity. Approximately 80% of advanced metastatic GISTs respond to imatinib treatment. However, the majority of patients suffer disease progression at a median of 2 years due to drug resistance. Generally progressing GISTs retain their typical morphology. Herein, we report an extremely rare case of progressive metastatic GIST with heterologous rhabdomyoblastic differentiation after, imatinib mesylate treatment. We also review the relevant literature.
authors.affiliation: Department of Pathology, Global Hospital and Health City, Chennai, Tamil Nadu, India.
authors.forename: Mukul
authors.initials: M
authors.lastname: Vij
authors.forename: Susama
authors.initials: S
authors.lastname: Patra
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rela
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D003893:Desmin / Q000032:analysis; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D006651:Histocytochemistry; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D018008:Myogenin / Q000032:analysis; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000473:pathology; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D001549:Benzamides; D003893:Desmin; D018008:Myogenin; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate