title: Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children.
abstract: The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell-dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics I, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
authors.forename: Markus
authors.initials: M
authors.lastname: Reindl
mesh_terms: D001323:Autoantibodies / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D002648:Child; D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology* / Q000378:metabolism*; D006801:Humans
chemical_list: D001323:Autoantibodies