title: [Vigilance for veterinary medicinal products: reports of adverse reactions in the year 2012].
abstract: 197 adverse reactions of Swissmedic-authorized veterinary medicinal products were reported during the year 2012 (2011: 167). Species and drug classes remain unchanged over the years: most of the reports related to reactions following the use of antiparasitic products (37.6 %), antiinfectives (15.7 %) or non-steroidal antiinflammatory drugs (11.7 %) in companion animals (94 dogs and 53 cats) followed by cattle/calves (29). Additionally, 45 cases transmitted by the Swiss Toxicological Information Centre in Zürich were processed. We discuss a paradoxical reaction under the potential influence of acepromazine as well as a modified protocol for treating permethrin intoxication in cats. Finally, the vaccinovigilance program received 95 declarations following the application of various vaccines, mainly to dogs or cats.
authors.affiliation: Institut für Veterinärpharmakologie und -toxikologie der Universität Zürich und Swissmedic, Schweizerisches Heilmittelinstitut, Bern.
authors.forename: C R
authors.initials: CR
authors.lastname: Müntener
authors.forename: L
authors.initials: L
authors.lastname: Bruckner
authors.forename: J
authors.initials: J
authors.lastname: Kupper
authors.forename: F R
authors.initials: FR
authors.lastname: Althaus
authors.forename: M
authors.initials: M
authors.lastname: Schäublin
mesh_terms: D000075:Acepromazine / Q000009:adverse effects; D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards / Q000706:statistics & numerical data*; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000977:Antiparasitic Agents / Q000009:adverse effects; D002371:Cat Diseases / Q000139:chemically induced / Q000628:therapy; D002415:Cats; D002417:Cattle; D004285:Dogs; D018492:Dopamine Antagonists / Q000009:adverse effects; D007306:Insecticides / Q000506:poisoning; D026023:Permethrin / Q000506:poisoning; D011041:Poisoning / Q000628:therapy / Q000662:veterinary; D013557:Switzerland; D014612:Vaccines / Q000009:adverse effects; D019155:Veterinary Drugs / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000977:Antiparasitic Agents; D018492:Dopamine Antagonists; D007306:Insecticides; D014612:Vaccines; D019155:Veterinary Drugs; D026023:Permethrin; D000075:Acepromazine
keywords: Acepromazin; Aggression; Permethrinvergiftung; Pharmacovigilance; Vaccinovigilance; acepromazine; aggression; permethrin intoxication; pharmacovigilance; vaccinovigilance