title: Two new compounds from Crataegus pinnatifida and their antithrombotic activities.
abstract: One new sesquiterpene, (1α,4aβ,8aα)-1-isopropanol-4a-methyl-8-methylenedecahydronaphthalene (1), with one new phenylpropanoid, threo-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (2), along with four known phenylpropanoids were isolated from Crataegus pinnatifida. The structures of compounds 1 and 2 were elucidated on the basis of 1D, 2D NMR analyses, and HR-ESI-MS. The antithrombotic activity in vitro of all isolates was assayed, and only compound 1 exhibited potent antithrombotic activity by inhibiting platelet aggregation in rat plasma by 81.4% at 1 mg/ml.
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Zhou
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Huang
authors.forename: Pin-Yi
authors.initials: PY
authors.lastname: Gao
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Li
authors.forename: Dian-Ming
authors.initials: DM
authors.lastname: Li
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Li
authors.forename: Shao-Jiang
authors.initials: SJ
authors.lastname: Song
mesh_terms: D000818:Animals; D027825:Crataegus / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D012717:Sesquiterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C587146:(1alpha,4abeta,8aalpha)-1-isopropanol-4a-methyl-8-methylenedecahydronaphthalene; D005343:Fibrinolytic Agents; D010666:Phenylpropionates; D012717:Sesquiterpenes; C587145:threo-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol