title: Frequency of ERG-positive prostate carcinoma in Polands.
abstract: Prostatic carcinoma (PC) is one of the most frequent cancers in men. Molecular pathogenesis of PC remains poorly understood. Translocations involving ERG were found to be the single most frequent genetic event. A strong correlation exists between this translocation and ERG positivity on immunohistochemistry. The rate of ERG positivity and its relationship with other clinicopathological parameters differ between populations and between studies; in particular, there are few data on ERG-positive PC in Eastern Europeans. In the present study, tissue microarrays of unselected PC cases were constructed and standard immunohistochemistry for ERG performed. The results were compared with the basic pathologic prognostic parameters. The group under study consisted of 113 cases; 52 (46.02%) were positive for ERG. The positive cases showed a slightly higher Gleason score (median 6 vs. 7). The majority of ERG-positive cases showed nerve bundle invasion and were also less likely to be prostate confined than negative ones. In conclusion, the frequency of ERG-positive PC in our series is similar to Western populations, and they show some unfavorable prognostic features.
authors.affiliation: Krzysztof Okoń MD, PhD, Katedra Patomorfologii CMUJ, ul. Grzegórzecka 16, 31-531 Kraków, e-mail: k.okon@uj.edu.pl.
authors.forename: Karolina
authors.initials: K
authors.lastname: Kaczmarczyk
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Dyduch
authors.forename: Magdalena
authors.initials: M
authors.lastname: Białas
authors.forename: Sergiusz
authors.initials: S
authors.lastname: Demczuk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szopiński
authors.forename: Piotr
authors.initials: P
authors.lastname: Chłosta
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Okoń
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011044:Poland; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D046888:Tissue Array Analysis; D015534:Trans-Activators / Q000235:genetics*; D000071230:Transcriptional Regulator ERG; D014178:Translocation, Genetic
chemical_list: C072312:ERG protein, human; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG