title: Ability of FDG-PET/CT in the detection of gallbladder cancer.
abstract: OBJECTIVE
  To assess the value of FDG-PET/CT in the evaluation of gallbladder carcinomas (GBC).
  
  
  METHODS
  A prospective cohort of patients with suspicion of or confirmed GBC was studied with FDG-PET/CT. Diagnostic accuracy parameters were calculated in comparison with pathology and/or the clinical course of patients. Clinical impact of PET/CT imaging was estimated.
  
  
  RESULTS
  Forty-nine patients were enrolled (34 malignant tumors, 15 benign lesions; 37 staging, 12 restaging). Overall diagnostic accuracy was 95.9% for the diagnosis of the primary lesion, 85.7% for lymph node involvement and 95.9% for metastatic disease. Mean SUVmax in malignant gallbladder lesions was 7.92 ± 6.25 Analysis of ROC curves showed a SUVmax cut-off value of 3.62 for malignancy (S: 78.1%; Sp: 88.2%). Diagnostic accuracy in the restaging group reached 100%. FDG-PET/CT changed the management of 22.4% of the population.
  
  
  CONCLUSIONS
  Diagnosis of malignancy or benignity of suspicious gallbladder lesions is accurately made with FDG PET/CT, allowing a precise staging of GBC due to its ability to identify unsuspected metastatic disease. SUVmax has a complementary role in addition to visual analysis.
authors.affiliation: Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Huelva, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ramos-Font
authors.forename: Manuel
authors.initials: M
authors.lastname: Gómez-Rio
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Fernández
authors.forename: Amelia
authors.initials: A
authors.lastname: Jiménez-Heffernan
authors.forename: Rocío
authors.initials: R
authors.lastname: Sánchez Sánchez
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Llamas-Elvira
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000175:diagnosis; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: diagnostic accuracy; fluorodeoxiglucose F18; gallbladder neoplasm; neoplasm staging; positron-emission tomography and computed tomography