title: Association of the C242T polymorphism in the NAD(P)H oxidase P22 phox gene with type 2 diabetes mellitus risk: a meta-analysis.
abstract: OBJECTIVE
  A number of epidemiological studies have explored the association between NAD(P)H oxidase P22 phox gene C242T (rs4673) polymorphism and susceptibility to type 2 diabetes mellitus (T2DM), but the results are still debatable. Therefore, we conducted a meta-analysis to assess the potential association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk.
  
  
  METHODS
  Electronic literature searches of the PubMed, Embase, Web of Science, CBMdisc, CNKI and Google Scholar were performed up to June 15, 2013. Additionally, hand searching of the references of identified articles was performed. Data analyses were carried out by Stata 11.0.
  
  
  RESULTS
  Seven studies were included in the final meta-analysis, covering a total of 1661 T2DM cases and 1265 controls. The results showed evidence for significant association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk (for T/T vs. T/C: OR=1.61, 95% CI=1.14-2.26, p=0.007; for T/T vs. T/C+C/C: OR=1.50, 95% CI=1.10-2.05, p=0.009). In the subgroup analysis, there was also evidence for significant association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk, either for Asians (T/T vs. T/C+C/C: OR=1.74, 95% CI=1.15-2.64, p=0.009) or for non-Asians (for T allele vs C allele: OR=1.30, 95% CI=1.04-1.61, p=0.02).
  
  
  CONCLUSIONS
  The present meta-analysis indicates that the NAD(P)H oxidase P22 phox gene 242 T allele might be associated with an increased T2DM risk.
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Institute for Surgery Research, Third Military Medical University, Chongqing Institute of Hypertension , Chongqing , China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Sun
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Yin
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
authors.forename: Zhencheng
authors.initials: Z
authors.lastname: Yan
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human