title: Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.
abstract: Certain amphipathic α-helical peptides can functionally mimic many of the properties of full-length apolipoproteins, thereby offering an approach to modulate high-density lipoprotein (HDL) for combating atherosclerosis. In this Perspective, we summarize the key findings and advances over the past 25 years in the development of peptides that mimic apolipoproteins, especially apolipoprotein A-I (apoA-I). This assemblage of information provides a reasonably clear picture of the state of the art in the apolipoprotein mimetic field, an appreciation of the potential for such agents in pharmacotherapy, and a sense of the opportunities for optimizing the functional properties of HDL.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Luke J
authors.initials: LJ
authors.lastname: Leman
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Maryanoff
authors.forename: M Reza
authors.initials: MR
authors.lastname: Ghadiri
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016632:Apolipoprotein A-I / Q000737:chemistry*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000517:prevention & control; D032701:Biomimetics; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D000924:Anticholesteremic Agents; D016632:Apolipoprotein A-I; D002316:Cardiotonic Agents; D008076:Cholesterol, HDL; D010446:Peptide Fragments