title: Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34⁺ cells.
abstract: HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34⁺ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34⁺ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.
authors.affiliation: *Laboratory of Cellular Immunology, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy; †Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy; ‡Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; and §Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Bordoni
authors.forename: Michele
authors.initials: M
authors.lastname: Bibas
authors.forename: Domenico
authors.initials: D
authors.lastname: Viola
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sacchi
authors.forename: Chiara
authors.initials: C
authors.lastname: Agrati
authors.forename: Germana
authors.initials: G
authors.lastname: Castelli
authors.forename: Adriana
authors.initials: A
authors.lastname: Ammassari
authors.forename: Alessandra
authors.initials: A
authors.lastname: Amendola
authors.forename: Isabella
authors.initials: I
authors.lastname: Abbate
authors.forename: Federico
authors.initials: F
authors.lastname: Martini
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D018952:Antigens, CD34 / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000145:classification* / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation; D002908:Chronic Disease; D003713:Dendritic Cells / Q000166:cytology* / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006205:Haiti / Q000453:epidemiology; D006801:Humans
chemical_list: D019380:Anti-HIV Agents; D018952:Antigens, CD34