title: Enantioselective synthesis of cyclohepta[b]indoles: gram-scale synthesis of (S)-SIRT1-inhibitor IV.
abstract: An enantioselective gram-scale synthesis of one of the most potent SIRT1-inhibitors has been accomplished by an unprecedented domino reaction sequence establishing the cyclohepta[b]indole core. This method was developed for application in natural product synthesis of a variety of indole alkaloids.
authors.affiliation: Institute of Organic Chemistry, Leibniz University Hannover , Schneiderberg 1, 30167 Hannover, Germany.
authors.forename: Philipp J
authors.initials: PJ
authors.lastname: Gritsch
authors.forename: Erik
authors.initials: E
authors.lastname: Stempel
authors.forename: Tanja
authors.initials: T
authors.lastname: Gaich
mesh_terms: D001688:Biological Products; D002384:Catalysis; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D056564:Sirtuin 1 / Q000032:analysis* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D026121:Indole Alkaloids; D007211:Indoles; D056564:Sirtuin 1