title: Gene transcription in the zebrafish embryo: regulators and networks.
abstract: The precise spatial and temporal control of gene expression is a key process in the development, maintenance and regeneration of the vertebrate body. A substantial proportion of vertebrate genomes encode genes that control the transcription of the genetic information into mRNA. The zebrafish is particularly well suited to investigate gene regulatory networks underlying the control of gene expression during development due to the external development of its transparent embryos and the increasingly sophisticated tools for genetic manipulation available for this model system. We review here recent data on the analysis of cis-regulatory modules, transcriptional regulators and their integration into gene regulatory networks in the zebrafish, using the developing spinal cord as example.
authors.affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Postfach 3640, 76021 Karlsruhe, Germany. Sepand.Rastegar@kit.edu.
authors.forename: Marco
authors.initials: M
authors.lastname: Ferg
authors.forename: Olivier
authors.initials: O
authors.lastname: Armant
authors.forename: Lixin
authors.initials: L
authors.lastname: Yang
authors.forename: Thomas
authors.initials: T
authors.lastname: Dickmeis
authors.forename: Sepand
authors.initials: S
authors.lastname: Rastegar
authors.forename: Uwe
authors.initials: U
authors.lastname: Strähle
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D011499:Protein Processing, Post-Translational / Q000235:genetics; D014158:Transcription, Genetic; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*
keywords: cis-regulatory element; gene regulatory network; genomics; transcription regulator; zebrafish