title: [Differential diagnosis for detection of hyphae in tissue].
abstract: Usually the detection of hyphae in tissue is unmistakable evidence of a deep mycosis requiring antimycotic treatment. Micromorphology alone rarely allows a specific diagnosis, thus confusion is possible between Candida, Aspergillus, Alternaria and Fusarium species or several other fungal agents. If broad, nearly non-septated hyphae are detected histologically mucormycosis can be suspected. Detection of hyphae in tissue is always a cause for concern because therapeutic consequences must follow. Because therapeutic strategies may differ depending on the specific fungal agent, a suspected diagnosis should be supplemented by other methods, e.g. culture of unfixed specimens, by immunohistology or molecular biological methods.
authors.affiliation: Konsiliarlabor für Kryptokokkose, Scedosporiose und importierte Systemmykosen, Robert Koch-Institut, Nordufer 20, 13353, Berlin, Deutschland, TintelnotK@rki.de.
authors.forename: K
authors.initials: K
authors.lastname: Tintelnot
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000473:pathology; D003937:Diagnosis, Differential; D005658:Fungi / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D060585:Fusariosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D060605:Hyalohyphomycosis / Q000473:pathology; D025301:Hyphae / Q000648:ultrastructure*; D016533:Mycological Typing Techniques; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D060446:Phaeohyphomycosis / Q000473:pathology; D011379:Prognosis; D021681:Scedosporium / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents