title: Genetic networks in osseointegration.
abstract: Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.
authors.affiliation: Weintraub Center for Reconstructive Biotechnology, Divisions of Advanced Prosthodontics and Oral Medicine & Biology, UCLA School of Dentistry, Los Angeles, CA 90095-1668.
authors.forename: I
authors.initials: I
authors.lastname: Nishimura
mesh_terms: D015519:Bone Density / Q000235:genetics; D016723:Bone Remodeling / Q000235:genetics; D020219:Chondrogenesis / Q000235:genetics; D002940:Circadian Rhythm / Q000235:genetics; D015921:Dental Implants; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D016348:Osseointegration / Q000235:genetics*; D010012:Osteogenesis / Q000235:genetics; D059467:Transcriptome / Q000235:genetics; D014807:Vitamin D / Q000502:physiology
chemical_list: D015921:Dental Implants; D014807:Vitamin D
keywords: bone remodeling; cartilage matrix protein; circadian rhythm; dental implants; gene expression; microarray analysis