title: Clinical neurogenetics: stroke.
abstract: Understanding the genetic architecture of cerebrovascular disease holds promise of novel stroke prevention strategies and therapeutics that are both safe and effective. Apart from a few single-gene disorders associated with cerebral ischemia or intracerebral hemorrhage, stroke is a complex genetic phenotype that requires careful ascertainment and robust association testing for discovery and validation analyses. The recently uncovered shared genetic contribution between clinically manifest stroke syndromes and closely related intermediate cerebrovascular phenotypes offers effective and efficient approaches to complex trait analysis.
authors.affiliation: Department of Neurology, JP Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA. Electronic address: nrost@partners.org.
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Rost
mesh_terms: D002545:Brain Ischemia / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*
keywords: Cerebrovascular disease; Genetics; Genome-wide association study; Intracerebral hemorrhage; Ischemic stroke; Phenotype; Stroke subtype; White matter hyperintensity