title: Glucose selective surface plasmon resonance-based bis-boronic acid sensor.
abstract: Saccharides - a versatile class of biologically important molecules - are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose.
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. p.m.mendes@bham.ac.uk.
authors.forename: Alex
authors.initials: A
authors.lastname: Stephenson-Brown
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Wang
authors.forename: Parvez
authors.initials: P
authors.lastname: Iqbal
authors.forename: Jon A
authors.initials: JA
authors.lastname: Preece
authors.forename: Yitao
authors.initials: Y
authors.lastname: Long
authors.forename: John S
authors.initials: JS
authors.lastname: Fossey
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
authors.forename: Paula M
authors.initials: PM
authors.lastname: Mendes
mesh_terms: D001665:Binding Sites; D001897:Boronic Acids / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D001897:Boronic Acids; D005947:Glucose