title: Investigation of Crimean-Congo hemorrhagic fever virus transmission from patients to relatives: a prospective contact tracing study.
abstract: We investigated the possibility of transmission of Crimean-Congo hemorrhagic fever (CCHF) virus through respiratory and physical contact. In this prospective study, we traced 116 close relatives of confirmed CCHF cases who were in close contact with the patients during the acute phase of the infection and evaluated the type of contact between patients and their relatives. These relatives were followed for clinical signs or symptoms indicative of CCHF disease, blood samples of those with and without clinical signs were analyzed for CCHF virus immunoglobulin M and G (IgM and IgG, respectively) by enzyme-linked immunosorbent assay. No close relatives developed any signs or symptoms of CCHF and were negative for CCHF virus IgM and IgG. The results suggest that CCHF virus is not easily transmitted from person to person through respiratory or physical contact.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Medical School, Sivas, Turkey; Department of Medical Microbiology, Cumhuriyet University Medical School, Sivas, Turkey.
authors.forename: Mustafa Gokhan
authors.initials: MG
authors.lastname: Gozel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bakir
authors.forename: Atifet Yasemin
authors.initials: AY
authors.lastname: Oztop
authors.forename: Aynur
authors.initials: A
authors.lastname: Engin
authors.forename: Ilyas
authors.initials: I
authors.lastname: Dokmetas
authors.forename: Nazif
authors.initials: N
authors.lastname: Elaldi
mesh_terms: D000293:Adolescent; D000328:Adult; D016358:Contact Tracing / Q000379:methods*; D005190:Family; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology*; D006479:Hemorrhagic Fever, Crimean / Q000635:transmission* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M