title: Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo.
abstract: Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4(+) T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r(2) = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.
authors.affiliation: Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Mohsen
authors.forename: Xutao
authors.initials: X
authors.lastname: Deng
authors.forename: Teri
authors.initials: T
authors.lastname: Liegler
authors.forename: John C
authors.initials: JC
authors.lastname: Guatelli
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Salama
authors.forename: Hussam El-din A
authors.initials: Hel-D
authors.lastname: Ghanem
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
authors.forename: Bruno
authors.initials: B
authors.lastname: Ledergerber
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Wong
authors.forename: Satish K
authors.initials: SK
authors.lastname: Pillai
mesh_terms: D006678:HIV / Q000276:immunology*; D016898:Interferon-alpha / Q000627:therapeutic use*; D012254:Ribavirin / Q000276:immunology; D014779:Virus Replication / Q000276:immunology
chemical_list: D016898:Interferon-alpha; D012254:Ribavirin