title: Genetically engineered humanized mouse models for preclinical antibody studies.
abstract: The use of genetic engineering has vastly improved our capabilities to create animal models relevant in preclinical research. With the recent advances in gene-editing technologies, it is now possible to very rapidly create highly tunable mouse models as needs arise. Here, we provide an overview of genetic engineering methods, as well as the development of humanized neonatal Fc receptor (FcRn) models and their use for monoclonal antibody in vivo studies.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA, gproetzel@earthlink.net.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Proetzel
authors.forename: Michael V
authors.initials: MV
authors.lastname: Wiles
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D005818:Genetic Engineering / Q000379:methods*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D011961:Receptors, Fc / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D011961:Receptors, Fc; C100688:Fc receptor, neonatal