title: Ursodeoxycholic acid induced generalized fixed drug eruption.
abstract: Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3α,7β-dihydroxy-5β-cholanic acid) is used for the treatment of cholestatic liver diseases. Some side effects may be observed, such as diarrhea, dyspepsia, pruritus and headaches. We encountered only three cases of lichenoid reaction regarding the use of UDCA among previous studies. In this article, we reported a generalized FDE case related to UDCA intake in a 59-year-old male patient with cholestasis for the first time in the literature.
authors.affiliation: Department of Dermatology, Faculty of Medicine .
authors.forename: Hatice Uce
authors.initials: HU
authors.lastname: Ozkol
authors.forename: Omer
authors.initials: O
authors.lastname: Calka
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dulger
authors.forename: Gulay
authors.initials: G
authors.lastname: Bulut
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017332:Cetirizine / Q000627:therapeutic use; D002779:Cholestasis / Q000188:drug therapy; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D042882:Gallstones / Q000188:drug therapy; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D011244:Pregnadienediols / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D014580:Ursodeoxycholic Acid / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D039563:Histamine H1 Antagonists, Non-Sedating; D011244:Pregnadienediols; D000068656:Mometasone Furoate; C472067:levocetirizine; D014580:Ursodeoxycholic Acid; D017332:Cetirizine
keywords: Bile acids; generalized fixed drug eruption; ursodeoxycholic acid