title: Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of β-amino esters and anti-HIV drug DPC 083.
authors.affiliation: Department of Chemistry, Key Laboratory of Systems, Bioengineering (The Ministry of Education), State Synergetic, Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072 (P. R. of China), Fax: (+86) 22-2740-3475.
authors.forename: Hai-Na
authors.initials: HN
authors.lastname: Yuan
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D004952:Esters; D007097:Imines / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; C430648:DPC 083; D004952:Esters; D007097:Imines; D008314:Malonates; D009570:Nitriles; D011799:Quinazolines; C542835:ketimine; C030290:malonic acid
keywords: asymmetric catalysis; decarboxylative Mannich reaction; malonic acid half oxyesters; saccharide-derived amino-thioureas; β-amino esters