title: A transcriptional signature for active TB: have we found the needle in the haystack?
abstract: Adithya Cattamanchi and colleagues reflect on recent research by Michael Levin and coworkers into the use of whole blood mRNA expression signatures to detect tuberculosis. The authors highlight challenges faced in getting this promising technology into clinics in low-resource settings. Please see later in the article for the Editors' Summary.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America ; Curry International Tuberculosis Center, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America.
authors.forename: Adithya
authors.initials: A
authors.lastname: Cattamanchi
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Walter
authors.forename: John Z
authors.initials: JZ
authors.lastname: Metcalfe
authors.forename: J Lucian
authors.initials: JL
authors.lastname: Davis
mesh_terms: D015658:HIV Infections / Q000235:genetics*; D006801:Humans; D012313:RNA / Q000235:genetics*; D014376:Tuberculosis / Q000175:diagnosis*
chemical_list: D012313:RNA