title: snoStrip: a snoRNA annotation pipeline.
abstract: BACKGROUND
  Although small nucleolar RNAs form an important class of non-coding RNAs, no comprehensive annotation efforts have been undertaken, presumably because the task is complicated by both the large number of distinct small nucleolar RNA families and their relatively rapid pace of sequence evolution.
  
  
  RESULTS
  With snoStrip we present an automatic annotation pipeline developed specifically for comparative genomics of small nucleolar RNAs. It makes use of sequence conservation, canonical box motifs as well as secondary structure and predicts putative targets.
  
  
  METHODS
  The snoStrip web service and the download version is available at http://snostrip.bioinf.uni-leipzig.de/
authors.affiliation: Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, D-04107 Leipzig, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bartschat
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kehr
authors.forename: Hakim
authors.initials: H
authors.lastname: Tafer
authors.forename: Peter F
authors.initials: PF
authors.lastname: Stadler
authors.forename: Jana
authors.initials: J
authors.lastname: Hertel
mesh_terms: D001483:Base Sequence; D017124:Conserved Sequence / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D020537:RNA, Small Nucleolar / Q000737:chemistry / Q000235:genetics*; D017423:Sequence Analysis, RNA; D012984:Software
chemical_list: D020537:RNA, Small Nucleolar