title: Cannabis 25 (1), biotransformation of cannabidiol and cannabidiolic acid by Pinellia ternata tissue segments.
abstract: Two marihuana constituents, cannabidiol (1) and cannabidiolic acid (4) were each converted mainly to two metabolites using tissue segments of Pinellia ternata tuber. The structures of the metabolites formed from 1 were determined to be 1-Oβ-D-glucopyranoside and 1-Oβ-D-diglucopyranoside by (1)H nmr, (13)C nmr and fabms. Those from 4 were determined as 4-Oβ-D-glucopyranoside and 10'-hydroxyl 4-Oβ-D-glucopyranoside. In time course experiments, 1 was absorbed rapidly by the tissues and glucosylated. Hydroxylation subsequent to the glucosylation occurred at the pentyl group in 4.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, 812, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shoyama