title: Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking.
abstract: Lymphocyte trafficking is a key step in the pathogenesis of various autoimmune diseases. Recruitment of autoreactive lymphocytes to inflamed tissues is a defining feature of numerous persistent organ-specific autoimmune conditions and various therapies are now used in several of these diseases which appear to specifically block lymphocyte migration. Thus, better understanding of the molecular events involved in homing of autoreactive pathogenic lymphocytes may present novel opportunities for pharmacological intervention in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type-1 diabetes and psoriasis. This review describes recent progress in understanding lymphocyte trafficking in autoimmunity, focusing on the involvement of the chemokine and chemokine receptor superfamily. Possible strategies to improve therapeutics for autoimmune diseases arising from these studies are discussed.
authors.affiliation: Chemokine Biology Laboratory, School of Molecular and Biomedical Science, Centre for Molecular Pathology, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: Iain
authors.initials: I
authors.lastname: Comerford
authors.forename: Ervin E
authors.initials: EE
authors.lastname: Kara
authors.forename: Duncan R
authors.initials: DR
authors.lastname: McKenzie
authors.forename: Shaun R
authors.initials: SR
authors.lastname: McColl
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002465:Cell Movement; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D018925:Chemokines
keywords: T cells; autoimmunity; cell migration; chemokines; lymphocytes