title: SPECT and 18F-FDG PET/CT imaging of multiple paragangliomas and a growth hormone-producing pituitary adenoma as phenotypes from a novel succinate dehydrogenase subunit D mutation.
abstract: Mutations in the subunits B, C, D, and recently in A of the succinate dehydrogenase have been associated with the development of paragangliomas. We report the case of a 37-year-old man presented with multiple paragangliomas and a growth hormone-producing pituitary adenoma, with a novel succinate dehydrogenase subunit D mutation as the genetic analysis revealed. We present the similarities and the differences of the findings in patient imaging with either methods of SPECT (I-MIBG and In-pentetreotide) or PET/CT with F-FDG. This case revealed that F-FDG PET/CT detected more lesions and was superior compared with the other methods.
authors.affiliation: From the *Department of Nuclear Medicine, Evangelismos General Hospital, Athens, Greece; †Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; and ‡Division of Endocrinology and Metabolism, Hippocrateion General Hospital, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Skoura
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Datseris
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Xekouki
authors.forename: Georgios
authors.initials: G
authors.lastname: Tolis
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D000328:Adult; D019788:Fluorodeoxyglucose F18; D013006:Growth Hormone / Q000096:biosynthesis; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009154:Mutation; D010235:Paraganglioma / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D049268:Positron-Emission Tomography; D021122:Protein Subunits / Q000235:genetics; D013385:Succinate Dehydrogenase / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D021122:Protein Subunits; D019788:Fluorodeoxyglucose F18; D013006:Growth Hormone; D013385:Succinate Dehydrogenase