title: Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population.
abstract: Colorectal cancer (CRC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with CRC in the Han population. In this Han Chinese case-control study, we genotyped 203 CRC cases and 296 controls using Sequenom MassARRAY technology and analyzed their associations with CRC using χ(2) tests, SNPStats software, and SHEsis software. Based on χ(2) tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk. In the genetic model analyses, we found the genotype "CC" of rs3802842 in C11orf92-C11orf93 may significantly increase CRC risk in the recessive model (p = 0.0071), whereas "GT" of rs17109928 in NOC3L may decrease the risk in the over-dominant model (p = 0.0091). Using SHEsis software, we found PLCE1 and NOC3L are strongly linked, and the "GCCATTCTGTC" haplotype may increase the risk of CRC (p = 0.049). We found three genes (PLCE1, C11orf92-C11orf93, and NOC3L) are associated with CRC susceptibility. In combination with previous reports, our results suggest that these genes may be associated with CRC in the Han population.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Duan
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.forename: Huiling
authors.initials: H
authors.lastname: Lou
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Shanqu
authors.initials: S
authors.lastname: Li
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Long
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics*; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012313:RNA; D012307:Risk Factors
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D054801:Phosphoinositide Phospholipase C; D012313:RNA; C588266:COLCA1 protein, human; C588267:POU2AF3 protein, human; C502216:NOC3L protein, human; C423320:phospholipase C epsilon