title: Effects of chronic low-dose cadmium exposure on selected biochemical and antioxidant parameters in rats.
abstract: The effects of long-term (1 yr) exposure to low doses of cadmium (Cd) dissolved in drinking water on selected biochemical and antioxidant parameters were studied in Wistar rats. Rats were divided into four groups: male control group (C-m), female control group (C-f), male Cd-exposed group (Cd-m), and female Cd-exposed group (Cd-f). Cd groups were exposed to Cd dissolved in drinking water (cadmium dichloride 4.8 mg CdCl2/L, i.e., 2.5 mg Cd/L, 500-fold of maximal allowable concentration for potable water). The experiment was terminated on d 370. In all groups, biochemical parameters (total protein [TP], albumin, alanine aminotransferase, aspartate aminotransferase, glucose, cholesterol, triacylglycerols, urea, and creatinine) and antioxidant parameters (glutathione peroxidase, superoxide dismutase, and total antioxidant capacity) were measured in the blood. Total protein and albumin concentrations were decreased significantly in the Cd-m group. Other biochemical parameters did not change in Cd groups compared to control groups. Superoxide dismutase fell significantly in both male and female Cd-exposed groups. Activity of glutathione peroxidase was markedly lower in Cd-exposed groups. Total antioxidant capacity increased significantly in Cd-f group. These results suggest that chronic low-dose oral Cd exposure induces oxidative stress.
authors.affiliation: a Department of Pathological Physiology, Faculty of Medicine , P. J. Šafárik University , Košice , The Slovak Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Lovásová
authors.forename: Oliver
authors.initials: O
authors.lastname: Rácz
authors.forename: Iveta
authors.initials: I
authors.lastname: Cimboláková
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Nováková
authors.forename: Peter
authors.initials: P
authors.lastname: Dombrovský
authors.forename: František
authors.initials: F
authors.lastname: Ništiar
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001806:Blood Urea Nitrogen; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000032:analysis / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D019187:Cadmium Compounds; D012709:Serum Albumin; D014280:Triglycerides; D003404:Creatinine; D009195:Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D019256:Cadmium Chloride