title: Therapeutic gene delivery using bioreducible polymers.
abstract: Bioreducible polymers, which can be degraded in reducing environment due to the cleavage of internal disulfide bonds, have been developed for gene delivery systems. They show high stability in extracellular physiological condition and cytoplasm-specific release of genetic materials, as well as decreased cytotoxicity because cytoplasm is a reducing environment containing high level of reducing molecules such as glutathione. Based on these advantages, recently, many bioreducible polymers have been further investigated with therapeutic genes for the treatment of diseases and demonstrated promising results. This review will focus on the therapeutic gene delivery using bioreducible polymers and the evaluation of therapeutic efficacy for cancer, myocardial infarction, diabetes and miscellaneous diseases.
authors.affiliation: Department of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151-921, Korea.
authors.forename: Kitae
authors.initials: K
authors.lastname: Ryu
authors.forename: Tae-Il
authors.initials: TI
authors.lastname: Kim
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D034622:RNA Interference
chemical_list: D011108:Polymers; D012313:RNA; D004247:DNA