title: [Function of peripheral blood Th17 cells in patients with multiple myeloma].
abstract: This study was aimed to investigate the effects of peripheral blood Th17 cells and their secreting IL-17, IL-21 in the occurrence and development of multiple myeloma (MM). A total of 55 patients with MM were divided into non-remission group (group A , n = 30), remission group (group B, n = 25); healthy volunteers were used as control group (group C , n = 30). The concentration of IL-17, IL-21 and IL-6 in the peripheral blood mononuclear cell (PBMNC) culture supernatant were determined with ELISA. The ratio of Th7 cells in PBMNC was determined by flow cytometry. The results showed that IL-17, IL-21 levels and ratio of Th17 cells in group A were much higher than those in group B and C (P < 0.05), IL-17, IL-21 and the ratio of Th17 cells between group B and group C were not significantly different (P > 0.05); IL-17 level in non-remission MM group positively correlated with IL-6 level (r = 0.782, P < 0.05), IL-21 level in non-remission MM group positively correlated with IL-6 level (r = 0.778, P < 0.05). It is concluded that Th17 cells as a initiating factor may be involved in the immune pathogenesis of MM patients, promoting the progress of the disease.
authors.affiliation: Department of Hematology, Shanghai Jiaotong University Sixth people's Hospital, Shanghai 200233, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lu-Xi
authors.initials: LX
authors.lastname: Song
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Xiao
authors.forename: Chun-Kang
authors.initials: CK
authors.lastname: Chang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D058504:Th17 Cells / Q000378:metabolism*; D000098546:Interleukin-21
chemical_list: D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; D000098546:Interleukin-21