title: Effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia.
  
  
  METHODS
  A total of 138 male LUTS patients aged more than 50 years with an International Prostate Symptom Score (IPSS) ≥8 were enrolled in this open-label, multicenter, prospective, noncomparative observational study. Clinical assessments included IPSS, quality of life (QoL) index, International Index of Erectile Function (IIEF), Danish Prostate Symptom Score (DAN-PSS), and an early morning erection questionnaire. The data were recorded at baseline and at 1 and 3 months after treatment with tamsulosin 0.2 mg/d. Adverse events were analyzed in all patients.
  
  
  RESULTS
  During the study period of 3 months, the IPSS and QoL index significantly improved from baseline by -11.40±9.40 and -1.11±1.36, respectively (p<0.001). However, there were no clinically relevant changes in total IIEF score (mean difference, 1.63±15.50; p=0.406) or the 5 subdomains (p>0.05). Furthermore, DAN-PSS weighted scores (A×B) showed no clinically relevant changes (mean difference on Q1, Q2, and Q3: -0.45±2.94, 0.27±2.50, and -1.27±2.27, p>0.05). In addition, there were no clinically significant changes in responses on the early morning erection questionnaire.
  
  
  CONCLUSIONS
  Tamsulosin at the dose of 0.2 mg significantly improved the IPSS and the QoL index compared with baseline. However, tamsulosin did not exhibit any significant impact on sexual function or any negative impact on ejaculatory function.
authors.affiliation: Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: Sin Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Wan Cheol
authors.initials: WC
authors.lastname: Lee
authors.forename: Ma Tae
authors.initials: MT
authors.lastname: Kim
authors.forename: Kyungtae
authors.initials: K
authors.lastname: Ko
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Lee
authors.forename: Choong-Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Je Jong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Dae Yul
authors.initials: DY
authors.lastname: Yang
keywords: Ejaculation; Erectile dysfunction; Lower urinary tract symptoms; Prostatic hyperplasia; Tamsulosin