title: Prognostic value of six minute walk test in cystic fibrosis adults.
abstract: BACKGROUND
  The 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist in cystic fibrosis (CF) adults.
  
  
  METHODS
  Consecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off 6 min walking distance (6MWD) value that best predicted a combined endpoint (death without transplant or lung transplant) was established using a receiver operating curve. Determinants of low 6MWD or of desaturation (SpO2 ≤ 90%) during 6MWT were examined using multivariate logistic regressions. Prognostic value of these variables was assessed using Kaplan-Meier and Cox analyses.
  
  
  RESULTS
  6MWT was performed in 286 CF adults (median: age, 28 yr; FEV1, 45% predicted) of whom 14% (n = 40) had lung transplant and 6% (n = 18) died without transplant. 6MWD correlated with FEV1% predicted (r = 0.43; P < 0.001), but markedly differed in subjects within the same range of FEV1. A 6MWD ≤ 475 m predicted death or transplant and was mostly found in patients with FEV1 ≤ 60% predicted. Desaturation during the 6MWT occurred in 29% of patients, exclusively in subjects with FEV1 ≤ 60% predicted. Both 6MWD ≤ 475 m and desaturation during the 6MWT were independent predictors of death or transplant.
  
  
  CONCLUSIONS
  The 6MWT provides prognostic information in CF adults, especially in subjects with FEV1 ≤ 60% predicted.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France; Department of Respiratory Medicine and Adult Cystic Fibrosis Center, Hôpital Cochin, AP-HP, 75014 Paris, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Martin
authors.forename: Jeanne
authors.initials: J
authors.lastname: Chapron
authors.forename: Dominique
authors.initials: D
authors.lastname: Hubert
authors.forename: Reem
authors.initials: R
authors.lastname: Kanaan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Honoré
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Paillasseur
authors.forename: Frédérique
authors.initials: F
authors.lastname: Aubourg
authors.forename: Anh-Tuan
authors.initials: AT
authors.lastname: Dinh-Xuan
authors.forename: Daniel
authors.initials: D
authors.lastname: Dusser
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fajac
authors.forename: Pierre-Régis
authors.initials: PR
authors.lastname: Burgel
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood / Q000401:mortality / Q000503:physiopathology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D010100:Oxygen / Q000097:blood; D011379:Prognosis; D012372:ROC Curve; D016138:Walking / Q000502:physiology
chemical_list: D010100:Oxygen
keywords: 6 min walk test; Adults; Cystic fibrosis; Prognosis