title: Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells.
abstract: Pancreatic cancer is one of the leading causes of cancer-related death in the world. It is very urgent to find new therapeutic targets and improve the treatment. Cyclooxygenase 2 (Cox2), a regulator of inflammation signaling, has been found to be involved in tumorigenesis of various tumor types. However, its biological functions in pancreatic cancer cells are not fully understood. Here, we found that the expression of Cox2 was elevated in pancreatic cancer tissues compared with that in the paired normal tissues. The over-expression of Cox2 in pancreatic cancer cells promoted cell proliferation and migration, while the knockdown of the expression of Cox2 inhibited the tumorigenesis of pancreatic cancer cells in vitro and in vivo. Mechanistically, Cox2 regulated the expression of multiple genes involved in cell growth, migration, and cell apoptosis. Taken together, our study revealed the pivotal function of Cox2 in pancreatic cancer, and Cox2 might be an important therapeutic target for the treatment.
authors.affiliation: Department of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: Zhengfa
authors.initials: Z
authors.lastname: Mao
authors.forename: Xin
authors.initials: X
authors.lastname: Fan
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.forename: Xuqing
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D064593:Heterografts; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D051379:Mice; D008819:Mice, Nude; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D034741:RNA, Small Interfering; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection; D015854:Up-Regulation
chemical_list: D034741:RNA, Small Interfering; D051546:Cyclooxygenase 2