title: Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece.
abstract: Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate analysis using age, height, weight and smoking status as covariates, as well as the Mann-Whitney non-parametric test, revealed a strong trend of association of the T allele with high propofol concentrations determined in whole blood, shortly after a single bolus dose. Propofol concentrations which were higher than one standard deviation of the mean were almost invariably associated with carriage of the T allele.
authors.affiliation: Department of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki.
authors.forename: Orthodoxia
authors.initials: O
authors.lastname: Mastrogianni
authors.forename: Emma
authors.initials: E
authors.lastname: Gbandi
authors.forename: Amvrosios
authors.initials: A
authors.lastname: Orphanidis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Raikos
authors.forename: Evangelia
authors.initials: E
authors.lastname: Goutziomitrou
authors.forename: Efstratios M
authors.initials: EM
authors.lastname: Kolibianakis
authors.forename: Basil C
authors.initials: BC
authors.lastname: Tarlatzis
authors.forename: Antonis
authors.initials: A
authors.lastname: Goulas
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D001711:Biotransformation; D065702:Cytochrome P-450 CYP2B6 / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005838:Genotype; D006115:Greece; D006801:Humans; D007275:Injections, Intravenous; D054315:Oocyte Retrieval; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D015742:Propofol / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D012737:Sex Factors
chemical_list: D018686:Anesthetics, Intravenous; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D015742:Propofol