title: Primary mucoepidermoid carcinoma of the breast: a case report with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas.
abstract: Mucoepidermoid carcinomas in mammary glands represent 0.3% of all breast tumors. Features of salivary gland mucoepidermoid carcinoma have been used in studies concerning mucoepidermoid carcinomas of the breast because both share similar morphologic and molecular features. We report a case of primary mucoepidermoid carcinoma of the breast with an immunohistochemistry staining panel. We verified that MUC5AC occurs in more than 50% of high-grade tumors, and MUC1 correlates with shorter disease-free survival. The comparative analysis of mucin profiles may provide further insights into the clinical behavior of these tumors.
authors.affiliation: Alfredo Ribeiro-Silva, Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Bairro Monte Alegre, 14049-900, Ribeirão Preto, São Paulo, Brazil, tel. 55 16 3602 3172, fax 55 16 3633 1068, e-mail: arsilva@fmrp.usp.br.
authors.forename: Maria Heloisa Rached
authors.initials: MH
authors.lastname: Palermo
authors.forename: Michelli Barbara
authors.initials: MB
authors.lastname: Pinto
authors.forename: Juliana Silva
authors.initials: JS
authors.lastname: Zanetti
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ribeiro-Silva
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor