title: The role of the kidney in protein metabolism: the capacity of tubular lysosomal proteolysis in nephrotic syndrome.
abstract: The kidneys play an important role in protein metabolism. Renal tubules reabsorb 3 g of albumin under normal conditions, and exhibit a 6-fold increase in the reabsorption of albumin in patients with focal segmental glomerulosclerosis. The capacity of tubular lysosomal proteolysis can be increased up to 8-fold; however, proteinuria over the capacity of tubular handling may cause tubulointerstitial damage in patients with nephrotic syndrome.
authors.affiliation: Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tojo
mesh_terms: D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*
chemical_list: D010447:Peptide Hydrolases