title: A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus.
abstract: Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the novel avian-origin H7N9 virus responsible for an outbreak in China. We also show that the internal segments of this precursor strain are closely related to those of the presumed precursor for the HA segment, A/duck/Zhejiang/12/2011(H7N3), which indicates that the sources of both HA and NA donors for the reassortant virus are of regional and not migratory-bird origin and highlights the role of chicken already in the early reassortment events.
authors.forename: Raphael Tze Chuen
authors.initials: RT
authors.lastname: Lee
authors.forename: Vithiagaran
authors.initials: V
authors.lastname: Gunalan
authors.forename: Thanh Dac
authors.initials: TD
authors.lastname: Van
authors.forename: Ly Thi
authors.initials: LT
authors.lastname: Le
authors.forename: Frank
authors.initials: F
authors.lastname: Eisenhaber
authors.affiliation: Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), 30 Biopolis Street, #07-01, Matrix Building, 138671 Singapore, Singapore. sebastianms@bii.a-star.edu.sg.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Maurer-Stroh
mesh_terms: D000818:Animals; D002645:Chickens; D002681:China; D064766:Influenza A Virus, H7N9 Subtype / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D005585:Influenza in Birds / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology*; D017422:Sequence Analysis, DNA