title: [Stress and cell communication between bone cells].
abstract: Bone is constantly renewed by the balanced action of bone formation and bone resorption both of which mainly occur at the bone surface. This restructuring process called "bone remodeling" is important not only for normal bone mass and strength, but also for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone component cells such as osteoclasts, osteoblasts and osteocytes. An imbalance of this process is often linked to various bone diseases. During bone remodeling, resorption by osteoclasts precedes bone formation by osteoblasts. Based on the osteocyte location within the bone matrix and the cellular morphology, it is proposed that osteocytes potentially contribute to the controls of bone remodeling as well as sensing mechanical stress.
authors.affiliation: Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University/JST, PPESTO Program, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000235:genetics* / Q000502:physiology*; D001862:Bone Resorption / Q000235:genetics* / Q000503:physiopathology; D002450:Cell Communication / Q000235:genetics* / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics; D016326:Extracellular Matrix Proteins; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology; D010011:Osteocytes / Q000502:physiology*; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D053245:RANK Ligand; D013314:Stress, Mechanical; D060449:Wnt Signaling Pathway
chemical_list: C513308:Dmp1 protein, mouse; D016326:Extracellular Matrix Proteins; D053245:RANK Ligand