title: Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis.
abstract: OBJECTIVE
  Interleukin-1 beta (IL-1β) has been implicated in the pathophysiology of schizophrenia. To assess whether the IL1B gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis.
  
  
  METHODS
  We tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers, including common tagging single nucleotide variations (SNVs) and a rare non-synonymous variation detected by resequencing the coding regions. We also performed a meta-analysis of rs16944 using a total of 8724 case-control and 201 trio samples from 16 independent populations.
  
  
  RESULTS
  We found no significant associations between any of the 12 SNVs examined and schizophrenia in either case-control or trio samples. Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
  
  
  CONCLUSIONS
  The present study does not support a role for IL1B in schizophrenia susceptibility.
authors.forename: Masako
authors.initials: M
authors.lastname: Shibuya
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Ayako
authors.initials: A
authors.lastname: Nunokawa
authors.forename: Jun
authors.initials: J
authors.lastname: Egawa
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kaneko
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Igeta
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta