title: Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides.
abstract: A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.
authors.affiliation: Laboratory of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, 130022 Jilin, People's Republic of China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Xin
authors.forename: Dexuan
authors.initials: D
authors.lastname: Xiang
authors.forename: Jiming
authors.initials: J
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Fenguo
authors.initials: F
authors.lastname: Zhou
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000178:Acrylamides; D009570:Nitriles; D009942:Organometallic Compounds; D003300:Copper; C000945:dicyanmethane