title: Assessment of the effect of casein phosphopeptide-amorphous calcium phosphate on postoperative sensitivity associated with in-office vital tooth whitening.
abstract: The aim of this study was to evaluate the efficacy of tooth mousse containing 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in reducing tooth sensitivity associated with in-office vital tooth whitening. In-office tooth whitening was performed for 51 participants using 35% hydrogen peroxide gel in a single visit. After the procedure, each participant was randomly assigned to one of three groups: gel without desensitizing agent (n=17), gel with 2% sodium fluoride (n=17), gel with 10% CPP-ACP (n=17). A small amount of the desensitizing gel assigned for each participant was applied directly on the labial surfaces of teeth and left undisturbed for three minutes. The participants were asked to apply the gel assigned to them for three minutes twice daily after brushing their teeth, and to continue this for 14 days. The participants were asked to return for follow-up visits after 24 hours and on days 3, 7, and 14, at which time teeth shade changes were assessed by one evaluator using a value-oriented Vita classic shade guide. The incidence, duration, and intensity of tooth sensitivity experienced was self-assessed on a daily basis for the 14-day study period using a visual analog scale (VAS). The effect of the three gels on tooth sensitivity was assessed using one-way analysis of variance and a χ (2) test (α=0.05). The general linear model was used to compare intensity-level differences in the three studied groups and for shade stability over the follow-up period. The results of this study showed that all three gels decreased the intensity of sensitivity associated with tooth whitening. The intensity of sensitivity was lower in the fluoride group than in the other two groups; however, it was not statistically significant (p=0.112 and p=0.532 on day 1 and day 2, respectively). The average shade change was 6.8. None of the tested materials affected the efficacy of tooth whitening, but the shade change among the fluoride group showed more color stability than that of the other two groups. This study suggested that using a gel after tooth whitening can reduce the intensity of tooth sensitivity associated with in-office whitening procedures without affecting the efficiency of tooth whitening. However, it failed to demonstrate that using a 10% CPP-ACP could provide additional therapeutic benefits.
authors.forename: G A
authors.initials: GA
authors.lastname: Maghaireh
authors.forename: H
authors.initials: H
authors.lastname: Alzraikat
authors.forename: A
authors.initials: A
authors.lastname: Guidoum
mesh_terms: D000293:Adolescent; D000328:Adult; D002364:Caseins / Q000008:administration & dosage / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D014073:Tooth Bleaching / Q000009:adverse effects / Q000379:methods*; D058205:Tooth Bleaching Agents / Q000009:adverse effects / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D002364:Caseins; D058205:Tooth Bleaching Agents; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex