title: Pancytopenia due to lepromatous involvement of the bone marrow: successful treatment with multidrug therapy.
abstract: Leprosy is a chronic infectious disease with a wide spectrum of signs and symptoms depending on the ability of the host's immune system to resist the infection. The disease is frequently associated with sensory loss in skin lesions and damage in peripheral nerve trunks leading to nerve function impairment. In lepromatous leprosy, the immune system offers no protection against the multiplying bacilli and this results in heavy infiltration of the internal organs. We report a case of florid lepromatous leprosy with bone marrow suppression due to the disease, presenting with anemia, leukocytopenia and thrombocytopenia. The hematological abnormalities were fully reversed by mutidrug therapy for leprosy. We suggest that infiltration of the bone marrow by Mycobacterium leprae can cause pancytopenia, which can be cured by treatment of the leprosy alone.
authors.affiliation: Department of Dermatology and Venereology, Medical College, Calicut, Kerala, India. mpbinitha@gmail.com
authors.forename: Manikoth Payyanadan
authors.initials: MP
authors.lastname: Binitha
authors.forename: Sasidharanpillai
authors.initials: S
authors.lastname: Saritha
authors.forename: Najeeba
authors.initials: N
authors.lastname: Riyaz
authors.forename: Vineetha
authors.initials: V
authors.lastname: Mary
mesh_terms: D001855:Bone Marrow Diseases / Q000097:blood* / Q000382:microbiology* / Q000473:pathology; D005121:Extremities / Q000382:microbiology / Q000473:pathology; D005145:Face / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D010198:Pancytopenia / Q000382:microbiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D007917:Leprostatic Agents