title: Near full-length genome characterization of a new CRF01_AE/CRF08_BC recombinant transmitted between a heterosexual couple in Guangxi, China.
abstract: Human immunodeficiency virus type 1 (HIV-1) subtype CRF01_AE is transmitted mainly by sexual activity in Guangxi, southwestern China. Other subtypes, including CRF07_BC, CRF08_BC, and subtype B, are also prevalent in this region. Cocirculation of multiple subtypes, as well as a high rate of drug use, creates favorable conditions for the emergence of recombinant viruses in Guangxi. In the present study, we identified a new HIV-1 unique recombinant form (CRF01_AE /08BC) transmitted from the infected index patient to his seronegative sexual partner. This is the first near full-length genome characterization of a CRF01_AE /08BC recombinant virus in Guangxi, and provides an important basis for future analysis on potential new recombinant transmission events.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Nidan
authors.initials: N
authors.lastname: Wang
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.forename: Runsong
authors.initials: R
authors.lastname: Xiong
authors.forename: Hongman
authors.initials: H
authors.lastname: Zhang
authors.forename: Jenny H
authors.initials: JH
authors.lastname: Hsi
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Ning
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D002681:China; D005191:Family Characteristics; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA