title: Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.
abstract: Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Yamashita
authors.forename: Kei
authors.initials: K
authors.lastname: Kawana
authors.forename: Kensuke
authors.initials: K
authors.lastname: Tomio
authors.forename: Ayumi
authors.initials: A
authors.lastname: Taguchi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Isobe
authors.forename: Ryo
authors.initials: R
authors.lastname: Iwamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Masuda
authors.forename: Hitomi
authors.initials: H
authors.lastname: Furuya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagamatsu
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nagasaka
authors.forename: Takahide
authors.initials: T
authors.lastname: Arimoto
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Oda
authors.forename: Osamu
authors.initials: O
authors.lastname: Wada-Hiraike
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taketani
authors.forename: Jing X
authors.initials: JX
authors.lastname: Kang
authors.forename: Shiro
authors.initials: S
authors.lastname: Kozuma
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Makoto
authors.initials: M
authors.lastname: Arita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osuga
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D015994:Incidence; D018836:Inflammation Mediators / Q000378:metabolism; D050356:Lipid Metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D051379:Mice; D023421:Models, Animal; D009215:Myometrium / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: C583424:17,18-dihydroxyeicosapentaenoic acid; D016207:Cytokines; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators