title: Immune responses to pertussis vaccines and disease.
abstract: In this article we discuss the following: (1) acellular vaccines are immunogenic, but responses vary by vaccine; (2) pertussis antibody levels rapidly wane but promptly increase after vaccination; (3) whole-cell vaccines vary in immunogenicity and efficacy; (4) whole-cell vaccines and naturally occurring pertussis generate predominantly T-helper 1 (Th1) responses, whereas acellular vaccines generate mixed Th1/Th2 responses; (5) active transplacental transport of pertussis antibody is documented; (6) neonatal immunization with diphtheria toxoid, tetanus toxoid, and acellular pertussis vaccine has been associated with some suppression of pertussis antibody, but suppression has been seen less often with acellular vaccines; (7) memory B cells persist in both acellular vaccine- and whole cell vaccine-primed children; and (8) in acellular vaccine-primed children, T-cell responses remain elevated and do not increase with vaccine boosters, whereas in whole-cell vaccine-primed children, these responses can be increased by vaccine boosting and natural exposure. Despite these findings, challenges remain in understanding the immune response to pertussis vaccines.
authors.affiliation: Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics, School of Medicine, and.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
authors.forename: Guy A M
authors.initials: GA
authors.lastname: Berbers
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D010567:Pertussis Vaccine / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D022282:Vaccines, Acellular / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular; D015164:Vaccines, Inactivated
keywords: DTaP; DTwP; acellular pertussis vaccines; pertussis vaccines; whole cell pertussis vaccines