title: Historical aspects of Potomac horse fever in Ontario (1924-2010).
abstract: In the summer of 1924 Dr. Frank W. Schofield conducted investigations into an endemic disease of horses in the Kent and Essex counties of Ontario. According to farmers in these counties the disease had existed in this region for at least 50 years previously. The clinical, pathological, histopathological, and epidemiological findings outlined in Schofield's detailed report strongly suggest that this endemic disease was what was designated in 1979 as "Potomac horse fever" (PHF). This assumption is further substantiated by transmission experiments involving horses and laboratory animals that were conducted by Schofield utilizing horse feces, whole blood, and mayflies. The aim of this paper is to present Schofield's detailed investigations and findings and to compare these with PHF research conducted from 1979 to 2010 that ultimately led to the discovery of Neorickettsia risticii as the etiological agent and to elucidation of the organism's complex life cycle.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: John D
authors.initials: JD
authors.lastname: Baird
authors.forename: Luis G
authors.initials: LG
authors.lastname: Arroyo
mesh_terms: D000711:Anaplasmataceae Infections / Q000453:epidemiology / Q000266:history / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006734:Horse Diseases / Q000453:epidemiology* / Q000266:history* / Q000382:microbiology; D006736:Horses; D041103:Neorickettsia risticii / Q000302:isolation & purification*