title: Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing.
abstract: We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment.
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Re
authors.forename: Davide
authors.initials: D
authors.lastname: Contini
authors.forename: Massimo
authors.initials: M
authors.lastname: Turola
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spinelli
authors.forename: Lucia
authors.initials: L
authors.lastname: Zucchelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Caffini
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Cubeddu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Torricelli
keywords: (120.3890) Medical optics instrumentation; (170.1470) Blood or tissue constituent monitoring; (170.1610) Clinical applications; (170.2655) Functional monitoring and imaging; (170.3890) Medical optics instrumentation; (170.5280) Photon migration; (170.6920) Time-resolved imaging