title: The effect of blood flow on magnetic resonance imaging of non thermal irreversible electroporation.
abstract: To generate an understanding of the physiological significance of MR images of Non-Thermal Irreversible Electroporation (NTIRE) we compared the following MR imaging sequences: T1W, T2W, PD, GE, and T2 SPAIR acquired after NTIRE treatment in a rodent liver model. The parameters that were studied included the presence or absence of a Gd-based contrast agent, and in vivo and ex-vivo NTIRE treatments in the same liver. NTIRE is a new minimally invasive tissue ablation modality in which pulsed electric fields cause molecularly selective cell death while, the extracellular matrix and large blood vessels remain patent. This attribute of NTIRE is of major clinical importance as it allows treatment of undesirable tissues near critical blood vessels. The presented study results suggest that MR images acquired following NTIRE treatment are all directly related to the unique pattern of blood flow after NTIRE treatment and are not produced in the absence of blood flow.
authors.affiliation: 1] Center for Bioengineering in the Service of Humanity and Society, School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel [2] The Medical Imaging Department, Al Quds University/Abu Dis Jerusalem, Tel-Aviv, Israel.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hjouj
authors.forename: Jacob
authors.initials: J
authors.lastname: Lavee
authors.forename: David
authors.initials: D
authors.lastname: Last
authors.forename: David
authors.initials: D
authors.lastname: Guez
authors.forename: Dianne
authors.initials: D
authors.lastname: Daniels
authors.forename: Shirley
authors.initials: S
authors.lastname: Sharabi
authors.forename: Boris
authors.initials: B
authors.lastname: Rubinsky
authors.forename: Yael
authors.initials: Y
authors.lastname: Mardor
mesh_terms: D000818:Animals; D018274:Electroporation / Q000379:methods; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D012039:Regional Blood Flow