title: A new enantioselective synthesis of the anticonvulsant drug pregabalin (Lyrica) based on a hydrolytic kinetic resolution method.
abstract: A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mujahid
authors.forename: Murugan
authors.initials: M
authors.lastname: Muthukrishnan
mesh_terms: D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry; D040761:Biomimetic Materials; D004852:Epoxy Compounds / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D000069583:Pregabalin; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000927:Anticonvulsants; D004852:Epoxy Compounds; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid
keywords: anticonvulsant drug; hydrolytic kinetic resolution; pregabalin