title: Lipid Profile Parameters under influence of Periodontitis Associated with Chronic Stress: An Animal Model Study.
abstract: BACKGROUND
  The present study compared the effect of two chronic stress models associated with periodontitis induced in rats on partial lipid profile parameters.
  
  
  METHODS
  Forty-eight rats were divided into 4 groups: physical stress+periodontitis, variable stress+periodontitis, periodontitis and control. Physical stress and variable stress occurred over 60 days. After the first ten days of the stress test, periodontitis was induced by ligature. After 60 days of experimentation, the animals underwent incision and visualization of the posterior vena cava, and blood punctures were performed under a vacuum. Impartial and trained examiners performed the analysis of the parameters: low-density lipoprotein, high density lipoprotein, triglycerides and cholesterol.
  
  
  RESULTS
  The lipid parameters and cholesterol were significantly lower in the variable stress group than in the ligature and control groups. The physical stress group was not statistically different from the other groups. The triglyceride level was highest for the control group and statistically different from the levels in groups variable stress and physical stress. The physical stress group had the lowest triglyceride level, which was statistically different from that of the control group. There was no statistical difference between physical stress and variable stress with respect to low-density lipoprotein; a similar finding was obtained for ligature and control. The variable stress group had the lowest low-density lipoprotein level, which was statistically different from those of the ligature and control groups. High density lipoprotein levels showed no statistical differences between groups.
  
  
  CONCLUSIONS
  Despite the limitations of the methodology, it seems that the stress model variable associated with periodontitis improved lipid parameters in the study. How to cite this article:Porto AN, Borges AH, Segundo AS, Semenoff TA, Pedro FL, Bandeca MC, Cortelli SC. Lipid profile parameters under influence of periodontitis associated with chronic stress: an animal model study. J Int Oral Health 2013; 5(4):8-14.
authors.affiliation: Masters Program in Integrated Dental Sciences, University of Cuiaba Cuiaba, MT, Brazil.
authors.forename: Alessandra Nogueira
authors.initials: AN
authors.lastname: Porto
authors.forename: Alvaro Henrique
authors.initials: AH
authors.lastname: Borges
authors.forename: Alex
authors.initials: A
authors.lastname: Semenoff-Segundo
authors.forename: Tereza Aparecida
authors.initials: TA
authors.lastname: Semenoff
authors.forename: Fábio Luis Miranda
authors.initials: FL
authors.lastname: Pedro
authors.forename: Matheus Coelho
authors.initials: MC
authors.lastname: Bandeca
authors.forename: Sheila Cavalca
authors.initials: SC
authors.lastname: Cortelli
keywords: Metabolism lipid; periodontitis; rat; stress