title: Terbium-based coordination polymer nanoparticles for detection of ciprofloxacin in tablets and biological fluids.
abstract: The metal-organic coordination polymers with tunable structures and properties have been rapidly emerging as very important functional materials. In this work, we prepared terbium (Tb(3+))-based coordination polymer nanoparticles (CPNPs) by employing adenine (Ad) as bridging ligands. The CPNPs was further used as a receptor reagent for ciprofloxacin (CF) detection in aqueous solution. Addition of CF induces a typical emission of Tb(3+) due to the formation of Ad/Tb-CF complex and the sensitization of CF. The fluorescent intensity of Tb(3+) was enhanced linearly with increasing the CF concentration from 60 nM to 14 μM. The detection limit for CF in aqueous solution is 60 nM. The Ad/Tb CPNPs was successfully applied to detect CF in tablet and urine samples and showed a satisfactory result. Compared with other methods, the proposed method is advantageous because that it provides a very simple strategy for CF detection, which does not require complicated sample pretreatment processes or special reaction media. The proposed strategy could be contributed to expand the potential applications of lanthanide coordination polymers in biological and environmental fields.
authors.affiliation: Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Key Laboratory of Chemical Biology, Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, P. R. China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Tan
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Chanjiao
authors.initials: C
authors.lastname: Ma
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Song
authors.forename: Fugang
authors.initials: F
authors.lastname: Xu
authors.forename: Shouhui
authors.initials: S
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000225:Adenine / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000652:urine; D002939:Ciprofloxacin / Q000032:analysis / Q000652:urine; D053758:Nanoparticles / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013725:Terbium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D013725:Terbium; D002939:Ciprofloxacin; D000225:Adenine