title: Clinical and radiographic evaluation of demineralized bone matrix (grafton) as a bone graft material in the treatment of human periodontal intraosseous defects.
abstract: OBJECTIVE
  The purpose of this clinical trial was to evaluate the efficacy of demineralized bone matrix (DBM) as a bone graft material in the treatment of human intrabony periodontal defects as compared with control defects treated by open flap debridement (OFD) alone.
  
  
  METHODS
  A controlled clinical trial was carried out for a period of 9 months in 11 patients (4 males and 7 females) with an age group of 25-50 years, contributing to a total of 30 defects. The selected defects were then randomly divided in to experimental sites (OFD + DBM) and control sites (OFD alone). Probing depth, clinical attachment levels and position of the gingival margin were recorded at baseline 3, 6 and 9 months post-operatively. Standardized radiographs (parallel technique) were also documented at these recall intervals.
  
  
  RESULTS
  On completion of 9 months, the mean percentage of probing depth reduction achieved in the experimental sites and control sites was 61.70%, 23.86% respectively. The mean percentage of clinical attachment level gain was 61.34% and 19.37% in the experimental and control sites respectively. In the experimental sites recession was observed to a lesser extent.
  
  
  CONCLUSIONS
  The use of DBM was more effective than OFD in improving clinical parameters and radiographic bone fill as shown in the present study. However, there is a need for further long term studies.
authors.affiliation: Department of Periodontics, M.S. Ramaiah Dental College and Hospital, MSRIT Post, MSR Nagar, Mathikere, Bangalore, Karnataka, India.
authors.lastname: Mahantesha
authors.forename: K S
authors.initials: KS
authors.lastname: Shobha
authors.forename: R
authors.initials: R
authors.lastname: Mani
authors.forename: Amritha
authors.initials: A
authors.lastname: Deshpande
authors.forename: Hema
authors.initials: H
authors.lastname: Seshan
authors.forename: K
authors.initials: K
authors.lastname: Kranti
keywords: Allografts; demineralized bone matrix; osteoinduction; regeneration