title: Relative contribution of cognitive and physical disability components to quality of life in MS.
abstract: BACKGROUND
  Information on the relative influence of cognitive and physical impairment on the quality of life in multiple sclerosis is currently limited and no scientific consensus has been reached yet.
  
  
  OBJECTIVE
  For this reason, we wanted to examine the relative contribution of cognitive and physical impairment measures comprised in the MSFC test on quality of life in MS.
  
  
  METHODS
  In the National MS Center Melsbroek, patients regularly undergo MSFC and EQ5D measurements. We investigated the correlations between the EQ5D, EQVAS and the MSFC and EDSS scores by the use of ANOVA and multilinear models.
  
  
  RESULTS
  We found a significant correlation between the EQVAS score and cognition in a univariate model. When including EDSS score and MSFC outcomes into the model, cognition was, however, excluded based on the Akaike Information Criterion. Cognition was, on the other hand, a significant predictor for the "Usual Activities" question of the EQ5D.
  
  
  CONCLUSIONS
  Although cognitive performance as measured on the PASAT-3s does not correlate with a patient's perceived quality of life in a multivariate model, it remains an important predictor for the patient's usual activities.
authors.affiliation: UZ Jette, Center for Neurosciences, Laarbeeklaan 101, 1090, Brussels, Belgium; Faculté de Psychologie et des Sciences de l'Education, Place du parc 20, 7000, Mons, Belgium. Electronic address: Jeroen.Van.Schependom@vub.ac.be.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Van Schependom
authors.affiliation: UZ Jette, Center for Neurosciences, Laarbeeklaan 101, 1090, Brussels, Belgium; National MS Center Melsbroek, Vanheylenstraat 16, 1820, Melsbroek, Belgium. Electronic address: Marie.Dhooghe@mscenter.be.
authors.forename: Marie B
authors.initials: MB
authors.lastname: D'hooghe
authors.affiliation: Faculté de Psychologie et des Sciences de l'Education, Place du parc 20, 7000, Mons, Belgium. Electronic address: Melanie.DeSchepper@umons.ac.be.
authors.forename: Mélanie
authors.initials: M
authors.lastname: De Schepper
authors.affiliation: National MS Center Melsbroek, Vanheylenstraat 16, 1820, Melsbroek, Belgium. Electronic address: Krista.Cleynhens@mscenter.be.
authors.forename: Krista
authors.initials: K
authors.lastname: Cleynhens
authors.affiliation: National MS Center Melsbroek, Vanheylenstraat 16, 1820, Melsbroek, Belgium. Electronic address: Mieke.Dhooge@mscenter.be.
authors.forename: Mieke
authors.initials: M
authors.lastname: D'hooge
authors.affiliation: Faculté de Psychologie et des Sciences de l'Education, Place du parc 20, 7000, Mons, Belgium. Electronic address: Marie-Claire.Haelewyck@umons.ac.be.
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Haelewyck
authors.affiliation: UZ Jette, Center for Neurosciences, Laarbeeklaan 101, 1090, Brussels, Belgium. Electronic address: Jacques.DeKeyser@uzbrussel.be.
authors.forename: Jacques
authors.initials: J
authors.lastname: De Keyser
authors.affiliation: UZ Jette, Center for Neurosciences, Laarbeeklaan 101, 1090, Brussels, Belgium; National MS Center Melsbroek, Vanheylenstraat 16, 1820, Melsbroek, Belgium; Faculté de Psychologie et des Sciences de l'Education, Place du parc 20, 7000, Mons, Belgium. Electronic address: Guy.Nagels@vub.ac.be.
authors.forename: Guy
authors.initials: G
authors.lastname: Nagels
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D004185:Disability Evaluation; D006233:Persons with Disabilities / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012648:Self Care / Q000379:methods / Q000523:psychology / Q000592:standards; D011795:Surveys and Questionnaires / Q000592:standards; D055815:Young Adult
keywords: Cognitive impairment; EQ5D; MSFC; Multiple sclerosis; Physical impairment; Quality of life