title: Clinical neurogenetics: behavioral management of inherited neurodegenerative disease.
abstract: Psychiatric symptoms often manifest years before overt neurologic signs in patients with inherited neurodegenerative disease. The most frequently cited example of this phenomenon is the early onset of personality changes in "presymptomatic" Huntington patients. In some cases the changes in mood and cognition are even more debilitating than their neurologic symptoms. The goal of this article is to provide the neurologist with a concise primer that can be applied in a busy clinic or private practice.
authors.affiliation: Department of Psychiatry, Center for Neurobehavioral Genetics, Semel Institute, University of California Los Angeles School of Medicine, 695 Charles Young Drive South, Gonda Room 2309, Los Angeles, CA 90024-1759, USA. Electronic address: ewexler@ucla.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Wexler
mesh_terms: D001526:Behavioral Symptoms / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000523:psychology*
keywords: Aggression; Bipolar; Impulse-control disorder; Major depression; Psychosis