title: Aspergillus tubingenesis endophthalmitis after cataract surgery with implantation of preloaded intraocular lens.
abstract: Abstract An 88-year-old man underwent uneventful phacoemulsification and aspiration with an implantation of a preloaded acrylic intraocular lens. Six months later, he developed endophthalmitis with negative aqueous cultures, and the inflammation was refractory to conventional antibacterial therapies. He was treated successfully with vitrectomy and removal of the IOL and the entire lens capsule. A combination of intravitreal voriconazole and systemic micafungin were prescribed, and the inflammation was resolved. As best we know, this is the first case of Aspergillus tubingenesis endophthalmitis that followed the implantation of a preloaded intraocular lens.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine , Gifu , Japan .
authors.forename: Satoko
authors.initials: S
authors.lastname: Kokuzawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Suemori
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
mesh_terms: D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D001230:Aspergillus / Q000302:isolation & purification*; D020878:Device Removal; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000627:therapeutic use; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D058449:Intravitreal Injections; D019654:Lens Implantation, Intraocular; D055666:Lipopeptides / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D018918:Phacoemulsification; D011183:Postoperative Complications; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D014792:Visual Acuity; D014821:Vitrectomy; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D000077551:Micafungin
keywords: Aspergillus tubingenesis; endophthalmitis; micafungin; preloaded intraocular lens; voriconazole