title: The relation between total joint arthroplasty and risk for serious cardiovascular events in patients with moderate-severe osteoarthritis: propensity score matched landmark analysis.
abstract: OBJECTIVE
  To examine whether total joint arthroplasty of the hip and knee reduces the risk for serious cardiovascular events in patients with moderate-severe osteoarthritis.
  
  
  METHODS
  Propensity score matched landmark analysis.
  
  
  METHODS
  Ontario, Canada.
  
  
  METHODS
  2200 adults with hip or knee osteoarthritis aged 55 or more at recruitment (1996-98) and followed prospectively until death or 2011.
  
  
  METHODS
  Rates of serious cardiovascular events for those who received a primary total joint arthroplasty compared with those did not within an exposure period of three years after baseline assessment.
  
  
  RESULTS
  The propensity score matched cohort consisted of 153 matched pairs of participants with moderate-severe arthritis. Over a median follow-up period of seven years after the landmark date (start of the study), matched participants who underwent a total joint arthroplasty during the exposure period were significantly less likely than those who did not to experience a cardiovascular event (hazards ratio 0.56, 95% confidence interval 0.43 to 0.74, P<0.001). Within seven years of the exposure period the absolute risk reduction was 12.4% (95% confidence interval 1.7% to 23.1%) and number needed to treat was 8 (95% confidence interval 4 to 57 patients).
  
  
  CONCLUSIONS
  Using a propensity matched landmark analysis in a population cohort with advanced hip or knee osteoarthritis, this study found a cardioprotective benefit of primary elective total joint arthroplasty.
authors.affiliation: Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Canada.
authors.forename: Bheeshma
authors.initials: B
authors.lastname: Ravi
authors.forename: Ruth
authors.initials: R
authors.lastname: Croxford
authors.forename: Peter C
authors.initials: PC
authors.lastname: Austin
authors.forename: Lorraine
authors.initials: L
authors.lastname: Lipscombe
authors.forename: Arlene S
authors.initials: AS
authors.lastname: Bierman
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Harvey
authors.forename: Gillian A
authors.initials: GA
authors.lastname: Hawker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D015207:Osteoarthritis, Hip / Q000601:surgery*; D020370:Osteoarthritis, Knee / Q000601:surgery*; D057216:Propensity Score; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome