title: MicroRNA associated with dyslipidemia and coronary disease in humans.
abstract: MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of lipoprotein metabolism in humans and to discuss relevant methodological and study design considerations. We highlight the potential roles for microRNA in gene-environment interactions.
authors.affiliation: Department of Physiological Nursing, School of Nursing, University of California, San Francisco, California; and.
authors.forename: Elena
authors.initials: E
authors.lastname: Flowers
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Aouizerat
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D003324:Coronary Artery Disease / Q000235:genetics*; D050171:Dyslipidemias / Q000235:genetics*; D059647:Gene-Environment Interaction; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D044382:Population Groups
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: lipids; microRNA