title: Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis.
abstract: Monoamine oxidase (MAO) inhibitors are generally used in the treatment of depressive disorders and some neurodegenerative illnesses, such as Parkinson's disease and Alzheimer's disease. The aim of this preliminary study was to investigate the MAO [MAO (E.C.1.4.3.4)] inhibiting effect of various apitherapeutic products, such as chestnut honey, pollen and propolis. Extracts' MAO inhibition was measured using peroxidase-linked spectrophotometric assay in enzyme isolated from rat liver microsomes, and the values are expressed as the inhibition concentration (IC50) causing 50% inhibition of MAO. The antioxidant activity of the bee products was also determined in terms of total phenolic content (TPC) and ferric reducing/antioxidant power in aquatic extracts. All samples exhibited substantial inhibition of MAO, propolis having the highest. Inhibition was related to samples' TPCs and antioxidant capacities. These results show that bee products possess a sedative effect and may be effective in protecting humans against depression and similar diseases.
authors.affiliation: Maçka Vocational High School, Karadeniz Technical University , Trabzon , Turkey and.
authors.forename: O
authors.initials: O
authors.lastname: Yildiz
authors.forename: F
authors.initials: F
authors.lastname: Karahalil
authors.forename: Z
authors.initials: Z
authors.lastname: Can
authors.forename: H
authors.initials: H
authors.lastname: Sahin
authors.forename: S
authors.initials: S
authors.lastname: Kolayli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D029962:Fagaceae / Q000737:chemistry*; D006722:Honey; D008862:Microsomes, Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry; D011429:Propolis / Q000737:chemistry; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D008996:Monoamine Oxidase Inhibitors; D010936:Plant Extracts; D011429:Propolis; D008995:Monoamine Oxidase
keywords: Honey; monoamine oxidase; pollen; propolis; spectrophotometric peroxidase linked assay