title: Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
abstract: The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.
authors.affiliation: Department of Pharmacology; University of Colorado School of Medicine; Aurora, CO USA.
authors.forename: Brianna J
authors.initials: BJ
authors.lastname: Klein
authors.affiliation: Laval University Cancer Research Center; Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Lalonde
authors.affiliation: Laval University Cancer Research Center; Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Côté
authors.affiliation: Rosalind and Morris Goodman Cancer Research Center; Departments of Medicine, Biochemistry, and Anatomy & Cell Biology; McGill University; Montréal, QC Canada.
authors.forename: Xiang-Jiao
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Department of Pharmacology; University of Colorado School of Medicine; Aurora, CO USA.
authors.forename: Tatiana G
authors.initials: TG
authors.lastname: Kutateladze
mesh_terms: D000107:Acetylation; D000818:Animals; D044127:Epigenesis, Genetic; D051548:Histone Acetyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D055503:Protein Multimerization; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D009687:Nuclear Proteins; D021122:Protein Subunits; D051548:Histone Acetyltransferases; C108712:KAT6A protein, human; C487137:KAT6B protein, human
keywords: BRPF; ING5; KAT6A; KAT6B; MORF; MOZ; PHD; acetylation; histone; reader