title: The pathway of miRNA maturation.
abstract: MicroRNAs (miRNAs) are a novel class of 17-23 nucleotide short, nonprotein-coding RNA molecules which have emerged to be key players in posttranscriptional gene regulation. In this chapter we give an in-depth review of the classic, canonical mammalian miRNA maturation pathway and discuss new, noncanonical alternatives such as the mirtron pathway which were recently described.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Sand
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism*; D059367:RNA Cleavage; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D043244:Ribonuclease III