title: Maternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy.
abstract: We examined the relationship between maternal depressive symptoms in late pregnancy and Epstein-Barr virus reactivation before delivery. In this prospective observational study, prevalence of Epstein-Barr virus reactivation within one week before delivery was compared between 163 pregnant women with depressive symptoms at 33 to 34 weeks of gestation and a computer-generated control group of 163 pregnant healthy women without depressive symptoms. Depressive symptoms at 33 to 34 weeks of gestation were significantly related to the prevalence of Epstein-Barr virus reactivation before delivery after adjustment for potential confounders (adjusted OR = 2.74, 95%CI: 1.23-6.08). Compared to that in the control group, the prevalence of Epstein-Barr virus reactivation was higher in women with depressive symptoms accompanied by higher negative coping (24.2% compared with 7.9%; adjusted OR = 3.67, 95%CI: 1.47-9.16). Maternal depressive symptoms in late pregnancy are associated with Epstein-Barr virus reactivation, and this association could be moderated by maternal coping style.
authors.affiliation: 1] Department of Maternal and Child Health, School of Public Health, Anhui Medical University, Hefei, China [2].
authors.forename: Peng
authors.initials: P
authors.lastname: Zhu
authors.forename: Yu-Jiang
authors.initials: YJ
authors.lastname: Chen
authors.forename: Jia-Hu
authors.initials: JH
authors.lastname: Hao
authors.forename: Jin-Fang
authors.initials: JF
authors.lastname: Ge
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Tao
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Jiang
authors.forename: Fang-Biao
authors.initials: FB
authors.lastname: Tao
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D003863:Depression / Q000453:epidemiology / Q000209:etiology*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D004854:Herpesvirus 4, Human / Q000145:classification / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011263:Pregnancy Trimester, Third; D014775:Virus Activation; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G