title: The therapeutic effects of human adipose-derived stem cells in Alzheimer's disease mouse models.
abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.
authors.affiliation: Department of Pharmacology, College of Medicine, Gachon University, Incheon, Korea.
authors.forename: Keun-A
authors.initials: KA
authors.lastname: Chang
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yuyoung
authors.initials: Y
authors.lastname: Joo
authors.forename: Sungji
authors.initials: S
authors.lastname: Ha
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D000544:Alzheimer Disease / Q000628:therapy*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells; D051379:Mice; D039904:Pluripotent Stem Cells / Q000637:transplantation