title: Predictors of first recurrence of Clostridium difficile infections in children.
abstract: Little is known regarding the risk of recurrence of Clostridium difficile infection (CDI) in children. In a 9-year cohort, 12% of hospitalized children with CDI had recurrent disease. Receipt of concomitant antibiotics and community-associated CDI were independently associated with recurrent disease in children hospitalized with CDI. Antibiotics administered for reasons other than treatment of CDI should be discontinued whenever possible.
authors.affiliation: From the *Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine; †Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health; and ‡Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Sarah
authors.initials: S
authors.lastname: Tschudin-Sutter
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Milstone
authors.forename: Trish M
authors.initials: TM
authors.lastname: Perl
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000188:drug therapy / Q000382:microbiology*; D003967:Diarrhea / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents