title: Life-threatening haematemesis associated with clozapine: a case report and literature review.
abstract: Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.
authors.affiliation: Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria.
authors.forename: Kazeem Olaide
authors.initials: KO
authors.lastname: Adebayo
authors.forename: Nurudeen
authors.initials: N
authors.lastname: Ibrahim
authors.forename: Temilola
authors.initials: T
authors.lastname: Mosanya
authors.forename: Benjamin
authors.initials: B
authors.lastname: Eegunranti
authors.forename: Babatunde
authors.initials: B
authors.lastname: Suleiman
authors.forename: Akeem
authors.initials: A
authors.lastname: Ayankunle
keywords: clozapine; haematemesis; schizophrenia