title: LOX-1: a male hormone-regulated scavenger receptor for atherosclerosis.
abstract: Lectin-like oxidized LDL receptor-1 (LOX-1) is a unique scavenger receptor that mediates the binding and uptake of oxidized LDL (ox-LDL) by vascular cells during the development of atherosclerosis. Exposure to ox-LDL induces LOX-1 expression and LOX-1-dependent biological activities, such as activation of NF-κB, a nuclear factor important for signal transduction in inflammation. Accumulating evidence indicates that male hormones may regulate expression of LOX-1 and NF-κB as well as atherogenesis. Deficiency or low levels of the male hormone testosterone promote LOX-1 expression and NF-κB activation, while testosterone replacement therapy reduces the expression of LOX-1 and the activation of NF-κB, thereby protecting the arterial wall against atherogenesis.
authors.affiliation: The Center of Cardiovascular Biology and Atherosclerosis Research, University of Texas Medical School at Houston, Houston, TX 77030, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Geng
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D051127:Scavenger Receptors, Class E / Q000378:metabolism*; D015398:Signal Transduction; D013739:Testosterone / Q000008:administration & dosage* / Q000172:deficiency / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D016328:NF-kappa B; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein; D013739:Testosterone
keywords: Atherosclerosis; Castration; Inflammation; LOX-1; Testosterone