title: The mitochondrial DNA of the yeast Hansenula petersonii: genome organization and mosaic genes.
abstract: The mitochondrial genomes of yeasts are circular DNA molecules that vary greatly in size in different species. The mitochondrial DNA of the yeast H. petersonii is about 42 kbp in length, about one half the size of the corresponding genome in S. cerevisiae. Sequences homologous to protein-encoding genes from S. cerevisiae have been identified and localized on this genome by hybridization with DNA from petite mutants. The comparison between the mitochondrial genomes of H. petersonii and S. cerevisiae showed differences in the overall genome organization, but both include genes with mosaic organization. In fact, sequences homologous to the first intron of the S. cerevisiae cob short gene are found in (or adjacent to) the cob and cox1 genes present in the genome of H. petersonii. Moreover, an intron homologous to that present in the 21S rRNA gene of S. cerevisiae seems to have been conserved in the large ribosomal RNA gene of H. petersonii, in a similar position.
authors.affiliation: Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Roma, La Sapienza, Piazzale Aldo Moro, I-00100, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Falcone