title: Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells.
abstract: We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Beijing, 100124, P.R. China. shengwang@bjut.edu.cn.
authors.forename: Minjun
authors.initials: M
authors.lastname: Cao
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Deng
authors.forename: Shishuai
authors.initials: S
authors.lastname: Su
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Xiao
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Fu
authors.forename: Burton B
authors.initials: BB
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Wang
authors.initials: W
authors.lastname: Sheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D015972:Gene Expression Regulation, Neoplastic; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D058612:Nanodiamonds / Q000737:chemistry* / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011479:Protamines / Q000737:chemistry* / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000008:administration & dosage
chemical_list: D004337:Drug Carriers; C546703:MIRN203 microRNA, human; D035683:MicroRNAs; D058612:Nanodiamonds; D011479:Protamines; D034741:RNA, Small Interfering