title: Serum lipid levels are associated with the prevalence but not with the disease progression of multiple system atrophy in a Chinese population.
abstract: OBJECTIVE
  Alpha-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by lipids. This study aims to validate the correlation between lipid levels and the prevalence of MSA as well as its progression.
  
  
  METHODS
  A total of 234 patients with probable MSA and 240 age- and gender-matched healthy controls were included in this study. Lipid contents, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG), were evaluated. The unified MSA rating scale (UMSARS) was used to assess the severity of MSA.
  
  
  RESULTS
  Lipid levels in MSA patients were significantly lower than those in healthy controls. Patients with MSA-C were significantly younger, had higher body mass indices (BMIs), higher UMSARS scores, and lower HDL-C contents compared with MSA-P patients. Subjects with the lowest quartiles and the second quartiles of total cholesterol, LDL-C, and HDL-C had high prevalence of MSA compared with subjects with the highest quartiles. No correlation was found between the mean rate of annualized changes and serum levels of lipids as well as other independent factors, such as age, BMI, gender, subtypes (C-type or P-type), and disease duration at the initial visit, in 107 followed-up MSA patients.
  
  
  CONCLUSIONS
  Low levels of total cholesterol, LDL-C, HDL-C, and TG increased the prevalence of MSA in a Chinese population. Patients with MSA-C showed significantly lower levels of HDL-C than MSA-P patients. However, lipids did not deteriorate or improve the progression of MSA.
authors.forename: Bei
authors.initials: B
authors.lastname: Cao
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Guo
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Wei
authors.forename: Bi
authors.initials: B
authors.lastname: Zhao
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Shang
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000097:blood* / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D012720:Severity of Illness Index; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Disease progression; Multiple system atrophy,; Prevalence,; Serum lipid,