title: Hsa-miR-132 regulates apoptosis in non-small cell lung cancer independent of acetylcholinesterase.
abstract: MiR-132 is enriched in the central nerve system and is thought to be involved in neuronal development, maturation and function, and to be associated with several neurological disorders including Alzheimer's disease. In addition to its documented neuronal functions, an emerging role for miR-132 in tumorigenesis has been suggested. Recently, hsa-miR-132 was shown to be modulated in different tumor types. However, its role in non-small cell lung cancer (NSCLC) remains unclear. Here, we show that hsa-miR-132 can initiate apoptosis in NSCLC cells to dramatically attenuate tumor formation in nude mice independent of its effect on the proliferation/apoptosis-associated gene, acetylcholinesterase (AChE). Interestingly, hsa-miR-132 has no pro-apoptotic effect in normal pulmonary trachea epithelium. Taken together, these results suggest that hsa-miR-132 represses NSCLC growth by inducing apoptosis independent of AChE.
authors.affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Xuejin
authors.initials: X
authors.lastname: Zhang
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Ye
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Xi
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: C547077:MIRN132 microRNA, human; D035683:MicroRNAs; D000110:Acetylcholinesterase