title: Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome.
abstract: Opsoclonus-myoclonus ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome of childhood, associated with occult neuroblastoma in 20%-50% of all cases. OMA is the initial presentation of neuroblastoma in 1%-3% of children. Conventional radiological imaging approaches include chest radiography and abdominal computed tomography (CT). Nuclear medicine techniques, in form of (123)I/(131)I-metaiodobenzylguanidine (MIBG) scintigraphy have been incorporated in various diagnostic algorithms for evaluation of OMA. We describe use of somatostatin receptor PET/CT with (68)Gallium- DOTA-DPhe(1), Tyr(3)-octreotate (DOTATATE) in diagnosis of neuroblastoma in two cases of OMA.
authors.affiliation: Department of Nuclear Medicine and PET-CT, Jaslok Hospital & Research Centre, Worli, Mumbai, Maharashtra, India.
authors.forename: Prathamesh
authors.initials: P
authors.lastname: Joshi
authors.forename: Vikram
authors.initials: V
authors.lastname: Lele
keywords: 68Gallium DOTATATE; Occult neuroblastoma; opsoclonus-myoclonus ataxia; somatostatin receptor PET/CT