title: Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection.
abstract: Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery efficiency and ultrafast sensor response, as compared to conventional fluidic systems. 70 nm sized virus like analyte solution is used to experimentally demonstrate the system performance improvements. Sensor response time is reduced by one order of magnitude as compared to the conventional methods. A seven orders of magnitude dynamic concentration range from 10(3) to 10(9) particles mL(-1) is quantified, corresponding to a concentration window relevant to clinical diagnosis and drug screening. Our non-destructive detection system, by enabling efficient analyte delivery, fast sensing response and minimal sample volume, opens up opportunities for sensitive, rapid and real-time virus detection in infectious disease control and point-of-care applications.
authors.affiliation: Electrical and Computer Engineering Department, Boston University, Boston, MA, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Betty C
authors.initials: BC
authors.lastname: Galarreta
authors.forename: Arif E
authors.initials: AE
authors.lastname: Cetin
authors.forename: Hatice
authors.initials: H
authors.lastname: Altug
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D057230:Limit of Detection; D036103:Nanotechnology / Q000295:instrumentation; D055096:Optical Devices; D019095:Point-of-Care Systems; D012212:Rheology / Q000295:instrumentation*; D013997:Time Factors; D014780:Viruses / Q000302:isolation & purification*