title: Non-adherence in difficult asthma and advances in detection.
abstract: Non-adherence to anti-inflammatory therapies is common in patients referred for specialist assessment at difficult-to-treat asthma services. In the difficult asthma setting, non-adherence to treatment is associated with poor baseline asthma control, increased frequency of exacerbations and asthma-related hospitalizations, as well as increased risk of death. Here, we present a review of the current literature surrounding the prevalence and risks of non-adherence in difficult asthma and we report on current methods of measuring treatment adherence and advances in the detection of non-adherence. We will also explore methods by which non-adherence in difficult asthma can be addressed.
authors.affiliation: Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast, UK.
authors.forename: John T
authors.initials: JT
authors.lastname: Lindsay
authors.forename: Liam G
authors.initials: LG
authors.lastname: Heaney
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D057566:Self Report; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D018927:Anti-Asthmatic Agents