title: Association of cytokine/costimulatory molecule polymorphism and allograft rejection: a comparative review.
abstract: One reason for genetic variations among human individuals is SNP which may confer diverse disease susceptibility or resistance in a population. Genetic variations in a key immunoregulatory agent can manifest various immunological responses, such as graft rejection. In fact, the outcome of organ transplantation can be impacted by several genetic causes including polymorphisms in genes encoding cytokines and costimulatory molecules in the donor or recipient. Thus, it can be helpful to contemplate the SNPs relating to these immunological determinants in order to achieve an improved transplantation therapy.
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Karimi
authors.forename: Padideh
authors.initials: P
authors.lastname: Ebadi
authors.forename: Ali A
authors.initials: AA
authors.lastname: Pourfathollah
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000818:Animals; D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D020239:Receptor Cross-Talk; D015398:Signal Transduction / Q000235:genetics; D014181:Transplantation Immunology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines