title: Malignant peripheral nerve sheath tumour in the nasopharynx of a cow.
abstract: This case describes the findings in a Swiss Braunvieh cow with a malignant peripheral nerve sheath tumour (MPNST) in the nasopharynx. The major clinical signs were mixed dyspnoea with inspiratory and expiratory noises. Radiographic views of the head revealed an irregular mass with soft-tissue density in the nasopharynx originating from the dorsal pharynx and occupying and restricting the pharyngeal cavity. Endoscopic examination showed a lobulated mass obstructing almost the entire lumen of the aboral nasal passages and nasopharynx. Postmortem examination revealed a lobulated mass in the choanae with a broad attachment to the dorsal pharynx and histologically a soft tissue sarcoma with tumour cells positive for the S-100 and p75NTR (neurotrophin receptor) proteins and negative for CNPase. Electron microscopic examination showed few structures that indicated that the tumour originated from Schwann cells.
authors.affiliation: Institute of Veterinary Pathology, University of Zurich.
authors.forename: T
authors.initials: T
authors.lastname: Sydler
authors.forename: M
authors.initials: M
authors.lastname: Lesser
authors.forename: N
authors.initials: N
authors.lastname: Waldern
authors.forename: M
authors.initials: M
authors.lastname: Dennler
authors.forename: B
authors.initials: B
authors.lastname: Bode-Lesniewska
authors.forename: A
authors.initials: A
authors.lastname: Pospischil
authors.forename: U
authors.initials: U
authors.lastname: Braun
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D011859:Radiography
keywords: Immunhistochemie; MPNST; Nasopharynx; Neoplasie; Rind; bovine; immunohistochemistry; nasopharynx; tumour