title: Importance of systemic mediastinal lymphadenectomy in exact staging of bronchogenic carcinoma.
abstract: BACKGROUND
  Constituent part of radical lung resection for lung cancer is a dissection of mediastinal lymph nodes. Lymphadenectomy is a standard procedure in an assessment of clinical stage of the disease. The aim of the study was to map metastasizing of bronchogenic non-small cell lung carcinoma into homolateral mediastinal lymph nodes and to assess the importance of mediastinal lymphadenectomy for exact staging and survival.
  
  
  METHODS
  Study of 31patients with lung resection and systematic mediastinal lymphadenectomy operated from August 2004 to January 2007, with pre-operative stage Ia to IIb (TNM classification) - according to CT without mediastinal lymph nodes invasion and with positive histological finding after systematic mediastinal lymphadenectomy.
  
  
  RESULTS
  Tumors in right upper lobe metastasized in 45.5 % into group 1 nodes (stages N1-N4) and group 3 nodes (stages N7) and in 9 % into group 4 nodes (stages N8-N9). Tumors of the right middle lobe metastasized in 100 % into group 3 nodes (stage N7).Tumors of the right lower lobe metastasized in 87.5 % into group 3 nodes (N7) and in 12.5 % into group 4 nodes (stages N8-N9). Tumors of the left upper lobe metastasized in 9.0 % in group 1 nodes (stages N1-N4), in 82 % into group 2 nodes (stages N5-N6) and in 9.0 % were found skip metastases into group 4 nodes (stages N8-N9). Tumors of the left lower lobe metastasized in 26.7 % in group 4 nodes, 46.6 % into group 3 nodes, in 20,0 % into group 2 nodes and in 6,7 % into group 1 nodes.
  
  
  CONCLUSIONS
  Systematic mediastinal lymphadenectomy is crucial for determining the stage of the disease according to the TNM classification. Systematic lymphadenectomy is essential for the diagnosis of stage IIIa disease and setting of additional therapy that prolongs survival (Ref. 17).
authors.forename: V
authors.initials: V
authors.lastname: Hytych
authors.forename: A
authors.initials: A
authors.lastname: Taskova
authors.forename: P
authors.initials: P
authors.lastname: Horazdovsky
authors.forename: Z
authors.initials: Z
authors.lastname: Konopa
authors.forename: R
authors.initials: R
authors.lastname: Demes
authors.forename: J
authors.initials: J
authors.lastname: Cermak
authors.forename: A
authors.initials: A
authors.lastname: Vrabcova
authors.forename: P
authors.initials: P
authors.lastname: Hoferka
authors.forename: R
authors.initials: R
authors.lastname: Pohnan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002283:Carcinoma, Bronchogenic / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D008197:Lymph Node Excision / Q000379:methods*; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011446:Prospective Studies
keywords: systematic lymphadenectomy, bronchogenic carcinoma, additional therapy, lung cancer.