title: Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics.
abstract: A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) imaging and photothermal therapy (PTT). The synthesized gold nanostars were tagged with a SERS reporter and linked with an MRI contrast agent Gd(3+). In vitro experiments demonstrated the developed QMT nanoprobe to be a potential theranostic agent for future biomedical applications.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC, USA. tuan.vodinh@duke.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chang
authors.forename: Hsiangkuo
authors.initials: H
authors.lastname: Yuan
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Fales
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000627:therapeutic use; D006801:Humans; D049449:Luminescence; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D053768:Metal Nanoparticles / Q000627:therapeutic use; D015336:Molecular Probe Techniques / Q000295:instrumentation; D064847:Multimodal Imaging / Q000295:instrumentation / Q000379:methods*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods*; D011379:Prognosis; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods
chemical_list: D006046:Gold