title: Photodegradation of β-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts.
abstract: Herein we report that POMs can not only inhibit Aβ aggregation but also photodegrade Aβ, especially the oligomers, showing enhanced inhibition effects.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Can
authors.initials: C
authors.lastname: Xu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Enbo
authors.initials: E
authors.lastname: Wang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D016716:PC12 Cells; D010772:Phosphotungstic Acid / Q000737:chemistry; D010782:Photolysis; D017433:Protein Structure, Secondary; D051381:Rats; D017973:Tungsten Compounds / Q000737:chemistry*; D014466:Ultraviolet Rays; D000099294:Polyoxometalates
chemical_list: D000682:Amyloid; D010772:Phosphotungstic Acid; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates