title: [Glycoproteins of mucus of gastric and duodenal wall surface during ulcerogenesis and the impact of fenugreek].
abstract: The comparative evaluation of qualitative and quantitative composition of glycoproteins of gastric and duodenal wall surface layer of protective mucus in the normal, at the modeling of ulcers in rats and at the introduction to animals with ulcerative lesions of fenugreek extract carried out. It was shown in control (normally) the general level of glycosylation of glycoproteins gastric mucus is 1.7 times more than the duodenum. Under acute stress model ulceration in the stomach mucus decrease in hexosamine (1.4 times), galactose (2.2 times), fucose (1.3-fold) and an increase in NANA (3.6 times) observed. Under cysteamine model ulceration in duodenal mucus increase galactose (2.7 times), NANA (2.4 times), fucose (1.8-fold) but significant decrease in the amount of hexosamines 3 times compared to the control occurred. It was proved the protective effect of fenugreek extract to the wall surface mucus of the stomach and duodenum mucosa under conditions modeling ulceration in rats.
authors.forename: T D
authors.initials: TD
authors.lastname: Khil'ko
authors.forename: I V
authors.initials: IV
authors.lastname: Iakubtsova
authors.forename: T D
authors.initials: TD
authors.lastname: Preobrazhens'ka
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
mesh_terms: D000818:Animals; D003543:Cysteamine / Q000009:adverse effects; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005643:Fucose / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D006595:Hexosamines / Q000378:metabolism; D007103:Immobilization; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D029910:Trigonella
chemical_list: D006023:Glycoproteins; D006595:Hexosamines; D010936:Plant Extracts; C047874:gastric mucus glycoproteins; D005643:Fucose; D003543:Cysteamine; C056164:fenugreek seed meal; D019158:N-Acetylneuraminic Acid; D005690:Galactose