title: Personalizing and targeting therapy for COPD: the role of molecular and clinical biomarkers.
abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These include cigarette smoking, environmental and occupational pollutants, respiratory infections and comorbidities. As the clinical phenotypes of COPD are so variable, it has been difficult to devise an individualized treatment plan for patients with this complex chronic disease. This review will highlight how potential clinical, inflammatory, genomic and epigenomic biomarkers for COPD could be used to personalize treatment, leading to improved disease management and prevention for our patients.
authors.affiliation: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia.
authors.forename: Felicia
authors.initials: F
authors.lastname: Goh
authors.forename: Janet G
authors.initials: JG
authors.lastname: Shaw
authors.forename: Santiyagu M
authors.initials: SM
authors.lastname: Savarimuthu Francis
authors.forename: Annalicia
authors.initials: A
authors.lastname: Vaughan
authors.forename: Leanne
authors.initials: L
authors.lastname: Morrison
authors.forename: Vandana
authors.initials: V
authors.lastname: Relan
authors.forename: Henry M
authors.initials: HM
authors.lastname: Marshall
authors.forename: Annette G
authors.initials: AG
authors.lastname: Dent
authors.forename: Phoebe E
authors.initials: PE
authors.lastname: O'Hare
authors.forename: Amy
authors.initials: A
authors.lastname: Hsiao
authors.forename: Rayleen V
authors.initials: RV
authors.lastname: Bowman
authors.forename: Kwun M
authors.initials: KM
authors.lastname: Fong
authors.forename: Ian A
authors.initials: IA
authors.lastname: Yang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D019468:Disease Management; D057890:Epigenomics; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends*; D057285:Precision Medicine / Q000639:trends*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000378:metabolism / Q000628:therapy*
chemical_list: D015415:Biomarkers