title: Synthesis of substituted tetrahydrocyclobuta[b]benzofurans by palladium-catalyzed substitution/[2+2] cycloaddition of propargylic carbonates with 2-vinylphenols.
abstract: Radical methods: The title reaction proceeds in the presence of a palladium catalyst to deliver substituted tetrahydrocyclobuta[b]benzofurans in a stereoselective manner. A radical mechanism is discussed.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505 (Japan). yoshi@tokushima-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Shoko
authors.initials: S
authors.lastname: Ohno
authors.forename: Kosuke
authors.initials: K
authors.lastname: Namba
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D002254:Carbonates; D010636:Phenols; D014753:Vinyl Compounds; D010165:Palladium
keywords: cyclizations; heterocycles; palladium; radicals; synthetic methods