title: Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes.
abstract: G protein-coupled receptors constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. Recent advances in crystallization methods have permitted to resolve the molecular structure of several members of the family. This chapter focuses on the impact of these structures in the use of homology modeling techniques for building three-dimensional models of homologous G protein-coupled receptors, higher order oligomers, and their complexes with ligands and signaling proteins.
authors.affiliation: Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Gonzalez
authors.forename: Arnau
authors.initials: A
authors.lastname: Cordomí
authors.forename: Minos
authors.initials: M
authors.lastname: Matsoukas
authors.forename: Julian
authors.initials: J
authors.lastname: Zachmann
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pardo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003460:Crystallization / Q000379:methods; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology; D040681:Structural Homology, Protein
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled