title: Facile preparation of tetrahydro-5H-pyrido[1,2,3-de]-1,4-benzoxazines via reductive cyclization of 2-(8-quinolinyloxy)ethanones and their antioxidant activity.
abstract: Pd/C-catalyzed reductive cyclization of 1-aryl-2-(8-quinolinyloxy)ethanones opens a facile access to the title compounds in good yields. The scope of this reductive cyclization is explored and the antioxidant activities of the products are studied.
authors.affiliation: Department of Chemistry, University of Pune, Ganeshkhind, Pune 411007, India.
authors.forename: Viraj P
authors.initials: VP
authors.lastname: Patil
authors.forename: Vijay L
authors.initials: VL
authors.lastname: Markad
authors.forename: Kisan M
authors.initials: KM
authors.lastname: Kodam
authors.forename: Suresh B
authors.initials: SB
authors.lastname: Waghmode
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000098:Acetophenones; D000975:Antioxidants; D048588:Benzoxazines; D005609:Free Radicals
keywords: Antioxidants; Catalytic hydrogenation; Cyclization; Oxazino-fused tetrahydroquinolines; Reductive amination