title: New diterpenoids from soft coral Sarcophyton ehrenbergi.
abstract: Continuing chemical investigation on the acetone extracts of the soft coral Sarcophyton ehrenbergi collected off the coast of San-hsian-tai, Taitong County, Taiwan led to the isolation of two new diterpenoids, ehrenbergol C and acetyl ehrenberoxide B (1 and 2). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, in vitro tests show that compounds 1 and 2 displayed antiviral activity towards human cytomegalovirus, with EC50 of 20 and 8.0 µg/mL, respectively.
authors.affiliation: Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. yihduh@mail.nsysu.edu.tw.
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.forename: Mu-Keng
authors.initials: MK
authors.lastname: Hsieh
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D013057:Spectrum Analysis / Q000379:methods; D013624:Taiwan
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes