title: Concordance of resistance profiles in households of patients with multidrug-resistant tuberculosis.
abstract: We estimated the proportion of household contacts whose drug-susceptibility test results matched those of the purported source patient with multidrug-resistant tuberculosis. Ninety-nine (88.4%) contacts had isolates resistant to isoniazid and rifampin, and 41 (36.6%) contacts had isolates with results that also matched the purported source for ethambutol, streptomycin, and pyrazinamide.
authors.affiliation: Division of Global Health Equity, Brigham and Women's Hospital.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Parr
authors.forename: Carole D
authors.initials: CD
authors.lastname: Mitnick
authors.forename: Sidney S
authors.initials: SS
authors.lastname: Atwood
authors.forename: Katiuska
authors.initials: K
authors.lastname: Chalco
authors.forename: Jaime
authors.initials: J
authors.lastname: Bayona
authors.forename: Mercedes C
authors.initials: MC
authors.lastname: Becerra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D005191:Family Characteristics; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification*; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: DST; contact; discordant; empirical; presumptive