title: A cytotoxic dimeric furanoheliangolide fromPiptocoma rufescens.
abstract: A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves ofPiptocoma rufescens, collected in the Dominican Republic. Its structure was determined by analysis of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50value of 150 nM, when tested against HT-29 human colon cancer cells.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ren
authors.forename: Francisco
authors.initials: F
authors.lastname: Jiménez
authors.forename: Ricardo
authors.initials: R
authors.lastname: García
authors.forename: Milciades
authors.initials: M
authors.lastname: Mejía
authors.forename: Heebyung
authors.initials: H
authors.lastname: Chai
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Djaja D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
keywords: Cytotoxicity; Furanoheliangolide dimer; Piptocoma rufescens