title: Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation.
abstract: BACKGROUND
  Ayurvedic system of medicine holds a number of drugs that improves the immunity. Āmalaki (Emblica officinalis) is one such drug. Researches with crude extracts of Āmalaki have proven the antioxidant and immunomodulatory activities. But, works on Āmalaki Rasāyana are not found reported.
  
  
  OBJECTIVE
  Considering this, two samples of Āmalaki Rasāyana (AR7 and AR21) were studied to evaluate comparative immunomodulatory activity against the cyclophosphamide immunosuppression in rats.
  
  
  METHODS
  Test drugs were prepared by following classical guidelines. Wistar strain albino rats of either sex were used in the study.
  
  
  METHODS
  For comparison of data from cyclophosphamide control group with remaining cyclophosphamide plus test drug administered groups one way ANOVA with Dunnett's multiple t-test (DMTT) was employed.
  
  
  CONCLUSIONS
  Āmalaki Rasāyana possesses significant immunostimulant activity and moderate cytoprotective activity. AR21 was found to have better activity profile in terms of both immunostimulant as well as cytoprotective activity.
authors.affiliation: Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors.forename: Jignesh
authors.initials: J
authors.lastname: Rajani
authors.forename: B K
authors.initials: BK
authors.lastname: Ashok
authors.lastname: Galib
authors.forename: B J
authors.initials: BJ
authors.lastname: Patgiri
authors.forename: P K
authors.initials: PK
authors.lastname: Prajapati
authors.forename: B
authors.initials: B
authors.lastname: Ravishankar
keywords: Ghrita; Madhu; Rasāyana; cyclophosphamide; humoral immunity; Āmalaki