title: Processing the complexities of transcription.
abstract: Recent studies have revealed unexpected subunit diversity and specificity in the general transcription machinery for orchestrating multicellular differentiation. In this issue of Developmental Cell, Oyama et al. (2013) report a requirement for Taspase 1-dependent TFIIA proteolytic processing in the mouse testis to enable TRF2 targeting to genes regulating spermatogenic differentiation.
authors.affiliation: Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA. Electronic address: richard_freiman@brown.edu.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Freiman
mesh_terms: D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D008297:Male; D013091:Spermatogenesis / Q000502:physiology*; D035341:Telomeric Repeat Binding Protein 2 / Q000378:metabolism*; D035561:Transcription Factor TFIIA / Q000378:metabolism*
chemical_list: C534796:TRF2 protein, mouse; D035341:Telomeric Repeat Binding Protein 2; D035561:Transcription Factor TFIIA; D010450:Endopeptidases; C513958:taspase1, mouse