title: Clinical and radiographic evaluation of regenerative potential of GTR membrane (Biomesh®) along with alloplastic bone graft (Biograft®) in the treatment of periodontal intrabony defects.
abstract: OBJECTIVE
  The primary goal of periodontal therapy is to restore the tooth supporting tissues lost due to periodontal disease. The aim of the present study was to compare the efficacy of combination of GTR membrane and alloplastc bone graft with open flap debridement (OFD) in treatment of periodontal intrabony defects.
  
  
  METHODS
  Twenty paired intrabony defects were surgically treated using split mouth design. The defects were randomly assigned to treatment with OFD, GTR membrane+bone graft (test) or OFD alone (control). The clinical efficacy of two treatment modalities was evaluated at 6 months postoperatively by clinical, radiographical parameters. The measurements included probing pocket depth (PD), clinical attachment level (CAL), gingival recession (GR), bone fill (BF), bone density (BD).
  
  
  RESULTS
  The mean reduction in PD at 0 to 6 months was 3.20±0.82 mm and CAL gain of 3.10±1.51 mm occurred in the GTR membrane+bone graft (test) group; corresponding values for OFD (control) were 2.10±0.63 mm and 1.90±0.57 mm. Similar pattern of improvement was observed when radiographically postoperative evaluation was made. All improvement in different parameters was statistically significant (p<0.01).
  
  
  CONCLUSIONS
  Treatment with a combination of collagen membrane and bone graft led to a significantly more favorable clinical outcome in intrabony defects as compared to open flap debridement alone.
authors.affiliation: Professor, Department of Periodontics, Meghna Institute of Dental Sciences, Mallaram, Andhra Pradesh, India.
authors.forename: James Manohar
authors.initials: JM
authors.lastname: Mopur
authors.forename: T Rama
authors.initials: TR
authors.lastname: Devi
authors.forename: Syed Muhammad
authors.initials: SM
authors.lastname: Ali
authors.forename: T S
authors.initials: TS
authors.lastname: Srinivasa
authors.forename: V
authors.initials: V
authors.lastname: Gopinath
authors.forename: A R Tariq
authors.initials: AR
authors.lastname: Salam
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen; D003646:Debridement / Q000379:methods; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use; D019344:Lactic Acid / Q000737:chemistry; D008567:Membranes, Artificial; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016300:Radiography, Bitewing; D013524:Surgical Flaps / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D006882:Hydroxyapatites; D008567:Membranes, Artificial; C074950:hydroxyapatite-beta tricalcium phosphate; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen