title: Lung cancer screening with low-radiation dose computed tomography after liver transplantation.
abstract: Background The prognosis of non-cutaneous malignancies after liver transplantation is dismal, mainly because most cases are diagnosed at advanced stages. In the last decade, studies have shown the potential role of screening for lung cancer with low-radiation dose computed tomography. Material and Methods Fifty-nine liver transplant recipients with a cumulative dose of smoking greater than 10 pack-years were enrolled in a lung cancer screening program using yearly low-radiation dose computed tomography. Results Lung cancer was diagnosed in 7 patients (11.8%), 5 of which were in stage Ia at diagnosis. Patients with lung cancer were significantly older (median age 66 vs. 58 years), had a higher cumulative history of smoking, and had emphysema more frequently than patients without cancer. Conclusions Screening for lung cancer with low-radiation dose computed tomography in liver transplant recipients results in the diagnosis of lung cancer in early stages.
authors.affiliation: Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Herrero
authors.forename: Gorka
authors.initials: G
authors.lastname: Bastarrika
authors.forename: Delia
authors.initials: D
authors.lastname: D'Avola
authors.forename: Usua
authors.initials: U
authors.lastname: Montes
authors.forename: Jesus
authors.initials: J
authors.lastname: Pueyo
authors.forename: Mercedes
authors.initials: M
authors.lastname: Iñarrairaegui
authors.forename: Fernando
authors.initials: F
authors.lastname: Pardo
authors.forename: Jorge
authors.initials: J
authors.lastname: Quiroga
authors.forename: Javier
authors.initials: J
authors.lastname: Zulueta
mesh_terms: D000328:Adult; D000368:Aged; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012307:Risk Factors; D012907:Smoking