title: Long-term efficacy of latanoprost in primary congenital glaucoma.
abstract: OBJECTIVE
  To investigate the success (glaucoma control) of latanoprost therapy of primary congenital glaucoma (PCG) and factors affecting the long-term outcome.
  
  
  METHODS
  Patients with PCG treated with latanoprost were re-examined. At study visit and from clinical charts, we evaluated: intraocular pressure, length of glaucoma control with latanoprost, need of further medication or glaucoma surgery, systemic and topical side effects. Multivariate analysis was used to test factors related to the final outcome of the treatment.
  
  
  RESULTS
  Eighty-one eyes of 44 patients with PCG, and 42 eyes of 29 patients with previous glaucoma surgery, had received latanoprost therapy. In the first group, a success (glaucoma control by latanoprost therapy) was found in 24 eyes (29.6%), whereas 57 eyes (70.4%) had received surgery (45 eyes (55.6%) in the first year); among the eyes with previous surgery, a success was found in 12 eyes (28.6%), 13 eyes (31%) required an additional therapy, and 17 eyes (40.5%) had received further glaucoma surgery. No patient discontinued the treatment because of side effects. Factors related to the failure of the latanoprost treatment were: the high score of severity of glaucoma (P=0.014) and low age at PCG presentation (P=0.042).
  
  
  CONCLUSIONS
  Long-term treatment with latanoprost is effective in about 30% of the eyes; factors related to failure were severe glaucomatous alterations, and young age at PCG presentation.
authors.affiliation: Eye Clinic, Department of Medical Surgical Specialties, University of Catania, Catania, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Uva
authors.affiliation: Eye Clinic, Department of Medical Surgical Specialties, University of Catania, Catania, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Avitabile
authors.affiliation: Eye Clinic, Department of Medical Surgical Specialties, University of Catania, Catania, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Reibaldi
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, Catania, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bucolo
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Drago
authors.affiliation: Department of Ophthalmology, University of Brescia, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Quaranta
authors.affiliation: Department of Paediatrics, University of Catania, Catania, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Lionetti
authors.affiliation: Eye Clinic, Department of Medical Surgical Specialties, University of Catania, Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Longo
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000151:congenital* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost