title: N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder.
abstract: The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.
authors.affiliation: Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Moreno-Villanueva
authors.forename: J
authors.initials: J
authors.lastname: Morath
authors.forename: V
authors.initials: V
authors.lastname: Vanhooren
authors.forename: T
authors.initials: T
authors.lastname: Elbert
authors.forename: S
authors.initials: S
authors.lastname: Kolassa
authors.forename: C
authors.initials: C
authors.lastname: Libert
authors.forename: A
authors.initials: A
authors.lastname: Bürkle
authors.forename: I-T
authors.initials: IT
authors.lastname: Kolassa
mesh_terms: D000328:Adult; D019588:Aging, Premature / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000097:blood / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
chemical_list: D011134:Polysaccharides