title: Privileged substructure-based diversity-oriented synthesis pathway for diverse pyrimidine-embedded polyheterocycles.
abstract: A new diversity-oriented synthesis pathway for the fabrication of a pyrimidine-embedded polyheterocycles library was developed for potential interactions with diverse biopolymers. Five different pyrimidine-embedded core skeletons were synthesized from ortho-alkynylpyrimidine carbaldehydes by a silver- or iodine-mediated tandem cyclization strategy. The resulting polyheterocycles possess diverse fused ring sizes and positions with potential functionalities for further modification.
authors.affiliation: Department of Chemistry and Department of Biophysics and Chemical Biology/Bio-MAX Institute, Seoul National University , Seoul 151-747, Korea.
authors.forename: Heejun
authors.initials: H
authors.lastname: Kim
authors.forename: Truong Thanh
authors.initials: TT
authors.lastname: Tung
authors.forename: Seung Bum
authors.initials: SB
authors.lastname: Park
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001704:Biopolymers; D006571:Heterocyclic Compounds; D011743:Pyrimidines