title: Assessment of early atherosclerotic findings in patients with nasal polyposis.
abstract: OBJECTIVE
  To investigate early markers of atherosclerosis in patients with nasal polyposis (NP) through measurements of carotid artery intima-media thickness (CIMT), flow-mediated vasodilatation (FMD) of the brachial artery and serum paraoxonase-1 (PON-1) activity.
  
  
  METHODS
  Forty-five patients with NP were included in the study group and 45 healthy individuals in the control group. The diagnosis of patients with NP was predicated on anterior rhinoscopy, endoscopic nasal examination and coronal paranasal sinus computed tomography (CT). Measurements of CIMT and FMD of the brachial artery were performed by high-resolution ultrasonography. Serum PON-1 activity was evaluated by measuring the rate of paraoxon hydrolysis.
  
  
  RESULTS
  Mean CIMT values were found to be increased in the NP group compared to the control group. However, mean FMD % values and serum PON-1 activity were significantly lower in the NP group compared to the control group. Moreover; the endoscopic polyps' scores and paranasal sinus CT scores were positively correlated with CIMT and negatively correlated with FMD % values and PON-1 activity. Disease duration also was positively correlated with CIMT and negatively correlated with FMD % values.
  
  
  CONCLUSIONS
  Impaired FMD, increased CIMT and decreased serum PON-1 activity may be considered to be risk factors for accelerated atherosclerosis in patients with NP who may have subclinical atherosclerosis and be at risk for cardiovascular events in the future.
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT, Turkey. Electronic address: musagit@yahoo.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sagit
authors.affiliation: Kayseri Training and Research Hospital, Department of Cardiology, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Sarli
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT, Turkey.
authors.forename: Sabri
authors.initials: S
authors.lastname: Guler
authors.affiliation: Turgut Ozal University School of Medicine, Department of Biochemistry, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Namuslu
authors.affiliation: Turgut Ozal University School of Medicine, Department of Biochemistry, Turkey.
authors.forename: Huseyin Tugrul
authors.initials: HT
authors.lastname: Celik
authors.affiliation: Kayseri Training and Research Hospital, Department of Cardiology, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Kurtul
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Korkmaz
authors.affiliation: Kayseri Training and Research Hospital, Department of ENT, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Somdas
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000201:enzymology; D001916:Brachial Artery / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications*; D010261:Paraoxon / Q000378:metabolism; D012307:Risk Factors; D014664:Vasodilation / Q000502:physiology*
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D010261:Paraoxon
keywords: Atherosclerosis; Carotid artery intima-media thickness; Flow-mediated vasodilatation; Nasal polyposis; Paraoxonase