title: Prospective comparison of chilled versus room temperature saline irrigation in alcohol-assisted photorefractive keratectomy.
abstract: BACKGROUND
  Chilled saline is commonly used to irrigate the ocular surface after photorefractive keratectomy (PRK) and is often considered by the patients to be uncomfortable. Room temperature (non-chilled) saline may be a safe and less painful alternative.
  
  
  OBJECTIVE
  To compare pain and visual outcomes after irrigating the ocular surface with chilled saline versus room temperature saline in alcohol assisted PRK.
  
  
  METHODS
  In this prospective, single-masked, randomized, contralateral eye study, myopic eyes were treated with PRK. Immediately after laser ablation one eye was irrigated with chilled saline and the other with non-chilled saline. Primary outcomes measured were pain, haze, uncorrected (UCVA) and best-corrected (BCVA) visual acuities, and manifest refraction.
  
  
  RESULTS
  Each group comprised of 40 eyes. There was no significant difference in pain between the groups at any point during five days after surgery. At 6 months the mean UCVA was -0.08 logMAR ± .077 [SD] (20/17) and -0.07 ± .074 logMAR (20/17) in the chilled and non-chilled groups respectively (p =.35). Both groups achieved 95% UCVA of 20/20 or better. The manifest refraction spherical equivalent (MRSE) was -0.05 ± 0.21 D and -0.025 ± 0.27 D respectively (p = .79). There were no lines lost of BCVA and no haze observed. Similar outcomes were observed with regard to pain and vision in both groups.
  
  
  CONCLUSIONS
  The use of room temperature saline irrigation during PRK appears to be safe and effective.
authors.forename: M C
authors.initials: MC
authors.lastname: Neuffer
authors.forename: Y M
authors.initials: YM
authors.lastname: Khalifa
authors.forename: M
authors.initials: M
authors.lastname: Moshirfar
authors.forename: M D
authors.initials: MD
authors.lastname: Miffin
mesh_terms: D000328:Adult; D003315:Cornea / Q000601:surgery*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D010149:Postoperative Pain / Q000517:prevention & control*; D018903:Photorefractive Keratectomy / Q000379:methods*; D011446:Prospective Studies; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000008:administration & dosage*; D013696:Temperature; D007507:Therapeutic Irrigation / Q000379:methods; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D012965:Sodium Chloride