title: The effects of oxytocin on social reward learning in humans.
abstract: It has been hypothesised that the mechanisms modulating social affiliation are regulated by reward circuitry. Oxytocin, previously shown to support affiliative behaviour and the processing of socio-emotional stimuli, is expressed in areas of the brain involved in reward and motivation. However, limited data are available that test if oxytocin is directly involved in reward learning, or whether oxytocin can modulate the effect of emotion on reward learning. In a double-blind, randomised, placebo-controlled, within-group study design, 24 typical male volunteers were administered 24 IU of oxytocin or placebo and subsequently completed an affective reward learning task. Oxytocin selectively reduced performance of learning rewards, but not losses, from happy faces. The mechanism by which oxytocin may be exerting this effect is discussed in terms of whether oxytocin is affecting identity recognition via affecting the salience of happy faces. We conclude that oxytocin detrimentally affects learning rewards from happy faces in certain contexts.
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Clark-Elford
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Pradeep J
authors.initials: PJ
authors.lastname: Nathan
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Auyeung
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Valerie
authors.initials: V
authors.lastname: Voon
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Akeem
authors.initials: A
authors.lastname: Sule
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Müller
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Dudas
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Sahakian
authors.affiliation: Departments of Psychiatry and Psychology, University of Illinois at Chicago, USA.
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Baron-Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005149:Facial Expression; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D010364:Pattern Recognition, Visual / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D012201:Reward; D055815:Young Adult
chemical_list: D010121:Oxytocin