title: Influence of obstructive jaundice on pharmacodynamics of rocuronium.
abstract: BACKGROUND
  Anesthetics are variable in patients with obstructive jaundice. The minimum alveolar concentration awake of desflurane is reduced in patients with obstructive jaundice, while it has no effect on pharmacodynamics and pharmacokinetics of propofol. In this study, we investigated the influence of obstructive jaundice on the pharmacodynamics and blood concentration of rocuronium.
  
  
  METHODS
  Included in this study were 26 control patients and 27 patients with obstructive jaundice. Neuromuscular block of rocuronium was monitored by acceleromyography. Onset time, spontaneous recovery of the height of twitch first (T1) to 25% of the final T1 value (Duration 25%, Dur 25%), recovery index (RI), and spontaneous recovery of train-of-four (TOF) ratios to 70% were measured. The plasma rocuronium concentrations were determined by high performance liquid chromatography using berberine as an internal standard.
  
  
  RESULTS
  There was no significant difference in onset time between the two groups. The Dur 25%, the recovery index and the time of recovery of the TOF ratios to 70% were all prolonged in the obstructive jaundice group compared with the control group. The plasma concentration of rocuronium at 60, 90 and 120 min after bolus administration was significantly higher in the obstructive jaundice group.
  
  
  CONCLUSIONS
  The neuromuscular blockade by rocuronium is prolonged in obstructive jaundice patients, and therefore precautions should be taken in case of postoperative residual neuromuscular block. The possible reason is impedance of rocuronium excretion due to biliary obstruction and increased plasma unbound rocuronium because of free bilirubin competing with it for albumin binding.
authors.affiliation: Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Zhen-Meng
authors.initials: ZM
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Mi-Jia
authors.initials: MJ
authors.lastname: Lin
authors.forename: Bo
authors.initials: B
authors.lastname: Tan
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Qiu
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Yu
mesh_terms: D000328:Adult; D000732:Androstanols / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D000077123:Rocuronium
chemical_list: D000732:Androstanols; D000077123:Rocuronium