title: Role of adipokines signaling in the modulation of T cells function.
abstract: The field that links immunity and metabolism is rapidly expanding. Apparently non-immunological disorders such as obesity and type 2 diabetes have been linked to immune dysregulation, suggesting that metabolic alterations can be induced by or be consequence of an altered self-immune tolerance. In this context, adipose tissue produces and releases a variety of pro-inflammatory and anti-inflammatory factors, termed "adipokines," which can be considered as the bridge between obesity-related exogenous factors, such as nutrition and lifestyle, and the molecular events leading to metabolic syndrome, inflammatory, and/or autoimmune conditions. In obesity, increased production of most adipokines impacts on multiple functions such as appetite and energy balance, modulation of immune responses, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism, and so on. This report aims to discuss some of the recent topics of adipocytokine research and their related signaling pathways, that may be of particular importance as could lead to effective therapeutic strategies for obesity-associated diseases.
authors.affiliation: Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno , Salerno , Italy ; Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR) , Napoli , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Procaccini
authors.forename: Veronica
authors.initials: V
authors.lastname: De Rosa
authors.forename: Mario
authors.initials: M
authors.lastname: Galgani
authors.forename: Fortunata
authors.initials: F
authors.lastname: Carbone
authors.forename: Claudia
authors.initials: C
authors.lastname: La Rocca
authors.forename: Luigi
authors.initials: L
authors.lastname: Formisano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matarese
keywords: T cells; adipocytokines; adiponectin; leptin; obesity