title: Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study.
abstract: BACKGROUND
  Amlapitta Mishran suspension is a poly herbal ayurvedic formulation, which has been traditionally used for acidity and gastric ulcers.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the antiulcer activity of Amlapitta Mishran on non-steroidal anti-inflammatory drugs (NSAID's) -induced ulcers in the rat model.
  
  
  METHODS
  The antiulcer activity of Amlapitta Mishran was investigated on indomethacin (100 mg/kg) NSAID's induced ulcers in rats. Effect of two different doses of Amlapitta Mishran was studied by calculating the total number of ulcers, ulcer index and percentage inhibition.
  
  
  METHODS
  Data was analyzed by the Student's t-test (P < 0.05).
  
  
  RESULTS
  Amlapitta Mishran treated rats have shown significant (P < 0.0001) decrease in the total number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with positive control group.
  
  
  CONCLUSIONS
  The results indicate that Amlapitta Mishran has showed a dose dependent antiulcer activity in experimental animals and confirms ayurvedic use of Amlapitta Mishran in gastric ulcers.
authors.affiliation: Biomedical Services, Shree Dhootapapeshwar Ayurvedic Research Foundation, Navi Mumbai, Maharashtra, India.
authors.forename: Sampath K
authors.initials: SK
authors.lastname: Vemula
authors.forename: Mukesh B
authors.initials: MB
authors.lastname: Chawada
authors.forename: Kapil S
authors.initials: KS
authors.lastname: Thakur
authors.forename: Mahesh K
authors.initials: MK
authors.lastname: Vahalia
keywords: Antiulcer activity; cyclooxygenase; gastric ulcers; indomethacin