title: Synthetic thioamide, benzimidazole, quinolone and derivatives with carboxylic acid and ester moieties: a strategy in the design of antituberculosis agents.
abstract: Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron-withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.
authors.forename: M
authors.initials: M
authors.lastname: Ashfaq
authors.forename: S S A
authors.initials: SS
authors.lastname: Shah
authors.forename: T
authors.initials: T
authors.lastname: Najam
authors.forename: M M
authors.initials: MM
authors.lastname: Ahmad
authors.forename: R
authors.initials: R
authors.lastname: Tabassum
authors.affiliation: Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. chashfaq_@hotmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Rivera
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D004952:Esters; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013854:Thioamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D001562:Benzimidazoles; D002264:Carboxylic Acids; D004952:Esters; D015363:Quinolones; D013854:Thioamides; C031000:benzimidazole