title: Hemodynamic correlates of low umbilical cord vitamin D and ionized calcium.
abstract: Vitamin D deficiency and hypocalcemia are associated with gestational hypertension. Therefore, we hypothesized that umbilical cord [Ca(2+)] and [vitamin D] are correlated with perinatal blood pressures. Mothers and newborns comprised vitamin D sufficient (vitamin D ≥ 50 nM, range 52-111 nM, n = 14), and vitamin D deficient groups (vitamin D < 50 nM, range 13-49 nM, n = 29). Cord [Ca²⁺] was negatively correlated with maternal systolic pressure (SBP) (r = -0.56, p < 0.01) and positively correlated with neonatal SBP (r = +0.55, p < 0.01) in the vitamin D deficient group. We conclude that low umbilical cord [vitamin D] and [Ca²⁺] may predispose mothers to higher and newborns to lower blood pressures.
authors.affiliation: Division of Neonatology, Department of Pediatrics and Child Health .
authors.forename: Inez
authors.initials: I
authors.lastname: Reeves
authors.forename: Grace
authors.initials: G
authors.lastname: Rosario
authors.forename: Michal
authors.initials: M
authors.lastname: Young
authors.forename: Kerry
authors.initials: K
authors.lastname: Lewis
authors.forename: Kareem
authors.initials: K
authors.lastname: Washington
authors.forename: Richard M
authors.initials: RM
authors.lastname: Millis
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002118:Calcium / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006439:Hemodynamics; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000503:physiopathology; D007022:Hypotension / Q000097:blood / Q000151:congenital / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000503:physiopathology
chemical_list: D014807:Vitamin D; D002118:Calcium
keywords: Blood pressure; ionized calcium; neonatology; pregnancy; umbilical cord blood; vitamin D