title: Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study.
abstract: BACKGROUND
  Our previous studies have showed that the rs5888 single nucleotide polymorphism (SNP) in Scavenger receptor class B type 1 (SCARB1) gene is associated with serum lipid levels in the general Chinese populations. The present study was undertaken to detect the associations between rs5888 SNP and the risk of coronary artery disease (CAD) and ischemic stroke (IS).
  
  
  METHODS
  A total of 1,716 unrelated subjects (CAD, 601; IS, 533; and healthy controls, 582) were included in this study. Genotyping of the rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism.
  
  
  RESULTS
  The genotypic frequencies of SCARB1 rs5888 SNP were different between CAD patients and controls, the subjects with TT genotype had high risk of CAD (OR = 1.76, P = 0.038 for TT vs. CC; and OR = 1.75, P = 0.036 for TT vs. CC/CT). There was no significant association between genotypes and the risk of IS. Further analysis showed that the subjects with TT genotype in the total population had lower levels of high-density lipoprotein cholesterol than the subjects with CC/CT genotypes (P < 0.05), the subjects with TT genotype in controls but not in CAD or IS patients had higher levels of serum LDL-C and ApoB than those with CC genotype (P < 0.05 for each).
  
  
  CONCLUSIONS
  The present study suggests that the SCARB1 rs5888 SNP influences serum lipid levels, and is associated with the risk of CAD.
authors.affiliation: 1. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Wu
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Cao
authors.forename: Wu-Xian
authors.initials: WX
authors.lastname: Chen
authors.forename: Lynn Htet Htet
authors.initials: LH
authors.lastname: Aung
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ke-Ke
authors.initials: KK
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Zeng
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D051122:Scavenger Receptors, Class B / Q000235:genetics*; D020521:Stroke / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D008055:Lipids; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B
keywords: Coronary artery disease; Ischemic stroke; Lipid; Scavenger receptor class B type 1 gene; Single nucleotide polymorphism