title: Aerosol-assisted plasma deposition of hydrophobic polycations makes surfaces highly antimicrobial.
abstract: The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
authors.forename: Harris
authors.initials: H
authors.lastname: Liu
authors.forename: Yoojeong
authors.initials: Y
authors.lastname: Kim
authors.forename: Kerrianne
authors.initials: K
authors.lastname: Mello
authors.forename: John
authors.initials: J
authors.lastname: Lovaasen
authors.forename: Apoorva
authors.initials: A
authors.lastname: Shah
authors.forename: Norman
authors.initials: N
authors.lastname: Rice
authors.forename: Jacqueline H
authors.initials: JH
authors.lastname: Yim
authors.forename: Daphne
authors.initials: D
authors.lastname: Pappas
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Klibanov
mesh_terms: D000336:Aerosols / Q000138:chemical synthesis* / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005898:Glass / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry*; D000071228:Polyelectrolytes; D011094:Polyethyleneimine / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects
chemical_list: D000336:Aerosols; D000890:Anti-Infective Agents; D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine