title: 131I therapy using rhTSH stimulation and dosimetry in metastatic malignant struma ovarii.
abstract: A 38-year-old woman with metastatic malignant struma ovarii, including massive liver metastases and retroperitoneal lymphadenopathy, underwent ovarian resection and retroperitoneal lymph nodes excision, partial hepatectomy, and radiofrequency ablation for liver metastases. She underwent thyroidectomy and received three I treatments using recombinant human thyrotropin stimulation and radioiodine dosimetry. posttherapy I imaging, anatomic images, and thyroglobulin levels showed significant diminution in the tumor burdens and remarkable decline in thyroglobulin levels. This case provided valuable information on recombinant human thyrotropin-assisted I ablation in conjunction with dosimetry in an unusual presentation of iodine-avid malignant struma ovarii with bulky metastases.
authors.affiliation: From the *Department of Radiology, University of Washington Medical Center, Seattle; †Division of Gynecologic Oncology, Group Health Bellevue Medical Center, Bellevue, WA; and ‡Division of Nuclear Medicine & Clinical Molecular Imaging, Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA.
authors.forename: Jinchun
authors.initials: J
authors.lastname: Yan
authors.forename: David H
authors.initials: DH
authors.lastname: Lewis
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Benoit
authors.forename: Janet F
authors.initials: JF
authors.lastname: Eary
authors.forename: David A
authors.initials: DA
authors.lastname: Mankoff
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011874:Radiometry; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013330:Struma Ovarii / Q000473:pathology* / Q000628:therapy*; D013972:Thyrotropin / Q000627:therapeutic use*
chemical_list: D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin