title: Novel and emerging therapies safeguarding health of humans and their companion animals: a review.
abstract: Modern medicine has helped to a great extent to eradicate and cure several diseases of mankind and animals. But the existence of incurable diseases like cancer, Acquired Immunodeficiency Syndrome (AIDS), diabetes or rheumatoid arthritis, side effects of allopathic medicine, increasing trend of antibiotic resistance and chemicals and biopesticides causing dietary risk have made the situation more critical than ever before. Thus, it has become a matter of concern for the scientists and researchers to develop novel therapies. Bacteriophage therapy to treat pathogenic bacterial infections, virophage therapy for conservation of global system and avian egg yolk antibody therapy for designing prophylactic strategies against Gastrointestinal (GI) diseases are interesting approaches. Others include the use of cytokines as adjunctive immunomodulators, gene therapy focusing on diseases caused by single gene defects, RNAi technology to suppress specific gene of interest and apoptins for cancer treatment. Stem cell therapy against several diseases and ailments has also been discussed. The use of nanoparticles for better drug delivery, even though costly, has been given equal importance. Nevertheless, immunomodulation, be it through physiological, chemical or microbial products, or through essential micronutrients, probiotics, herbs or cow therapy prove to be cost-effective, causing minimum adverse reactions when compared to allopathy. Development in the field of molecular biology has created an enormous impact on vaccine development. The present review deals with all these novel and emerging therapies essential to safeguard the health of humans and companion animals.
authors.affiliation: Division of Pathology, Indian Veterinary Research Institute, Iztnagar, Bareilly,. U.P., 243122, India.
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Dhama
authors.forename: Sandip
authors.initials: S
authors.lastname: Chakraborty
authors.lastname: Mahima
authors.forename: Mohd Yaqoob
authors.initials: MY
authors.lastname: Wani
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Verma
authors.forename: Rajib
authors.initials: R
authors.lastname: Deb
authors.forename: Ruchi
authors.initials: R
authors.lastname: Tiwari
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kapoor
mesh_terms: D000818:Animals; D017209:Apoptosis; D001435:Bacteriophages; D002417:Cattle; D016207:Cytokines / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D057805:Pets; D034622:RNA Interference; D013234:Stem Cells / Q000166:cytology*; D014612:Vaccines / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D014612:Vaccines