title: The role of protein kinase CK2 in glioblastoma development.
abstract: Glioblastoma is the most prevalent and malignant primary brain tumor in adults, and its response to current therapies is limited. Protein kinase CK2 is overexpressed in glioblastoma and regulates glioblastoma cell survival, proliferation, and migration and brain tumorigenesis. Targeting CK2 for glioblastoma treatment may benefit patients with glioblastoma.
authors.affiliation: Authors' Affiliations: Brain Tumor Center and Department of Neuro-Oncology; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center; and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas.
authors.forename: Haitao
authors.initials: H
authors.lastname: Ji
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000201:enzymology*; D047390:Casein Kinase II / Q000235:genetics; D005260:Female; D005909:Glioblastoma / Q000201:enzymology*; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*; D010619:Phenazines; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines; D010619:Phenazines; C555142:silmitasertib; C570325:CSNK2A1 protein, human; D047390:Casein Kinase II