title: [18F]fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates.
abstract: The mono-[(18)F]fluorination of o-carborane via nucleophilic substitution is reported. The new radiochemical transformation uses cyclotron produced [(18)F]F(-) and a carboranyl iodonium salt. Further derivatization of the (18)F-labelled carborane is achieved by formation of the C(c)-lithio salt and reaction with an aldehyde.
authors.affiliation: Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, Parque Tecnológico de San Sebastian, 20009, San Sebastian, Spain. jllop@cicbiomagune.es.
authors.forename: Kiran B
authors.initials: KB
authors.lastname: Gona
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gómez-Vallejo
authors.forename: Daniel
authors.initials: D
authors.lastname: Padro
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D017357:Cyclotrons; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals