title: Acute kidney injury due to tubular intraluminal monoclonal light chain crystals mimicking acute pyelonephritis.
abstract: Tubular intraluminal inflammatory cells may be seen in kidney biopsies of patients with pyelonephritis, cell-mediated transplant rejection, autoimmune tubulointerstitial nephritis, allergic reactions, or in association with monoclonal light chain casts. When casts in a native kidney are primarily composed of granulocytes, the cause is most commonly acute pyelonephritis due to an ascending bacterial urinary tract infection. We report a 57-year-old man with acute kidney injury and an intense intraluminal neutrophil response to monoclonal lambda light chain crystal containing casts.
authors.affiliation: Department of Nephrology, University of Medicine and Dentistry , New Jersey, Newark, NJ , USA and.
authors.forename: Mumnoon
authors.initials: M
authors.lastname: Haider
authors.forename: Steven P
authors.initials: SP
authors.lastname: Salvatore
authors.forename: Joshua
authors.initials: J
authors.lastname: Kaplan
authors.forename: Surya V
authors.initials: SV
authors.lastname: Seshan
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis*; D001536:Bence Jones Protein / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D007680:Kidney Neoplasms / Q000175:diagnosis*; D007684:Kidney Tubules / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis*; D009504:Neutrophils / Q000276:immunology*; D011704:Pyelonephritis / Q000175:diagnosis
chemical_list: D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein