title: Therapeutic Efficacy and Safety of GH in Japanese Children with Down Syndrome Short Stature Accompanied by GH Deficiency.
abstract: In this study, we investigated the effects of GH treatment in children with Down syndrome who had been diagnosed with GH deficiency (GHD). A total of 20 subjects were investigated in this study. Fourteen Down syndrome children (5 boys and 9 girls) with short stature due to GHD were treated with GH at Okayama Red Cross General Hospital, and 6 Down syndrome children (4 boys and 2 girls) with short stature due to GHD were registered in the Pfizer International Growth Database (KIGS). Height SD score (SDS) increased throughout the three-year GH treatment period. The overall mean height SDS increased from -3.5 at baseline to -2.5 after 3 yr of treatment. The mean change in height SDS during these 3 yr was 1.1. In addition, height assessment of SD score based on Down syndrome-specific growth data in the Japanese population revealed that the height SDS (Down syndrome) also increased across the 3-yr GH treatment period. The mean change in height SDS (Down syndrome) during these three years was 1.3. GH therapy was effective for Down syndrome short stature accompanied by GHD, and no new safety concerns were found in this study.
authors.affiliation: Department of Pediatrics, Okayama Red Cross General Hospital, Okayama, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Meguri
authors.forename: Masaru
authors.initials: M
authors.lastname: Inoue
authors.forename: Koji
authors.initials: K
authors.lastname: Narahara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sato
authors.forename: Ami
authors.initials: A
authors.lastname: Takata
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ohki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ozono
keywords: Down syndrome; GH deficiency (GHD); GH treatment; height SDS