title: Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core.
abstract: The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.
authors.affiliation: Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan. jthuang@chem.sinica.edu.tw.
authors.forename: Gerard Chun-Hao
authors.initials: GC
authors.lastname: Liu
authors.forename: Bryan Po-Wen
authors.initials: BP
authors.lastname: Chen
authors.forename: Nancy Ting-Juan
authors.initials: NT
authors.lastname: Ye
authors.forename: Chih-Hsien
authors.initials: CH
authors.lastname: Wang
authors.forename: Wenlung
authors.initials: W
authors.lastname: Chen
authors.forename: Hsien-Ming
authors.initials: HM
authors.lastname: Lee
authors.forename: Sunney I
authors.initials: SI
authors.lastname: Chan
authors.forename: Joseph Jen-Tse
authors.initials: JJ
authors.lastname: Huang
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D005452:Fluoresceins / Q000737:chemistry / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D000682:Amyloid; D004268:DNA-Binding Proteins; D005452:Fluoresceins; D008081:Liposomes; D010455:Peptides; C007740:fluorexon