title: A systematic review of Gymnema sylvestre in obesity and diabetes management.
abstract: The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies.
authors.affiliation: Division of Animal Biochemistry, National Dairy Research Institute, Karnal, -132001, (Haryana), India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Pothuraju
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Sharma
authors.forename: Jayasimha
authors.initials: J
authors.lastname: Chagalamarri
authors.forename: Surender
authors.initials: S
authors.lastname: Jangra
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar Kavadi
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism; D019422:Dietary Sucrose / Q000037:antagonists & inhibitors / Q000378:metabolism; D019587:Dietary Supplements / Q000009:adverse effects / Q000032:analysis; D031104:Gymnema sylvestre / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D007408:Intestinal Absorption / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008082:Lipotropic Agents / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use; D012997:Solvents / Q000737:chemistry; D014315:Triterpenes / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D019422:Dietary Sucrose; D007004:Hypoglycemic Agents; D008082:Lipotropic Agents; D010936:Plant Extracts; D012503:Saponins; D012997:Solvents; D014315:Triterpenes; C007898:gymnemic acid
keywords: Gymnema sylvestre; diabetes; metabolism; obesity