title: Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics.
abstract: The Cosmetic Ingredient Review Expert Panel assessed the safety of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics, finding that these ingredients are safe in cosmetic formulations in the present practices of use and concentration. Both ingredients are lanolin substitutes and are reported to function in cosmetics as skin-conditioning agents--emollients. The Panel reviewed available animal and clinical data in making its determination of safety.
authors.affiliation: Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. Email: cirinfo@cir-safety.org.
authors.forename: Monice M
authors.initials: MM
authors.lastname: Fiume
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000272:Adipates / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics; D004643:Emollients / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D009152:Mutagenicity Tests; D012867:Skin / Q000187:drug effects
chemical_list: D000272:Adipates; D003358:Cosmetics; D004643:Emollients
keywords: bis-diglyceryl polyacyladipate; cosmetics; safety