title: Toxicological assessment of green petroleum coke.
abstract: Green petroleum coke is primarily inorganic carbon with some entrained volatile hydrocarbon material. As part of the petroleum industry response to the high production volume challenge program, the potential for reproductive effects was assessed in a subchronic toxicity/reproductive toxicity screening test in rats (OECD 421). The repeated-dose portion of the study provided evidence for dust accumulation and inflammatory responses in rats exposed to 100 and 300 mg/m(3) but there were no effects at 30 mg/m(3). In the reproductive toxicity screen, the frequency of successful matings was reduced in the high exposure group (300 mg/m(3)) and was not significantly different from control values but was outside the historical experience of the laboratory. The postnatal observations (external macroscopic examination, body weight, and survival) did not indicate any treatment-related differences. Additional tests conducted to assess the potential hazards to aquatic (fish, invertebrates, and algae) and soil dwelling organisms (earthworms and vascular plants) showed few effects at the maximum loading rates of 1000 mg coke/L in aquatic studies and 1000 mg coke/kg soil in terrestrial studies. The only statistically significant finding was an inhibition of algal growth measured as either biomass or growth rate.
authors.affiliation: ExxonMobil Biomedical Sciences, Inc, 1545 U.S. Highway 22 East, Annandale, NJ 08801-3059, USA. Email: richard.h.mckee@exxonmobil.com.
authors.forename: Richard H
authors.initials: RH
authors.lastname: McKee
authors.forename: Deborah
authors.initials: D
authors.lastname: Herron
authors.forename: Patrick
authors.initials: P
authors.lastname: Beatty
authors.forename: Paula
authors.initials: P
authors.lastname: Podhasky
authors.forename: Gary M
authors.initials: GM
authors.lastname: Hoffman
authors.forename: James
authors.initials: J
authors.lastname: Swigert
authors.forename: Carol
authors.initials: C
authors.lastname: Lee
authors.forename: Diana
authors.initials: D
authors.lastname: Wong
mesh_terms: D000818:Animals; D003077:Coke / Q000633:toxicity*; D005260:Female; D006838:Hydrocarbons / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010578:Petroleum / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: D003077:Coke; D006838:Hydrocarbons; D010578:Petroleum
keywords: 64741-79-3; petroleum coke; toxicity assessment