title: Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model.
abstract: Immune activation plays a critical role in HIV-1 pathogenesis, but the pathways that are responsible for HIV-1-associated immune activation are not well understood. Recent advances in the development of a humanized mouse model for HIV-1 infection might provide new approaches to study the mechanisms of HIV-1 associated immune activation, and to test interventions aimed at reducing HIV-1 pathogenesis.
authors.affiliation: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Harvard Medical School, Boston.
authors.forename: J Judy
authors.initials: JJ
authors.lastname: Chang
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology*; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D051193:Toll-Like Receptors / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors
keywords: HIV-1; TLR; humanized mouse; innate immunity; pathogenesis