title: Effects of supplementation of antioxidant vitamins and lipid peroxidation in critically ill patients.
abstract: BACKGROUND
  Critical patients present systemic inflammatory process that can be followed by decrease in plasma concentrations of antioxidant vitamins.
  
  
  OBJECTIVE
  [corrected] The aim of this study was to evaluate the effect of the supplementation of antioxidant vitamins in critical patients and their relation with lipid peroxidation.
  
  
  METHODS
  23 patients went on a standard diet (G1) and 11 went on a diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C (G2). The APACHE II score was made. Serum concentrations of retinol, β-carotene, vitamins C and E, malondialdehyde (MDA) and C-reactive protein was measured before (T0) and on the 8th day after the beginning of the nutritional therapy (T1). The groups had been monitored on T0, T1 and T2, (at discharges or death) on the following parameters: mechanical ventilation; hospitalization days; mortality; infection incidence.
  
  
  RESULTS
  Serum concentrations of MDA and vitamin E were significantly lower in G2 after intervention and strong tendency to increase vitamin C. There were not significant differences between the groups regarding the clinical parameters.
  
  
  CONCLUSIONS
  The doses of vitamin A, C and E that were indicated were effective for the current lipid peroxidation reduction.
authors.affiliation: Center of Research for Micronutrients (NPqM). Department of Nutrition. Josué de Castro Institute of Nutrition. Rio de Janeiro Federal University (UFRJ). Rio de Janeiro. Brazil.
authors.forename: Carla R
authors.initials: CR
authors.lastname: Nogueira
authors.forename: Fernanda
authors.initials: F
authors.lastname: Borges
authors.forename: Edson
authors.initials: E
authors.lastname: Lameu
authors.forename: Carlos
authors.initials: C
authors.lastname: Franca
authors.forename: Andréa
authors.initials: A
authors.lastname: Ramalho
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D016638:Critical Illness; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D001205:Ascorbic Acid