title: Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey.
abstract: Resistant infections lead to increased necessity of searching novel drugs and drug combinations. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in Turkey for antipyretic and analgesic purposes. Lavandula stoecheas subsp. cariensis, Phlomis nissolii, Phlomis bourgaei, Phlomis leucophracta, Centaurea hierapolitana, Centaurea polyclada, Centaurea lydia, Scrophularia cryptophila, Scrophularia depauperata, Scrophularia floribunda, Rubia davisiana, and Alkanna tinctoria subsp. subleiocarpa were investigated for their in vivo antimalarial activities in mice infected with Plasmodium yoelii. Two hundred fifty to 500 mg/kg doses of plant extracts were given to mice as a single daily dose for 4 days. P. nissolii water extract, C. lydia chloroform extract, S. cryptophila ethanol extract, and C. polyclada methanol extract showed antimalarial activity with reducing parasitaemia. The chemotherapeutic effects of plant extracts ranged between 13.5% and 66.91%. The chemosuppressions exerted by combined plant extracts of P. nissolii, S. cryptophila, and C. lydia with C. polyclada methanol extract were detected as 51.25%, 57.33%, and 58.33%, respectively. Investigation of cytotoxic activities against brine shrimps revealed that methanol extract of C. polycada, chloroform extract of C. lydia, and ethanol extract of S. cryptophila showed cytotoxic activities, while water extract of P. nissolii was not active against brine shrimps.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozbilgin
authors.forename: Cenk
authors.initials: C
authors.lastname: Durmuskahya
authors.forename: Husniye
authors.initials: H
authors.lastname: Kayalar
authors.forename: Ipek
authors.initials: I
authors.lastname: Ostan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D005260:Female; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018512:Parasitemia / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D010967:Plasmodium yoelii / Q000187:drug effects; D023382:Toxicity Tests, Acute; D014421:Turkey
chemical_list: D000962:Antimalarials; D010936:Plant Extracts