title: A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats.
abstract: BACKGROUND
  Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced nephrotoxicity.
  
  
  METHODS
  Pathological damage score, kidney weight, BUN, and Cr of 227 rats that were involved in different projects were determined. A total of 187 rats were treated with 7 mg/kg cisplatin and sacrificed 1 week later.
  
  
  RESULTS
  There was a good significant correlation between normalized kidney weight and logarithmic scale of BUN and Cr. Relationship between BUN, Cr or normalized kidney weight and pathology damage score was significant.
  
  
  CONCLUSIONS
  Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats.
authors.affiliation: Water and Electrolytes Research Center, Isfahan, Iran ; Department of Physiology, Isfahan, Iran ; Kidney Diseases Research Center, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ashrafi
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pezeshki
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Eshraghi
authors.forename: Maryam
authors.initials: M
authors.lastname: Haghighi
keywords: Cisplatin; kidney weight; nephrotoxicity; pathology; rat