title: Changes in serum levels of bone morphogenic protein 4 and inflammatory cytokines after bariatric surgery in severely obese korean patients with type 2 diabetes.
abstract: Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P = 0.024). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.
authors.affiliation: Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of Korea.
authors.forename: Mee Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Jang
authors.forename: Oak-Kee
authors.initials: OK
authors.lastname: Hong
authors.forename: Hyun-Ji
authors.initials: HJ
authors.lastname: Chun
authors.forename: Soon-Jib
authors.initials: SJ
authors.lastname: Yoo
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Wook
authors.initials: W
authors.lastname: Kim
authors.forename: Eung Kook
authors.initials: EK
authors.lastname: Kim
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Hyuk-Sang
authors.initials: HS
authors.lastname: Kwon