title: Direct amidation from alcohols and amines through a tandem oxidation process catalyzed by heterogeneous-polymer-incarcerated gold nanoparticles under aerobic conditions.
abstract: We describe herein a highly elegant and suitable synthesis of amide products from alcohols and amines through a tandem oxidation process that uses molecular oxygen as a terminal oxidant. Carbon-black-stabilized polymer-incarcerated gold (PICB-Au) or gold/cobalt (PICB-Au/Co) nanoparticles were employed as an efficient heterogeneous catalyst depending on alcohol reactivity and generated only water as the major co-product of the reaction. A wide scope of substrate applicability was shown with 42 examples. The catalysts could be recovered and reused without loss of activity by using a simple operation.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo (113-0033) (Japan), Fax: (+81) 3-5684-0634.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Soulé
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyamura
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
keywords: alcohols; amides; heterogeneous catalysis; nanoparticles; oxidation