title: A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism.
abstract: BACKGROUND
  Secondary erythrocytosis due to androgens is most commonly seen in the context of T replacement therapy in men. Leydig cell ovarian tumors are a rare cause of virilization, erythrocytosis, and thromboembolism.
  
  
  METHODS
  We describe the case of a 55-year-old postmenopausal woman who presented with a 3-year history of frontal balding and virilization and a 5-year history of obstructive sleep apnea. She had not experienced significant alteration in libido or mood. Menstruation had ceased at age 46. She had a history of recurrent pulmonary embolism and unexplained secondary erythrocytosis. Past hematological investigations had not revealed any evidence of malignancy or thrombophilia, and the JAK2 mutation was negative. The serum erythropoietin was mildly elevated at 20.3 mIU/mL (normal range, 3.6-16.6 mIU/mL). The serum T was initially reported (by immunoassays) as >1600 ng/dL (>55 nmol/L). Similarly, serum androstenedione (>1000 ng/dL; >35 nmol/L), estradiol (169 pg/mL; 621 pmol/L), and dehydroepiandrosterone sulfate (348 μg/dL; 9.4 μmol/L) were all elevated for a postmenopausal woman. Repeat analysis of the serum T by mass spectrometry showed an extremely elevated level of 4270 ng/dL (148 nmol/L). Computed tomography scan revealed a 5.0-cm right ovarian tumor. After surgical removal of an ovarian Leydig cell tumor, her virilization, erythrocytosis, and sleep apnea resolved.
  
  
  CONCLUSIONS
  Hyperandrogenism in women should be considered as a rare but important cause of erythrocytosis, recurrent thromboembolism, and sleep apnea. The diagnosis of hyperandrogenism requires a careful history and physical examination because in postmenopausal women, menstrual disturbance does not occur and cosmetic measures may mask overt clinical features.
authors.affiliation: Departments of Endocrinology (P.K., S.C., B.A.C.), Andrology (D.J.H.), and Gynecology (A.H.P.), Concord General Repatriation Hospital, Concord, NSW 2139 Australia; Sydney ANZAC Research Institute (D.J.H.), Concord, NSW 2139, Australia; and The University of Sydney (D.J.H., B.A.C.), Sydney, NSW 2006, Australia.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kozan
authors.forename: Santhi
authors.initials: S
authors.lastname: Chalasani
authors.forename: David J
authors.initials: DJ
authors.lastname: Handelsman
authors.forename: Anne H
authors.initials: AH
authors.lastname: Pike
authors.forename: Bronwyn A
authors.initials: BA
authors.lastname: Crawford
mesh_terms: D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis / Q000209:etiology*; D007984:Leydig Cell Tumor / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis; D011086:Polycythemia / Q000175:diagnosis / Q000209:etiology*; D017698:Postmenopause; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology*; D012008:Recurrence; D012720:Severity of Illness Index