title: [Modulation of transcriptional regulation during bone and cartilage development and their disease].
abstract: Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.
authors.affiliation: Osaka University Graduate School of Dentistry, Department of Molecular and Cellular Biochemistry, Japan.
authors.forename: Riko
authors.initials: R
authors.lastname: Nishimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Hata
authors.forename: Rikako
authors.initials: R
authors.lastname: Takashima
authors.forename: Michiko
authors.initials: M
authors.lastname: Yoshida
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakamura
authors.forename: Junpei
authors.initials: J
authors.lastname: Kida
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yagi
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D001846:Bone Development / Q000235:genetics*; D001847:Bone Diseases / Q000235:genetics*; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000196:embryology* / Q000502:physiology; D050882:CREB-Binding Protein; D002356:Cartilage / Q000196:embryology* / Q000254:growth & development* / Q000502:physiology; D002357:Cartilage Diseases / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics* / Q000502:physiology*; D051858:Forkhead Transcription Factors; D006801:Humans; D007249:Inflammation / Q000235:genetics; D012038:Regeneration / Q000235:genetics; D055758:SOX9 Transcription Factor; D013312:Stress, Physiological / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics* / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; D051858:Forkhead Transcription Factors; D055758:SOX9 Transcription Factor; D014157:Transcription Factors; D050882:CREB-Binding Protein