title: Coestimation of recombination, substitution and molecular adaptation rates by approximate Bayesian computation.
abstract: The estimation of parameters in molecular evolution may be biased when some processes are not considered. For example, the estimation of selection at the molecular level using codon-substitution models can have an upward bias when recombination is ignored. Here we address the joint estimation of recombination, molecular adaptation and substitution rates from coding sequences using approximate Bayesian computation (ABC). We describe the implementation of a regression-based strategy for choosing subsets of summary statistics for coding data, and show that this approach can accurately infer recombination allowing for intracodon recombination breakpoints, molecular adaptation and codon substitution rates. We demonstrate that our ABC approach can outperform other analytical methods under a variety of evolutionary scenarios. We also show that although the choice of the codon-substitution model is important, our inferences are robust to a moderate degree of model misspecification. In addition, we demonstrate that our approach can accurately choose the evolutionary model that best fits the data, providing an alternative for when the use of full-likelihood methods is impracticable. Finally, we applied our ABC method to co-estimate recombination, substitution and molecular adaptation rates from 24 published human immunodeficiency virus 1 coding data sets.
authors.affiliation: 1] School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK [2] Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
authors.forename: J S
authors.identifier: 0000000156702069
authors.initials: JS
authors.lastname: Lopes
authors.affiliation: 1] Departamento de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Spain [2] Centre for Molecular Biology 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Arenas
authors.affiliation: Departamento de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Posada
authors.affiliation: 1] School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK [2] School of Mathematical Sciences and School of Biological Sciences, University of Bristol, University Walk, Bristol, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Beaumont
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000465:Algorithms; D001499:Bayes Theorem; D005075:Biological Evolution; D003198:Computer Simulation; D019143:Evolution, Molecular; D015497:HIV-1 / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic