title: Highly diastereoselective synthesis of 1-carbamoyl-4-aminoindoloazepinone derivatives via the Ugi reaction.
abstract: A one-pot procedure for the highly diastereoselective synthesis of 1-carbamoyl-4-amino-1,2,4,5-tetrahydroindolo[2,3-c]azepin-3-one derivatives is described. Using 2-formyl-L-tryptophan as a bifunctional building block, a catalyst-free Ugi-three-component reaction (Ugi-3CR) was developed to present trisubstituted indoloazepinones in good yields and excellent diastereomeric excess.
authors.affiliation: Department of Organic Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium , and Institute of Organic Chemistry , Polish Academy of Sciences, Kasprzaka Str. 44/52, 01-224 Warsaw, Poland.
authors.forename: Mouhamad
authors.initials: M
authors.lastname: Jida
authors.forename: Cecilia
authors.initials: C
authors.lastname: Betti
authors.forename: Zofia
authors.initials: Z
authors.lastname: Urbanczyk-Lipkowska
authors.forename: Dirk
authors.initials: D
authors.lastname: Tourwé
authors.forename: Steven
authors.initials: S
authors.lastname: Ballet