title: Glycogen synthase kinase 3 beta (GSK3β) at the tip of neuronal development and regeneration.
abstract: Gaining a basic understanding of the inhibitory molecules and the intracellular signaling involved in axon development and repulsion after neural lesions is of clear biomedical interest. In recent years, numerous studies have described new molecules and intracellular mechanisms that impair axonal outgrowth after injury. In this scenario, the role of glycogen synthase kinase 3 beta (GSK3β) in the axonal responses that occur after central nervous system (CNS) lesions began to be elucidated. GSK3β function in the nervous tissue is associated with neural development, neuron polarization, and, more recently, neurodegeneration. In fact, GSK3β has been considered as a putative therapeutic target for promoting functional recovery in injured or degenerative CNS. In this review, we summarize current understanding of the role of GSK3β during neuronal development and regeneration. In particular, we discuss GSK3β activity levels and their possible impact on cytoskeleton dynamics during both processes.
authors.affiliation: Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), University of Barcelona, Baldiri Reixac 15-21, 08028, Barcelona, Spain, oseira@ibecbarcelona.eu.
authors.forename: Oscar
authors.initials: O
authors.lastname: Seira
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Del Río
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology; D038362:Glycogen Synthase Kinase 3 / Q000096:biosynthesis*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000473:pathology; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3