title: Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke - Comparison with dynamic susceptibility contrast enhanced perfusion imaging.
abstract: The purpose of the present study was to present a multi-delay multi-parametric pseudo-continuous arterial spin labeling (pCASL) protocol with background suppressed 3D GRASE (gradient and spin echo) readout for perfusion imaging in acute ischemic stroke. PCASL data at 4 post-labeling delay times (PLD = 1.5, 2, 2.5, 3 s) were acquired within 4.5 min in 24 patients (mean age 79.7 ± 11.4 years; 11 men) with acute middle cerebral artery (MCA) stroke who also underwent dynamic susceptibility contrast (DSC) enhanced perfusion imaging. Arterial transit times (ATT) were estimated through the calculation of weighted delays across the 4 PLDs, which were included in the calculation of cerebral blood flow (CBF) and arterial cerebral blood volume (CBV). Mean perfusion parameters derived using pCASL and DSC were measured within MCA territories and infarct regions identified on diffusion weighted MRI. The results showed highly significant correlations between pCASL and DSC CBF measurements (r > = 0.70, p < = 0.0001) and moderately significant correlations between pCASL and DSC CBV measurements (r > = 0.45, p < = 0.027) in both MCA territories and infarct regions. ASL ATT showed correlations with DSC time to the maximum of tissue residual function (Tmax)(r = 0.66, p = 0.0005) and mean transit time (MTT)(r = 0.59, p = 0.0023) in leptomeningeal MCA territories. The present study demonstrated the feasibility for noninvasive multi-parametric perfusion imaging using ASL for acute stroke imaging.
authors.affiliation: Department of Neurology, UCLA, Los Angeles, CA, USA ; Department of Radiology, UCLA, Los Angeles, CA, USA.
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
authors.forename: Jeffry R
authors.initials: JR
authors.lastname: Alger
authors.forename: Joe X
authors.initials: JX
authors.lastname: Qiao
authors.forename: Matthias
authors.initials: M
authors.lastname: Gunther
authors.forename: Whitney B
authors.initials: WB
authors.lastname: Pope
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Saver
authors.forename: Noriko
authors.initials: N
authors.lastname: Salamon
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
keywords: Acute stroke; Arterial spin labeling (ASL); Dynamic susceptibility contrast (DSC); Ischemia; Multi-delay; Multi-parametric; Perfusion MRI