title: Biological imaging using nanoparticles of small organic molecules with fluorescence emission at wavelengths longer than 1000 nm.
abstract: Embedded in a polymer: A hydrophobic organic molecule that fluoresces in the near-infrared II (NIR-II) region was made water-soluble and biocompatible by its embedment in a polymer nanoparticle, which was then coated with hydrophilic poly(ethylene glycol) chains. The resulting nanoparticles exhibit bright fluorescence in the NIR-II window and high photostability in aqueous media and were used for in vivo imaging in mice.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305 (USA).
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Tao
authors.forename: Guosong
authors.initials: G
authors.lastname: Hong
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shinji
authors.forename: Changxin
authors.initials: C
authors.lastname: Chen
authors.forename: Shuo
authors.initials: S
authors.lastname: Diao
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Antaris
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Yingping
authors.initials: Y
authors.lastname: Zou
authors.forename: Hongjie
authors.initials: H
authors.lastname: Dai
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D010714:Phosphatidylethanolamines; D011108:Polymers; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols
keywords: fluorescence; imaging agents; nanoparticles; near infrared; polymers