title: Cationic antioxidants as a powerful tool against mitochondrial oxidative stress.
abstract: This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants (MitoQ and SkQs). The latter compounds look promising in treating several incurable pathologies as well as aging.
authors.affiliation: Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, Russia. Electronic address: skulach@belozersky.msu.ru.
authors.forename: Vladimir P
authors.initials: VP
authors.lastname: Skulachev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002412:Cations / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012235:Rhodamines / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D002412:Cations; D009943:Organophosphorus Compounds; D017382:Reactive Oxygen Species; D012235:Rhodamines; D014451:Ubiquinone; C429014:mitoquinone; D010971:Plastoquinone
keywords: 10-(6′-plastoquinonyl) decylrhodamine 19; 10-(6′-plastoquinonyl) decyltriphenylphosphonium; 10-(6′-ubiquinonyl) decyltriphenylphosphonium; MitoQ; Mitochondria; Mitochondria-targeted antioxidants; ROS; Reactive oxygen species; Respiratory chain; SkQ1; SkQR1; SkQs; mROS; mitochondrial reactive oxygen species; plastoquinonyl conjugates with penetrating cations; reactive oxygen species; transmembrane electric potential difference; Δψ