title: Cerebrospinal fluid τ protein in differential diagnosis of Alzheimer's disease and vascular dementia in Chinese population: a meta-analysis.
abstract: BACKGROUND
  To assess whether biomarker τ protein could differentiate between Alzheimer's disease (AD) and vascular dementia (VaD).
  
  
  METHODS
  We conducted a comprehensive search to identify studies on τ protein, patients with AD, and patients with VaD. Cerebrospinal fluid (CSF) τ protein levels were compared to discriminate among patients with AD, healthy controls, and patients with VaD by a meta-analysis.
  
  
  RESULTS
  Patients with AD exhibit significantly higher CSF τ protein levels than healthy controls or patients with VaD in the Chinese population.
  
  
  CONCLUSIONS
  Our findings suggested that CSF τ protein levels were found to be significantly associated with AD in the Chinese population. Measurement of τ protein could help in attenuating the strict distinction between AD and VaD.
authors.affiliation: 1The Cadre Ward in Department of Neurology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Yulan
authors.initials: Y
authors.lastname: Tang
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Shen
authors.forename: Luan
authors.initials: L
authors.lastname: Cen
authors.forename: Min
authors.initials: M
authors.lastname: Han
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid* / Q000378:metabolism; D044466:Asian People; D015415:Biomarkers / Q000134:cerebrospinal fluid / Q000378:metabolism; D002986:Clinical Trials as Topic; D015140:Dementia, Vascular / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D016875:tau Proteins / Q000134:cerebrospinal fluid* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins
keywords: Alzheimer’s disease; Chinese population; cerebrospinal fluid; dementia; meta-analysis; vascular dementia; τ protein