title: Prognostic significance of the preoperative serum levels of soluble form of endoglin in gastric cancer patients.
abstract: BACKGROUND
  Gastric cancer is the second commonest cause of cancer-associated deaths in the world. Its molecular markers can be useful not only for the diagnostic pursuit but also for prognostic purposes. Endoglin was proposed as a marker of neovascularization in solid malignancies. A circulating form of endoglin is referred to as soluble endoglin (sol-end).The purpose of this study was to investigate the clinical importance of serum level of soluble form of sol-end in gastric cancer patients.
  
  
  METHODS
  Serum levels of sol-end were measured in 69 healthy controls and in 60 gastric adenocarcinoma patients with ELISA and serum levels of sol-end were compared with clinicopathological features and outcomes in gastric cancer patients.
  
  
  RESULTS
  Serum levels of sol-end in gastric adenocancer patients were significantly higher than in control patients (p<0.001). The serum levels of sol-end did not differ relative to clinical and pathologic criteria.
  
  
  CONCLUSIONS
  Presented data suggest that serum levels of sol-end do not seem to be a valuable tool in the assessment of gastric cancer prognosis (Tab. 1, Ref. 11).
authors.forename: I
authors.initials: I
authors.lastname: Gomceli
authors.forename: M
authors.initials: M
authors.lastname: Tez
authors.forename: E B
authors.initials: EB
authors.lastname: Bostanci
authors.forename: A S
authors.initials: AS
authors.lastname: Kemik
authors.forename: B
authors.initials: B
authors.lastname: Demiriz
authors.forename: M
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D000071063:Endoglin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface
keywords: endoglin, gastric cancer, prognosis.