title: Interstitial fluid homeostasis and pressure: news from the black box.
abstract: Extracellular volume expansion may lead to elevated blood pressure. This long-term adaptation of the vascular bed to extracellular volume overload is considered a multifactorial and not perfectly understood 'autoregulatory' event, which is difficult to measure. In this issue, Ebah and colleagues demonstrate a direct relationship between fluid overload and pressure in CKD patients. Surprise, instead of intravascular volume, interstitial fluids and pressures were measured. Finally!
authors.affiliation: 1] Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA [2] Junior Research Group 2, Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Titze
mesh_terms: D001834:Body Water / Q000378:metabolism*; D004487:Edema / Q000209:etiology*; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D018495:Fluid Shifts; D006801:Humans; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D040521:Subcutaneous Tissue / Q000378:metabolism*; D014882:Water-Electrolyte Balance