title: Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study.
abstract: OBJECTIVE
  To describe loss to follow-up (LTFU) at all stages of the HIV programme.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  The HIV clinic at Hospital National Simão Mendes in Bissau, Guinea-Bissau.
  
  
  METHODS
  A total of 4080 HIV-infected patients.
  
  
  METHODS
  Baseline characteristics, percentages and incidence rates of LTFU as well as LTFU risk factors at four different stages: immediately after HIV diagnosis (stage 1), after the first CD4 cell count and before a follow-up consultation (stage 2), after a follow-up consultation for patients not eligible for antiretroviral treatment (ART; stage 3) and LTFU among patients on ART (stage 4).
  
  
  RESULTS
  Almost one-third of the patients were lost to the programme before the first consultation where ART initiation is decided; during the 7-year observation period, more than half of the patients had been lost to follow-up (overall incidence rate=51.1 patients lost per 100 person-years). Age below 30 years at inclusion was a risk factor for LTFU at all stages of the HIV programme. The biggest risk factors were body mass index <18.5 kg/m(2) (stage 1), male gender (stage 2), HIV-2 infection (stage 3) and CD4 cell count <200 cells/μL (stage 4).
  
  
  CONCLUSIONS
  In this study, LTFU constituted a major problem, and this may apply to other similar ART facilities. More than half of the patients were lost to follow-up shortly after enrolment, possibly implying a high mortality. Thus, retention should be given a high priority.
authors.affiliation: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
authors.forename: Bo Langhoff
authors.initials: BL
authors.lastname: Hønge
authors.forename: Sanne
authors.initials: S
authors.lastname: Jespersen
authors.forename: Pernille Bejer
authors.initials: PB
authors.lastname: Nordentoft
authors.forename: Candida
authors.initials: C
authors.lastname: Medina
authors.forename: David
authors.initials: D
authors.lastname: da Silva
authors.forename: Zacarias José
authors.initials: ZJ
authors.lastname: da Silva
authors.forename: Lars
authors.initials: L
authors.lastname: Ostergaard
authors.forename: Alex Lund
authors.initials: AL
authors.lastname: Laursen
authors.forename: Christian
authors.initials: C
authors.lastname: Wejse