title: [Protective effect of ademetionine 1, 4-butanedisulfonate on liver injury caused by chemotherapeutic agents].
abstract: The aim of this study was to observe the protective effect of ademetionine 1, 4-butanedisulfonate on liver injury caused by chemotherapy in patients with leukemia. The clinical data of protective effect were analyzed retrospectively from January 2010 to April 2012. A total of 62 acute leukemia patients were divided into A group (27 cases) and B group (35 cases), the polyene phosphatidyl choline combined with ademetionine or combined with compound glycyrrhizin were given in A and B group, respectively. The changes of liver function were observed after 2 weeks, 5 patients in B group suffered from acute liver injury were treated by ademetionine as rescue therapy. Liver function was compared before and after treatment. The results showed that ALT and AST levels were significantly reduced in A group (P < 0.05), none of the patients (0/27) suffered from acute liver injury, but 14.29% (5/35) patients in B group suffered from acute liver injury, and liver function could be recovered by substitution treatment of ademetionine (the median time is 8 days, 5-14 days). It is concluded that the protective and therapeutic effect of ademetionine against liver injury caused by chemotherapy in patients with leukemia is better than that of compound glycyrrhizin.
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China; Department of Hematology & Endocrinology, Peking University Aerospace Central Hospital, Beijing 100853, China.
authors.forename: Ya-Min
authors.initials: YM
authors.lastname: Tian
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dou
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
authors.forename: Zi-Long
authors.initials: ZL
authors.lastname: Yao
authors.forename: Qian-Fei
authors.initials: QF
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D005260:Female; D019695:Glycyrrhizic Acid / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012436:S-Adenosylmethionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; C468227:adenosyl-methionine 1,4-butanedisulfonate; D019695:Glycyrrhizic Acid; D012436:S-Adenosylmethionine