title: Fabrication of cysteine-responsive biomimetic single nanochannels by a thiol-yne reaction strategy and their application for sensing in urine samples.
abstract: A photoinitiated thiol-yne click reaction strategy is used to fabricate a novel responsive biomimetic nanochannel platform. It displays a selective response for Cys by way of covalent bond formation on the channel surface. This system can be applied for Cys sensing with high specificity and non-interference performance in complex matrices and human urine samples.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Sun
authors.forename: Cuiping
authors.initials: C
authors.lastname: Han
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Song
authors.forename: Long
authors.initials: L
authors.lastname: Wen
authors.forename: Demei
authors.initials: D
authors.lastname: Tian
authors.forename: Haibing
authors.initials: H
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D015374:Biosensing Techniques; D002021:Buffers; D003545:Cysteine / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008564:Membrane Potentials; D008567:Membranes, Artificial; D018613:Microscopy, Confocal; D058608:Nanopores; D010293:Pargyline / Q000031:analogs & derivatives / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D011093:Polyethylene Terephthalates; D011189:Potassium Chloride / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D014466:Ultraviolet Rays; D014556:Urine / Q000737:chemistry
chemical_list: D002021:Buffers; D007477:Ions; D008567:Membranes, Artificial; D011093:Polyethylene Terephthalates; D011437:Propylamines; C009054:propargylamine; D011092:Polyethylene Glycols; D011189:Potassium Chloride; D010293:Pargyline; D003545:Cysteine
keywords: biomimetics; biosensors; cysteine; single nanochannels; thiol-yne click reaction