title: Obesity and breast cancer: role of inflammation and aromatase.
abstract: Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese.
authors.affiliation: Metabolism and Cancer Laboratory, Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia Departments ofBiochemistry and Molecular Biology Physiology, Monash University, Clayton, Victoria 3168, Australia.
authors.forename: Evan R
authors.initials: ER
authors.lastname: Simpson
authors.forename: Kristy A
authors.initials: KA
authors.lastname: Brown
mesh_terms: D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000276:immunology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000276:immunology; D009765:Obesity / Q000201:enzymology* / Q000276:immunology*
chemical_list: D001141:Aromatase
keywords: PGE2; aromatase; breast cancer; inflammation; obesity