title: Synthesis of rac-Lindenene via a thermally induced cyclopropanation reaction.
abstract: The first synthesis of the sesquiterpene Lindenene is described. A novel non-catalysed intramolecular cyclopropanation reaction between a diazoketone and an unactivated alkene was utilised to construct the relatively labile ketone precursor with complete stereocontrol. This ketone was transformed in three steps into Lindenene.
authors.affiliation: Chemistry Research Laboratory, 12 Mansfield Road. and University of Oxford, Oxford, OX1 3TA, UK. victor.lee@chem.ox.ac.uk.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Fenlon
authors.forename: Michael W
authors.initials: MW
authors.lastname: Jones
authors.forename: Robert M
authors.initials: RM
authors.lastname: Adlington
authors.forename: Victor
authors.initials: V
authors.lastname: Lee
mesh_terms: D000475:Alkenes / Q000737:chemistry; D018360:Crystallography, X-Ray; D003521:Cyclopropanes / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D005663:Furans; D007659:Ketones; D012717:Sesquiterpenes