title: Role of carbonic anhydrases in pathogenic micro-organisms: a focus on Aspergillus fumigatus.
abstract: Aspergillus fumigatus is a ubiquitous saprophytic fungus responsible for organic material decomposition, and plays an important role in recycling environmental carbon and nitrogen. Besides its important role in the environment, this fungus has been reported as one of the most important fungal pathogens in immunocompromised patients. Due to changes in CO2 concentration that some pathogens face during the infection process, studies have been undertaken to understand the pathogenic roles of carbonic anhydrases (CAs), well-known CO2 hydration catalytic enzymes. As a basis for a discussion of the possible roles of CAs in A. fumigatus pathogenicity, this review describes the main characteristics of the A. fumigatus infection and the challenges for its treatment. In addition, it gathers findings from studies with CA inhibitor drugs as anti-infective agents in different pathogens.
authors.affiliation: Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: Jaqueline Moisés
authors.initials: JM
authors.lastname: Tobal
authors.affiliation: Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: Márcia Eliana da Silva Ferreira
authors.initials: MEDSF
authors.lastname: Balieiro
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology*; D001232:Aspergillus fumigatus / Q000201:enzymology*; D002245:Carbon Dioxide / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D002245:Carbon Dioxide; D002256:Carbonic Anhydrases