title: Anti-inflammatory activity of lipoic acid in mice peritonitis model.
abstract: This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S*) level, infiltration of neutrophils and vascular permeability in a model of zymosan-induced peritonitis. The study showed that lipoic acid increased the sulfane sulfur level. Also, it decreased count of neutrophils and inhibition of intensity of early vascular permeability compared to the control group. These studies indicated that LA exhibits antiinflammatory activity. LA serves as a sulfane sulfur acceptor and releases sulfane sulfur in the form of hydrogen sulfide (H2S), which is probably responsible for its anti-inflammatory activity.
authors.affiliation: Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland. gogo167@interia.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zygmunt
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dudek
authors.forename: Anna
authors.initials: A
authors.lastname: Bilska-Wilkosz
authors.forename: Marek
authors.initials: M
authors.lastname: Bednarski
authors.forename: Szczepan
authors.initials: S
authors.lastname: Mogilski
authors.forename: Joanna
authors.initials: J
authors.lastname: Knutelska
authors.forename: Jacek
authors.initials: J
authors.lastname: Sapa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D005122:Exudates and Transudates / Q000166:cytology / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000378:metabolism; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008063:Thioctic Acid / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D008063:Thioctic Acid; D007213:Indomethacin; D006862:Hydrogen Sulfide