title: Co-registered positron emission tomography/computed tomography and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging features of multiple angiosarcoma of the liver.
abstract: Hepatic angiosarcoma is a very rare disease, accounting for only 2% of primary liver malignancy. An 82-year-old man was admitted to our hospital because of jaundice and weight loss. Computed tomography (CT) and magnetic resonance imaging (MRI) showed diffuse and multiple space-occupying lesions. On gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI, the tumor was not enhanced intensely in the arterial phase following contrast injection, and was then gradually enhanced homogeneously. In the delayed phase and hepatobiliary phase, the tumor was completely washed out. Whole-body (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT fusion scanning confirmed metabolic activity with maximum uptake value of 3.64 in the lesions. A liver biopsy showed spindle-shaped tumor cells proliferating along sinusoids, with elongated and hyperchromatic nuclei. Immunohistochemical studies showed tumor cells positive for von Willebrand factor and CD34. These findings were consistent with angiosarcoma of the liver. This case report is the first description of co-registered FDG-PET/CT images and Gd-EOB-DTPA-enhanced MRI of primary hepatic angiosarcoma.
authors.affiliation: Department of Internal Medicine, Kitasato University Medical Center, Saitama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamatani
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Iguchi
authors.forename: Takemichi
authors.initials: T
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tsunoda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohbu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokomori
keywords: angiosarcoma; electron microscopy; gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid; immunohistochemistry; positron emission tomography/computed tomography