title: The difference in relationship between 18F-FDG uptake and clinicopathological factors on thyroid, esophageal, and lung cancers.
abstract: OBJECTIVE
  The aim of this study was to reveal the differences in clinicopathological factors affecting maximum standardized uptake value (SUVmax) between esophageal squamous cell carcinoma (ESCC), non-small-cell lung cancer (NSCLC), and papillary thyroid cancer (PTC).
  
  
  METHODS
  This study consisted of 119 patients with ESCC (n=43), PTC (n=40), or NSCLC (n=36). We investigated the correlations between SUVmax and clinicopathological factors by using Spearman's correlation coefficient and the Kruskal-Wallis test. Multiple regression analysis was used to investigate which clinicopathological factors significantly affected SUVmax in each cancer type.
  
  
  RESULTS
  The SUVmax correlated with glucose transporter-1 (GLUT-1) expression in NSCLC (r=0.536, P=0.007) and ESCC (r=0.597, P<0.001) but not in PTC. The SUVmax correlated with Ki-67 expression in NSCLC (r=0.381, P=0.022) and PTC (r=0.374, P=0.017) but not in ESCC. A high SUVmax was correlated with a higher pathological T stage (p-T stage) in NSCLC (r=0.536) and ESCC (r=0.597, both P<0.001) but not in PTC. An elevated SUVmax was significantly associated with pathological lymph node status (p-N) in NSCLC, but not in ESCC and PTC. In multiple regression analysis, p-T stage and GLUT-1 expression were statistically significant factors in ESCC, and p-T stage was a statistically significant factor in NSCLC. In PTC, Ki-67 showed a statistically significant association with SUVmax.
  
  
  CONCLUSIONS
  SUVmax in NSCLC depended on the tumor invasion area; SUVmax in ESCC depended on tumor depth and GLUT-1 expression; and SUVmax in PTC might be associated with cell proliferation. The biological factors affecting SUVmax differ according to tumor type.
authors.affiliation: aDivision of Nuclear Medicine, PET Center, and Department of Radiology, Kurume University School of Medicine bDepartment of Diagnostic Pathology, Kurume University Hospital cBiostatistics Center dDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine eDepartment of Surgery fDivision of Endocrinology, Department of Internal Medicine gDepartment of Otolaryngology and Facial Maxillary Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawahara
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hattori
authors.forename: Seiji
authors.initials: S
authors.lastname: Kurata
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Azuma
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Shinzo
authors.initials: S
authors.lastname: Takamori
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiromatsu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakashima
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Fujita
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18