title: Effect of HT042, herbal formula, on longitudinal bone growth in spontaneous dwarf rats.
abstract: HT042 is a new herbal prescription consisting of Astragalus membranaceus, Phlomis umbrosa and Eleutherococcus senticosus, which are used in Korean medicine to stimulate growth in children. We investigated the effects of HT042 on the body weight, longitudinal bone growth, and bone length in spontaneous dwarf rats (SDR). Male and female SDRs were divided into three groups: the control group (DW, 10 mL/kg/day), the recombinant human GH group (rhGH; 500 µg/kg/day), and the HT042 (100 mg/kg/day) group. Each group received the respective treatments for 10 days. Body weight was measured on day 10 of treatment. On day 8, tetracycline (20 mg/kg) was injected intraperitoneally into all individuals to form a fluorescent band on the newly synthesized bone. On day 10, femur and tibia lengths were measured using PIXImus. Body weight, longitudinal bone growth, and bone length were not affected in the HT042 group. In contrast, the rhGH group showed significantly increased body weight, longitudinal bone growth, and bone length. In conclusion, HT042 does not act through a GH-like effect to promote longitudinal bone growth.
authors.affiliation: Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea. hckim@khu.ac.kr.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: MiKyung
authors.initials: M
authors.lastname: Song
authors.forename: Donghun
authors.initials: D
authors.lastname: Lee
authors.forename: Jungbin
authors.initials: J
authors.lastname: Song
authors.forename: Sang Woug
authors.initials: SW
authors.lastname: Park
authors.forename: Juyeon
authors.initials: J
authors.lastname: Park
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Park
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Hocheol
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D005260:Female; D005269:Femur / Q000187:drug effects; D008297:Male; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013977:Tibia / Q000187:drug effects
chemical_list: D010936:Plant Extracts