title: Lapatinib and renal impairment: a case report.
abstract: This clinical report describes durable control of disease in a postmenopausal patient receiving hemodialysis and letrozole plus lapatinib since the diagnosis of HER2-positive, estrogen receptor-positive liver metastasis from breast cancer after anastrozole plus trastuzumab failure.
authors.forename: Federico
authors.initials: F
authors.lastname: Piacentini
authors.forename: Claudia
authors.initials: C
authors.lastname: Omarini
authors.forename: Elena
authors.initials: E
authors.lastname: Barbieri
mesh_terms: D000077384:Anastrozole; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary*; D004334:Drug Administration Schedule; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000628:therapy; D006801:Humans; D000077341:Lapatinib; D000077289:Letrozole; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage; D017698:Postmenopause; D011799:Quinazolines / Q000008:administration & dosage; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D006435:Renal Dialysis; D000068878:Trastuzumab; D017211:Treatment Failure; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage; D014463:Ultrasonography
chemical_list: D000077384:Anastrozole; D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D000077341:Lapatinib; D000077289:Letrozole; D009570:Nitriles; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D000068878:Trastuzumab; D014230:Triazoles; C508053:ERBB2 protein, human