title: Ondansetron reduces lasting vestibular deficits in a model of severe peripheral excitotoxic injury.
abstract: Vestibular neuritis is a neuroinflammatory, peripheral vestibular pathology leading to chronic deficits and long-term disability. While current corticosteroid-based therapy does not appear to positively influence the long term outcome for the patient, a recent clinical pilot study suggested a functional vestibuloprotective effect of the anti-emetic ondansetron in the treatment of vestibular neuritis. We here demonstrate that systemic post-insult administration of ondansetron in a novel rat model of severe excitotoxic vestibular insult reproduces the clinically demonstrated functional benefits. This ondansetron-conferred reduction of functional deficits stems from the protection of synapses between sensory hair cells and primary neurons from excitotoxically induced lesion.
authors.affiliation: Sensorion, Montpellier, France.
authors.forename: Jonas
authors.initials: J
authors.lastname: Dyhrfjeld-Johnsen
authors.forename: Sophie
authors.initials: S
authors.lastname: Gaboyard-Niay
authors.forename: Audrey
authors.initials: A
authors.lastname: Broussy
authors.forename: Aurélie
authors.initials: A
authors.lastname: Saleur
authors.forename: Aurore
authors.initials: A
authors.lastname: Brugeaud
authors.forename: Christian
authors.initials: C
authors.lastname: Chabbert
mesh_terms: D000818:Animals; D005260:Female; D007608:Kainic Acid / Q000633:toxicity; D023421:Models, Animal; D017294:Ondansetron / Q000627:therapeutic use*; D051381:Rats; D020338:Vestibular Neuronitis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D017294:Ondansetron; D007608:Kainic Acid
keywords: Vestibule; excitoxicity; functional deficit; neuritis; nystagmus; ondansetron; vertigo