title: Acute serous macular detachment and cystoid macular edema after uncomplicated phacoemulsification using standard dose subconjunctival cefuroxime.
abstract: Acute toxic serous macular detachment after cataract surgery is very rare, and has been described previously with the use of high concentrations of intra-cameral cefuroxime. We report a case of serous macular detachment and cystoid macular edema 1 day after uncomplicated phacoemulsification using standard dose subconjunctival cefuroxime at the end of surgery. Our case demonstrates that subconjunctival cefuroxime may cause retinal toxicity in a similar fashion to intra-cameral cefuroxime, possibly due to entry of the drug into the anterior chamber through the section or trans-scleral absorption. To our knowledge, this is the first report of this complication with subconjunctival administration of cefuroxime.
authors.affiliation: Department of Ophthalmology, Royal Free Hospital , London , UK.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kontos
authors.forename: Danny
authors.initials: D
authors.lastname: Mitry
authors.forename: Susanne
authors.initials: S
authors.lastname: Althauser
authors.forename: Saurabh
authors.initials: S
authors.lastname: Jain
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002386:Cataract / Q000628:therapy; D002444:Cefuroxime / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology*; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime
keywords: Phacoemulsification; retinal toxicity; serous detachment; subconjunctival cefuroxime