title: Rapid determination of tetrabromobisphenol A and its main derivatives in aqueous samples by ultrasound-dispersive liquid-liquid microextraction combined with high-performance liquid chromatography.
abstract: A method of ultrasound-dispersive liquid-liquid microextraction (US-DLLME) combined with high-performance liquid chromatography/variable wavelength detection (HPLC-VWD) has been developed for rapid measuring tetrabromobisphenol A and its five derivatives in water. Parameters affecting the extraction efficiency including the extraction solvents and dispersive solvents and their volume, ionic strength of the sample, and ultrasound time were optimized, and further validated by orthogonal array design (OAD). The optimized conditions provided enrichment factors for analytes of 74-490. Most analytes had linear responses between 2 and 500 μg L(-1), with correlation coefficients (r(2)) of 0.9923-0.9994. Limits of detection were 0.13-0.63 μg L(-1). Relative standard deviations (RSDs) for five replicates ranged from 2.6% to 4.5% for all analytes. When applied to spiked samples of real water, the method provided recoveries of 88.6-106.3% for tap water, 87.8-108.5% for Mi River water, 82.7-113.5% for chemical wastewater, 45.5-115.3% for urine, and 46.4-126.2% for fruit juice, with RSDs (n=5) less than 4%, 6%, 8%, 10%, and 9% respectively.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
authors.forename: Jiyan
authors.initials: J
authors.lastname: Liu
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Xinzhen
authors.initials: X
authors.lastname: Du
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
mesh_terms: D001628:Beverages / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005163:Factor Analysis, Statistical; D005618:Fresh Water / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D059627:Liquid Phase Microextraction / Q000379:methods; D009994:Osmolar Concentration; D011075:Polybrominated Biphenyls / Q000302:isolation & purification* / Q000652:urine; D012997:Solvents; D013010:Sonication; D013997:Time Factors; D062065:Wastewater / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000302:isolation & purification* / Q000652:urine
chemical_list: D011075:Polybrominated Biphenyls; D012997:Solvents; D062065:Wastewater; D014874:Water Pollutants, Chemical; C020806:tetrabromobisphenol A
keywords: Brominated flame retardants; Dispersive liquid–liquid microextraction; High-performance liquid chromatography; Ultrasound-assisted method