title: Clinical outcomes in kidney transplantation patients from deceased donors with acute kidney injury.
abstract: BACKGROUND
  This single-center study sought to examine the clinical outcomes of kidney transplant recipients from donors displaying acute kidney injury (AKI).
  
  
  METHODS
  We analyzed retrospectively the medical records of the donors and recipients of 54 deceased-donor kidney transplantations performed in our center between March 2009 and March 2012.
  
  
  RESULTS
  Among the 54 deceased donors, 36 (66.7%) experienced AKI as determined by the final mean serum creatinine levels measured before graft harvest of 2.66 ± 1.62 mg/dL versus 0.82 ± 0.28 mg/dL among non-AKI donors. The risks of delayed graft function and slow graft function were increased among the AKI versus non-AKI groups in the early post-transplantation period. However, the renal function status of recipients at 3, 6, and 12 months after transplantation was not significantly different between the two groups. Moreover, rejection-free survival rates during the study period were similar. Multivariate analysis revealed an acute rejection episodes (P = .047) and a lower body mass index in the donor relative to the recipient (P = .011) to be independent risk factors predicting poor graft function defined as a 1-year estimated glomerular filtration rate less than 50 mL/min/l.73 m(2). Donor AKI with either a high level (>4.0 mg/dL), an increasing trend of creatinine, or greater severity by the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) classification was not a significant risk factor.
  
  
  CONCLUSIONS
  Transplantation of kidneys from the AKI donors, namely, patients with severely decreased renal function, displayed excellent short-term outcomes. Accordingly, kidney transplantations from deceased donors with AKI should be considered more actively to expand the donor pool in Korea.
authors.affiliation: Department of Surgery, Korea University Anam Hospital, Seoul, Korea.
authors.forename: C W
authors.initials: CW
authors.lastname: Jung
authors.forename: K T
authors.initials: KT
authors.lastname: Park
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: M G
authors.initials: MG
authors.lastname: Kim
authors.forename: S K
authors.initials: SK
authors.lastname: Jo
authors.forename: W
authors.initials: W
authors.lastname: Cho
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002102:Cadaver; D018572:Disease-Free Survival; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014019:Tissue Donors