title: Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease.
abstract: BACKGROUND
  To assess the relationship between regional neocortical atrophy and psychotic symptoms in adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
  
  
  METHODS
  Rates of change in regional neocortical atrophy as measured by longitudinal magnetic resonance imaging scans and the occurrence of psychotic symptoms and/or the long-term use of antipsychotic medications in 389 outpatients with MCI or AD in Alzheimer's Disease Neuroimaging Initiative.
  
  
  RESULTS
  Atrophy rate of 3 specific neocortical regions, lateral frontal, lateral parietal, and anterior cingulate gyrus, was significantly associated with the onset of psychosis including delusions, agitation, wandering, and hallucinations and/or the need for chronic antipsychotic medications. Atrophy rate of the lateral frontal lobe correlated most significantly with onset of psychotic symptoms or need for chronic antipsychotic medications.
  
  
  CONCLUSIONS
  Psychosis was associated with volume loss in specific regions of the lateral frontal and parietal lobes as well as anterior cingulate gyrus.
authors.affiliation: 1Department of Neurosciences, University of California, San Diego, CA, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Rafii
authors.forename: Curtis S
authors.initials: CS
authors.lastname: Taylor
authors.forename: Hyun T
authors.initials: HT
authors.lastname: Kim
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Desikan
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.forename: David
authors.initials: D
authors.lastname: Katibian
authors.forename: James B
authors.initials: JB
authors.lastname: Brewer
authors.forename: Anders M
authors.initials: AM
authors.lastname: Dale
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D001284:Atrophy / Q000503:physiopathology / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Alzheimer’s disease; dementia; neuroimaging; psychosis