title: [Protective effect of oxiracetam on traumatic brain injury in rats].
abstract: OBJECTIVE
  To study the role of oxiracetam on traumatic brain injury in rats.
  
  
  METHODS
  Thirty Wistar rats were randomly divided into 3 groups: sham operation group, model group and treatment group. Feeney method were used to establish traumatic brain injury (TBI) model in rats in model and treatment group, and rats in sham group were only broached without hydraumatic fitted. Rats in treatment group were successive administration for 21 days with oxiracetam (100 mg/kg, ig). Neurologic impairment scores were undertook after operation of 1 d, 4 d, 7 d, 14 d and 21 d, and Morris water maze test were proceeded during 15 to 19 days after operation. Average escape latency, searching time in target quadrant and number of crossing target platform in rats were recorded.
  
  
  RESULTS
  Neurologic impairment scores of rats in treatment group were significantly less than those of model group after operation of 7, 14 and 21 d (P < 0.05). Average escape latency of model group were significantly higher than those of sham operation group and treatment group (P < 0.05, P < 0.01). Searching time in target quadrant and number of crossing target platform of model group were lower than those of sham operation and treatment group (P < 0.05)).
  
  
  CONCLUSIONS
  Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.
authors.affiliation: Department of Neurology Center, Armed Police Logistics College Affiliated Hospital, Tianjin 300162, China. ljw206@126.com
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Li
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Yang
authors.forename: Xu-Yi
authors.initials: XY
authors.lastname: Chen
authors.forename: Hai-Qian
authors.initials: HQ
authors.lastname: Liang
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000523:psychology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011759:Pyrrolidines; C040619:oxiracetam