title: Safety assessment of borosilicate glasses as used in cosmetics.
abstract: The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of calcium sodium borosilicate, calcium aluminum borosilicate, calcium titanium borosilicate, silver borosilicate, and zinc borosilicate as used in cosmetics. These borosilicate glasses function mostly as bulking agents. Available animal and human data were considered along with data from a previous safety assessment of magnesium silicates. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. Data submitted on calcium borosilicate, which is not a cosmetic ingredient, are also included as additional support for the safety of borosilicate glass ingredients. The Panel concluded that borosilicate glasses are safe as cosmetic ingredients in the practices of use and concentration as given in this safety assessment.
authors.affiliation: Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. Email: cirinfo@cir-safety.org.
authors.forename: Lillian C
authors.initials: LC
authors.lastname: Becker
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry / Q000633:toxicity*; D003257:Consumer Product Safety; D003358:Cosmetics; D005898:Glass; D006801:Humans; D009152:Mutagenicity Tests; D017640:Silicates / Q000737:chemistry / Q000633:toxicity*; D012867:Skin / Q000187:drug effects
chemical_list: D001896:Boron Compounds; D003358:Cosmetics; D017640:Silicates
keywords: borosilicates; cosmetics; glasses; safety