title: Association of HSD17B3 and HSD3B1 polymorphisms with acne vulgaris in Southwestern Han Chinese.
abstract: Acne vulgaris is a very common skin disorder. Previous studies have indicated that genetic background factors play key roles in the onset of acne. Our previous investigation implicated several genes in the androgen metabolism pathway with acne vulgaris in the Han Chinese population. Thus, we further investigated genes and genetic variants that play important roles in this pathway for their relationship with the pathology of acne. In this study, a total of 610 subjects, including 403 acne patients and 207 healthy controls, were genotyped for 15 single-nucleotide polymorphisms in HSD3B1 and HSD17B3 genes. This study shows that rs6428829 in HSD3B1 was associated with acne vulgaris in Han patients from Southwest China, even after adjusting for age and sex. The GG genotype was associated with an increased risk of acne vulgaris (p < 0.05) and G allele carriers were associated with an increased risk of acne vulgaris (p < 0.05). In addition, the haplotype AAT in HSD3B1 significantly increased the risk of acne vulgaris in the case-control study (p < 0.05). Furthermore, for another gene in this pathway, HSD17B3, the haplotype H8 was significantly associated with an increased risk of acne vulgaris. Based on these analyses, our study indicates that the cutaneous androgen metabolism-regulated genes HSD3B1 and HSD17B3 increase the susceptibility to acne vulgaris in Han Chinese from Southwest China.
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Wu
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.forename: Jun-Dong
authors.initials: JD
authors.lastname: He
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: He
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics*; D000152:Acne Vulgaris / Q000208:ethnology / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D009097:Multienzyme Complexes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011375:Progesterone Reductase / Q000235:genetics*; D013251:Steroid Isomerases / Q000235:genetics*; D055815:Young Adult
chemical_list: C021425:3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase; D009097:Multienzyme Complexes; D015067:17-Hydroxysteroid Dehydrogenases; C476565:17beta-hydroxysteroid dehydrogenase type 3; D011375:Progesterone Reductase; D013251:Steroid Isomerases