title: [Progress in TcpC research].
abstract: TcpC is a homolog of the Toll/interleukin-1 receptor (TIR) domain and is secreted by uropathogenic E. coli strain CFT073. TcpC can bind to MyD88, hereby exerting inhibitory effects on macrophages. TcpC represents an important virulence factor that promotes bacterial survival and pathogenicity. TcpC plays a critical role in urinary tract infection, particularly in the pathogenesis of pyelonephritis. In this review,the progress and prospects in TcpC research are discussed.
authors.affiliation: Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Pan
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Xin
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000472:pathogenicity; D029968:Escherichia coli Proteins / Q000502:physiology*; D006801:Humans; D051379:Mice; D011704:Pyelonephritis / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology; D037521:Virulence Factors / Q000502:physiology*
chemical_list: D029968:Escherichia coli Proteins; C549538:TcpC protein, E coli; D037521:Virulence Factors