title: Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK.
abstract: microRNAs play critical roles in the progression and metastasis of nonsmall cell lung cancer (NSCLC). miR-92b acts as an oncogene in some malignancies; however, its role in NSCLC remains poorly understood. Here, we found that miR-92b was significantly increased in human NSCLC tissues and cell lines. Inhibition of miR-92b remarkably suppressed cell proliferation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified to be a target of miR-92b. Expression of miR-92b was negatively correlated with RECK in NSCLC tissues. Collectively, miR-92b might promote NSCLC cell growth and motility partially by inhibiting RECK.
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Xiangyang, 441021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lei
authors.forename: Yaping
authors.initials: Y
authors.lastname: Huang
authors.forename: Wenrong
authors.initials: W
authors.lastname: Gong
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058851:GPI-Linked Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference
chemical_list: D058851:GPI-Linked Proteins; C541874:MIRN92 microRNA, human; D035683:MicroRNAs; C115460:RECK protein, human