title: Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity.
abstract: A tandem dienone photorearrangement-cycloaddition (DPC) reaction of novel cyclohexadienone substrates tethered with various 2π and 4π reaction partners resulted in the formation of polycyclic, bridged frameworks. In particular, use of alkynyl ether-tethered substrates led to (3 + 2) cycloaddition to afford strained alkenes which could be further elaborated by intra- and intermolecular cycloaddition chemistry to produce complex, polycyclic chemotypes.
authors.affiliation: Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
authors.forename: Pieter H
authors.initials: PH
authors.lastname: Bos
authors.forename: Mitchell T
authors.initials: MT
authors.lastname: Antalek
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
authors.forename: Corey R J
authors.initials: CR
authors.lastname: Stephenson
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D061565:Cycloaddition Reaction; D053138:Cyclohexenes / Q000737:chemistry*; D008958:Models, Molecular; D055668:Photochemical Processes; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D053138:Cyclohexenes; D011083:Polycyclic Compounds; C507608:cyclohexadienone