title: Safety assessment of decyl glucoside and other alkyl glucosides as used in cosmetics.
abstract: The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 19 alkyl glucosides as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration when formulated to be nonirritating. Most of these ingredients function as surfactants in cosmetics, but some have additional functions as skin-conditioning agents, hair-conditioning agents, or emulsion stabilizers. The Panel reviewed the available animal and clinical data on these ingredients. Since glucoside hydrolases in human skin are likely to break down these ingredients to release their respective fatty acids and glucose, the Panel also reviewed CIR reports on the safety of fatty alcohols and were able to extrapolate data from those previous reports to support safety.
authors.affiliation: Cosmetic Ingredient Review, 1101 17th Street, NW, Suite, 412, Washington, DC 20036, USA. Email: cirinfo@cir-safety.org.
authors.forename: Monice M
authors.initials: MM
authors.lastname: Fiume
authors.forename: Bart
authors.initials: B
authors.lastname: Heldreth
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: Daniel
authors.initials: D
authors.lastname: Liebler
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics; D005960:Glucosides / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D009152:Mutagenicity Tests; D012098:Reproduction / Q000187:drug effects; D012867:Skin / Q000187:drug effects
chemical_list: D003358:Cosmetics; D005960:Glucosides; C504907:decyl glucoside
keywords: decyl glucoside