title: Study on in-vivo anti-tumor activity of Verbena officinalis extract.
abstract: We investigated the anti-tumor effects of Verbena officinalis extract on H22 tumor-bearing mice and its effect on immune function. Mice model of H22 solid tumor was established, the mice were divided into five groups and administered the extract, later, tumors were removed and inhibition rates were calculated; spleens were removed and spleen indices were calculated, and the sheep red blood cell-delayed-type hypersensitivity (SRBC-DTH) and the serum hemolysin level were determined. The Verbena officinalis extract had anti-tumor effect, with the inhibition rate reaching 38.78%, it also increased the spleen index to a certain extent, in addition, the changes in DTA and HA were not obvious compared with the model group. The Verbena officinalis extract had in vivo anti-tumor effect, while causing no damage on the immune function.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
authors.forename: Wei-Zheng
authors.initials: WZ
authors.lastname: Kou
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhi-Fen
authors.initials: ZF
authors.lastname: Wang
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012756:Sheep; D013154:Spleen / Q000187:drug effects; D032412:Verbena
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: H22 mouse; Verbena officinalis extract; immune function; tumor inhibition