title: Association of GGCX gene polymorphism with warfarin dose in atrial fibrillation population in Xinjiang.
abstract: OBJECTIVE
  To study the effects of γ-glutamyl carboxylase (GGCX) rs2592551 polymorphism on warfarin dose in atrial fibrillation patients in Xinjiang region.
  
  
  METHODS
  Polymerase chain reaction - restriction fragment length polymorphism and direct sequencing methods were used to detect the rs2592551 genotype in 269 atrial fibrillation patients with warfarin administration. The effects of different genotypes on warfarin dose were statistically analyzed.
  
  
  RESULTS
  The rs2592551 polymorphism detection results were 136 cases of wild-type homozygous CC genotype (50.56%), 115 cases of heterozygous CT genotype (42.75%), 18 cases of homozygous TT genotype (6.69%). The allele frequency C was 71.93%, T was 28.07%. The stable warfarin dose average was 2.86 ± 0.61 mg/d in patients with CC genotype, 3.59 ± 0.93 mg/d in patients with CT genotype and 4.06 ± 0.88 mg/d in patients with TT genotype. The warfarin dose in different genotypes were compared, there was statistically significant difference between CC and TT, CC and CT (P <0. 05), but the TT and CT showed no significant difference (P > 0.05).
  
  
  CONCLUSIONS
  In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in GGCX gene rs259251 loci required for significantly higher warfarin dose than those with CC genotype. Therefore, rs2592551 polymorphism may one of the factors affecting the warfarin dose in patients with atrial fibrillation.
authors.forename: Xiayizha
authors.initials: X
authors.lastname: Kamali
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P,R, China. muhuyati@163.com.
authors.forename: Muhuyati
authors.initials: M
authors.lastname: Wulasihan
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Wu-Hong
authors.initials: WH
authors.lastname: Lu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Peng-Yi
authors.initials: PY
authors.lastname: He
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D044466:Asian People; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D019735:Carbon-Carbon Ligases / Q000235:genetics*; D054796:Drug Dosage Calculations; D004361:Drug Tolerance / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase