title: Visible-light-mediated nucleophilic addition of an α-aminoalkyl radical to isocyanate or isothiocyanate.
abstract: A visible-light photoredox synthesis of α-amino amide or α-amino thioamide from N,N-dimethylaniline derivatives and aryl isocyanate or aryl isothiocyanate was developed. Bis[2-(4,6-difluorophenyl)pyridinato-C(2),N](picolinato)iridium(III) (FIrpic) was found to be the effective catalyst among six catalysts screened. The reaction involves generation of α-aminoalkyl radicals from tertiary amines, followed by radical addition to the electron-deficient carbon of isocyanate and isothiocyanate.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering, and Materials Science, Soochow University , 199 RenAi Road, Suzhou, Jiangsu, 215123, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Xiangyong
authors.initials: X
authors.lastname: Gu
authors.forename: Pixu
authors.initials: P
authors.lastname: Li