title: Paradoxical embolism causing acute embolic events in a patient with hereditary thrombophilia.
abstract: Paradoxical embolism (PDE) is an uncommon but clinically important entity. In clinical practice, PDE involving multiple organs is a rarely reported occurrence. Herein, we present a case of acute pulmonary embolism complicated by PDE through an atrial septal defect (ASD) causing a series of embolic events. Subsequent laboratory screening confirmed the patient to be a heterozygous carrier of the factor V Leiden mutation that increases the risk for deep venous thrombosis (DVT). The patient was treated with warfarin indefinitely and underwent transcatheter ASD closure and implantation of an inferior vena cava filter.
authors.affiliation: Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren-Min road No. 139, 410011, Changsha, Hunan, China.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.forename: Z F
authors.initials: ZF
authors.lastname: Fang
authors.forename: S H
authors.initials: SH
authors.lastname: Zhou
mesh_terms: D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D006328:Cardiac Catheterization; D003131:Combined Modality Therapy / Q000379:methods; D019320:Embolism, Paradoxical / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome; D016306:Vena Cava Filters; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin