title: Significance of measurable cardiac troponin by high-sensitivity assays in patients with chronic stable heart failure.
abstract: Biological markers released into the bloodstream by the injured cardiac myocytes have contributed over the years to the diagnosis of acute myocardial infarction. Recent evidence suggests that the measurement of even minute amounts of circulating cardiac contractile proteins may be useful in the clinical assessment of patients with heart failure. Here, we briefly discuss the clinical significance of troponin measurement in chronic heart failure, in light of the availability of a new generation of highly sensitive immunoassays that are changing our understanding and interpretation of this syndrome.
authors.affiliation: Department of Cardiovascular Research, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Latini
authors.forename: Serge
authors.initials: S
authors.lastname: Masson
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003935:Diagnostic Techniques, Cardiovascular; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007118:Immunoassay; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T