title: Vitamin D status and its association with antioxidant profiles in diabetic patients: A cross-sectional study in Iran.
abstract: OBJECTIVE
  There are increasing evidences about the relationship between vitamin D status and the control of diabetes. Several studies showed that vitamin D has an antioxidant property. In this study, we aimed to determine the relationship between serum levels of 25-hydroxy vitamin D (25-OH-D) and glycemic, antioxidant profile in diabetes compared to healthy groups.
  
  
  METHODS
  This cross-sectional study was conducted in 100 patients with type 2 diabetes mellitus (T2DM) and 100 healthy controls. Fasting serum levels of 25-OH-D, calcium, phosphorous, parathyroid hormone, glucose, HbA(1C), insulin, homeostasis model assessment of insulin resistance index, total antioxidant capacity (TAC), activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GSH-PX) were measured.
  
  
  RESULTS
  Eighty-two percent of type 2 diabetic patients and 75% of healthy subjects were suffering from vitamin D deficiency or insufficiency. The activities of GR and GSH-PX were higher in diabetic patients compared to control. There was a negative relationship between 25-OH-D and activity of GR, GSH-PX. Also, 25-OH-D had a positive association with activity of SOD in diabetic patients. In the control group, 25-OH-D had an inverse relationship with SOD, GSH-PX, and positively with GR activities.
  
  
  CONCLUSIONS
  Vitamin D deficiency has a high prevalence among Iranian adult population with and without type 2 diabetes. Our results showed that vitamin D may have a beneficial effect on the control of glycemic profiles and oxidative stress in T2DM patients.
authors.affiliation: Department of Cellular and Molecular of Nutrition, School of Nutritional Sciences and Dietetic; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Saedisomeolia
authors.forename: Ehsaneh
authors.initials: E
authors.lastname: Taheri
authors.forename: M
authors.initials: M
authors.lastname: Djalali
authors.forename: A
authors.initials: A
authors.lastname: Djazayeri
authors.forename: M
authors.initials: M
authors.lastname: Qorbani
authors.forename: A
authors.initials: A
authors.lastname: Rajab
authors.forename: B
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D000975:Antioxidants; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase