title: PET/CT shows subjective pain in shoulder joints to be associated with uptake of (18)F-FDG.
abstract: OBJECTIVE
  The aim of the study was to evaluate the capability of fluorine-18-fluorodeoxyglucose (F-FDG)-positron emission tomography (PET)/computed tomography (CT) in the screening of musculoskeletal inflammation and injury of the shoulder region.
  
  
  METHODS
  The study included 122 participants (69 men and 53 women) who complained of shoulder pain at rest and 122 age-matched and sex-matched controls who did not experience pain at rest. Standardized uptake values (SUVs) were calculated for both the left and right shoulders and compared using a four-point visual analog scale of subjective shoulder pain. Correlations between SUVs and uric acid and C-reactive proteins were also evaluated.
  
  
  RESULTS
  SUVs for shoulder joints with rest and/or motion pain were significantly higher than those for pain-free shoulder joints. SUVs associated with mild and severe pain at rest were significantly higher than those associated with absence of pain at rest, and SUVs associated with moderate and severe pain on motion were significantly higher than those associated with absence of motion pain. Furthermore, SUVs were significantly correlated with uric acid in men (β=0.21, P=0.02) and in all participants (β=0.22, P<0.001).
  
  
  CONCLUSIONS
  F-FDG-PET/CT may be useful for the screening of musculoskeletal inflammation and injury of the shoulder region. As shoulder pain is common, especially among elderly individuals, we should carefully consider the necessity of further examination when identifying the uptake of F-FDG in shoulder joints.
authors.affiliation: Departments of aGlobal Health, Medicine and Welfare bRadioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University cDepartment of Rehabilitation, Nishi-Isahaya Hospital dNishi-Isahaya Hospital PET/CT Diagnostic Imaging Center, Nagasaki, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kamasaki
authors.forename: Naomi
authors.initials: N
authors.lastname: Hayashida
authors.forename: Izumi
authors.initials: I
authors.lastname: Miyamoto
authors.forename: Toshiya
authors.initials: T
authors.lastname: Usui
authors.forename: Kenya
authors.initials: K
authors.lastname: Chiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D000070599:Shoulder Injuries; D012785:Shoulder Joint / Q000000981:diagnostic imaging*; D020069:Shoulder Pain / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18