title: Histometric study of resorption on replanted teeth with enamel matrix-derived protein.
abstract: BACKGROUND
  Enamel matrix-derived proteins (Emdogain) stimulate the proliferation of periodontal ligament cells, contributing to their regeneration.
  
  
  OBJECTIVE
  This study was to perform histometric assessment of root surface resorption in replanted teeth with the use of Emdogain®.
  
  
  METHODS
  Male Wistar rats (Rattus norvegicus), weighing 180 to 200 gm, were anesthetized, subjected to extraction of the upper right incisor tooth, which was then replanted into the alveoli with the following treatment: (a) control group--tooth with root canal filled with calcium hydroxide paste and (b) treated group--tooth with root canal filled with enamel matrix-derived protein. The animals were sacrificed 25 days after tooth replantation. The maxilla was processed to obtain thin sections (6 µ) and stained with hematoxylin and eosin. The resorption volume percentage of each dental element was calculated from the cementoenamel junction to the apex.
  
  
  RESULTS
  Quantification of resorption revealed that Emdogaintreated teeth showed a lower percentage of resorption (31.58%) compared to controls (80.48%) (statistically significant values--t-test p-value=0.0431).
  
  
  CONCLUSIONS
  It was concluded that Emdogain used as root canal filling has properties capable of showing a lower percentage of resorption in replanted teeth.
authors.affiliation: Professor, Department of Health Master Program-Dental Materials, University of Southern Santa Catarina, SC, Brazil, Phone: 4884264754, e-mail: marcelo.oliveira@unisul.br.
authors.forename: Marcelo Tomas
authors.initials: MT
authors.lastname: de Oliveira
authors.forename: Luiz Guilherme
authors.initials: LG
authors.lastname: Bentregani
authors.forename: Braulio
authors.initials: B
authors.lastname: Pasternak
authors.forename: Fabio Dagostin
authors.initials: FD
authors.lastname: Cancelier
authors.forename: Diego Rocha
authors.initials: DR
authors.lastname: de Jesus
authors.forename: Gustavo Otoboni
authors.initials: GO
authors.lastname: Molina
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007180:Incisor / Q000601:surgery; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012184:Retrograde Obturation / Q000379:methods; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D018915:Root Canal Preparation / Q000379:methods; D012391:Root Resorption / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D019227:Tooth Apex / Q000473:pathology; D019237:Tooth Cervix / Q000473:pathology; D014081:Tooth Extraction / Q000379:methods; D014090:Tooth Replantation / Q000379:methods*; D019553:Tooth, Nonvital / Q000473:pathology
chemical_list: D003746:Dental Enamel Proteins; D012387:Root Canal Filling Materials; C109069:enamel matrix proteins; D002126:Calcium Hydroxide