title: Clinical profile of Alzheimer's disease: is the age of the patient a decisive factor? Results of the INFLUENCE study.
abstract: Epidemiological and clinical studies suggest that dementia patients aged ≥ 85 years are biologically different from those aged 65-84. This study aimed to assess whether patients (>85 years) have a distinct sociodemographic and clinical profile. Older patients had lower educational achievements, different carer relationships, and were more likely to take memantine/concomitant treatments and be institutionalized. Differences were observed with respect to concomitant disease/other risk factors (depression, dyslipidemia, cardiovascular disease, hypertension). Oldest patients had greater impairment (more severe Global Deterioration Scale stage, lower Mini-Mental State Examination scores). Greater concomitant drug use and younger carers associated with older patients suggest higher management and social costs.
authors.affiliation: Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, Barcelona, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Molinuevo
authors.affiliation: Servicio de Neurología, Hospital San Pedro de Alcántara, Cáceres, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Casado-Naranjo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D017028:Caregivers; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012959:Socioeconomic Factors
keywords: Age; Alzheimer's disease; dementia; sociodemographic; treatment