title: Diagnostic value of 18F-FDG-PET or PET-CT in recurrent cervical cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Accurate detection of recurrent cervical cancer remains a clinical difficulty. This study aims to assess the diagnostic value of PET or PET-computed tomography (PET-CT) using F-fluorodeoxyglucose (F-FDG) in recurrent cervical cancer using a meta-analysis.
  
  
  METHODS
  All published studies in English evaluating the diagnostic value of PET or PET-CT in detecting recurrent cervical cancer were collected. The methodological quality of the included studies was evaluated. Pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver-operating characteristic curves were obtained using statistical software. Twenty studies were included in the meta-analysis.
  
  
  RESULTS
  The meta-analysis showed that the pooled sensitivity and specificity of PET and PET-CT to detect distant metastasis in recurrent cervical cancer were 0.87 [95% confidence interval (CI): 0.80-0.92] and 0.97 (95% CI: 0.96-0.98), respectively. The pooled sensitivity and specificity for local regional recurrence were 0.82 (95% CI: 0.72-0.90) and 0.98 (95% CI: 0.96-0.99), respectively.
  
  
  CONCLUSIONS
  F-FDG-PET and PET-CT are valuable methods for the assessment of recurrent cervical cancer.
authors.affiliation: aDepartment of Obstetric and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China bDepartment of Obstetric and Gynecology, People's Hospital of Shanxi Province, 256 Xi'an Friendship West Road, Shanxi 710068, China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Chu
authors.forename: Ai
authors.initials: A
authors.lastname: Zheng
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.forename: Yali
authors.initials: Y
authors.lastname: Chen
authors.forename: Liping
authors.initials: L
authors.lastname: Bai
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D019788:Fluorodeoxyglucose F18