title: Rodent intestinal epithelial carcinogenesis: pathology and preclinical models.
abstract: Colon cancer is a major human malignancy that afflicts millions of people throughout the world each year. Genetics and diet play large roles in colon carcinogenesis although chemicals may also contribute. For the past 40 years, scientists have studied experimentally induced intestinal carcinogenesis in rodents in order to elucidate the etiology and mechanisms involved. Comparative histopathology has revealed many similarities of rodent and human intestinal cancers. Comparative molecular pathology has also shown genetic similarities. More recently, genetically engineered mice and inflammatory colon cancer models have been used for investigating mechanisms and potential chemopreventive and treatment modalities. This review will focus on comparative histopathology and nonclinical models.
authors.affiliation: 1Global VetPathology, Montgomery Village, Maryland, USA.
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
authors.forename: Piper M
authors.initials: PM
authors.lastname: Treuting
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D012377:Rodentia
keywords: animal model; colitis; colon adenocarcinoma; colon cancer; colorectal cancer; genetically engineered mice; inflammatory bowel disease; mice; nonclinical; preclinical; rats.