title: Change in renal parenchymal volume in living kidney transplant donors.
abstract: OBJECTIVE
  Uninephrectomy would induce compensatory hypertrophy in the remaining kidney. We investigated the relationship between changes in renal parenchymal volume (RPV) and renal function after nephrectomy in living kidney donors.
  
  
  METHODS
  From July 2011 and January 2012, 45 kidney donors were enrolled in this study. Magnetic resonance scanning was performed before surgery, 3 and 7 days postoperatively, and RPV was calculated through disc summarize methods. Participants were followed up for 1 year.
  
  
  RESULTS
  The RPV of the remaining kidney was 118.06 ± 23.51 cm(3) and then increased by 21.23 % to 143.13 ± 25.52 cm(3) at 3 days and by 24.17 % to 146.60 ± 25.86 cm(3) at 7 days. Multivariate regression analysis showed that preoperative RPV is positively related to its initial function (p = 0.037); the RPV at 7 days is directly related to its initial, preoperative size (p < 0.001). With respect to change in postoperative RPV, there is bigger gain in size in smaller kidneys (p = 0.005). The kidneys that has ≥20 % increase RPV after 7 days are more likely to show further increase in GFR at 1 year (p = 0.024).
  
  
  CONCLUSIONS
  Uninephrectomy induced immediately increment in RPV of the remaining kidney. Donors with RPV increase of ≥20 % at 1 week have a more favourable renal function adaptation at 1 year.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang #37, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Turun
authors.initials: T
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Zixing
authors.initials: Z
authors.lastname: Huang
authors.forename: Shaofeng
authors.initials: S
authors.lastname: He
authors.forename: Ruining
authors.initials: R
authors.lastname: Zhao
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009399:Nephrons / Q000033:anatomy & histology* / Q000502:physiology*; D009929:Organ Size; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies
chemical_list: D003404:Creatinine