title: The value of archival tissue blocks in understanding breast cancer biology.
abstract: Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades.
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, , Leeds, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dowsett
authors.forename: Eldo
authors.initials: E
authors.lastname: Verghese
authors.forename: Steven
authors.initials: S
authors.lastname: Pollock
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pollard
authors.forename: Judith
authors.initials: J
authors.lastname: Heads
authors.forename: Andrew
authors.initials: A
authors.lastname: Hanby
authors.forename: Valerie
authors.initials: V
authors.lastname: Speirs
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000266:history / Q000473:pathology*; D047628:Estrogen Receptor alpha / Q000032:analysis; D005260:Female; D016591:Histocytological Preparation Techniques / Q000266:history / Q000639:trends; D049673:History, 20th Century; D006801:Humans; D008499:Medical Records; D060787:Neoplasm Grading; D016612:Paraffin Embedding; D010336:Pathology / Q000266:history / Q000379:methods* / Q000639:trends; D011237:Predictive Value of Tests; D013997:Time Factors; D016707:Tissue Fixation; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha
keywords: BREAST CANCER; BREAST PATHOLOGY; TAXONOMY