title: The methodology of Dynamic Uncertain Causality Graph for intelligent diagnosis of vertigo.
abstract: Vertigo is a common complaint with many potential causes involving otology, neurology and general medicine, and it is fairly difficult to distinguish the vertiginous disorders from each other accurately even for experienced physicians. Based on comprehensive investigations to relevant characteristics of vertigo, we propose a diagnostic modeling and reasoning methodology using Dynamic Uncertain Causality Graph. The symptoms, signs, findings of examinations, medical histories, etiology and pathogenesis, and so on, are incorporated in the diagnostic model. A modularized modeling scheme is presented to reduce the difficulty in model construction, providing multiple perspectives and arbitrary granularity for disease causality representations. We resort to the "chaining" inference algorithm and weighted logic operation mechanism, which guarantee the exactness and efficiency of diagnostic reasoning under situations of incomplete and uncertain information. Moreover, the causal insights into underlying interactions among diseases and symptoms intuitively demonstrate the reasoning process in a graphical manner. These solutions make the conclusions and advices more explicable and convincing, further increasing the objectivity of clinical decision-making. Verification experiments and empirical evaluations are performed with clinical vertigo cases. The results reveal that, even with incomplete observations, this methodology achieves encouraging diagnostic accuracy and effectiveness. This study provides a promising assistance tool for physicians in diagnosis of vertigo.
authors.affiliation: School of Computer Science and Engineering, Beihang University, Beijing 100191, China; Shandong Normal University, Jinan 250014, China. Electronic address: dongcl@act.buaa.edu.cn.
authors.forename: Chunling
authors.initials: C
authors.lastname: Dong
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ningyu
authors.initials: N
authors.lastname: Wang
mesh_terms: D015984:Causality; D006801:Humans; D008954:Models, Biological; D035501:Uncertainty; D014717:Vertigo / Q000175:diagnosis*
keywords: Clinical decision-making; Disease diagnosis; Dynamic Uncertain Causality Graph; Graphical knowledge representation; Probabilistic inference; Vertigo