title: Chronic consumption of three forms of palm oil diets alters glomerular filtration rate and renal plasma flow.
abstract: The effects of chronic consumption of three types of palm oil diets on glomerular filtration rate (GFR), renal plasma flow (RPF) and blood pressure were studied. Wistar rats were randomly assigned into four groups of ten rats each, respectively: control, fresh (FPO), photoxidized (PPO), thermoxidized (TPO) palm oil diet-fed rats. The control group was fed rat chow only, while experimental groups had different palm oil diets at 15% wt/wt for twelve weeks and tap water ad libitum. After the feeding period, GFR, RPF, systolic and diastolic blood pressures were measured. GFR and RPF of the TPO (0.07 ± 0.01 ml/min and 1.50 ± 0.24 ml/min) and PPO (0.14 ± 0.01 and 2.54 ± 0.11) groups were significantly (p < 0.001) reduced compared with control (0.77 ± 0.04 and 5.3 ± 0.30) and FPO (0.81 ± 0.02 and 4.8 ± 0.13) groups. The GFR and RPF of the TPO group was significantly (p < 0.05) higher than that of the PPO group. Systolic and diastolic blood pressures of the TPO group (140 ± 3 mmHg and 106 ± 4 mmHg) were significantly (p < 0.01) increased when compared with the control (112 ± 6.4 and 78 ± 5), FPO (118 ± 5 and 81 ± 6) and PPO (122 ± 5 and 89 ± 5) groups. These results suggest that chronic consumption of TPO and PPO caused a decrease in GFR and RPF, but increased blood pressure in rats, while FPO did not adversely affect blood pressure, GFR and RPF.
authors.affiliation: Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria. nyohazah@yahoo.com.
authors.forename: Favour N
authors.initials: FN
authors.lastname: Beshel
authors.forename: Atim B
authors.initials: AB
authors.lastname: Antai
authors.forename: Eme E
authors.initials: EE
authors.lastname: Osim
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D010084:Oxidation-Reduction; D000073878:Palm Oil; D055668:Photochemical Processes; D010938:Plant Oils / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017595:Renal Plasma Flow / Q000187:drug effects*
chemical_list: D004041:Dietary Fats; D010938:Plant Oils; D000073878:Palm Oil