title: PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation.
abstract: Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG andN-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1) followed by ring-opening polymerization of amino acidN-carboxyanhydrides. Polylactide nanoparticles coated with these am phiphilic dual brush block copolymers showed significantly improved stability in PBS solution compared to those coated with amphiphilic linear block copolymers such as PEG-polylactide and PEG-polypeptides.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xia
authors.forename: Yao
authors.initials: Y
authors.lastname: Lin
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
keywords: N-Carboxyanhydride; NCA; PEG; PEGylation; ROMP; brush polymer; nanoparticle; polypeptide; ring-opening polymerization; self-assembly