title: Investigating river pollution flowing into Dianchi Lake using a combination of GC-MS analysis and toxicological tests.
abstract: Due to the presence of various harmful compounds in polluted water, toxicological tests should be combined to evaluate whether a body of water is polluted. The water quality of four rivers flowing into Dianchi Lake, which is well known for its heavy and lasting pollution, was investigated in this study using a combination of GC-MS analysis and cytotoxicity and mutagenicity tests. GC-MS analysis showed that the rivers investigated contained a variety of chemicals and suggested that severe water pollution existed. In addition, the water obtained from the four rivers induced acute cytotoxicity in CHO cells and dose-dependent mutagenicity in four Salmonella typhimurium strains (TA97, TA98, TA100 and TA102). The integration of GC-MS analysis and short-term in vitro toxicological tests might be a valuable approach that can be used to monitor the health hazards that may result from water pollution.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Xuemei
authors.initials: X
authors.lastname: Li
authors.forename: Mingyang
authors.initials: M
authors.lastname: Hu
authors.forename: Mingming
authors.initials: M
authors.lastname: Miao
authors.forename: Bo
authors.initials: B
authors.lastname: Pan
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D060106:Lakes / Q000737:chemistry; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis* / Q000633:toxicity; D045483:Rivers / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity
chemical_list: D009153:Mutagens; D014874:Water Pollutants, Chemical