title: Complete chorioamniotic separation and persistence of a yolk sac associated with triploidy.
abstract: BACKGROUND
  Triploidy is a highly lethal condition, and is thus very rarely observed in live births. It may result in significant medical risk to the pregnant woman.
  
  
  METHODS
  A 32-year-old multigravid woman presented for prenatal care. Ultrasound examination at 14+3 weeks of gestation revealed a viable fetus with appropriate fetal biometry, but with evidence of chorioamniotic separation (CAS) and persistence of the yolk sac. Two weeks later, repeat ultrasound showed a large multicystic placenta and early fetal symmetrical growth restriction with persistence of CAS and yolk sac, raising the suspicion of fetal aneuploidy. Amniocentesis showed a fetal karyotype of 69,XXX. The histology of the placental tissue was a partial hydatidiform mole.
  
  
  CONCLUSIONS
  Persistence of chorioamniotic separation and yolk sac during the early second trimester cannot be considered a reassuring finding. In such cases, fetal karyotyping should be considered, especially when an additional abnormality is found.
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Teaching and Research Hospital, Antalya, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: Department of Obstetrics and Gynecology, Medstar Hospital, Antalya, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Erol
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Teaching and Research Hospital, Antalya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaca
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D000328:Adult; D002823:Chorion / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology; D016595:Misoprostol / Q000008:administration & dosage; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D057885:Triploidy; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000473:pathology; D015017:Yolk Sac / Q000000981:diagnostic imaging*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol
keywords: chorioamniotic separation; prenatal diagnosis; triploidy; yolk sac