title: Resveratrol stabilized gold nanoparticles enable surface loading of doxorubicin and anticancer activity.
abstract: The green synthesis of gold nanoparticles was achieved by exploiting the antioxidant property of resveratrol (R). The formation of resveratrol stabilized gold nanoparticles (R-GNPs) was confirmed by the observation of the surface plasmon resonance band at 537 nm. The average size of R-GNPs produced in resveratrol medium was ~35nm. The geometrical shape and zeta potential of the gold nanoparticles were spherical and -21.2 mV, respectively. R-GNPs showed excellent stability in saline and other buffers mimicking the physiological pH. The MTT assay using fibroblast cells from explants tissue revealed the biocompatibility of R-GNPs. The cytotoxic activity of doxorubicin loaded R-GNPs against glioma carcinoma cell line (LN 229), showed the suitability of R-GNPs as a carrier for anticancer drugs.
authors.affiliation: Organic Chemistry Laboratory, CSIR - Central Leather Research Institute, Adyar, Chennai 600020, India.
authors.forename: Ranjeet Kumar
authors.initials: RK
authors.lastname: Mohanty
authors.affiliation: Organic Chemistry Laboratory, CSIR - Central Leather Research Institute, Adyar, Chennai 600020, India.
authors.forename: Sathiah
authors.initials: S
authors.lastname: Thennarasu
authors.affiliation: Organic Chemistry Laboratory, CSIR - Central Leather Research Institute, Adyar, Chennai 600020, India; Chemical Laboratory, CSIR - Central Leather Research Institute, Adyar, Chennai 600020, India. Electronic address: abmandal@hotmail.com.
authors.forename: Asit Baran
authors.initials: AB
authors.lastname: Mandal
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology*; D005347:Fibroblasts; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D000077185:Resveratrol; D012996:Solutions; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000494:pharmacology*; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D012996:Solutions; D013267:Stilbenes; D006046:Gold; D004317:Doxorubicin; D000077185:Resveratrol
keywords: Anticancer activity; Doxorubicin; Gold nanoparticles; Resveratrol