title: Ruthenium catalyzed hydrohydroxyalkylation of isoprene with heteroaromatic secondary alcohols: isolation and reversible formation of the putative metallacycle intermediate.
abstract: Heteroaromatic secondary alcohols react with isoprene to form products of hydrohydroxyalkylation in the presence of ruthenium(0) catalysts generated from Ru3(CO)12 and tricyclohexylphosphine, enabling direct conversion of secondary to tertiary alcohols in the absence of premetalated reagents or stoichiometric byproducts. The putative oxaruthenacycle intermediate has been isolated and characterized, and reversible metallacycle formation has been demonstrated.
authors.affiliation: University of Texas at Austin , Department of Chemistry and Biochemistry, Austin, Texas 78712, United States.
authors.forename: Boyoung Y
authors.initials: BY
authors.lastname: Park
authors.forename: T Patrick
authors.initials: TP
authors.lastname: Montgomery
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Garza
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D000478:Alkylation; D002070:Butadienes / Q000737:chemistry*; D002384:Catalysis; D045782:Hemiterpenes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D010420:Pentanes / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D002070:Butadienes; D045782:Hemiterpenes; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D010420:Pentanes; C005059:isoprene; D012428:Ruthenium