title: Do longer formula feeding and later introduction of solids increase risk for pediatric acute lymphoblastic leukemia?
abstract: Milk formula feeding can elevate insulin-like growth factor-1 levels, possibly impacting leukemogenesis. The intent of the current study is to examine the associations between infant feeding practices and age at introduction of solids on risk of childhood acute lymphoblastic leukemia (ALL). Incident cases of infant and childhood (aged ≤14 years) ALL (n = 142) were enrolled in a case-control study. Cases were frequency matched on age, sex, race, and ethnicity to two sets of controls (n = 284 total). Multivariable logistic regression was used to determine the association between infant feeding practices and age at the introduction of solids and the odds ratio of ALL. In adjusted multivariable analyses, each additional month of formula feeding was associated with a 1.17 (1.09-1.25) odds ratio; each additional month of age at introduction of solids was associated with a 1.18 (1.07-1.30) odds ratio. In this study, longer duration of formula feeding and later age at the introduction of solid foods were independently associated with increased risk of ALL. Additional studies are needed to address the factors influencing duration of formula feeding and delayed introduction of solids. The results support the potential role of energy balance in early life as a contributor to risk for pediatric acute lymphoblastic leukemia.
authors.affiliation: Department of Nutrition, University of Texas at Austin, 1400 Barbara Jordan Blvd., Austin, TX, 78723, USA, schrawj@utexas.edu.
authors.forename: Jeremy Michals
authors.initials: JM
authors.lastname: Schraw
authors.forename: Yong Quan
authors.initials: YQ
authors.lastname: Dong
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Okcu
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.forename: Michele R
authors.initials: MR
authors.lastname: Forman
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007225:Infant Food / Q000009:adverse effects*; D041943:Infant Formula; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*; D012307:Risk Factors