title: Heart failure after transvenous closure of atrial septal defect associated with atrial standstill and thiamine-responsive megaloblastic anemia.
abstract: Despite advances in device closure for atrial septal defect, post-closure heart failure remains a clinical problem in adult patients but is seen only rarely in children. An eight-year-old boy, who had been followed by a local pediatrician with the diagnosis of diabetes mellitus and congenital heart disease, was consulted to us for cardiac re-evaluation. Electrocardiography demonstrated absent P waves, and echocardiography revealed enlargement of the right ventricle and both atria and secundum atrial septal defect. With the diagnosis of atrial standstill, secundum atrial septal defect and thiamine-responsive megaloblastic anemia, acute heart failure developed after transvenous closure of the atrial septal defect, which improved dramatically with thiamine and supportive treatment.
authors.affiliation: Department of Pediatric Cardiology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. vdogan86@yahoo.com.
authors.forename: Vehbi
authors.initials: V
authors.lastname: Doğan
authors.forename: Filiz
authors.initials: F
authors.lastname: Senocak
authors.forename: Utku Arman
authors.initials: UA
authors.lastname: Orün
authors.forename: Ozben
authors.initials: O
authors.lastname: Ceylan
mesh_terms: D000749:Anemia, Megaloblastic / Q000150:complications* / Q000188:drug therapy*; D009202:Cardiomyopathies / Q000097:blood / Q000150:complications*; D002648:Child; D030342:Genetic Diseases, Inborn / Q000097:blood / Q000150:complications*; D006325:Heart Atria / Q000002:abnormalities*; D006327:Heart Block / Q000097:blood / Q000150:complications*; D006333:Heart Failure / Q000097:blood / Q000150:complications*; D006344:Heart Septal Defects, Atrial / Q000097:blood / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D013831:Thiamine / Q000627:therapeutic use*
chemical_list: D013831:Thiamine