title: On Crowd-verification of Biological Networks.
abstract: Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can become unwieldy to manage as their size and complexity increase. This article presents a crowd-verification approach for the visualization and expansion of biological networks. Web-based graphical interfaces allow visualization of causal and correlative biological relationships represented using Biological Expression Language (BEL). Crowdsourcing principles enable participants to communally annotate these relationships based on literature evidences. Gamification principles are incorporated to further engage domain experts throughout biology to gather robust peer-reviewed information from which relationships can be identified and verified. The resulting network models will represent the current status of biological knowledge within the defined boundaries, here processes related to human lung disease. These models are amenable to computational analysis. For some period following conclusion of the challenge, the published models will remain available for continuous use and expansion by the scientific community.
authors.forename: Sam
authors.initials: S
authors.lastname: Ansari
authors.forename: Jean
authors.initials: J
authors.lastname: Binder
authors.forename: Stephanie
authors.initials: S
authors.lastname: Boue
authors.forename: Anselmo
authors.initials: A
authors.lastname: Di Fabio
authors.forename: William
authors.initials: W
authors.lastname: Hayes
authors.forename: Julia
authors.initials: J
authors.lastname: Hoeng
authors.forename: Anita
authors.initials: A
authors.lastname: Iskandar
authors.forename: Robin
authors.initials: R
authors.lastname: Kleiman
authors.forename: Raquel
authors.initials: R
authors.lastname: Norel
authors.forename: Bruce
authors.initials: B
authors.lastname: O'Neel
authors.forename: Manuel C
authors.initials: MC
authors.lastname: Peitsch
authors.forename: Carine
authors.initials: C
authors.lastname: Poussin
authors.forename: Dexter
authors.initials: D
authors.lastname: Pratt
authors.forename: Kahn
authors.initials: K
authors.lastname: Rhrissorrakrai
authors.forename: Walter K
authors.initials: WK
authors.lastname: Schlage
authors.forename: Gustavo
authors.initials: G
authors.lastname: Stolovitzky
authors.forename: Marja
authors.initials: M
authors.lastname: Talikka
keywords: Biological Expression Language; biological network models; community curation; reputation system