title: Facile synthesis of (R)N-2-hydroxyacyl-L-cysteine derivatives: (R)N-2-hydroxyacyl transfer from enzymatically-synthesized (R)S-2-hydroxyacylglutathione derivatives to L-cysteine.
abstract: N-(R)-2-Hydroxyacyl-L-cysteine derivatives were conveniently synthesized by the reaction of the corresponding S-(R)-2-hydroxyacyl-glutathione with cysteine. The (R)2-hydroxyacyl group was transferred from the S-glutathionyl moiety to S-cysteinyl, forming the corresponding (R)S-2-hydroxyacylcysteine; this rearranged to the (R)N-hydroxyacylcysteine. These compounds have anti-proliferative activity associated with the inhibition ofde novo pyrimidine synthesis.
authors.affiliation: Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, Essex, UK.
authors.forename: A
authors.initials: A
authors.lastname: Adesida
authors.forename: L G
authors.initials: LG
authors.lastname: Edwards
authors.forename: P J
authors.initials: PJ
authors.lastname: Thornalley