title: Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.
abstract: Protein kinase C (PKC) belongs to a family of ten serine/threonine protein kinases encoded by nine genes. This family of proteins plays critical roles in signal transduction which results in cell proliferation, survival, differentiation and apoptosis. Due to differential subcellular localization and tissue distribution, each member displays distinct signaling characteristics. In this review, we have summarized the roles of PKC family members in chronic lymphocytic leukemia (CLL). CLL is a heterogeneous hematological disorder with survival ranging from months to decades. PKC isoforms are differentially expressed in CLL and play critical roles in CLL pathogenesis. Thus, isoform-specific PKC inhibitors may be an attractive option for CLL treatment.
authors.affiliation: Translational Cancer Research, Lund University, Medicon Village, Building 404:C3, 223 63, Lund, Sweden, Kazi.Uddin@med.lu.se.
authors.forename: Julhash U
authors.initials: JU
authors.lastname: Kazi
authors.forename: Nuzhat N
authors.initials: NN
authors.lastname: Kabir
authors.forename: Lars
authors.initials: L
authors.lastname: Rönnstrand
mesh_terms: D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology*; D058990:Molecular Targeted Therapy; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D011493:Protein Kinase C