title: Risk factors for early postoperative cognitive dysfunction after non-coronary bypass surgery in Chinese population.
abstract: BACKGROUND
  The present study was performed to investigate the incidence of early postoperative cognitive dysfunction (POCD) after non-coronary bypass surgery and the potential risk factors in Chinese population.
  
  
  METHODS
  We performed a prospective study in a teaching tertiary hospital from May 2012 to August 2012. One hundred and seventy-six adult patients undergoing non-coronary bypass surgery were recruited. Mini-Mental State Examination (MMSE) score was evaluated before and 3 to 5 days after surgery. Patients with a MMSE score reduction of 2 was diagnosed with POCD.
  
  
  RESULTS
  The general incidence of POCD was 33.0%, with no significant difference between the types of surgeries. In the univariate analysis, POCD associated factors included age, duration of surgery, anesthesia, cardiopulmonary bypass (CPB), cross-clamp and rewarming, and sevoflurane concentration. However, only age, cross-clamp duration and sevoflurane concentration were demonstrated to be independent risk factors for POCD.
  
  
  CONCLUSIONS
  Incidence of early POCD after non-coronary bypass surgery was relatively high in Chinese population. Advanced age, longer aortic cross-clamp duration and lower sevoflurane concentration was associated with a higher incidence of POCD.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Lulong
authors.initials: L
authors.lastname: Bo
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Wang
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Zhao
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Xu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Changhai hospital, Second Military Medical University, Shanghai, China. zhuwenzh@gmail.com.
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002681:China; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult