title: Stem cell therapy in amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons, characterized by progressive muscular atrophy and weakness which culminates in death within 2-5 years. Despite various hypotheses about the responsible mechanisms, the etiology of ALS remains incompletely understood. However, it has been recently postulated that stem cell therapy could potentially target several mechanisms responsible for the etiology of ALS and other nervous system disorders, and could be regarded as one of the most promising therapeutic strategies for ALS treatment. We present a brief review of different methods of stem cell therapy in ALS patients and discuss the results with different cell types and routes of administration.
authors.affiliation: Department of Medical Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Rokhsareh
authors.initials: R
authors.lastname: Meamar
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Nasr-Esfahani
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Mousavi
authors.forename: Keivan
authors.initials: K
authors.lastname: Basiri
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000628:therapy*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009046:Motor Neurons / Q000473:pathology*; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: Amyotrophic lateral sclerosis; Cell therapy; Clinical trial; Motor neuron; Stem cell; Transplantation