title: Efficacy and safety of intracameral triamcinolone acetonide to control postoperative inflammation after phacotrabeculectomy.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of intracameral triamcinolone acetonide in phacotrabeculectomy.
  
  
  METHODS
  Beijing Shijitan Hospital, Capital University of Medical Sciences, Beijing, China.
  
  
  METHODS
  Prospective randomized controlled trial.
  
  
  METHODS
  Patients having combined trabeculectomy and cataract surgery were enrolled from March 2010 through January 2012. The patients were randomly divided into 4 groups. At the conclusion of the surgery, Group A received intracameral triamcinolone acetonide 0.5 mg, Group B received triamcinolone acetonide 1.0 mg, Group C received triamcinolone acetonide 2.0 mg. Group D was the control group and did not receive triamcinolone acetonide. All patients had a conventional 2-side trabeculectomy and phacoemulsification with foldable posterior chamber intraocular lens implantation. Visual acuity and clinical indexes of anterior segment inflammation were assessed 1, 7, 14, and 28 days postoperatively.
  
  
  RESULTS
  One hundred twenty-six eyes of 126 patients with a mean age of 64.09 years ± 8.22 (SD) were enrolled. The eyes treated with triamcinolone acetonide had better visual acuity and less anterior chamber inflammation than the control eyes. Intracameral triamcinolone acetonide was highly effective in controlling postoperative inflammation in phacotrabeculectomy, and triamcinolone acetonide 1.0 mg provided the best postoperative result.
  
  
  CONCLUSIONS
  Intracameral injection of triamcinolone acetonide in phacotrabeculectomy resulted in a significant reduction in aqueous inflammation and improvement in visual acuity.
authors.affiliation: From the Department of Ophthalmology, Beijing Shijitan Hospital, Capital University of Medical Sciences, Beijing, China.
authors.forename: Bingsong
authors.initials: B
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Dong
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D056965:Injections, Intraocular; D007429:Intraocular Pressure / Q000502:physiology; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology; D012029:Refraction, Ocular / Q000502:physiology; D014065:Tonometry, Ocular; D014130:Trabeculectomy; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000627:therapeutic use*; D014606:Uveitis, Anterior / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide