title: Role of the B1 bradykinin receptor and gC1qR/p33 in angioedema.
abstract: Patients affected by angioedema (AE) are subject to asymmetric, nonerythematous, nonpruritic, localized, transient, episodic swelling of deeper layers or submucosal tissues of the skin, oropharyngolaryngeal tissue, and/or gastrointestinal wall. The nonapeptide bradykinin (BK) may be largely responsible for the vascular permeability seen in most AE. During AE attacks, activation of the serine proteases leads to the release of BK. Enzymes expressed on the endothelial cell membrane can metabolize BK, producing the agonist of the B1R, which can then be upregulated by proinflammatory stimuli, suggesting that the blockade of B1R and B2R, or gC1q/p33, may provide novel therapeutic targets.
authors.affiliation: Department of Life Sciences, University of Trieste, via Valerio 28, Trieste 34127, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste 34149, Italy. Electronic address: fbossi@units.it.
authors.forename: Fleur
authors.initials: F
authors.lastname: Bossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Tedesco
mesh_terms: D000799:Angioedema / Q000175:diagnosis / Q000378:metabolism*; D001920:Bradykinin / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D024101:Mitochondrial Proteins / Q000378:metabolism*; D043783:Receptor, Bradykinin B1 / Q000378:metabolism*
chemical_list: C087299:C1QBP protein, human; D002352:Carrier Proteins; D024101:Mitochondrial Proteins; D043783:Receptor, Bradykinin B1; D001920:Bradykinin
keywords: Angioedema; BK 1 receptor; BK 2 receptor; Vascular leakage; gC1qR/p33