title: Triazole based ratiometric fluorescent probe for Zn2+ and its application in bioimaging.
abstract: An efficient fluorescent chemosensor 4-((2-hydroxynaphthalen-1-yl)methyleneamino)-3-phenyl-1H-1,2,4-triazole-5(4H)-thione, based on triazole has been designed by condensing 2-hydroxy-1-napthaldehyde with amine, appended to 1,2,4-triazole unit. The probe displays excellent selectivity and sensitivity in both absorbance and fluorescence detection of Zn2+ over other essential metal ions. The nature of fluorescence behavior of receptor upon addition of Zn2+ has been obtained from Density Functional Theory calculations. Imaging experiment indicates that probe works effectively for intracellular Zn2+ imaging with good cell permeability and biocompatibility.
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
authors.forename: Murugan
authors.initials: M
authors.lastname: Iniya
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
authors.forename: Dharmaraj
authors.initials: D
authors.lastname: Jeyanthi
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
authors.forename: Karuppiah
authors.initials: K
authors.lastname: Krishnaveni
authors.affiliation: School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
authors.forename: Ayyavu
authors.initials: A
authors.lastname: Mahesh
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India. Electronic address: dcmku123@gmail.com.
authors.forename: Duraisamy
authors.initials: D
authors.lastname: Chellappa
mesh_terms: D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D014230:Triazoles / Q000737:chemistry*; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D014230:Triazoles; C045575:1,2,4-triazole; D015032:Zinc
keywords: Bioimaging; ESIPT; Fluorescent sensing; Triazole; Zinc