title: [Neuroleptic associated hypothermia: a new case report and study of spontaneous reports to the French pharmacovigilance network].
abstract: BACKGROUND
  Neuroleptics are the main antipsychotic agents used in psychiatric or medicine departments. The occurrence of hyperthermia, particularly in the context of the neuroleptic malignant syndrome, is a well-known side effect of these treatments. Conversely, the occurrence of hypothermia is less known from clinicians.
  
  
  METHODS
  We reported a 72-year-old woman, who presented with hypothermia associated with treatment with neuroleptics. This patient had no other medical comorbidities. Because of persistent hypothermia, altered consciousness and bradycardia, exhaustive diagnostic work-up as well as a prolonged hospitalization were necessary. The results of a review of the national French pharmacovigilance database showed that nearly a quarter (153/614) of drug-related hypothermia are attributed to psychotropic drug, mainly neuroleptics (99/153).
  
  
  CONCLUSIONS
  A better awareness of hypothermia associated to neuroleptics should facilitate early diagnosis and reporting this side effect of neuroleptics.
authors.affiliation: Service de médecine interne, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Huguet
authors.affiliation: Service de médecine interne, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Fongue
authors.affiliation: Service de médecine interne, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: laurent.chiche@ap-hm.fr.
authors.forename: L
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Service des urgences, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Gilly
authors.affiliation: Centre régional de pharmacovigilance Marseille-Provence-Corse, hôpital Sainte-Marguerite, AP-HM, 270, boulevard Saint-Marguerite, 13009 Marseille cedex 9, France.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Pastor
authors.affiliation: Service des urgences, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Michelet
authors.affiliation: Centre régional de pharmacovigilance Marseille-Provence-Corse, hôpital Sainte-Marguerite, AP-HM, 270, boulevard Saint-Marguerite, 13009 Marseille cedex 9, France.
authors.forename: F
authors.initials: F
authors.lastname: Rouby
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards / Q000706:statistics & numerical data; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced*; D060735:Pharmacovigilance
chemical_list: D014150:Antipsychotic Agents
keywords: Adverse drug effect; Antipsychotic agents; Antipsychotiques; Effets indésirables; Hypothermia; Hypothermie; Neuroleptic; Neuroleptiques