title: HIV, EBV, and monoclonal gammopathy.
abstract: In this issue of Blood, Ouedraogo et al have investigated the role of HIV and Epstein-Barr virus (EBV) replication in the persistence of monoclonal gammopathy.1 It has been known for some time that patients with HIV infection have an increased incidence of monoclonal gammopathy and plasma cell dyscrasias.2,3 The exact mechanism of monoclonal gammopathy in patients with HIV infection is unknown, but in many patients the monoclonal gammopathy and other B-cell abnormalities can be reversed with antiretroviral therapy. However, a proportion of patients will have persistent monoclonal gammopathy.
authors.affiliation: NATIONAL INSTITUTES OF HEALTH.
authors.forename: Sham
authors.initials: S
authors.lastname: Mailankody
authors.forename: Ola
authors.initials: O
authors.lastname: Landgren
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D004279:DNA, Viral / Q000037:antagonists & inhibitors*; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010265:Paraproteinemias / Q000188:drug therapy*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D044966:Anti-Retroviral Agents; D004279:DNA, Viral