title: Study on in vitro anti-tumor activity of Bidens bipinnata L. extract.
abstract: We studied the in vitro anti-tumor activity of Bidens Bipinnata L. extract. MTT assay was used to investigate the inhibitory effect of different concentrations of the extracts on human hepatocellular carcinoma (HepG2) cell lines and human cervical carcinoma (Hela) cell lines, and the IC50 values were calculated. The Bidens Bipinnata L. extract had different degrees of inhibitory effects on these two cells, and when exposure time was 48 h, the inhibition rate reached its peak, with IC50 values of 14.80 µg/mL and 13.50 µg/mL respectively. The Bidens Bipinnata L. extract had a good inhibitory effect on human HepG2 cell lines and Hela cell lines, and thus has certain development prospects.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Xinxiang Medical University Weihui, 453100, Henan, China.
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Guo-Ze
authors.initials: GZ
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Tie-Chui
authors.initials: TC
authors.lastname: Zhu
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Gao
authors.forename: Xiao-Ge
authors.initials: XG
authors.lastname: Kou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D031176:Bidens; D005260:Female; D006367:HeLa Cells; D056945:Hep G2 Cells; D018197:Hepatoblastoma / Q000188:drug therapy*; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Bidens Bipinnata L.; MTT; anti-tumor; cell culture