title: The innate and adaptive immunological aspects in neurodegenerative diseases.
abstract: Neurodegenerative diseases affect a considerable percentage of the elderly population. New therapeutic approaches are warranted, aiming to at least delay and possibly reverse disease progression. Strategies to elaborate such approaches require knowledge of specific immune system involvement in disease pathogenesis. In this review, innate and adaptive immunological aspects of neurodegenerative disorders, in particular Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS), are discussed. Initiating disease factors, as well as common mechanistic pathways, are detailed and potential immunological therapeutic targets are identified.
authors.affiliation: Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto School of Medicine, University of Sao Paulo, Brazil.
authors.forename: Maria C O
authors.initials: MC
authors.lastname: Rodrigues
authors.affiliation: Center of Excellence for Aging & Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Psychiatry, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Sanberg
authors.affiliation: Cryopraxis, Cell Praxis, BioRio, Polo de Biotechnologia do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Cruz
authors.affiliation: Center of Excellence for Aging & Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States; Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, United States. Electronic address: sgarbuzo@health.usf.edu.
authors.forename: Svitlana
authors.initials: S
authors.lastname: Garbuzova-Davis
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000378:metabolism
keywords: Adaptive immunity; Alzheimer's disease; Amyotrophic lateral sclerosis; Innate immunity; Neurodegenerative diseases; Parkinson's disease