title: Genomic and epigenomic regulation of adipose tissue inflammation in obesity.
abstract: Chronic inflammation of adipose tissue is viewed as a hallmark of obesity and contributes to the development of type 2 diabetes and cardiovascular disease. According to current models, nutrient excess causes metabolic and structural changes in adipocytes, which initiate transcriptional programs leading to the expression of inflammatory molecules and the subsequent recruitment of immune cells. Recent advances in deciphering the underlying mechanisms revealed that key regulatory events occur at the genomic and epigenomic levels. Here we review these advances because they offer a better understanding of the mechanisms behind the complex obesogenic program in adipose tissue, and because they may help in defining new therapeutic strategies that prevent, restrict, and resolve inflammation in the context of obesity.
authors.affiliation: Institute of Cardiometabolism and Nutrition, Paris 75013, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 872, Team 7 Nutriomique, Paris 75006, France; Université Pierre et Marie Curie-Paris 6, Cordeliers Research Center, Unité Mixte de Recherche (UMR) S872, Paris75006, France.
authors.forename: Amine
authors.initials: A
authors.lastname: Toubal
authors.forename: Eckardt
authors.initials: E
authors.lastname: Treuter
authors.forename: Karine
authors.initials: K
authors.lastname: Clément
authors.forename: Nicolas
authors.initials: N
authors.lastname: Venteclef
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D057890:Epigenomics / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009765:Obesity / Q000378:metabolism
keywords: coregulators; epigenomics; inflammation; metabolism; obesity; transcription