title: CCR5-Delta32: implications in SLE development.
abstract: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the clinical course of the disease. The aim of this study was to evaluate the possible association between the CCR5∆32 base-pair deletion polymorphism and SLE disease in a group of Portuguese patients. A total of 219 patients with SLE and 205 healthy individuals were studied. The frequency of CCR5/∆32 heterozygotes was lower in patients with SLE than in controls (8% vs. 15% OR = 0.5162; P = 0.0319), suggesting a protective association between CCR5∆32 allele and SLE. These results highlight the protective role of Th1 cells that express CCR5 in SLE pathogenesis.
authors.affiliation: UMIB, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS) UPorto, Porto, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Carvalho
authors.forename: S L
authors.initials: SL
authors.lastname: Calvisi
authors.forename: B
authors.initials: B
authors.lastname: Leal
authors.forename: A
authors.initials: A
authors.lastname: Bettencourt
authors.forename: A
authors.initials: A
authors.lastname: Marinho
authors.forename: I
authors.initials: I
authors.lastname: Almeida
authors.forename: F
authors.initials: F
authors.lastname: Farinha
authors.forename: P P
authors.initials: PP
authors.lastname: Costa
authors.forename: B M
authors.initials: BM
authors.lastname: Silva
authors.forename: C
authors.initials: C
authors.lastname: Vasconcelos
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011174:Portugal; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion; D012720:Severity of Illness Index; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5