title: Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer.
abstract: Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-κB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-κB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells.
authors.forename: Weizhou
authors.initials: W
authors.lastname: Zhang
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Grivennikov
mesh_terms: D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D002280:Basal Cell Carcinoma / Q000378:metabolism*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000096:biosynthesis*; D016328:NF-kappa B / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D016328:NF-kappa B