title: The CLUES study: a cluster randomized clinical trial for the evaluation of cardiovascular guideline implementation in primary care.
abstract: BACKGROUND
  The appropriate care for people with cardiovascular risk factors can reduce morbidity and mortality. One strategy for improving the care for these patients involves the implementation of evidence-based guidelines. To date, little research concerning the impact of such implementation strategies in our setting has been published. Aims. To evaluate the effectiveness of a multifaceted tailored intervention in the implementation of three cardiovascular risk-related guidelines (hypertension, type 2 diabetes and dyslipidemia) in primary care in the Basque Health Service compared with usual implementation.
  
  
  METHODS
  A two-year cluster randomized clinical trial in primary care in two districts in the Basque Health Service. All primary care units are randomized. Data from all patients with diabetes, hypertension and those susceptible to coronary risk screening will be analyzed.Interventions. The control group will receive standard implementation. The experimental group will receive a multifaceted tailored implementation strategy, including a specific web page and workshops for family physicians and nurses.Endpoints. Primary endpoints: annual request for glycosylated hemoglobin, basic laboratory tests for hypertension, cardiovascular risk screening (women between 45-74 and men between 40-74 years old). Secondary endpoints: other process and clinical guideline indicators.
  
  
  METHODS
  Data will be extracted from centralized computerized medical records. ANALYSIS will be performed at a primary care unit level weighted by cluster size.
  
  
  CONCLUSIONS
  The main contribution of our study is that it seeks to identify an effective strategy for cardiovascular guideline implementation in primary care in our setting.
  
  
  BACKGROUND
  Current Controlled Trials, ISRCTN88876909.
authors.affiliation: Hernani Health Center, Gipuzkoa Health District, Basque Health Service, c/Aristizabal 1, 20120 Hernani, Spain. arritxuetxe@gmail.com.
authors.forename: Arritxu
authors.initials: A
authors.lastname: Etxeberria
authors.forename: Itziar
authors.initials: I
authors.lastname: Pérez
authors.forename: Idoia
authors.initials: I
authors.lastname: Alcorta
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Emparanza
authors.forename: Elena
authors.initials: E
authors.lastname: Ruiz de Velasco
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Iglesias
authors.forename: Domingo
authors.initials: D
authors.lastname: Orozco-Beltrán
authors.forename: Rafael
authors.initials: R
authors.lastname: Rotaeche
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D050171:Dyslipidemias / Q000517:prevention & control; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D019983:Guideline Adherence / Q000458:organization & administration*; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011320:Primary Health Care / Q000379:methods* / Q000458:organization & administration / Q000592:standards; D040242:Risk Reduction Behavior; D013030:Spain
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human