title: Altered brain response to reward and punishment in adolescents with Anorexia nervosa.
abstract: Adults recovered from Anorexia nervosa (AN) have altered reward modulation within striatal limbic regions associated with the emotional significance of stimuli, and executive regions concerned with planning and consequences. We hypothesized that adolescents with AN would show similar disturbed reward modulation within the striatum and the anterior cingulate cortex, a region connected to the striatum and involved in reward-guided action selection. Using functional magnetic resonance imaging, twenty-two adolescent females (10 restricting-type AN, 12 healthy volunteers) performed a monetary guessing task. Time series data associated with monetary wins and losses within striatal and cingulate regions of interest were subjected to a linear mixed effects analysis. All participants responded more strongly to wins versus losses in limbic and anterior executive striatal territories. However, AN participants exhibited an exaggerated response to losses compared to wins in posterior executive and sensorimotor striatal regions, suggesting altered function in circuitry responsible for coding the affective context of stimuli and action selection based upon these valuations. As AN individuals are particularly sensitive to criticism, failure, and making mistakes, these findings may reflect the neural processes responsible for a bias in those with AN to exaggerate negative consequences.
authors.affiliation: Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Bischoff-Grethe
authors.forename: Danyale
authors.initials: D
authors.lastname: McCurdy
authors.forename: Emily
authors.initials: E
authors.lastname: Grenesko-Stevens
authors.forename: Laura E Zoe
authors.initials: LE
authors.lastname: Irvine
authors.forename: Angela
authors.initials: A
authors.lastname: Wagner
authors.forename: Wai-Ying Wendy
authors.initials: WY
authors.lastname: Yau
authors.forename: Christine
authors.initials: C
authors.lastname: Fennema-Notestine
authors.forename: Christina E
authors.initials: CE
authors.lastname: Wierenga
authors.forename: Julie L
authors.initials: JL
authors.lastname: Fudge
authors.forename: Mauricio R
authors.initials: MR
authors.lastname: Delgado
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D003342:Corpus Striatum / Q000503:physiopathology; D004644:Emotions; D056344:Executive Function; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D011678:Punishment / Q000523:psychology*; D012201:Reward
keywords: Anorexia nervosa; Cingulate; Functional magnetic resonance imaging; Reward; Striatum