title: Large B-cell lymphomas in adolescents and young adults in comparison to adult patients: a matched-control analysis in 55 patients.
abstract: The aim of our study was to assess whether large B-cell lymphoma (LBCL) in adolescents and young adults (AYA) should be considered as a clinocopathological entity, and to evaluate the prognostic value of age. Fifty-five patients aged > 15-30 years were fully matched to 365 adult patients aged 31-65 years. We found a high incidence of primary mediastinal thymic LBCL subtype (33% vs. 5%), while histological transformation was rare (2% vs. 14%). LBCL in AYA presented with a bulky mediastinal mass (51% vs. 21%), and the lactate dehydrogenase (LDH) value was significantly higher (73% vs. 54%). The complete response rate to chemotherapy was similar in the two groups. Five-year overall survival (OS) and event-free survival (EFS) of AYA were 73% and 68%, respectively. The matched-control analysis showed no difference for either OS or EFS. LBCL in AYA presents with some critical features which differ from those of older adults. However, the outcome is equivalent to that observed in older patients.
authors.affiliation: Department of Hematology, Institut J. Paoli-I. Calmettes, Université de la Méditerranée , Marseille , France.
authors.forename: Diane
authors.initials: D
authors.lastname: Coso
authors.forename: Sylvain
authors.initials: S
authors.lastname: Garciaz
authors.forename: Benjamin
authors.initials: B
authors.lastname: Esterni
authors.forename: Florence
authors.initials: F
authors.lastname: Broussais-Guillaumot
authors.forename: Vadim
authors.initials: V
authors.lastname: Ivanov
authors.forename: Thérèse
authors.initials: T
authors.lastname: Aurran-Schleinitz
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Schiano
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Stoppa
authors.forename: Bruno
authors.initials: B
authors.lastname: Chetaille
authors.forename: Didier
authors.initials: D
authors.lastname: Blaise
authors.forename: Norbert
authors.initials: N
authors.lastname: Vey
authors.forename: Réda
authors.initials: R
authors.lastname: Bouabdallah
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
keywords: Large cell lymphoma; adolescents; young adults