title: Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China.
abstract: BACKGROUND
  There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis and fertility outcomes of the patients treated by VRT or ART.
  
  
  METHODS
  Matched-case study based on a prospectively maintained database of patients underwent radical trachelectomy in 10 centres of China was designed to compare the prognosis and fertility outcomes of the patients treated by VRT or ART.
  
  
  RESULTS
  Totally 150 cases, 77 in the VRT and 73 in the ART group, were included. VRT and ART provide similar surgical and pathological outcomes except larger specimens obtained by ART. In the ART group, no patient developed recurrent diseases, but, in the VRT group, 7 (9.8%) patients developed recurrent diseases and 2 (1.6%) patients died of the tumours (P=0.035). The rate of pregnancy in the VRT group was significantly higher than those of ART (39.5% vs 8.8%; P=0.003). The patients with tumour size >2 cm showed significant higher recurrent rate (11.6% vs 2.4%, P<0.05) and lower pregnant rate (12.5% vs 32.1%, P=0.094) compared with the patients with tumour size <2 cm.
  
  
  CONCLUSIONS
  Patients treated by ART obtained better oncology results, but their fertility outcomes were unfavourable compared with VRT. Tumour size <2 cm should be emphasised as an indication for radical trachelectomy for improving the outcome of fertility and prognosis.
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China.
authors.forename: D Y
authors.initials: DY
authors.lastname: Cao
authors.forename: J X
authors.initials: JX
authors.lastname: Yang
authors.forename: X H
authors.initials: XH
authors.lastname: Wu
authors.forename: Y L
authors.initials: YL
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: K J
authors.initials: KJ
authors.lastname: Liu
authors.forename: M H
authors.initials: MH
authors.lastname: Cui
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.forename: Y M
authors.initials: YM
authors.lastname: Wu
authors.forename: B H
authors.initials: BH
authors.lastname: Kong
authors.forename: G H
authors.initials: GH
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Xiang
authors.forename: J H
authors.initials: JH
authors.lastname: Lang
authors.forename: K
authors.initials: K
authors.lastname: Shen
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods*; D009367:Neoplasm Staging; D011247:Pregnancy; D018873:Pregnancy Rate; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D014621:Vagina / Q000473:pathology / Q000601:surgery*; D055815:Young Adult