title: CLOVES syndrome.
abstract: A cohort of patients with overgrowth syndromes has been identified with congenital lipomatous overgrowth, dysregulated fat deposits, and mixed vascular malformations. The acronym CLOVES was given on a heuristic basis to stand for congenital lipomatous overgrowth (CLO), vascular malformation (V), epidermal nevi (E), and scoliosis and spinal deformities (S). These patients have upper limb anomalies with variable phenotypes. Although hand anomalies alone cannot make the diagnosis, the foot, truncal, cutaneous and spinal anomalies are particularly diagnostic. CLOVES syndrome has emerged as a distinct clinical entity diagnosed by clinical and radiographic examinations. The overgrowth pattern is now easily distinguished from other overgrowth syndromes.
authors.affiliation: Division of Plastic Surgery, Boston Children's Hospital; and the Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Boston, MA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Bloom
authors.forename: Joseph
authors.initials: J
authors.lastname: Upton
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000628:therapy; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006228:Hand Deformities, Congenital / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008067:Lipoma / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D009139:Musculoskeletal Abnormalities / Q000175:diagnosis* / Q000628:therapy*; D009506:Nevus / Q000175:diagnosis* / Q000628:therapy*; D010808:Physical Examination / Q000379:methods; D011379:Prognosis; D035583:Rare Diseases; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D054079:Vascular Malformations / Q000175:diagnosis* / Q000628:therapy*
keywords: CLOVES; overgrowth syndromes; vascular anomalies