title: Formation of dihydronaphthalenes via organocatalytic enatioselective Michael-aldol cascade reactions with arylalkanes.
abstract: An organocatalytic highly enantioselective Michael-aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at the ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated to produce highly reactive nulecophilic species in the cascade process under mild conditions.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China , and Department of Chemistry and Chemical Biology, University of New Mexico , Albuquerque, New Mexico 87131-0001, United States.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.forename: Sinan
authors.initials: S
authors.lastname: Wang
authors.forename: Tengfei
authors.initials: T
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000473:Alkanes; D009281:Naphthalenes; C116609:3-hydroxybutanal