title: Tonotopic morphometry of the lamina reticularis of the guinea pig cochlea with associated microstructures and related mechanical implications.
abstract: Morphometry of the lamina reticularis of the guinea pig cochlea was performed using scanning electron microscopy. Seventy-four geometrical parameters of the lamina reticularis, the bundles of stereocilia, and individual stereocilia, in all rows of hair cells and within the individual hair cells, were measured at ten equally spaced locations along the longitudinal direction of the cochlea. Variations of the parameters versus the longitudinal coordinate were statistically analyzed and fitted with polynomials (constant, linear, or quadratic). Our data show that a unique set of geometrical parameters of inner and outer hair cells is typical for every frequency-dependent position at the lamina reticularis. Morphology of the outer hair cell structures varies more than respective parameters of the inner hair cells. Mechanical modeling using the obtained geometrical parameters provides a novel glance at the mechanical characteristics with respect to the cochlear tonotopy.
authors.affiliation: Clinic of Otorhinolaryngology, Department of Medicine, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Germany, dr.yarin@googlemail.com.
authors.forename: Yury M
authors.initials: YM
authors.lastname: Yarin
authors.forename: Andrei N
authors.initials: AN
authors.lastname: Lukashkin
authors.forename: Anton A
authors.initials: AA
authors.lastname: Poznyakovskiy
authors.forename: Heike
authors.initials: H
authors.lastname: Meissner
authors.forename: Mario
authors.initials: M
authors.lastname: Fleischer
authors.forename: Johannes
authors.initials: J
authors.lastname: Baumgart
authors.forename: Claudia
authors.initials: C
authors.lastname: Richter
authors.forename: Eberhard
authors.initials: E
authors.lastname: Kuhlisch
authors.forename: Thomas
authors.initials: T
authors.lastname: Zahnert
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D003051:Cochlea / Q000502:physiology* / Q000648:ultrastructure*; D006168:Guinea Pigs / Q000033:anatomy & histology* / Q000502:physiology*; D006199:Hair Cells, Auditory, Inner / Q000502:physiology / Q000648:ultrastructure; D018072:Hair Cells, Auditory, Outer / Q000502:physiology / Q000648:ultrastructure; D057446:Hydrodynamics; D008297:Male; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D008954:Models, Biological; D059547:Stereocilia / Q000502:physiology* / Q000648:ultrastructure*