title: Natural products as lead structures: chemical transformations to create lead-like libraries.
abstract: In this review, we analyze and illustrate the variation of the two main lead-like descriptors [molecular weight (MW) and the partition coefficient (logP)] in the generation of libraries in which a natural product (NP) is used as the guiding structure. Despite the different approaches used to create NP-like libraries, controlling these descriptors during the synthetic process is important to generate lead-like libraries. From this analysis, we present a schematic approach to the generation of lead-like libraries that can be applied to any starting NP.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
authors.forename: Mauro
authors.initials: M
authors.lastname: Pascolutti
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia. Electronic address: r.quinn@griffith.edu.au.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D008970:Molecular Weight; D054852:Small Molecule Libraries / Q000737:chemistry
chemical_list: D001688:Biological Products; D054852:Small Molecule Libraries