title: Comparison of pregnancy rates in users of extended and cyclic combined oral contraceptive (COC) regimens in the United States: a brief report.
abstract: OBJECTIVE
  To evaluate pregnancy rates with 84/7, 21/7, and 24/4 combined oral contraceptives (COCs).
  
  
  METHODS
  Data were obtained from the i3Invision Data Mart(TM) retrospective claims database. Subjects were 15 to 40 years; first prescribed COCs between January 1, 2006 and April 1, 2011; and continuously insured for ≥1 year. Eighty four over seven users (84/7) were matched 1:1 to 21/7 and 24/4 users.
  
  
  RESULTS
  One-year pregnancy rates were significantly lower with 84/7 than with 21/7 (4.4% vs. 7.3%; p<.0001) and 24/4 (4.4% vs. 6.9%, p<.0001) regimens.
  
  
  CONCLUSIONS
  Preliminary results suggest fewer pregnancies with 84/7 versus 21/7 or 24/4 regimens.
  
  
  CONCLUSIONS
  While newer COCs, including 84/7 and 24/4 regimens, potentially improve efficacy and alter bleeding profiles compared to 21/7 regimens, few data on comparative pregnancy rates with these regimens are available. In this retrospective claims analysis, real-world pregnancy rates were lower with 84/7 regimens versus 21/7 and 24/4 regimens.
authors.affiliation: Teva Global Medical Affairs, 41 Moores Road, Frazer, PA 19355.
authors.forename: Brandon
authors.initials: B
authors.lastname: Howard
authors.forename: James
authors.initials: J
authors.lastname: Trussell
authors.forename: ElizaBeth
authors.initials: E
authors.lastname: Grubb
authors.forename: Maureen J
authors.initials: MJ
authors.lastname: Lage
mesh_terms: D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D014481:United States; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined
keywords: 84/7, 21/7, 24/4 regimens; Contraceptive failure; Hormonal contraception