title: [Collagen abnormalities and endoplasmic reticulum stress in bone and cartilage].
abstract: There are many steps in the post-translational modification of collagen molecules. When abnormality occurs in some step, the unfolded collagen molecules are accumulated in the endoplasmic reticulum (ER) , leading to ER stress. ER stress also occurs downstream of the defective modification of collagen in bone and cartilage. ER stress-induced apoptosis or ER stress response without inducing apoptosis may be associated with the pathogenesis of genetic collagen disorders in bone and cartilage.
authors.affiliation: Laboratory of Laboratory Animal Science and Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Furuichi
authors.forename: Gen
authors.initials: G
authors.lastname: Nishimura
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D000818:Animals; D017209:Apoptosis; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002356:Cartilage / Q000378:metabolism*; D002357:Cartilage Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D003094:Collagen / Q000235:genetics* / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D051379:Mice; D011499:Protein Processing, Post-Translational / Q000235:genetics / Q000502:physiology
chemical_list: D003094:Collagen