title: Modification of chitosan by using samarium for potential use in drug delivery system.
abstract: In the presence of hydroxyl and amine groups, chitosan is highly reactive; therefore, it could be used as a carrier in drug delivery. For this study, chitosan-Sm complexes with different concentrations of samarium from 2.5 to 25 wt.% have been successfully synthesized by the impregnation method. Chitosan combined with Sm3+ ions produced a drug carrier material with fluorescence properties; thus, it could also be used as an indicator of drug release with ibuprofen (IBU) as a model drug. We evaluated the spectroscopic and interaction properties of chitosan and Sm3+ ions, the interaction of chitosan-Sm matrices with IBU as a model drug, and the effect of Sm3+ ions addition on the chitosan ability to adsorb the drug. The result showed that the hypersensitive fluorescence intensity of chitosan-Sm (2.5 wt.%) is higher than the others, even though the adsorption efficiency of chitosan-Sm 2.5wt.% is lower (29.75%) than that of chitosan-Sm 25 wt.% (33.04%). Chitosan-Sm 25 wt.% showed the highest efficiency of adsorption of ibuprofen (33.04%). In the release process of ibuprofen from the chitosan-Sm-IBU matrix, the intensity of orange fluorescent properties in the hypersensitive peak of 4G5/2→6H7/2 transition at 590 nm was observed. Fluorescent intensity increased with the cumulative amount of IBU released; therefore, the release of IBU from the Sm-modified chitosan complex can be monitored by the changes in fluorescent intensity.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, 16424 Depok, Indonesia. Electronic address: ekusrini@che.ui.ac.id.
authors.forename: Eny
authors.initials: E
authors.lastname: Kusrini
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, 16424 Depok, Indonesia.
authors.forename: Rita
authors.initials: R
authors.lastname: Arbianti
authors.affiliation: Department of Metallurgical and Materials Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, 16424 Depok, Indonesia.
authors.forename: Nofrijon
authors.initials: N
authors.lastname: Sofyan
authors.affiliation: Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu Darul Iman, Malaysia.
authors.forename: Mohd Aidil A
authors.initials: MA
authors.lastname: Abdullah
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, 16424 Depok, Indonesia.
authors.forename: Fika
authors.initials: F
authors.lastname: Andriani
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D002412:Cations / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives*; D004337:Drug Carriers / Q000737:chemistry*; D005453:Fluorescence; D007052:Ibuprofen / Q000008:administration & dosage*; D012493:Samarium / Q000737:chemistry*
chemical_list: D018712:Analgesics, Non-Narcotic; D002412:Cations; D004337:Drug Carriers; D012493:Samarium; D048271:Chitosan; D007052:Ibuprofen
keywords: Chitosan; Drug delivery; Fluorescence; Ibuprofen; Samarium