title: Primary amyloid goiter mimicking rapid growing thyroid malignancy.
abstract: Amyloid accumulation in the thyroid gland leading to a clinically detectable mass, known as amyloid goiter, is a rare condition associated with primary amyloidosis. Moreover, a localized primary amyloid goiter involving only the thyroid gland is rarer still. Here, we report a patient with a localized primary amyloid goiter that had grown rapidly, causing dysphagia and dyspnea on exercise, and confused us with malignancy such as anaplastic carcinoma. After surgery, no further symptoms occurred. A diagnosis of amyloid goiter was established on microscopic examination. In patients with a rapidly enlarging thyroid gland presenting with dysphagia, dyspnea, or hoarseness, amyloid goiter and malignancy should both be suspected, even when systemic amyloidosis is not suspected.
authors.affiliation: Department of Internal Medicine, Research Center for Endocrine and Metabolic Diseases, School of Medicine, Chungnam National University, Daejeon, South Korea.
authors.forename: Kyong Hye
authors.initials: KH
authors.lastname: Joung
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Koon Soon
authors.initials: KS
authors.lastname: Kim
authors.forename: Bon Seok
authors.initials: BS
authors.lastname: Koo
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006042:Goiter / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D007828:Laryngoscopy; D008297:Male; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed