title: Novel metal ion-mediated complex imprinted membrane for selective recognition and direct determination of naproxen in pharmaceuticals by solid surface fluorescence.
abstract: A novel metal ion-mediated complex imprinted membrane (CIM) was prepared by immobilization of complex imprinted polymer (CIP) onto a polypropylene membrane. CIP was introduced as a novel imprinted material using a "complex template" constructed with Cu (II) ion and naproxen that could improve the selective recognition and enrichment properties of the membrane in water medium based on the coordination interaction rather than hydrogen bonding interactions, which could make CIP a promising material to mimic biological recognition process. A simple, sensitive and selective solid surface fluorescence method was proposed for the determination of naproxen in pharmaceuticals sample, using the CIM as the recognition material. Under the optimum conditions, the CIM exhibited large adsorption capacity and high selectivity to naproxen. A good linearity was obtained in the range of 0.50-20 mg/L with an estimated detection limit of 0.11 mg/L. Finally, the proposed method was applied to the analysis of naproxen in pharmaceuticals without complicated pretreatment. The recoveries were 85.0% and 89.1% and the RSDs were 9.2% and 12.0%. The results were consistent with that obtained by high performance liquid chromatography. CIM integrated extraction, concentration, and detection into one-step, which could make the analytical procedure more efficient.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Haixian
authors.initials: H
authors.lastname: Lian
authors.forename: Yuling
authors.initials: Y
authors.lastname: Hu
authors.forename: Gongke
authors.initials: G
authors.lastname: Li
mesh_terms: D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002413:Cations, Divalent; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008567:Membranes, Artificial; D054802:Molecular Imprinting / Q000295:instrumentation* / Q000379:methods; D009288:Naproxen / Q000032:analysis*; D011126:Polypropylenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013499:Surface Properties
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002413:Cations, Divalent; D008567:Membranes, Artificial; D011126:Polypropylenes; D009288:Naproxen; D003300:Copper
keywords: Complex imprinted membrane; Metal coordination interaction; Naproxen; Recognition material; Solid surface fluorescence; Water medium