title: A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties.
abstract: Abstract A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
authors.forename: Ivana
authors.initials: I
authors.lastname: Perković
authors.forename: Zrinka Rajić
authors.initials: ZR
authors.lastname: Džolić
authors.forename: Branka
authors.initials: B
authors.lastname: Zorc
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004952:Esters; D011355:Prodrugs / Q000138:chemical synthesis; D014508:Urea / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004952:Esters; D011355:Prodrugs; D014508:Urea