title: [Correction of impairments in functions of anticoagulation and insular systems of an organism by the regulatory peptide Leu-Pro-Gly-Pro].
abstract: It has been established that fivefold intranasal administration of the peptide Leu-Pro-Gly-Pro (1 mg/kg) to rats with developing refractory hyperglycemia leads to restoration and normalization of the functions of anticoagulation and insular systems. In the blood of experimental animals, there was a decrease in the sugar level and platelet aggregation and an increase in anticoagulant and all kinds of fibrinolytic (total, enzymatic, non-enzymatic, Hageman-dependent) activity.
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: T A
authors.initials: TA
authors.lastname: Shubina
authors.forename: M E
authors.initials: ME
authors.lastname: Grigor'eva
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Obergan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D001777:Blood Coagulation / Q000187:drug effects*; D001786:Blood Glucose / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D006943:Hyperglycemia / Q000188:drug therapy / Q000473:pathology; D010455:Peptides / Q000008:administration & dosage*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
chemical_list: D000925:Anticoagulants; D001786:Blood Glucose; D010455:Peptides