title: Current status of drug therapies for osteoporosis and the search for stem cells adapted for bone regenerative medicine.
abstract: A number of factors can lead to bone disorders such as osteoporosis, in which the balance of bone resorption vs. bone formation is upset (i.e., more bone is resorbed than is formed). The result is a loss of bone mass, with a concomitant decrease in bone density. Drugs for osteoporosis can be broadly classified as "bone resorption inhibitors", which impede bone resorption by osteoclasts, and "bone formation accelerators", which augment bone formation by osteoblasts. Here, we describe representative drugs in each class, i.e., the bisphosphonates and the parathyroid hormone. In addition, we introduce two novel bone formation accelerators, SST-VEDI and SSH-BMI, which are currently under investigation by our research group. On the other hand, regenerative therapy, characterized by (ideally) the use of a patient's own cells to regenerate lost tissue, is now a matter of global interest. At present, candidate cell sources for regenerative therapy include embryonic stem cells (created from embryos based on the fertilization of oocytes), induced pluripotent stem cells (created artificially by using somatic cells as the starting material), and somatic stem cells (found in the tissues of the adult body). This review summarizes the identifying features and the therapeutic potential of each of these stem cell types for bone regenerative medicine. Although a number of different kinds of somatic stem cells have been reported, we turn our attention toward two that are of particular interest for prospective applications in bone repair: the dedifferentiated fat cell, and the deciduous dental pulp-derived stem cell.
authors.affiliation: Department of Pathology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan, mikami.yoshikazu@nihon-u.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Mikami
authors.forename: Taro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kano
authors.forename: Taku
authors.initials: T
authors.lastname: Toriumi
authors.forename: Masanori
authors.initials: M
authors.lastname: Somei
authors.forename: Masaki J
authors.initials: MJ
authors.lastname: Honda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001861:Bone Regeneration; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use*; D033581:Stem Cell Transplantation
chemical_list: D050071:Bone Density Conservation Agents; D010281:Parathyroid Hormone