title: Clinicopathological characteristics of incidental prostate cancer discovered from radical cystoprostatectomy specimen: a multicenter French study.
abstract: OBJECTIVE
  The present study assessed the incidence and histopathological features of incidentally diagnosed prostate cancer (PCa) in specimens from radical cystoprostatectomy (RCP) for bladder cancer. The patient outcomes also were evaluated.
  
  
  METHODS
  We retrospectively reviewed the histopathological features and survival data of 4,299 male patients who underwent a RCP for bladder cancer at 25 French centers between January 1996 and June 2012. No patients had preoperative clinical or biological suspicion of PCa.
  
  
  RESULTS
  Among the 4,299 RCP specimens, PCa was diagnosed in 931 patients (21.7%). Most tumors (90.1%) were organ-confined (pT2), whereas 9.9% of them were diagnosed at a locally advanced stage (≥pT3). Gleason score was <6 in 129 cases (13.9%), 6 in 575 cases (61.7%), 7 (3 + 4) in 149 cases (16.0%), 7 (4 + 3) in 38 cases (4.1%), and >7 in 40 cases (4.3%). After a median follow-up of 25.5 months (interquartile range 14.2-47.4), 35.4% of patients had bladder cancer recurrence and 23.8% died of bladder cancer. Only 16 patients (1.9%) experienced PCa biochemical recurrence during follow-up, and no preoperative predictive factor was identified. No patients died from PCa.
  
  
  CONCLUSIONS
  The rate of incidentally diagnosed PCa in RCP specimens was 21.7%. The majority of these PCas were organ-confined. PCa recurrence occurred in only 1.9% of cases during follow-up.
authors.affiliation: Department of Urology, Bicetre Academic Hospital, Paris XI University, Le Kremlin Bicêtre Cedex, France, gg_pignot@yahoo.fr.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Pignot
authors.forename: Laurent
authors.initials: L
authors.lastname: Salomon
authors.forename: Yann
authors.initials: Y
authors.lastname: Neuzillet
authors.forename: Alexandra
authors.initials: A
authors.lastname: Masson-Lecomte
authors.forename: Cédric
authors.initials: C
authors.lastname: Lebacle
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Patard
authors.forename: Pierre
authors.initials: P
authors.lastname: Lunardi
authors.forename: Pascal
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authors.lastname: Rischmann
authors.forename: Gilles
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authors.lastname: Pasticier
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Bernhard
authors.forename: Jérémy
authors.initials: J
authors.lastname: Cohen
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Timsit
authors.forename: Virginie
authors.initials: V
authors.lastname: Verkarre
authors.forename: Benoit
authors.initials: B
authors.lastname: Peyronnet
authors.forename: Gregory
authors.initials: G
authors.lastname: Verhoest
authors.forename: Constance
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authors.lastname: Le Goux
authors.forename: Marc
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authors.lastname: Zerbib
authors.forename: François
authors.initials: F
authors.lastname: Brecheteau
authors.forename: Pierre
authors.initials: P
authors.lastname: Bigot
authors.forename: Stéphane
authors.initials: S
authors.lastname: Larre
authors.forename: Thibault
authors.initials: T
authors.lastname: Murez
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Thuret
authors.forename: Emeric
authors.initials: E
authors.lastname: Lacarriere
authors.forename: Cécile
authors.initials: C
authors.lastname: Champy
authors.forename: Morgan
authors.initials: M
authors.lastname: Roupret
authors.forename: Eva
authors.initials: E
authors.lastname: Comperat
authors.forename: Julien
authors.initials: J
authors.lastname: Berger
authors.forename: Aurélien
authors.initials: A
authors.lastname: Descazeaud
authors.forename: Harry
authors.initials: H
authors.lastname: Toledano
authors.forename: Cyrille
authors.initials: C
authors.lastname: Bastide
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lavilledieu
authors.forename: Christophe
authors.initials: C
authors.lastname: Avances
authors.forename: Francky
authors.initials: F
authors.lastname: Delage
authors.forename: Antoine
authors.initials: A
authors.lastname: Valeri
authors.forename: Benoit
authors.initials: B
authors.lastname: Molimard
authors.forename: Alain
authors.initials: A
authors.lastname: Houlgatte
authors.forename: Pascal
authors.initials: P
authors.lastname: Gres
authors.forename: Alain
authors.initials: A
authors.lastname: Donnaint
authors.forename: François
authors.initials: F
authors.lastname: Kleinclauss
authors.forename: Sophie
authors.initials: S
authors.lastname: Legal
authors.forename: Arnaud
authors.initials: A
authors.lastname: Doerfler
authors.forename: Nicolas
authors.initials: N
authors.lastname: Koutlidis
authors.forename: Luc
authors.initials: L
authors.lastname: Cormier
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Hetet
authors.forename: Philippe
authors.initials: P
authors.lastname: Colls
authors.forename: Alexis
authors.initials: A
authors.lastname: Arvin-Berod
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Rambeaud
authors.forename: Hervé
authors.initials: H
authors.lastname: Quintens
authors.forename: Michel
authors.initials: M
authors.lastname: Soulie
authors.forename: Christian
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authors.lastname: Pfister
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*