title: Phylogenetic Analysis of the Rotavirus Genotypes Originated from Children < 5 Years of Age in 16 Cities in South Korea, between 2000 and 2004.
abstract: OBJECTIVE
  The purpose of this study was to examine the diversity of the G and P types of human rotavirus strains isolated in South Korea during 2000 to 2004.
  
  
  METHODS
  We selected 38 Group A rotavirus isolates among 652 fecal samples, which were collected from infants and children < 5 years of age with acute gastroenteritis or diarrhea admitted in 8 hospitals representative of five provinces of South Korea between 2000 and 2004. Rotavirus P- and G-genotypes were determined by nucleotide sequencing and phylogenetic analysis was performed.
  
  
  RESULTS
  One G1P[4] consisted G1-Id-P[4]-V; one G1P[6] consisted G1-Id-P[6]-Ia; nine G1P[8] consisted G1-Ib-P[8]-Ia (n=3), G1-Ic-P[8]-Ia (n=1), and G1-Id-P[8]-Ia (n=5); 13 G2P[4] consisted G2-V-P[4]-V; two G3P[4] consisted G3-IIId-P[4]-V; five G3P[8] consisted G3-IIId-P[8]-Ia; four G4P[6] consisted G4-Ie-P[6]-Ia; two G4P[8] consisted G4-Ie-P[8]-II; one G9P[6] consisted G9-III-P[6]-Ia.
  
  
  CONCLUSIONS
  A considerable amount of rotavirus genotypic diversity was detected in South Korea from 2000 to 2004. These findings are important to develop the effective vaccines and to undertake epidemiologic studies.
authors.affiliation: National Center for Lot Release, National Institute of Food & Drug Safety Evaluation, Korea Food & Drug Administration, Osong, Korea. ; School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
authors.forename: Ho-Kyung
authors.initials: HK
authors.lastname: Oh
authors.forename: Seung-Hwa
authors.initials: SH
authors.lastname: Hong
authors.forename: Byung-Yoon
authors.initials: BY
authors.lastname: Ahn
authors.forename: Hye-Kyoung
authors.initials: HK
authors.lastname: Min
keywords: South Korea; human rotavirus vaccine; phylogenetic analysis; rotavirus; viral gastroenteritis