title: Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one.
abstract: A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new σ bonds and six stereocenters including a quaternary carbon center in a single operation.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Tuan-Jie
authors.initials: TJ
authors.lastname: Li
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yin
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Yao
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Xiang-Shan
authors.initials: XS
authors.lastname: Wang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Xiu-Ling
authors.initials: XL
authors.lastname: Li
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D007212:Indolizines