title: [Role of Follicular helper CD4 T cells in HIV/SIV infection].
abstract: Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and generation of high affinity memory B cells and plasma cells. There are numerous reports regarding the dysfunction of B cell mediated immune responses, the lack of memory CD4 T cells and the dysfunction of HIV specific CD4 T cells in SIV/HIV infection. During chronic SIV/HIV infection, TFH cell accumulation may drive B cell dysfunction and become a major HIV reservoir. In this review, we discuss the relationship between TFH cells and B cells in SIV/HIV infection.
authors.affiliation: Immunology Laboratory/ Vaccine Research Center/ NIAID/ NIH.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D016915:AIDS Vaccines; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D018858:Germinal Center; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D000882:Haplorhini; D006801:Humans; D007156:Immunologic Memory; D008208:Lymphatic System / Q000276:immunology / Q000821:virology; D009154:Mutation; D018449:SAIDS Vaccines; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D027041:Somatic Hypermutation, Immunoglobulin; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014779:Virus Replication
chemical_list: D016915:AIDS Vaccines; D018449:SAIDS Vaccines