title: Intravenous sildenafil in the management of pulmonary hypertension associated with congenital diaphragmatic hernia.
abstract: BACKGROUND
  Pulmonary artery hypertension (PAH) is a significant cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). The phosphodiesterase-5 inhibitor sildenafil may be beneficial as a pulmonary vasodilator in CDH. Use of oral preparations of sildenafil may be restricted by feeding delays and intolerance. This study assessed the cardiorespiratory effects of a newly available intravenous (IV) preparation of sildenafil in CDH.
  
  
  OBJECTIVE
  The objective of the article is to assess the acute effects of IV sildenafil infusion on myocardial function, pulmonary artery pressure (PAP), and oxygenation in infants with CDH.
  
  
  METHODS
  Retrospective case review of infants with CDH who received continuous IV sildenafil. Physiological and echocardiographic data were reviewed to obtain oxygenation index (OI), PAP, patent ductus arteriosus (PDA) flow, myocardial tissue Doppler velocities, and right ventricular output (RVO) at 48 hours presildenafil, and at 24 to 48 hours and 72 to 96 hours after commencing IV sildenafil.
  
  
  RESULTS
  A total of nine infants received IV sildenafil at a dose of 100 to 290 μg/kg/h after CDH repair but before enteral feeding. Pre-IV sildenafil PAP was ≥ systemic blood pressure in all infants, systolic and diastolic right ventricular myocardial velocities were impaired. After 72 to 96 hours of IV sildenafil, OI and Fio 2 were significantly reduced. Ratio of right-to-left to left-to-right PDA flow was > 1 pre-IV sildenafil and < 1 post-IV sildenafil.
  
  
  CONCLUSIONS
  IV sildenafil infusion was associated with improved oxygenation. Prospective trials of IV sildenafil are required to determine effects on longer term outcome.
authors.affiliation: Newborn Intensive Care, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: Anja
authors.initials: A
authors.lastname: Bialkowski
authors.affiliation: Newborn Intensive Care, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: Florian
authors.initials: F
authors.lastname: Moenkemeyer
authors.affiliation: Newborn Intensive Care, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: Neil
authors.initials: N
authors.lastname: Patel
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010101:Oxygen Consumption; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage*; D011651:Pulmonary Artery / Q000502:physiology; D012189:Retrospective Studies; D000068677:Sildenafil Citrate / Q000008:administration & dosage*; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate