title: Relationship between acute phase proteins and serum fatty acid composition in morbidly obese patients.
abstract: BACKGROUND
  Obesity is considered a low-grade inflammatory state and has been associated with increased acute phase proteins as well as changes in serum fatty acids. Few studies have assessed associations between acute phase proteins and serum fatty acids in morbidly obese patients.
  
  
  OBJECTIVE
  To investigate the relationship between acute phase proteins (C-Reactive Protein, Orosomucoid, and Albumin) and serum fatty acids in morbidly obese patients.
  
  
  METHODS
  Twenty-two morbidly obese patients were enrolled in this study. Biochemical and clinical data were obtained before bariatric surgery, and fatty acids measured in preoperative serum.
  
  
  RESULTS
  Orosomucoid was negatively correlated with lauric acid (P = 0.027) and eicosapentaenoic acid (EPA) (P = 0.037) and positively with arachidonic acid (AA) (P = 0.035), AA/EPA ratio (P = 0.005), and n-6/n-3 polyunsaturated fatty acids ratio (P = 0.035). C-Reactive Protein (CRP) was negatively correlated with lauric acid (P = 0.048), and both CRP and CRP/Albumin ratio were negatively correlated with margaric acid (P = 0.010, P = 0.008, resp.). Albumin was positively correlated with EPA (P = 0.027) and margaric acid (P = 0.008). Other correlations were not statistically significant.
  
  
  CONCLUSIONS
  Our findings suggest that serum fatty acids are linked to acute phase proteins in morbidly obese patients.
authors.affiliation: Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Trindade Campus, 88040-900 Florianópolis, SC, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fernandes
authors.forename: Bruna Teles Soares
authors.initials: BT
authors.lastname: Beserra
authors.forename: Raphael Salles Granato
authors.initials: RS
authors.lastname: Cunha
authors.forename: Elaine
authors.initials: E
authors.lastname: Hillesheim
authors.forename: Carolina de Quadros
authors.initials: Cde Q
authors.lastname: Camargo
authors.forename: Danielle Cristina Tonello
authors.initials: DC
authors.lastname: Pequito
authors.forename: Isabela Coelho
authors.initials: IC
authors.lastname: de Castro
authors.forename: Luiz Cláudio
authors.initials: LC
authors.lastname: Fernandes
authors.forename: Everson Araújo
authors.initials: EA
authors.lastname: Nunes
authors.forename: Erasmo Benício Santos de Moraes
authors.initials: EB
authors.lastname: Trindade
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D006801:Humans; D007850:Lauric Acids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D007850:Lauric Acids; C030358:lauric acid