title: The role of calprotectin in pediatric disease.
abstract: Calprotectin (CP) is a calcium- and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. The aim of the current review is to summarize the latest findings concerning the role of CP in a diverse range of inflammatory and noninflammatory conditions among children. Increasing evidence suggests the implication of CP in the diagnosis, followup, assessment of relapses, and response to treatment in pediatric pathological conditions, such as inflammatory bowel disease, necrotizing enterocolitis, celiac disease, intestinal cystic fibrosis, acute appendicitis, juvenile idiopathic arthritis, Kawasaki disease, polymyositis-dermatomyositis, glomerulonephritis, IgA nephropathy, malaria, HIV infection, hyperzincemia and hypercalprotectinemia, and cancer. Further studies are required to provide insights into the actual role of CP in these pathological processes in pediatrics.
authors.affiliation: Department of Pediatric Surgery, Alexandroupolis University Hospital, Democritus University of Thrace School of Medicine, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Vaos
authors.forename: Ioannis D
authors.initials: ID
authors.lastname: Kostakis
authors.forename: Nick
authors.initials: N
authors.lastname: Zavras
authors.forename: Athanasios
authors.initials: A
authors.lastname: Chatzemichael
mesh_terms: D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007249:Inflammation / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D039841:Leukocyte L1 Antigen Complex / Q000235:genetics* / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010372:Pediatrics
chemical_list: D002352:Carrier Proteins; D039841:Leukocyte L1 Antigen Complex; C017800:zinc-binding protein; D002118:Calcium