title: Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction.
abstract: OBJECTIVE
  The objective of this study is to investigate endothelial dysfunction (ED) and arterial stiffness (AS) and determine the association with diastolic dysfunction in children with type 1 diabetes mellitus (DM).
  
  
  METHODS
  A total of 42 patients without diabetic complications (mean age: 13.21 years) and 40 healthy (mean age: 13.07 years) children were included in this study. AS was assessed with ascending aorta M-mode measurements, diastolic dysfunction with pulsed wave (PW) Doppler and tissue Doppler echocardiography measurements and flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT) with high-resolution ultrasonography.
  
  
  RESULTS
  Results of diabetic group and healthy children were compared. In diabetic group, aortic strain (8.40 ± 2.98, 20.12 ± 5.04; p < 0.001), aortic distensibility (7.36 ± 2.92, 16.59 ± 4.25; p < 0.001) and FMD% (7.70 ± 2.83, 11.33 ± 2.85; p < 0.001) were found decreased, and CIMT (0.52 ± 0.09 mm, 0.47 ± 0.08 mm; p < 0.05) was found increased. Additionally, left ventricular lateral segment and right ventricular free-wall isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were found increased. Correlation analyses demonstrated a negative correlation between FMD and IVRT and MPI.
  
  
  CONCLUSIONS
  ED and AS were found in type 1 DM patients without diabetic complications. Additionally, correlation was shown between increased AS and ED and right and left ventricular diastolic dysfunctions.
authors.affiliation: Department of Pediatric Cardiology, Akdeniz University Medical Faculty, Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çiftel
authors.forename: Halil
authors.initials: H
authors.lastname: Ertuğ
authors.forename: Mesut
authors.initials: M
authors.lastname: Parlak
authors.forename: Gayaz
authors.initials: G
authors.lastname: Akçurin
authors.forename: Firat
authors.initials: F
authors.lastname: Kardelen
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D015415:Biomarkers; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000150:complications / Q000000981:diagnostic imaging*; D058065:Diabetic Cardiomyopathies / Q000150:complications / Q000000981:diagnostic imaging*; D042241:Early Diagnosis; D015150:Echocardiography, Doppler; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D018617:Ultrasonography, Doppler, Pulsed; D059289:Vascular Stiffness; D018754:Ventricular Dysfunction / Q000150:complications / Q000000981:diagnostic imaging*
chemical_list: D015415:Biomarkers
keywords: Type 1 diabetes mellitus; arterial stiffness; diastolic dysfunction; endothelial dysfunction