title: [Cartilage regeneration using cell reprogramming technologies].
abstract: Injuries to articular cartilage do not heal spontaneously, and when left untreated, result in the diffuse degeneration of cartilage. Autologous chondrocyte transplantation has been performed to treat focal articular cartilage defects, but the repaired tissue includes fibrous tissue. Healing with hyaline cartilage has been difficult to achieve. The generation of induced pluripotent stem (iPS) cells has enabled us to rejuvenate somatic cells and provide them with pluripotency. This technology may contribute to producing hyaline cartilage. In addition, fibroblasts can be converted toward chondrogenic cells by directed reprogramming technology. Research aimed at the realization of cartilage regeneration using cell reprogramming technologies is underway.
authors.affiliation: Dept. of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tsumaki
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D051457:Hyaline Cartilage / Q000166:cytology* / Q000502:physiology*; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology*; D051379:Mice; D053652:Nuclear Transfer Techniques; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*