title: Validation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios.
abstract: An aortic dissection (AD) is a serious condition defined by the splitting of the arterial wall, thus generating a secondary lumen [the false lumen (FL)]. Its management, treatment and follow-up are clinical challenges due to the progressive aortic dilatation and potentially severe complications during follow-up. It is well known that the direction and rate of dilatation of the artery wall depend on haemodynamic parameters such as the local velocity profiles, intra-luminal pressures and resultant wall stresses. These factors act on the FL and true lumen, triggering remodelling and clinical worsening. In this study, we aimed to validate a computational fluid dynamic (CFD) tool for the haemodynamic characterisation of chronic (type B) ADs. We validated the numerical results, for several dissection geometries, with experimental data obtained from a previous in vitro study performed on idealised dissected physical models. We found a good correlation between CFD simulations and experimental measurements as long as the tear size was large enough so that the effect of the wall compliance was negligible.
authors.affiliation: a Department of Biomedical Engineering , International Center for Numerical Methods in Engineering (CIMNE), Universitat Politècnica de Catalunya , Barcelona , Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Soudah
authors.forename: Paula
authors.initials: P
authors.lastname: Rudenick
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bordone
authors.forename: Bart
authors.initials: B
authors.lastname: Bijnens
authors.forename: David
authors.initials: D
authors.lastname: García-Dorado
authors.forename: Arturo
authors.initials: A
authors.lastname: Evangelista
authors.forename: Eugenio
authors.initials: E
authors.lastname: Oñate
mesh_terms: D000784:Aortic Dissection / Q000473:pathology*; D001014:Aortic Aneurysm / Q000473:pathology*; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging
keywords: aortic diseases; aortic dissection; computational fluid dynamics; in vitro phantoms