title: Cyclophilin-A: a novel biomarker for untreated male essential hypertension.
abstract: Vascular cytokines, total nitrite, and cyclophilin-A (CyP-A) may be related to the pathogenesis of untreated hypertension. Forty males with normotensive and untreated essential hypertension were recruited in this cytokines survey. Body mass index (BMI), hyperlipidemia, and plasma CyP-A were increased in the hypertensive group (p < 0.05). However, only BMI (p = 0.022) and plasma CyP-A (p = 0.020) were found to be significant contributors to hypertension by multiple regression analysis. CyP-A was also positively correlated with systolic blood pressure (p = 0.029) and diastolic blood pressure (p = 0.047). These findings indicated that plasma CyP-A is a critical molecular biomarker in the early pathogenesis of essential hypertension.
authors.affiliation: Department of Neurology, Changhua Christian Hospital , Changhua , Taiwan .
authors.forename: Chen-Shu
authors.initials: CS
authors.lastname: Chang
authors.forename: Shih-Li
authors.initials: SL
authors.lastname: Su
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Chang
authors.forename: Kwo-Whei
authors.initials: KW
authors.lastname: Lee
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Kuo
authors.forename: Ching-Shan
authors.initials: CS
authors.lastname: Huang
authors.forename: Wan-Min
authors.initials: WM
authors.lastname: Tseng
authors.forename: Chin-San
authors.initials: CS
authors.lastname: Liu
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D021984:Cyclophilin A / Q000097:blood*; D016207:Cytokines / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D016207:Cytokines; D021984:Cyclophilin A