title: Associations between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and risk of differentiated thyroid carcinoma: a meta-analysis.
abstract: BACKGROUND
  Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory.
  
  
  METHODS
  We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively.
  
  
  RESULTS
  No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province and Ministry of Health, Harbin, China E-mail : hrbmusdj@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Han
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Gao
authors.forename: Dian-Jun
authors.initials: DJ
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000209:etiology*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human