title: Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin.
authors.affiliation: QB3 Institute, University of California, Berkeley, CA, USA.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yuzawa
authors.affiliation: 1] QB3 Institute, University of California, Berkeley, CA, USA [2] Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA [3] Synthetic Biology Engineering Research Center, Emeryville, CA, USA.
authors.forename: Clara H
authors.initials: CH
authors.lastname: Eng
authors.affiliation: 1] QB3 Institute, University of California, Berkeley, CA, USA [2] Synthetic Biology Engineering Research Center, Emeryville, CA, USA.
authors.forename: Leonard
authors.initials: L
authors.lastname: Katz
authors.affiliation: 1] QB3 Institute, University of California, Berkeley, CA, USA [2] Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA [3] Synthetic Biology Engineering Research Center, Emeryville, CA, USA [4] Department of Bioengineering, University of California, Berkeley, CA, USA [5] Joint BioEnergy Institute, Emeryville, CA, USA [6] Lawrence Berkeley National Laboratory, Physical Bioscience Division, Berkeley, CA, USA.
authors.forename: Jay D
authors.initials: JD
authors.lastname: Keasling
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D055808:Drug Discovery; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D048630:Polyketide Synthases / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D013304:Streptomyces aureofaciens / Q000201:enzymology / Q000378:metabolism*
chemical_list: D006027:Glycosides; D011090:Polyenes; C548829:alpha-lipomycin; D048630:Polyketide Synthases