title: International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV): content and implementation in daily routine practice.
abstract: Over the past decades major improvements in the management of chemotherapy induced nausea and vomiting (CINV) were obtained. With the correct use of antiemetic drugs, CINV can be prevented in almost 70%, and even up to, 80% of patients. Treatment guidelines enable physicians to integrate the latest clinical research into their daily practice. The large volume of rapidly evolving clinical data has been summarised and incorporated into treatment recommendations by well-known and reliable institutions. These organisations include the Multinational Association of Supportive Care in Cancer (MASCC), the European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), and National Comprehensive Cancer Network (NCCN). However, despite the availability of these guidelines, there is an emerging evidence that adherence to, and implementation of, treatment recommendations is less than optimal. This review will especially focus on the content of the current antiemetic guidelines and will address the important question of how these guidelines are implemented in routine practice.
authors.affiliation: Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle/Wittenberg, Ernst-Grube-Straße 40, 06120 Halle/Saale, Germany. Electronic address: Karin.jordan@uk-halle.de.
authors.forename: Karin
authors.initials: K
authors.lastname: Jordan
authors.affiliation: Department of Medicine Director, Oncology Research for the North Bronx Healthcare Network Albert Einstein college of Medicine New York, NY.
authors.forename: Richard
authors.initials: R
authors.lastname: Gralla
authors.affiliation: Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle/Wittenberg, Ernst-Grube-Straße 40, 06120 Halle/Saale, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Jahn
authors.affiliation: School of Nursing & WHO Collaborating Centre for Community Health Services, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Alex
authors.initials: A
authors.lastname: Molassiotis
mesh_terms: D000932:Antiemetics / Q000494:pharmacology*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D038622:Internationality; D009325:Nausea / Q000139:chemically induced* / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000932:Antiemetics
keywords: 5-HT(3) serotonin receptor antagonists; ASCO antiemetic guidelines; Antiemetic therapy; MASCC/ESMO antiemetic guidelines; NCCN practice antiemesis guidelines; Neurokinin(1) receptor antagonist