title: Prediction of all-cause mortality from gated-SPECT global myocardial wall thickening: comparison with ejection fraction and global longitudinal 2D-strain.
abstract: BACKGROUND
  The aim of this study was to assess the correlation between global wall thickening (GWT) obtained by gated-single photon emission computed tomography (SPECT) and echocardiographic measures [ejection fraction (EF), global longitudinal strain (GLS), and strain rate (GLSR)] and to compare their prognostic value for all-cause mortality.
  
  
  RESULTS
  Seventy-four patients with referral for dipyridamole myocardial perfusion SPECT were prospectively included and underwent transthoracic echocardiography to measure left ventricular EF, GLS, and GLSR. The strongest correlation with GWT was for EF (R = 0.63, P < .001), followed by GLSR (R = -0.57, P < .001) and GLS (R = -0.53, P < .001). There were ten deaths over a period of 14.6 ± 5.7 months. Using the multivariate Cox analysis, summed stress score (HR 1.108; P = .023), EF (HR 1.01, P = .031), GLS (HR 1.593, P = .001), and GWT (HR 0.898, P = .034) remained independent predictors of mortality. Mean survival rate evaluated by Kaplan-Meier analysis was longer in patients with GWT ≥ 24% (21.9 ± 0.6 months) than those with GWT < 24% (13.6 ± 2.7 months; P < .001).
  
  
  CONCLUSIONS
  GWT assessed is a highly sensitive tool to detect early myocardial systolic dysfunction and may bring additional prognostic information.
authors.affiliation: Department of Nuclear Medicine, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France, lairez@gmail.com.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lairez
authors.forename: Thomas
authors.initials: T
authors.lastname: Cognet
authors.forename: Laurent
authors.initials: L
authors.lastname: Dercle
authors.forename: Simon
authors.initials: S
authors.lastname: Méjean
authors.forename: Matthieu
authors.initials: M
authors.lastname: Berry
authors.forename: Delphine
authors.initials: D
authors.lastname: Bastié
authors.forename: Rainui
authors.initials: R
authors.lastname: Richaud
authors.forename: Matthieu
authors.initials: M
authors.lastname: Gautier
authors.forename: Audrey
authors.initials: A
authors.lastname: Fouilloux
authors.forename: Michel
authors.initials: M
authors.lastname: Galinier
authors.forename: Didier
authors.initials: D
authors.lastname: Carrié
authors.forename: Pierre
authors.initials: P
authors.lastname: Massabuau
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berry
mesh_terms: D000368:Aged; D019540:Area Under Curve; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000401:mortality; D004176:Dipyridamole / Q000737:chemistry; D004452:Echocardiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009206:Myocardium / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000401:mortality; D016277:Ventricular Function, Left
chemical_list: D004176:Dipyridamole