title: Pandemic influenza A (H1N1) in non-vaccinated, pregnant women in Spain (2009-2010).
abstract: The aim of this study was to investigate the main characteristics of non-vaccinated pregnant women who were hospitalised for influenza A (H1N1) pdm09 pandemic versus pregnant women hospitalised for non-influenza-related reasons in Spain, and to characterise the clinical presentation of the disease in this population to facilitate early diagnosis and future action programmes. Understanding influenza infection during pregnancy is important as pregnant women are a high-risk population for increased morbidity from influenza infection. We investigated the socio-demographic and clinical features of 51 non-vaccinated, pregnant women infected with the pandemic influenza A (H1N1) virus in Spain (cases) and compared them to 114 controls (non-vaccinated and non-infected pregnant women) aged 15-44 years. Substantial and significant odd ratios (ORs) for pandemic influenza A (H1N1) were found for the pregnant women who were obese compared with controls (body mass index > 30) (OR 3.03; 95% confidence intervals 1.13-8.11). The more prevalent symptoms observed in pandemic influenza-infected pregnant women were high temperature, cough (82.4%), malaise (80.5%), myalgia (56.1%), and headaches (54.9%). Our results suggest that the initial symptoms and risk factors for infection of pregnant women with the influenza A (H1N1) pdm09 virus are similar to the symptoms and risk factors for seasonal influenza, which make early diagnosis difficult, and reinforces the need to identify and protect high-risk groups.
authors.affiliation: Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Avda. Vicent Andrés Estellés, s/n, 46100, Burjassot, Valencia, Spain, maria.m.morales@uv.es.
authors.forename: María
authors.initials: M
authors.lastname: Morales-Suárez-Varela
authors.forename: Fernando
authors.initials: F
authors.lastname: González-Candelas
authors.forename: Jenaro
authors.initials: J
authors.lastname: Astray
authors.forename: Jordi
authors.initials: J
authors.lastname: Alonso
authors.forename: Ady
authors.initials: A
authors.lastname: Castro
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Galán
authors.forename: Olatz
authors.initials: O
authors.lastname: Garin
authors.forename: Núria
authors.initials: N
authors.lastname: Soldevila
authors.forename: Maretva
authors.initials: M
authors.lastname: Baricot
authors.forename: Jesús
authors.initials: J
authors.lastname: Castilla
authors.forename: Pere
authors.initials: P
authors.lastname: Godoy
authors.forename: Miguel
authors.initials: M
authors.lastname: Delgado-Rodríguez
authors.forename: Vicente
authors.initials: V
authors.lastname: Martín
authors.forename: José María
authors.initials: JM
authors.lastname: Mayoral
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: José Maria
authors.initials: JM
authors.lastname: Quintana
authors.forename: Sonia
authors.initials: S
authors.lastname: Tamames
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
authors.forename: Angela
authors.initials: A
authors.lastname: Domínguez
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines / Q000627:therapeutic use; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control; D058873:Pandemics / Q000706:statistics & numerical data*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines