title: The many flavors of tumor-associated B cells.
abstract: Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neoplastic lesions. Here we discuss the role of B lymphocytes as antigen-presenting cells and catalysts of T cell-based immunotherapies in view of these findings.
authors.affiliation: Department of Medicine; Unit of Translational Immunology; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Marits
authors.forename: Ali A
authors.initials: AA
authors.lastname: Zirakzadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Sherif
authors.forename: Ola
authors.initials: O
authors.lastname: Winqvist
keywords: B-cell subtypes; adoptive immunotherapy; antigen-presenting cell; clonal expansion; tumor-draining lymph nodes