title: High nasal burden of methicillin-resistant Staphylococcus aureus increases risk of invasive disease.
abstract: In a retrospective cohort study of 1,140 patients harboring methicillin-resistant Staphylococcus aureus, the nasal burden was low in 31%, category 1+ to 2+ in 54%, and category 3+ to 4+ in 15%. There was a significant trend in infection risk with increasing nasal burden (P = 0.007). In multivariate models, high nasal burden remained significantly associated with invasive infection.
authors.affiliation: Health Policy Research Institute, University of California Irvine School of Medicine, Irvine, California, USA.
authors.forename: Rupak
authors.initials: R
authors.lastname: Datta
authors.forename: Atia
authors.initials: A
authors.lastname: Shah
authors.forename: Susan S
authors.initials: SS
authors.lastname: Huang
authors.forename: Eric
authors.initials: E
authors.lastname: Cui
authors.forename: Vinh
authors.initials: V
authors.lastname: Nguyen
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Welbourne
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Quan
authors.forename: Lauri
authors.initials: L
authors.lastname: Thrupp
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058491:Bacterial Load; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D055815:Young Adult