title: Age-related changes in trabecular meshwork imaging.
abstract: OBJECTIVE
  To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images.
  
  
  METHODS
  One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length, and area and length of the TM interface shadow from 3 age groups (18-40, 41-60, and 61-80). Measurements were compared using stepwise regression analysis.
  
  
  RESULTS
  The average TM parameters were 0.0487 (± 0.0092) mm(2) for TM area, 0.5502 (± 0.1033) mm for TM length, 0.1623 (± 0.341) mm(2) for TM interface shadow area, and 0.7755 (± 0.1574) mm for TM interface shadow length. Interobserver reproducibility coefficients ranged from 0.45 (TM length) to 0.82 (TM area). TM area and length were not correlated with age. While the TM interface shadow length did not correlate with age, the TM interface shadow area increased with age. Race, sex, intraocular pressure, and gonioscopy score were not correlated with any TM parameters.
  
  
  CONCLUSIONS
  Although the TM measurements were not correlated with age, the TM interface shadow area increased with age. Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function.
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, 6431 Fannin Street, MSB 7.024, Houston, TX 77030, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Gold
authors.forename: Seema
authors.initials: S
authors.lastname: Kansara
authors.forename: Kundandeep S
authors.initials: KS
authors.lastname: Nagi
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Bell
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Blieden
authors.forename: Alice Z
authors.initials: AZ
authors.lastname: Chuang
authors.forename: Laura A
authors.initials: LA
authors.lastname: Baker
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Mankiewicz
authors.forename: Robert M
authors.initials: RM
authors.lastname: Feldman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000869:Anterior Eye Segment / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012984:Software; D041623:Tomography, Optical Coherence / Q000379:methods*; D014129:Trabecular Meshwork / Q000473:pathology*; D055815:Young Adult