title: A clinical comparison of safety and efficacy in phacoemulsification with versus without ophthalmic viscoelastic device.
abstract: OBJECTIVE
  To evaluate in a comparative manner the safety and efficacy of 1.0% sodium-Hyaluronate used during capsulorhexis and intraocular lens (IOL) implantation in phacoemulsification surgery.
  
  
  METHODS
  1.0% sodium-Hyaluronate, which is commonly used as one of the ophthalmic viscoelastic devices, was compared to intraocular irrigating solution, which can bring up these effects. In addition, the effect of both methods on occurring corneal endothelial cell (CEC) loss was investigated.
  
  
  RESULTS
  Each group comprised 19 eyes. The mean preoperative CEC density was 2525.68 ± 181.85 in Group H and 2514.16 ± 174.59 in Group V; no statistically significant difference was found between the groups (p > 0.05). Preoperative and postoperative first and twelfth week CEC densities were 2438.21 ± 198.12 (p < 0.001) and 2390.74 ± 202.31, respectively, in group H (p < 0.001). Preoperative and postoperative first and twelfth week CEC densities were 2415.32 ± 197.24 (p < 0.001) and 2353.47 ± 212.69 in group V (p < 0.001). Compared with preoperative values, decrease in CEC density on the postoperative first and twelfth weeks was not statistically significant in either group (p > 0.05).
  
  
  CONCLUSIONS
  Although it was found that there was no statistically difference in terms of preventing CEC loss between 1.0% sodium-Hyaluronate and the irrigation method during phacoemulsification, it was observed clinically that 1.0% sodium-hyaluronate can make the procedure easy, safer, very helpful, especially for understanding phacoemulsification.
authors.affiliation: Dr. Lutfi Kırdar Kartal Training and Research Hospital, Eye Clinic , Istanbul , Turkey .
authors.forename: Suleyman
authors.initials: S
authors.lastname: Kugu
authors.forename: Gurkan
authors.initials: G
authors.lastname: Erdogan
authors.forename: M
authors.initials: M
authors.lastname: Sahin Sevim
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozerturk
mesh_terms: D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000503:physiopathology*; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D055675:Viscosupplements / Q000008:administration & dosage* / Q000009:adverse effects; D014792:Visual Acuity / Q000502:physiology
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: Corneal endothelial cell; intraocular irrigating solution; ophthalmic viscoelastic device; phacoemulsification; sodium-Hyaluronate