title: Body mass index as a predictive factor of periodontal therapy outcomes.
abstract: Body mass index (BMI) and obesity are associated with the prevalence, extent, and severity of periodontitis. This study investigated the predictive role of overweight/obesity on clinical response following non-surgical periodontal therapy in patients with severe periodontitis. Two hundred sixty adults received an intensive course of non-surgical periodontal therapy. Periodontal status at baseline and 2 months was based upon probing pocket depths (PPD), clinical attachment levels (CAL), and whole-mouth gingival bleeding (FMBS) as assessed by two calibrated examiners. Generalized estimating equations (GEE) were used to estimate the impact of BMI and overweight/obesity on periodontal treatment response while controlling for baseline status, age, smoking status (smoker or non-smoker), and full-mouth dental plaque score. BMI (continuous variable) and obesity (vs. normal weight) were associated with worse mean PPD (p < .005), percentage of PPD > 4 mm (p = .01), but not with FMBS (p > .05) or CAL (p > .05) at 2 months, independent of age, smoking status, or dental plaque levels. The magnitude of this association was similar to that of smoking, which was also linked to a worse clinical periodontal outcome (p < .01). BMI and obesity appear to be independent predictors of poor response following non-surgical periodontal therapy.
authors.affiliation: Unit of Periodontology, UCL, Eastman Dental Institute, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Suvan
authors.forename: A
authors.initials: A
authors.lastname: Petrie
authors.forename: D R
authors.initials: DR
authors.lastname: Moles
authors.forename: L
authors.initials: L
authors.lastname: Nibali
authors.forename: K
authors.initials: K
authors.lastname: Patel
authors.forename: U
authors.initials: U
authors.lastname: Darbar
authors.forename: N
authors.initials: N
authors.lastname: Donos
authors.forename: M
authors.initials: M
authors.lastname: Tonetti
authors.forename: F
authors.initials: F
authors.lastname: D'Aiuto
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005884:Gingival Hemorrhage / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D017622:Periodontal Attachment Loss / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D012907:Smoking; D016896:Treatment Outcome
keywords: chronic disease; obesity; overweight; periodontitis; prognosis; wound healing