title: On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes.
abstract: Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed.
authors.affiliation: Departamento de Química Inorgánica and Regional Campus of International Excellence (Campus Mare Nostrum), Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria, Murcia, Spain. jruiz@um.es.
authors.forename: Gorakh S
authors.initials: GS
authors.lastname: Yellol
authors.forename: Antonio
authors.initials: A
authors.lastname: Donaire
authors.forename: Jyoti G
authors.initials: JG
authors.lastname: Yellol
authors.forename: Vera
authors.initials: V
authors.lastname: Vasylyeva
authors.forename: Christoph
authors.initials: C
authors.lastname: Janiak
authors.forename: José
authors.initials: J
authors.lastname: Ruiz
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006801:Humans; D007495:Iridium / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D056831:Coordination Complexes; D012709:Serum Albumin; D007495:Iridium; D012428:Ruthenium; D004247:DNA; D012238:Rhodium