title: Reigoselective arylation of thiazole derivatives at 5-position via Pd catalysis under ligand-free conditions.
abstract: An efficient regioselective arylation of thiazole derivatives via Pd-catalyzed C-H activation is reported. The transformation was hypothesized through a Pd(0/II) catalytic cycle in the absence of special ligand sets. This method provided an efficient process to direct arylation of thiazoles at the 5-position.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China, State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China, College of Chemistry and Material Chemistry, Sichuan Normal University , Sichuan 610066, China, and DSM Nutritional Products, DSM Nutrition Center, DSM (China) Limited , No. 476 Li Bing Road, Zhangjiang Hi-tech Park, Pudong new area, Shanghai, 201203, China.
authors.forename: Xiang-Wei
authors.initials: XW
authors.lastname: Liu
authors.forename: Jiang-Ling
authors.initials: JL
authors.lastname: Shi
authors.forename: Jia-Xuan
authors.initials: JX
authors.lastname: Yan
authors.forename: Jiang-Bo
authors.initials: JB
authors.lastname: Wei
authors.forename: Kun
authors.initials: K
authors.lastname: Peng
authors.forename: Le
authors.initials: L
authors.lastname: Dai
authors.forename: Chen-Guang
authors.initials: CG
authors.lastname: Li
authors.forename: Bi-Qin
authors.initials: BQ
authors.lastname: Wang
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D008024:Ligands; D013844:Thiazoles; D010165:Palladium