title: Status of stem cell based clinical trials in the treatment for diabetes.
abstract: Rapidly increasing number of diabetic patients across the world is a great challenge to the current therapeutic approach. Although the traditional method of rendering exogenous insulin is an established method of treatment, it is not sufficient and often causes lethal hypoglycemia. There is also a good amount of success with whole organ transplantation or Islet cells' transplantation. But this technique is limited with regards the availability of donors. Currently, many clinicians and researchers are involved in clinical studies using various different stem cells from embryonic as well as adult sources for the treatment of diabetes. In this review we have tried to discuss the results of various clinical trials using stem cells. We have also tried to look at various stem cell types and the routes of injections that are currently being followed world wide.
authors.affiliation: Reliance Life Sciences Pvt Ltd., Dhirubhai Ambani Life Sciences Centre, R/282, MIDC area of TTC, Thane Belapur Road, Rabale, Navi Mumbai 400701, India. chandra.viswanathan@ril.com.
authors.forename: Chandra
authors.initials: C
authors.lastname: Viswanathan
authors.forename: Shabari
authors.initials: S
authors.lastname: Sarang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D053595:Embryonic Stem Cells / Q000637:transplantation*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D015994:Incidence; D050417:Insulin-Secreting Cells / Q000637:transplantation*; D016381:Islets of Langerhans Transplantation; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D051381:Rats; D057905:Stem Cell Research; D033581:Stem Cell Transplantation
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents