title: Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study.
abstract: To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P < 0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P < 0.001). IGFBP-2 did not correlate with age (P = 0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P < 0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, TN, Tennessee.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Borinstein
authors.forename: Donald A
authors.initials: DA
authors.lastname: Barkauskas
authors.forename: Mark
authors.initials: M
authors.lastname: Bernstein
authors.forename: Allen
authors.initials: A
authors.lastname: Goorin
authors.forename: Richard
authors.initials: R
authors.lastname: Gorlick
authors.forename: Mark
authors.initials: M
authors.lastname: Krailo
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Schwartz
authors.forename: Leonard H
authors.initials: LH
authors.lastname: Wexler
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Toretsky
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012516:Osteosarcoma / Q000097:blood* / Q000188:drug therapy / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C577903:IGFBP2 protein, human; C515497:IGFBP3 protein, human; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: cancer biology; clinical trials; osteosarcoma