title: Ribonucleic acid interference induced gene knockdown.
abstract: Despite major advances in periodontal regeneration over the past three decades, complete regeneration of the lost periodontium on a regular and predictable basis in humans has still remained elusive. The identification of stem cells in the periodontal ligament together with the growing concept of tissue engineering has opened new vistas in periodontal regenerative medicine. In this regard, ribonucleic acid interference (RNAi) opens a new gate way for a novel RNA based approach in periodontal management. This paper aims to summarize the current opinion on the mechanisms underlying RNAi, in vitro and in vivo existing applications in the dental research, which could lead to their future use in periodontal regeneration.
authors.affiliation: Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
authors.forename: Sruthima N V S
authors.initials: SN
authors.lastname: Gottumukkala
authors.forename: C D
authors.initials: CD
authors.lastname: Dwarakanath
authors.forename: Sabitha
authors.initials: S
authors.lastname: Sudarsan
keywords: Gene knock down; periodontal regeneration; ribonucleic acid interference; small interfering ribonucleic acid