title: Stem cell transplantation for neuroprotection in stroke.
abstract: Stem cell-based therapies for stroke have expanded substantially over the last decade. The diversity of embryonic and adult tissue sources provides researchers with the ability to harvest an ample supply of stem cells. However, the optimal conditions of stem cell use are still being determined. Along this line of the need for optimization studies, we discuss studies that demonstrate effective dose, timing, and route of stem cells. We recognize that stem cell derivations also provide uniquely individual difficulties and limitations in their therapeutic applications. This review will outline the current knowledge, including benefits and challenges, of the many current sources of stem cells for stroke therapy.
authors.affiliation: Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shinozuka
authors.forename: Travis
authors.initials: T
authors.lastname: Dailey
authors.forename: Naoki
authors.initials: N
authors.lastname: Tajiri
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
keywords: cerebral ischemia; stem cells; stroke; transplantation