title: Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones.
abstract: An asymmetric organocatalysed decarboxylative protonation reaction allowed a straightforward synthesis of α-substituted isoxazolidin-5-ones from readily available 5-substituted Meldrum's acids. This process is initiated by an anionic formal (3+2) cycloaddition-fragmentation, generated in-situ from a sulfone-amide precursor which also served as a latent source of proton.
authors.affiliation: Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan cedex, France. jean-francois.briere@insa-rouen.fr.
authors.forename: Tony
authors.initials: T
authors.lastname: Tite
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sabbah
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Brière