title: Evaluation of the Antibacterial efficacy of Omeprazole with Sodium Hypochlorite as an Endodontic Irrigating Solution- An Invivo Study.
abstract: BACKGROUND
  Proton pump inhibitors are used in endodontic disinfection of root canals for elimination of enterococcus faecalis. This invivo study on Wistner Rats is carried out to determine antimicrobial efficacy of proton pump inhibitor in combination with sodium hypochlorite & Mixture of Isomer of tetracycline, acid and detergent (MTAD) against E. Faecalis Materials & Methods: Periapical lesions were induced on the 30 Incisor teeth of 30 male Wistner rats (10per group). After 28 days, root canals of each tooth were instrumented to 35# k file, during the process of instrumentation canals were irrigated with their respective irrigation solutions. Group-1: 2% CHX + 5.2% NaOCL, Group-2: MTAD(Dentsply Tulsa Dental, Tulsa, OK) + 5.2% NaOCL, Group-3: 8.5% Omeprazole (Dr Reddy's labs private limited - Hyderabad) + 5.2% NaOCL. Microbiological samples were collected by using #35 sterilized paper points after 28 days of inducing periapical lesions, Sample (S1) was collected before instrumentation and Sample (S2) was collected after instrumentation and Irrigation data were subjected to analysis of variance, followed by Newman Keuls Post Hoc test.
  
  
  RESULTS
  Microbiological Analysis revealed significant decrease of colony forming units from S1 to S2 Samples in all the 3 groups.
  
  
  CONCLUSIONS
  Our data showed that association of Omeprazole with NaOCL showed a superior antibacterial efficacy against Enterococcus faecalis in comparision with other irrigants. Key words: Sodium Hypochlorite, Chlorhexidine, Gluconate, MTAD, Omeprazole.
authors.affiliation: Department of Conservative Dentistry & Endodontics, SVS Institute of Dental Sciences, Andhra Pradesh, India.
authors.forename: Padma
authors.initials: P
authors.lastname: Gandi
authors.forename: Sravanthi Rajah
authors.initials: SR
authors.lastname: Vasireddi
authors.forename: Sindhura Reddy
authors.initials: SR
authors.lastname: Gurram
authors.forename: Kishore
authors.initials: K
authors.lastname: Darasani