title: Inflammation and atherosclerosis--revisited.
abstract: Atherogenesis has been traditionally viewed as a metabolic disease representing arterial obstruction by fatty deposits in its wall. Today, it is believed that atherogenesis involves highly specific biochemical and molecular responses with constant interactions between various cellular players. Despite the presence of inflammatory reaction in each and every step of atherosclerosis from its inception to terminal manifestation, the cause--effect relationship of these 2 processes remains unclear. In this article, we have attempted to review the role of inflammation in the development of atherosclerosis and in its major complication--coronary heart disease.
authors.affiliation: 1Department of Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.
authors.forename: Sadip
authors.initials: S
authors.lastname: Pant
authors.forename: Abhishek
authors.initials: A
authors.lastname: Deshmukh
authors.forename: Guru S
authors.initials: GS
authors.lastname: Gurumurthy
authors.forename: Naga Venkata
authors.initials: NV
authors.lastname: Pothineni
authors.forename: Thomas Evans
authors.initials: TE
authors.lastname: Watts
authors.forename: Francesco
authors.initials: F
authors.lastname: Romeo
authors.forename: Jawahar L
authors.initials: JL
authors.lastname: Mehta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators
keywords: atherogenesis; atherosclerosis; coronary artery disease; inflammation