title: Synthesis of symmetric disulfides as potential alternative substrates for trypanothione reductase and glutathione reductase: Part 1.
abstract: The synthesis of a series of symmetrical disulfides as potential substrates of trypanothione reductase and glutathione reductase was described. The key intermediate in the synthetic approach was the choice of S-(t)butylmercapto-L-cysteine (1). The spermidine ring in the native substrate, trypanothione disulfide (TSST), was replaced with 3-dimethyl-aminopropylamine (DMAPA), while theγ-Glu moiety was replaced by phenylalanyl or tryptophanyl residues. The same modifications in theγ-Glu moiety of glutathione disulfide (GSSG) were applied.
authors.affiliation: Pharmacy Department, University of Manchester, Manchester, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Jaouhari
authors.forename: T
authors.initials: T
authors.lastname: Besheya
authors.forename: J H
authors.initials: JH
authors.lastname: McKie
authors.forename: K T
authors.initials: KT
authors.lastname: Douglas