title: Microsatellite instability in hematological malignancies: Hypermutation vs. immune control-who is challenging who?
abstract: The genome of colorectal carcinomas displaying pronounced microsatellite instability codes for an extraordinarily high number of mutated proteins that elicit tumor-specific cellular immune responses. We have recently demonstrated that leukemic cells are also vulnerable to T cells specific for tumor-associated antigens produced in the context of microsatellite instability. This finding extends our understanding of secondary and therapy-related leukemogenesis, linking it to the mutual interaction between immune control and escape.
authors.affiliation: Molecular Oncology and Immunotherapy; Department of General Surgery; University of Rostock; Rostock, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Maletzki
authors.forename: Saskia
authors.initials: S
authors.lastname: Stier
authors.forename: Michael
authors.initials: M
authors.lastname: Linnebacher
keywords: immunosurveillance; leukemogenesis; microsatellite instability; secondary leukemia; therapy-related AML/MDS; tumor-specific antigen