title: Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.
abstract: OBJECTIVE
  Serum pepsinogen (sPG) has been used to help in diagnosing atrophic corpus gastritis and in screening for gastric cancer non-invasively. There are as yet no reports on sPG reference intervals (RIs) with latex enhanced turbidimetric immunoassay (LIA). In this study, we established the RIs for sPG in a healthy Chinese population using LIA.
  
  
  METHODS
  Serum PGI and PGII levels in a healthy population (aged 17-80 years) were measured simultaneously using LIA. RIs were determined following Clinical Laboratory and Standards Institute C28-A3 guidelines using a non-parametric method.
  
  
  RESULTS
  95% RIs in men (ng/mL) were: ≤40 years old, 25.53-100.76 for PGI and ≤24.42 for PGII; 41-50 years old, 26.62-124.74 for PGI and ≤26.81 for PGII; and 51-80 years old, 30.40-153.25 for PGI and ≤32.62 for PGII. Corresponding RIs for women (ng/mL) were: ≤40 years old, 21.20-87.44 for PGI and ≤25.53 for PGII; and 41-80 years, 26.40-127.46 for PGI and ≤30.18 for PGII. 95% RI for PGI/PGII in both men and women at any age was ≥2.51.
  
  
  CONCLUSIONS
  We established the RIs for sPG using LIA in a healthy Chinese population, which can provide a reference for clinical and laboratory studies.
authors.affiliation: Department of Clinical Laboratory, Second Xiangya Hospital of Central South University, , Changsha, Hunan, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Huang
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Tang
authors.forename: Sa
authors.initials: S
authors.lastname: Mu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Yang
authors.forename: Zhong-Yuan
authors.initials: ZY
authors.lastname: Xiang
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Jia-Jin
authors.initials: JJ
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015992:Body Mass Index; D002681:China; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007840:Latex / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D020116:Pepsinogen A / Q000097:blood*; D012016:Reference Values; D012737:Sex Factors; D055815:Young Adult
chemical_list: D007840:Latex; D020116:Pepsinogen A
keywords: GASTRIC CANCER; GASTRITIS; LABORATORY TESTS; diagnostic screening