title: Brown adipose tissue as an anti-obesity tissue in humans.
abstract: During the 11th Stock Conference held in Montreal, Quebec, Canada, world-leading experts came together to present and discuss recent developments made in the field of brown adipose tissue biology. Owing to the vast capacity of brown adipose tissue for burning food energy in the process of thermogenesis, and due to demonstrations of its presence in adult humans, there is tremendous interest in targeting brown adipose tissue as an anti-obesity tissue in humans. However, the future of such therapeutic approaches relies on our understanding of the origin, development, recruitment, activation and regulation of brown adipose tissue in humans. As reviewed here, the 11th Stock Conference was organized around these themes to discuss the recent progress made in each aspect, to identify gaps in our current understanding and to further provide a common groundwork that could support collaborative efforts aimed at a future therapy for obesity, based on brown adipose tissue thermogenesis.
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Chechi
authors.forename: J
authors.initials: J
authors.lastname: Nedergaard
authors.forename: D
authors.initials: D
authors.lastname: Richard
mesh_terms: D052437:Adipocytes, Brown / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000502:physiology*; D019440:Anti-Obesity Agents / Q000378:metabolism* / Q000627:therapeutic use; D001833:Body Temperature Regulation; D001835:Body Weight; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D022722:Thermogenesis / Q000502:physiology*; D000071256:Uncoupling Protein 1
chemical_list: D019440:Anti-Obesity Agents; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1
keywords: Brown adipose tissue; energy expenditure; sympathetic nervous system; uncoupling protein-1