title: A wavelet relational fuzzy C-means algorithm for 2D gel image segmentation.
abstract: One of the most famous algorithms that appeared in the area of image segmentation is the Fuzzy C-Means (FCM) algorithm. This algorithm has been used in many applications such as data analysis, pattern recognition, and image segmentation. It has the advantages of producing high quality segmentation compared to the other available algorithms. Many modifications have been made to the algorithm to improve its segmentation quality. The proposed segmentation algorithm in this paper is based on the Fuzzy C-Means algorithm adding the relational fuzzy notion and the wavelet transform to it so as to enhance its performance especially in the area of 2D gel images. Both proposed modifications aim to minimize the oversegmentation error incurred by previous algorithms. The experimental results of comparing both the Fuzzy C-Means (FCM) and the Wavelet Fuzzy C-Means (WFCM) to the proposed algorithm on real 2D gel images acquired from human leukemias, HL-60 cell lines, and fetal alcohol syndrome (FAS) demonstrate the improvement achieved by the proposed algorithm in overcoming the segmentation error. In addition, we investigate the effect of denoising on the three algorithms. This investigation proves that denoising the 2D gel image before segmentation can improve (in most of the cases) the quality of the segmentation.
authors.affiliation: Informatics Research Institute, City for Scientific Research and Technological Applications, Borg El Arab, Alexandria, Egypt.
authors.forename: Shaheera
authors.initials: S
authors.lastname: Rashwan
authors.forename: Mohamed Talaat
authors.initials: MT
authors.lastname: Faheem
authors.forename: Amany
authors.initials: A
authors.lastname: Sarhan
authors.forename: Bayumy A B
authors.initials: BA
authors.lastname: Youssef
mesh_terms: D000465:Algorithms; D001798:Blood Proteins / Q000302:isolation & purification; D016000:Cluster Analysis; D015180:Electrophoresis, Gel, Two-Dimensional / Q000706:statistics & numerical data*; D063647:Fetal Alcohol Spectrum Disorders / Q000097:blood; D017143:Fuzzy Logic; D018922:HL-60 Cells; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D007938:Leukemia / Q000097:blood; D009363:Neoplasm Proteins / Q000097:blood / Q000302:isolation & purification; D058067:Wavelet Analysis
chemical_list: D001798:Blood Proteins; D009363:Neoplasm Proteins