title: Thoracic aorta vasoreactivity in rats under exhaustive exercise: effects of Lycium barbarum polysaccharides supplementation.
abstract: BACKGROUND
  Reduced arterial compliance is associated with an increased rate of morbidity and mortality in cardiovascular disease. Exercise is beneficial for compromised arterial compliance. However, the beneficial effects of exercise are lost with exhaustion. Lycium barbarum L. has been used in China for centuries to maintain good health. In this regard, the primary purpose of this study was to characterize the effects of the polysaccharides from Lycium barbarum (LBPs) on arterial compliance during exhaustive exercise.
  
  
  METHODS
  A four-week swimming exercise program was designed for rats, and the blood levels of malondialdehyde (MDA), super oxide dismutase (SOD), nitric oxide(NO) and heat shock protein 70(HSP70) were detected. The tension of aorta rings was measured to evaluate the response of rats on noradrenaline (NA)-induced contractions.
  
  
  RESULTS
  The rats administered LBPs showed longer swimming time until exhaustion than the control group of rats. Exercise-induced MDA elevation was repressed by LBPs supplementation. The LBPs-supplemented rats displayed a significant increase of SOD, NO, HSP70 than the non-supplemented rats. Additionally, LBPs significantly up-regulated the expression of eNOS and improved the endothelium-dependent vasodilatation of the aorta ring.
  
  
  CONCLUSIONS
  Our study proved that LBPs administration significantly inhibited the oxidative stress, and improved the arterial compliance.
authors.affiliation: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Lingqin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Zhang