title: [Pathogenesis of skin injury in immunodeficient rats].
abstract: We investigated the skin condition in rats with immunodeficit induced by cyclophosphane. Cyclophosphane induced in the blood the development of two phases pathological process. The first leukopenic phase is mediated by the action ofcytostatics, and the second hyperleucocytic phase is induced by liver injury and splenomegalia. Dysbiosis and inflammation are developed in the skin, especially during the second phase.
authors.forename: V V
authors.initials: VV
authors.lastname: Shukhtin
authors.forename: A I
authors.initials: AI
authors.lastname: Hozhenko
authors.forename: A P
authors.initials: AP
authors.lastname: Levyts'kyĭ
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003520:Cyclophosphamide; D006820:Hyaluronic Acid / Q000378:metabolism*; D007166:Immunosuppressive Agents; D007249:Inflammation; D008099:Liver / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D010196:Pancreatic Elastase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013163:Splenomegaly / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D008315:Malondialdehyde; D003520:Cyclophosphamide; D006820:Hyaluronic Acid; D002374:Catalase; D010196:Pancreatic Elastase