title: General acteoside of Rehmanniae leaves in the treatment of primary chronic glomerulonephritis: a randomized controlled trial.
abstract: The objective of the study was to investigate the effectiveness and efficacy of the randomized, parallel, and controlled trial of Traditional Chinese Medicine, general acteoside of Rehmanniae leaves, compared with piperazine ferulate in the treatment of primary chronic glomerulonephritis. Rehmanniae leaves and piperazine ferulate can reduce proteinuria and erythrocyturia effectively in the treatment of primary chronic glomerulonephritis. A total of 400 patients diagnosed with primary chronic glomerulonephritis were recruited from outpatient clinics and were randomly assigned to the treatment group (general acteoside of Rehmanniae leaves, two 200mg tablets, bid) or the control group (piperazine ferulate, four 50-mg tablets, bid ). The primary outcome was 24-h urinary protein. Secondary outcome measures included estimated glomerular filtration rate (eGFR), erythrocyturia, and electrolytes. After 8 weeks of treatment, the treatment group and the control group showed a mean reduction in 24-h proteinuria of 34.81% and 37.66%. The 95% CI of difference of the mean reduction in 24-h proteinuria between the two groups was [-11.50%, 5.80%]. No significant differences were found between the two groups in the erythrocyturia reduction. Neither group showed obvious changes between baseline and 8 weeks in eGFR or electrolytes. Adverse events occurred at a similarly low rate in the treatment group (1.5%) and control group (2.5%, P = 0.7238). Both general acteoside of Rehmanniae leaves and piperazine ferulate can reduce proteinuria and erythrocyturia effectively in the treatment of primary chronic glomerulonephritis.
authors.affiliation: Department of Nephrology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China.
authors.forename: HongYu
authors.initials: H
authors.lastname: Qiu
authors.forename: WenXing
authors.initials: W
authors.lastname: Fan
authors.forename: Ping
authors.initials: P
authors.lastname: Fu
authors.forename: Chuan
authors.initials: C
authors.lastname: Zuo
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Zhong
authors.forename: YaPing
authors.initials: Y
authors.lastname: Liang
authors.forename: Mei
authors.initials: M
authors.lastname: Shi
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004573:Electrolytes / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D000077489:Piperazine; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D032267:Rehmannia / Q000737:chemistry*; D059808:Polyphenols
chemical_list: D004573:Electrolytes; D005960:Glucosides; D010636:Phenols; D000077489:Piperazine; D010879:Piperazines; D010936:Plant Extracts; C058956:acteoside; D059808:Polyphenols
keywords: Chronic glomerulonephritis; General acteoside of Rehmanniae leaves; Piperazine ferulate; Randomized controlled trials