title: Targeted silencing of inhibitors of apoptosis proteins with siRNAs: a potential anti-cancer strategy for hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor prognosis. Despite significant improvements in diagnosis and treatment in recent years, the long-term therapeutic efficacy is poor, partially due to tumor metastasis, recurrence, and resistance to chemo- or radio-therapy. Recently, it was found that a major feature of tumors is a combination of unrestrained cell proliferation and impaired apoptosis. There are now 8 recognized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, Survivin, Bruce, Livin and ILP-2. These proteins all contribute to inhibition of apoptosis, and provide new potential avenues of cancer treatment. As a powerful tool to suppress gene expression in mammalian cells, RNAi species for inhibiting IAP genes can be directed against cancers. This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.
authors.affiliation: Department of General Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, China E-mail : changhong@sdu.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.forename: Yun-Peng
authors.initials: YP
authors.lastname: Zhai
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000037:antagonists & inhibitors / Q000235:genetics; D017209:Apoptosis; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000628:therapy*; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D015316:Genetic Therapy; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics / Q000628:therapy*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000037:antagonists & inhibitors / Q000235:genetics; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D000077022:Survivin; D044767:Ubiquitin-Protein Ligases; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000037:antagonists & inhibitors / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C107489:BIRC5 protein, human; C401541:BIRC6 protein, human; C419866:BIRC7 protein, human; C430870:BIRC8 protein, human; D051034:Inhibitor of Apoptosis Proteins; C496800:NAIP protein, human; D009363:Neoplasm Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein; D034741:RNA, Small Interfering; D000077022:Survivin; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; C494833:BIRC2 protein, human; C494832:BIRC3 protein, human; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D044767:Ubiquitin-Protein Ligases