title: [Metabolic differences in healthy first-degree female relatives of type 2 diabetic patients].
abstract: BACKGROUND
  Today the prevalence of type 2 diabetes reached an epidemic level. It is known that type 2 diabetes could only be prevented before the manifestation, during the "prediabetic" state, urging the development of diagnostic tests to recognize the group at risk in time.
  
  
  OBJECTIVE
  The authors explored metabolic differences between healthy, normal glucose tolerant, normal insulin resistant females having first degree relatives with and without type 2 diabetes.
  
  
  METHODS
  Healthy, normal insulin sensitive females without (n = 26) and with (n = 18) type 2 diabetic relatives were investigated.
  
  
  RESULTS
  Healthy females with first degree diabetic relatives had lower low density lipoproteins and higher high density lipoproteins as well as higher glucose and insulin levels at the 120 min of oral glucose test as compared to those without first degree diabetic relatives.
  
  
  CONCLUSIONS
  These results suggest that the appearance of insulin resistance is preceded by hepatic insulin resistance and impaired lipid metabolism in the symptom-free prediabetic period of genetically susceptible females.
authors.affiliation: Budapesti Műszaki és Gazdaságtudományi Egyetem Vegyészmérnöki és Biomérnöki Kar Budapest.
authors.forename: Györgyi
authors.initials: G
authors.lastname: Kovács
authors.forename: Barbara
authors.initials: B
authors.lastname: Buday
authors.forename: Attila
authors.initials: A
authors.lastname: Fék
authors.forename: Botond
authors.initials: B
authors.lastname: Literáti-Nagy
authors.forename: József
authors.initials: J
authors.lastname: Pauer
authors.forename: Péter
authors.initials: P
authors.lastname: Pach
authors.forename: Márta
authors.initials: M
authors.lastname: Vitai
authors.forename: Eva
authors.initials: E
authors.lastname: Péterfai
authors.forename: László
authors.initials: L
authors.lastname: Korányi
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005190:Family; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D015675:Osteocalcin / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis*; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D053244:Osteoprotegerin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D015675:Osteocalcin; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein
keywords: diabetes mellitus type 2; early metabolic alterations; genetically diabetic; genetically non-diabetic; genetikailag diabeteses; genetikailag nem diabeteses; korai anyagcsere-eltérések; praediabetes; prediabetic state