title: Recent advances in humanized mice: accelerating the development of an HIV vaccine.
abstract: Recent advances in the development of humanized mice hold great promise to advance our understanding of protective immunity to human immunodeficiency virus (HIV) infection and to aid in the design of an effective HIV vaccine. This supplement of the Journal of Infectious Diseases summarizes work in the humanized mouse model presented at an HIV Humanized Mouse workshop in Boston, Massachusetts, in November 2012, including recent advances in the development of humanized mice, the trafficking of human immune cells following mucosal HIV transmission, the role of immune activation and Toll-like receptor agonists in the control of HIV, the induction and efficacy of HIV-specific cellular and humoral immune responses, and the preclinical modeling of novel anti-HIV therapeutics. Many gaps remain in our understanding of how to design an effective HIV vaccine and novel therapeutics to eliminate the viral reservoir. Promising early results from studies in humanized mice suggest great potential and enthusiasm for this model to accelerate these critical areas of HIV research.
authors.affiliation: Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Tager
authors.forename: Michael
authors.initials: M
authors.lastname: Pensiero
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D051379:Mice; D016513:Mice, SCID
chemical_list: D016915:AIDS Vaccines
keywords: CD8+ T cells; CTL; HIV; antibodies; humanized mice; vaccine