title: Stressing the development of small molecules targeting HSP90.
abstract: Inhibitors of the molecular chaperone HSP90 have been in clinical development as anticancer agents since 1999. Recent clinical studies, including the work of Saif and colleagues in this issue of Clinical Cancer Research, demonstrate that significant progress has been made in overcoming the obstacles preventing regulatory approval.
authors.affiliation: Authors' Affiliations: Urologic Oncology Branch and Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Len
authors.initials: L
authors.lastname: Neckers
authors.forename: Jane B
authors.initials: JB
authors.lastname: Trepel
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: C521963:6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine; D000970:Antineoplastic Agents; D011725:Pyridines; D000225:Adenine