title: Effect of local application of tea tree (Melaleuca alternifolia) oil gel on long pentraxin level used as an adjunctive treatment of chronic periodontitis: A randomized controlled clinical study.
abstract: BACKGROUND
  Conventional non-surgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Tea tree oil (TTO) can be used as adjunct to conventional periodontal therapy in patient with chronic periodontitis. The aim of this study was to evaluate the effectiveness of adjunctive treatment of TTO on the clinical parameters and the level of pentraxin-3 (PTX3) in chronic periodontitis.
  
  
  METHODS
  A total of 40 patients with moderate to severe chronic periodontitis were divided into two groups, Group I received scaling and root planing (SRP) only, Group II received SRP and TTO gel. Clinical parameters were recorded and gingival crevicular fluid (GCF) samples were collected from each subject for measuring PTX3 levels at baseline, 1, 3 and 6 months after treatment.
  
  
  RESULTS
  In all evaluation periods, there was statistically significant reduction in each of the studied clinical parameters and PTX3 level in Group II as compared with Group I.
  
  
  CONCLUSIONS
  The local delivery of TTO gel in case of chronic periodontitis may have some beneficial effects to augment the results of the conventional periodontal therapy. Moreover, it places a focus on the value of monitoring GCF levels of PTX3 as a marker of periodontal tissue healing.
authors.affiliation: Department of Oral Medicine and Periodontology, Faculty of Dentistry, October 6 University, Egypt.
authors.forename: Enas Ahmed
authors.initials: EA
authors.lastname: Elgendy
authors.forename: Shereen Abdel-Moula
authors.initials: SA
authors.lastname: Ali
authors.forename: Doaa Hussien
authors.initials: DH
authors.lastname: Zineldeen
keywords: Chronic periodontitis; pentraxin-3; tea tree oil