title: Application of PRF in surgical management of periapical lesions.
abstract: OBJECTIVE
  Platelet rich fibrin is widely used in stimulation and acceleration of soft tissue and bone healing because of local and continuous delivery of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes. This article will serve to introduce a second generation platelet concentrate, platelet-rich fibrin (PRF).
  
  
  METHODS
  Fifteen cases are presented in which conventional endodontic therapy failed to resolve the problem and periapical root-end surgery was required.
  
  
  RESULTS
  At the end of six months, all patients showed complete bone regeneration.
  
  
  CONCLUSIONS
  Production of a dense, cross-linked, physically robust PRF made of intact platelets and fibrin by high-speed centrifugation in the absence of exogenous thrombin, yields an ideal scaffold for use in tissue repair.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Darshan Dental College and Hospital, Udaipur, Rajasthan, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Singh
authors.forename: Arunendra
authors.initials: A
authors.lastname: Singh
authors.forename: Sourav
authors.initials: S
authors.lastname: Singh
authors.forename: Rashmi
authors.initials: R
authors.lastname: Singh
keywords: Periapical surgery; platelet growth factor; platelet rich fibrin; wound healing