title: CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population.
abstract: BACKGROUND
  CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population.
  
  
  METHODS
  In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay.
  
  
  RESULTS
  For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females.
  
  
  CONCLUSIONS
  The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University , Urumqi , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Fu
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Cha
authors.initials: C
authors.lastname: Erdenbat
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012737:Sex Factors
chemical_list: D003577:Cytochrome P-450 Enzyme System; C465478:CYP4A11 protein, human; D042926:Cytochrome P-450 CYP4A
keywords: CYP4A11; T8590C; cytochrome P450; essential hypertension; polymorphism