title: Triple simultaneous primary invasive gynecological malignancies: a case report.
abstract: Double gynecologic cancer (primary cancers in two organs) is relatively rare. However, triple gynecologic cancer (primary cancers in three organs) is extremely rare. We experienced a case of triple cancer, with primary cervical, endometrial and ovarian cancers, each showing different histopathological features. A 50-year-old woman with a preoperative diagnosis of cervical cancer stage Ib1 with a pathological diagnosis of mucinous adenocarcinoma underwent radical hysterectomy. The pathological diagnoses of the extracted masses were endometrioid adenocarcinoma in the uterine corpus and serous adenocarcinoma in the left ovary. Consequently, triple cancer was diagnosed. After the operation, six cycles of a paclitaxel/carboplatin regimen were administered, and no relapse of the cancers has been observed to date. To our knowledge, this is only the second case report in the international literature of concurrent gynecologic triple cancers of epithelial origin; that is, invasive cervical, endometrial and ovarian cancers, each with different histopathological features.
authors.affiliation: Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Takatori
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Shoji
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Uesugi
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy
keywords: cervix; endometrium; ovary; synchronous primaries; triple cancer