title: Long-term results of endoscopic resection for type I gastric neuroendocrine tumors.
abstract: BACKGROUND
  A number of different therapies, including endoscopic resection, have been suggested for the treatment of Type 1 gastric neuroendocrine tumors (NETs). The current study aimed to determine the long-term efficacy of endoscopic resection for Type 1 gastric NETs.
  
  
  METHODS
  Twenty-two patients (from 1999 to 2012) with Type 1 gastric NETs were included in the study. All patients were treated with endoscopic resection and received regular followed-up appointments at a tertiary referral center.
  
  
  RESULTS
  All patients were initially diagnosed with hypergastrinemia, atrophic gastritis and intestinal metaplasia. Polyps' diameters were >1 cm in 4 patients, and between 0.5 and 1 cm in 18 patients. All detectable lesions were successfully resected. One patient required surgery due to gastric perforation during endoscopic mucosal resection. Recurrence was detected in four patients (18%) and endoscopic resection was performed again. Local or distant metastasis was not observed in any patient during follow-up. Median follow-up time was 7 years, with a maximum of 14 years. Seventeen patients (78%) completed a 5-year follow-up period, and overall disease-free survival rate was 100%.
  
  
  CONCLUSIONS
  Long-term follow-ups with 22 patients suggest that endoscopic resection of Type 1 gastric NETs is a safe and effective treatment option with a relatively low recurrence rate.
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uygun
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kadayifci
authors.forename: Zulfikar
authors.initials: Z
authors.lastname: Polat
authors.forename: Kemalettin
authors.initials: K
authors.lastname: Yilmaz
authors.forename: Armagan
authors.initials: A
authors.lastname: Gunal
authors.forename: Hakan
authors.initials: H
authors.lastname: Demir
authors.forename: Sait
authors.initials: S
authors.lastname: Bagci
mesh_terms: D000328:Adult; D000368:Aged; D053379:Chromogranin A / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000601:surgery; D005755:Gastrins / Q000097:blood; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors / Q000145:classification / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011127:Polyps / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D012086:Reoperation; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*
chemical_list: D053379:Chromogranin A; D005755:Gastrins
keywords: endoscopic mucosectomy; gastric carcinoid; neuroendocrine tumors