title: 18F-FDG PET/CT for staging and detection of extramedullary organ involvement in chronic myelomonocytic leukemia.
abstract: Chronic myelomonocytic leukemia (CMML) is a rare hematologic malignancy characterized by the accumulation of monocytes in the blood and bone marrow, dysplastic hematopoiesis, and potential leukemic involvement of organs. We report a case of leukemic involvement of cervical lymph nodes detected by 18F-FDG PET/CT. A 53-year-old woman with CMML and newly diagnosed cervical lymphadenopathy underwent whole-body PET/CT for evaluation of extramedullary disease. PET demonstrated marked tracer uptake in cervical lymph nodes. Histopathological evaluation revealed leukemic involvement. 18F-FDG PET/CT is a valuable tool enabling sensitive staging of CMML, particularly in case of extramedullary organ involvement.
authors.affiliation: From the *Department of Diagnostic and Interventional Radiology, and †Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Till Sebastian
authors.initials: TS
authors.lastname: Clauditz
authors.forename: Peter
authors.initials: P
authors.lastname: Bannas
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18