title: Clinical effectiveness of thyroidectomy on the management of locally advanced laryngeal cancer.
abstract: OBJECTIVE
  The incidence of thyroid gland invasion in patients with advanced laryngeal cancer was reported to be 0-50%. However there is a controversy in necessity and extent of routine thyroidectomy in these patients due to the difficulty in diagnosis of tumor invasion to thyroid gland and the risk of possible postoperative hypothyroidism and hypocalcemia.
  
  
  METHODS
  The medical files of 47 patients who underwent thyroidectomy as part of surgical treatment for advanced laryngeal cancer were reviewed.
  
  
  RESULTS
  Fourty-four (93.6%) patients underwent hemithyroidectomy, 3 (6.3%) patients underwent total thyroidectomy. Thyroid gland invasion was found in 2 (4.2%) patients. Hypothyroidism occurred in 15 (31.9%) patients, and their hormone levels were regulated with medical treatment during follow-up. Hypocalcemia was not found in any patients.
  
  
  CONCLUSIONS
  We recommend that at least a hemithyroidectomy should be performed in patients with advanced laryngeal cancer, if they have any predictive factor (subglottic extension more than 1cm, invasion of paraglottic space, thyroid cartilage, cricoid cartilage and prelaryngeal tissue detected by radiological examination) for thyroid gland invasion.
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Otorhinolaryngology, Turkey. Electronic address: mkezban@yahoo.com.tr.
authors.forename: Melek Kezban
authors.initials: MK
authors.lastname: Gürbüz
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Pathology, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Açikalin
authors.affiliation: Eskisehir Government Hospital, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Tasar
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Otorhinolaryngology, Turkey.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Cakli
authors.affiliation: Batman Regional Hospital, Turkey.
authors.forename: Göknur
authors.initials: G
authors.lastname: Yorulmaz
authors.affiliation: Medical Park Hospital, Uşak, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Erdinç
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Otorhinolaryngology, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Özüdoğru
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Otorhinolaryngology, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Keçik
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Biostatistics, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Colak
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Radiology, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Saylisoy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000209:etiology; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D013961:Thyroid Gland / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*
keywords: Advanced; Invasion; Laryngeal cancer; Thyroid gland; Thyroidectomy