title: Recent progress in the development of histone deacetylase inhibitors as anti-cancer agents.
abstract: Histone deacetylases (HDACs) regulate the expression and activity of many proteins in both cancer initiation and cancer progression. HDACs are now recognized as promising targets for anticancer agent development. HDAC inhibitors (HDACIs) are emerging as promising anticancer drugs which possess tumor-selective cytotoxicity. HDACIs could promote growth arrest, differentiation, and apoptosis of cancer cells, with minimal effects on normal tissue. Research of HDACIs is now becoming an interesting field. HDACIs comprise structurally diverse anticancer agents and have been widely used in the clinic. This review describes recent progress in the development of HDACIs, especially focusing on the design strategies, novel chemical structures, biological properties and structure-activity relationships (SARs) of HDACIs. We hope it will be helpful for medicinal chemists who are interested in the discovery of anticancer agents.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jine
authors.initials: J
authors.lastname: Lei
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shan
authors.forename: Hao
authors.initials: H
authors.lastname: Yang
authors.forename: Maxiaowei
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, No. 277, Yanta West Road, Xi'an, Shaanxi Province, 710061, P.R. China. mxf2m3m@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000813:Anilides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; D001688:Biological Products; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D007659:Ketones; D047028:Macrocyclic Compounds; D006655:Histone Deacetylases