title: CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert.
abstract: Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor.
authors.affiliation: Authors' Affiliations: Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Zhu
authors.forename: Lieping
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism*; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000378:metabolism*
chemical_list: D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9