title: Transperineal reanastomosis for the treatment for highly recurrent anastomotic strictures as a last option before urinary diversion.
abstract: OBJECTIVE
  To evaluate safety and efficacy of open transperineal reanastomosis (TPRA) for highly recurrent anastomotic strictures (AS) after radical prostatectomy. While the majority of AS can be managed successfully by endoscopic treatment, in highly recurrent AS, open reanastomosis represents a viable therapeutic option.
  
  
  METHODS
  Retrospective analysis by standardized questionnaire, inquiring for recurrence, incontinence, sexual function, satisfaction and changes in quality of life (QoL) in 15 patients undergoing TPRA 08/2007-03/2010.
  
  
  RESULTS
  Mean patient age was 65 years (51-75) and mean follow-up 20.5 months (5.8-37.0). Success rate was 93.3 % (14/15). The single recurrence was successfully treated by cold knife incision. Incontinence was found in 93.3 % (14/15) preoperatively and aggravated in 60 % (9/15) after surgery; no de novo incontinence occurred. Implantation of an artificial urinary sphincter (AUS) has been performed successfully in 10 patients, 2 refused implantation and 2 are scheduled for surgery. Erectile dysfunction was present in 86.7 % (13/15); 13.3 % (2/15) reported a severely declined rigidity. Compared to preoperative status, 33.3 % (5/15) complained about impaired erectile function after TPRA. A good or very good subjective overall health status and an improvement in QoL were noted in 86.7 % (13/15). Patient satisfaction with the outcome of TPRA was high or very high in 13; two were undecided.
  
  
  CONCLUSIONS
  After repeated endoscopic treatment, TPRA is a valuable therapeutic option in selected patients with an overall success rate of 93.3 % (14/15) for anastomotic patency, which can even be raised to 100 % by further transurethral surgery. Incontinence can be easily treated by implantation of an AUS.
authors.affiliation: Department of Urology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
authors.forename: Christoph Philip
authors.initials: CP
authors.lastname: Reiss
authors.forename: Daniel
authors.initials: D
authors.lastname: Pfalzgraf
authors.forename: Luis Alex
authors.initials: LA
authors.lastname: Kluth
authors.forename: Armin
authors.initials: A
authors.lastname: Soave
authors.forename: Margit
authors.initials: M
authors.lastname: Fisch
authors.forename: Roland
authors.initials: R
authors.lastname: Dahlem
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D003251:Constriction, Pathologic / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum; D011183:Postoperative Complications / Q000601:surgery*; D011468:Prostatectomy; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D014521:Urethra / Q000601:surgery*; D014547:Urinary Diversion