title: Epithelial-mesenchymal transition and its regulators are major targets of triple-negative breast cancer.
abstract: Triple negative breast cancers (TNBCs) represent a distinct subtype of breast cancers that are associated with early recurrence and an aggressive metastatic progression of the disease and consequently poor outcome. Recently, it was reported that c-Met growth factor receptor is overexpressed in around 52% of TNBCs. On the other hand, it is known that c-Met signaling pathways initiate the epithelial-mesenchymal transition (EMT) phenomenon, which is described as a crucial event during cancer metastasis. Herein, we discuss the association between c-Met and EMT in the TNBC group.
authors.affiliation: Department of Mechanical Engineering; Concordia University; Oncology Department; McGill University; and ABS Research & Development; Montreal, QC Canada; Syrian Research Cancer Centre of the Syrian Society against Cancer; Aleppo, Syria.
authors.forename: Ala-Eddin
authors.initials: AE
authors.lastname: Al Moustafa
mesh_terms: D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis; D015398:Signal Transduction / Q000235:genetics; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D020738:Leptin; D019859:Proto-Oncogene Proteins c-met
keywords: EMT; IGF-1; Leptin; breast cancer; c-Met; metastasis & cancer mortality; triple negative