title: [Effects of retinol acid and triiodothyronine on alleviating the impairment of cognitive function by sleep deprivation].
abstract: OBJECTIVE
  To explore the effects of retinol acid (RA) and triiodothyronine (T3) on alleviating the impairment of cognitive function by sleep deprivation (SD).
  
  
  METHODS
  Male Wistar rats were divided into 4 groups: control group (C group), sleep deprivation group (SD group), sleep deprivation + RA group (SD + RA group) and sleep deprivation + T3 group (SD + T3 group). Open field test (OFT) was used to observe the nervous behavior of the rats after SD and electrophysiological brain stereotactic method was used to test long-term potentiation (LTP) in dentate gyrus (DG) of the rats. Ng protein expression was determined by Western blot.
  
  
  RESULTS
  Compared with the SD group, the number of crossing in OFT, the changes of amplitude of population spike (PS) and the expression of Ng protein in hippocampus were higher significantly in the SD + RA and SD + T3 groups. All of these had not significant difference comparing with the C group.
  
  
  CONCLUSIONS
  RA and T3 may alleviate the restrain state of neural system after SD by augmenting the expression of Ng protein in hippocampus.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Chen
authors.forename: Chuan-Xiang
authors.initials: CX
authors.lastname: Xu
authors.forename: Gai-Hong
authors.initials: GH
authors.lastname: An
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: She
mesh_terms: D000818:Animals; D003071:Cognition / Q000187:drug effects*; D018891:Dentate Gyrus / Q000378:metabolism; D017774:Long-Term Potentiation; D008297:Male; D051579:Neurogranin / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000378:metabolism* / Q000523:psychology; D014284:Triiodothyronine / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D014284:Triiodothyronine; D014801:Vitamin A; D051579:Neurogranin