title: Is human kallikrein-11 in gastric cancer treated with surgery and adjuvant chemoradiotherapy associated with survival?
abstract: Human kallikreins (hKs) have been reported to be involved in human cancers, and several hKs are promising biomarkers of various cancers, such as prostate, ovarian, breast, and testicular cancer. In the present study, we aimed to evaluate the prognostic value of immunohistochemical expression of hK11 in patients with gastric cancer. The study included 55 (36 men and 19 women; 58 ± 10 years of mean age) patients with gastric cancer treated with surgery and adjuvant chemoradiotherapy. Tissue sections were evaluated immunohistochemically with a monoclonal anti-hK11 antibody. Of the 55 patients, 35 (63.6%) were hK11-positive and 20 (36.4%) were hK11-negative. Disease-free and overall survival rates were significantly higher in patients with hK11 positive than in those with hK-11 negative expression (24 months vs. 11 months, p: 0.043; 29 months vs. 13 months, p: 0.038, respectively). In conclusion, hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. On the other hand, it is needed to elucidate the mechanisms underlying the regulation of hK11 expression in gastric cancer.
authors.affiliation: Department of Radiation Oncology, Kayseri Education and Research Hospital, Kayseri, Turkey. Electronic address: dilekunaldr@gmail.com.
authors.forename: Dilek
authors.initials: D
authors.lastname: Unal
authors.forename: Arzu
authors.initials: A
authors.lastname: Tasdemir
authors.forename: Arzu
authors.initials: A
authors.lastname: Oguz
authors.forename: Celalettin
authors.initials: C
authors.lastname: Eroglu
authors.forename: Yasemin Benderli
authors.initials: YB
authors.lastname: Cihan
authors.forename: Esra Ermis
authors.initials: EE
authors.lastname: Turak
authors.forename: Hatice
authors.initials: H
authors.lastname: Karaman
authors.forename: Serdar
authors.initials: S
authors.lastname: Soyuer
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D059186:Chemoradiotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012697:Serine Endopeptidases / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C114880:trypsin-like serine protease; D012697:Serine Endopeptidases
keywords: Gastric cancer; Human kallikrein-11; Prognosis