title: Vitamin D receptor gene and risk of fracture in postmenopausal women: a meta-analysis.
abstract: OBJECTIVE
  Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and fracture risk, but evidence remains conflicting. The aim of this study was to evaluate the genetic effect of the BsmI, TaqI, ApaI and FokI polymorphisms in the VDR gene on fracture risk in postmenopausal women.
  
  
  METHODS
  Relevant studies were identified from the following electronic databases: PubMed, Embase, and Web of Science before September 2013. Statistical analysis was performed by using the software STATA 12.0. A total 1975 fracture cases and 4565 controls in 14 studies with a total of 16 eligible comparisons were identified for data analysis.
  
  
  RESULTS
  No evidence of relationship between the VDR BsmI, TaqI, ApaI or FokI polymorphisms and fracture risk was observed with any genetic model in postmenopausal women (BsmI: b vs. B: odds ratio (OR) 1.07, 95% confidence interval (CI) 0.90-1.29; TaqI: T vs. t: OR 0.89, 95% CI 0.68-1.15; ApaI: A vs. a: OR 0.91, 95% CI 0.76-1.08; FokI: F vs. f: OR 1.20, 95% CI 0.76-1.90).
  
  
  CONCLUSIONS
  This meta-analysis suggests that ApaI, BsmI, TaqI and FokI polymorphisms may be not associated with the risk of fracture in postmenopausal women. Further studies in a larger sample population are required to confirm this finding.
authors.affiliation: Department of Orthopedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine , Shanghai.
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Lu
mesh_terms: D016001:Confidence Intervals; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases; C027046:TCGA-specific type II deoxyribonucleases
keywords: FRACTURE; GENE POLYMORPHISM; META-ANALYSIS; VITAMIN D RECEPTOR