title: Synthesis and anionophoric activities of dimeric polyamine-sterol conjugates: the impact of rigid vs. flexible linkers.
abstract: Two dimeric spermine-choloyl conjugates were synthesized and found to be capable of promoting the transport of anions across egg-yolk L-α-phosphatidylcholine-based liposomal membranes, via an anion-exchange mechanism and with moderate selectivity with respect to monoanionic ions. A Hill analysis indicated that these two conjugates exhibited similar aggregation behaviors. However, the conjugate bearing a rigid p-bis(aminomethyl)benzene moiety functioned more efficiently than the analogue having a flexible putrescine linker.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. whchen@smu.edu.cn.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Lu
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Deng
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Zhong-Zhen
authors.initials: ZZ
authors.lastname: Zhou
authors.forename: Guan-Song
authors.initials: GS
authors.lastname: Hu
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
mesh_terms: D000838:Anions / Q000138:chemical synthesis / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry*; D019281:Dimerization; D004530:Egg Yolk / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000838:Anions; D003432:Cross-Linking Reagents; D008081:Liposomes; D010713:Phosphatidylcholines; D011073:Polyamines; D013261:Sterols