title: Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies.
authors.affiliation: 1] Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA [2] El Paso Children's Hospital, El Paso, TX, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Ross
authors.affiliation: Molecular Biotechnology Center, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Spadaro
authors.affiliation: Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Rosado
authors.affiliation: Molecular Biotechnology Center, University of Turin, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cavallo
authors.affiliation: Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Kirken
authors.affiliation: Division of Targeted Therapeutics, EP Pharma, Inc., El Paso, TX, USA.
authors.forename: F
authors.initials: F
authors.lastname: Pericle
mesh_terms: D000284:Administration, Oral; D003516:Cycloparaffins / Q000494:pharmacology / Q000627:therapeutic use*; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D053616:Janus Kinase 3 / Q000037:antagonists & inhibitors*; D007659:Ketones / Q000494:pharmacology / Q000627:therapeutic use*; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C000588855:2-(hydroxymethyl)-12-methylenecyclododecanone; D003516:Cycloparaffins; D007659:Ketones; D047428:Protein Kinase Inhibitors; D053616:Janus Kinase 3