title: [Agranulocytosis induced by levamisole in association to cocaine].
abstract: Agranulocytosis in cocaine users is a worldwide recently recognized condition. It is due to the utilization as cutting agent of levamisole, an ancient antiparasitic and immunomodulator drug. We describe the case of a patient with agranulocytosis induced by levamisole in association to cocaine and we review clinical and biochemical characteristics of the clinical picture, as well as the management of these patients. We also analyze the reasons related to a more and more frequent practice, the addition of levamisole to cocaine. This is the first case described in our country, although it is probable that there are many not recognized or not described cases related to this pathology.
authors.affiliation: Servicio de Clínica Médica, Hospital Británico de Buenos Aires. E-mail: debopellegrini@hotmail.com.
authors.forename: Débora
authors.initials: D
authors.lastname: Pellegrini
authors.forename: Pablo
authors.initials: P
authors.lastname: Young
authors.forename: Verónica
authors.initials: V
authors.lastname: Grosso
authors.forename: María
authors.initials: M
authors.lastname: Massa
authors.forename: Julio E
authors.initials: JE
authors.lastname: Bruetman
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000150:complications*; D006801:Humans; D007978:Levamisole / Q000009:adverse effects*; D008297:Male; D016896:Treatment Outcome
chemical_list: D007978:Levamisole; D003042:Cocaine
keywords: agranulocytosis; cocaine; levamisole; neutropenia