title: Reconstruction of perineal defects.
abstract: BACKGROUND
  Perineal defects are commonly encountered in an oncological setting although they may also present as a result of trauma and infection (eg following Fournier's gangrene). Reconstruction of these poses functional as well as aesthetic challenges. Skin coverage and tissue volume may both be required in addition to anogenital preservation or reconstruction. General prerequisites of an adequate reconstruction of perineal defects include provision of skin cover, well vascularised tissue to fill the dead space (reducing fluid collection and infection), vulvovaginal reconstruction and no faecal or urinary contamination.
  
  
  METHODS
  A literature search was performed using PubMed and MEDLINE ® . The search terms included 'perineal defects', 'perineal reconstruction', 'perforator flaps for perineum', 'vulval flaps', 'secondary healing of wound' and 'vacuum assisted closure'. Backward chaining of reference lists from retrieved papers was also used to expand the search.
  
  
  RESULTS
  Modern developments have led to an increased expectation in improved quality of life as the main goal of reconstruction, therefore necessitating surgery with less morbidity and early return to normal activity. Progress in microsurgical procedures has been the main recent advance in perineal reconstruction and, in future, refinements in perforator flap design and tissue engineering techniques will lead to even better reconstructions.
authors.affiliation: Royal Free London NHS Foundation Trust, UK; Royal Free Hospital, Pond Street, London NW3 2QG, UK. leeha_h82@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Mughal
authors.forename: R J
authors.initials: RJ
authors.lastname: Baker
authors.forename: A
authors.initials: A
authors.lastname: Muneer
authors.forename: A
authors.initials: A
authors.lastname: Mosahebi
mesh_terms: D064592:Autografts; D006801:Humans; D054843:Negative-Pressure Wound Therapy / Q000379:methods; D010502:Perineum / Q000601:surgery*; D017568:Rectus Abdominis / Q000637:transplantation; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology