title: Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.
abstract: The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.
authors.affiliation: UMR Inserm 665, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe, France ; Laboratoire ACTES (EA 3596), Département de Physiologie, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe,  France ; Laboratory of Excellence GR-Ex "The red cell: from genesis to death", PRES Sorbonne Paris Cité, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Waltz
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
authors.forename: Yann
authors.initials: Y
authors.lastname: Lamarre
authors.forename: Lydia
authors.initials: L
authors.lastname: Divialle-Doumdo
authors.forename: Marie
authors.initials: M
authors.lastname: Petras
authors.forename: Vanessa
authors.initials: V
authors.lastname: Tarer
authors.forename: Régine
authors.initials: R
authors.lastname: Hierso
authors.forename: Kizzy-Clara
authors.initials: KC
authors.lastname: Baltyde
authors.forename: Benoît
authors.initials: B
authors.lastname: Tressières
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Lalanne-Mistrih
authors.forename: Fréderic
authors.initials: F
authors.lastname: Maillard
authors.forename: Olivier
authors.initials: O
authors.lastname: Hue
authors.forename: Maryse
authors.initials: M
authors.lastname: Etienne-Julan
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D004912:Erythrocytes / Q000473:pathology; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005319:Fetal Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D016138:Walking / Q000502:physiology*
chemical_list: D005319:Fetal Hemoglobin