title: Pharmacokinetics, metabolism, andin vivoefficacy of the antimalarial natural product bromophycolide A.
abstract: A suite of pharmacokinetic and pharmacological studies show that bromophycolide A (1), an inhibitor of drug-sensitive and drug-resistantPlasmodium falciparum, displays a typical small molecule profile with low toxicity and good bioavailability. Despite susceptibility to liver metabolism and a shortin vivohalf-life,1significantly decreased parasitemia in a malaria mouse model. Combining these data with prior SAR analyses, we demonstrate the potential for future development of1and its bioactive ester analogs.
authors.affiliation: School of Biology and School of Chemistry and Biochemistry, Aquatic Chemical Ecology Center and Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Teasdale
authors.forename: Jacques
authors.initials: J
authors.lastname: Prudhomme
authors.forename: Manuel
authors.initials: M
authors.lastname: Torres
authors.forename: Matthew
authors.initials: M
authors.lastname: Braley
authors.forename: Serena
authors.initials: S
authors.lastname: Cervantes
authors.forename: Shanti C
authors.initials: SC
authors.lastname: Bhatia
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Karine
authors.initials: K
authors.lastname: Le Roch
authors.forename: Julia
authors.initials: J
authors.lastname: Kubanek
keywords: Bromophycolide; Malaria