title: Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis.
abstract: Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.
authors.affiliation: Departments of Pediatrics.
authors.forename: Lucas R
authors.initials: LR
authors.lastname: Hoffman
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Pope
authors.forename: Hillary S
authors.initials: HS
authors.lastname: Hayden
authors.forename: Sonya
authors.initials: S
authors.lastname: Heltshe
authors.forename: Roie
authors.initials: R
authors.lastname: Levy
authors.forename: Sharon
authors.initials: S
authors.lastname: McNamara
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jacobs
authors.forename: Laurence
authors.initials: L
authors.lastname: Rohmer
authors.forename: Matthew
authors.initials: M
authors.lastname: Radey
authors.forename: Bonnie W
authors.initials: BW
authors.lastname: Ramsey
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Brittnacher
authors.forename: Elhanan
authors.initials: E
authors.lastname: Borenstein
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D064806:Dysbiosis / Q000150:complications* / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000150:complications* / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Escherichia coli; cystic fibrosis; inflammation; malabsorption; microbiota