title: Retinal nerve fiber layer thickness in a population of 12-year-old children in central China measured by iVue-100 spectral-domain optical coherence tomography: the Anyang Childhood Eye Study.
abstract: OBJECTIVE
  To study the distribution of peripapillary retinal nerve fiber layer (RNFL) thickness in a population of 12-year-old children in central China using iVue-100 spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Twelve-year-old students (n = 2105) from four randomly selected middle schools in Anyang, China, participated in the study. Each child underwent ocular examinations, including optical biometry, cycloplegic autorefraction, and SD-OCT (iVue-100). Glaucoma optic nerve head scan was performed to measure RNFL thickness. Only the children with a signal strength index higher than 45 were included in the analyses. Multivariate analyses were performed to examine the association of RNFL with demographic variables (e.g., sex, age, and body mass index [BMI]) and ocular variables (e.g., axial length and refractive error).
  
  
  RESULTS
  Optical coherence tomography scans of adequate quality were available for 1955 children (92.9%). The mean (SD) RNFL thickness was 103.08 (9.01) μm, with the mean (SD) thickest RNFL in the inferior quadrant (129.34 [14.90] μm), followed by the superior (126.19 [15.24] μm), temporal (82.98 [10.57] μm), and nasal (73.82 [13.89] μm) quadrants. The RNFL was thicker with shorter axial length (β = -1.53, P < 0.0001) and with higher hyperopia (β = 0.90, P < 0.0001). Girls had slightly thicker average RNFL thickness than boys (P < 0.0001). The RNFL thickness had no significant correlation with age or BMI.
  
  
  CONCLUSIONS
  This study establishes normative peripapillary RNFL values of 12-year-old Chinese children as measured by iVue-100 SD-OCT. The RNFL thickness decreased significantly with increasing axial length and higher myopia.
authors.affiliation: Department of Ophthalmology, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.
authors.forename: Bi-Dan
authors.initials: BD
authors.lastname: Zhu
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.forename: Luo-Ru
authors.initials: LR
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yang
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Li
authors.forename: Meng-Tian
authors.initials: MT
authors.lastname: Kang
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Qi
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Zhan
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D015995:Prevalence; D011379:Prognosis; D012016:Reference Values; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Chinese children; iVue-100; retinal nerve fiber layer thickness; spectral-domain optical coherence tomography