title: Relapse of asthma after surgical treatment of Cushing's syndrome.
abstract: Endogenous overproduction of glucocorticoids may mask the clinical course of some inflammatory/ autoimmune disorders. In the present paper, we report a man with a history of asthma, which spontaneously remitted after 20 years of duration. Several years later, he was diagnosed with Cushing's syndrome of pituitary origin and underwent transsphenoidal microsurgery of an ACTH-producing pituitary adenoma. Shortly after tumour removal, he developed a severe asthmatic attack requiring hospitalisation and intensive treatment. We conclude that patients with Cushing's syndrome and coexisting inflammatory/autoimmune disorders should be closely supervised after normalisation of cortisol production for exacerbation of the associated disease and would eventually benefit from glucocorticoid treatment.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl
authors.forename: R
authors.initials: R
authors.lastname: Krysiak
authors.forename: A
authors.initials: A
authors.lastname: Kedzia
authors.forename: B
authors.initials: B
authors.lastname: Okopien
mesh_terms: D000328:Adult; D001249:Asthma / Q000473:pathology*; D003480:Cushing Syndrome / Q000601:surgery*; D006801:Humans; D008297:Male; D012008:Recurrence