title: Isotretinoin: update on controversial issues.
abstract: Acne vulgaris is a commonly seen dermatologic condition that plagues millions and can be very psychosocially disabling. Severe and recalcitrant acne is typically treated with isotretinoin. Isotretinoin is a synthetic vitamin A derivative that has been available since 1982.This therapeutic option has been the most effective at putting severe and recalcitrant acne vulgaris into remission. Despite its effectiveness,it has been associated with inflammatory bowel disease, depression, suicidality, and teratogenicity. We review the current literature on isotretinoin's role in inflammatory bowel disease, depression, and suicidality. In addition, we review whether or not the iPledge program has been successful at reducing pregnancy rates while on isotretinoin.
authors.forename: Noel
authors.initials: N
authors.lastname: Prevost
authors.forename: Joseph C
authors.initials: JC
authors.lastname: English
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D003863:Depression / Q000453:epidemiology*; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000517:prevention & control; D012307:Risk Factors; D059020:Suicidal Ideation; D013723:Teratogens
chemical_list: D003879:Dermatologic Agents; D013723:Teratogens; D015474:Isotretinoin