title: The vesicular ATPase: a missing link between acidification and exocytosis.
abstract: The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked.
authors.affiliation: Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: P Robin
authors.initials: PR
authors.lastname: Hiesinger
mesh_terms: D000818:Animals; D005089:Exocytosis; D009474:Neurons / Q000201:enzymology*; D022142:Secretory Vesicles / Q000201:enzymology*; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000201:enzymology*; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D025262:Vacuolar Proton-Translocating ATPases