title: Practice tips and tools for the successful use of U-500 regular human insulin: the diabetes educator is key.
abstract: This review provides information to equip diabetes educators to instruct and guide patients in using U-500 human regular insulin (U-500R). The article includes an overview of U-500R pharmacology and clinical data, strategies for outpatient and inpatient use, and tools for patient education. U-500R is useful for treating patients with any type of diabetes who require high doses of insulin. U-500R alleviates the volume-related problems associated with high doses of U-100 insulin, making treatment with high doses of insulin more feasible (because of the need for fewer injections for patients) as well as more cost-efficient and potentially more effective. These tools can help diabetes educators feel more comfortable and confident as they advise and educate patients who receive high-dose U-500R as part of their overall diabetes care plan. The diabetes educator plays a vital role in helping patients use U-500R safely and successfully.
authors.affiliation: The National Institutes of Health/National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland (Ms Cochran)
authors.forename: Elaine K
authors.initials: EK
authors.lastname: Cochran
authors.affiliation: Diabetes Network, Inc, Albuquerque, New Mexico (Ms Valentine)
authors.forename: Virginia
authors.initials: V
authors.lastname: Valentine
authors.affiliation: St Vincent’s Hospital, Indianapolis, Indiana (Dr Samaan)
authors.forename: Karen H
authors.initials: KH
authors.lastname: Samaan
authors.affiliation: Lilly USA, LLC, Indianapolis, Indiana (Ms Corey, Dr Jackson)
authors.forename: Ilene B
authors.initials: IB
authors.lastname: Corey
authors.affiliation: Lilly USA, LLC, Indianapolis, Indiana (Ms Corey, Dr Jackson)
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Jackson
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D037001:Directive Counseling; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D007279:Injections, Subcutaneous / Q000379:methods*; D007328:Insulin / Q000008:administration & dosage; D061386:Insulin, Regular, Human / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D010353:Patient Education as Topic; D017060:Patient Satisfaction; D012307:Risk Factors; D012648:Self Care / Q000379:methods*; D013594:Syringes / Q000706:statistics & numerical data*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D061386:Insulin, Regular, Human; C517652:hemoglobin A1c protein, human