title: Modular access to N-substituted cis-3,5-diaminopiperidines.
abstract: A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.
authors.affiliation: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Faculté des Sciences Fondamentales et Biomédicales, UMR8601, CNRS-Paris Descartes University , 45 rue des Saints Pères, 75006 Paris, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Blond
authors.forename: Paul
authors.initials: P
authors.lastname: Dockerty
authors.forename: Raquel
authors.initials: R
authors.lastname: Álvarez
authors.forename: Serge
authors.initials: S
authors.lastname: Turcaud
authors.forename: Thomas
authors.initials: T
authors.lastname: Lecourt
authors.forename: Laurent
authors.initials: L
authors.lastname: Micouin
mesh_terms: D000586:Amination; D006834:Hydrazines / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006834:Hydrazines; D010880:Piperidines