title: Nori- and sea spaghetti- but not wakame-restructured pork decrease the hypercholesterolemic and liver proapototic short-term effects of high-dietary cholesterol consumption.
abstract: Restructured pork (RP) enriched in Seaweeds are potential functional foods. The antiapoptotic and hypocholesterolemic effects of consuming cholesterol enriched diets containing Wakame-RP (CW), Nori-RP (CN) and Sea Spaghetti (CS) were tested in a 1-wk study. Groups of six rats per group were fed a mix of 85% AIN-93M rodent-diet containing cholesterol and cholic acid as a cholesterol rising agent plus 15% RP containing alga. These diets were compared to control-RP diets enriched or not in cholesterol (CC and C, respectively). After 1-wk, cholesterol feeding significantly increased liver apoptosis markers which were significantly reduced by CS (cellular cycle DNA, caspase-3, and cytochrome c), CN (caspase-3 and cytochrome c) and CW (caspase-3) diets. CN and CS diets significantly blocked the cholesterolaemic rising effect observed in the CC group but no protective effect was observed in the CW group. Differences in seaweed composition added to RP appear responsible for blocking or not the proapoptotic and hypercholesterolemic effects of high cholesterol-RP consumption; thus, any generalization on seaweed effects or food containing seaweeds must be avoided. Although present results are worthy, future studies are demanded to ascertain the utility of consuming algal-RP as part of usual diets.
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición). Facultad de Farmacia. Universidad Complutense de Madrid. Madrid. Spain.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Schultz Moreira
authors.forename: Juana
authors.initials: J
authors.lastname: Benedi
authors.forename: Sara
authors.initials: S
authors.lastname: Bastida
authors.forename: Isabel
authors.initials: I
authors.lastname: Sánchez-Reus
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
mesh_terms: D000818:Animals; D017209:Apoptosis; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004032:Diet; D055951:Functional Food; D006937:Hypercholesterolemia / Q000517:prevention & control; D008099:Liver / Q000473:pathology; D008460:Meat; D044664:Porphyra; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D013997:Time Factors; D044648:Undaria
chemical_list: D002791:Cholesterol, Dietary