title: Low-density lipoprotein as a biomarker for the mobilization of hematopoietic stem cells in peripheral blood.
abstract: The predictor of hematopoietic stem cells (HSCs) mobilized in peripheral blood (PB) remains unknown. We retrospectively examined the relationship between serum cholesterol level and CD34-positive cells mobilized with granulocyte stimulating factor in PB. PB- mobilized CD34-positive cells were significantly higher in patients with high titers of total cholesterol and low-density lipoprotein cholesterol (LDL-C) than in patients with normal levels (average total cholesterol, 122.94 vs. 51.03/μL, p<0.05; average LDL-C 130.07 vs. 53.77, p<0.05). Multivariable analysis showed that LDL-C significantly influenced PB-mobilized CD34-positive cells, suggesting that LDL-C may be an effective biomarker for mobilization of HSCs in PB.
authors.affiliation: Central of Clinical Laboratory, Shimane University Hospital, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishihara
authors.forename: Seiji
authors.initials: S
authors.lastname: Mishima
authors.forename: Rumi
authors.initials: R
authors.lastname: Kodama
authors.forename: Isao
authors.initials: I
authors.lastname: Yoshino
authors.forename: Erika
authors.initials: E
authors.lastname: Adachi
authors.forename: Tamiko
authors.initials: T
authors.lastname: Suyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Taketani
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019172:Transplantation Conditioning / Q000379:methods; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D002784:Cholesterol
keywords: Cholesterol; Hematopoietic stem cell; LDL; Mobilization; PBSCH