title: Conformational studies of chemotactic HCO-Met-Leu-Phe-OMe analogues.
abstract: In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.
authors.affiliation: Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17/19, I-44100, Ferrara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vertuani
authors.forename: M
authors.initials: M
authors.lastname: Boggian
authors.forename: A
authors.initials: A
authors.lastname: Breveglieri
authors.forename: G
authors.initials: G
authors.lastname: Cavicchioni
authors.forename: S
authors.initials: S
authors.lastname: Spisani
authors.forename: A
authors.initials: A
authors.lastname: Scatturin