title: Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC).
abstract: Lead exposure in children is one component leading to cognitive impairment. The Treatment of Lead-Exposed Children Trial (1994-2004) studied the effect of succimer in treating low levels of lead exposure (20-44 mcg/dL) in children 12 to 33 months old. While succimer was effective in reducing blood lead concentrations in the short term, treatment of blood lead levels did not result in any detectable improvement in a wide variety of measurements of cognitive or behavioral function. Furthermore, blood lead concentrations were not distinguishable between chelated and non-chelated individuals at 1 year. The most important treatment strategy is identification and termination of major sources of lead exposure.
authors.affiliation: Division of Medical Toxicology, Department of Emergency Medicine, Hartford Hospital/University of Connecticut School of Medicine, American College of Medical Toxicology, 10645 N. Tatum Blvd. Suite 200-111, Phoenix, AZ, 85028, USA, Charles.McKay@hhchealth.org.
authors.forename: Charles A
authors.initials: CA
authors.lastname: McKay
mesh_terms: D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D002614:Chelating Agents / Q000627:therapeutic use*; D015913:Chelation Therapy; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000187:drug effects; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D020264:Lead Poisoning, Nervous System, Childhood / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008297:Male; D016032:Randomized Controlled Trials as Topic; D004113:Succimer / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D002614:Chelating Agents; D007854:Lead; D004113:Succimer