title: Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.
abstract: A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines.
authors.affiliation: Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Blane P
authors.initials: BP
authors.lastname: Zavesky
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Babij
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fritz
authors.forename: John P
authors.initials: JP
authors.lastname: Wolfe
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006146:Guanidines; D010165:Palladium