title: [Comparison of traumatic related index in serum between minimally invasive and open transforaminal lumbar interbody fusion for tissue injury].
abstract: OBJECTIVE
  To compare the difference of traumatic related index in serum and its significance between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open TLIF.
  
  
  METHODS
  Sixty patients were enrolled by the entry criteria between May and November 2012, and were divided into MIS-TLIF group (n = 30) and open TLIF group (n = 30). There was no significant difference in gender, age, type of lesions, disease segment, and disease duration between 2 groups (P > 0.05). The operation time, intraoperative blood loss, and postoperative hospitalization time were recorded, and the pain severity of incision was evaluated by visual analog scale (VAS). The serum levels of C-reactive protein (CRP) and creatine kinase (CK) were measured at preoperation and at 24 hours postoperatively. The levels of interleukin 6 (IL-6), IL-10, and tumor necrosis factor alpha (TNF-alpha) in serum were measured at preoperation and at 2, 4, 8, and 24 hours after operation.
  
  
  RESULTS
  The operation time, intraoperative blood loss, and postoperative hospitalization time of MIS-TLIF group were significantly smaller than those of open TLIF group (P < 0.05), and the VAS score for incision pain in MIS-TLIF group was significantly lower than that of open TLIF group at 1, 2, and 3 days after operation (P < 0.05). The levels of CRP, CK, IL-6, and IL-10 in MIS-TLIF group were significantly lower than those in open TLIF group at 24 hours after operation (P < 0.05), but there was no significant difference between 2 groups before operation (P > 0.05). No significant difference was found in TNF-alpha level between 2 groups at pre- and post-operation (P > 0.05).
  
  
  CONCLUSIONS
  Compared with the open-TLIF, MIS-TLIF may significantly reduce tissue injury and systemic inflammatory reactions during the early postoperative period.
authors.affiliation: Department of Orthopedics, Affiliated Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, P R China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zou
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Wenqi
authors.initials: W
authors.lastname: Pan
authors.forename: Yong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001863:Bone Screws; D016025:Bone Transplantation; D002097:C-Reactive Protein / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D016207:Cytokines / Q000097:blood; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000097:blood / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D010147:Pain Measurement; D013123:Spinal Fusion / Q000009:adverse effects / Q000379:methods*; D013130:Spinal Stenosis / Q000097:blood / Q000601:surgery; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D002097:C-Reactive Protein; D003402:Creatine Kinase