title: Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study.
abstract: Multiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing-remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS.
authors.affiliation: Neuroscience Institute, Virginia Mason Medical Center, Seattle, WA, USA.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kita
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fox
authors.forename: J Theodore
authors.initials: JT
authors.lastname: Phillips
authors.forename: Michael
authors.initials: M
authors.lastname: Hutchinson
authors.forename: Eva
authors.initials: E
authors.lastname: Havrdova
authors.forename: Sujata P
authors.initials: SP
authors.lastname: Sarda
authors.forename: Sonalee
authors.initials: S
authors.lastname: Agarwal
authors.forename: Jessica
authors.initials: J
authors.lastname: Kong
authors.forename: Annie
authors.initials: A
authors.lastname: Zhang
authors.forename: Vissia
authors.initials: V
authors.lastname: Viglietta
authors.forename: Sarah I
authors.initials: SI
authors.lastname: Sheikh
authors.forename: Emily
authors.initials: E
authors.lastname: Seidman
authors.forename: Katherine T
authors.initials: KT
authors.lastname: Dawson
mesh_terms: D000328:Adult; D000069462:Dimethyl Fumarate; D004311:Double-Blind Method; D005260:Female; D005650:Fumarates / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D005650:Fumarates; D007166:Immunosuppressive Agents; D000069462:Dimethyl Fumarate
keywords: BG-12; Multiple sclerosis; dimethyl fumarate; glatiramer acetate; quality of life; randomized controlled trial; relapsing–remitting