title: [Occupational acute dimethylformamide poisoning: an analysis of 16 cases].
abstract: OBJECTIVE
  To analyze the clinical features and diagnostic points of occupational acute dimethylformamide (DMF) poisoning and to explore the mechanism of occupational acute DMF poisoning.
  
  
  METHODS
  A comprehensive analysis was performed on the clinical data of 16 cases of occupational acute DMF poisoning, including symptoms, signs, and laboratory testing results.
  
  
  RESULTS
  The main clinical features of occupational acute DMF poisoning were digestive system impairments, especially abdominalgia. Hemorrhagic gastroenteritis was not found by gastroscopy. There was no significant correlation between the degree of abdominalgia and alanine aminotransferase level (r(s) = 0.109, P>0.05).
  
  
  CONCLUSIONS
  Abdominalgia is recommended to be one of the reference indices for the diagnosis and degrading of occupational acute DMF poisoning, The mechanism of DMF poisoning remains unclear but it is considered to be related to methyl isocyanate, the intermediate product of DMF metabolism.
authors.affiliation: Department of Occupational Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Jian-shu
authors.initials: JS
authors.lastname: Huang
authors.forename: Xiu-ju
authors.initials: XJ
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Yuan-ling
authors.initials: YL
authors.lastname: Zhou
authors.forename: Peng-qin
authors.initials: PQ
authors.lastname: Liao
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Wang
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000410:Alanine Transaminase / Q000378:metabolism; D004126:Dimethylformamide / Q000506:poisoning*; D006801:Humans; D016273:Occupational Exposure; D012997:Solvents / Q000506:poisoning*
chemical_list: D012997:Solvents; D004126:Dimethylformamide; D000410:Alanine Transaminase