title: Comparision of effects of rosuvastatin versus atorvastatin treatment on plasma levels of asymmetric dimethylarginine in patients with hyperlipidemia having coronary artery disease.
abstract: Elevated plasma levels of asymmetric dimethylarginine (ADMA) are prevalent in patients with hypercholesterolemia and coronary artery disease. A total of 83 patients with hypercholesterolemia and angiographically documented mild coronary artery stenosis were randomized to rosuvastatin treatment (20 mg) or atorvastatin treatment (40 mg) once daily for 6 weeks after a 4-week dietary lead-in phase. Both statins decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels effectively. Only rosuvastatin increased high-density lipoprotein cholesterol (HDL-C) levels. Both rosuvastatin and atorvastatin decreased plasma ADMA levels; rosuvastatin had a significantly greater effect. The reduction in ADMA levels were correlated with the reduction in TC and LDL-C levels as well as LDL-C-HDL-C ratio. Treatment with rosuvastatin or atorvastatin in patients with hyperlipidemia with mild coronary artery stenosis may lead to a decrease in ADMA levels, which may contribute to improved endothelial function.
authors.affiliation: Department of Cardiology, Elazıg Training and Research Hospital, Elazığ, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kurtoglu
authors.affiliation: Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey drsevketb@gmail.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Cardiology, Gaziantep State Hospital, Gaziantep, Turkey.
authors.forename: Isa
authors.initials: I
authors.lastname: Sincer
authors.affiliation: Department of Cardiology, Elazıg Training and Research Hospital, Elazığ, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Altas
authors.affiliation: Department of Cardiology, Marmara University Medical School, Istanbul, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Atas
authors.affiliation: Department of Cardiology, Elazıg Training and Research Hospital, Elazığ, Turkey.
authors.forename: Mucahid
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, Firat University Medical School, Elazığ, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Department of Cardiology, Elazıg Training and Research Hospital, Elazığ, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Erdem
authors.affiliation: Department of Cardiology, Adiyaman University Medical School, Adiyaman, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Akturk
authors.affiliation: Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Emergency Medicine, Elazıg Training and Research Hospital, Elazığ, Turkey.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Can
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D000069059:Atorvastatin; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D015536:Down-Regulation; D005260:Female; D005464:Fluorobenzenes / Q000627:therapeutic use*; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011743:Pyrimidines / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D000068718:Rosuvastatin Calcium; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D015415:Biomarkers; D005464:Fluorobenzenes; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; C018524:N,N-dimethylarginine; D000068718:Rosuvastatin Calcium; D001120:Arginine; D000069059:Atorvastatin
keywords: asymmetric dimethylarginine; atorvastatin; coronary artery disease; hypercholesterolemia; rosuvastatin