title: Serum ferritin level is higher in poorly controlled patients with type 2 diabetes and people without diabetes, aged over 55 years.
abstract: OBJECTIVE
  Diabetes mellitus has been increasing in Mongolia. There is also growing concern about the relationship between iron stores and the severity of type 2 diabetes. In this study, we aimed to evaluate serum ferritin level among Mongolian individuals with and without diabetes.
  
  
  METHODS
  Of 254 participants, a total of 99 previously diagnosed patients with type 2 diabetes and the same numbers of subjects without diabetes were enrolled and invited to a physical examination (BMI, central obesity, blood pressure) and fasting blood tests (fasting blood glucose, HbA1c , serum ferritin, C-reactive protein, aspartate aminotransferase, alanine transferase).
  
  
  RESULTS
  Serum ferritin was higher in the patients with type 2 diabetes compared with the control group without diabetes, with a significant difference in the female groups (341.6 ± 67.2 and 159.1 ± 36.8 ng/ml respectively, P = 0.019). Of the patients with type 2 diabetes, 43.4% had hyperferritinaemia, and 21.2% of the individuals without diabetes had hyperferritinaemia. In the group with type 2 diabetes, serum ferritin level was significantly higher in the group of women whose HbA1c was ≥ 53 mmol/mol (7.0%) compared with the other group of women whose HbA1c was < 53 mmol/mol (7.0%) (562.1 ± 122.1 and 220.5 ± 78.7 ng/ml respectively, P = 0.025). We also found that the subjects without diabetes, aged over 55 years, are at risk of increased serum ferritin.
  
  
  CONCLUSIONS
  Poorly controlled patients with type 2 diabetes and people without diabetes of over 55 years of age are likely to be at a higher risk of developing hyperferritinaemia. Thus, regular assessments of serum ferritin might be important for those who are at risk of hyperferritnaemia for prevention and an early intervention.
authors.affiliation: Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Batchuluun
authors.forename: T
authors.initials: T
authors.lastname: Matsumata
authors.forename: B
authors.initials: B
authors.lastname: Batchuluun
authors.forename: N
authors.initials: N
authors.lastname: Erdenebileg
authors.forename: G
authors.initials: G
authors.lastname: Tsagaantsooj
authors.forename: K
authors.initials: K
authors.lastname: Boldbaatar
authors.forename: A
authors.initials: A
authors.lastname: Khasag
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D019190:Iron Overload / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008986:Mongolia / Q000453:epidemiology
chemical_list: D005293:Ferritins; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human