title: [Acute myeloid leukemia with t(11;12)(p15;q13) translocation: two cases report and literature review].
abstract: OBJECTIVE
  To investigate the clinical and laboratory features of acute myeloid leukemia (AML) with t(11;12)(p15;q13) translocation.
  
  
  METHODS
  Two cases of AML with t(11;12)(p15;q13) translocation were reported and the related literatures were reviewed.
  
  
  RESULTS
  The diagnosis of AML-M3 was supported by morphological, cytochemical staining and electron microscope tests. A rare t(11;12)(p15;q13) translocation, but not classical t(15;17)(q22;q12) translocation and PML- RARα fusion gene, was detected in both cases. Both of the patients were refractory to differentiation induction therapy such as retinoic acid and arsenic trioxide.
  
  
  CONCLUSIONS
  AML is a group of heterogeneous disease derived from hematopoietic stem cell. Cytogenetic characteristic is important for diagnosis, prognosis stratification and therapy selection. Because of the heterogeneity of clinical and molecular features, it is unsuitable to classify AML with t(11;12)(p15;q13) as AML with recurrent cytogenetic aberration. This group of disease may benefit from allogeneic hematopoietic stem cell transplantation.
authors.affiliation: State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Ben-fa
authors.initials: BF
authors.lastname: Gong
authors.forename: Qi-hui
authors.initials: QH
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wei
authors.forename: Jin-yu
authors.initials: JY
authors.lastname: Wang
authors.forename: Xing-li
authors.initials: XL
authors.lastname: Zhao
authors.forename: Dong
authors.initials: D
authors.lastname: Lin
authors.forename: Cheng-wen
authors.initials: CW
authors.lastname: Li
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: Liu
authors.forename: Ying-Chang
authors.initials: YC
authors.lastname: Mi
authors.forename: Jian-xiang
authors.initials: JX
authors.lastname: Wang
mesh_terms: D059786:Abnormal Karyotype; D000293:Adolescent; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic