title: Regulatory T cells use "Itch" to control asthma.
abstract: Regulatory T cells (Tregs) control type 2 T helper cell-mediated (Th2-mediated) lung inflammation, but the molecular mechanisms by which Tregs execute this activity remain elusive. In this issue of the JCI, Jin et al. reveal that Itch, a HECT-type E3 ubiquitin ligase in Tregs, plays a specific role in restraining Th2 cell responses. This finding has important implications for understanding the pathogenesis of allergy and asthma.
authors.forename: WanJun
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D007249:Inflammation / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology* / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*
chemical_list: C471637:Itch protein, mouse; D044767:Ubiquitin-Protein Ligases