title: Non-contact in vivo diffuse optical imaging using a time-gated scanning system.
abstract: We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy- and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.
authors.affiliation: Physikalisch-Technische Bundesanstalt (PTB), Abbestr. 2-12, 10587, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Mazurenka
authors.forename: L
authors.initials: L
authors.lastname: Di Sieno
authors.forename: G
authors.initials: G
authors.lastname: Boso
authors.forename: D
authors.initials: D
authors.lastname: Contini
authors.forename: A
authors.initials: A
authors.lastname: Pifferi
authors.forename: A Dalla
authors.initials: AD
authors.lastname: Mora
authors.forename: A
authors.initials: A
authors.lastname: Tosi
authors.forename: H
authors.initials: H
authors.lastname: Wabnitz
authors.forename: R
authors.initials: R
authors.lastname: Macdonald
keywords: (120.3890) Medical optics instrumentation; (170.3880) Medical and biological imaging; (170.5280) Photon migration; (170.6510) Spectroscopy, tissue diagnostics; (170.6920) Time-resolved imaging