title: Suppressible alleles in a wide domain regulatory gene in Aspergillus nidulans.
abstract: The areA gene of Aspergillus nidulans is a one of the better studied eukaryotic wide domain regulatory genes, necessary for the expression of most structural genes involved in the utilization of a wide variety of nitrogen sources (Arst and Cove 1973; Arst 1983). Here we report the isolation and properties of areA alleles suppressible by translational suppressors (Roberts et al. 1979). Thus we show formally that the areA gene specifies a protein rather than an RNA product and we show that it is possible to generate by external suppression areA gene products with modified properties.
authors.affiliation: Department of Biology, University of Essex, Wivenhoe Park, Colchester, C04 3SQ, Essex, England.
authors.forename: N M
authors.initials: NM
authors.lastname: Al Taho
authors.forename: H M
authors.initials: HM
authors.lastname: Sealy-Lewis
authors.forename: C
authors.initials: C
authors.lastname: Scazzocchio