title: Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1.
abstract: Cu(I) binding promotes the platination of Atox1, although cisplatin binds to the copper coordination sites. In addition, Cu(I) binding enhances the competition of Atox1 with DTT in the reaction of cisplatin. These results indicate that cuprous ions could regulate the cellular trafficking of cisplatin.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China. liuyz@ustc.edu.cn.
authors.forename: Zhaoyong
authors.initials: Z
authors.lastname: Xi
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Changlin
authors.initials: C
authors.lastname: Tian
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wang
authors.forename: Yangzhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002945:Cisplatin / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D000079922:Copper Transport Proteins; D006801:Humans; D056511:Metallochaperones / Q000737:chemistry*; D018832:Molecular Chaperones; D011485:Protein Binding
chemical_list: C474500:ATOX1 protein, human; D056831:Coordination Complexes; D000079922:Copper Transport Proteins; D056511:Metallochaperones; D018832:Molecular Chaperones; C042514:cuprous ion; D003300:Copper; D002945:Cisplatin