title: Dietary and inhalation exposure to polycyclic aromatic hydrocarbons and urinary excretion of monohydroxy metabolites--a controlled case study in Beijing, China.
abstract: Daily dietary and inhalation exposures to 16 parent polycyclic aromatic hydrocarbons (PAHs) and urinary excretion of 13 monohydroxy metabolites (OHPAHs) were monitored for 12 non-smoking university students in Beijing, China, during a controlled feeding experiment. The relationship between the urinary excretion of OHPAHs and the uptake of PAHs was investigated. The results suggest severe exposure of the subjects to PAHs via both dietary and inhalation pathways. Large increase of most urinary OHPAHs occurred after the ingestion of lamb kabob. Higher concentrations of OHPAHs were observed for female subjects, with the intakes of parent PAHs lower than those by males, likely due to the gender differences in metabolism. It appears that besides 1-PYR, metabolites of PHE could also be used as biomarkers to indicate the short-term dietary exposure to PAHs and urinary 3-BaA may serve as the biomarker for inhalation intake of high molecular weight PAHs.
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Junnan
authors.initials: J
authors.lastname: Ding
authors.forename: Guofeng
authors.initials: G
authors.lastname: Shen
authors.forename: Junjun
authors.initials: J
authors.lastname: Zhong
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Siye
authors.initials: S
authors.lastname: Wei
authors.forename: Chaoqi
authors.initials: C
authors.lastname: Chen
authors.forename: Yuanchen
authors.initials: Y
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Huizhong
authors.initials: H
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Huang
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Shu
authors.initials: S
authors.lastname: Su
authors.forename: Nan
authors.initials: N
authors.lastname: Lin
authors.forename: Xilong
authors.initials: X
authors.lastname: Wang
authors.forename: Wenxin
authors.initials: W
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Tao
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D002681:China; D004032:Diet / Q000706:statistics & numerical data*; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D005260:Female; D005506:Food Contamination / Q000032:analysis / Q000706:statistics & numerical data; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis / Q000706:statistics & numerical data; D008297:Male; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons
keywords: Biomarkers; Dietary exposure; Polycyclic aromatic hydrocarbons; Urinary excretion