title: Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs.
abstract: This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study. Pre-treatment lameness grades were 1.2 ± 0.97 for HA + S and 1.8 ± 1.1 for ACP and were not different between groups. Post-treatment lameness grades were 0.4 ± 0.55 for HA + S and 0.8 ± 0.64 for ACP with significant (P < 0.05) improvement with either treatment but without differences between groups. Client-based assessments demonstrated improvements in activity, lameness, and pain with HA + S and ACP. These data suggest that both treatments have beneficial effects for dogs with bilateral elbow OA.
authors.affiliation: Comparative Orthopaedic Laboratory, College of Veterinary Medicine, University of Missouri - Columbia, 379 East Campus Drive, Columbia, Missouri 65211, USA.
authors.forename: Samuel P
authors.initials: SP
authors.lastname: Franklin
authors.forename: James L
authors.initials: JL
authors.lastname: Cook
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004311:Double-Blind Method; D005552:Forelimb / Q000473:pathology; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D010949:Plasma; D055675:Viscosupplements / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D055675:Viscosupplements; D006820:Hyaluronic Acid; D008775:Methylprednisolone