title: Nylon-3 polymers that enable selective culture of endothelial cells.
abstract: Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomaterials-based approaches to tissue repair or regeneration. However, there are very few examples of synthetic materials that display selectivity in supporting cell growth. We describe nylon-3 polymers that support in vitro culture of endothelial cells but do not support the culture of smooth muscle cells or fibroblasts. These materials may be promising for vascular biomaterials applications.
authors.forename: Runhui
authors.initials: R
authors.lastname: Liu
authors.forename: Xinyu
authors.initials: X
authors.lastname: Chen
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Gellman
authors.forename: Kristyn S
authors.initials: KS
authors.lastname: Masters
mesh_terms: D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009757:Nylons / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D009757:Nylons