title: Synthesis and characterization of some metal complexes of a proton transfer salt, and their inhibition studies on carbonic anhydrase isozymes and the evaluation of the results by statistical analysis.
abstract: A novel proton transfer compound (HMeOABT)(+) (HDPC)(-) (1) and its Fe(III), Co(II), Ni(II) and Cu(II) complexes (2-5) have been prepared and characterized by spectroscopic techniques. Complex 4 has distorted octahedral conformation revealed by single crystal X-ray diffraction method. Structures of the other complexes might be proposed as octahedral according to experimental data. All compounds were also evaluated for their in vitro inhibition effects on hCA I and II for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA I and II. Data have been analyzed by using a one-way analysis of variance. The comparison of the inhibition studies of 1-5 to parent compounds indicates that 1-5 have superior inhibitory effects. The inhibition effects of 2-5 are also compared to inhibitory properties of the metal complexes of MeOABT and H2DPC, revealing an improved transfection profile.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Dumlupınar University , Kütahya , Turkey .
authors.forename: Halil
authors.initials: H
authors.lastname: Ilkimen
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yenikaya
authors.forename: Musa
authors.initials: M
authors.lastname: Sarı
authors.forename: Metin
authors.initials: M
authors.lastname: Bülbül
authors.forename: Melike
authors.initials: M
authors.lastname: Aslan
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Süzen
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D019216:Metals, Heavy / Q000737:chemistry; D008958:Models, Molecular; D015233:Models, Statistical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010848:Picolinic Acids / Q000737:chemistry; D011522:Protons; D012492:Salts / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D052160:Benzothiazoles; D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D019216:Metals, Heavy; D009942:Organometallic Compounds; D010848:Picolinic Acids; D011522:Protons; D012492:Salts; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II; C004860:dipicolinic acid
keywords: 2,6-pyridinedicarboxylic acid; 2-Amino-6-methoxybenzothiazole; carbonic anhydrase; inhibition; proton transfer