title: Effect of pressure on the stability of G-quadruplex DNA: thermodynamics under crowding conditions.
abstract: Under pressure: A DNA G-quadruplex was unfolded under high pressure, but crowding conditions repressed this effect owing to enthalpic contributions. Volumetric analysis showed that ethylene glycol or poly(ethylene glycol) decreased the volume change of the transition by more than fourfold owing to the alteration of the number and/or radii of hydrating water molecules.
authors.affiliation: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University (Japan).
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D013816:Thermodynamics
chemical_list: D004247:DNA
keywords: DNA structures; G-quadruplexes; gene expression; high pressure; thermodynamics