title: Nucleophile-catalyzed, facile, and highly selective C-H activation of fluoroform with Pd(II).
abstract: Exceedingly facile (23 °C) and chemoselective H-CF3 activation with [(dppp)Pd(Ph)(OH)] in the presence of a Lewis base promoter such as n-Bu3P leads to Pd-CF3 bond formation in nearly quantitative yield. A combined experimental and computational study points to a new mechanism that involves H-bonding Pd-O(H)···H-CF3 and nucleophilic attack of the promoter on the metal, followed by a push-pull-type collapse of the resultant five-coordinate Pd(II) intermediate via a polar transition state.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Tarragona 43007, Spain.
authors.forename: Shin
authors.initials: S
authors.lastname: Takemoto
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Grushin