title: SNPs of MYPN and TTN genes are associated to meat and carcass traits in Italian Large White and Italian Duroc pigs.
abstract: Myopalladin (MYPN) and titin (TTN) play key roles in skeletal muscle structural organisation and for this reason they may be functional candidates for meat production traits in pigs. We analysed by PCR-RFLP two polymorphisms previously identified and described in the 3'UTR of MYPN and TTN genes in a group of Italian Large White (ILW) and Italian Duroc (ID) pigs with extreme divergent estimated breeding values for some production traits. Significant allele frequency differences were observed for lean cuts (LC) at the MYPN locus in ILW breed and for visible intermuscular fat (VIF) at MYPN and TTN loci in ID breed. Moreover, association analysis between the two genes and some production traits (average daily gain, LC, backfat thickness, ham weight, feed conversion ratio and VIF) was performed in a sample of 409 ILW and 381 ID pigs. On the whole, the results showed significant effects of both genes on some of the considered traits in ID breed, and for TTN gene in ILW animals. These results indicate that both genes can be considered as candidates for meat and carcass traits in ID pigs.
authors.affiliation: Department of Agricultural and Food Science, DISTAL, University of Bologna, Via F.lli Rosselli 107, 42123, Reggio Emilia, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Braglia
authors.forename: Roberta
authors.initials: R
authors.lastname: Davoli
authors.forename: Andrea
authors.initials: A
authors.lastname: Zappavigna
authors.forename: Paolo
authors.initials: P
authors.lastname: Zambonelli
authors.forename: Luca
authors.initials: L
authors.lastname: Buttazzoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gallo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Russo
mesh_terms: D000818:Animals; D001947:Breeding; D064211:Connectin / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005838:Genotype; D007558:Italy; D008460:Meat; D009124:Muscle Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D064211:Connectin; D009124:Muscle Proteins