title: The primary extra-gastrointestinal stromal tumor of pleura: a case report and a literature review.
abstract: The gastrointestinal stromal tumor is the most common mesenchymal neoplasm of the gastrointestinal tract. The gastrointestinal stromal tumor universally expresses KIT and DOG-1 and frequently harbors oncogenic mutations in the KIT gene. While the gastrointestinal stromal tumor usually arises in the alimentary tract, it is rarely found in the extragastrointestinal area. When it is, it is called an extragastrointestinal stromal tumor. Although the pathogenesis, prognostic factors and outcomes of gastrointestinal stromal tumors are well known, those of extragastrointestinal stromal tumors have not been fully studied. We report, herein, a unique primary extragastrointestinal stromal tumor from the pleura in a 73-year-old woman who presented with pleural mass. The extragastrointestinal stromal tumor was surgically resected and confirmed by means of an immunohistochemical study and a molecular analysis.
authors.affiliation: *Department of Pathology, Hanyang University Seoul Hospital, Seoul, Korea; 222 Wangsimni 2-dong, Seongdong-gu, Seoul 133-792, Korea. sspaik@hanyang.ac.kr.
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Yi
authors.forename: Jongmin
authors.initials: J
authors.lastname: Sim
authors.forename: Byeong-Bae
authors.initials: BB
authors.lastname: Park
authors.forename: Young Yiul
authors.initials: YY
authors.lastname: Lee
authors.forename: Won Sang
authors.initials: WS
authors.lastname: Jung
authors.forename: Hyo-Jun
authors.initials: HJ
authors.lastname: Jang
authors.forename: Tae Kyung
authors.initials: TK
authors.lastname: Ha
authors.forename: Seung Sam
authors.initials: SS
authors.lastname: Paik
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: DOG-1; KIT; Thoracic-Mediastinum; gastrointestinal stromal tumor; pleura; pleural cavity