title: Involvement of microRNA-198 overexpression in the poor prognosis of esophageal cancer.
abstract: OBJECTIVE
  This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer.
  
  
  METHODS
  MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined.
  
  
  RESULTS
  MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P < 0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P = 0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P = 0.014), tumor length (P = 0.040) and expression (P = 0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively.
  
  
  CONCLUSIONS
  miR- 198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.
authors.affiliation: Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China E-mail : zhaobscn@126.com, wtianyuncn@126.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Qi
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Yao
authors.forename: Bao-Sheng
authors.initials: BS
authors.lastname: Zhao
authors.forename: Xiu-Guang
authors.initials: XG
authors.lastname: Qin
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Wen-Ju
authors.initials: WJ
authors.lastname: Wang
authors.forename: Tian-Yun
authors.initials: TY
authors.lastname: Wang
authors.forename: Shang-Guo
authors.initials: SG
authors.lastname: Liu
authors.forename: Han-Chen
authors.initials: HC
authors.lastname: Li
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C535221:MIRN198 microRNA, human; D035683:MicroRNAs