title: Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy?
abstract: Statins (hydroxymethylglutaryl-coenzyme-A reductase inhibitors) are first-line agents for the management of hyperlipidemia in patients at high risk of cardiovascular (CV) events, and are the most commonly prescribed CV drugs worldwide. Although safe and generally well tolerated, there is growing evidence to suggest that statins are associated with an elevated occurrence of new-onset diabetes mellitus (DM). Recent experimental and clinical data have prompted the US Food and Drug Administration to add information to statin labels regarding the increased risk of development of type 2 DM. The main purpose of this review is to critically discuss the clinical evidence regarding the association of statin use with new-onset DM, the CV benefit/risk ratio with statins, and the rationale for individualized statin therapy.
authors.affiliation: Department of Cardiology and Internal Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Skłodowskiej-Curie Street No 9, 8 094, Bydgoszcz, Poland, eliano.navarese@alice.it.
authors.forename: Eliano Pio
authors.initials: EP
authors.lastname: Navarese
authors.forename: Anna
authors.initials: A
authors.lastname: Szczesniak
authors.forename: Michalina
authors.initials: M
authors.lastname: Kolodziejczak
authors.forename: Bartosz
authors.initials: B
authors.lastname: Gorny
authors.forename: Jacek
authors.initials: J
authors.lastname: Kubica
authors.forename: Harry
authors.initials: H
authors.lastname: Suryapranata
mesh_terms: D000465:Algorithms; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D057285:Precision Medicine; D012306:Risk
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors