title: Within-person coupling of changes in cortisol, testosterone, and DHEA across the day in adolescents.
abstract: We comprehensively examined within-person and between-person associations between cortisol and DHEA and cortisol and testosterone across the day. Data are from a sample of 213 adolescents aged 11-16 (M = 13.7, SD = 1.5 years) from the Northeastern US who were oversampled for psychopathology symptoms. Six repeated measures of hormone levels across 3 days were used to test three specific questions of cortisol-DHEA and cortisol-testosterone associations within individuals (coupling) across the day, and one question of cortisol-DHEA and cortisol-testosterone diurnal slopes were associated between adolescents. Results consistently revealed positive cortisol-DHEA and cortisol-testosterone coupling across the day, often more pronounced in girls relative to boys. Cortisol and DHEA slopes were positively associated, whereas cortisol and testosterone were negatively associated between-adolescents. Findings suggest multiple mechanisms and highlight the multifaceted nature of associations of hormone changes during adolescence and importance of considering both axes for between- and within-person aspects of neuroendocrine development.
authors.affiliation: The Pennsylvania State University, University Park, PA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Marceau
authors.affiliation: The University of Wisconsin-Madison, Madison, WI.
authors.forename: Paula L
authors.initials: PL
authors.lastname: Ruttle
authors.affiliation: The University of New Orleans, New Orleans, LA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Shirtcliff
authors.affiliation: The University of California-Davis, Davis, CA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Hastings
authors.affiliation: The University of Minnesota, Minneapolis, MN.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Klimes-Dougan
authors.affiliation: The University of Wisconsin-Madison, Madison, WI.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Zahn-Waxler
mesh_terms: D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D012463:Saliva / Q000737:chemistry; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D003687:Dehydroepiandrosterone; D006854:Hydrocortisone
keywords: DHEA; cortisol; diurnal; testosterone; within-person coupling