title: [Regulation of intracellular signal pathways via sensor proteins by oxidative stress].
abstract: It has been known that reactive oxygen species (ROS) control the enzymatic and transcriptional activity of proteins via direct modification of cysteine residues. Hence, oxidation of cysteine thiol could be a vital modulator of signal transduction pathways. These findings indicate that some proteins serve as the sensor proteins highly sensitive to ROS. In this review, I show the relationship between intracellular ROS sensor and the regulation of protein function via oxidation.
authors.affiliation: Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
mesh_terms: D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives / Q000502:physiology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2 / Q000502:physiology*; D018384:Oxidative Stress / Q000235:genetics* / Q000502:physiology*; D019704:Protein Disulfide-Isomerases / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D017382:Reactive Oxygen Species; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D017382:Reactive Oxygen Species; C545158:cysteine thiolate; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D017027:Protein Tyrosine Phosphatases; D019704:Protein Disulfide-Isomerases; D003545:Cysteine