title: Novel bioactive amino-functionalized cellulose nanofibers.
abstract: Amino-cellulose-based nanofibers are prepared by electrospinning of blended solutions of 6-deoxy-6-trisaminoethyl-amino (TEAE) cellulose and polyvinyl alcohol (PVA). The TEAE cellulose with a degree of substitution of 0.67 is synthesized via a nucleophilic displacement reaction starting from cellulose-p-toluenesulfonic acid ester. Several solution characteristics such as polymer concentration, electrical conductivity, and surface tension as well as setup parameters are investigated to optimize the ability of nanofiber formation. These parameters are evaluated using the rheological studies of the solutions. The nanofibers obtained are characterized by scanning electron microscopy (SEM) and show a high antimicrobial activity against Staphylococcus aureus and Klebsiella pneumoniae.
authors.affiliation: Center of Excellence for Polysaccharide Research, Thuringian Institute of Textile and Plastics Research e.V., Breitscheidstraße 97, 07407, Rudolstadt, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Roemhild
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wiegand
authors.forename: Uta-Christina
authors.initials: UC
authors.lastname: Hipler
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry*; D004553:Electric Conductivity; D007711:Klebsiella pneumoniae / Q000187:drug effects; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013500:Surface Tension
chemical_list: D000900:Anti-Bacterial Agents; D011142:Polyvinyl Alcohol; D002482:Cellulose
keywords: amino cellulose; antimicrobial activity; electro­spinning; nanofibers