title: Association of GRM7 variants with different phenotype patterns of age-related hearing impairment in an elderly male Han Chinese population.
abstract: Several single nucleotide polymorphisms (SNPs) of the Glutamate metabotrophic receptor 7 gene (GRM7) have recently been identified by the genome-wide association study (GWAS) as potentially playing a role in susceptibility to age-related hearing impairment (ARHI), however this has not been validated in the Han Chinese population. The aim of this study was to determine if these SNPs are also associated with ARHI in an elderly male Han Chinese population. In this case-control candidate genes association study, a total of 982 men with ARHI and 324 normal-hearing controls subjects were studied. Using K-means cluster analysis, four audiogram shape subtypes of ARHI were identified in the case group: ''flat shape (FL)'', ''sloping shape (SL)'', ''2-4 kHz abrupt loss (AL) shape'' and ''8 kHz dip (8D) shape''. Results suggested that the SNP rs11928865 (A>T) of GRM7 was significantly associated with ARHI after adjusting for non-genetic factors (p = 0.000472, OR = 1.599, 95%CI = 1.229~2.081). Furthermore, frequency of TT genotype (rs11928865) were significant higher in the SL subgroup and AL subgroup with compared to controls group (p = 9.41E-05, OR = 1.945, 95%CI = 1.393~2.715; p = 0.000109, OR = 1.915, 95%CI = 1.378~2.661 adjusted, respectively) after Bonferroni correction. However, there wasn't significant difference in the frequency of the TT genotype between cases in the FL subgroup or the 8D subgroup with when compared with controls. Results of the current study suggest that, in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in ARHI patients with SL and AL phenotype patterns.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China ; Ear Institute, Shanghai JiaoTong University School of Medicine, Shanghai, China ; Department of Otolaryngology Head and Neck Surgery, RenJi Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Luo
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Jin
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Pang
authors.forename: Jiping
authors.initials: J
authors.lastname: Li
authors.forename: Yongchuan
authors.initials: Y
authors.lastname: Chai
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Luping
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wu
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xianting
authors.initials: X
authors.lastname: Hu
authors.forename: Jingwen
authors.initials: J
authors.lastname: Sun
authors.forename: Xuemei
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhuping
authors.initials: Z
authors.lastname: Fan
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Huang
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001299:Audiometry; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D056726:Genetic Association Studies; D014644:Genetic Variation; D005838:Genotype; D034381:Hearing Loss / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*
chemical_list: D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7