title: Viral manipulation of cellular protein conjugation pathways: The SUMO lesson.
abstract: Small ubiquitin-like modifier (SUMO)ylation is a key post-translational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.
authors.affiliation: Domenico Mattoscio, Chiara V Segré, Susanna Chiocca, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Mattoscio
authors.forename: Chiara V
authors.initials: CV
authors.lastname: Segré
authors.forename: Susanna
authors.initials: S
authors.lastname: Chiocca
keywords: Exploitation; Immune evasion; Innate immunity; Small ubiquitin-like modifier; Small ubiquitin-like modifier-ylation; Virus; Virus assembly