title: [Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer].
abstract: We have examined for the first time the relationship between the expression of PAPP-A metalloproteinase and insulin-like growth factors (IGF-I, IGF-II, VEGF) and transcription factors (NF-kappaB, HIF-1) playing an important role in pathogenesis of cancer. We also demonstrated a positive association between the level of PAPP-A metalloproteinase and the level of growth (VEGF and IGF-I) and transcription factors (NF-kappaB p50, NF-kappaB p65, HIF-1alpha). The current findings suggest an important role of PAPP-A in regulation of bioavailability of IGF-I, VEGF, activated forms of NF-kappaB, and alpha-subunits of HIF-1 in endometrial tumors.
authors.forename: N V
authors.initials: NV
authors.lastname: Iunusova
authors.forename: L V
authors.initials: LV
authors.lastname: Spirina
authors.forename: L A
authors.initials: LA
authors.lastname: Kondakova
authors.forename: A L
authors.initials: AL
authors.lastname: Kolomiets
authors.forename: A L
authors.initials: AL
authors.lastname: Chernyshova
authors.forename: V D
authors.initials: VD
authors.lastname: Koval'
authors.forename: V V
authors.initials: VV
authors.lastname: Nedosekov
authors.forename: O V
authors.initials: OV
authors.lastname: Savenkova
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D009367:Neoplasm Staging; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D016328:NF-kappa B; D014157:Transcription Factors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human