title: Diet and metabolic syndrome: an overview.
abstract: The metabolic syndrome (MetS) is a complex multifactorial disorder and its incidence is on the increase worldwide. Due to the definitive link between obesity and the MetS weight loss strategies are of prime importance in halting the spread of MetS. Numerous epidemiological studies provide evidence linking dietary patterns to incidence of MetS symptoms. As a consequence of the epidemiology studies, dietary intervention studies which analyse the effects of supplementing diets with particular nutrients of interest on the symptoms of the MetS have been conducted. Evidence has shown that lifestyle intervention comprising changes in dietary intake and physical activity leads to an improved metabolic profile both in the presence or absence of weight loss thus highlighting the importance of a multi-faceted approach in combating MetS. Nutritional therapy research is not focused solely on reducing energy intake and manipulating macronutrient intake but is investigating the role of functional foods or bioactive components of food. Such bioactives which target weight maintenance and /or insulin sensitivity may have a potentially positive effect on the symptoms of the MetS. However the efficacy of different functional nutrients needs to be further defined and clearly demonstrated.
authors.forename: Deirdre
authors.initials: D
authors.lastname: Keane
authors.forename: Stacey
authors.initials: S
authors.lastname: Kelly
authors.forename: Niamh P
authors.initials: NP
authors.lastname: Healy
authors.forename: Maeve A
authors.initials: MA
authors.lastname: McArdle
authors.forename: Kieran
authors.initials: K
authors.lastname: Holohan
authors.affiliation: Nutrigenomics Research Group, Food for Health Ireland, UCD Conway Institute & UCD Institute of Food and Health, University College Dublin, Dublin 4, Ireland. Helen.roche@ucd.ie.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects / Q000379:methods*; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy* / Q000453:epidemiology; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology; D015431:Weight Loss / Q000502:physiology
chemical_list: D005227:Fatty Acids