title: Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy.
abstract: Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a "Raman signal flip" between the two reporters of the surface-enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.
authors.affiliation: Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, 318 Jolley Hall, 1 Brookings Drive, St. Louis, MO, 63130, USA.
authors.forename: Naveen
authors.initials: N
authors.lastname: Gandra
authors.forename: Christopher
authors.initials: C
authors.lastname: Portz
authors.forename: Srikanth
authors.initials: S
authors.lastname: Singamaneni
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001672:Biocompatible Materials; D001943:Breast Neoplasms / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D017612:Gold Compounds; D006801:Humans; D007834:Lasers; D008027:Light; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules; D018030:Silver Compounds; D013057:Spectrum Analysis; D013059:Spectrum Analysis, Raman; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D017612:Gold Compounds; D053769:Nanocapsules; D018030:Silver Compounds; D004317:Doxorubicin
keywords: SERS probes; core/shell gold nanostructures; drug delivery; laser ablation; locoregional therapy; nanorattles