title: Cerebellar Purkinje cell activity drives motor learning.
abstract: The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.
authors.affiliation: 1] Department of Neurobiology, Stanford School of Medicine, Stanford, California, USA. [2] Department of Molecular and Cellular Physiology, Stanford School of Medicine, Stanford, California, USA. [3].
authors.forename: T D Barbara
authors.initials: TD
authors.lastname: Nguyen-Vu
authors.forename: Rhea R
authors.initials: RR
authors.lastname: Kimpo
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Rinaldi
authors.forename: Arunima
authors.initials: A
authors.lastname: Kohli
authors.forename: Hongkui
authors.initials: H
authors.lastname: Zeng
authors.forename: Karl
authors.initials: K
authors.lastname: Deisseroth
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Raymond
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002531:Cerebellum / Q000166:cytology*; D000075402:Channelrhodopsins; D000229:Dependovirus / Q000235:genetics; D007839:Functional Laterality; D005786:Gene Expression Regulation / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D009154:Mutation / Q000235:genetics; D062308:Optogenetics; D010775:Photic Stimulation; D011689:Purkinje Cells / Q000502:physiology*; D014161:Transduction, Genetic; D014722:Vestibule, Labyrinth / Q000502:physiology
chemical_list: D000075402:Channelrhodopsins; D008164:Luminescent Proteins