title: Integrative neurochemistry and neurobiology of social recognition and behavior analyzed with respect to CD38-dependent brain oxytocin secretion.
abstract: This review summarizes the literature and our own data regarding the role of NAD⁺-glycohydrolase/CD38-controlled molecular mechanisms of hypothalamic and pituitary oxytocin secretion in social behavior regulation. Current approaches to the modulation of both CD38 expression and brain cell activity that represent prospective treatments for disorders associated with altered social behavior are discussed.
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Takara-machi 13-1, Kanazawa, 920-8640, Japan. haruhiro@med.kanazawa-u.ac.jp.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Salmina
authors.forename: Olga
authors.initials: O
authors.lastname: Lopatina
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Kuvacheva
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D009243:NAD / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism*; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior
chemical_list: D009243:NAD; D010121:Oxytocin; D006026:Glycoside Hydrolases; D051997:ADP-ribosyl Cyclase 1