title: GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus.
abstract: We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.
authors.affiliation: 1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA [2] Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sleiman
authors.forename: Dai
authors.initials: D
authors.lastname: Wang
authors.forename: Joseph
authors.initials: J
authors.lastname: Glessner
authors.forename: Dexter
authors.initials: D
authors.lastname: Hadley
authors.forename: Raquel E
authors.initials: RE
authors.lastname: Gur
authors.forename: Nadine
authors.initials: N
authors.lastname: Cohen
authors.forename: Qingqin
authors.initials: Q
authors.lastname: Li
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*