title: Evaluation of a rapid pressor response test in healthy cats.
abstract: OBJECTIVE
  To evaluate angiotensin I and angiotensin II rapid pressor response tests in healthy cats.
  
  
  METHODS
  6 purpose-bred sexually intact male cats.
  
  
  METHODS
  Telemetric blood pressure (BP) implants were placed in all cats. After 2 weeks, cats were anesthetized for challenge with exogenous angiotensin I or angiotensin II. Continuous direct arterial BP was recorded during and immediately after IV administration of boluses of angiotensin I or angiotensin II at increasing doses. Blood pressure responses were evaluated for change in systolic BP (SBP), change in diastolic BP (DBP), and rate of increase of SBP by 4 observers.
  
  
  RESULTS
  Following IV angiotensin I and angiotensin II administration, transient, dose-dependent increases in BP (mean ± SEM change in SBP, 25.7 ± 5.2 and 45.0 ± 9.1; change in DBP, 23.4 ± 4.7 mm Hg and 36.4 ± 7.8 mm Hg; for 100 ng of angiotensin I/kg and angiotensin II/kg, respectively) and rate of increase of SBP were detected. At angiotensin I and II doses < 2.0 ng/kg, minimal responses were detected, with greater responses at doses ranging from 20 to 1,000 ng/kg. A significant effect of observer was not found. No adverse effects were observed.
  
  
  CONCLUSIONS
  The rapid pressor response test elicited dose-dependent, transient increases in SBP and DBP. The test has potential as a means of objectively evaluating the efficacy of various modifiers of the renin-angiotensin-aldosterone system in cats. Ranges of response values are provided for reference in future studies.
authors.affiliation: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
authors.forename: Amanda Erickson
authors.initials: AE
authors.lastname: Coleman
authors.forename: Chad W
authors.initials: CW
authors.lastname: Schmiedt
authors.forename: Tiffany L
authors.initials: TL
authors.lastname: Jenkins
authors.forename: Emily D
authors.initials: ED
authors.lastname: Garber
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Reno
authors.forename: Scott A
authors.initials: SA
authors.lastname: Brown
mesh_terms: D061605:Administration, Intravenous / Q000662:veterinary; D000803:Angiotensin I / Q000008:administration & dosage / Q000378:metabolism*; D000804:Angiotensin II / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D008297:Male; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D000803:Angiotensin I