title: New loci associated with chronic hepatitis B virus infection in Han Chinese.
abstract: Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide association study in Han Chinese populations. The discovery phase included 951 HBV carriers (cases) and 937 individuals who had naturally cleared HBV infection (controls) and was followed by independent replications with a total of 2,248 cases and 3,051 controls and additional replications with 1,982 HBV carriers and 2,622 controls from the general population. We identified two new loci associated with chronic HBV infection: rs3130542 at 6p21.33 (near HLA-C, odds ratio (OR) = 1.33, P = 9.49 × 10(-14)) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 × 10(-12)). Additionally, we replicated the previously identified associations of HLA-DP and HLA-DQ variants at 6p21.32 with chronic HBV infection. These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
authors.affiliation: 1] Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Department of Epidemiology & Biostatistics, Nanjing Medical University, Nanjing, China. [2] State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. [3].
authors.forename: Zhibin
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authors.lastname: Hu
authors.forename: Yao
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authors.lastname: Liu
authors.forename: Xiangjun
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authors.lastname: Zhai
authors.forename: Juncheng
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authors.forename: Guangfu
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authors.lastname: Jin
authors.forename: Li
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authors.forename: Yuan
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authors.lastname: Yang
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authors.forename: Minjie
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authors.lastname: Wen
authors.forename: Kaipeng
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authors.lastname: Xie
authors.forename: Guoming
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authors.lastname: Du
authors.forename: Qungang
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authors.lastname: Wang
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Minquan
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authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yisha
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authors.lastname: He
authors.forename: Ying
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authors.lastname: Wang
authors.forename: Gangqiao
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authors.lastname: Zhou
authors.forename: Weihua
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authors.lastname: Jia
authors.forename: Jiachun
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authors.lastname: Lu
authors.forename: Shengping
authors.initials: S
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhou
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
mesh_terms: D044466:Asian People / Q000235:genetics*; D002353:Carrier State / Q000453:epidemiology; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D015236:HLA-C Antigens / Q000235:genetics*; D006682:HLA-DP Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; C079437:UBE2L3 protein, human; D044763:Ubiquitin-Conjugating Enzymes