title: Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.
abstract: A flow chemistry process for the Oppenauer oxidation of benzylic secondary alcohols using partially hydrated zirconium oxide and a simple carbonyl containing oxidant such as acetone, cyclohexanone, and neopentanal is reported. The heterogeneous oxidative system could be applied to a wide range of functionalized alcohol substrates, allowing clean and fast delivery of ketone products within a few minutes between 40 and 100 °C.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge , Lensfield Road, CB2 1EW, Cambridge, U.K., and Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Chorghade
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Joel M
authors.initials: JM
authors.lastname: Hawkins
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D001592:Benzyl Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D015040:Zirconium; C028541:zirconium oxide