title: Liberate and grab it, ingest and digest it: the GbdR regulon of the pathogen Pseudomonas aeruginosa.
abstract: The compatible solute glycine betaine is a powerful osmostress protectant, but many microorganisms can also use it as a nutrient. K. J. Hampel et al. (J. Bacteriol. 196:7-15, 2014) defined a regulon in the notorious pathogen Pseudomonas aeruginosa that comprises modules for the harvest and import of the glycine betaine biosynthetic precursor choline and its subsequent catabolism to pyruvate. The reported data link the GbdR activator with the metabolism of host-derived compounds (e.g., phosphocholine) and virulence traits of P. aeruginosa.
authors.affiliation: Philipps-University Marburg, Department of Biology, Laboratory for Microbiology, Marburg, Germany, and LOEWE-Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
authors.forename: Erhard
authors.initials: E
authors.lastname: Bremer
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D018085:Regulon; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors