title: Anti-yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung.
abstract: Purkinje cell cytoplasmic antibody type 1 (PCA-1), or anti-Yo, is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration (PCD). The vast majority of cases of anti-Yo PCD, however, occur in females over 60 years old and are associated with gynecologic tumors. Only 10 cases have been reported in males, and only 2 were associated with cancer of the lung. Here we describe the youngest known case of PCA-1 positive PCD in a male, whose lung tumor was undetectable even on FDG-PET.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Hasadsri
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: Bonnie H
authors.initials: BH
authors.lastname: Wang
authors.forename: Lalitha
authors.initials: L
authors.lastname: Yekkirala
authors.forename: Mingtao
authors.initials: M
authors.lastname: Wang