title: Body composition analysis by air displacement plethysmography in normal weight to extremely obese adults.
abstract: OBJECTIVE
  To compare body composition parameters estimated by air displacement plethysmography (ADP) to dual X-ray absorptiometry (DXA) in body mass index (BMI) classifications that include extremely obese (BMI ≥ 40.0 kg/m(2) ), and to examine if differences between analyses were influenced by BMI.
  
  
  METHODS
  Fat-free mass (FFM, kg), fat mass (FM, kg), and body fat (BF, %) were analyzed with both technologies.
  
  
  RESULTS
  All outcome measures of ADP and DXA were highly correlated (r ≥ 0.95, P < 0.001 for FFM, FM, and BF), but Bland-Altman analyses revealed significant bias (P < 0.01 for all). ADP estimated greater FFM and lower FM and BF (P < 0.01 for all). BMI explained 27% of the variance in differences between FFM measurements (P < 0.001), and 37 and 33% of the variances in differences between FM and BF measurements, respectively (P < 0.001 for both). Within normal weight and overweight classifications, ADP estimated greater FFM and lower FM and BF (P < 0.001 for all), but the opposite occurred within the extremely obese classification; ADP estimated lower FFM and greater FM and BF (P < 0.05 for all).
  
  
  CONCLUSIONS
  Body composition analyses by the two technologies were strongly congruent, but systematically different and influenced by BMI. Caution should be taken when utilizing ADP to estimate body composition parameters over a wide range of BMI classifications that include extremely obese.
authors.affiliation: Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Kazanna C
authors.initials: KC
authors.lastname: Hames
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Anthony
authors.forename: John C
authors.initials: JC
authors.lastname: Thornton
authors.forename: Dympna
authors.initials: D
authors.lastname: Gallagher
authors.forename: Bret H
authors.initials: BH
authors.lastname: Goodpaster
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition; D001835:Body Weight / Q000502:physiology*; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology / Q000503:physiopathology*; D010991:Plethysmography / Q000379:methods*; D012189:Retrospective Studies; D012720:Severity of Illness Index