title: Photoinitiated polymerization of 2-hydroxyethyl methacrylate by riboflavin/triethanolamine in aqueous solution: a kinetic study.
abstract: The polymerization of 1-3 M 2-hydroxyethyl methacrylate (HEMA) initiated by riboflavin/triethanolamine system has been studied in the pH range 6.0-9.0. An approximate measure of the kinetics of the reaction during the initial stages (~5% HEMA conversion) has been made to avoid the effect of any variations in the volume of the medium. The concentration of HEMA in polymerized solutions has been determined by a UV spectrophotometric method at 208 nm with a precision of ±3%. The initial rate of polymerization of HEMA follows apparent first-order kinetics and the rates increase with pH. This may be due to the presence of a labile proton on the hydroxyl group of HEMA. The second-order rate constants for the interaction of triethanolamine and HEMA lie in the range of 2.36 to 8.67 × 10(-2) M(-1) s(-1) at pH 6.0-9.0 suggesting an increased activity with pH. An increase in the viscosity of HEMA solutions from 1 M to 3 M leads to a decrease in the rate of polymerization probably as a result of the decrease in the reactivity of the flavin triplet state. The effect of pH and viscosity of the medium on the rate of reaction has been evaluated.
authors.affiliation: Institute of Pharmaceutical Sciences, Baqai Medical University, 51 Deh Tor, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, Pakistan.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Ahmad
authors.forename: Kefi
authors.initials: K
authors.lastname: Iqbal
authors.forename: Muhammad Ali
authors.initials: MA
authors.lastname: Sheraz
authors.forename: Sofia
authors.initials: S
authors.lastname: Ahmed
authors.forename: Tania
authors.initials: T
authors.lastname: Mirza
authors.forename: Sadia Hafeez
authors.initials: SH
authors.lastname: Kazi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aminuddin