title: Describing the silent human virome with an emphasis on giant viruses.
abstract: Viruses are the most abundant obligate intracellular entities in our body. Until recently, they were only considered to be pathogens that caused a broad array of pathologies, ranging from mild disease to deaths in the most severe cases. However, recent advances in unbiased mass sequencing techniques as well as increasing epidemiological evidence have indicated that the human body is home to diverse viral species under non-pathological conditions. Despite these studies, the description of the presumably healthy viral flora, i.e. the normal human virome, is still in its infancy regarding viral composition and dynamics. This review summarizes our current knowledge of the human virome under non-pathological conditions.
authors.affiliation: URMITE UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, Marseille, France.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Popgeorgiev
authors.forename: Sarah
authors.initials: S
authors.lastname: Temmam
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Christelle
authors.initials: C
authors.lastname: Desnues
mesh_terms: D001769:Blood / Q000821:virology; D041981:Gastrointestinal Tract / Q000821:virology; D006801:Humans; D064307:Microbiota; D009420:Nervous System / Q000821:virology; D012137:Respiratory System / Q000821:virology; D012867:Skin / Q000821:virology; D014566:Urogenital System / Q000821:virology; D014780:Viruses / Q000145:classification* / Q000302:isolation & purification*