title: Kisspeptin/KISS1R System in Breast Cancer.
abstract: Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that KP/KISS1R pathway plays detrimental roles in breast cancer. In this review, we summarize recent developments in the understanding of the mechanisms regulating KP/KISS1R signaling in breast cancer metastasis.
authors.affiliation: 1. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1;
authors.forename: Donna
authors.initials: D
authors.lastname: Cvetković
authors.forename: Andy V
authors.initials: AV
authors.lastname: Babwah
authors.forename: Moshmi
authors.initials: M
authors.lastname: Bhattacharya
keywords: G protein-coupled receptor.; KISS1R; Kisspeptin; breast cancer; invasion; metastasis