title: Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway.
abstract: In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Huang
authors.forename: Jianming
authors.initials: J
authors.lastname: Han
authors.forename: Wenling
authors.initials: W
authors.lastname: Zheng
authors.forename: Wenli
authors.initials: W
authors.lastname: Ma
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007659:Ketones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D031344:Perilla frutescens / Q000737:chemistry*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007659:Ketones; D010936:Plant Extracts; C568138:isoegomaketone; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt
keywords: HCC; IK; PI3K/AKT; Perilla Frutescens; Tumor Proliferation