title: Neuro-ophthalmologic complications of neoplastic leptomeningeal disease.
abstract: Neoplastic leptomeningeal disease (NLD), which encompasses both primary and secondary leptomeningeal tumors, has a devastating impact on the life of cancer patients. The present diagnostic technical armamentarium is insufficient for early diagnosis of NLD. However, NLD may present with subtle neuro-ophthalmic features at a time of relatively small tumor burden, which gives the provider first encountering these patients the window of opportunity for early diagnosis and consequently improved life expectancy and quality of life of these patients. Therefore, familiarity with early, often subtle neuro-ophthalmic features is an essential tool for diagnosing these patients prior to the development of fixed deficits, which usually portend a dismal prognosis. Future evolving laboratory and neuroimaging technologies are expected to advance our understanding of underlying pathophysiology and early detection of NLD. This paper provides an up-to-date review and synthesis of the current literature with focus on neuro-ophthalmic features and their underlying pathophysiology.
authors.affiliation: Department of Neurology, Neuro-Ophthalmology Unit, Hattiesburg Clinic PA, 415 South 28th Avenue, Hattiesburg, MS, 39401, USA, gszatmary@yahoo.com.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Szatmáry
mesh_terms: D005123:Eye / Q000473:pathology; D005128:Eye Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D059906:Neuroimaging; D011379:Prognosis