title: Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.
abstract: A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.
authors.affiliation: Equipe PNSCM, UMR6226, Université de Rennes 1, 2 avenue du Pr Léon Bernard, 35043 Rennes Cedex, France.
authors.forename: Thi Thanh Huyen
authors.initials: TT
authors.lastname: Trinh
authors.forename: Khanh Hung
authors.initials: KH
authors.lastname: Nguyen
authors.forename: Patricia
authors.initials: P
authors.lastname: de Aguiar Amaral
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gouault
keywords: epimyrtine; gold; gold catalysis; heterocycles; hydroamination; quinolizidine alkaloid; total synthesis