title: [Third-line therapy in a patient with recurrent colon cancer undergoing hemodialysis].
abstract: A 68-year-old man undergoing hemodialysis (HD) was diagnosed with recurrence of colon cancer and liver metastasis. He was treated with oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX4), folinic acid, 5-fluorouracil and irinotecan (FOLFIRI), FOLFIRI+bevacizumab (BV), and cetuximab+irinotecan (CPT-11) as third-line therapy. Each drug was adequately reduced over time, but cetuximab was administered at the standard dose. The patient died of methicillin-resistant Staphylococcus aureus (MRSA) meningitis during the course of cetuximab+CPT-11 therapy, but there was no relation between the meningitis and the therapy. Therefore, each regimen can be safely performed, and cetuximab+CPT-11 therapy showed a significant anti-tumor effect and hence may be an effective regimen.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Seyama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Miyata
authors.forename: Dai
authors.initials: D
authors.lastname: Shida
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maeshiro
authors.forename: Sachio
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Umekita
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D012008:Recurrence; D006435:Renal Dialysis; D016879:Salvage Therapy