title: Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability.
abstract: An on-chip spectral surface plasmon resonance (SPR) biosensor with three parallel channels has been built for biomolecule detections. It is capable of updating intensity baselines to suppress errors induced by light source instability. In order to minimize structure and reduce positional regression uncertainty, the scan operations are achieved by timely changing optical media instead of conventional mechanical scan. The detection results of human immunoglobulin G (hIgG) demonstrated that the baseline updating improves the limitation of detection of hIgG concentration from ~86.1 to ~17.4 ng/mL.
authors.affiliation: Nankai University, Department of Electronics and Microelectronics, Tianjin 300071, ChinabColumbia University, Department of Mechanical Engineering, New York 10027.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Ruping
authors.initials: R
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yujian
authors.initials: Y
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yue
authors.forename: Guohua
authors.initials: G
authors.lastname: Liu
mesh_terms: D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D057230:Limit of Detection; D046208:Microchip Analytical Procedures / Q000379:methods; D008954:Models, Biological; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods
chemical_list: D007074:Immunoglobulin G