title: Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium.
abstract: A new amino acid-sesquiterpene adduct, isoheleproline (1), was isolated from the roots of Inula helenium (elecampane), together with four known sesquiterpene lactones (2-5). The planar configuration of 1 was elucidated on the basis of spectroscopic data analysis, and the relative configuration of 1 was determined by performing a detailed analysis of NOESY correlations and comparing its physicochemical data with the D- and L-proline adducts of 2 obtained by Michael addition. This is the first report of a new amino acid-sesquiterpene adduct from Inula plants.
authors.affiliation: Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Daigo
authors.initials: D
authors.lastname: Wakana
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Demizu
authors.forename: Yukie
authors.initials: Y
authors.lastname: Kumeta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kamakura
authors.forename: Takuro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
mesh_terms: D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C000590636:soheleproline