title: Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between lumican gene -1554 T/C polymorphism and high myopia susceptibility.
  
  
  METHODS
  We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.
  
  
  RESULTS
  Seven case-control studies with a total of 1 233 cases and 936 controls were included. A statistical significant association with high myopia was observed in the recessive model (TT vs CT+CC: OR=1.92; 95%CI=1.14-3.23) and codominant model (TT vs CT: OR=1.81, 95%CI=1.19-2.75).
  
  
  CONCLUSIONS
  The present meta-analysis suggested that lumican -1554 T/C polymorphism might be moderately associated with high myopia susceptibility. This conclusion warrants confirmation by further studies.
authors.affiliation: Department of Ophthalmology, West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China ; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Liao
authors.forename: Xu-Bo
authors.initials: XB
authors.lastname: Yang
authors.forename: Meng
authors.initials: M
authors.lastname: Liao
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Lan
authors.forename: Long-Qian
authors.initials: LQ
authors.lastname: Liu
keywords: gene polymorphism; high myopia; lumican; meta-analysis