title: Validation of the Chinese version of Addenbrooke's cognitive examination-revised for screening mild Alzheimer's disease and mild cognitive impairment.
abstract: OBJECTIVE
  As a suitable test to screen for Alzheimer's disease (AD) or mild cognitive impairment (MCI), studies to validate the Chinese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) are rare.
  
  
  METHODS
  A total of 151 subjects were recruited and the neuropsychological assessments were employed. One-way analysis of variance and Bonferroni correction were used to compare scores of different psychometric scales. Intraclass correlation coefficient (ICC) and Cronbach's coefficient α were used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for mild AD and amnestic subtype of MCI (a-MCI) was assessed by receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  The Chinese ACE-R had good reliability (inter-rater ICC = 0.994; test-retest ICC = 0.967) as well as reliable internal consistency (Cronbach's coefficient α = 0.859). With its cutoff of 67/68, the sensitivity (0.920) and specificity (0.857) were lower than for the Mini-Mental State Examination (MMSE) cutoff (sensitivity 1.000 and specificity 0.937) to screen for mild AD. However, the sensitivity of ACE-R to screen for a-MCI was superior to the MMSE with a cutoff of 85/86. The specificity of ACE-R was lower than that of the MMSE to screen for a-MCI. The area under the ROC curve of ACE-R was much larger than that of the MMSE (0.836 and 0.751) for detecting a-MCI rather than mild AD.
  
  
  CONCLUSIONS
  The Chinese ACE-R is a reliable assessment tool for cognitive impairment. It is more sensitive and accurate in screening for a-MCI rather than for AD compared to the MMSE.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Fang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Jun-Peng
authors.initials: JP
authors.lastname: Zhuang
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Deng
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
authors.forename: Ru-Jing
authors.initials: RJ
authors.lastname: Ren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D044466:Asian People / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000592:standards; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D011594:Psychometrics / Q000592:standards*; D012372:ROC Curve; D015203:Reproducibility of Results; D012720:Severity of Illness Index