title: [Granular cell tumor: report of a complicated vulvar localization of pulmonary metastases].
abstract: Granular cell tumour, or Abrikossoff's tumour, is a rare, ubiquitous tumour, with mostly benign evolution. The malignant forms represent 1-3% of the cases. The vulvar localization is exceptional. We report the case of a 28-year-old patient who presented a vulvar Abrikossoff's tumour. Initially considered benign, the tumour was treated by exclusive local surgery. Five months later, the tumour showed a malignant transformation. The tumour size was 14cm in its major axis with the presence of not systematized scattered mitoses, PS 100 was positive at 100% and Ki 67 to 20%. Because of malignant and economic excision of the neoplasm, the patient received adjuvant radiotherapy. After 20 months, the patient had a local recurrence and lung metastasis, supporting the diagnosis of malignancy. She received two chemotherapy regimens of 5-fluoro-uracil/cisplatin and pacliatxel/carboplatin without any response. Following the failure of chemotherapy, the patient received symptomatic medical treatment. This observation leads to advocate an aggressive surgical treatment and strict supervision of all granular cell tumours.
authors.affiliation: Service de radiothérapie-oncologie, CHU Ibn-Rochd, 85, place Abdelkrim-El-Khattabi, El-Jadida, 24000 Casablanca, Maroc.
authors.forename: N
authors.initials: N
authors.lastname: Tawfiq
authors.forename: S
authors.initials: S
authors.lastname: Sabri
authors.forename: K
authors.initials: K
authors.lastname: Saiss
authors.forename: Z
authors.initials: Z
authors.lastname: Bouchbika
authors.forename: N
authors.initials: N
authors.lastname: Benchekroun
authors.forename: H
authors.initials: H
authors.lastname: Jouhadi
authors.forename: S
authors.initials: S
authors.lastname: Sahraoui
authors.forename: A
authors.initials: A
authors.lastname: Benider
mesh_terms: D000328:Adult; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy
keywords: Forme maligne; Granular cell tumour; Lung metastases; Malignant form; Métastases pulmonaires; Tumeur à cellules granuleuses; Vulva; Vulve