title: Molecular studies and therapeutic targeting of Kaposi's sarcoma herpesvirus (KSHV/HHV-8) oncogenesis.
abstract: Kaposi's sarcoma herpesvirus or human herpesvirus-8 (KSHV/HHV-8) is the etiological agent of Kaposi's sarcoma (KS), an AIDS-defining angioproliferative neoplasm that continues to be a major global health problem and, of primary effusion lymphoma (PEL), a rare incurable B-cell lymphoma. This review describes the research from our laboratory and its collaborators to uncover molecular mechanisms of viral oncogenesis in order to develop new pathogenesis-based therapies to the KSHV-induced AIDS malignancies KS and PEL. They include the discovery of the viral angiogenic oncogene G protein-coupled receptor (vGPCR), the development of mouse models of KSHV and oxidative stress-induced KS, the identification of the role of Rac1-induced ROS in viral oncogenesis of KS and the development of novel therapeutic approaches able to target both latent and lytic oncogenic KSHV infection.
authors.affiliation: Department of Microbiology and Immunology, Graduate Program in Microbiology and Immunology, Miami Center for AIDS Research and Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA, emesri@med.miami.edu.
authors.forename: Enrique A
authors.initials: EA
authors.lastname: Mesri
authors.forename: Lucas E
authors.initials: LE
authors.lastname: Cavallin
authors.forename: Brittany M
authors.initials: BM
authors.lastname: Ashlock
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Leung
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.forename: Pascal J
authors.initials: PJ
authors.lastname: Goldschmidt-Clermont
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D004195:Disease Models, Animal; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D018384:Oxidative Stress; D019899:Paracrine Communication; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000378:metabolism; D057170:Translational Research, Biomedical; D020830:rac1 GTP-Binding Protein / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled; D020830:rac1 GTP-Binding Protein