title: Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues.
abstract: Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.
authors.affiliation: Centro de Investigação em Química da Universidade do Porto, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, P-4169-007 Porto, Portugal.
authors.forename: Bianca C
authors.initials: BC
authors.lastname: Pérez
authors.forename: Iva
authors.initials: I
authors.lastname: Fernandes
authors.forename: Nuno
authors.initials: N
authors.lastname: Mateus
authors.forename: Cátia
authors.initials: C
authors.lastname: Teixeira
authors.forename: Paula
authors.initials: P
authors.lastname: Gomes
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D002934:Cinnamates; D011804:Quinolines; C029010:cinnamic acid; D002738:Chloroquine
keywords: Antimalarials; Antiproliferative; Caco-2; Chloroquine; Cinnamic acid; HFF-1; MCF-7; MKN-28