title: An asymmetric normal-electron-demand aza-Diels-Alder reaction via trienamine catalysis.
abstract: An asymmetric normal-electron-demand aza-Diels-Alder cycloaddition of 2-aryl-3H-indol-3-ones and 2,4-dienals was explored via trienamine catalysis of a chiral secondary amine. Multifunctional tricyclic polyhydropyrido[1,2-a]indoles were efficiently constructed in good stereoselectivity (up to 92% ee, >19 : 1 dr).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. ycchen@scu.edu.cn.
authors.forename: Jing-Xin
authors.initials: JX
authors.lastname: Liu
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Zhou
authors.forename: Jin-Gen
authors.initials: JG
authors.lastname: Deng
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004583:Electrons; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D007211:Indoles; D011108:Polymers; D011725:Pyridines