title: Validity of reduced radiation dose for localized diffuse large B-cell lymphoma showing a good response to chemotherapy.
abstract: To evaluate the validity of a decrease in the radiation dose for patients who were good responders to chemotherapy for localized diffuse large B-cell lymphoma (DLBCL), 91 patients with localized DLBCL who underwent radiotherapy after multi-agent chemotherapy from 1988-2008 were reviewed. Exclusion criteria were as follows: central nervous system or nasal cavity primary site, or Stage II with bulky tumor (≥10 cm). Of these patients, 62 were identified as good responders to chemotherapy. They were divided into two groups receiving either a higher or a lower radiation dose (32-50.4 Gy or 15-30.6 Gy, respectively). There were no statistically significant differences between the lower and higher dose groups in progression-free survival, locoregional progression-free survival or overall survival. Adaptation of decreased radiation dose may be valid for localized DLBCL patients who show a good response to chemotherapy.
authors.affiliation: Department of Radiology, Shinshu University, School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Koiwai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Yoshizawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ina
authors.forename: Ayumu
authors.initials: A
authors.lastname: Fukazawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Sakai
authors.forename: Takesumi
authors.initials: T
authors.lastname: Ozawa
authors.forename: Hirohide
authors.initials: H
authors.lastname: Matsushita
authors.forename: Masumi
authors.initials: M
authors.lastname: Kadoya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D059248:Chemoradiotherapy / Q000401:mortality*; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016393:Lymphoma, B-Cell / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011835:Radiation Protection / Q000706:statistics & numerical data*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
keywords: chemotherapy; diffuse large B-cell lymphoma; radiation dose; radiotherapy