title: Cerebral Sinus and Venous Thrombosis Associated with von Willebrand Factor, Independently of Factor VIII.
abstract: OBJECTIVE
  Previous studies have linked procoagulant factor VIII (F VIII) to an increased risk of venous thrombosis, whereas the relation between plasma von Willebrand factor (VWF) and venous thrombosis remains poorly understood. Elevated VWF levels are frequently found in patients with cerebral sinus and venous thrombosis (CSVT), always in association with high F VIII levels. We describe a patient with CSVT accompanied by elevated VWF levels without high F VIII levels.
  
  
  METHODS
  A 23-year-old healthy man who had headache noticed difficulty in moving the right hand. On the following day, he lost consciousness and had partial seizures of the right hand. After regaining consciousness, weakness of the right extremities developed. The cranial angiogram confirmed occlusion of the superior sagittal sinus. The levels of VWF and F VIII were 238% and 101.9 IU/dl, respectively. We performed balloon percutaneous transluminal angioplasty and mechanical thrombectomy, leading to successful recanalization of the intracranial sinuses. VWF levels were decreased along with radiographic improvement, independently of F VIII.
  
  
  CONCLUSIONS
  VWF may contribute to CSVT and that inhibition of VWF activity potentially has a role in the future treatment of pathological conditions related to venous thrombosis.
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Terashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Hirosei
authors.initials: H
authors.lastname: Horikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Taoka
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Kozue
authors.initials: K
authors.lastname: Saito
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
keywords: cerebral sinus; procoagulant factor VIII; rheolytic thrombectomy; venous infarction; venous thrombosis; von Willebrand factor