title: Thymic regulatory T cell development: role of signalling pathways and transcription factors.
abstract: Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.
authors.affiliation: Centre for Inflammatory Diseases, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, VIC 3168, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Engel
authors.forename: Tom
authors.initials: T
authors.lastname: Sidwell
authors.forename: Ajithkumar
authors.initials: A
authors.lastname: Vasanthakumar
authors.forename: George
authors.initials: G
authors.lastname: Grigoriadis
authors.forename: Ashish
authors.initials: A
authors.lastname: Banerjee
mesh_terms: D018106:CD28 Antigens / Q000378:metabolism; D019175:DNA Methylation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*; D013950:Thymus Gland / Q000276:immunology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D018106:CD28 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D014157:Transcription Factors