title: TSPAN33 is a novel marker of activated and malignant B cells.
abstract: We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
authors.affiliation: Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
authors.forename: Van Phi
authors.initials: VP
authors.lastname: Luu
authors.forename: Peter
authors.initials: P
authors.lastname: Hevezi
authors.forename: Felipe
authors.initials: F
authors.lastname: Vences-Catalan
authors.forename: José Luis
authors.initials: JL
authors.lastname: Maravillas-Montero
authors.forename: Clayton Alexander
authors.initials: CA
authors.lastname: White
authors.forename: Paolo
authors.initials: P
authors.lastname: Casali
authors.forename: Luis
authors.initials: L
authors.lastname: Llorente
authors.forename: Juan
authors.initials: J
authors.lastname: Jakez-Ocampo
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Lima
authors.forename: Natalia
authors.initials: N
authors.lastname: Vilches-Cisneros
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Flores-Gutiérrez
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Santos-Argumedo
authors.forename: Albert
authors.initials: A
authors.lastname: Zlotnik
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002460:Cell Line; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D061251:Primary Cell Culture; D015398:Signal Transduction; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D059470:Tetraspanins / Q000235:genetics / Q000276:immunology*
chemical_list: D015415:Biomarkers; D008070:Lipopolysaccharides; C505521:TSPAN33 protein, human; D059470:Tetraspanins; D013755:Tetradecanoylphorbol Acetate
keywords: B cell maturation antigen; B cells; BCMA; BIGE; BL; Biomarker; Burkitt's lymphoma; DLBCL; Diffuse large B cell lymphoma; HL; Hodgkin's lymphoma; Lupus erythematosus; Lymphoma; NHL; RA; Rheumatoid arthritis; SLE; TSPAN33; Tetraspanin 33; body index of gene expression (database); non-Hodgkin's lymphoma; rheumatoid arthritis; systemic lupus erythematosus; tetraspanin 33