title: Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model.
abstract: Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane potential, and is modulated by second messengers. We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via 's ability to set pyramidal excitability. Our model predicts that in vivo neuromodulatory control of allows flexibly controlling CFC and the timing of gamma discharges at particular theta phases.
authors.affiliation: Department of Physiology & Pharmacology, State University of New York Downstate, Brooklyn, New York, United States of America ; Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Neymotin
authors.forename: Markus M
authors.initials: MM
authors.lastname: Hilscher
authors.forename: Thiago C
authors.initials: TC
authors.lastname: Moulin
authors.forename: Yosef
authors.initials: Y
authors.lastname: Skolnick
authors.forename: Maciej T
authors.initials: MT
authors.lastname: Lazarewicz
authors.forename: William W
authors.initials: WW
authors.lastname: Lytton
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D058256:Brain Waves; D056654:CA3 Region, Hippocampal / Q000502:physiology*; D003198:Computer Simulation; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / Q000378:metabolism; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000187:drug effects / Q000473:pathology; D013826:Theta Rhythm; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid