title: Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer.
abstract: The expression and clinical significance of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and insulin-like growth factor binding protein 7 (IGFBP-7) were investigated in serum and lung cancer tissues from 57 patients with non-small cell lung cancer (NSCLC). Lung cancer tissues at different pathologic stages (27 patients at stages I-II and 30 patients at stages III-IV), normal lung tissues from 17 patients with benign pulmonary disease, and serum samples from both lung cancer and benign pulmonary disease patients were collected during surgery. Enzyme-linked immunosorbent assay and avidin-biotin-peroxidase complex immunohistochemical staining were used to detect IGF-1, IGFBP-3, and IGFBP-7 expression in serum and tissues, respectively. The results show that expression of IGF-1 in lung cancer tissues and serum from NSCLC patients were significantly higher than in the control (P < 0.05). However, expression of IGFBP-3 and IGFBP-7 in cancer tissues and serum from NSCLC patients was significantly lower than in the control (P < 0.05). These results suggest that upregulation of IGF-1 and downregulation of IGFBP-3 and IGFBP-7 may be potential diagnostic biomarkers for NSCLC.
authors.affiliation: Jinan University, Guangzhou, Guangdong, People's Republic of China ; The Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Liang
authors.forename: Jikuan
authors.initials: J
authors.lastname: Liu
authors.forename: Weicheng
authors.initials: W
authors.lastname: Shi
authors.forename: Peiru
authors.initials: P
authors.lastname: Bai
authors.forename: Xialu
authors.initials: X
authors.lastname: Lin
authors.forename: Ruth
authors.initials: R
authors.lastname: Magaye
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
keywords: diagnostic biomarkers; insulin-like growth factor 1; insulin-like growth factor binding protein 3; insulin-like growth factor binding protein 7; non-small cell lung cancer