title: Experimental findings on customized mandibular implants in Göttingen minipigs - a pilot study.
abstract: Reconstructing continuity defects of the mandible is still challenging for surgeons. The currently applied conventional titanium bridging plates have considerable rates of complications. Now, a new technology enables an individual shape-identical creation of a mandibular implant in a form-board design by the method of LaserCUSING using pure titanium. This technology has been successfully performed in previous examinations to individually reconstruct mandibular continuity defects. This pilot study evaluated the surgical procedure in 10 female Göttingen mini pigs. First, a computed tomography scan from a mini pig cranium was performed. A three-dimensional model of the mandible was designed by data conversion. Based on the data, a customized mandibular implant resembling the natural shape was virtually created and manufactured. Then, a continuity defect of the left mandible was created in a standardized way. The implants were inserted into the defect and the wounds were allowed to heal for 21, 35, 56 and 180 days. During the healing period, no signs of inflammation or infection were observed. After the sacrifice of the minipigs the mandibles were resected. Histological microsections using Donath's sawing and grinding technique were manufactured and stained with Masson Goldner trichrome staining. The histomorphological results showed a pronounced ossification at the outer and inner surface of the implants. This animal study describes a promising approach to optimize customized implants for the application in humans.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: jutta.markwardt@uniklinikum-dresden.de.
authors.forename: J
authors.initials: J
authors.lastname: Markwardt
authors.affiliation: Department of Design Engineering/CAD, Technische Universität Dresden, Mommsenstraße 17, 01069 Dresden, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Sembdner
authors.affiliation: Firma Hofmann und Engel, Produktentwicklung GmbH, Kunzer Marktweg 13, 01468 Moritzburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Lesche
authors.affiliation: Experimental Center, Medical Faculty "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Jung
authors.affiliation: Experimental Center, Medical Faculty "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Spekl
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Mai
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
authors.forename: M C
authors.initials: MC
authors.lastname: Schulz
authors.affiliation: Department of Prosthetic Dentistry, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Reitemeier
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D017076:Computer-Aided Design; D005260:Female; D006257:Head / Q000000981:diagnostic imaging; D006651:Histocytochemistry; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D010865:Pilot Projects; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011859:Radiography; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium; D014945:Wound Healing / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D014025:Titanium
keywords: Customized mandibular implant; Göttingen mini pigs; LaserCUSING(®); Mandibular continuity resection; Polychrome sequence labelling