title: Early weight gain predicts outcome in two treatments for adolescent anorexia nervosa.
abstract: OBJECTIVE
  Determine whether early weight gain predicts full remission at end-of-treatment (EOT) and follow-up in two different treatments for adolescent anorexia nervosa (AN), and to track the rate of weight gain throughout treatment and follow-up.
  
  
  METHODS
  Participants were 121 adolescents with AN (mean age = 14.4 years, SD = 1.6), from a two-site (Chicago and Stanford) randomized controlled trial. Adolescents were randomly assigned to family-based treatment (FBT) (n = 61) or individual adolescent focused therapy (AFT) (n = 60). Treatment response was assessed using percent of expected body weight (EBW) and the global score on the Eating Disorder Examination (EDE). Full remission was defined as having achieved ≥95% EBW and within one standard deviation of the community norms of the EDE. Full remission was assessed at EOT as well as 12-month follow-up.
  
  
  RESULTS
  Receiver operating characteristic analyses showed that the earliest predictor of remission at EOT was a gain of 5.8 pounds (2.65 kg) by session 3 in FBT (area under the curve (AUC) = 0.670; p = .043), and a gain of 7.1 pounds (3.20 kg) by session 4 in AFT (AUC = 0.754, p = .014). Early weight gain did not predict remission at follow-up for either treatment. A survival analysis showed that weight was marginally superior in FBT as opposed to AFT (Wald chi-square = 3.692, df = 1, p = .055).
  
  
  CONCLUSIONS
  Adolescents with AN who receive either FBT or AFT, and show early weight gain, are likely to remit at EOT. However, FBT is superior to AFT in terms of weight gain throughout treatment and follow-up.
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois.
authors.forename: Daniel
authors.initials: D
authors.lastname: Le Grange
authors.forename: Erin C
authors.initials: EC
authors.lastname: Accurso
authors.forename: James
authors.initials: J
authors.lastname: Lock
authors.forename: Stewart
authors.initials: S
authors.lastname: Agras
authors.forename: Susan W
authors.initials: SW
authors.lastname: Bryson
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology / Q000628:therapy*; D001835:Body Weight; D005196:Family Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012372:ROC Curve; D012074:Remission Induction; D016896:Treatment Outcome; D015430:Weight Gain
keywords: adolescent anorexia nervosa; adolescent focused therapy; early treatment response; family-based treatment