title: Global determinants of mortality in under 5s: 10 year worldwide longitudinal study.
abstract: OBJECTIVE
  To assess at country level the association of mortality in under 5s with a large set of determinants.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  193 United Nations member countries, 2000-09.
  
  
  METHODS
  Yearly data between 2000 and 2009 based on 12 world development indicators were used in a multivariable general additive mixed model allowing for non-linear relations and lag effects.
  
  
  METHODS
  National rate of deaths in under 5s per 1000 live births
  
  
  RESULTS
  The model retained the variables: gross domestic product per capita; percentage of the population having access to improved water sources, having access to improved sanitation facilities, and living in urban areas; adolescent fertility rate; public health expenditure per capita; prevalence of HIV; perceived level of corruption and of violence; and mean number of years in school for women of reproductive age. Most of these variables exhibited non-linear behaviours and lag effects.
  
  
  CONCLUSIONS
  By providing a unified framework for mortality in under 5s, encompassing both high and low income countries this study showed non-linear behaviours and lag effects of known or suspected determinants of mortality in this age group. Although some of the determinants presented a linear action on log mortality indicating that whatever the context, acting on them would be a pertinent strategy to effectively reduce mortality, others had a threshold based relation potentially mediated by lag effects. These findings could help designing efficient strategies to achieve maximum progress towards millennium development goal 4, which aims to reduce mortality in under 5s by two thirds between 1990 and 2015.
authors.affiliation: Biostatistics, CESP Centre for research in Epidemiology and Population Health, U1018, Inserm; Villejuif, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Hanf
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nacher
authors.forename: Chantal
authors.initials: C
authors.lastname: Guihenneuc
authors.forename: Pascale
authors.initials: P
authors.lastname: Tubert-Bitter
authors.forename: Michel
authors.initials: M
authors.lastname: Chavance
mesh_terms: D000293:Adolescent; D046688:Child Mortality / Q000639:trends; D015362:Child Nutrition Disorders / Q000401:mortality* / Q000517:prevention & control; D002675:Child, Preschool; D003695:Delivery of Health Care / Q000191:economics / Q000592:standards / Q000639:trends; D019049:Developed Countries / Q000706:statistics & numerical data; D003906:Developing Countries / Q000706:statistics & numerical data; D017579:Domestic Violence / Q000706:statistics & numerical data; D004522:Educational Status; D005260:Female; D014943:Global Health / Q000592:standards; D006679:HIV Seropositivity / Q000401:mortality*; D006801:Humans; D007223:Infant; D007226:Infant Mortality / Q000639:trends; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011203:Poverty / Q000191:economics / Q000706:statistics & numerical data / Q000639:trends; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000706:statistics & numerical data; D015995:Prevalence; D011634:Public Health / Q000191:economics / Q000592:standards / Q000639:trends; D012499:Sanitation / Q000592:standards; D014480:United Nations; D014857:Warfare; D014881:Water Supply / Q000592:standards