title: Co-circulation of enteroviruses between apes and humans.
abstract: A total of 139 stool samples from wild chimpanzees, gorillas and bonobos in Cameroon and Democratic Republic of Congo (DRC) were screened for enteroviruses (EVs) by reverse transcription PCR. Enterovirus RNA was detected in 10 % of samples, comprising eight from 58 sampled chimpanzees (13.8 %), one from 40 bonobos (2.5 %) and five from 40 gorillas (12.2 %). Three viruses isolated from chimpanzees grouped with human isolate EV-A89 and four (four chimpanzees, one gorilla) represented a newly identified type, EV-A119. These species A virus types overlapped with those circulating in human populations in the same area. The remaining six strains comprised a new species D type, EV-D120, infecting one chimpanzee and four gorillas, and a single EV variant infecting a bonobo that was remarkably divergent from other EVs and potentially constitutes a new enterovirus species. The study demonstrates both the circulation of genetically divergent EV variants in apes and monkeys as well as those shared with local human populations.
authors.affiliation: Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh, UK.|Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, UK.
authors.forename: Heli
authors.initials: H
authors.lastname: Harvala
authors.affiliation: Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
authors.forename: Dung
authors.initials: D
authors.lastname: Van Nguyen
authors.affiliation: Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
authors.forename: Chloe
authors.initials: C
authors.lastname: McIntyre
authors.affiliation: Institute National de Recherche Biomédicales and Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.|UMI233, Institute de Recherche pour le Développement and University of Montpellier, Montpellier, France.
authors.forename: Steve
authors.initials: S
authors.lastname: Ahuka-Mundeke
authors.affiliation: Projet Prévention du Sida au Cameroun (PRESICA) and Virology Laboratory IMPM/CRMER/IRD, Yaoundé, Cameroon.
authors.forename: Eitel Mpoudi
authors.initials: EM
authors.lastname: Ngole
authors.affiliation: UMI233, Institute de Recherche pour le Développement and University of Montpellier, Montpellier, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Delaporte
authors.affiliation: UMI233, Institute de Recherche pour le Développement and University of Montpellier, Montpellier, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Peeters
authors.affiliation: Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Simmonds
mesh_terms: D000818:Animals; D002163:Cameroon; D016000:Cluster Analysis; D015023:Democratic Republic of the Congo; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000635:transmission / Q000662:veterinary* / Q000821:virology*; D005243:Feces / Q000821:virology; D005838:Genotype; D015186:Hominidae / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D018419:Primate Diseases / Q000635:transmission / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral