title: Prosapogenin A induces apoptosis in human cancer cellsin vitrovia inhibition of the STAT3 signaling pathway and glycolysis.
abstract: Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine,Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF-7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism-related genes. The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA-mediated apoptosis of HeLa, HepG2 and MCF-7 cells.
authors.affiliation: Institute of Traditional Chinese Medicine, College of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China.
authors.forename: Tian-Xiao
authors.initials: TX
authors.lastname: Wang
authors.forename: Zhong-Qing
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Cong
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Shi
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Liu
authors.forename: Fang-Li
authors.initials: FL
authors.lastname: Zhao
keywords: STAT3; apoptosis; glycolysis; prosapogenin A