title: MicroRNAs with a role in gene regulation and in human diseases.
abstract: MicroRNAs (miRNAs) are short 20-22 nucleotide non-coding RNA sequences. Recently identified, these are novel regulators of gene expression at translational level as well as transcriptional level. Alteration in miRNAs level has been observed in a number of human diseases and studies have been conducted on the effect of altered expression level of miRNAs on the development and progression of different diseases. The miRNAs can be used as molecular biomarkers in a number of diseases. Also, miRNAs are promising in providing a new platform for molecular therapeutics of previously incurable diseases. This review will focus on the introduction, recent advances in the field of miRNA and its importance in some human disorders.
authors.affiliation: Atta ur Rehman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan, samibiotech@gmail.com.
authors.forename: Sami
authors.initials: S
authors.lastname: Ullah
authors.forename: Peter
authors.initials: P
authors.lastname: John
authors.forename: Attya
authors.initials: A
authors.lastname: Bhatti
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference
chemical_list: D015415:Biomarkers; D035683:MicroRNAs