title: Induced heat property of polyethyleneglycol-coated iron oxide nanoparticles with dispersion stability for hyperthermia.
abstract: Fe3O4 nanoparticles have been used for hyperthermia treatment in an attempt to overcome various problems. When using hyperthermia treamtment, it is critical to control the surface modification of the particles. Magnetic nanoparticles tend to aggregate due to strong magnetic dipole--dipole attractions. The particles then have a high surface area and are of larger sizes, posing serious practical limitations. The nanoparticles are used to generate maximum heat and to maintain a constant heating temperature using the minimum magnetic nanoparticles dosage. In this study, we investigated the effect of PEG coated onto Fe3O4 nanoparticles. We tested the dispersion stability and repetitive heating property of nanoparticles for different PEG concentrations under an AC magnetic field. The results confirmed that the nanoparticles on a colloidal system maintained the heating properties of repetitve inductive heating as PEG concentration increased with dispersion stability. The nanoparticles with superior dispersion stability will be appropriate for hyperthermia applications in cancer treatments.
authors.affiliation: Department of Bionanotechnology, Hanyang University, Ansan 426-791, Korea.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Jang
authors.forename: Young-In
authors.initials: YI
authors.lastname: Lee
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Eun-Sil
authors.initials: ES
authors.lastname: Park
authors.forename: Shin-Choon
authors.initials: SC
authors.lastname: Kang
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Yoon
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Choa
mesh_terms: D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D011092:Polyethylene Glycols