title: Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes.
abstract: Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for EV68. Of total 28 nasopharyngeal sample-positive patients, EV68 was detected in serum samples among 12 (43%) patients aged between 1 and 4 years. Our results suggest that EV68 can cause viremia by which the virus may exhibit systemic manifestations.
authors.affiliation: Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Tadatsugu
authors.initials: T
authors.lastname: Imamura
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Socorro
authors.initials: S
authors.lastname: Lupisan
authors.forename: Taro
authors.initials: T
authors.lastname: Kamigaki
authors.forename: Michiko
authors.initials: M
authors.lastname: Okamoto
authors.forename: Chandra Nath
authors.initials: CN
authors.lastname: Roy
authors.forename: Remigio
authors.initials: R
authors.lastname: Olveda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Oshitani
mesh_terms: D002675:Child, Preschool; D004769:Enterovirus Infections / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000821:virology; D063868:Patient Outcome Assessment; D011024:Pneumonia, Viral / Q000150:complications* / Q000453:epidemiology / Q000821:virology*; D012189:Retrospective Studies; D044967:Serum / Q000821:virology*; D014766:Viremia / Q000453:epidemiology / Q000821:virology*
keywords: Enterovirus 68; pediatric pneumonia; viremia