title: Effect of gold nanoparticles on photodynamic efficiency of 5-aminolevolenic acid photosensitiser in epidermal carcinoma cell line: an in vitro study.
abstract: In the recent years, enhanced functionality of treatment systems based on nanostructures has attracted a lot of interest. Photodynamic therapy (PDT) is one such treatment method. Here, the authors report the results of the investigations on synthesis and characterisation of gold nanoparticles (GNPs) and their application in PDT along with 5-aminolevolenic acid (5-ALA) (as photosensitiser) with no conjugation. Three sizes of GNPs were synthesised and their cytotoxicity was investigated by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on epidermal carcinoma cell line. The results showed that the PDT efficiency of ALA increased in presence of GNPs. This effect was more considerable for 4 nm particles.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Amini
authors.forename: Sharmin
authors.initials: S
authors.lastname: Kharrazi
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Hadizadeh
authors.forename: Mohsen
authors.initials: M
authors.lastname: Fateh
authors.forename: Reza
authors.initials: R
authors.lastname: Saber
mesh_terms: D000622:Aminolevulinic Acid / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects*; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000378:metabolism*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D017319:Photosensitizing Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D006046:Gold; D000622:Aminolevulinic Acid; C022616:thiazolyl blue