title: Sclerosing stromal tumour in young women: clinicopathologic and immunohistochemical spectrum.
abstract: OBJECTIVE
  Sclerosing stromal tumor is a benign tumor of ovary. We aimed to review the clinical findings and immunohistochemical results of SSTs through the 7 diagnosed cases in our hospital.
  
  
  METHODS
  As immunohistochemical, blocks were applied with estrogen receptor , progesterone receptor, inhibin, calretinin, melan-A, CD10, smooth muscle actin, desmine, vimentin, CD34, S-100, C-kit, cytokeratin , cytokeratin7.
  
  
  RESULTS
  Macroscopically, while 5 tumors had solid appearance, 2 tumors were composed of solid and cystic areas. All the tumors were in shape of ovarian masses with good limits. Microscopically, two types of cells were observed as fusiform fibroblast-like cells and theca-like cells with vacuolised cytoplasm. Immunohistochemical results: vimentin, smooth muscle actin, desmine, progesterone receptor, calretinin, inhibin were positive in all the cases; S-100, cytokeratin, cytokeratin7, estrogen receptor were negative in all the cases; CD-10 was positive in 2 cases; C-kit was positive in 5 cases; melan-A was positive in 4 cases.
  
  
  CONCLUSIONS
  The significance of these tumors is that it is necessary to distinguish the histopathology in the frozen section in order to protect the other adnexa because of the characteristics to be observed at early ages (2(nd) and 3(rd) decades). Our findings support the conclusion that sclerosing stromal tumors are benign-character tumors that stem from over stroma and are hormonally active tumors because of the detected clinical and immunohistochemical results, although no hormonal effect that could be supported with laboratory tests was observed.
authors.affiliation: Pathologhist, Department of Pathology, Zeynep Kamil Hospital , Burhanettin Ustünel Cad. No.10 Uskudar, Isanbul, Turkey .
authors.forename: Ecmel Isik
authors.initials: EI
authors.lastname: Kaygusuz
authors.forename: Suna
authors.initials: S
authors.lastname: Cesur
authors.forename: Handan
authors.initials: H
authors.lastname: Cetiner
authors.forename: Hulya
authors.initials: H
authors.lastname: Yavuz
authors.forename: Nermin
authors.initials: N
authors.lastname: Koc
keywords: Immunohistochemistry; Ovary; Sclerosing