title: Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010.
abstract: Analysis of 27 rotavirus strains from vaccinated and unvaccinated children revealed reassortment events in 3 strains: a gene derived from a vaccine; a gene acquired from a circulating strain; and reassortment between circulating strains. Data suggest that the widespread use of this monovalent rotavirus vaccine may introduce vaccine genes into circulating human rotaviruses or vice versa.
authors.forename: Tatiana Lundgren
authors.initials: TL
authors.lastname: Rose
authors.forename: Marcelle Figueira
authors.initials: MF
authors.lastname: Marques da Silva
authors.forename: Mariela Martinéz
authors.initials: MM
authors.lastname: Goméz
authors.forename: Hugo Reis
authors.initials: HR
authors.lastname: Resque
authors.forename: Maria Yury Travassos
authors.initials: MY
authors.lastname: Ichihara
authors.forename: Eduardo de Mello
authors.initials: Ede M
authors.lastname: Volotão
authors.forename: José Paulo Gagliardi
authors.initials: JP
authors.lastname: Leite
mesh_terms: D001938:Brazil / Q000453:epidemiology; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D016865:Reassortant Viruses; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D022243:Rotavirus Vaccines / Q000009:adverse effects* / Q000276:immunology
chemical_list: D022243:Rotavirus Vaccines
keywords: Brazil; G1P[8] strains; RVA; Rotarix; phylogenetic analysis; reassortment; rotavirus; vaccine; viruses