title: Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania.
abstract: The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.
authors.affiliation: 1] Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia [2].
authors.forename: Marina L
authors.initials: ML
authors.lastname: Butovskaya
authors.forename: Vasiliy A
authors.initials: VA
authors.lastname: Vasilyev
authors.forename: Oleg E
authors.initials: OE
authors.lastname: Lazebny
authors.forename: Evgenija M
authors.initials: EM
authors.lastname: Suchodolskaya
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Shibalev
authors.forename: Alex M
authors.initials: AM
authors.lastname: Kulikov
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Karelin
authors.forename: Valentina N
authors.initials: VN
authors.lastname: Burkova
authors.forename: Audax
authors.initials: A
authors.lastname: Mabulla
authors.forename: Alexey P
authors.initials: AP
authors.lastname: Ryskov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000374:Aggression / Q000502:physiology*; D000786:Anger / Q000502:physiology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005838:Genotype; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D011795:Surveys and Questionnaires; D013636:Tanzania; D018911:Trinucleotide Repeats; D055815:Young Adult
chemical_list: C410798:AR protein, human; C581293:DRD2 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D011944:Receptors, Androgen; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase