title: Major depressive disorder induced by prolactinoma--a case report.
abstract: Prolactinomas, the most common type of pituitary tumor, can induce hyperprolactinemia and cause some psychiatric symptoms, such as anxiety, depression and even psychotic symptoms. However, in previous case reports, no information about estrogen levels was mentioned. Here, we present a 48-year-old female patient who had a recurrent episode of major depressive disorder (MDD) and amenorrhea. Hyperprolactinemia (167 ng/ml), low estrogen (15.31 pg/ml) and a pituitary prolactinoma were found by MRI. After a dopamine agonist (Dostinex) and aripiprazole were prescribed, the patient's depressed mood remitted and her menstruation normalized. The possible mechanism of MDD induced by prolactinoma is discussed.
authors.affiliation: Department of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Liao
authors.affiliation: Department of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan; Department of Psychiatry, Collage of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Electronic address: ymbi@mail2000.com.tw.
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Bai
mesh_terms: D000568:Amenorrhea / Q000188:drug therapy / Q000209:etiology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D000077465:Cabergoline; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000209:etiology*; D018491:Dopamine Agonists / Q000627:therapeutic use; D004873:Ergolines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy; D015175:Prolactinoma / Q000150:complications*; D015363:Quinolones / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D004873:Ergolines; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D000077465:Cabergoline
keywords: Hyperprolactinemia; Major depressive disorder; Pitutary adenoma; Prolactinoma