title: Vitamin D deficiency at pediatric intensive care admission.
abstract: OBJECTIVE
  to assess whether 25hydroxivitaminD or 25(OH)vitD deficiency has a high prevalence at pediatric intensive care unit (PICU) admission, and whether it is associated with increased prediction of mortality risk scores.
  
  
  METHODS
  prospective observational study comparing 25(OH)vitD levels measured in 156 patients during the 12 hours after critical care admission with the 25(OH)vitD levels of 289 healthy children. 25(OH)vitD levels were also compared between PICU patients with pediatric risk of mortality III (PRISM III) or pediatric index of mortality 2 (PIM 2) > p75 [(group A; n = 33) vs. the others (group B; n = 123)]. Vitamin D deficiency was defined as < 20 ng/mL levels.
  
  
  RESULTS
  median (p25-p75) 25(OH)vitD level was 26.0 ng/mL (19.2-35.8) in PICU patients vs. 30.5 ng/mL (23.2-38.6) in healthy children (p = 0.007). The prevalence of 25(OH)vitD < 20 ng/mL was 29.5% (95% CI: 22.0-37.0) vs. 15.6% (95% CI: 12.2-20.0) (p = 0.01). Pediatric intensive care patients presented an odds ratio (OR) for hypovitaminosis D of 2.26 (CI 95%: 1.41-3.61). 25(OH)vitD levels were 25.4 ng/mL (CI 95%: 15.5-36.0) in group A vs. 26.6 ng/mL (CI 95%: 19.3-35.5) in group B (p = 0.800).
  
  
  CONCLUSIONS
  hypovitaminosis D incidence was high in PICU patients. Hypovitaminosis D was not associated with higher prediction of risk mortality scores.
authors.affiliation: Pediatric Intensive Care Unit, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain. Electronic address: crey@uniovi.es.
authors.forename: Corsino
authors.initials: C
authors.lastname: Rey
authors.affiliation: Pediatric Day Care Center of Culleredo and Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sánchez-Arango
authors.affiliation: Pediatric Intensive Care Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Herce
authors.affiliation: Oficina de Investigación Biosanitaria FICYT, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Camblor
authors.affiliation: Pediatric Service, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: García-Hernández
authors.affiliation: Biochemical Department, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Prieto
authors.affiliation: Pediatric Service, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Zamir
authors.initials: Z
authors.lastname: Pallavicini
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology / Q000401:mortality
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25 hydroxivitamin D; 25‐hidroxivitamina D; Crianças gravemente doentes; Critical care; Critically‐ill children; Indicadores prognósticos; Mortality risk; Prognostic markers; Risco de mortalidade; Terapia intensiva