title: Preparation of a hollow porous molecularly imprinted polymer using tetrabromobisphenol A as a dummy template and its application as SPE sorbent for determination of bisphenol A in tap water.
abstract: In this paper, a highly selective sample cleanup procedure combing dummy molecular imprinting and solid-phase extraction (DMIP-SPE) was developed for the isolation and determination of bisphenol A (BPA) in tap water. The novel hollow porous dummy molecularly imprinted polymer (HPDMIP) was prepared adopting a sacrificial support approach, using tetrabromobisphenol A (TBBPA), whose structure was similar to that of BPA, as the dummy template and mesoporous MCM-48 nanospheres as the support. Owing to a very short distance between the binding sites and the surface, a large surface area and a good steric structure to match its imprint molecules, the maximum adsorption capacities (Qmax) of the dummy-imprinted and non-imprinted sorbents for BPA were as high as 445 and 340 μmol g(-1), respectively, and the adsorption reached about 73% of Qmax in 10 min. Meanwhile, a method was developed for the determination of BPA using HPDMIP as a solid-phase extraction enrichment sorbent coupled with HPLC. Under the optimum experimental conditions, HPDMIP exhibited satisfactory results in the enrichment and determination of BPA in tap water with a recovery rate of 95-105%, and relative standard deviations of below 6%, and it can achieve a limit of detection as low as 3 ng mL(-1). The developed extraction protocol eliminated the effect of template leakage on quantitative analysis and could be applied for the determination of BPA in complicated functional samples.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Xuebin
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongwu
authors.initials: H
authors.lastname: Tong
authors.forename: Yeping
authors.initials: Y
authors.lastname: Xu
authors.forename: Shaomin
authors.initials: S
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D001559:Benzhydryl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D060766:Drinking Water / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D010636:Phenols / Q000032:analysis*; D011075:Polybrominated Biphenyls / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D060766:Drinking Water; D008689:Methacrylates; D010636:Phenols; D011075:Polybrominated Biphenyls; D012822:Silicon Dioxide; D014874:Water Pollutants, Chemical; C004919:ethylene dimethacrylate; C020806:tetrabromobisphenol A; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; High-performance liquid chromatography; Hollow porous dummy molecularly imprinted polymer; Solid-phase extraction