title: Compensatory growth of C2C12 myotubes induced by the combined effect of lysine sufficiency and modulation of IGF-I and glucocorticoid levels.
abstract: We have reported that a change from a lysine-deficient diet to a lysine-sufficient diet induced compensatory growth in rats and pigs. The aim of the present study was to determine whether compensatory growth of C2C12 myotubes occurs only by sufficiency of lysine or also by the synergic effect of sufficiency of lysine and modulation of the levels of insulin-like growth factor-I (IGF-I) and glucocorticoid in a medium. The results provide the first evidence of compensatory growth of C2C12 myotubes induced by sufficiency of a single amino acid in combination with modulation of the levels of IGF-I and glucocorticoid.
authors.affiliation: Animal Physiology and Nutrition Research Division, NARO Institute of Livestock and Grassland Science.
authors.forename: Aiko
authors.initials: A
authors.lastname: Ishida
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nakashima
authors.forename: Takahito
authors.initials: T
authors.lastname: Kyoya
authors.forename: Masaya
authors.initials: M
authors.lastname: Katsumata
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003470:Culture Media; D003907:Dexamethasone / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology*; D008239:Lysine / Q000378:metabolism*; D051379:Mice; D032448:Myoblasts, Skeletal / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects
chemical_list: D003470:Culture Media; C519530:insulin-like growth factor-1, mouse; D007334:Insulin-Like Growth Factor I; D003907:Dexamethasone; D008239:Lysine