title: Mitochondria and familial predisposition to breast cancer.
abstract: Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.
authors.affiliation: National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Bari-Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Weigl
authors.forename: Angelo
authors.initials: A
authors.lastname: Paradiso
authors.forename: Stefania
authors.initials: S
authors.lastname: Tommasi
keywords: DNA variations; Hereditary breast cancer; Mitochondrial DNA; Mitochondrial haplogroup.; Polymorphism