title: Effect of urinary bisphenolA on androgenic hormones and insulin resistance in preadolescent girls: a pilot study from the Ewha Birth & Growth Cohort.
abstract: To assess the effect of urinary bisphenol A (BPA) on repeated measurements of androgenic hormones and metabolic indices, we used multivariate analysis of variance (MANOVA) adjusted for potential confounders at baseline. During July to August 2011, 80 preadolescent girls enrolled in the Ewha Birth &amp; Growth Cohort study participated in a follow-up study and then forty-eight of them (60.0%) came back one year later. Baseline levels of estradiol and androstenedione were higher in the BPA group than in the non-BPA group. One year later, girls in the high BPA exposure group showed higher levels of androstenedione, testosterone, estradiol, and insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index, than those in the other groups (p < 0.05). In MANOVA, estradiol and androstenedione showed significant differences among groups, while dehydroepiandrosterone, insulin, and HOMA-IR showed marginally significant differences. Exposure to BPA may affect endocrine metabolism in preadolescents. However, further investigation is required to elucidate the mechanisms linking BPA with regulation of androgenic hormones.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea. hpark@ewha.ac.kr.
authors.forename: Hye Ah
authors.initials: HA
authors.lastname: Lee
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hwayoung
authors.initials: H
authors.lastname: Lee
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Gwak
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Park
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Cho
authors.forename: Hae Soon
authors.initials: HS
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Hyesook
authors.initials: H
authors.lastname: Park
mesh_terms: D000728:Androgens / Q000097:blood*; D000735:Androstenedione / Q000097:blood*; D001559:Benzhydryl Compounds / Q000652:urine*; D015992:Body Mass Index; D002648:Child; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D010636:Phenols / Q000652:urine*; D056910:Republic of Korea; D013739:Testosterone / Q000097:blood*; D000098826:Bisphenol A Compounds
chemical_list: D000728:Androgens; D000735:Androstenedione; D001559:Benzhydryl Compounds; D007328:Insulin; D010636:Phenols; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds