title: Androgen receptor signaling fuels DNA repair and radioresistance in prostate cancer.
abstract: Successful treatment by genotoxic modalities including radiotherapy is commonly hampered by treatment resistance in advanced cancers. Two new studies now reveal that androgen receptor signaling transcriptionally upregulates a large subset of DNA repair genes, thereby enhancing the repair capacity and promoting radioresistance of prostate cancer. These results provide a mechanistic rationale for a combined treatment by ionizing radiation and androgen deprivation therapy.
authors.affiliation: 1Danish Cancer Society Research Center, Copenhagen, Denmark; and 2Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Bartek
authors.forename: Martin
authors.initials: M
authors.lastname: Mistrik
authors.forename: Jirina
authors.initials: J
authors.lastname: Bartkova
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D004260:DNA Repair; D051747:DNA-Activated Protein Kinase / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen; D051747:DNA-Activated Protein Kinase