title: Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia.
abstract: Although cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clear that microenvironment-mediated epigenetic alterations play important roles. Aberrant promoter hypermethylation is a prevalent phenomenon in human cancers as well as malignant lymphoma/leukemia. Tumor suppressor genes become frequent targets of aberrant hypermethylation in the course of gene-silencing due to the increased and deregulated DNA methyltransferases (DNMTs). The purpose of this article is to review the current status of knowledge about the contribution of cumulative epigenetic abnormalities of the host genes after microbial and virus infection to the crisis and progression of malignant lymphoma/leukemia. In addition, the relevance of this knowledge to malignant lymphoma/leukemia assessment, prevention and early detection will be discussed.
authors.affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. oka@md.okayama-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oka
authors.forename: Hiaki
authors.initials: H
authors.lastname: Sato
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ouchida
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino