title: [Advances in the pathogenesis and treatment of neurosurgical emergency with coagulation disorders].
abstract: Neurosurgical emergencies including intracranial hemorrhage and head trauma have high mortality and morbidity rates and meanwhile are often accompanied with coagulation disorders. On one hand, coagulation disorder follows traumatic brain injury;on the other hand, the increasing use of anticoagulant and antiplatelet treatment for cardiovascular diseases increases the risk of death among patients with brain trauma or bleeding. Once the intracranial pressure increases, such patients need emergency surgical intervention, but coagulation disorder is a relative contraindication. This article reviews the pathogenesis and treatment of coagulation disorders in patients with neurosurgical emergency. It also analyzes clinical monitoring indices for such patients and their variations and summarizes the strategies and measures of perioperative management.
authors.affiliation: Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Jia-ni
authors.initials: JN
authors.lastname: Wang
authors.forename: Jun-ji
authors.initials: JJ
authors.lastname: Wei
mesh_terms: D001778:Blood Coagulation Disorders / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D001930:Brain Injuries / Q000150:complications / Q000601:surgery*; D004630:Emergencies; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000601:surgery*