title: Aspirin resistant patients with recent ischemic stroke.
abstract: Some patients with a recent ischemic stroke who are being treated with aspirin as an antiaggregant suffer a new ischemic stroke. These patients (15-25%) have been called unresponsive to aspirin or aspirin resistant. The aspirin-resistant patients have a four-time greater risk of suffering a stroke. Furthermore, these strokes are generally more severe, with increased infarct volume and greater risk of recurrence. There is currently no ideal laboratory test to detect the resistance to the antiaggregant effect of aspirin. The study of resistance to aspirin would only be indicated in selected cases. In these patients, one should first rule out any "pseudo-resistance" to aspirin (lack of compliance, concomitant treatments that interfere with the action of the aspirin).
authors.affiliation: Servicio de Medicina Interna, Hospital de la Merced, Osuna, Sevilla, España. Electronic address: castillafernandez@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Castilla-Guerra
authors.affiliation: Servicio de Medicina Interna, Hospital de la Merced, Osuna, Sevilla, España.
authors.forename: M S
authors.initials: MS
authors.lastname: Navas-Alcántara
authors.affiliation: Servicio de Neurología, Hospital de Valme, Sevilla, España.
authors.forename: M C
authors.initials: MC
authors.lastname: Fernández-Moreno
mesh_terms: D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000517:prevention & control; D004351:Drug Resistance; D005260:Female; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012008:Recurrence; D020521:Stroke / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Aspirin resistance; Ictus isquémico; Ictus recurrente; Ischemic stroke; Prevención secundaria; Recurrent stroke; Resistencia a aspirina; Secondary prevention