title: Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
abstract: Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
authors.affiliation: 1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Department of Pharmacology and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Song
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Sun
authors.forename: Jonathan
authors.initials: J
authors.lastname: Moss
authors.forename: Zhexing
authors.initials: Z
authors.lastname: Wen
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Sun
authors.forename: Derek
authors.initials: D
authors.lastname: Hsu
authors.forename: Chun
authors.initials: C
authors.lastname: Zhong
authors.forename: Heydar
authors.initials: H
authors.lastname: Davoudi
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Christian
authors.forename: Nicolas
authors.initials: N
authors.lastname: Toni
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Ming
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002470:Cell Survival; D000089622:Doublecortin Domain Proteins; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development; D007395:Interneurons / Q000378:metabolism* / Q000648:ultrastructure; D008164:Luminescent Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009415:Nerve Net / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D010671:Phenylurea Compounds; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D014161:Transduction, Genetic
chemical_list: D000089622:Doublecortin Domain Proteins; D008164:Luminescent Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C512641:Palm protein, mouse; D010671:Phenylurea Compounds; D010750:Phosphoproteins; C032766:ethylene diurea