title: Differences in gene expression between clonal variants of Mycobacterium tuberculosis emerging as a result of microevolution.
abstract: Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution in a single host or after sequential infection of different hosts. The significance of subtle genotypic variations is still unknown. In three of the four loci analyzed from clonal variants differing in only one MIRU-VNTR locus, we found that the expression of the adjacent genes was modulated differently. These data highlight the potential advantages that acquisition of subtle variability may have in M. tuberculosis.
authors.affiliation: Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias-CIBERES (CD06/06/0058), Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Pérez-Lago
authors.forename: Yurena
authors.initials: Y
authors.lastname: Navarro
authors.forename: Marta
authors.initials: M
authors.lastname: Herranz
authors.forename: Emilio
authors.initials: E
authors.lastname: Bouza
authors.forename: Darío
authors.initials: D
authors.lastname: García-de-Viedma
mesh_terms: D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D014644:Genetic Variation; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification*; D014376:Tuberculosis
keywords: MIRU-VNTR; Microevolution; Tuberculosis