title: Effect of dietary combination of methionine and fish oil on cellular immunity and plasma fatty acids in infectious bursal disease challenged chickens.
abstract: This study was carried out to investigate the modulatory effects of dietary methionine and fish oil on immune response, plasma fatty acid profile, and blood parameters of infectious bursal disease (IBD) challenged broiler chickens. A total of 300 one-day-old male broiler chicks were assigned to one of six dietary treatment groups in a 3 × 2 factorial arrangement. There were three levels of fish oil (0, 2.5 and 5.5%), and two levels of methionine (NRC recommendation and twice NRC recommendation). The results showed that the birds fed with 5.5% fish oil had higher total protein, white blood cell count, and IL-2 concentration than those of other groups at 7 days after IBD challenge. Inclusion of fish oil in diet had no effect on IFN- γ concentration. However, supplementation of methionine twice the recommendation enhanced the serum IFN- γ and globulin concentration. Neither of fish oil nor methionine supplementation affected the liver enzymes concentration. It can be suggested that a balance of moderate level of fish oil (2.5%) and methionine level (twice NRC recommendation) might enhance immune response in IBD challenged broiler chickens.
authors.affiliation: Department of Animal Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Elham
authors.initials: E
authors.lastname: Maroufyan
authors.forename: Azhar
authors.initials: A
authors.lastname: Kasim
authors.forename: Goh
authors.initials: G
authors.lastname: Yong Meng
authors.forename: Mahdi
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: Loh
authors.initials: L
authors.lastname: Teck Chwen
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Mehrbod
authors.forename: Behnam
authors.initials: B
authors.lastname: Kamalidehghan
authors.forename: Abdoreza
authors.initials: A
authors.lastname: Soleimani Farjam
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000097:blood; D018175:Birnaviridae Infections / Q000178:diet therapy / Q000276:immunology / Q000662:veterinary*; D002645:Chickens; D019587:Dietary Supplements; D005227:Fatty Acids / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005395:Fish Oils / Q000008:administration & dosage*; D007111:Immunity, Cellular; D007243:Infectious bursal disease virus; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D011201:Poultry Diseases / Q000097:blood / Q000178:diet therapy* / Q000276:immunology*; D012712:Serum Globulins / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D007376:Interleukin-2; D012712:Serum Globulins; D007371:Interferon-gamma; D008715:Methionine