title: Management of hepatocellular carcinoma.
abstract: Management of hepatocellular carcinoma (HCC) is a rapidly evolving field. Advances in liver surgery and transplantation mean that curative treatment can be offered to patients with HCC in compensated livers who are diagnosed early or to those who are within transplant criteria. Explanted livers have provided a growing understanding of the underlying mechanisms in hepatocarcinogenesis and diagnostic modalities. Several locoregional therapies are also available. For advanced tumors, molecular targeted therapies are yielding promising results. Because of the heterogeneity of the patients and the disease, many questions are waiting for answers through well-designed, adequately powered, and bias-free multicenter, controlled, randomized trials.
authors.affiliation: Department of Surgery, Methodist J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Texas Medical Center, 6550 Fannin SM 1661, Houston, TX 77030, USA. Electronic address: ehasham@houstonmethodist.org.
authors.forename: Emad H
authors.initials: EH
authors.lastname: Asham
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kaseb
authors.forename: R Mark
authors.initials: RM
authors.lastname: Ghobrial
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000601:surgery / Q000628:therapy*; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D015897:Comorbidity; D018450:Disease Progression; D018274:Electroporation; D058625:End Stage Liver Disease / Q000601:surgery; D005234:Fatty Liver / Q000453:epidemiology; D015316:Genetic Therapy; D006518:Hepatitis Viruses / Q000502:physiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D014779:Virus Replication
keywords: Hepatocellular carcinoma (HCC); Liver resection; Liver transplant; Locoregional therapy; Systemic therapy