title: Synthesis and in vitro analysis of novel dihydroxyacetophenone derivatives with antimicrobial and antitumor activities.
abstract: Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Zbancioc
authors.forename: Anca
authors.initials: A
authors.lastname: Miron
authors.forename: Cristina
authors.initials: C
authors.lastname: Tuchilus
authors.forename: Pincu
authors.initials: P
authors.lastname: Rotinberg
authors.forename: Cosmin Teodor
authors.initials: CT
authors.lastname: Mihai
authors.forename: Ionel I
authors.initials: II
authors.lastname: Mangalagiu
authors.affiliation: "Al. I. Cuza" University of Iasi, Department of Organic and Biochemistry, 11 Carol I, Iasi-700506, Romania. zbanciocg@chem.uaic.ro.
authors.forename: Gheorghita
authors.initials: G
authors.lastname: Zbancioc
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000098:Acetophenones; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; C019339:2,6-dihydroxyacetophenone