title: In-line phase contrast micro-CT reconstruction for biomedical specimens.
abstract: X-ray phase contrast micro computed tomography (micro-CT) can non-destructively provide the internal structure information of soft tissues and low atomic number materials. It has become an invaluable analysis tool for biomedical specimens. Here an in-line phase contrast micro-CT reconstruction technique is reported, which consists of a projection extraction method and the conventional filter back-projection (FBP) reconstruction algorithm. The projection extraction is implemented by applying the Fourier transform to the forward projections of in-line phase contrast micro-CT. This work comprises a numerical study of the method and its experimental verification using a biomedical specimen dataset measured at an X-ray tube source micro-CT setup. The numerical and experimental results demonstrate that the presented technique can improve the imaging contrast of biomedical specimens. It will be of interest for a wide range of in-line phase contrast micro-CT applications in medicine and biology.
authors.affiliation: Research Center of Digital Radiation Imaging and Biomedical Imaging, Beijing University of Aeronautics and Astronautics, 100191 Beiijng, People's Republic of China. E-mail: fujian706@buaa.edu.cn, tanrb706@me.buaa.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Fu
authors.forename: Renbo
authors.initials: R
authors.lastname: Tan
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D054893:Cone-Beam Computed Tomography / Q000379:methods; D005583:Fourier Analysis; D007313:Insecta; D008962:Models, Theoretical; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D012031:Refractometry; D012984:Software; D055114:X-Ray Microtomography / Q000379:methods*; D014965:X-Rays
keywords: X-ray in-line phase contrast imaging; X-ray tube source; micro computed tomography; reconstruction algorithm