title: Synthesis and anti-TMV activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates.
abstract: Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
authors.affiliation: Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China. hanx@gzmu.edu.cn.
authors.forename: Han
authors.initials: H
authors.lastname: Xiao
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Zheng
authors.forename: Chenghao
authors.initials: C
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Zhining
authors.initials: Z
authors.lastname: Li
authors.forename: Meichuan
authors.initials: M
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology; D008314:Malonates / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans; D052160:Benzothiazoles; D008314:Malonates; C005465:benzothiazole; C105430:benzofuran