title: Developmental origins of nonalcoholic fatty liver disease.
abstract: Obese pregnant women may transmit their metabolic phenotype to offspring, leading to a cycle of obesity and diabetes over generations. Early childhood obesity predicts nonalcoholic fatty liver disease (NAFLD), the most common chronic human liver disease. The fetus may be vulnerable to steatosis because immature fetal adipose depots are not available to buffer the excess transplacental lipid delivery in maternal obesity. In animal models, in utero high-fat diet exposure results in an increase in the accumulation of liver triglycerides in offspring and increased hepatic oxidative stress and apoptosis, perhaps priming the liver for later development of NAFLD. Innate immune dysfunction and necroinflammatory changes have been observed in postnatal offspring liver of animals born to high-fat-fed dams. Postweaning, livers of offspring exposed to maternal high-fat feeding in utero share pathophysiologic features with human NAFLD, including increased de novo lipogenesis and decreased free fatty acid oxidation. Human studies using magnetic resonance imaging have shown that maternal BMI predicts infant intrahepatocellular lipid storage, as seen in animal models. The generational transfer of NAFLD may occur via epigenetic changes in offspring liver. Transmission of microbiota from mother to infant may impact energy retention and immune function that contribute to a predisposition to NAFLD.
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: David E
authors.initials: DE
authors.lastname: Brumbaugh
authors.affiliation: 1] Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado [2] Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Friedman
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007422:Intestines / Q000382:microbiology; D008099:Liver / Q000196:embryology / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D039382:Maternal Nutritional Physiological Phenomena; D064307:Microbiota; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors