title: Measurement properties of radial and tibial speed of sound for screening bone fragility in 10- to 12-year-old boys and girls.
abstract: The objective of this study was to analyze measurement properties of the radial and tibial speed of sound (SoS) evaluated by quantitative ultrasound (QUS) for screening bone fragility. Bone fragility was defined as low whole body less head bone mineral density (WBLH BMD) measured by DXA (first tertile, 95% CI -1.1 to -0.9) and as past fractures evaluated by questionnaire. The sample included 319 nonobese boys and girls, ages 10-12 yr. All bone variables were standardized. The results revealed concordance coefficient correlations between WBLH BMD and radial and tibial SoS of 0.129 and 0.038, respectively. The regression lines between DXA and QUS variables were different from the identity lines. Cross-classification analysis by Kappa statistic showed that only 34% and 36% of the 113 participants categorized in the first tertile of WBLH BMD were also categorized in the first tertile of tibial and radial SoS, correspondingly. Logistic regression with gender and maturity adjustments demonstrates that radial SoS was the single significant variable in predicting OR for identifying participants with past fractures. In conclusion, the radial QUS revealed itself to be a valuable tool for screening bone fragility in youth of 10-12 yr, despite the absence of agreement with DXA WBLH BMD.
authors.affiliation: Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
authors.forename: Lurdes M
authors.initials: LM
authors.lastname: Rebocho
authors.affiliation: Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
authors.forename: Graça
authors.initials: G
authors.lastname: Cardadeiro
authors.affiliation: Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
authors.forename: Vera
authors.initials: V
authors.lastname: Zymbal
authors.affiliation: Growth and Body Composition Laboratory, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Ezequiel M
authors.initials: EM
authors.lastname: Gonçalves
authors.affiliation: Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
authors.forename: Luís B
authors.initials: LB
authors.lastname: Sardinha
authors.affiliation: Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal. Electronic address: fbaptista@fmh.utl.pt.
authors.forename: Fátima
authors.initials: F
authors.lastname: Baptista
mesh_terms: D015502:Absorptiometry, Photon; D061725:Accelerometry; D001823:Body Composition; D049628:Body Size; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011884:Radius / Q000000981:diagnostic imaging*; D013977:Tibia / Q000000981:diagnostic imaging*; D014463:Ultrasonography
keywords: Bone density; DXA; QUS; speed of sound; youth