title: [Study on rational daily administration frequency of Fufang Biejia Ruangan tablet based on integrated serum pharmacologic and pharmacokinetic model].
abstract: To observe in vitro the effect of rat drug serum on the proliferation of HSC-T6 hepatic stellate cells in the pharmacokinetic model for determining peoniflorin in Fufang Biejia Ruangan tablet, in order to discover the rational daily administration frequency of Fufang Biejia Ruangan tablet. Fufang Biejia Ruangan tablet was orally administered to rats with different daily administration frequency. Their blood was collected from veins behind eye sockets at different time points before the administration and after the first administration, in order to determine the concentration of peoniflorin in blood plasma and the effect of rat drug serums on the proliferation of HSC-T6. A comprehensive analysis was made on the relationship between pharmacodynamics and pharmacokinetics to determine the rational daily administration frequency of Fufang Biejia Ruangan tablet. The results showed a good correlation between the inhibitory effect of Fufang Biejia Ruangan tablet-contained serum on HSC-T6 and the concentration of peoniflorin in blood. The two-time administration group showed higher pharmacologic and pharmacokinetic AUCs than one-time administration and three-time administration groups. In conclusion, Fufang Biejia Ruangan table is recommended to be taken twice a day for treating liver fibrosis in chronic hepatitis.
authors.affiliation: The 302 Military Hospital of China, Beijing 100039, China. jxbaitree@163.com
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Bai
authors.forename: Ling
authors.initials: L
authors.lastname: Dai
authors.forename: Hong-Ge
authors.initials: HG
authors.lastname: Chen
authors.forename: He
authors.initials: H
authors.lastname: Xu
authors.forename: Rong-Li
authors.initials: RL
authors.lastname: Yin
authors.forename: Jin
authors.initials: J
authors.lastname: Han
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yuan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001565:Benzoates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D001952:Bridged-Ring Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005960:Glucosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D055166:Hepatic Stellate Cells / Q000187:drug effects* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D039821:Monoterpenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D013607:Tablets / Q000008:administration & dosage / Q000493:pharmacokinetics; D006027:Glycosides
chemical_list: D001565:Benzoates; D001952:Bridged-Ring Compounds; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; D013607:Tablets; C015423:peoniflorin; D006027:Glycosides