title: Inflammaging: should this term be suitable for age related macular degeneration too?
abstract: BACKGROUND
  Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than 60 years in developed countries.
  
  
  CONCLUSIONS
  Remarkable correlations have been documented between common or rare immunological/inflammatory gene polymorphisms and AMD, unequivocally indicating the involvement of inflammation and immune-mediated processes (complement activation) in the pathogenesis of this disease.
  
  
  CONCLUSIONS
  Altogether these factors also drive this pathologic condition under the general heading of "Inflammaging".
authors.affiliation: Section Ophthalmology, Department of Medical-Surgical Communication and Behaviour, University of Ferrara, Ferrara, Italy.
authors.forename: Carla Enrica
authors.initials: CE
authors.lastname: Gallenga
authors.forename: Francesco
authors.initials: F
authors.lastname: Parmeggiani
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sebastiani
authors.forename: Pier Enrico
authors.initials: PE
authors.lastname: Gallenga
mesh_terms: D000375:Aging / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008268:Macular Degeneration / Q000276:immunology*