title: Off-axis dose equivalent due to secondary neutrons  from uniform scanning proton beams during proton  radiotherapy.
abstract: The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy−1 for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy−1 for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body.
authors.forename: M R
authors.initials: MR
authors.lastname: Islam
authors.forename: T L
authors.initials: TL
authors.lastname: Collums
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: J
authors.initials: J
authors.lastname: Monson
authors.forename: E R
authors.initials: ER
authors.lastname: Benton
mesh_terms: D009010:Monte Carlo Method; D009502:Neutrons; D061766:Proton Therapy / Q000009:adverse effects*; D011829:Radiation Dosage; D011879:Radiotherapy Dosage