title: Baseline glycated hemoglobin levels are associated with duodenal-jejunal bypass liner-induced weight loss in obese patients.
abstract: BACKGROUND
  Endoscopic treatment with the duodenal-jejunal bypass liner (DJBL) leads to significant weight loss in obese patients. We sought to identify clinical factors associated with weight loss in obese patients treated with the DJBL for 1 year.
  
  
  METHODS
  Subjects with morbid obesity were enrolled in a single-arm, open-label, prospective trial and implanted with the DJBL. Patient demographics along with baseline comorbidities, anthropometrics, and biochemical variables were selected for univariate and multivariate analysis.
  
  
  RESULTS
  The DJBL was implanted in 79 subjects and 61 completed 12 months of follow-up. There were 18 early removals. Baseline mean age and body mass index (BMI) were 35.4 ± 9.7 years and 43 ± 5.6 kg/m(2), respectively. Forty-four (72 %) were women. This population included 22 subjects with type 2 diabetes (T2DM). Twelve months after treatment, patients had a mean excess body weight loss (%EBWL) of 46 ± 18 %. Univariate analysis identified that fasting glycemia (r (2) = -0.303, p < 0.013), insulin-resistance determined by HOMA-IR (r (2) = -0.457, p < 0.019), and glycated hemoglobin (HbA1c) (r (2) = -0.471, p < 0.013) were associated inversely with %EBWL at 1 year. In this cohort of patients, the multivariate analysis indicated that only baseline HbA1c levels were associated inversely with %EBWL after 1 year of treatment (β adjusted coefficient -0.758, p < 0.016). Importantly, no differences at 1 year in %EBWL were observed between patients with or without T2DM (%EBWL T2D 46.7 ± 20 % vs. non-T2DM 46.8 ± 18.6 %, p = 0.988).
  
  
  CONCLUSIONS
  This analysis indicates that higher baseline HbA1c levels are associated independently with diminished body weight loss in obese patients treated with the DJBL independent of their diabetic status. These results show that DJBL induces clinically significant weight loss in both T2DM and non-T2DM patients.
authors.affiliation: Department of Digestive Surgery, School of Medicine, Pontificia Universidad Católica, Santiago, Chile, rmunozc@med.puc.cl.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Muñoz
authors.forename: Angelica
authors.initials: A
authors.lastname: Dominguez
authors.forename: Fernando
authors.initials: F
authors.lastname: Muñoz
authors.forename: Cesar
authors.initials: C
authors.lastname: Muñoz
authors.forename: Milenko
authors.initials: M
authors.lastname: Slako
authors.forename: Dannae
authors.initials: D
authors.lastname: Turiel
authors.forename: Fernando
authors.initials: F
authors.lastname: Pimentel
authors.forename: Alan
authors.initials: A
authors.lastname: Sharp
authors.forename: Alex
authors.initials: A
authors.lastname: Escalona
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D050110:Bariatric Surgery / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004386:Duodenum / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011446:Prospective Studies; D019736:Prostheses and Implants; D011474:Prosthesis Design; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin