title: The impacts of first line highly active antiretroviral therapy on serum selenium, CD4 count and body mass index: a cross sectional and short prospective study.
abstract: BACKGROUND
  The relationship that exists between body weights, serum selenium and immunological markers of HIV/AIDS continue to provoke more researches in the recent times. The objectives of this study were to examine baseline body mass index, CD4 count and serum selenium and to prospectively assess the impacts of HAART on same parameters 48 weeks post HAART among HIV patients.
  
  
  METHODS
  A cohort comprising 140 newly diagnosed HIV positive were prospectively studied. Anthropometric measurements, serum selenium and CD4 count were assessed at diagnosis and 48 weeks post HAART.
  
  
  RESULTS
  The mean age for patients was 35±8.8 years; 68% was female. Patients' mean weight was 56.79±10.22kg, BMI; 21.59±3.53, serum selenium; 0.55 ± 0.45µmol/L and CD4 count; 288.36 ± 232.23 at the baseline. At diagnosis, 47 (33.6%) were in stage 1, 49 (35.0%) in stage 2, 26 (18.6%) and 18 (12.9%) were in stage 3 and 4 respectively. Similarly, most patients had normal body mass index, 94 (67.14%), 26 (18.57%) were underweight, (12.86%) were overweight and two (1.43%) were obese at diagnosis. At 48 weeks post HAART, the mean weight, BMI, serum selenium and CD4 count were significantly increased.
  
  
  CONCLUSIONS
  HAART repleted CD4 count and serum selenium, Post HAART overweight was associated with lesser CD4 count reconstitution and selenium repletion. A renew call for weight monitoring in HAART era.
authors.affiliation: Department of Internal Medicine, Ladoke Akintola University of Technology and LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
authors.forename: Adeolu Oladayo
authors.initials: AO
authors.lastname: Akinboro
authors.forename: Olaniyi
authors.initials: O
authors.lastname: Onayemi
authors.forename: Olugbenga Edward
authors.initials: OE
authors.lastname: Ayodele
authors.forename: Ayodele David
authors.initials: AD
authors.lastname: Mejiuni
authors.forename: Adeniran Samuel
authors.initials: AS
authors.lastname: Atiba
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D011446:Prospective Studies; D012643:Selenium / Q000097:blood*
chemical_list: D012643:Selenium
keywords: BMI; CD4 count; HAART; HIV/AIDS; Selenium