title: Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34.
abstract: As a result of the continued screening for new metabolites produced by endophytic fungi from Thai medicinal plants, two new triene fatty acid amides, bipolamides A (1) and B (2), were discovered from the endophytic fungus Bipolaris sp. MU34. The structures of all of the isolated compounds were elucidated on the basis of the spectroscopic data of NMR and MS. An antimicrobial assay revealed that bipolamide B (2) had moderate antifungal activity against Cladosporium cladosporioides FERMS-9, Cladosporium cucumerinum NBRC 6370, Saccharomyces cerevisiae ATCC 9804, Aspergillus niger ATCC 6275 and Rhisopus oryzae ATCC 10404, with Minimum inhibitory concentration (MIC) values of 16, 32, 32, 64 and 64 μg ml(-1), respectively.
authors.affiliation: International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.
authors.forename: Ratklao
authors.initials: R
authors.lastname: Siriwach
authors.affiliation: International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.affiliation: International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kitani
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Kanokthip
authors.initials: K
authors.lastname: Pansuksan
authors.affiliation: Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Watanalai
authors.initials: W
authors.lastname: Panbangred
authors.affiliation: 1] International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan [2] MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nihira
mesh_terms: D000577:Amides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000201:enzymology*; D001234:Aspergillus niger / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D055808:Drug Discovery; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D012233:Rhizopus / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000577:Amides; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; C587976:bipolamide A; C587975:bipolamide B