title: Inactivated autograft-prosthesis composite has a role for grade III giant cell tumor of bone around the knee.
abstract: BACKGROUND
  Giant cell tumors (GCT) around the knee are common and pose a special problem of reconstruction after tumor excision, especially for grade III GCT. We questioned whether en bloc resection and reconstruction with alcohol inactivated autograft-prosthesis composite would provide (1) local control and long-term survival and (2) useful limb function in patients who had grade III GCT around the knee.
  
  
  METHODS
  We retrospectively reviewed eight patients (5 males and 3 females) treated with this procedure with mean age of 31 years (range 20 to 43 years) from Jan 2007 to Oct 2008. 5 lesions were located in distal femur and 3 in proximal tibia. 4 patients were with primary tumor and the other 4 with recurrence. 2 patients showed pathological fracture.
  
  
  RESULTS
  Mean Follow-up is 54 months ranging from 38 to 47 months. No recurrence, metastasis, prosthesis loosening were found. The mean healing time between autograft and host bone was 5.5 months. The mean MSTS score was 26.3 (88%) ranging from 25 to 29. The mean ISOLS composite graft score was 32.8 (88.5%) ranging from 28 to 35. Creeping substitution is possibly the main way in bony junction. The healing time in femoral lesion is faster than that in tibial lesion.
  
  
  CONCLUSIONS
  The technique of alcohol inactivated autograft-prosthesis composite could be able to achieve satisfactory oncological and functional outcomes in Grade III GCT.
authors.affiliation: Department of Orthopaedics, General Hospital of Ji'Nan Military Region, Ji'Nan 250031, China. yxch48@vip.sina.com.
authors.forename: SongFeng
authors.initials: S
authors.lastname: Xu
authors.forename: XiuChun
authors.initials: X
authors.lastname: Yu
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: ZhiHou
authors.initials: Z
authors.lastname: Fu
mesh_terms: D000328:Adult; D064592:Autografts / Q000637:transplantation*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000601:surgery; D005500:Follow-Up Studies; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D007720:Knee Prosthesis / Q000706:statistics & numerical data*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery; D011859:Radiography; D012189:Retrospective Studies; D013977:Tibia / Q000000981:diagnostic imaging / Q000601:surgery; D055815:Young Adult