title: Enhancement of intestinal IgA production by Ajoene in mice.
abstract: We investigated the effects of ajoene on intestinal IgA production. Ajoene (1.35, 4.5, and 13.5 µg/kg/d) was administered to mice for 4 weeks. The fecal IgA level in the 13.5 µg/kg/d group increased after 3 weeks. The intestinal IgA level also increased in a dose-dependent manner upon ajoene administration. An oil-macerated garlic extract, with 1500 µg/g of ajoene, enhanced the intestinal IgA production.
authors.affiliation: Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Washiya
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Tsuchiyoshi
authors.initials: T
authors.lastname: Fujino
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004220:Disulfides / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D005737:Garlic / Q000737:chemistry*; D018928:Immunity, Mucosal / Q000187:drug effects; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000276:immunology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000069463:Olive Oil; D010936:Plant Extracts / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry; D013454:Sulfoxides
chemical_list: D004220:Disulfides; D007070:Immunoglobulin A; D000069463:Olive Oil; D010936:Plant Extracts; D010938:Plant Oils; D013454:Sulfoxides; C048980:ajoene