title: Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients.
abstract: BACKGROUND
  Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and HO1 as tumor-progressing factors. However, the correlative role of NGF and HO1 and their prognostic impact in breast carcinoma is unknown.
  
  
  METHODS
  We investigated the expression and prognostic significance of the expression of NGF and HO1 in 145 cases of breast carcinoma.
  
  
  RESULTS
  Immunohistochemical expression of NGF and HO1 was observed in 31% and 49% of breast carcinoma, respectively. The expression of NGF and HO1 significantly associated with each other, and both have a significant association with histologic grade, HER2 expression, and latent distant metastasis. The expression of NGF and HO1 predicted shorter overall survival of breast carcinoma by univariate and multivariate analysis. NGF expression was an independent prognostic indicator for relapse-free survival by multivariate analysis. The combined expression pattern of NGF and HO1 was also an independent prognostic indicator of overall survival and relapse-free survival. The patients with tumors expressing NGF had the shortest survival and the patients with tumor, which did not express NGF or HO1 showed the longest survival time.
  
  
  CONCLUSIONS
  This study has demonstrated that individual expression of NGF or HO1, and the combined NGF/HO1 expression pattern could be prognostic indicators for breast carcinoma patients.
authors.forename: Sang Jae
authors.initials: SJ
authors.lastname: Noh
authors.forename: Jun Sang
authors.initials: JS
authors.lastname: Bae
authors.forename: Urangoo
authors.initials: U
authors.lastname: Jamiyandorj
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Park
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Kwon
authors.forename: Sung Hoo
authors.initials: SH
authors.lastname: Jung
authors.forename: Hyun Jo
authors.initials: HJ
authors.lastname: Youn
authors.forename: Ho
authors.initials: H
authors.lastname: Lee
authors.forename: Byung-Hyun
authors.initials: BH
authors.lastname: Park
authors.forename: Myoung Ja
authors.initials: MJ
authors.lastname: Chung
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Moon
authors.forename: Myoung Jae
authors.initials: MJ
authors.lastname: Kang
authors.affiliation: Departments of Pathology, Research Institute of Clinical Medicine and Research Institute for Endocrine Sciences, Chonbuk National University Medical School, Jeonju, Republic of Korea. kyjang@chonbuk.ac.kr.
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D015870:Gene Expression; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D055815:Young Adult
chemical_list: D020932:Nerve Growth Factor; D051547:Heme Oxygenase-1