title: Pharmacological inhibition of actin assembly to target tumor cell motility.
abstract: Tumor metastasis remains an unsolved clinical problem. An initial and essential step in this process is active migration of tumor cells, which critically depends on reorganization of the actin cytoskeleton. Factors regulating actin assembly are just beginning to emerge as potential targets for preventing dissemination and invasion of tumor cells. Recent studies have shown that actin-dependent cellular processes, including tumor invasion, can be pharmacologically modulated by small-molecule inhibitors of actin assembly. In this chapter, we summarize reports on newly identified small-molecule inhibitors that target a growing number of actin nucleation and assembly factors relevant for human disease.
authors.affiliation: Institute of Pharmacology, University of Marburg, Marburg, 35032, Germany, mail@nuernberg.su.
authors.forename: Alexander
authors.initials: A
authors.lastname: Nürnberg
authors.forename: Alina
authors.initials: A
authors.lastname: Kollmannsperger
authors.forename: Robert
authors.initials: R
authors.lastname: Grosse
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000199:Actins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002465:Cell Movement / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000199:Actins; D000970:Antineoplastic Agents