title: Histone variants and sensing of chromatin functional states.
abstract: An extreme case of chromatin remodelling is the genome-wide exchange of histones with basic non-histone DNA-packaging proteins that occurs in post-meiotic male germ cells. The scale of this genome reorganization is such that chromatin needs to undergo a prior "preparation" for a facilitated action of the factors involved. Stage-specific incorporation of specialized histone variants, affecting large domains of chromatin, combined with histone post-translational modifications accompany the successive steps of the male genome reorganization. Recently, it has been shown that a testis-specific H2B variant, TH2B, one of the first identified core histone variants, replaces H2B at the time of cells' commitment into meiotic divisions and contributes to the process of global histone removal. These investigations also revealed a previously unknown histone dosage compensation mechanism that also ensures a functional interconnection between histone variant expression and histone post-translational modifications and will be further discussed here.
authors.affiliation: CEA, iRTSV; Biologie à Grande Echelle; Grenoble, France; INSERM, U1038; Grenoble, France; Université Grenoble-Alpes; Grenoble, France; INSERM, U823; Institut Albert Bonniot; Grenoble, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Govin
authors.affiliation: Université Grenoble-Alpes; Grenoble, France; INSERM, U823; Institut Albert Bonniot; Grenoble, France.
authors.forename: Saadi
authors.initials: S
authors.lastname: Khochbin
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D005260:Female; D006657:Histones / Q000378:metabolism*; D008297:Male; D011479:Protamines / Q000378:metabolism*
chemical_list: D002843:Chromatin; D006657:Histones; D011479:Protamines
keywords: acetylation; arginine methylation; crotonylation; histone chaperone; histone degradation