title: Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H.
abstract: It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: stelar@sund.ku.dk.
authors.forename: Steen
authors.initials: S
authors.lastname: Larsen
authors.affiliation: Department of Biochemistry, Molecular and Cell Biology, University of Zaragoza, Zaragoza, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Díez-Sánchez
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Rasmus
authors.initials: R
authors.lastname: Rabøl
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Ara
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Dela
authors.affiliation: Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jørn W
authors.initials: JW
authors.lastname: Helge
mesh_terms: D002950:Citrate (si)-Synthase / Q000378:metabolism; D005843:Geography; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010539:Permeability
chemical_list: D002950:Citrate (si)-Synthase
keywords: Caucasian mitochondrial haplogroup; Intrinsic mitochondrial function; Mitochondrial OXPHOS capacity