title: Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution.
abstract: Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 Å is reported. The CT584 structure is a hexamer comprised of a trimer of dimers. The structure shares a high degree of similarity to the recently reported structure of an orthologous protein, Cpn0803, from Chlamydia pneumoniae, which highlights the highly conserved nature of this protein across these chlamydial species, despite different tissue tropism and disease pathology.
authors.affiliation: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Barta
authors.forename: John
authors.initials: J
authors.lastname: Hickey
authors.forename: Kyle E
authors.initials: KE
authors.lastname: Kemege
authors.forename: Scott
authors.initials: S
authors.lastname: Lovell
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Battaile
authors.forename: P Scott
authors.initials: PS
authors.lastname: Hefty
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D002692:Chlamydia trachomatis / Q000378:metabolism*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D055503:Protein Multimerization
chemical_list: D001426:Bacterial Proteins
keywords: CT584; Chlamydia trachomatis; type III secretion system