title: NF-kappaB in lung tumorigenesis.
abstract: The development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis. Our current knowledge about the role of the NF-kappaB signaling pathway in the development of lung cancer has been bolstered by animal models demonstrating the connection between K-ras and tobacco induced lung transformation with NF-kappaB. Activation of downstream genes leads to cell proliferation, inhibition of apoptosis, angiogenesis, inflammation, invasion, and metastasis.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, 462 First Avenue, NBV 7N24, New York, NY 10016, USA. william.rom@nyumc.org.
authors.forename: Zhenjian
authors.initials: Z
authors.lastname: Cai
authors.forename: Kam-Meng
authors.initials: KM
authors.lastname: Tchou-Wong
authors.forename: William N
authors.initials: WN
authors.lastname: Rom