title: Adenocarcinoma of the ileocolic junction and multifocal hepatic sarcomas in an aged rhesus macaque (Macaca mulatta).
abstract: An aged male rhesus macaque in our colony had decreased appetite and a loss of interest in behavioral testing. CBC analysis revealed a regenerative, microcytic, hypochromic anemia with thrombocytosis, consistent with iron deficiency. A fecal occult blood test was positive. Ultrasound imaging revealed numerous, vascularized focal liver lesions that suggested metastases. The macaque's appetite continued to decrease, and he became more lethargic. At this point, the investigator elected to euthanize the macaque. At necropsy, the ileocolic junction was white and abnormally thickened, and the liver was pale tan with approximately 18 discrete white masses randomly scattered throughout the hepatic parenchyma. Histologically, the mass at the ileocolic junction was identified as an intestinal adenocarcinoma, whereas the liver masses were confirmed to be undifferentiated hepatic sarcomas. This case report describes a rhesus macaque that had 2 unrelated primary neoplasms. A review of the literature indicates that this rhesus macaque is the first reported to have an adenocarcinoma of the ileocolic junction and multiple hepatic sarcomas simultaneously.
authors.affiliation: Laboratory Animal Services, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. cynthia.lang@jefferson.edu.
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Lang
authors.forename: Judith S
authors.initials: JS
authors.lastname: Daviau
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Merton
authors.forename: Susan M
authors.initials: SM
authors.lastname: Caraker
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D007414:Intestinal Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D012509:Sarcoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*