title: A new tetrahydrofuran lignan diglycoside from Viola tianshanica Maxim.
abstract: A new lignan glycoside, tianshanoside A (1), together with a known phenylpropanoid glycoside, syringin (2) and two known lignan glycosides, picraquassioside C (3), and aketrilignoside B (4), were isolated from the whole plant of Viola tianshanica Maxim. The structure of the new compound was elucidated by extensive NMR (1H, 13C, COSY, HSQC, HMBC and ROESY) and high resolution mass spectrometry analysis. The three lignans 1, 3, and 4 did not exhibit significant cytotoxicity against human gastric cancer Ags cells or HepG2 liver cancer cells. This is the first report of the isolation of a lignan skeleton from the genus Viola L.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. chengzhh@fudan.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qin
authors.forename: Chengle
authors.initials: C
authors.lastname: Yin
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D005663:Furans / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D032413:Viola / Q000737:chemistry*
chemical_list: D005663:Furans; D006027:Glycosides; D017705:Lignans; C018674:tetrahydrofuran