title: Percentage of circulating CD8+ T lymphocytes is associated with albuminuria in type 2 diabetes mellitus.
abstract: T lymphocytes have been demonstrated to play a role in the development of diabetic proteinuria. However, the alteration of circulating T lymphocytes has not been investigated in a type 2 diabetic cohort. A cross-sectional study was conducted in Peking University Aerospace Center Hospital. 510 participants were type 2 diabetes mellitus, 30-70 years of age. Patients with immune disease, medical conditions that affect immune function, infection, or end-organ damage were excluded. The percentage of circulating CD8+ T lymphocytes was significantly associated with albuminuria in the cohort. The impact of albuminuria to CD8+ T lymphocytes in a multivariate linear regression model was indicated by the B- coefficient (95% confidence interval) 1.812 (0.204-3.421, P=0.03). Our data first showed that the percentage of circulating CD8+ T cells is associated with albuminuria in type 2 diabetes mellitus, which may support the rationality of systemic inhibition of T lymphocytes in treating albuminuria in these patients.
authors.affiliation: Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Lei
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Meng
authors.affiliation: Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000209:etiology / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged