title: N-halamine-decorated polystyrene nanoparticles based on 5-allylbarbituric acid: from controllable fabrication to bactericidal evaluation.
abstract: N-halamine-based antibacterial polystyrene nanoparticles with different particle size ranged from 91.5 nm to 562.5 nm were facilely fabricated by surfactant-free emulsion polymerization with 5-allylbarbituric acid served as N-halamine precursor. Effect of experimental parameters such as monomer concentration, initiator concentration, and ionic strength on particle size was investigated systematically. N-halamine-based antibacterial polystyrene nanoparticles showed enhanced antibacterial activity against both Gram-positive species Staphylococcus aureus and Gram-negative species Pseudomonas aeruginosa compared with bulk powder N-halamine. Biocidal activity of N-halamine-based antibacterial polystyrene nanoparticles can be tailored effectively by tuning particle size. Stability and bactericidal activity of N-halamine-based antibacterial polystyrene nanoparticles was detected as a function of extending period.
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China. Electronic address: dongali@imu.edu.cn.
authors.forename: Alideertu
authors.initials: A
authors.lastname: Dong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Shi
authors.initials: S
authors.lastname: Lan
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Sarina
authors.initials: S
authors.lastname: Bao
authors.lastname: Siriguleng
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Fengqi
authors.initials: F
authors.lastname: Liu
authors.forename: Chokto
authors.initials: C
authors.lastname: Harnoode
mesh_terms: D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001463:Barbiturates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D011137:Polystyrenes / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D001463:Barbiturates; D011137:Polystyrenes; C032232:barbituric acid
keywords: 5-Allylbarbituric acid; Bactericidal; Controllable fabrication; N-halamine; Polystyrene