title: An ensemble self-training protein interaction article classifier.
abstract: Protein-protein interaction (PPI) is essential to understand the fundamental processes governing cell biology. The mining and curation of PPI knowledge are critical for analyzing proteomics data. Hence it is desired to classify articles PPI-related or not automatically. In order to build interaction article classification systems, an annotated corpus is needed. However, it is usually the case that only a small number of labeled articles can be obtained manually. Meanwhile, a large number of unlabeled articles are available. By combining ensemble learning and semi-supervised self-training, an ensemble self-training interaction classifier called EST_IACer is designed to classify PPI-related articles based on a small number of labeled articles and a large number of unlabeled articles. A biological background based feature weighting strategy is extended using the category information from both labeled and unlabeled data. Moreover, a heuristic constraint is put forward to select optimal instances from unlabeled data to improve the performance further. Experiment results show that the EST_IACer can classify the PPI related articles effectively and efficiently.
authors.affiliation: School of Information Science, Nanjing Audit University, 86 Yushan Rd(W), 211815, Nanjing, P.R. China. E-mail: yifeichen91@nau.edu.cn.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Hou
authors.forename: Bernard
authors.initials: B
authors.lastname: Manderick
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D057225:Data Mining; D030562:Databases, Protein; D019277:Entropy; D025941:Protein Interaction Mapping / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D012984:Software; D060388:Support Vector Machine
keywords: Interaction article classification; ensemble semi-supervised learning; feature weighting; instance selection