title: A two-layered classifier based on the radial basis function for the screening of thalassaemia.
abstract: The thalassaemias are blood disorders with hereditary transmission. Their distribution is global, with particular incidence in areas affected by malaria. Their diagnosis is mainly based on haematologic and genetic analyses. The aim of this study was to differentiate between persons with the thalassaemia trait and normal subjects by inspecting characteristics of haemochromocytometric data. The paper proposes an original method that is useful in screening activity for thalassaemia classification. A complete working system with a friendly graphical user interface is presented. A unique feature of the presented work is the adoption of a two-layered classification system based on Radial basis function, which improves the performance of the system.
authors.affiliation: University of Sassari, via Piandanna 4, 07100, Sassari, Italy. Electronic address: gilmasala@uniss.it.
authors.forename: G L
authors.initials: GL
authors.lastname: Masala
authors.forename: B
authors.initials: B
authors.lastname: Golosio
authors.forename: R
authors.initials: R
authors.lastname: Cutzu
authors.forename: R
authors.initials: R
authors.lastname: Pola
mesh_terms: D000293:Adolescent; D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D016571:Neural Networks, Computer; D013789:Thalassemia / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology
keywords: K-Nearest neighbours; Probabilistic neural network; Radial basis function; α-Thalassaemia; β-Thalassaemia