title: Possible protective effect of sertraline against cisplatin-induced ototoxicity: an experimental study.
abstract: OBJECTIVE
  Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients. Lots of agents were tried to prevent this, but there is not a routine treatment modality yet. The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats.
  
  
  METHODS
  Experimental animal study.
  
  
  METHODS
  Forty-eight rats were randomly separated in two groups as groups I and II. Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered. In group II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period. Distortion product otoacoustic emission measurements were performed at the first day and the 10th day.
  
  
  RESULTS
  When the ototoxicity rates after cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996 Hz (P < 0.05).
  
  
  CONCLUSIONS
  Sertraline seems to have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that occurred in cancer patients together.
authors.affiliation: Department of Otolaryngology, Kocaeli University, Faculty of Medicine, 41380 Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ozturk
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ucar
authors.forename: Fatih
authors.initials: F
authors.lastname: Sarı
authors.forename: Selvet
authors.initials: S
authors.lastname: Erdogan
authors.forename: Murat
authors.initials: M
authors.lastname: Topdag
authors.forename: Mete
authors.initials: M
authors.lastname: Iseri
mesh_terms: D000158:Acoustic Impedance Tests; D000161:Acoustic Stimulation; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline