title: Diagnostic value of exercise-induced changes in circulating high sensitive troponin T in stable chest pain patients.
abstract: OBJECTIVE
  We investigated the diagnostic value of exercise-induced increase in cardiac Troponin T (cTnT) in stable chest pain subjects.
  
  
  METHODS
  CTnT was measured before and 20 h after an exercise test in 157 subjects suspected of coronary artery disease (CAD).
  
  
  RESULTS
  CAD subjects (n = 41) had higher baseline cTnT levels compared to non-CAD subjects (n = 116), 6.39 ng/l and 3.00 ng/l, respectively, p < 0.0001, and were more likely to increase in cTnT (70.7% versus 27.6%, p < 0.0001). Net Reclassification Index for the combined variable was 19%, p = 0.02.
  
  
  CONCLUSIONS
  Exercise-induced increase in cTnT was found to be associated with CAD and cTnT measurements improved the diagnostic evaluation.
authors.affiliation: Department of Cardiology, Copenhagen University Hospital of Bispebjerg , Copenhagen NV , Denmark .
authors.forename: Mette Rauhe
authors.initials: MR
authors.lastname: Mouridsen
authors.forename: Olav Wendelboe
authors.initials: OW
authors.lastname: Nielsen
authors.forename: Ole Dyg
authors.initials: OD
authors.lastname: Pedersen
authors.forename: Christian Malchau
authors.initials: CM
authors.lastname: Carlsen
authors.forename: Theodoros
authors.initials: T
authors.lastname: Intzilakis
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Binici
authors.forename: Ahmad
authors.initials: A
authors.lastname: Sajadieh
mesh_terms: D000368:Aged; D002637:Chest Pain / Q000175:diagnosis*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T