title: Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery.
abstract: BACKGROUND
  In this study, we have tried to demonstrate the effects of coating style used in oxygenators on various hematologic and clinical parameters.
  
  
  METHODS
  Twenty-seven patients were included in the study, who had undergone operations because of elective coronary artery disease. Albumin-coated oxygenator was used in Group I. In Group II, a synthetic polypeptide-coated oxygenator was used. C1-inhib (complement), C3c, C4, interleukins (IL-1β, IL2, IL-6, IL-10), and tumor necrosis factor alpha (TNF-α) levels were examined at four different time intervals. Hemoglobin, hematocrit, leukocyte and platelet counts, drainage, and transfused blood volumes were analyzed.
  
  
  RESULTS
  Albumin levels were significantly lower in Group I than those in Group II 5 minutes after the removal of the cross-clamp. Twenty-four hours after the surgery, Group I patients also had a significantly higher white blood cell count compared to Group II patients. TNF-α levels in Group I were always expressed in considerably higher amounts than those in Group II. IL-6 levels were significantly higher in Group I, but IL-10 levels were observed to be higher in Group II (p < 0.05).
  
  
  CONCLUSIONS
  Synthetic polypeptide-coated advanced technology, which employed oxygenators, had an important attenuator effect on acute phase reactants and also on the inflammatory response.
authors.affiliation: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey. Electronic address: erdaldr@yahoo.com.
authors.forename: Erdal
authors.initials: E
authors.lastname: Simsek
authors.affiliation: Department of Cardiovascular Surgery, Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Kasim
authors.initials: K
authors.lastname: Karapinar
authors.affiliation: Department of Cardiovascular Surgery, İzzet Baysal University, Bolu, Turkey.
authors.forename: Onursal
authors.initials: O
authors.lastname: Bugra
authors.affiliation: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tulga Ulus
authors.affiliation: Department of Cardiovascular Surgery, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Sarigul
mesh_terms: D000418:Albumins / Q000008:administration & dosage*; D003324:Coronary Artery Disease / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010106:Oxygenators; D010455:Peptides / Q000008:administration & dosage*; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000418:Albumins; C508609:IL10 protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D007376:Interleukin-2; D015850:Interleukin-6; D010455:Peptides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: complement; interleukin; oxygenator; systemic inflammatory response syndrome