title: Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol.
abstract: We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of ~60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.
authors.affiliation: Department of Chemistry and ‡Department of Biotechnology, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Jana
authors.forename: Biswajit
authors.initials: B
authors.lastname: Saha
authors.forename: Deb Ranjan
authors.initials: DR
authors.lastname: Banerjee
authors.forename: Sudip Kumar
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Kim Truc
authors.initials: KT
authors.lastname: Nguyen
authors.forename: Xing
authors.initials: X
authors.lastname: Ma
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Qu
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
authors.forename: N D Pradeep
authors.initials: ND
authors.lastname: Singh
mesh_terms: D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D002699:Chlorambucil / Q000378:metabolism / Q000494:pharmacology; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D062105:Molecular Docking Simulation; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D055668:Photochemical Processes; D010782:Photolysis
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D002699:Chlorambucil