title: [The prevalence and risk factors of occupational asthma in workers exposed to isocyanate].
abstract: OBJECTIVE
  To investigate the prevalence of occupational asthma, airway inflammation and analyze the risk factors for workers exposed to isocyanates.
  
  
  METHODS
  A cross-sectional study was applied. Totally 429 isocyanates exposed workers were surveyed and the prevalence of occupational asthma and airway inflammation situation were examined by questionnaire, physical examination and laboratory tests. Multivariate logistic regression was applied to analyze the possible risk factors of isocyanate-induced occupational asthma.
  
  
  RESULTS
  (1) A total of 366 patients with complete data were included in the study, and finally 11 cases were diagnosed as isocyanate-induced occupational asthma with a prevalence of 3.0%. (2) Neutrophil percentage in the induced sputum of occupational asthma increased significantly [42.00% (34.00%-55.00%) before work and 59.00% (51.00%-70.00%) after work (Z = -2.940. P < 0.05)]. (3) Length of service (OR = 3.096, P = 0.025) and rhinitis (OR = 1.901, P = 0.008) were independent dangerous factors, and protective measures (OR = 0.074, P = 0.015) was protective factors to isocyanate-induced occupational asthma.
  
  
  CONCLUSIONS
  Neutrophilic inflammation can be triggered by isocyanate exposure. Regular health examinations, effective protective measures can reduce the prevalence of isocyanate-induced occupational asthma.
authors.affiliation: Institute of Respiratory Disease, the First Affiliated Hospital of China Medical University, Shenyang 110001, China. Email: konglingf@sina.com.
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: An
authors.forename: Yi-wen
authors.initials: YW
authors.lastname: Jiang
authors.forename: Ling-fei
authors.initials: LF
authors.lastname: Kong
authors.forename: Min-hua
authors.initials: MH
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D059366:Asthma, Occupational / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D017953:Isocyanates