title: Peptide modification by introduction ofα-trifluoromethyl substituted amino acids.
abstract: Methodology for the synthesis and incorporation ofα-trifluoromethyl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation ofα-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolytic stability and lipophilicity. Furthermore, it improves transport rates in vivo and permeability through certain body barriers.
authors.affiliation: Organisch-Chemisches Institut der Universität Leipzig, Talstrasse 35, D-04103, Leipzig, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Sewald
authors.forename: W
authors.initials: W
authors.lastname: Hollweck
authors.forename: K
authors.initials: K
authors.lastname: Mütze
authors.forename: C
authors.initials: C
authors.lastname: Schierlinger
authors.forename: L C
authors.initials: LC
authors.lastname: Seymour
authors.forename: K
authors.initials: K
authors.lastname: Gaa
authors.forename: K
authors.initials: K
authors.lastname: Burger
authors.forename: B
authors.initials: B
authors.lastname: Koksch
authors.forename: H D
authors.initials: HD
authors.lastname: Jakubke