title: Correlates of adverse outcomes in abdominally obese individuals: findings from the five-year followup of the population-based study of health in Pomerania.
abstract: BACKGROUND
  Abdominal obesity is a major risk factor of cardiovascular disease (CVD), type 2 diabetes (T2DM), and premature death. However, it has not been resolved which factors predispose for the development of these adverse obesity-related outcomes in otherwise healthy individuals with abdominal obesity.
  
  
  METHODS
  We studied 1,506 abdominal obese individuals (waist-to-height ratio (WHtR) ≥ 0.5) free of CVD or T2DM from the population-based Study of Health in Pomerania and assessed the incidence of CVD or T2DM after a five-year followup. Logistic regression models were adjusted for major cardiovascular risk factors and liver, kidney diseases, and sociodemographic status.
  
  
  RESULTS
  During follow-up time, we observed 114 and 136 new T2DM and CVD cases, respectively. Regression models identified age, waist circumference, serum glucose, and liver disease as predictors of T2DM. Regarding CVD, only age, unemployment, and a divorced or widowed marital status were significantly associated with incident CVD. In this subgroup of obese individuals blood pressure, serum glucose, or lipids did not influence incidence of T2DM or CVD.
  
  
  CONCLUSIONS
  We identified various factors associated with an increased risk of incident T2DM and CVD among abdominally obese individuals. These findings may improve the detection of high-risk individuals and help to advance prevention strategies in abdominal obesity.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße NK, 17475 Greifswald, Germany ; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 13347 Berlin, Germany.
authors.forename: Nele
authors.initials: N
authors.lastname: Friedrich
authors.forename: Harald J
authors.initials: HJ
authors.lastname: Schneider
authors.forename: Ulrich
authors.initials: U
authors.lastname: John
authors.forename: Marcus
authors.initials: M
authors.lastname: Dörr
authors.forename: Sebastian E
authors.initials: SE
authors.lastname: Baumeister
authors.forename: Georg
authors.initials: G
authors.lastname: Homuth
authors.forename: Uwe
authors.initials: U
authors.lastname: Völker
authors.forename: Henri
authors.initials: H
authors.lastname: Wallaschofski
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008055:Lipids