title: Ultrasound-guided core needle biopsy in diagnosis of abdominal and pelvic neoplasm in pediatric patients.
abstract: BACKGROUND
  Ultrasound-guided core needle biopsy of abdominal and pelvic masses in adults has gained tremendous popularity. However, the application of the same treatment in children is not as popular because of apprehensions regarding inadequate tissues for the biopsy and accidental puncture of vital organs.
  
  
  METHODS
  Data of the application of ultrasound-guided core needle biopsy in 105 pediatric patients with clinically or ultrasound-diagnosed abdominopelvic masses were reviewed. Diagnostic procedures were conducted in our institution from May 2011 to May 2013.
  
  
  RESULTS
  The biopsies were conducted on 86 malignant lesions and 19 benign lesions. 86 malignant tumors comprised neuroblastomas (30 cases), hepatoblastomas (15 cases), nephroblastomas (11 cases), and primitive neuroectodermal tumors/malignant small round cells (6 cases). Among malignant tumor cases, only a pelvic primitive neuroectodermal tumor did not receive a pathological diagnosis. Therefore, the biopsy accuracy was 98.8 % in malignant tumor. However, the biopsies for one neuroblastomas and one malignant small round cell tumor were inadequate for cytogenetic analysis. Therefore, 96.5 % of the malignant tumor patients received complete diagnosis via biopsy. 19 benign tumors comprised mature teratoma (10 cases), hemangioendothelioma (3 cases), paraganglioma (2 cases), and infection (2 cases). The diagnostic accuracy for benign neoplasm was 100 %. Five patients experienced postoperative complications, including pain (2 patients), bleeding from the biopsy site (2 patients), and wound infection (1 patient).
  
  
  CONCLUSIONS
  Ultrasound-guided core needle biopsy is an efficient, minimally invasive, accurate, and safe diagnostic method that can be applied in the management of abdominal or pelvic mass of pediatric patients.
authors.affiliation: Department of Ultrasonic Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Hailing
authors.initials: H
authors.lastname: Wang
authors.forename: Fangxuan
authors.initials: F
authors.lastname: Li
authors.forename: Juntian
authors.initials: J
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000005:Abdomen / Q000473:pathology*; D000008:Abdominal Neoplasms / Q000175:diagnosis*; D000293:Adolescent; D062005:Biopsy, Large-Core Needle; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D018197:Hepatoblastoma / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis; D010372:Pediatrics / Q000379:methods; D010386:Pelvic Neoplasms / Q000175:diagnosis*; D010388:Pelvis / Q000473:pathology*; D015203:Reproducibility of Results; D018084:Ultrasonography, Interventional / Q000379:methods*; D009396:Wilms Tumor / Q000175:diagnosis