title: Development of a Standard Reference Material for metabolomics research.
abstract: The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.
authors.affiliation: Biomolecular Measurement Division, #Chemical Sciences Division, and □Biosystems and Biomaterials Division, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Phinney
authors.forename: Guillaume
authors.initials: G
authors.lastname: Ballihaut
authors.forename: Mary
authors.initials: M
authors.lastname: Bedner
authors.forename: Brandi S
authors.initials: BS
authors.lastname: Benford
authors.forename: Johanna E
authors.initials: JE
authors.lastname: Camara
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Christopher
authors.forename: W Clay
authors.initials: WC
authors.lastname: Davis
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Dodder
authors.forename: Gauthier
authors.initials: G
authors.lastname: Eppe
authors.forename: Brian E
authors.initials: BE
authors.lastname: Lang
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Long
authors.forename: Mark S
authors.initials: MS
authors.lastname: Lowenthal
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: McGaw
authors.forename: Karen E
authors.initials: KE
authors.lastname: Murphy
authors.forename: Bryant C
authors.initials: BC
authors.lastname: Nelson
authors.forename: Jocelyn L
authors.initials: JL
authors.lastname: Prendergast
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Reiner
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Rimmer
authors.forename: Lane C
authors.initials: LC
authors.lastname: Sander
authors.forename: Michele M
authors.initials: MM
authors.lastname: Schantz
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Sharpless
authors.forename: Lorna T
authors.initials: LT
authors.lastname: Sniegoski
authors.forename: Susan S-C
authors.initials: SS
authors.lastname: Tai
authors.forename: Jeanice B
authors.initials: JB
authors.lastname: Thomas
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Vetter
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Welch
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Wise
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Wood
authors.forename: William F
authors.initials: WF
authors.lastname: Guthrie
authors.forename: Charles R
authors.initials: CR
authors.lastname: Hagwood
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Leigh
authors.forename: James H
authors.initials: JH
authors.lastname: Yen
authors.forename: Nien-Fan
authors.initials: NF
authors.lastname: Zhang
authors.forename: Madhu
authors.initials: M
authors.lastname: Chaudhary-Webb
authors.forename: Huiping
authors.initials: H
authors.lastname: Chen
authors.forename: Zia
authors.initials: Z
authors.lastname: Fazili
authors.forename: Donna J
authors.initials: DJ
authors.lastname: LaVoie
authors.forename: Leslie F
authors.initials: LF
authors.lastname: McCoy
authors.forename: Shahzad S
authors.initials: SS
authors.lastname: Momin
authors.forename: Neelima
authors.initials: N
authors.lastname: Paladugula
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Pendergrast
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pfeiffer
authors.forename: Carissa D
authors.initials: CD
authors.lastname: Powers
authors.forename: Daniel
authors.initials: D
authors.lastname: Rabinowitz
authors.forename: Michael E
authors.initials: ME
authors.lastname: Rybak
authors.forename: Rosemary L
authors.initials: RL
authors.lastname: Schleicher
authors.forename: Bridgette M H
authors.initials: BM
authors.lastname: Toombs
authors.forename: Mary
authors.initials: M
authors.lastname: Xu
authors.forename: Mindy
authors.initials: M
authors.lastname: Zhang
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Castle
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000592:standards*; D002338:Carotenoids / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D055432:Metabolomics / Q000592:standards*; D009316:National Institutes of Health (U.S.); D012015:Reference Standards; D014481:United States; D014815:Vitamins / Q000097:blood
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D005227:Fatty Acids; D014815:Vitamins; D002338:Carotenoids