title: Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies.
abstract: In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. bpasche@uabmc.edu.
authors.forename: Jacquelyn W
authors.initials: JW
authors.lastname: Zimmerman
authors.forename: Hugo
authors.initials: H
authors.lastname: Jimenez
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pennison
authors.forename: Ivan
authors.initials: I
authors.lastname: Brezovich
authors.forename: Desiree
authors.initials: D
authors.lastname: Morgan
authors.forename: Albert
authors.initials: A
authors.lastname: Mudry
authors.forename: Frederico P
authors.initials: FP
authors.lastname: Costa
authors.forename: Alexandre
authors.initials: A
authors.lastname: Barbault
authors.forename: Boris
authors.initials: B
authors.lastname: Pasche
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000628:therapy; D049109:Cell Proliferation / Q000528:radiation effects; D004574:Electromagnetic Fields; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy; D055909:Magnetic Field Therapy / Q000009:adverse effects; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D011829:Radiation Dosage; D011846:Radio Waves; D013964:Thyroid Neoplasms / Q000628:therapy; D016896:Treatment Outcome