title: Lymphocytes T and B in rabbits infected with RHD virus.
abstract: The aim of this study was to determine the differences in immunological response of animals infected with different antigenic variants of the virus--three haemagglutinating (Vt97, Triptis, Hartmannsdorf) and two non-haemagglutinating (Pv97, 9905 RHDVa). The specific immunological response was measured by the dynamics of changes in the amount of lymphocytes T (with CD5+, CD4+, CD8+, CD25+ receptor) and B (with CD19+ receptor). The study showed differences in immunogenicity of the analysed RHDV antigenic variants, which allowed them to be divided into groups of: more immunogenic strains, including non-haemagglutinating 9905 RHDVa and haemagglutinating Vt97 and Triptis variants; and less immunogenic strains, including the haemagglutinating Hartmannsdorf variant and the non-haemagglutinating Pv97 variant. Such a result may indicate that the agglutination capacity of red blood cells might not be a factor impacting the number of T and B lymphocytes.
authors.affiliation: Department of Immunology, Faculty of Biology University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland. paulina.niedzwiedzka@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Niedźwiedzka-Rystwej
authors.forename: B
authors.initials: B
authors.lastname: Tokarz-Deptuła
authors.forename: W
authors.initials: W
authors.lastname: Deptuła
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000145:classification / Q000502:physiology*; D017250:Caliciviridae Infections / Q000276:immunology / Q000662:veterinary*; D005260:Female; D014644:Genetic Variation; D006384:Hemagglutination; D017929:Hemorrhagic Disease Virus, Rabbit / Q000145:classification* / Q000235:genetics / Q000276:immunology; D007111:Immunity, Cellular; D008297:Male; D011817:Rabbits; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology*
chemical_list: D000956:Antigens, Viral