title: Fabrication of anticoagulation layer on titanium surface by sequential immobilization of poly (ethylene glycol) and albumin.
abstract: This paper presents a simple method to sequentially immobilize poly (ethylene glycol) (PEG) and albumin on titanium surface to enhance the blood compatibility. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated that PEG and albumin were successfully immobilized on the titanium surface. Water contact angle results showed a better hydrophilic surface after the immobilization. The immobilized PEG or albumin can not only obviously prevent platelet adhesion and activation but also prolong activated partial thromboplastin time (APTT), leading to the improved anticoagulation. Moreover, immobilization of albumin on PEG-modified surface can further improve the anticoagulation. The approach in the present study provides an effective and efficient method to improve the anticoagulation of blood-contact biomedical devices such as coronary stents.
authors.affiliation: Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, P.R. China.
authors.forename: Chang-Jiang
authors.initials: CJ
authors.lastname: Pan
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Hou
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Zhang
authors.forename: Lin-Cai
authors.initials: LC
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D000418:Albumins / Q000737:chemistry*; D000925:Anticoagulants / Q000737:chemistry*; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000378:metabolism; D020099:Coated Materials, Biocompatible; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010314:Partial Thromboplastin Time; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D015607:Stents; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000418:Albumins; D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D014867:Water; D011092:Polyethylene Glycols; D014025:Titanium
keywords: PEG; Titanium; albumin; anticoagulation; surface modification