title: Quantitative diagnosis of salivary gland tumors with contrast-enhanced ultrasound--a preliminary study.
abstract: OBJECTIVE
  To quantitatively analyze the value of qualitative diagnosis of salivary gland masses with contrast-enhanced ultrasound (CEUS).
  
  
  METHODS
  The enhanced sonographic features of 68 salivary gland masses were analyzed to differentiate them. The final diagnoses were confirmed by biopsy pathology.
  
  
  RESULTS
  We observed from the perfusion kinetics of CEUS that most pleomorphic adenomas manifested lower enhancement and well-defined margins; most Warthin tumors presented with higher enhancement and well-defined margins; and most malignant tumors had higher enhancement and poorly defined margins. Their time-intensity curves showed pleomorphic adenomas were hypovascularized with a poor perfusion, whereas Warthin tumors and malignant tumors were hypervascularized with a rich perfusion. Additionally, malignant tumors showed significantly shortened time to peak and richer maximum signal intensity compared with Warthin tumors.
  
  
  CONCLUSIONS
  The features of salivary gland masses identified with CEUS were helpful in the differential diagnosis of salivary gland masses.
authors.affiliation: Ultrasound Department, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Zunyi Medical University, Chengdu, Sichuan, China.
authors.forename: Jia-mei
authors.initials: JM
authors.lastname: Gou
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
authors.forename: Ying-xian
authors.initials: YX
authors.lastname: Liu
mesh_terms: D000235:Adenolymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000000981:diagnostic imaging* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D013459:Sulfur Hexafluoride; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride