title: Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents.
abstract: A number of cyclic peptides including [FR]4, [FK]4, [WR]4, [CR]4, [AK]4, and [WK]n(n = 3-5) containing L-amino acids were produced using solid-phase peptide synthesis. We hypothesized that an optimal balance of hydrophobicity and charge could generate self-assembled nanostructures in aqueous solution by intramolecular and/or intermolecular interactions. Among all the designed peptides, [WR]n(n = 3-5) generated self-assembled vesicle-like nanostructures at room temperature as shown by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and/or dynamic light scattering (DLS). This class of peptides represents the first report of surfactant-like cyclic peptides that self-assemble into nanostructures. A plausible mechanistic insight into the self-assembly of [WR]5was obtained by molecular modeling studies. Modified [WR]5analogues, such as [WMeR]5, [WR(Me)2]5, [WMeR(Me)2]5, and [WdR]5, exhibited different morphologies to [WR]5as shown by TEM observations. [WR]5exhibited a significant stabilizing effect for generated silver nanoparticles and glyceraldehyde-3-phosphate dehydrogenase activity. These studies established a new class of surfactant-like cyclic peptides that self-assembled into nanostructures and could have potential applications for the stabilization of silver nanoparticles and protein biomolecules.
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.
authors.forename: Dindyal
authors.initials: D
authors.lastname: Mandal
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.|One University Drive, School of Pharmacy, Chapman University, Orange, California 92866, USA.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Tiwari
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.
authors.forename: Amir Nasrolahi
authors.initials: AN
authors.lastname: Shirazi
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.
authors.forename: Donghoon
authors.initials: D
authors.lastname: Oh
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Ye
authors.affiliation: Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahuji Maharaj University, Kanpur 208024, India.
authors.forename: Antara
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahuji Maharaj University, Kanpur 208024, India.
authors.forename: Arpita
authors.initials: A
authors.lastname: Yadav
authors.affiliation: 7 Greenhouse Road, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, USA.|One University Drive, School of Pharmacy, Chapman University, Orange, California 92866, USA.
authors.forename: Keykavous
authors.initials: K
authors.lastname: Parang