title: Wireless-electrodeless quartz-crystal-microbalance biosensors for studying interactions among biomolecules: a review.
abstract: The mass sensitivity of quartz-crystal microbalance (QCM) was drastically improved by removing electrodes and wires attached on the quartz surfaces. Instead of wire connections, intended vibrations of quartz oscillators were excited and detected by antennas through electromagnetic waves. This noncontacting measurement is the key for ultrahigh-sensitive detection of proteins in liquids as well as quantitative measurements. This review shows the principle of wireless QCMs, their applications to studying interactions among biomolecules and aggregation reactions of amyloid β peptides, and the next-generation MEMS QCM, the resonance acoustic microbalance with naked embedded quartz (RAMNE-Q).
authors.affiliation: Graduate School of Engineering, Osaka University.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ogi
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D058525:Quartz Crystal Microbalance Techniques / Q000295:instrumentation / Q000379:methods*; D059015:Wireless Technology
chemical_list: D016229:Amyloid beta-Peptides