title: Prospective relationship between hemispheric lateralisation and CD4+ T cells in human immunodeficiency virus type 1.
abstract: OBJECTIVE
  Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders.
  
  
  METHODS
  Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication).
  
  
  RESULTS
  Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts.
  
  
  CONCLUSIONS
  Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided.
authors.affiliation: Centre for Rehabilitation Research,Brunel University, Uxbridge, UK.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Sumner
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Nowicky
authors.forename: Andrew
authors.initials: A
authors.lastname: Parton
authors.forename: Carolien
authors.initials: C
authors.lastname: Wylock
authors.forename: Renata
authors.initials: R
authors.lastname: Cserjesi
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fischler
authors.forename: Patrick
authors.initials: P
authors.lastname: Lacor
authors.forename: Yori
authors.initials: Y
authors.lastname: Gidron
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013223:Statistics as Topic