title: Mild cognitive impairment: risk of dementia according to subtypes.
abstract: Mild cognitive impairment (MCI) has 3 clinical subtypes: amnestic (aMCI), multiple domains (mdMCI) and non-amnestic single domain (na-SD-MCI) whose evolutive possibility to dementia has not been profoundly studied.
  
  
  OBJECTIVE
  This paper aims to determine the conversion to dementia of the different subtypes of MCI and determine risk factors associated to conversion to dementia.
  
  
  METHODS
  A total of 127 patients diagnosed with MCI (age=70.21; SD=13.17) were evaluated with a neuropsychological and neuropsychiatric battery. They were classified into 3 groups: amnestic MCI (n=20), multiple-domain MCI (n=98), non-amnestic MCI (n=9). Seventeen normal subjects (age=74.59; SD=10.63) were included.
  
  
  RESULTS
  Of those included, 27.1% developed Alzheimer's type dementia [average time for conversion to Alzheimer's dementia (AD) 11.12 months (SD=0.183)]. None of the controls developed dementia. Thirty-five percent (n=7) of amnestic MCI converted to AD: 20% (n=4) at 6 months and 15% (n=3) at 12 months); 11.1% (n=1) of the non-amnestic single domain MCI converted to AD at 6 months. It was found that 31.6% (n=31) of multiple domain MCI rotated to AD: 15.3% (n=15) at 6 months and 16.3% (n=16) at 12 months. Age (p<0.05, β=1.03) increased the likelihood of rotation to AD. Multi-domain MCI subtype was the most frequent. However, the conversion to dementia in amnestic subtype was the highest, age and retirement being the variables that increased the likelihood of conversion to Dementia.
authors.affiliation: Laboratorio De Investigación De La Memoria Hospital Abel Zubizarreta, Buenos Aires Servicio de Investigación y Rehabitación Neurocognitiva-SIREN-CEMIC.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Serrano
authors.forename: Carol
authors.initials: C
authors.lastname: Dillon
authors.forename: Adriana
authors.initials: A
authors.lastname: Leis
authors.forename: Fernando E
authors.initials: FE
authors.lastname: Taragano
authors.forename: Ricardo Francisco
authors.initials: RF
authors.lastname: Allegri
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000150:complications*; D003704:Dementia / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors