title: A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children.
abstract: OBJECTIVE
  the low degree of inflammation in obesity contributes to systemic metabolic dysfunction. Recent experimental studies proposed some effects of alteration in gut microbiota on inflammatory factors. This study aimed to assess the anti-inflammatory effects of a synbiotic supplement on inflammation markers in overweight and obese children and adolescents.
  
  
  METHODS
  this randomized triple-masked controlled trial was conducted among 70 participants aged 6 to 18 years, with a body mass index (BMI) equal or higher than the 85th percentile. They were randomly assigned into two groups of equal number to receive synbiotic or placebo for eight weeks.
  
  
  RESULTS
  fifty-six of 70 participants (80%) completed the study. Compared with the placebo group, the synbiotic group had significant decrease in mean values of tumor necrosis-α and interleukin-6, with significant increase in adiponectin; these changes were no longer significant after adjustment for BMI. There was no significant change in the mean values of high-sensitive C-reactive protein.
  
  
  CONCLUSIONS
  the present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children.
authors.affiliation: Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.affiliation: School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: farajian.sanam@gmail.com.
authors.forename: Sanam
authors.initials: S
authors.lastname: Farajian
authors.affiliation: School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Safavi
authors.affiliation: Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mirlohi
authors.affiliation: Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Hashemipour
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D015340:Epidemiologic Research Design; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D050177:Overweight / Q000178:diet therapy / Q000378:metabolism; D058616:Synbiotics; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015431:Weight Loss
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: Children and adolescents; Crianças e adolescentes; Ensaio clínico; Inflamação; Inflammation; Obesidade; Obesity; Simbiótico; Synbiotic; Trial