title: An observational longitudinal study of the impact of sleeve gastrectomy on glycemic control in type 2 diabetes mellitus.
abstract: BACKGROUND
  Laparoscopic sleeve gastrectomy is increasingly being acknowledged as an effective independent bariatric procedure for obese persons with type 2 diabetes. Data on laparoscopic sleeve gastrectomy from India on this group of patients are limited. This study presents 12-month follow-up data of laparoscopic sleeve gastrectomy on obese Indian patients with type 2 diabetes.
  
  
  METHODS
  In total, 43 obese patients with type 2 diabetes who received sleeve gastrectomy surgery in the Department of Bariatric Surgery, Medanta the Medicity, Gurgaon, India, were evaluated prospectively for a period of 1 year.
  
  
  RESULTS
  Seven patients missed follow-up visits, and one patient died, leaving 35 patients who were analyzed. The mean glycated hemoglobin (HbA1c) levels at baseline and 12 months after surgery were 7.94±1.9% and 5.80±0.7%, respectively (P<0.001). Of these, 77.14% reached the primary end point of HbA1c level ≤6% without medication. HbA1c level at target (i.e., <7%) occurred in 91.4%. The mean body weight decreased from 122.08±23.32 kg to 83.43±15.12 kg at 12 months (P<0.001). The percentage of weight loss and percentage of excess weight loss at 12 months were 31.14±7.8% and 61.52±15%, respectively. Antidiabetes medication use decreased from 88.57% to 11.4%.
  
  
  CONCLUSIONS
  Laparoscopic sleeve surgery is a safe and effective treatment option among the obese Indian type 2 diabetes population with significant remission rates. Follow-up studies are necessary to assess the long-term durability of these results.
authors.affiliation: Division of Endocrinology and Diabetes, Medanta the Medicity , Gurgaon, India .
authors.forename: Arundhati
authors.initials: A
authors.lastname: Dasgupta
authors.forename: Jasjeet
authors.initials: J
authors.lastname: Wasir
authors.forename: Maria
authors.initials: M
authors.lastname: Beloyartseva
authors.forename: Sandeep
authors.initials: S
authors.lastname: Malhotra
authors.forename: Ambrish
authors.initials: A
authors.lastname: Mithal
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007194:India / Q000453:epidemiology; D010535:Laparoscopy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery*; D011446:Prospective Studies; D012074:Remission Induction; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human