title: Aberrant signaling pathways in glioma.
abstract: Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12-15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-8641, Japan. nakada@ns.m.kanazawa-u.ac.jp.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kita
authors.forename: Takuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Lei
authors.initials: L
authors.lastname: Teng
authors.forename: Ilya V
authors.initials: IV
authors.lastname: Pyko
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Hamada