title: Prospective memory in schizophrenia: relationship to medication management skills, neurocognition, and symptoms in individuals with schizophrenia.
abstract: OBJECTIVE
  Impaired adherence to medication regimens is a serious concern for individuals with schizophrenia linked to relapse and poorer outcomes. One possible reason for poor adherence to medication is poor ability to remember future intentions, labeled prospective memory skills. It has been demonstrated in several studies that individuals with schizophrenia have impairments in prospective memory that are linked to everyday life skills. However, there have been no studies, to our knowledge, examining the relationship of a clinical measure of prospective memory to medication management skills, a key element of successful adherence.
  
  
  METHODS
  In this Study 41 individuals with schizophrenia and 25 healthy adults were administered a standardized test battery that included measures of prospective memory, medication management skills, neurocognition, and symptoms.
  
  
  RESULTS
  Individuals with schizophrenia demonstrated impairments in prospective memory (both time and event-based) relative to healthy controls. Performance on the test of prospective memory was correlated with the standardized measure of medication management in individuals with schizophrenia. Moreover, the test of prospective memory predicted skills in medication adherence even after measures of neurocognition were accounted for.
  
  
  CONCLUSIONS
  This suggests that prospective memory may play a key role in medication management skills and thus should be a target of cognitive remediation programs.
authors.affiliation: Department of Psychology.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Raskin
authors.affiliation: Department of Clinical and Health Psychology, University of Florida.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Maye
authors.affiliation: Neuroscience Program, Trinity College.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rogers
authors.affiliation: Neuroscience Program, Trinity College.
authors.forename: David
authors.initials: D
authors.lastname: Correll
authors.affiliation: Neuroscience Program, Trinity College.
authors.forename: Marta
authors.initials: M
authors.lastname: Zamroziewicz
authors.affiliation: Department of Psychology, Wesleyan University.
authors.forename: Matthew
authors.initials: M
authors.lastname: Kurtz
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008569:Memory Disorders / Q000209:etiology*; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D018709:Statistics, Nonparametric; D055815:Young Adult