title: [A case of advanced signet ring cell carcinoma of the appendix that responded to S-1 and docetaxel].
abstract: A 68-year-old man was admitted to our hospital after testing positive in a fecal occult blood test. He was subsequently diagnosed with advanced signet ring cell carcinoma of the appendix with disseminated peritoneal disease and ascites. Weekly chemotherapy with S-1 was commenced, and after three courses, the tumor shrunk in size and the ascites decreased. Two more courses were administered;however, disease progression was noted because of increasing ascites. The chemotherapy regimen was changed to weekly docetaxel, and after two courses, further tumor shrinkage and a decrease in ascites were noted. The disease course of this patient suggests that S-1 and docetaxel were effective against signet ring cell carcinoma of the appendix. Here we report this case and discuss the relevant literature.
authors.affiliation: Division of Surgery, Ina Central Hospital.
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshizawa
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Shirozaki
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Inoue
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maruyama
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Karasawa
authors.forename: Ataru
authors.initials: A
authors.lastname: Nakayama
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Norio
authors.initials: N
authors.lastname: Ito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001063:Appendiceal Neoplasms / Q000188:drug therapy*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy*; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D043823:Taxoids / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid