title: A concise enantioselective synthesis of the guaiane sesquiterpene (-)-oxyphyllol.
abstract: (-)-Oxyphyllol was prepared in only 4 steps from an epoxy enone that already served as an intermediate for the total synthesis of the anticancer guaiane (-)-englerin A. A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions.
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Zahel
authors.forename: Peter
authors.initials: P
authors.lastname: Metz
keywords: asymmetric synthesis; hydration; natural products; terpenes; transannular epoxide opening