title: Thrombocytopenia and thrombosis: a double-edged sword.
abstract: Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopenia can sometimes result in bleeding. There are no evidence-based guidelines regarding the management of a patient with severe thrombocytopenia associated with a major thrombotic manifestation. In this case report, we review the literature reporting the difficulties in management of such patient.
authors.affiliation: Department of Medicine, Division of Rheumatology, Medical University of Southern Africa, MEDUNSA 0204, P O Box 625, Pretoria, South Africa, mtlnyo@gmail.com.
authors.forename: Myat Tun Lin
authors.initials: MT
authors.lastname: Nyo
authors.forename: Asgar Ali
authors.initials: AA
authors.lastname: Kalla
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001921:Brain / Q000000981:diagnostic imaging*; D003240:Connective Tissue Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology*; D013921:Thrombocytopenia / Q000209:etiology*; D014057:Tomography, X-Ray Computed