title: Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.
abstract: Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: mko2@cdc.gov.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Lo
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
authors.forename: Brian H
authors.initials: BH
authors.lastname: Bird
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: Anasuya
authors.initials: A
authors.lastname: Chattopadhyay
authors.affiliation: Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
authors.forename: Clifton P
authors.initials: CP
authors.lastname: Drew
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
authors.forename: Brock E
authors.initials: BE
authors.lastname: Martin
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
authors.forename: Joann D
authors.initials: JD
authors.lastname: Coleman
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: John K
authors.initials: JK
authors.lastname: Rose
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
authors.forename: Stuart T
authors.initials: ST
authors.lastname: Nichol
authors.affiliation: Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: ccs8@cdc.gov.
authors.forename: Christina F
authors.initials: CF
authors.lastname: Spiropoulou
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004337:Drug Carriers; D045464:Henipavirus Infections / Q000517:prevention & control*; D008647:Mesocricetus; D045405:Nipah Virus / Q000235:genetics / Q000276:immunology*; D016019:Survival Analysis; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D018116:Vesiculovirus / Q000235:genetics*; D015678:Viral Structural Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*
chemical_list: D004337:Drug Carriers; D014614:Vaccines, Synthetic; D015678:Viral Structural Proteins; D014765:Viral Vaccines
keywords: Hamster; Henipavirus; Nipah; Single-dose; VSV; Vaccine