title: Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice.
abstract: Ixeris dentata (ID) is an herbal medicine used in Asian countries to treat indigestion, pneumonia, hepatitis, contusions, and tumors; however, its effect on intestinal inflammation is unknown. Thus, we investigated the effect of ID in the dextran sulfate sodium (DSS) model of colitis in female BALB/c mice; animals were evaluated after seven days of DSS treatment. DSS-treated mice showed considerable clinical signs, including weight loss, reduced colon length, colonic epithelial injury, infiltration of inflammatory cells in the colon tissue, and upregulation of inflammatory mediators. However, administration of ID attenuated body weight loss, colon shortening, and the increase in disease activity index score. ID also significantly decreased the colonic mucosal injury and the number of infiltrating mast cells. Moreover, ID inhibited the expressions of cyclooxygenase-2 and hypoxia-inducible factor-1 α in colon tissue. Taken together, the results provide experimental evidence that ID might be a useful therapy for patients with ulcerative colitis.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Dae-Seung
authors.initials: DS
authors.lastname: Kim
authors.forename: Jang-Ho
authors.initials: JH
authors.lastname: Ko
authors.forename: Yong-Deok
authors.initials: YD
authors.lastname: Jeon
authors.forename: Yo-Han
authors.initials: YH
authors.lastname: Han
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Amrit
authors.initials: A
authors.lastname: Poudel
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Jung
authors.forename: Sae-Kwang
authors.initials: SK
authors.lastname: Ku
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Jin-Han
authors.initials: JH
authors.lastname: Park
authors.forename: Byung-Min
authors.initials: BM
authors.lastname: Choi
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Park
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Um
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong