title: Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD.
abstract: Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunesuppressive effects. We cotransplanted the culture-expanded third-party donor-derived umbilical cord MSCs (UC-MSCs) in 21 young people with severe aplastic anemia (SAA) undergoing haplo-HSCT without T-cell-depleted. We observed that all patients had sustained hematopoietic engraftment without any adverse UC-MSC infusion-related events. Furthermore, we did not observe any increase in severe aGVHD. These data suggest that UC-MSCs, possibly thanks to their potent immunosuppressive effect on allo-reactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure and severe GVHD in haplo-HSCT.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Yan
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Zhouyang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048, China. Electronic address: xiongwuxiao@sohu.com.
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Chunji
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wanming
authors.initials: W
authors.lastname: Da
authors.affiliation: TEDA Research Center of Life Science and Technology, State Key Laboratory of Experimental Hematology, Institute of Hematology, Tianjin 300020, China.
authors.forename: Zhongchao
authors.initials: Z
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006238:Haploidy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012720:Severity of Illness Index; D014184:Transplantation, Homologous; D014470:Umbilical Cord / Q000166:cytology; D055815:Young Adult