title: The liver graft as Trojan horse-multilineage donor-derived hematopoiesis after liver transplantation: case report.
abstract: Hematopoietic macrochimerism, which is rarely seen after orthotopic liver transplantation (OLT), has been linked to the development of graft versus host disease (GvHD). We report on a patient with GvHD after OLT in whom full engraftment of donor-derived, multilineage hematopoiesis occurred, indicating that the liver contains pluripotent hematopoietic progenitor cells (HPC) capable to restore hematopoiesis in recipients. Although preventing graft rejection, standard immunosuppressive therapy may be under certain immunological conditions not sufficient to prevent GvHD. Age-, disease-, and treatment-related variables might be critical determinants for the development of an effective alloreactive T-cell response leading to the establishment of full hematopoietic chimerism.
authors.affiliation: Clinical Department of General and Transplant Surgery, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Mark
authors.forename: R
authors.initials: R
authors.lastname: Ollinger
authors.forename: H
authors.initials: H
authors.lastname: Rumpold
authors.forename: D
authors.initials: D
authors.lastname: Wolf
authors.forename: D
authors.initials: D
authors.lastname: Nachbaur
authors.forename: F
authors.initials: F
authors.lastname: Aigner
authors.forename: C
authors.initials: C
authors.lastname: Margreiter
authors.forename: C
authors.initials: C
authors.lastname: Gassner
authors.forename: H
authors.initials: H
authors.lastname: Schennach
authors.forename: I
authors.initials: I
authors.lastname: Graziadei
authors.forename: W
authors.initials: W
authors.lastname: Vogel
authors.forename: R
authors.initials: R
authors.lastname: Margreiter
authors.forename: E
authors.initials: E
authors.lastname: Gunsilius
mesh_terms: D000368:Aged; D019070:Cell Lineage; D006410:Hematopoiesis; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D014019:Tissue Donors