title: Intravesical glycosaminoglycans for obstructive feline idiopathic cystitis: a pilot study.
abstract: Feline idiopathic cystitis is a common condition, often resulting in repeated episodes of life-threatening urethral obstruction. Defective urinary bladder glycosaminoglycans have been implicated as a causal factor. In this report, a commercially available glycosaminoglycan product was infused into the urinary bladders of cats with urethral obstruction from idiopathic cystitis to study the effect on repeated obstruction. In this randomized, blind, placebo-controlled clinical trial, the therapeutic protocol was well tolerated with no adverse effects. Whereas no glycosaminoglycan-treated cats (n = 9) developed repeated urethral obstruction during the 7 day follow-up period, 3/7 placebo-treated cats developed repeated obstructions. Approaching statistical significance (P = 0.06), these data suggest that further investigation of this new treatment option is warranted.
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA allison.bradley@colostate.edu.
authors.forename: Allison M
authors.initials: AM
authors.lastname: Bradley
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lappin
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003556:Cystitis / Q000188:drug therapy / Q000662:veterinary*; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D016896:Treatment Outcome; D014524:Urethral Obstruction / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D006025:Glycosaminoglycans