title: Relationship of amino acid sequence to immunological activity - syntheses and structure-activity relationships of thymosinβ 4 family.
abstract: Four peptides related to thymosinβ 4 family and its six fragments were synthesized by the solution method. Among them, the four peptides related to thymosinβ 4 family and its two fragments were found to have restoring activity on the impaired blastogenic response of T-lymphocytes isolated from uremic patients, but the other four fragments had no effect. Studies on the structureactivity relationships suggest that the tricosapeptide moiety corresponding to amino acids 16-38 of thymosinβ 4 is found to be an important moiety on impaired immunological deficiency.
authors.affiliation: Kidney Research Laboratory, Kojinkai, 1-6, Tsutsujigaoka 2-chome, Miyagino-Ku, 980, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Abiko
authors.forename: H
authors.initials: H
authors.lastname: Sekino