title: Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography.
abstract: We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ∼47  kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195bUniversity of Dundee, School of Engineering, Physics and Mathematics, Dundee DD1 4HN, Scotland, UK.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Song
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Huang
authors.forename: Thu-Mai
authors.initials: TM
authors.lastname: Nguyen
authors.forename: Emily Y
authors.initials: EY
authors.lastname: Wong
authors.forename: Bastien
authors.initials: B
authors.lastname: Arnal
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000362:Agar; D001696:Biomechanical Phenomena; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
chemical_list: D000362:Agar