title: Bioactive lipids in pathological retinopathy.
abstract: Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.
authors.affiliation: a Department of Food Science and Nutrition , Zhejiang University , Hangzhou , 310029 , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Shen
authors.forename: Sheng-Rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Undurti N
authors.initials: UN
authors.lastname: Das
mesh_terms: D000893:Anti-Inflammatory Agents; D016207:Cytokines / Q000502:physiology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005228:Fatty Acids, Essential / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000502:physiology*; D044045:Lipoxins / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D011091:Polyesters; D017382:Reactive Oxygen Species; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005228:Fatty Acids, Essential; D008055:Lipids; D044045:Lipoxins; D011091:Polyesters; D017382:Reactive Oxygen Species; D042461:Vascular Endothelial Growth Factor A; C121059:poly(lactide-co-trimethylene carbonate); D040301:Vascular Endothelial Growth Factor Receptor-2