title: The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients.
abstract: Objective. To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods. The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS. The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients. The levels of TNF- α , IL-6, and 8-isoprostane F2 α were measured by ELISA. Results. A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group. No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. However, SBP , pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group. The hs-CRP, TNF- α , and IL-6 levels were elevated in both groups but showed no significant differences. Conclusions. Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis. The roles of hypertension and oxidative stress may be more important.
authors.affiliation: Department of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Ren
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Luan
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Luo
authors.forename: Shujing
authors.initials: S
authors.lastname: Han
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Wang
authors.initials: W
authors.lastname: Rui
authors.forename: Yan
authors.initials: Y
authors.lastname: Li