title: ADN-1184 a monoaminergic ligand with 5-HT(6/7) receptor antagonist activity: pharmacological profile and potential therapeutic utility.
abstract: OBJECTIVE
  Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD.
  
  
  METHODS
  We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD.
  
  
  RESULTS
  ADN-1184 exhibits substantial 5-HT6 /5-HT7 /5-HT2A /D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg(-1) i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg(-1) i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg(-1) ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg(-1) i.p.).
  
  
  CONCLUSIONS
  ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia.
authors.affiliation: Adamed Ltd, Czosnów, Poland; Faculty of Pharmacy, Jagiellonian University Collegium Medicum, Cracow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kołaczkowski
authors.forename: P
authors.initials: P
authors.lastname: Mierzejewski
authors.forename: P
authors.initials: P
authors.lastname: Bieńkowski
authors.forename: A
authors.initials: A
authors.lastname: Wesołowska
authors.forename: A
authors.initials: A
authors.lastname: Newman-Tancredi
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D016466:CHO Cells; D003412:Cricetulus; D016291:Dizocilpine Maleate / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D007555:Isoxazoles / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: C000592312:ADN-1184; D014150:Antipsychotic Agents; D007555:Isoxazoles; D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013449:Sulfonamides; D016291:Dizocilpine Maleate
keywords: ADN-1184; BPSD; antipsychotics; behavioural pharmacology; cognition; dementia; depression