title: [Molecular characterization of osteosarcomas].
abstract: Osteosarcomas are rare with an estimated incidence of 5-6 cases per one million inhabitants per year. As the prognosis has not improved significantly over the last 30 years and more than 30 % of patients still die of the disease a better understanding of the molecular tumorigenesis is urgently needed to identify prognostic and predictive biomarkers as well as potential therapeutic targets. Using genome-wide SNP chip analyses we were able to detect a genetic signature enabling a prognostic prediction of patients already at the time of initial diagnosis. Furthermore, we found the microRNA cluster 17-92 to be constitutively overexpressed in osteosarcomas. The microRNAs included here are intermingled in a complex network of several oncogenes and tumor suppressors that have been described to be deregulated in osteosarcomas. Therefore, the microRNA cluster 17-92 could represent a central regulator in the development of osteosarcomas.
authors.affiliation: Knochentumor-Referenzzentrum am Institut für Pathologie , Universitätsspital Basel, Schönbeinstr. 40, 4031, Basel, Schweiz, daniel.baumhoer@usb.ch.
authors.forename: D
authors.initials: D
authors.lastname: Baumhoer
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D001842:Bone and Bones / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor; D055106:Genome-Wide Association Study; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D060787:Neoplasm Grading; D020411:Oligonucleotide Array Sequence Analysis; D009857:Oncogenes / Q000235:genetics; D012516:Osteosarcoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D062085:RNA, Long Noncoding; D016019:Survival Analysis; D059467:Transcriptome
chemical_list: C568997:MIR17HG, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding