title: Risk factors for the progression of intima-media thickness of carotid arteries: a 2-year follow-up study in patients with newly diagnosed type 2 diabetes.
abstract: BACKGROUND
  Intima-media thickness (IMT) of the carotid arteries is known to have a positive correlation with the risk of cardiovascular disease. This study was designed to identify risk factors affecting the progression of carotid IMT in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Patients with newly diagnosed T2DM with carotid IMT measurements were enrolled, and their clinical data and carotid IMT results at baseline and 2 years later were compared.
  
  
  RESULTS
  Of the 171 patients, 67.2% of males and 50.8% of females had abnormal baseline IMT of the left common carotid artery. At baseline, systolic blood pressure, body mass index and smoking in male participants, and fasting plasma glucose and glycated hemoglobin levels in females were significantly higher in patients with abnormal IMT than in those with normal IMT. Low density lipoprotein cholesterol (LDL-C) levels in males and high density lipoprotein cholesterol (HDL-C) levels in females at the 2-year follow-up were significantly different between the nonprogression and the progression groups. Reduction of the United Kingdom Prospective Diabetes Study (UKPDS) 10-year coronary heart disease (CHD) risk score after 2 years was generally higher in the nonprogression group than the progression group.
  
  
  CONCLUSIONS
  LDL-C levels in males and HDL-C levels in females at the 2-year follow-up were significantly different between participants with and without progression of carotid IMT. Furthermore, a reduction in the UKPDS 10-year CHD risk score appeared to delay the advancement of atherosclerosis. Therefore, the importance of establishing the therapeutic goal of lipid profiles should be emphasized to prevent the progression of carotid IMT in newly diagnosed T2DM patients.
authors.affiliation: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sang Ouk
authors.initials: SO
authors.lastname: Chin
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Hwang
authors.forename: Sang Youl
authors.initials: SY
authors.lastname: Rhee
authors.forename: Suk
authors.initials: S
authors.lastname: Chon
authors.forename: You-Cheol
authors.initials: YC
authors.lastname: Hwang
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Oh
authors.forename: Kyu Jeung
authors.initials: KJ
authors.lastname: Ahn
authors.forename: Ho Yeon
authors.initials: HY
authors.lastname: Chung
authors.forename: Jeong-Taek
authors.initials: JT
authors.lastname: Woo
authors.forename: Sung-Woon
authors.initials: SW
authors.lastname: Kim
authors.forename: Young Seol
authors.initials: YS
authors.lastname: Kim
authors.forename: Ja-Heon
authors.initials: JH
authors.lastname: Kang
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Jeong
keywords: Atherosclerosis; Carotid artery intima-media thickness; Diabetes mellitus type 2; Risk factors