title: Preserve common limb in duodenal-jejunal bypass surgery benefits rats with type 2-like diabetes.
abstract: BACKGROUND
  In order to understand the underlying mechanisms by which weight loss surgeries improve metabolic profiles in type 2 diabetes mellitus (T2DM) patients and to evaluate the relevance of the length of the common limb in modulating various aspects of metabolism, we performed regular duodenal-jejunal bypass (DJB) and long-limb DJB (LL-DJB) surgeries in Goto-Kakizaki (GK) rats and compared their effects on glycemic control.
  
  
  METHODS
  Male GK rats at 12 weeks of age were used for this study. Body weight, food intake, fasting glucose, glucagon-like peptide-1 (GLP-1) level, glucose tolerance, insulin sensitivity, cholesterol and triglycerides levels, and fecal energy content were monitored for 26 weeks after the two types of surgeries.
  
  
  RESULTS
  We performed systematic analyses on GK rats after DJB or long-limb surgeries. Both procedures prevented body weight gain, reduced blood glucose and lipid levels, increased GLP-1 levels, and led to better insulin sensitivity. In general, LL-DJB displayed better effects than DJB, except that both surgeries caused similar increase in GLP-1 levels.
  
  
  CONCLUSIONS
  Both DJB and LL-DJB surgeries triggered beneficial effects in GK rats. LL-DJB showed better outcomes than DJB, which may be due to reduced food intake and higher fecal energy content. This indicates that the length of the common limb could influence metabolic profiles of surgery recipients.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, People's Republic of China, shiyun.1983@aliyun.com.
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Zhang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Sun
authors.forename: Jian-Bao
authors.initials: JB
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Nan-Zheng
authors.initials: NZ
authors.lastname: Chen
authors.forename: Sai
authors.initials: S
authors.lastname: He
authors.forename: Xiong-Wei
authors.initials: XW
authors.lastname: Huo
authors.forename: Wanli
authors.initials: W
authors.lastname: Smith
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005947:Glucose; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D007583:Jejunum / Q000601:surgery*; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D052216:Glucagon-Like Peptide 1; D005947:Glucose