title: Honeycomb membranes prepared from 3-O-amino acid functionalized cellulose derivatives.
abstract: The development of value-added wood-derived polymer products is of significant importance. Of particular interest is the synthesis of advanced bioactive cellulosic materials. In the present research, novel cellulosic honeycomb films are reported. Cellulose was reacted with dimethylthexylsilyl chloride to form regioselective 2,6-di-O-thexyldimethylsilyl cellulose followed by substitution of the C3 with functionalized poly(ethylene glycol) (PEG). The free end of the PEG side chains of the regioselective 3-O-poly(ethylene glycol)-2,6-di-O-thexyldimethylsilyl cellulose served as an attachment point for bioactive molecules. As an example, Fmoc-Gly-OH was linked to the free end of PEG to produce 3-O-Fmoc-Gly-poly(ethylene glycol)-2,6-di-O-thexyldimethylsilyl cellulose. Honeycomb films were produced through film casting under a humid airflow. AFM analysis revealed the directed self-assembly of the 3-O-Fmoc-Gly-poly(ethylene glycol)-2,6-di-O-thexyldimethylsilyl cellulose wherein the pendent 3-O-Fmoc-Gly-poly(ethylene glycol) groups allocated preferentially around the edges of the honeycomb pores.
authors.affiliation: Advanced Biomaterials Chemistry Laboratory, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
authors.forename: William Z
authors.initials: WZ
authors.lastname: Xu
authors.forename: Batia Ben-Aroya
authors.initials: BB
authors.lastname: Bar-Nir
authors.forename: John F
authors.initials: JF
authors.lastname: Kadla
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D008567:Membranes, Artificial; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000596:Amino Acids; D008567:Membranes, Artificial; D011092:Polyethylene Glycols; D002482:Cellulose
keywords: 3-O-Poly(ethylene glycol)–2,6-di-O-thexyldimethylsilyl cellulose; Cellulose; Honeycomb; Poly(ethylene glycol); Regioselective