title: [Skin cancers infiltrating the skull base].
abstract: Squamous cell and basocellular carcinoma of the face have an excellent prognosis. Nevertherless, a small proportion therefore of these cancers differs by a much more aggressive behavior, caracterised by a tendency to infiltrate the deep facial soft tissues and facial bones. The invasion of the craniofacial skeleton and the intracranial structures follows the embryonic fusion lines or the facial sensitive or motor nerves, sometimes years after the initial treatment. The development of craniofacial surgery, reconstruction techniques and conformational radiotherapy allows us now to offer curative guided treatments, for these advanced staged tumors with a remaining limited prognosis. A therapeutic benefit implies a rigorous selection of these patients.
authors.affiliation: Service d'ORL et de chirurgie cervico-faciale, CHUV, 1011 Lausanne. philippe.pasche@chuv.ch
authors.forename: P
authors.initials: P
authors.lastname: Pasche
authors.forename: M
authors.initials: M
authors.lastname: Broome
authors.forename: R T
authors.initials: RT
authors.lastname: Daniel
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011859:Radiography; D019651:Plastic Surgery Procedures / Q000379:methods; D012878:Skin Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D013514:Surgical Procedures, Operative / Q000379:methods