title: Extending the record of bis-γ-pyrone polypropionates from marine pulmonate mollusks.
abstract: The isolation and structure elucidation of 10 unreported polypropionate metabolites (compounds 6-15), structurally related to either ilikonapyrone (1) or onchidione (3), from two onchidiid pulmonate mollusk species are discussed. Structure elucidation was achieved by NMR spectroscopy and chemical correlation with model compounds. Evaluation of in vitro growth-inhibitory properties in human cancer cells was also carried out on some of the isolated polypropionates including previously reported onchidione metabolites.
authors.affiliation: Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB) , Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Carbone
authors.forename: M Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Wang
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cirillo
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011422:Propionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D011422:Propionates; D011753:Pyrones; C586131:ilikonapyrone; C586130:onchidione