title: Application of hexafluoroacetone as protecting and activating reagent in amino acid and peptide chemistry.
abstract: Using hexafluoroacetone as protecting and activating reagent, multifunctional amino acids like aspartic acid can be functionalized regioselectively. This strategy offers i.a. a two-step synthesis for aspartame and preparatively simple access to multifunctional natural and unnatural amino acids, like 4-oxo-L-amino acids, 5-diazo-4-oxo-L-amino acids, 4-substituted L-proline derivatives and various heterocyclic L-amino acids. On application of this strategy to amino diacetic acid N-substituted glycines become readily available.
authors.affiliation: Organisch-Chemisches Institut der Universität Leipzig, Talstrasse 35, D-04103, Leipzig, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Burger
authors.forename: M
authors.initials: M
authors.lastname: Rudolph
authors.forename: S
authors.initials: S
authors.lastname: Fehn
authors.forename: A
authors.initials: A
authors.lastname: Worku
authors.forename: A
authors.initials: A
authors.lastname: Golubev