title: A 1:2 cocrystal of genistein with isonicotinamide: crystal structure and Hirshfeld surface analysis.
abstract: Genistein, a naturally occurring polyphenolic compound, was combined with isonicotinamide, a pharmaceutically acceptable coformer, to yield a 1:2 cocrystal [systematic name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one-pyridine-4-carboxamide (1/2)], C15H10O5·2C6H6N2O. The molecules in the cocrystalline phase are present in their neutral forms, and assemble a molecular layer by means of hydrogen bonding.
authors.affiliation: Department of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Sowa
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Slepokura
authors.forename: Ewa
authors.initials: E
authors.lastname: Matczak-Jon
mesh_terms: D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009536:Niacinamide / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*
chemical_list: D059808:Polyphenols; D009536:Niacinamide; C027681:isonicotinamide
keywords: Hirshfeld surface analysis; active pharmaceutical ingredients; cocrystals; crystal structure; flavonoids; genistein