title: Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
abstract: Fat-specific protein 27 gene (FSP27), isolated by screening for genes specifically expressed in fully differentiated mouse adipocytes, belongs to the cell death-inducing DNA fragmentation factor, alpha subunit-like effector family. FSP27 is induced in not only adipose tissue but also the liver of ob/ob mice, and it promotes the development of fatty liver. The FSP27 gene is expressed in a fatty liver-specific manner and is not detected in the normal mouse liver. FSP27 expression is directly regulated by the induction of the hepatic peroxisome proliferator-activated receptor γ (PPARγ) in ob/ob fatty liver. In the present study, expression of hepatic FSP27 mRNA was determined in non-genetic fatty liver models. The FSP27 gene was markedly induced in the high-fat- or methionine- and choline-deficient (MCD) diet-induced fatty liver, but it was not elevated in alcohol-induced fatty liver. Interestingly, the induction of FSP27 mRNA due to the MCD diet was independent of PPARγ levels and completely absent in the liver from PPARγ-null mice. These results suggest that FSP27 mRNA expression in the liver depends on the etiology of fatty liver.
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aibara
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Matsusue
authors.forename: Kohei
authors.initials: K
authors.lastname: Matsuo
authors.forename: Soichi
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamano
mesh_terms: D000818:Animals; D002796:Choline Deficiency; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism; D004032:Diet; D059305:Diet, High-Fat; D005234:Fatty Liver / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism; D008715:Methionine / Q000172:deficiency; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D047495:PPAR gamma; D011506:Proteins; D012333:RNA, Messenger; C525805:fat-specific protein 27, mouse; D008715:Methionine