title: [Treatment of hypertriglyceridemia with omega-3 fatty acids].
abstract: Omega-3 fatty acids such as eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) have important biologic functions, including effects on membranes, eicosanoid metabolism, and gene transcription. Studies indicate that the use of EPA and DHA lowered triglyceride levels, which is accomplished by decreasing the production of hepatic triglycerides and increasing the clearance of plasma triglycerides. Recent clinical studies showed that intake of omega-3 fatty acids reduced cardiovascular events. In addition, combination therapy with omega-3 fatty acids and a statin is a safe and effective way to improve lipid levels and cardiovascular prognosis beyond the benefits provided by statin therapy alone. Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
authors.forename: Toru
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D002986:Clinical Trials as Topic; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D015525:Fatty Acids, Omega-3; D014280:Triglycerides