title: Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis.
abstract: The therapeutic effect of corilagin (1) was evaluated in an acute colitis model induced by dextran sulfate sodium (DSS) in mice, and the mechanism of action was investigated in this study. Animals were challenged with 2% DSS drinking water for 5 consecutive days and then intraperitoneally treated with 1 (7.5, 15, and 30 mg/kg) daily for 7 days. It was found that 1 significantly decreased the disease activity index, inhibited the shortening of colon length, reduced colon tissue damage, and suppressed myeloperoxidase activity. Moreover, 1 greatly suppressed the secretion of TNF-α, IL-6, and IL-1β, inhibited the degradation of IκB α, and down-regulated expression of cleaved caspase-3 and cleaved caspase-9 in colon tissues of DSS-treated mice. These findings demonstrated that 1 exerts a protective effect on DSS-induced colitis, and its underlying mechanisms are associated with inhibition of the NF-κB pathway that mitigates colon inflammatory responses and apoptosis of intestinal epithelial cells.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University , Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Xiao
authors.forename: Cheng-Yuan
authors.initials: CY
authors.lastname: Lin
authors.forename: Derek H H
authors.initials: DH
authors.lastname: Ho
authors.forename: Jiao
authors.initials: J
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Siu-Wai
authors.initials: SW
authors.lastname: Tsang
authors.forename: Michael
authors.initials: M
authors.lastname: Wong
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhao-Xiang
authors.initials: ZX
authors.lastname: Bian
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy; D003093:Colitis, Ulcerative / Q000139:chemically induced*; D003106:Colon / Q000201:enzymology / Q000378:metabolism; D016264:Dextran Sulfate / Q000009:adverse effects*; D060766:Drinking Water / Q000737:chemistry; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D019410:Interleukin-16 / Q000037:antagonists & inhibitors / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000494:pharmacology
chemical_list: D060766:Drinking Water; D005960:Glucosides; D047348:Hydrolyzable Tannins; D019410:Interleukin-16; D053583:Interleukin-1beta; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C049096:corilagin; D016264:Dextran Sulfate; D009195:Peroxidase; D053148:Caspase 3; D053453:Caspase 9