title: Heteroleptic titanium(IV) catecholato/piperazine systems and their anti-cancer properties.
abstract: In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. mj205@bath.ac.uk.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Hancock
authors.forename: Rachel
authors.initials: R
authors.lastname: Gati
authors.forename: Mary F
authors.initials: MF
authors.lastname: Mahon
authors.forename: Edit Y
authors.initials: EY
authors.lastname: Tshuva
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Jones
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002396:Catechols; D056831:Coordination Complexes; D010879:Piperazines; D000077489:Piperazine; D014025:Titanium