title: Plasma membrane guanylate cyclase is a multimodule transduction system.
abstract: This minireview highlights the studies which suggest that guanylate cyclase is a single-component transducing system, containing distinct signaling modules in a single membrane-spanning protein. A guanylate cyclase signaling model is proposed which envisions the following sequential events: (1) a signal is initiated by the binding of the hormone to the ligand binding module; (2) the signal is potentiated by ATP at ARM; and (3) the amplified signal is finally transduced at the catalytic site. All of these signaling steps together constitute a switch, which when turned on, generates the second messenger cyclic GMP.
authors.affiliation: The Unit of Regulatory and Molecular Biology, Pennsylvania College of Optometry, 1200 West Godfrey Avenue, 19141, Philadelphia, Pennsylvania, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Sharma
authors.forename: T
authors.initials: T
authors.lastname: Duda
authors.forename: A
authors.initials: A
authors.lastname: Sitaramayya