title: Neoadjuvant chemotherapy or chemoradiotherapy for locally advanced esophageal cancer.
abstract: In patients with operable esophageal cancer, there is evidence supporting the use of preoperative chemotherapy or preoperative chemoradiation. The addition of radiotherapy to chemotherapy seems more relevant for the more locally advanced cancers. There is a need to examine in trials more modern chemotherapy combinations with and without concurrent radiation and for research into assessing methods for predicting outcomes from neoadjuvant therapy as part of the paradigm of therapy for this disease.
authors.affiliation: Upper GI, Soft Tissue Unit, Discipline of Surgery, Princess Alexandra Hospital, The University of Queensland, Ipswich Road, Buranda, Brisbane 4102, Australia. Electronic address: m.smithers@uq.edu.au.
authors.forename: B Mark
authors.initials: BM
authors.lastname: Smithers
authors.forename: Iain
authors.initials: I
authors.lastname: Thomson
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D002986:Clinical Trials as Topic; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D016629:Esophagectomy; D006801:Humans; D020360:Neoadjuvant Therapy; D011379:Prognosis
keywords: Esophageal cancer; Esophagectomy; Esophagogastric junction adenocarcinoma; Neoadjuvant chemoradiation; Neoadjuvant chemotherapy; Pathologic complete response