title: Caloric restriction and aging stem cells: the stick and the carrot?
abstract: Adult tissue stem cells have the ability to adjust to environmental changes and affect also the proliferation of neighboring cells, with important consequences on tissue maintenance and regeneration. Stem cell renewal and proliferation is strongly regulated during aging of the organism. Caloric restriction is the most powerful anti-aging strategy conserved throughout evolution in the animal kingdom. Recent studies relate the properties of caloric restriction to its ability in reprogramming stem-like cell states and in prolonging the capacity of stem cells to self-renew, proliferate, differentiate, and replace cells in several adult tissues. However this general paradigm presents with exceptions. The scope of this review is to highlight how caloric restriction impacts on diverse stem cell compartments and, by doing so, might differentially delay aging in the tissues of lower and higher organisms.
authors.affiliation: Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, FG, Italy. Electronic address: g.mazzoccoli@operapadrepio.it.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli
authors.affiliation: Genomics and Bioinformatics Centre, Major University of Santiago, Santiago, Chile.
authors.forename: Maria Florencia
authors.initials: MF
authors.lastname: Tevy
authors.affiliation: Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, FG, Italy; University College London, Institute for Liver and Digestive Health, Division of Medicine, Royal Free Campus, London, United Kingdom.
authors.forename: Michela
authors.initials: M
authors.lastname: Borghesan
authors.affiliation: Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, FG, Italy.
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Delle Vergini
authors.affiliation: Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, FG, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; University College London, Institute for Liver and Digestive Health, Division of Medicine, Royal Free Campus, London, United Kingdom. Electronic address: m.vinciguerra@ucl.ac.uk.
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D001343:Autophagy / Q000502:physiology; D031204:Caloric Restriction; D016922:Cellular Senescence / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D012038:Regeneration / Q000502:physiology; D056564:Sirtuin 1 / Q000502:physiology
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Aging; Caloric restriction; Cell renewal; Regeneration; Stem cells