title: Extended high frequency audiometry in polycystic ovary syndrome.
abstract: OBJECTIVE
  Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 5-10% of women in reproductive age. Insulin resistance, dyslipidemia, glucose intolerance, hypertension, and obesity are metabolic disorders accompanying the syndrome. PCOS is a chronic proinflammatory state and the disease is associated with endothelial dysfunction. In diseases with endothelial damage, hearing in high frequencies are mostly effected in early stages. We evaluated extended high frequency hearing loss in PCOS patients.
  
  
  METHODS
  Forty women diagnosed as PCOS and 25 healthy controls were included in this study. Age and BMI of PCOS and control groups were comparable. Each subject was tested with low (250-2000 Hz), high (4000-8000 Hz), and extended high frequency audiometry (8000-20000). Hormonal and biochemical values including LH, LH/FSH, testosterone, fasting glucose, fasting insulin, HOMA-I, and CRP were calculated.
  
  
  RESULTS
  PCOS patients showed high levels of LH, LH/FSH, testosterone, fasting insulin, glucose, HOMA-I, and CRP levels. The hearing thresholds of the groups were similar at frequencies of 250, 500, 1000, 2000, and 4000 Hz; statistically significant difference was observed in 8000-14000 Hz in PCOS group compared to control group.
  
  
  CONCLUSIONS
  PCOS patients have hearing impairment especially in extended high frequencies. Further studies are needed to help elucidate the mechanism behind hearing impairment in association with PCOS.
authors.affiliation: Medical School, Evliya Celebi Training and Research Hospital, Department of Otolaryngology, Dumlupinar University, Okmeydani Street, 43340 Kutahya, Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kucur
authors.forename: Suna Kabil
authors.initials: SK
authors.lastname: Kucur
authors.forename: Ilay
authors.initials: I
authors.lastname: Gozukara
authors.forename: Ali
authors.initials: A
authors.lastname: Seven
authors.forename: Kadriye Beril
authors.initials: KB
authors.lastname: Yuksel
authors.forename: Nadi
authors.initials: N
authors.lastname: Keskin
authors.forename: Fatih
authors.initials: F
authors.lastname: Oghan
mesh_terms: D000328:Adult; D001299:Audiometry / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D006316:Hearing Loss, High-Frequency / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D002097:C-Reactive Protein