title: Memory recall and modifications by activating neurons with elevated CREB.
abstract: Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the expression of those memories. However, it is unknown whether artificially activating just these selected neurons in the absence of behavioral cues is sufficient to recall that fear memory. Using an ectopic rat vanilloid receptor TRPV1 and capsaicin system, we found that activating this specific ensemble of neurons was sufficient to recall established fear memory. Furthermore, this neuronal activation induced a reconsolidation-like reorganization process, or strengthening of the fear memory. Thus, our findings establish a direct link between the activation of specific ensemble of neurons in the lateral amygdala and the recall of fear memory and its subsequent modifications.
authors.affiliation: 1] Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea. [2].
authors.forename: Jieun
authors.initials: J
authors.lastname: Kim
authors.affiliation: 1] Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea. [2].
authors.forename: Jeong-Tae
authors.initials: JT
authors.lastname: Kwon
authors.affiliation: Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea.
authors.forename: Hyung-Su
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Sheena A
authors.identifier: 000000015451489X
authors.initials: SA
authors.lastname: Josselyn
authors.affiliation: Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Han
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000200:Action Potentials / Q000187:drug effects / Q000235:genetics; D000679:Amygdala / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000187:drug effects; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000235:genetics; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000502:physiology*; D010766:Phosphorylation / Q000187:drug effects / Q000235:genetics; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D018091:Receptors, AMPA / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism; D014161:Transduction, Genetic
chemical_list: D000841:Anisomycin; D050882:CREB-Binding Protein; D002211:Capsaicin; D049452:Green Fluorescent Proteins; D011500:Protein Synthesis Inhibitors; D018091:Receptors, AMPA; D012694:Serine; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse