title: Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn.
abstract: Five ursane type sulfated saponins have been isolated from the aerial parts of Zygophyllum fabago Linn. (locally called Chashum). The urease inhibitory effects of these compounds have been investigated for the first time as well as their molecular docking studies have also been carried out to check the structure-activity relationship. The IC50 values of these compounds could not be found due to paucity of the samples. The molecular docking studies were performed only for the most active compound mono sodium salt of 3β,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-[β-D-glucopyranosyl] ester (Zygofaboside A; 1).
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: saleha_iccs@yahoo.com.
authors.forename: Saleha Suleman
authors.initials: SS
authors.lastname: Khan
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.affiliation: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: afsarhej@yahoo.com.
authors.forename: Afsar
authors.initials: A
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Wadood
authors.affiliation: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Umar
authors.initials: U
authors.lastname: Farooq
authors.affiliation: Pharmaceutical Division, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan.
authors.forename: Amir
authors.initials: A
authors.lastname: Ahmed
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Aqib
authors.initials: A
authors.lastname: Zahoor
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: vuahmad@hotmail.com.
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Sener
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.
authors.forename: Nurgun
authors.initials: N
authors.lastname: Erdemoglu
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D062105:Molecular Docking Simulation; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors*; D032445:Zygophyllum / Q000737:chemistry*
chemical_list: C000593041:3,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-glucopyranosyl ester; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D012503:Saponins; D014510:Urease
keywords: Molecular docking; Sulfated saponins; Urease inhibitory activity; Ursane; Zygophyllum fabago