title: [Lymphatics and lung transplantation. A review].
abstract: The role of lymph circulation in lung transplantation (LTx) has not really been studied since the first animal models, which allowed the development of solid organ transplantations. However, the oedema observed in the grafts immediately after LTx often remains unpredictable and unexplained. Although it is an integral part of the entity called "primary graft failure". Despite its multifactor aspects making the interpretation difficult, the possibility of a change in the lymph circulation is proposed to explain an oedema occurrence. The animal models focusing on this point were mainly developed in small bowel transplantation because of interesting similarities with LTx. The analysed criteria were the consequences of lymphatic vessels interruption as well as their regeneration modalities after LTx. These studies also analysed the role of lymphatic vessels in the rejection induction, the local immune response and the occurrence of obliterative bronchiolitis. This review allowed analysing the studies, which approached the lymphatic vessel issue in transplantation.
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France. Electronic address: francoise.lepimpec-barthes@egp.aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Le Pimpec-Barthes
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: P
authors.initials: P
authors.lastname: Mordant
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: C
authors.initials: C
authors.lastname: Pricopi
authors.affiliation: Service de d'anatomie pathologique, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: L
authors.initials: L
authors.lastname: Gibaud
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Arame
authors.affiliation: Service de d'anatomie pathologique, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Cazes
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Badia
authors.affiliation: Service de radiologie, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Hernigou
authors.affiliation: Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: M
authors.initials: M
authors.lastname: Riquet
mesh_terms: D001989:Bronchiolitis Obliterans / Q000209:etiology; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D016040:Lung Transplantation; D042601:Lymphatic Vessels / Q000502:physiology; D055031:Primary Graft Dysfunction / Q000209:etiology*; D012038:Regeneration
keywords: Animal models; Défaillance primaire du greffon; Lung transplantation; Lymphatic vessels; Modèles animaux; Primary graft dysfunction; Pulmonary oedema; Transplantation pulmonaire; Vaisseaux lymphatiques; Œdème pulmonaire