title: Is diabetes mellitus a negative prognostic factor for the treatment of advanced non-small-cell lung cancer?
abstract: BACKGROUND
  It has been demonstrated that there are a lot of different prognostic factors which are worthy of consideration whereas diabetes mellitus (DM) has not been clearly or consistently identified as a prognostic value in advanced non-small cell lung cancer (NSCLC). The aim of this study was to investigate the prognostic significance of the characteristics of patients in advanced NSCLC. Specifically, we investigated the impact of DM for progression-free survival (PFS) and overall survival (OS) in patients receiving first-line platinum-based doublets chemotherapy.
  
  
  METHODS
  We retrospectively reviewed 442 patients with advanced NSCLC. DM and other potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival.
  
  
  RESULTS
  The results of univariate analysis for OS were identified as having prognostic significance: performance status (p<0.001), stage (p<0.001), DM (p<0.001), liver metastasis (p=0.02) and brain metastasis (p<0.001). Stage, diabetes mellitus, and liver metastasis were identified as having prognostic significance for PFS. Multivariate analysis showed that poor performance status, presence of DM and advanced stage were considered independent negative prognostic factors for OS (p 0.001, p<0.001 and p<0.001 respectively). Furthermore, DM and stage were considered independent negative prognostic factors for PFS (p 0.005 and p 0.001 respectively).
  
  
  CONCLUSIONS
  In conclusion, DM at the time of diagnosis was associated with the negative prognostic importance for PFS and OS in the advanced stage patients who were receiving first-line platinum-based doublets chemotherapy. In addition poor performance status and advanced stage were identified as negative prognostic factors.
authors.affiliation: Dicle University, Department of Medical Oncology, Diyarbakir, Turkey. Electronic address: dr.ainal@gmail.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Inal
authors.affiliation: Dicle University, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: M Ali
authors.initials: MA
authors.lastname: Kaplan
authors.affiliation: Dicle University, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kucukoner
authors.affiliation: Dicle University, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Zuhat
authors.initials: Z
authors.lastname: Urakcı
authors.affiliation: Dicle University, Division of Endocrinology, Diyarbakir, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Kılınc
authors.affiliation: Dicle University, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isıkdogan
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D048909:Diabetes Complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D003920:Diabetes Mellitus; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Carcinoma pulmonar de células não pequenas; Diabetes mellitus; Factores de prognóstico; Non-small cell lung cancer; Prognostic factors