title: Antidiabetic potential of the heme oxygenase-1 inducer curcumin analogues.
abstract: Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of diabetes, agents and cellular molecules that can modulate these stress responses are emerging as potential targets for intervention and treatment of diabetic diseases. It has been recognized that heme oxygenase-1 (HO-1) plays an important role in cellular protection. Because HO-1 can reduce oxidative stress, inflammatory stress, and ER stress, in part by exerting antioxidant, anti-inflammatory, and antiapoptotic effects, HO-1 has been suggested to play important roles in pathogenesis of diabetes. In the present review, we will explore our current understanding of the protective mechanisms of HO-1 in diabetes and present some emerging therapeutic options for HO-1 expression in treating diabetic diseases, together with the therapeutic potential of curcumin analogues that have their ability to induce HO-1 expression.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 460 Iksandae-ro, Iksan 570-749, Republic of Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Son
authors.forename: Ju Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Yong-Kwan
authors.initials: YK
authors.lastname: Cheong
authors.forename: Hun-Taeg
authors.initials: HT
authors.lastname: Chung
authors.forename: Hyun-Ock
authors.initials: HO
authors.lastname: Pae
mesh_terms: D000818:Animals; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D004790:Enzyme Induction / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000096:biosynthesis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000378:metabolism; D018384:Oxidative Stress
chemical_list: D007004:Hypoglycemic Agents; D018836:Inflammation Mediators; D051547:Heme Oxygenase-1; D003474:Curcumin