title: Change in refractive index of muscle tissue during laser-induced interstitial thermotherapy.
abstract: This paper presents a long-period fiber-grating (LPG) based Michelson interferometric refractometry to monitor the change in refractive index of porcine muscle during laser-induced interstitial thermotherapy (LITT). As the wavelength of RI interferometer alters with the change in refractive index around the probe, the LPG based refractometry is combined with LITT system to measure the change in refractive index of porcine muscle when irradiated by laser. The experimental results show the denaturation of tissue alters the refractive index significantly and the LPG sensor can be applied to monitor the tissue state during the LITT.
authors.affiliation: Key Lab of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China.
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Meimei
authors.initials: M
authors.lastname: Chen
authors.forename: Shupeng
authors.initials: S
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.forename: Zhenyi
authors.initials: Z
authors.lastname: Chen
authors.forename: Tingyun
authors.initials: T
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D000818:Animals; D006979:Hyperthermia, Induced; D007368:Interferometry; D007834:Lasers; D018482:Muscle, Skeletal / Q000473:pathology*; D012031:Refractometry; D013552:Swine; D013696:Temperature
keywords: Michelson interferometer; Refractive index; laser-induced interstitial thermotherapy; long-period fiber grating