title: [Focus on mediastinal Castleman disease].
abstract: Castleman disease is a rare lymph nodes disease whose name covers different clinical presentations. The most frequent histology is the hyaline vascular localized form. In this case, Castleman disease occurs in young adults, and is localized to the mediastinum in one third of the cases. The disease is often asymptomatic, but paraneoplasic pemphigus has been described. The management of this form of Castleman disease is based on complete surgical resection. Perioperative immunomodulating treatments may be discussed in case of paraneoplasic pemphigus, mostly when affecting the bronchial tree.
authors.affiliation: Service de pneumologie A, centre de compétences maladies rares pulmonaires, hôpital Bichat, AP-HP, 16, rue Henri-Huchard, 75877 Paris cedex 18, France. Electronic address: raphael.borie@bch.aphp.fr.
authors.forename: R
authors.initials: R
authors.lastname: Borie
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, AP-HP, 75908 Paris cedex 15, France.
authors.forename: M
authors.initials: M
authors.lastname: Riquet
authors.affiliation: Département de pathologie, hôpital Bichat, AP-HP, 75877 Paris cedex 18, France.
authors.forename: C
authors.initials: C
authors.lastname: Danel
authors.affiliation: Service de pneumologie A, centre de compétences maladies rares pulmonaires, hôpital Bichat, AP-HP, 16, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: B
authors.initials: B
authors.lastname: Crestani
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, AP-HP, 75908 Paris cedex 15, France.
authors.forename: P
authors.initials: P
authors.lastname: Mordant
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy
keywords: Bronchiolite; Bronchiolitis; Castleman disease; Immunoglobulin; Immunoglobuline; Paraneoplasic pemphigus; Pemphigus paranéoplasique; Rituximab; Transplantation