title: The off-label use of the Amplatzer muscular VSD occluder for large patent ductus arteriosus: a case report and review.
abstract: A percutaneous approach to the closure of patent ductus arteriosus (PDA) is the preferred procedure in the majority of cases. However, there is little experience with percutaneous closure of unusually large PDA. We report the case of a 28-year-old female with moderate left ventricular dilation and pulmonary hypertension resulting from a large 16 mm PDA. Percutaneous closure was successfully performed using an off-label Amplatzer muscular ventricular septal defect occluder after intravascular ultrasound assessment. Technical challenges, including accurate assessment of defect size and device selection are exemplified along with a comprehensive overview of the available literature.
authors.affiliation: Aventura Hospital and Medical Center, Miami, FL, USA.
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Cubeddu
authors.forename: Ivan
authors.initials: I
authors.lastname: Babin
authors.forename: Ignacio
authors.initials: I
authors.lastname: Inglessis
mesh_terms: D000328:Adult; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D056687:Off-Label Use; D055989:Septal Occluder Device; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional