title: Surgical management of prostate cancer.
abstract: Surgery remains a mainstay in the management of localized prostate cancer. This article addresses surgical aspects germane to the management of men with prostate cancer, including patient selection for surgery, nerve-sparing approaches, minimization of positive surgical margins, and indications for pelvic lymph node dissection. Outcomes for men with high-risk prostate cancer following surgery are reviewed, and the present role of neoadjuvant therapy before radical prostatectomy is discussed. In addition, there is a review of the published literature on surgical ablative therapies for prostate cancer.
authors.affiliation: Department of Urology, University of Washington School of Medicine, 1959 Northeast Pacific, Seattle, WA 98195, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Wright
authors.forename: Jason P
authors.initials: JP
authors.lastname: Izard
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Lin
mesh_terms: D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010388:Pelvis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D013521:Urologic Surgical Procedures, Male / Q000379:methods
keywords: Cryotherapy; High-intensity focused ultrasound; Neoadjuvant therapy; Nerve sparing; Pelvic lymph node dissection; Prostate cancer; Radical prostatectomy; Surgical margin