title: Violapyrones A-G, α-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces.
abstract: Seven new 3,4,6-trisubstituted α-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 μg/mL.
authors.affiliation: Laboratory of Metabolic Disease Research and Drug Development, China Medical University , Shenyang 110001, People's Republic of China.
authors.forename: Jiaoyue
authors.initials: J
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yanru
authors.initials: Y
authors.lastname: Cao
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Zheng
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Chenglin
authors.initials: C
authors.lastname: Jiang
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000235:genetics; D005243:Feces / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006922:Hylobates / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011753:Pyrones