title: Prevalence of coeliac disease in patients with non-alcoholic fatty liver disease.
abstract: OBJECTIVE
  Coeliac disease (CD) may be associated with several liver disorders including primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis. Furthermore preliminary data suggest a causative role of CD in steatosis and steatohepatitis. The aim of present study was to determine the prevalence of CD in a series of patients with non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  In a cross sectional study (2008-2010), 403 consecutive NAFLD patients (127 female and 276 male) referred to GI clinics of the Zahedan University of Medical Sciences were included. IgA anti-tissue transglutaminase (Anti-tTG) was used for screening of coeliac disease. In the patients with a positive serologic test, duodenal biopsies were taken to confirm the diagnosis.
  
  
  RESULTS
  The mean±SD of the age and BMI of patients were 37.4±12.4years and 28.3±4.15kg/m(2) respectively. BMIs lower than 25kg/m(2) were found in 58 subjects (14.5%). Furthermore diabetes mellitus and hyperlipidaemia were diagnosed in 48 (11.9%) and 84 (20.8%) individuals respectively. Positive Anti-tTGs were found in 14/403 (3.4%) and 13/403 (3.2%, 95% CI 1.5-4.9) had coeliac disease according to the modified Marsh classification; 8 had type I, 3 type II, 1 type IIIA and 1 type IIIB lesions.
  
  
  CONCLUSIONS
  According to our data, prevalence of CD in the subjects with NAFLD is higher than the rates reported in the general population. Therefore screening for CD in selected cases of NAFLD may be appropriate.
authors.affiliation: Department of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Bakhshipour
authors.forename: Mahmoud Ali
authors.initials: MA
authors.lastname: Kaykhaei
authors.forename: Nezarali
authors.initials: N
authors.lastname: Moulaei
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mashhadi
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D019204:GTP-Binding Proteins; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D007070:Immunoglobulin A / Q000097:blood; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D015995:Prevalence; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: Anti-tissue transglutaminase; Coeliac disease; Liver function tests; Non-alcoholic fatty liver disease