title: Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development.
abstract: An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.
authors.affiliation: Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
authors.forename: Franziska
authors.initials: F
authors.lastname: Baenke
authors.forename: Barrie
authors.initials: B
authors.lastname: Peck
authors.forename: Heike
authors.initials: H
authors.lastname: Miess
authors.forename: Almut
authors.initials: A
authors.lastname: Schulze
mesh_terms: D001343:Autophagy; D015687:Cell Hypoxia; D002465:Cell Movement; D006801:Humans; D008055:Lipids / Q000096:biosynthesis*; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D011499:Protein Processing, Post-Translational; D059016:Tumor Microenvironment
chemical_list: D008055:Lipids