title: Lack of positive effect of intravitreal bevacizumab in central serous chorioretinopathy: meta-analysis and review.
abstract: OBJECTIVE
  To review and evaluate the effects of intravitreal bevacizumab injection (IVB) in centralserous chorioretinopathy (CSC) by meta-analysis.
  
  
  METHODS
  Clinical controlled studies that evaluated the effect of IVB in CSC were identified through systematic searches of Embase, PubMed, and the Cochrane Central Register of Controlled Trials. Data on the best-corrected visual acuity (BCVA) in logMAR and central macular thickness (CMT) in μm at baseline and 6 months after IVB were extracted and compared with those treated by simple observation.
  
  
  RESULTS
  Four clinical controlled studies were included in the meta-analysis. The IVB injection group achieved better BCVA at a follow-up of 6 months. However, the analysis showed that there were no significant differences of BCVA at 6 months after injection between IVB group and the observation group (-0.02 logMAR, 95% CI -0.14 to 0.11, P=0.80). The analysis of the reduction in CMT revealed that the difference between groups was not statistically significant (-8.37 μm, 95% CI -97.26 to 80.52, P=0.85). No report assessed severe complications or side effects of IVB in patients with CSC.
  
  
  CONCLUSIONS
  Meta-analysis failed to verify the positive effect of IVB in CSC based on the epidemiological literature published to date.
authors.affiliation: Department of Ophthalmology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Chung
authors.affiliation: Department of Ophthalmology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: E J
authors.initials: EJ
authors.lastname: Seo
authors.affiliation: Department of Ophthalmology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: H M
authors.initials: HM
authors.lastname: Lew
authors.affiliation: Department of Ophthalmology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000068258:Bevacizumab; D056833:Central Serous Chorioretinopathy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D058449:Intravitreal Injections; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab