title: Radioimmunoassay for carcinoembryonic antigen as an adjunct to liver scan in the detection of liver metastases from digestive-tract cancer.
abstract: In a series of 327 patients with primary GI malignancies, the occurrence of hepatic metastases was correctly detected in 70% of 113 cases by focal defects in the radiocolloid scintiscan. Only 1% of false positives were observed among the 214 patients without hepatic metastases. For these patients, the predictive value of the liver scan was 97%, and the overall accuracy, 89%. A composite test formed by disjoining focal radionuclide defects with the combination of elevated CEA and hepatomegaly, or elevated CEA and high alkaline phosphatase activity, exhibited a predictive value of 92% and an overall accuracy of 92%. Formation of such a composite test may be useful for preserving high accuracy when very strict scintigraphic criteria for metastases are employed.
authors.affiliation: Dept. of Nuclear Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aburano
authors.forename: N
authors.initials: N
authors.lastname: Tonami
authors.forename: K
authors.initials: K
authors.lastname: Hisada
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood*; D004067:Digestive System Neoplasms / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D011863:Radioimmunoassay; D011877:Radionuclide Imaging
chemical_list: D002272:Carcinoembryonic Antigen