title: FDG-PET, a Complementary Modality to Computed-Tomography in Radiotherapy Target Volume Delineation for Head and Neck Cancer.
abstract: OBJECTIVE
  The objective of the current review was to use published data to assess the role of[18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) as a complementary modality to computed-tomography (CT) in radiotherapy target volume delineation for head and neck cancer (HNC).
  
  
  METHODS
  Studies were identified by searching PubMed electronic databases. Both prospective and retrospective studies were included. Information regarding the role of FDG-PET for radiotherapy target volume delineation for HNC was analyzed.
  
  
  RESULTS
  FDG-PET is a promising tool for improving radiotherapy target volume delineation by defining a metabolically active biological target volume (BTV). The use of novel PET tracers representing properties such as hypoxia, protein synthesis and proliferation remain to be better characterized.
  
  
  CONCLUSIONS
  The role of FDG-PET for radiotherapy target volume delineation for patients with HNC is expanding and should be further evaluated in clinical trials.
authors.affiliation: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, USA.
authors.forename: Voichita
authors.initials: V
authors.lastname: Bar-Ad
authors.forename: Wenyin
authors.initials: W
authors.lastname: Shi
authors.forename: Madalina
authors.initials: M
authors.lastname: Tuluc
authors.forename: Nitin
authors.initials: N
authors.lastname: Ohri
authors.forename: David
authors.initials: D
authors.lastname: Cognetti
authors.forename: Joseph
authors.initials: J
authors.lastname: Curry
authors.forename: Charles
authors.initials: C
authors.lastname: Intenso
keywords: FDG-PET; Head and neck cancer; Radiotherapy target volumes