title: Malignant melanoma of the ileo-anal pouch anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case.
abstract: A 62 year-old patient with therapy-refractory pouchitis after proctocolectomy for ulcerative colitis was admitted with hematochezia and abdominal discomfort. A malignant melanoma (MM) was found after repeated biopsies of the pouch. Complete staging revealed no evidence for distant metastases and the patient underwent abdominoperineal pouch resection. Six weeks later, the patient was readmitted because of severe general deterioration and diffuse metastatic spread to the liver was found. The patient died of hepatorenal syndrome shortly thereafter.Patients with inflammatory bowel disease are at increased risk of developing cancer, including rarities such as MM. Our experience stresses the importance of repeated biopsies in therapy-refractory pouchitis.
authors.affiliation: Department of Surgery, University of Bonn, Sigmund-Freud-Strasse 25, Bonn 53127, Germany. Philipp.Lingohr@ukb.uni-bonn.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Lingohr
authors.forename: Thomas
authors.initials: T
authors.lastname: Galetin
authors.forename: Hanno
authors.initials: H
authors.lastname: Matthaei
authors.forename: Eberhard
authors.initials: E
authors.lastname: Straub
authors.forename: Azin
authors.initials: A
authors.lastname: Jafari
authors.forename: Edwin
authors.initials: E
authors.lastname: Bölke
authors.forename: Jörg C
authors.initials: JC
authors.lastname: Kalff
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Vestweber
mesh_terms: D001003:Anal Canal / Q000473:pathology / Q000601:surgery*; D000714:Anastomosis, Surgical; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches / Q000473:pathology*; D003251:Constriction, Pathologic; D017809:Fatal Outcome; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D019449:Pouchitis / Q000209:etiology / Q000473:pathology; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*