title: Plasma copeptin levels are associated with prognosis of severe acute pancreatitis.
abstract: Copeptin reflects the individual stress level, and is correlated with outcomes of critical illness. This study was designed to evaluate its relationship with disease severity, local complications, organ failure and mortality of severe acute pancreatitis (SAP). Seventy-eight SAP patients and 78 sex- and age-matched healthy individuals were recruited. Plasma samples were obtained on admission from SAP patients and at study entry from healthy individuals. Copeptin concentration was determined using enzyme-linked immunosorbent assay. Plasma copeptin level was obviously higher in patients than in healthy individuals, was identified as an independent predictor of local complications, organ failure and in-hospital mortality, was highly associated with traditional predictors of disease severity and mortality including the Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, sequential organ failure assessment score, and predicted local complications, organ failure, and in-hospital mortality of SAP patients with high areas under receiver operating characteristic curve. Furthermore, its predictive value was similar to the traditional predictors'. However, it could not improve these traditional predictors' predictive values. Therefore, increased plasma copeptin level is associated with disease severity and identified as a novel prognostic marker of local complications, organ failure and mortality after SAP.
authors.affiliation: Department of Paediatrics, Tongde Hospital Zhejiang Chinese Medical University, 234 Gucui Road, Hangzhou 310012, China.
authors.forename: Gao
authors.initials: G
authors.lastname: Sang
authors.affiliation: Department of Paediatrics, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Du
authors.affiliation: Department of Traditional Chinese Internal Medicine, Tongde Hospital Zhejiang Chinese Medical University, 234 Gucui Road, Hangzhou 310012, China. Electronic address: gstongde@63.com.
authors.forename: Yong-Yi
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, Tongde Hospital Zhejiang Chinese Medical University, 234 Gucui Road, Hangzhou 310012, China.
authors.forename: Yang-Bo
authors.initials: YB
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Tongde Hospital Zhejiang Chinese Medical University, 234 Gucui Road, Hangzhou 310012, China.
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Tongde Hospital Zhejiang Chinese Medical University, 234 Gucui Road, Hangzhou 310012, China.
authors.forename: Yong-Can
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000401:mortality / Q000473:pathology; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000097:blood* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index
chemical_list: D006020:Glycopeptides; C048197:copeptins
keywords: Biomarker; Copeptin; Prognosis; Severe acute pancreatitis