title: Simian adenovirus type 35 has a recombinant genome comprising human and simian adenovirus sequences, which predicts its potential emergence as a human respiratory pathogen.
abstract: Emergent human and simian adenoviruses (HAdVs) may arise from genome recombination. Computational analysis of SAdV type 35 reveals a genome comprising a chassis with elements mostly from two simian adenoviruses, SAdV-B21 and -B27, and regions of high sequence similarity shared with HAdV-B21 and HAdV-B16. Although recombination direction cannot be determined, the presence of these regions suggests prior infections of humans by an ancestor of SAdV-B35, and/or vice versa. Absence of this virus in humans may reflect non-optimal conditions for zoonosis or incomplete typing, e.g., limited epitope-based. The presence of both a critical viral replication element found in HAdV genomes and genes that are highly similar to ones in HAdVs suggest the potential to establish in a human host. This allows a prediction that this virus may be a nascent human respiratory pathogen. The recombination potential of human and simian adenovirus genomes should be considered in the use of SAdVs as vectors for gene delivery in humans.
authors.affiliation: Chemistry Department, American University, Washington, D.C. 20016, USA; Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
authors.forename: Shoaleh
authors.initials: S
authors.lastname: Dehghan
authors.forename: Jason
authors.initials: J
authors.lastname: Seto
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
authors.forename: David W
authors.initials: DW
authors.lastname: Dyer
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics; D000261:Adenoviruses, Simian / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D019295:Computational Biology; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D000882:Haplorhini; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017385:Sequence Homology
chemical_list: D004279:DNA, Viral
keywords: Human adenovirus; Recombination; Simian adenovirus; Viral genomics