title: Mechanobiology of low-density lipoprotein transport within an arterial wall--impact of hyperthermia and coupling effects.
abstract: The effects of hyperthermia, coupling attributes and property variations on Low-density lipoprotein (LDL) transport within a multi-layered wall while accounting for the fluid structure interaction (FSI) is analyzed in this work. To understand the potential impact of the hyperthermia process, thermo-induced attributes are incorporated, accounting for the plasma flow, mass transfer, as well as the elastic wall structure. The coupling effect of osmotic pressure, Soret and Dufour diffusion is discussed and their influence on LDL transport is examined, demonstrating that only the Soret effect needs to be accounted for. The effect of thermal expansion on changing the behavior of flow, mass transport, and elastic structure is illustrated and analyzed while incorporating the variations in the effective LDL diffusivity and consumption rate, as well as other dominating parameters. It is shown that hyperthermia results in an enhancement in LDL transport by increasing the concentration levels within the arterial wall.
authors.affiliation: Department of Mechanical Engineering, University of California, Riverside, CA 92521, United States.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chung
authors.affiliation: Department of Mechanical Engineering, University of California, Riverside, CA 92521, United States. Electronic address: vafai@engr.ucr.edu.
authors.forename: Kambiz
authors.initials: K
authors.lastname: Vafai
mesh_terms: D001011:Aorta / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D001692:Biological Transport; D001703:Biophysics; D004058:Diffusion; D004730:Endothelium, Vascular / Q000473:pathology; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008077:Lipoproteins, LDL / Q000502:physiology*; D008955:Models, Cardiovascular; D009995:Osmosis; D009997:Osmotic Pressure; D016062:Porosity
chemical_list: D008077:Lipoproteins, LDL
keywords: FSI; Hyperthermia; Low-density lipoprotein transport; Multi-layered arterial wall; Osmosis; Porous media; Soret and Dufour effect