title: Occupational and non-occupational allergic contact dermatitis: a follow-up study.
abstract: OBJECTIVE
  The aim of this study was to obtain insight into the clinical course and prognosis of allergic contact dermatitis (ACD), including potential effects of genetic and environmental factors.
  
  
  METHODS
  Eighty-two patients with previously defined ACD acquired occupationally (OACD) or non-occupationally (NOACD) were patch retested and evaluated for the presence of persistent eczema, atopy and filaggrin mutations.
  
  
  RESULTS
  The crude risk for the persistence of a positive patch test (PT) reaction was 6.3 times higher (95% CI 3.63-11.0) for PT reactions assessed as '+++' compared to '++' reactions at the first PT. Among the categories of OACD, NOACD, age, gender, atopy, and the number of positive PT reactions at the first and second PT, only OACD (OR 10.0, 95% CI 1.95-51.2) and number of positive PT reactions at retesting (OR 3.85, 95% CI 1.57-9.44) were found to be predictors of persistent eczema.
  
  
  CONCLUSIONS
  Occupationally acquired contact allergy was emphasized as the most important factor in predicting poor prognosis of ACD.
authors.affiliation: Institute for Medical Research and Occupational Health, Zagreb, Croatia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Macan
authors.forename: Davor
authors.initials: D
authors.lastname: Rimac
authors.forename: Sanja
authors.initials: S
authors.lastname: Kežić
authors.forename: Veda Marija
authors.initials: VM
authors.lastname: Varnai
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications; D017449:Dermatitis, Allergic Contact / Q000150:complications / Q000235:genetics / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000150:complications; D009783:Dermatitis, Occupational / Q000150:complications / Q000235:genetics / Q000276:immunology*; D004485:Eczema / Q000150:complications*; D005260:Female; D000091344:Filaggrin Proteins; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010328:Patch Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000150:complications
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins