title: Good clinical outcome after combined endovascular and neurosurgical treatment of cerebral venous sinus thrombosis.
abstract: BACKGROUND
  A subgroup of patients suffering from cerebral venous sinus thrombosis (CVST) has a poor prognosis with standard anticoagulant treatment alone. Over a five-year period, we treated nine patients with aggressive endovascular therapy and neurosurgical/neurointensive treatment. In this study, the effect of this treatment is evaluated.
  
  
  METHODS
  A retrospective analysis of electronic patient files and data was performed.
  
  
  RESULTS
  All treated patients had partial or complete recanalization of the affected sinus after endovascular treatment. In three patients, a decompressive craniectomy was performed due to elevated intracranial pressure. Eight patients out of nine achieved a good outcome at follow-up (modified Rankin Scale 0-2). One patient died. No patients experienced recurrence of CVST.
  
  
  CONCLUSIONS
  Aggressive combined endovascular and neurosurgical treatment of patients with severe CVST is associated with a good clinical outcome in the cases in which the patient's clinical condition deteriorates despite standard anticoagulation therapy.
  
  
  BACKGROUND
  not relevant.
  
  
  BACKGROUND
  not relevant.
authors.affiliation: Neurokirurgisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. frantz.r.poulsen@rsyd.dk.
authors.forename: Frantz Rom
authors.initials: FR
authors.lastname: Poulsen
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Høgedal
authors.forename: Margit V
authors.initials: MV
authors.lastname: Stilling
authors.forename: Peter F
authors.initials: PF
authors.lastname: Birkeland
authors.forename: Mette K
authors.initials: MK
authors.lastname: Schultz
authors.forename: Jørgen N
authors.initials: JN
authors.lastname: Rasmussen
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D054022:Cerebrum; D003392:Cranial Sinuses / Q000601:surgery*; D056424:Decompressive Craniectomy; D004322:Drainage; D057510:Endovascular Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology* / Q000601:surgery; D008297:Male; D061185:Mechanical Thrombolysis; D012189:Retrospective Studies; D017131:Thrombectomy; D013927:Thrombosis / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D055815:Young Adult
chemical_list: D000925:Anticoagulants