title: The effects of feed-borne Fusarium mycotoxins and glucomannan in turkey poults based on specific and non-specific parameters.
abstract: An experiment was conducted to investigate the effects of feeding grains naturally contaminated with Fusarium mycotoxins and a yeast derived glucomannan mycotoxin adsorbent (GMA) on selected specific and non-specific parameters in turkey poults. Two hundred and forty 1-day-old male turkey poults were fed the experimental diets for twelve weeks. Experimental diets were formulated with control grains, control grains+0.2% GMA, naturally-contaminated grains, or naturally-contaminated grains+0.2% GMA. Deoxynivalenol (DON) was the major contaminant of the contaminated grains and concentrations varied from 4.0 to 6.5 mg/kg in the contaminated diets. Non-specific parameters measured included: performance parameters, plasma biochemistry profiles, morphometry and CD8(+) T-lymphocyte counts in the duodenum. Plasma concentrations of DON and de-epoxydeoxynivalenol (DOM-1) were used as specific parameters. Performance parameters and plasma biochemistry were altered by the feeding of contaminated diets and GMA but this was not consistent throughout the trial. The feeding of contaminated diets reduced duodenal villus height and apparent villus surface area. This effect was prevented by GMA supplementation. The feeding of contaminated diets elevated total duodenal CD8(+) T-lymphocyte counts but this effect was not prevented by GMA. No significant differences were seen in plasma concentrations of DON and DOM-1 comparing birds fed contaminated and contaminated+GMA diets suggesting that GMA did not prevent DON absorption under these conditions.
authors.affiliation: Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, N1G 2W1 Ontario, Canada; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: mathias.devreese@ugent.be.
authors.forename: Mathias
authors.initials: M
authors.lastname: Devreese
authors.affiliation: Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, N1G 2W1 Ontario, Canada.
authors.forename: George N
authors.initials: GN
authors.lastname: Girgis
authors.affiliation: Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, N1G 2W1 Ontario, Canada.
authors.forename: Si-Trung
authors.initials: ST
authors.lastname: Tran
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Siegrid
authors.initials: S
authors.lastname: De Baere
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
authors.affiliation: Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, N1G 2W1 Ontario, Canada.
authors.forename: Trevor K
authors.initials: TK
authors.lastname: Smith
mesh_terms: D000821:Animal Feed; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D005670:Fusarium / Q000737:chemistry*; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D009183:Mycotoxins / Q000097:blood / Q000633:toxicity*; D014255:Trichothecenes / Q000097:blood / Q000633:toxicity; D014422:Turkeys / Q000254:growth & development*
chemical_list: D008351:Mannans; D009183:Mycotoxins; D014255:Trichothecenes; C022901:(1-6)-alpha-glucomannan; C007262:deoxynivalenol
keywords: Efficacy; Fusarium; Glucomannan; Mycotoxin binder; Mycotoxins; Turkey poults