title: Trivalent chromatin marks the way in.
abstract: Recently in Cell, Wapinski et al. (2013) investigated the epigenetic mechanisms underlying the direct conversion of fibroblasts to induced neurons (iNs). They found that Ascl1 acts as a pioneer factor at neurogenic loci marked by a closed "trivalent" chromatin state in cells permissive to direct conversion, but not in restrictive cell types.
authors.affiliation: Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, 10 Amistad, 201B, New Haven, CT 06520, USA.
authors.forename: Eriona
authors.initials: E
authors.lastname: Hysolli
authors.forename: In-Hyun
authors.initials: IH
authors.lastname: Park
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D004622:Embryo, Mammalian / Q000166:cytology*; D005347:Fibroblasts / Q000166:cytology*; D053263:Gene Regulatory Networks; D006801:Humans; D009474:Neurons / Q000166:cytology*