title: Serum paraoxonase and arylesterase activities and oxidative stress levels in patients with SSRI intoxication.
abstract: Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with selective serotonin reuptake inhibitor (SSRI) intoxication. A total of 11 patients with SSRI intoxication and 20 healthy controls were enrolled. The serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as the paraoxonase and arylesterase activities, were measured spectrophotometrically. The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower (for all, p < 0.001), whereas the serum MDA levels were significantly higher in the patients with SSRI intoxication than in the controls (p < 0.001). These results indicated that decreased PON1 activity and increased oxidative stress represent alternative mechanisms in SSRI toxicity. More studies are needed to elucidate the role of PON1 activity in the etiology of SSRI intoxication.
authors.affiliation: Department of Emergency Medicine, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Celal
authors.initials: C
authors.lastname: Katı
authors.forename: Sevdegul
authors.initials: S
authors.lastname: Karadas
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Hayriye
authors.initials: H
authors.lastname: Gonullu
authors.forename: Latif
authors.initials: L
authors.lastname: Duran
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D062787:Drug Overdose / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics*
chemical_list: D000975:Antioxidants; D043303:Aryldialkylphosphatase; D002265:Carboxylic Ester Hydrolases; D016877:Oxidants; D017367:Selective Serotonin Reuptake Inhibitors; C019734:arylesterase