title: Copper-catalyzed oxidative ring closure and carboarylation of 2-ethynylanilides.
abstract: A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C-O and C-C bonds.
authors.affiliation: MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös University , Pázmány Péter stny. 1/a, H-1117 Budapest, Hungary , Servier Research Institute of Medicinal Chemistry , Záhony utca 7, H-1031 Budapest, Hungary , and Research Centre for Natural Sciences, Hungarian Academy of Sciences , Pusztaszeri út 59-67, H-1025 Budapest, Hungary.
authors.forename: Ádám
authors.initials: Á
authors.lastname: Sinai
authors.forename: Ádám
authors.initials: Á
authors.lastname: Mészáros
authors.forename: Tamás
authors.initials: T
authors.lastname: Gáti
authors.forename: Veronika
authors.initials: V
authors.lastname: Kudar
authors.forename: Anna
authors.initials: A
authors.lastname: Palló
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Novák
mesh_terms: D000813:Anilides / Q000737:chemistry*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000813:Anilides; D048588:Benzoxazines; D009861:Onium Compounds; D003300:Copper