title: Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc.
abstract: Accumulation of oxidative stress is considered to be a causative mediator of kidney disease, and oxidative stress can affect some key regulators of kidney homeostasis and control a number of signaling pathways that are relevant to kidney disease. The p66Shc adaptor protein was discovered more than two decades ago as a pivotal regulator of oxidative stress. Given the importance of oxidative stress in kidney homeostasis, several molecular and cellular studies using a p66Shc antagonist have depicted a role for p66Shc in renal pathophysiology. The specificity of p66Shc functions may depend upon their intracellular localization and expression in the kidney. This review focuses on the biochemical functions of the p66Shc adaptor protein, as well as its potential implications in the pathophysiology of kidney disease. In addition, the concept that pharmacologic modulation of p66Shc expression and activity may serve as a novel and effective target for the treatment of kidney disease is discussed.
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Kidney Institute of Central South University , Changsha, Hunan Province , China.
authors.forename: Shi-Kun
authors.initials: SK
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Xiao
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Fuyou
authors.initials: F
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
mesh_terms: D017209:Apoptosis; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D055765:Shc Signaling Adaptor Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
chemical_list: C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1