title: Oral intralipid emulsion use: a novel therapeutic approach to pancreatic β-cell injury caused by malathion toxicity in rats.
abstract: We aimed to investigate whether oral intralipid emulsion (OIE) reduces pancreatic β-cell injury (PβCI) by chelating with malathion (M), or increases PβCI by increasing M absorption in the stomach. Fifty rats were randomly divided into six groups: control group (C); OIE administered group (L); M-treated group (M); OIE-administered group immediately after given M (M0L); OIE-administered group 6 hours after being given M (M6L) and OIE administered group 12 hours after being given M (M12L). M induced PβCI, hyperglycemia, temporary hyperinsulinemia and oxidative stress (OS). However, there was no significant difference in serum levels of glucose, insulin, total oxidants (TOS) and liver TOS between the M0L group and groups C and L. Also, insulin levels of M12L significantly increased, compared to the M6L group. Biochemical results, which were confirmed by histopathology, indicate that administering OIE after 6 hours and immediately after taking M may markedly prevent PβCI, hyperglycemia and OS. In addition, OIE's effectiveness decreased after 6 hours and was totally ineffective after 12 hours. We concluded that OIE may help to achieve a better prognosis and reduce mortality rate in cases presented to the emergency department, particularly within the first 6 hours, resulting from organophosphate pesticide poisoning by oral ingestion.
authors.affiliation: Department of Anesthesiology and Reanimation .
authors.forename: Kasim
authors.initials: K
authors.lastname: Tuzcu
authors.forename: Harun
authors.initials: H
authors.lastname: Alp
authors.forename: Tumay
authors.initials: T
authors.lastname: Ozgur
authors.forename: Murat
authors.initials: M
authors.lastname: Karcioglu
authors.forename: Isil
authors.initials: I
authors.lastname: Davarci
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Ali
authors.initials: A
authors.lastname: Karakus
authors.forename: Sedat
authors.initials: S
authors.lastname: Hakimoglu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004655:Emulsions / Q000494:pharmacology; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control; D007306:Insecticides / Q000633:toxicity*; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000473:pathology; D008294:Malathion / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010743:Phospholipids / Q000494:pharmacology*; D051381:Rats; D013024:Soybean Oil / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D004655:Emulsions; D007306:Insecticides; D010743:Phospholipids; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil; D008294:Malathion
keywords: Malathion; oral intralipid emulsion; organophosphate intoxication; pancreatic β-cell injury