title: [Studies on absorption kinetics characteristics of diterpenoid alkaloids in rats after oral administration of Sini Tang powder].
abstract: The purpose of this study was to investigate the absorption kinetics of aconitine, mesaconitine and hypaconitine in rats after oral administration of Sini Tang powder. With cannulate portal and jugular veins cannulated (double-cannulate), conscious moving rats were orally administered Sini Tang. Then samples of portal and systemic blood were collected at the designated periods of time and analyzed for aconitine, mesaconitine and hypaconitine by HPLC. Apparent absorption coefficient of aconitine, mesaconitine and hypaconitine was caculated respectively. The results indicated that the apparent absorption coefficient of aconitine, mesaconitine and hypaconitine come from Sini Tang were 0. 336, 0. 090, 0. 176, respectively, which had some differences among them. It was also suggested that double-cannulated rat was useful for estimating the absorption kinetics of aconitine, mesaconitine and hypaconitine after orally administered Sini Tang by determining the AUC values for drugs in portal and systemic blood samples. The three alkaloids could all be detected in blood, but the absorption differences were existed among the three alkaloids.
authors.affiliation: Hangzhou Red Cross Hospital, Hangzhou 310003, China. 106433093@qq.com
authors.forename: Chang-Jiang
authors.initials: CJ
authors.lastname: Lv
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Wang
authors.forename: Dong-Bo
authors.initials: DB
authors.lastname: Dai
authors.forename: Fan-Zhu
authors.initials: FZ
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Wei
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D004224:Diterpenes / Q000097:blood / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D007700:Kinetics; D008297:Male; D011208:Powders / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D011208:Powders; C478756:sini tang