title: Reduced cortical thickness with increased lifetime burden of PTSD in OEF/OIF Veterans and the impact of comorbid TBI.
abstract: Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) in military personnel is increasing dramatically following the OEF/OIF conflicts and is associated with alterations to brain structure. The present study examined the relationship between PTSD and cortical thickness, and its possible modification by mTBI, in a 104-subject OEF/OIF veteran cohort ranging in age from 20 to 62 years. For each participant, two T1-weighted scans were averaged to create high-resolution images for calculation of regional cortical thickness. PTSD symptoms were assessed using the Clinician Administered PTSD Scale (CAPS) and scores were derived based on the previous month's symptoms ("current") and a Cumulative Lifetime Burden of PTSD (CLB-P) reflecting the integral of CAPS scores across the lifetime. Mild TBI was diagnosed using the Boston Assessment of TBI-Lifetime (BAT-L). Results demonstrated a clear negative relationship between current PTSD severity and thickness in both postcentral gyri and middle temporal gyri. This relationship was stronger and more extensive when considering lifetime burden (CLB-P), demonstrating the importance of looking at trauma in the context of an individual's lifetime, rather than only at their current symptoms. Finally, interactions with current PTSD only and comorbid current PTSD and mTBI were found in several regions, implying an additive effect of lifetime PTSD and mTBI on cortical thickness.
authors.affiliation: Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Lindemer
authors.forename: David H
authors.initials: DH
authors.lastname: Salat
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Leritz
authors.forename: Regina E
authors.initials: RE
authors.lastname: McGlinchey
authors.forename: William P
authors.initials: WP
authors.lastname: Milberg
keywords: Comorbidity; Cortical thickness; Mild traumatic brain injury; Neuroimaging; Posttraumatic stress disorder; Whole-brain analysis