title: Intracranial choriocarcinoma occurrence in males: Two cases and a review of the literature.
abstract: Choriocarcinomas generally develop in females. Non-gestational choriocarcinoma in males is extremely rare. The present study describes two cases of young males who were diagnosed with intracranial choriocarcinoma. One case was of an aggressive choriocarcinoma with multiple metastases to the brain, but with an unidentified origin. The patient was admitted in the terminal stage of the cancer. Although a tumor resection was performed, the condition of the patient rapidly deteriorated and chemotherapy was not recommended. The patient succumbed nine days after the surgery. The second case was of a primary ventricular choriocarcinoma. The patient was hospitalized for acute hydrocephalus caused by a mass that was located in the ventricle. Following a tumor resection, the patient underwent a course of whole-brain and spinal radiotherapy. The patient was followed up for more than half a year and remained in a good condition. The present study describes the two cases and a comprehensive review of the literature that was performed to identify similar studies that document choriocarcinomas in males.
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China.
authors.forename: Jianyi
authors.initials: J
authors.lastname: Guo
authors.forename: Chunlong
authors.initials: C
authors.lastname: Zhong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Jiwen
authors.initials: J
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Siyi
authors.initials: S
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Qizhong
authors.initials: Q
authors.lastname: Luo
authors.forename: Jiyao
authors.initials: J
authors.lastname: Jiang
keywords: intracranial choriocarcinomas; male; prognosis; tumorigenesis