title: Interorgan metabolism of valine.
abstract: Oxidation of branched-chain amino acids, leucine, isoleucine and valine, is thought to occur primarily in muscle. Theoretically, however, it is possible for valine carbon to be converted to glucose, a process which only occurs in liver and kidney. We provide evidence that valine is oxidixed toβ-hydroxyisobutyrate in muscle, and that this intermediate is released from muscle and taken up by liver and kidney for subsequent conversion to glucose, thus conserving the gluconeogenic potential of valine.
authors.affiliation: Department of Biochemistry, Memorial University of Newfoundland, St. John's, A1B 3X9, Newfoundland, Canada.
authors.forename: M E
authors.initials: ME
authors.lastname: Brosnan
authors.forename: J
authors.initials: J
authors.lastname: Letto