title: Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Aimee M
authors.initials: AM
authors.lastname: Two
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Tissa R
authors.initials: TR
authors.lastname: Hata
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nakatsuji
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Alvin B
authors.initials: AB
authors.lastname: Coda
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Kotol
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Wiggin
authors.initials: W
authors.lastname: Wu
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA.
authors.forename: Faiza
authors.initials: F
authors.lastname: Shafiq
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA; Therapeutics Clinical Research, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA.
authors.forename: Eugene Y
authors.initials: EY
authors.lastname: Huang
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA. Electronic address: rgallo@ucsd.edu.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gallo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015119:Aminocaproic Acid / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D007611:Aprotinin / Q000737:chemistry; D004311:Double-Blind Method; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007249:Inflammation; D007610:Kallikreins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism; D010865:Pilot Projects; D012393:Rosacea / Q000188:drug therapy* / Q000201:enzymology*; D057057:Serine Proteases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000201:enzymology; D016896:Treatment Outcome; D014357:Trypsin / Q000737:chemistry; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D015842:Serine Proteinase Inhibitors; D007611:Aprotinin; D010447:Peptide Hydrolases; D057057:Serine Proteases; C400147:KLK5 protein, human; D007610:Kallikreins; D014357:Trypsin; D015119:Aminocaproic Acid; D054804:Cathelicidins