title: Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.
abstract: Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.
authors.affiliation: The Neuroscience Institute, Center for Neural Science, School of Medicine, New York University, New York, NY 10016, USA. Electronic address: gyorgy.buzsaki@nyumc.org.
authors.forename: György
authors.initials: G
authors.lastname: Buzsáki
authors.forename: Nikos
authors.initials: N
authors.lastname: Logothetis
authors.forename: Wolf
authors.initials: W
authors.lastname: Singer
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D058256:Brain Waves / Q000235:genetics; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009412:Nerve Fibers / Q000648:ultrastructure; D009434:Neural Pathways / Q000502:physiology / Q000648:ultrastructure; D009929:Organ Size; D010507:Periodicity