title: Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents.
abstract: 2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.
authors.affiliation: Faculty of Pharmacy, Organic Chemistry Department, Al-Azhar University, Cairo 11884, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Alswah
authors.forename: Adel
authors.initials: A
authors.lastname: Ghiaty
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Morsy
authors.forename: Kamal
authors.initials: K
authors.lastname: El-Gamal