title: Homocysteine: cardiovascular risk factor in children and adolescents?
abstract: The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following combination of keywords "homocysteine", "cardiovascular diseases", "child" and "adolescent". Fifteen articles were analyzed showing direct relationship with increasing age (8 studies) and male gender (10 studies), and an inverse relationship with serum vitamins B6, B12 and folate levels. Thus, the results suggest that more research must be carried through in order to determine in a more coherent way the causes of the hiperhomocisteinemia in the pediatric population, guiding for an adequate diet, rich in nutrients necessary to favor the metabolism of the He.
authors.affiliation: Post-graduation Program in Public Health, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil. Electronic address: adriana-aafl@uol.com.br.
authors.forename: Adriana Amorim De Farias
authors.initials: AA
authors.lastname: Leal
authors.forename: Astrid Camêlo
authors.initials: AC
authors.lastname: Palmeira
authors.forename: Gabriella Menezes Almeida De
authors.initials: GM
authors.lastname: Castro
authors.forename: Mônica Oliveira Da Silva
authors.initials: MO
authors.lastname: Simões
authors.forename: Alessandra Teixeira
authors.initials: AT
authors.lastname: Ramos
authors.forename: Carla Campos Muniz
authors.initials: CC
authors.lastname: Medeiros
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D019317:Evidence-Based Medicine; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D014805:Vitamin B 12 / Q000097:blood; D025101:Vitamin B 6 / Q000097:blood; D055815:Young Adult
chemical_list: D006710:Homocysteine; D025101:Vitamin B 6; D014805:Vitamin B 12
keywords: Adolescent; Adolescentes; Cardiovascular diseases; Child; Crianças; Doenças cardiovasculares; Homocisteína; Homocysteine