title: Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation.
abstract: Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids' chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris.
authors.affiliation: Service of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, Brazil ; KOLderma Clinical Trials Institute, Campinas, SP, Brazil.
authors.forename: Adilson
authors.initials: A
authors.lastname: Costa
authors.forename: Aline
authors.initials: A
authors.lastname: Siqueira Talarico
authors.forename: Carla de Oliveira
authors.initials: Cde O
authors.lastname: Parra Duarte
authors.forename: Caroline
authors.initials: C
authors.lastname: Silva Pereira
authors.forename: Ellem Tatiani
authors.initials: ET
authors.lastname: de Souza Weimann
authors.forename: Lissa
authors.initials: L
authors.lastname: Sabino de Matos
authors.forename: Livia Carolina
authors.initials: LC
authors.lastname: Della Coletta
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Fidelis
authors.forename: Thaísa Saddi
authors.initials: TS
authors.lastname: Tannous
authors.forename: Cidia
authors.initials: C
authors.lastname: Vasconcellos