title: Risk factors for liver fibrosis among human immunodeficiency virus monoinfected patients using the FIB4 index in Morocco.
abstract: OBJECTIVE
  To study the prevalence and risk factors of significant hepatic fibrosis in Moroccan human immunodeficiency virus (HIV) monoinfected patients.
  
  
  METHODS
  We conducted a cross-sectional study among HIV monoinfected patients (negative for hepatitis B surface antigen and hepatitis C antibody). Clinical and laboratory data were collected from the data base of the Infectious Diseases Unit in Ibn Rochd Hospital Center [age, gender, duration of HIV infection, CD4 T lymphocyte count, HIV viral load, glycemia and current or prior use of antiretroviral and antiretroviral therapy (ART) duration]. The primary outcome was a FIB4 score > 1.45. Multivariable logistic regression identified independent risk factors for FIB4 > 1.45.
  
  
  RESULTS
  A FIB4 score > 1.45 was identified in 96 among 619 (15.5%). HIV monoinfected patients followed up between September 1990 and September 2012. Multivariate analysis showed that only a viral load > 75 (OR = 2.23, 95%CI: 1.36-3.67), CD4 > 200 cells/mm(3) (OR = 0.39, 95%CI: 0.21-0.72) and age at FIB4 index calculation (OR = 1.10, 95%CI: 1.07-1.13) were independently associated with the occurrence of FIB4 index (> 1.45). Gender, duration of HIV infection, glycemia, use of antiretroviral therapy and ART duration were not associated with significant fibrosis by FIB4.
  
  
  CONCLUSIONS
  FIB4 score > 1.45 was found in 15.5% of Moroccan HIV monoinfected patients. Age, HIV viremia > 75 copies/mL and CD4 count > 200 cells/mm(3) are associated with liver fibrosis. Further studies are needed to explore mechanisms for fibrosis in HIV monoinfected patients.
authors.affiliation: Mohamed Tahiri, Fatima Ez Zahra Lahdami, Wafaa Hliwa, Wafaa Badre, Fouad Haddad, Ahmed Bellabah, Rhimou Alaoui, Department of Hepato-Gastro-Enterology, Ibn Rochd Hospital University Center, Casablanca 20270, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Tahiri
authors.forename: Mustapha
authors.initials: M
authors.lastname: Sodqi
authors.forename: Fatima Ez Zahra
authors.initials: FE
authors.lastname: Lahdami
authors.forename: Latifa
authors.initials: L
authors.lastname: Marih
authors.forename: Hassan
authors.initials: H
authors.lastname: Lamdini
authors.forename: Wafaa
authors.initials: W
authors.lastname: Hliwa
authors.forename: Ahd Oulad
authors.initials: AO
authors.lastname: Lahcen
authors.forename: Wafaa
authors.initials: W
authors.lastname: Badre
authors.forename: Fouad
authors.initials: F
authors.lastname: Haddad
authors.forename: Abdelfetah
authors.initials: A
authors.lastname: Chakib
authors.forename: Ahmed
authors.initials: A
authors.lastname: Bellabah
authors.forename: Rhimou
authors.initials: R
authors.lastname: Alaoui
authors.forename: Kamal Marhoum El
authors.initials: KM
authors.lastname: Filali
keywords: FIB4; Human immunodeficiency virus; Liver; Monoinfected; Risk factors