title: Experience with biodegradable polymer coated sirolimus-eluting coronary stent system in "real-life" percutaneous coronary intervention: 24-month data from the manipal-s registry.
abstract: BACKGROUND
  Despite the undeniable clinical efficacy of drug-eluting stents with durable polymers, concerns regarding their long-term safety have been raised, especially in more complex subsets. The Manipal-S Registry was designed to evaluate the safety and effectiveness of the biodegradable polymer coated Supralimus(®) Sirolimus-Eluting Coronary Stent for the treatment of coronary artery disease, across a wide range of patients who are treated in real-life clinical practice.
  
  
  METHODS
  All the consecutive 116 patients who underwent single-vessel or multiple vessel percutaneous coronary interventions with the use of Supralimus(®) sirolimus-eluting stents between September 2009 and December 2010, were included in this study. Patients were clinically followed-up at 1, 9, 12 and 24 months post-procedure. All clinical, procedural, and follow-up information were collected and analysed.
  
  
  RESULTS
  In total 116 patients, 126 lesions were implanted with 144 stents which had an average stent length of 25.8±8.0 mm. The incidences of any major adverse cardiac and cerebral events at 1, 9, 12 and 24 months were 0, 5 (4.3%), 8 (6.9%), and 10 (8.6%) respectively.
  
  
  CONCLUSIONS
  These 24-month results clearly provide evidence for safety and effectiveness of the Supralimus(®) Sirolimus-eluting coronary stent system with the biodegradable polymer in real-life patients, even in those with acute myocardial infarctions.
authors.affiliation: Associate Professor, Department of Cardiology, KMC , Manipal, Karnataka, India .
authors.forename: Ranjan
authors.initials: R
authors.lastname: Shetty
authors.forename: G
authors.initials: G
authors.lastname: Vivek
authors.forename: Ashok
authors.initials: A
authors.lastname: Thakkar
authors.forename: Supriya Sunder
authors.initials: SS
authors.lastname: Mishra
authors.forename: Vivek
authors.initials: V
authors.lastname: Joseph
authors.forename: Mithun Gopal
authors.initials: MG
authors.lastname: Devraj
authors.forename: Anil
authors.initials: A
authors.lastname: Tumkur
authors.forename: Umesh
authors.initials: U
authors.lastname: Pai
keywords: Biodegradable polymer; Coronary artery disease; Sirolimus-eluting stent