title: Spice, pot, and stroke.
abstract: The endocannabinoid system includes 2 types of G-protein coupled receptors: CB1 (mostly in the brain) and CB2 (in peripheral lymphoid tissue). The major cannabinoid ligands are arachidonylethanolamine ("anandamide," the Sanskrit word for bliss) and 2-arachidonylglycerol ("2AG"). It is by binding to CB1 receptors that δ-9-tetrahydrocannabinol (THC), the principal psychoactive ingredient in marijuana ("pot"), produces its intended subjective effects.
authors.affiliation: From the New York Neurological Institute and Columbia University College of Physicians & Surgeons, NY.
authors.forename: John C M
authors.initials: JC
authors.lastname: Brust
mesh_terms: D002545:Brain Ischemia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D008385:Marijuana Smoking / Q000009:adverse effects*; D009281:Naphthalenes / Q000009:adverse effects*; D020521:Stroke / Q000139:chemically induced*
chemical_list: D013287:Illicit Drugs; D007211:Indoles; D009281:Naphthalenes; C552597:1-pentyl-3-(1-naphthoyl)indole