title: Crevicular fluid and serum concentrations of progranulin and high sensitivity CRP in chronic periodontitis and type 2 diabetes.
abstract: BACKGROUND
  This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM).
  
  
  METHODS
  PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodontitis, and type 2 DM with chronic periodontitis.
  
  
  RESULTS
  The mean PGRN and hs CRP concentrations in serum and GCF were the highest for group 3 followed by group 2 and the least in group 1.
  
  
  CONCLUSIONS
  PGRN and hs CRP may be biomarkers of the inflammatory response in type 2 DM and chronic periodontitis.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka 560002, India.
authors.forename: N
authors.initials: N
authors.lastname: Priyanka
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.forename: Nitish
authors.initials: N
authors.lastname: Kalra
authors.forename: P
authors.initials: P
authors.lastname: Arjun
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis* / Q000097:blood; D008297:Male; D000077153:Progranulins
chemical_list: D015415:Biomarkers; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D002097:C-Reactive Protein