title: Synthesis and in vitro antiproliferative evaluation of some novel B-norcholesterols.
abstract: Some novel B-norcholesterols with different substituted groups were synthesized. The antiproliferative activity of the compounds against cervical carcinoma (HeLa), liver cancer (Bel 7404) and gastric cancer (SGC 7901) cells was assayed. The results revealed that the presence of a 6-alkylthiosemicarbazone or 6-cyano group could enhance the antiproliferative activity of these compounds. The induction of compounds 6 and 9 to cancer cell apoptosis were assayed by flow cytometry, and the results showed that the compounds were able to effectively induce cancer cell apoptosis. The research provided a theoretical reference for the exploration of new anti-cancer drug. The results suggest that compounds 6 and 9 based on its abeo-cholestane may constitute a novel class of antiproliferative agents, which deserve further study.
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gan
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Lin
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China. Electronic address: cuijg1954@126.com.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Jidan
authors.initials: J
authors.lastname: Feng
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Jinni
authors.initials: J
authors.lastname: Guo
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Huoying
authors.initials: H
authors.lastname: Liao
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China. Electronic address: huangyanmin828@163.com.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002784:Cholesterol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002784:Cholesterol
keywords: Antiproliferative activity; Apoptosis; B-norcholesterols; Cholesterol; Synthesis