title: A review of polypeptide-based polymersomes.
abstract: Self-assembled systems from biodegradable amphiphilic polymers at the nanometer scale, such as nanotubes, nanoparticles, polymer micelles, nanogels, and polymersomes, have attracted much attention especially in biomedical ﬁelds. Among these nano-aggregates, polymersomes have attracted tremendous interests as versatile carriers due to their colloidal stability, tunable membrane properties and ability of encapsulating or integrating a broad range of drugs and molecules. Biodegradable block polymers, especially aliphatic polyesters such as polylactide, polyglycolide and poly (ε-caprolactone) have been widely used as biomedical materials for a long time to well fit the requirement of biomedical drug carriers. To have a precise control of the aggregation behavior of nano-aggregates, the more ordered polypeptide has been used to self-assemble into the drug carriers. In this review we focus on the study of polymersomes which also named pepsomes formed by polypeptide-based copolymers and attempt to clarify the polypeptide-based polymersomes from following aspects: synthesis and characterization of the polypeptide-based copolymers, preparation, multifunction and application of polypeptide-based polymersomes.
authors.affiliation: School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, Jinan, Shandong Province 250012, PR China.
authors.forename: Lanxia
authors.initials: L
authors.lastname: Zhao
authors.forename: Nuannuan
authors.initials: N
authors.lastname: Li
authors.forename: Kaiming
authors.initials: K
authors.lastname: Wang
authors.forename: Chunhuan
authors.initials: C
authors.lastname: Shi
authors.forename: Longlong
authors.initials: L
authors.lastname: Zhang
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Luan
mesh_terms: D000818:Animals; D058045:Artificial Cells / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D010455:Peptides; D011108:Polymers; D013501:Surface-Active Agents
keywords: Application; Multifunction; Polymersome; Polypeptide-based amphiphilic copolymer; Preparation; Synthesis