title: Enhanced oral bioavailability and antiasthmatic efficacy of curcumin using redispersible dry emulsion.
abstract: Dry emulsion containing curcumin (DE-CUR) was prepared for oral delivery of poorly water-soluble curcumin, and its oral bioavailability and antiasthmatic efficacy was evaluated. After comparison of the solubility of curcumin in various oils, Plurol® Oleique CC497 was selected to be the oil phase due to its higher solubility of CUR than other oils. A dry emulsion prepared by spray-drying of a homogenized oil-in-water emulsion was well-reconstituted in water, fabricating similar particle distribution and in vitro release to that of a dispersed homogeneous emulsion before spraying. The release of DE-CUR was much higher than that of curcumin (85.3 vs. 1.7% release at 60 min). Consequently, DE-CUR resulted in 12.0- and 7.1-fold higher Cmax and AUC0-24h than curcumin. In a murine asthma model, DE-CUR effectively suppressed airway hyperresponsiveness and levels of T-helper cytokines such as interleukin-4, inteleukin-5, and interleukin-13. These findings demonstrate that the DE-CUR shows a potential for the development of functional foods or medicines including CUR.
authors.affiliation: College of Pharmacy, The Catholic University of Korea, Bucheon, Gyeonggi 420-743, Republic of Korea.
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Jang
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Euichaul
authors.initials: E
authors.lastname: Oh
authors.forename: Kooyeon
authors.initials: K
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001249:Asthma / Q000188:drug therapy*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016207:Cytokines / Q000378:metabolism; D004655:Emulsions; D005260:Female; D007073:Immunoglobulin E / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D015233:Models, Statistical; D010316:Particle Size; D004364:Pharmaceutical Preparations; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D004655:Emulsions; D018793:Interleukin-13; D015848:Interleukin-5; D004364:Pharmaceutical Preparations; D014867:Water; D015847:Interleukin-4; D007073:Immunoglobulin E; D003474:Curcumin
keywords: Curcumin; antiasthmatic efficacy; bioavailability; dry emulsion; functional food; poorly water-soluble