title: Friedreich's ataxia, frataxin, PIP5K1B: echo of a distant fracas.
abstract: "Frataxin fracas" were the words used when referring to the frataxin-encoding gene (FXN) burst in as a motive to disqualify an alternative candidate gene, PIP5K1B, as an actor in Friedreich's ataxia (FRDA) (Campuzano et al., 1996; Cossee et al., 1997; Carvajal et al., 1996). The instrumental role in the disease of large triplet expansions in the first intron of FXN has been thereafter fully confirmed, and this no longer suffers any dispute (Koeppen, 2011). On the other hand, a recent study suggests that the consequences of these large expansions in FXN are wider than previously thought and that the expression of surrounding genes, including PIP5K1B, could be concurrently modulated by these large expansions (Bayot et al., 2013). This recent observation raises a number of important and yet unanswered questions for scientists and clinicians working on FRDA; these questions are the substratum of this paper.
authors.affiliation: INSERM UMR 676, Bâtiment Ecran, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris, France ; Université Paris 7, Faculté de Médecine Denis Diderot, Site Robert Debré, 48 boulevard Sérurier, 75019 Paris, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bayot
authors.forename: Pierre
authors.initials: P
authors.lastname: Rustin
mesh_terms: D000818:Animals; D005621:Friedreich Ataxia / Q000201:enzymology* / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D033862:Iron-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000172:deficiency / Q000378:metabolism; D018384:Oxidative Stress; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics; D000096923:Frataxin
chemical_list: D033862:Iron-Binding Proteins; D007506:Iron-Sulfur Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); D000096923:Frataxin; C020077:1-phosphatidylinositol-4-phosphate 5-kinase