title: Determination of magnitudes and relative signs of 1H-19F coupling constants through 1D- and 2D-TOCSY experiments.
abstract: A novel methodology based on 1D- and 2D-TOCSY experiments is described for a quick and accurate measurement of proton-fluorine coupling constants in fluorinated organic compounds. The magnitude of the (1)H-(19)F coupling was measured from the displacement between the relayed peaks associated with the α or β spin state of the fluorine, and its relative sign was derived from the sense of the displacement.
authors.affiliation: Centro de Investigación Básica, Lilly S.A. Avda. de la Industria 30, 28108 Alcobendas-Madrid, Spain.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Espinosa
mesh_terms: D005461:Fluorine / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D011522:Protons
chemical_list: D006845:Hydrocarbons, Fluorinated; D011522:Protons; D005461:Fluorine