title: The Thr241Met polymorphism in the XRCC3 gene is associated with increased risk of cancer in Chinese mainland populations.
abstract: The Thr241Met polymorphism in XRCC3 gene may affect the DNA repair pathways and be associated with the risk of cancer. However, the results of previous studies are inconsistent in Chinese mainland populations. The objective of this study is to investigate the association between the Thr241Met polymorphism in XRCC3 gene and risk of cancer for the Chinese Mainland populations by meta-analysis. We searched PubMed database, Embase database, CNKI database, and Wanfang database, and the last search was updated on July 24, 2013. Statistical analysis was performed using RevMan4.2 and Stata10.0 software. Finally, a total of 23 case-control studies in 23 articles were included. The results suggested a significant association between the Thr241Met polymorphism in XRCC3 gene and cancer risk in Chinese mainland populations (Met/Met + Thr/Met vs. Thr/Thr: OR = 1.25, 95 % CI = 1.02-1.54, P = 0.04). In the subgroup analyses by cancer types, significant associations were found in cervical cancer and nasopharyngeal cancer. The current meta-analysis suggested that the Thr241Met polymorphism in the XRCC3 gene may be a risk factor for cancer in Chinese mainland populations. In the future, more case-control studies are needed to validate these results.
authors.affiliation: West China Hospital/West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Xiong
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Yayi
authors.initials: Y
authors.lastname: Wang
authors.forename: Jiani
authors.initials: J
authors.lastname: Shen
authors.forename: Yuanling
authors.initials: Y
authors.lastname: Peng
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Jia
authors.forename: Jiqiao
authors.initials: J
authors.lastname: Yang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
mesh_terms: D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D005828:Genetics, Population; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3