title: Neuroblastoma cells as possible model in the study of glutamate receptors.
abstract: The sensitivity of several cultured neuroblastoma cell lines toL-glutamate (Glu) and its analogues has been studied with the whole-cell patch clamp technique. Only in the neuroblastoma cell line N2A Glu induced a concentration dependent response consisting of an inward current. In addition, N2A cells responded to superfusion with kainate, quisqualate orN-methyl-D-aspartate, but to a lesser degree than to Glu. It is concluded that N2A cells could be useful as anin vitro model to study excitatory amino acid properties.
authors.affiliation: Research Institute of Toxicology, University of Utrecht, P.O. Box 80.176, NL-3508, Utrecht, TD, The Netherlands.
authors.forename: J B
authors.initials: JB
authors.lastname: van der Valk
authors.forename: H P
authors.initials: HP
authors.lastname: Vijverberg