title: New insights in the pathogenesis of atopic dermatitis.
abstract: Atopic dermatitis (AD) is characterized by skin barrier defects and increased interleukin (IL)-4/IL-13 expression. Recent evidence also suggests the involvement of innate immunity including Toll-like receptors, IL-33, IL-25, and innate lymphoid cells in the pathogenesis of AD. This article reviews these innate immune components and how they may become an integral part of prognostic factors and therapeutic targets in the treatment of AD.
authors.affiliation: 1] Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Peck Y
authors.initials: PY
authors.lastname: Ong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007381:Intermediate Filament Proteins / Q000235:genetics; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology; D009154:Mutation; D010641:Phenotype; D012307:Risk Factors; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins