title: [Preliminary study on pelvic organ prolapse treated by using small intestinal submucosa mesh].
abstract: OBJECTIVE
  To study clinical efficacy of porcine-derived small intestinal submucosa (Surgisis) in treatment of pelvic organ prolapse (POP).
  
  
  METHODS
  From Mar. 2012 to Mar. 2013, 15 patients with POP at more than III of POP quantitation (POP-Q) staging system undergoing pelvic reconstructive surgery with Surgisis in Peking University People's Hospital. The mean age was 59 years old (39-82). The variable site of POP-Q staging system was compared between preoperative and postoperative status among those patients.Quality of life questionnaire of pelvic floor impact questionnaire (PFIQ-7), pelvic floor distress inventory short form (PFDI-20) and PISQ-31 were studied to evaluate subjective satisfaction, recurrence and the quality of life's improvement.
  
  
  RESULTS
  All patients were followed up at mean of 9.9 months (3-15 months), the mean time of surgery was 96 mins (65-120 mins), the mean blood loss was 159 ml (50-500 ml).No infection and erosion was observed on those patients. The rate of subjective satisfaction was 14/15, the recurrence rate of prolapse was 2/15.Scoring system of PFDI-20 was from 87 (56-124) at operative status to 30 (22-48) at postoperative status. PFIQ-20 was from 129 (85-158) at preoperative status to 24 (18-48) at postoperative status. PISQ-31 was from 48 (32-55) at preoperative status to 79 (66-89) at postoperative status, which all reached statistical difference (all P < 0.05). Total 9 patients obtained satisfactory sexual life.
  
  
  CONCLUSIONS
  The short-term clinical effect of pelvic reconstructive surgery with Surgisis was satisfied, quality of life and sexual life was improved, and less complication were observed. However, long-term clinical effect on patients should be warranted to follow up.
authors.affiliation: Department of Obstetrics and Gyncology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Sun
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Geng
authors.forename: Jian-liu
authors.initials: JL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007045:Hysterectomy, Vaginal; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small / Q000637:transplantation*; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000473:pathology / Q000601:surgery*; D011788:Quality of Life; D019651:Plastic Surgery Procedures / Q000379:methods*; D012008:Recurrence; D012720:Severity of Illness Index; D013526:Surgical Mesh; D011795:Surveys and Questionnaires; D013552:Swine; D014183:Transplantation, Heterologous; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000601:surgery; D014621:Vagina / Q000601:surgery
chemical_list: D001672:Biocompatible Materials