title: Significance of postoperative changes in hemodynamics and biochemical indices in pediatric recipients of live-donor liver transplants.
abstract: OBJECTIVE
  The aim of this study was to evaluate the postoperative changes in hemodynamics and biochemical indices in pediatric recipients of live-donor liver transplants (LDLT).
  
  
  METHODS
  Hemodynamics and biochemical indices (coagulation function, electrolytes, kidney function, liver function, and blood analysis) were monitored on the day before and the 1st, 3rd, 5th, and 7th days after the procedure in 20 children who underwent LDLT from June 2006 to January 2009.
  
  
  RESULTS
  Compared with preoperative measurements, systolic and diastolic blood pressure and mean arterial pressure increased and prothrombin time was prolonged significantly during the first 7 days after LDLT (P < .05). Fibrinogen, platelet count, total protein, globulin, and blood magnesium decreased significantly (P < .05). Liver enzymes (aspartate transaminase [AST], alanine transaminase [ALT]) and blood sodium increased significantly; serum potassium and calcium declined on the first postoperative day (P < .05). On the 7th day, AST returned to nearly normal (P < .05) and ALT returned to the preoperative levels. Blood urea nitrogen fluctuated within the normal range (P < .05). Total and direct bilirubin decreased on the 1st day but returned to near normal levels on the 7th day (P <.001).
  
  
  CONCLUSIONS
  Our data demonstrated postoperative changes in hemodynamics, electrolytes, and biochemical indices in pediatric LDLT recipients. The changes in clotting factors and platelet count did not result in severe coagulation function disorder; kidney function was normal. Changes in liver enzymes and bilirubin compared with the preoperation indices were within the regulatory scope of liver and did not result in severe complications. These preliminary postoperative trends suggest that further prospective evaluation is needed.
authors.affiliation: Intensive Care Unit, Key Medical Laboratory of Pediatrics, Chongqing Health Bureau, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Hu
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002412:Cations / Q000097:blood; D002648:Child; D006439:Hemodynamics; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D011184:Postoperative Period
chemical_list: D002412:Cations; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase