title: Characterization and in vivo biological performance of biosilicate.
abstract: After an introduction showing the growing interest in glasses and glass-ceramics as biomaterials used for bone healing, we describe a new biomaterial named Biosilicate. Biosilicate is the designation of a group of fully crystallized glass-ceramics of the Na₂O-CaO-SiO₂-P₂O₅ system. Several in vitro tests have shown that Biosilicate is a very active biomaterial and that the HCA layer is formed in less than 24 hours of exposure to "simulated body fluid" (SBF) solution. Also, in vitro studies with osteoblastic cells have shown that Biosilicate disks supported significantly larger areas of calcified matrix compared to 45S5 Bioglass, indicating that this bioactive glass-ceramic may promote enhancement of in vitro bone-like tissue formation in osteogenic cell cultures. Finally, due to its special characteristics, Biosilicate has also been successfully tested in several in vivo studies. These studies revealed that the material is biocompatible, presents excellent bioactive properties, and is effective to stimulate the deposition of newly formed bone in animal models. All these data highlight the huge potential of Biosilicate to be used in bone regeneration applications.
authors.affiliation: Department of Biosciences, Federal University of São Paulo, Avenida Ana Costa 95, 11060-001 Santos, SP, Brazil.
authors.forename: Ana Claudia M
authors.initials: AC
authors.lastname: Renno
authors.forename: Paulo Sérgio
authors.initials: PS
authors.lastname: Bossini
authors.forename: Murilo C
authors.initials: MC
authors.lastname: Crovace
authors.forename: Ana Candida M
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Edgar Dutra
authors.initials: ED
authors.lastname: Zanotto
authors.forename: Nivaldo Antonio
authors.initials: NA
authors.lastname: Parizotto
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology* / Q000627:therapeutic use; D001843:Bone Cements / Q000494:pharmacology / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects; D002516:Ceramics / Q000494:pharmacology / Q000627:therapeutic use; D003807:Dentin Sensitivity / Q000188:drug therapy; D006801:Humans; D017640:Silicates / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D017640:Silicates; C023506:Glass ceramics