title: Virus entry mediated by hepatitis B virus envelope proteins.
abstract: Hepatitis B virus (HBV), a major cause of human liver disease worldwide, encodes three envelope proteins needed for the attachment and entry of the virus into susceptible host cells. A second virus, hepatitis delta virus, which is known to enhance liver disease in HBV infected patients, diverts the same HBV envelope proteins to achieve its own assembly and infection. In the lab, lentiviral vectors based on human immunodeficiency virus type 1 can be assembled using the HBV envelope proteins, and will similarly infect susceptible cells. This article provides a partial review and some personal reflections of how these three viruses infect and of how recipient cells become susceptible, along with some consideration of questions that remain to be answered.
authors.affiliation: John M Taylor, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D015497:HIV-1 / Q000378:metabolism / Q000472:pathogenicity; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D003698:Hepatitis Delta Virus / Q000378:metabolism / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D053585:Virus Attachment; D053586:Virus Internalization / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D014759:Viral Envelope Proteins
keywords: Entry; Envelope proteins; Hepatitis B virus; Hepatitis delta virus; Receptor