title: Evolution and emergence of a new era of antiviral treatment for chronic hepatitis C infection.
abstract: Chronic hepatitis C virus (HCV) infection is a major public health burden associated with significant morbidity and mortality. The approval of telaprevir and boceprevir for use with interferon and ribavirin in chronic HCV infection significantly increased viral eradication but has been accompanied by increased adverse events and therefore inferior clinical tolerance. Newer classes of antiviral agents, such as directly acting antiviral and host-targeting agents, offer a combination of drugs without the need for interferon and can achieve better response rates with a shorter duration of treatment. This offers an exciting prospect in the new era of antiviral treatment for HCV infection.
authors.affiliation: Centre for Liver Research and NIHR Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. Electronic address: t.r.lim@bham.ac.uk.
authors.forename: T R
authors.initials: TR
authors.lastname: Lim
authors.affiliation: Digestive Diseases Centre, NIHR Biomedical Research Unit, Queen's Medical Centre, Nottingham, UK.
authors.forename: B H
authors.initials: BH
authors.lastname: Tan
authors.affiliation: Centre for Liver Research and NIHR Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Mutimer
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000379:methods / Q000639:trends; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D009842:Oligopeptides / Q000009:adverse effects / Q000627:therapeutic use; D011392:Proline / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D009842:Oligopeptides; C486464:telaprevir; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide; D011392:Proline
keywords: Antiviral treatment; Directly acting antiviral; Hepatitis C