title: Acute respiratory distress syndrome and acute renal failure from Plasmodium ovale infection with fatal outcome.
abstract: BACKGROUND
  Plasmodium ovale is one of the causative agents of human malaria. Plasmodium ovale infection has long been thought to be non-fatal. Due to its lower morbidity, P. ovale receives little attention in malaria research.
  
  
  METHODS
  Two Malaysians went to Nigeria for two weeks. After returning to Malaysia, they fell sick and were admitted to different hospitals. Plasmodium ovale parasites were identified from blood smears of these patients. The species identification was further confirmed with nested PCR. One of them was successfully treated with no incident of relapse within 12-month medical follow-up. The other patient came down with malaria-induced respiratory complication during the course of treatment. Although parasites were cleared off the circulation, the patient's condition worsened. He succumbed to multiple complications including acute respiratory distress syndrome and acute renal failure.
  
  
  RESULTS
  Sequencing of the malaria parasite DNA from both cases, followed by multiple sequence alignment and phylogenetic tree construction suggested that the causative agent for both malaria cases was P. ovale curtisi.
  
  
  CONCLUSIONS
  In this report, the differences between both cases were discussed, and the potential capability of P. ovale in causing severe complications and death as seen in this case report was highlighted.
  
  
  CONCLUSIONS
  Plasmodium ovale is potentially capable of causing severe complications, if not death. Complete travel and clinical history of malaria patient are vital for successful diagnoses and treatment. Monitoring of respiratory and renal function of malaria patients, regardless of the species of malaria parasites involved is crucial during the course of hospital admission.
authors.affiliation: Tropical Infectious Disease Research and Education Center (TIDREC), Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. lauyeeling@um.edu.my.
authors.forename: Yee-Ling
authors.initials: YL
authors.lastname: Lau
authors.forename: Wenn-Chyau
authors.initials: WC
authors.lastname: Lee
authors.forename: Lian-Huat
authors.initials: LH
authors.lastname: Tan
authors.forename: Adeeba
authors.initials: A
authors.lastname: Kamarulzaman
authors.forename: Sharifah Faridah
authors.initials: SF
authors.lastname: Syed Omar
authors.forename: Mun-Yik
authors.initials: MY
authors.lastname: Fong
authors.forename: Fei-Wen
authors.initials: FW
authors.lastname: Cheong
authors.forename: Rohela
authors.initials: R
authors.lastname: Mahmud
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology*; D000962:Antimalarials / Q000627:therapeutic use; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009549:Nigeria; D010802:Phylogeny; D041122:Plasmodium ovale / Q000302:isolation & purification*; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000209:etiology*; D017422:Sequence Analysis, DNA; D014195:Travel
chemical_list: D000962:Antimalarials; D016054:DNA, Protozoan; D012337:RNA, Ribosomal, 18S