title: Dose-dependent effects of diallyl disulfide on plasma glucose and free fatty acid levels in rats.
abstract: The acute effects of oral administration of diallyl disulfide (DADS), the major organosulfur compound of garlic, on plasma glucose and free fatty acid (FFA) concentrations were examined in rats. Male, 10-week-old Sprague-Dawley rats were divided into DADS-free and DADS-administered (dose = 10, 20, and 40 mg/kg body weight [BW]) groups. Plasma samples were prepared from whole blood drawn from the tail vein 0, 1, 2, 4, and 6 hr after administration. The stomachs were isolated, and the contents were measured 8 hr after administration. In DADS-administered groups, plasma glucose concentrations were increased in a dose-dependent manner 1 hr after the administration. The increase was transient, except in groups administered 40 mg/kg BW of DADS, in which plasma glucose levels remained significantly higher than the DADS-free levels throughout the experimental period. Similar patterns were observed in the plasma FFA concentrations, although the significant differences were lower than those observed in the plasma glucose concentrations. The gastric contents were dose-dependently elevated after DADS administration. The increase was significant when 20 or 40 mg/kg BW of DADS was administered. These results suggest that oral administration of DADS can mobilize energy substrates into the blood, although a higher dose of DADS slows gastric emptying.
authors.affiliation: Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Ken
authors.initials: K
authors.lastname: Shirato
authors.forename: Shogo
authors.initials: S
authors.lastname: Sato
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tachiyashiki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Imaizumi
mesh_terms: D000284:Administration, Oral; D000498:Allyl Compounds / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004220:Disulfides / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005737:Garlic / Q000737:chemistry*; D005746:Gastric Emptying / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D000498:Allyl Compounds; D001786:Blood Glucose; D004220:Disulfides; D005230:Fatty Acids, Nonesterified; C028009:diallyl disulfide