title: Microwave-assisted efficient synthesis of 2-hydroxydeoxybenzoins from the alkali degradation of readily prepared 3-aryl-4-hydroxycoumarins in water.
abstract: This paper describes an operationally simple, green and efficient approach for the synthesis of 2-hydroxydeoxybenzoins bearing diverse substituents from the microwave-assisted alkali degradation of 3-aryl-4-hydroxycoumarins in water. The latter compounds were readily prepared from the intramolecular Claisen condensation reaction of methyl 2-(2-arylacetoxy)benzoates in the presence of Cs2CO3-acetone, in excellent yields and without laborious workup procedures. This method is highly atom-economic and thus applicable for the large-scale synthesis of 2-hydroxydeoxybenzoins.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University.
authors.forename: Zhong-Zhen
authors.initials: ZZ
authors.lastname: Zhou
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Yan
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Yang
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry*; D000096:Acetone / Q000737:chemistry; D000468:Alkalies / Q000737:chemistry*; D001573:Benzoin / Q000138:chemical synthesis / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D002586:Cesium / Q000737:chemistry; D008872:Microwaves; D014867:Water / Q000737:chemistry
chemical_list: D015110:4-Hydroxycoumarins; D000468:Alkalies; D002254:Carbonates; D014867:Water; D000096:Acetone; D002586:Cesium; D001573:Benzoin; C545311:cesium carbonate