title: Eccrine angiomatous hamartoma is a lymphatic proliferation.
abstract: BACKGROUND
  Eccrine angiomatous hamartoma (EAH) is recognized as a vascular hamartoma composed of abnormal proliferation of blood vessels and eccrine glands.
  
  
  OBJECTIVE
  We sought to investigate the immunohistochemical results of D2-40 and Prox1 in EAH in order to gain further insight into its histogenesis.
  
  
  METHODS
  We collected 21 cases of EAH diagnosed in a dermatology department. Immunohistochemical staining of D2-40 and Prox1 was performed on all cases.
  
  
  RESULTS
  Prox1 was universally positive in the endothelial cells of proliferated vessels in all cases. D2-40 was universally positive in the endothelial cells of proliferated vessels in 3 cases, focally positive in 18 cases.
  
  
  CONCLUSIONS
  EAH is a lymphatic proliferation and therefore we suggest the name of eccrine lymphangiomatous hamartoma.
authors.affiliation: Department of Dermatology, Xijing hospital, Fourth Military Medical University, 15 Changlexi Road, 710032 Xian, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Tianwen
authors.initials: T
authors.lastname: Gao
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004439:Eccrine Glands / Q000737:chemistry* / Q000473:pathology; D042783:Endothelial Cells / Q000737:chemistry; D005260:Female; D006222:Hamartoma / Q000737:chemistry* / Q000473:pathology; D018398:Homeodomain Proteins / Q000032:analysis*; D006801:Humans; D007223:Infant; D042601:Lymphatic Vessels / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013543:Sweat Gland Diseases / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D055815:Young Adult; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; C500987:monoclonal antibody D2-40; D000098551:Prospero-Related Homeobox 1 Protein
keywords: D2-40; Prox1; eccrine angiomatous hamartoma; vascular hamartoma; vascular neoplasm