title: Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging.
abstract: Here, we describe a quantitative neuroimaging method to estimate the macromolecular tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements over a range of field strengths and scan parameters, we tested the key assumptions and the robustness of the method. The measurements confirm that a consistent quantitative estimate of MTV can be obtained across a range of scanners. MTV estimates are sufficiently precise to enable a comparison between data obtained from an individual subject with control population data. We describe two applications. First, we show that MTV estimates can be combined with T1 and diffusion measurements to augment our understanding of the tissue properties. Second, we show that MTV provides a sensitive measure of disease status in individual patients with multiple sclerosis. The MTV maps are obtained using short clinically appropriate scans that can reveal how tissue changes influence behavior and cognition.
authors.affiliation: Department of Psychology, Stanford University, Stanford, California, USA.
authors.forename: Aviv
authors.initials: A
authors.lastname: Mezer
authors.forename: Jason D
authors.initials: JD
authors.lastname: Yeatman
authors.forename: Nikola
authors.initials: N
authors.lastname: Stikov
authors.forename: Kendrick N
authors.initials: KN
authors.lastname: Kay
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Cho
authors.forename: Robert F
authors.initials: RF
authors.lastname: Dougherty
authors.forename: Michael L
authors.initials: ML
authors.lastname: Perry
authors.forename: Josef
authors.initials: J
authors.lastname: Parvizi
authors.forename: Le H
authors.initials: le H
authors.lastname: Hua
authors.forename: Kim
authors.initials: K
authors.lastname: Butts-Pauly
authors.forename: Brian A
authors.initials: BA
authors.lastname: Wandell
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology; D009929:Organ Size; D011859:Radiography; D015203:Reproducibility of Results; D054928:Validation Studies as Topic