title: D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism.
abstract: Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.
authors.affiliation: Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. Electronic address: carole.hyacinthe@u-bordeaux2.fr.
authors.forename: Carole
authors.initials: C
authors.lastname: Hyacinthe
authors.affiliation: Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. Electronic address: quentin.barraud@epfl.ch.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Barraud
authors.affiliation: Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Service de Neurologie, CHU de Bordeaux Haut-Lévêque, Pessac, France. Electronic address: francois.tison@chu-bordeaux.fr.
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.affiliation: Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China. Electronic address: erwan.bezard@u-bordeaux2.fr.
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
authors.affiliation: Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Département de Neurophysiologie Clinique, CHU de Bordeaux Pellegrin, Bordeaux, France. Electronic address: imad.ghorayeb@u-bordeaux2.fr.
authors.forename: Imad
authors.initials: I
authors.lastname: Ghorayeb
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D007980:Levodopa / Q000627:therapeutic use; D008252:Macaca fascicularis; D008253:Macaca mulatta; D020734:Parkinsonian Disorders / Q000150:complications* / Q000188:drug therapy; D019257:Quinpirole / Q000627:therapeutic use; D012890:Sleep / Q000187:drug effects; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy* / Q000209:etiology*; D013686:Telemetry; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: D018491:Dopamine Agonists; D019257:Quinpirole; D007980:Levodopa; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
keywords: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; EDS; EEG; EMG; EOG; Excessive daytime sleepiness; MPTP; Non-human primate; PD; Parkinson's disease; REM; Rapid eye movement sleep; Sleep disorders; electroencephalogram; electromyogram; electrooculogram; excessive daytime sleepiness; rapid eye movement