title: MicroRNA-429 Modulates Hepatocellular Carcinoma Prognosis and Tumorigenesis.
abstract: MicroRNA-429 (miR-429) may modify the development and progression of cancers; however, the role of this microRNA in the hepatocellular carcinoma (HCC) has not been well elaborated. Here, we tested miR-429 expression in 138 pathology-diagnosed HCC cases and SMMC-7721 cells. We found that miR-429 was upregulated in HCC tumor tissues and that the high expression of miR-429 was significantly correlated with larger tumor size (odd ratio (OR), 2.70; 95% confidence interval (CI), 1.28-5.56) and higher aflatoxin B1-DNA adducts (OR = 3.13, 95% CI = 1.47-6.67). Furthermore, this microRNA overexpression modified the recurrence-free survival and overall survival of HCC patients. Functionally, miR-429 overexpression progressed tumor cells proliferation and inhibited cell apoptosis. These results indicate for the first time that miR-429 may modify HCC prognosis and tumorigenesis and may be a potential tumor therapeutic target.
authors.affiliation: Department of Pathology, Youjiang Medical College for Nationalities, Baise 533000, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Huang
authors.forename: Jin-Guang
authors.initials: JG
authors.lastname: Yao
authors.forename: Hong-Dong
authors.initials: HD
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Xi-Dai
authors.initials: XD
authors.lastname: Long