title: A novel subtype of primary prostatic adenocarcinoma: A case report.
abstract: The present study reports the novel case of an 81-year-old male with prostatic adenocarcinoma (PAC), whose histopathological study revealed a pure urothelial carcinoma (UC) that originated, however, from the prostatic glandular epithelium. The levels of serum prostate-specific antigen (PSA) were extraordinarily high in this patient. An MRI scan indicated a prostatic neoplasm and no malignant changes were observed in the bladder or other areas of the urinary tract. Hematoxylin and eosin-stained sections revealed a diagnosis of pure UC with no other form of differentiation (typical adenocarcinoma or squamous differentiation). The immunohistochemical findings were positive for PSA and P504S, and negative for CK7, CK20, 34βE12 and p63. A diagnosis of primary PAC (solid carcinoma) originating from the prostate was made based on the clinical, histopathological and immunohistochemical observations. This case was susceptible to diagnostic errors, however, a novel subtype of primary PAC was identified and termed the UC-like subtype.
authors.affiliation: Tianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Hexi, Tianjin, P.R. China ; Department of Endocrinology, Second Hospital of Tianjin Medical University, Hexi, Tianjin, P.R. China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Jianing
authors.initials: J
authors.lastname: Guo
authors.forename: Chunrui
authors.initials: C
authors.lastname: Yang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Yang
authors.forename: Ruifa
authors.initials: R
authors.lastname: Han
keywords: adenocarcinoma of the prostate; histopathological feature; urothelial carcinoma