title: Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.
abstract: Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa . Their structures were established by detailed interpretation of NMR and MS data, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1-3 and 5 showed potent cytotoxicity against some of the tested tumor cell lines. Sulfur substitution at C-11 or a double bond at C-10 significantly increased the cytotoxic activities of the curvularin analogues.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors.forename: Ling-Hong
authors.initials: LH
authors.lastname: Meng
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Cui-Ting
authors.initials: CT
authors.lastname: Lv
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Gang-Ming
authors.initials: GM
authors.lastname: Xu
authors.forename: Cai-Guo
authors.initials: CG
authors.lastname: Huang
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029764:Combretaceae / Q000382:microbiology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000032:analysis*; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C586159:sumalarin A; C586158:sumalarin B; C586157:sumalarin C; D015025:Zearalenone; D013455:Sulfur; C013455:curvularin