title: Sustained Alzheimer's amyloid pathology in myeloid differentiation protein-88-deficient APPswe/PS1 mice.
abstract: BACKGROUND
  Most Alzheimer's disease (AD) cases arise sporadically and may involve innate immune activation of microglial expressed Toll-like receptors regulated through the myeloid differentiation protein 88 (MyD88) pathway.
  
  
  OBJECTIVE
  It was the aim of this study to test the innate immune involvement in AD pathology.
  
  
  METHODS
  We mated APPsw/PS1ΔE9 mice with MyD88-deficient mice.
  
  
  RESULTS
  Progeny mice had similar levels of soluble amyloid-β peptides, amyloid plaque density and neuroimmune staining patterns. However, double-transgenic mice did show a significantly reduced life expectancy.
  
  
  CONCLUSIONS
  Our findings indicate that impaired innate immune responses may play a role in AD pathology.
authors.affiliation: Department of Biological Chemistry and the Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Goll
authors.forename: U
authors.initials: U
authors.lastname: Bekenstein
authors.forename: S
authors.initials: S
authors.lastname: Barbash
authors.forename: D S
authors.initials: DS
authors.lastname: Greenberg
authors.forename: R
authors.initials: R
authors.lastname: Zangen
authors.forename: S
authors.initials: S
authors.lastname: Shoham
authors.forename: H
authors.initials: H
authors.lastname: Soreq
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D051379:Mice; D008822:Mice, Transgenic; D053594:Myeloid Differentiation Factor 88 / Q000172:deficiency*; D058225:Plaque, Amyloid / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D016229:Amyloid beta-Peptides; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88