title: Transglottic basaloid squamous cell carcinoma of the larynx.
abstract: OBJECTIVE
  To report a rare case of Transglottic Basaloid Squamous cell carcinoma of the larynx and review the pathologic features of these lesions.
  
  
  METHODS
  A 64 year old male, heavy smoker and alcohol abuser, presented with a 6 month history of hoarseness. Laryngoscopy revealed a right transglottic lesion involving the epiglottis, aryepiglottic fold, ventricle and true vocal fold. Microscopically, the tumor was characterized by infiltrating solid sheets of basaloid cells showing palisading pattern along the edges. In areas of solid growth, tumor cells displayed scant cytoplasm, and hyperchromatic nuclei. A portion of the tumor abutting the thyroid cartilage showed squamous differentiation. An island of tumor cells with comedonecrosis was also noted. Immunohistochemical staining for a number of markers was performed.
  
  
  CONCLUSIONS
  Basaloid squamous cell carcinoma displays a biphasic histology. The stage of the disease at presentation is invariably advanced with metastatic lymphadenopathy in two thirds of the patients.
authors.affiliation: Department of Otolaryngology/Head & Neck Surgery, American University of Beirut Medical Center-Lebanon. alhamdan@svclb.com
authors.forename: Abdul-Latif
authors.initials: AL
authors.lastname: Hamdan
authors.forename: Roger
authors.initials: R
authors.lastname: Moukarbel
authors.forename: Ayman
authors.initials: A
authors.lastname: Tawil
authors.forename: Hanna
authors.initials: H
authors.lastname: Kaspar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Natout
mesh_terms: D002281:Carcinoma, Basosquamous / Q000175:diagnosis* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004825:Epiglottis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007828:Laryngoscopy / Q000379:methods; D007830:Larynx / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods