title: Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
abstract: Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (1-6), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 7-17, and 19-22) demonstrated in vitro activities against human tumor cells, and 7 and 8 showed selective cytotoxicity to tumor cells over normal cells.
authors.affiliation: National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962-6109, USA. Electronic address: lis@sfasu.edu.
authors.forename: Shiyou
authors.initials: S
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Guangrui
authors.initials: G
authors.lastname: Deng
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Zushang
authors.initials: Z
authors.lastname: Su
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D058865:Introduced Species; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008610:Menthol / Q000737:chemistry; D008968:Molecular Conformation; D010936:Plant Extracts / Q000633:toxicity*; D064028:Tracheophyta / Q000737:chemistry* / Q000378:metabolism
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D004224:Diterpenes; D005960:Glucosides; D018942:Macrolides; D010936:Plant Extracts; C431074:ferruginol; C000589837:salviniol; D008610:Menthol
keywords: Abietane diterpenes; Cytotoxicity; Giant salvinia; Invasive species; Salvinia molesta; Salviniol; Salviniside