title: Association of LXRα polymorphisms with obesity and obesity-related phenotypes in an Iranian population.
abstract: BACKGROUND
  Obesity is a multifactorial disorder due to the complex interaction between genetic and environmental factors. Liver X receptor alpha (LXRα), encoded by the gene NR1H3, is involved in lipoprotein metabolism and its genetic variations may also play a role in the aetiology of obesity.
  
  
  OBJECTIVE
  To assess the association of two NR1H3 polymorphisms (rs11039155 and rs2279238) and their haplotypes with obesity in an Iranian population.
  
  
  METHODS
  A total of 447 unrelated subjects (including 206 overweight, 162 obese and 79 controls) were enrolled in the study and were genotyped by TaqMan assay using DNA from peripheral blood. The association of these two LXRα polymorphisms with the presence of obesity and overweight was assessed.
  
  
  RESULTS
  There was no significant association between the two SNPs and obesity, even after adjustment for age and sex. By logistic regression using a dominant model, the odds ratios for obesity were: 1.32 (0.85-2.74) for rs11039155 and 0.77 (0.30--1.99) for rs2279238. Haplotype analyses identified three common haplotypes GC, GT and AC with frequency greater than 1%, but none of the haplotypes was associated with the risk of obesity.
  
  
  CONCLUSIONS
  This study revealed that there was no significant association between LXRα polymorphisms and the presence of obesity in an Iranian population and suggests that these two SNPs are not major contributors to obesity risk in this population.
authors.affiliation: Gastroenterology and Liver Diseases Research Center and.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rooki
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Mohamad-Amin
authors.initials: MA
authors.lastname: Pourhosseingholi
authors.forename: Mahmoud-Reza
authors.initials: MR
authors.lastname: Azarpazhooh
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Zali
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D000071518:Liver X Receptors; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D057093:Orphan Nuclear Receptors / Q000235:genetics* / Q000378:metabolism; D050177:Overweight / Q000453:epidemiology / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors