title: Community acquired pneumonia: genetic variants influencing systemic inflammation.
abstract: The inflammatory response depends on several factors, including pathogenicity and duration of the stimulus, and also on the balance between inflammatory and antiinflammatory response. Several studies have presented evidence of the importance of genetic factors in severe infections. The innate immune response prevents the invasion and spread of pathogens during the first hours after infection. Each of the different processes involved in innate immunity may be affected by genetic polymorphisms, which can result in susceptibility or resistance to infection. The results obtained in the different studies do not irrefutably prove the role or function of a gene in the pathogenesis of respiratory infections. However, they can generate new hypotheses, suggest new candidate genes based on their role in the inflammatory response, and constitute a first step in understanding the underlying genetic factors.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrer Agüero
authors.affiliation: Centro de Cuidados Intensivos, Corporación Sanitaria Universitaria Parc Taulí, Hospital Universitario de Sabadell, Universidad Autónoma de Barcelona, Sabadell, Barcelona, España; Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Barcelona, España.
authors.forename: S
authors.initials: S
authors.lastname: Millán
authors.affiliation: Servicio de Neumología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España; Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, España.
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez de Castro
authors.affiliation: Centro de Cuidados Intensivos, Corporación Sanitaria Universitaria Parc Taulí, Hospital Universitario de Sabadell, Universidad Autónoma de Barcelona, Sabadell, Barcelona, España; Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Barcelona, España.
authors.forename: I
authors.initials: I
authors.lastname: Martín-Loeches
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España; Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Sabadell, Barcelona, España. Electronic address: jsolvio@gobiernodecanarias.org.
authors.forename: J
authors.initials: J
authors.lastname: Solé Violán
mesh_terms: D017714:Community-Acquired Infections / Q000235:genetics / Q000276:immunology; D014644:Genetic Variation; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007249:Inflammation / Q000235:genetics* / Q000276:immunology / Q000382:microbiology*; D018410:Pneumonia, Bacterial / Q000235:genetics* / Q000276:immunology
keywords: Community acquired pneumonia; Genetic polymorphisms; Neumonía adquirida en la comunidad; Polimorfismos de un solo nucleótido; Polimorfismos genéticos; Sepsis susceptibility; Single nucleotide polymorphisms; Susceptibilidad a sepsis