title: Pd(0)-Catalyzed methyl transfer on nucleosides and oligonucleotides, envisaged as a PET tracer.
abstract: The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under "ligandless" conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
authors.affiliation: Institut des Sciences Moléculaires, Université de Bordeaux, UMR5255, 351 Cours de la Libération, Talence 33405, France. d.james@u-bordeaux1.fr.
authors.forename: Damien
authors.initials: D
authors.lastname: James
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Escudier
authors.forename: Magali
authors.initials: M
authors.lastname: Szlosek-Pinaud
authors.forename: Eric
authors.initials: E
authors.lastname: Fouquet
mesh_terms: D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D009705:Nucleosides; D009841:Oligonucleotides; D010165:Palladium