title: Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice.
abstract: Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8⁺ T cells. Here we assess the effect of a potent antiviral CD8⁺ T cell response on influenza virus infection of young and aged mice. Our results show that CD8⁺ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.
authors.affiliation: Wistar Institute, Philadelphia, PA 19104, USA ; Drexel University, Philadelphia, PA 19104, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Parzych
authors.forename: L J
authors.initials: LJ
authors.lastname: DiMenna
authors.forename: B P
authors.initials: BP
authors.lastname: Latimer
authors.forename: J C
authors.initials: JC
authors.lastname: Small
authors.forename: S
authors.initials: S
authors.lastname: Kannan
authors.forename: B
authors.initials: B
authors.lastname: Manson
authors.forename: M O
authors.initials: MO
authors.lastname: Lasaro
authors.forename: E J
authors.initials: EJ
authors.lastname: Wherry
authors.forename: H C
authors.initials: HC
authors.lastname: Ertl
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D007117:Immunization, Secondary; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D008168:Lung / Q000473:pathology / Q000821:virology; D018655:Lymphocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D019590:Nucleocapsid Proteins; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D016601:RNA-Binding Proteins / Q000276:immunology; D014758:Viral Core Proteins / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D016207:Cytokines; D007252:Influenza Vaccines; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins