title: Does the stability of proteins in ionic liquids obey the Hofmeister series?
abstract: Understanding the behavior of Hofmeister anions of ionic liquids (ILs) on protein stability helps to shed light on how the anions interact with proteins in aqueous solution and is a long standing object for chemistry and biochemistry. Ions effects play a major role in understanding the physicochemical and biological phenomenon that undertakes the protein folding/unfolding and refolding process. Despite the generality of these effects, our understanding of ions at the molecular-level is still limited. This review offers a tour through past successful investigations and presents a challenge in current research in the field to reassess the possibilities of ions and to apply new strategies. This review highlights on the stability behavior of the proteins and also comparisons of our past research work in the Hofmeister series of ILs. Furthermore, we specifically focus on the critical discussion on the recent findings with existing results and their implications, along with our understanding of the Hofmeister series of anions of ILs on biomolecular stability. A detailed examination of the difference between selective proteins can provide a better understanding of the molecular mechanism of protein folding/unfolding in the presence of the Hofmeister series of ions of ILs.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India.
authors.forename: Awanish
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India. Electronic address: venkatesup@hotmail.com.
authors.forename: Pannuru
authors.initials: P
authors.lastname: Venkatesu
mesh_terms: D000838:Anions / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D017510:Protein Folding; D055550:Protein Stability; D017433:Protein Structure, Secondary; D058767:Protein Unfolding; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D000838:Anions; D052578:Ionic Liquids; D011506:Proteins; D014867:Water
keywords: Amino acids; Biomolecular interactions; Hofmeister series; Ionic liquids; Protein stability