title: Amino acid esters of 9-(2',3'-dihydroxypropyl-1')-adenine are the specific inhibitors of protein synthesis on ribosomes.
abstract: Peptide acceptor properties of phenylalanine and glycine esters of 9'-(2',3'-dihydroxypropyl-1')-adenine and 1-(2',3'-dihydroxypropyl-1')-4-thiouracyl were investigated. All these esters appeared to be powerful inhibitors of polyphenylalanine synthesis in E. coli MRE-600 ribosomes charged with poly U. Like puromycin, esters of adenine derivatives accepted the AcPhe residue from Ac-[(14)C] Phe-tRNA in a ribosomal system charged with poly U. However, peptidyl esters of 9-(2',3'-dihydroxypropyl-1')-adenine remained bound with ribosomes. The structure of the peptide esters synthesized was ascertained after dissociation of ribosomes into subparticles by direct comparison with the synthetic specimens.
authors.affiliation: Institute of Molecular Biology, the U.S.S.R. Academy of Sciences, Moscow, USSR.
authors.forename: B P
authors.initials: BP
authors.lastname: Gottikh
authors.forename: A A
authors.initials: AA
authors.lastname: Krayevsky
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: A A
authors.initials: AA
authors.lastname: Jatsyna
authors.forename: A M
authors.initials: AM
authors.lastname: Kritzyn
authors.forename: C L
authors.initials: CL
authors.lastname: Florentiev