title: Spindle cell carcinoma of the larynx presenting as a vocal fold cyst.
abstract: Spindle cell carcinoma (SPCC) is a rare, malignant variant of squamous cell carcinoma (SCC), which shows biphasic proliferation of the conventional SCC component and malignant spindle shape cells with sarcomatous appearance. We present two cases of SPCC of the true vocal fold that presented as a benign appearing subepithelial mass. We discuss the patient presentation, voice assessment, surgical treatment, and a review of the literature.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Detroit Medical Center, Michigan State University, Detroit, Michigan. Electronic address: Scse9000@aol.com.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Rutt
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Trauma and Emergency Hospital, Malvinas Argentinas, Buenos Aires, Argentina.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Mintz
authors.affiliation: Lakeshore Professional Voice Center, Lakeshore Ear, Nose and Throat Center, Saint Claire Shores, Michigan; Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Christina
authors.initials: C
authors.lastname: Jackson-Menaldi
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Michael
authors.initials: M
authors.lastname: Johns
authors.affiliation: Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: McHugh
authors.affiliation: Lakeshore Professional Voice Center, Lakeshore Ear, Nose and Throat Center, Saint Claire Shores, Michigan; Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Rubin
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003560:Cysts / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014827:Vocal Cords / Q000473:pathology*
keywords: Dysphonia; Laryngeal cancer; Spindle cell; Vocal fold carcinoma