title: De novo membranous nephropathy in renal allograft associated with antibody-mediated rejection and review of the literature.
abstract: A 71-year-old woman with unknown renal failure etiology received living donor transplantation had normal graft function for many years. At 11 years from transplantation, she developed nephrotic syndrome. Allograft biopsy showed membranous nephropathy (MN) and C4d positivity in the peritubular capillaries, suggestive of antibody-mediated rejection. At the time of nephrosis onset, she had new donor-specific antibody positivity. The case is unusual in that the diagnosis of de novo MN is based on evidence that she had antibody-mediated rejection. De novo MN remains relatively uncommon; we have reviewed the literature on this diagnosis.
authors.affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA. Electronic address: kpatel22@partners.org.
authors.forename: K
authors.initials: K
authors.lastname: Patel
authors.forename: J
authors.initials: J
authors.lastname: Hirsch
authors.forename: L
authors.initials: L
authors.lastname: Beck
authors.forename: L
authors.initials: L
authors.lastname: Herlitz
authors.forename: J
authors.initials: J
authors.lastname: Radhakrishnan
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000209:etiology*; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans
chemical_list: D001323:Autoantibodies