title: Oxidative stress-associated protein tyrosine kinases and phosphatases in Fanconi anemia.
abstract: CONCLUSIONS
  Fanconi anemia (FA) is a genetic disorder featuring chromosomal instability, developmental defects, progressive bone marrow failure, and predisposition to cancer. Besides the predominant role in DNA damage response and/or repair, many studies have linked FA proteins to oxidative stress. Oxidative stress, defined as imbalance in pro-oxidant and antioxidant homeostasis, has been considered to contribute to disease development, including FA.
  
  
  BACKGROUND
  A variety of signaling pathways may be influenced by oxidative stress, particularly the equilibrium between protein kinases and phosphatases, consequently leading to an aberrant phosphorylation state of cellular proteins. Dysfunction of kinases/phosphatases has been implicated in the pathophysiology of human diseases. In FA, evidence is emerging that links abnormal phosphorylation/de-phosphorylation of signaling molecules to clinical complications and malformations.
  
  
  RESULTS
  In this study, we review the recent findings on the oxidative stress-related kinases and phosphatases, particularly tyrosine phosphatases in FA.
  
  
  CONCLUSIONS
  Understanding the role of oxidative stress-related kinases and phosphatases in FA may provide unique and generic possibilities for the future development of therapeutic strategies by targeting the dysregulated protein kinases and phosphatases in a clinical setting.
authors.affiliation: 1 Division of Neurosurgery, Center for Theoretic and Applied Neuro-Oncology, Moores Cancer Center, University of California , San Diego, La Jolla, California.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Qishen
authors.initials: Q
authors.lastname: Pang
mesh_terms: D005199:Fanconi Anemia / Q000201:enzymology* / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases