title: A prospective, claims-based assessment of the risk of pancreatitis and pancreatic cancer with liraglutide compared to other antidiabetic drugs.
abstract: OBJECTIVE
  We evaluated the relationship between liraglutide and acute pancreatitis or pancreatic cancer in an ongoing post-marketing safety assessment programme.
  
  
  METHODS
  Initiators of liraglutide, exenatide, metformin, pioglitazone or groups containing initiators of dipeptidyl peptidase-4 inhibitors or sulfonylureas were identified in a US commercial health insurance claims database (1 February 2010 to 31 March 2013) and followed for a median of 15 months. We estimated incidence rates (IR/100 000 person-years), rate ratio (RR) and 95% confidence intervals (CI) of new insurance claims with diagnoses of primary inpatient acute pancreatitis or pancreatic cancer from Poisson regression models.
  
  
  RESULTS
  The IR for acute pancreatitis for liraglutide was 187.5 compared with 154.4 for all non-glucagon-like peptide-1 (GLP-1)-based therapies (adjusted RR 1.10; CI 0.81-1.49). The IR for pancreatic cancer was 19.9 for liraglutide compared with 33.0 for all non-GLP-1-based therapies (adjusted RR 0.65; 95% CI 0.26-1.60).
  
  
  CONCLUSIONS
  We did not observe excess risk of either outcome associated with liraglutide relative to individual or pooled comparator drugs.
authors.affiliation: Optum, Epidemiology, Waltham, MA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Funch
authors.forename: H
authors.initials: H
authors.lastname: Gydesen
authors.forename: K
authors.initials: K
authors.lastname: Tornøe
authors.forename: A
authors.initials: A
authors.lastname: Major-Pedersen
authors.forename: K A
authors.initials: KA
authors.lastname: Chan
mesh_terms: D016208:Databases, Factual; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007344:Insurance Claim Reporting / Q000706:statistics & numerical data; D007348:Insurance, Health; D000069450:Liraglutide; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D010195:Pancreatitis / Q000139:chemically induced*; D011446:Prospective Studies; D018570:Risk Assessment; D013453:Sulfonylurea Compounds / Q000009:adverse effects*; D014481:United States
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1; D008687:Metformin
keywords: GLP-1; observational study; pharmaco-epidemiology