title: Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin D deficiency?
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).
  
  
  METHODS
  Patients who had 25-hydroxyvitamin D3 (25(OH)D3) levels measured were included. Coagulation and hemostatic parameters were evaluated. Patients were divided into 3 groups based on 25(OH)D3 levels as group 1 (25(OH)D3 < 10 ng/mL, n = 25), group 2 (25(OH)D3 = 10-19.9 ng/mL, n = 22), and group 3 (25(OH)D3 ≥ 20 ng/mL, n = 28).
  
  
  RESULTS
  A total of 75 patients with a mean age of 39 (range 18-57) years were included in the study. Prothrombin time was longer in group 3 than in group 2 (P = .043). The TFPI levels were higher in group 3 than in the other groups (P < .001). There was a strong positive correlation between 25(OH)D3 and TFPI levels (r = .47, P < .001).
  
  
  CONCLUSIONS
  Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency.
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey oyasude@gmail.com.
authors.forename: Oya
authors.initials: O
authors.lastname: Topaloglu
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Muyesser Sayki
authors.initials: MS
authors.lastname: Arslan
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Melia
authors.initials: M
authors.lastname: Karakose
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Bekir
authors.initials: B
authors.lastname: Ucan
authors.affiliation: Department of Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ginis
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Evrim
authors.initials: E
authors.lastname: Cakir
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Esra Tutal
authors.initials: ET
authors.lastname: Akkaymak
authors.affiliation: Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozbek
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Cakal
authors.affiliation: Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000235:genetics*; D008297:Male; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor
keywords: hemostasis; thrombosis; tissue factor pathway inhibitor; vitamin D deficiency