title: Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.
abstract: Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China.
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Shou-De
authors.initials: SD
authors.lastname: Zhang
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Xue
authors.initials: X
authors.lastname: Tang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D038143:Inula / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008070:Lipopolysaccharides; D045787:Sesquiterpenes, Eudesmane; D045788:Sesquiterpenes, Germacrane; D009569:Nitric Oxide
keywords: Asteraceae; Cytotoxicity; Eudesmane; Germacrane; Inula wissmanniana Hand.-Mazz.; NO production