title: Changes in acaricidal potency by introducing functional radicals and an acaricidal constituent isolated from Schizonepeta tenuifolia.
abstract: The acaricidal potential of an active constituent isolated from Schizonepeta tenuifolia oil and its structurally related derivatives was evaluated using filter paper and impregnated cotton fabric disk bioassays against house dust and stored food mites. The acaricidal constituent of S. tenuifolia oil was isolated by chromatographic techniques and identified as 2-isopropyl-5-methylcyclohexanone by GC-MS, (1)H-, and (13)C NMR spectra. 2-Isopropyl-5-methylcyclohexanone was a potent acaricide against house dust and stored food mites, based on the LD50 values from the filter paper and impregnated cotton fabric disk bioassays, followed by 4-isopropylcyclohexanone, 2-isopropylidene-5-methylcyclohexanone, 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone, and benzyl benzoate. Furthermore, 4-isopropylcyclohexanone and 2-isopropyl-5-methylcyclohexanone, which were introduced on the isopropyl (C3H7) functional radical of the cyclohexanone skeleton, had the highest acaricidal potency. These results indicate that S. tenuifolia oil and 2-isopropyl-5-methylcyclohexanone structural analogues could be effective natural acaricides for managing house dust and stored food mites.
authors.affiliation: Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Science, Chonbuk National University , Jeonju 561-756, Republic of Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D056810:Acaricides / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D003512:Cyclohexanones / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D003368:Gossypium; D019686:Lamiaceae / Q000737:chemistry*; D007928:Lethal Dose 50; D008925:Mites / Q000187:drug effects; D015394:Molecular Structure; D010938:Plant Oils / Q000737:chemistry; D013329:Structure-Activity Relationship; D055549:Volatile Organic Compounds / Q000032:analysis / Q000737:chemistry
chemical_list: C000590793:2-isopropyl-5-methylcyclohexanone; D056810:Acaricides; D003512:Cyclohexanones; D010938:Plant Oils; D055549:Volatile Organic Compounds