title: [Sick sinus syndrome possibly due to lopinavir-ritonavir: report of two cases].
abstract: We describe herein two cases of sick sinus syndrome possibly due to lopinavir-ritonavir in HIV-infected individuals. The heart rate dropped to 30 to 40 beats per minute in both cases, but patients remained asymptomatic and recovered promptly after discontinuation of lopinavir-ritonavir. The time until onset varied; one patient developed bradyarrhythmia 9 days after the initial dose, and another 4 hours after. Since lopinavir-ritonavir is a frequently used antiretroviral agent, clinicians must be aware of this potentially lethal adverse effect.
authors.affiliation: Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital.
authors.forename: Shugo
authors.initials: S
authors.lastname: Sasaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suganuma
authors.forename: Akifumi
authors.initials: A
authors.lastname: Imamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ajisawa
mesh_terms: D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D061466:Lopinavir / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000009:adverse effects*; D012804:Sick Sinus Syndrome / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D044966:Anti-Retroviral Agents; D061466:Lopinavir; D019438:Ritonavir