title: Otoacoustic emission sensitivity to exposure to styrene and noise.
abstract: The ototoxic effect of the exposure to styrene is evaluated, also in the presence of simultaneous exposure to noise, using otoacoustic emissions as biomarkers of mild cochlear damage. Transient-evoked and distortion product otoacoustic emissions were recorded and analyzed in a sample of workers (15 subjects) exposed to styrene and noise in a fiberglass manufacturing facility and in a control group of 13 non-exposed subjects. Individual exposure monitoring of the airborne styrene concentrations was performed, as well as biological monitoring, based on the urinary concentration of two styrene metabolites, the Mandelic and Phenylglyoxylic acids. Noise exposure was evaluated using wearable phonometers, and hearing loss with pure tone audiometry. Due to their different job tasks, one group of workers was exposed to high noise and low styrene levels, another group to higher styrene levels, close to the limit of 20 ppm, and to low noise levels. A significant negative correlation was found between the otoacoustic emission levels and the concentration of the styrene urinary metabolites. Otoacoustic emissions, and particularly distortion products, were able to discriminate the exposed workers from the controls, providing also a rough estimate of the slope of the dose-response relation between otoacoustic levels and styrene exposure.
authors.affiliation: Occupational Hygiene Department, INAIL Research, Monteporzio Catone (Roma), Italy.
authors.forename: R
authors.initials: R
authors.lastname: Sisto
authors.forename: L
authors.initials: L
authors.lastname: Cerini
authors.forename: M P
authors.initials: MP
authors.lastname: Gatto
authors.forename: M
authors.initials: M
authors.lastname: Gherardi
authors.forename: A
authors.initials: A
authors.lastname: Gordiani
authors.forename: F
authors.initials: F
authors.lastname: Sanjust
authors.forename: E
authors.initials: E
authors.lastname: Paci
authors.forename: G
authors.initials: G
authors.lastname: Tranfo
authors.forename: A
authors.initials: A
authors.lastname: Moleti
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000652:urine; D001301:Audiometry, Pure-Tone; D015415:Biomarkers / Q000652:urine; D001711:Biotransformation; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003051:Cochlea / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006317:Hearing Loss, Noise-Induced / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007587:Job Description; D008297:Male; D008875:Middle Aged; D009622:Noise / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects; D016272:Occupational Health; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D012463:Saliva / Q000378:metabolism; D020058:Styrene / Q000009:adverse effects* / Q000652:urine; D053719:Tandem Mass Spectrometry
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D020058:Styrene