title: Nizatidine Improves Impaired Salivary Secretion in GERD.
abstract: During esophageal acid clearance, salivation plays an important role in defending the esophageal mucosa. Nizatidine, a histamine H2 receptor antagonist, inhibits acetylcholine esterase, with a resultant increase in acetylcholine. We experienced a patient with gastroesophageal reflux disease (GERD) and impaired salivary secretion who has been successfully treated with nizatidine.
  
  
  METHODS
  A 63-year-old female visited our hospital with complaints of heartburn and continuous laryngeal discomfort. Saliva scintigraphy was performed to evaluate the salivary function. Washout ratio was decreased to be 25%-40% in individual salivary gland. After the treatment with nizatidine, salivary scintigraphy demonstrated the increased washout ratios. The values of both parotid glands increased up to 90%, whereas those of submandibular glands improved to be around a normal range. GERD symptoms disappeared completely after treatment. In conclusion, nizatidine may be one of therapeutic options for low salivary excretion.
authors.affiliation: Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan. Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan. Department of Hematology, Toho University, Tokyo, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Urita
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hike
authors.forename: Makie
authors.initials: M
authors.lastname: Nanami
authors.forename: Tadashi
authors.initials: T
authors.lastname: Maeda
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Asuka
authors.initials: A
authors.lastname: Nakayama
authors.forename: Takamasa
authors.initials: T
authors.lastname: Ishii
authors.forename: Kaoru
authors.initials: K
authors.lastname: Domon
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishihara
authors.forename: Masaki
authors.initials: M
authors.lastname: Sanaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakajima
authors.forename: Motonobu
authors.initials: M
authors.lastname: Sugimoto
keywords: GERD; laryngeal discomfort; nizatidine; salivary scintigraphy