title: Update on juvenile spondyloarthritis.
abstract: Spondyloarthritis (SpA) encompasses a group of disorders linked by overlapping clinical manifestations and genetic predisposition. Newer classification systems developed for adults with SpA focus on identifying individuals with axial or predominantly peripheral involvement. All forms of SpA can begin during childhood, and can be considered on a continuum with adult disease. Nevertheless, there are important differences in presentation and outcome that depend on age at onset. This article highlights these differences, what has been learned about genetics and pathogenesis of SpA, and important unmet needs for future studies.
authors.affiliation: Division of Rheumatology, Keck School of Medicine of USC, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, MS#60, Los Angeles, CA 90027, USA.
authors.forename: Anusha
authors.initials: A
authors.lastname: Ramanathan
authors.forename: Hemalatha
authors.initials: H
authors.lastname: Srinivasalu
authors.forename: Robert A
authors.initials: RA
authors.lastname: Colbert
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D016918:Arthritis, Reactive / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D002648:Child; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D058566:Sacroiliitis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D025242:Spondylarthropathies / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D018501:Antirheumatic Agents
keywords: Axial spondyloarthritis; Enthesitis-related arthritis; HLA-B27; Juvenile psoriatic arthritis; Juvenile spondyloarthritis