title: Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study.
abstract: OBJECTIVE
  To observe the improvement of functional dyspepsia (FD) after helicobacter pylori (HP) eradication in FD patients.
  
  
  METHODS
  644 FD patients were recruited of whom 585 completed follow up. They were divided into postprandial distress syndrome (PDS) group and epigastric pain syndrome (EPS) group. Patients with HP infection were randomly allocated into eradication group and non-eradication group. Patients in the eradication group were randomly assigned into two groups and treated with triple therapy and sequential therapy, respectively. Patients in non-eradication group and HP non-infection group were treated with Domperidone (PDS patients) or Talcid (EPS patients). Clinical symptoms were evaluated.
  
  
  RESULTS
  When compared with patients with unsuccessful HP eradication and without eradication, significant improvement in symptoms was found at 8 w, 12 w, and 26 w in patients with successful HP eradication in EPS group (P < 0.05). However, in PDS group, improvement in symptoms was comparable among patients expect at 26 w after successful HP eradication (P < 0.05). Therapeutic efficacy in patients without HP eradication was poorer than that in HP negative patients in EPS group (P < 0.05), while in PDS group, symptoms were relived at 26 w and 52 w (P < 0.05).
  
  
  CONCLUSIONS
  HP is one of pathogenic factors of FD and HP eradication may benefit FD patients, regardless therapeutic regimes, especially in EPS patients.
authors.affiliation: Division of Gastroenterology, Union Hospital of Tongji Medical college, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Sanping
authors.initials: S
authors.lastname: Xu
authors.forename: Xueming
authors.initials: X
authors.lastname: Wan
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zheng
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Song
authors.forename: Minghu
authors.initials: M
authors.lastname: Cheng
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Du
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Hou
keywords: Epigastric pain syndrome; functional dyspepsia; helicobacter pylori eradication; helicobacter pylori infection; postprandial distress syndrome; sequential-therapy; triple-therapy