title: Racial differences in the association of insulin-like growth factor pathway and colorectal adenoma risk.
abstract: OBJECTIVE
  Insulin resistance is believed to play an important role in the link between energy imbalance and colon carcinogenesis. Emerging evidence suggests that there are substantial racial differences in genetic and anthropometric influences on insulin-like growth factors (IGFs); however, few studies have examined racial differences in the associations of IGFs and colorectal adenoma, precursor lesions of colon cancer.
  
  
  METHODS
  We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study.
  
  
  RESULTS
  Caucasians have higher IGF-1 levels compared to African Americans; mean IGF-1 levels are 119.0 ng/ml (SD = 40.7) and 109.8 ng/ml (SD = 40.8), respectively, among cases (p = 0.02). Mean IGF-1 levels are also higher in Caucasian controls (122.9 ng/ml, SD = 41.2) versus African American controls (106.9, SD = 41.2), p = 0.001. We observed similar differences in IGFBP3 levels by race. Logistic regression models revealed a statistically significant association of IGF-1 with colorectal adenoma in African Americans only, with adjusted odds ratios (ORs) of 1.68 (95 % CI 1.06-2.68) and 1.68 (95 % CI 1.05-2.71), respectively, for the second and third tertiles as compared to the first tertile. One SNP (rs496601) in IGF1R was associated with adenomas in Caucasians only; the per allele adjusted OR is 0.73 (95 % CI 0.57-0.93). Similarly, one IGF2R SNP (rs3777404) was statistically significant in Caucasians; adjusted per allele OR is 1.53 (95 % CI 1.10-2.14).
  
  
  CONCLUSIONS
  Our results suggest racial differences in the associations of IGF pathway biomarkers and inherited genetic variance in the IGF pathway with risk of adenomas that warrant further study.
authors.affiliation: Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY, USA, hmochs2@buffalo.edu.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Ochs-Balcom
authors.forename: Caila B
authors.initials: CB
authors.lastname: Vaughn
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Chen
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Thompson
authors.forename: Niyati
authors.initials: N
authors.lastname: Parekh
authors.forename: Russell
authors.initials: R
authors.lastname: Tracy
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics / Q000378:metabolism; D001741:Black or African American / Q000235:genetics / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D009820:Ohio / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism*; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data*
chemical_list: D013002:Somatomedins