title: FHIT, EGFR, and MSH2: possible etiopathologic, prognostic, and predictive role in non-small cell lung carcinoma in Egyptian patients.
abstract: The high incidence and mortality of lung carcinoma in Egypt necessitates studying the factors that may be implicated in non-small cell lung carcinoma (NSCLC) pathogenesis and could affect patient management. The aim was to study FHIT, epidermal growth factor receptor (EGFR), and MSH2 protein expression in Egyptian patients with NSCLC. Immunohistochemical staining for FHIT, EGFR, and MSH2 was performed on 64 specimens from NSCLC patients and correlated with prognostic parameters, response to therapy, and overall survival. FHIT loss was observed in 64% of NSCLC patients and was significantly associated with SCC (P=0.003) and poor tumor grade (P=0.043). EGFR overexpression was observed in 47% of NSCLC patients and was significantly associated with SCC (P=0.002). MSH2 was reduced in 23.4% of NSCLC patients and was significantly associated with adenocarcinoma (P=0.024). In a univariate analysis, a significant relationship was seen between the poor overall survival in NSCLC patients and high T-stage (P=0.029), presence of metastasis (P=0.014), advanced-stage grouping (P=0.004), and FHIT loss (P=0.033). Further, FHIT loss was significantly related to disease progression in patients treated with chemotherapy (P=0.038). We conclude that all 3 markers play a role in the development of NSCLC in Egyptian patients. We suggest that FHIT loss be used as a predictor for progression in chemotherapy-treated NSCLC patients.
authors.affiliation: *Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia ‡Department of Pathology, National Cancer Institute, Cairo University, Giza, Egypt †Department of Pathology, School of Medicine, Stanford University, Stanford, CA.
authors.forename: Sheren F
authors.initials: SF
authors.lastname: Younes
authors.forename: Hayam A
authors.initials: HA
authors.lastname: Aiad
authors.forename: Nancy Y
authors.initials: NY
authors.lastname: Asaad
authors.forename: Mona A
authors.initials: MA
authors.lastname: Kandil
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Natkunam
authors.forename: Nadia M
authors.initials: NM
authors.lastname: Mokhtar
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000235:genetics*; D016019:Survival Analysis; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D051718:MutS Homolog 2 Protein; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase; C512478:EGFR protein, human; C497172:MSH2 protein, human