title: Effect of vanillin on lipid profile in a model of hyperlipidemia, a preliminary study.
abstract: To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant at 200 and 400 mg/kg doses compared to hyperlipidemic control. The results demonstrate that vanillin at a dose of 200 and 400 mg/kg body weight lowers the serum triglyceride, VLDL-C and total cholesterol level significantly in high fat diet induced hyperlipidemic rats. However there was no significant effect on the lipid profile at 100 mg/kg dose. There were no statistically significant changes in the HDL-C and LDL-C levels at any of the given doses.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore 575 001, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Belagali
authors.forename: Sheetal D
authors.initials: SD
authors.lastname: Ullal
authors.forename: Ahsan
authors.initials: A
authors.lastname: Shoeb
authors.forename: Vani
authors.initials: V
authors.lastname: Bhagwath
authors.forename: K
authors.initials: K
authors.lastname: Ramya
authors.forename: Rakshitha
authors.initials: R
authors.lastname: Maskeri
mesh_terms: D000821:Animal Feed; D000818:Animals; D000069059:Atorvastatin; D001547:Benzaldehydes / Q000378:metabolism* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats; D005260:Female; D005609:Free Radicals; D005786:Gene Expression Regulation; D006538:Heptanoic Acids / Q000494:pharmacology; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D010100:Oxygen / Q000737:chemistry; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D001547:Benzaldehydes; D004041:Dietary Fats; D005609:Free Radicals; D006538:Heptanoic Acids; D008055:Lipids; D011758:Pyrroles; D014280:Triglycerides; D002784:Cholesterol; D000069059:Atorvastatin; C100058:vanillin; D010100:Oxygen