title: Relationship of plasma cytokines and clinical biomarkers to memory performance in HIV.
abstract: Chronic systemic immune activation and inflammatory processes have been linked to brain dysfunction in medically stable HIV-infected people. We investigated the association between verbal memory performance and plasma concentrations of 13 cytokines measured using multiplexed bead array immunoassay in 74 HIV-seropositive individuals and 50 HIV-seronegative controls. Memory performance was positively related to levels of IL-8 and IFN-γ, and negatively related to IL-10 and IL-18 and to hepatitis C infection. Memory performance was not significantly related to HIV disease markers. The results indicate the importance of systemic immune and inflammatory markers to neurocognitive function in chronic and stable HIV disease.
authors.affiliation: Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Correia
authors.forename: Ronald
authors.initials: R
authors.lastname: Cohen
authors.forename: Assawin
authors.initials: A
authors.lastname: Gongvatana
authors.forename: Skye
authors.initials: S
authors.lastname: Ross
authors.forename: James
authors.initials: J
authors.lastname: Olchowski
authors.forename: Kathryn
authors.initials: K
authors.lastname: Devlin
authors.forename: Karen
authors.initials: K
authors.lastname: Tashima
authors.forename: Bradford
authors.initials: B
authors.lastname: Navia
authors.forename: Suzanne
authors.initials: S
authors.lastname: Delamonte
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D015704:CD4 Antigens / Q000097:blood; D018932:Chemokine CCL2 / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000821:virology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015704:CD4 Antigens; D018932:Chemokine CCL2; D016207:Cytokines
keywords: CART; Cytokines; HIV; HIV clinical markers; Hepatitis C; Memory