title: Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.
abstract: Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Cheng
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves; D018547:Plant Stems / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C011309:mezerein
keywords: Anti-HIV-1; Daphnane diterpenoids; Euphorbiaceae; Trigonostemon thyrsoideum; Trigothysoids A−P