title: Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients.
abstract: BACKGROUND
  Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atherosclerotic complications. Elevated CRP & TNF-α level in periodontitis patients have been reported by several groups. The present study was performed to determine whether presence of periodontitis and periodontal therapy could influence the serum levels of CRP & TNF-α in cardiovascular disease patients.
  
  
  METHODS
  Forty cardiovascular disease subjects participated in the study. They were classified into two groups. Group A (Control) where no periodontal treatment was given, Group B (Test) where periodontal treatment (scaling & root planing) was performed. Periodontal clinical parameters like OHI-S, probing pocket depth, were evaluated together with serum CRP, TNF-α, at baseline and reassessed after 8 weeks for all the subjects in both the groups.
  
  
  RESULTS
  The CRP & TNF-α levels in both the groups decreased but the decrease in the Group A was minimal and was not statistically significant (P > 0.05); whereas in Group B where periodontal therapy was performed, there was statistically significant decrease.
  
  
  CONCLUSIONS
  It can be concluded from the study that there can be a possible causal relationship between pathogenesis of periodontal disease and CVD as inferred from the statistical significant outcome in the form of decreased inflammatory biomarkers after the periodontal treatment.
authors.affiliation: Department of Periodontics, Sri Sai college of dental surgery, Vikarabad, AP, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Koppolu
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Durvasula
authors.forename: Rajababu
authors.initials: R
authors.lastname: Palaparthy
authors.forename: Mukhesh
authors.initials: M
authors.lastname: Rao
authors.forename: Vidya
authors.initials: V
authors.lastname: Sagar
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Reddy
authors.forename: Swapna
authors.initials: S
authors.lastname: Lingam
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology; D010518:Periodontitis / Q000097:blood / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: CRP; CVD; TNF-alpha; lipopolysaccharide; periodontitis