title: Chemokine profile in the sera and urine of patients with schistosomal glomerulopathy.
abstract: We investigated the serum and urine chemokine levels of patients with schistosomal mansoni glomerulonephritis. This cross-sectional study was conducted in the Southeast of Brazil. Overall, 160 subjects were enrolled and divided into five groups: 1) hepatosplenic schistosomiasis with renal disease (N = 12); 2) hepatosplenic schistosomiasis without renal disease (N = 68); 3) hepatointestinal schistosomiasis (N = 27); 4) glomerulopathy caused by other diseases (N = 22); and 5) healthy controls (N = 31). The patients with microalbuminuria > 30 mg in 24 hours were considered to have renal disease. The sera and urine chemokines CCL2, CCL3, CCL5, CCL11, and CXCL8 were measured using an enzyme-linked immunosorbent assay test. A similar profile was observed between the patients with schistosomal glomerulopathy and the patients with glomerulopathy caused by other diseases, with the exception of serum CCL2 ≤ 634.3 pg/mL. In cases with sera CCL2 > 634.3 pg/mL, the diagnosis of schistosomal glomerulopathy should be considered.
authors.affiliation: Department of Infectology and Tropical Medicine, Federal University of Minas Gerais, Brazil; Department of Imunology, Federal University of Minas Gerais, Brazil; Department of Epidemiology, Federal University of Minas Gerais, Brazil; Department of Nephrology, Federal University of Minas Gerais, Brazil.
authors.forename: Alba
authors.initials: A
authors.lastname: Otoni
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Izabela
authors.initials: I
authors.lastname: Voieta
authors.forename: Carlos Maurício
authors.initials: CM
authors.lastname: Antunes
authors.forename: Vinícius Lins
authors.initials: VL
authors.lastname: Costa Melo
authors.forename: Sandra Costa
authors.initials: SC
authors.lastname: Drummond
authors.forename: Valério Ladeira
authors.initials: VL
authors.lastname: Rodrigues
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Lambertucci
mesh_terms: D000328:Adult; D018925:Chemokines / Q000097:blood* / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D005921:Glomerulonephritis / Q000097:blood / Q000469:parasitology* / Q000473:pathology / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012552:Schistosomiasis / Q000097:blood* / Q000473:pathology / Q000652:urine*
chemical_list: D018925:Chemokines