title: Vitamin K status in chronic kidney disease.
abstract: The purpose of this review is to summarize the research to date on vitamin K status in chronic kidney disease (CKD). This review includes a summary of the data available on vitamin K status in patients across the spectrum of CKD as well as the link between vitamin K deficiency in CKD and bone dynamics, including mineralization and demineralization, as well as ectopic mineralization. It also describes two current clinical trials that are underway evaluating vitamin K treatment in CKD patients. These data may inform future clinical practice in this population.
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3V6, Canada. holdenr@kgh.kari.net.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: McCabe
authors.forename: Michael A
authors.initials: MA
authors.lastname: Adams
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Holden
mesh_terms: D015519:Bone Density; D001842:Bone and Bones; D003677:Deficiency Diseases / Q000097:blood / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D009752:Nutritional Status; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications*; D014812:Vitamin K / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014812:Vitamin K