title: Tapping the treasure of intracellular oncotargets with immunotherapy.
abstract: It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells.
authors.affiliation: Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
authors.forename: Cheng William
authors.initials: CW
authors.lastname: Hong
authors.affiliation: Institute of Molecular and Cell Biology, A(∗)STAR (Agency for Science, Technology and Research), Republic of Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore. Electronic address: mcbzengq@imcb.a-star.edu.sg.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D042541:Intracellular Space / Q000276:immunology*; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000628:therapy*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm
keywords: Antibody therapy; Cancer; Extracellular receptor; Immunotherapy; Intracellular oncotarget; Vaccination