title: [A case of melena and perforation during chemotherapy for peripheral T-cell lymphoma, not otherwise specified of the small intestine].
abstract: A 71-year-old male presented with gastrointestinal bleeding. Double-balloon endoscopy revealed diffuse thickening of the wall and a shallow ulcer measuring approximately 10cm in the mid jejunum. Biopsy revealed diffuse proliferation of large lymphoid cells that were immunohistochemically positive for CD3, CD5, and bcl-2 but negative for CK, CD10, CD20, and bcl-6. The cyclin D1 labeling index was 3% and the MIB-1 labeling index was 61%. On the basis of these findings, he was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) of the small intestine. Following four courses of THP-COP chemotherapy, he developed intestinal perforation and underwent partial resection of the small intestine. He is currently undergoing further chemotherapy.
authors.affiliation: Endoscopy Center, Aishinkai Nakae Hospital.
authors.forename: Konosuke
authors.initials: K
authors.lastname: Nakaji
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Nakae
authors.forename: Atsuyo
authors.initials: A
authors.lastname: Fujita
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Kumamoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications* / Q000188:drug therapy*; D007416:Intestinal Perforation / Q000209:etiology*; D007421:Intestine, Small; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008551:Melena / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone