title: Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis.
abstract: Teriflunomide is an oral disease-modifying therapy recently approved in several locations for relapsing-remitting multiple sclerosis. To gain insight into the effects of teriflunomide, immunocyte population changes were measured during progression of experimental autoimmune encephalomyelitis in Dark Agouti rats. Treatment with teriflunomide attenuated levels of spinal cord-infiltrating T cells, natural killer cells, macrophages, and neutrophils. Teriflunomide also mitigated the disease-induced changes in immune cell populations in the blood and spleen suggesting an inhibitory effect on pathogenic immune responses.
authors.affiliation: Inflammation and Immunology Translational Development, Celgene Corporation , Summit, NJ , USA.
authors.forename: Garth E
authors.initials: GE
authors.lastname: Ringheim
authors.forename: Lan
authors.initials: L
authors.lastname: Lee
authors.forename: Lynn
authors.initials: L
authors.lastname: Laws-Ricker
authors.forename: Tomas
authors.initials: T
authors.lastname: Delohery
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Donghui
authors.initials: D
authors.lastname: Zhang
authors.forename: Nicholas
authors.initials: N
authors.lastname: Colletti
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Soos
authors.forename: Kendra
authors.initials: K
authors.lastname: Schroeder
authors.forename: Barbara
authors.initials: B
authors.lastname: Fanelli
authors.forename: Nian
authors.initials: N
authors.lastname: Tian
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Arendt
authors.forename: Deborah
authors.initials: D
authors.lastname: Iglesias-Bregna
authors.forename: Margaret
authors.initials: M
authors.lastname: Petty
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Ji
authors.forename: George
authors.initials: G
authors.lastname: Qian
authors.forename: Rajula
authors.initials: R
authors.lastname: Gaur
authors.forename: Daniel
authors.initials: D
authors.lastname: Weinstock
authors.forename: Jean
authors.initials: J
authors.lastname: Cavallo
authors.forename: Juventas
authors.initials: J
authors.lastname: Telsinskas
authors.forename: Kathleen
authors.initials: K
authors.lastname: McMonagle-Strucko
keywords: dihydro-orotate dehydrogenase; experimental autoimmune encephalomyelitis; lymphocytes; multiple sclerosis; teriflunomide