title: An unusual form of Naxos disease and its improvement by adjuvant low-dose colchicine therapy.
abstract: We evaluated a female patient with an unusual form of Naxos disease, who presented with central cyanosis and clubbing, simulating congenital heart disease. Adjuvant low-dose colchicine therapy (0.5 mg once daily) showed positive effects and has been continued for six months. Colchicine has anti-inflammatory and anti-fibrotic properties. It inhibits mitosis by disrupting tubulin assembly and enhances cellular apoptosis. Follow-up showed improvement in the patient's clinical status, with a dramatic disappearance of the electrical storm and reductions in cyanosis and palmoplantar hyperkeratosis. Low-dose colchicine may be safe and effective in patients with Naxos disease and may reduce related complications.
authors.affiliation: Dept. of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey. nngultekin@yahoo.com
authors.forename: Nazmi
authors.initials: N
authors.lastname: Gultekin
authors.forename: Emine
authors.initials: E
authors.lastname: Kucukates
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D003078:Colchicine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006201:Hair Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008790:Metoprolol / Q000008:administration & dosage; D008875:Middle Aged; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000008:administration & dosage
chemical_list: D000889:Anti-Arrhythmia Agents; D050257:Tubulin Modulators; D008790:Metoprolol; D003078:Colchicine