title: The association study of plasma levels of pigment epithelium-derived factor with acute coronary syndrome in the chinese han population.
abstract: OBJECTIVE
  To investigate the relationship between plasma levels of pigment epithelium-derived factor (PEDF) and acute coronary syndrome (ACS) in the Chinese Han population.
  
  
  METHODS
  Plasma PEDF levels were measured in 200 consecutive ACS patients and 160 age- and sex-matched healthy control subjects. Logistic regression analysis was performed to determine whether PEDF was an independently protective factor against ACS. All ACS patients were followed up for 6 months and the short-term major adverse cardiovascular events (MACE) were obtained: cardiac death and recurrent angina.
  
  
  RESULTS
  The ACS patients showed notably lower plasma PEDF levels relative to the control group (7.31 ± 2.21 vs. 8.44 ± 2.13 μg/ml, respectively, p = 0.001). Logistic regression analysis revealed that PEDF had a significant protective effect against ACS (OR = 0.76, 95% CI 0.623-0.935, p = 0.01). After 6 months of follow-up, we found that the mean PEDF concentration of the patients with short-term MACE was lower than the patients without (6.05 ± 2.18 vs. 7.52 ± 2.07 µg/ml, p = 0.031). The Kaplan-Meier survival curves suggested that patients with plasma PEDF levels <7.00 µg/ml showed a lower survival trend than those in the higher group, but the difference was not significant (p = 0.477).
  
  
  CONCLUSIONS
  Our study indicates that plasma PEDF levels are significantly lower in ACS patients than in controls, and lower PEDF levels are further associated with adverse cardiac outcomes after ACS.
authors.affiliation: Cardiovascular Department, Chinese PLA General Hospital, Beijing, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.forename: Jinxin
authors.initials: J
authors.lastname: Shi
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Tao
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000208:ethnology / Q000401:mortality; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D015843:Serpins / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor