title: [Urinary L-type fatty acid binding protein (L-FABP) as a new urinary biomarker promulgated by the Ministry of Health, Labour and Welfare in Japan].
abstract: Liver-type fatty acid binding protein (L-FABP) is a 14kDa protein found in the cytoplasm of human renal proximal tubules. Fatty acids are bound with L-FABP and transported to the mitochondria or peroxisomes, where fatty acids are beta-oxidized, and this may play a role in fatty acid homeostasis. Moreover, L-FABP has high affinity and capacity to bind long-chain fatty acid oxidation products, and may be an effective endogenous antioxidant. Renal L-FABP is rarely expressed in the kidneys of rodents. In order to evaluate the pathological dynamics of renal L-FABP in kidney disease, human L-FABP chromosomal transgenic mice were generated. Various stress, such as massive proteinuria, hyperglycemia, hypertension, and toxins overloaded in the proximal tubules were revealed to up-regulate the gene expression of renal L-FABP and increase the excretion of L-FABP derived from the proximal tubules into urine. In clinical studies of chronic kidney disease (CKD), urinary L-FABP accurately reflected the degree of tubulointerstitial damage and correlated with the rate of CKD progression. Furthermore, a multicenter trial has shown that urinary L-FABP is more sensitive than urinary protein in predicting the progression of CKD. With respect to diabetic nephropathy and acute kidney disease (AKI), urinary L-FABP is an early diagnostic of kidney disease or a predictive marker for renal prognosis. After many clinical studies, urinary L-FABP was approved as a new tubular biomarker promulgated by the Ministry of Health, Labour and Welfare in Japan.
authors.affiliation: Department of Nephrology and Hypertension, St. Marianna University School of Medicine, Kawasaki 261-8511, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kamijo-Ikemori
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Katsuomi
authors.initials: K
authors.lastname: Matsui
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugaya
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000191:economics / Q000628:therapy; D015415:Biomarkers / Q000652:urine*; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D006801:Humans; D007348:Insurance, Health; D007564:Japan; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000191:economics / Q000628:therapy; D011507:Proteinuria / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins