title: Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients.
abstract: OBJECTIVE
  Bariatric surgery is an efficient procedure for the remission of type 2 diabetes (T2DM) from morbid obesity. However, in Asian countries, the mean body mass index (BMI) of T2DM patients is about 25 kg/m(2). Various data on patients undergoing gastric bypass surgery suggest that the control of T2DM after surgery occurs rapidly. We hypothesized that even in nonobese patients with T2DM, the levels of incretin and insulin changed along with the improvement of T2DM as a consequence of the gastric bypass.
  
  
  METHODS
  From March to December 2011, 12 nonobese patients (mean BMI; 26.2 kg/m(2)) with poorly-controlled [mean glycated hemoglobin (HbA1C); 9.5%] diabetes underwent gastric bypass surgery. Values related to diabetes, including incretin [gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1)] levels were measured before and 1 month after surgery. All values were measured in response to a 75 g oral glucose tolerance test (OGTT).
  
  
  RESULTS
  On average, the BMI decreased by 2.1 ± 0.7 kg/m(2). Mean HbA1C level decreased by 1.6 ± 2%. Oral glucose-stimulated insulin levels increased and GLP-1 levels also increased significantly. Oral glucose-stimulated GIP levels decreased sharply.
  
  
  CONCLUSIONS
  Soon after gastric bypass in nonobese T2DM patients, control of T2DM is achieved. The incretin release after oral glucose is improved. This could be a consequence of changes of the enteroinsular axis, particularly in the incretins.
authors.affiliation: Department of Surgery, Soonchunhyang University College of Medicine, Seoul, South Korea.
authors.forename: Myung Jin
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South Korea.
authors.forename: Hyeong Kyu
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South Korea.
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Byun
authors.affiliation: Department of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South Korea.
authors.forename: Kyo Il
authors.initials: KI
authors.lastname: Suh
authors.affiliation: Department of Surgery, Soonchunhyang University College of Medicine, Seoul, South Korea. Electronic address: hurusa@hanmail.net.
authors.forename: Kyung Yul
authors.initials: KY
authors.lastname: Hur
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D006801:Humans; D054795:Incretins / Q000097:blood*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged
chemical_list: D054795:Incretins
keywords: gastric bypass; incretin; metabolic surgery; type 2 diabetes mellitus