title: Salidroside liposome formulation enhances the activity of dendritic cells and immune responses.
abstract: Salidroside, the important composition, of Rhodiola rosea L. has been reported to have various pharmacological properties. Liposome is known to be effective as drug carriers and immune adjuvant. Therefore, the aim of this study is to investigate immunological adjuvant activity of salidroside liposome. Here we reported the preparation, the effect on DCs in vitro and the immune response in vivo. The immunological adjuvant activity of salidroside liposome formulation was compared with that of salidroside and liposome. The result showed that salidroside liposome formulation not only could promote the maturation of DCs, the stimulation of DCs on MLR proliferation and the antigen presenting ability, but also induced the sustained cellular immune and humoral immune response. Overall, the results showed that salidroside liposome formulation had the potential to act as effective sustained release vaccine delivery systems.
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China; National Research Center of Veterinary Biologicals Engineering and Technology, Jiangsu Academy of Agricultural Science, Nanjing 210014, PR China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Tao
authors.forename: Yee
authors.initials: Y
authors.lastname: Huang
authors.forename: Deyun
authors.initials: D
authors.lastname: Wang
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Hu
authors.forename: Jiaguo
authors.initials: J
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Yu
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003692:Delayed-Action Preparations; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D005260:Female; D005960:Glucosides / Q000008:administration & dosage*; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008081:Liposomes; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010636:Phenols / Q000008:administration & dosage*; D013154:Spleen / Q000166:cytology
chemical_list: D000276:Adjuvants, Immunologic; D000485:Allergens; D003692:Delayed-Action Preparations; D005960:Glucosides; D007074:Immunoglobulin G; D007376:Interleukin-2; D008081:Liposomes; D010636:Phenols; D007371:Interferon-gamma; D010047:Ovalbumin; C009172:rhodioloside
keywords: Adjuvant; Dendritic cells; OVA; Salidroside liposomes; Vaccine