title: Central nervous system vasculitis associated with hepatitis C virus infection: a brain MRI-supported diagnosis.
abstract: BACKGROUND
  The Hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, being the Central Nervous System (CNS) rarely involved.
  
  
  METHODS
  We report a case of a 54 year-old black man with arterial hypertension who presented with progressively worsening headaches, apathy, somnolence and left hemiparesis. Brain MRI showed an acute ischemic lesion in the left anterior cerebral artery (ACA) and an old ischemic infarct in the right ACA territory. Brain MRI with gadolinium revealed mural thickening and contrast enhancement of the A1 and A2 segments of the ACAs, of the middle and distal basilar artery and of the P1 segment of the left posterior cerebral artery, suggesting active vasculitis. Digital angiography confirmed those irregularities and stenosis. Laboratory evaluation revealed ESR (73 mm/h), transaminase elevation, elevated HCV viral load genotype 2, positive IGRA, negative cryoglobulins, CSF protein elevation with oligoclonal bands (mirror pattern) and no pleocytosis; investigation excluded other infectious causes. Pegylated interferon alpha-2a and ribavirin, corticotherapy and tuberculosis prophylaxis were started with clinical and imagiological improvement.
  
  
  CONCLUSIONS
  The typical inflammation signs of the vascular wall demonstrated by the gadolinium-enhanced MRI strengthened the hypothesis of CNS vasculitis. The association with HCV infection is rare but should be investigated once specific therapeutic is required.
authors.affiliation: Department of Neurosciences, Stroke Unit, Hospital de Santa Maria, Portugal. Electronic address: ana_palmela@msn.com.
authors.forename: A
authors.initials: A
authors.lastname: Castro Caldas
authors.affiliation: Department of Neurosciences, Stroke Unit, Hospital de Santa Maria, Portugal; University of Lisbon, Lisbon, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Geraldes
authors.affiliation: Department of Neurosciences, Stroke Unit, Hospital de Santa Maria, Portugal; University of Lisbon, Lisbon, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Neto
authors.affiliation: Department of Neurosciences, Stroke Unit, Hospital de Santa Maria, Portugal; University of Lisbon, Lisbon, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Canhão
authors.affiliation: Department of Neurosciences, Stroke Unit, Hospital de Santa Maria, Portugal; University of Lisbon, Lisbon, Portugal.
authors.forename: T P
authors.initials: TP
authors.lastname: Melo
mesh_terms: D001921:Brain / Q000473:pathology* / Q000821:virology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020293:Vasculitis, Central Nervous System / Q000150:complications* / Q000175:diagnosis*
keywords: CNS vasculitis; Gadolinium MRI; Gadolinium enhanced blood vessels; HCV infection; Steroid treatment; Stroke