title: Clean and efficient synthesis of isoxazole derivatives in aqueous media.
abstract: A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
authors.affiliation: School of Safety Engineering, China University of Mining & Technology, Xuzhou 221116, China. gldoucumt@163.com.
authors.forename: Guolan
authors.initials: G
authors.lastname: Dou
authors.forename: Pan
authors.initials: P
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Yukun
authors.initials: Y
authors.lastname: Xi
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
mesh_terms: D019811:Hydroxylamine / Q000737:chemistry; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D014867:Water
chemical_list: D007555:Isoxazoles; D014867:Water; D019811:Hydroxylamine