title: Pharmacology of carbon nanotubes: toxicokinetics, excretion and tissue accumulation.
abstract: Carbon nanotubes (CNT) are increasingly being investigated for their use in biomedical applications and nanomedicine. An emergent need for the understanding of their in vivo biodistribution and pharmacokinetics is therefore needed to establish the essential properties and criteria for their further development as targeted CNT delivery systems to specific tissues for diagnostics and therapeutic purposes. Until their biodistribution and toxicoketic profiles are fully understood, their translation into the clinic will be hindered. This review will highlight the important factors affecting the biodistribution and pharmacokinetic profile of CNT and address their toxicokinetics following systemic, pulmonary and dermal exposure.
authors.affiliation: Pharmacy, Pharmacology and Therapeutics, School of Clinical and Experimental Medicine, Medical School, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Hanene
authors.initials: H
authors.lastname: Ali-Boucetta
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
mesh_terms: D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism; D050997:Nanomedicine / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D010599:Pharmacokinetics; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D037742:Nanotubes, Carbon
keywords: Biodistribution; CNT; Carbon nanotubes; Functionalisation; Nanotoxicology; Toxicokinetics