title: Interictal serum S-100B protein levels in intractable epilepsy: a case-control study.
abstract: Epilepsy is the most common neurologic disorder of childhood. In approximately 6-14% of all patients with epilepsy, complete seizure control is difficult to achieve with current antiepileptic treatments. Several current studies have shown in both animals and people that the lengthening of epileptic seizures and frequent recurrence increases the likelihood of neuronal damage. S-100B protein is the most analyzed brain derived peripheral biochemical marker in brain damage. This study aimed to evaluate interictal serum S-100B protein levels in children diagnosed with intractable epilepsy. A group of 32 patients with intractable epilepsy and 25 healthy controls were recruited. Serum S-100B protein levels were measured using a commercially available electrochemiluminescence immunoassay (ECLIA kit, as supplied and according to the manufacturer's standards. The serum S-100B protein levels of the patient group in the study were found to be 0.094±0.011 μm/L, and 0.083±0.014 μm/L in the age-matched control group. The difference between the groups was determined to be statistically significant (P=0.004). In conclusions, it can be said that as the serum S-100B protein levels of the patients with focal epilepsy were high compared to those of the control group, this can be reliable peripheral biomarker for neuronal damage in patients with focal intractable epilepsy.
authors.affiliation: Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey. Electronic address: m.calik80@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calik
authors.affiliation: Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Abuhandan
authors.affiliation: Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.affiliation: Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Güzel
authors.affiliation: Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Solmaz
authors.affiliation: Department of Clinical Fizyology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.affiliation: Department of Pediatric Neurology, BezmialemVakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Akin
authors.initials: A
authors.lastname: Iscan
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D004827:Epilepsy / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D017211:Treatment Failure
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit
keywords: Biomarker; Childhood; Focal intractable epilepsy; S-100B