title: Simultaneous electrochemical determination of dopamine and paracetamol on multiwalled carbon nanotubes/graphene oxide nanocomposite-modified glassy carbon electrode.
abstract: In the present study, multiwalled carbon nanotubes (MWCNT)/graphene oxide (GO) nanocomposite was prepared by homogenous dispersion of MWCNT and GO and used for the simultaneous voltammetric determination of dopamine (DA) and paracetamol (PA). The TEM results confirmed that MWCNT walls were wrapped well with GO sheets. The MWCNT/GO nanocomposite showed superior electrocatalytic activity towards the oxidation of DA and PA, when compared with either pristine MWCNT or GO. The major reason for the efficient simultaneous detection of DA and PA at nanocomposite was the synergistic effect between MWCNT and GO. The electrochemical oxidation of DA and PA was investigated by cyclic voltammetry, differential pulse voltammetry and amperometry. The nanocomposite modified electrode showed electrocatalytic oxidation of DA and PA in the linear response range from 0.2 to 400 µmol L(-1) and 0.5 to 400 µmol L(-1) with the detection limit of 22 nmol L(-1) and 47 nmol L(-1) respectively. The proposed sensor displayed good selectivity, sensitivity, stability with appreciable consistency and precision.
authors.affiliation: Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, |No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Cheemalapati
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Palanisamy
authors.forename: Veerappan
authors.initials: V
authors.lastname: Mani
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Chen
mesh_terms: D000082:Acetaminophen / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008297:Male; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides; D015203:Reproducibility of Results
chemical_list: D037742:Nanotubes, Carbon; D010087:Oxides; D000082:Acetaminophen; D006108:Graphite; D004298:Dopamine
keywords: Dopamine; Electrochemical determination; Graphene oxide–multi-walled carbon nanotubes nanocomposite; Paracetamol