title: [Effect of acupuncture on pattern-visual evoked potential in rats with monocular visual deprivation].
abstract: OBJECTIVE
  To explore electrophysiology mechanism of acupuncture for treatment and prevention of visual deprivation effect.
  
  
  METHODS
  Eighteen healthy 15-day Evans rats were randomly divided into a normal group, a model group and an acupuncture group, 6 rats in each one. Deprivation amblyopia model was established by monocular eyelid suture in the model group and acupuncture group. Acupuncture was applied at "Jingming" (BL 1), "Chengqi" (ST 1), "Qiuhou" (EX-HN 7) and "Cuanzhu" (BL 2) in the acupuncture group. The bilateral acupoints were selected alternately, one side for a day, and totally 14 days were required. The effect of acupuncture on visual evoked potential in different spatial frequencies was observed.
  
  
  METHODS
  Under three different kinds of spatial frequencies of 2 X 2, 4 X 4 and 8 X 8, compared with normal group, there was obvious visual deprivation effect in the model group where P1 peak latency was delayed (P<0.01) while N1 -P1 amplitude value was decreased (P<0.01). Compared with model group, P1 peak latency was obviously ahead of time (P<0.01) while N1-P1 amplitude value was increased (P<0.01) in the acupuncture group, there was no statistical significance compared with normal group (P>0.05). Under spatial frequency of 4 X 4, N1-P1 amplitude value was maximum in the normal group and acupuncture group. With this spatial frequency the rat's eye had best resolving ability, indicating it could be the best spatial frequency for rat visual system.
  
  
  CONCLUSIONS
  The visual system has obvious electrophysiology plasticity in sensitive period. Acupuncture treatment could adjust visual deprivation-induced suppression and slow of visual response in order to antagonism deprivation effect.
authors.affiliation: Department of Acupuncture, Moxibustion and Tuina, Gansu University of TCM, Lanzhou 730000, China. yanxingke@126.com
authors.forename: Xing-Ke
authors.initials: XK
authors.lastname: Yan
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Dong
authors.forename: An-Guo
authors.initials: AG
authors.lastname: Liu
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Wang
authors.forename: Chong-Bing
authors.initials: CB
authors.lastname: Ma
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Zhu
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000550:Amblyopia / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans