title: One pot synthesis of bioactive benzopyranones through palladium-catalyzed C-H activation and CO insertion into 2-arylphenols.
abstract: Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30010, Taiwan, R.O.C.. jscchuang@faculty.nctu.edu.tw.
authors.forename: Tai-Hua
authors.initials: TH
authors.lastname: Lee
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Jayakumar
authors.forename: Chien-Hong
authors.initials: CH
authors.lastname: Cheng
authors.forename: Shih-Ching
authors.initials: SC
authors.lastname: Chuang
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D019800:Phenol / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D019800:Phenol; D010165:Palladium; D002248:Carbon Monoxide