title: Depression and Parkinson's disease: current knowledge.
abstract: Depressive disturbances are common in patients with Parkinson's disease (PD) and influence many other clinical aspects of the disease. In addition to causing inherent emotional distress, depressive disorders negatively impact quality of life, motor and cognitive deficits, functional disability, and other psychiatric comorbidities in patients with PD. Knowledge of the pathophysiology of PD depression remains limited. However, clinical studies demonstrate the efficacy of medications and psychotherapies for PD depression, underscoring the importance of their timely detection and concerted management.
authors.affiliation: Baylor College of Medicine, Departments of Psychiatry and Neurology, Michael E. DeBakey Veterans Affairs Medical Center, Mental Health Care Line (116), 2002 Holcombe Boulevard, Houston, TX, 77030, USA, laura.marsh2@va.gov.
authors.forename: Laura
authors.initials: L
authors.lastname: Marsh
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001521:Behavior Therapy; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy
chemical_list: D000928:Antidepressive Agents