title: Provocative testing for coronary reactivity and spasm.
abstract: Coronary spasm is an important and often overlooked etiology of chest pain. Although coronary spasm, or Prinzmetal's angina, has been thought of as benign, contemporary studies have shown serious associated adverse outcomes, including acute coronary syndrome, arrhythmia, and death. Definitive diagnosis of coronary spasm can at times be difficult, given the transience of symptoms. Numerous agents have been historically described for provocative testing. We provide a review of published data for the role of provocation testing in the diagnosis of coronary spasm.
authors.affiliation: Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California.
authors.forename: Melody
authors.initials: M
authors.lastname: Zaya
authors.affiliation: Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California.
authors.forename: Puja K
authors.initials: PK
authors.lastname: Mehta
authors.affiliation: Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California. Electronic address: merz@cshs.org.
authors.forename: C Noel Bairey
authors.initials: CN
authors.lastname: Merz
mesh_terms: D000109:Acetylcholine; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology*; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005080:Exercise Test / Q000379:methods*; D006801:Humans; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D000109:Acetylcholine
keywords: ACH; CFR; CS; ER; IC; IV; MI; Prinzmetal's angina; SCA; acetylcholine; coronary flow reserve; coronary spasm; ergonovine; intracoronary; intravenous; myocardial infarction; provocation testing; sudden cardiac arrest