title: Clinical characteristics indicating adenomyosis coexisting with leiomyomas: a retrospective, questionnaire-based study.
abstract: OBJECTIVE
  To elucidate the clinical profile of a concomitant diagnosis of adenomyosis in women with leiomyomas.
  
  
  METHODS
  Retrospective questionnaire-based study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  The study sample comprised a total of 560 women: 159 women with adenomyosis and leiomyomas and 401 women with leiomyomas alone.
  
  
  METHODS
  Mailing of a symptom questionnaire.
  
  
  METHODS
  Comparison of women undergoing hysterectomy with adenomyosis and leiomyomas and women with leiomyomas alone.
  
  
  RESULTS
  Women with a concomitant diagnosis of adenomyosis and leiomyomas had significantly higher scores for disease burden during the menstrual period before surgery: heavy bleeding episodes and passing blood clots. Furthermore, women with adenomyosis and leiomyomas reported higher scores of distress regarding pelvic pain occurring during the menstrual period and pelvic pain not associated with the menstrual cycle. Moreover, in multivariate analysis, older age (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.18), gravidity (OR 1.44, 95% CI 1.12-1.74), and pelvic pain occurring during the menstrual period (OR 1.27, 95% CI 1.06-1.54) increase the odds of having adenomyosis and not only leiomyomas.
  
  
  CONCLUSIONS
  Adenomyosis contributes to symptomatology in women with concomitant adenomyosis and leiomyomas.
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany.
authors.forename: Sara Y
authors.initials: SY
authors.lastname: Brucker
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Huebner
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Heidelberg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Wallwiener
authors.affiliation: Department of Obstetrics and Gynecology and Surgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Ebersoll
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany.
authors.forename: Birgitt
authors.initials: B
authors.lastname: Schoenfisch
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany. Electronic address: florin-andrei.taran@med.uni-tuebingen.de.
authors.forename: Florin A
authors.initials: FA
authors.lastname: Taran
mesh_terms: D062788:Adenomyosis / Q000175:diagnosis* / Q000453:epidemiology*; D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000453:epidemiology*; D008875:Middle Aged; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*
keywords: Adenomyosis; symptom questionnaire; uterine leiomyomas