title: Decreased CD1a(+) , CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients.
abstract: OBJECTIVE
  The purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients.
  
  
  RESULTS
  Factor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P < 0.001), CD1a(+) cells (P < 0.05) and CD83(+) cells (P < 0.001) in cervical LNs and PTs compared to the non-AIDS control group.
  
  
  CONCLUSIONS
  Overall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control.
authors.affiliation: Department of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Rogério
authors.initials: R
authors.lastname: Gondak
authors.forename: Thais
authors.initials: T
authors.lastname: Mauad
authors.forename: Luciana
authors.initials: L
authors.lastname: Schultz
authors.forename: Fernando
authors.initials: F
authors.lastname: Soares
authors.forename: Luiz P
authors.initials: LP
authors.lastname: Kowalski
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Vargas
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D018949:Antigens, CD1 / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D026122:Factor XIIIa / Q000378:metabolism*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009333:Neck; D014066:Palatine Tonsil / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D026122:Factor XIIIa; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen; C419393:CD1a antigen
keywords: AIDS; dendritic cell; immunohistochemistry; lymph node; palatine tonsil