title: Risk factors for new-onset late postpartum preeclampsia in women without a history of preeclampsia.
abstract: OBJECTIVE
  Risk factors for the development of new-onset late postpartum preeclampsia (LPP) in women without any history of preeclampsia are not known. Because identification of women who are at risk may lead to an earlier diagnosis of disease and improved maternal outcomes, this study identified risk factors (associated patient characteristics) for new-onset LPP.
  
  
  METHODS
  A case-control study of 34 women with new-onset LPP and 68 women without new-onset LPP after normal delivery, who were matched on date of delivery, was conducted at Mount Sinai Hospital, New York, NY. Data were collected by chart review. Exact conditional logistic regression identified patient characteristics that were associated with new-onset LPP.
  
  
  RESULTS
  New-onset LPP was associated with age ≥40 years (adjusted odds ratio, 24.83; 95% confidence interval [CI], 1.43-infinity; P = .03), black race (adjusted odds ratio, 78.35; 95% CI, 7.25-infinity; P < .001), Latino ethnicity (adjusted odds ratio, 19.08; 95% CI, 2.73-infinity; P = .001), final pregnancy body mass index of ≥30 kg/m(2) (adjusted odds ratio, 13.38; 95% CI, 1.87-infinity; P = .01), and gestational diabetes mellitus (adjusted odds ratio, 72.91; 95% CI, 5.52-infinity; P < .001). As predictive tests for new-onset LPP, the sensitivity and specificity of having ≥1 of these characteristics was 100% and 59%, respectively, and the sensitivity and specificity of having ≥2 was 56% and 93%, respectively.
  
  
  CONCLUSIONS
  Older age, black race, Latino ethnicity, obesity, and a pregnancy complicated by gestational diabetes mellitus all are associated positively with the development of new-onset LPP. Closer observation may be warranted in these populations.
authors.affiliation: Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Bigelow
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Guilherme A
authors.initials: GA
authors.lastname: Pereira
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Amber
authors.initials: A
authors.lastname: Warmsley
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cohen
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Chloe
authors.initials: C
authors.lastname: Getrajdman
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Erin
authors.initials: E
authors.lastname: Moshier
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Julia
authors.initials: J
authors.lastname: Paris
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Angela
authors.initials: A
authors.lastname: Bianco
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY; Division of Infectious Disease, Department of Medicine, Mount Sinai School of Medicine, New York, NY.
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Factor
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY.
authors.forename: Joanne
authors.initials: J
authors.lastname: Stone
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D008423:Maternal Age; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D010359:Patient Readmission; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011644:Puerperal Disorders / Q000453:epidemiology*; D044469:Racial Groups / Q000706:statistics & numerical data; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
keywords: anticipatory guidance; new-onset late postpartum preeclampsia; postpartum eclampsia; preeclampsia; risk factor