title: Exercise-induced interstitial pulmonary edema at sea-level in young and old healthy humans.
abstract: We asked whether aged adults are more susceptible to exercise-induced pulmonary edema relative to younger individuals. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (Dm) and pulmonary-capillary blood volume (Vc) were measured before and after exhaustive discontinuous incremental exercise in 10 young (YNG; 27±3 years) and 10 old (OLD; 69±5 years) males. In YNG subjects, Dm increased (11±7%, P=0.031), Vc decreased (-10±9%, P=0.01) and DLCO was unchanged (30.5±4.1 vs. 29.7±2.9mL/min/mmHg, P=0.44) pre- to post-exercise. In OLD subjects, DLCO and Dm increased (11±14%, P=0.042; 16±14%, P=0.025) but Vc was unchanged (58±23 vs. 56±23mL, P=0.570) pre- to post-exercise. Group-mean Dm/Vc was greater after vs. before exercise in the YNG and OLD subjects. However, Dm/Vc was lower post-exercise in 2 of the 10 YNG (-7±4%) and 2 of the 10 OLD subjects (-10±5%). These data suggest that exercise decreases interstitial lung fluid in most YNG and OLD subjects, with a small number exhibiting evidence for exercise-induced pulmonary edema.
authors.affiliation: Cardiorespiratory Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic & Foundation, Rochester, MN 55905, USA. Electronic address: taylor.bryan@mayo.edu.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Taylor
authors.affiliation: Cardiorespiratory Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic & Foundation, Rochester, MN 55905, USA.
authors.forename: Alex R
authors.initials: AR
authors.lastname: Carlson
authors.affiliation: Cardiorespiratory Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic & Foundation, Rochester, MN 55905, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
authors.affiliation: Cardiorespiratory Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic & Foundation, Rochester, MN 55905, USA.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002199:Capillary Permeability; D016552:Ergometry; D015444:Exercise; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000473:pathology*; D011653:Pulmonary Diffusing Capacity / Q000379:methods; D011654:Pulmonary Edema / Q000209:etiology*; D011659:Pulmonary Gas Exchange; D055815:Young Adult
keywords: Aged adults; Alveolar–capillary membrane conductance; Lung fluid