title: [Fertility and cancer].
abstract: Information about chemo and/or radiotherapy gonadotoxicity and about fertility preservation is essential. Sperm cryopreservation has to be systematically offered before gonadotoxic treatments. Efficiency of ovarian function preservation with GnRH agonists is still debated. A controlled ovarian stimulation is necessary before oocyte or embryo cryopreservation. It is only feasible if the treatment is not urgent and if the tumor is not hormone-sensitive. If the treatment is highly gonadotoxic, an ovarian tissue cryopreservation may be appropriate. It is the only fertility preservation technique feasible for prepubertal girls. It is now possible to preserve the fertility of prepubertal boys by cryopreservation of testicular tissue. It is essential to send patients and/or their parents to a specialized fertility preservation center.
authors.affiliation: Hôpital Tenon, AP-HP, service d'histologie à orientation biologie de la reproduction, CECOS, 75020 Paris, France; Université Pierre-et-Marie-Curie, UPMC, Paris VI, 75005 Paris, France. Electronic address: catherine.poirot@tnn.aphp.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Poirot
authors.forename: Leslie
authors.initials: L
authors.lastname: Sitbon
authors.forename: Anne
authors.initials: A
authors.lastname: Fortin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berthaut
authors.forename: Suha
authors.initials: S
authors.lastname: Jaudi
authors.forename: Amandine
authors.initials: A
authors.lastname: Anastacio
authors.forename: Marie
authors.initials: M
authors.lastname: Prades
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D015925:Cryopreservation; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006080:Ovarian Follicle / Q000187:drug effects / Q000528:radiation effects; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D010063:Ovum; D013079:Sperm Maturation; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects; D013093:Spermatogonia / Q000637:transplantation; D013737:Testis / Q000637:transplantation; D055815:Young Adult