title: Correlations between F-18 FDG PET/CT and pathological findings in soft tissue lesions.
abstract: OBJECTIVE
  To evaluate the correlations between F-18 FDG uptake imaged with PET/CT and pathological findings in soft tissue lesions.
  
  
  METHODS
  Fifty-four soft tissue lesions in 47 patients were evaluated. The correlations between the degree of FDG uptake, pathological type and grade, and MRI signal intensity and/or enhancement pattern were evaluated. Tumor FDG uptake was quantified by the maximum standardized uptake value (SUVmax).
  
  
  RESULTS
  Thirty-one lesions were malignant and twenty-three lesions were benign. The difference between SUVmax in the malignant and benign groups was statistically significant (p<0.001). Malignant myxoid lesions and well differentiated liposarcoma showed low FDG uptake. Benign neurogenic lesions showed low FDG uptake while malignant neurogenic tumors showed high FDG uptake, and the difference between SUVmax in the benign and malignant lesions was statistically significant (p<0.001). In a neurofibromatosis type-1 patient who had multiple neurogenic tumors, FDG-PET/CT could distinguish malignant peripheral nerve sheath tumors from other benign lesions with similar MRI findings.
  
  
  CONCLUSIONS
  FDG-PET/CT is useful for differentiating malignant from benign soft tissue lesions, but malignant soft tissue lesions may show various patterns on FDG-PET, and MRI may be helpful for a differential diagnosis.
authors.affiliation: Department of Radiology, the University of Tokushima.
authors.forename: Hayato
authors.initials: H
authors.lastname: Nose
authors.forename: Hideki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Otomi
authors.forename: Kaori
authors.initials: K
authors.lastname: Terazawa
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Takao
authors.forename: Seiji
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18