title: Pseudo-peptides as novel antileptospiral agents: synthesis and spectral characterization.
abstract: In this paper, we describe the synthesis of novel class of pseudo-peptides derived by coupling an amino acid with a heterocyclic moiety containing free amine group using suitable coupling agents. The synthesized compounds were characterized using spectral ((1)H NMR, (13)C NMR and MS) techniques. Preliminary pharmacological assays for Leptospirosis were studied by test tube dilution (TDT) and micro dilution technique (MDT). In particular, all the analyses led to the conclusion that the synthesized compound inhibiting the Leptospira a causal organism of Leptospirosis.
authors.affiliation: Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India.
authors.forename: Chandan
authors.initials: C
authors.lastname: Shivamallu
authors.forename: Umesha
authors.initials: U
authors.lastname: Sharanaiah
authors.forename: Shiva Prasad
authors.initials: SP
authors.lastname: Kollur
authors.forename: Naveen Kumar R
authors.initials: NK
authors.lastname: Mallesh
authors.forename: Revanasiddappa D
authors.initials: RD
authors.lastname: Hosakere
authors.forename: V
authors.initials: V
authors.lastname: Balamurugan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007919:Leptospira / Q000187:drug effects*; D007922:Leptospirosis / Q000188:drug therapy; D008958:Models, Molecular; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014364:Tryptophan / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D057786:Peptidomimetics; D014364:Tryptophan
keywords: Anti-leptospiral activity; Minimum inhibitory concentration; Pseudo-peptide; Spectroscopic technique