title: Responding to R-spondin: slit2 potentiates intestinal regeneration.
abstract: Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature (Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia.
authors.forename: Toby J
authors.initials: TJ
authors.lastname: Phesse
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Sansom
mesh_terms: D000818:Animals; D005260:Female; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007422:Intestines / Q000166:cytology*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D019699:Thrombospondins / Q000378:metabolism*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D019699:Thrombospondins