title: Hemolytic anemia after ingestion of the natural hair dye Lawsonia inermis (henna) in a dog.
abstract: OBJECTIVE
  To describe the clinical presentation and case management of a dog that developed hemolytic anemia and evidence of renal tubular dysfunction after ingestion of a natural hair dye containing Lawsonia inermis (henna). To review cases of henna toxicity reported in the human literature.
  
  
  METHODS
  An 8-year-old female spayed Border Collie was presented 5 days after ingestion of a box of natural hair dye. The dog was showing signs of lethargy, vomiting, diarrhea, and weakness. A serum biochemistry profile, complete blood count, and urinalysis demonstrated evidence of renal tubular dysfunction and a regenerative anemia without spherocytosis. The dog was treated with a transfusion of packed RBCs and IV fluids, resulting in significant clinical improvement. Repeat diagnostics showed resolution of the anemia and no lasting evidence of tubular dysfunction.
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the first reported case in the veterinary literature of toxicity following ingestion of Lawsonia inermis (henna). Henna ingestion was associated with the development of hemolytic anemia and acute kidney injury.
authors.affiliation: Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Jardes
authors.forename: Linda A
authors.initials: LA
authors.lastname: Ross
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Markovich
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D031564:Lawsonia Plant / Q000633:toxicity*
chemical_list: D006202:Hair Dyes
keywords: Lawsone; acute kidney injury; glucosephosphate dehydrogenase deficiency; lawsonia plant; paraphenylenediamine