title: Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats.
abstract: A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
authors.affiliation: Department of Biochemistry, Bharathi Women's College, Affiliated to University of Madras, Chennai 600 108, India.
authors.forename: Periyanayagam
authors.initials: P
authors.lastname: Suguna
authors.forename: Arumugam
authors.initials: A
authors.lastname: Geetha
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Aruna
authors.forename: Ganesan Vijaiyan
authors.initials: GV
authors.lastname: Siva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D016227:Benzoquinones / Q000494:pharmacology*; D001835:Body Weight; D059305:Diet, High-Fat / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D007249:Inflammation; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008049:Lipase / Q000097:blood; D008054:Lipid Peroxides / Q000737:chemistry; D008297:Male; D018384:Oxidative Stress; D050500:Pancreatitis, Chronic / Q000139:chemically induced / Q000188:drug therapy*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D016227:Benzoquinones; D020382:Interleukin-18; D053583:Interleukin-1beta; D008054:Lipid Peroxides; D000431:Ethanol; D009195:Peroxidase; D008049:Lipase; D005978:Glutathione; C003466:thymoquinone