title: Individual plasma ghrelin changes in the same patients in hyperthyroid, hypothyroid and euthyroid state.
abstract: Ghrelin is a multifunctional peptide of widespread expression. Since it has been shown to influence energy homeostatis, its potential role in thyroid dysfunction may have clinical significance. In this study, plasma ghrelin changes have been analyzed in the same patients in three different thyroid states for the first time. The study group consisted of 16 patients who had been diagnosed with hyperthyroidism, were treated with radioiodine, developed hypothyroidism after treatment, and finally became euthyroid on l-thyroxine substitution. In the initial state of hyperthyroidism plasma ghrelin levels correlated negatively with fT3 and fT4. In hypothyroidism ghrelin concentration increased significantly (p<0.05). Although the mean value of plasma ghrelin tended to decrease in the euthyroid state, the individual difference between hypothyroidism and euthyroidism was not significant. Plasma ghrelin in euthyroidism was still significantly higher than in hyperthyroidism (p<0.05), and correlated positively with ghrelin levels in hyperthyroidism and hypothyroidism. In our opinion, plasma ghrelin fluctuations may reflect metabolic changes in patients with thyroid dysfunction. Moreover, it cannot be excluded that in thyroid disorders ghrelin acts as a compensatory factor, helping to balance metabolic disturbances.
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchala
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland. Electronic address: liberius@interia.pl.
authors.forename: Edyta
authors.initials: E
authors.lastname: Gurgul
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Stangierski
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wrotkowska
authors.affiliation: Department of Computer Science and Statistics, Poznan University of Medical Sciences, 79 Dabrowskiego St., 60-529 Poznan, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
mesh_terms: D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000532:radiotherapy; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D011832:Radiation Injuries / Q000097:blood* / Q000188:drug therapy; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood
chemical_list: D054439:Ghrelin; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: BMI; EDTA; GHS-R; Ghrelin; Hyperthyroidism; Hypothyroidism; Metabolism; NIS; RIA; TSH; Thyroid dysfunction; body mass index; ethylenediaminetetraacetic acid; fT(3); fT(4); free thyroxine; free triiodothyronine; growth hormone – secretagogue receptor; radioimmunoassay; sodium/iodide symporter; thyrotropin