title: Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
abstract: Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles.
authors.affiliation: Center for Infection and Immunity of Lille, CNRS UMR 8204, INSERM U 1019, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Tomavo
authors.forename: Christian
authors.initials: C
authors.lastname: Slomianny
authors.forename: Markus
authors.initials: M
authors.lastname: Meissner
authors.forename: Vern B
authors.initials: VB
authors.lastname: Carruthers
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008288:Malaria / Q000378:metabolism* / Q000473:pathology; D010961:Plasmodium / Q000378:metabolism*; D021381:Protein Transport; D015800:Protozoan Proteins / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism*; D014123:Toxoplasmosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D015800:Protozoan Proteins