title: The association between statin therapy during intensive care unit stay and the incidence of venous thromboembolism: a propensity score-adjusted analysis.
abstract: BACKGROUND
  Studies have shown that statins have pleiotropic effects on inflammation and coagulation; which may affect the risk of developing venous thromboembolism (VTE). The objective of this study was to evaluate the association between statin therapy during intensive care unit (ICU) stay and the incidence of VTE in critically ill patients.
  
  
  METHODS
  This was a post-hoc analysis of a prospective observational cohort study of patients admitted to the intensive care unit between July 2006 and January 2008 at a tertiary care medical center. The primary endpoint was the incidence of VTE during ICU stay up to 30 days. Secondary endpoint was overall 30-day hospital mortality. Propensity score was used to adjust for clinically and statistically relevant variables.
  
  
  RESULTS
  Of the 798 patients included in the original study, 123 patients (15.4%) received statins during their ICU stay. Survival analysis for VTE risk showed that statin therapy was not associated with a reduction of VTE incidence (crude hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.28-1.54, P=0.33 and adjusted HR 0.63, 95% CI 0.25-1.57, P=0.33). Furthermore, survival analysis for hospital mortality showed that statin therapy was not associated with a reduction in hospital mortality (crude HR 1.26, 95% CI 0.95-1.68, P=0.10 and adjusted HR 0.98, 95% CI 0.72-1.36, P=0.94).
  
  
  CONCLUSIONS
  Our study showed no statistically significant association between statin therapy and VTE risk in critically ill patients. This question needs to be further studied in randomized control trials.
authors.forename: Shmeylan A
authors.initials: SA
authors.lastname: Al Harbi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khedr
authors.forename: Hasan M
authors.initials: HM
authors.lastname: Al-Dorzi
authors.forename: Haytham M
authors.initials: HM
authors.lastname: Tlayjeh
authors.forename: Asgar H
authors.initials: AH
authors.lastname: Rishu
authors.affiliation: College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, MC 1425, PO Box 22490, Riyadh 1426, Saudi Arabia. yaseenarabi@yahoo.com.
authors.forename: Yaseen M
authors.initials: YM
authors.lastname: Arabi
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D007362:Intensive Care Units; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D008875:Middle Aged; D057216:Propensity Score; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D012529:Saudi Arabia; D013923:Thromboembolism / Q000139:chemically induced / Q000453:epidemiology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors