title: Regulation of hematopoietic stem cells by bone marrow stromal cells.
abstract: Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the bone marrow. The stem cell niche is thought to provide signals that support key HSC properties, including self-renewal capacity and long-term multilineage repopulation ability. The stromal cells that comprise the stem cell niche and the signals that they generate that support HSC function are the subjects of intense investigation. Here, we review the complex and diverse stromal cell populations that reside in the bone marrow and examine their contribution to HSC maintenance. We highlight recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in the bone marrow.
authors.affiliation: Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Anthony
authors.affiliation: Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: dlink@dom.wustl.edu.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Link
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D015820:Cadherins / Q000378:metabolism; D019070:Cell Lineage; D060833:Cellular Microenvironment; D054377:Chemokine CXCL12 / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D055153:Stem Cell Niche
chemical_list: D015820:Cadherins; D054377:Chemokine CXCL12
keywords: CXCL12; hematopoietic stem cells; mesenchymal stem cells; osteoblasts; stem cell niche