title: Diffuse large B-cell lymphoma of the sinonasal tract: analysis of survival in 852 cases.
abstract: OBJECTIVE
  Diffuse large B-cell lymphomas (DLBCLs) are rare tumors of the head and neck that often have non-specific presentations and significant morbidity and mortality. In this analysis we use a large cohort to compare the demographic and disease-specific parameters affecting survival and incidence of DLBCLs.
  
  
  METHODS
  The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to extract data regarding sinonasal diffuse large B-cell lymphoma between 1973 and 2009. A total of 852 cases of sinonasal DLBCLs were found. Presenting symptoms, demographics, disease specific survival, relative survival and survival by treatment modality were described for this rare tumor.
  
  
  RESULTS
  Overall disease specific survival (DSS) at 1-year was 84.7% and at 5 years was 68.0%. DSS was significantly lower for those not treated with radiation therapy, with 1- and 5-year survival rates of 77.3% and 62.5%, versus those treated with radiation therapy, with 1- and 5-year rates of 89.2% and 71.5% (p<0.05). Prognosis was significantly better for patients treated with radiation therapy (HR 0.6, p<0.05) while it was poorer for patients with involvement of multiple sinuses (HR 1.5, 1.8, p<0.05).
  
  
  CONCLUSIONS
  DLBCLs of the sinonasal tract are rare tumors of the head and neck. Survival is significantly improved for those treated with radiation therapy while the involvement of multiple sinuses is a negative prognostic indicator.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.
authors.forename: Vivek V
authors.initials: VV
authors.lastname: Kanumuri
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ; Department of Otolaryngology-Head & Neck Surgery, Mount Sinai School of Medicine, New York, NY.
authors.forename: Mohemmed N
authors.initials: MN
authors.lastname: Khan
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vazquez
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Mount Sinai School of Medicine, New York, NY.
authors.forename: Satish
authors.initials: S
authors.lastname: Govindaraj
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ.
authors.forename: Soly
authors.initials: S
authors.lastname: Baredes
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ. Electronic address: jean.anderson.eloy@gmail.com.
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000401:mortality* / Q000628:therapy; D008297:Male; D010255:Paranasal Sinus Neoplasms / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D018426:SEER Program; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology