title: Thrombomodulin is a Strong Predictor of Multiorgan Dysfunction Syndrome in Patients With Sepsis.
abstract: BACKGROUND
  Biomarkers of endothelial dysfunction are not recommended for routine laboratory investigation of the outcome prognosis and prediction of the course of sepsis.
  
  
  METHODS
  A total of 60 patients who fulfilled the criteria for diagnosis of sepsis were included in our study. Development of multiorgan dysfunction syndrome (MODS) in the first 48 hours was assessed. Differences between groups of patients with sepsis were assessed by Mann-Whitney U test and by Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors.
  
  
  RESULTS
  Level of thrombomodulin was significantly higher in group of patients with MODS than without MODS (P = .015). Levels of antithrombin (P = .026) and protein C (P = .035) were significantly lower in patients with MODS. Level of thrombomodulin was the strongest predictor in MODS development in first 48 hours (P = .028).
  
  
  CONCLUSIONS
  The level of thrombomodulin not only was able to distinguish the severity of sepsis but also was a significant predictor of MODS development.
authors.affiliation: Department of Anesthesia and Reanimation, Clinical Center of Vojvodina, Emergency Center, Novi Sad, Serbia dunjamihajlovic@hotmail.com.
authors.forename: Dunja M
authors.initials: DM
authors.lastname: Mihajlovic
authors.affiliation: Medical Faculty, Clinical Center of Vojvodina, Clinic for Infectious Diseases, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Dajana F
authors.initials: DF
authors.lastname: Lendak
authors.affiliation: Medical Faculty, Institute of Child and Adolescent Health Care of Vojvodina, Clinic of Pediatric Surgery, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Biljana G
authors.initials: BG
authors.lastname: Draskovic
authors.affiliation: Medical Faculty, Clinical Center of Vojvodina, Clinic of Gynecology and Obstetrics, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Aleksandra S Novakov
authors.initials: AS
authors.lastname: Mikic
authors.affiliation: Department of Hematology, Hemostasis, and Prevention of Thrombosis, Medical Faculty, Clinical Center of Vojvodina, Laboratory Medicine Center, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Gorana P
authors.initials: GP
authors.lastname: Mitic
authors.affiliation: Department of Biochemistry, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Tatjana N
authors.initials: TN
authors.lastname: Cebovic
authors.affiliation: Medical Faculty, Clinical Center of Vojvodina, Clinic for Infectious Diseases, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Snezana V
authors.initials: SV
authors.lastname: Brkic
mesh_terms: D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood*; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood*; D018180:Thrombomodulin / Q000032:analysis / Q000097:blood*; D019851:Thrombophilia
chemical_list: D018180:Thrombomodulin
keywords: endothelial dysfunction; hemostasis; hypercoagulability