title: Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism.
abstract: This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources: 92 individual roots of S. baicalensis from all over China, and secondary metabolites, medicinal materials and inorganic element contents obtained from the testing of 92 S. baicalensis rhizosphere soil samples. The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database. Most of the chemical constituents of S. baicalensis were negatively correlated to latitude and positively correlated to temperature; generally, the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes. By gradual regression analysis, it was found that the content of baicalin in S. baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high (excluding Mg and Ca), which has a negative effect on the accumulation of chemical constituents in S. baicalensis. Based on the cluster analysis of 21 constituents, S. baicalensis from different places of origin was divided into two groups, and S. baicalensis was not genuine only in a specific small region. Within the zone from Chifeng, Inner Mongolia to Taibai, Shaanxi is suitable for accumulation of secondary metabolites of S. baicalensis and such a zone represents a suitable distribution and potential genuine producing area.
authors.affiliation: National Resources Center of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
authors.forename: Lanping
authors.initials: L
authors.lastname: Guo
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Manxi
authors.initials: M
authors.lastname: Zhao
authors.forename: Weifeng
authors.initials: W
authors.lastname: Ma
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.forename: Bangxing
authors.initials: B
authors.lastname: Han
authors.forename: Naifu
authors.initials: N
authors.lastname: Chen
authors.forename: Luqi
authors.initials: L
authors.lastname: Huang
mesh_terms: D004777:Environment; D029001:Herbal Medicine; D007287:Inorganic Chemicals / Q000032:analysis*; D018517:Plant Roots / Q000737:chemistry*; D012044:Regression Analysis; D031364:Scutellaria baicalensis / Q000737:chemistry*; D012987:Soil / Q000737:chemistry; D013696:Temperature
chemical_list: D007287:Inorganic Chemicals; D012987:Soil