title: Role of miR-181 family in regulating vascular inflammation and immunity.
abstract: The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli.
authors.affiliation: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: Xinghui
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: Alan
authors.initials: A
authors.lastname: Sit
authors.affiliation: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. Electronic address: mfeinberg@partners.org.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Feinberg
mesh_terms: D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D032383:Myocytes, Cardiac / Q000502:physiology; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014652:Vascular Diseases / Q000209:etiology* / Q000473:pathology
chemical_list: C540193:MIrn181 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B