title: Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine whether granulosa cells contribute to excess androgen production, by assessing inhibin B (Inh B) responses to hCG in women with polycystic ovary syndrome (PCOS) and in normal women.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Twenty women with PCOS and 16 normal women.
  
  
  METHODS
  Blood samples obtained before and 24 hours after injection of 25 μg recombinant hCG (r-hCG).
  
  
  METHODS
  Basal and stimulated Inh B, E2, androstenedione (A), and T responses after r-hCG administration.
  
  
  RESULTS
  In normal and PCOS women, r-hCG induced a significant reduction of Inh B levels. Lowered Inh B responses were not related to body mass index, PCOS status, or age by multivariate regression. Recombinant hCG significantly increased serum A and E2 in both normal and PCOS women.
  
  
  CONCLUSIONS
  In normal and PCOS women, Inh B production was decreased following r-hCG administration. These findings strongly suggest that in PCOS women androgen excess is not enhanced by LH-stimulated Inh B production.
  
  
  BACKGROUND
  NCT00747617.
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: Rana F
authors.initials: RF
authors.lastname: Shayya
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Rosencrantz
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: Sandy S
authors.initials: SS
authors.lastname: Chuan
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: Heidi
authors.initials: H
authors.lastname: Cook-Andersen
authors.affiliation: Department of Biomedical Sciences, University of South Carolina School of Medicine, Greenville, South Carolina.
authors.forename: William E
authors.initials: WE
authors.lastname: Roudebush
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: H
authors.initials: H
authors.lastname: Irene Su
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Shimasaki
authors.affiliation: Department of Reproductive Medicine, University of California San Diego, La Jolla, California. Electronic address: rjchang@ucsd.edu.
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007265:Inhibins / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins; C422364:inhibin B; D007265:Inhibins
keywords: Inhibin B; hCG; polycystic ovary syndrome