title: Endometrial serous carcinoma: its molecular characteristics and histology-specific treatment strategies.
abstract: Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC.
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kn88@med.shimane-u.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakayama
authors.forename: Naomi
authors.initials: N
authors.lastname: Nakayama
authors.forename: Masako
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyazaki