title: Mechanical control of organ size in the development of the Drosophila wing disc.
abstract: Control of cessation of growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due to its growth. In particular, it was proposed that stretching of the tissue leads to an increase in cell proliferation. Using the model system of the Drosophila wing imaginal disc, we directly stretch the tissue finding a significant increase in cell proliferation, thus confirming this hypothesis. In addition, we characterize the growth over the entire growth period of the wing disc finding a correlation between the apical cell area and cell proliferation rate.
  87.19.lx, 87.18.Nq, 87.80.Ek, 87.17.Ee, 87.85.Xd.
authors.affiliation: Physik-Institut, University of Zurich, Zurich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schluck
authors.forename: Ulrike
authors.initials: U
authors.lastname: Nienhaus
authors.forename: Tinri
authors.initials: T
authors.lastname: Aegerter-Wilmsen
authors.forename: Christof M
authors.initials: CM
authors.lastname: Aegerter
mesh_terms: D000818:Animals; D004330:Drosophila / Q000254:growth & development*; D055595:Mechanical Phenomena; D009929:Organ Size; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development*