title: Long term cardiovascular consequences of chronic lung disease of prematurity.
abstract: Pulmonary arterial (PA) hypertension in preterm infant is an important consequence of chronic lung disease of prematurity (CLD) arising mainly due to impaired alveolar development and dysregulated angiogenesis of the pulmonary circulation. Although PA pressure and resistance in these children normalise by school age, their pulmonary vasculature remains hyper-reactive to hypoxia until early childhood. Furthermore, there is evidence that systemic blood pressure in preterm born children with or without CLD is mildly increased at school age and in young adulthood when compared to term-born children. Arterial stiffness may be increased in CLD survivors due to increased smooth muscle tone of the pre-resistance and resistance vessels rather than the loss of elasticity in the large arteries. This review explores the long term effects of CLD on the pulmonary and systemic circulations along with their clinical correlates and therapeutic approaches.
authors.affiliation: Department of Child Health, School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, UK. Electronic address: pooncy@cardiff.ac.uk.
authors.forename: Chuen Yeow
authors.initials: CY
authors.lastname: Poon
authors.forename: Martin Oliver
authors.initials: MO
authors.lastname: Edwards
authors.forename: Sailesh
authors.initials: S
authors.lastname: Kotecha
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D002908:Chronic Disease; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D013997:Time Factors
keywords: Arterial hypertension; Arterial stiffness; Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Lung development; Pulmonary arterial hypertension