title: Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells.
abstract: HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, N-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.
authors.affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University.
authors.forename: Ryo
authors.initials: R
authors.lastname: Nakano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
authors.forename: Gi-Wook
authors.initials: GW
authors.lastname: Hwang
mesh_terms: D016923:Cell Death / Q000187:drug effects* / Q000235:genetics*; D005033:Ethylmaleimide / Q000633:toxicity*; D015870:Gene Expression / Q000235:genetics; D055785:Gene Knockdown Techniques; D057809:HEK293 Cells; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects* / Q000235:genetics* / Q000502:physiology; D010269:Paraquat / Q000633:toxicity*; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering
chemical_list: C484414:HOXB13 protein, human; D018398:Homeodomain Proteins; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D006861:Hydrogen Peroxide; D005033:Ethylmaleimide; D010269:Paraquat