title: Isolation and bioassay screening of medicinal plant endophytes from eastern Canada.
abstract: Eighty-one distinct fungal endophytes were isolated from 12 traditionally used medicinal plants from New Brunswick, Canada. This is the first report of endophytes from 8 of the 12 host plants. One hundred and sixty-two crude extracts derived from the mycelia and spent fermentation broths of liquid cultures of each endophyte were screened for antibacterial and antifungal activity. Twenty-two extracts were active against Staphylococcus aureus while 30 were active against Pseudomonas aeruginosa. Twelve crude extracts were found to be active against Candida albicans.
authors.affiliation: a Department of Biology, University of New Brunswick, 100 Tucker Park Road, Saint John, NB E2l 4L5, Canada.
authors.forename: Katelyn T
authors.initials: KT
authors.lastname: Ellsworth
authors.forename: Trevor N
authors.initials: TN
authors.lastname: Clark
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay; D002176:Candida albicans / Q000187:drug effects; D060026:Endophytes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*; D005658:Fungi / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D009509:New Brunswick; D010946:Plants, Medicinal / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents