title: Histopathological diagnoses of adnexal masses: which parameters are relevant in preoperative assessment?
abstract: OBJECTIVE
  The aim of the study was to assess which clinical, laboratory and ultrasound characteristics of adnexal masses might predict the histopathological nature of the disease.
  
  
  METHODS
  The study involved all women treated at the Clinic of Gynecology and Obstetrics Clinical Centre of Serbia for adnexal tumors between July 1, 2010 and December 31, 2011. On admission, detailed anamnestic and laboratory data were obtained, expert ultrasound scan performed and RMI was calculated for all patients. Data were related to histopathological findings and statistically analyzed.
  
  
  RESULTS
  The study included 540 women out of which 85 had malignant (seven diagnoses), 435 benign (seven diagnoses) and 20 borderline tumors. All types of malignant and borderline tumors were more frequent in postmenopausal women (p=0.000). Only papillary adenocarcinoma significantly more often produced early metastases (p=0.000). Ascites is a common finding in Krukenberg tumors, granulose cell tumors and papillary adenocarcinomas. There were significant differences between tumor diagnoses regarding the levels of Ca 125 and CEA, erythrocyte sedimentation rate (ESR) and risk of malignancy index (RMI) (p<0.05). No significant differences were found within the group of malignant tumor types regarding the levels of all examined tumor markers, ESR as well as RMI (p>0.05).
  
  
  CONCLUSIONS
  In the light of our results, patient age, menopausal status, blood levels of Ca 125, CEA and ESR, as well as calculated RMI, can predict the nature of adnexal masses. Unfortunately none of the examined parameters can accurately determine the exact histopathological diagnosis of the adnexal tumor.
authors.affiliation: Clinic of Obstetrics and Gynecology, Clinical Centre of Serbia, Dr Koste Todorovica 26, Belgrade, Serbia. terzicmilan@yahoo.co.uk
authors.forename: Milan
authors.initials: M
authors.lastname: Terzic
authors.forename: Jelena
authors.initials: J
authors.lastname: Dotlic
authors.forename: Natasa
authors.initials: N
authors.lastname: Brndusic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Arsenovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Likic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Ladjevic
authors.forename: Sanja
authors.initials: S
authors.lastname: Maricic
authors.forename: Sasa
authors.initials: S
authors.lastname: Andrijasevic
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology; D000291:Adnexal Diseases / Q000175:diagnosis* / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D001201:Ascites / Q000175:diagnosis / Q000453:epidemiology; D018394:CA-125 Antigen / Q000378:metabolism; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010048:Ovarian Cysts / Q000175:diagnosis / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D011300:Preoperative Care / Q000379:methods*; D018570:Risk Assessment; D012307:Risk Factors; D055771:Serbia / Q000453:epidemiology; D016387:Women's Health
chemical_list: D018394:CA-125 Antigen