title: Bis-amide transition metal complexes: isomerism and DNA interaction study.
abstract: A quatridentate bis-amide ligand, N,N'-propylenebis(salicylamide) H2pbs, and its transition metal complexes [M(pbs)(H2O)2], where M=Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized and characterized by elemental analysis, UV-Vis, IR, NMR, Mass, EPR, molar conductivity, magnetic moment values and thermal analysis. The NMR spectrum of ligand evidences the E/Z isomerism. All the evidences reveal that the metal ions adopt octahedral geometry with metal:ligand:solvent ratio 1:1:2. The conductivity measurements exhibit that the complexes are non-electrolytes. DNA binding properties of these complexes have been explored by UV-Vis and cyclic voltammetry. The results indicate that these complexes are good intercalators.
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India. Electronic address: ramchem1964@gmail.com.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Raman
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
authors.forename: Ramasubbu
authors.initials: R
authors.lastname: Rajakumar
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D005399:Fishes; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology; D007536:Isomerism; D012457:Salicylamides / Q000737:chemistry* / Q000494:pharmacology; D028561:Transition Elements / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D007364:Intercalating Agents; D012457:Salicylamides; D028561:Transition Elements; D004247:DNA; C031060:salicylamide
keywords: Bis-amide; DNA interaction; E/Z isomerism; Intercalative binding; Salicylamide