title: Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin.
abstract: Poly (N-isopropylacrylamide-methyl methacrylic acid, PNIPAAm-MAA)-grafted magnetic nanoparticles were synthesized using silane-coated magnetic nanoparticles as a template for radical polymerization of N-isopropylacrylamide and methacrylic acid. Properties of these nanoparticles, such as size, drug-loading efficiency, and drug release kinetics, were evaluated in vitro for targeted and controlled drug delivery. The resulting nanoparticles had a diameter of 100 nm and a doxorubicin-loading efficiency of 75%, significantly higher doxorubicin release at 40°C compared with 37°C, and pH 5.8 compared with pH 7.4, demonstrating their temperature and pH sensitivity, respectively. In addition, the particles were characterized by X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In vitro cytotoxicity testing showed that the PNIPAAm-MAA-coated magnetic nanoparticles had no cytotoxicity and were biocompatible, indicating their potential for biomedical application.
authors.affiliation: Department of Medicinal Chemistry, Tabriz University of Medical Sciences, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Zarghami
authors.forename: Haleh
authors.initials: H
authors.lastname: Mikaeili
authors.forename: Davoud
authors.initials: D
authors.lastname: Asgari
authors.forename: Amir Mohammad
authors.initials: AM
authors.lastname: Goganian
authors.forename: Hanie Khaksar
authors.initials: HK
authors.lastname: Khiabani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samiei
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
keywords: biocompatibility; doxorubicin release; drug loading; magnetic nanoparticles