title: The effect of gold and iron-oxide nanoparticles on biofilm-forming pathogens.
abstract: Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel. Here, we studied the effect of gold and iron oxide nanoparticles on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We report that biofilm growth was reduced at higher concentrations of gold and iron-oxide nanoparticles compared to absence of nanoparticles. Thus nanoparticles with appropriate concentration could show significant reduction in biofilm formation.
authors.affiliation: Department of Biomedical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamilnadu 603110, India.
authors.forename: Madhu Bala
authors.initials: MB
authors.lastname: Sathyanarayanan
authors.forename: Reneta
authors.initials: R
authors.lastname: Balachandranath
authors.forename: Yuvasri
authors.initials: Y
authors.lastname: Genji Srinivasulu
authors.forename: Sathish Kumar
authors.initials: SK
authors.lastname: Kannaiyan
authors.forename: Guruprakash
authors.initials: G
authors.lastname: Subbiahdoss