title: The deleterious role of basophils in systemic lupus erythematosus.
abstract: Systemic lupus erythematosus is a complex autoimmune disease of multifactorial origins. All compartments of the immune system appear to be affected, at least in some way, and to contribute to disease pathogenesis. Because of an escape from negative selection autoreactive T and B cells accumulate in SLE patients leading to the production of autoantibodies mainly raised against nuclear components and their subsequent deposition into target organs. We recently showed that basophils, in an IgE and IL-4 dependent manner, contribute to SLE pathogenesis by amplifying autoantibody production. Here, we summarize what we have learned about the deleterious role of basophils in lupus both in a mouse model and in SLE patients. We discuss which possible pathways could be involved in basophil activation and recruitment to secondary lymphoid organs during SLE, and how basophils may amplify autoantibody production.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S699, Université Paris Diderot, Faculté de Médecine site Bichat, Labex Inflamex, DHU Fire - 16 rue Henri Huchard, 75870 Paris cedex 18, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pellefigues
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charles
mesh_terms: D000818:Animals; D001491:Basophils / Q000276:immunology*; D002465:Cell Movement; D004195:Disease Models, Animal; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology