title: Pediatric cerebral stroke: susceptibility-weighted imaging may predict post-ischemic malignant edema.
abstract: Susceptibility-weighted imaging (SWI) is an advanced MRI technique providing information on the blood oxygenation level. Deoxyhemoglobin is increased in hypoperfused tissue characterized by SWI-hypointensity, while high oxyhemoglobin concentration within hyperperfused tissue results in a SWI iso- or hyperintensity compared to healthy brain tissue. We describe a child with a stroke, where SWI in addition to excluding hemorrhage and delineating the thrombus proved invaluable in determining regions of hyperperfusion or luxury perfusion, which contributed further to the prognosis including an increased risk of developing post-ischemic malignant edema.
authors.affiliation: Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, MD, USA - thuisma1@jhmi.edu.
authors.forename: Thangamadhan
authors.initials: T
authors.lastname: Bosemani
authors.forename: Andrea
authors.initials: A
authors.lastname: Poretti
authors.forename: Gunes
authors.initials: G
authors.lastname: Orman
authors.forename: Avner
authors.initials: A
authors.lastname: Meoded
authors.forename: Thierry A G M
authors.initials: TA
authors.lastname: Huisman
mesh_terms: D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D002648:Child; D004487:Edema / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020521:Stroke / Q000150:complications* / Q000473:pathology
keywords: children; hyperperfusion; neuroimaging; post-ischemic malignant edema; stroke; susceptibility-weighted imaging