title: The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress.
abstract: In this paper the oil from seeds of Amaranthus cruentus L. (AmO) was shown to be an efficient modulator of the physical chemical properties of artificial lipid and rat hepatocyte plasma membranes. AmO improved the membrane stability, their stress resistance and the adsorption of neurotensin to plasma membranes with the distinct biphasic interactions being observed even after adrenalin stress exposure. The analysis of pro-/antioxidant balance in rat blood revealed a mild prooxidant activity after AmO intake, which was accompanied by accumulation of oxidative destruction products in plasma membranes. This prooxidant action of AmO was corroborated in vitro in an adrenalin autooxidation model. On the other hand, the observed improved resistance to adrenalin stress in AmO supplemented rats was associated with an antioxidant response in blood and plasma membrane studies. The AmO effects can be attributed to the modulation of the metabolic pathways involved into oxygen and free radical homeostasis.
authors.affiliation: Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine. Electronic address: yelisol@gmail.com.
authors.forename: O P
authors.initials: OP
authors.lastname: Yelisyeyeva
authors.forename: K O
authors.initials: KO
authors.lastname: Semen
authors.forename: G V
authors.initials: GV
authors.lastname: Ostrovska
authors.forename: D V
authors.initials: DV
authors.lastname: Kaminskyy
authors.forename: T V
authors.initials: TV
authors.lastname: Sirota
authors.forename: N
authors.initials: N
authors.lastname: Zarkovic
authors.forename: D
authors.initials: D
authors.lastname: Mazur
authors.forename: O D
authors.initials: OD
authors.lastname: Lutsyk
authors.forename: K
authors.initials: K
authors.lastname: Rybalchenko
authors.forename: A
authors.initials: A
authors.lastname: Bast
mesh_terms: D027721:Amaranthus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D008055:Lipids / Q000737:chemistry*; D008297:Male; D009496:Neurotensin / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008051:Lipid Bilayers; D008055:Lipids; D010938:Plant Oils; D017382:Reactive Oxygen Species; D009496:Neurotensin; D004837:Epinephrine
keywords: AL; AOD; Adaptive stress response; Adrenalin-induced stress; AmO; Amaranth oil; FR; Hormetic response; Membrane monolayer; Neurotensin; OS; Oxidative stress correction; PC; PS; RP; Rats; antioxidant defense; asolectin; free radical; oxidative stress; phosphatidylcholine; phosphatidylserine; regulatory peptides