title: Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer.
abstract: We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues. We aimed to evaluate the feasibility of detecting BCL6B methylation in plasma DNA as a potential biomarker for gastric cancer. Hypermethylation of the CpG islands in BCL6B promoter was detected in 42.5% (17/40) plasma DNA samples from gastric cancer patients, while no methylation was found in the plasma DNA of healthy controls (p < 0.001). BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer.
authors.affiliation: Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin , NT , Hong Kong .
authors.forename: Qingfan
authors.initials: Q
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Lixia
authors.initials: L
authors.lastname: Xu
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zeng
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
mesh_terms: D000368:Aged; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000097:blood*; D018899:CpG Islands; D019175:DNA Methylation; D017931:DNA Primers; D004273:DNA, Neoplasm / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: C486398:BCL6B protein, human; D014408:Biomarkers, Tumor; D017931:DNA Primers; D004273:DNA, Neoplasm; D012097:Repressor Proteins