title: Mechanism of action of salvianolic acid B by module-based network analysis.
abstract: Salvianolic Acid B (Sal B) is one of the main medicinal ingredients of Radix Salvia miltiorrhiza (Danshen) and possesses a variety of pharmacological effects. The purpose of this study was to discover the new mechanism of action of Sal B based on the protein interaction network (PIN) analysis. A PIN of Sal B was constructed with 852 nodes and 8,626 interactions. By fast agglomerate algorithm based on the edge clustering coefficients (FAG-EC), 11 modules were detected from the network. Gene ontology (GO) enrichment analysis of the modules demonstrated that the roles of Sal B played in cardiovascular disease were related to multiple biological processes, which could represent the characteristics of Chinese Material Medica (CMM) as a whole to regulate the disease. The most interesting finding of this work was that the anti-inflammatory effect of Sal B was due to the immune response of T lymphocytes by regulating IL-2 family, CD3E, CD79A, MAP3K7 and PRKCQ. Therefore, the module-based network analysis will be an effective method for better understanding CMM.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ren
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.forename: Shifeng
authors.initials: S
authors.lastname: Wang
authors.forename: Chenxi
authors.initials: C
authors.lastname: Zhai
authors.forename: Yusu
authors.initials: Y
authors.lastname: He
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yanjiang
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D000465:Algorithms; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001572:Benzofurans / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D016000:Cluster Analysis; D019295:Computational Biology; D016208:Databases, Factual; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D010936:Plant Extracts / Q000494:pharmacology; D025941:Protein Interaction Mapping; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013678:Technology, Pharmaceutical; D053630:Depsides
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C076944:salvianolic acid B; D053630:Depsides
keywords: GO enrichment analysis; Protein interaction network; Salvianolic Acid B; mechanism of action; module