title: Windows to the soul: vision science as a tool for studying biological mechanisms of information processing deficits in schizophrenia.
abstract: Cognitive and information processing deficits are core features and important sources of disability in schizophrenia. Our understanding of the neural substrates of these deficits remains incomplete, in large part because the complexity of impairments in schizophrenia makes the identification of specific deficits very challenging. Vision science presents unique opportunities in this regard: many years of basic research have led to detailed characterization of relationships between structure and function in the early visual system and have produced sophisticated methods to quantify visual perception and characterize its neural substrates. We present a selective review of research that illustrates the opportunities for discovery provided by visual studies in schizophrenia. We highlight work that has been particularly effective in applying vision science methods to identify specific neural abnormalities underlying information processing deficits in schizophrenia. In addition, we describe studies that have utilized psychophysical experimental designs that mitigate generalized deficit confounds, thereby revealing specific visual impairments in schizophrenia. These studies contribute to accumulating evidence that early visual cortex is a useful experimental system for the study of local cortical circuit abnormalities in schizophrenia. The high degree of similarity across neocortical areas of neuronal subtypes and their patterns of connectivity suggests that insights obtained from the study of early visual cortex may be applicable to other brain regions. We conclude with a discussion of future studies that combine vision science and neuroimaging methods. These studies have the potential to address pressing questions in schizophrenia, including the dissociation of local circuit deficits vs. impairments in feedback modulation by cognitive processes such as spatial attention and working memory, and the relative contributions of glutamatergic and GABAergic deficits.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University and Veterans Affairs Palo Alto Healthcare System Palo Alto, CA, USA.
authors.forename: Jong H
authors.initials: JH
authors.lastname: Yoon
authors.forename: Summer L
authors.initials: SL
authors.lastname: Sheremata
authors.forename: Ariel
authors.initials: A
authors.lastname: Rokem
authors.forename: Michael A
authors.initials: MA
authors.lastname: Silver
keywords: fMRI; magnetic resonance spectroscopy; psychophysics; schizophrenia; visual system