title: Two-year follow-up in patients treated with emphysematous lung sealant for advanced emphysema.
abstract: Endoscopic lung volume-reduction therapy for emphysema has been associated with therapeutic responses smaller in magnitude and less durable than surgical volume reduction (LVRS). Bronchoscopic emphysematous lung sealant (ELS) therapy has been shown to produce improvements in pulmonary function similar to surgery at 1 year. This case series summarizes safety and efficacy data of all patients from the initial ELS study out to 2 years. Between 1 and 2 years, there were three all-cause adverse events requiring hospitalization. One patient went on to successful lung transplant. Improvements relative to baseline in spirometry (change in FEV1: + 14.3 ± 33.1%; change in FVC: + 5.8 ± 23.2%) and diffusing capacity (change in diffusing capacity of the lung for carbon monoxide: + 10.6 ± 20.6%) were observed at 2 years. An exponential model fit to FEV₁ data at 6, 12, 18, and 24 months predicted improvements from a baseline of > 5% out to 4.1 years, similar to what has been reported following surgery. This report confirms long-term safety and efficacy following ELS therapy in advanced emphysema. Studies in a larger cohort are needed to define the role of ELS therapy in the treatment algorithm of patients with this condition.
authors.affiliation: Pulmonary Institute Rabin Medical Center, Beilinson Hospital, Petach Tikva. Electronic address: kremerm@clalit.org.il.
authors.forename: Mordechai R
authors.initials: MR
authors.lastname: Kramer
authors.affiliation: Department of Thoracic Surgery, Soroka Medical Center, Be'er Sheeva, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Refaely
authors.affiliation: Department of Pulmonary Medicine, Soroka Medical Center, Be'er Sheeva, Israel.
authors.forename: Nimrod
authors.initials: N
authors.lastname: Maimon
authors.affiliation: Pulmonary Institute Rabin Medical Center, Beilinson Hospital, Petach Tikva.
authors.forename: Dror
authors.initials: D
authors.lastname: Rosengarten
authors.affiliation: Pulmonary Institute Rabin Medical Center, Beilinson Hospital, Petach Tikva.
authors.forename: Oren
authors.initials: O
authors.lastname: Fruchter
mesh_terms: D000368:Aged; D001999:Bronchoscopy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods*; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000601:surgery*; D011788:Quality of Life; D012129:Respiratory Function Tests; D013997:Time Factors; D016896:Treatment Outcome