title: Fronto-parietal dorsal and ventral pathways in the context of different linguistic manipulations.
abstract: This study investigates structural connectivity between left fronto-parietal brain regions that were identified in a previous fMRI study which used different linguistic manipulation tasks. Diffusion-weighted images were acquired from 20 volunteers. Structural connectivity between brain regions from the fMRI study was computed using probabilistic fiber tracking. For suprasegmental manipulation, left inferior parietal lobule (IPL) and left inferior frontal gyrus (IFG), pars opercularis, were connected by a dorsal pathway via the arcuate fascicle and superior longitudinal fascicle III. For segmental manipulation, left IPL and IFG, pars triangularis, were connected by a ventral pathway via the middle longitudinal fascicle and the extreme capsule. We conclude that the dorsal pathway provides a route for mapping from phonological memory in IPL to the inferior frontal articulatory network while the ventral pathway could facilitate the modulation of phonological units based on lexical-semantic aspects, mediate the complexity of auditory objects and the unification of actor-event schemata.
authors.affiliation: Department of Neurology, University Medical Center Freiburg, Breisacher Str. 64, D-70196 Freiburg, Germany; Freiburg Brain Imaging, University Medical Center Freiburg, Breisacher Str. 64, D-79106 Freiburg, Germany. Electronic address: philipp.kellmeyer@uniklinik-freiburg.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Kellmeyer
authors.forename: Wolfram
authors.initials: W
authors.lastname: Ziegler
authors.forename: Claudia
authors.initials: C
authors.lastname: Peschke
authors.forename: Eisenberger
authors.initials: E
authors.lastname: Juliane
authors.forename: Susanne
authors.initials: S
authors.lastname: Schnell
authors.forename: Annette
authors.initials: A
authors.lastname: Baumgaertner
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
authors.forename: Dorothee
authors.initials: D
authors.lastname: Saur
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology*; D055815:Young Adult
keywords: DTI; Dorsal; Fronto-parietal; Pathway; Probabilistic fiber tracking; Ventral