title: BDNF (I)rising from exercise.
abstract: Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FNDC5, the precursor of irisin, via the transcriptional complex PGC-1α/Errα.
authors.affiliation: Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA. Electronic address: bxu@scripps.edu.
authors.forename: Baoji
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010805:Physical Conditioning, Animal; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C571428:FNDC5 protein, mouse; D005353:Fibronectins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D014157:Transcription Factors