title: Peripheral T-cell tolerance in hosts with acute myeloid leukemia.
abstract: Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon.
authors.affiliation: Department of Medicine; University of Chicago; Chicago, IL USA.
authors.forename: Xiufen
authors.initials: X
authors.lastname: Chen
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Kline
authors.forename: Justin
authors.initials: J
authors.lastname: Kline
keywords: AML; APC; anergy; deletion; peripheral tolerance