title: Fish in a Dish: Drug Discovery for Hearing Habilitation.
abstract: The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several characteristics of the zebrafish, such as its small size and external location of sensory hair cells, uniquely position it as an ideal model organism for the study of hair cell toxicity, protection, and regeneration. We have used this model to screen for drugs that affect each of these aspects of hair cell biology and have identified compounds that affect each of these processes. The identification of such drugs and drug-like compounds holds promise in the future ability to stem hearing loss in the human population.
authors.affiliation: Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington ; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.
authors.forename: Robert
authors.initials: R
authors.lastname: Esterberg
authors.forename: Allison B
authors.initials: AB
authors.lastname: Coffin
authors.forename: Henry
authors.initials: H
authors.lastname: Ou
authors.forename: Julian A
authors.initials: JA
authors.lastname: Simon
authors.forename: David W
authors.initials: DW
authors.lastname: Raible
authors.forename: Edwin W
authors.initials: EW
authors.lastname: Rubel
keywords: Chemical genetics; hair cell; lateral line; ototoxicity; zebrafish