title: What does it take to deliver an international neurosurgical trial? Experiences from STICH II.
abstract: OBJECTIVE
  When undertaking multicentre randomised controlled trials some obstacles cause a slower than required recruitment rate. This article discusses factors that affected the completion of the international neurosurgical trial STICH II, which took almost 6 years.
  
  
  METHODS
  We reviewed the following factors: recruitment of participating sites, patient recruitment, patient screening, trial fatigue and maintenance of profile and maintenance of quality and standards. We discuss the practical strategies employed by the STICH II team to address these factors and optimise patient recruitment.
  
  
  CONCLUSIONS
  Although STICH II attained its final recruitment target, it took longer to complete than anticipated. Publishing and sharing the experiences of the STICH II trial team is an important step towards ensuring that other potential neurosurgical triallists are aware of the issues that can slow patient recruitment and strategies that can help to overcome them.
authors.affiliation: Neurosurgical Trials Unit, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Gillian
authors.initials: G
authors.lastname: Kenyon
authors.forename: Barbara
authors.initials: B
authors.lastname: Gregson
authors.forename: A David
authors.initials: AD
authors.lastname: Mendelow
authors.forename: Elise
authors.initials: E
authors.lastname: Rowan
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D038622:Internationality; D009422:Nervous System Diseases / Q000628:therapy*; D009493:Neurosurgery / Q000379:methods; D018579:Patient Selection; D016896:Treatment Outcome
keywords: CT scan; neurosurgery; stroke; surgery