title: Personal hair dyes use and risk of glioma: a meta-analysis.
abstract: OBJECTIVE
  Use of hair dyes for glioma risk has been investigated in numerous epidemiological studies, but the evidence is inconsistent. Therefore, a meta-analysis was performed to estimate the association between hair dyes use and glioma risk.
  
  
  METHODS
  We searched PubMed and EMBASE databases without any limitations, covering all papers published by the end of March 8, 2013. Cohort and case-control studies reporting relative risk estimates (RRs) with corresponding 95% confidence intervals (CIs) (or data to calculate them) on this issue were included. Random effects models were used to calculate the pooled RRs and corresponding 95% CIs.
  
  
  RESULTS
  Four case-control and two cohort studies were included in this meta-analysis. The summary RRs and 95 % CIs for ever users of any hair dyes were 1.132 (0.887-1.446) for all studies, 1.291 (0.938-1.777) for case-control studies, and 0.903 (0.774-1.054) for cohort studies. In the subgroup analysis by geographic regions and sex, the similar results were detected. No significant associations were also observed among the studies which reported data involving permanent hair dye use and duration of any hair dye use.
  
  
  CONCLUSIONS
  In summary, the results of our study demonstrated that hair dyes use is not associated with risk of glioma.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University 188 Shizi Road, Suzhou, 215006, Jiangsu, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Shao
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Qi
authors.forename: Guo-Zhen
authors.initials: GZ
authors.lastname: Hui
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
keywords: Glioma; hair dyes; meta-analysis; risk factor