title: [Biological insulin resistance in Congolese woman with polycystic ovary syndrome (PCOS)].
abstract: OBJECTIVE
  Metabolic features of polycystic ovary syndrome (PCOS) have been poorly investigated in African women where environmental factors are different from those occurring in developed countries. This study aimed to determine the frequency and features of insulin resistance (IR) in Congolese women affected by polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This was a case-control study conducted in women received in three hospital institutions in Kinshasa from 2006-2007. Blood samples were taken to measure HDL and LDL cholesterol, triglycerides, fasting insulin and glucose levels, and the homeostatic model (HOMA-IR) was used to assess IR under basal conditions.
  
  
  RESULTS
  Fifty-five Congolese women with PCOS and forty-four normal women (mean age 24 ± 6.8 years) were included in the study. Although body mass index was not statistically different between PCOS and control women, IR evaluated by the HOMA-IR was detected in 39.3% of PCOS women. Fasting insulin level was the most significant determinant of IR in the Congolese women with PCOS (OR 2.134 [1.360-3.348]; P<0.001).
  
  
  CONCLUSIONS
  Nearly one in two women from Congo affected by PCOS is IR and this feature is independent of overweight and central fat distribution. HOMA-IR is the most suitable index than the clinical parameters for detecting IR in these women.
authors.affiliation: Service de gynécologie-obstétrique, centre hospitalier Monkole, 4804, avenue Ngafani C/Mont Ngafula, Kinshasa, République démocratique du Congo. Electronic address: chantalamisi@yahoo.fr.
authors.forename: C
authors.initials: C
authors.lastname: Amisi
authors.forename: L
authors.initials: L
authors.lastname: Mputu
authors.forename: E
authors.initials: E
authors.lastname: Mboloko
authors.forename: E
authors.initials: E
authors.lastname: Bieleli
authors.forename: P
authors.initials: P
authors.lastname: Pozzili
mesh_terms: D016022:Case-Control Studies; D003223:Congo; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*; D012189:Retrospective Studies; D055815:Young Adult
keywords: Congolese women; Femme congolaise; HOMA-IR; Insulin; Insulin resistance; Insuline; Insulinorésistance; PCOS; SOPK