title: Risk markers of juvenile idiopathic arthritis-associated uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry.
abstract: OBJECTIVE
  To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and non-Hispanic white (NHW) children.
  
  
  METHODS
  There were 4983 children with JIA enrolled in the CARRA Registry. Of those, 3967 NHW and AA children were included in this study. Demographic and disease-related data were collected from diagnosis to enrollment. Children with JIA were compared to those with JIA-U. Children with JIA-U were also compared by race.
  
  
  RESULTS
  There were 459/3967 children (11.6%) with JIA-U in our cohort with a mean age (SD) of 11.4 years (± 4.5) at enrollment. Compared to children with JIA, they were younger at arthritis onset, more likely to be female, had < 5 joints involved, had oligoarticular JIA, and were antinuclear antibody (ANA)-positive, rheumatoid factor (RF)-negative, and anticitrullinated protein antibody-negative. Predictors of uveitis development included female sex, early age of arthritis onset, and oligoarticular JIA. Polyarticular RF-positive JIA subtype was protective. Nearly 3% of children with JIA-U were AA. However, of the 220 AA children with JIA, 6% had uveitis; in contrast, 12% of the 3721 NHW children with JIA had uveitis.
  
  
  CONCLUSIONS
  In the CARRA registry, the prevalence of JIA-U in AA and NHW children is 11.6%. We confirmed known uveitis risk markers (ANA positivity, younger age at arthritis onset, and oligoarticular JIA). We describe a decreased likelihood of uveitis in AA children and recommend further exploration of race as a risk factor in a larger population of AA children.
authors.affiliation: From the Department of Pediatrics, and Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Pediatric Rheumatology, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts; and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
authors.forename: Sheila T
authors.initials: ST
authors.lastname: Angeles-Han
authors.forename: Christina F
authors.initials: CF
authors.lastname: Pelajo
authors.forename: Larry B
authors.initials: LB
authors.lastname: Vogler
authors.forename: Kelly
authors.initials: K
authors.lastname: Rouster-Stevens
authors.forename: Christine
authors.initials: C
authors.lastname: Kennedy
authors.forename: Lori
authors.initials: L
authors.lastname: Ponder
authors.forename: Courtney
authors.initials: C
authors.lastname: McCracken
authors.forename: Jorge
authors.initials: J
authors.lastname: Lopez-Benitez
authors.forename: Carolyn
authors.initials: C
authors.lastname: Drews-Botsch
authors.forename: Sampath
authors.initials: S
authors.lastname: Prahalad
mesh_terms: D000293:Adolescent; D001741:Black or African American / Q000706:statistics & numerical data*; D017677:Age Distribution; D017668:Age of Onset; D001171:Arthritis, Juvenile / Q000208:ethnology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D011788:Quality of Life; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D014605:Uveitis / Q000208:ethnology*; D044465:White People / Q000706:statistics & numerical data*
keywords: JUVENILE IDIOPATHIC ARTHRITIS; OUTCOMES; RISK MARKERS; UVEITIS