title: Ganglioglioma of the spinal cord in neurofibromatosis type 1.
abstract: The oncologic involvement of the spinal cord in neurofibromatosis type 1 (NF1) is not a typical feature of the disease. Here, we present a case of ganglioglioma of the spinal cord in a child with NF1 and try to define if this tumor can be considered coincidental or not. A 4-year-old boy affected by NF1 was diagnosed with a spinal cord-enhancing tumor extending from C4 to D3, with a disappearance in the T2 MRI sequences of the cerebrospinal fluid signal. The patient underwent a subtotal resection. The pathological exam revealed a ganglioglioma. To the best of our knowledge, only 1 other case of spinal cord ganglioglioma has been described in an NF1 patient. We suggest considering ganglioglioma in the differential diagnosis of an NF1 patient with a spinal cord tumor due to its favorable survival rate, especially in relation to the anatomical and surgical issues of this tumor that do not always entail a gross total resection.
authors.affiliation: Clinica Neurochirurgica, Università degli Studi Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Giussani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Isimbaldi
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
authors.forename: Andrea
authors.initials: A
authors.lastname: Trezza
authors.forename: Paola
authors.initials: P
authors.lastname: Cianci
authors.forename: Francesco
authors.initials: F
authors.lastname: Canonico
authors.forename: Erik P
authors.initials: EP
authors.lastname: Sganzerla
mesh_terms: D001706:Biopsy; D002675:Child, Preschool; D018303:Ganglioglioma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013116:Spinal Cord / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery