title: Emphysema and mechanical stress-induced lung remodeling.
abstract: Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. We present possible new directions and an integrated multiscale view that may prove useful in finding solutions for this disease.
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
authors.forename: Béla
authors.initials: B
authors.lastname: Suki
authors.forename: Susumu
authors.initials: S
authors.lastname: Sato
authors.forename: Harikrishnan
authors.initials: H
authors.lastname: Parameswaran
authors.forename: Margit V
authors.initials: MV
authors.lastname: Szabari
authors.forename: Ayuko
authors.initials: A
authors.lastname: Takahashi
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Bartolák-Suki
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D018450:Disease Progression; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D040542:Mechanotransduction, Cellular; D011312:Pressure; D011379:Prognosis; D011656:Pulmonary Emphysema / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D013314:Stress, Mechanical