title: [Severe shock after protamine infusion in a neonate undergoing cardio pulmonary bypass].
abstract: Shock after protamine infusion are rare. We report here the case of a 6-day-old boy having presented severe and recurring hypotensions after protamine infusions during cardiac surgery under cardio pulmonary bypass. The physiopathology of these reactions is complex and, in the presented case, involved mechanism may not be anaphylactic.
authors.affiliation: Unité de réanimation pédiatrique, pôle Femme-Enfant-Adolescent, CHU de Nantes, 38, boulevard Jean-Monnet, 44093 Nantes, France. Electronic address: nicolas.joram@chu-nantes.fr.
authors.forename: N
authors.initials: N
authors.lastname: Joram
authors.forename: N
authors.initials: N
authors.lastname: Benbrik
authors.forename: A
authors.initials: A
authors.lastname: De Windt
authors.forename: H
authors.initials: H
authors.lastname: Colas
authors.forename: J M
authors.initials: JM
authors.lastname: Liet
mesh_terms: D002315:Cardiopulmonary Bypass; D017809:Fatal Outcome; D006494:Heparin Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006632:Histamine / Q000097:blood; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D011296:Prenatal Diagnosis; D011479:Protamines / Q000008:administration & dosage / Q000009:adverse effects*; D012769:Shock / Q000139:chemically induced* / Q000503:physiopathology; D014188:Transposition of Great Vessels / Q000601:surgery
chemical_list: D006494:Heparin Antagonists; D011479:Protamines; D006632:Histamine
keywords: Choc; Neonate; Nouveau-né; Protamine; Shock