title: Induction by fructose force-feeding of histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and its expression in mice.
abstract: It has been reported that fructose force-feeding rapidly induced jejunal Slc2a5 gene expression in rodents. We demonstrate in this study that acetylation at lysine (K) 9 of histone H3 and acetylation at K5 and K16 of histone H4 were more enhanced in the promoter/enhancer to transcribed regions of the Slc2a5 gene in fructose force-fed mice than in glucose force-fed mice. However, fructose force-feeding did not induce acetylation at K14 of histone H3, or at K8 and K12 of histone H4 around the Slc2a5 gene. These results suggest that fructose force-feeding induced selective histone acetylation, particularly of H3 and H4, around the jejunal Slc2a5 gene in mice.
authors.affiliation: Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences.
authors.forename: Kazue
authors.initials: K
authors.lastname: Honma
authors.forename: Kazuki
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
mesh_terms: D000107:Acetylation; D000284:Administration, Oral; D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism*; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism*; D015870:Gene Expression; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism*; D051296:Glucose Transporter Type 5; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008239:Lysine / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational
chemical_list: D004040:Dietary Carbohydrates; D051246:Glucose Transport Proteins, Facilitative; D051296:Glucose Transporter Type 5; D006657:Histones; C465351:Slc2a5 protein, mouse; D005632:Fructose; D005947:Glucose; D008239:Lysine