title: Validation of the consensus methodology algorithm for the classification of systemic necrotizing vasculitis in Indian patients.
abstract: OBJECTIVE
  Many patients with systemic necrotizing vasculitis (SNV) satisfy classification criteria of different disease entities when different classification systems are used. A new classification algorithm has been proposed recently by using the American College of Rheumatology criteria, Chapel Hill Consensus Criteria (CHCC) and Sorensen surrogate markers for a more uniform classification of patients suffering from these rare disorders.
  
  
  METHODS
  We applied this algorithm to patients diagnosed as having systemic vasculitis between 2007 and 2011. We also analyzed the data using this algorithm by incorporating the recently proposed revised CHCC nomenclature of vasculitis in place of the older criteria.
  
  
  RESULTS
  Seventy-nine patients with SNV were studied. One patient diagnosed as microscopic polyangiitis (MPA) had to be excluded from analysis as she had previously been diagnosed as having Behcet's disease. All patients of eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA) and MPA were reclassified to the same diagnostic subcategory after application of the algorithm. Three (16.7%) of 18 polyarteritis nodosa patients were unclassifiable after application of the consensus algorithm while two (11.1%) were reclassified as MPA. All previously unclassifiable patients could be classified either as MPA or GPA after application of the new algorithm. There was no difference in the results when the CHCC 2012 nomenclature was used instead of the older CHCC in the consensus algorithm.
  
  
  CONCLUSIONS
  The new classification algorithm is a reliable method for classification of SNV for epidemiological purposes in our population.
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.forename: Tarun
authors.initials: T
authors.lastname: Mittal
authors.forename: Roopa
authors.initials: R
authors.lastname: Rajan
authors.forename: Manish
authors.initials: M
authors.lastname: Rathi
authors.forename: Ritambhra
authors.initials: R
authors.lastname: Nada
authors.forename: Ranjana W
authors.initials: RW
authors.lastname: Minz
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
authors.forename: Vinay
authors.initials: V
authors.lastname: Sakhuja
authors.forename: Surjit
authors.initials: S
authors.lastname: Singh
mesh_terms: D000465:Algorithms; D015267:Churg-Strauss Syndrome / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D032921:Consensus; D003951:Diagnostic Errors / Q000517:prevention & control; D014890:Granulomatosis with Polyangiitis / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D055953:Microscopic Polyangiitis / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D010488:Polyarteritis Nodosa / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D056647:Systemic Vasculitis / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D009626:Terminology as Topic
keywords: Indian; classification criteria; consensus methodology algorithm; diagnostic criteria; vasculitis