title: Multiple cytokines-producing pleomorphic carcinoma of lung with metastasis to the small intestine.
abstract: A 58-year-old man underwent upper lobectomy for primary pleomorphic carcinoma of the lung. Nine months later, the pleomorphic carcinoma was recurred with marked peripheral leukocytosis and an elevated C-reactive protein. Chest and abdominal computed tomography (CT) revealed enlarged mediastinal lymph nodes and a bulky tumor in the small intestine. An enterectomy was performed and the intestinal tumor was removed. Immunostaining revealed tumor cells positive for G-CSF and TNF-α as well as an increased level of serum G-CSF and TNF-α. We describe a rare case of G-CSF and TNF-α producing pleomorphic carcinoma of the lung with metastasis to the small intestine.
authors.affiliation: Respiratory Division, Department of Internal Medicine, Itami City Hospital, Hyogo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hara
authors.forename: Keita
authors.initials: K
authors.lastname: Hosoi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Suga
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Degami
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kyongyob
authors.initials: K
authors.lastname: Min
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism* / Q000556:secondary / Q000601:surgery*; D007421:Intestine, Small; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D011013:Pneumonectomy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor; D002097:C-Reactive Protein