title: Towards Tartaric-Acid-Derived Asymmetric Organocatalysts.
abstract: Tartaric acid is one of the most prominent naturally occurring chiral compounds. Whereas its application in the production of chiral ligands for metal-catalysed reactions has been exhaustively investigated, its potential to provide new organocatalysts has been less extensively explored. Nevertheless, some impressive results, such as the use of TADDOLs as chiral H-bonding catalysts or of tartrate-derived asymmetric quaternary ammonium salt catalysts, have been reported over the last decade. The goal of this article is to provide a representative overview of the potential and the limitations of tartaric acid or TADDOLs in the creation of new organocatalysts and to highlight some of the most spectacular applications of these catalysts, as well as to summarize case studies in which other classes of chiral backbones were better suited.
authors.affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz Altenbergerstraße 69, 4040 Linz, Austria, http://www.orc.jku.at/mwaser.
authors.forename: Katharina
authors.initials: K
authors.lastname: Gratzer
authors.forename: Guddeangadi N
authors.initials: GN
authors.lastname: Gururaja
authors.forename: Mario
authors.initials: M
authors.lastname: Waser
keywords: Asymmetric catalysis; Chiral Lewis bases; Chiral pool; H-bonding catalysis; Phase-transfer catalysis; TADDOLs