title: The research of nanoparticles as gene vector for tumor gene therapy.
abstract: With the development of molecular biology, the application of the gene therapy becomes a tendency in the development of oncotherapy. The gene therapy has been acknowledged as the major progress of modern medicine, also a focus in the oncotherapy research. Commonly vectors of the gene therapy mainly include two categories, namely, viral vectors and nonviral vectors. Nanoparticles gene vector of various different kinds of materials, which belong to non-viral carriers. It presents excellent abilities of adsorption, concentration and protection of DNA, which can be attributed as a main reason of the adsorption and operation of nano-gene vector on exogenous genes. In this article, we mainly reviewed the recent studies of the characteristics of nanoparticles, characteristics and transport mechanism of nanoparticles as gene vector, the progress on nanoparticles as gene vector in tumor gene therapy. Nano-gene vectors, as new drug and gene carriers, present characteristics such as the controlled-release, targeting, and the improvement of bioavailability. Nanoparticles for cancer imaging and therapy have evolved rapidly during the last decade and it is expected that more and more will become clinical practise. In the near future, as a new nanometer gene delivery vector will be in medical research and treatment play a bigger role.
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China; Department of the Surgery, Affiliated Jinan Central Hospital of Shandong University, Jinan 250013, China.
authors.forename: Nian-feng
authors.initials: NF
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China; Department of the Surgery, Affiliated Jinan Central Hospital of Shandong University, Jinan 250013, China.
authors.forename: Zhan-ao
authors.initials: ZA
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China; Department of the Surgery, Affiliated Jinan Central Hospital of Shandong University, Jinan 250013, China.
authors.forename: Wen-bai
authors.initials: WB
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China; Department of the Surgery, Affiliated Jinan Central Hospital of Shandong University, Jinan 250013, China.
authors.forename: Ai-ling
authors.initials: AL
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address: sanyuanhu2013@sina.cn.
authors.forename: San-yuan
authors.initials: SY
authors.lastname: Hu
mesh_terms: D015316:Genetic Therapy; D005822:Genetic Vectors; D006046:Gold / Q000737:chemistry; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*
chemical_list: D006046:Gold
keywords: Gene vectors; Nanoparticles; Transfection efficiency; Tumor