title: Bromoform activation. TiCl4-Mg-promoted CHBr2- and CBr3- transfer to a variety of aldehydes and ketones.
abstract: TiCl4-Mg can mediate addition of CHBr3 to a variety of aldehydes and ketones to form dibromomethyl carbinols and also be used to effect CBr3 transfer to carbonyl groups to form tribromomethyl carbinols. The successful application of TiCl4-Mg-promoted coupling of CHBr3 with various carbonyl compounds, especially in the case of highly enolizable ketones such as 2-indanone and β-tetralone, highlights the extraordinary reactivity and selectivity and the weakly basic nature of this system.
authors.affiliation: Department of Chemistry, National Chung-Hsing University , Taichung 400, Taiwan, Republic of China.
authors.forename: Tu-Hsin
authors.initials: TH
authors.lastname: Yan
authors.forename: Su-Haur
authors.initials: SH
authors.lastname: Chang
authors.forename: Cheng-Ta
authors.initials: CT
authors.lastname: Chang
authors.forename: Chia-Kuan
authors.initials: CK
authors.lastname: Lin
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Liu