title: Influence of starting material particle size on pellet surface roughness.
abstract: The purpose of this study was to investigate the effect of pelletization aids, i.e., microcrystalline cellulose (MCC) and cross-linked polyvinyl pyrrolidone (XPVP), and filler, i.e., lactose, particle size on the surface roughness of pellets. Pellets were prepared from powder blends containing pelletization aid/lactose in 1:3 ratio by extrusion-spheronization. Surface roughness of pellets was assessed quantitatively and qualitatively using optical interferometry and scanning electron microscopy, respectively. Both quantitative and qualitative surface studies showed that surface roughness of pellets depended on the particle size of XPVP and lactose used in the formulation. Increase in XPVP or lactose particle size resulted in rougher pellets. Formulations containing MCC produced pellets with smoother surfaces than those containing XPVP. Furthermore, surface roughness of the resultant pellets did not appear to depend on MCC particle size. Starting material particle size was found to be a critical factor for determining the surface roughness of pellets produced by extrusion-spheronization. Smaller particles can pack well with lower peaks and valleys, resulting in pellets with smoother surfaces. Similar surface roughness of pellets containing different MCC grades could be due to the deaggregation of MCC particles into smaller subunits with more or less similar sizes during wet processing. Hence, for starting materials that deaggregate during the wet processing, pellet surface roughness is influenced by the particle size of the material upon deaggregation.
authors.affiliation: GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, Singapore, 117543, Singapore.
authors.forename: Srimanta
authors.initials: S
authors.lastname: Sarkar
authors.forename: Bee Hwee
authors.initials: BH
authors.lastname: Ang
authors.forename: Celine Valeria
authors.initials: CV
authors.lastname: Liew
mesh_terms: D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D004343:Drug Implants / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D010316:Particle Size; D011205:Povidone / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004343:Drug Implants; D005079:Excipients; D011208:Powders; D002482:Cellulose; D011205:Povidone; D007785:Lactose; C109691:microcrystalline cellulose