title: Screening of longevity-associated genes based on a comparison between dead and surviving populations.
abstract: OBJECTIVE
  To investigate longevity-associated genes based on a comparison between dead and surviving populations.
  
  
  METHODS
  A total of 71 cases of dead individuals were treated as the death group, and healthy volunteers who were matched with the dead individuals based on sex and age were recruited as the survival group. Alleles of 13 CODIS STR loci were determined using the AmpFLSTR Profiler Plus PCR Amplification Kit. The cross-validation was performed based on differences between the two groups in both frequency values and ages.
  
  
  RESULTS
  The frequency value of the D18S51-17 alleles was significantly higher in the dead group than in the survival group (p<0.05), and the frequency value of the D2S1338-18 allele was statistically lower in the dead group than in the survival group (p<0.05). The mean age of the subjects with the D2S1338-18 allele was also significantly higher than that of the subjects without D2S1338-18, and no significant difference was observed with respect to the other three alleles.
  
  
  CONCLUSIONS
  The results suggest that D2S1338-18 is associated with longevity.
authors.affiliation: Dalian Blood Center, China; College of Medical Laboratory, Dalian Medical University, China.
authors.forename: Wanxin
authors.initials: W
authors.lastname: An
authors.affiliation: Dalian Blood Center, China; College of Medical Laboratory, Dalian Medical University, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Dalian Blood Center, China; College of Medical Laboratory, Dalian Medical University, China.
authors.forename: Benlan
authors.initials: B
authors.lastname: Gong
authors.affiliation: Dalian Blood Center, China.
authors.forename: Sashuang
authors.initials: S
authors.lastname: Ren
authors.affiliation: Dalian Blood Center, China. Electronic address: liuhui60@sina.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population / Q000379:methods; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male
keywords: CODIS; DNA; Heredity; ICU; Longevity; STR; deoxyribonucleic acid; intensive care unit; short tandem repeats; the U.S. national Combined DNA Indexing System