title: Impact of -455G/a polymorphism of the β-fibrinogen gene on platelet aggregation in patients with acute coronary syndrome.
abstract: We aimed to investigate the association of aspirin and/or clopidogrel low response with -455G/A polymorphism of β-fibrinogen in patients with acute coronary syndrome (ACS). We enrolled 114 consecutive patients (mean age 61 ± 7, 31 female [27.2%], 83 male [72.8%]) with a first ACS. The diagnostic criteria for ACS were based on current guidelines. The -455 G/A β-fibrinogen polymorphism genotype distribution in the patient group was determined as the following: 54.4% GG homozygote, 39.5% GA, and 6.1% AA homozygote. Clopidogrel low response was present in 25 (21.9%) patients, aspirin low response in 21 (18.4%) patients, and dual antiplatelet low response in 9 (7.9%) patients. In our study, no difference was observed in terms of the distribution of -455 G/A β-fibrinogen polymorphism between the groups with and without aspirin and/or clopidogrel or dual antiplatelet low response in the patient group who underwent aspirin and clopidogrel treatment for ACS (P > .05).
authors.affiliation: 1Department of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Sevimli
authors.forename: Suleyman
authors.initials: S
authors.lastname: Karakoyun
authors.forename: Eftal Murat
authors.initials: EM
authors.lastname: Bakirci
authors.forename: Selim
authors.initials: S
authors.lastname: Topcu
authors.forename: Kamuran
authors.initials: K
authors.lastname: Kalkan
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Borekci
authors.forename: Serhat
authors.initials: S
authors.lastname: Vançelik
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D001241:Aspirin / Q000008:administration & dosage*; D000077144:Clopidogrel; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects* / Q000235:genetics*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D005340:Fibrinogen; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
keywords: acute coronary syndromes; antiplatelet drugs; gene polymorphisms