title: Hyptis suaveolens (L.) Poit (Lamiaceae), a medicinal plant protects the stomach against several gastric ulcer models.
abstract: BACKGROUND
  Hyptis suaveolens is used by the traditional population in several parts of the world to treat inflammation, gastric ulcer and infection and is used as a crude drug to relieve symptoms related with gastric ulcer or gastritis in northeaster and central region of Brazil.
  
  
  METHODS
  the standardized ethanolic extract (Hs-EtOHE) and hexanic fraction (Hs-HexF) of Hyptis suaveolens (62,5, 125, 250 and 500 mg/kg) was evaluated in several models of acute gastric ulcers. The participation of NO was evaluated by pretreatment with L-NAME and non-protein sulfyhydryls by NEM in the gastroprotective effect.
  
  
  RESULTS
  Hs-EtOHE and Hs-HexF markedly reduced the gastric lesions induced by all ulcerogenic agents (HCl/ethanol, ethanol, NSAIDs and hypothermic restraint-stress). Gastric ulcerations were exacerbated by administration of NEM suggesting that the gastroprotective mechanism of action of Hs-EtOHE and Hs-HexF involves sulfhydryl groups.
  
  
  CONCLUSIONS
  Ours results show that an extract of Hyptis suaveolens, administered orally to rodents, present gastro protective activity in different models of acute of gastric ulcer and give some support to the reported claims on the use of this plant as a gastro protective agent.
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba (UFPB), 58051-970 João Pessoa, PB, Brazil.
authors.forename: N Z T
authors.initials: NZ
authors.lastname: Jesus
authors.forename: H S
authors.initials: HS
authors.lastname: Falcão
authors.forename: G R M
authors.initials: GR
authors.lastname: Lima
authors.forename: M R D
authors.initials: MR
authors.lastname: Caldas Filho
authors.forename: I R P
authors.initials: IR
authors.lastname: Sales
authors.forename: I F
authors.initials: IF
authors.lastname: Gomes
authors.forename: S G
authors.initials: SG
authors.lastname: Santos
authors.forename: J F
authors.initials: JF
authors.lastname: Tavares
authors.forename: J M
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: L M
authors.initials: LM
authors.lastname: Batista
mesh_terms: D000818:Animals; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006851:Hydrochloric Acid; D031331:Hyptis; D008026:Ligation; D008297:Male; D008517:Phytotherapy; D010894:Piroxicam; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D010894:Piroxicam; D000431:Ethanol; D006851:Hydrochloric Acid
keywords: Gastroprotective; Hs-DCMF; Hs-EAF; Hs-EtOHE; Hs-HexF; Hyptis suaveolens; L-NAME; Lamiaceae; N-ethylmaleimide; NEM; NO; NSAIDs; Peptic ulcer; dicloromethanic fraction Hyptis suaveolens; ethanolic extract Hyptis suaveolens; ethil acetate fraction; hexanic fraction Hyptis suaveolens; l-nitro-l-arginine methyl ester; nitric oxide; non-steroidal anti-inflammatory drugs