title: Urea transporter inhibitors: en route to new diuretics.
abstract: A selective urea transporter UT-A1 inhibitor would be a novel type of diuretic, likely with less undesirable side effects than conventional diuretics, because it acts on the last portion of the nephron. In this issue of Chemistry & Biology, Esteva-Font and colleagues develop such an inhibitor by using a clever high-throughput screening assay and document its selectivity.
authors.affiliation: Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: jeff.sands@emory.edu.
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Sands
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D026901:Membrane Transport Proteins / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000032:analysis* / Q000494:pharmacology*; D000096982:Urea Transporters
chemical_list: D026901:Membrane Transport Proteins; D054852:Small Molecule Libraries; D000096982:Urea Transporters