title: Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease.
abstract: Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be identified and will need to be addressed by dedicated studies of clinical utility.
authors.affiliation: Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Belgium ; Neurology Department, University Hospitals Leuven, Belgium ; Alzheimer Research Centre KU Leuven, Leuven Institute of Neuroscience and Disease, University of Leuven, Belgium.
authors.forename: Rik
authors.initials: R
authors.lastname: Vandenberghe
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Adamczuk
authors.forename: Patrick
authors.initials: P
authors.lastname: Dupont
authors.forename: Koen Van
authors.initials: KV
authors.lastname: Laere
authors.forename: Gaël
authors.initials: G
authors.lastname: Chételat
keywords: Clinic; Diagnostic; Florbetaben; Florbetapir; Flutemetamol; PIB