title: Gold(I)-catalyzed 6-endo hydroxycyclization of 7-substituted-1,6-enynes.
abstract: The cyclization of o-(alkynyl)-3-(methylbut-2-enyl)benzenes, 1,6-enynes having a condensed aromatic ring at C3-C4 positions, has been studied under the catalysis of cationic gold(I) complexes. The selective 6-endo-dig mode of cyclization observed for the 7-substituted substrates in the presence of water or methanol giving rise to hydroxy(methoxy)-functionalized dihydronaphthalene derivatives is highly remarkable in the context of the observed reaction pathways for the cycloisomerizations of 1,6-enynes bearing a trisubstituted olefin.
authors.affiliation: Área de Química Orgánica, Departamento de Química, Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos s/n, 09001 Burgos, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sanjuán
authors.forename: Alberto
authors.initials: A
authors.lastname: Martínez
authors.forename: Patricia
authors.initials: P
authors.lastname: García-García
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Fernández-Rodríguez
authors.forename: Roberto
authors.initials: R
authors.lastname: Sanz
keywords: catalysis; dihydronaphthalenes; gold; gold catalysis; hydroxycyclization; selectivity