title: Transcriptional regulation of the survivin gene.
abstract: Survivin, a small member of the inhibitors of the apoptosis protein family, is highly deregulated in cancer. It is weakly expressed in normal tissues but very strongly expressed in malignant lesions. Survivin is involved in cell-cycle progression, especially in the G2/M transition, and has anti-apoptotic activity, which correlates with its strong expression in cases with a poor cancer treatment response and poor outcomes. Several therapies that target the survivin transcript or protein are currently being tested in clinical trials. However, focusing new therapies on the origins of survivin overexpression and targeting these upstream deregulations could be more effective. For this reason, it seems important to make an inventory of the transcriptional (de)regulation of survivin. This review will gather the important points concerning the regulation of survivin mRNA expression: structure of the survivin promoter, epigenetic modifications and genetic abnormalities, transcription factors, and signalling pathways that affect survivin mRNA expression.
authors.affiliation: Unit of Molecular Biology, Centre Georges-François Leclerc, 1, rue du Professeur Marion, 21079, Dijon Cedex, France, rboidot@cgfl.fr.
authors.forename: Romain
authors.initials: R
authors.lastname: Boidot
authors.forename: Frédérique
authors.initials: F
authors.lastname: Végran
authors.forename: Sarab
authors.initials: S
authors.lastname: Lizard-Nacol
mesh_terms: D001483:Base Sequence; D049109:Cell Proliferation; D002470:Cell Survival; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D000077022:Survivin; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D014157:Transcription Factors