title: Intrinsic radio-sensitivity of tumours to low let radiations: a mathematical model in LQ formalism.
abstract: Intrinsic radio-sensitivity is the determinant of differential response of tumours to low LET ionising radiations. The probabilistic DNA fibril both model shows intrinsic radio-sensitivity factor [I] as function of nuclear diameter (Nd) and intra cellular hydrogen ion concentration [H+]. Linking probabilities of lethal and sub-lethal events to [I] further results in equations which show the LQ parameters namely alpha and beta are functions of (Nd), [H+] and repair constant (μ) mu. This model is able to explain radiobiological phenomena of OER and Do value of lymphocytes.
authors.affiliation: Radiation Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India. Electronic address: amamayas78@gmail.com.
authors.forename: Sk Ayasuddin
authors.initials: SA
authors.lastname: Mohammed
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018499:Linear Energy Transfer / Q000502:physiology*; D008214:Lymphocytes / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism; D011836:Radiation Tolerance / Q000502:physiology*; D011839:Radiation, Ionizing
chemical_list: D010100:Oxygen