title: Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice.
abstract: Apolipoprotein F is a component protein mainly secreted by liver and resides on several lipoprotein classes. It can inhibit lipids transfer between different lipoproteins. FXR is a member of the nuclear receptor superfamily which is also highly expressed in the liver. It modulates bile acids synthesis and lipids metabolism by transcriptional regulation. We aimed to determine whether apoF can be regulated by FXR. The FXR agonist Chenodeoxycholic acid (CDCA) and GW4064 both can activate the expression of apoF in liver cell lines and in C57/BL6 mouse liver. This is dependent on the binding of FXR to the FXR element ER1 (-2904 to -2892 bp) in the apoF gene promoter. Taken together, we have identified apoF as likely another target gene of FXR.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Third Military Medical University, Chongqing 400038, China.
authors.forename: Liangpeng
authors.initials: L
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Jiahe
authors.initials: J
authors.lastname: Peng
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jinyu
authors.initials: J
authors.lastname: Dong
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000235:genetics*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D005786:Gene Expression Regulation; D056945:Hep G2 Cells; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011401:Promoter Regions, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000378:metabolism*; D015854:Up-Regulation; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001053:Apolipoproteins; D002635:Chenodeoxycholic Acid; D007555:Isoxazoles; D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated; C036321:apolipoprotein F; C412815:GW 4064
keywords: Apolipoprotein F; CETP; Chenodeoxycholic acid; Cholesterol ester transfer protein; FXR; High density lipoprotein; Low density lipoprotein; apoF; apolipoprotein F; cholesterol ester transfer protein; farnesoid X receptor