title: [Biotechnological therapies for the treatment of back pain: alternatives to corticosteroids].
abstract: In recent years, it is increasingly clear that back pain is not only caused by biomechanical problems. Currently, biologically-based local therapy concepts for the treatment of affected spinal regions as an alternative to the standard treatment with steroids are in development or in early stages of clinical application. The common features of these new therapies are to intervene in the regulation of homeostasis at various key points at the affected region and specifically to suppress or block catabolic influences as well as to provide with anti-inflammatory substances and growth factors. These include on one hand the genetically produced Biologicals such as TNF-α inhibitors and cytokine antagonists and on the other hand therapies with autologous blood preparations (Autologous Conditioned Serum [ACS], and Platelet Rich Plasma formulations [PRP]). This article presents the individual methods, gives an overview of developments and results of various studies and discusses current recommendations.
authors.affiliation: Grönemeyer Institut für Mikrotherapie; Lehrstuhl für Radiologie und Mikrotherapie, Universität Witten/Herdecke, Universitätsstr. 142, 44799, Bochum, Deutschland, moser@microtherapy.de.
authors.forename: C
authors.initials: C
authors.lastname: Moser
authors.forename: H-J
authors.initials: HJ
authors.lastname: Thiel
authors.forename: D
authors.initials: D
authors.lastname: Grönemeyer
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001416:Back Pain / Q000188:drug therapy*; D001688:Biological Products / Q000627:therapeutic use*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D015195:Drug Design; D019317:Evidence-Based Medicine; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D001688:Biological Products; D036341:Intercellular Signaling Peptides and Proteins