title: Alterations in the size of the poly(a) segment in newly-synthesized messenger RNA of mouse sarcoma 180 ascites cells.
abstract: The size of the poly(A) segment present at the 3'-end of mRNA molecules decreases gradually after entry of the mRNA into the cytoplasm. The size reduction seems to occur equally in free and polysome-bound mRNA. It is not affected by conditions that inhibit protein synthesis, such as treatment with cycloheximide and amino acid deprivation. The latter condition leads to a substantial increase in the size of nuclear poly(A). The rate of poly(A) cleavage could determine the length of time a mRNA molecule remains functional in the cytoplasm.
authors.affiliation: Department of Biochemistry and Pharmacology, Tufts University School of Medicine, 02111, Boston, Mass, USA.
authors.forename: G
authors.initials: G
authors.lastname: Brawerman