title: Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems.
abstract: Novel hybrid nanomaterials have been developed for antimicrobial applications. Here we introduce a green route to produce antibacterial nanofiber mats loaded with silver nanoparticles (Ag-NPs, 25 nm diameter) enveloped in chitosan after reduction with glucose. The nanofiber mats were obtained from colloidal dispersions of chitosan-based Ag-NPs blended with polyvinyl alcohol. Nanofibers (150 nm average diameter and narrow size distribution) were obtained by electrospinning and cross-linked with glutaraldhyde. The effect of crosslinking on the release of silver was studied by atomic absorption spectroscopy. Antimicrobial activity was studied by the viable cell-counting; mats loaded with silver and control samples (chitosan/PVA) with different degrees of cross-linking were compared for their effectiveness in reducing or halting the growth of aerobic bacteria. The results showed superior properties and synergistic antibacterial effects by combining chitosan with Ag-NPs.
authors.affiliation: Fiber and Polymer Science Program, College of Textiles, North Carolina State University, Campus Box 8301, NC, USA. Electronic address: aabdelg@ncsu.edu.
authors.forename: Abdelrahman M
authors.initials: AM
authors.lastname: Abdelgawad
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Hudson
authors.forename: Orlando J
authors.initials: OJ
authors.lastname: Rojas
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001458:Bandages / Q000382:microbiology*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D005947:Glucose / Q000737:chemistry; D055772:Green Chemistry Technology; D053768:Metal Nanoparticles / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D019163:Reducing Agents / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry; D013696:Temperature; D014947:Wounds and Injuries
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D019163:Reducing Agents; D012834:Silver; D011142:Polyvinyl Alcohol; D048271:Chitosan; D012835:Silver Nitrate; D005947:Glucose
keywords: Antimicrobial; Chitosan; Electrospinning; Polyvinyl alcohol; Silver nanoparticles