title: Memory consolidation of fear conditioning: bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex.
abstract: Investigations of fear conditioning in rodents and humans have illuminated the neural mechanisms of fear acquisition and extinction. However, the neural mechanism of memory consolidation of fear conditioning is not well understood. To address this question, we measured brain activity and the changes in functional connectivity following fear acquisition using resting-state functional magnetic resonance imaging. The amygdala-dorsal anterior cingulate cortex (dACC) and hippocampus-insula functional connectivity were enhanced, whereas the amygdala-medial prefrontal cortex (mPFC) functional coupling was decreased during fear memory consolidation. Furthermore, the amygdala-mPFC functional connectivity was negatively correlated with the subjective fear ratings. These findings suggest the amygdala functional connectivity with dACC and mPFC may play an important role in memory consolidation of fear conditioning. The change of amygdala-mPFC functional connectivity could predict the subjective fear. Accordingly, this study provides a new perspective for understanding fear memory consolidation.
authors.affiliation: School of Psychology, Southwest University, Chongqing, China, and Key Laboratory of Cognition and Personality, Ministry of Education.
authors.forename: Pan
authors.initials: P
authors.lastname: Feng
authors.affiliation: School of Psychology, Southwest University, Chongqing, China, and Key Laboratory of Cognition and Personality, Ministry of Education School of Psychology, Southwest University, Chongqing, China, and Key Laboratory of Cognition and Personality, Ministry of Education fengty0@163.com.
authors.forename: Tingyong
authors.initials: T
authors.lastname: Feng
authors.affiliation: School of Psychology, Southwest University, Chongqing, China, and Key Laboratory of Cognition and Personality, Ministry of Education.
authors.forename: Zhencai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: School of Psychology, Southwest University, Chongqing, China, and Key Laboratory of Cognition and Personality, Ministry of Education.
authors.forename: Xu
authors.initials: X
authors.lastname: Lei
mesh_terms: D000679:Amygdala / Q000098:blood supply / Q000473:pathology*; D001007:Anxiety / Q000175:diagnosis / Q000473:pathology; D001931:Brain Mapping; D003214:Conditioning, Classical; D005239:Fear; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D012146:Rest; D013997:Time Factors; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: amygdala; fear memory consolidation; functional connectivity; resting-state fMRI