title: Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp.
abstract: By means of bioassay-guided fractionation, a new steroidal alkaloid, plakinamine M (1), and the known compound, plakinamine L (2), with a unique acyclic side chain, were isolated from the marine sponge Corticium sp. collected from New Britain, Papua New Guinea. The structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The two compounds showed inhibition of Mycobacterium tuberculosis with MIC values of 15.8 and 3.6 μg/mL, respectively.
authors.affiliation: Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Lu
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: Teatulohi K
authors.initials: TK
authors.lastname: Matainaho
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Van Wagoner
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006113:United Kingdom
chemical_list: D000470:Alkaloids; D013256:Steroids; C548387:plakinamine L; C586141:plakinamine M