title: Stereoselective synthesis of the C79-C97 fragment of symbiodinolide.
abstract: Symbiodinolide is a polyol marine natural product with a molecular weight of 2860. Herein, a streamlined synthesis of the C79-C97 fragment of symbiodinolide is described. In the synthetic route, a spiroacetalization, a Julia-Kocienski olefination, and a Sharpless asymmetric dihydroxylation were utilized as the key transformations.
authors.affiliation: Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Takamura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Isao
authors.initials: I
authors.lastname: Kadota
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
keywords: Julia–Kocienski olefination; Sharpless asymmetric dihydroxylation; polyol marine natural product; spiroacetalization; symbiodinolide