title: Chemoprevention of prostate cancer.
abstract: Large prospective randomized trials, such as the Prostate Cancer Prevention Trial (PCPT), Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, and Selenium and Vitamin E Cancer Prevention Trial (SELECT), have provided practitioners with considerable data regarding methods of treatment and prevention of prostate cancer. The best-studied medications for prevention are 5 alpha-reductase inhibitors. Their efficacy and side effects are well characterized. Other medications, dietary nutrients, and supplements have not been as well studied and generally do not demonstrate efficacy for disease prevention with an acceptable level of evidence.
authors.affiliation: Division of Urologic Surgery, Washington University School of Medicine in St. Louis, Siteman Cancer Center, St. Louis, Missouri; email: vemanag@wudosis.wustl.edu ; andrioleg@wustl.edu.
authors.forename: Goutham
authors.initials: G
authors.lastname: Vemana
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hamilton
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Andriole
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Freedland
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001378:Azasteroids / Q000627:therapeutic use; D002338:Carotenoids / Q000627:therapeutic use; D019587:Dietary Supplements; D000068538:Dutasteride; D018120:Finasteride / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008019:Life Style; D000077276:Lycopene; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D011322:Primary Prevention; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D012643:Selenium / Q000627:therapeutic use; D028024:Serenoa; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D058891:5-alpha Reductase Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001378:Azasteroids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010936:Plant Extracts; D020845:Selective Estrogen Receptor Modulators; D014810:Vitamin E; D002338:Carotenoids; D018120:Finasteride; D012643:Selenium; C040972:saw palmetto extract; D000068538:Dutasteride; D000077276:Lycopene