title: Effect of vitamin C dietary supplementation in reducing the alterations induced by fenitrothion in Oreochromis niloticus.
abstract: The objective of this study was to investigate the dietary effect of vitamin C in amelioration some of studied alterations induced by fenitrothion in Nile tilapia (Oreochromis niloticus). Nile tilapia was exposed to sub-lethal concentration of fenitrothion 0.04 mg/l (96 h LC50 value was 0.8 mg/l), and basal diet was supplemented with two different dose of vitamin C (500 and 1200 mg/kg B wt/day) for 30 days. Vitamin C supplemented groups showed significant decrease in plasma cortisol and glucose level, enzymes activity of liver and gills (catalase, glutathione-S-transferase and superoxide dismutase) and % of tail DNA damage compared to exposed group. Moreover, fish revealed significant increase in total plasma protein, albumin, globulin and A/G ratio. High dose of vitamin C dietary supplementation (1200 mg/kg B wt/day) returns these parameters to its normal levels with no significant difference compared to non exposed control group. These results indicated that incorporation of high dose of vitamin C (1200 mg) in aqua feed for 30 days could be potentially less expensive and effective in reducing the alterations induced by fenitrothion in Nile tilapia.
authors.affiliation: Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Kalubia, 13736, Egypt, dreman_2010@yahoo.com.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Abd El-Gawad
authors.forename: Omnia M
authors.initials: OM
authors.lastname: Abdel Hamid
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D023681:Cichlids; D019587:Dietary Supplements; D005278:Fenitrothion / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D062025:Organophosphate Poisoning / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D001205:Ascorbic Acid; D005278:Fenitrothion