title: Sin3: insight into its transcription regulatory functions.
abstract: Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key biological processes. Knockdown studies have confirmed the role of Sin3 in cellular proliferation, differentiation, apoptosis and cell cycle regulation, emphasizing Sin3 as an essential regulator of critical cellular events in normal and pathological processes. The present review covers the diverse functions of this master transcriptional regulator as well as illustrates the redundant and distinct functions of its two mammalian isoforms.
authors.affiliation: Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India. Electronic address: ramakadamb@gmail.com.
authors.forename: Rama
authors.initials: R
authors.lastname: Kadamb
authors.forename: Shilpi
authors.initials: S
authors.lastname: Mittal
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bansal
authors.forename: Harish
authors.initials: H
authors.lastname: Batra
authors.forename: Daman
authors.initials: D
authors.lastname: Saluja
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004795:Enzyme Stability; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D056264:Sin3 Histone Deacetylase and Corepressor Complex / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D005656:Fungal Proteins; D006657:Histones; D020033:Protein Isoforms; D012097:Repressor Proteins; C099683:SIN3A transcription factor; C492042:SIN3B protein, human; D056264:Sin3 Histone Deacetylase and Corepressor Complex
keywords: Co-repressor complex; Histone deacetylase; Protein stability; Sin3A; Sin3B; Transcriptional regulation