title: Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy.
abstract: Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.
authors.affiliation: Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry Cedex, France. julien.nicolas@u-psud.fr.
authors.forename: Duc Trung
authors.initials: DT
authors.lastname: Bui
authors.forename: Julien
authors.initials: J
authors.lastname: Nicolas
authors.forename: Andrei
authors.initials: A
authors.lastname: Maksimenko
authors.forename: Didier
authors.initials: D
authors.lastname: Desmaële
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D011355:Prodrugs / Q000627:therapeutic use*; D013185:Squalene / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D003841:Deoxycytidine; D013185:Squalene; D000093542:Gemcitabine