title: [Focused ultrasound therapy: current status and potential applications in neurosurgery].
abstract: High Intensity Focused Ultrasound (HIFU) therapy is an innovative approach for tissue ablation, based on high intensity focused ultrasound beams. At the focus, HIFU induces a temperature elevation and the tissue can be thermally destroyed. In fact, this approach has been tested in a number of clinical studies for the treatment of several tumors, primarily the prostate, uterine, breast, bone, liver, kidney and pancreas. For transcranial brain therapy, the skull bone is a major limitation, however, new adaptive techniques of phase correction for focusing ultrasound through the skull have recently been implemented by research systems, paving the way for HIFU therapy to become an interesting alternative to brain surgery and radiotherapy.
authors.affiliation: Équipe de neuro-oncologie expérimentale, Inserm, UMRS 975, CNRS 7225, institut du cerveau et de la moelle épinière, groupe hospitalier La Pitié Salpêtrière-Charles-Foix, Assistance publique-Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75651 Paris, France. Electronic address: dervishielvis@hotmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Dervishi
authors.forename: J-F
authors.initials: JF
authors.lastname: Aubry
authors.forename: J-Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: A-L
authors.initials: AL
authors.lastname: Boch
mesh_terms: D001921:Brain / Q000601:surgery*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods; D006801:Humans; D019635:Neurosurgical Procedures; D012886:Skull / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods
keywords: Ablation thermique; Brain tumors; Chirurgie non invasive du cerveau; FUS; Focused Ultrasound Surgery (FUS); HIFU; High Intensity Focused Ultrasound (HIFU); MRIgFUS; Magnetic Resonance Imaging-guided focused ultrasound surgery (MRgFUS); Non-invasive brain surgery; Thermal ablation; Tumeurs cérébrales