title: [Epidemiology of hypertriglyceridemia].
abstract: It is controversial whether serum triglyceride levels are independent predictors or not. A large meta-analysis of 68 prospective studies reported that triglycerides showed a strong stepwise association with both cardiovascular diseases and ischemic stroke. However, after adjustment for high-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol, those associations were no longer significant. On the other hand, recent studies suggest that postprandial or non-fasting triglyceride levels may be better predictors of cardiovascular risk than fasting triglyceride levels. Triglyceride-rich lipoproteins plays a direct role in atherogenesis, and also promote compositional proatherogenic changes in low-density lipoprotein and high-density lipoprotein particles. These findings indicate the importance of measuring serum triglyceride levels in the postprandial period.
authors.affiliation: Public Health, Osaka University Graduate School of Medicne.
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides