title: An update on the use of antibodies against the filoviruses.
abstract: Multiple recent, independent studies have confirmed that passively administered antibodies can provide effective postexposure therapy in nonhuman primates after exposure to an otherwise lethal dose of Ebola virus or Marburg virus. In this article, we review composition and performance of the antibody cocktails tested thus far, what is known about antibody epitopes on the viral glycoprotein target and ongoing research questions in further development of such cocktails for pre-exposure or emergency postexposure use.
authors.affiliation: Department of Immunology & Microbial Science & The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. erica@scripps.edu.
authors.forename: Erica Ollmann
authors.initials: EO
authors.lastname: Saphire
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology / Q000627:therapeutic use*; D029043:Ebolavirus / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D000882:Haplorhini; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive; D008379:Marburg Virus Disease / Q000276:immunology / Q000628:therapy*; D029024:Marburgvirus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000939:Epitopes