title: Acute oxalate nephropathy associated with Clostridium difficile colitis.
abstract: We report the case of a 69-year-old man who presented with acute kidney injury in the setting of community-acquired Clostridium difficile-associated diarrhea and biopsy-proven acute oxalate nephropathy. We discuss potential mechanisms, including increased colonic permeability to oxalate. We conclude that C difficile-associated diarrhea is a potential cause of acute oxalate nephropathy.
authors.affiliation: Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA. Electronic address: acbucay@gmail.com.
authors.forename: Abraham
authors.initials: A
authors.lastname: Cohen-Bucay
authors.affiliation: Division of Nephrology, Tufts Medical Center, Boston, MA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Garimella
authors.affiliation: Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA.
authors.forename: Chukwudi
authors.initials: C
authors.lastname: Ezeokonkwo
authors.affiliation: Kidney Pathology Service, Department of Pathology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Bijol
authors.affiliation: Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA.
authors.forename: James A
authors.initials: JA
authors.lastname: Strom
authors.affiliation: Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA.
authors.forename: Bertrand L
authors.initials: BL
authors.lastname: Jaber
mesh_terms: D000208:Acute Disease; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001706:Biopsy; D002129:Calcium Oxalate / Q000378:metabolism*; D016360:Clostridioides difficile / Q000187:drug effects / Q000302:isolation & purification; D003106:Colon / Q000378:metabolism*; D003967:Diarrhea / Q000150:complications / Q000382:microbiology / Q000503:physiopathology; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D010539:Permeability; D019936:Probiotics / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D002129:Calcium Oxalate
keywords: Acute oxalate nephropathy; Clostridium difficile; acute diarrhea; acute kidney injury (AKI); acute renal failure; calcium oxalate; case report