title: Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2.
abstract: Despite the promise of targeting γδ T cells for cancer immunotherapy, the mechanisms underpinning the recruitment of this T-cell subsets to neoplastic lesions remain poorly understood. We have recently identified the pro-inflammatory chemokine CCL2 and its receptor CCR2 as key molecular determinants of γδ T-cell migration and tumor infiltration.
authors.affiliation: Instituto de Medicina Molecular; Faculdade de Medicina; Universidade de Lisboa; Lisboa, Portugal ; The Netherlands Cancer Institute; Amsterdam, The Netherlands.
authors.forename: Telma
authors.initials: T
authors.lastname: Lança
authors.forename: Bruno
authors.initials: B
authors.lastname: Silva-Santos
keywords: CCL2; CCR2; chemokines; tumor-infiltrating lymphocytes; γδ T cells