title: [Immunological evaluation of the supplementary immunization activities of measles-containing vaccine in Songjiang district of Shanghai in 2010].
abstract: OBJECTIVE
  To evaluate the immunological effectiveness of the supplementary immunization activities of measles-containing vaccine (MCV) in Songjiang district of Shanghai in 2010.
  
  
  METHODS
  60 children with 1 dose, 2 doses, or ≥3 doses of MCV respectively were selected randomly, and the blood samples were collected from these children to test the measles IgG antibodies both before and one month after the supplementary immunization(SI), using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The positive rate of measles antibody before SI was not significantly different from that one month after SI (P=0.250). However, both the positive rate of protection antibody (P<0.01) and the average concentration of antibody (P<0.01) one month after SI were higher than those before the SI. Preschool children had higher positive rate of protection antibody (P<0.01) than school children before SI, and their average concentration of antibody was higher than that of the school children both before (P<0.01) and after(P<0.01) SI. As for children with ≥ 3 doses of MCV, the positive rate of protection antibody (P<0.01) and the average concentration of antibody (P<0.01) were both significantly lower than those with 1 or 2 doses before SI but not afer SI(P>0.05). Comparing children who finished the measles immunization program to those who did not, the former had higher positive rate of protection antibody (P<0.01) before SI and higher average concentration of antibody both before and after (P<0.01) SI.
  
  
  CONCLUSIONS
  The supplementary immunization of MCV can improve the positive rate of protection antibody and the average concentration of the measles antibodies effectively.
authors.affiliation: Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Shen
authors.forename: Jiangping
authors.initials: J
authors.lastname: Reng
authors.forename: Wenhua
authors.initials: W
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Shikang
authors.initials: S
authors.lastname: Gu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000956:Antigens, Viral / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002681:China; D003625:Data Collection; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology*; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D000956:Antigens, Viral; D008458:Measles Vaccine