title: Highly ordered architecture of microRNA cluster.
abstract: Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology.
authors.affiliation: Department of Geriatric Cardiology, Beijing Military General Hospital, Beijing 100700, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Shi
authors.forename: Mingxuan
authors.initials: M
authors.lastname: Zhu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Mandun
authors.initials: M
authors.lastname: Zhang
mesh_terms: D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D005810:Multigene Family; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding; D059467:Transcriptome
chemical_list: C568997:MIR17HG, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding