title: Recent advances in immunotherapy for non-small-cell lung cancer.
abstract: Despite of recent development in the field of molecular targeted therapies, lung cancer is a leading cause of cancer death in the world. Remarkable progress has been made recently in immunotherapy for patients with non-small-cell lung cancer (NSCLC), with several modalities, concepts, and treatment settings being investigated. In vaccine development, large-scale clinical trials such as those with L-BLP25, belagenpumatucel-L, TG4010, and talactoferrin are already ongoing and some results have been reported. A trial of a vaccine as adjuvant therapy for patients with completely resected NSCLC is also ongoing with one of the major cancer-testis antigens, melanoma-associated antigen (MAGE)-A3. More recently, the effectiveness of multiple peptide vaccines has also been shown. Recently developed unique treatment modalities are the immune checkpoint inhibitors, such as antibodies against PD-1 and PD-L1, which also show promise. However, although therapeutic cancer vaccines are generally thought to be safe, severe adverse events should be monitored carefully when using immune checkpoint inhibitors. Here, we discuss recent advances and future perspectives of immunotherapy for patients with NSCLC.
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Owada
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Mitsuro
authors.initials: M
authors.lastname: Fukuharav
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamaura
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mutoh
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Okabe
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yaginuma
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yonechi
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ohsugi
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Hoshino
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shio
authors.affiliation: Department of Regenerative Surgery; Fukushima Medical University; School of Medicine; Fukushima, Japan.
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D019496:Cancer Vaccines / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends*; D016896:Treatment Outcome
chemical_list: D019496:Cancer Vaccines
keywords: adjuvant treatment; clinical trial; immune checkpoint inhibitor; multiple vaccine; non-small-cell lung cancer; therapeutic cancer vaccine