title: An efficient green multi-component reaction strategy for the synthesis of highly functionalised pyridines and evaluation of their antibacterial activities.
abstract: An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3,5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.
authors.affiliation: Department of Chemistry, Sri Venkateswara University.
authors.forename: Lakkireddy
authors.initials: L
authors.lastname: Srinivasula Reddy
authors.forename: Tirumalareddy
authors.initials: T
authors.lastname: Ram Reddy
authors.forename: Reddy Bodireddy
authors.initials: RB
authors.lastname: Mohan
authors.forename: Avula
authors.initials: A
authors.lastname: Mahesh
authors.forename: Yeramanchi
authors.initials: Y
authors.lastname: Lingappa
authors.forename: Nallagondu Chinna
authors.initials: NC
authors.lastname: Gangi Reddy
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002254:Carbonates / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D055772:Green Chemistry Technology; D008826:Microbial Sensitivity Tests; D011188:Potassium / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012997:Solvents / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002254:Carbonates; D011725:Pyridines; D012997:Solvents; C037593:potassium carbonate; C023666:pyridine; D011188:Potassium