title: Effect of desferoxamine on tissue and tumor retention of gallium-67: concise communication.
abstract: Desferoxamine (DEF) was administered intramuscularly (0.25 mg/g body weight) to mice harboring a Cloudman's melanoma S-91 3 hr before, simultaneously with, and 3 hr after i.v. injection of Ga-67 citrate (approximately 1 microCi/g body weight). Relative Ga-67 retention was compared with that in non-DEF controls at 24 hr. The chemical nature of Ga-67 excreted in urine following DEF was also studied in healthy mice. Desferoxamine administered 3 hr before Ga-67 had little effect on radiogallium localization; administration coincident with or 3 hr after radiogallium resulted in decreased retention at 24 hr. The effect was most profound when Ga-67 and DEF were administered simultaneously. In DEF-injected animals Ga-67 was excreted in the urine as a Ga-67-DEF complex. When DEF was administered 3 hr after Ga-67, there was a trend to greater tumor-to-blood activity ratios (.2 > p > .1).
authors.affiliation: Sec. of Nuclear Medicine, Dept. of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA.
authors.forename: P B
authors.initials: PB
authors.lastname: Hoffer
authors.forename: A
authors.initials: A
authors.lastname: Samuel
authors.forename: J T
authors.initials: JT
authors.lastname: Bushberg
authors.forename: M
authors.initials: M
authors.lastname: Thakur
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D003676:Deferoxamine / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000378:metabolism; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D002614:Chelating Agents; D005710:Gallium Radioisotopes; D003676:Deferoxamine