title: Attenuation of gentamycin-induced nephrotoxicity in rats by dietary inclusion of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes.
abstract: This study sought to investigate the modulatory effects of dietary inclusion of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes on antioxidant status and renal damage induced by gentamycin in rats. Renal damage was induced in albino rats pretreated with dietary inclusion of ginger and turmeric (2% and 4%) by intraperitoneal (i.p.) administration of gentamycin (100 mg/kg body weight) for three days. Assays for renal damage biomarkers (plasma creatinine, plasma urea, blood urea nitrogen and plasma uric acid), malondialdehyde (MDA) content and reduced glutathione (GSH) content as well as renal antioxidant enzymes (catalase, glutathione-S-transferase (GST), glutathione peroxidase (GPx) and superoxide dismutase (SOD)) were carried out. The study revealed significant (p < 0.05) increases in renal damage biomarkers following gentamycin administration with severe alteration in kidney antioxidant status. However, pretreatment with ginger and turmeric rhizome (2% and 4%) prior to gentamycin administration significantly (p < 0.05) protected the kidney and attenuated oxidative stress by modulating renal damage and antioxidant indices. This finding therefore suggests that dietary inclusion of ginger and turmeric rhizomes may protect against gentamycin-induced nephrotoxicity and oxidative stress.
authors.affiliation: 1Functional Foods and Nutraceuticals Unit, Federal University of Technology, Akure, Nigeria.
authors.forename: Adedayo O
authors.initials: AO
authors.lastname: Ademiluyi
authors.forename: Ganiyu
authors.initials: G
authors.lastname: Oboh
authors.forename: Opeyemi B
authors.initials: OB
authors.lastname: Ogunsuyi
authors.forename: Ayodele J
authors.initials: AJ
authors.lastname: Akinyemi
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D000975:Antioxidants / Q000378:metabolism; D001806:Blood Urea Nitrogen; D030024:Curcuma / Q000378:metabolism*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000633:toxicity*; D020939:Zingiber officinale / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009549:Nigeria; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005839:Gentamicins; D010936:Plant Extracts
keywords: Curcuma longa; Ginger; Zingiber officinale; gentamycin; nephrotoxicity; oxidative stress; turmeric