title: BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition.
authors.affiliation: Joint Ludwig-Austin Oncology Unit, Austin Health, Victoria, Australia.
authors.forename: Miles C
authors.initials: MC
authors.lastname: Andrews
authors.forename: Andreas
authors.initials: A
authors.lastname: Behren
authors.forename: Fiona
authors.initials: F
authors.lastname: Chionh
authors.forename: John
authors.initials: J
authors.lastname: Mariadason
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Vella
authors.forename: Hongdo
authors.initials: H
authors.lastname: Do
authors.forename: Alexander
authors.initials: A
authors.lastname: Dobrovic
authors.forename: Niall
authors.initials: N
authors.lastname: Tebbutt
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cebon
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D048369:MAP Kinase Kinase 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D048370:MAP Kinase Kinase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010091:Oximes / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras); D011728:Pyridones / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D016896:Treatment Outcome; D018631:ras Proteins / Q000235:genetics*
chemical_list: D007093:Imidazoles; C117307:KRAS protein, human; D010091:Oximes; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011728:Pyridones; D011744:Pyrimidinones; C560077:trametinib; D048493:Proto-Oncogene Proteins B-raf; D048369:MAP Kinase Kinase 1; D048370:MAP Kinase Kinase 2; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; C561627:dabrafenib