title: N-containing Ag(I) and Hg(II) complexes: a new class of antibiotics.
abstract: Several classes of antimicrobial compounds are presently available; microorganism's resistance to these drugs constantly emerges. In order to prevent this serious medical problem, the elaboration of new types of antibacterial agents or the expansion of bioactivity of the naturally known biosensitive compounds is a very interesting research problem. The synthesis and characterization of metal complexes with organic bioactive ligands is one of the promising fields for the search. The biological activities of the metal complexes differ from those of either the ligand or the metal ion. The results obtained thus far have led to the conclusion that structural factors, which govern antimicrobial activities, are strongly dependent on the central metal ion. A review of papers dealing with the Ag(I) and Hg(II) complexes of N donor ligands is presented. These metal complexes of N-chelating ligands have attracted considerable attention because of their interesting physicochemical properties and pronounced biological activities. This review will mainly focus on the preparation procedures and antibacterial properties of free organic ligands and the corresponding complexes. Finally, a research about antimicrobial properties of new Hg(II) complexes with 5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione (L) and various halogen ions, HgL2X2 (X = Cl¯ (49), Br¯ (50), and I¯ (51)), is reported. Noteworthy antimicrobial activities, evaluated by minimum inhibitory concentration, for these complexes were observed.
authors.forename: Seyyed Javad
authors.initials: SJ
authors.lastname: Sabounchei
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan 65174, Iran. jsabounchei@yahoo.co.uk.
authors.forename: Parisa
authors.initials: P
authors.lastname: Shahriary
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002614:Chelating Agents / Q000138:chemical synthesis; D056831:Coordination Complexes; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009941:Organomercury Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D056831:Coordination Complexes; D008024:Ligands; D009941:Organomercury Compounds; D009942:Organometallic Compounds; D012834:Silver