title: [High flow, humidified-reheated oxygen therapy: a new oxygenation technique for adults].
abstract: Currently conventional oxygen therapy is the first choice symptomatic treatment in the management of acute respiratory failure (ARF). However, conventional oxygen therapy has important limitations which have lead to the development of heated and humidified high-flow nasal oxygen therapy (HFNO). HFNO is an innovative technique that can deliver, through special nasal cannulae, up to 100% of the inspired fraction (FiO2) with heated and humidified oxygen at a maximum flow of 70L/min. The characteristics of this technique (overcoming the patient's spontaneous inspiratory flow, heated humidification,) and its physiological effects (no dilution of FiO2, positive end-expiratory pressure, pharyngeal dead-space washout, decrease in airway resistance), allow efficient optimization of oxygenation with better tolerance for patients. Current data, mainly observational, show that HFNO could be used particularly for the management of hypoxemic ARF, notably in the more severe forms. Indications for using HFNO, alone or in association with noninvasive ventilation, are potentially very broad and may involve different types of ARF (post-operative, post-extubation, palliative care) and even the practice of invasive technical procedures (bronchial fibroscopy). However, though current studies are very encouraging and promise a clinical benefit on patient outcomes, randomized trials are still needed to demonstrate that HFNO avoids the need for endotracheal intubation in the management of ARF.
authors.affiliation: Service de réanimation médicale, CHRU Jean-Bernard, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France. Electronic address: jean-pierre.frat@chu-poitiers.fr.
authors.forename: J-P
authors.initials: JP
authors.lastname: Frat
authors.forename: V
authors.initials: V
authors.lastname: Goudet
authors.forename: C
authors.initials: C
authors.lastname: Girault
mesh_terms: D000328:Adult; D006358:Hot Temperature; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods; D012119:Respiration; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*; D014867:Water
chemical_list: D014867:Water
keywords: Acute respiratory failure; Heated and humidified high-flow nasal oxygen therapy; Insuffisance respiratoire aiguë; Noninvasive ventilation; Oxygénothérapie à haut débit; Ventilation non invasive