title: Preliminary study of effects of multiple oral dosing of clarithromycin on the pharmacokinetics of cyclosporine in dogs.
abstract: Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of CLM may decrease the required CsA dosage in CsA-based immunosuppressive therapy in renal transplanted dogs.
authors.affiliation: Division of Small Animal Surgery, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Katayama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Rieko
authors.initials: R
authors.lastname: Katayama
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Shimamura
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uzuka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D017291:Clarithromycin / Q000008:administration & dosage / Q000494:pharmacology*; D016572:Cyclosporine / Q000378:metabolism / Q000493:pharmacokinetics*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007165:Immunosuppression Therapy / Q000379:methods / Q000662:veterinary
chemical_list: D016572:Cyclosporine; D017291:Clarithromycin