title: Association of glutathione S-transferase P1 (GSTP1) polymorphism with Tourette syndrome in Taiwanese patients.
abstract: The etiology of Tourette syndrome (TS) is multifactorial. TS vulnerability may be associated with genetic and environmental factors. From the genetic point of view, TS is heterogeneous. Previous studies showed that some single-nucleotide polymorphisms (SNPs) of the glutathione-S-transferase P1 (GSTP1) gene can affect cellular proliferation and apoptotic activity and TS is a neurodevelopmental disorder. We guessed that there was a relationship between TS and genetic variants of the GSTP1 gene. Therefore, in this study, we aimed to test the hypothesis that GSTP1 SNPs were associated with TS. We performed a case-control study. One hundred twenty-one TS children and 105 normal children were included in the study. Polymerase chain reaction was used to identify the GSTP1 gene polymorphism at position rs6591256 (A/G, promoter polymorphism) in TS patients and normal children. The polymorphism at position rs6591256 in the GSTP1 gene revealed significant differences in the allele (p=0.0135) and genotype (p=0.0159) distributions between the TS patients and the control group. The A allele was present at a higher frequency than the G allele in the TS patients compared with the control group (odds ratio [OR]=1.91, 95% confidence interval [CI]: 1.14-3.21). The AA genotype was associated with susceptibility to TS with an OR of 2.38 for the AA versus AG genotype (95% CI: 1.29-4.41). These findings suggest that variants in the GSTP1 gene may play a role in susceptibility to TS.
authors.affiliation: 1 Institute of Bioinformatics and Structural Biology, National Tsing Hua University , Hsinchu, Taiwan .
authors.forename: Che-Piao
authors.initials: CP
authors.lastname: Shen
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Chou
authors.forename: Hsin-Ping
authors.initials: HP
authors.lastname: Liu
authors.forename: Cheng-Chun
authors.initials: CC
authors.lastname: Lee
authors.forename: Yuhsin
authors.initials: Y
authors.lastname: Tsai
authors.forename: Bor-Tsang
authors.initials: BT
authors.lastname: Wu
authors.forename: Ban-Dar
authors.initials: BD
authors.lastname: Hsu
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Lin
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D017931:DNA Primers; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013624:Taiwan; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: D017931:DNA Primers; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi