title: [The effectiveness of romifidine on myocardial function in horses with and without heart disease, evaluated with M-mode echocardiography and PW-tissue Doppler imaging].
abstract: The aim of this study was to evaluate to what extent the myocardial function in horses (measured by PW-tissue Doppler = PW-TDI) is affected during a sedation with romifidine (0.04 mg/kg, i. v.), particularly in case of an accompanying heart disease. Based on an echo- and electrocardiographic examination, a total of 45 horses was subdivided into group 1 (no heart disease), group 2 (heart disease without increased heart dimensions) and group 3 (heart disease with increased heart dimensions). Heart rate (HF), M-mode- (FS%) and TDI-measurements were performed before and after the application of romifidine. The velocities of the radial myocardial movement in the left and right ventricular wall were evaluated using PW-TDI. The TDI parameters included the isovolumic contraction (IVC), the systolic (S) as well as the early (E) and late diastolic maximal velocity (A). After the application of romifidine HF and FS were significantly decreased in all groups. IVC, S and E, determined by PW-TDI were also significantly decreased in both ventricular walls. A significant difference between groups was shown for the isovolumic contraction in the left ventricular wall. This was observed distinctly more in horses with heart disease and increased heart dimensions compared to horses with heart disease but no increased heart dimensions. The results of the study indicate that PW-TDI is a suitable imaging technique to analyse the effects of romifidine on equine myocardial function. The major percentage change after application of romifidine for TDI measurements compared to the M-mode parameters indicate that the parameter myocardial velocity measured with TDI appeared to be the most sensitive parameter to document romifidine--induced changes on the myocardium.
authors.affiliation: Klinik für Pferde, Zentrum für klinische Tiermedizin, Tierärztliche Fakultät der Ludwig-Maximilians-Universität München.
authors.forename: Deborah
authors.initials: D
authors.lastname: Nagel
authors.forename: Heidrun
authors.initials: H
authors.lastname: Gehlen
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D004452:Echocardiography / Q000662:veterinary; D018619:Echocardiography, Doppler, Pulsed / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006734:Horse Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006736:Horses / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000777:Anesthetics; D007093:Imidazoles; C076257:romifidine