title: Zipper interacting protein kinase (ZIPK): function and signaling.
abstract: Zipper interacting protein kinase (ZIPK), also known as death associated protein kinase 3, is a serine/threonine kinase that mediates variety of cell functions. The major biologic function of ZIPK is considered to be the regulation of apoptosis and smooth muscle contraction. Recently, several other functions of ZIPK have been gradually clarified. In this review article, we summarized the recent findings on ZIPK function and ZIPK-related cell signaling. We propose that ZIPK is a potential future target for the development of pharmaceutical therapy for cancer as well as cardiovascular diseases.
authors.affiliation: Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada, Aomori, 034-8628, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Usui
authors.forename: Muneyoshi
authors.initials: M
authors.lastname: Okada
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yamawaki
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology; D016923:Cell Death; D002465:Cell Movement; D049109:Cell Proliferation; D064550:Death-Associated Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D016350:Leucine Zippers; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D064550:Death-Associated Protein Kinases