title: Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study.
abstract: Curcumin has various biological activities including antioxidant and antiinflammatory actions, and alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to realize its bioactivities. We have generated capsules and tablets containing Theracurmin, a highly absorptive curcumin. In addition, we recently created a drinkable preparation of Theracurmin. To evaluate the absorption efficiency of this type of curcumin, we performed a single-dose, double-blind, 4-way crossover study. We compared plasma curcumin levels after the administration of Theracurmin beverage and 3 other drinkable types of curcumin sold in Japan. Twenty-four healthy subjects (male/female=13/11, age: 23-32) were administered with these 4 drinkable preparations of curcumin. The area under the blood concentration-time curve at 0-8 h was found to be 1.5 to 4.0-fold higher with Theracurmin than with the other 3 kinds of curcumin beverage. Moreover, maximal plasma curcumin concentrations (0-8 h) of Theracurmin were 1.8 to 3.8 times higher than those of the other 3 curcumin beverages. These data indicate that our newly prepared Theracurmin beverage exhibits a much better absorption efficiency than other kinds of curcumin beverage sold in Japan.
authors.affiliation: Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morimoto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sunagawa
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Katanasaka
authors.forename: Sae
authors.initials: S
authors.lastname: Hirano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Namiki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Doi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Yokoji
authors.forename: Eriko
authors.initials: E
authors.lastname: Miyoshi-Morimoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hamada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imaizumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nonaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Fuwa
authors.forename: Takanori
authors.initials: T
authors.lastname: Teramoto
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakeya
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wada
authors.forename: Koji
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D000975:Antioxidants / Q000493:pharmacokinetics; D001628:Beverages; D018592:Cross-Over Studies; D003474:Curcumin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003474:Curcumin