title: Heart-type fatty acid-binding protein may exclude acute myocardial infarction on admission to emergency department for chest pain.
abstract: Chest pain is one of the most frequent reasons for presentation to the emergency department (ED), although the estimated prevalence of AMI (acute myocardial infarction) in the ED is about 4%. One criterion for diagnosis of AMI is the demonstration of a rise and/or fall in cardiac troponins, but time is needed for this to happen. Thus, the use of an additional 'early marker' of cardiac injury may aid to exclude AMI rapidly. The aim of the study was to evaluate the possibility of excluding AMI with the determination of heart-type fatty acid-binding protein (H-FABP) on baseline samples of patients referring to the ED for chest pain. 26 AMI patients and 41 non-AMI comparisons were included in the study. Both H-FABP and high sensitivity cardiac troponin T (hs-cTnT) were measured in baseline samples from these subjects. H-FABP had a negative predictive value of 100%, thus indicating the possibility of its usage in a rule-out strategy for AMI in ED for patients presenting with chest pain.
authors.affiliation: Department of Laboratory Medicine, University Milano-Bicocca, Desio Hospital , Desio (MB) , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cappellini
authors.forename: Simona
authors.initials: S
authors.lastname: Da Molin
authors.forename: Stefano
authors.initials: S
authors.lastname: Signorini
authors.forename: Fausto
authors.initials: F
authors.lastname: Avanzini
authors.forename: Donata
authors.initials: D
authors.lastname: Saltafossi
authors.forename: Rosanna
authors.initials: R
authors.lastname: Falbo
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D010343:Patient Admission; D012372:ROC Curve; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins