title: Hemodynamic numerical simulation and analysis of oscillatory blood flow in growing aneurysms.
abstract: Hemodynamics plays a crucial role in the formation, progression and rupture of intracranial aneurysms. Understanding these mechanisms is important to improve current diagnosis and treatment of intracranial aneurysms. In this study we simulate and analyze the pressure gradients and the blood flow fields in growing intracranial aneurysms. Firstly, the pressure gradients are obtained according to the blood velocity waveform at the axis of the inlet to the artery, which can be acquired by transcranial Doppler technology. Then, blood flow fields are calculated by solving the linearized Navier-Stokes equations and continuity equation using the Fourier series method. Results show that the higher the aneurysm dilatation degree is, the lower the maximum oscillatory velocity will be. Therefore, the oscillatory velocity may be used to analyze the characteristics of blood flow signals from aneurysm and to forecast the size of aneurysm. This sensitive parameter can be utilized for the detection of vessel diseases, which is promising to provide a useful reference in clinical application.
authors.affiliation: Department of Automatic Control and mechanical engineering, Kunming University, Kunming, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhou
authors.forename: Mingxiu
authors.initials: M
authors.lastname: Shen
authors.forename: Yanping
authors.initials: Y
authors.lastname: Sun
authors.forename: Guifang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D004106:Dilatation; D005583:Fourier Analysis; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology*; D008955:Models, Cardiovascular; D009991:Oscillometry; D011312:Pressure; D011673:Pulsatile Flow / Q000502:physiology; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D018608:Ultrasonography, Doppler
keywords: aneurysms; hemodynamics; numerical simulation; oscillatory blood flow; pressure gradients