title: The frustrated gene: origins of eukaryotic gene expression.
abstract: Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: hitenmadhani@gmail.com.
authors.forename: Hiten D
authors.initials: HD
authors.lastname: Madhani
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D004251:DNA Transposable Elements; D005057:Eukaryotic Cells / Q000737:chemistry / Q000502:physiology* / Q000821:virology*; D015870:Gene Expression; D056084:Genetic Fitness; D012326:RNA Splicing; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014780:Viruses / Q000235:genetics*
chemical_list: D002843:Chromatin; D004251:DNA Transposable Elements; D012333:RNA, Messenger