title: Hyperuricemia in patients with chronic plaque psoriasis.
abstract: BACKGROUND
  Few studies have examined the association between elevated serum uric acid (SUA) levels and psoriasis, and their results have been inconclusive because most of these studies did not take into account the confounding effects of coexisting features of the metabolic syndrome.
  
  
  OBJECTIVE
  We compared the prevalence of hyperuricemia and SUA levels between psoriatic patients and control individuals.
  
  
  METHODS
  Levels of SUA were measured in 119 consecutive psoriatic patients and 119 control individuals matched for age, sex, and body mass index.
  
  
  RESULTS
  Compared with control subjects, psoriatic patients had higher SUA levels (5.61 ± 1.6 vs 4.87 ± 1.4 mg/dL; P < .001) and a remarkably greater prevalence of asymptomatic hyperuricemia (19% vs 7%; P < .001). Multivariate logistic regression analysis revealed that psoriasis was the strongest predictor of hyperuricemia (odds ratio 3.20; 95% confidence interval 1.32-7.58; P < .01) after adjusting for age, sex, and metabolic syndrome features.
  
  
  CONCLUSIONS
  The cross-sectional design of this study does not allow us to draw any conclusion about a causal relation between psoriasis and hyperuricemia.
  
  
  CONCLUSIONS
  Hyperuricemia is a common finding in psoriatic patients. Its treatment might be clinically useful for the global treatment of patients.
authors.affiliation: Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy. Electronic address: paolo.gisondi@univr.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gisondi
authors.affiliation: Section of Endocrinology, Diabetes, and Metabolism, University of Verona, Verona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
authors.affiliation: Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Cagalli
authors.affiliation: Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D011565:Psoriasis / Q000097:blood / Q000453:epidemiology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: BMI; CVD; PASI; PsA; Psoriasis Area and Severity Index; SUA; body mass index; cardiovascular disease; cardiovascular risk; hyperuricemia; psoriasis; psoriatic arthritis; serum uric acid; uric acid