title: The die is cast: arsenic exposure in early life and disease susceptibility.
abstract: Early life exposure to arsenic in humans and mice produces similar patterns of disease in later life. Given the long interval between exposure and effect, epigenetic effects of early life exposure to arsenic may account for the development and progression of disease in both species. Mode of action and dosimetric studies in the mouse may help assess the role of age at exposure as a factor in susceptibility to the toxic and carcinogenic effects of arsenic in humans.
authors.affiliation: Pharmacokinetics Branch, Integrated Systems Toxicology Division, National Health and Environmental Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27709, United States.
authors.forename: David J
authors.initials: DJ
authors.lastname: Thomas
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D004198:Disease Susceptibility / Q000139:chemically induced* / Q000453:epidemiology; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000235:genetics; D005260:Female; D006801:Humans; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics
chemical_list: D001151:Arsenic