title: The effects of vector movement and distribution in a mathematical model of dengue transmission.
abstract: BACKGROUND
  Mathematical models have been used to study the dynamics of infectious disease outbreaks and predict the effectiveness of potential mass vaccination campaigns. However, models depend on simplifying assumptions to be tractable, and the consequences of making such assumptions need to be studied. Two assumptions usually incorporated by mathematical models of vector-borne disease transmission is homogeneous mixing among the hosts and vectors and homogeneous distribution of the vectors.
  
  
  RESULTS
  We explored the effects of mosquito movement and distribution in an individual-based model of dengue transmission in which humans and mosquitoes are explicitly represented in a spatial environment. We found that the limited flight range of the vector in the model greatly reduced its ability to transmit dengue among humans. A model that does not assume a limited flight range could yield similar attack rates when transmissibility of dengue was reduced by 39%. A model in which mosquitoes are distributed uniformly across locations behaves similarly to one in which the number of mosquitoes per location is drawn from an exponential distribution with a slightly higher mean number of mosquitoes per location. When the models with different assumptions were calibrated to have similar human infection attack rates, mass vaccination had nearly identical effects.
  
  
  CONCLUSIONS
  Small changes in assumptions in a mathematical model of dengue transmission can greatly change its behavior, but estimates of the effectiveness of mass dengue vaccination are robust to some simplifying assumptions typically made in mathematical models of vector-borne disease.
authors.affiliation: Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Chao
authors.forename: Ira M
authors.initials: IM
authors.lastname: Longini
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Halloran
mesh_terms: D000818:Animals; D009033:Culicidae / Q000821:virology; D003715:Dengue / Q000453:epidemiology / Q000635:transmission*; D003716:Dengue Virus / Q000276:immunology; D006801:Humans; D015994:Incidence; D007303:Insect Vectors / Q000821:virology; D032541:Mass Vaccination; D008962:Models, Theoretical; D011156:Population Density; D011157:Population Dynamics; D013785:Thailand