title: Mono- and bis-furanone derivatives from the endolichenic fungus Peziza sp.
abstract: Seven new mono- and bis-furanones, pezizolides A-G (1-7), have been isolated from the crude extract of the endolichenic fungus Peziza sp. inhabiting the lichen Xanthoparmelia sp. The structures of the new compounds were elucidated mainly by NMR and MS methods. The absolute configuration of 1-4 was assigned by the application of CD exciton chirality method, and 1 was further supported by electronic circular dichroism (ECD) calculations, whereas that of 5 was deduced by Snatzke's method following the relative configuration analysis of its acetonide. The cytotoxity and antimicrobial activity of compounds 1-7 were tested.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China; Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Ren
authors.affiliation: Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Ge
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.affiliation: Shanghai Normal University, Shanghai 200234, PR China. Electronic address: chendj@sipi.com.cn.
authors.forename: Daijie
authors.initials: D
authors.lastname: Chen
authors.affiliation: Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China. Electronic address: Cheys@im.ac.cn.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D001688:Biological Products; D005663:Furans
keywords: Electronic circular dichroism; Endolichenic fungus; Furanones; Peziza sp.