title: Novel cellulose based materials for safe and efficient wound treatment.
abstract: The present study aims at achieving effects of improved hydrophilicity and microorganism inhibition, which are rarely simultaneously present in wound dressings. Viscose fibers in their non-woven form were modified using two different pathways. Effects of a two-step procedure, i.e. alkaline or oxygen plasma treatment followed by the attachment of silver chloride nanoparticles were compared to a one-step procedure, i.e. ammonium plasma treatment, which results in both desired material characteristics simultaneously. The surface properties of untreated and differently modified cellulose samples were analyzed by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), in vitro silver release, and hydrophilicity measurements. The treatment effect on antimicrobial activity was determined by the AATCC 100-1999 standard test. In light of the introduced wound dressing preparation procedures and the desired wound dressing characteristics, the effectiveness of the used procedures was evaluated. Antimicrobial activity was proven against all Gram negative bacteria, while the Gram positive bacteria survive the as-prepared samples. Hydrophilicity was proven to be excellent using both preparation procedures. The mentioned results prove the potential of the used procedures and encourage future developments toward the clinical proof of concept.
authors.affiliation: Center of Excellence Polymer Materials and Technologies, Slovenia; Faculty of Mechanical Engineering, University of Maribor, Slovenia.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Peršin
authors.forename: Uroš
authors.initials: U
authors.lastname: Maver
authors.forename: Tanja
authors.initials: T
authors.lastname: Pivec
authors.forename: Tina
authors.initials: T
authors.lastname: Maver
authors.forename: Alenka
authors.initials: A
authors.lastname: Vesel
authors.forename: Miran
authors.initials: M
authors.lastname: Mozetič
authors.forename: Karin
authors.initials: K
authors.lastname: Stana-Kleinschek
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001458:Bandages / Q000382:microbiology*; D002482:Cellulose / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D012449:Safety; D012834:Silver / Q000737:chemistry; D013499:Surface Properties; D014947:Wounds and Injuries / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D002482:Cellulose
keywords: Antimicrobial activity; Hydrophilicity; Plasma treatment; Wound dressing materials