title: Spectroscopic analysis, DNA binding and antimicrobial activities of metal complexes with phendione and its derivative.
abstract: A novel ligand (E)-2-styryl-1H-imidazo [4, 5-f] [1, 10] phenanthroline(L) has been synthesized from 1,10-phenanthroline-5,6-dione. Its transition metal complexes, [FeLCl4][L-H] and [CuL2](NO3)2 have also been synthesized. Besides, three mixed ligand lanthanide metal complexes of Phendione and β-diketones have been synthesized, namely [Eu(TFN)3(Phendione)] (TFN = 4,4,4-trifluoro-1(2-napthyl)-1,3-butanedione), [Eu(HFT)3(Phendione)] (HFT = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)-1,3-hexanedione), [Yb(HFA)3(Phendione)] (hfa = hexafluoroacetylacetonate). The synthesized ligands and metal complexes have been characterized by FTIR, UV-Visible spectroscopy and PL spectra. DNA binding activities of the complexes and the ligands have been studied by DNA gel electrophoresis. DNA binding studies showed that Fe complex of the synthesized ligand is more potent DNA binding and damaging agent compare to others under study. The synthesized compounds were also screened for their antimicrobial activities by disc diffusion method against three microbes, namely Escherichia coli, Staphylococcus aureus, Proteus penneri. The lanthanide complexes of phendione showed great antibacterial activities.
authors.affiliation: Department of Chemistry, Shah Jalal University of Science and Technology, Sylhet, Bangladesh. Electronic address: subhan-che@sust.edu.
authors.forename: Md Abdus
authors.initials: MA
authors.lastname: Subhan
authors.forename: Md
authors.initials: M
authors.lastname: Saifur Rahman
authors.forename: Khyrul
authors.initials: K
authors.lastname: Alam
authors.forename: Md
authors.initials: M
authors.lastname: Mahmud Hasan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D049449:Luminescence; D008826:Microbial Sensitivity Tests; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D010618:Phenanthrolines; D028561:Transition Elements; D004247:DNA
keywords: Anti-bacteria; DNA gel electrophoresis; Lanthanide; Luminescence; Phendione