title: Transient leopard spot corneal endothelial staining with trypan blue during cataract surgery in a child with congenital rubella syndrome.
abstract: We report the complication of corneal endothelial staining with trypan blue that limited the surgical view during cataract extraction in a 10-month-old boy. The boy had presented with a pigmentary retinopathy, microphthalmia, and a dense, white, unilateral congenital cataract. He was suspected of having, and was later diagnosed with, congenital rubella syndrome. We hypothesize that the corneal staining may have resulted from virally induced corneal endothelial damage. To our knowledge, this is the first reported case of trypan blue adversely affecting congenital cataract surgery.
authors.affiliation: School of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
authors.forename: Andrew
authors.initials: A
authors.lastname: Baldwin
authors.forename: Justin
authors.initials: J
authors.lastname: Risma
authors.forename: Susannah
authors.initials: S
authors.lastname: Longmuir
mesh_terms: D002387:Cataract Extraction; D004396:Coloring Agents / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D004728:Endothelium, Corneal / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications; D008297:Male; D012410:Rubella Syndrome, Congenital / Q000601:surgery; D014343:Trypan Blue / Q000009:adverse effects*
chemical_list: D004396:Coloring Agents; D014343:Trypan Blue