title: Successful management of invasive pulmonary nocardiosis and aspergillosis in a patient with T-cell lymphoma: a case report.
abstract: In patients with malignant hematological disorders receiving immunosuppressive therapy, invasive pulmonary infections are serious complications that are associated with high morbidity and mortality. In immunocompromised hosts with impaired cellular immunity, two or more organisms may coexist leading to a wide range of clinical and radiological manifestations. Reported here is an old man who was diagnosed to have angioimmunoblastic T-cell lymphoma at King Faisal Specialist Hospital and Research Centre in Riyadh in December 2004. The lymphoma was treated with various immunosuppressive agents including alemtuzumab. In October 2006, the patient was admitted with severe bronchopneumonia caused by Nocardia asteroides and Aspergillus niger that was complicated by septic shock. The invasive pulmonary infections were successfully treated with trimethoprim-sulphamethoxazole, amikacin and liposomal amphotericin-B (amBisome).
authors.affiliation: Section of Adult Hematology and Hematopoietic Stem Cell Transplant, King Faisal Cancer Centre, King Faisal Specialist Hospital and Research Centre, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
authors.forename: Khalid A
authors.initials: KA
authors.lastname: Al-Anazi
authors.forename: Mahmoud D
authors.initials: MD
authors.lastname: Aljurf
authors.forename: Fahad I
authors.initials: FI
authors.lastname: Al-Mohareb
authors.forename: Laila
authors.initials: L
authors.lastname: Al-Dabal
authors.forename: Mohammed
authors.initials: M
authors.lastname: Zaitoni
authors.forename: Majed
authors.initials: M
authors.lastname: Halim
keywords: Aspergillus niger; Nocardia asteroides; angioimmunoblastic T-cell lymphoma; invasive pulmonary infections