title: Long noncoding RNAs: Novel insights into hepatocelluar carcinoma.
abstract: Recent advances in non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack of coding protein function, termed long noncoding RNAs (lncRNAs). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNAs world. Moreover, accumulating studies have demonstrated that a class of lncRNAs are dysregulated in hepatocellular carcinoma(HCC) and closely related with tumorigenesis, metastasis, prognosis or diagnosis. In this review, we will briefly discuss the regulation and functional role of lncRNAs in HCC, therefore evaluating the potential of lncRNAs as prospective novel therapeutic targets in HCC.
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Meng
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Bao-Ming
authors.initials: BM
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.
authors.forename: Xiong-Wen
authors.initials: XW
authors.lastname: Lv
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China. Electronic address: heyongR99@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: CCKBR; CDH1; CLDN1; CREB; DDIT4; DNA damage-inducible transcript 4; E-cadherin; EZH2; Function; Gtl2; HBx; HCC; HOTAIR; HOXC; HSC; Hepatocellular carcinoma (HCC); IGF2; IGF2 mRNA-binding proteins; IGF2BP; KRT-19; KRT-8; Long noncoding RNAs; MALAT1; MAML1; MEF2C; MEG3; MVIH; P21 associated ncRNA DNA damage activated; PANDA; PGK1; PIWI-interacting RNAs; PRC2; RAB4B; Ras-related GTP-binding protein 4B; SNPs; TERRA; TERT; TSA; Therapeutic targets; Trichostatin A; cAMP responsive element binding protein; cholecystokinin-B receptor; claudin 1; cytokeratin-19; cytokeratin-8; down-regulated expression by hepatitis B virus X protein (HBx); gene trap locus 2; hepatic stellate cells; hepatitis B virus X protein; hepatocellular carcinoma; heterogeneous nuclear ribonucleoprotein K; hnRNP-K; homeobox transcription factors C; hox transcript antisense intergenic RNA; insulin-like growth factor 2; lncRNA High Expression In HCC; lncRNA Low Expression in Tumor; lncRNA-Dreh; lncRNA-HEIH; lncRNA-LET; lncRNAs; lncRNAs associated with microvascular invasion in HCC; long noncoding RNAs; mastermind-like-1; maternally expressed gene 3; metastasis-associated lung adenocarcinoma transcript 1; miRNAs; microRNAs; myocyte-specific enhancer factor 2C; ncRNAs; non-coding RNAs; phospho-glycerate kinase 1; piRNAs; polycomb-repressive complex 2; siRNAs; single nucleotide polymorphisms; small interfering RNAs; telomerase reverse transcriptase; telomeric repeat-containing RNA; zeste homolog 2