title: Health-related quality of life of bone marrow versus peripheral blood stem cell donors: a prespecified subgroup analysis from a phase III RCT-BMTCTN protocol 0201.
abstract: Hematopoietic stem cells can be procured from unrelated donors via either the bone marrow (BM) aspiration or peripheral blood stem cell (PBSC) collection methods. There is no evidence from prospective randomized trials in the unrelated donor setting about the relative health-related quality-of-life (HRQoL) benefits/costs to donors. The goals of this prospective longitudinal investigation were to describe and compare the donation-related HRQoL experiences of 332 BM and PBSC donors. Donors were interviewed before donation, 48 hours after donation, weekly until fully recovered, and at 6 and 12 months after donation. Before donation, BM donors had lower confusion, fewer concerns, and were more prepared for donation. Shortly after donation, BM donors reported more physical side effects. BM donors also reported more donation-related impact on their social activities. However, BM donors reported somewhat better psychological status and were more likely to indicate that the donation made their lives more meaningful. There were virtually no longer term differences in the experiences of the 2 donor groups, including no recovery time difference beginning 3 weeks after donation. Although BM donors may experience the process as more physically stressful and more psychologically beneficial in the short term, the longer term HRQoL consequences of BM and PBSC donors are similar.
authors.affiliation: Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: SwitzerGE@upmc.edu.
authors.forename: Galen E
authors.initials: GE
authors.lastname: Switzer
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Jessica G
authors.initials: JG
authors.lastname: Bruce
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Donna
authors.initials: D
authors.lastname: Harrington
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota; National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Michael
authors.initials: M
authors.lastname: Haagenson
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Drexler
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
authors.forename: Amy
authors.initials: A
authors.lastname: Foley
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
authors.forename: Dennis
authors.initials: D
authors.lastname: Confer
authors.affiliation: University of Florida, College of Medicine, Gainesville, Florida.
authors.forename: Michelle
authors.initials: M
authors.lastname: Bishop
authors.affiliation: MD Anderson Cancer Center, University of Texas, Houston, Texas.
authors.forename: Paolo
authors.initials: P
authors.lastname: Anderlini
authors.affiliation: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors.forename: Scott
authors.initials: S
authors.lastname: Rowley
authors.affiliation: NIH Clinical Center, National Institutes of Health, Bethesda, Maryland.
authors.forename: Susan F
authors.initials: SF
authors.lastname: Leitman
authors.affiliation: Moffitt Cancer Center, Tampa, Florida.
authors.forename: Claudio
authors.initials: C
authors.lastname: Anasetti
authors.affiliation: University of Florida, College of Medicine, Gainesville, Florida.
authors.forename: John R
authors.initials: JR
authors.lastname: Wingard
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000502:physiology; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D019520:Living Donors / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012923:Social Class; D020858:Tissue and Organ Harvesting; D061349:Unrelated Donors / Q000523:psychology*
keywords: Marrow versus peripheral blood stem cell donation; Randomized trial; Unrelated hematopoietic stem cell donation