title: Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)?
abstract: Guillain-Barré syndrome (GBS) is characterized by acute and symmetric flaccid paraparesis and areflexia. Involvement of the central nervous system has been infrequently reported. In the current issue of Clinical Medicine: Case reports, an unusual case of GBS with asymmetric muscle weakness was reported. Corticomotoneuronal dysfunction was invoked as a possible cause for this neurological finding. Reversible blockade of voltage gated Na(+) channels resulting in conduction failure may be a possible pathophysiological mechanism.
authors.affiliation: Department of Neurology, Westmead Hospital, Western Clinical School, University of Sydney, Wentworthville, NSW, 2145, Sydney, Australia. Email: s.vucic@powmri.edu.au.
authors.forename: Steve
authors.initials: S
authors.lastname: Vucic
keywords: Guillain-Barré syndrome; TMS; conduction block