title: Motor and behavioral changes in mice with cisplatin-induced acute renal failure.
abstract: We have previously shown that chronic renal failure in rats induces changes in motor activity and behavior. Similar work on the possible effects of acute renal failure (ARF) induced by cisplatin (CP) is lacking. This is the subject matter of the current work. CP was injected intraperitoneally (i.p.) at a single dose of 20 mg/kg to induce a state of ARF, and three days later, its effects on motor activity, thermal and chemical nociceptive tests, neuromuscular coordination, pentobarbitone-sleeping time, exploration activity and two depression models were investigated. The platinum concentration in the kidneys and brains of mice was also measured. The occurrence of CP-induced ARF was ascertained by standard physiological, biochemical and histo-pathological methods. CP induced all the classical biochemical, physiological and histopathological signs of ARF. The average renal platinum concentration of CP-treated mice was 5.16 ppm, but there was no measurable concentration of platinum in the whole brains. CP treatment significantly decreased motor and exploration activities, and increased immobility time in depression models, suggesting a possible depression-like state. There was also a significant decrease in neuromuscular coordination in CP-treated mice. CP, given at a nephrotoxic dose, induced several adverse motor and behavioral alterations in mice. Further behavioral tests and molecular and biochemical investigations in the brains of mice with CP-induced ARF are warranted.
authors.affiliation: Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman. alibadreldin@hotmail.com, akthmali@squ.edu.om.
authors.forename: B H
authors.initials: BH
authors.lastname: Ali
authors.forename: A
authors.initials: A
authors.lastname: Ramkumar
authors.forename: T T
authors.initials: TT
authors.lastname: Madanagopal
authors.forename: M I
authors.initials: MI
authors.lastname: Waly
authors.forename: M
authors.initials: M
authors.lastname: Tageldin
authors.forename: S
authors.initials: S
authors.lastname: Al-Abri
authors.forename: M
authors.initials: M
authors.lastname: Fahim
authors.forename: J
authors.initials: J
authors.lastname: Yasin
authors.forename: A
authors.initials: A
authors.lastname: Nemmar
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D003863:Depression / Q000139:chemically induced / Q000523:psychology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D011897:Random Allocation
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin