title: Development of strontium and magnesium substituted porous hydroxyapatite/poly(3,4-ethylenedioxythiophene) coating on surgical grade stainless steel and its bioactivity on osteoblast cells.
abstract: The present study deals with the successful development of bilayer coatings by electropolymerisation of poly(3,4-ethylenedioxythiophene) (PEDOT) on surgical grade stainless steel (316L SS) followed by the electrodeposition of strontium (Sr) and magnesium (Mg) substituted porous hydroxyapatite (Sr, Mg-HA). The bilayer coatings were characterised by Fourier transform infrared spectroscopy (FT-IR) and high resolution scanning electron microscopy (HRSEM). Corrosion resistance of the obtained coatings was investigated in Ringer's solution by electrochemical techniques and the results were in good agreement with those obtained from chemical analysis, namely inductively coupled plasma atomic emission spectrometry (ICP-AES). Also, the mechanical and biological properties of the bilayer coatings were analyzed. From the obtained results it was evident that the PEDOT/Sr, Mg-HA bilayer exhibited greater adhesion strength than the Sr, Mg-HA coated 316L SS. In vitro cell adhesion test of the Sr, Mg-HA coating on PEDOT coated specimen is found to be more bioactive compared to that of the single substituted hydroxyapatite (Sr or Mg-HA) on the PEDOT coated 316L SS. Thus, the PEDOT/Sr, Mg-HA bilayer coated 316L SS can serve as a prospective implant material for biomedical applications.
authors.affiliation: Department of Chemistry, Periyar University, Salem 636 011, Tamilnadu, India; Centre for Nanoscience and Nanotechnology, Periyar University, Salem 636 011, Tamilnadu, India. Electronic address: dhanaraj_gopi@yahoo.com.
authors.forename: D
authors.initials: D
authors.lastname: Gopi
authors.affiliation: Department of Chemistry, Periyar University, Salem 636 011, Tamilnadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Ramya
authors.affiliation: Department of Chemistry, Periyar University, Salem 636 011, Tamilnadu, India; Department of Physics, Periyar University, Salem 636 011, Tamilnadu, India.
authors.forename: D
authors.initials: D
authors.lastname: Rajeswari
authors.affiliation: Department of Chemistry, Periyar University, Salem 636 011, Tamilnadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Surendiran
authors.affiliation: Centre for Nanoscience and Nanotechnology, Periyar University, Salem 636 011, Tamilnadu, India; Department of Physics, Periyar University, Salem 636 011, Tamilnadu, India.
authors.forename: L
authors.initials: L
authors.lastname: Kavitha
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D058266:Dielectric Spectroscopy; D017886:Durapatite / Q000737:chemistry*; D055664:Electrochemical Techniques; D006244:Hardness / Q000187:drug effects; D006801:Humans; D008274:Magnesium / Q000494:pharmacology*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D058105:Polymerization / Q000187:drug effects; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D013054:Spectrophotometry, Atomic; D017550:Spectroscopy, Fourier Transform Infrared; D013193:Stainless Steel / Q000494:pharmacology*; D013324:Strontium / Q000494:pharmacology*; D013525:Surgical Instruments
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D020099:Coated Materials, Biocompatible; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D013193:Stainless Steel; D017886:Durapatite; D008274:Magnesium; D013324:Strontium
keywords: Bilayer coatings; Electrodeposition; Polarisation; Poly(3,4-ethylenedioxythiophene); Substituted hydroxyapatite; Surgical grade stainless steel