title: Enantioselective synthesis of 2,3-disubstituted indanones via Pd-catalyzed intramolecular asymmetric allylic alkylation of ketones.
abstract: A Pd-catalyzed intramolecular asymmetric allylic alkylation (AAA) reaction with "hard" carbanions has been developed for the first time, affording 2,3-disubstituted indanones with high diastereo- and enantioselectivities. The transformation of these products into other core structures of natural products has been demonstrated.
authors.affiliation: State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Li
authors.forename: Bao-Hui
authors.initials: BH
authors.lastname: Zheng
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Ding
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Hou
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry; D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D007189:Indans; D007659:Ketones; D010165:Palladium