title: Skin wound healing and scarring: fetal wounds and regenerative restitution.
abstract: The adverse physiological and psychological effects of scars formation after healing of wounds are broad and a major medical problem for patients. In utero, fetal wounds heal in a regenerative manner, though the mechanisms are unknown. Differences in fetal scarless regeneration and adult repair can provide key insight into reduction of scarring therapy. Understanding the cellular and extracellular matrix alterations in excessive adult scarring in comparison to fetal scarless healing may have important implications. Herein, we propose that matrix can be controlled via cellular therapy to resemble a fetal-like matrix that will result in reduced scarring.
authors.affiliation: Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Cecelia C
authors.initials: CC
authors.lastname: Yates
authors.forename: Patricia
authors.initials: P
authors.lastname: Hebda
authors.forename: Alan
authors.initials: A
authors.lastname: Wells
mesh_terms: D017209:Apoptosis / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy; D002921:Cicatrix / Q000517:prevention & control / Q000628:therapy*; D005109:Extracellular Matrix / Q000502:physiology*; D005333:Fetus / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D054367:Receptors, CXCR3 / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000235:genetics / Q000502:physiology*
chemical_list: C515187:CXCR3 protein, human; D054367:Receptors, CXCR3
keywords: CXCR3; ECM; fetal wounds; fibrosis