title: Hepatoprotective prenylaromadendrane-type diterpenes from the gum resin of Boswellia carterii.
abstract: Chemical examination of the exuded gum resin of Boswellia carterii resulted in the isolation of nine new prenylaromadendrane-type diterpenes, boscartols A-I (1-9). The structures of these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, and circular dichroism spectra. Compounds 1-3, 5, 6, 8, and 9 (10 μM) showed moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Yan-gai
authors.initials: YG
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Ren
authors.forename: Ai-guo
authors.initials: AG
authors.lastname: Wang
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Yang
authors.forename: Teng-fei
authors.initials: TF
authors.lastname: Ji
authors.forename: Qin-Ge
authors.initials: QG
authors.lastname: Ma
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Ya-lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D029743:Boswellia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology; D005881:Gingiva / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012116:Resins, Plant / Q000737:chemistry / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D007155:Immunologic Factors; D012116:Resins, Plant; D014315:Triterpenes; D005688:Galactosamine