title: Predictors of cancer risk in the long-term solid-organ transplant recipient.
abstract: Malignancy is increasingly the leading cause of mortality in solid-organ recipients. Cancer incidence among the transplant population is overall threefold to fivefold higher than the general population with poorer outcomes for late-stage disease. Insights into the identification of patients at particular risk of developing a posttransplantation malignancy are imperative to ensure appropriate measures are instigated to reduce associated morbidity and mortality. This review focuses on potential clinical, immunologic, and genetic translational markers aimed at identifying long-term solid-organ transplant patients at high risk of developing cancer.
authors.affiliation: 1 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. 2 Clinical and Experimental Transplantation Group, Central Northern Adelaide Renal and Transplantation Service Australia, North Terrace, Adelaide, South Adelaide. 3 Oxford Transplant Centre, Churchill Hospital, Oxford, UK. 4 Address correspondence to: Dr. Paul Harden, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Level 6, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
authors.forename: Sam N
authors.initials: SN
authors.lastname: Sherston
authors.forename: Robert P
authors.initials: RP
authors.lastname: Carroll
authors.forename: Paul N
authors.initials: PN
authors.lastname: Harden
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Wood
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000401:mortality; D016377:Organ Transplantation / Q000009:adverse effects* / Q000401:mortality; D018570:Risk Assessment; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents