title: Advances in lung preservation.
abstract: After a brief review of conventional lung preservation, this article discusses the rationale behind ex vivo lung perfusion and how it has shifted the paradigm of organ preservation from conventional static cold ischemia to the utilization of functional normothermia, restoring the lung's own metabolism and its reparative processes. Technical aspects and previous clinical experience as well as opportunities to address specific donor organ injuries in a personalized medicine approach are also reviewed.
authors.affiliation: Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, 9N969, Toronto, Ontario M5G 2C4, Canada.
authors.forename: Tiago N
authors.initials: TN
authors.lastname: Machuca
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
mesh_terms: D000818:Animals; D001926:Brain Death; D050377:Cold Ischemia; D003643:Death; D006801:Humans; D008168:Lung; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods* / Q000639:trends; D010477:Perfusion; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000379:methods
keywords: Ex vivo lung perfusion; Lung transplantation; Non–heart beating donor; Organ preservation; Organ procurement