title: Epithelial expression of vanilloid and cannabinoid receptors: a potential role in burning mouth syndrome pathogenesis.
abstract: Burning mouth syndrome (BMS) is an intra-oral burning sensation for which presently no medical or dental causes have been found, and in which the oral mucosa appears normal. It remains an unknown disease for which there is still no long-term treatment. The aim of this study was to assess the epithelial alteration of transient receptor potential vanilloid channel type 1 (TRPV1) and cannabinoid receptors type 1 (CB1) and type 2 (CB2) in the human tongue. The study was performed on eight healthy controls and eight BMS patients. All patients underwent a 3-mm punch biopsy at the anterolateral aspect of the tongue close to the tip. TRPV1, CB1 and CB2 immuno-histochemistry was carried out showing an altered expression of all receptors. In BMS patients there was increased TRPV1, decreased CB1 and increased CB2 expression in tongue epithelial cells also associated with a change in their distribution. It would appear that these receptors are related to BMS. These data could be useful for future characterization of BMS epithelial markers and therapy.
authors.affiliation: Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Borsani
authors.affiliation: Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Majorana
authors.affiliation: Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Marco Angelo
authors.initials: MA
authors.lastname: Cocchi
authors.affiliation: IRCCS Ca' Granda, University of Milan, Milan, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Conti
authors.affiliation: Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Bonadeo
authors.affiliation: Neurological Clinic, University of Brescia, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.affiliation: Immunology and Muscular Pathology Unit, National Neurological Institute "Carlo Besta", Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.affiliation: Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Bardellini
authors.affiliation: Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Rezzani
authors.affiliation: Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. rodella@med.unibs.it.
authors.forename: Luigi Fabrizio
authors.initials: LF
authors.lastname: Rodella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002054:Burning Mouth Syndrome / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D043884:Receptor, Cannabinoid, CB1 / Q000032:analysis / Q000096:biosynthesis*; D043885:Receptor, Cannabinoid, CB2 / Q000032:analysis / Q000096:biosynthesis*; D050916:TRPV Cation Channels / Q000032:analysis / Q000096:biosynthesis*; D014059:Tongue / Q000378:metabolism
chemical_list: C588309:CNR2 protein, human; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human