title: [Association between venous thrombosis and dyslipidemia].
abstract: OBJECTIVE
  Venous and arterial thrombosis, despite being historically considered as distinct conditions, share certain risk factors. Dyslipidemia is a clinical condition with a relatively high prevalence in the population and has been associated with an increased thrombotic risk. Lipids and lipoproteins modulate the expression and/or function of thrombotic, fibrinolytic and rheological factors.
  
  
  METHODS
  We have developed a descriptive, retrospective, comparative, cross-sectional study including a group of 313 patients with venous thromboembolism (VTE). We collected basic demographic data, cardiovascular risk factors and thrombotic complications. All patients were subjected to a lipid profile study with determination of total cholesterol, high density lipoprotein cholesterol (cHDL), low density lipoprotein cholesterol (cLDL) and triglycerides.
  
  
  RESULTS
  The multivariable analysis showed that dyslipidemia was a risk factor for VTE (odds ratio [OR] 3.87, 95% confidence interval [95% CI] 2.72-5.56; P<.0001). Of a total of 313 patients included in the study, 31% (n=97) had a recurrent thrombotic event and 23% (n=72) developed post-thrombotic syndrome. cHDL levels below 35 mg/dl and cLDL levels higher than 180 mg/dl represented risk factors for the development of recurrent thrombosis, OR 3.12 (95% CI 1.35-7.74; P=.008) and OR 2.35 (95% CI 1.24-4.45; P=.008), respectively, and post-thrombotic syndrome, OR 3.44 (95% CI 1.43-8.83; P=.005) and OR 2.35 (95% CI 1.24-4.45; P=.008).
  
  
  CONCLUSIONS
  Our study confirmed the association between dyslipidemia and VTE and showed a risk of thrombosis nearly 4 times higher in individuals with this disease. In addition, alterations in the lipid profile were also related to a higher prevalence of thrombotic complications, recurrence and post-thrombotic syndrome.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España. Electronic address: argarciar@fjd.es.
authors.forename: Aránzazu
authors.initials: A
authors.lastname: García Raso
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ene
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
authors.forename: Carolina
authors.initials: C
authors.lastname: Miranda
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Vidal
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
authors.forename: Raquel
authors.initials: R
authors.lastname: Mata
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.
authors.forename: M Pilar
authors.initials: MP
authors.lastname: Llamas Sillero
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D016017:Odds Ratio; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D019851:Thrombophilia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D014280:Triglycerides / Q000097:blood; D020246:Venous Thrombosis / Q000097:blood / Q000453:epidemiology*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Colesterol unido a lipoproteínas de alta densidad; Colesterol unido a lipoproteínas de baja densidad; Enfermedad tromboembólica venosa; High density lipoprotein cholesterol; Lipid profile; Low density lipoprotein cholesterol; Perfil lipídico; Venous thromboembolism