title: Isocyanide insertion: de novo synthesis of trifluoromethylated phenanthridine derivatives.
abstract: A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Cheng
authors.forename: Heng
authors.initials: H
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shouyun
authors.initials: S
authors.lastname: Yu
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C587963:6-(trifluoromethyl)phenanthridine; D003486:Cyanides; D010617:Phenanthridines