title: [Effect of early intervention of liver-smoothing and blood-activating decoction combined with acupuncture on patients with post-stroke depression].
abstract: To study the effect of early intervention of liver-soothing and Blood-activating decoction combined with acupuncture in improving neurological functions, depressive symptom and life quality of patients with post-stroke depression, and compare with fluoxetine hydrochloride. Specifically, 63 patients with post-stroke depression were randomly divided into the traditional Chinese medicine (TCM) acupuncture group (31 cases) and the western medicine group (32 cases). On the basis of the conventional treatment of the primary disease, the TCM acupuncture group was treated with liver-soothing and blood-activating decoction and acupuncture, while the western medicine group was treated with fluoxetine hydrochloride for four weeks. In the follow-up visit six months later, scores of HAMD, NIHSS and SS-QOL were observed. The scores of HAMD and NIHSS of both groups were significantly decreased (P < 0.01), while the scores of SS-QOL increased significantly, with a notable difference compared with that before the treatment (P < 0.01). Specifically, the TCM acupuncture group's was superior to the western medicine group (P < 0.05). The study suggests that the early intervention of liver-soothing and blood-activating decoction combined with acupuncture on patients with post-stroke depression has the effect in relieving depression symptom and improving neurological functions, thereby improving their quality of life and prognosis.
authors.affiliation: Department of Neurology, Guangzhou Hospital of Integrated Chinese and Western Medicine, Guangzhou 510800, China. hjf5630@163.com
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Hu
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Chen
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Bi
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Yu
authors.forename: Pei-Qun
authors.initials: PQ
authors.lastname: Yang
authors.forename: Zhe-Jiang
authors.initials: ZJ
authors.lastname: Fan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Tian-Fu
authors.initials: TF
authors.lastname: Liu
mesh_terms: D015670:Acupuncture Therapy; D003131:Combined Modality Therapy; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D018479:Early Intervention, Educational; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D020521:Stroke / Q000523:psychology*
chemical_list: D004365:Drugs, Chinese Herbal; D005473:Fluoxetine