title: Sphingolipid homeostasis in the web of metabolic routes.
abstract: Sphingolipids play a key role in cells as structural components of membrane lipid bilayers and signaling molecules implicated in important physiological and pathological processes. Their metabolism is tightly regulated. Mechanisms controlling sphingolipid metabolism are far from being completely understood. However, they already reveal the integration of sphingolipids in the whole metabolic network as signaling devices that coordinate different metabolic pathways. A picture of sphingolipids integrated into metabolic networks might help to understand sphingolipid homeostasis. This review describes recent advances in the regulation of de novo sphingolipid synthesis with a focus on the bridges that exist with other metabolic pathways and the importance of this crosstalk in the control of sphingolipid homeostasis. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
authors.affiliation: Department of Biochemistry and NCCR Chemical Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. Electronic address: Auxiliadora.Aguilera-Romero@unige.ch.
authors.forename: Auxiliadora
authors.initials: A
authors.lastname: Aguilera-Romero
authors.affiliation: Department of Biochemistry and NCCR Chemical Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. Electronic address: Charlotte.Gehin@unige.ch.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gehin
authors.affiliation: Department of Biochemistry and NCCR Chemical Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. Electronic address: howard.riezman@unige.ch.
authors.forename: Howard
authors.initials: H
authors.lastname: Riezman
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D015398:Signal Transduction; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D013107:Sphingolipids
keywords: Eucaryote; Homeostasis; Metabolism; Sphingolipid