title: GSTM1 and GSTT1 null polymorphisms and childhood acute leukemia risk: evidence from 26 case-control studies.
abstract: Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) null polymorphisms and childhood acute leukemia; however, the conclusions remain controversial. We performed an extensive meta-analysis on 26 published case-control studies with a total of 3252 cases and 5024 controls. Crude odds ratios (ORs) with 95% confidence interval were used to assess the strength of association between childhood acute leukemia risk and polymorphisms of GSTM1 and GSTT1. With respect to GSTM1 polymorphism, significantly increased risk of childhood acute leukemia was observed in the overall analysis (OR = 1.30; 95%CI, 1.11-1.51). Furthermore, a stratification analysis showed that the risk of GSTM1 polymorphism are associated with childhood acute leukemia in group of Asians (OR = 1.94; 95%CI, 1.53-2.46), Blacks (OR = 1.76; 95%CI, 1.07-2.91), ALL (OR = 1.33; 95%CI, 1.13-1.58), '< 100 cases and <100 controls' (OR = 1.79; 95%CI, 1.21-2.64), '≥ 100 cases and ≥ 100 controls' (OR = 1.25; 95%CI, 1.02-1.52), and population-based control source (OR = 1.40; 95%CI, 1.15-1.69). With respect to GSTT1 polymorphism, significant association with childhood acute leukemia risk was only found in subgroup of Asian. This meta-analysis supports that GSTM1 null polymorphism is capable of causing childhood acute leukemia susceptibility.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Department of Obstetrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Simin
authors.initials: S
authors.lastname: Zhang
authors.forename: Beilei
authors.initials: B
authors.lastname: Yuan
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Chuncheng
authors.initials: C
authors.lastname: Lu
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ding
authors.forename: Lingqing
authors.initials: L
authors.lastname: Hu
authors.forename: Daozhen
authors.initials: D
authors.lastname: Chen
authors.forename: Jiahao
authors.initials: J
authors.lastname: Sha
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1