title: Retrospective study of neuroblastoma in Chinese neonates from 1994 to 2011: an evaluation of diagnosis, treatments, and prognosis : a 10-year restrospective study of neonatal neuroblastoma.
abstract: OBJECTIVE
  The purpose of the study is to review the clinical features, treatments, and outcomes of neonatal neuroblastoma (NB).
  
  
  METHODS
  A retrospective analysis was performed on 42 patients with NB between January 1994 and December 2011.
  
  
  RESULTS
  MYCN amplification was detected in nine tumor samples. The ratio of unfavorable histology to favorable histology was 1:2 in NB patients. The 5-year overall survival (OS) of NB patients was 85.7 %. The 5-year OS in patients in the operation group was 83.3 %, chemotherapy group was 83.3 %, and the "wait-and-see" group was 100 % (P = 0.04). Overall, the prognosis was favorable, except in patients with elevated MYCN amplification or vanillylmandelic acid.
  
  
  CONCLUSIONS
  NB patients were more sensitive and vulnerable to chemotherapy and operation. The "wait-and-see" strategy should be highlighted in the treatment of NB.
authors.affiliation: Department of Surgery, Children's Hospital, Medical Center of Fudan University, 399 Wang Yuan Road, Shanghai, 201102, People's Republic of China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Shan
authors.initials: S
authors.lastname: Zheng
authors.forename: Lian
authors.initials: L
authors.lastname: Chen
mesh_terms: D002681:China; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D000071447:N-Myc Proto-Oncogene Protein; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal; D014642:Vanilmandelic Acid / Q000378:metabolism
chemical_list: C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D014642:Vanilmandelic Acid