title: Zygomatic bone metastasis as an initial presentation of hepatocellular carcinoma.
abstract: Hepatocellular carcinoma is the most common type of primary liver cancer. It metastasizes via blood or through lymphatic dissemination, most comonly to the lungs, abdominal lymph nodes, and bones. Metastases to the bones of the head and neck region, however, are extremely uncommon. A 70-year-old male was presented with a mass in the left zygomatic region. After the incisional biopsy, the histopathologic and immunohistochemical analysis confirmed a metastasis of hepatocellular carcinoma. An abdominal computerized tomography (CT) scan  revealed a large primary tumor in the right liver lobe. To the best of our knowledge, this is the second case of an isolated zygomatic metastasis as an initial presentation of hepatocellular carcinoma. We also reviewed the literature regarding clinical and histopathologic characteristics of hepatocellular carcinoma that produced metastases to the zygomatic bone and the maxilla.
authors.affiliation: Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. tnada@med.bg.ac.rs.
authors.forename: Nada
authors.initials: N
authors.lastname: Tomanovic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Krstic
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Brasanac
authors.forename: Milovan
authors.initials: M
authors.lastname: Dimitrijevic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Terzic
authors.forename: Ivan
authors.initials: I
authors.lastname: Boricic
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed; D015050:Zygoma