title: Peripheral oxygen extraction in patients with malignant obstructive jaundice.
abstract: Malignant obstructive jaundice is associated with poor aerobic capacity. We measured oxygen consumption and oxygen extraction (arterial-venous oxygen content) in the legs of nine patients during cardiopulmonary exercise testing before pancreaticoduodenectomy. The median (IQR [range]) peak oxygen consumption was 67 (49-77 [32-84])% of predicted. Normal patterns of oxygen extraction were seen with increasing power towards lactate threshold. Near maximal oxygen extraction occurred at peak exercise. Femoral venous oxygen pressure and saturation exceeded baseline values whilst recovering from exercise. These findings suggest that peripheral oxygen extraction is normal during exercise in patients with malignant obstructive jaundice. The primary limitation in oxygen consumption is reduced oxygen delivery.
authors.affiliation: Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Junejo
authors.forename: A K
authors.initials: AK
authors.lastname: Siriwardena
authors.forename: M J
authors.initials: MJ
authors.lastname: Parker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001661:Biliary Tract Neoplasms / Q000150:complications; D015444:Exercise / Q000502:physiology; D005080:Exercise Test; D005260:Female; D005268:Femoral Vein / Q000503:physiopathology; D006801:Humans; D041781:Jaundice, Obstructive / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D010313:Partial Pressure; D010865:Pilot Projects
chemical_list: D019344:Lactic Acid; D010100:Oxygen