title: Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis.
abstract: Multiple sclerosis (MS) is a complex disease influenced by genetic and environmental contributing factors. Endocrine disrupting compounds (EDCs) such as bisphenol A (BPA) affect gene expression and hormone-regulated systems throughout the body. We investigated the effects of BPA on Theiler's-virus induced demyelination (TVID), a mouse model of MS. Perinatal BPA exposure, combined with viral infection, resulted in a decreased level of viral antibodies, accelerated the onset of TVID symptoms, increased inflammation in both the spinal cord and digestive tract, and amplified immune-related gene expression changes induced by viral infection. These results demonstrate the effect of BPA on the trajectory of TVID, and illustrate how multiple factors collectively influence autoimmune disease.
authors.affiliation: Department of Veterinary Integrative Biosciences .
authors.forename: Candice
authors.initials: C
authors.lastname: Brinkmeyer-Langford
authors.forename: Aline
authors.initials: A
authors.lastname: Rodrigues
authors.forename: Kelli J
authors.initials: KJ
authors.lastname: Kochan
authors.forename: Rachel
authors.initials: R
authors.lastname: Haney
authors.forename: Fenan
authors.initials: F
authors.lastname: Rassu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Steelman
authors.forename: Colin
authors.initials: C
authors.lastname: Young
authors.forename: Penny
authors.initials: P
authors.lastname: Riggs
authors.forename: Ralph
authors.initials: R
authors.lastname: Storts
authors.forename: Mary W
authors.initials: MW
authors.lastname: Meagher
authors.forename: C Jane
authors.initials: CJ
authors.lastname: Welsh
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D018188:Cardiovirus Infections / Q000276:immunology; D003106:Colon / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D003711:Demyelinating Diseases / Q000276:immunology / Q000821:virology; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D009103:Multiple Sclerosis / Q000209:etiology* / Q000473:pathology; D009186:Myelin Sheath / Q000276:immunology; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects*; D013116:Spinal Cord / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D017945:Theilovirus / Q000276:immunology; D000098826:Bisphenol A Compounds
chemical_list: D000906:Antibodies; D000914:Antibodies, Viral; D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds