title: Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh.
abstract: A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.0(2,8)]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University , Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Sunan
authors.initials: S
authors.lastname: Jaisamut
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.forename: Chompoonuch
authors.initials: C
authors.lastname: Tancharoen
authors.forename: Supreeya
authors.initials: S
authors.lastname: Yuenyongsawad
authors.forename: Supa
authors.initials: S
authors.lastname: Hannongbua
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
chemical_list: C586162:1-formamido-10(1-2)-abeopupukeanane; C586163:2-formamidopupukeanane; D000970:Antineoplastic Agents; D012717:Sesquiterpenes