title: Editorial: PPIs and recurrent C. difficile infection: no association?
abstract: A rigorously conducted cohort study published in this edition of the American Journal of Gastroenterology shows that the use of a proton-pump inhibitor is not associated with recurrent Clostridium difficile infection among hospitalized patients. This contradicts the findings of previous studies that, however, were at a high risk of bias. Where does the truth lie? Regardless of the answer, it is important that proton-pump inhibitors, not dissimilar to any other drug, are used appropriately.
authors.affiliation: Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Grigorios I
authors.initials: GI
authors.lastname: Leontiadis
mesh_terms: D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D054328:Proton Pump Inhibitors / Q000009:adverse effects*
chemical_list: D054328:Proton Pump Inhibitors