title: Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results.
abstract: BACKGROUND
  The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.
  
  
  METHODS
  Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement.
  
  
  RESULTS
  Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.
  
  
  CONCLUSIONS
  Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.
authors.affiliation: Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany ; REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Shahram
authors.initials: S
authors.lastname: Ghanaati
authors.forename: Mike
authors.initials: M
authors.lastname: Barbeck
authors.forename: Jonas
authors.initials: J
authors.lastname: Lorenz
authors.forename: Stefan
authors.initials: S
authors.lastname: Stuebinger
authors.forename: Oliver
authors.initials: O
authors.lastname: Seitz
authors.forename: Constantin
authors.initials: C
authors.lastname: Landes
authors.forename: Adorján F
authors.initials: AF
authors.lastname: Kovács
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sader
keywords: Bio-oss; NanoBone; bone matrix; bone substitutes; foreign body reaction; hydroxyapatite; oral cancer; sinus floor augmentation