title: Acquired generalized anhidrosis: review of the literature and report of a case with lymphocytic hidradenitis and sialadenitis successfully treated with cyclosporine.
abstract: We report a case of acquired generalized anhidrosis successfully treated with cyclosporine. A skin biopsy showed T cell infiltration around the sweat glands and labial biopsy revealed lymphoplasmacytic infiltration around the minor salivary gland, suggesting an underlying autoimmune disease such as Sjögren's syndrome. Administration of cyclosporine markedly improved the patient's condition and sympathetic skin response; thus cyclosporine may be effective for treating anhidrosis in patients with autoimmune disorders.
authors.affiliation: Tenri Institute of Medical Research, Tenri, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Fujita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hatta
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D016575:Hidradenitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007007:Hypohidrosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D012793:Sialadenitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine