title: The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids.
abstract: BACKGROUND
  Keloids can be quite resistant to conventional methods of treatment. A wide range of treatment modalities exists, often with suboptimal results, recurrences, and adverse events occurring. Laser therapy with the carbon dioxide, erbium:YAG, Q switched frequency doubled neodymium-doped yttrium aluminium garnet (Nd:YAG), and 585/595 nm pulsed dye lasers have all be purported as potential treatment modalities however with limited efficacy and data especially in the skin of color population is limited. We report the successful use of the 300 microsecond 1064 nm Nd:YAG laser in treating keloids in patients with skin types ranging from Fitzpatrick I through VI with special attention in treating skin of color patients.
  
  
  OBJECTIVE
  We examined the use of the 300 microsecond 1064 nanometer (nm) Nd:YAG laser for the treatment keloids in patients with skin types ranging from Fitzpatrick I through VI.
  
  
  METHODS
  A retrospective analysis of treatment efficacy was conducted on 44 patients with keloids. Three separate treatment groups were compared. The groups consisted of: a "control group" in which the whole keloid was only treated with intralesional corticosteroid (triamcinolone 10 mg/cc) (16 patients); a "laser only" group in which the patient's keloid was only treated with the 1064 nm Nd:YAG laser at a fluency of 13 to 18 Joules / centimeter2 (J/cm2), a fixed pulse duration of 300 microseconds, 5 mm spot size, and a total of 2000 pulses (14 patients); and a "combination group" that received both the aforementioned laser therapy and adjuvant intralesional triamcinolone (14 patients).
  
  
  RESULTS
  Patients in the "combination group" treated with the 300 microsecond 1064 nm Nd:YAG laser therapy plus intralesional corticosteroid and the "laser only" group both were observed to have durable clinical reduction in the thickness and erythema of the keloids. These results were shown to be superior to the "control group" whom were only treated with intralesional corticosteroids. Only mild and transient post treatment erythema was noted as an adverse effect.
  
  
  METHODS
  Data analysis was performed using IBM SPSS Statistics 19.0.0 (Armonk, NY). In order to assess the statistical significance of differences in keloid improvement among the three treatment groups, The Kruskal-Wallis test (non-parametric ANOVA test) was applied. The level of statistical significance was set at P< 0.05. A statistically significant difference in keloid improvement was appreciated between treatment groups (P<0.0001).
  
  
  CONCLUSIONS
  A small sample size and the retrospective nature of the analysis are limitations to the study.<BR>
  
  
  CONCLUSIONS
  The 300 microsecond 1064 nm Nd:YAG laser proved effective in improving the clinical appearance of keloids. We recommended this laser protocol in conjunction with intralesional corticosteroids as a treatment option for patients with keloids, especially in the skin of color population. The 1064 nm Nd:YAG laser did not show post inflammatory hyperpigmentation nor hypopigmenatation, which are concerns for skin types IV to VI, and therefore is a suitable option for such patients.
authors.forename: Anthony
authors.initials: A
authors.lastname: Rossi
authors.forename: Rebecca
authors.initials: R
authors.lastname: Lu
authors.forename: Melissa K
authors.initials: MK
authors.lastname: Frey
authors.forename: Takako
authors.initials: T
authors.lastname: Kubota
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Smith
authors.forename: Maritza
authors.initials: M
authors.lastname: Perez
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D017024:Chemotherapy, Adjuvant; D004890:Erythema / Q000209:etiology / Q000628:therapy; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000473:pathology / Q000628:therapy*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D012880:Skin Pigmentation; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide