title: A computer simulation evaluation of the role of mutations in finite populations on the response to directional selection: The generations required to attain maximum genetic variance.
abstract: The role of mutations in finite populations on response to artificial selection was investigated by a computer simulation model designed to mimic the biological model of pupal weight of Tribolium. Given the model, the results showed that with selection about 25-55 generations were needed for genetic variances to reach a maximum value depending on population size, selection intensity, and gene number. When effective population size was larger than 40 or the intensity of selection was high (less than 50% selected), selection had a dramatic effect in reducing the time to approach the maximum point of genetic variance. Furthermore, the genetic variance after that point often declined as a function of selection instead of remaining at a steady state in the subsequent generations.
authors.affiliation: Department of Genetics and Cell Biology, 270 Bioscience Center, University of Minnesota, 55108, St Paul, MN, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Li
authors.forename: F D
authors.initials: FD
authors.lastname: Enfield