title: The self-assembly of cystine-bridged γ-peptide-based cyclic peptide-dendron hybrids.
abstract: Novel cystine-bridged γ-peptide-based cyclic peptide-dendron hybrids have been synthesized by oxidative coupling between two cysteine residues of the linear peptides via the formation of disulfide bonds in high yields. The self-assembly of the hybrids was studied by FT-IR, (1)H NMR, TEM, and AFM analyses which indicate that the nanotube was constructed through intermolecular hydrogen-bonding of the hydrophobic cyclic peptide moieties and possesses amphiphilic property by conjugating a hydrophilic dendron on the exterior of the cyclic peptide ring. The diameters of nanofibers that consisted of nanotubes depend on the employed solvent in the self-assembly process, and uniform filaments formed from double amphiphilic nanotubes via hydrophobic interactions between their hydrophobic faces have been observed in water as well as in aqueous solutions.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Lin
authors.forename: Liangchun
authors.initials: L
authors.lastname: Li
authors.forename: Yujin
authors.initials: Y
authors.lastname: Yang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhan
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhou
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Wang
authors.forename: Jingen
authors.initials: J
authors.lastname: Deng
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D003553:Cystine / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D004220:Disulfides; D010456:Peptides, Cyclic; C501244:dendron; D003553:Cystine