title: Soluble and reusable poly(norbornene) supports with high loading capacities for peptide synthesis.
abstract: Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6-1.1 mmol/g) onto the support in high yields (83-98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41-66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai - 600036, Tamil Nadu, India.
authors.forename: Nimmashetti
authors.initials: N
authors.lastname: Naganna
authors.forename: Nandita
authors.initials: N
authors.lastname: Madhavan
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010969:Plastics / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D010455:Peptides; D010969:Plastics; D012997:Solvents; C071464:polynorbornen; D011092:Polyethylene Glycols