title: The role of H. pylori in the development of laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  This study aims to investigate the possible role of H. pylori as a cause of laryngeal squamous cell carcinoma.
  
  
  METHODS
  This controlled study was performed with 31 consecutive laryngeal cancer and 28 cancer-free patients who underwent direct laryngoscopy and biopsy of laryngeal lesions. To document the previous H. pylori infection, serological analysis of the antibody titers was done. Immunohistochemical analyses were applied to the tissue samples.
  
  
  RESULTS
  Serology was found positive at the 90.3% of the laryngeal cancer patients and 96.4% of the benign group. There were no statistically significant differences between the two groups (P > 0.05). Immunohistochemical analysis results were determined as negative at all of the specimens of laryngeal cancer patients and patients with benign lesions.
  
  
  CONCLUSIONS
  There were no signs of colonization of H. pylori in laryngeal tissues of both groups' patients. It is thought that no relationship exists between the H. pylori infection and laryngeal squamous cell carcinoma.
authors.affiliation: Department of Otorhinolaryngology, Niğde State Hospital, Nigde Devlet Hastanesi, KBB Klinigi, 51000 Nigde, Turkey.
authors.forename: Raşan
authors.initials: R
authors.lastname: Genç
authors.forename: Sedat
authors.initials: S
authors.lastname: Çağlı
authors.forename: İmdat
authors.initials: İ
authors.lastname: Yüce
authors.forename: Alperen
authors.initials: A
authors.lastname: Vural
authors.forename: Hacı
authors.initials: H
authors.lastname: Okuducu
authors.forename: Tahir
authors.initials: T
authors.lastname: Patıroğlu
authors.forename: Ercihan
authors.initials: E
authors.lastname: Güney
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000382:microbiology*; D016022:Case-Control Studies; D005260:Female; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000382:microbiology*; D008297:Male; D008875:Middle Aged