title: Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway.
abstract: Renal cell carcinoma (RCC) is the most common solid cancer of the adult kidney and the majority of RCC cases are detected accidentally. This reality and the nonexistence of a standard screening test contribute to the fact that one third of patients are diagnosed with local invasive disease or metastatic disease. miRNAs are a family of small ncRNAs that regulate gene expression and have been identified as key regulators in many biological processes including cell development, differentiation, apoptosis and proliferation. The EGF receptor signaling pathway is usually deregulated in cancer and it is suggested to have an important role in RCC. Further studies are needed to characterize deregulation of this pathway during RCC development. In this review we highlight some potential miRNAs that could be involved in the modulation of the EGF receptor pathway and consequently in RCC development.
authors.affiliation: Molecular Oncology Group, Portuguese Institute of Oncology, Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal.
authors.forename: Francisca
authors.initials: F
authors.lastname: Dias
authors.forename: Ana L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Juliana I
authors.initials: JI
authors.lastname: Santos
authors.forename: Mónica
authors.initials: M
authors.lastname: Gomes
authors.forename: Augusto
authors.initials: A
authors.lastname: Nogueira
authors.forename: Joana
authors.initials: J
authors.lastname: Assis
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
mesh_terms: D017209:Apoptosis; D063646:Carcinogenesis; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics
chemical_list: D035683:MicroRNAs; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C512478:EGFR protein, human; D066246:ErbB Receptors; C497446:VHL protein, human