title: Primary multicentric angiosarcoma of bone: true entity or metastases from an unknown primary? Value of comparative genomic hybridization on paraffin embedded tissues.
abstract: Multicentric primary angiosarcoma of bone has been described as a distinct entity from bone metastases from angiosarcoma. Bone angiosarcoma accounts for less than 1% of sarcomas. It has dismal prognosis overall, but the multicentric expression does not confer worse prognosis. We describe the case of an old male with bone angiosarcoma of the extremities with multicentric presentation. He soon after had soft tissue angiosarcoma of the head and neck. Histology and immunohistochemistry were consistent with the diagnosis of high-grade angiosarcoma. Comparative genomic hybridization on paraffin-embedded samples of the bone and head and neck samples suggested additional abnormalities in the bone fragment, thus suggesting than bone lesions were indeed metastatic from his head and neck angiosarcoma; although these preliminary analyses warrant confirmation in other similar rare cases. The patient died after 3 years of relapsed acute leukemia with progressive angiosarcoma.
authors.affiliation: Department of Radiation Oncology, Center Antoine-Lacassagne , Nice.
authors.forename: Juliette
authors.initials: J
authors.lastname: Thariat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Peyrottes
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chibon
authors.forename: Maxime
authors.initials: M
authors.lastname: Benchetrit
authors.forename: Esma
authors.initials: E
authors.lastname: Saada
authors.forename: Lauris
authors.initials: L
authors.lastname: Gastaud
authors.forename: Olivier
authors.initials: O
authors.lastname: Dassonville
authors.forename: Antoine
authors.initials: A
authors.lastname: Iannessi
authors.forename: Antione
authors.initials: A
authors.lastname: Thyss
keywords: CGH; angiosarcoma; bone; metastases; multicentric; multifocal