title: Changes in serum interleukin-33 levels in patients with acute cerebral infarction.
abstract: Inflammation is widely considered to be involved in the pathogenesis of cerebral ischemic injury. The balance between inflammatory and anti-inflammatory factors significantly affects the prognosis of patients with cerebral infarction. Interleukin-33 (IL-33), a newly identified member of the interkeukin-1 superfamily, has been found to play very important roles in the inflammation of several human diseases including asthma, inflammatory bowel disease, and central nervous system inflammation. To our knowledge its role in the pathology of acute cerebral infarction has not yet been reported. In this study, we demonstrated that serum IL-33 levels were significantly increased in patients with acute cerebral infarction compared to control patients without acute cerebral infarction. Furthermore, serum IL-33 levels increased with the infarction volume. Our study suggests that IL-33 may be involved in the pathogenesis and/or progression of acute cerebral infarction.
authors.affiliation: Department of Neurology, First Hospital, Jilin University, 71 Xinmin Street, Chaoyang District, Changchun 130021, Jilin, China.
authors.forename: Jingyao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, First Hospital, Jilin University, 71 Xinmin Street, Chaoyang District, Changchun 130021, Jilin, China.
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Stomatology, 461 Hospital, People's Liberation Army, Changchun, Jilin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurology, First Hospital, Jilin University, 71 Xinmin Street, Chaoyang District, Changchun 130021, Jilin, China. Electronic address: xiaohua208@sina.com.
authors.forename: Chunkui
authors.initials: C
authors.lastname: Zhou
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011859:Radiography
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins
keywords: Acute cerebral infarction; Cytokine; Inflammation; Interleukin-33