title: Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer.
abstract: The study objective was to determine the presence of MMP-7 in cancer tissue in correlation with its serum level in patients diagnosed with colorectal cancer (CRC). In 45 patients with CRC, MMP-7 expression was assessed immunohistochemically on FFPE slides in tumours (N = 37) and in the corresponding surgical margin sample. MMP-7 serum level was measured preoperatively. The expression of MMP-7 in cancer tissue was much stronger as compared to the normal intestinal mucosa. Also the level of MMP-7 in the serum of CRC patients was higher than in healthy subjects (N = 24) (p < 0.01). The tumour located in the colon showed higher expression of MMP-7 than CRCs located in the rectum (p < 0.05), whereas the higher MMP-7 serum level showed correlation with older age (p = 0.005), tumour size less than 5 cm (p < 0.05), higher Dukes' stage (p < 0.05) and distant metastases (p < 0.05). The increased serum level of MMP-7 in CRC patients may indicate the presence of distant metastases.
authors.affiliation: Medical University of Bialystok. pryczynicz.anna@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Pryczynicz
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gryko
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Niewiarowska
authors.forename: Violetta
authors.initials: V
authors.lastname: Dymicka-Piekarska
authors.forename: Marek
authors.initials: M
authors.lastname: Ustymowicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Hawryluk
authors.forename: Dariusz
authors.initials: D
authors.lastname: Cepowicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Borsuk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kemona
authors.forename: Waldemar
authors.initials: W
authors.lastname: Famulski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Guzinska-Ustymowicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7