title: Anaplastic renal carcinoma expressing SV40 T antigen in a female TRAMP mouse.
abstract: An 8-mo-old female transgenic adenocarcinoma of the mouse prostate (C57BL/6-Tg(TRAMP)8247Ng/J) mouse presented with abdominal distention, lethargy, and serosanguineous vaginal discharge. A large primary renal tumor with metastases to lung and liver was present at necropsy. The tumor was composed of poorly differentiated and crowded epithelial cells forming ducts, acini, and cribriform patterns, with comedonecrosis and frequent bizarre mitoses. Immunohistochemistry revealed that neoplastic cells expressed nuclear SV40 T antigen, confirming aberrant expression of the transgene. In addition, cells were positive for pancytokeratin and negative for synaptophysin and estrogen and progesterone receptors. This report details the first transgene-induced tumor in a female TRAMP mouse.
authors.affiliation: Department of Comparative Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Goodwin
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhong
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Abendroth
authors.forename: Lindsay K
authors.initials: LK
authors.lastname: Ward-Kavanagh
authors.forename: Todd D
authors.initials: TD
authors.lastname: Schell
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Cooper
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D002277:Carcinoma / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004195:Disease Models, Animal; D005260:Female; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011471:Prostatic Neoplasms / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D012376:Rodent Diseases / Q000235:genetics / Q000473:pathology*