title: Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis.
abstract: There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources such as allogeneic umbilical cord-derived cells may provide a more accessible and practical supply of cells for transplantation. In this case report we present the treatment of aggressive multiple sclerosis with multiple allogenic human umbilical cord-derived mesenchymal stem cell and autologous bone marrow-derived mesenchymal stem cells over a 4 y period. The treatments were tolerated well with no significant adverse events. Clinical and radiological disease appeared to be suppressed following the treatments and support the expansion of mesenchymal stem cell transplantation into clinical trials as a potential novel therapy for patients with aggressive multiple sclerosis.
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Zong-liu
authors.initials: ZL
authors.lastname: Hou
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Xi-Hong
authors.initials: XH
authors.lastname: Mao
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Chuan-yu
authors.initials: CY
authors.lastname: Wei
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Ming-yao
authors.initials: MY
authors.lastname: Meng
authors.affiliation: Yan-an Hospital; Kunming Medical University; Kunming, PR China.
authors.forename: Yun-hong
authors.initials: YH
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Stem Cell and Regenerative Medicine; Institute of Molecular and Clinical Medicine; Kunming Medical College; Kunming, PR China; Department of Anatomy and Developmental Biology; Monash University; Clayton, Victoria, Australia.
authors.forename: Zara
authors.initials: Z
authors.lastname: Zhuyun Yang
authors.affiliation: The Key Laboratory of Stem Cell and Regenerative Medicine; Institute of Molecular and Clinical Medicine; Kunming Medical College; Kunming, PR China; Department of Anatomy and Developmental Biology; Monash University; Clayton, Victoria, Australia.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Australian Regenerative Medicine Institute; Monash University; Clayton, VIC, Australia.
authors.forename: Martin
authors.initials: M
authors.lastname: Short
authors.affiliation: Department of Anatomy and Developmental Biology; Monash University; Clayton, Victoria, Australia.
authors.forename: Claude
authors.initials: C
authors.lastname: Bernard
authors.affiliation: The Key Laboratory of Stem Cell and Regenerative Medicine; Institute of Molecular and Clinical Medicine; Kunming Medical College; Kunming, PR China; Australian Regenerative Medicine Institute; Monash University; Clayton, VIC, Australia.
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Xiao
mesh_terms: D000328:Adult; D001854:Bone Marrow Cells / Q000166:cytology; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D012038:Regeneration; D014470:Umbilical Cord / Q000166:cytology
keywords: MS; axon; mesenchymal stem cell; multiple sclerosis; myelination; regeneration; stem cells; transplantation