title: The central dogma decentralized: new perspectives on RNA function and local translation in neurons.
abstract: The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.
authors.affiliation: Department of Physiology Development and Neuroscience, Anatomy Building, Downing Street, University of Cambridge, Cambridge CB2 3DY, UK. Electronic address: ceh33@cam.ac.uk.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Holt
authors.forename: Erin M
authors.initials: EM
authors.lastname: Schuman
mesh_terms: D000818:Animals; D020439:Growth Cones / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology*; D014176:Protein Biosynthesis / Q000502:physiology*; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D012313:RNA