title: The role of maternal care in shaping CNS function.
abstract: Maternal care involves the consistent and coordinated expression of a variety of behaviours over an extended period of time, and adverse changes in maternal care can have profound impacts on the CNS and behaviour of offspring. This complex behavioural pattern depends on a number of integrated neuroendocrine mechanisms. This review will discuss the use of animal models in the study of the role of maternal care in shaping CNS function, the contributions of corticosteroid releasing hormone, vasopressin, oxytocin, and prolactin in this process, the molecular mechanisms involved, and the translational relevance of this research.
authors.affiliation: Tufts University Cummings School of Veterinary Medicine, Biomedical Sciences, 200 Wesboro Rd., Peabody Pavilion, North Grafton, MA 01536, United States. Electronic address: bcnephew@aol.com.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nephew
authors.forename: Chris
authors.initials: C
authors.lastname: Murgatroyd
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008425:Maternal Behavior / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009490:Neurosecretory Systems / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011388:Prolactin / Q000502:physiology; D051381:Rats; D014667:Vasopressins / Q000502:physiology
chemical_list: D014667:Vasopressins; D010121:Oxytocin; D011388:Prolactin; D003346:Corticotropin-Releasing Hormone
keywords: Anxiety; Corticosteroid releasing hormone; Depression; Epigenetics; Lactation; Maternal care; Nursing; Oxytocin; Prolactin; Vasopressin