title: Predicting brain metastases of breast cancer based on serum S100B and serum HER2.
abstract: Brain metastases are a major cause of morbidity and mortality in breast cancer. The aim of the current study was to evaluate the prediction of brain metastases based on serum S100B and human epidermal growth factor receptor 2 (HER2). A total of 107 breast cancer patients were included in the current study from two prospective cohort studies with either elevated serum HER2 levels >15 ng/ml or brain metastases verified by magnetic resonance imaging (MRI) or computer tomography (CT). Following the exclusion of six patients, the remaining 101 patients were divided into two groups: Group 0 (n=55), patients with normal MRI results; and group 1 (n=46), patients with brain metastases. The levels of serum S100B and HER2 in the two groups were analyzed prior to MRI or CT of the brain, and no significant differences were identified in the serum HER2 (P=0.060) or S100B levels (P=0.623) between the groups. The univariate analysis of prognostic factors for brain metastases showed a significant correlation with systemic disease (P<0.001), axillary lymph node metastases (P=0.001) and serum HER2 >30 ng/ml (P=0.002). Only systemic disease (P<0.001) remained statistically significant in the multivariate analysis. In conclusion, serum levels of S100B and HER2 did not predict the risk of brain metastases. In the multivariate analysis, brain metastases were only found to correlate with systemic disease. However, in the univariate analysis, serum HER2 levels >30 ng/ml were identified to correlate with increased risk of brain metastases, which calls for further investigation.
authors.affiliation: Faculty of Health Sciences, University of Southern Denmark, Odense 5000, Denmark ; Department of Oncology, Vejle Hospital, Vejle 7100, Denmark.
authors.forename: Troels
authors.initials: T
authors.lastname: Bechmann
authors.forename: Jonna Skov
authors.initials: JS
authors.lastname: Madsen
authors.forename: Ivan
authors.initials: I
authors.lastname: Brandslund
authors.forename: Erik Dalsgaard
authors.initials: ED
authors.lastname: Lund
authors.forename: Tina
authors.initials: T
authors.lastname: Ormstrup
authors.forename: Erik Hugger
authors.initials: EH
authors.lastname: Jakobsen
authors.forename: Anne Marie Bak
authors.initials: AM
authors.lastname: Jylling
authors.forename: Karina Dahl
authors.initials: KD
authors.lastname: Steffensen
authors.forename: Anders
authors.initials: A
authors.lastname: Jakobsen
keywords: HER2/neu; brain metastases; breast cancer; serum S100B; serum human epidermal growth factor receptor 2