title: Fibroblasts and the ground they walk on.
abstract: Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.
authors.affiliation: Department of Environmental Health, Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Tschumperlin
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D014945:Wound Healing