title: Thia-analogues of amino acids synthesis of peptide derivatives containing 3-thia-analogues of amino acids.
abstract: N-Protected dipeptides containing L-3-thia-analogues of phenylalanine, p-nitro-phenylalanine, lysine and leucine respectively were prepared applying an enantioselective enzymatic reaction step. Racemic synthetic intermediates of the type acyl-NH-CH(R(1))-CO-D,L-NH-CH(S-R(2))-COOBzl were selectively deprotected at the C-terminus by enzymatic hydrolysis using thermitase or trypsin.
authors.affiliation: Institute of Biochemistry, Medical Faculty, Martin-Luther-University, P.O. Box 302, D-O-4010, Halle, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Hermann
authors.forename: H
authors.initials: H
authors.lastname: Baumann
authors.forename: C
authors.initials: C
authors.lastname: Herrnstadt
authors.forename: D
authors.initials: D
authors.lastname: Glanz