title: Biomarkers of arsenic exposure and effects in a Canadian rural population exposed through groundwater consumption.
abstract: Drinking water intake of arsenic (As) from private wells may represent a significant exposure pathway and induce oxidative DNA damage. We measured total As concentrations in hair and nails, and concentrations of the different species of As and its metabolites as well as 8-OHdG in urine of 110 non-smoking adults living in a rural region of the Province of Quebec, Canada. Significant differences in exposure biomarker levels were observed between individuals consuming drinking water with As levels of≤1.0,>1.0 -≤10 and>10 μg/l. Multivariate linear regression analysis also showed a significant relationship between estimated daily drinking water intakes of As and biomarker levels. Conversely, 8-OHdG levels were not significantly related to daily drinking water intakes of As or to hair, nail or urinary exposure biomarker levels, according to multivariate linear regression analysis. Even at the relatively low levels of As found in well water of our participants, water consumption significantly increases their body load of As, as confirmed by multiple matrix measurements, which reflected exposure over different time frames. However, this increased internal As dose was not associated with higher oxidative damage to DNA as reflected by urinary 8-OHdG levels.
authors.affiliation: 1] Institut national de santé publique du Québec (INSPQ), Montreal, Quebec, Canada [2] Department of Environmental and Occupational Health, Chair of Toxicological Risk Assessment and Management and Institut de recherche en santé publique, University of Montreal, Main Station, Montreal, Quebec, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Normandin
authors.affiliation: Axe Santé publique et pratiques optimales en santé, Centre de recherche du CHU Québec/INSPQ, Wolfe, Quebec, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Ayotte
authors.affiliation: Axe Santé publique et pratiques optimales en santé, Centre de recherche du CHU Québec/INSPQ, Wolfe, Quebec, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Levallois
authors.affiliation: Department of Environmental and Occupational Health, Chair of Toxicological Risk Assessment and Management and Institut de recherche en santé publique, University of Montreal, Main Station, Montreal, Quebec, Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Ibanez
authors.affiliation: Axe Santé publique et pratiques optimales en santé, Centre de recherche du CHU Québec/INSPQ, Wolfe, Quebec, Canada.
authors.forename: Marilène
authors.initials: M
authors.lastname: Courteau
authors.affiliation: Department of Engineering Physics, École Polytechnique de Montréal, Montréal, Québec, Canada.
authors.forename: Greg
authors.initials: G
authors.lastname: Kennedy
authors.affiliation: Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Lydia
authors.initials: L
authors.lastname: Chen
authors.affiliation: Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: X Chris
authors.initials: XC
authors.lastname: Le
authors.affiliation: Department of Environmental and Occupational Health, Chair of Toxicological Risk Assessment and Management and Institut de recherche en santé publique, University of Montreal, Main Station, Montreal, Quebec, Canada.
authors.forename: Michèle
authors.initials: M
authors.lastname: Bouchard
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis*; D002170:Canada; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012424:Rural Population; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D001151:Arsenic