title: Psychosis with obsessive-compulsive symptoms in tuberous sclerosis.
abstract: We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne, Level 2, John Cade Building, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3050, Australia. Electronic address: islam_k_hassan@hotmail.com.
authors.forename: Islam K
authors.initials: IK
authors.lastname: Hassan
authors.affiliation: Academic Unit of Psychological and Addiction Medicine, Australian National University Medical School, Canberra Hospital, Canberra, ACT, Australia.
authors.forename: Jeffrey C L
authors.initials: JC
authors.lastname: Looi
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne, Level 2, John Cade Building, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3050, Australia.
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.affiliation: Department of Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Gaillard
authors.affiliation: Department of Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Elaine H
authors.initials: EH
authors.lastname: Lui
authors.affiliation: Department of Neurology, Melbourne Brain Centre, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
authors.affiliation: Department of Neurology, Melbourne Brain Centre, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: French
authors.affiliation: Department of Neurology, Melbourne Brain Centre, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Campbell
authors.initials: C
authors.lastname: Le Heron
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne, Level 2, John Cade Building, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3050, Australia.
authors.forename: Sophia J
authors.initials: SJ
authors.lastname: Adams
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D014402:Tuberous Sclerosis / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology
keywords: Epilepsy; Neuropsychiatry; Obsessive compulsive disorder; Psychosis; Tuberous sclerosis