title: Antipsychotics' effects on blood levels of cytokines in schizophrenia: a meta-analysis.
abstract: OBJECTIVE
  Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined.
  
  
  METHODS
  A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment.
  
  
  RESULTS
  We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1β and interferon-γ.
  
  
  CONCLUSIONS
  These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.
authors.affiliation: Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada.
authors.forename: Valérie
authors.initials: V
authors.lastname: Tourjman
authors.forename: Édouard
authors.initials: É
authors.lastname: Kouassi
authors.forename: Marie-Ève
authors.initials: MÈ
authors.lastname: Koué
authors.forename: Matteo
authors.initials: M
authors.lastname: Rocchetti
authors.forename: Simon
authors.initials: S
authors.lastname: Fortin-Fournier
authors.forename: Paolo
authors.initials: P
authors.lastname: Fusar-Poli
authors.forename: Stéphane
authors.initials: S
authors.lastname: Potvin
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood* / Q000627:therapeutic use*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D019317:Evidence-Based Medicine; D006801:Humans; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D016207:Cytokines
keywords: Antipsychotic drugs; Cytokines; Inflammation; Schizophrenia