title: Cerebral radiation injury and changes in the brain tissues of rat models with glioma.
abstract: Cerebral radiation injury (CRI) is a crucial and common complication of radiotherapy for patients with glioma. In the study, we aimed to investigate the changes in the diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) and the histological changes in the brain tissues of mice models with glioma. After the tumor cell seeding, there was an obvious increase in the proportion of cellular nucleus in the brain tissues of rat models with glioma. There was also an obvious increase in the microvascular density (MVD) in the brain tissues of rat models with glioma. There was a linear correlation between the mean apparent diffusion coefficient value and the proportion of cellular nucleus in the brain tissues of rat models with glioma (P < 0.05). There was also a linear correlation between the maximal relative cerebral volume and MVD count in the brain tissues of rat models with glioma (P < 0.01). Therefore, the changes in the DWI and PWI are related with the histological changes in the brain tissues of glioma, and the finding may help us make a distinction between postoperative recurrent glioma and CRI.
authors.affiliation: Department of Radiology, the Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sha
authors.forename: Qian
authors.initials: Q
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Lv
authors.forename: Guoguang
authors.initials: G
authors.lastname: Fan
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D038524:Diffusion Magnetic Resonance Imaging; D004195:Disease Models, Animal; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000532:radiotherapy; D018810:Magnetic Resonance Angiography; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley