title: [Hemorrhagic complications of chronic anticoagulant treatment in a single intensive care unit].
abstract: BACKGROUND
  There are well defined indications in which chronic anticoagulant treatment has been widely applied. However, complications of this therapy are less discussed, although these complications may lead to serious or even fatal consequences.
  
  
  OBJECTIVE
  The aim of the authors was to analyze data of patients admitted to their multidisciplinary intensive care unit for complications of chronic anticoagulant therapy between January 1, 2006 and December 31, 2011.
  
  
  METHODS
  Data of 73 patients admitted for serious hemorrhagic complications of chronic anticoagulant therapy were retrospectively analysed.
  
  
  RESULTS
  Of the 73 patients, 63 patients had intracranial bleeding, most of them with traumatic origin. A few patients with other hemorrhagic complications such as spinal hematoma, gastrointestinal bleeding, hemorrhagic cystitis, hemothorax and intraabdominal bleeding were also noted. The INR values were out of therapeutic range in 43 patients. The mortality of patients was very high in spite of complex intensive care; 49 of the 73 patients (75.5%) died due to hemorrhagic complications.
  
  
  CONCLUSIONS
  Due to the high proportion of traumatic origin, the large number of out-of-range INR, and the high mortality, the authors strongly believe that regular patient follow-up, transmission of detailed information, and time-to-time reevaluation of the indications and contraindications of chronic anticoagulant therapy could help to decrease the number of serious and fatal complications of chronic anticoagulant therapy.
authors.affiliation: Szent János Kórház és Észak-budai Egyesített Kórházak Központi Aneszteziológiai és Intenzív Terápiás Osztály Budapest Diós árok 1-3. 1125.
authors.forename: Ilona
authors.initials: I
authors.lastname: Tinyei
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kocsi
authors.forename: István
authors.initials: I
authors.lastname: Pénzes
authors.forename: Tibor
authors.initials: T
authors.lastname: Nyulasi
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D003422:Critical Care / Q000379:methods*; D003556:Cystitis / Q000139:chemically induced / Q000401:mortality; D004334:Drug Administration Schedule; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000401:mortality; D006470:Hemorrhage / Q000139:chemically induced* / Q000401:mortality*; D006491:Hemothorax / Q000139:chemically induced / Q000401:mortality; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007362:Intensive Care Units; D019934:International Normalized Ratio; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D000074:Acenocoumarol
keywords: chronic anticoagulant; complications; hemorrhage; intensive care; intenzív ellátás; krónikus antikoagulálás; szövődmény; vérzés