title: Subchronic dermal exposure to T-2 toxin produces cardiac toxicity in experimental Wistar rats.
abstract: Our study aimed to determine the cardiac toxicities of T-2 toxin, a representative mycotoxin that frequently contaminates maize, cereals, and other agricultural products, harvested and stored under damp and cold conditions. Dermal exposure to T-2 toxin caused severe cardiotoxicity in experimental Wistar rats. Electrocardiography studies showed the conduction abnormalities including prolongation of the QT and corrected QT interval, shortening of the PR interval, and tachycardia. Biochemical studies also reported the toxicity of T-2 toxin. T-2 toxin induced acute cardiotoxicity in rats and characterized by significant (p < 0.05) elevation of serum troponin I, creatine kinase (CK) isoenzyme MB, CK isoenzyme NAC, and lactate dehydrogenase as compared to control rats. It is concluded that cardiotoxicity effects of T-2 toxin are thought to be due to direct action on electrocardiac potentials and biochemical changes.
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India chattopadhyay.drdo@gmail.com.
authors.forename: Pronobesh
authors.initials: P
authors.lastname: Chattopadhyay
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Johirul
authors.initials: J
authors.lastname: Islam
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Danswrang
authors.initials: D
authors.lastname: Goyary
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Agnihotri
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Sanjev
authors.initials: S
authors.lastname: Karmakar
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Subham
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Directorate of Life Sciences, Defence Research and Development Organization, New Delhi, India.
authors.forename: Lokendra
authors.initials: L
authors.lastname: Singh
authors.affiliation: Pharmaceutical Technology Division, Defence Research Laboratory, Tezpur, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Veer
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D066126:Cardiotoxicity / Q000473:pathology* / Q000503:physiopathology*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013605:T-2 Toxin / Q000008:administration & dosage / Q000633:toxicity*; D059550:Toxicity Tests, Subchronic
chemical_list: D013605:T-2 Toxin
keywords: ECG; T-2 toxin; cardiac marker enzymes; cardiomyopathy