title: The potential roles of T-type Ca2+ channels in motor coordination.
abstract: Specific behavioral patterns are expressed by complex combinations of muscle coordination. Tremors are simple behavioral patterns and are the focus of studies investigating motor coordination mechanisms in the brain. T-type Ca(2+) channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits. Despite substantial evidence that T-type Ca(2+) channels mediate pathological tremors, their roles in physiological motor coordination and behavior remain unknown. Here, we review recent progress in understanding the roles that T-type Ca(2+) channels play under pathological conditions, and discuss the potential relevance of these channels in mediating physiological motor coordination.
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon, South Korea.
authors.forename: Young-Gyun
authors.initials: YG
authors.lastname: Park
authors.forename: Jeongjin
authors.initials: J
authors.lastname: Kim
authors.forename: Daesoo
authors.initials: D
authors.lastname: Kim
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D020747:Calcium Channels, T-Type / Q000378:metabolism*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology; D014202:Tremor / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D020747:Calcium Channels, T-Type
keywords: T-type Ca2+ channels; inferior olive; motor coordination; thalamocortical neurons; tremors