title: Multiple complex congenital malformations in a rabbit kit (Oryctolagus cuniculi).
abstract: Congenital malformations may occur during early embryogenesis in cases of genetic abnormalities or various environmental factors. Affected subjects most often have only one or 2 abnormalities; subjects rarely have several unrelated congenital defects. Here we describe a case of a stillborn New Zealand white rabbit with multiple complex congenital malformations, including synophthalmia, holoprosencephaly, gastroschisis, and a supernumerary hindlimb, among other anomalies. There was no historical exposure to teratogens or other known environmental causes. Although not confirmed, this case was most likely a rare spontaneous genetic event.
authors.affiliation: Department of Comparative Medicine, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Booth
authors.forename: Xuwen
authors.initials: X
authors.lastname: Peng
authors.forename: Jennifer
authors.initials: J
authors.lastname: Baccon
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Cooper
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D020139:Gastroschisis / Q000473:pathology / Q000662:veterinary; D016142:Holoprosencephaly / Q000473:pathology / Q000662:veterinary; D017880:Limb Deformities, Congenital / Q000473:pathology / Q000662:veterinary; D011817:Rabbits / Q000002:abnormalities*; D050497:Stillbirth / Q000662:veterinary