title: (13)C-Leucine-tracer-technique for in-vivo measurement of amino acids' metabolism by human colon carcinomas.
abstract: Own investigations on in-vivo tumor metabolism of the malignant human colon tumor showed a significant uptake of branched chain amino acids by the tumor itself. To study the quantitative tumor protein metabolism ("compartment "tumor") the(13)C-leucine-tracer-technique was modified.Beside the common(13)C-leucine-breath-test we measured also the AV-differences of(13)C-leucine,(13)C-ketoisocaproate and(13)CO2. The "Tumorblood flow" was measured by "venous-outflow-technique" as well as the tumor mass.In this way it is possible to get quantitative results in substrate exchange of branched chain amino acids in malignant human colon tumors.
authors.affiliation: Surgical Clinic, University Heidelberg, Mannheim, Federal Republic of Germany.
authors.forename: E
authors.initials: E
authors.lastname: Hagmüller
authors.forename: H J
authors.initials: HJ
authors.lastname: Günther
authors.forename: H D
authors.initials: HD
authors.lastname: Saeger
authors.forename: H
authors.initials: H
authors.lastname: Kolmar
authors.forename: J P
authors.initials: JP
authors.lastname: Striebel
authors.forename: Y
authors.initials: Y
authors.lastname: Ghoos