title: Simultaneous determination of dopamine and uric acid using layer-by-layer graphene and chitosan assembled multilayer films.
abstract: Multilayer films containing graphene (Gr) and chitosan (CS) were prepared on glassy carbon electrodes with layer-by-layer (LBL) assembly technique. After being characterized with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM), the electrochemical sensor based on the resulted films was developed to simultaneously determine dopamine (DA) and uric acid (UA). The LBL assembled electrode showed excellent electrocatalytic activity towards the oxidation of DA and UA. In addition, the self-assembly electrode possessed an excellent sensing performance for detection of DA and UA with a linear range from 0.1 μM to 140 µM and from 1.0 µM to 125 µM with the detection limit as low as 0.05 µM and 0.1 µM based on S/N=3, respectively.
authors.affiliation: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, PR China. Electronic address: xuexian@zjnu.cn.
authors.forename: Xuexiang
authors.initials: X
authors.lastname: Weng
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Cao
authors.forename: Lixin
authors.initials: L
authors.lastname: Liang
authors.forename: Jianrong
authors.initials: J
authors.lastname: Chen
authors.forename: Chunping
authors.initials: C
authors.lastname: You
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Ruan
authors.forename: Hongjun
authors.initials: H
authors.lastname: Lin
authors.forename: Lanju
authors.initials: L
authors.lastname: Wu
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D012996:Solutions; D014527:Uric Acid / Q000032:analysis*
chemical_list: D012996:Solutions; D014527:Uric Acid; D006108:Graphite; D048271:Chitosan; D001205:Ascorbic Acid; D004298:Dopamine
keywords: Chitosan; Dopamine; Graphene; Layer-by-layer; Uric acid