title: IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.
abstract: Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The University of Tokyo, Tokyo, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Nakanishi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Maho
authors.initials: M
authors.lastname: Suzukawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Shibui
authors.forename: Aya
authors.initials: A
authors.lastname: Nambu
authors.forename: Kenji
authors.initials: K
authors.lastname: Kondo
authors.forename: Hajime
authors.initials: H
authors.lastname: Suto
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tatuya
authors.initials: T
authors.lastname: Yamasoba
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakae
mesh_terms: D000818:Animals; D039741:Antigens, Dermatophagoides / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D020381:Interleukin-17 / Q000378:metabolism*; D000067596:Interleukin-33; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D051379:Mice; D039981:Pyroglyphidae / Q000276:immunology; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology* / Q000276:immunology / Q000378:metabolism*
chemical_list: D039741:Antigens, Dermatophagoides; C506536:IL33 protein, human; D020381:Interleukin-17; D000067596:Interleukin-33; D007378:Interleukins