title: Collective cell migration: a mechanistic perspective.
abstract: Collective cell migration is fundamental to gaining insights into various important biological processes such as wound healing and cancer metastasis. In particular, recent in vitro studies and in silico simulations suggest that mechanics can explain the social behavior of multicellular clusters to a large extent with minimal knowledge of various cellular signaling pathways. These results suggest that a mechanistic perspective is necessary for a comprehensive and holistic understanding of collective cell migration, and this review aims to provide a broad overview of such a perspective.
authors.affiliation: 1Mechanobiology Institute, National University of Singapore, Singapore;
authors.forename: Sri Ram Krishna
authors.initials: SR
authors.lastname: Vedula
authors.forename: Andrea
authors.initials: A
authors.lastname: Ravasio
authors.forename: Chwee Teck
authors.initials: CT
authors.lastname: Lim
authors.forename: Benoit
authors.initials: B
authors.lastname: Ladoux
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D015398:Signal Transduction; D049490:Systems Biology; D014945:Wound Healing