title: Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers.
abstract: The aim of this study was to evaluate the outcome of risk-reducing mastectomy in BRCA1/2 mutation carriers with and without breast cancer. Uptake, methods of operation and reconstruction, complications, patient satisfaction and histopathological findings were registered at all five departments of genetics in Norway. Data from 267 affected and unaffected BRCA1/2 mutation carriers were analyzed, including a study-specific questionnaire returned by 178 mutation carriers. There was a steady increase in the uptake of risk-reducing mastectomies during the study period. Complications were observed in 106/266 (39.7%) women. Patient satisfaction was high. The majority of women expressed great relief after risk-reducing mastectomy and would have chosen the same option again.
authors.affiliation: Department of Breast and Endocrine Surgery, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: anne.i.hagen@ntnu.no.
authors.forename: Anne Irene
authors.initials: AI
authors.lastname: Hagen
authors.affiliation: Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
authors.forename: Lovise
authors.initials: L
authors.lastname: Mæhle
authors.affiliation: Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
authors.forename: Nina
authors.initials: N
authors.lastname: Vedå
authors.affiliation: Western Norway Familial Cancer Center, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
authors.forename: Hildegunn Høberg
authors.initials: HH
authors.lastname: Vetti
authors.affiliation: Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
authors.forename: Astrid
authors.initials: A
authors.lastname: Stormorken
authors.affiliation: Department of Pathology and Medical Genetics, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Trond
authors.initials: T
authors.lastname: Ludvigsen
authors.affiliation: Department of Medical Genetics, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Bente
authors.initials: B
authors.lastname: Guntvedt
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Teres Stokkan, Teres Medical Group, Trondheim, Norway.
authors.forename: Anne Elisabeth
authors.initials: AE
authors.lastname: Isern
authors.affiliation: Department of Breast and Endocrine Surgery, Oslo University Hospital, Oslo, Norway.
authors.forename: Ellen
authors.initials: E
authors.lastname: Schlichting
authors.affiliation: Department of Breast and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway.
authors.forename: Geir
authors.initials: G
authors.lastname: Kleppe
authors.affiliation: Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Anna
authors.initials: A
authors.lastname: Bofin
authors.affiliation: Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.
authors.forename: Hans Petter
authors.initials: HP
authors.lastname: Gullestad
authors.affiliation: Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Møller
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006579:Heterozygote; D006801:Humans; D016462:Mammaplasty / Q000523:psychology; D008408:Mastectomy / Q000523:psychology; D008875:Middle Aged; D009664:Norway; D017060:Patient Satisfaction; D012189:Retrospective Studies
keywords: BRCA1; BRCA2; DIEP; Reconstruction; Risk-reducing mastectomy; SGAP; TRAM; deep inferior epigastric perforator flap; superior gluteal artery perforator flap; transverse rectus abdominal myocutaneous flap