title: [A case of recurrent breast cancer with liver metastases showing good response to combination therapy with S-1 plus trastuzumab].
abstract: Here, we report the case of a patient with recurrent breast cancer and multiple liver metastases who showed complete remission (CR) after S-1 plus trastuzumab therapy. A 54-year-old woman with stage IIIA left breast cancer received 4 courses of epirubicin hydrochloride plus cyclophosphamide hydrate therapy and 4 courses of paclitaxel therapy as initial treatment after mastectomy. At 10 months after surgery, the carcinoembryonic antigen (CEA) level increased to 79.0 ng/mL, and multiple liver metastases were detected on close examination. Subsequently, the patient received S-1 plus trastuzumab combination therapy. The CEA level returned to normal after 2 courses of the combination therapy, and the liver metastases disappeared after 5 courses of therapy. CR has been maintained for 1 year and 3 months after the initiation of treatment. Because the present treatment has superior tolerability and safety, it is considered an effective option for treating recurrent breast cancer.
authors.affiliation: Dept. of Surgery, Seto Inland Sea Hospital.
authors.forename: Kazuitsu
authors.initials: K
authors.lastname: Ishida
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008408:Mastectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D012008:Recurrence; D005641:Tegafur / Q000008:administration & dosage; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000068878:Trastuzumab