title: [Encephalitis due to the Epstein-Barr virus: a description of a clinical case and review of the literature].
abstract: INTRODUCTION. Infection by the Epstein-Barr virus (EBV) -either as a primary infection, a reactivation or an active chronic infection- can give rise to several clinical forms of involvement of the central nervous system. We report a case of encephalitis due to EBV produced by viral reactivation in an immunocompetent patient which initially mimicked, from the clinical and electroencephalographic point of view, encephalitis due to type 1 herpes simplex virus (HSV-1). CASE REPORT. A 51-year-old male who had reported the presence of dorsal herpes zoster some days earlier. The patient visited the emergency department after suffering a holocranial oppressive headache and febricula for seven days; 24 hours before admission to hospital, he was suffering from drowsiness and language disorder. The neurological examination revealed stiffness in the back of the neck and dysphasia. An analysis of the cerebrospinal fluid revealed pleocytosis (422 cells/mm(3)) with 98% of mononuclear cells and normal protein and glucose concentration levels in cerebrospinal fluid. Magnetic resonance imaging of the brain and electroencephalogram readings were normal with periodic lateralised epileptiform discharges in the left temporal region. Intravenous acyclovir treatment was initiated, but renal failure meant it had to be changed to oral valaciclovir with clinical resolution and improvement of the liquoral parameters. Polymerase chain reaction in the cerebrospinal fluid was positive for EBV and negative for the other neurotropic viruses. In blood, the serology test for EBV with IgG was positive, while IgM and heterophile antibody tests were negative. CONCLUSIONS. EBV infection can give rise to acute disseminated encephalomyelitis or affect several locations in the central nervous system, especially the cerebellum. Clinical pictures mimicking HSV-1 are less frequent. When encephalitis is related to viral reactivation, precipitating factors can be detected, as in our case.
authors.affiliation: Hospital Clinico Universitario de Valladolid, 47005 Valladolid, Espana.
authors.forename: Johanna
authors.initials: J
authors.lastname: Barón
authors.forename: Sonia
authors.initials: S
authors.lastname: Herrero-Velázquez
authors.forename: Marina
authors.initials: M
authors.lastname: Ruiz-Piñero
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Pedraza
authors.forename: Silvia
authors.initials: S
authors.lastname: Rojo-Rello
authors.forename: Ángel Luis
authors.initials: ÁL
authors.lastname: Guerrero-Peral
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000212:Acyclovir / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology; D057915:Drug Substitution; D004569:Electroencephalography; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D004827:Epilepsy / Q000209:etiology; D020031:Epstein-Barr Virus Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D006562:Herpes Zoster / Q000150:complications; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir