title: Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection.
abstract: Neuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca(2+)]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets.
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Santos-Carvalho
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Department of Biology and Environment, University of Trás-os-Montes and Alto Douro, Apartado 1013, 5001-801 Vila Real, Portugal.
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Álvaro
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Martins
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal; AIBILI-Association for Innovation and Biomedical Research on Light and Image, Azinhaga Santa Comba, Celas, 3000-548 Coimbra, Portugal.
authors.forename: António Francisco
authors.initials: AF
authors.lastname: Ambrósio
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address: ccavadas@uc.pt.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Cavadas
mesh_terms: D000818:Animals; D006801:Humans; D009478:Neuropeptide Y / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017476:Receptors, Neuropeptide Y / Q000378:metabolism*; D055351:Retinal Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D017476:Receptors, Neuropeptide Y
keywords: 3,4-methylenedioxymethamphetamine; 5-bromo-2′-deoxyuridine; BrdU; CNS; DPP-IV; E18; ERK; GABA; GABA transporter 1; GAD 65; GAT-1; GCL; INL; IPL; Leu; MAPK; MDMA; NO; NOS–sGC; NPY; NPY Y(1); NPY receptor type 1; NPY receptors; NPY–IR; Neuromodulation; Neuropeptide Y; Neuroprotection; ONL; OPL; P7; PKA; POS; Pro; RPE; Retina; Retinal neural cells; [Ca(2+)](i); central nervous system; dipeptidyl peptidase IV; embrionic day 18; extracellular signal-regulated kinases; ganglion cell layer; glutamic acid decarboxylase 65; hESC; human embryonic stem cells; iGluRs; inner nuclear layer; inner plexiform layer; intracellular calcium; ionotropic glutamate receptors; leucine; mGLuRs; mRNA; messenger ribonucleic acid; metabotropic glutamate receptors; mitogen activated protein kinase; neuropeptide Y; neuropeptide Y immunoreactivity; nitric oxide; nitric oxide synthase – soluble guanylyl cyclase; outer nuclear layer; outer plexiform layer; photoreceptor outer segment; postnatal day 7; proline; protein kinase A; retinal pigmented epithelium; γ-aminobutyric acid