title: Ru(II)-catalyzed vinylative dearomatization of naphthols via a C(sp2)-H bond activation approach.
abstract: Intermolecular annulation reactions of 1-aryl-2-naphthols with internal alkynes proceed efficiently in the presence of a Ru catalyst and a Cu oxidant to generate spirocyclic compounds by sequential cleavage of the C(sp(2))-H bond, migratory insertion of the alkyne, and dearomatization of the naphthyl ring. Various spirocyclic molecules bearing an all-carbon quaternary stereocenter could be obtained by this novel method with good yields and excellent regioselectivity, and the current process tolerates a variety of synthetically important functional groups.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University , Xi'an 710069, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Nan
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zuo
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.forename: Huayu
authors.initials: H
authors.lastname: Zheng
authors.forename: Yini
authors.initials: Y
authors.lastname: Yuan
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Xinjun
authors.initials: X
authors.lastname: Luan
authors.forename: Yaoyu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D009284:Naphthols; D013141:Spiro Compounds; D012428:Ruthenium