title: Cellular neurothekeoma of the eyelid: a unique internal palpebral presentation.
abstract: A 50-year-old woman presented with a mass lesion of the inferolateral palpebral conjunctiva similar in appearance to a chalazion, but unusual enough in presentation that excisional biopsy was initially performed. Histopathologic analysis revealed a dermal fibrohistiocytic neoplasm consistent with cellular neurothekeoma. Neurothekeoma is a benign tumor; the cellular variant is rare and of unclear histogenesis. Completely internal eyelid location is particularly rare, with other identifiable case reports of cellular neurothekeoma palpebrae referring to external or unspecified eyelid location. This case provides an example of the chalazion as masquerader and re-emphasizes the importance of maintaining a broad differential diagnosis and high index of suspicion regarding atypically appearing chalazia.
authors.affiliation: *Division of Ophthalmic Plastic Surgery, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; †Division of Ophthalmology and ‡Department of Dermatology, Division of Dermatopathology, Rhode Island Hospital, The Warren Alpert Medical School at Brown University, Providence, Rhode Island, U.S.A.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Lefebvre
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
authors.forename: Michael E
authors.initials: ME
authors.lastname: Migliori
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D003228:Conjunctiva / Q000473:pathology*; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D018321:Neurothekeoma / Q000175:diagnosis* / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor