title: Disrupted default mode network connectivity in migraine without aura.
abstract: BACKGROUND
  Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine without aura (MwoA) and investigate its clinical significance.
  
  
  METHODS
  To calculate and compare the resting-state functional connectivity of the DMN in 20 patients with MwoA, during the interictal period, and 20 gender- and age-matched HC, Brain Voyager QX was used. Voxel-based morphometry was used to assess whether between-group differences in DMN functional connectivity were related to structural differences. Secondary analyses explored associations between DMN functional connectivity, clinical and neuropsychological features of migraineurs.
  
  
  RESULTS
  In comparison to HC, patients with MwoA showed decreased connectivity in prefrontal and temporal regions of the DMN. Functional abnormalities were unrelated to detectable structural abnormalities or clinical and neuropsychological features of migraineurs.
  
  
  CONCLUSIONS
  Our study provides further evidence of disrupted DMN connectivity in patients with MwoA. We hypothesize that a DMN dysfunction may be related to behavioural processes such as a maladaptive response to stress which seems to characterize patients with migraine.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tessitore
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giordano
authors.forename: Francesca
authors.initials: F
authors.lastname: Conte
authors.forename: Daniele
authors.initials: D
authors.lastname: Corbo
authors.forename: Manuela
authors.initials: M
authors.lastname: De Stefano
authors.forename: Sossio
authors.initials: S
authors.lastname: Cirillo
authors.forename: Mario
authors.initials: M
authors.lastname: Cirillo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Esposito
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology* / Q000523:psychology; D009415:Nerve Net / Q000503:physiopathology*