title: Pyrethroid insecticide exposure and semen quality of young Japanese men.
abstract: The present study aimed at assessing the relationship between exposure to pyrethroid insecticides and semen quality in 323 university students recruited in a population-based manner in Metropolitan Tokyo. Urinary concentrations of pyrethroid insecticide metabolite, 3-phenoxybenzoic acid (3-PBA), were measured by LC/MS/MS and semen parameters were measured by following internationally harmonized protocols. Median urinary 3-PBA concentration was 0.641 ng/mL (specific gravity-adjusted, n=322). Median values of semen volume, sperm concentration, motility, total number of sperm, and total number of motile sperm were 2.5 mL, 56×10(6)/mL, 61%, 141×10(6), and 82×10(6), respectively. Urinary concentration of 3-PBA was not selected as significant in multiple regression models indicating, in contrast to previous findings, that environmental exposure to pyrethroid insecticides did not affect semen quality. This inconsistency may be related to exposure to different pyrethroid insecticides and/or levels of exposure as well as to survey design (hospital- vs population-based subject recruitment).
authors.affiliation: Department of Environmental Studies, University of Tokyo, Kashiwa, Chiba 277-8563, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Imai
authors.affiliation: Department of Environmental Studies, University of Tokyo, Kashiwa, Chiba 277-8563, Japan. Electronic address: junyosh@k.u-tokyo.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshinaga
authors.affiliation: Department of Environmental Studies, University of Tokyo, Kashiwa, Chiba 277-8563, Japan.
authors.forename: Mitsuha
authors.initials: M
authors.lastname: Yoshikane
authors.affiliation: National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8563, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shiraishi
authors.affiliation: Centre for Information, Jichi Medical University, Shimotsuke, Tchigi 329-0498, Japan.
authors.forename: Makiko Naka
authors.initials: MN
authors.lastname: Mieno
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Yoshiike
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan.
authors.forename: Shiari
authors.initials: S
authors.lastname: Nozawa
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan; Center for Infertility and IVF, International University of Health and Welfare Hospital, Nasushiobara, Tochigi 329-2763, Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Iwamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D001565:Benzoates / Q000652:urine*; D004784:Environmental Monitoring; D006801:Humans; D007306:Insecticides / Q000652:urine*; D008297:Male; D009929:Organ Size; D055101:Semen Analysis; D013737:Testis / Q000033:anatomy & histology; D055815:Young Adult
chemical_list: D001565:Benzoates; D007306:Insecticides; C017618:3-phenoxybenzoic acid
keywords: Multiple regression analysis; Pyrethroid insecticide; Semen quality; University student; Urinary 3-PBA