title: Rifampicin-induced acute kidney injury during the initial treatment for pulmonary tuberculosis: a case report and literature review.
abstract: A 47-year-old man diagnosed with pulmonary tuberculosis was referred to our hospital. Rifampicin, isoniazid, pyrazinamide and ethambutol were administered, and the patient's symptoms promptly improved. On the 19th hospital day, he developed acute kidney injury with a fever and chills. Renal biopsy specimens indicated tubulointerstitial nephritis. Suspecting rifampicin-induced acute kidney injury, we discontinued the rifampicin and administered levofloxacin in its place. The patient's serum creatinine level subsequently gradually improved. We herein report this case and review eight cases reported in Japan. We found that the rifampicin toxicity appeared at both the initial administration and readministration. All eight patients presented with proteinuria.
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: Sahoko
authors.initials: S
authors.lastname: Chiba
authors.forename: Kimitake
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakashita
authors.forename: Eisaku
authors.initials: E
authors.lastname: Ito
authors.forename: Naohiko
authors.initials: N
authors.lastname: Inase
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000473:pathology; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D003404:Creatinine; D012293:Rifampin