title: Combined inhibition of Na⁺ and Ca²⁺ channels: a novel paradigm for the treatment of incessant ventricular arrhythmias in Andersen-Tawil syndrome.
authors.affiliation: Division of Cardiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: jansonc@email.chop.edu.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Janson
authors.affiliation: Center for Heart and Regenerative Biology, Virginia Tech Carilion Research Institute and School of Biomedical Engineering and Sciences, Virginia Tech University, Blacksburg, Virginia.
authors.forename: Steven
authors.initials: S
authors.lastname: Poelzing
authors.affiliation: Division of Cardiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Maully J
authors.initials: MJ
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D050030:Andersen Syndrome / Q000150:complications*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D015716:Electrocardiography, Ambulatory; D005424:Flecainide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D026941:Sodium Channel Blockers / Q000627:therapeutic use*; D018879:Ventricular Premature Complexes / Q000188:drug therapy / Q000209:etiology; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D026941:Sodium Channel Blockers; D014700:Verapamil; D005424:Flecainide
keywords: ATS1; Andersen-Tawil syndrome type 1; Calcium-mediated arrhythmia; DAD; IQR; RyR; Sodium channel blockade; VT; Ventricular tachycardia; delayed afterdepolarization; interquartile range; ryanodine receptor; ventricular tachycardia