title: [Vitamin D level in Hungarian patients with inflammatory bowel diseases].
abstract: BACKGROUND
  Vitamin D has an important role in the immune regulation. Vitamin D is essential for innate and adaptive immune systems and it plays a significant role in the formation of immune tolerance, as well.
  
  
  OBJECTIVE
  Vitamin D deficiency has been observed in patients with inflammatory bowel diseases in Western Europe, but there is no data available from Eastern Europe.
  
  
  METHODS
  The study included 169 patients with inflammatory bowel disease.
  
  
  RESULTS
  The median vitamin D level was 22.7±10.6 ng/ml. Only 20% of the patients had adequate vitamin D level (>30 ng/ml), 52% had vitamin D insufficiency (15-30 ng/ml), and 28% of them had severe vitamin D deficiency (<15 ng/ml). Vitamin D concentration failed to correlate with clinical activity indexes (partial Mayo score: r = -0.143; Crohn's disease activity index: r = -0.253) and with inflammatory parameters (C-reactive protein: r = 0.008; erythrocyte sedimentation rate: r = 0.012).
  
  
  CONCLUSIONS
  Since vitamin D deficiency can be frequently observed in Hungarian patients with inflammatory bowel disease, its level should be tested in these patients.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088.
authors.forename: Katalin
authors.initials: K
authors.lastname: Lőrinczy
authors.forename: Péter László
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Miklós
authors.initials: M
authors.lastname: Tóth
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Salamon
authors.forename: Adrienn
authors.initials: A
authors.lastname: Nemes
authors.forename: Ágnes Anna
authors.initials: ÁA
authors.lastname: Csontos
authors.forename: Bálint
authors.initials: B
authors.lastname: Fekete
authors.forename: Orsolya
authors.initials: O
authors.lastname: Terjék
authors.forename: László
authors.initials: L
authors.lastname: Herszényi
authors.forename: Márk
authors.initials: M
authors.lastname: Juhász
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
authors.forename: Pál
authors.initials: P
authors.lastname: Miheller
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000097:blood / Q000150:complications; D003424:Crohn Disease / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014807:Vitamin D / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D014815:Vitamins / Q000097:blood* / Q000276:immunology / Q000378:metabolism
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002097:C-Reactive Protein
keywords: Crohn-betegség; Crohn’s disease; D-vitamin; colitis ulcerosa; gyulladásos bélbetegség; inflammatory bowel diseases; ulcerative colitis; vitamin D