title: [Acquired hypertriglyceridemia].
abstract: Hypertriglyceridemia is associated with an increase in very low density lipoprotein (VLDL), chylomicron, intermediate density lipoprotein(IDL). Acquired hyperlipidemia results from various disorders, such as obesity, diabetes mellitus, alcohol overuse, chronic kidney disease, hypothyroidism, and some drugs like thiazide, -blocker, estrogen, etc. It is important to identify secondary causes underlying hypertriglyceridemia before initiating pharmacotherapy, since management of the causative disorders is the first-line therapy. Even if hyperlipidemia is not controlled after treating the underlying disorders, specific lipid -lowering therapy may be required in addition to lifestyle modification. Fibrate, nicotinic acid and eicosapentaenoic acid are utilized to reduce triglyceride levels. Statin and ezetimibe are utilized if non-high density lipoprotein(HDL)-cholesterol is elevated.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University.
authors.forename: Manabu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
mesh_terms: D000437:Alcoholism / Q000150:complications; D048909:Diabetes Complications / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D007674:Kidney Diseases / Q000150:complications; D008074:Lipoproteins / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides