title: Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths.
abstract: OBJECTIVE
  To evaluate whether serum resistin levels are related to cardiovascular risk in obese children.
  
  
  METHODS
  Cross-sectional study of 110 children (40 normal weight and 70 severely obese). Clinical and biochemical parameters, including lipid profile, fasting glucose and insulin, and homocysteine, were determined. The levels of adipokines (adiponectin, leptin, and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP)), endothelial activation (serum concentrations of soluble intercellular and vascular cellular adhesion molecule-1 (sICAM-1, sVCAM-1)), and oxidative/nitrosative stress (malondialdehyde and urinary nitrate/nitrite) were measured.
  
  
  RESULTS
  A partial correlation adjusted by gender, Tanner stage, and body mass index in obese children showed that resistin was significantly related to central obesity (p<0.002), insulin resistance (p<0.005), and homocysteine (p<0.001). No association was found with other metabolic risk factors or hs-CRP levels. Malondialdehyde (p<0.043) and sVCAM-1 (p<0.002) were positively correlated whereas urinary nitrate/nitrite was negatively correlated (p<0.007). In multiple regression analysis homocysteine, sVCAM-1, and urinary nitrate/nitrite remained independent determinants of resistin levels (R(2) adjusted=0.347, p=0.000).
  
  
  CONCLUSIONS
  Resistin could be considered as a promising marker for future cardiovascular disease in obese children.
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital, 46017 Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain. Electronic address: pilar.codoner@uv.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Codoñer-Franch
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Tavárez-Alonso
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital, 46017 Valencia, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Porcar-Almela
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital, 46017 Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Navarro-Solera
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital, 46017 Valencia, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Arilla-Codoñer
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain.
authors.forename: Eulalia
authors.initials: E
authors.lastname: Alonso-Iglesias
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D015538:Nitrosation; D009765:Obesity / Q000097:blood*; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: D052243:Resistin; D006710:Homocysteine
keywords: Cardiovascular risk; Children; Endothelial dysfunction; Homocysteine; Nitric oxide; Obesity; Resistin