title: Colorimetric sensor based on dual-functional gold nanoparticles: analyte-recognition and peroxidase-like activity.
abstract: A novel colorimetric sensor based on the interaction ability with specific analytes and peroxidase-like activity of gold nanoparticles was established in this work. Combining the high-affinity binding between bare gold nanoparticles and melamine with signal amplification procedure based on the catalytic activity of gold nanoparticles for oxidation of TMB, melamine with the concentration as low as 0.02 mg/L can be easily distinguished by naked-eye observation. Such system can be adapted through carefully-controlled surface modifications of gold nanoparticles for determination of other targets.
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004, China.
authors.forename: Hao-Hua
authors.initials: HH
authors.lastname: Deng
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Hong
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lin
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Xia
mesh_terms: D003124:Colorimetry / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D041943:Infant Formula / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D009195:Peroxidase / Q000737:chemistry*; D014227:Triazines / Q000032:analysis*
chemical_list: D014227:Triazines; D006046:Gold; D009195:Peroxidase; C011907:melamine
keywords: Colorimetric sensor; Enzyme mimics; Gold nanoparticles; Infant formula; Melamine; Signal amplification