title: Usefulness of nano-zirconia for purification and concentration of ¹²⁵I solution for medical applications.
abstract: This paper described the utility of tetragonal nano-zirconia (t-ZrO₂) to remove trace levels of ¹³⁴Cs and ¹³⁷Cs contaminants from ¹²⁵I solution obtained from neutron irradiation of natural Xe target. A careful scrutiny of the adsorption parameters of t-ZrO₂ was considered worthwhile investigating to arrive at the optimum conditions to perform the purification as well as concentration of ¹²⁵I solution. The procedure proposed herein provides ¹²⁵I of acceptable purity and radioactive concentration for clinical application. The compatibility of the separated product in the preparation of ¹²⁵I brachytherapy sources was found to be satisfactory.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Ramu
authors.initials: R
authors.lastname: Ram
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
mesh_terms: D000327:Adsorption; D001918:Brachytherapy; D002588:Cesium Radioisotopes / Q000302:isolation & purification; D002853:Chromatography, Liquid; D004340:Drug Contamination; D006801:Humans; D007457:Iodine Radioisotopes / Q000302:isolation & purification* / Q000627:therapeutic use; D053768:Metal Nanoparticles; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000302:isolation & purification / Q000627:therapeutic use; D012996:Solutions; D014978:Xenon / Q000528:radiation effects; D015040:Zirconium
chemical_list: D002588:Cesium Radioisotopes; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D012996:Solutions; D014978:Xenon; D015040:Zirconium; C028541:zirconium oxide
keywords: Column chromatography; Iodine-125; Nano-zirconia; Radioactive concentration; Radionuclidic purity