title: Clinical controversies in vitamin D: 25(OH)D measurement, target concentration, and supplementation.
abstract: Despite a plethora of recent research and systematic reviews of available data, controversy continues to surround the definition of optimal vitamin D status, the daily intake needed, and the potential adverse health consequences of "insufficiency." Efforts to standardize vitamin D measurement and improve understanding of the physiologic consequences of other vitamin D metabolites such as 3-epi and 24,25(OH)2D (and potentially other vitamin D compounds) are needed. Currently, measurement of circulating 25(OH)D is accepted as the approach to define an individual's vitamin D status. However, existing 25(OH)D assays may include other vitamin D metabolites such as the 3-epimer of 25(OH)D and 24,25(OH)2D. It seems unlikely that the controversy will soon be resolved.
authors.affiliation: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: nbinkley@wisc.edu.
authors.forename: Neil
authors.initials: N
authors.lastname: Binkley
authors.forename: Donald
authors.initials: D
authors.lastname: Wiebe
mesh_terms: D050071:Bone Density Conservation Agents / Q000493:pharmacokinetics; D019587:Dietary Supplements; D006801:Humans; D010024:Osteoporosis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D014807:Vitamin D / Q000493:pharmacokinetics*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000628:therapy*
chemical_list: D050071:Bone Density Conservation Agents; D014807:Vitamin D
keywords: 25-Hydroxyvitamin D; measurement; supplementation; vitamin D