title: Pneumothorax developing for the first time in a 73-year-old woman diagnosed with Birt-Hogg-Dubé syndrome.
abstract: Spontaneous pneumothorax in the elderly commonly occurs due to underlying pulmonary diseases, such as chronic obstructive pulmonary disease, interstitial lung disease, lung cancer, etc. A 73-year-old woman developed pneumothorax for the first time that was a clinical clue to a diagnosis of Birt-Hogg-Dubé syndrome (BHDS), an autosomal dominant condition characterized by fibrofolliculomas of the skin, renal tumors and multiple lung cysts predisposing to pneumothorax. Although BHDS patients frequently develop pneumothorax during their twenties to forties, the present case indicates that BHDS should be considered as an underlying cause of pneumothorax in the elderly with undisclosed BHDS.
authors.affiliation: Division of Respiratory Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Kunogi Okura
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yae
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagashima
authors.forename: Shu
authors.initials: S
authors.lastname: Hirai
authors.forename: Toshio
authors.initials: T
authors.lastname: Kumasaka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Iwase
mesh_terms: D000368:Aged; D058249:Birt-Hogg-Dube Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D010641:Phenotype; D011030:Pneumothorax / Q000209:etiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C476078:FLCN protein, human; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins