title: [Current concepts of weaning children from invasive ventilation].
abstract: Timely weaning from invasive ventilation is of major importance to limit time of invasive ventilation and improve outcomes. However, in pediatrics only limited knowledge on the optimal weaning approach is available. In this review evidence from recent trials on weaning in pediatrics is summarized. Standardized daily evaluation of weaning readiness, daily interruption of sedation, use of pediatric sedation protocols, application of noninvasive ventilation and prophylactic treatment with steroids of patients with high risk for post-extubation upper airway obstruction have been shown to decrease duration of invasive ventilation or to decrease the risk of extubation failure. However, due to the heterogeneous patient population in pediatric intensive care units, an individual approach might be necessary for certain subgroups of pediatric patients.
authors.forename: Hans
authors.initials: H
authors.lastname: Fuchs
authors.forename: Thomas
authors.initials: T
authors.lastname: Nicolai
authors.forename: Manuel B
authors.initials: MB
authors.lastname: Schmid
authors.forename: Marcus
authors.initials: M
authors.lastname: Krüger
mesh_terms: D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D003422:Critical Care / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010372:Pediatrics / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000517:prevention & control*; D018570:Risk Assessment; D015300:Ventilator Weaning / Q000009:adverse effects* / Q000379:methods*