title: [Studies on evaluation of sustained release tablets of extracts of Ginkgo biloba releasing rate in vitro by pharmacological indicatrix].
abstract: Using sustained release tablets of Ginkgo bibolia extract as model drug,discuss technical feasibility of using biotic index to evaluate sustained release tablets. Chosing two pharmacological indicatrix: antioxidant ability and inhibition of platelet aggregation, to investigate the influence factors on experimental result, optimize the method and experiment condition, and set up pharmacological indicatrix evaluation method. Using those methods to determinate biological effects of dissolved liquid. Drawing release curves and biological effects curves, discussing their correlation. A good correlation was observed, illustrating that pharmacological indicatrix could evaluate sustained release tablets.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. dpplih@126.com
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Du
authors.forename: Bo-Chen
authors.initials: BC
authors.lastname: Zhao
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000737:chemistry; D011817:Rabbits; D013607:Tablets
chemical_list: D000975:Antioxidants; D003692:Delayed-Action Preparations; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013607:Tablets