title: [Preparation and evaluation of valerian oil-beta-cyclodextrin inclusion complex].
abstract: The aim of this study was to improve the stability and cover the unpleasant odor of valerian oil by preparation of beta-cyclodextrin inclusion complex. The preparation method was established based on the yield of inclusion complex and entrapment efficiency of valerian volatile oil. After that, the formulation and processing parameters were optimized by uniform design table. The formations of inclusion complex were validated by DSC and X-RD method. The stability of valerian oil beta-cyclodextrin inclusion was studied under stressed conditions. In conclusion, relatively high yield of inclusion complex and entrapment efficiency were obtained by saturated solution-ultrasonication method. Inclusion complex yield and entrapment efficiency of the valerian oil were (84.78 +/- 3.23)% and (86.23 +/- 2.48)%, which were prepared under the optimized conditions, respectively. The results of DSC and X-RD were indicated the formation of inclusion complex. The stability of test showed that the valerian oil-beta-cyclodextrin inclusion complex was improved significantly.
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. si.qi47@yahoo.com.cn
authors.forename: Qi
authors.initials: Q
authors.lastname: Si
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Qing-Ri
authors.initials: QR
authors.lastname: Cao
authors.forename: Jing-Hao
authors.initials: JH
authors.lastname: Cui
mesh_terms: D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009812:Odorants; D009822:Oils, Volatile / Q000737:chemistry*; D014632:Valerian / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins