title: Effect of the phosphonic analogue of tyrosine on tyrosine iodination.
abstract: Depositing ofDL-1-amino-2-(p-hydroxyphenyl)-ethylphosphonic acid (Tyr-P) on the chicken embryo induced a dose dependent decrease of the iodine uptake by the embryonic thyroid. Tyr-P interfered on iodination of tyrosine when tested with hog thyroid peroxidase (TPO) and with bovine lactoperoxidase (LPO); the analogue was recognized by the two enzymes but its affinity for TPO and LPO was respectively 3 and 7 fold higher compared with that of the natural substrate, suggesting that Tyr-P may act as an iodine trap.
authors.affiliation: Département de Biochimie Médicale et Biologie Moléculaire, Université de Bordeaux 2, 146, rue Léo-Saignat, F-33076, Bordeaux Cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Iron
authors.forename: E
authors.initials: E
authors.lastname: Neuzil
authors.forename: A
authors.initials: A
authors.lastname: Cassaigne