title: Comparison of diffuse optical tomography, ultrasound elastography and mammography in the diagnosis of breast tumors.
abstract: Previous studies have reported the usefulness of diffuse optical tomography (DOT), ultrasound elastography (UE) and mammography in differentiating breast tumors. This study was aimed at evaluating and comparing DOT, UE and mammography with respect to their diagnostic performance in differentiating benign and malignant breast tumors. Of the 67 tumors, 45 were histopathologically benign, and 22 were malignant. UE was the most specific (93.33%) of the three diagnostics modalities. DOT and UE were both more accurate (80.60% and 89.55%, respectively) than mammography (63.08%). UE + mammography (93.33% and 91.04%) and DOT + mammography (77.78% and 82.09%) exhibited higher specificity and accuracy, respectively, than mammography alone (57.78% and 63.08%). Receiver operating characteristic (ROC) curves were constructed to assess the performance of the modalities. In conclusion, UE and DOT were superior to conventional mammography in terms of both specificity and accuracy. DOT and UE improve the specificity and accuracy of breast cancer diagnosis, and combining the two modalities improves the diagnostic value.
authors.affiliation: Department of Ultrasonography, Binzhou Medical University Hospital, Binzhou, Shandong Province, China.
authors.forename: Haixian
authors.initials: H
authors.lastname: Zhang
authors.forename: Dongjing
authors.initials: D
authors.lastname: Qin
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
authors.forename: Baowei
authors.initials: B
authors.lastname: Li
authors.forename: Guanghe
authors.initials: G
authors.lastname: Cui
mesh_terms: D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*; D055815:Young Adult
keywords: Breast tumor; Diffuse optical tomography; Mammography; Ultrasound elastography