title: Selecting magnetic resonance imaging (MRI) outcome measures for juvenile idiopathic arthritis (JIA) clinical trials: first report of the MRI in JIA special interest group.
abstract: Recent advances in magnetic resonance imaging (MRI) techniques have substantially improved the evaluation of joint pathologies in juvenile idiopathic arthritis (JIA). Because of the current availability of highly effective antirheumatic therapies and the unique and useful features of MRI, there is a growing need for an accurate and reproducible MRI assessment scoring system for JIA, such as the rheumatoid arthritis MRI Scoring (RAMRIS) for patients with rheumatoid arthritis (RA). To effectively evaluate the efficacy of treatment in clinical research trials, we need to develop and validate scoring methods to accurately measure joint outcomes, standardize imaging protocols for data acquisition and interpretation, and create imaging atlases to differentiate physiologic and pathologic joint findings in childhood and adolescence. Such a standardized, validated, JIA-MRI scoring method could be used as an outcome measure in clinical trials.
authors.affiliation: From the Department of Radiology, Academic Medical Center, University of Amsterdam; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Diagnostic Imaging, the Hospital for Sick Children, Toronto, Ontario Canada; Department of Pediatric Rheumatology, Center for Rheumatic Diseases, Bad Bramstedt, Germany; Department of Rheumatology, Leiden University Medical Center, Leiden; Department of Pediatric Rheumatology, Amsterdam, the Netherlands.
authors.forename: Robert
authors.initials: R
authors.lastname: Hemke
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Doria
authors.forename: Nikolay
authors.initials: N
authors.lastname: Tzaribachev
authors.forename: Mario
authors.initials: M
authors.lastname: Maas
authors.forename: Désirée M F M
authors.initials: DM
authors.lastname: van der Heijde
authors.forename: Marion A J
authors.initials: MA
authors.lastname: van Rossum
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000473:pathology*; D002986:Clinical Trials as Topic; D006801:Humans; D007596:Joints / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017063:Outcome Assessment, Health Care; D013585:Synovitis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D018501:Antirheumatic Agents
keywords: CHILDREN; GUIDELINES; JUVENILE IDIOPATHIC ARTHRITIS; MAGNETIC RESONANCE IMAGING; SCORING SYSTEMS