title: Olfactory dysfunction in patients with neuromyelitis optica.
abstract: Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). Methods. Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. Results. Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. Conclusions. Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO.
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany ; Clinical and Experimental Multiple Sclerosis Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Schmidt
authors.forename: Onder
authors.initials: O
authors.lastname: Göktas
authors.forename: Sven
authors.initials: S
authors.lastname: Jarius
authors.forename: Brigitte
authors.initials: B
authors.lastname: Wildemann
authors.forename: Klemens
authors.initials: K
authors.lastname: Ruprecht
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
authors.forename: Lutz
authors.initials: L
authors.lastname: Harms