title: Signalling pathways linking integrins with cell cycle progression.
abstract: Integrins are adhesion receptors that allow cells to sense and respond to microenvironmental signals encoded by the extracellular matrix. They are crucial for the adhesion, survival, proliferation, differentiation and migration of most cell types. In cell cycle regulation, integrin-mediated signals from the local niche constitute a spatial checkpoint to allow cells to progress from G1 to S phase, and are as important as temporal growth factor signals. Proliferation is altered in diseases such as cancer and fibrosis, so understanding how integrins contribute to this process will provide novel strategies for therapy. Here we consider recent studies to elucidate mechanisms of integrin-dependent cell cycle progression and discuss perspectives for future study.
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Paulina
authors.initials: P
authors.lastname: Moreno-Layseca
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address: cstreuli@manchester.ac.uk.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Streuli
mesh_terms: D002448:Cell Adhesion / Q000235:genetics; D059447:Cell Cycle Checkpoints / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D005109:Extracellular Matrix / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D016023:Integrins
keywords: Adhesion complex; Akt; Cell cycle progression; ECM; Erk; Growth factor; Integrin; Proliferation; Rac