title: Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma.
abstract: OBJECTIVE
  This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.
  
  
  METHODS
  Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression.
  
  
  RESULTS
  Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p<0.001) and lower MSH2 immunohistochemical expressions (OR=2.943, p=0.032) presented poorer survival for HNSCC by Cox regression models.
  
  
  CONCLUSIONS
  Our data demonstrated that lower MSH2 expression might contribute to a higher clinic aggressiveness of HNSCC by promoting an unfavorable outcome.
authors.affiliation: Nucleus of Epidemiological and Molecular Research Catrumano, Health Research Laboratory, Health Science Post-Graduate Programme, Universidade Estadual de Montes Claros, Montes ClarosMG, Brazil.
authors.forename: Camila Santos
authors.initials: CS
authors.lastname: Pereira
authors.forename: Marcos Vinícius Macedo de
authors.initials: MV
authors.lastname: Oliveira
authors.forename: Lucas Oliveira
authors.initials: LO
authors.lastname: Barros
authors.forename: Gabriela Alencar
authors.initials: GA
authors.lastname: Bandeira
authors.forename: Sérgio Henrique Sousa
authors.initials: SH
authors.lastname: Santos
authors.forename: John R
authors.initials: JR
authors.lastname: Basile
authors.forename: André Luiz Sena
authors.initials: AL
authors.lastname: Guimarães
authors.forename: Alfredo Maurício Batista
authors.initials: AM
authors.lastname: De Paula
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004260:DNA Repair; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D051718:MutS Homolog 2 Protein