title: Chronic Constipation Caused by Neurofibromatous Proliferation in A Case of Von Recklinghausen's Disease - A Case Report.
abstract: Neurofibromatosis (NF) is an autosomal dominant genetic disorder with a myriad of clinical manifestations . A gastrointestinal involvement which is present in 10 -25% of patients, is usually a systemic manifestation of generalised NF. We are describing a case of NF 1 with chronic constipation, in whom colonoscopy revealed a thickening of the colon wall with narrowing. A mucosal biopsy showed neural hyperplasia .This case emphasizes the value of minimally invasive endoscopic biopsies of GI lesions in NF1, where despite a limited sampling, correlation with clinical and endoscopic features may help in reaching a diagnosis of a neurofibromatous proliferation. We have also discussed the differential diagnosis of gastrointestinal lesions in NF with neural hyperplasia.
authors.affiliation: Assistant Professor, Department of Pathology, M.S. Ramaiah Medical College , Bangalore, Karnataka, India .
authors.forename: Honnappa
authors.initials: H
authors.lastname: Sridhar
authors.forename: Rau
authors.initials: R
authors.lastname: R Aarathi
authors.forename: Mysorekar
authors.initials: M
authors.lastname: Vijaya
authors.forename: Jalihal
authors.initials: J
authors.lastname: Umesh
keywords: Constipation; GIT; Mucosal biopsy; Neural proliferation; Neurofibromatosis