title: The effects of different dosage levels of hepatitis B vaccine as booster on anti-HBs-negative children 5-15 y after primary immunization; China, 2009-2010.
abstract: The changes in lgG antibody levels to hepatitis B surface antigen (HBsAg) and in antibody to HBsAg (anti-HBs) seroconversion rates due to different dosages of hepatitis B vaccine (HepB) were compared in 2106 children. Children who had been previously vaccinated as infants with HepB were revaccinated at 5-15 y of age, after which the antibody titers were determined. After the first booster dose, the anti-HBs seroconversion rate (defined as an anti-HBs ≥10 mIU/ml) with 10 μg of HepB (93.6%) was significantly greater than the rate with 5 µg of HepB (90.3%) (P<0.05); the anti-HBs seroconversion rate in 10-15-y-old boys vaccinated with 10 μg of HepB (90.9%) was significantly greater than the rate with 5 µg of HepB (84.3%) (P<0.05). The anti-HBs seroconversion rates after the third booster dose with 5 or 10 μg of HepB were greater than those after the first booster dose (99.6% and 99.7%, vs. 90.3% and 93.6%, P<0.05); as was the corresponding GMTs (658 ± 4 mIU/ml and 2599 ± 3 mIU/ml, vs. 255 ± 11 mIU/ml and 877 ± 11 mIU/ml [P<0.05]). The immunization effects of booster vaccination with 3 doses of HepB with 5 or 10 µg are effective; a single booster dose with 10 µg of HepB for 10-15-y-old boys and with 5 or 10 µg of HepB for 5-9 y old boys and for 5-15-y-old girls are effective in generating protective antibody against HBV; however, for anti-HBs-negative children after a single dose of booster, 3 doses are needed.
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou, PR China.
authors.forename: Yongdi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou, PR China.
authors.forename: Huakun
authors.initials: H
authors.lastname: Lv
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Gu
authors.affiliation: Chinese National Center for Disease Control and Prevention; Beijing, PR China.
authors.forename: Fujiang
authors.initials: F
authors.lastname: Cui
authors.affiliation: Chinese National Center for Disease Control and Prevention; Beijing, PR China.
authors.forename: Fuzhen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou, PR China.
authors.forename: Shichang
authors.initials: S
authors.lastname: Xia
authors.affiliation: Chinese National Center for Disease Control and Prevention; Beijing, PR China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007074:Immunoglobulin G / Q000097:blood; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D007074:Immunoglobulin G
keywords: booster vaccination; different dosages; effect; hepatitis B vaccine