title: Effects of zinc supplementation on serum zinc and leptin levels, BMI, and body composition in hemodialysis patients.
abstract: METHODS
  The aim of this study was to determine the effects of zinc supplementation on serum zinc and leptin levels as well as on anthropometric status and some biochemical parameters in hemodialysis (HD) patients.
  
  
  METHODS
  In this randomized, double-blind, and placebo-controlled trial, sixty HD patients were randomly divided into groups to receive a daily supplement of 100mg elemental Zn (supplemented group) or placebo (control group) for 60 days. Anthropometric measurements were taken using standard calibrated instruments. Serum zinc and leptin levels were determined by atomic absorption and ELISA method respectively before and after intervention.
  
  
  RESULTS
  Zinc supplementation resulted in significant increase in the mean serum zinc level in the experimental group while changes observed in the placebo group were not significant. The mean serum leptin in women part of the experimental group was decreased significantly after supplementation. After adjusting for age, BMI, body fat (%), serum zinc and dietary Zn intake, a negative and significant association was observed between serum zinc and leptin levels in all subjects (β=-0.33, P=0.03) as a result of Zn supplementation.
  
  
  CONCLUSIONS
  More studies are needed to clarify the mechanisms by which serum leptin level is influenced as a result of zinc supplementation in HD patients.
authors.affiliation: Shahid Beheshti Medical University, Department of Nephrology, Tehran, Iran. Electronic address: hassanargani@hotmail.com.
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.affiliation: Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: mahdavirez@hotmail.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Mahdavi
authors.affiliation: Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: ghorbaniamir@hotmail.com.
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbani-haghjo
authors.affiliation: Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: reza.razzaghi@gmail.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Razzaghi
authors.affiliation: Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Nikniaz_l@yahoo.com.
authors.forename: Leila
authors.initials: L
authors.lastname: Nikniaz
authors.affiliation: Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: sjghaem@tbzmed.ac.ir.
authors.forename: Seyed Jamal
authors.initials: SJ
authors.lastname: Gaemmaghami
mesh_terms: D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis; D015032:Zinc / Q000097:blood* / Q000494:pharmacology*
chemical_list: D020738:Leptin; D015032:Zinc
keywords: BMI; Hemodialysis; Serum leptin; Serum zinc