title: [Endogenous hypertriglyceridemia].
abstract: Endogenous hypertriglyceridemia, which includes familial hypertriglyceridemia and idiopathic hypertriglyceridemia, is characterized by the increased level of VLDL-triglycerides in the blood. Increased production of VLDL from the liver and the decreased catabolism of VLDL-TG in the vessel, which are also the main metabolic features of insulin resistance, have been proposed to be the causes of endogenous hypertriglyceridemia. Genetic factors responsible for endogenous hypertriglyceridemia have been elucidated in several studies, however, these factors have so far not been clearly identified yet; thus the causes of endogenous hypertriglyceridemia would be polygenic. Recent advances in the genetic analytical methods like genome-wide association study would hopefully unveil the whole pictures of endogenous hypertriglyceridemia.
authors.affiliation: Department of Metabolism, Diabetes and Nephrology, Aizu Medical Center, Fukushima Medical University.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Tsukamoto
mesh_terms: D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics / Q000276:immunology; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D012307:Risk Factors; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride