title: Allele-specific suppression of a cell cycle mutant of S. cerevisiae.
abstract: A cell cycle (cdc) mutant of Saccharomyces cerevisiae is described which fails to complement cdc27-1 described by Hartwell et al. 1973), and is designated cdc27-47. Whereas cdc27-1 behaves as a single Mendelian gene (Hartwell et al. 1973), cdc27-47 requires the presence of an additional unlinked gene for expression of temperature-sensitivity. This gene, designated sts47, is present in some, but not all, laboratory wild-type strains. Expression of cdc27-1 is not influenced by STS47. A model for suppression is proposed involving the modification of conformation within a structural or enzyme complex.
authors.affiliation: National Institute for Medical Research, Mill Hill, NW7, London, Great Britain.
authors.forename: K M
authors.initials: KM
authors.lastname: Richmond
authors.forename: D H
authors.initials: DH
authors.lastname: Williamson