title: New potential antitumor pyrazole derivatives: synthesis and cytotoxic evaluation.
abstract: New pyrazole derivatives were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The structures of the compounds were elucidated using spectral and elemental analyses. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative emerged as a potential candidate for the development of future cytotoxic compounds.
authors.affiliation: Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest 020956, Romania. nitulescu_mihai@yahoo.com.
authors.forename: George Mihai
authors.initials: GM
authors.lastname: Nitulescu
authors.forename: Constantin
authors.initials: C
authors.lastname: Draghici
authors.forename: Octavian Tudorel
authors.initials: OT
authors.lastname: Olaru
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003621:Daphnia / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D014908:Triticum / Q000187:drug effects
chemical_list: C436945:3-aminopyrazole; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; C031280:pyrazole