title: Successful treatment of metastasized pancreatic vasoactive intestinal polypeptide-secreting tumor unresponsive to high-dose octreotide by peptide receptor radionuclide therapy using 90Y DOTATATE.
abstract: We report a successful treatment of a patient with heavily metastasized pancreatic vasoactive intestinal polypeptide-secreting tumor, which was unresponsive to high doses of octreotide analog using peptide receptor radionuclide therapy applying a radiolabeled somatostatin analog. After the peptide receptor radionuclide therapy, there was a decrease in vasoactive intestinal polypeptide levels, a significant reduction in somatostatin receptor expression and in molecular tumor volume on 68Ga DOTANOC PET/CT scan, and a complete long-term resolution of symptoms of the patient.
authors.affiliation: From the *Department of Nuclear Medicine, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; and †THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Germany.
authors.forename: Aurora
authors.initials: A
authors.lastname: Sainz-Esteban
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D017481:Receptors, Somatostatin / Q000378:metabolism*; D017211:Treatment Failure; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: C539274:90Y-octreotate, DOTA(0)-Tyr(3)-Thr(8)-; D009942:Organometallic Compounds; D017481:Receptors, Somatostatin; D014660:Vasoactive Intestinal Peptide; D015282:Octreotide