title: Effects of rasagiline on olfactory function in patients with Parkinson’s disease.
abstract: BACKGROUND
  Impairment of olfactory function is a well recognized nonmotor manifestation of Parkinson’s disease(PD). The aim of this investigation was to determine if the MAO-B inhibitor rasagiline can improve olfaction in PD patients.
  
  
  METHODS
  Thirty-four PD patients participated in this single-center, prospective, randomized, controlled,double-blind study. Seventeen patients were randomly assigned to rasagiline and 17 patients to placebo. Orthoand retronasal olfactory testing and recording of event related potentials were performed before and after 120 days of rasagiline versus placebo intake.
  
  
  RESULTS
  When comparing olfactory score differences between baseline and after 120 days between the 2 groups, the level of significance was not reached.
  
  
  CONCLUSIONS
  The primary end point of the study was not reached, and therefore, a specific effect of rasagiline on olfactory function in PD could not be demonstrated.
authors.forename: Antje
authors.initials: A
authors.lastname: Haehner
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
authors.forename: Martin
authors.initials: M
authors.lastname: Wolz
authors.forename: Lisa
authors.initials: L
authors.lastname: Klingelhöfer
authors.forename: Mareike
authors.initials: M
authors.lastname: Fauser
authors.forename: Alexander
authors.initials: A
authors.lastname: Storch
authors.forename: Heinz
authors.initials: H
authors.lastname: Reichmann
mesh_terms: D000281:Administration, Intranasal; D000368:Aged; D004311:Double-Blind Method; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000209:etiology*; D064367:Olfactometry; D010300:Parkinson Disease / Q000150:complications*; D011446:Prospective Studies; D011601:Psychophysics; D011788:Quality of Life; D012720:Severity of Illness Index
chemical_list: D007189:Indans; D018696:Neuroprotective Agents; C031967:rasagiline