title: A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence.
abstract: A novel arylation-cyclization strategy for the highly enantioselective synthesis of titled heterocycles with a quaternary stereogenic center has been developed.
authors.affiliation: State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. xumh@simm.ac.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Dong-Xing
authors.initials: DX
authors.lastname: Zhu
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C484744:5-hydroxyoxindole; D001572:Benzofurans; D002867:Chromones; D007211:Indoles; D000078183:Oxindoles; D012238:Rhodium