title: [The role of peripheral blood eosinophil percentage in classification of chronic rhinosinusitis with nasal polyps].
abstract: OBJECTIVE
  Trying to find a useful marker to subclassify chronic rhinosinusitis (CRS), ratio of eosinophil in peripheral blood was investigated.
  
  
  METHODS
  Histologic characteristics of surgical samples were analyzed in 119 CRS with nasal polyps (CRSwNP) patients, who were classified into eosinophil CRSwNP (ECRSwNP) group and non-ECRSwNP group. Peripheral blood eosinophil percentage, olfactory function, skin prick test, serum total IgE and sinus CT scan in two groups were all examined and analyzed. To evaluate the discriminatory power of eosinophil to diagnose ECRSwNP, the Receiver Operating Characteristic(ROC)curve was analysed.
  
  
  RESULTS
  There were significant differences in Ratio of EOS, serum total IgE, and olfactory function scores, between ECRSwNP group and non-ECRSwNP group(mean value were 7.31%: 3.90%, 60.9 IU/L: 28.9 IU/L, 5.8: 0.4 respectively, U value were 620.01, 1020.53 and 1092.52, respectively, all P < 0.05). However, there was no difference in skin prick test between two groups. In CT scan exam, there were no differences in Lund-Mackay scores in frontal sinus, anterior ethmoid sinus, posterior ethmoid sinus, sphenoid sinus and ostiomeatal complex area, but maxillary sinus, between ECRSwNP group and non-ECRSwNP group (U value were 27.5, 23.5, 22.5, 31.5, 28.5, respectively, all P > 0.05, and U value of maxillary sinus was 12.01, P < 0.05 ). Peripheral blood eosinophil percentage and serum total IgE were related with pathology of nasal polyps (r value were 0.55, 0.24, and P value were 0.001, 0.01, respectively), especially blood eosinophilia can be a predictor of ECRSwNP. The area under curve was 0.818 and cutoff value was 5.65%.
  
  
  CONCLUSIONS
  ECRSwNP is different from non-ECRSwNP in many clinical features. Peripheral blood eosinophil percentage is consistent with histologic features of ECRS, which is a useful marker as 5.65% in classification of CRS.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology, Head and Neck Surgery(Capital Medical University), Ministry of Education, Beijing 100730, China.
authors.forename: Ming-jie
authors.initials: MJ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Yun-chuan
authors.initials: YC
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Huang
mesh_terms: D002908:Chronic Disease; D004804:Eosinophils; D005005:Ethmoid Sinus; D005626:Frontal Sinus; D006801:Humans; D007958:Leukocyte Count; D008443:Maxillary Sinus; D009298:Nasal Polyps / Q000150:complications*; D010256:Paranasal Sinuses; D012372:ROC Curve; D012220:Rhinitis / Q000150:complications / Q000503:physiopathology*; D012852:Sinusitis / Q000150:complications / Q000503:physiopathology*; D012882:Skin Tests; D014057:Tomography, X-Ray Computed