title: Linking the Enzymes that Unlink DNA.
abstract: Two papers in this issue, Castor et al. (2013) and Wyatt et al. (2013), and a third in Cell Reports, Garner et al. (2013), demonstrate that the scaffold protein SLX4 coordinates multiple nucleases in order to effectively resolve Holliday junctions and repair interstrand crosslinks (ICLs) in mammalian cells.
authors.affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: brill@cabm.rutgers.edu.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Brill
mesh_terms: D000818:Animals; D004260:DNA Repair; D045566:DNA, Cruciform; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004706:Endodeoxyribonucleases / Q000378:metabolism*; D004720:Endonucleases / Q000378:metabolism*; D006801:Humans
chemical_list: D045566:DNA, Cruciform; D004268:DNA-Binding Proteins; C480534:Eme1 protein, mouse; D004706:Endodeoxyribonucleases; D004720:Endonucleases; C498773:Mus81 protein, mouse; C585659:SLX1 protein, mouse