title: Insertion/deletion polymorphism of the ACE gene increased risk of Behcet disease: evidence from a meta-analysis.
abstract: OBJECTIVE
  Endothelial dysfunction has a role in the development of the Behcet disease (BD). Local renin-angiotensin system (RAS) plays a crucial role in the endothelial control, and angiotensin-converting enzyme (ACE) is the monitoring component of the RAS. We investigated the relationship between the ACE Ins/Del (I/D) variants and the risk of BD.
  
  
  METHODS
  A meta-analysis was conducted from all published studies on the associations be.tween the ACE I/D polymorphism and BD.
  
  
  METHODS
  We systemically searched all published studies from PubMed and EMBASE, and data were quantitatively synthesized. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele, homozygous, heterozygous, and combined genetic models.
  
  
  RESULTS
  Out of 5 eligible studies, 676 healthy controls and 534 BD cases were included in the present meta.analysis. D allele carrier was significantly associated with increased BD risk (D vs I: P=.002; OR=1.321, 95% CI=1.111-1.570). Homozygous mutant DD genotype also revealed 1.5-fold increased risk (DD vs II; P=.004; OR=1.573, 95% CI=1.156-2.141). In addition, the dominant genetic model demonstrated an increased risk of developing BD (DD vs II+ID: P=.001; OR=1.610, 95% CI=1.242-2.087).
  
  
  CONCLUSIONS
  The current study suggests that ACE gene polymorphism (Ins/Del) contributes an increased susceptibility to BD. However, larger studies with stratified case control population and biological characterization are needed to validate this finding.
authors.affiliation: Dr. Sanjay Khattri, Pharmacology, King George Medical University,, Chowk, Lucknow, Uttar Pradesh, 226004 India, T:+918948577770, F:+91 522 2257539, drsanjaykhattri@gmail.com.
authors.forename: Raju Kumar
authors.initials: RK
authors.lastname: Mandal
authors.forename: Suraj Singh
authors.initials: SS
authors.lastname: Yaday
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Panda
authors.forename: Sanjay
authors.initials: S
authors.lastname: Khattri
mesh_terms: D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D007703:Peptidyl-Dipeptidase A