title: A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model.
abstract: OBJECTIVE
  The gain of mineralized bone was compared between deproteinized bovine bone allograft (DBA) and biphasic calcium phosphate (BCP) for dental implant placement.
  
  
  METHODS
  Five patients with atrophic maxillae underwent bilateral sinus elevation with DBA (Bio-Oss) and BCP (Straumann BoneCeramic). After 3 to 8 months, 32 Camlog implants were placed, and biopsies were retrieved. Bone and graft volume, degree of bone mineralization, and graft degradation gradient were determined using micro-computed tomography, and bone formation and resorption parameters were measured using histomorphometry. Implant functioning and peri-implant mucosa were evaluated up to 4 years.
  
  
  RESULTS
  Patients were prosthetically successfully restored. All but one of the implants survived, and peri-implant mucosa showed healthy appearance and stability. Bone volume, graft volume, degree of bone mineralization, and osteoclast and osteocyte numbers were similar, but BCP-grafted biopsies had relatively more osteoid than DBA-grafted biopsies.
  
  
  CONCLUSIONS
  The BCP and DBA materials showed similar osteoconductive patterns and mineralized bone, although signs of more active bone formation and remodeling were observed in BCP- than in DBA-grafted biopsies.
authors.affiliation: Academic Center Oral Implantology Amstelveen, Amstelveen, The Netherlands.
authors.forename: Gert L
authors.initials: GL
authors.lastname: de Lange
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Janice R
authors.initials: JR
authors.lastname: Overman
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Farré-Guasch
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Clara M
authors.initials: CM
authors.lastname: Korstjens
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Hartman
authors.affiliation: Department of Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Geerling E J
authors.initials: GE
authors.lastname: Langenbach
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
authors.forename: Marion A
authors.initials: MA
authors.lastname: Van Duin
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, and VU University Amsterdam, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands. Electronic address: j.kleinnulend@acta.nl.
authors.forename: Jenneke
authors.initials: J
authors.lastname: Klein-Nulend
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002417:Cattle; D003758:Dental Implantation, Endosseous; D005260:Female; D005500:Follow-Up Studies; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates