title: Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions.
abstract: Drug transporters, together with drug metabolic enzymes, are major determinants of drug disposition and are known to alter the response to many commonly used drugs. Substantial frequency differences for known variants exist across geographic regions for certain drug transporters. To deliver efficacious medicine with the right dose for each patient, it is important to understand the contribution of genetic variants for drug transporters. Recently, mutual pharmacokinetic data usage among Asian regions, which are thought to be relatively similar in their own genetic background, is expected to accelerate new drug applications and reduce developmental costs. Polymorphisms of drug transporters could be key factors to be considered in implementing multiethnic global clinical trials. This review addresses the current knowledge on genetic variations of major drug transporters affecting drug disposition, efficacy and toxicity, focusing on the east Asian populations, and provides insights into future directions for precision medicine and drug development in east Asia.
authors.affiliation: Department of Clinical Pharmacology, Clinical Research, Pfizer Japan Inc., 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Ono
authors.forename: Hironori
authors.initials: H
authors.lastname: Kikkawa
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Suzuki
authors.forename: Misaki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Katsuomi
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Masato
authors.initials: M
authors.lastname: Fukae
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ieiri
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D064423:Drug Trafficking; D005006:Ethnicity / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
chemical_list: D018528:ATP-Binding Cassette Transporters