title: Surgical management of aortitis with early aneurysmal dilation.
abstract: BACKGROUND
  Aortitis is a rare and serious condition that requires expedient surgical evaluation. Diagnosis is generally made by computed tomography (CT). Surgery is most often performed when significant aneurysmal changes have already occurred. Outcomes of early surgical management of aortitis with early aneurysmal dilation have not been reported previously.
  
  
  METHODS
  A retrospective review of open abdominal aortic repairs performed from 1999 to 2009 at a single center was done from a prospectively collected database. Patients with a confirmed radiographic appearance of aortitis and treated surgically were selected. Demographic, clinical, and surgical data of patients with aortitis showing early aneurysmal changes (aortic diameter <4 cm) were then analyzed. All aortitis cases with >4-cm aortic diameters and with prosthetic aortic grafts were excluded.
  
  
  RESULTS
  During the observation period, 421 open abdominal aortic repairs were performed. Of these, 10 (2.4%) were identified as having primary aortitis without significant aneurysmal changes. The mean age of the patients was 62 (range 48-77) years. There were 6 (60%) men and 4 (40%) women in the cohort. Four patients (40%) had culture-negative aortitis, whereas 6 (60%) had positive microbial cultures at the time of diagnosis. Paravisceral involvement was seen in 8 (80%) cases. All patients underwent in situ repair with aortic homografts. Mean operative time was 348 minutes and mean estimated blood loss was 2475 mL. Median follow-up time was 23.1 months with a range of 1.7-51.4 months. Operative mortality was 0%, and 1 late death occurred at 23 months postoperatively. There were 9 significant in-hospital (30-day) events occurring in 5 patients, including 3 cardiovascular events, 2 pulmonary events, 3 acute renal failures, and 1 deep surgical site infection.
  
  
  CONCLUSIONS
  Aortitis is an uncommon indication for aortic repair. Infectious aortitis is most commonly confirmed by microbiologic studies, but a significant number of cases have no demonstrable microbial source. Outcomes after early surgical management for aortitis with small aneurysms demonstrated improved mortality when compared with series reviewing outcomes in aortitis patients with large mycotic aneurysms.
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Cheong J
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Melina R
authors.initials: MR
authors.lastname: Kibbe
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Eskandari
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Morasch
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: William H
authors.initials: WH
authors.lastname: Pearce
authors.affiliation: Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address: herodrig@nmh.org.
authors.forename: Heron E
authors.initials: HE
authors.lastname: Rodriguez
mesh_terms: D000368:Aged; D000785:Aneurysm, Infected / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000382:microbiology / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D001025:Aortitis / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D001027:Aortography / Q000379:methods; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D004108:Dilatation, Pathologic; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome