title: Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells.
abstract: The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.
authors.affiliation: Department of Molecular Microbiology and Immunology; Norris Comprehensive Cancer Center; Keck School of Medicine; University of Southern California; Los Angeles, CA USA.
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Wen
authors.forename: Ran
authors.initials: R
authors.lastname: Xiong
authors.forename: Zhengxi
authors.initials: Z
authors.lastname: Dai
authors.forename: Seil
authors.initials: S
authors.lastname: Kim
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lawrenczyk
authors.forename: Weiming
authors.initials: W
authors.lastname: Yuan
keywords: CD1d; anticancer therapy; humanized mice; iNKT cells; immunotherapy