title: ST-segment elevation myocardial infarction treated with thrombolytic therapy in a patient with thrombotic thrombocytopenic purpura.
abstract: Acute myocardial infarction is a common complication of thrombotic thrombocytopenic purpura (TTP), but rarely the presenting manifestation. Anti-thrombotic therapy for myocardial infarction is rarely utilized in the setting of TTP because of elevated bleeding risk. We report a case of TTP presenting with ST-segment elevation myocardial infarction and treated with thrombolytic therapy. The resultant cardiac and neurological complications highlight the challenges of using evidence-based therapy for myocardial infarction in the setting of TTP.
authors.affiliation: Duke University Medical Center, 2301 Erwin Road, DUMC 3845, Durham, NC, 27710, USA, jacob.doll@duke.edu.
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Doll
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Kelly
mesh_terms: D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*