title: Theoretical study of amino derivatives and anticancer platinum drug grafted on various carbon nanostructures.
abstract: Density functional theory calculations with van der Waals approximation have been conducted to analyze the functionalization of various carbon-based nanostructures (fullerene, metallic, and semi-conducting nanotubes) with amino derivative groups. The results obtained with azomethine, show the formation of a five membered ring on fullerenes, and on nanotubes consistent with experimental observations. The attachment of an azomethine plus subsequent drug like a Pt(IV) complex does not perturb the cycloaddition process. Moreover, all theoretical results show that the length of different amino derivatives with subsequent Pt(IV) complex does not affect the complexed therapeutic agent when it is attached onto these carbon-based nanostructures.
authors.affiliation: Laboratoire de Nanomédecine, Imagerie et Thérapeutique, EA4662, Université de Franche-Comté, CHU de Besançon 16 route de Gray, 25030 Besançon Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Kraszewski
authors.forename: E
authors.initials: E
authors.lastname: Duverger
authors.forename: C
authors.initials: C
authors.lastname: Ramseyer
authors.forename: F
authors.initials: F
authors.lastname: Picaud
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry*; D011789:Quantum Theory; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001391:Azo Compounds; D037742:Nanotubes, Carbon; D009944:Organoplatinum Compounds; D013882:Thiosemicarbazones; C512188:azomethine; D002244:Carbon