title: Diabetes mellitus as predictor of patient and graft survival after kidney transplantation.
abstract: BACKGROUND
  In this study, we used a single-center database to examine the risks of renal transplantation in patients with diabetes mellitus (DM). We aimed to compare 1-year outcomes of survival and morbidity after renal transplantation among recipients with and without DM.
  
  
  METHODS
  We reviewed retrospectively 1211 adult patients who underwent renal transplantation from January 2001 to December 2010. The patients were divided into 2 groups: Those with (33%) and those without (67%) pretransplant diabetes. Unpaired Student's t tests and χ(2) tests were used to compare outcomes between diabetic and nondiabetic renal transplant recipients. We analyzed survival, renal function, development of proteinuria, rejection, and infection (requiring hospitalization).
  
  
  RESULTS
  Patients with diabetes were older, had a greater body mass index (mean, 29.5 vs 25.3 kg/m(2); P < .05), and had lower creatinine clearance (44.2 ± 11.4 vs 56.0 ± 18.2; P = .01). Forty-one patients died in hospital (3.4%; P = nonsignificant). Furthermore, survival rates were similar between these 2 groups. However, we found a trend toward decreased survival for those with DM at 1 year (80.4% vs 88.7%; P = .20). Mean follow-up time was 3.2 years. Infection rate within 6 months was greater among those with DM (19% vs 5%; odds ratio, 6.25). Freedom from rejection at 3 years was similar (75.2% vs 76.8%; P = .57). Multivariate analysis showed increased baseline creatinine level as a significant risk factor for survival. Body mass index >30 kg/m(2) was a significant risk factor for survival among patients with DM.
  
  
  CONCLUSIONS
  We found an increased risk of serious infections in patients with DM, particularly within the first 6 months. However, our data suggest that diabetes is not associated with worse 1-year survival or higher morbidity in renal transplant patients, as long as good blood glucose control is maintained.
authors.affiliation: Internal Medicine and Nephrology Department, Cairo University, Cairo, Egypt. Electronic address: hodamamoun@yahoo.com.
authors.forename: H A H
authors.initials: HA
authors.lastname: Maamoun
authors.forename: A R
authors.initials: AR
authors.lastname: Soliman
authors.forename: A
authors.initials: A
authors.lastname: Fathy
authors.forename: M
authors.initials: M
authors.lastname: Elkhatib
authors.forename: N
authors.initials: N
authors.lastname: Shaheen
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis