title: The unconventional embryo: immune-restricted potential precedes multipotentiality.
abstract: Little is currently known about the developmental origins of the immune system and the lineage restriction processes that lead to its establishment. In this issue, Böiers et al. (2013) now demonstrate immune-restricted potential originating from the yolk sac even before the emergence of the first hematopoietic stem cells.
authors.affiliation: Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0XY, UK.
authors.forename: Camille
authors.initials: C
authors.lastname: Malouf
authors.forename: Katrin
authors.initials: K
authors.lastname: Ottersbach
mesh_terms: D000818:Animals; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008297:Male