title: Genome sequence of a novel HIV-1 circulating recombinant form (CRF64_BC) identified from Yunnan, China.
abstract: We report a novel HIV-1 circulating recombinant form (CRF64_BC) that was isolated from five epidemiologically unlinked HIV-infected persons in Yunnan province. CRF64_BC was composed of subtype B and subtype C, with five short subtype B segments inserted into the subtype C backbone. Phylogenetic analysis demonstrated that the C subregion was correlated with the India C lineage, which was transmitted into China in the early 1990s. The evolutionary history of the B subregion was not as clear as the C subregion, as the short length of this region yielded poor phylogenetic results. Dehong is considered the epicenter of HIV-1 in China, and recombinant strains such as CRF07_BC and CRF08_BC, which also originated from this region, have spread widely in China. The newly emerged CRF64_BC increases the complexity of the HIV epidemic in China and complicates the development of subtype-specific tools against HIV transmission.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Chinese Center for Disease Control and Prevention, Beijing, China .
authors.forename: Jenny
authors.initials: J
authors.lastname: Hsi
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.forename: Manhong
authors.initials: M
authors.lastname: Jia
authors.forename: Nidan
authors.initials: N
authors.lastname: Wang
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Ning
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000328:Adult; D002681:China; D016000:Cluster Analysis; D019143:Evolution, Molecular; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D012328:RNA Viruses / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral