title: [PDT panoramic view. Principle, photosensitizers, light sources and validated indications in dermatology].
abstract: BACKGROUND
  Photodynamic therapy (PDT) combines the use of a topical sensitizer and its excitation with a light of appropriate wavelength. Its use in dermatooncology has been possible in France in 2006 when the methyl ester ALA or Metvixia® got approved.
  
  
  OBJECTIVE
  To provide a panoramic view of validated indications of PDT in oncodermatology.
  
  
  METHODS
  This work is based on the review of the literature as well as available guidelines or recommendation on PDT in dermatology.
  
  
  RESULTS
  Standardized protocols and results of the main clinical trials are given for the three major indications in dermatology: actinic keratosis, basal cell carcinoma and Bowen disease.
  
  
  CONCLUSIONS
  PDT has its role to play in the treatment of multiple superficial carcinomas and cutaneous precancerous lesions and its main advantage resides in its optimal healing.
authors.affiliation: Service de Dermatologie, Hôpital Saint Louis, 1 avenue Claude Vellefaux 75475 Paris cedex 10, France. Electronic address: nicole.basset-seguin@sls.aphp.fr.
authors.forename: N
authors.initials: N
authors.lastname: Basset-Seguin
mesh_terms: D000622:Aminolevulinic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D001913:Bowen's Disease / Q000188:drug therapy; D002280:Basal Cell Carcinoma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy; D010146:Pain / Q000209:etiology; D010778:Photochemotherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011230:Precancerous Conditions / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid
keywords: Actinic keratosis; Basal cell carcinoma; Bowen's disease; Carcinome basocellulaire superficiel; Kératoses actiniques; Maladie de Bowen; Photodynamic therapy.; Photothérapie dynamique