title: Influence of Stromal Components on Lung Cancer Carcinogenesis.
abstract: The association between tumor growth and angiogenesis was first observed over 100 years ago. Since then, research has shown the dependence of tumor growth on angiogenesis and the ability of cancer cells to alter the stromal microenvironment. Technological advancements have enabled researchers to identify cell types within a tumor, identify chemokines, cytokines, and growth factors secreted by tumor cells, show the interaction between tumor cells and stroma, and investigate the function of distinct genes using knockout and transgenic mouse technology. This review provides an overview of tumor growth, emphasizing research usingin vivomouse models on vascular endothelial growth factor (VEGF), fibrinogen, fibronectin, plasminogen, and MMPs in primary tumor growth and metastasis of lung cancer in particular.
authors.affiliation: Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1500, USA.
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Shuman Moss
authors.forename: William G
authors.initials: WG
authors.lastname: Stetler-Stevenson
keywords: Fibrinogen; Fibronectin; Lung cancer; Matrix metalloproteinases; Plasminogen; TIMPs; VEGF