title: Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles.
abstract: OBJECTIVE
  To elucidate the role of vitamin D in reproduction by examining the relationship between recipient vitamin D levels and pregnancy rates in donor-recipient IVF cycles.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Academic tertiary care center.
  
  
  METHODS
  Ninety-nine recipients of egg donation at University of Southern California Fertility.
  
  
  METHODS
  Serum was collected from egg donor recipients before ET and was tested for vitamin D levels [25(OH)D].
  
  
  METHODS
  Clinical pregnancy as defined by sonographic presence of a heartbeat at 7-8 weeks of gestation.
  
  
  RESULTS
  In a diverse population of 99 recipients (53% Caucasian, 20% Asian, 16% Hispanic, 7% African American), adjusted clinical pregnancy rates were lower among vitamin D-deficient recipients than among vitamin D-replete recipients (37% vs. 78%). Live-birth rates were 31% among vitamin D-deficient recipients, compared with 59% among vitamin D-replete recipients. There were no differences in adjusted clinical pregnancy and live-birth rates among recipients who were vitamin D deficient [25(OH)D<20 ng/mL] vs. among those who were vitamin D insufficient [20 ng/mL ≤ 25(OH)D<30 ng/mL].
  
  
  CONCLUSIONS
  Nonreplete vitamin D status [25(OH)D<30 ng/mL] was associated with lower pregnancy rates in recipients of egg donation. Since the oocyte donor-recipient model is able to separate the impact of vitamin D on oocyte vs. endometrium, these data suggest that the effects of vitamin D may be mediated through the endometrium.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Center for Women's Reproductive Health, Columbia University, New York, New York. Electronic address: briana.rudick@gmail.com.
authors.forename: Briana J
authors.initials: BJ
authors.lastname: Rudick
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Sue Ann
authors.initials: SA
authors.lastname: Ingles
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Los Angeles, California.
authors.forename: Karine
authors.initials: K
authors.lastname: Chung
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Los Angeles, California.
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Los Angeles, California.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Paulson
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Los Angeles, California.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Bendikson
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000592:standards*; D006801:Humans; D018587:Oocyte Donation / Q000592:standards*; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies; D014019:Tissue Donors; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D014807:Vitamin D
keywords: 25-hydroxyvitamin D; IVF; Vitamin D; endometrium; race; recipients of egg donation