title: The association of resistin with coronary disease in the general population.
abstract: OBJECTIVE
  To explore the association between resistin expression and the incidence of ischemic heart disease in the general population.
  
  
  METHODS
  A follow-up study of 6636 adults recruited randomly from the general population.
  
  
  RESULTS
  The serum resistin concentration was higher in women (6.1 ng/mL; CI95%=6.0-6.2) than in men (5.6 ng/mL; CI95%=5.5-5.7). Individuals in the 5th quintile or higher of resistin (RQ5) were younger (P＜0.001) and had a lower prevalence of arterial hypertension (P＜0.001), abdominal obesity (P＜0.001), diabetes (P＜0.001) and dyslipidemia (P＜0.001). The cardiovascular risk estimated by the Framingham function was also lower in the RQ5 subgroup (P＜0.001); however, the prevalence of smoking was higher (P＜0.001), as was the prevalence of low HDL cholesterol (P＜0.001). After 3.5 years of follow-up, the RQ5 subgroup had a higher incidence of acute myocardial infarction (AMI, RR=1.9; CI95%=1.01-3.54). In the population without diabetes, the RQ5 subgroup had a higher risk of AMI (RR=2.4; CI95%=1.10-5.17), and the risk of AMI was highest in women in this group (4.97; CI95%=1.33-18.57). The risk levels were significant in the Cox models adjusted for age, sex and smoking; and the hazard ratio was 2.5 for AMI (CI95%=1.29-4.70) in the sample of patients matched by sex and smoking status.
  
  
  CONCLUSIONS
  Resistin may be a risk marker for ischemic heart disease in the general population. The serum resistin concentration is higher in women, and the associated increase in the risk of AMI based on the resistin level is also higher in women than in men.
authors.affiliation: Research Unit, at Candelaria University Hospital.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cabrera de León
authors.forename: Delia
authors.initials: D
authors.lastname: Almeida González
authors.forename: Ana
authors.initials: A
authors.lastname: González Hernández
authors.forename: José
authors.initials: J
authors.lastname: Juan Alemán Sánchez
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Brito Díaz
authors.forename: Santiago
authors.initials: S
authors.lastname: Domínguez Coello
authors.forename: Itahisa
authors.initials: I
authors.lastname: Marcelino Rodríguez
authors.forename: José
authors.initials: J
authors.lastname: Gregorio Oliva García
authors.forename: Armando
authors.initials: A
authors.lastname: Aguirre Jaime
authors.forename: María Del Cristo
authors.initials: Mdel C
authors.lastname: Rodríguez Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: D052243:Resistin