title: Usefulness of continuous blood glucose monitoring and control for patients undergoing liver transplantation.
abstract: BACKGROUND
  The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation.
  
  
  METHODS
  Sixteen patients undergoing living-donor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8). The target glucose level range was set at 80-150 mg/dl.
  
  
  RESULTS
  The mean and SD of blood glucose concentration during surgery (Glu-Ave and Glu-SD, respectively) for the programmed insulin group were lower than for the manual insulin group. The coefficient of variability (Glu-CV=Glu-SD×100 /Glu-Ave) for the programmed insulin group was also lower than for the manual insulin group (20.1±4.9% vs. 26.9±6.1%; mean±SD). No hypoglycemia was detected in either group.
  
  
  CONCLUSIONS
  The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration.
authors.affiliation: Department of Anesthesia, Takamatsu Red Cross Hospital.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Okada
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawahito
authors.forename: Naoji
authors.initials: N
authors.lastname: Mita
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitahata
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Shuzo
authors.initials: S
authors.lastname: Oshita
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D007430:Intraoperative Care; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose