title: The unusual presentation of a usual organism - the changing spectrum of the clinical manifestations of Plasmodium vivax malaria in children: a retrospective study.
abstract: BACKGROUND
  Malaria is a major public health problem in the south-east Asian region. Among all countries in the SE Asian region the highest number of cases and deaths are reported from India. Children below 14 years of age contribute to approximately 42% of all the deaths. A majority of the deaths are attributed to severe malaria which is caused by Plasmodium falciparum. It is considered that causes a benign causing febrile illness without significant complications. However, in recent years, the spectrum of is shifting from being the cause of benign fever, to more severe complications. There have been case reports of complications like thrombocytopaenia, cerebral malaria, a disseminated intravascular coagulation, the acute respiratory distress syndrome, hepatic dysfunction and renal involvement. Most of the case reports are from the adult population, with an occasional occurrence of paediatric cases.
  
  
  OBJECTIVE
  To highlight the increasing number of severe manifestations in P.vivax malaria in the children who were admitted in the malaria transmission season of 2011, at a tertiary care hospital.
  
  
  METHODS
  A descriptive, cross-sectional study.
  
  
  METHODS
  
  
  
  METHODS
  Children with an acute febrile illness of a duration of < 7 days, which was confirmed as Plasmodium vivax positive malaria by testing the peripheral smears and/or by Rapid Diagnostic Testing, who were admitted in the paediatric ward of a tertiary care hospital in New Delhi (India), during May 2011 to October 2011, Case records of context cases were analysed retrospectively.
  
  
  METHODS
  The data was summarised by calculating the rates, ratios, proportions, means, standard deviations and the 95% confidence intervals. The Chi square test was applied to assess the significant difference between two qualitative variables.
  
  
  RESULTS
  Among the case records of 54 patients, 40.7% were below 5 years. 61% were males and 38.9% were females. Besides hepatomegaly and splenomegaly which were the most common symptoms, which were seen in 81.5% and 72.2% children respectively, the various unusual manifestations seen were severe thrombocytopaenia (37%), jaundice with deranged LFT values (25.9%), abnormal bleeding (18.5%), impaired consciousness with a GCS of < 9 (18.5%), severe anaemia (14.8%), hypotension (11.1%), repeated convulsions (7.6%), pulmonary oedema/ARDS (5.6%) and ascites (5.6%). One case each showed haemoglobinuria, and pleural effusion.
  
  
  CONCLUSIONS
  Plasmodium vivax is emerging as a cause of severe malaria. There is a further need to study the pathophysiology, virulence factors and the molecular mechanisms which are involved in malaria.
authors.affiliation: Associate Professor, Vardhman Mahavir Medical College and Safdarjung Hospital , New Delhi, India .
authors.forename: Shobha
authors.initials: S
authors.lastname: Sharma
authors.forename: Kailash Chandra
authors.initials: KC
authors.lastname: Aggarwal
authors.forename: Shivani
authors.initials: S
authors.lastname: Deswal
authors.forename: Deepak
authors.initials: D
authors.lastname: Raut
authors.forename: Neelam
authors.initials: N
authors.lastname: Roy
authors.forename: Rohit
authors.initials: R
authors.lastname: Kapoor
keywords: Children; Complications; Plasmodium vivax malaria