title: CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life.
abstract: Harmful effects caused by the absorption of ultraviolet (UV) light can be reduced by using sunscreens. The long-wavelength UV (UVA) and short-wavelength UV (UVB) protective effects of an azobenzene compound, 4-cholesterocarbonyl-4'-(N,N'-diethylaminobutyloxy) azobenzene (CDBA) liposomal formulation, especially its repeated photo-isomerization were evaluated in the presence of substrates such as propylene glycol and glycerol. It was indicated that periodic UV and visible light irradiation did not affect the photo-isomerization and the structure of CDBA-liposome. The stability and photo-isomerization of CDBA-liposomes were not affected by coexistence of 5% propylene glycol and 5% glycerol. CDBA-liposomes could still perform photo-controlled release of encapsulated active component when mixed with propylene glycol. Moreover, the CDBA-liposome mixed with the cream substrate showed protective function for both UVA and UVB in vitro. The in vivo tests using nude mouse confirmed that the CDBA-liposome could provide a good UV protective efficacy with longer shelf life. Therefore, CDBA-liposomes have the potential using as a new type of commercial sunscreen.
authors.affiliation: School of Biomedical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Shengyong
authors.initials: S
authors.lastname: Geng
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Dai
authors.forename: Geng
authors.initials: G
authors.lastname: Qin
authors.forename: Jin-Ye
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002725:Chloroform / Q000737:chemistry; D002784:Cholesterol / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005990:Glycerol / Q000737:chemistry; D006207:Half-Life; D007536:Isomerism; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: C000589417:4-cholesterocarbonyl-4'-(N,N'-diethylaminobutyloxy)azobenzene; D001391:Azo Compounds; D008081:Liposomes; D013473:Sunscreening Agents; D002725:Chloroform; D002784:Cholesterol; C009850:azobenzene; D005990:Glycerol
keywords: CDBA-liposome; Longer shelf life; Photo-isomerization; Sunscreen cosmetic; Ultraviolet irradiation