title: Impaired electro-genesis in skeletal muscle fibers of transgenic Alzheimer mice.
abstract: Alzheimer's disease (AD) is characterized by memory decline, but is often associated with non-cognitive symptoms, including muscular dysfunction. In the majority of cases these motor disturbances are seen when other neuro-degenerative disorders such as Parkinson's disease overlap dementia, however these can also be directly related to AD itself. Although the patho-mechanism remains largely unclear, β-amyloid peptide (βAP) is thought to be a key role-player in both the brain and periphery. Here we studied the electro-genesis of skeletal muscle fibers in a mouse transgenic AD model. Membrane potential was recorded by standard electro-physiological techniques. Compared to wild-type rodents, AD mice show severe disturbances in skeletal muscle electro-genesis manifested by significant depolarization of myo-fibers. These changes are not affected by short-term βAP treatment, the mark of a chronic degenerative process in the periphery directly related to AD whereby ion pumps on muscle membranes exhibit reduced activity. This phenomenon may explain ionic imbalance and cellular dysfunction both in the neuro-muscular system and in the brain. The observed motor disturbances might play a key role in impaired activities of daily living, and addressing the muscular patho-physiology could improve quality of life in AD.
authors.affiliation: Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia. Electronic address: maratm80@list.ru.
authors.forename: Marat Alexandrovich
authors.initials: MA
authors.lastname: Mukhamedyarov
authors.affiliation: Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia.
authors.forename: Evgeniy Mikhailovich
authors.initials: EM
authors.lastname: Volkov
authors.affiliation: Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia.
authors.forename: Dilyara Fanisovna
authors.initials: DF
authors.lastname: Khaliullina
authors.affiliation: Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia.
authors.forename: Pavel Nikolaevich
authors.initials: PN
authors.lastname: Grigoryev
authors.affiliation: Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia.
authors.forename: Andrey Lvovich
authors.initials: AL
authors.lastname: Zefirov
authors.affiliation: Asklepios-Med (Private Medical Practice and Research Center), Kossuth Lajos sgt. 23, H-6722 Szeged, Hungary. Electronic address: palotas@asklepios-med.eu.
authors.forename: András
authors.initials: A
authors.lastname: Palotás
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*
chemical_list: C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor
keywords: Activities of daily living; Alzheimer’s disease; Motor dysfunction; Neuro-degeneration; Non-cognitive symptoms; Resting membrane potential; β-Amyloid peptide