title: O-Perfluoroalkylation of 4-hydroxyphenylglycine.
abstract: Racemic N-Boc-4-difluoromethoxyphenylglycine was prepared by O-difluoromethylation of D-N-Boc-4-hydroxyphenylglycine under basic conditions, whereas the hexafluoropropylation reaction gives optically pure D-N-Boc-4-hexafluoropropoxyphenylglycine. D,L-4-difluoromethoxyphenylglycine was obtained by the action of TFA on the corresponding amino acid derivative.
authors.affiliation: Institute of Bioorganic and Oil Chemistry, Ukrainian Academy of Sciences, Murmanskaya, 1, 253660, Kiev, Ukraine.
authors.forename: M T
authors.initials: MT
authors.lastname: Kolycheva
authors.forename: I I
authors.initials: II
authors.lastname: Gerus
authors.forename: V P
authors.initials: VP
authors.lastname: Kukhar