title: An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water.
abstract: A simple, mild, green, catalytic and general procedure for the direct synthesis of highly functionalized 1-methoxycarbonyl-2-aryl/alkyl-3-nitro-9H-carbazoles has been achieved in water medium via a one-pot domino Michael-Henry/aromatization reaction of methyl 2-(3-formyl-1H-indol-2-yl)acetates with aryl/alky-substituted β-nitroolefins under air using DABCO (30 mol%) as an organocatalyst. In addition, the bench scale synthesis can be performed without using toxic organic solvents and a biologically important new fused carbazole has been prepared.
authors.affiliation: Indian Institute of Technology Indore, 452017, Indore, Madhya Pradesh, India. sampaks@iiti.ac.in.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Jaiswal
authors.forename: Soumen
authors.initials: S
authors.lastname: Biswas
authors.forename: Shivendra
authors.initials: S
authors.lastname: Singh
authors.forename: Sampak
authors.initials: S
authors.lastname: Samanta
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D055772:Green Chemistry Technology; D010879:Piperazines / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D002227:Carbazoles; D010879:Piperazines; D014867:Water; C007306:triethylenediamine