title: Effects of dietary restriction or swimming on lymphocytes and macrophages functionality from old rats.
abstract: Although aging compromises the functionality of macrophages (MΦ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenescence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older submitted to 50% of DR (DR) and older submitted to swimming (EX) (n = 10 in each group). The function of immune cells (proliferative index, phagocytic capacity and H₂O₂ production), the weight and protein content of lymphoid organs (thymus and spleen), plasma glutamine concentration, interleukins (IL-1, IL-2, IL-6) and, immunoglobulins (IgA and IgG) were analysed. There was an increase of 74% in body weight in aged animals as compared with the AD group, while body weight reduced 19% in the DR as compared with the OLD group. Swimming training stimulated MΦ phagocytosis, while the EX group presented a decrease of the proliferative capacity of LY from the mesenteric lymph nodes (44% and 62%, respectively), when stimulated with ConA and LPS as compared with the old rats. These data demonstrated that DR and exercise affects differentially MΦ and LY function.
authors.affiliation: School of Physical Education, Mackenzie Presbyterian University , Sao Paulo , Brazil .
authors.forename: Marcela
authors.initials: M
authors.lastname: Meneguello-Coutinho
authors.forename: Erico
authors.initials: E
authors.lastname: Caperuto
authors.forename: Aline Villa Nova
authors.initials: AV
authors.lastname: Bacurau
authors.forename: Grabriela
authors.initials: G
authors.lastname: Chamusca
authors.forename: Marco Carlos
authors.initials: MC
authors.lastname: Uchida
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.forename: Guilherme Borges
authors.initials: GB
authors.lastname: Pereira
authors.forename: James Wilfred
authors.initials: JW
authors.lastname: Navalta
authors.forename: Frederick
authors.initials: F
authors.lastname: Wasinski
authors.forename: Claudia Regina
authors.initials: CR
authors.lastname: Cavaglieri
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
authors.forename: Luis Fernando Bicudo Pereira
authors.initials: LF
authors.lastname: Costa Rosa
authors.forename: Reury Frank
authors.initials: RF
authors.lastname: Bacurau
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D001835:Body Weight; D049109:Cell Proliferation; D002478:Cells, Cultured; D016207:Cytokines / Q000097:blood; D004032:Diet / Q000706:statistics & numerical data*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000706:statistics & numerical data*
chemical_list: D016207:Cytokines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D006861:Hydrogen Peroxide