title: Mucoadhesive polymer films for tissue retraction in laparoscopic surgery: Ex-vivo study on their mechanical properties.
abstract: Safe and effective manipulation of soft tissue during laparoscopic procedures can be achieved by the use of mucoadhesive polymer films. A series of novel adhesive polymer films were formulated in house based on either Carbopol or Chitosan modified systems. The mechanical properties of the polymers and their adherence to bowel were evaluated using ex-vivo pig bowel immersed in 37°C water bath and connected to an Instron tensiometer. Young's modulus was 300 kPa for the Carbopol-polymer and 5 kPa for the Chitosan-polymer. The Chitosan-polymer exhibited much larger shear adhesion than its tensile adhesion: 3.4 N vs. 1.2. Both tensile and shear adhesions contributed to the large retraction force (2.6 N) obtained during l polymer-bowel retraction testing. Work of adhesion at the polymer/serosa interface, defined as the area under the force curve, was 64 mJ, which is appreciably larger than that reported with existing polymers. In conclusion, adhesive polymers can stick to the serosal side of the bowel with an adhesive force, which is sufficient to lift the bowel, providing a lower retraction stress than that caused by laparoscopic grasping which induces high localized pressures on the tissue.
authors.affiliation: Institute of Medical Science and Technology (IMSaT), University of Dundee, Wilson House, MediPark, Dundee DD2 1FD, UK.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Lik-Ren
authors.initials: LR
authors.lastname: Tai
authors.forename: Donald
authors.initials: D
authors.lastname: McLean
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Wright
authors.forename: Gordon J
authors.initials: GJ
authors.lastname: Florence
authors.forename: Stuart I
authors.initials: SI
authors.lastname: Brown
authors.forename: Pascal
authors.initials: P
authors.lastname: Andre
authors.forename: Alfred
authors.initials: A
authors.lastname: Cuschieri
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000269:Adhesives / Q000737:chemistry*; D000578:Amidines / Q000737:chemistry; D000818:Animals; D048271:Chitosan / Q000737:chemistry; D055119:Elastic Modulus; D004867:Equipment Design; D006023:Glycoproteins / Q000737:chemistry; D007422:Intestines / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D009092:Mucous Membrane / Q000473:pathology; D011108:Polymers / Q000737:chemistry*; D012371:Robotics; D033081:Shear Strength; D013314:Stress, Mechanical; D013552:Swine; D013696:Temperature; D013718:Tensile Strength
chemical_list: D000180:Acrylic Resins; D000269:Adhesives; D000578:Amidines; D006023:Glycoproteins; D011108:Polymers; C006912:carboxypolymethylene; D048271:Chitosan
keywords: adhesive force; bowel retraction; laparoscopic surgery; mechanical property; mucoadhesive polymer