title: Fluoride exposure during development affects both cognition and emotion in mice.
abstract: Previous studies have suggested that sodium fluoride (NaF) may have adverse effects on neurodevelopment. In the present study, we evaluated developmental neurotoxicity by assessing in cognitive function and emotional behavior in BalB/C mice treated with NaF. Mice were weaned at 4weeks, and water or different NaF concentrations (2, 5, or 10mg/L in drinking water) were provided for 4weeks. We found that exploration preference in the novel object recognition test was significantly altered in mice treated with 5 and 10mg/L NaF compared with the water-treated control animals. Furthermore, mice treated with 5 and 10mg/L NaF showed significantly longer escape latencies, less time in the target quadrant, and fewer platform-crossing numbers in the Morris water maze compared to those in the control group. In addition, mice treated with 10mg/L NaF spent a lower percentage of time in the open arms in the elevated-plus maze, while no significant changes were noted in the open and close arm entries or the total arm entries. We also found that the cumulative immobility time in the tail suspension test was longer in mice treated with 5 and 10mg/L NaF compared to the control group. Only 10mg/L NaF-treated mice showed longer immobility time compared with the control group. Collectively, our data indicate that developmental exposure to NaF induces cognitive deficits and anxiety-depression-like behaviors in mice.
authors.affiliation: Affiliated Stomatology Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Xing
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Dang
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D006128:Growth / Q000187:drug effects; D046353:Immobility Response, Tonic / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects; D012969:Sodium Fluoride / Q000009:adverse effects*
chemical_list: D012969:Sodium Fluoride
keywords: Cognitive impairment; Emotion-related behavior; Fluoride; Mice; Neurotoxicity