title: Rivaroxaban for the treatment of consumptive coagulopathy associated with a vascular malformation.
abstract: The localized activation of coagulation in vascular malformations can lead to a consumptive coagulopathy characterized by elevated D-dimers and a consumption of fibrinogen and platelets, eventually giving rise to a bleeding tendency. By reducing coagulation activation, anticoagulant treatment with heparin is able to limit this haemostatic dysregulation and the associated bleeding diathesis. Here, we present a case of a consumptive coagulopathy due to a large venous malformation with a sustained correction of the fibrinogen depletion and associated bleeding tendency both with subcutaneous enoxaparin and with the oral factor Xa inhibitor rivaroxaban.
authors.affiliation: Vascular Medicine and Haemostasis, Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Bus 911, 3000, Leuven, Belgium, christophe.vandenbriele@med.kuleuven.be.
authors.forename: Christophe
authors.initials: C
authors.lastname: Vandenbriele
authors.forename: Thomas
authors.initials: T
authors.lastname: Vanassche
authors.forename: Marijke
authors.initials: M
authors.lastname: Peetermans
authors.forename: Peter
authors.initials: P
authors.lastname: Verhamme
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peerlinck
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D065427:Factor Xa Inhibitors / Q000008:administration & dosage*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D009025:Morpholines / Q000008:administration & dosage*; D000069552:Rivaroxaban; D013876:Thiophenes / Q000008:administration & dosage*; D054079:Vascular Malformations / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D065427:Factor Xa Inhibitors; D005338:Fibrin Fibrinogen Degradation Products; D009025:Morpholines; D013876:Thiophenes; C036309:fibrin fragment D; D000069552:Rivaroxaban