title: Measurement of blood-brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data.
abstract: OBJECTIVE
  Increased blood-brain barrier permeability is believed to be associated with complications following acute ischemic stroke and with infarct expansion. Measurement of blood-brain barrier permeability requires a delayed image acquisition methodology, which prolongs examination time, increasing the likelihood of movement artefacts and radiation dose. Existing quantitative methods overestimate blood-brain barrier permeability when early phase CT perfusion data are used. The purpose of this study is to develop a method that yields the correct blood-brain barrier permeability value using first-pass perfusion CT data.
  
  
  METHODS
  We acquired 43 CT perfusion datasets, comprising experimental (n = 30) and validation subject groups (n = 13). The Gjedde-Patlak method was used to estimate blood-brain barrier permeability using first-pass (30-60 s after contrast administration) and delayed phase (30-200 s) data. In the experimental group, linear regression was used to obtain a function predicting first-pass blood-brain barrier permeability estimates from delayed phase estimates in each stroke compartment. The reliability of prediction with this function was then tested using data from the validation group.
  
  
  RESULTS
  The predicted delayed phase blood-brain barrier permeability was strongly correlated with the measured delayed phase value (r = 0.67 and 0.6 for experimental and validation group respectively; p < 0.01). Predicted and measured delayed phase blood-brain barrier permeability in each stroke compartment were not significantly different in both experimental and validation groups.
  
  
  CONCLUSIONS
  We have developed a method of estimating blood-brain barrier permeability using first-pass perfusion CT data. This predictive method allows reliable blood-brain barrier permeability estimation within standard acquisition time, minimizing the likelihood of motion artefacts thereby improving image quality and reducing radiation dose.
authors.affiliation: Centre for Advanced Imaging, The University of Queensland, Australia.
authors.forename: Giang Truong
authors.initials: GT
authors.lastname: Nguyen
authors.forename: Alan
authors.initials: A
authors.lastname: Coulthard
authors.forename: Andrew
authors.initials: A
authors.lastname: Wong
authors.forename: Nabeel
authors.initials: N
authors.lastname: Sheikh
authors.forename: Robert
authors.initials: R
authors.lastname: Henderson
authors.forename: John D
authors.initials: JD
authors.lastname: O'Sullivan
authors.forename: David C
authors.initials: DC
authors.lastname: Reutens
keywords: Blood–brain barrier permeability; Delayed phase; First-pass; Perfusion CT