title: Three polymorphisms of ALOX5AP and risk of ischemic stroke in Chinese: evidence from a meta-analysis.
abstract: The impacts of three polymorphisms (SG13S114A/T, SG13S89A/G and SG13S32A/C) of 5-lipoxygenase activating protein (ALOX5AP) on the risk of ischemic stroke (IS) have been extensively studied for Chinese people, while conflicting results have been reported. The aim of meta-analysis was to further explore the associations to get a more robust conclusion. We researched the databases of Medline, Embase and Wangfang with latest update of August 1st, 2013. Odds ratio and corresponding 95% confidence interval (OR and 95%CI) were used to present the strength of the associations. Eleven case-control studies with 11,037 Chinese peoples (5361 IS cases and 5676 controls) were included. Overall, combined analysis indicated that AA genotype of ALOX5AP SG13S114A/T was significantly associated with increased risk of IS incidence compared with TT genotype [OR and 95%CI: 1.47 (1.13-1.91), P=0.005]. In addition, when subgroup analysis was conducted by subtypes of IS (atherothrombotic- or small artery disease-IS, AHS- or SAD-IS), A allele of SG13S114A/T was found to be associated with increased risk of AHS-IS compared with T allele [OR and 95%CI: 1.51 (1.28-1.79), P<0.01 for AA vs. TT, and 1.12 (1.03-1.22), P=0.010 for A carriers v. T carriers]. However, SG13S89A/G and SG13S32A/C were not overall associated with IS incidence. Due to limited number of included studies, subgroup analyses were not conducted for SG13S89A/G and SG13S32A/C polymorphisms. Sensitivity analyses indicated the robustness of all combined analyses, and publication bias was not found. In conclusion, ALOX5AP SG13S114A/T, rather SG13S89A/G and SG13S32A/C, was significantly associated with risk of IS development for Chinese. More studies were required to warrant the findings of this study.
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China. Electronic address: yefeijeffery@126.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Nan-Nuan
authors.initials: NN
authors.lastname: Liu
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Zheng
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhang
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Chen-Mou
authors.initials: CM
authors.lastname: Wang
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Den
authors.affiliation: Department of Neurology of Ren Min Hospital, Hubei University of Medicine, Hubei Province, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002545:Brain Ischemia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human
keywords: 5-Lipoxygenase activating protein; Etiology; Gene; Ischemic stroke; Meta-analysis; Polymorphism