title: Stabilized magnetic cerasomes for drug delivery.
abstract: Doxorubicin hydrochloride (DOX)-loaded magnetic cerasomes (DLMCs) were successfully constructed by loading both hydrophobic Fe3O4 nanoparticles (NPs) and antitumor drug DOX into the aqueous interior of cerasomes via facile one-step construction. A possible explanation is that the hydrophobic Fe3O4 NPs can be trapped inside the aqueous core of cerasomes through the formation of an intermediate Fe3O4/micelle complex. It was found that the loading content of Fe3O4 in DLMCs could reach the maximum at a Fe3O4/lipid molar ratio of 4:1. Moreover, DLMCs demonstrated high superparamagnetism and responded strongly to magnetic fields. In addition, DLMCs had a high encapsulation efficiency of 43.4 ± 4.7% and a high drug loading content of 3.2 ± 1.3%. In comparison to drug-loaded liposomes, DLMCs exhibited higher storage stability and better sustained release behavior. A cellular uptake study showed that the use of an external magnetic field enables a rapid and efficient uptake of DLMCs by cancer cells, resulting in higher capability to kill tumor cells than non-magnetic drug-loaded cerasomes. This study suggests that magnetic cerasome offers a potential and effective drug carrier for anticancer applications.
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Cao
authors.forename: Xiuli
authors.initials: X
authors.lastname: Yue
authors.forename: Xiaoda
authors.initials: X
authors.lastname: Li
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D005290:Ferric Compounds / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D060526:Magnetic Fields; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D008081:Liposomes; D008823:Micelles; C000499:ferric oxide; D004317:Doxorubicin