title: Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma.
abstract: The aim of this study was to investigate the expression of Nrf2, sulfiredoxin and DJ1 in pancreatic cancer. The expression of Nrf2, sulfiredoxin and DJ1 was studied immunohistochemically in a large set of pancreatic adenocarcinomas consisting of 103 cases. Eighty six percent of the cases showed cytoplasmic Nrf2 and 24% nuclear Nrf2 positivity. Sulfiredoxin positivity was observed in 54% and DJ1 positivity in all cases. Nuclear Nrf2 positivity had an association with sulfiredoxin (p=0.019) and was associated with a poor survival (p=0.010). Stage IV tumors tended to have a more nuclear Nrf2 expression (p=0.080). DJ1 expression was more often found in well-differentiated tumors (p=0.012), and DJ1 expression was associated with better survival (p=0.020). According to the results, nuclear Nrf2 expression predicts a worse survival in pancreatic adenocarcinoma, which is in keeping with its protection of cells against oxidative or xenobiotic stress. In accordance with Nrf2's regulation of the synthesis of sulfiredoxin, there was an association between them (p=0.019). DJ1 had no association with Nrf2, and its expression predicted a better survival of patients.
authors.affiliation: Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. Electronic address: ylermi.soini@uef.fi.
authors.forename: Y
authors.initials: Y
authors.lastname: Soini
authors.affiliation: Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Eskelinen
authors.affiliation: Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Juvonen
authors.affiliation: Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
authors.forename: V
authors.initials: V
authors.lastname: Kärjä
authors.affiliation: Department of Pathology, University of Oulu, Finland.
authors.forename: K M
authors.initials: KM
authors.lastname: Haapasaari
authors.affiliation: Department of Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Saarela
authors.affiliation: Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Karihtala
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000096:biosynthesis; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D051267:NF-E2-Related Factor 2 / Q000032:analysis / Q000096:biosynthesis*; D015513:Oncogene Proteins / Q000032:analysis / Q000096:biosynthesis; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality*; D000071617:Protein Deglycase DJ-1
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1
keywords: Cancer; Carcinoma; Oxidative; Pancreas; Sulfiredoxin