title: Patients with disorders of thrombosis and hemostasis.
abstract: Surgery, by definition, is a challenge to the hemostatic system. In addition, a surgical procedure may provoke inappropriate venous or arterial thrombosis, such as is suggested historically by Virchow's Triad. For these reasons, proper functioning of the hematologic system is integral in a successful and safe perioperative period. Patients with a disorder of either coagulation or hemostasis, therefore, present an exciting challenge to the preoperative physician. Diagnosis of a hematologic disorder may be more or less occult. A proper bleeding and clotting history can serve to elucidate such a disorder and is therefore paramount to the preoperative workup. For those patients with a previously diagnosed disorder of the hematologic system, appropriate laboratory investigation and a concise therapeutic plan for the day of surgery can help to minimize risks in the perioperative period.
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA. Electronic address: orfanaka@ohsu.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Orfanakis
authors.forename: Thomas
authors.initials: T
authors.lastname: Deloughery
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D016736:Antiphospholipid Syndrome / Q000188:drug therapy; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000188:drug therapy; D019937:Diagnostic Techniques and Procedures; D005165:Factor V / Q000235:genetics; D006487:Hemostasis; D006801:Humans; D007430:Intraoperative Care; D009369:Neoplasms / Q000150:complications*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin
keywords: Coagulation; Hemostasis; Perioperative management; Thrombosis