title: Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
abstract: We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.
authors.affiliation: S. N. Bose National Centre for Basic Sciences, Calcutta, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Mehta
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Luck
authors.forename: Collin C
authors.initials: CC
authors.lastname: Luk
authors.forename: Naweed I
authors.initials: NI
authors.lastname: Syed
mesh_terms: D000818:Animals; D008195:Lymnaea / Q000502:physiology*; D008962:Models, Theoretical; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology