title: Antifungal activity of several root canal sealers against Candida albicans.
abstract: OBJECTIVE
  The purpose of this in vitro study was to evaluate the antifungal activity of several root canal sealers (iRoot SP, MTA Fillapex and GuttaFlow) against Candida albicans and compare them to that of AH Plus Jet.
  
  
  METHODS
  A 10 μL fungi in suspension was allowed to directly contact the sealers, which were freshly mixed or allowed to set for 1 or 7 days. Fresh media was then added and survival of fungi was determined by using 10-fold serial dilution and inoculated onto agar plates. After incubation for 48 h, colony-forming units (CFU) were calculated and their log10 values converted. The data were analyzed using ANOVA and Tukey tests (α = 0.05).
  
  
  RESULTS
  Freshly mixed AH Plus Jet totally inhibited the growth of fungi and showed the highest antifungal activity. GuttaFlow did not show any significant antifungal activity at all times. Freshly mixed iRoot SP and MTA Fillapex were found to be antifungal. Statistical differences were found between freshly mixed and set samples (p < 0.05) in favor of the former, except GuttaFlow. No statistically significant differences were found among the tested sealers at the 1 and 7-day samples (p > 0.05).
  
  
  CONCLUSIONS
  Fresh AH Plus Jet had very potent antifungal activity. All sealers, except GuttaFlow, exhibited antifungal activity when freshly mixed.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Selçuk University , Konya , Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Ozcan
authors.forename: Erkan
authors.initials: E
authors.lastname: Yula
authors.forename: Zeki
authors.initials: Z
authors.lastname: Arslanoğlu
authors.forename: Melek
authors.initials: M
authors.lastname: Inci
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D015169:Colony Count, Microbial; D006801:Humans; D012387:Root Canal Filling Materials / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D012387:Root Canal Filling Materials