title: Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.
abstract: Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. A brief review of the literature is also presented.
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, India.
authors.forename: K C
authors.initials: KC
authors.lastname: Lakshmaiah
authors.forename: B K
authors.initials: BK
authors.lastname: Viveka
authors.forename: N
authors.initials: N
authors.lastname: Anil Kumar
authors.forename: Monika L
authors.initials: ML
authors.lastname: Saini
authors.forename: Sanjib
authors.initials: S
authors.lastname: Sinha
authors.forename: Kamal S
authors.initials: KS
authors.lastname: Saini
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D020699:Gastroscopes; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000627:therapeutic use; D000069283:Rituximab; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Auto-immune antibodies; Diffuse large B-cell lymphoma; Gastric lymphoma; Paraneoplastic cerebellar degeneration; Paraneoplastic neurological disorders; Rituximab