title: Development of a regioselective N-methylation of (benz)imidazoles providing the more sterically hindered isomer.
abstract: An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Emilie
authors.initials: E
authors.lastname: Van Den Berge
authors.forename: Raphaël
authors.initials: R
authors.lastname: Robiette
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001562:Benzimidazoles; C031000:benzimidazole