title: Loss of amino acids into dialysate during hemodialysis using hydrophilic and nonhydrophilic polyester-polymer alloy and polyacrylonitrile membrane dialyzers.
abstract: During hemodialysis, amino acid loss through the dialysate remained a significant problem and was not clear in some dialyzers; therefore, we investigated amino acid loss with hydrophilic and nonhydrophilic polyester-polymer alloy membranes and polyacrylonitrile membranes. Nine maintenance hemodialysis patients were studied to assess amino acid loss during hemodialysis with the three membranes. Total amino acid losses were 85.7 ± 27.2 mg/L, 83.3 ± 16.1 mg/L, and 72.1 ± 22.5 mg/L with the hydrophilic, nonhydrophilic polyester-polymer alloy, and polyacrylonitrile membranes, respectively. Amino acid losses were greater with the hydrophilic membrane compared with the polyacrylonitrile membrane for ornithine (2.0 ± 0.6 vs. 1.4 ± 0.4 mg/L, P = 0.025), phenylalanine (2.4 ± 0.9 vs. 1.8 ± 0.8 mg/L, P = 0.012), and tryptophan (0.6 ± 0.2 vs. 0.4 ± 0.2 mg/L, P = 0.023). Amino acid losses were greater with the nonhydrophilic membrane than with the polyacrylonitrile membrane for ornithine (2.0 ± 0.4 vs. 1.4 ± 0.4 mg/L, P = 0.017), phenylalanine (2.3 ± 0.5 vs. 1.8 ± 0.8 mg/L, P = 0.018), tryptophan (0.7 ± 0.2 vs. 0.4 ± 0.2 mg/L, P = 0.003), and cystine (3.2 ± 0.7 vs. 2.0 ± 0.7 mg/L, P = 0.005). In conclusion, greater losses of ornithine, phenylalanine, tryptophan, and cystine were observed with polyester-polymer alloy than with polyacrylonitrile membranes during hemodialysis. Constant attention should be paid to the amino acid loss profile to improve nutritional control in hemodialysis patients.
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Yokomatsu
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fujikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Toya
authors.forename: Midori
authors.initials: M
authors.lastname: Shino-Kakimoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Itoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsuhashi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hirawa
authors.forename: Gen
authors.initials: G
authors.lastname: Yasuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys; D000596:Amino Acids / Q000378:metabolism*; D015314:Dialysis Solutions / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D006435:Renal Dialysis
chemical_list: D000180:Acrylic Resins; D000497:Alloys; D000596:Amino Acids; D015314:Dialysis Solutions; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; C010504:polyacrylonitrile
keywords: Amino acid loss; Hemodialysis; Polyacrylonitrile membrane; Polyester-polymer alloy membrane