title: Differential impact of cumulative SES risk on methylation of protein-protein interaction pathways as a function of SLC6A4 genetic variation in African American young adults.
abstract: Exposure to cumulative SES risk in childhood may interact with variability at the serotonin transporter linked polymorphic region (5HTTLPR) to alter DNA methylation across interacting sets of proteins. DNA was obtained from 388 African Americans at age 19. Genotype at the 5HTTLPR was determined, and methylation ratios for C-phosphate-G (CpG) residues were assessed. Exposure to cumulative SES risk was determined using repeated parental reports at ages 11-13. At high SES risk, CpG methylation patterns indicated altered cellular stress response in women, but not men, who carried a short allele at the 5HTTLPR. These changes in methylation patterns may lead to increases in mental and physical health risks. No genotype effect emerged for either women or men at low SES risk. Methylation patterns provide guidance in identifying pathways by which genetic susceptibility is transformed into adverse outcomes years later.
authors.affiliation: Owens Institute for Behavioral Research, Center for Family Research, University of Georgia, United States. Electronic address: srhbeach@uga.edu.
authors.forename: Steven R H
authors.initials: SR
authors.lastname: Beach
authors.affiliation: Department of Psychiatry, University of Iowa, United States.
authors.forename: Meeshanthini V
authors.initials: MV
authors.lastname: Dogan
authors.affiliation: Owens Institute for Behavioral Research, Center for Family Research, University of Georgia, United States.
authors.forename: Gene H
authors.initials: GH
authors.lastname: Brody
authors.affiliation: Department of Psychiatry, University of Iowa, United States.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Philibert
mesh_terms: D001741:Black or African American / Q000235:genetics / Q000523:psychology; D017028:Caregivers / Q000523:psychology; D019175:DNA Methylation; D005260:Female; D005500:Follow-Up Studies; D059647:Gene-Environment Interaction; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D060066:Protein Interaction Maps / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000208:ethnology / Q000209:etiology / Q000235:genetics; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5HTTLPR; Gene×environment interaction; Health; Resources; Susceptibility