title: Cardiogenic shock.
abstract: Cardiogenic shock (CS) is a condition in which a marked reduction in cardiac output and inadequate end-organ perfusion results from an array of cardiac insults, the most common of which is acute myocardial infarction. CS is a systemic disease involving a vicious cycle of inflammation, ischemia, and progressive myocardial dysfunction, which often results in death. This life-threatening emergency requires intensive monitoring accompanied by aggressive hemodynamic support; other therapies are tailored to the specific pathophysiology. The development of novel therapeutic strategies is urgently required to reduce the unacceptably high mortality rates currently associated with CS.
authors.affiliation: Coronary Care Unit, Medstar Heart Institute, Medstar Washington Hospital Center, 110 Irving Street Northwest, Suite NA-1103, Washington, DC 20010, USA. Electronic address: howard.a.cooper@medstar.net.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Cooper
authors.forename: Julio A
authors.initials: JA
authors.lastname: Panza
mesh_terms: D001243:Assisted Circulation / Q000379:methods; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003325:Coronary Care Units; D015199:Extracorporeal Membrane Oxygenation; D006342:Heart Rupture, Post-Infarction / Q000175:diagnosis / Q000601:surgery; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D009204:Myocardial Revascularization / Q000379:methods; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000628:therapy
chemical_list: D002317:Cardiovascular Agents
keywords: Acute myocardial infarction; Cardiogenic shock; Extracorporeal membrane oxygenation; Inflammation; Intra-aortic balloon pump; Left ventricular assist device; Prognosis; Reperfusion