title: 2 L versus 4 L of PEG3350 + electrolytes for outpatient colonic preparation: a randomized, controlled trial.
abstract: BACKGROUND
  Low-volume bowel preparations are ideal to ensure patient compliance, thus enabling high-quality examinations to be achieved.
  
  
  OBJECTIVE
  To examine the bowel-cleansing efficacy and patient tolerability of split-dose 2 L PEG3350 + electrolytes (PEG3350e) with 15 mg bisacodyl versus split-dose 4 L PEG3350e.
  
  
  METHODS
  Single-blinded, noninferiority, randomized, controlled trial.
  
  
  METHODS
  Single site, university-affiliated tertiary care center.
  
  
  METHODS
  A total of 325 consecutive patients undergoing elective outpatient colonoscopy.
  
  
  METHODS
  2 L of PEG3350e with 15 mg bisacodyl versus 4 L of PEG3350e, both given in a split-dose fashion.
  
  
  METHODS
  Efficacy and tolerability of a split dose of 2 L of PEG3350e with 15 mg bisacodyl. Efficacy was assessed by using the Boston Bowel Preparation Scale and Ottawa Bowel Preparation Scale. Patient satisfaction and tolerability were assessed by using a short survey.
  
  
  RESULTS
  A total of 325 patients were included in the intention-to-treat analysis (51% male) with a mean ± standard deviation age of 56 ± 11.2 years. No statistically significant difference in cleanliness was found by using the Boston Bowel Preparation Scale (intention-to-treat, P = .381; per-protocol, P = .387) and the Ottawa Bowel Preparation Scale (intention-to-treat, P = .285; per-protocol, P = .334). Participants receiving 2 L of PEG3350e found the preparation easy to consume and were willing to repeat the procedure more often than the 4-L group (P < .001).
  
  
  CONCLUSIONS
  Single-center study looking at outpatient colonoscopies; unable to comment on adenoma detection rate.
  
  
  CONCLUSIONS
  Bowel-cleansing efficacy was similar in both the 2-L and 4-L PEG3350e groups; however, patient tolerability and willingness to repeat preparation were statistically greater with the 2 L of PEG3350e with 15 mg bisacodyl regimen.
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Mayur
authors.initials: M
authors.lastname: Brahmania
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Ou
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Brian
authors.initials: B
authors.lastname: Bressler
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Hin Kin
authors.initials: HK
authors.lastname: Ko
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Lam
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Telford
authors.affiliation: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Enns
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001726:Bisacodyl / Q000008:administration & dosage; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003113:Colonoscopy / Q000379:methods*; D004573:Electrolytes / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D002400:Cathartics; D004573:Electrolytes; D001726:Bisacodyl; D011092:Polyethylene Glycols