title: [Intraductal papillary neoplasms of the bile duct (IPNB). Diagnostic criteria, carcinogenesis and differential diagnostics].
abstract: Intraductal papillary neoplasms of the bile duct (IPNB) are rare precursor lesions of intrahepatic and extrahepatic cholangiocarcinoma that follow an adenoma-carcinoma sequence. According to the histomorphology and the distinct immunohistochemical mucin pattern, four different subtypes are recognized: pancreatobiliary, intestinal, gastric and oncocytic. Differential diagnoses include micropapillary lesions (biliary intraepithelial neoplasms), papillary cystic lesions (intraductal tubulopapillary neoplasms) and cystic lesions (mucinous cystic neoplasms).
authors.affiliation: Institut für Allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675, München, Deutschland.
authors.forename: A M
authors.initials: AM
authors.lastname: Schlitter
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
authors.forename: I
authors.initials: I
authors.lastname: Esposito
mesh_terms: D001650:Bile Duct Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D021441:Carcinoma, Pancreatic Ductal / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D002291:Carcinoma, Papillary / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000032:analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010179:Pancreas / Q000473:pathology; D011230:Precancerous Conditions / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D009626:Terminology as Topic; D014944:World Health Organization
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins