title: Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report.
abstract: Gonadoblastoma is a rare gonadal tumour consisting of a mixture of germ cells and sex cord stromal derivatives resembling immature granulosa and Sertoli cells. It usually arises in various types of gonadal dysgenesis containing Y chromosome like pure or mixed gonadal dysgenesis. Occurrence in phenotypically and chromosomally normal women is very rare. We report here a case of gonadoblastoma with dysgerminoma in a 14-years-old girl who presented with a huge tumour, virilisation and normal 46XX karyotype. Association of dysgerminoma is seen in 50% cases of gonadoblastomas. Elevated tumour markers like hCG and alpha Fetoprotein may make the diagnosis challenging.
authors.affiliation: Associate Professor, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy .
authors.forename: Deepa V
authors.initials: DV
authors.lastname: Kanagal
authors.forename: Kishan
authors.initials: K
authors.lastname: Prasad
authors.forename: Aparna
authors.initials: A
authors.lastname: Rajesh
authors.forename: Rohan G
authors.initials: RG
authors.lastname: Kumar
authors.forename: Sara
authors.initials: S
authors.lastname: Cherian
authors.forename: Harish
authors.initials: H
authors.lastname: Shetty
authors.forename: Prasanna Kumar
authors.initials: PK
authors.lastname: Shetty
keywords: 46XX Karyotype; Dysgerminoma; Gonadoblastoma; Tumour