title: Time recall; future concept of chronomodulating chemotherapy for cancer.
abstract: The human metabolism is regulated by our internal clock; the circadian rhythm (24h-25h). There are several factors included in the regulatory pathway such as; genes (PER1-3), (CRY1-2), TIM hormones (cortisol, catecholamines, melatonin and insulin) drugs, enzymes, sleep disorders and diseases. Each one contributes in a different degree and in order to enhance the therapeutic result; we should include these factors into clusters instead of targeting each factor one by one. Malignances deregulate gene-protein expression/production, enzyme production, and in addition they induce fatigue, insomnia, stress and sleep disorders. All these factors finally contribute in minimizing the efficiency of chemotherapy treatment and quality of life. In addition, the circadian rhythm disruption induces tumor genesis, stress, and downregulates the defense and repair mechanisms of the human body. In the current mini review the underlying mechanism of the circadian rhythm is provided, along with the influence of sleep disturbances in cancer patient therapy. A proposal is presented to divide circadian rhythm and sleep disturbances into two major clusters with different management, however; with a common target to improve treatment efficiency and quality of life. Finally, a chrono-chemotherapy administration model is proposed in order to have less chemotherapy side effects.
authors.affiliation: Pulmonary Department, G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki. Thessaloniki, Greece. pzarog@hotmail.com.
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.forename: Kaid
authors.initials: K
authors.lastname: Darwiche
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.forename: Dionysis
authors.initials: D
authors.lastname: Spyratos
authors.forename: Lonny
authors.initials: L
authors.lastname: Yarmus
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Stylianos
authors.initials: S
authors.lastname: Kakolyris
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrigos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zarogoulidis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002940:Circadian Rhythm; D055870:Drug Chronotherapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D012893:Sleep Wake Disorders
chemical_list: D000970:Antineoplastic Agents