title: A jack of all trades to combat drug-resistant Gram-negative bacteria.
abstract: In this issue of Chemistry & Biology, Jahnsen and colleagues describe a multimodal mechanism of action of an unusual peptide-peptoid hybrid with broad-spectrum antibacterial activity. They demonstrate that the molecule has effects on many aspects of bacterial metabolism and also modulates host immune responses.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA; Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: kodadek@scripps.edu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kodadek
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D057786:Peptidomimetics / Q000378:metabolism* / Q000494:pharmacology*; D059748:Proteolysis
chemical_list: D000890:Anti-Infective Agents; D057786:Peptidomimetics