title: Targeting mitochondrial DNA with a platinum-based anticancer agent.
abstract: An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada.
authors.forename: Simon P
authors.initials: SP
authors.lastname: Wisnovsky
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Wilson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Radford
authors.forename: Mark P
authors.initials: MP
authors.lastname: Pereira
authors.forename: Maria R
authors.initials: MR
authors.lastname: Chan
authors.forename: Rebecca R
authors.initials: RR
authors.lastname: Laposa
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
authors.forename: Shana O
authors.initials: SO
authors.lastname: Kelley
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D004272:DNA, Mitochondrial / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004272:DNA, Mitochondrial; D002945:Cisplatin