title: Quality of life following completion of treatment for adult acute lymphoblastic leukemia with a pediatric-based protocol.
abstract: Using multiple validated self-report instruments, we evaluated the health-related quality of life (HRQoL) of 29 adult ALL patients a median of 28 months after completing a pediatric-based treatment regimen. Global health was similar to normative data, but leukemia survivors had lower cognitive and social function, and reported more financial difficulty. Fatigue and pain affected 83% and 53% of patients, respectively, and both showed significant inverse correlation with overall health and all functional scales. Vincristine-related peripheral neuropathy was reported by 43%. Although therapy-related symptoms were persistent, long-term ALL survivors have a global HRQoL similar to the general population.
authors.affiliation: Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Elena
authors.initials: E
authors.lastname: Liew
authors.forename: Santhosh
authors.initials: S
authors.lastname: Thyagu
authors.forename: Eshetu G
authors.initials: EG
authors.lastname: Atenafu
authors.forename: Shabbir M H
authors.initials: SM
authors.lastname: Alibhai
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Brandwein
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000523:psychology / Q000534:rehabilitation*; D011788:Quality of Life; D012074:Remission Induction; D057566:Self Report; D017741:Survivors / Q000523:psychology* / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Acute lymphoblastic leukemia; Chemotherapy; Leukemia; Quality of life