title: Triglyceride screening may improve cardiometabolic disease risk assessment in Latinos with poorly controlled type 2 diabetes.
abstract: To characterize metabolic syndrome (MetS) prevalence and cardiometabolic risk, HbA1c, fasting plasma glucose (FPG), plasma lipids, blood pressure, BMI, and waist circumference were measured in 211 Latino adults with type 2 diabetes. Participants were obese (BMI=33.7±7.8 kg/m2) and had poor glycemic control (HbA1c=9.6±1.8 %; FPG=190±85 mg/dL), but normal LDL and HDL cholesterol concentrations (98±38 mg/dL, and 52±14 mg/dL, respectively). Relative to the lowest, participants in the highest quintile of plasma triglycierides had higher total cholesterol (23%; p&lt;.0001), FPG (47%; p&lt;.0001), systolic blood pressure (3%; p&lt;.05) and diastolic blood pressure (6%; p&lt;.05), and lower HDL cholesterol (23%; p&lt;.01). Comparable relationships were observed in an age-adjusted regression model. Framingham risk was equivalent to 9.4±6.4% and 12.2±9.6% 10-year CHD risk in men and women, respectively (p&lt;.05). Cardiometabolic risk in this population is associated with a high prevalence of the MetS despite the relatively low cholesterol concentrations. Triglyceride screening may help identify individuals at higher risk.
authors.forename: Sonia
authors.initials: S
authors.lastname: Vega-López
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Calle
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Fernandez
authors.forename: Grace
authors.initials: G
authors.lastname: Kollannoor-Samuel
authors.forename: Jyoti
authors.initials: J
authors.lastname: Chhabra
authors.forename: Michael
authors.initials: M
authors.lastname: Todd
authors.forename: Sofia
authors.initials: S
authors.lastname: Segura-Pérez
authors.forename: Darrin
authors.initials: D
authors.lastname: D'Agostino
authors.forename: Grace
authors.initials: G
authors.lastname: Damio
authors.forename: Rafael
authors.initials: R
authors.lastname: Pérez-Escamilla
mesh_terms: D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003237:Connecticut; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D014505:Urban Population
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human