title: Individual-specific tonometry on porcine eyes.
abstract: Intraocular pressure (IOP) monitoring is important in the diagnosis and management of glaucoma. The measurement of IOP is affected by corneal properties, but the effect of corneal stiffness on IOP measurement is unaccounted for in pressure measurement instruments such as the Goldmann Applanation Tonometer (GAT). A new instrumented non-invasive indentation tonometry that can measure IOPIST, a corneal stiffness-corrected intraocular pressure is developed. The inter-individual corneal variations of 12 porcine eyes ex vivo were independently characterized; and their true intraocular pressure, IOPT's, were set using a manometer before indentation using the new indentation tonometry. Analyses of the load-displacement data showed that porcine corneal stiffness varied more than five times from 0.045 to 0.253N/mm. Analysis showed that, without individual stiffness correction, inter-individual variation of IOPGAT can vary up to 8mmHg from IOPT at 15mmHg; the error becomes larger at high IOPT. In comparison when corneal stiffness is accounted for, IOPIST has a significantly smaller error of 1.82±1.70mmHg for IOPT between 12 and 40mmHg than IOPGAT. The results showed that the new tonometry successfully accounted for inter-individual variations in IOP measurement.
authors.affiliation: The Department of Mechanical Engineering, The Hong Kong University of Science and Technology, Hong Kong. Electronic address: leoleung@ust.hk.
authors.forename: Leo K K
authors.initials: LK
authors.lastname: Leung
authors.affiliation: The Department of Mechanical Engineering, The Hong Kong University of Science and Technology, Hong Kong. Electronic address: matchko@ust.hk.
authors.forename: Match W L
authors.initials: MW
authors.lastname: Ko
authors.affiliation: The Department of Mechanical Engineering, The Hong Kong University of Science and Technology, Hong Kong. Electronic address: david.lam@ust.hk.
authors.forename: David C C
authors.initials: DC
authors.lastname: Lam
mesh_terms: D000818:Animals; D003315:Cornea / Q000502:physiology; D007429:Intraocular Pressure; D057285:Precision Medicine; D013552:Swine; D014065:Tonometry, Ocular / Q000379:methods*
keywords: Biomechanics; Cornea; Glaucoma; Intraocular pressure; Stiffness; Tonometry