title: Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation.
abstract: Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Oktay
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yersal
authors.forename: Nezih
authors.initials: N
authors.lastname: Meydan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sağıroğlu
authors.forename: Omer
authors.initials: O
authors.lastname: Uyanık
authors.forename: Sabri
authors.initials: S
authors.lastname: Barutca