title: Aberrant expression of multiple T antigens: CD4, CD5, and CD8 on diffuse large B-cell lymphoma.
abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Aberrant expression of T antigens (exclusive of CD5) in DLBCL has been described in the literature; however, coexpression of 2 or more T antigens is rare. We report a case with a well-established diagnosis of DLBCL, coexpressing 3 T-cell antigens, CD4, CD5, and CD8. Although the clinical significance of T antigen coexpression in DLBCL is unclear, it is important to be aware of such phenotypic plasticity to ensure accurate diagnoses are made. The expression of multiple T-cell antigens may introduce diagnostic confusion and make subclassification of a lymphoma using World Health Organization criteria difficult.
authors.affiliation: *Department of Pathology, Division of Hematopathology, University of Utah Health Sciences Center †ARUP Laboratories Inc., Salt Lake City, UT.
authors.forename: Nikhil A
authors.initials: NA
authors.lastname: Sangle
authors.forename: Rodney R
authors.initials: RR
authors.lastname: Miles
authors.forename: Todd W
authors.initials: TW
authors.lastname: Kelley
authors.forename: Sherrie L
authors.initials: SL
authors.lastname: Perkins
mesh_terms: D000369:Aged, 80 and over; D015704:CD4 Antigens / Q000378:metabolism*; D018956:CD5 Antigens / Q000378:metabolism*; D016827:CD8 Antigens / Q000378:metabolism*; D002999:Clone Cells; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000378:metabolism; D014944:World Health Organization
chemical_list: D015704:CD4 Antigens; D018956:CD5 Antigens; D016827:CD8 Antigens