title: [Preparation of valsartan nanosuspensions and its in vitro dissolution].
abstract: To increase the dissolution rate and extent of valsartan, valsartan nanosuspensions have been prepared. Controlled precipitation assisted with sonication is utilized to prepare valsartan nanosuspensions, the concentration of the drug, stabilizer and costablizer had a great effect on the stability of the preparation according to the pre-experiment. So the method of central composite design-response surface is used to optimize the prescription based on the above three factors and the particle size as the response value. The software Origin 8.0 is used to draw the view of the three-dimensional effects and 2D contour map, to get the optimal prescription area. Valsartan nanosuspensions were prepared. The mean diameter and zeta potential are about 216.6 nm and -57.7 mV, respectively. Compared with the microsuspensions and commercial preparation, the dissolution of valsartan nanosuspensions was faster and the bioavailability can be enhanced to some extent.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Song
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Guo
authors.forename: Wei-San
authors.initials: WS
authors.lastname: Pan
authors.forename: Xing-Gang
authors.initials: XG
authors.lastname: Yang
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000737:chemistry*; D001682:Biological Availability; D011232:Chemical Precipitation; D004355:Drug Stability; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012107:Research Design; D012995:Solubility; D013535:Suspensions; D014465:Ultrasonics / Q000379:methods; D000068756:Valsartan / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D013535:Suspensions; D000068756:Valsartan