title: Correlation between CD14+CD16++ monocytes in peripheral blood and hypertriglyceridemia after allograft renal transplantation.
abstract: BACKGROUND
  Cardio-cerebrovascular diseases are key factors causing recipient the death after kidney transplantation (KT). Hypertriglyceridemia (HTG), a complication commonly occurring among KT patients, is a major risk factor for cardio-cerebrovascular diseases. The objective of this study was to examine the correlation between peripheral CD14+CD16++ monocytes in KT patients and blood lipids as well as factors affecting hyperglycemia, seeking to understand mechanisms of inflammatory immune reactions.
  
  
  METHODS
  KT patients (n = 60) were divided into subjects with HTG (n = 35) versus without HTG (n = 25). A cohort of healthy participants (55 cases) was divided into the cases without (n = 30) versus with HTG (n = 25). The proportion of peripheral CD14+CD16 ++ monocytes was determined using flow cytometry and hematology, and biochemical indicators were measured by conventional methods. We correlated HTG with these indicators.
  
  
  RESULTS
  The proportion of peripheral blood CD14+CD16++ monocytes among the renal transplant group was significantly lower (P < .05) than that of normal controls. The expression of CD14+CD16++ monocytes among transplant recipients positively correlated with triglycerides (R = 0.449 and R = 0.008, respectively).
  
  
  CONCLUSIONS
  CD14+CD16++ mononcytes in peripheral blood may represent an independent risk factor for HTG after KT.
authors.affiliation: Department of Urology, Third Affiliated Hospital, Suzhou University, Changzhou, China, and Lund Universities, Lund, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Xue
authors.forename: X
authors.initials: X
authors.lastname: He
authors.forename: C
authors.initials: C
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: N
authors.initials: N
authors.lastname: Xu
mesh_terms: D000328:Adult; D005260:Female; D058851:GPI-Linked Proteins / Q000276:immunology; D006801:Humans; D015228:Hypertriglyceridemia / Q000276:immunology*; D016030:Kidney Transplantation; D018950:Lipopolysaccharide Receptors / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG