title: Synthesis of graphene oxide based CuO nanoparticles composite electrode for highly enhanced nonenzymatic glucose detection.
abstract: CuO nanoparticles (NPs) based graphene oxide (CuO/GO) composites with different CuO NPs loading amount as well as pure CuO NPs with different hydrothermal temperatures were synthesized using a hydrothermal method. Transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Raman spectroscopy were employed to characterize the morphology and structures of our samples. The influence of hydrothermal temperature, GO sheet, and loading amount of CuO on particle size and structure of CuO was systemically investigated. The nonenzymatic biosensing properties of CuO/GO composites and CuO NPs toward glucose were studied based on glassy carbon electrode (GCE). The sensing properties of CuO NPs were improved after loading on GO sheets. The CuO/GO composites with saturated loading of the CuO NPs exhibited the best nonenzymatic biosensing behavior. It exhibited a sensitivity of 262.52 μA mM(-1) cm(-2) to glucose with a 0.69 μM detection limit (S/N = 3) and a linear range from 2.79 μM to 2.03 mM under a working potential of +0.7 V. It also showed outstanding long term stability, good reproducibility, excellent selectivity, and accurate measurement in real serum sample. It is believed that CuO/GO composites show good promise for further application on nonenzymatic glucose biosensors.
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University , 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Chunyang
authors.initials: C
authors.lastname: Zhou
authors.forename: Ruiqing
authors.initials: R
authors.lastname: Xing
authors.forename: Qilin
authors.initials: Q
authors.lastname: Dai
authors.forename: Dali
authors.initials: D
authors.lastname: Liu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D005947:Glucose / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D013696:Temperature
chemical_list: D001786:Blood Glucose; D010087:Oxides; D006108:Graphite; D003300:Copper; D005947:Glucose; C030973:cupric oxide