title: Evaluation of escitalopram, sertraline, and methylphenidate in the immature rat uterotrophic assay.
abstract: Psychotropics are among the most prescribed medications. There are indications in the literature that fluoxetine (FLX; selective serotonin reuptake inhibitor [SSRI] antidepressant) and methylphenidate (MPH) could have a hormonal mode of action. This study was designed to evaluate the immature rat uterotrophic assay Substitute by (1) if sertraline (SER) and escitalopram (ESC) 2 other SSRI antidepressants would share the estrogenicity described for FLX and (2) MPH for estrogenicity and antiestrogenicity. The 18-day-old Wistar rats with were divided into olive oil, estradiol (0.3 mg/kg), estradiol + tamoxifen (10 mg/kg), SER (5, 15, or 45 mg/kg), ESC (2, 6, or 18 mg/kg), MPH (2.5 or 5 mg/kg), and estradiol + MPH groups. As expected, estradiol increased the weight of uterus, and this effect was counterbalanced by concomitant treatment with tamoxifen. The SER, ESC, and MPH had no effect on the uterus weight. The results suggest that ESC and SER do not share the estrogenicity described for FLX and that MPH does not disrupt estrogenic signaling.
authors.affiliation: Departamento de Ciências Fisiológicas, CCB, UEL, CEP 86051-980 Londrina, Paraná, Brazil. Email: egmoreira@uel.br.
authors.forename: Bruno Garcia
authors.initials: BG
authors.lastname: Montagnini
authors.forename: Simone
authors.initials: S
authors.lastname: Bortolan
authors.forename: Bárbara Daiane
authors.initials: BD
authors.lastname: dos Santos
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Moreno
authors.forename: Nathália de Azevedo
authors.initials: Nde A
authors.lastname: Camin
authors.forename: Daniela Cristina Ceccatto
authors.initials: DC
authors.lastname: Gerardin
authors.forename: Estefânia Gastaldello
authors.initials: EG
authors.lastname: Moreira
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology*; D005260:Female; D008774:Methylphenidate / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000928:Antidepressive Agents; D015283:Citalopram; D008774:Methylphenidate; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline
keywords: endocrine; escitalopram; methylphenidate; sertraline; uterotrophic assay