title: Phytochemical Compositions and Antioxidant and Anti-Inflammatory Activities of Crude Extracts from Ficus pandurata H. (Moraceae).
abstract: Background. Ficus pandurata H. (Moraceae) is widely used in traditional Chinese medicine as a healthy food condiment or a medicine for treatment of various diseases including inflammation. Objective. The purpose of the present study is to investigate the phytochemical compositions and antioxidant and anti-inflammatory activities of crude water (FPW) and ethanolic extracts (FPE) from Ficus pandurata H. Methods. Phytochemical compositions were identified by a high-performance liquid chromatography-electrospray ionization-mass spectrometry method (HPLC-ESI-MS). The antioxidant activities were evaluated by diphenylpicrylhydrazyl (DPPH) and hydroxyl radical assays, and the anti-inflammatory activities were evaluated by paw edema and levels of inflammatory mediator TNF- α and PGE2 in monosodium urate (MSU) crystal-induced rats. Results. Six compounds were identified by HPLC-MS method, and abundance of phenolics was found in FPE. The FPE showed concentration-dependent-significant scavenging of DPPH and hydroxyl radicals with IC50 values 118.4 and 192.9  μ g/mL, respectively. The FPE treatment significantly inhibited the paw edema and the production of TNF- α and PGE2 in MSU crystal-induced rats. Conclusion. The FPE exerted stronger antioxidant and anti-inflammatory activities which may be attributed to its high phenolic content.
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Lv
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuezhi
authors.initials: X
authors.lastname: Chen
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Xie
authors.forename: Changfeng
authors.initials: C
authors.lastname: Hu
authors.forename: Chengping
authors.initials: C
authors.lastname: Wen
authors.forename: Kezhi
authors.initials: K
authors.lastname: Jiang