title: Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress.
abstract: Coxsackievirus A16 (CA16) infection, which is responsible for hand, foot and mouth disease (HFMD), has become a common health problem in Asia due to the prevalence of the virus. Thus, it is important to understand the pathogenesis of CA16 infection. Viruses that induce endoplasmic reticulum (ER) stress are confronted with the unfolded protein response (UPR), which may lead to apoptotic cell death and influence viral replication. In this study, we found that CA16 infection could induce apoptosis and ER stress in RD cells. Interestingly, apoptosis via the activation of caspase-3, -8 and -9 in the extrinsic or intrinsic apoptotic pathways in RD cells was inhibited by 4-phenyl butyric acid (4PBA), a chemical chaperone that reduces ER stress. These results suggest that CA16 infection leads to ER stress, which in turn results in prolonged ER stress-induced apoptosis. This study provides a new basis for understanding CA16 infection and host responses.
authors.affiliation: Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Guoguo
authors.initials: G
authors.lastname: Zhu
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Lianglu
authors.initials: L
authors.lastname: Zhang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Shi
authors.forename: Wenhua
authors.initials: W
authors.lastname: Li
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Liu
authors.forename: Biwen
authors.initials: B
authors.lastname: Peng
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Wanhong
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: He
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D059865:Endoplasmic Reticulum Stress; D004770:Enterovirus; D006232:Hand, Foot and Mouth Disease / Q000473:pathology* / Q000821:virology*; D006801:Humans
keywords: Apoptosis; Caspases; Coxsackievirus A16; ER stress