title: The role of mitochondrial dysfunction in sepsis-induced multi-organ failure.
abstract: An important role for bioenergetic dysfunction is increasingly emerging to potentially explain the paradox of clinical and biochemical organ failure in sepsis yet minimal cell death, maintained tissue oxygenation and recovery in survivors. Associations are well-recognized between the degree of mitochondrial dysfunction and outcomes. While this does not confirm cause-and-effect, it does nevertheless suggest a new route for therapeutic intervention focused on either mitochondrial protection or acceleration of the recovery process through stimulation of mitochondrial biogenesis (new protein turnover). This is particularly pertinent in light of the multiple trial failures related to immunomodulatory therapies. This overview will provide insights into mitochondrial biology, the relevance to sepsis, and therapeutic opportunities that possibly emerge.
authors.affiliation: Bloomsbury Institute of Intensive Care Medicine; University College London; London, UK.
authors.forename: Mervyn
authors.initials: M
authors.lastname: Singer
mesh_terms: D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000276:immunology / Q000473:pathology*; D063306:Mitophagy; D009102:Multiple Organ Failure / Q000503:physiopathology*; D009569:Nitric Oxide / Q000096:biosynthesis; D018805:Sepsis / Q000276:immunology* / Q000503:physiopathology*; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology / Q000628:therapy
chemical_list: D009569:Nitric Oxide
keywords: biogenesis; mitochondria; mitophagy; multi-organ failure; nitric oxide; reactive oxygen species; sepsis