title: Differential anticancer drug delivery with a nanogel sensitive to bacteria-accumulated tumor artificial environment.
abstract: Differential anticancer drug delivery that selectively releases a drug within a tumor represents an ideal cancer therapy strategy. Herein, we report differential drug delivery to the tumor through the fabrication of a special bacteria-accumulated tumor environment that responds to bacteria-sensitive triple-layered nanogel (TLN). We demonstrate that the attenuated bacteria SBY1 selectively accumulated in tumors and were rapidly cleared from normal tissues after intravenous administration, leading to a unique bacteria-accumulated tumor environment. Subsequent administrated doxorubicin-loaded TLN (TLND) was thus selectively degraded in the bacteria-accumulated tumor environment after its accumulation in tumors, triggering differential doxorubicin release and selectively killing tumor cells. This concept can be extended and improved by using other factors secreted by bacteria or materials to fabricate a unique tumor environment for differential drug delivery, showing potential applications in drug delivery.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, and Department of Polymer Science and Engineering, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Xiong
authors.forename: Yan
authors.initials: Y
authors.lastname: Bao
authors.forename: Xiao-Jiao
authors.initials: XJ
authors.lastname: Du
authors.forename: Zi-Bin
authors.initials: ZB
authors.lastname: Tan
authors.forename: Qiu
authors.initials: Q
authors.lastname: Jiang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Wang
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000378:metabolism; D016956:Burkholderia cepacia / Q000378:metabolism; D002460:Cell Line; D045744:Cell Line, Tumor; D004317:Doxorubicin; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D049452:Green Fluorescent Proteins / Q000737:chemistry; D006801:Humans; D007262:Infusions, Intravenous; D008049:Lipase / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D050997:Nanomedicine; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D049452:Green Fluorescent Proteins; D004317:Doxorubicin; D008049:Lipase; D000469:Alkaline Phosphatase