title: [Traumatic brain injury and anterior pituitary dysfunction. Regarding 33 cases: Evolution profile over a six-month period].
abstract: OBJECTIVE
  To measure anterior pituitary dysfunction in traumatic brain injury (TBI) and assess the correlations between this disorder, clinical signs and brain lesions.
  
  
  METHODS
  This was a prospective, longitudinal and analytic study conducted in the department of neurosurgery at the National Hospital of Niamey and the institute of radioisotopes of Niamey University between November 2009 and November 2010. All patients admitted for head trauma were included in the study. They were followed-up for 6 months and underwent clinical, hormonal and CT scan analysis. The hormonal studies targeted gonadotroph hormone, growth hormone (GH), corticotroph, lactotroph, and thyreotroph axes.
  
  
  RESULTS
  Thirty-three patients were included in the study. The sex ratio was 15.4:1. The mean age was 28.21 years. Glasgow coma scale score was between 7 and 12 in 52% of cases, with brain contusions in 54.5% of cases. In the acute phase, hypogonadism was reported in 64% of cases, and growth hormone deficiency in 58% of cases. Hormonal follow-up at three months showed GH deficiency in 48% of cases with an elevated luteinizing hormone (LH) in 42% of cases. At sixth months, a rise in LH was observed in 55% with GH deficiency in 52% of cases. Surgical procedures were performed in 21% of cases. At 6 months a post-concussion syndrome was observed in 48.48% of cases.
  
  
  CONCLUSIONS
  These pituitary dysfunctions are common and should be investigated into the management of TBI.
authors.affiliation: Service de neurochirurgie, hôpital National, Niamey, Niger. Electronic address: s_sanoussi@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Sanoussi
authors.forename: A
authors.initials: A
authors.lastname: Ali
authors.forename: H
authors.initials: H
authors.lastname: Laouali
authors.forename: I
authors.initials: I
authors.lastname: Assoumane
authors.forename: S
authors.initials: S
authors.lastname: Chaibou Maman
authors.forename: M
authors.initials: M
authors.lastname: Baoua
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006728:Hormones / Q000378:metabolism*; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male; D010900:Pituitary Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D011446:Prospective Studies
chemical_list: D006728:Hormones; D019382:Human Growth Hormone
keywords: Dysfonctionnements endocriniens; Niamey; Niger; Pituitary disturbances; TBI; Traumatismes cranio-encéphaliques