title: Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.
abstract: The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling.
authors.affiliation: Van Andel Research Institute, 333 Bostwick Ave. N.E., Grand Rapids, MI 49503, USA. bart.williams@vai.org.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Valkenburg
authors.forename: Carrie R
authors.initials: CR
authors.lastname: Graveel
authors.forename: Cassandra R
authors.initials: CR
authors.lastname: Zylstra-Diegel
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Zhong
authors.forename: Bart O
authors.initials: BO
authors.lastname: Williams