title: Is the alliance always a predictor of change in psychotherapy for depression?
abstract: OBJECTIVE
  Although without a doubt alliance has a consistent impact on outcome, to date it remains unclear whether alliance directly accounts for symptom change.
  
  
  METHODS
  Using data from a randomized clinical trial, the alliance-outcome timeline was analyzed. The Relationship factor of the Helping Alliance Questionnaire I (measured twice, middle and late during treatment) was used.
  
  
  RESULTS
  Regression and mixed model analyses showed that alliance did not predict subsequent symptom change as measured by the Hamilton Depression Rating Scale beyond prior symptom change and the alliance course was not predicted by early symptom change.
  
  
  CONCLUSIONS
  These results lead to the question whether alliance directly accounts for subsequent change or moderates change via technique, transference phenomena, therapist competences and patient characteristics.
authors.affiliation: a Arkin Mental Health Care , Amsterdam , The Netherlands.
authors.forename: Mariëlle
authors.initials: M
authors.lastname: Hendriksen
authors.forename: Jaap
authors.initials: J
authors.lastname: Peen
authors.forename: Rien
authors.initials: R
authors.lastname: Van
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Barber
authors.forename: Jack
authors.initials: J
authors.lastname: Dekker
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011369:Professional-Patient Relations; D011614:Psychotherapy, Brief / Q000379:methods / Q000592:standards; D064889:Psychotherapy, Psychodynamic / Q000379:methods / Q000592:standards*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome