title: [Evaluation of multidrug-resistant tuberculosis treatment in Ivory Coast from 2008 to 2010].
abstract: This is a retrospective study conducted from January 2008 to December 2010 on sectional descriptive analysis of records of patients treated for MDR-TB and whose follow-up was in the thoracic department of Centre Hospitalier Universitaire (CHU) of Cocody in Abidjan Côte d'Ivoire. We selected eight patients who met the inclusion criteria of 21 MDR-TB patients registered during the study period. The average age was 29.25years ranging from 21 to 39. Males accounted for 75% of the patients (6 males and 2 females). The students represented the professional social layer most affected with 37.5% of the patients. All patients had a history of tuberculosis and only one patient was HIV positive under anti-retroviral (zidovudin, lamivudin and efavirenz). All cultures found Mycobacterium tuberculosis. The resistance profile in addition to isoniazid and rifampicin, found two cases of resistance to ethambutol and streptomycin. The chest radiograph at the time of initiation of second-line treatment showed essentially excavations in 75% of cases and infiltrates in 25%. The lesions were bilateral in 7 of 8 patients (87.5%). The main side effects observed during treatment were limited to cochleovestibular disorders (2 patients) and neuropsychiatric disorders (2 patients) and digestive disorders in half of the patients with removal of the offending molecule kanamycin. After 24months of treatment, it was numbered five cures (62.5%), two failures and one death.
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire. Electronic address: ahuib@hotmail.fr.
authors.forename: B J-M
authors.initials: BJ
authors.lastname: Ahui
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: K
authors.initials: K
authors.lastname: Horo
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: A S
authors.initials: AS
authors.lastname: Bakayoko
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: A B
authors.initials: AB
authors.lastname: Kouassi
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: J C
authors.initials: JC
authors.lastname: Anon
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: V C
authors.initials: VC
authors.lastname: Brou-Gode
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: M O
authors.initials: MO
authors.lastname: Koffi
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: M V
authors.initials: MV
authors.lastname: Itchy
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: A S
authors.initials: AS
authors.lastname: N'Gom
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: N B
authors.initials: NB
authors.lastname: N'Goran
authors.affiliation: Service de pneumologie, CHU de Cocody, Abidjan, Côte d'Ivoire; UFR sciences médicales, Abidjan, Côte d'Ivoire.
authors.forename: E
authors.initials: E
authors.lastname: Aka-Danguy
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D007560:Cote d'Ivoire / Q000453:epidemiology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000628:therapy*; D028761:Withholding Treatment / Q000706:statistics & numerical data; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin
keywords: Multidrug-resistant tuberculosis; Mycobacterium tuberculosis; Tuberculose multi-résistante