title: AU-binding factor 1 expression was correlated with metadherin expression and progression of hepatocellular carcinoma.
abstract: RNA-binding factor 1 (AUF1) was found to be up-regulated in numerous tumors compared with untransformed tissues. Furthermore, it has been identified to regulate mRNAs en masse in hepatocellular carcinoma (HCC). Metadherin (MTDH) as a novel oncogene also promotes tumor progression and metastasis in HCC. Our study aimed to investigate the correlation between AUF1 and MTDH expressions by immunochemistry in 146 HCC patients from Heilongjiang region. AUF1 expression in HCC tumors was higher than that in the matched normal liver tissues. Particularly, AUF1 overexpression was closely associated with tumor size (P < 0.022), TNM stage (P < 0.003), hepatitis B surface antigen status, and AFP serum levels (P < 0.05). Furthermore, AUF1 overexpression led to poor outcome during 5-year follow-up (P < 0.001). Additionally, AUF1 and MTDH expressions were correlated with each other. Our findings suggest that the AUF1 gene may play an important role in HCC progression and be a novel biomarker in the future.
authors.affiliation: Department of Infectious Disease, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
authors.forename: Yingzhuo
authors.initials: Y
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Kang
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Chunlin
authors.initials: C
authors.lastname: Xu
authors.forename: Shimei
authors.initials: S
authors.lastname: Wang
authors.forename: Haiyu
authors.initials: H
authors.lastname: Jin
authors.forename: Yunling
authors.initials: Y
authors.lastname: Li
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Liu
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D000081035:Heterogeneous Nuclear Ribonucleoprotein D0; D034502:Heterogeneous-Nuclear Ribonucleoprotein D / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging; D016601:RNA-Binding Proteins; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C000630986:HNRNPD protein, human; D000081035:Heterogeneous Nuclear Ribonucleoprotein D0; D034502:Heterogeneous-Nuclear Ribonucleoprotein D; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins