title: Gene Expression Profiles at Moxibustioned Site (ST36): A Microarray Analysis.
abstract: As a major alternative therapy in Traditional Chinese Medicine, it has been demonstrated that moxibustion could generate a series of molecular events in blood, spleen, and brain, and so forth. However, what would happen at the moxibustioned site remained unclear. To answer this question, we performed a microarray analysis with skin tissue taken from the moxibustioned site also Zusanli acupoint (ST36) where 15-minute moxibustion stimulation was administrated. The results exhibited 145 upregulated and 72 downregulated genes which responded immediately under physiological conditions, and 255 upregulated and 243 downregulated genes under pathological conditions. Interestingly, most of the pathways and biological processes of the differentially expressed genes (DEGs) under pathological conditions get involved in immunity, while those under physiological conditions are involved in metabolism.
authors.affiliation: Acupuncture & Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China ; Joint Laboratory of Biochip between Chengdu University of Traditional Chinese Medicine and CapitalBio Co. Ltd., 37 Shi-er Qiao Road, Chengdu 610075, China ; Key Laboratory for Acupuncture & Chronobiology of Sichuan Province, Chengdu 610075, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Yin
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.forename: Sheng-Feng
authors.initials: SF
authors.lastname: Lu
authors.forename: Ling
authors.initials: L
authors.lastname: Luo
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Wang
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Liu
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Yu