title: Safety and efficacy of stereotactic body radiation therapy in the treatment of pulmonary metastases from high grade sarcoma.
abstract: Introduction. Patients with high-grade sarcoma (HGS) frequently develop metastatic disease thus limiting their long-term survival. Lung metastases (LM) have historically been treated with surgical resection (metastasectomy). A potential alternative for controlling LM could be stereotactic body radiation therapy (SBRT). We evaluated the outcomes from our institutional experience utilizing SBRT. Methods. Sixteen consecutive patients with LM from HGS were treated with SBRT between 2009 and 2011. Routine radiographic and clinical follow-up was performed. Local failure was defined as CT progression on 2 consecutive scans or growth after initial shrinkage. Radiation pneumonitis and radiation esophagitis were scored using Common Toxicity Criteria (CTC) version 3.0. Results. All 16 patients received chemotherapy, and a subset (38%) also underwent prior pulmonary metastasectomy. Median patient age was 56 (12-85), and median follow-up time was 20 months (range 3-43). A total of 25 lesions were treated and evaluable for this analysis. Most common histologies were leiomyosarcoma (28%), synovial sarcoma (20%), and osteosarcoma (16%). Median SBRT prescription dose was 54 Gy (36-54) in 3-4 fractions. At 43 months, local control was 94%. No patient experienced G2-4 radiation pneumonitis, and no patient experienced radiation esophagitis. Conclusions. Our retrospective experience suggests that SBRT for LM from HGS provides excellent local control and minimal toxicity.
authors.affiliation: Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 200 UCLA Medical Plaza, B265, Los Angeles, CA 90095, USA.
authors.forename: Niraj
authors.initials: N
authors.lastname: Mehta
authors.forename: Michael
authors.initials: M
authors.lastname: Selch
authors.forename: Pin-Chieh
authors.initials: PC
authors.lastname: Wang
authors.forename: Noah
authors.initials: N
authors.lastname: Federman
authors.forename: Jay M
authors.initials: JM
authors.lastname: Lee
authors.forename: Fritz C
authors.initials: FC
authors.lastname: Eilber
authors.forename: Bartosz
authors.initials: B
authors.lastname: Chmielowski
authors.forename: Nzhde
authors.initials: N
authors.lastname: Agazaryan
authors.forename: Michael
authors.initials: M
authors.lastname: Steinberg
authors.forename: Percy
authors.initials: P
authors.lastname: Lee