title: [Chemotherapy in male external genital organs (testicular and penile cancer)].
abstract: OBJECTIVE
  To describe drugs used in the chemotherapy of testis and penis neoplasms.
  
  
  METHODS
  Bibliographical search was performed from the database Medline (National Library of Medicine, PubMed) and websites of the HAS and the ANSM. The search was focused on the characteristics, the mode of action, the efficiency and the side effects of the various drugs concerned.
  
  
  RESULTS
  Nowadays, the chemotherapy is perfectly codified in adjuvant treatment or in first-line treatment of metastatic testis cancer. A single dose of carboplatin for seminoma testicular (stage I) in adjuvant treatment situation is one of the latest advances. Concerning penis cancer, the optimal protocols validated by a high level of evidence are missing.
  
  
  CONCLUSIONS
  The chemotherapy in testis and penis neoplasms knew few advances in recent years. So, it is necessary to include patients in clinical research protocols.
authors.affiliation: Service d'oncologie, hôpital de la Timone, Aix-Marseille université, AP-HM, 13385 Marseille cedex 5, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Deville
authors.forename: A
authors.initials: A
authors.lastname: Flechon
authors.forename: F
authors.initials: F
authors.lastname: Bruyère
authors.forename: G
authors.initials: G
authors.lastname: Karsenty
authors.forename: L
authors.initials: L
authors.lastname: Guy
authors.forename: C
authors.initials: C
authors.lastname: Bastide
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000191:economics / Q000627:therapeutic use; D001761:Bleomycin / Q000191:economics / Q000627:therapeutic use; D016190:Carboplatin / Q000191:economics / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000191:economics / Q000627:therapeutic use; D015925:Cryopreservation; D005047:Etoposide / Q000191:economics / Q000627:therapeutic use; D005472:Fluorouracil / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000191:economics / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000191:economics / Q000627:therapeutic use; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000628:therapy; D009919:Orchiectomy; D017239:Paclitaxel / Q000191:economics / Q000627:therapeutic use; D010412:Penile Neoplasms / Q000188:drug therapy*; D013094:Spermatozoa; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000191:economics / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil; D007069:Ifosfamide; D008727:Methotrexate
keywords: Cancer; Chemotherapy; Chimiothérapie; Neoplsams; Penis; Pénis; Testicule; Testis