title: The role of mitochondria in age-related hearing loss.
abstract: Age-related hearing loss (ARHL), the hearing loss associated with aging, is a vital problem in present society. The severity of hearing loss is possibly associated with the degeneration of cochlear cells. Mitochondria play a key role in the energy supply, cellular redox homeostasis, signaling, and regulation of programmed cell death. In this review, we focus on the central role of mitochondria in ARHL. The mitochondrial redox imbalance and mitochondrial DNA mutation might collaboratively involve in the process of cochlear senescence in response to the aging stress. Subsequent responses, including alteration of mitochondrial biogenesis, mitophagy, apoptosis and paraptosis, participate in the aging process from different respects.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China.
authors.forename: Hengchao
authors.initials: H
authors.lastname: Chen
authors.forename: Jianguo
authors.initials: J
authors.lastname: Tang
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D003051:Cochlea / Q000503:physiopathology*; D004272:DNA, Mitochondrial / Q000235:genetics; D034381:Hearing Loss / Q000209:etiology* / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D009154:Mutation / Q000235:genetics; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial