title: Comparison of the Protective Effects of Radix Astragali, α-Lipoic Acid, and Vitamin E on Acute Acoustic Trauma.
abstract: OBJECTIVE
  Oxidative damage is a critical role which involves hearing loss induced by impulse noise. That exogenous antioxidant agents reduce noise induced hearing loss (NIHL) has been well demonstrated in both animal studies and clinical practices. Choosing a stronger and more effective antioxidant is very important for treatment of NIHL. Vitamin E, α-lipoic acid, and radix astragali are the most commonly used anti-oxidants for cochlear oxidative damage from acoustic trauma. In this study, the protective effects of radix astragali, α-lipoic acid, and vitamin E on acute acoustic trauma are investigated.
  
  
  METHODS
  Guinea pigs in the experimental groups were intragastrically administered vitamin E, α-lipoic acid, and radix astragali. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) at click and tone bursts of 8, 16 and 32 kHz, 24 hours before and 72 hours after exposure to impulse noise. Cochlear malondialdehyde (MDA) concentrations were detected. Hair cell damage was analyzed by scanning electron microscopy.
  
  
  RESULTS
  Vitamin E, α-lipoic acid, and radix astragali significantly reduced ABR deficits, reduced hair cell damage, and decreased the concentrations of MDA. α-lipoic acid and radix astragali were better than vitamin E, and there were no significant differences between α-lipoic acid and radix astragali.
  
  
  CONCLUSIONS
  α-lipoic acid or radix astragali are recommended for treatment of NIHL.
authors.affiliation: Department of Otolaryngology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xiong
authors.forename: Huangwen
authors.initials: H
authors.lastname: Lai
authors.forename: Chuanhong
authors.initials: C
authors.lastname: Yang
authors.forename: Weiyi
authors.initials: W
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Fu
authors.forename: Qinglian
authors.initials: Q
authors.lastname: He
keywords: cochlea; hearing loss; impulse noise; malondialdehyde; radix astragali; reactive oxygen species; vitamin E; α-lipoic acid