title: Choroidal thickness in the subtypes of angle closure: an EDI-OCT study.
abstract: OBJECTIVE
  To evaluate choroidal thickness (CT) in the subtypes of angle-closure (AC) disease compared with CT in a healthy control.
  
  
  METHODS
  A total of 297 subjects (eyes) were enrolled in the study: 87 were nonglaucoma controls and 210 were AC subtype eyes (primary AC suspect [PACS], 73 eyes; acute primary AC [APAC], 46 eyes; primary AC [PAC], 35 eyes; and primary AC glaucoma [PACG], 56 eyes). Enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) was used to measure the macular CT in the subtypes of AC disease and in healthy control subjects. The average CT was compared among the five groups.
  
  
  RESULTS
  Thinner CT was associated with older age and longer axial length (AL) (all P < 0.001). All AC groups had thicker subfoveal CT (SFCT) compared with the control eyes (all P < 0.05), even after controlling for age and the AL factor. Acute primary angle-closure eyes had the thickest SFCT and were 61.9-μm thicker than healthy eyes, while PACS, PAC, and PACG eyes were 32.9-, 30.9-, and 25.4-μm thicker than healthy eyes, respectively. No significant difference was observed among the PACS, PAC, and PACG groups.
  
  
  CONCLUSIONS
  Increased CT might be another anatomic characteristic of AC eyes. These findings may support the hypotheses that choroidal expansion is a contributing factor to the development of AC disease.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xinbo
authors.initials: X
authors.lastname: Gao
authors.forename: Xingyi
authors.initials: X
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Minwen
authors.initials: M
authors.lastname: Zhou
authors.forename: Shida
authors.initials: S
authors.lastname: Chen
authors.forename: Xiulan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002829:Choroid / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007089:Image Enhancement; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: angle-closure; choroidal thickness; enhanced depth imaging spectral-domain optical coherence tomography