title: Interdependent effects of sound duration and amplitude on neuronal onset response in mice inferior colliculus.
abstract: In this study, we adopted iso-frequency pure tone bursts to investigate the interdependent effects of sound amplitude/intensity and duration on mice inferior colliculus (IC) neuronal onset responses. On the majority of the sampled neurons (n=57, 89.1%), sound amplitude and duration had effects on the neuronal response to each other by showing complex changes of the rat-intensity function/duration selectivity types and/or best amplitudes (BAs)/durations (BDs), evaluated by spike counts. These results suggested that the balance between the excitatory and inhibitory inputs set by one acoustic parameter, amplitude or duration, affected the neuronal spike counts responses to the other. Neuronal duration selectivity types were altered easily by the low-amplitude sounds while the changes of rate-intensity function types had no obvious preferred stimulus durations. However, the first spike latencies (FSLs) of the onset response neurons were relative stable to iso-amplitude sound durations and changing systematically along with the sound levels. The superimposition of FSL and duration threshold (DT) as a function of stimulus amplitude after normalization indicated that the effects of the sound levels on FSLs are considered on DT actually.
authors.affiliation: Department of Physiology, School of Basic Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Ningqian
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Physiology, School of Basic Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Physiology, School of Basic Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Physiology, School of Basic Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Physiology, School of Basic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address: xiaozj@fimmu.com.
authors.forename: Zhongju
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D005260:Female; D007245:Inferior Colliculi / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000502:physiology*; D011571:Psychoacoustics; D011930:Reaction Time / Q000502:physiology*; D013997:Time Factors
keywords: BA; BD; CF; DT; Duration selectivity; Duration threshold; FSL; First spike latency; IC; Inferior colliculus; MT; Rate-intensity function; Spike counts; best amplitude; best duration; characteristic frequency; duration threshold; first spike latency; inferior colliculus; minimum threshold