title: Adult immunization with 13-valent pneumococcal vaccine in Campania region, South Italy: an economic evaluation.
abstract: Pneumococcal pneumonia has a high clinical burden in terms of morbidity, mortality and hospitalization rate, with heavy implications for worldwide health systems. In particular, higher incidence and mortality rates of community-acquired pneumonia (CAP) cases, with related costs, are registered among elderly. This study aimed to an economic evaluation about the immunization with PCV13 in the adult population in Campania region, South Italy. For this purpose we performed, considering a period of 5 y, a budget impact analysis (BIA) and a cost-effectiveness analysis which considered 2 scenarios of immunization compared with lack of immunization for 2 targeted cohorts: first, the high risk subjects aged 50-79 y, and second the high risk individuals aged 50-64 y, together with all those aged 65 y. Regarding the first group, the decrease of pneumonia could give savings equal to €29,005,660, while the immunization of the second cohort could allow savings equal to €10,006,017. The economic evaluation of pneumococcal vaccine for adult groups represents an essential instrument to support health policies. This study showed that both hypothesized immunization strategies could produce savings. Obtained results support the use of pneumococcal conjugate vaccine for adults. This strategy could represent a sustainable and savings-producer health policy.
authors.affiliation: Chair of Hygiene and Epidemiology; Department of Studies of Institutions and Territorial Systems; University of Naples "Parthenope"; Naples, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Liguori
authors.affiliation: Complex Operative Unit "Epidemiology and Prevention"; Local Health Authority NA2 Nord; Naples, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Parlato
authors.affiliation: Complex Operative Unit of the hospital Monaldi "Second Division of Respiratory Diseases"; University of Naples Federico II; Naples, Italy.
authors.forename: Alessandro Sanduzzi
authors.initials: AS
authors.lastname: Zamparelli
authors.affiliation: Chair of Hygiene and Epidemiology; Department of Studies of Institutions and Territorial Systems; University of Naples "Parthenope"; Naples, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Belfiore
authors.affiliation: Chair of Hygiene and Epidemiology; Department of Studies of Institutions and Territorial Systems; University of Naples "Parthenope"; Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Gallé
authors.affiliation: Chair of Hygiene and Epidemiology; Department of Studies of Institutions and Territorial Systems; University of Naples "Parthenope"; Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Di Onofrio
authors.affiliation: General Hospital "Federico II"-Institutional Relationships Hospitals and Local Health Authorities of Campania Region; Naples, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Riganti
authors.affiliation: "SS Annunziata"-"Santobono-Pausilipon" Hospital; Naples, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Zamparelli
mesh_terms: D000368:Aged; D003362:Cost-Benefit Analysis; D006801:Humans; D007114:Immunization / Q000191:economics* / Q000379:methods; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011008:Pneumococcal Infections / Q000191:economics / Q000453:epidemiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000191:economics* / Q000276:immunology*
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines
keywords: adult immunization; budget impact analysis; conjugate vaccine; economic evaluation; pneumococcal diseases