title: Intracellular mechanisms mediating gonadotropin and growth hormone release in the goldfish, Carassius auratus.
abstract: Evidence for the involvement of Ca(2+), protein kinase C, cAMP, and arachidonic acid metabolism in mediating gonadotropin (GTH) and growth hormone (GH) release in the goldfish is reviewed. Models for the signal transduction pathways mediating GTH-releasing hormone (GnRH) and dopamine actions on GTH and GH secretion are postulated. A novel hypothesis that two GnRHs which bind to the same receptor type activate different transduction cascade in two different cell types (GTH vs. GH) as well as within the same cell type (GTH) is presented.
authors.affiliation: Department of Zoology, University of Alberta, Edmonton, Alberta, Canada, T6G2E9.
authors.forename: J P
authors.initials: JP
authors.lastname: Chang
authors.forename: R M
authors.initials: RM
authors.lastname: Jobin
authors.forename: A O
authors.initials: AO
authors.lastname: Wong