title: A method of semi-quantifying β-AP in brain PET-CT 11C-PiB images.
abstract: Alzheimer's disease (AD) is a common health problem for elderly populations. Positron emission tomography-computed tomography (PET-CT)11C-PiB for beta-P (amyloid-β peptide, β-AP) imaging is an advanced method to diagnose AD in early stage. However, in practice radiologists lack a standardized value to semi-quantify β-AP. This paper proposes such a standardized value: SVβ-AP. This standardized value measures the mean ratio between the dimension of β-AP areas in PET and CT images. A computer aided diagnosis approach is also proposed to achieve SVβ-AP. A simulation experiment was carried out to pre-test the technical feasibility of the CAD approach and SVβ-AP. The experiment results showed that it is technically feasible.
authors.affiliation: Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China.
authors.forename: Jiehui
authors.initials: J
authors.lastname: Jiang
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Lin
authors.forename: Junlin
authors.initials: J
authors.lastname: Wen
authors.forename: Zhemin
authors.initials: Z
authors.lastname: Huang
authors.forename: Zhuangzhi
authors.initials: Z
authors.lastname: Yan
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000814:Aniline Compounds; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes / Q000737:chemistry; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D007091:Image Processing, Computer-Assisted; D049268:Positron-Emission Tomography; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals / Q000737:chemistry; D012015:Reference Standards; D015203:Reproducibility of Results; D013844:Thiazoles; D014057:Tomography, X-Ray Computed
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: 11C-PiB; Alzheimer's Disease (AD); Beta-Amyloid Peptide; Positron Emission Tomography (PET); Standardized Uptake Values (SUVs)