title: Evaluation of adverse events reported in traditional Iranian medicine following administration of aqueous extract of herba portulacae oleraceae seed.
abstract: OBJECTIVE
  To find scientific reasons for adverse events reported in Traditional Iranian Medicine (TIM) following administration of aqueous extract of Herba Portulacae Oleraceae seed including itching and tingling of whole body, tachycardia, anxiety, dyspnea and severe nausea.
  
  
  METHODS
  Electronic databases including PubMed, Scopus, and Web of Science were searched up to April 2013 to find papers focused on phytochemistry and biological activities of this plant.
  
  
  RESULTS
  Among chemical constituents present in Herba Portulacae oleraceae, catecholamines, adenosine and niacin can cause adverse events similar to those reported in TIM.
  
  
  CONCLUSIONS
  Because of the short duration of action of adenosine, catecholamines and niacin seems to be the major role in appearance of adverse events reported in TIM for Herba Portulacae Oleraceae seed. Mechanisms with consideration of receptor types and pharmacokinetics of catecholamine and niacin are warranted to confirm this hypothesis.
authors.affiliation: Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Mirabzadeh
authors.forename: Roja
authors.initials: R
authors.lastname: Rahimi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sahraee
mesh_terms: D006801:Humans; D007492:Iran; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects*; D031822:Portulaca / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*
chemical_list: D010936:Plant Extracts