title: Protein kinase C: an attractive target for cancer therapy.
abstract: Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance.
authors.affiliation: G. Gaslini Institute, L.go G. Gaslini 5, 16147, Genoa, Italy. cinzia.domenicotti@unige.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Marengo
authors.forename: Chiara
authors.initials: C
authors.lastname: De Ciucis
authors.forename: Roberta
authors.initials: R
authors.lastname: Ricciarelli
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pronzato
authors.forename: Umberto M
authors.initials: UM
authors.lastname: Marinari
authors.forename: Cinzia
authors.initials: C
authors.lastname: Domenicotti