title: New constituents from the Korean sponge Plakortis simplex.
abstract: Six new cyclic peroxides (1-6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 1-6 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.
authors.affiliation: Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Korea. jrrho@kunsan.ac.kr.
authors.forename: Jung Soon
authors.initials: JS
authors.lastname: Oh
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Ok-Hwa
authors.initials: OH
authors.lastname: Kang
authors.forename: Dong-Yeul
authors.initials: DY
authors.lastname: Kwon
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002176:Candida albicans / Q000187:drug effects; D002478:Cells, Cultured; D051379:Mice; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology*; D047229:Plakortis / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D010545:Peroxides