title: Current trends in the design of scaffolds for computer-aided tissue engineering.
abstract: Advances introduced by additive manufacturing have significantly improved the ability to tailor scaffold architecture, enhancing the control over microstructural features. This has led to a growing interest in the development of innovative scaffold designs, as testified by the increasing amount of research activities devoted to the understanding of the correlation between topological features of scaffolds and their resulting properties, in order to find architectures capable of optimal trade-off between often conflicting requirements (such as biological and mechanical ones). The main aim of this paper is to provide a review and propose a classification of existing methodologies for scaffold design and optimization in order to address key issues and help in deciphering the complex link between design criteria and resulting scaffold properties.
authors.affiliation: Tissue Engineering Laboratory, CIR - Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: S M
authors.initials: SM
authors.lastname: Giannitelli
authors.affiliation: Biomedical Robotics and Biomicrosystems Laboratory, CIR - Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Accoto
authors.affiliation: Tissue Engineering Laboratory, CIR - Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Trombetta
authors.affiliation: Tissue Engineering Laboratory, CIR - Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128 Rome, Italy. Electronic address: a.rainer@unicampus.it.
authors.forename: A
authors.initials: A
authors.lastname: Rainer
mesh_terms: D017076:Computer-Aided Design / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: Additive manufacturing; Computer-aided tissue engineering (CATE); Scaffolds; Topological optimization