title: Use of antidepressant medication in the United States during pregnancy, 2002-2010.
abstract: OBJECTIVE
  The authors analyzed prescribing for antidepressant medications during 27,328 prenatal visits in ambulatory settings in the United States between 2002 and 2010.
  
  
  METHODS
  Data from the 2002-2010 National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey were used to compare prescribing for antidepressant medication during visits for outpatient prenatal care between 2002-2006 and 2007-2010.
  
  
  RESULTS
  Prenatal visits associated with a prescription for an antidepressant increased from .7% in 2002-2006 to 2.1% in 2007-2010 (p<.01). The proportion of prescriptions for selective serotonin reuptake inhibitors (SSRIs) declined (from 87% to 66%, p=.04), particularly for paroxetine (from 19% to <1%, p<.01).
  
  
  CONCLUSIONS
  Despite controversy over possible negative effects, prescribing of antidepressants during pregnancy increased between 2002 and 2010. SSRIs represented a smaller proportion of all antidepressants prescribed, and prescribing of paroxetine, likely in response to warnings by the U.S. Food and Drug Administration, dropped dramatically.
authors.forename: Matthew Ryan
authors.initials: MR
authors.lastname: Meunier
authors.forename: Ian M
authors.initials: IM
authors.lastname: Bennett
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Coco
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care / Q000706:statistics & numerical data* / Q000639:trends; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004363:Drug Utilization / Q000639:trends*; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011295:Prenatal Care / Q000592:standards / Q000706:statistics & numerical data* / Q000639:trends; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors