title: Bladder function evaluation before renal transplantation in nonurologic disease: is it necessary?
abstract: OBJECTIVE
  To determine whether preoperative cystometry and a pressure flow study (PFS) are necessary in patients with end-stage renal disease from nonurologic causes who will undergo renal transplantation.
  
  
  METHODS
  From April 2009 to June 2010, 30 patients scheduled to undergo renal transplantation were prospectively evaluated with cystometry and PFS. The evaluation was performed immediately before and 6 months after renal transplantation. The inclusion criteria were age >18 years and end-stage renal disease secondary to nonurologic disease.
  
  
  RESULTS
  Improvement in the cystometry and PFS parameters was observed after the return of diuresis at 6 months after transplantation. The parameter changes from baseline to the 6-month evaluation were as follows: first sensation of bladder filling, 88.8-168.7 mL (P = .0005); first desire to void, 137.2-251.1 mL (P <.0001); maximal cystometric capacity, 221.2-428.7 mL (P <.0001); bladder compliance, 73.9-138.6 mL/cm H2O (P = .03); and maximal flow rate, 8.1-15.8 mL/s (P <.0001). The Abrams-Griffiths number in the men decreased from 31.8 to 15.2 (P = .002). No significant changes were observed in the detrusor pressure at the maximal flow rate or the postvoid residual urine volume. Patients with a 24-hour urine output <200 mL tended to have had significantly worse parameters before transplantation.
  
  
  CONCLUSIONS
  Significant improvement in the cystometry and PFS parameters was observed in patients with end-stage renal disease, without urologic disease, 6 months after transplantation, and was associated with recovery of the glomerular filtration rate and urine output by the renal graft.
authors.affiliation: Department of Urology, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: danielurologia@hotmail.com.
authors.forename: Daniel Moser
authors.initials: DM
authors.lastname: Silva
authors.affiliation: Department of Urology, University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Alessandro Correia
authors.initials: AC
authors.lastname: Prudente
authors.affiliation: Department of Nephrology, University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Marilda
authors.initials: M
authors.lastname: Mazzali
authors.affiliation: Department of Urology, University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Claudio Ferreira
authors.initials: CF
authors.lastname: Borges
authors.affiliation: Department of Urology, University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: D'Ancona
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003950:Diagnostic Techniques, Urological; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D001743:Urinary Bladder / Q000502:physiology*; D055815:Young Adult