title: Effect of patient-controlled sedation with propofol on patient satisfaction: a randomized study.
abstract: BACKGROUND
  In this trial we sought to determine whether propofol-based patient-controlled sedation (PCS) during diagnostic cerebral angiography would result in improved patient satisfaction compared to placebo-based PCS.
  
  
  METHODS
  We randomly assigned 61 patients to receive propofol-based PCS (n=33, 15mg bolus in 9 s) or placebo-based PCS (n=28, bolus of 1.5mL of a 20% lipid emulsion in 9 s). We recorded the number of PCS bolus requirements, the need for rescue sedative drugs, and physiological variables. Prior to the procedure, the anxiety level of each patient was evaluated using the Anxiety State Traits Assessment (STAI) and the Amsterdam Preoperative Anxiety and Information Scale (APAIS). The quality of patient conditioning was quoted by both the anesthetist and neuroradiologist using Visual Analog Scale (VAS). The day following the procedure, patients were given the EVAN questionnaire, a validated tool for assessing patient satisfaction.
  
  
  RESULTS
  Both groups were similar in term of demographics, American Society of Anesthesiologist (ASA) physical status scores, STAI and APAIS scores, and procedure lengths. There were no differences between groups in EVAN scores 76.9±16.1 vs. 75.7±12.8; P=0.78. The number of PCS bolus requirements was significantly higher in the placebo group 3.96±9.5 vs. 3.13±3.1 (P=0.02). No adverse event was recorded.
  
  
  CONCLUSIONS
  This prospective, double-blind, randomized study showed that sedation using propofol PCS did not improve patients' satisfaction during diagnostic cerebral angiography. Therefore, an anesthetist should be rapidly available on request but not necessarily present during the whole procedure.
authors.affiliation: Pôle d'anesthésie-réanimation, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex, France. Electronic address: amszamburski@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Maurice-Szamburski
authors.forename: A
authors.initials: A
authors.lastname: Loundou
authors.forename: P
authors.initials: P
authors.lastname: Auquier
authors.forename: N
authors.initials: N
authors.lastname: Girard
authors.forename: N
authors.initials: N
authors.lastname: Bruder
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000523:psychology; D002533:Cerebral Angiography; D016292:Procedural Sedation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011446:Prospective Studies; D018401:Sample Size; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol
keywords: PCS; Patient reported outcome; Propofol; Sédation contrôlée par le patient