title: Basic science of bone healing.
abstract: Bone healing is a complex process that can be influenced by both host and environmental factors. In this article, we review the biology involved in the regeneration of new bone after fracture, and factors influencing bone healing, including diabetes, smoking, NSAID use, and bisphosphonates.
authors.affiliation: Department of Orthopaedic Surgery, Penn State Milton S. Hershey Medical Center, 30 Hope Drive, PO Box 859, Hershey, PA 17033, USA.
authors.forename: Vikram
authors.initials: V
authors.lastname: Sathyendra
authors.forename: Michael
authors.initials: M
authors.lastname: Darowish
mesh_terms: D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology*; D017102:Fracture Healing / Q000502:physiology*; D050723:Fractures, Bone / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Fracture healing; Primary healing; Secondary healing