title: ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients.
abstract: OBJECTIVE
  Major depressive disorder is a common psychiatric disorder with worldwide prevalence. The most widely prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs). ATP-binding cassette proteins are responsible for the membrane transport of various molecules including antidepressive drugs. We investigated whether SNPs in ABCB6, ABCB1 and ABCG1 were associated with the treatment response of SSRIs.
  
  
  METHODS
  A pharmacogenetic study genotyping nine SNPs was conducted in 290 major depressive disorder patients in the Chinese Han population. Allele and genotype frequencies were compared between responders and nonresponders.
  
  
  RESULTS
  The allele frequencies of rs28401781 and rs4148739 in ABCB1 showed significant difference between responders and nonresponders before correction (p = 0.0297 and p = 0.0359, respectively). No significant associations were detected for the ABCB6 or ABCG1 gene.
  
  
  CONCLUSIONS
  Our results suggest that ABCB1 polymorphisms might be associated with SSRIs treatment response in the Chinese Han population.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Cao
authors.forename: Xingwang
authors.initials: X
authors.lastname: Li
authors.forename: Baocheng
authors.initials: B
authors.lastname: Liu
authors.forename: Fengping
authors.initials: F
authors.lastname: Yang
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.forename: Xinzhi
authors.initials: X
authors.lastname: Zhao
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Zaiquan
authors.initials: Z
authors.lastname: Dong
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Xueli
authors.initials: X
authors.lastname: Sun
authors.forename: Guang
authors.initials: G
authors.lastname: He
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage; D002681:China; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters; D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors; C513055:ABCB1 protein, human; C107991:ABCB6 protein, human; C419353:ABCG1 protein, human