title: Fabrication of biomolecules self-assembled on Au nanodot array for bioelectronic device.
abstract: In the present study, an nano-platform composed of Au nanodot arrays on which biomolecules could be self-assembled was developed and investigated for a stable bioelectronic device platform. Au nanodot pattern was fabricated using a nanoporous alumina template. Two different biomolecules, a cytochrome c and a single strand DNA (ssDNA), were immobilized on the Au nanodot arrays. Cytochorme c and single stranded DNA could be immobilized on the Au nanodot using the chemical linker 11-MUA and thiol-modification by covalent bonding, respectively. The atomic structure of the fabricated nano-platform device was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The electrical conductivity of biomolecules immobilized on the Au nanodot arrays was confirmed by scanning tunneling spectroscopy (STS). To investigate the activity of biomolecule-immobilized Au-nano dot array, the cyclic voltammetry was carried out. This proposed nano-platform device, which is composed of biomolecules, can be used for the construction of a novel bioelectronic device.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Republic of Korea.
authors.forename: Taek
authors.initials: T
authors.lastname: Lee
authors.forename: Ajay Yagati
authors.initials: AY
authors.lastname: Kumar
authors.forename: Si-Youl
authors.initials: SY
authors.lastname: Yoo
authors.forename: Mi
authors.initials: M
authors.lastname: Jung
authors.forename: Junhong
authors.initials: J
authors.lastname: Min
authors.forename: Jeong-Woo
authors.initials: JW
authors.lastname: Choi
mesh_terms: D001483:Base Sequence; D045304:Cytochromes c / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D004581:Electronics; D006046:Gold / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures
chemical_list: D004277:DNA, Single-Stranded; D006046:Gold; D045304:Cytochromes c