title: [Hyperandrogenism in women].
abstract: Clinical signs of hyperandrogenism include hirsutism, acne and/or seborrhea, androgenic alopecia, menstrual disorders and at maximum virilization. Hirsutism is defined by the presence of a coarse and pigmented hair in male territory. In the Caucasian populations, a Ferriman Gallwey score ≥ 6 means hirsutism. Polycystic ovary syndrome is the most common cause of hyerandrogenism in women (70 % of cases) but must remain a diagnosis of exclusion. A neoplasm origin is suspected in case of recent onset of hyperandrogenism, which is rapidly progressive and with signs of virilization. The serum level of total testosterone and 17-hydroxyprogesterone and pelvic ultrasonography are the first line tests in case of clinical hyperandrogenism. Combined oral contraceptive pill can be the first line treatment in case of moderate hyperandrogenia, associated, if needed, with a specific acne treatment. Cyproterone acetate is the best-known and most effective antiandrogenic treatment. It decreases the hair density, speed of regrowth and pigmentation. It is indicated in severe hirsutism and must be combined with cosmetic cares.
authors.affiliation: Hôpital Jeanne de Flandre, département de gynécologie, service de gynécologie endocrinienne et de médecine de la reproduction, 59037 Lille cedex, France. Electronic address: maeliss_peigne@hotmail.com.
authors.forename: Maëliss
authors.initials: M
authors.lastname: Peigné
authors.forename: Anne
authors.initials: A
authors.lastname: Villers-Capelle
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Robin
authors.forename: Didier
authors.initials: D
authors.lastname: Dewailly
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology; D000307:Adrenal Gland Diseases / Q000150:complications; D012628:Dermatitis, Seborrheic / Q000209:etiology; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications; D014770:Virilism / Q000209:etiology