title: Effects of bioactive lipids and lipoproteins on bone.
abstract: Although epidemiological studies from the past two decades show a link between atherosclerotic vascular disease and bone loss, that is independent of age, the mechanism is still unclear. This review focuses on evidence that suggests a role for atherogenic lipids and lipoproteins in the pathogenesis of bone loss, including direct effects of these bioactive lipids/lipoproteins on bone cells, inhibiting osteoblastic differentiation and promoting osteoclastic differentiation. It also addresses recent evidence that suggests that bioactive lipids blunt the effects of bone anabolic agents such as teriparatide and bone morphogenetic proteins. Systemic and intracellular oxidant stress and inflammation are implicated in mediating the effects of bioactive lipids/lipoproteins.
authors.affiliation: Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: ytintut@mednet.ucla.edu.
authors.forename: Yin
authors.initials: Y
authors.lastname: Tintut
authors.affiliation: Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Physiology, University of California, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
authors.forename: Linda L
authors.initials: LL
authors.lastname: Demer
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology; D000818:Animals; D050197:Atherosclerosis; D015519:Bone Density; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002454:Cell Differentiation; D008076:Cholesterol, HDL / Q000378:metabolism; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology; D008055:Lipids / Q000502:physiology*; D008074:Lipoproteins / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010024:Osteoporosis / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000494:pharmacology
chemical_list: D045930:Anabolic Agents; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D010281:Parathyroid Hormone