title: G-CSF in Healthy Allogeneic Stem Cell Donors.
abstract: Mobilization of peripheral blood stem cells (PBSC) in healthy volunteers with granulocyte colony-stimulating factor (G-CSF) is currently carried out at many institutions worldwide. This report presents the experience of the Dresden center regarding donor evaluation and mobilization schedule. Data regarding efficacy, short- and long-term safety of G-CSF treatment gained from 8290 PBSC collections in healthy donors are outlined. These results are discussed against the background of the available evidence from the literature. Although established as a standard procedure, G-CSF application to allogeneic donors will always be a very delicate procedure and requires the utmost commitment of all staff involved to ensure maximum donor safety.
authors.affiliation: Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Hölig
keywords: CD34+ cells; Donors; G-CSF; Hematopoietic stem cells; Leukapheresis product