title: Hyaluronic acid as an internal phase additive to obtain ofloxacin/PLGA microsphere by double emulsion method.
abstract: Hyaluronic acid (HA) was used as an internal phase additive to improve the loading efficiency of ofloxacin, a hydrophilic drug encapsulated by hydrophobic polylactic-co-glycolic acid (PLGA) materials, through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Results from laser distribution analysis show that polyelectrolyte additives have low impact on the average particle size and distribution of the microspheres. The negatively charged HA increases the drug loading efficiency as well as the amount of HA in microspheres. Burst release can be observed in the groups with the polyelectrolyte additives. The release rate decreases with the amount of HA inside the microspheres in all negatively charged polyelectrolyte-added microsphere groups.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China National Engineering Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Ying-jun
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002138:Calibration; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000737:chemistry; D004655:Emulsions; D006820:Hyaluronic Acid / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D007834:Lasers; D008863:Microspheres; D015242:Ofloxacin / Q000008:administration & dosage*; D009821:Oils / Q000737:chemistry; D009997:Osmotic Pressure; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D033081:Shear Strength; D012997:Solvents / Q000737:chemistry; D055672:Static Electricity; D013314:Stress, Mechanical; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004573:Electrolytes; D004655:Emulsions; D009821:Oils; D011108:Polymers; D012997:Solvents; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D006820:Hyaluronic Acid; D015242:Ofloxacin
keywords: Drug release; hyaluronic acid; microsphere; ofloxacin