title: Interleukins and atherosclerosis: a dysfunctional family grows.
abstract: Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis, MO 63110, USA.
authors.forename: Larry D
authors.initials: LD
authors.lastname: Spears
authors.forename: Babak
authors.initials: B
authors.lastname: Razani
authors.forename: Clay F
authors.initials: CF
authors.lastname: Semenkovich
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D053582:Interleukin-1alpha / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D014657:Vasculitis / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D058847:Inflammasomes; D053582:Interleukin-1alpha