title: Combined treatment for cutaneous Rosai-Dorfman disease: a report of 2 cases.
abstract: We report 2 cases of cutaneous Rosai-Dorfman disease (CRDD). One was a 46-year-old Chinese woman who presented with a 10-year history of multiple papules and nodules on the left cheek. Another one was a 57-year-old Chinese woman who presented with a 7-month history of erythematous pruritic plaque on the Dorsum nasi. Their lesions consisted of proliferative large histiocytes occasionally showing emperipolesis. Immunohistochemistry showed these histiocytes were positive for CD68 and S-100, but negative for CD1a. A diagnosis of CRDD was made. Their lesions were improved after intralesional treatment with Compound Betamethasone, interferon and acitretin. To our knowledge, we for the first time reported the application of intralesional Compound Betamethasone and Lidocaine, intramuscular injection of interferon, and oral acitretin in the treatment of CRDD, and favorable outcome was achieved without recurrence over a 1-year follow-up period.
authors.affiliation: Department of Dermatology, The Second Hospital of Jilin University Changchun 130041, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Xia
authors.forename: Xian-Hua
authors.initials: XH
authors.lastname: Jin
authors.forename: Yan
authors.initials: Y
authors.lastname: Mou
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Zhu
authors.forename: Fu-Qiu
authors.initials: FQ
authors.lastname: Li
keywords: Chinese; Cutaneous Rosai-Dorfman disease; intralesional Compound Betamethasone and lidocaine; intramuscular injection of interferon; oral acitretin