title: Amygdala-mediated enhancement of memory for specific events depends on the hippocampus.
abstract: Emotional events are often remembered better than neutral events, a type of memory prioritization by affective salience that depends on the amygdala. Studies with rats have indicated that direct activation of the basolateral complex of the amygdala (BLA) can enhance memory for neutral events, and if the activation is brief and temporally targeted, can do so in a way that benefits memories for specific events. The essential targets of BLA activation in the case of event-specific memory enhancement were unknown, but the hippocampus was known to receive direct projections from the BLA and to support memory for events. In the present study, rats received counterbalanced infusions of either muscimol, a GABAA receptor agonist, or saline into the hippocampus prior to performing a novel object recognition memory task during which initial encounters with some of the objects were immediately followed by brief electrical stimulation to the BLA. When memory was tested 1day later in the saline condition, rats remembered these objects well but showed no memory for objects for which the initial encounter had not been followed by BLA stimulation. In contrast, no benefit to memory of BLA stimulation was observed in the muscimol condition. The results indicated that brief activation of the BLA can prioritize memories for events by enhancing memory for some object encounters but not others and that this benefit to memory depends on interactions between the amygdala and the hippocampus.
authors.affiliation: Graduate Program in Neuroscience, Emory University, Atlanta, GA 30322, United States.
authors.forename: David I
authors.initials: DI
authors.lastname: Bass
authors.affiliation: Neuroscience and Behavioral Biology Program, Emory University, Atlanta, GA 30322, United States.
authors.forename: Zainab G
authors.initials: ZG
authors.lastname: Nizam
authors.affiliation: Neuroscience and Behavioral Biology Program, Emory University, Atlanta, GA 30322, United States.
authors.forename: Kristin N
authors.initials: KN
authors.lastname: Partain
authors.affiliation: Neuroscience and Behavioral Biology Program, Emory University, Atlanta, GA 30322, United States.
authors.forename: Arick
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Psychology, Emory University, Atlanta, GA 30322, United States. Electronic address: jmanns@emory.edu.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Manns
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*
chemical_list: D009118:Muscimol
keywords: Basolateral amygdala; Electrical stimulation; Fluorophore-conjugated muscimol; Hippocampus; Memory enhancement; Object recognition memory