Chiral phosphoric acid catalyzed enantioselective desymmetrization of meso-epoxides by thiols.
The first chiral Brønsted acid catalyzed asymmetric nucleophilic ring-opening reaction of meso-epoxides is described. In the presence of TRIP, a range of meso-epoxides could undergo smooth ring-opening reactions by aryl thiols with good efficiency and enantioselectivity.
Department of Chemistry, The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong SAR, China.
Zhaobin
Z
Wang
Wai Kit
WK
Law
Jianwei
J
Sun