p21-Activated kinase 5: a pleiotropic kinase.
The PAKs (p21-activated kinases) are highly conserved serine/threonine protein kinases which comprise six mammalian PAKs. PAK5 (p21-activated kinase 5) is the least understood member of PAKs that regulate many intracellular processes when they are stimulated by activated forms of the small GTPases Cdc42 and Rac. PAK5 takes an important part in multiple signal pathways in mammalian cells and controls a variety of cellular functions including cytoskeleton organization, cell motility and apoptosis. The main goal of this review is to describe the structure, mechanisms underlying its activity regulation, its role in apoptosis and the likely directions of further research.
Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou 221002, Jiangsu, China.
Yi-Yang
YY
Wen
Xiao-Xia
XX
Wang
Dong-Sheng
DS
Pei
Jun-Nian
JN
Zheng
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D015398:Signal Transduction; D051025:bcl-Associated Death Protein / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D054462:p21-Activated Kinases / Q000378:metabolism*; D048490:raf Kinases / Q000378:metabolism
D051025:bcl-Associated Death Protein; D054462:p21-Activated Kinases; D048490:raf Kinases; D020764:cdc42 GTP-Binding Protein
Apoptosis; Cancer; Mitochondria; p21-Activated kinase 5 (PAK5)