Tumor-targeting vaccination instructs graft-vs.-tumor immune responses.
Anticancer vaccines hold the potential to promote tumor eradication by immune effector cells. We have recently found dendritic cell-based vaccines to instruct graft-vs.-tumor responses following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusion. Vaccination was essential to elicit the intratumoral expression of interferon γ, promote local inflammation, and stimulate therapeutic T-cell infiltration.
Lymphocyte Activation Unit; Program in Immunology and Bio-Immunotherapy of Cancer; Division of Immunology, Transplantation and Infectious Disease; San Raffaele Scientific Institute; Milan, Italy ; Università Vita-Salute San Raffaele; Milan, Italy.
Teresa
T
Manzo
Rodrigo Hess
RH
Michelini
Tabea
T
Sturmheit
Veronica
V
Basso
Matteo
M
Bellone
Anna
A
Mondino
T cells; immunotherapy; minor histocompatibility antigens; transplantation; tumor; vaccination