Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats.
Glucagon-like peptide-1 (GLP1) and leptin are anorectic hormones. Previously, we have shown that i.p. coadministration of subthreshold GLP1 with leptin dramatically reduced food intake in rats. In this study, by using midbrain-transected rats, we investigated the role of the neural pathway from the hindbrain to the hypothalamus in the interaction of GLP1 and leptin in reducing food intake. Food intake reduction induced by coinjection of GLP1 and leptin was blocked in midbrain-transected rats. These findings indicate that the ascending neural pathway from the hindbrain plays an important role in transmitting the anorectic signals provided by coinjection of GLP1 and leptin.
Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan.
Sayaka
S
Akieda-Asai
Paul-Emile
PE
Poleni
Kazuya
K
Hasegawa
Yukari
Y
Date
D000263:Adenylate Kinase / Q000378:metabolism; D000818:Animals; D004435:Eating / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism / Q000494:pharmacology*; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D020738:Leptin / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012249:Rhombencephalon / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D020738:Leptin; D011333:Pro-Opiomelanocortin; D052216:Glucagon-Like Peptide 1; D000263:Adenylate Kinase
GLP1; food intake; leptin; midbrain transection