Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.
A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
Tsung-Hung
TH
Chen
Mei-Chin
MC
Lu
Yu-Chia
YC
Chang
Yin-Di
YD
Su
Yu-Hsin
YH
Chen
Nai-Cheng
NC
Lin
Lee-Shing
LS
Fang
Yang-Chang
YC
Wu
Ping-Jyun
PJ
Sung
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans
D004224:Diterpenes; C476503:eunicellin