Class 3 semaphorin in angiogenesis and lymphangiogenesis.
Semaphorins were originally identified as axon guidance molecules involved in the development of the neuronal system. However, accumulating evidences have clearly demonstrated that the semaphorin system is not restricted to the brain but supports functions of other organs. Here, we review the rapidly emerging functions of sempahorins and, in particular class 3 semaphorin, in vascular and lymphatic systems during the development, tumor angiogenesis and ischemic revascularization.
Department of Oncology, University of Torino, Torino, Italy.
Federico
F
Bussolino
Enrico
E
Giraudo
Guido
G
Serini
D042501:Angiogenic Proteins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000254:growth & development / Q000502:physiology; D002465:Cell Movement; D005786:Gene Expression Regulation; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D055495:Neurogenesis / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D039961:Semaphorins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D042501:Angiogenic Proteins; D009419:Nerve Tissue Proteins; C492119:PLXNB1 protein, human; D020033:Protein Isoforms; D011956:Receptors, Cell Surface; D039961:Semaphorins