Cardiac safety of diclofenac at a single dose in ram.
Nonsteroidal anti-inflammatory drugs are frequently prescribed drug group in human and veterinary medicine. However, diclofenac, a traditional nonsteroidal anti-inflammatory drug, related to cardiotoxicity is reported, and blood cardiac damage markers may increase within the first hours after damage. The aim of the current research was to determine the effect of diclofenac on the blood cardiac damage markers. Single dose of diclofenac (2.5 mg/kg, IM) was injected to 6 rams. Blood samples were collected in before (0 hour, control) and 6 hours after injection. Specific (troponin I, and creatine kinase-MB) and nonspecific (lactate dehydrogenase, aspartate aminotransferase) blood cardiac damage marker concentrations, routine biochemical (hepatic damage, renal damage, lipid metabolism, glucose, and phosphorus) parameters, and hemogram values were measured. Diclofenac increased (P < 0.05) specific (troponin I) and nonspecific cardiac (lactate dehydrogenase, aspartate aminotransferase), hepatic (aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase), and muscular (creatine kinase) damage markers and high density lipoprotein level, while it decreased (P < 0.05) low density lipoprotein level. Moreover, diclofenac decreased (P < 0.05) white blood cell counts and increased (P < 0.05) red blood cell counts. In conclusion, it may be stated that diclofenac shows slight cardiotoxicity, whereas it may show potent hepatic and muscular damage effects at an intramuscularly single dose in sheep. Thereby, repeated injections of diclofenac may be more harmful in sheep.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42075 Konya, Turkey.
Ayse
A
Er
Burak
B
Dik
Orhan
O
Corum
Gul
G
Cetin
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D015415:Biomarkers; D001773:Blood Cells / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D004008:Diclofenac / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D008099:Liver / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000139:chemically induced*; D013045:Species Specificity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D004008:Diclofenac