[Comparison of the efficacy of ropivacaine and that of levobupivacaine for postoperative epidural analgesia in patients undergoing gynecological open abdominal surgery].
BACKGROUND
Postoperative analgesia is important in patients undergoing open abdominal surgery. We prospectively compared the efficacy of ropivacaine and that of levobupivacaine for postoperative epidural analgesia in patients undergoing gynecological open abdominal surgery.


METHODS
Fifty-two ASA 1-2 patients scheduled for gynecological open abdominal surgery under combined general and epidural anesthesia were enrolled and randomized into two groups. In ropivacaine group (n = 26) the patients received 0.187% ropivacaine and fentanyl 3.2 microg x ml(-1) for postoperative epidural analgesia. In levobupivacaine group (n = 26) the patients received 0.187% levobupivacaine and fentanyl 3.2 microg ml(-1). Visual analogue scale (resting pain and pain on mobilization), the amount of rescue analgesics and epidural anesthesia related adverse events such as hypotension, nausea and vomiting were observed for 48 hours after surgery.


RESULTS
There were no differences in visual analogue scale at all intervals between the two groups. In levobupivacaine group the patients used less amounts of rescue analgesics than ropivacaine group (P = 0.01). There were no differences in the incidences of postoperative hypotension, nausea and vomiting between the two groups.


CONCLUSIONS
Both 0.187% ropivacaine and levobupivacaine similarly provide appropriate postoperative epidural analgesia for patients undergoing gynecological open abdominal surgery.
Department of Anesthesiology, Tokyo Dental College, Ichikawa General Hopital, Ichikawa 272-8513.
Azusa
A
Kato
Toshiya
T
Koitabashi
Sayaka
S
Masuda
Yuya
Y
Masuda
Takashi
T
Ouchi
Ryohei
R
Serita
D000328:Adult; D000577:Amides / Q000494:pharmacology*; D015360:Analgesia, Epidural / Q000379:methods*; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D000077554:Levobupivacaine; D010149:Postoperative Pain / Q000188:drug therapy*; D011184:Postoperative Period; D000077212:Ropivacaine
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D000077554:Levobupivacaine; D002045:Bupivacaine