Chemical genomics for studying parasite gene function and interaction.
With the development of new technologies in genome sequencing, gene expression profiling, genotyping, and high-throughput screening of chemical compound libraries, small molecules are playing increasingly important roles in studying gene expression regulation, gene-gene interaction, and gene function. Here we briefly review and discuss some recent advancements in drug target identification and phenotype characterization using combinations of high-throughput screening of small-molecule libraries and various genome-wide methods such as whole-genome sequencing, genome-wide association studies (GWAS), and genome-wide expression analysis. These approaches can be used to search for new drugs against parasite infections, to identify drug targets or drug resistance genes, and to infer gene function.
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P.R. China.
Jian
J
Li
Jing
J
Yuan
Ken Chih-Chien
KC
Cheng
James
J
Inglese
Xin-zhuan
XZ
Su
D000818:Animals; D023281:Genomics; D057166:High-Throughput Screening Assays; D009154:Mutation; D010271:Parasites / Q000235:genetics*; D010274:Parasitology / Q000639:trends*; D010641:Phenotype; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism; D059467:Transcriptome
D054852:Small Molecule Libraries
gene function; genetics; genomics; high-throughput screening