A decade after SARS: strategies for controlling emerging coronaviruses.
Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rates. There are no clinically approved vaccines or antiviral drugs available for either of these infections; thus, the development of effective therapeutic and preventive strategies that can be readily applied to new emergent strains is a research priority. In this Review, we describe the emergence and identification of novel human coronaviruses over the past 10 years, discuss their key biological features, including tropism and receptor use, and summarize approaches for developing broadly effective vaccines.
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Rachel L
RL
Graham
Eric F
EF
Donaldson
Ralph S
RS
Baric
D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000517:prevention & control*; D017934:Coronavirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity / Q000502:physiology; D018352:Coronavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D011991:Receptors, Virus / Q000378:metabolism; D056189:Viral Tropism; D014765:Viral Vaccines / Q000276:immunology / Q000302:isolation & purification
D011991:Receptors, Virus; D014765:Viral Vaccines