Hydrogels composed of cyclodextrin inclusion complexes with PLGA-PEG-PLGA triblock copolymers as drug delivery systems.
Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic diseases and specific conditions encourage scientists to invent different delivery systems. To this purpose, a supramolecular hydrogel consisting of the tri-block copolymer PLGA-PEGPLGA and α-cyclodextrin was fabricated for the first time and characterised in terms of rheological, morphological, and structural properties. Naltrexone hydrochloride and vitamin B12 were loaded, and their release profiles were determined.
Elham
E
Khodaverdi
Farnaz Sadat
FS
Mirzazadeh Tekie
Farzin
F
Hadizadeh
Haydar
H
Esmaeel
Seyed Ahmad
SA
Mohajeri
Sayyed A
SA
Sajadi Tabassi
Gholamhossein
G
Zohuri
D002626:Chemistry, Pharmaceutical / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D020100:Hydrogels / Q000737:chemistry*; D009271:Naltrexone / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011098:Polyglactin 910 / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D014805:Vitamin B 12 / Q000737:chemistry
D003505:Cyclodextrins; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; C528571:poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid); D011098:Polyglactin 910; D011092:Polyethylene Glycols; D009271:Naltrexone; D014805:Vitamin B 12