Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
OBJECTIVE
Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA.


METHODS
A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese).


RESULTS
Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group (RIMS1, BICC1 and RAD51L 1) and one region in the Han Chinese population (ABI3BP). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7. A majority of these genes are related to Ca(2+), cAMP and/or P53 signaling pathways.


CONCLUSIONS
The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA.
Research Laboratory, UGC Allergy, Málaga General Hospital, Málaga, Spain.
José Antonio
JA
Cornejo-García
Lieh-Bang
LB
Liou
Natalia
N
Blanca-López
Inmaculada
I
Doña
Chien-Hsiun
CH
Chen
Yi-Chun
YC
Chou
Hui-Ping
HP
Chuang
Jer-Yuarn
JY
Wu
Yuan-Tsong
YT
Chen
María Del Carmen
Mdel C
Plaza-Serón
Cristobalina
C
Mayorga
Rosa María
RM
Guéant-Rodríguez
Shih-Chang
SC
Lin
María José
MJ
Torres
Paloma
P
Campo
Carmen
C
Rondón
José Julio
JJ
Laguna
Javier
J
Fernández
Jean-Louis
JL
Guéant
Gabriela
G
Canto
Miguel
M
Blanca
Ming Ta Michael
MT
Lee
D000328:Adult; D000799:Angioedema / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics*; D002118:Calcium / Q000378:metabolism; D016022:Case-Control Studies; D000242:Cyclic AMP / Q000235:genetics / Q000378:metabolism; D004342:Drug Hypersensitivity / Q000235:genetics* / Q000378:metabolism; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D014581:Urticaria / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016159:Tumor Suppressor Protein p53; D000242:Cyclic AMP; D002118:Calcium