Genetic mapping of brain plasticity across development in Williams syndrome: ERP markers of face and language processing.
In Williams Syndrome (WS), a known genetic deletion results in atypical brain function with strengths in face and language processing. We examined how genetic influences on brain activity change with development. In three studies, event-related potentials (ERPs) from large samples of children, adolescents, and adults with the full genetic deletion for WS were compared to typically developing controls, and two adults with partial deletions for WS. Studies 1 and 2 identified ERP markers of brain plasticity in WS across development. Study 3 suggested that, in adults with partial deletions for WS, specific genes may be differentially implicated in face and language processing.
a School of Psychology, Bangor University , Bangor , United Kingdom.
D L
DL
Mills
L
L
Dai
I
I
Fishman
A
A
Yam
L G
LG
Appelbaum
M
M
St George
A
A
Galaburda
U
U
Bellugi
J R
JR
Korenberg
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D002648:Child; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005145:Face / Q000503:physiopathology; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008606:Mental Processes; D011930:Reaction Time; D021641:Recognition, Psychology; D013067:Speech Perception / Q000502:physiology; D018980:Williams Syndrome / Q000150:complications / Q000235:genetics / Q000503:physiopathology*