The bipolar role of miR-466l in inflammation.
Special proresolving mediators (SPMs) limit the intensity of inflammation; however, their regulation is poorly understood. In this issue of Immunity, Li et al. (2013) describe bipolar roles for miR-466l in the promotion of inflammation and the induction of SPMs.
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-5602, USA. Electronic address: pward@umich.edu.
Peter A
PA
Ward
D000818:Animals; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D009504:Neutrophils / Q000378:metabolism*; D010538:Peritonitis / Q000378:metabolism*; D018805:Sepsis / Q000097:blood*
D018836:Inflammation Mediators; C585904:MIRN466 microRNA, human; D035683:MicroRNAs; C576133:Mirn466 microRNA, mouse