Hexane extract of the seeds of Byrsonima crassifolia accelerates wound healing in streptozotocin-induced diabetic rats.
OBJECTIVE
To study the effect of seeds of Byrsonima crassifolia in diabetic wound healing.


METHODS
Wound healing potential of hexane extract in the form of simple ointment for the treatment of dermal wounds was studied in streptozotocin-induced diabetic rats on excision wound, incision wound and dead space wound. Various parameters such as epithelization period, scar area, tensile strength, hydroxyproline, total protein, DNA, hexosamine, uronic acid, antioxidant enzymes including superoxide dismutase (SOD) and catalase activity (CAT) were used to evaluate the effect of B. crassifolia on wound healing.


RESULTS
Hexane extract in form topical accelerates the wound healing process by decreasing the surface area of the wound with a significant increase in the rate of wound contraction and tensile strength; increase granulation tissue dry weight, hydroxyproline, total protein, DNA and SOD and CAT when compared with diabetic control.


CONCLUSIONS
B. crassifolia was effective in promoting diabetic wound healing in rats through the processes of tissue regeneration.
Research Laboratory of Natural Products, School of Chemical Engineering and Extractive Industries, National Polytechnic Institute, Unidad Profesional Adolfo Lopez Mateos, Zacatenco, CP 07758, Mexico D.F., rmpg@prodigy.net.mx.
Rosa Martha
RM
Pérez Gutiérrez
Alethia
A
Muñiz Ramirez