Improved survival of baby boomer women with early-stage uterine cancer: A Surveillance, Epidemiology and End Results (SEER) Study.
OBJECTIVE
To study the prognostic impact of baby boomer (BB) generation on survival end-points of patients with early-stage endometrial carcinoma (EC).


METHODS
Data were obtained from the SEER registry between 1988-2009. Inclusion criteria included women who underwent hysterectomy for stage I-II EC. Patients were divided into two birth cohorts: BB (women born between 1946 and 1964) and pre-boomers (PB) (born between 1926 and 1945).


RESULTS
A total of 30,956 patients were analyzed. Considering that women in the PB group were older than those of the BB generation, the statistical analysis was limited to women 50-59 years of age at the time of diagnosis (n=11,473). Baby boomers had a significantly higher percentage of endometrioid histology (p<0.0001), higher percentage of African American women (p<0.0001), lower tumor grade (p<0.0001), higher number of dissected lymph nodes (LN) (p<0.0001), and less utilization of adjuvant radiation therapy (p=0.0003). Overall survival was improved in women in the BB generation compared to the PB generation (p=0.0003) with a trend for improved uterine cancer-specific survival (p=0.0752). On multivariate analysis, birth cohort (BB vs. PB) was not a significant predictor of survival end-points. Factors predictive of survival included: tumor grade, FIGO stage, African-American race, and increased number of dissected LN.


CONCLUSIONS
Our study suggests that the survival of BB women between 50-60 years of age is better compared to women in the PB generation. As more BB patients are diagnosed with EC, further research is warranted.
Department of Radiation Oncology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, U.S.A. melshai1@hfhs.org.
Mohamed A
MA
Elshaikh
Julie
J
Ruterbusch
Michele L
ML
Cote
Richard
R
Cattaneo
Adnan R
AR
Munkarah
D000230:Adenocarcinoma / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D009367:Neoplasm Staging; D011158:Population Growth; D011379:Prognosis; D018426:SEER Program; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology
Endometrial carcinoma; SEER; baby boomers; early stage; prognosis; survival