Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer.
BACKGROUND
Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).


OBJECTIVE
The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.


METHODS
A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.


RESULTS
Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04-0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.


CONCLUSIONS
Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.
Laboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas, México.
M L
ML
Martinez-Fierro
I
I
Garza-Veloz
A
A
Rojas-Martinez
R
R
Ortiz-Lopez
C
C
Castruita-de la Rosa
Y
Y
Ortiz-Castro
B P
BP
Lazalde-Ramos
A R
AR
Cervantes-Villagrana
M E
ME
Castañeda-Lopez
L
L
Gomez-Guerra
I
I
Delgado-Enciso
A A
AA
Martinez-Torres
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008800:Mexico; D008875:Middle Aged; D060787:Neoplasm Grading; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A; D017430:Prostate-Specific Antigen
Prostate cancer; VEGF; genetic susceptibility; polymorphism