Beyond cytology: why and when does the oncologist require core tissue?
There are 2 main reasons why oncologists may require additional tissue and a histologic section in addition to cytopathology from FNA specimens: improved diagnostic accuracy and molecular characterization of tumors. Rather than mutually exclusive diagnostic procedures, EUS-FNA and EUS-CNB must be viewed as supplementary techniques and both approaches should be incorporated as essential tools in the current endoscopic armamentarium.
Florida Hospital Orlando, University of Central Florida, Orlando, FL, USA.
Sebastian G
SG
de la Fuente
J Pablo
JP
Arnoletti
D014670:Ampulla of Vater; D014408:Biomarkers, Tumor / Q000378:metabolism; D062005:Biopsy, Large-Core Needle; D003138:Common Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D004067:Digestive System Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects / Q000379:methods*; D046152:Gastrointestinal Stromal Tumors / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor
Core needle biopsy (CNB); Endoscopic ultrasound (EUS); Fine-needle aspiration (FNA); Gastrointestinal stromal tumor (GIST); Lymphoma; Pancreatic cancer