Study of the complexation of oxacillin in 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers.
The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K(d)) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.
Department of Chemistry, University of Copenhagen , Thorvaldsensvej 40, DK-1871 Frederiksberg, Copenhagen, Denmark.
Jon S
JS
Hansen
Mario
M
Ficker
Johannes F
JF
Petersen
Bjarne E
BE
Nielsen
Saira
S
Gohar
Jørn B
JB
Christensen
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010068:Oxacillin / Q000008:administration & dosage* / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D050091:Dendrimers; D004337:Drug Carriers; C104700:PAMAM Starburst; D011760:Pyrrolidinones; D010068:Oxacillin