Fractionated Ocimum gratissimum leaf extract inhibit prostate cancer (PC3·AR) cells growth by reducing androgen receptor and survivin levels.
In this study, the antiproliferative activity of the organic solvent-soluble and aqueous extracts of Ocimum gratissimum leaf against the prostate cancer cells PC3·AR were evaluated by their inhibitory effects on the Androgen Receptor (AR) and Survivin protein. Two organic solvent-soluble extracts P2 and P3-2, and a water- soluble extract, PS/PT1, were found to reduce AR and Survivin levels in a time-dependent manner. In addition, extract PS/PT1, also exhibited the inhibitory activity in a dose-dependent manner. This is the first time that the inhibitory eff ects of O. gratissimum extracts have been evaluated on the Androgen Receptor (AR) and Survivin protein. The results encouraged the further studies of O. gratissimum as a potential treatment of prostate cancer.
Stephen I
SI
Ekunwe
Sakeli M
SM
Hall
Xuan
X
Luo
Hengshan
H
Wang
Gregorio B
GB
Begonia
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D031339:Ocimum / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D011471:Prostatic Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000187:drug effects* / Q000378:metabolism; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D010936:Plant Extracts; D011944:Receptors, Androgen; D000077022:Survivin