Coxsackievirus A16: epidemiology, diagnosis, and vaccine.
Coxsackievirus 16 (CA16) is one of the major pathogens associated with hand, foot, and mouth disease (HFMD) in infants and young children. In recent years, CA16 and human enterovirus 71 (EV71) have often circulated alternatively or together in the Western Pacific region, which has become an important public health problem in this region. HFMD caused by CA16 infection is generally thought to be mild and self-limiting. However, recently several severe and fatal cases involving CA16 have been reported. Studies have shown that co-infection with CA16 and EV71 can cause serious complications in the central nervous system (CNS) and increase the chance of genetic recombination, which may be responsible for the large HFMD outbreak in Mainland China in 2008. For these reasons, recent studies have focused on the virological characteristics of CA16 and the development of CA16-related diagnostic reagents and vaccines.
National Institutes for Food and Drug Control; Beijing, PR China.
Qunying
Q
Mao
National Institutes for Food and Drug Control; Beijing, PR China.
Yiping
Y
Wang
National Institutes for Food and Drug Control; Beijing, PR China.
Xin
X
Yao
National Institutes for Food and Drug Control; Beijing, PR China.
Lianlian
L
Bian
National Institutes for Food and Drug Control; Beijing, PR China.
Xing
X
Wu
National Institutes for Food and Drug Control; Beijing, PR China.
Miao
M
Xu
National Institutes for Food and Drug Control; Beijing, PR China.
Zhenglun
Z
Liang
D002681:China / Q000453:epidemiology; D019411:Clinical Laboratory Techniques / Q000379:methods; D060085:Coinfection / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D003955:Diagnostic Tests, Routine / Q000379:methods; D004196:Disease Outbreaks; D004770:Enterovirus / Q000302:isolation & purification*; D029821:Enterovirus A, Human / Q000302:isolation & purification; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*
D014765:Viral Vaccines
Coxsackievirus A16 (CA16); animal model; neutralizing antibody; recombination; vaccine