Association between IL-4 -589C>T polymorphism and colorectal cancer risk.
In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.
Proctology Department, Liaocheng People's Hospital, Liaocheng City, 252000, Shandong Province, China, li_qiangd@hotmail.com.
Qiang
Q
Li
Qian
Q
Wang
Xiaoyan
X
Xu
Songtao
S
Ren
Li
L
Wang
D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
C508598:IL4 protein, human; D015847:Interleukin-4