Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia.
Three new germacrane-type sesquiterpenoids, volvalerenal F (1), volvalerenal G (2) and volvalerenic acid D (3), along with five known compounds 4-8, were isolated from the CHCl₃ soluble partition of the ethanol extract of Valeriana officinalis var. latiofolia. The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, as well as mass spectrometry. The eight germacrane-type sesquiterpenoids showed nerve growth factor (NGF) potentiating activity, which mediates the neurite outgrowth in PC 12D cells. This study intends to reveal the chemical basis of the use of V. officinalis var. latiofolia as a dietary supplement.
Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China. dongjx@vip.sina.com.
Heng-Wen
HW
Chen
Li
L
Chen
Bin
B
Li
Hai-Long
HL
Yin
Ying
Y
Tian
Qiong
Q
Wang
Yan-Hua
YH
Xiao
Jun-Xing
JX
Dong
D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000494:pharmacology; D014632:Valerian / Q000737:chemistry*
D045788:Sesquiterpenes, Germacrane; D020932:Nerve Growth Factor