Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities.
Two new 20α-ursane-type triterpenoids (1-2) were isolated from the roots of Ilex cornuta, along with three known triterpenoids (3-5). The structures of compounds 1-2 were determined as 3β, 23-dihydroxy-20α(H)-urs-12-en-28-oic acid (1), 3β,19α,23-trihydroxy-20α(H)-urs-12-en-28-oic acid 3β-O-α-l-arabinopyranoside (2), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and high-resolution electrospray ionization mass spectrometry analyses. These pure isolates (1-5) were tested for their cytotoxic activities by MTT assay.
a College of Pharmaceutical Science, Soochow University , Suzhou , 215123 , China.
Wen-Lian
WL
Wang
Xi
X
Zhou
Yan-Li
YL
Liu
Qiong-Ming
QM
Xu
Xiao-Ran
XR
Li
Shi-Lin
SL
Yang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C587148:3beta,19alpha,23-trihydroxy-20alpha(H)-urs-12-en-28-oic acid 3beta-O-alpha-L-arabinopyranoside; C587147:3beta,23-dihydroxy-20alpha(H)-urs-12-en-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes