Cross-hetero-dehydrogenative coupling reaction of phosphites: a catalytic metal-free phosphorylation of amines and alcohols.
Phosphorylation of amines, alcohols, and sulfoximines are accomplished using molecular iodine as a catalyst and H2O2 as the sole oxidant under mild reaction conditions. This method provides an easy route for synthesizing a variety of phosphoramidates, phosphorus triesters and sulfoximine-derived phosphoramidates which are of biological importance.
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Jayaraman
J
Dhineshkumar
Kandikere Ramaiah
KR
Prabhu
D000438:Alcohols / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006861:Hydrogen Peroxide / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation
D000438:Alcohols; D000577:Amides; D000588:Amines; D009943:Organophosphorus Compounds; D010756:Phosphoric Acids; D007455:Iodine; C011067:phosphoramidic acid; D006861:Hydrogen Peroxide