When is evidence sufficient for decision-making? A framework for understanding the pace of evidence adoption.
Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption. The factors are: validity, reliability and maturity of the science available before widespread adoption; communication of the science; economic drivers; patients' and physicians' ability to apply published scientific findings to their specific clinical needs; and incorporation into practice guidelines.
National Pharmaceutical Council, 1717 Pennsylvania Avenue, NW, Suite 800, Washington, DC 20006, USA. rdubois@npcnow.org.
Robert W
RW
Dubois
Michael
M
Lauer
Eleanor
E
Perfetto
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000639:trends; D001943:Breast Neoplasms / Q000628:therapy; D023921:Coronary Stenosis / Q000628:therapy; D003657:Decision Making; D004059:Diffusion of Innovation; D054855:Drug-Eluting Stents / Q000639:trends; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D057170:Translational Research, Biomedical
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors