Gender difference in relationship between body mass index and development of chronic kidney disease.
BACKGROUND
An epidemiological approach to preventing the development or progression of chronic kidney disease (CKD) is necessary, while few effective preventive measures are currently available. We conducted a community-based, cohort study to identify the factors associated with the development of CKD in the general population.


METHODS
We examined 1876 local residents of a Japanese community who had an annual health check-up and, of those, 1506 residents judged not to have CKD (473 men and 1033 women) were followed for the development of CKD over 10 years.


RESULTS
The numbers of male and female residents who developed CKD during the follow-up period were 167 (35.3%) and 299 (28.9%), respectively. As compared to those without CKD development, the residents who developed CKD were older, and had a higher body mass index (BMI), systolic blood pressure, and creatinine in both genders. The rate of CKD development in obese female residents was higher than in non-obese women, but such a difference was not noted in male residents. In addition to age and serum creatinine, we identified BMI as an independently significant factor for the development of CKD in women, but not in men.


CONCLUSIONS
Increased BMI is a significant risk factor for the development of CKD in women, and there seems to be a gender difference in the association between increased BMI and the development of CKD in the general population.
Hiroshi
H
Komura
Ikuo
I
Nomura
Kazuo
K
Kitamura
Kenji
K
Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. jkjpn@med.miyazaki-u.ac.jp.
Johji
J
Kato
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors; D012737:Sex Factors
D003404:Creatinine