[Corneal reepithelialization time with instillation of eye drops containing sodium hyaluronate and carboxymethylcellulose].
OBJECTIVE
Evaluate the time of post-abrasion corneal re-epithelialization using commercially available eye drops, one of which containing 0.4% sodium hialuronate, and the other containing 1% carboxymethylcellulose, and compare them to the re-epithelialization without the drops.


METHODS
24 rabbits were used, which had the mechanical abrasion of the central 8 mm of their corneas done. These animals were divided in 3 groups. The first one received the drops containing 0.4% of sodium hialuronate, the second one received the drops containing 1% of carboxymethylcellulose and the third group did not receive any drugs. The evaluations took place every 24 hours through the analysis of digital pictures under cobalt blue light and coloring of the corneas with 2% fluorescein. The pictures were analyzed with the software Autocad 2009®. The data was analyzed through the comparison of the total re-epithelialization time among the three groups


RESULTS
The time of total re-epithelialization of the group using sodium hialuronate was on average 90 hours and the group using carboxymethylcellulose 105 hours, while the group using no drugs was 108 hours. There was a better performance of those groups using the drops and this difference can be proved statistically.


CONCLUSIONS
The drops containing 0.4% of sodium hialuronate showed a higher efficiency rate compared to the drops containing 1% of carboxymethylcellulose, which was higher than the control group. The results of the present study show that the use of lubricants in the process of re-epithelialization are extremely valid and must be used frequently in ophthalmologic clinic.
Luciane Bugman
LB
Moreira
Rochelli
R
Scalco
Silvia
S
Hara
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D003315:Cornea / Q000166:cytology; D065306:Corneal Injuries; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011446:Prospective Studies; D011817:Rabbits; D062326:Re-Epithelialization / Q000187:drug effects*; D013997:Time Factors; D055675:Viscosupplements / Q000627:therapeutic use*
D009883:Ophthalmic Solutions; D055675:Viscosupplements; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium