Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China.
This study investigated the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity. A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. At each hospital, Chinese T2DM patients with central obesity who were aged over 20 years, whose serum uric acid levels were measured, and who had lived in Guangdong Province for >=1 year, were recruited. Hyperuricemia was defined as serum uric acid >420 μmol/L in men and >360 μmol/L in women. Binary logistic regression was used to assess associated risk factors for hyperu-ricemia. A total of 2,917 T2DM patients with central obesity took part. The overall prevalence of hyperuricemia was 32.6% (36.1% for women, 28.4% for men). Binary logistic regression analyses demonstrated that women (OR: 1.576; 95% confidence interval (CI): 1.231, 2.018), high BMI (OR: 1.228; 95% CI: 1.094, 1.379), waist cir-cumference (OR: 1.135; 95% CI: 1.009, 1.276), hypertension (OR: 1.603; 95% CI: 1.263, 2.035), high total cho-lesterol (OR: 1.133; 95% CI: 1.002, 1.281), triglycerides (OR: 1.134; 95% CI: 1.069, 1.203), low HDL-cholesterol (OR: 0.820; 95% CI: 0.677, 0.995) and low estimated glomerular filtration rate (OR: 0.840; 95% CI: 0.815, 0.866) were risk factors associated with hyperuricemia. Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR.
Department of Endocrinology, Zhujiang Hospital, Southern Medical University, 253# industry road, 510282, Guangzhou, Guangdong, China. dehongcaizj@163.com.
Jiao
J
Wang
Rong-Ping
RP
Chen
Lei
L
Lei
Qing-Qing
QQ
Song
Ru-Yi
RY
Zhang
Yan-Bing
YB
Li
Chuan
C
Yang
Shao-Da
SD
Lin
Li-shu
LS
Chen
Yu-Lin
YL
Wang
Fan
F
Zhao
Gan-Xiong
GX
Liang
Bao-Chun
BC
Hu
Jian-Cai
JC
Lin
De-Hong
DH
Cai
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006761:Hospitals; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology* / Q000209:etiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications*; D012307:Risk Factors; D012737:Sex Factors; D055105:Waist Circumference
D008055:Lipids