A common origin for guanidinobutanoate starter units in antifungal natural products.
Keeping it basic: Arginine provides the exotic 4-guanidinobutanoate starter unit for two different types of zwitterionic polyketide (an example for one type is shown in the picture) produced by the same Streptomyces bacterium. The three-step precursor pathway is initiated by a remarkable decarboxylating monooxygenase with high specificity for arginine.
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (UK). hh230@cam.ac.uk.
Hui
H
Hong
Taicia
T
Fill
Peter F
PF
Leadlay
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011090:Polyenes / Q000737:chemistry* / Q000494:pharmacology
D000935:Antifungal Agents; D001688:Biological Products; D006146:Guanidines; D011090:Polyenes
antibiotics; biosynthesis; guanidine; macrocyclic polyketides; polyene