[Association between polymorphism of FOXA1 gene and type 2 diabetes].
OBJECTIVE
To detect the relationship between FOXA1 gene polymorphism and type 2 diabetes mellitus (T2DM).


METHODS
The techniques of mass chromatographic analysis were used to detect the polymorphism of FOXA1 gene in 190 patients with T2DM and 193 healthy control persons without T2DM. We used the software SPSS 13.0 for statistical analysis.


RESULTS
There was no significant difference between the case and control group about sex and age distribution. The distribution of genotypic frequency in control group consistented with the Hardy-Weinberg law. The frequency of the TT, TC and CC genotype in case were 76.5%, 19.3% and 4.3%. The frequency of the TT, TC and CC genotype in control were 78.1%, 20.3% and 1.6%. There was no significant difference between the case and control group about genotype frequency (chi2 = 2.49, P = 0.287). There may be no significant difference between the TC, TG, HDL-C, LDL-C level and genotypes of rs7144658 in mutant.


CONCLUSIONS
There may be no significant relationship between the polymorphism of FOXA1 gene and T2DM. Genic mutation on rs7144658 may not affect the lipid level in type 2 diabetics.
Department of Epidemiology and Health Statistics, School of Public Health, Jilin University,Changchun 130021,China. lvle2009wl@126.com
Le
L
Lü
Yong
Y
Li
Yichun
Y
Qiao
Yuan
Y
Tang
Zhihui
Z
Yan
Yi
Y
Cheng
Yawen
Y
Liu
D000368:Aged; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide
C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha