Polyclonal antibody targeting SOX11 cannot differentiate mantle cell lymphoma from B-cell non-Hodgkin lymphomas.
OBJECTIVE
To determine whether SOX11 is a diagnostic marker of mantle cell lymphoma (MCL).


METHODS
We analyzed SOX11 expression in 349 B-cell non-Hodgkin lymphomas (B-NHLs) via immunohistochemistry.


RESULTS
Nuclear staining of SOX11 was observed in 54 (93.1%) of 58 MCLs. We noticed that SOX11 protein was also expressed on the nuclei in 8 (21.6%) of 37 B-lymphoblastic lymphomas, 45 (32.6%) of 138 diffuse large B-cell lymphomas, 15 (44.1%) of 34 follicular lymphomas, 8 (30.8%) of 26 Burkitt lymphomas, 2 (10.0%) of 20 chronic lymphocytic leukemia/small cell lymphomas, and 3 (18.8%) of 16 marginal zone lymphomas.


CONCLUSIONS
Although the positive rate of SOX11 expression in MCL was significantly higher than other B-NHLs (P < .001), polyclonal antibody targeting SOX11 is not able to identify MCL from B-NHLs because the nuclear staining of SOX11 was widely positive in B-NHLs.
Dept of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China; xuwei10000@hotmail.com.
Li-Na
LN
Zhang
Xin
X
Cao
Ting-Xun
TX
Lu
Lei
L
Fan
Li
L
Wang
Ji
J
Xu
Run
R
Zhang
Zhi-Jian
ZJ
Zou
Jia-Zhu
JZ
Wu
Jian-Yong
JY
Li
Wei
W
Xu
D000906:Antibodies; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000378:metabolism; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000378:metabolism; D055751:SOXC Transcription Factors / Q000032:analysis* / Q000096:biosynthesis
D000906:Antibodies; D014408:Biomarkers, Tumor; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors
B-cell non-Hodgkin lymphoma; Immunohistochemistry; Mantle cell lymphoma; Polyclonal antibody; SOX11