Antidepressant-induced sexual dysfunction in men.
Most of the available antidepressant medications, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and dual noradrenergic/serotonergic reuptake inhibitors have been reported to be associated with sexual dysfunction in both sexes. This manuscript reviews evidence concerning the relative incidence of treatment emergent sexual dysfunction in men being treated with antidepressant drugs. Both double-blind controlled trials and large clinical series report a high incidence of sexual dysfunction, especially ejaculatory delay, with serotonergic drugs. The incidence of sexual dysfunction in men appears to be much lower with drugs whose primary mechanism of action involves adrenergic or dopaminergic systems.
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: Rsegraves3@hotmail.com.
Robert Taylor
RT
Segraves
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA; Department of Anesthesiology, Wayne State University School of Medicine, Detroit, MI, USA.
Richard
R
Balon
D000928:Antidepressive Agents / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D018849:Controlled Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology; D004542:Ejaculation / Q000187:drug effects; D006801:Humans; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors
Antidepressant; Serotonin; Sexual disorder; Sexual dysfunction; Side effect