An efficient palladium-catalyzed C-H alkoxylation of unactivated methylene and methyl groups with cyclic hypervalent iodine (i(3+) ) oxidants.
All the hype: The title reaction has been developed for the facile synthesis of a variety of complex alkyl ethers. Cyclic hypervalent iodine (I(3+) ) reagents serve as oxidants for this unique CH alkoxylation reaction. The reaction demonstrates excellent reactivity, good functional-group tolerance, and high yields. Q=8-aminoquinoline-derived auxiliary.
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (China).
Gang
G
Shan
Xinglin
X
Yang
Yu
Y
Zong
Yu
Y
Rao
D002384:Catalysis; D007455:Iodine / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D016877:Oxidants; D010165:Palladium; D007455:Iodine
CH activation; hypervalent compounds; iodine; oxidation; palladium