Stroke induced Sarcopenia: muscle wasting and disability after stroke.
Stroke is the second leading cause of death and the leading cause of disability in Western countries. More than 60% of patients remain disabled, 50% of patients suffer from hemiparesis and 30% remain unable to walk without assistance. The skeletal muscle is the main effector organ accountable for disability in stroke. This disability is primarily attributed to the brain lesion; however less attention is paid to structural, metabolic and functional alterations of muscle tissue after stroke. Hemiparetic stroke leads to various muscle abnormalities: A combination of denervation, disuse, inflammation, remodelling and spasticity accounts for a complex pattern of muscle tissue phenotype change and atrophy. The molecular mechanisms of muscle degradation after stroke are only incompletely understood. Reinnervation, fibre-type shift, disuse atrophy, and local inflammatory activation are only some of the key features yet to be explained. Only limited data is available today on clinical muscle changes after stroke that results from few studies in a mere 500 patients. Despite its importance for optimum post stroke recovery, stroke-related sarcopenia is not considered in current guidelines for stroke therapy or rehabilitation and measurement tools to address sarcopenia are infrequently used. This lack of robust evidence on muscle pathology after stroke and on treatment strategies needs to be addressed in an interdisciplinary integrated approach. This review provides an overview on current pathophysiologic insights and on clinical relevance of sarcopenia in stroke patients and on measurement tools to address the problem in the clinical setting.
Centre for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany.
Nadja
N
Scherbakov
Stephan
S
von Haehling
Stefan D
SD
Anker
Ulrich
U
Dirnagl
Wolfram
W
Doehner
D004185:Disability Evaluation; D006801:Humans; D009133:Muscular Atrophy / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D055948:Sarcopenia / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D020521:Stroke / Q000150:complications*; D015431:Weight Loss
Body weight loss; Catabolic activation; Sarcopenia; Stroke