Concurrent chemoradiotherapy for non-bulky stage IB/II cervical cancer without pelvic node enlargement.
BACKGROUND
Concurrent chemoradiotherapy (CCRT) has not been extensively studied in patients with small cervical cancer tumors with no pelvic node enlargement.


METHODS
We retrospectively analyzed 55 patients with stage IB1-IIB cervical cancer and tumors of ≤40 mm with no pelvic node enlargement treated with radiotherapy (RT)-alone.


RESULTS
Cancer recurred in seven patients. Patient age (≤63 years) was identified as an independent factor for better disease-free survival (DFS) (p=0.027), and tumor size (≥25 mm) had a tendency to correlate with reduced locoregional DFS (p=0.089) by the Cox hazard model. Among patients aged 63 years or less, cancer recurred in five out of 18 patients with tumors of ≥25 mm, but in only one of 10 patients with tumors of ≤24 mm.


CONCLUSIONS
In patients with stage IB1-IIB cervical cancer and small tumors with no node enlargement, CCRT may provide a better disease control for the group aged 63 years or less and with tumor size of 25 mm or more.
Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara Nishihara, Okinawa 903-0215, Japan. yoichi@med.u-ryukyu.ac.jp.
Akihiko
A
Wakayama
Morihiko
M
Inamine
Wataru
W
Kudaka
Yutaka
Y
Nagai
Tomoko
T
Nakamoto
Takuma
T
Ooyama
Takuro
T
Ariga
Goro
G
Kasuya
Takafumi
T
Toita
Yoichi
Y
Aoki
D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000628:therapy; D009367:Neoplasm Staging; D010388:Pelvis / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
Non-bulky; cervical cancer; concurrent chemoradiotherapy; radiotherapy; stage IB1/II