[Chemical constituents from the aerial part of Echinacea purpurea].
OBJECTIVE
To study the chemical constituents of the aerial part of Echinacea purpurea.


METHODS
The compounds were separated and purified by repeatedly silica gel, ODS, D101 macroporous resin, MCI, Sephadex LH-20 column chromatography and recrystallization. Their structures were elucidated on the basis of physiochemical properties and spectral analysis.


RESULTS
Sixteen compounds were isolated and identified as (2S)-1-O-octacosanoyl glycerol (1), (5R,6S)-6-hydroxy-6-((E)-3-hydroxybut-1-enyl)-1,1, 5-trimethylcyclohexanone (2), (3S, 6E, 10R)-3, 10, 11-trihydroxy-3, 7, 11-trimethyl-dodeca-1, 6-diene (3), negunfurol (4), schensianol A (5), ent-4 (15) -eudesmene-1beta, 6alpha-diol (6), (E) -5-hydroxy-N-isobutylpentadec-2-enamide (7), syringaresinol (8), quercetin (9), ethyl laurate (10), ethyl caffeate (11), ferulic acid (12), alpha-spinasterol (13), stigmasterol (14), beta-daucosterol (15), octacosanoic acid (16).


CONCLUSIONS
Compound 1 - 5 are isolated from the Asteraceae for the first time, compound 6 ,7, 9, 10, 12 are isolated from genus of Echinacea for the first time, compound 15, 16 are isolated from this plant for the first time.
Faculty of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China. chenqiulingcql@126.com
Qiu-Ling
QL
Chen
Lei
L
Wang
Feng
F
Feng
D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D020900:Echinacea / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D005227:Fatty Acids; C068792:octacosanoic acid