[Chemical constituents of chloroform fraction from leaves of Chimonanthus salicifolius].
To explore anti-tumor active components of Chimonanthus salicifolius, the phytochemistry of the chloroform fraction from leaves extract was investigated by repeated silica gel column chromatography. Twelve compounds were isolated and their structures were identified by physicochemical properties and spectroscopic data analysis as 9-epi-blumenol C(1), blumenol C(2), (+)-dehydrovomifoliol (3), (+)-vomifoliol (4), robinlin (5), (-)-loliolide (6), isofraxidin (7), scopoletin (8), 6,7-dimethoxycoumarin (9), 6, 7, 8-trimethoxycoumarin (10), beta-sitostenone (11), and beta-stigmasterol(12). Compounds 1-6 belonging to nor-sesquiterpenoids were isolated from the family Calycanthaceae for the first time. Compound 1 was a new natural product. Compounds 7, 11 and 12 were obtained from this plant for the first time.
School of Pharmacy, Fudan Univerisity, Shanghai 201203, China.
Yao
Y
Zhang
Jin-Wei
JW
Hua
Xiu-Yan
XY
Wang
Wen-Liang
WL
Cheng
Hou-Xing
HX
Lei
Ke-Jun
KJ
Cheng
Pei-Zhong
PZ
Yu
D000970:Antineoplastic Agents / Q000032:analysis* / Q000302:isolation & purification; D031237:Calycanthaceae / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D002725:Chloroform