Effect of diclofenac on the pharmacokinetics of moxifloxacin in rats.
A sensitive and specific method was developed and validated for the determination of moxifloxacin in plasma using HPLC. The effect of diclofenac (12.5, 25, 50 mg/kg) on the pharmacokinetics of orally administered moxifloxacin (40 mg/kg) in rats was investigated. Pharmacokinetic parameters of moxifloxacin were determined in rats following oral administration to rats in the presence and absence of diclofenac. The coadministration of the 2 drugs resulted in 10~29.5% decrease of the AUC and a 24.7~34% decrease of t1/2 for moxifloxacin; Tmax for moxifloxacin was 1.41~1.9-fold higher than that after the administration of moxifloxacin alone; Cmax for moxifloxacin decreased by 20.5~49%, as compared to that after the administration of moxifloxacin alone. Consequently, moxifloxacin and diclofenac should be monitored closely for potential drug interactions.
Department of Pediatrics of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
L
L
Chen
Department of Pediatrics of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
S
S
Guo
Department of Pediatrics of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
M
M
Xu
Department of Pediatrics of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
L-X
LX
Wu
Department of Pediatrics of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
J-H
JH
Zhang
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004008:Diclofenac / Q000494:pharmacology*; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D000077266:Moxifloxacin; D051381:Rats; D017207:Rats, Sprague-Dawley
D024841:Fluoroquinolones; D004008:Diclofenac; D000077266:Moxifloxacin