Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives.
A series of novel 1,3-selenazole-containing 1,3,4-thiadiazole derivatives bearing Schiff base moieties were synthesized and evaluated for their in vitro antiproliferative activities against human breast cancer cell MCF-7 and mouse lymphocyte leukemia cell L1210 by CCK-8 assay. The majority of the compounds showed better activity against MCF-7 cell, compared with lead compound PCS. In particular, compound 6c was the most potent compound with IC50 value of 4.02 μM.
Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
Hai-Chuan
HC
Zhao
Yan-Ping
YP
Shi
Yu-Ming
YM
Liu
Cai-Wen
CW
Li
Li-Na
LN
Xuan
Peng
P
Wang
Kai
K
Zhang
Bao-Quan
BQ
Chen
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole
1,3,4-Thiadiazole derivatives; 1,3-Selenazole; Antitumor agents; Schiff base