Comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: a randomized, controlled trial.
OBJECTIVE
Despite the benefits of endoscopic nasobiliary drainage (NBD) in endoscopic retrograde cholangiopancreatography (ERCP), post-ERCP pancreatitis (PEP) and nose/throat discomfort can result. We aimed to determine whether the use of a smaller catheter alleviates these complications.


METHODS
A randomized, controlled trial at a tertiary care center compared 4 Fr and 6 Fr NBD catheters; 165 ERCP patients with naïve papillae were randomly assigned to a catheter-size group.


RESULTS
The prevalence of PEP was significantly lower in the 4 Fr group (3.7%; 3/82) than in the 6 Fr group (15.7%; 13/83; P = 0.019). No spontaneous catheter displacement occurred within 24 h. Discomfort visual analog scores were 2.6 and 4.3 in the 4 Fr and 6 Fr groups, respectively (P = 0.0048) on procedure day; on the following day, the scores were 2.3 and 3.6 (P = 0.028). Bile output was 16.3 mL/h and 21.4 mL/h in the 4 Fr and 6 Fr groups (P = 0.051). On obstructive jaundice subgroup analysis, bile drainage was 19.2 mL/h and 22.1 mL/h in the 4 Fr and 6 Fr groups (P = 0.40). The 4 Fr group required 5.6 days to reduce bilirubin levels versus 6.1 days in the 6 Fr group (P = 0.51).


CONCLUSIONS
In patients with naïve papillae, lower rates of PEP and less nose/throat discomfort are associated with the use of 4 Fr NBD catheters. In patients with obstructive jaundice, 4 Fr and 6 Fr catheters are comparable with regard to bile output and bilirubin level reduction.
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Takashi
T
Ishigaki
Tamito
T
Sasaki
Masahiro
M
Serikawa
Tomoyuki
T
Minami
Akihito
A
Okazaki
Masanobu
M
Yukutake
Yasutaka
Y
Ishii
Keiichi
K
Kosaka
Teruo
T
Mouri
Satoshi
S
Yoshimi
Kazuaki
K
Chayama
D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D057785:Catheters; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects / Q000295:instrumentation; D004322:Drainage / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D015995:Prevalence; D011446:Prospective Studies; D016896:Treatment Outcome
D001663:Bilirubin
endoscopic retrograde cholangiopancreatography; post-endoscopic retrograde cholangiopancreatography pancreatitis; visual analog scale