Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.
Macrophage migration inhibitory factor (MIF), a cytokine involved in the pathogenesis of sepsis, diabetes, asthma, arthritis, and cancer, has an enzymatic active site that has proven to be an effective target for small molecule-based inhibitors. Herein, we describe the synthesis of a novel arylazoarylmethane compound (3) from a known arylhydrazone MIF inhibitor (2). This new compound has improved stability and in vivo biological activity.
Center for Molecular Innovation, Manhasset, NY, USA.
Mingzhu
M
He
Christine
C
Metz
Kai Fan
KF
Cheng
Jie
J
Ling
Thomas
T
Coleman
Sonya
S
VanPatten
Yousef
Y
Al-Abed
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D015195:Drug Design; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D019746:Intramolecular Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D006835:Hydrazones; D008263:Macrophage Migration-Inhibitory Factors; D002351:Carrageenan; D019746:Intramolecular Oxidoreductases; C076231:Mif protein, mouse
Arylazoarylmethane; Arylhydrazone; Inflammation; Macrophage migration inhibitory factor