Role of extracellular matrix and YAP/TAZ in cell fate determination.
The mechanical signals transduced from cellular microenvironment can regulate cell shape and affect cell fate determination. However, how these mechanical signals are transduced to regulate biological processes of cells has remained elusive. Recent studies had elucidated a novel mechanism through which the interactions between mechanical signals from extracellular matrix and cell behavior regulation converged on the function of core components in Hippo signaling pathway, including YAP and TAZ in mammals. Moreover, several very recent studies have found a new crosstalk between Wnt and Hippo signaling in the regulation of cell fate determination. Such mechanism may explain how mechanical signals from microenvironment can regulate cell behavior and determine cell fate.
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Jin
J
Hao
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Yueling
Y
Zhang
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Yating
Y
Wang
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Rui
R
Ye
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Jingyi
J
Qiu
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Zhihe
Z
Zhao
Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: lijuan@scu.edu.cn.
Juan
J
Li
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D014157:Transcription Factors; D051153:Wnt Proteins; D017346:Protein Serine-Threonine Kinases
Extracellular matrix; Hippo signaling; Mechanotransduction; Wnt; YAP/TAZ