A new flavonoid from the aerial parts of Andrographis paniculata.
A new flavonoid, 7,8-dimethoxy-2'-hydroxy-5-O-β-d-glucopyranosyloxyflavone (1), along with 15 known flavonoids (2-16), was isolated from the aerial parts of Andrographis paniculata Nees. Their structures were elucidated on the basis of chemical and spectroscopic analyses. Most of them have uncommon O-substitution patterns involving 5-, 7-, 8-, 2'-, 3'-, 4'- and 5'-O-substituents. The antiproliferative effects of these flavonoids against human leukaemia HL-60 cells were investigated. Among them, 13 was the most active, displaying potent antiproliferative activity with IC50 of 3.50 μM. The structure-activity relationships of these isolated compounds were discussed.
a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
Li-Xia
LX
Chen
Hao
H
He
Gui-Yang
GY
Xia
Kai-Lan
KL
Zhou
Feng
F
Qiu
D035685:Andrographis / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C000590957:7,8-dimethoxy-2'-hydroxy-5-O-beta-D-glucopyranosyloxyflavone; D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D005960:Glucosides; C043562:flavone