Depression, C-reactive protein and length of post-operative hospital stay in coronary artery bypass graft surgery patients.
This study aimed to explore the role of C-reactive protein (CRP) in mediating the association between greater pre-operative depression symptoms and longer post-operative length of stay in patients undergoing coronary artery bypass graft (CABG) surgery. We used a sample of 145 elective CABG patients and measured depression symptoms using the Beck Depression Inventory (BDI) prior to surgery and collected baseline measures of CRP. Participants were followed up during their in-hospital stay to measure early (1-3 days post-surgery) and persistent (4-8 days post-surgery) CRP responses to surgery. We found that compared with participants with low depression symptoms, those with elevated depression symptoms (BDI>10) prior to CABG were at increased odds of a hospital stay of greater than one week (OR 3.51, 95% CI 1.415-8.693, p=0.007) and that greater persistent CRP responses mediated this association. Further work is needed to explore the exact physiological pathways through which depression and CRP interact to affect recovery in CABG patients.
Department of Epidemiology and Public Health, University College London, 1-19 TorringtonPlace, London, WC1E 6BT. Electronic address: lydia.poole.09@ucl.ac.uk.
Lydia
L
Poole
Department of Epidemiology and Public Health, University College London, 1-19 TorringtonPlace, London, WC1E 6BT.
Tara
T
Kidd
Department of Epidemiology and Public Health, University College London, 1-19 TorringtonPlace, London, WC1E 6BT; Department of Cardiac Surgery, St. George's Hospital, University of London, Blackshaw Road, London, SW17 0QT.
Elizabeth
E
Leigh
Department of Epidemiology and Public Health, University College London, 1-19 TorringtonPlace, London, WC1E 6BT; Department of Cardiac Surgery, St. George's Hospital, University of London, Blackshaw Road, London, SW17 0QT.
Amy
A
Ronaldson
Department of Cardiac Surgery, St. George's Hospital, University of London, Blackshaw Road, London, SW17 0QT.
Marjan
M
Jahangiri
Department of Epidemiology and Public Health, University College London, 1-19 TorringtonPlace, London, WC1E 6BT.
Andrew
A
Steptoe
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000523:psychology*; D003863:Depression / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged
D002097:C-Reactive Protein
C-reactive protein; Coronary artery bypass grafting; Depression; Recovery