One-pot synthesis of 7,9-dialkylpurin-8-one analogues: broad substrate scope.
The one-pot and direct synthesis of 7,9-dialkylpurin-8-one analogues with broad substrate scope has been developed. This copper-catalyzed C-H oxidation reaction could avoid multistep synthesis of quaternary ammonium salts and expand the scope of halogenated alkanes. Moreover, benzimidazole derivatives are also applicable in the catalytic system.
School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University , Xinxiang 453007, Henan, China.
Jian-Ping
JP
Li
Yu
Y
Huang
Ming-Sheng
MS
Xie
Gui-Rong
GR
Qu
Hong-Ying
HY
Niu
Hai-Xia
HX
Wang
Bo-Wen
BW
Qin
Hai-Ming
HM
Guo
D000473:Alkanes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry
D000473:Alkanes; D007454:Iodides; D011687:Purines; D000644:Quaternary Ammonium Compounds; D003300:Copper; C073870:cuprous iodide