Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy.
Electrographic seizures are seizures that are evident on EEG monitoring. They are common in critically ill children and neonates with acute encephalopathy. Most electrographic seizures have no associated clinical changes, and continuous EEG monitoring is necessary for identification. The effect of electrographic seizures on outcome is the focus of active investigation. Studies have shown that a high burden of electrographic seizures is associated with worsened clinical outcome after adjustment for cause and severity of brain injury, suggesting that a high burden of such seizures might independently contribute to secondary brain injury. Further research is needed to determine whether identification and management of electrographic seizures reduces secondary brain injury and improves outcome in critically ill children and neonates.
Departments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: abend@email.chop.edu.
Nicholas S
NS
Abend
Courtney J
CJ
Wusthoff
Ethan M
EM
Goldberg
Dennis J
DJ
Dlugos
D000293:Adolescent; D000818:Animals; D001925:Brain Damage, Chronic / Q000209:etiology; D001927:Brain Diseases / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D004569:Electroencephalography / Q000379:methods; D005544:Forecasting; D006330:Heart Defects, Congenital / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008991:Monitoring, Physiologic; D064887:Observational Studies as Topic; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D013226:Status Epilepticus / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D063189:Symptom Assessment