The lectin ERGIC-53 goes viral.
The biosynthesis of fusion-competent envelope glycoproteins (GPs) is a crucial step in productive viral infection. In this issue, Klaus et al. (2013) identify the cargo receptor endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein (ERGIC-53) as a binding partner for viral GPs and a crucial cellular factor required for infectious virus production.
Institute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
Antonella
A
Pasquato
Stefan
S
Kunz
D018050:Arenavirus / Q000502:physiology*; D017934:Coronavirus / Q000502:physiology*; D016563:Filoviridae / Q000502:physiology*; D006801:Humans; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D019065:Virus Assembly
C084004:LMAN1 protein, human; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins