Two for all: receptor-associated kinases SOBIR1 and BAK1.
Leucine-rich repeat-receptor-like proteins (LRR-RLPs) are ubiquitous cell surface receptors lacking a cytoplasmic signalling domain. For most of these LRR-RLPs, it remained enigmatic how they activate cellular responses upon ligand perception. Recently, the LRR-receptor-like kinase (LRR-RLK) SUPPRESSOR OF BIR1-1 (SOBIR1) was shown to be essential for triggering defence responses by certain LRR-RLPs that act as immune receptors. In addition to SOBIR1, the regulatory LRR-RLK BRI1-ASSOCIATED KINASE-1 (BAK1) is also required for LRR-RLP function. Here, we compare the roles of SOBIR1 and BAK1 as regulatory LRR-RLKs in immunity and development. BAK1 has a general regulatory role in plasma membrane-associated receptor complexes comprising LRR-RLPs and/or LRR-RLKs. By contrast, SOBIR1 appears to be specifically required for the function of receptor complexes containing LRR-RLPs.
Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands; Centre for BioSystems Genomics, Droevendaalsesteeg 1, 6700 AB Wageningen, The Netherlands.
Thomas W H
TW
Liebrand
Molecular Plant Pathology, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
Harrold A
HA
van den Burg
Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands; Centre for BioSystems Genomics, Droevendaalsesteeg 1, 6700 AB Wageningen, The Netherlands. Electronic address: Matthieu.Joosten@wur.nl.
Matthieu H A J
MH
Joosten
D029681:Arabidopsis Proteins / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D010944:Plants / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D029681:Arabidopsis Proteins; D011494:Protein Kinases; C463660:BAK1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases
development; genome collinearity; innate immunity; receptor-like protein; regulatory receptor-like kinase