Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications.
Gold nanoparticles (AuNPs) can be readily synthesized and modified with chemical and biological molecules, making them attractive inorganic biomaterials for drug delivery and molecular diagnostics. The surface of AuNPs supports the efficient attachment of various biomacromolecules via chemisorption, chemical conjugation and electrostatic interaction. Based on advantages of facile surface modification and unique optical properties, AuNPs have been extensively used as drug carriers for the intracellular delivery of therapeutics as well as molecular nanoprobes for detection and monitoring of the target molecules of interest. In this review, we highlight advanced approaches in the biomedical applications of AuNPs such as gene and drug therapy, molecular diagnostics and imaging.
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea.
Eun Hye
EH
Jeong
Giyoung
G
Jung
Cheol Am
CA
Hong
Hyukjin
H
Lee
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000295:instrumentation*; D018014:Gene Transfer Techniques / Q000295:instrumentation; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation* / Q000379:methods; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods; D050997:Nanomedicine / Q000295:instrumentation* / Q000379:methods; D011237:Predictive Value of Tests; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods
D000970:Antineoplastic Agents; D004337:Drug Carriers; D006046:Gold