Multiple myeloma: relationship to antioxidant esterases.
OBJECTIVE
To investigate the status of the oxidant/antioxidant balance in patients with multiple myeloma compared to healthy controls.


METHODS
This study was conducted on 40 multiple myeloma patients and 40 healthy controls of matched age and sex. Serum total thiol, oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS) were measured using colourimetric methods; paraoxonase-1 and arylesterase enzyme activities were also quantified.


RESULTS
Serum paraoxonase-1 and arylesterase activities and total thiol levels were significantly lower (p = 0.0001, p = 0.036 and p < 0.0001, respectively), whereas TOS and OSI levels were significantly higher (p < 0.0001 for both parameters) in multiple myeloma patients compared to controls. However, no significant differences in TAS were identified when the two groups were compared.


CONCLUSIONS
Our findings indicate an impaired oxidative/antioxidative balance in multiple myeloma. We recommend further studies with larger groups to investigate the possible relationship between oxidative stress and the aetiopathogenesis of multiple myeloma.
Central Laboratories of Antalya Education and Research Hospital, Antalya, Turkey.
Hamit Yasar
HY
Ellidag
Esin
E
Eren
Ozgur
O
Aydin
Mustafa
M
Yıldırım
Cem
C
Sezer
Necat
N
Yilmaz
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000097:blood* / Q000378:metabolism; D004950:Esterases / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000097:blood
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase