Chin tremors associated with paroxetine in a patient with pancreatic adenocarcinoma.
BACKGROUND
There have been many cases of medication-induced tremors. We report a patient who developed significant chin tremors after the administration of paroxetine.


METHODS
A 68-year-old Vietnamese female with a past medical history including GIST and pancreatic cancer status post Whipple procedure and six months of adjuvant chemotherapy with gemcitabine presented with symptoms of anxiety for which she was treated with paroxetine. Within 2 weeks she developed chin tremors which resolved after paroxetine was discontinued.


CONCLUSIONS
To our knowledge, this is the first case report of a temporary chin tremor associated with paroxetine. The exact mechanism of this phenomenon is unclear. However, it has been suggested that movement disorders such as chin tremors may be related to elevated serotonin levels causing an inhibition of central dopamine.
Department of Internal Medicine, Tufts Medical Center. Boston, MA, USA. pjohn@tuftsmedicalcenter.org.
Preethi
P
John
Kathleen
K
McConnell
Muhammad Wasif
MW
Saif
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D002680:Chin; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D017374:Paroxetine / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D014202:Tremor / Q000139:chemically induced*; D028761:Withholding Treatment; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D000093542:Gemcitabine