Centrifugal blood pump for temporary ventricular assist devices with low priming and ceramic bearings.
A new model of centrifugal blood pump for temporary ventricular assist devices has been developed and evaluated. The design of the device is based on centrifugal pumping principles and the usage of ceramic bearings, resulting in a pump with reduced priming (35 ± 2 mL) that can be applied for up to 30 days. Computational fluid dynamic (CFD) analysis is an efficient tool to optimize flow path geometry, maximize hydraulic performance, and minimize shear stress, consequently decreasing hemolysis. Initial studies were conducted by analyzing flow behavior with different impellers, aiming to determine the best impeller design. After CFD studies, rapid prototyping technology was used for production of pump prototypes with three different impellers. In vitro experiments were performed with those prototypes, using a mock loop system composed of Tygon tubes, oxygenator, digital flow meter, pressure monitor, electronic driver, and adjustable clamp for flow control, filled with a solution (1/3 water, 1/3 glycerin, 1/3 alcohol) simulating blood viscosity and density. Flow-versus-pressure curves were obtained for rotational speeds of 1000, 1500, 2000, 2500, and 3000 rpm. As the next step, the CFD analysis and hydrodynamic performance results will be compared with the results of flow visualization studies and hemolysis tests.
Dante Pazzanese Institute of Cardiology, São Paulo, São Paulo, Brazil.
Juliana
J
Leme
Cibele
C
da Silva
Jeison
J
Fonseca
Bruno Utiyama
BU
da Silva
Beatriz
B
Uebelhart
José F
JF
Biscegli
Aron
A
Andrade
D002498:Centrifugation; D002516:Ceramics / Q000737:chemistry; D006353:Heart-Assist Devices / Q000009:adverse effects; D006461:Hemolysis; D006801:Humans; D057446:Hydrodynamics; D011474:Prosthesis Design
Blood pump; Centrifugal pump; Temporary ventricular assist device