Exclusion of influences of ARMS2 polymorphisms on the central visual field in retinitis pigmentosa.
OBJECTIVE
To investigate the effects of polymorphisms of the age-related maculopathy susceptibility 2 (ARMS2) gene on the central visual field defects in retinitis pigmentosa (RP).


METHODS
The visual field was evaluated using the 10-2 Swedish Interactive Threshold Algorithm Fast Program and mean deviation (MD) slope, and regression coefficients of average sensitivity of the central 4 points (Cent4) were compared between each genetic subgroup.


RESULTS
The MD slope (right/left) was as follows: GG, -1.37 ± 2.18/ -0.89 ± 1.15; GT, -0.56 ± 1.40/-0.77 ± 1.04; TT, -0.75 ± 0.64/ -0.38 ± 0.92 dB/year. The Cent4 was as follows: GG, -1.34 ± 2.37/-1.60 ± 3.21; GT, -1.15 ± 2.08/1.07 ± 1.80; TT, -1.20 ± 0.91/-0.65 ± 1.37 dB/year. No significant differences in the degree of progression were observed when comparing groups.


CONCLUSIONS
These data suggest that polymorphisms of the ARMS2 do not modify the progression of the central field of vision in RP patients.
Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Hidetaka
H
Masahara
Mitsuru
M
Nakazawa
Eiji
E
Kawamura
Shuichiro
S
Eguchi
D002675:Child, Preschool; D004596:Electroretinography; D005260:Female; D056726:Genetic Association Studies; D060005:Genotyping Techniques; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012174:Retinitis Pigmentosa / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D014786:Vision Disorders / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*
C514392:ARMS2 protein, human; D011506:Proteins