Drug-eluting scaffolds for bone and cartilage regeneration.
The advances in strategies for bone and cartilage regeneration have been centered on a concept that describes the close relationship between osteogenic cells, osteoconductive scaffolds, delivery growth factors and the mechanical environment. The dynamic nature of the tissue repair process involves intricate mimicry of signals expressed in the biological system in response to an injury. Recently, synergistic strategies involving hybrid delivery systems that provide sequential dual delivery of biomolecules and relevant topological cues received great attention. Future advances in tissue regeneration will therefore depend on multidisciplinary strategies that encompass the crux of tissue repair aimed at constructing the ideal functional regenerative scaffold. Here, functional scaffolds delivering therapeutics are reviewed in terms of their controlled release and healing capabilities.
Nanyang Technological University, School of Materials Science & Engineering, Division of Materials Technology, N4.1-01-04a, 50 Nanyang Avenue, Singapore 639798, Singapore.
Charlotte L
CL
Huang
Nanyang Technological University, School of Materials Science & Engineering, Division of Materials Technology, N4.1-01-04a, 50 Nanyang Avenue, Singapore 639798, Singapore.
Wei Li
WL
Lee
Nanyang Technological University, School of Materials Science & Engineering, Division of Materials Technology, N4.1-01-04a, 50 Nanyang Avenue, Singapore 639798, Singapore. Electronic address: joachimloo@ntu.edu.sg.
Joachim S C
JS
Loo
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D002356:Cartilage / Q000187:drug effects / Q000502:physiology*; D004337:Drug Carriers / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D011108:Polymers / Q000008:administration & dosage; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D054457:Tissue Scaffolds / Q000639:trends
D004337:Drug Carriers; D011108:Polymers