Metastasis of lung adenosquamous carcinoma to meningioma: case report with literature review.
The occurrence of metastasis of a systemic neoplasm to an intracranial tumor is a rare phenomenon. Meningiomas have been reported as the most common intracranial tumor to harbor a systemic metastasis, with breast and lung carcinomas being the most common sites of origination. Here, we report a case of an adenocarcinoma metastasis of an adenosquamous lung carcinoma found within a meningioma, resulting in the patient's first clinical manifestations. We also review the literature for other cases of adenocarcinoma metastatic to a meningioma and suggest mechanisms that make meningiomas likely to harbor systemic metastases including increased vascularity, slow growth rate, increased hyaline content and expression of cell-cell adhesion molecules.
Department of Radiation Biology, Memorial Sloan Kettering Cancer Center New York, NY.
Ryan
R
Glass
Supriya R
SR
Hukku
Bruce
B
Gershenhorn
Juan
J
Alzate
Bradford
B
Tan
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D000077192:Adenocarcinoma of Lung; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged
D014408:Biomarkers, Tumor
Tumor-to-tumor; adenosquamous carcinoma; meningioma