Novel and versatile synthesis of disubstituted 1,2-dihydro-1,2,4-triazol-3-ones.
A novel method for the synthesis of a wide range of 1,5-disubstituted 1,2-dihydro-1,2,4-triazol-3-ones is described. The key step involves a reaction between a dilithiated BOC-hydrazine and a N-alkoxycarbonylcarboximidothioate. A broad range of aryl and alkyl functional groups are tolerated, providing a versatile route for the synthesis of triazolones.
Oncology Innovative Medicines, AstraZeneca , Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K.
Mark A
MA
Graham
Paul A
PA
Bethel
Jonathan
J
Burgess
Gary
G
Fairley
Steve C
SC
Glossop
Ryan D R
RD
Greenwood
Clifford D
CD
Jones
Scott
S
Lovell
Steve
S
Swallow
D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D009942:Organometallic Compounds; D014230:Triazoles; D008094:Lithium