Oral fibroma with HPV-associated epithelial dysplasia: even in fibromas you should look for the unexpected.
Fibromas are the most common soft tissue lesions of the oral cavity and are generally attributed to trauma. Koilocytic dysplasia refers to human papillomavirus (HPV)-related epithelial cytopathic effect. Koilocytic dysplasia is considered neoplastic. Herein, we report a case of oral fibroma with HPV-induced dysplastic changes of the surface epithelium confirmed by immunohistochemical stains for p16 and p53 as well as HPV in situ hybridization.
1University of Minnesota, Minneapolis, MN, USA.
Prokopios P
PP
Argyris
Ioannis G
IG
Koutlas
D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000473:pathology / Q000821:virology; D005350:Fibroma / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D014412:Tumor Virus Infections
D014408:Biomarkers, Tumor
HPV; fibroma; koilocytic dysplasia; p16; p53