Drug-eluting versus bare-metal coronary stents: where are we now?
Drug-eluting stents have dramatically reduced the risk of restenosis, but concerns of an increased risk of stent thrombosis have provided uncertainty about their use. Recent studies have continued to show improved procedural and clinical outcomes with drug-eluting stents both in the setting of acute coronary syndromes and stable coronary artery disease. Newer generation drug-eluting stents (especially everolimus-eluting stents) have been shown to be not only efficacious but also safe with reduced risk of stent thrombosis when compared with bare-metal stents, potentially changing the benchmark for stent safety from bare-metal stents to everolimus-eluting stents. While much progress is being made in the development of bioabsorbable polymer stents, nonpolymer stents and bioabsorbable stent technology, it remains to be seen whether these stents will have superior safety and efficacy outcomes compared with the already much improved rates of revascularization and stent thrombosis seen with newer generation stents (everolimus-eluting stents and resolute zotarolimus-eluting stents).
Cardiovascular Clinical Research Center, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA.
Nicholas S
NS
Amoroso
Sripal
S
Bangalore
D020341:Absorbable Implants; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D023903:Coronary Restenosis / Q000191:economics / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D004338:Drug Combinations; D054855:Drug-Eluting Stents / Q000191:economics / Q000639:trends; D005544:Forecasting; D006083:Graft Occlusion, Vascular / Q000191:economics / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000191:economics / Q000628:therapy; D009204:Myocardial Revascularization / Q000191:economics / Q000379:methods; D062645:Percutaneous Coronary Intervention / Q000191:economics / Q000379:methods; D010975:Platelet Aggregation Inhibitors / Q000191:economics / Q000627:therapeutic use; D011108:Polymers / Q000627:therapeutic use; D015607:Stents / Q000191:economics / Q000639:trends*; D013927:Thrombosis / Q000191:economics / Q000209:etiology
D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D011108:Polymers