Drug targets for lymphatic filariasis: a bioinformatics approach.
This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics is a rapidly growing field of biological study, and it has an increasingly significant role in various fields of biology. We have reviewed its leading involvement in the filarial research using different approaches of bioinformatics and have summarized available existing drugs and their targets to re-examine and to keep away from the resisting conditions. Moreover, some of the novel drug targets have been assembled for further study to design fresh and better pharmacological therapeutics. Various bioinformatics-based web resources, and databases have been discussed, which may enrich the filarial research.
Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India.
Om Prakash
OP
Sharma
Yellamandaya
Y
Vadlamudi
Arun Gupta
AG
Kota
Vikrant Kumar
VK
Sinha
Muthuvel Suresh
MS
Kumar
D000818:Animals; D017178:Brugia malayi / Q000187:drug effects / Q000235:genetics*; D019295:Computational Biology; D055808:Drug Discovery; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000469:parasitology*; D005369:Filaricides / Q000494:pharmacology*; D049751:Genome, Helminth / Q000235:genetics*; D015801:Helminth Proteins / Q000187:drug effects / Q000235:genetics; D006801:Humans; D014958:Wuchereria bancrofti / Q000187:drug effects / Q000235:genetics*
D005369:Filaricides; D015801:Helminth Proteins