The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions.
BACKGROUND
Frequent outbreak of herpes labialis can affect quality of life by prodromes like burning, itching, and swelling. Topical applied preparations aim to shorten the duration of symptoms, inhibit the virus replication and/or accelerate the healing process. Local concentrated heat (LCH) can reduce burning, itching, or swelling of the skin by influence of mechano-heat sensitive afferent neurons.


METHODS
To examine the effectiveness of two different topical applications (LCH versus topical acyclovir [TACV]) under real life conditions, we conducted a prospective, observational, reference-controlled cohort pilot study with 103 patients. Occurrence of prodromal burning, itching, swelling, and quality of life were assessed.


RESULTS
The LCH observation group (OG) showed a significantly faster improvement in all symptoms after 1-day of application than the TACV OG. The burden and duration of disease was lower and shorter in the LCH OG than in the TACV OG.


CONCLUSIONS
The prodromal symptoms in recurrent herpes labialis were attenuated more effectively by LCH than by TACV.
Department of Dermatology and Venereology, Martin Luther University of Halle-Wittenberg, Halle, Germany.
Johannes
J
Wohlrab
Franziska
F
Voß
Christian
C
Müller
Lars C
LC
Brenn
acyclovir; herpes labialis; local concentrated heat