Nanopore-based sequencing and detection of nucleic acids.
Nanopore-based techniques, which mimic the functions of natural ion channels, have attracted increasing attention as unique methods for single-molecule detection. The technology allows the real-time, selective, high-throughput analysis of nucleic acids through both biological and solid-state nanopores. In this Minireview, the background and latest progress in nanopore-based sequencing and detection of nucleic acids are summarized, and light is shed on a novel platform for nanopore-based detection.
Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (P. R. China).
Yi-Lun
YL
Ying
Junji
J
Zhang
Rui
R
Gao
Yi-Tao
YT
Long
D001483:Base Sequence; D008958:Models, Molecular; D058608:Nanopores; D036103:Nanotechnology; D009696:Nucleic Acids / Q000032:analysis*
D009696:Nucleic Acids
DNA sequencing; ion channels; membrane proteins; nanopores; single-molecule studies