Inherited disorders of platelet function.
Inherited platelet function disorders are of variable severity and unknown frequency and may be difficult to diagnose. Nevertheless, they are increasingly recognized as an important cause of bleeding in pediatrics, particularly in adolescent girls with menorrhagia, where they may be more common than von Willebrand disease. This article reviews the presentation of these disorders, summarizes the most common types of platelet function disorders, discusses the challenges in diagnostic testing, and details treatment and supportive care options.
Division of Hematology/Oncology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA; Cancer and Blood Disorders Center, Seattle Children's Hospital MS MB.8.501, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA. Electronic address: dana.matthews@seattlechildrens.org.
Dana C
DC
Matthews
D000293:Adolescent; D001791:Blood Platelet Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D001792:Blood Platelets / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010979:Platelet Function Tests
Bruising; Epistaxis; Menorrhagia; Platelet aggregation; Platelets