Distal connectivity causes summation and division across mouse visual cortex.
Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual cortex (V1). This local activity had two effects at distal V1 locations: summation and division. The balance between the two depended on visual contrast, and a normalization model precisely captured these effects.
UCL Institute of Ophthalmology, University College London, London, UK.
Tatsuo K
0000000348807682
TK
Sato
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Michael
M
Häusser
UCL Institute of Ophthalmology, University College London, London, UK.
Matteo
M
Carandini
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000075402:Channelrhodopsins; D004558:Electric Stimulation; D018274:Electroporation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008164:Luminescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D062308:Optogenetics; D010775:Photic Stimulation; D011247:Pregnancy; D018709:Statistics, Nonparametric; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology; D014793:Visual Cortex / Q000166:cytology*; D014795:Visual Pathways / Q000187:drug effects / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology* / Q000528:radiation effects; D000097573:Red Fluorescent Protein
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000075402:Channelrhodopsins; D018691:Excitatory Amino Acid Antagonists; D008164:Luminescent Proteins; D014633:Valine; D000097573:Red Fluorescent Protein; C056639:2-amino-5-phosphopentanoic acid