Spectroscopy analysis of chitosan-glibenclamide hydrogels.
The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both chitosan using theoretical calculations like Gibbs free energy, electrostatic potential, FTIR and NMR spectroscopy. Fourier transform infrared (FT-IR) spectroscopy reveals information about the molecular interactions of chemical components and is useful to characterization of hydrogel. Nucleophilic and electrophilic regions were calculated using the electrostatic potential.
División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Aguascalientes, Aguascalientes, Mexico.
Nancy-Liliana
NL
Delgadillo-Armendariz
División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Aguascalientes, Aguascalientes, Mexico. Electronic address: norma_rangel79@prodigy.net.mx.
Norma-Aurea
NA
Rangel-Vázquez
División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Aguascalientes, Aguascalientes, Mexico.
Alejandra-Ibeth
AI
García-Castañón
D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D005905:Glyburide / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013816:Thermodynamics
D003432:Cross-Linking Reagents; D020100:Hydrogels; D007004:Hypoglycemic Agents; D048271:Chitosan; D005905:Glyburide
Chitosan; FTIR; Glibenclamide; NMR