AKAP signaling complexes: pointing towards the next generation of therapeutic targets?
A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.
Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Jessica L
JL
Esseltine
John D
JD
Scott
D054758:A Kinase Anchor Proteins / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D013379:Substrate Specificity
D054758:A Kinase Anchor Proteins
AKAP; Ca(2+); disease; interfering peptide; protein kinase; protein phosphatase; signal transduction