Mouse model of post-arthroplasty Staphylococcus epidermidis joint infection.
Animal models are invaluable tools for translational research, allowing investigators to recapitulate observed clinical scenarios within the laboratory that share attributes with human disease. Here, we describe a mouse model of post-arthroplasty Staphylococcus epidermidis joint infection which mimics human disease and may be utilized to explore the complex series of events during staphylococcal implant-associated infections by identifying key immunological, bacterial, and/or therapeutic mechanisms relevant to these persistent infections.
Department of Pathology and Microbiology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, NE, USA.
Tyler D
TD
Scherr
Kevin E
KE
Lindgren
Carolyn R
CR
Schaeffer
Mark L
ML
Hanke
Curtis W
CW
Hartman
Tammy
T
Kielian
D000818:Animals; D001178:Arthroplasty; D018441:Biofilms; D004195:Disease Models, Animal; D006801:Humans; D007719:Knee Joint / Q000382:microbiology / Q000601:surgery; D007720:Knee Prosthesis / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000502:physiology*