Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome.
It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the heart. By the use of histology, laser capture microdissection and transcription analysis of tyrosinase genes, we here show that this melanisation is linked to de novo melanogenesis by melanomacrophages, suggesting an active part in the inflammatory reaction. No general systemic activation of the extracutaneous pigmentary system in response to viral infections with affinity to the heart was observed.
Hilde A S
HA
Fagerland
Lars
L
Austbø
Camilla
C
Fritsvold
Marta
M
Alarcon
Espen
E
Rimstad
Knut
K
Falk
Torunn
T
Taksdal
Section of Anatomy and Pathology, Department of Basic Science and Aquatic Medicine, Norwegian School of Veterinary Science, 0033 Oslo, Norway. erling.o.koppang@nvh.no.
Erling O
EO
Koppang
D000818:Animals; D005393:Fish Diseases / Q000473:pathology* / Q000503:physiopathology / Q000821:virology; D029941:Fish Proteins / Q000235:genetics / Q000378:metabolism; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism; D061346:Laser Capture Microdissection / Q000662:veterinary; D008543:Melanins / Q000378:metabolism*; D014442:Monophenol Monooxygenase / Q000235:genetics / Q000378:metabolism; D009205:Myocarditis / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary* / Q000821:virology; D009206:Myocardium / Q000276:immunology / Q000473:pathology*; D009664:Norway; D012327:RNA Virus Infections / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D020317:Salmo salar; D019196:Totiviridae / Q000502:physiology*
D029941:Fish Proteins; D008543:Melanins; D014442:Monophenol Monooxygenase; D019746:Intramolecular Oxidoreductases; C042501:dopachrome isomerase