Cognitive deficits in geriatric depression: clinical correlates and implications for current and future treatment.
The purpose of this article is to identify the cognitive deficits commonly associated with geriatric depression and describe their clinical significance. The complex relationship between geriatric depression and dementia is summarized and possible shared mechanisms discussed. Evidence regarding whether the cognitive deficits in depression may be mitigated with medication or with computerized cognitive remediation is presented.
Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA. Electronic address: ssm9006@med.cornell.edu.
Sarah Shizuko
SS
Morimoto
George S
GS
Alexopoulos
D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D015928:Cognitive Behavioral Therapy / Q000379:methods; D060825:Cognitive Dysfunction / Q000150:complications* / Q000473:pathology / Q000628:therapy; D003704:Dementia / Q000453:epidemiology; D003866:Depressive Disorder / Q000150:complications* / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D056344:Executive Function / Q000502:physiology*; D005852:Geriatric Psychiatry / Q000639:trends*; D006801:Humans; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms; D012307:Risk Factors; D016896:Treatment Outcome
D000928:Antidepressive Agents
Cognitive dysfunction; Cognitive remediation; Dementia; Executive function; Geriatric depression; Remission