Relation of uric acid and contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention in the ED.
OBJECTIVE
To investigate the predictive role of serum uric acid (SUA) levels measured in the emergency department (ED) to monitor contrast-induced nephropathy (CIN) and correlation with severity of nephropathy in patients undergoing primary percutaneous coronary intervention (PCI).


METHODS
The patients who were admitted to our ED and underwent primary PCI were enrolled retrospectively. Their baseline characteristics including SUA and creatinine levels in the ED and their creatinine levels 48 hours after PCI were noted. Nephropathy was graded as follows: grade 0, ΔCr ≤25% and ≤0.5 mg/dL; grade 1, ΔCr >25% but ≤0.5 mg/dL; and grade 2, ΔCr >0.5 mg/dL. A multiple logistic regression analysis was used to define the independent predictors of CIN.


RESULTS
Of a total of 744 patients, CIN was observed in 12.5% (n = 93). Serum uric acid levels were significantly higher in the CIN (+) group compared with the CIN (-) group (6.09 ± 2.01 mg/dL vs 4.89 ± 1.32 mg/dL, respectively; P < .001). Patients with grade 0 CIN had significantly lower SUA levels than did those with grades 1 and 2 (4.89 ± 1.32 mg/dL vs 5.88 ± 1.99 and 6.41 ± 2.02 mg/dL, respectively; P < .001), but there was no significant difference between grade 1 and grade 2 CIN cases in terms of SUA levels (5.88 ± 1.99 mg/dL vs 6.41 ± 2.02 mg/dL, P = .10). The cutoff value for SUA was 5.05 mg/dL for the prediction of CIN (area under the curve, 0.685; P < .001; sensitivity, 66%; specificity, 60%) in the population.


CONCLUSIONS
The SUA level is a simple independent early predictor of CIN in patients who underwent primary PCI, and early detection may help prevent the progression of CIN.
Department of Emergency Medicine, Atatürk University Medical Faculty, Erzurum, Turkey. Electronic address: muratsaritemur@gmail.com.
Murat
M
Saritemur
Department of Internal Medicine, Atatürk University Medical Faculty, Erzurum, Turkey.
Mehmet
M
Turkeli
Department of Cardiology, Atatürk University Medical Faculty, Erzurum, Turkey.
Kamuran
K
Kalkan
Department of Cardiology, Atatürk University Medical Faculty, Erzurum, Turkey.
İbrahim Halil
İH
Tanboga
Department of Cardiology, Atatürk University Medical Faculty, Erzurum, Turkey.
Enbiya
E
Aksakal
D000367:Age Factors; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
D003287:Contrast Media; D014527:Uric Acid; D003404:Creatinine