Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris.
Coronary heart disease (CHD) is the leading cause of mortality worldwide. The Chinese medicinal formula Guanxin II has been shown to have a favorable effect in the attenuation of angina. The aim of this study was to compare the pharmacokinetics of ferulic acid (FA), which is a vasorelaxant compound present in Guanxin II, in healthy volunteers and patients with angina pectoris following the administration of Guanxin II.Ex vivoexperiments were performed in order to investigate the vasorelaxant effect of FA on the human internal mammary artery (IMA) to provide evidence that it is a bioactive component of Guanxin II. Following the oral administration of Guanxin II, the FA levels in the serum were quantified by a simple and rapid high-performance liquid chromatography (HPLC) method. Treatment with FA (10-8-10-3M) caused a concentration-dependent relaxation of endothelial IMA rings following precontraction with KCl. Statistically significant differences were identified between the pharmaco-kinetic parameters Cmax, t1/2α, t1/2β and t1/2Ka of the healthy volunteers and the patients with angina pectoris following the oral administration of Guanxin II. FA is a bioactive compound absorbed from Guanxin II that attenuates angina pectoris, a condition that may modify the pharmacokinetics of FA. Not only do the pharmacokinetic parameters direct the clinical use of Guanxin II, but they may also be useful for exploring the pathology of angina pectoris.
Laboratory of Ethnopharmacology, Department of Integrated Chinese and Western Medicine, The National Key Clinical Specialist Vocational School, Xiangya Hospital, Central South University, Changsha, Hunan 410008; ; TCM Pharmacogenetics Laboratory, Central South University, Changsha, Hunan 410008;
Yun-Hui
YH
Li
Xi
X
Huang
Yang
Y
Wang
Rong
R
Fan
Hong-Min
HM
Zhang
Ping
P
Ren
Yao
Y
Chen
Hong-Hao
HH
Zhou
Zhao-Qian
ZQ
Liu
Yi-Zeng
YZ
Liang
Hong-Mei
HM
Lu
Guanxin II; absorbed bioactive compound; angina pectoris; ferulic acid; pharmacokinetics; vasorelaxant effect