TLR5 stops commensals in their tracks.
IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
Meghan A
MA
Koch
Gregory M
GM
Barton
D000818:Animals; D005408:Flagellin / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D018928:Immunity, Mucosal; D008124:Locomotion; D064307:Microbiota / Q000276:immunology*
D005408:Flagellin