Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity.
A soluble (pro)renin receptor (sPRR) circulates in plasma and is able to bind renin and prorenin. It is not known whether plasma sPRR concentrations vary with the activity of the renin-angiotensin system. We measured plasma sPRR, renin, prorenin, and aldosterone concentrations in 121 white and 9 black healthy subjects, 40 patients with diabetes mellitus, 41 hypertensive patients with or without renin-angiotensin system blockers, 9 patients with primary aldosteronism, and 10 patients with Gitelman syndrome. Median physiological plasma sPRR concentration was 23.5 ng/mL (interquartile range, 20.9-26.5) under usual uncontrolled sodium diet. sPRR concentration in healthy subjects, unlike renin and prorenin, did not display circadian variation or dependence on age, sex, posture, or hormonal status. sPRR concentrations were ≈25% lower in black than in white subjects, whereas renin concentrations were ≈40% lower. Patients with diabetes mellitus (average renin-high prorenin levels) and with hypertension only (average renin-average prorenin levels) had sPRR concentrations similar to healthy subjects. Renin-angiotensin system blockade was associated with increase of sPRR concentration by ≈12%. sPRR in patients with primary aldosteronism (low renin-low prorenin) and Gitelman syndrome (high renin-high prorenin) were similar and ≈10% higher than in healthy subjects. There was no correlation between sPRR and renin or prorenin. In conclusion, our results show that plasma sPRR concentrations are dependent on ethnicity and independent of renin, prorenin, and aldosterone concentrations in healthy subjects and in patients with contrasted degrees of renin-angiotensin system activity.
Centre for Interdisciplinary Research in Biology, UMR INSERM U1050/CNRS 7241, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05. genevieve.nguyen@college-de-france.fr.
Geneviève
G
Nguyen
Anne
A
Blanchard
Emmanuel
E
Curis
Damien
D
Bergerot
Yann
Y
Chambon
Takuo
T
Hirose
Aurore
A
Caumont-Prim
Sylvie Brailly
SB
Tabard
Stéphanie
S
Baron
Michael
M
Frank
Kazuhito
K
Totsune
Michel
M
Azizi
D000293:Adolescent; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D044383:Black People / Q000706:statistics & numerical data; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology; D003928:Diabetic Nephropathies / Q000097:blood / Q000208:ethnology*; D005260:Female; D053579:Gitelman Syndrome / Q000097:blood / Q000208:ethnology; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000208:ethnology; D006977:Hypertension, Renal / Q000097:blood / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011956:Receptors, Cell Surface / Q000097:blood*; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000502:physiology; D012995:Solubility; D025262:Vacuolar Proton-Translocating ATPases / Q000097:blood*; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult; D000093342:Prorenin Receptor
D000450:Aldosterone; D011956:Receptors, Cell Surface; D012083:Renin; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor
diabetes mellitus; ethnology; hyperaldosteronism; hypertension, essential