Ki67 and TP53 expressions predict recurrence of non-muscle-invasive bladder cancer.
Tumor markers Ki67, TP53, and TP63 are common labels in the diagnosis of bladder cancer (BCa) around the world. The combination of those biomarkers may have advantages in predicting BCa prognosis and non-muscle-invasive bladder cancer (NMIBC) postoperative recurrence. We investigated the immunohistochemical profiles of 313 bladder cancer samples classified under the WHO/ISUP (2004) grading scale and the UICC-TNM (2002) classification. Then we investigated their predictive value in the tumor recurrence of 270 NMIBC patients after TURBT. Expression of Ki67 correlates with grade, stage, tumor size, and tumor numbers. Semiquantitative evaluation of TP53 correlates with grade and invasive conditions. The positive expression rate of TP63 correlated with tumor grade and stage. The combined effect of TP53 and Ki67 revealed a predictive value in NMIBC recurrence. However, the positive TP63 expression did not show any protective effect in NMIBC recurrence. The expression of TP53 and Ki67 could be used to predict the risk of NMIBC recurrence postoperatively.
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Lujia
L
Wang
Chenchen
C
Feng
Guanxiong
G
Ding
Qiang
Q
Ding
Zhongwen
Z
Zhou
Haowen
H
Jiang
Zhong
Z
Wu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000473:pathology*; D009367:Neoplasm Staging; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology*
C081876:CKAP4 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53