Continuous infusion of propofol or intermittent bolus of tiletamine-zolazepam in feline night monkeys (Aotus infulatus).
BACKGROUND
Although commonly used, dissociative anesthesia results in unsatisfactory and long recovery periods. The intravenous anesthetic propofol seems to be the most advantageous solution. The objectives of this study were to investigate the required infusion rate of propofol to maintain surgical anesthesia and to compare it to tiletamine-zolazepam in Aotus infulatus.


METHODS
Eight healthy feline night monkeys were anesthetized with propofol (PRO) or tiletamine-zolazepam (TZ) during 60 minutes. Cardiopulmonary parameters, arterial blood gases and lactate and quality and times to recovery were determined.


RESULTS
Mean infusion rate of propofol was 0.53 ± 0.10 mg/kg/minute. Cardiopulmonary effects did not show marked differences between groups. Times for hanging, ventral recumbency, and normal ambulation were lower in PRO. Establishment of desirable anesthetic depth was easier, recovery quality was superior, and lactate levels were lower in PRO.


CONCLUSIONS
Compared with tiletamine-zolazepam, minor post-anesthetic adverse events should be expected with propofol anesthesia, as well as faster and better anesthetic recovery.
Veterinary Anesthesia and Analgesia Laboratory, Department of Veterinary Medicine, Federal University of Paraná, Curitiba, Brazil.
Rafaela
R
Galante
José A P C
JA
Muniz
Paulo H G
PH
Castro
Dorli S
DS
Amora
Vanessa N
VN
Gris
Elizabeth R
ER
Carvalho
Ricardo G D O C
RG
Vilani
D000758:Anesthesia / Q000379:methods* / Q000662:veterinary; D000762:Anesthesia Recovery Period; D000778:Anesthetics, Dissociative / Q000008:administration & dosage*; D000818:Animals; D016645:Aotidae / Q000502:physiology*; D001772:Blood Cell Count / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D004338:Drug Combinations; D005260:Female; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D013992:Tiletamine / Q000008:administration & dosage*; D015041:Zolazepam / Q000008:administration & dosage*
D000778:Anesthetics, Dissociative; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam; D015742:Propofol
anesthesia; lactate; primate; recovery; total intravenous anesthesia