Protease-mediated ectodomain shedding.
Ectodomain shedding is the proteolytic cleavage of cell surface proteins resulting in the loss of the extracellular domains. This mechanism is important in a variety of normal and pathological processes, including growth factor signalling, cell adhesion, inflammation and cell survival. Elevated protease activity in the lungs is a key pathological mechanism in emphysema which could enhance ectodomain shedding in lung cells. Here, the major steps and consequences of ectodomain shedding are reviewed.
Peter
P
Clark
D051722:ADAM Proteins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000502:physiology*; D059748:Proteolysis; D011656:Pulmonary Emphysema / Q000201:enzymology* / Q000503:physiopathology*
D008565:Membrane Proteins; D010447:Peptide Hydrolases; D051722:ADAM Proteins
ADAMs; emphysema; matrix metalloproteinase; secretase; sheddase