A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye.
The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover and three different fluorescent formulations, which were made of photopolymeized tri(ethyleneglycol)dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each fluorescent is controlled by varying the PEGDM/TEGDM ratio in its formulation and the cover. The release kinetics appeared to be related to the swelling ratio of the PEGDM/TEGDM polymers. When the devices were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks' implantation and distributed locally around the implantation site. Our polymeric system, which can administer multiple compounds with distinct kinetics, provides prolonged action and less invasive transscleral administration, and is expected to provide new tools for the treatment of posterior eye diseases with new therapeutic modalities.
Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Nobuhiro
N
Nagai
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan.
Hirokazu
H
Kaji
Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Hideyuki
H
Onami
Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Yumi
Y
Ishikawa
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan.
Matsuhiko
M
Nishizawa
Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Noriko
N
Osumi
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Toru
T
Nakazawa
Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: toshi@oph.med.tohoku.ac.jp.
Toshiaki
T
Abe
D000818:Animals; D004058:Diffusion; D016503:Drug Delivery Systems / Q000295:instrumentation*; D019793:Fluorescein / Q000378:metabolism; D007211:Indoles / Q000378:metabolism; D008689:Methacrylates / Q000737:chemistry*; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D057972:Posterior Eye Segment / Q000378:metabolism*; D019919:Prosthesis Implantation; D051381:Rats; D012160:Retina / Q000378:metabolism; D012235:Rhodamines / Q000378:metabolism; D012590:Sclera / Q000378:metabolism*
D007211:Indoles; D008689:Methacrylates; D011109:Polymethacrylic Acids; D012235:Rhodamines; C421283:poly(ethylene glycol)-dimethacrylate; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; C007293:DAPI; D019793:Fluorescein
Multi-drug delivery; Poly(ethyleneglycol) dimethacrylate; Retina; Transscleral delivery