Voice-related modulation of mechanosensory detection thresholds in the human larynx.
Rapidly adapting mechanoreceptors within the laryngeal mucosa provide the central nervous system with perceptual and proprioceptive afference for a variety of essential yet diverse human functions including voice sound production and airway protection. It is unknown why mechanosensory information that yields a defensive response when an individual breathes may go largely unnoticed when the individual voices. Therefore, a central question is whether there is voice-related modulation of laryngeal mechanosensory detection. Such modulation would be consistent with current models of afferent laryngeal control, and may be important to maintain fluent voice in the presence of potentially distracting sensory input. Therefore, we employed endoscopic assessment of laryngeal mechanosensory detection thresholds in ten healthy adults during tidal breathing and a voice task. We tested the hypothesis that laryngeal mechanosensory detection thresholds would be higher during the voice task. We found that thresholds were significantly higher for all participants during the voice task and that these changes were significantly more modest in women. Our findings suggest that the laryngeal sensorium may modulate mechanosensory afference to attenuate the potentially distracting influence of sensory input during voice. The finding that women maintain a greater sensitivity during the voice task than men (lower thresholds) may have important implications for the higher prevalence of sensorimotor voice disturbances in women. Our results are consistent with the presence of mechanosensory modulation in other motor systems and with observed sensory differences between women and men. Such modulation has important implications for understanding the underlying neural mechanisms of laryngeal control and how these mechanisms may operate in individuals with laryngeal disturbances.
Division of Otolaryngology, Department of Surgery, Room K4/769 Clinical Sciences Center, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, USA, hammer@surgery.wisc.edu.
Michael J
MJ
Hammer
Mallory A
MA
Krueger
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007821:Laryngeal Muscles / Q000502:physiology*; D007830:Larynx / Q000502:physiology*; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D012119:Respiration; D012684:Sensory Thresholds / Q000502:physiology*; D012737:Sex Factors; D013060:Speech / Q000502:physiology; D014831:Voice / Q000502:physiology*; D055815:Young Adult