Vesicular gold assemblies based on host-guest inclusion and its controllable release of doxorubicin.
We have developed a kind of gold nanoparticle (AuNP) in which polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are attached on the surface of a gold nanocrystal through the host-guest inclusion between adamantane groups (ADA) and β-cyclodextrin (β-CD). The resulting AuNPs become amphiphilic in water above body temperature and self-assemble into vesicles. It is found that these vesicles can load doxorubicin (Dox) effectively. With a decrease in temperature, the PNIPAM shifted from hydrophobic to hydrophilic, causing Au vesicles to disassemble into stable small AuNPs, triggering the release of Dox. These hybrid vesicles, combining polymer functionality with the intriguing properties of AuNPs, can first release free Dox and AuNP/Dox at a site of a tumor through the application of either simple ice packs or deeply penetrating cryoprobes, then the AuNP/Dox can be taken in by tumor cells and destroy them like miniature munitions. Furthermore, these vesicles showed other therapeutic possibilities due to the presence of gold. We believe that the development of such multi-functional vesicles will provide new and therapeutically useful means for medical applications.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
Wei
W
Ha
Yang
Y
Kang
Shu-Lin
SL
Peng
Li-Sheng
LS
Ding
Sheng
S
Zhang
Bang-Jing
BJ
Li
D000180:Acrylic Resins / Q000737:chemistry; D000218:Adamantane / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D050997:Nanomedicine; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers; D013499:Surface Properties; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry
D000180:Acrylic Resins; D011108:Polymers; D047392:beta-Cyclodextrins; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D006046:Gold; D004317:Doxorubicin; C031215:betadex; D000218:Adamantane