A new twist to the GATA switch.
In this issue of Blood, Takai et al provide some tantalizing clues on how expression of the GATA1 transcription factor, a master regulator of erythroid/megakaryocytic differentiation, is suppressed in the hematopoietic stem/progenitor cell (HSPC) compartment.
ERASMUS UNIVERSITY MEDICAL CENTER, ROTTERDAM.
Sjaak
S
Philipsen
D000818:Animals; D041905:Erythroid Cells / Q000378:metabolism*; D050982:GATA1 Transcription Factor / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*
D050982:GATA1 Transcription Factor; C494689:Gata1 protein, mouse