New synthetic antibiotics for the treatment of Enterococcus and Campylobacter infection.
Bacterial resistance to antibiotics, particularly to multiple drug resistant antibiotics, is becoming cause for significant concern. The only really viable course of action is to discover new antibiotics with novel mode of actions. This review focuses on antibiotic resistance mechanisms of Enterococcus and Campylobacter, and new antibacterial agents against Enterococcus and Campylobacter through de novo or semi- synthesis in the period from 2003 until mid- 2013.
Hai-Wei
HW
Xu
Shang-Shang
SS
Qin
New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, No. 100, KeXue DaDao, Zhengzhou 450001, China. liuhm@zzu.edu.cn.
Hong-Min
HM
Liu
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002169:Campylobacter Infections / Q000188:drug therapy; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D016983:Enterococcus / Q000187:drug effects*; D006801:Humans; D048628:Ketolides / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D010456:Peptides, Cyclic