Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: redox-neutral and traceless by N-N bond cleavage.
Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a Rh(III) -catalyzed directed CH activation step and a successive coupling with alkynes.
Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/index.html.
Dongbing
D
Zhao
Zhuangzhi
Z
Shi
Frank
F
Glorius
D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006834:Hydrazines / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
D006834:Hydrazines; D007211:Indoles; C029424:hydrazine; D002244:Carbon; D006859:Hydrogen; C030374:indole; D012238:Rhodium; D009584:Nitrogen
CH activation; heteroarenes; indoles; oxidizing directing groups; rhodium catalysis