Amide bond formation via C(sp3)-H bond functionalization and CO insertion.
An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Paul.Dyson@epfl.ch.
Huizhen
H
Liu
Gabor
G
Laurenczy
Ning
N
Yan
Paul J
PJ
Dyson
D000473:Alkanes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen; D007659:Ketones / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011789:Quantum Theory
D000473:Alkanes; D000577:Amides; D000814:Aniline Compounds; D007659:Ketones; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C023650:aniline