[A case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) with treatment-resistant status epilepticus that was effectively treated with lamotrigine].
A 16-year-old woman with MELAS developed fever and myoclonic epilepsy which improved with conventional anti-epileptic drugs. Since seizures recurred one month after successful treatment, the doses of phenobarbital, clonazepan, and valproate were increased. However, there was no improvement and status epilepticus continued. The addition of lamotrigine resulted in a decreased frequency and good control of seizures. This case is important, showing satisfactory results from the addition of lamotrigine for treatment-resistant status epilepticus.
Department of Neurology, Imakiire General Hospital.
Toru
T
Kai
Shuichiro
S
Masuda
Hiroyasu
H
Tokunaga
Shigeaki
S
Hayashi
Tatsui
T
Nagado
Yoshikazu
Y
Maruyama
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D017241:MELAS Syndrome / Q000150:complications*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000209:etiology; D014227:Triazines / Q000627:therapeutic use*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine