Soluble RAGE plasma levels in patients with coronary artery disease and peripheral artery disease.
The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. Clinical and laboratory parameters including the ankle brachial index (ABI) and sRAGE (enzyme-linked immunosorbent assay kit) were investigated in 544 patients with angiographically documented CAD and 328 control subjects. 213/554 CAD patients (39%) showed an ABI <0.9 associated with typical symptoms (group CAD + PAD), whereas 331 patients were free from PAD. The concentration of plasma sRAGE was significantly lower (P < 0.0001) in CAD population, with and without PAD, than in control subjects. Among CAD patients, those with PAD showed lower levels of sRAGE. The distribution of the three groups (CAD, CAD + PAD, and controls) according to sRAGE tertiles showed that lower levels were more frequent in patients with CAD and CAD + PAD, whereas higher levels were more frequently found in controls. CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE.
Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, Italy ; Department of Cardiology, "Istituti Clinici di Pavia e Vigevano" University Hospital, 27100 Pavia, Italy ; IRCCS San Donato Hospital, San Donato Milanese, 20097 Milan, Italy ; Department of Internal Medicine, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Colomba
C
Falcone
Sara
S
Bozzini
Luigina
L
Guasti
Angela
A
D'Angelo
Anna Clizia
AC
Capettini
Edoardo Maria
EM
Paganini
Rossana
R
Falcone
Roberto
R
Moia
Carmine
C
Gazzaruso
Gabriele
G
Pelissero
D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index; D012995:Solubility
D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic