Chemical composition and antimicrobial activity of the essential oil from the edible aromatic plant Aristolochia delavayi.
The essential oil obtained by hydrodistillation from the aerial parts of Aristolochia delavayi Franch. (Aristolochiaceae), a unique edible aromatic plant consumed by the Nakhi (Naxi) people in Yunnan, China, was investigated using GC/MS analysis. In total, 95 components, representing more than 95% of the oil composition, were identified, and the main constituents found were (E)-dec-2-enal (52.0%), (E)-dodec-2-enal (6.8%), dodecanal (3.35%), heptanal (2.88%), and decanal (2.63%). The essential oil showed strong inhibitory activity (96% reduction) of the production of bacterial volatile sulfide compounds (VSC) by Klebsiella pneumoniae, an effect that was comparable with that of the reference compound citral (91% reduction). Moreover, the antimicrobial activity of the essential oil and the isolated major compound against eight bacterial and six fungal strains were evaluated. The essential oil showed significant antibacterial activity against Providencia stuartii and Escherichia coli, with minimal inhibitory concentrations (MIC) ranging from 3.9 to 62.5 μg/ml. The oil also showed strong inhibitory activity against the fungal strains Trichophyton ajelloi, Trichophyton terrestre, Candida glabrata, Candida guilliermondii, and Cryptococcus neoformans, with MIC values ranging from 3.9 to 31.25 μg/ml, while (E)-dec-2-enal presented a lower antifungal activity than the essential oil.
School of Life Sciences, Yunnan University, Kunming 650091, P. R. China; State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China, (phone: +86-871-5223224; fax: +86-871-5216335).
Zhi-Jian
ZJ
Li
Guy S S
GS
Njateng
Wen-Jia
WJ
He
Hong-Xia
HX
Zhang
Jian-Long
JL
Gu
Shan-Na
SN
Chen
Zhi-Zhi
ZZ
Du
D000890:Anti-Infective Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D030022:Aristolochia / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D009822:Oils, Volatile / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D010945:Plants, Edible / Q000737:chemistry
D000890:Anti-Infective Agents; D009822:Oils, Volatile
(E)-Dec-2-enal; Antimicrobial activity; Aristolochia delavayi; Essential oils; Volatile sulfide compounds (VSC)