Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography.
While islet transplantation is considered a useful therapeutic option for severe diabetes mellitus (DM), the outcome of this treatment remains unsatisfactory. This is largely due to the damage and loss of islets in the early transplant stage. Thus, it is important to monitor the condition of the transplanted islets, so that a treatment can be selected to rescue the islets from damage if needed. Recently, numerous trials have been performed to investigate the efficacy of different imaging modalities for visualizing transplanted islets. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are the most commonly used imaging modalities for this purpose. Some groups, including ours, have also tried to visualize transplanted islets by ultrasonography (US). In this review article, we discuss the recent progress in islet imaging.
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Naoaki
N
Sakata
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Gumpei
G
Yoshimatsu
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Haruyuki
H
Tsuchiya
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Takeshi
T
Aoki
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Masamichi
M
Mizuma
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Fuyuhiko
F
Motoi
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan; Division of Integrated Surgery and Oncology; Tohoku University Graduate School of Medicine; Sendai, Japan.
Yu
Y
Katayose
Department of Biomedical Engineering; Graduate School of Biomedical Engineering; Tohoku University; Sendai, Japan.
Tetsuya
T
Kodama
Division of International Cooperation for Disaster Medicine; International Research Institute of Disaster Science; Tohoku University; Sendai, Japan.
Shinichi
S
Egawa
Division of Hepato-Biliary-Pancreatic Surgery; Department of Surgery; Tohoku University Graduate School of Medicine; Sendai, Japan.
Michiaki
M
Unno
D000818:Animals; D003920:Diabetes Mellitus / Q000601:surgery*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon; D014463:Ultrasonography
diabetes mellitus (DM); islet; islet transplantation; magnetic resonance imaging (MRI); positron emission tomography (PET); ultrasonography or ultrasound (US)