Diversin increases the proliferation and invasion ability of non-small-cell lung cancer cells via JNK pathway.
The expression and significance of Diversin in human tumors remains unclear. We found that Diversin was overexpressed in NSCLC, and exhibited direct correlation to poor differentiation, advanced TNM stage, lymph node metastasis and survival time. Overexpression of Diversin lead to a significant increase in proliferation and invasion of NSCLC cells, possibly through activation of JNK, cyclin B and MMP9, and the effects were blocked by JNK inhibitor. These results suggest Diversin is overexpressed in NSCLC and predict poor prognosis. Diversin may promote cell proliferation and invasion through JNK pathway.
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China; Department of Pathology, Fengtian Hospital Affiliated To Shenyang Medical College, Shenyang, China.
Lan
L
Luan
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Yue
Y
Zhao
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Zhonghai
Z
Xu
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Guiyang
G
Jiang
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Xiupeng
X
Zhang
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Chuifeng
C
Fan
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Di
D
Liu
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Huanyu
H
Zhao
Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, China.
Ke
K
Xu
Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, China.
Minghao
M
Wang
Department of Breast Surgery and Surgical Oncology, Research Unit of General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China.
Xinmiao
X
Yu
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address: wangeh@hotmail.com.
Enhua
E
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000172:deficiency / Q000235:genetics; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D060449:Wnt Signaling Pathway
C464902:ANKRD6 protein, human; D003598:Cytoskeletal Proteins
Diversin; JNK; Non-small-cell lung cancer; Wnt