Neural nAChRs PET imaging probes.
There have been a number of attempts to study PET radioligands for imaging nicotinic acetylcholine receptors (nAChRs) in the human brain, and the most successful tracers found are radioligands for imaging α4β2-nAChRs, which is the main cerebral nAChRs subtype. C-Nicotine and 2-[F]FA have been applied in many studies in humans. However, neither is entirely ideal and efforts have been made to develop radioligands with optimized imaging properties. Only a few reports have been published on radioligands for α7-nAChRs imaging, another important cerebral nAChRs subtype. This paper will review the development of PET radioligands for imaging cerebral nAChRs.
Department of Nuclear Medicine, the First Hospital of China Medical University, Shenyang, China.
Ye-Xiong
YX
Mo
Ya-Fu
YF
Yin
Ya-Ming
YM
Li
D004194:Disease; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy; D009420:Nervous System / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D011978:Receptors, Nicotinic / Q000378:metabolism*
D011978:Receptors, Nicotinic