Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function.
Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain).
Luis
L
González-Bulnes
Ignacio
I
Ibáñez
Luis M
LM
Bedoya
Manuela
M
Beltrán
Silvia
S
Catalán
José
J
Alcamí
Santos
S
Fustero
José
J
Gallego
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012313:RNA / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013730:Terphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000378:metabolism
D019380:Anti-HIV Agents; D013730:Terphenyl Compounds; D054321:rev Gene Products, Human Immunodeficiency Virus; D012313:RNA
HIV; RNA; drug design; small-molecule inhibitors; terphenyls