Induction of triterpene biosynthesis by elicitors in suspension cultures of Tabernaemontana species.
Treatment of suspension cultures of some Tabernaemontana species (Apocynaceae) with elicitors (e.g. cellulase, Candida albicans) result in a rapid de novo production of antimicrobial active triterpenes. The triterpenes are identified as ursene carboxylic acid derivatives. These triterpenes are not produced by an elicited cell suspension culture of Catharanthus roseus, another Apocynaceae.
Biotechnology Delft Leiden, Center for Bio-Pharmaceutical Sciences, Division of Pharmacognosy, Leiden University, P.O. Box 9502, NL-2300 RA, Leiden, The Netherlands.
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van der Heijden
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Verheij
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Schripsema
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Svendsen
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Verpoorte
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Harkes