Angiotensin (1-7) protects against stress-induced gastric lesions in rats.
Stress ulcers can develop with severe physiological stress, and have been proposed as being brain-driven events. New findings continue to suggest that stress ulcers can be more effectively managed through central manipulation rather than by simply altering local gastric factors. Angiotensin (1-7) (Ang (1-7)) is present as an endogenous constituent of the brain and stomach. The beneficial effects of Ang (1-7) have been confirmed in the vessels, brain, heart, kidney, liver and lungs, but not in the stomach. Given the accumulating evidence suggesting the anti-stress activities of Ang (1-7), its potential gastroprotective effect in the context of stress requires further investigation. In the present study, rat gastric mucosal lesions were induced by 2h of cold-restraint stress. We observed that these lesions were significantly attenuated after 1 week of intracerebroventricular treatment with Ang (1-7). This gastroprotective effect was associated with attenuated oxidative stress and suppressed acid secretion. Brain Ang (1-7) administration profoundly modified responses to stress, indicated by altered levels of several stress hormones, including Ang II, glucocorticoid, norepinephrine, serotonin, and dopamine, in blood or stress-related brain regions. These findings indicate that Ang (1-7) exerts anti-stress activities by restoring the gastric microenvironment and modulating the stress pathways. Ang (1-7) may be a promising agent for stress ulcer prophylaxis and therapy, administered through brain-permeable mimics or carriers.
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, PR China.
Donglin
D
Zhu
Department of Geriatrics, Huai'an First People's Hospital, Nanjing Medical University, P.O. Box 223300, No. 6 Beijing Road West, Huai'an, PR China.
Qiang
Q
Tong
Department of Neurology, Suzhou Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, P.O. Box 215009, No. 889 West Wuzhong Road, Suzhou, PR China.
Wei
W
Liu
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, PR China.
Minjie
M
Tian
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, PR China.
Wei
W
Xie
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, PR China.
Li
L
Ji
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, PR China. Electronic address: profshijp@163.com.
Jingping
J
Shi
D000803:Angiotensin I / Q000008:administration & dosage / Q000494:pharmacology*; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D003080:Cold Temperature / Q000009:adverse effects; D003345:Corticosterone / Q000097:blood; D017506:H(+)-K(+)-Exchanging ATPase / Q000235:genetics / Q000378:metabolism; D057967:Infusions, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000009:adverse effects; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological
D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; D017506:H(+)-K(+)-Exchanging ATPase; C118790:angiotensin I (1-7); D003345:Corticosterone; D009638:Norepinephrine
Angiotensin (1–7); Angiotensin (1–7) (PubChem CID: 123805); Angiotensin II (PubChem CID: 172198); Cold-restraint stress; Corticosterone (PubChem CID: 5753); Dopamine (PubChem CID: 681); Gastric lesions; Malondialdehyde (PubChem CID: 10964); Mas; Norepinephrine (PubChem CID: 439260); Oxidative stress; Serotonin (PubChem CID: 5202)