Intrinsic allosteric inhibition of signaling proteins by targeting rare interaction states detected by high-pressure NMR spectroscopy.
Institute of Biophysics and Physical Biochemistry, Centre of Magnetic Resonance in Chemistry and Biomedicine (CMRCB), University of Regensburg, Universitätsstrasse 31, 93047 Regensburg (Germany). Hans-Robert.Kalbitzer@Biologie.Uni-Regensburg.de.
Hans Robert
HR
Kalbitzer
Ina C
IC
Rosnizeck
Claudia E
CE
Munte
Sunilkumar Puthenpurackal
SP
Narayanan
Veronika
V
Kropf
Michael
M
Spoerner
D000494:Allosteric Regulation; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D015398:Signal Transduction
D011506:Proteins
Ras protein; allosteric inhibition; conformational states; drug design; high-pressure NMR spectroscopy