Surgical relocation of the papillary muscles in functional ischemic mitral regurgitation: what are the forces of the relocation stitches acting on the myocardium?
OBJECTIVE
In patients with chronic functional ischemic mitral regurgitation (FIMR), papillary muscle relocation has the potential to induce reverse left ventricular remodeling. However, in order to optimize function and durability, the forces imposed on the left ventricular myocardium by papillary muscle relocation should be assessed.


METHODS
Eight pigs with FIMR were subjected to down-sized ring annuloplasty in combination with relocation of the anterior (5 mm) and posterior (15 mm) papillary muscles towards the respective trigone. Papillary muscle relocation was obtained by a 2-0 expanded polytetrafluoroethylene stitch fixed to the trigone, exteriorized through the myocardium overlying the papillary muscle, and fixed to an epicardial disc. Tension in these stitches was measured at a systolic blood pressure > 80 mmHg using a custom-made sliding caliper with a strain gauge mounted in line. This allowed assessment of the cyclic change from minimal diastolic to maximum systolic papillary muscle relocation stitch tension.


RESULTS
Maximum cyclic change in the posterior papillary muscle (PPM) stitch tension was 1.1 N at 15 mm relocation. In comparison, the anterior papillary muscle (APM) tension was increased to a maximum of 1.4 N with only 5 mm relocation. Surprisingly, during each step of isolated PPM relocation, the APM stitch tension increased concomitantly, but in contrast APM relocation did not influence the magnitude of PPM stitch tension. There was no statistically significant difference between cyclic changes in APM and PPM stitch tension at any step of relocation.


CONCLUSIONS
Papillary muscle relocation using stitches attached between epicardial discs and respective trigones induced a cyclic change in papillary muscle relocation stitch tension of 1.1-1.4 N. These values were in the range of normal tension in the mitral valve apparatus, and equivalent to only 19-24% of the total papillary muscle forces. Therefore, this technique does not appear to induce a non-physiologically high cyclic load on the mitral valve complex.
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital-Skejby, Denmark. hjensen@dadlnet.dk
Henrik
H
Jensen
Morten O
MO
Jensen
Stefan
S
Vind-Kezunovic
Rikke
R
Vestergaard
Steffen
S
Ringgaard
Morten H
MH
Smerup
Jesper L
JL
Hønge
J Michael
JM
Hasenkam
Sten L
SL
Nielsen
D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods*; D004108:Dilatation, Pathologic / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D006334:Heart Function Tests; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D017202:Myocardial Ischemia / Q000150:complications*; D010210:Papillary Muscles / Q000601:surgery*; D012720:Severity of Illness Index; D013552:Swine; D016896:Treatment Outcome; D020257:Ventricular Remodeling