Air pollution effects on fetal and child development: a cohort comparison in China.
In Tongliang, China, a coal-fired power plant was the major pollution source until its shutdown in 2004. We enrolled two cohorts of nonsmoking women and their newborns before and after the shutdown to examine the relationship between prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) and fetal and child growth and development. PAHs were used to measure exposure to air pollution generated by the power plant. Using PAH-DNA adduct levels as biomarkers for the biologically effective dose of PAH exposure, we examined whether PAH-DNA adduct levels were associated with birth outcome, growth rate, and neurodevelopment. Head circumference was greater in children of the second cohort, compared with the first (p = 0.001), consistent with significantly reduced levels of cord blood PAH-DNA adducts in cohort II (p < 0.001) and reduced levels of ambient PAHs (p = 0.01).
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 W. 168th Street, New York, NY 10027, USA, Columbia Center for Children's Environmental Health. Electronic address: dt14@columbia.edu.
Deliang
D
Tang
Chongqing Medical University, Chongqing, China.
Ting Yu
TY
Li
Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA.
Judith C
JC
Chow
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 W. 168th Street, New York, NY 10027, USA, Columbia Center for Children's Environmental Health.
Sanasi U
SU
Kulkarni
Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA.
John G
JG
Watson
Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA; Hong Kong Premium Services and Research Laboratory, Chai Wan, China.
Steven Sai Hang
SS
Ho
Chongqing Medical University, Chongqing, China.
Zhang Y
ZY
Quan
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 W. 168th Street, New York, NY 10027, USA, Columbia Center for Children's Environmental Health.
L R
LR
Qu
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 W. 168th Street, New York, NY 10027, USA, Columbia Center for Children's Environmental Health.
Frederica
F
Perera
D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D000397:Air Pollution / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D002657:Child Development / Q000187:drug effects; D002681:China; D003031:Coal; D018736:DNA Adducts / Q000378:metabolism; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009420:Nervous System / Q000187:drug effects / Q000254:growth & development; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D011210:Power Plants; D055815:Young Adult
D000393:Air Pollutants; D015415:Biomarkers; D003031:Coal; D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; C095911:polycyclic aromatic hydrocarbons-DNA adduct
Birth outcomes; China; Neurodevelopment; PAH–DNA adducts; Polycyclic aromatic hydrocarbons