A sting in the tale of TH2 immunity.
Allergies are widely considered misguided Th2 cell responses. In this issue, Palm et al. (2013) and Marichal et al. (2013) show that mice mount anti-venom Th2 cell responses that share components of the "allergic" response but confer protection.
Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany.
Dario A
DA
Gutierrez
Hans-Reimer
HR
Rodewald
D000818:Animals; D001514:Bee Venoms / Q000201:enzymology* / Q000633:toxicity*; D005260:Female; D006967:Hypersensitivity / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology*; D019476:Insect Proteins / Q000276:immunology*; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008246:Lysophospholipids / Q000276:immunology*; D054467:Phospholipases A2 / Q000276:immunology*; D018123:Receptors, Interleukin / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D001514:Bee Venoms; C486189:Il1rl1 protein, mouse; D019476:Insect Proteins; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008246:Lysophospholipids; D018123:Receptors, Interleukin; D007073:Immunoglobulin E; D054467:Phospholipases A2