The Reactome pathway knowledgebase.
Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.
European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA, NYU School of Medicine, New York, NY 10016, USA, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.
David
D
Croft
Antonio Fabregat
AF
Mundo
Robin
R
Haw
Marija
M
Milacic
Joel
J
Weiser
Guanming
G
Wu
Michael
M
Caudy
Phani
P
Garapati
Marc
M
Gillespie
Maulik R
MR
Kamdar
Bijay
B
Jassal
Steven
S
Jupe
Lisa
L
Matthews
Bruce
B
May
Stanislav
S
Palatnik
Karen
K
Rothfels
Veronica
V
Shamovsky
Heeyeon
H
Song
Mark
M
Williams
Ewan
E
Birney
Henning
H
Hermjakob
Lincoln
L
Stein
Peter
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D'Eustachio
D030562:Databases, Protein; D004194:Disease; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D053858:Metabolic Networks and Pathways; D011506:Proteins / Q000378:metabolism*
D011506:Proteins