[Expression of microRNA-31 and its clinicopathologic significance in oral squamous cell carcinoma].
OBJECTIVE
To investigate the expression of microRNA-31 and its association with clinicopathologic features in oral squamous cell carcinoma (OSCC).


METHODS
The expression level of microRNA-31 in 62 cases of OSCC and matched non-tumor adjacent tissue specimens was examined using stem-loop real-time PCR. The relationship between the expression of microRNA-31 and its clinicopathologic features of OSCC was analyzed.


RESULTS
The expression of microRNA-31 was significantly higher in the tumor tissues than that in the adjacent tissues (P < 0.05).Up-regulated microRNA-31 expression was associated with the lymph node metastasis (P < 0.05) and cell differentiation (P < 0.05) in OSCC patients.No significant association was found between the expression of microRNA-31 and gender, age, lymph node metastasis, tumor size and location.Receiver operator characteristic curve (ROC) of microRNA-31 about cell differentiation resulted in a diagnostic sensitivity of 70.4% and specificity of 89.5%.


CONCLUSIONS
The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.
Department of Prosthodontics, The Affiliated Stomatological Hospital of Nanchang University, Nanchang 330006, China.
Shao-bo
SB
Ouyang
Jun
J
Wang
Zi-kun
ZK
Huang
Lan
L
Liao
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation; D055815:Young Adult
C534612:MIRN31 microRNA, human; D035683:MicroRNAs