BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation.
Although in the last few years γδ T lymphocytes have been the subject of growing interest as potential anticancer immunotherapeutics, how the proliferative and effector responses of these cells are regulated remains unclear. We have recently reported that the co-receptor B and T lymphocyte associated (BTLA) inhibits the proliferation of human Vγ9Vδ2 T cells, potentially underpinning a mechanism of immune escape by lymphoma cells.
Aix-Marseille Université; Marseille, France ; Institut National de la Santé et de la Recherche Médicale; Centre de Recherche en Cancérologie de Marseille; Marseille, France ; Institut Paoli Calmettes; IBiSA Cancer Immunomonitoring Platform; Marseille, France.
Julie
J
Gertner-Dardenne
Cyril
C
Fauriat
Daniel
D
Olive
BTLA; co-signaling; lymphoma; γδ T cells