Antimicrobial metabolites from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022.
A quinoline alkaloid 1 and five known compounds (2-6) were isolated from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022, and their structures were determined by spectroscopic studies as 4-oxo-1,4-dihydroquinoline-3-carboxamide (1), p-hydroxybenzoic acid (2), N-acetyl-anthranilic acid (3), indoly-3-carboxylic acid (4), cyclo(Trp-Gly) (5) and cyclo(Leu-Ala) (6). Compound 1 was isolated from natural resources for the first time. Compounds 1 and 3 showed antimicrobial activities against some plant pathogens.
a Key Laboratory of Microbial Diversity in Southwestern China of Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources, Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , P.R. China.
Shouzheng
S
Tian
Yabin
Y
Yang
Kai
K
Liu
Zijun
Z
Xiong
Lihua
L
Xu
Lixing
L
Zhao
D039903:Actinobacteria; D000192:Actinomycetales / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004269:DNA, Bacterial; D004151:Dipeptides; D004926:Escherichia coli / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010802:Phylogeny; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C544515:1,4-dihydroquinoline; C000591437:4-oxo-1,4-dihydroquinoline-3-carboxamide; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004269:DNA, Bacterial; D004151:Dipeptides; D011804:Quinolines; D012336:RNA, Ribosomal, 16S; D062367:ortho-Aminobenzoates; C470014:leucyl-alanine; C067844:N-acetylanthranilic acid; C016810:tryptophylglycine