Preparation of stabilized magnetic nanoparticles with polymerizable lipid and anchor compounds.
Although the lipid-based method for coating of magnetic nanoparticles (MNPs) is rapid and simple, the unstable state of the lipid layer is a major limitation for the practical application of this method. We devised a method to prepare stabilized MNPs by covalent modifications such as lipid polymerization and anchoring of the lipid layer. The stability of the modified lipid layer was demonstrated by the stable status of enzymes immobilized on the MNPs and the resistance of the MNPs to aggregation. We also determined the maximum ratio of nonpolymerizable lipophilic compounds that can be included in the layer without significantly reducing stability.
Department of Chemistry, Gangneung-Wonju National University, Gangneung 210-702, Republic of Korea.
Boram
B
Kang
Department of Chemistry, Gangneung-Wonju National University, Gangneung 210-702, Republic of Korea. Electronic address: sjchoi@gwnu.ac.kr.
Suk-Jung
SJ
Choi
D004800:Enzymes, Immobilized / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D058105:Polymerization
D004800:Enzymes, Immobilized; D008051:Lipid Bilayers; D058185:Magnetite Nanoparticles
Anchor compound; Magnetic nanoparticle; Polymerizable lipid; Surface modification