The role of spacers on the self-assembly of DNA aptamer-amphiphiles into micelles and nanotapes.
The self-assembly of single-stranded DNA (ssDNA) aptamer-amphiphiles was influenced by the choice of spacer used to link the hydrophobic tail and aptamer headgroup. Aptamer-amphiphiles without spacers or with hydrophilic spacers formed globular micelles while amphiphiles with hydrophobic spacers formed bilayer nanotapes, which are the first such structures formed by DNA-amphiphiles.
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy R
TR
Pearce
Brett
B
Waybrant
Efrosini
E
Kokkoli
D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008958:Models, Molecular; D013501:Surface-Active Agents / Q000737:chemistry*
D052157:Aptamers, Nucleotide; D004277:DNA, Single-Stranded; D008823:Micelles; D013501:Surface-Active Agents