Healthy subjects experience bowel changes on enteral diets: addition of a fiber blend attenuates stool weight and gut bacteria decreases without changes in gas.
BACKGROUND
Tube-fed patients frequently suffer from abnormal bowel function that affects intestinal bacteria and quality of life. Dietary fiber affects laxation and can be fermented by gut bacteria to metabolites that influence gut health and fecal moisture. The aim of this study was to compare the effects of a fiber-blend fortified enteral formula (FB, 15 g/L), a fiber-free formula (FF), and habitual diet on bowel function, fecal bacteria, and quality of life.


METHODS
In a randomized, double-blind, crossover design, 20 healthy subjects consumed both FF and FB for 14 days with a 4-week washout. A 5-day fecal collection was used to assess stool output, whole-gut transit time (WGTT), total bacteria, bifidobacteria, lactobacilli, clostridia, and bacteroides. Subject gastrointestinal quality of life index (GIQLI) and side effects were also measured.


RESULTS
On formula diets, 5-day fecal output decreased by >55% from habitual diet, but was 38% higher on FB than FF (P = .0321). WGTT was approximately 1.5 times longer on formula diets than habitual diet (P < .0004). Total bacteria declined from habitual diet on FF (P < .004), but not on FB. Numbers of bifidobacteria and lactobacilli declined from habitual diet on both formula diets, but bifidobacteria was higher on FB compared with FF (P < .0001). Bacteroides and clostridia numbers did not change between diets. GIQLI and incidence of gas symptoms did not differ between formulas.


CONCLUSIONS
Addition of a fiber blend moderated changes in bowel function and gut bacteria observed in healthy subjects consuming FF. These results support adding mixed fiber sources to enteral nutrition if no contraindication exists.
Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota.
Katie J
KJ
Koecher
Department of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
William
W
Thomas
Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota jslavin@umn.edu.
Joanne L
JL
Slavin
D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D003106:Colon / Q000187:drug effects* / Q000382:microbiology; D018592:Cross-Over Studies; D003672:Defecation / Q000187:drug effects*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D004311:Double-Blind Method; D004750:Enteral Nutrition; D005243:Feces / Q000382:microbiology; D005260:Female; D005526:Food, Formulated; D005740:Gases / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D011788:Quality of Life; D055815:Young Adult
D004043:Dietary Fiber; D005740:Gases
enteral formula; fiber; gut function