[Y chromosome microdeletions, chromosome karyotypes and reproductive hormones in patients with azoospermia and severe oligozoospermia].
OBJECTIVE
To study the correlation of azoospermia and severe oligozoospermia with Y chromosome microdeletions, chromosome karyotype and reproductive hormones in male infertility patients.


METHODS
We collected semen samples from 63 patients with azoospermia, 49 with severe oligozoospermia and 60 men with normal semen parameters, and determined the incidence of Y chromosome microdeletions, chromosome karyotypes and the levels of reproductive hormones.


RESULTS
The incidence rate of Y chromosome microdeletions was 11.11% in the azoospermia and 8.16% in the severe oligozoospermia patients, as compared with 0 in the normal controls (P<0.05). The rate of chromosome abnormalities was 9.52% in the azoospermia group, with statistically significant differences from the severe oligozoospermia and normal control men (both 0) (P<0.05). The levels of FSH and LH were significantly higher in the azoospermia ([20.41 +/- 19.34] IU/L and [11.44 +/- 9.48] IU/L) and the severe oligozoospermia patients ([8.88 +/- 7.04] IU/L and [6.78 +/- 3.85] IU/L) than in the normal males ([3.88 +/- 2.21] IU/L and [4.63 +/- 1.51] IU/L) (P<0.05).


CONCLUSIONS
Examinations of genetics and reproductive hormones are necessary for infertile males with azoospermia and severe oligozoospermia, which may contribute to early diagnosis and treatment.
Center for Reproductive Medicine, Huzhou Maternity and Child Health Hospital, Huzhou, Zhejiang 313000, China.
Chun-Ling
CL
Liu
Xiao-Yun
XY
Wu
Hui-Qi
HQ
Qiu
Sheng-Sheng
SS
Shao
Yu-Rong
YR
Zhu
Xiao-Rong
XR
Li
D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D016022:Case-Control Studies; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D006728:Hormones / Q000097:blood; D006801:Humans; D007248:Infertility, Male; D059785:Karyotype; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D012661:Semen; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000097:blood / Q000235:genetics*; D013076:Sperm Count
D006728:Hormones