Generalized pure cutaneous Rosai-Dorfman disease: a link between inflammation and cancer not associated with mitochondrial DNA and SLC29A3 gene mutation?
Recently, we described a case of generalized pure cutaneous Rosai-Dorfman disease in a 43-year-old Asian man in JAMA. The lesions distributed on nearly all of the skin of the whole body, except for mucous sites. Molecular, immunophenotypic, and sequencing analyses seem to define it as a histiocytic-mesenchymal transition and intermediate proliferative histiocytosis not associated with mtDNA large deletion and pathogenic mutation, as well as the SLC29A3 gene mutation.
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Min
M
Zheng
Rui
R
Bi
Wei
W
Li
Lilla
L
Landeck
Jia-Qi
JQ
Chen
Li-Min
LM
Lao
Sui-Qing
SQ
Cai
Yong-Gang
YG
Yao
Xiao-Yong
XY
Man
D004272:DNA, Mitochondrial / Q000235:genetics*; D015618:Histiocytosis, Sinus / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000235:genetics*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D033703:Nucleoside Transport Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction
D004272:DNA, Mitochondrial; D033703:Nucleoside Transport Proteins; C501424:SLC29A3 protein, human