[Pharmacogenetics in the treatment of tobacco addiction].
BACKGROUND
Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies.


OBJECTIVE
To provide an overview of the developments on the pharmacogenetics of the treatment of tobacco addiction.


METHODS
Review article describing the biological processes associated with tobacco addiction, and the influence of genetic variants on smoking behavior and the efficacy of smoking cessation therapies.


RESULTS
Several (combinations of) genetic variants in smoking-related genes influence nicotine dependence. Moreover, several genetic variants in smoking- and treatment-related genes seem to influence the efficacy of smoking cessation therapies which are distinctive for the different forms of pharmacotherapy, especially when they have a different mechanism-of-action.


CONCLUSIONS
Much progress has been made in unraveling the (pharmaco)genetics of tobacco addiction, but much still remains to be done before genetically tailored smoking cessation therapy can be implemented in clinical practice.
M
M
Quaak
F J
FJ
van Schooten
C P
CP
van Schayck
D006801:Humans; D008957:Models, Genetic; D010597:Pharmacogenetics; D016540:Smoking Cessation / Q000379:methods*; D014029:Tobacco Use Disorder / Q000188:drug therapy* / Q000235:genetics*; D016896:Treatment Outcome