Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls.
OBJECTIVE
To investigate if vitamin D deficiency is more prevalent in patients with Paget's disease of bone (PDB) than in age-matched controls.


METHODS
We measured serum 25-OHD in 28 untreated patients with PDB and two control groups: 284 elderly men from an ongoing cohort from our department, and 151 postmenopausal women seen in our outpatient clinic for routine medical evaluation.


RESULTS
The mean ± SD serum 25-OHD was significantly lower in subjects with PDB (23.76 ± 6.29 ng/mL) than in the control groups of elderly men (27.86 ± 13.52 ng/mL) and postmenopausal women (30.30 ± 9.59 ng/mL), p = 0.015. The prevalence of vitamin D deficiency considering a cut-off point of serum 25-OHD < 30 ng/mL was 85.7% in patients with PDB, and in elderly men and postmenopausal women it was 66.7 % and 54.3%, respectively (p < 0.001).


CONCLUSIONS
These results suggest a high prevalence of hypovitaminosis D in patients with Paget's disease living in the tropics.
Luiz
L
Griz
Francisco
F
Bandeira
Erik Trovão
ET
Diniz
Marcelo
M
Cabral
Eduardo
E
Freese
D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications*; D015995:Prevalence; D012189:Retrospective Studies; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
D015652:25-Hydroxyvitamin D 2