The risk of bilobectomy compared with lobectomy: a retrospective analysis of a series of matched cases and controls.
OBJECTIVE
Bilobectomy is considered to be a risky procedure due to space mismatch between the pleural space and the remnant lung. The objective of this study was to evaluate if postoperative complications related or not to size mismatch are more frequent after bilobectomy compared with right lobectomy cases.


METHODS
Retrospective case-control study on a series of matched non-small-cell lung cancer patients. Cases were patients who underwent right bilobectomy (upper and middle or lower and middle) and controls, patients who underwent right upper or lower lobectomy. Cases and controls were matched by propensity scoring according to site, age, ppoFEV1, type of postoperative management (intensive physiotherapy or not), cardiac comorbidity and pT status. We selected two primary outcomes for comparison: occurrence of any cardiorespiratory complication and occurrence of any complication related to space discrepancies. For the latter, all complicated case records were reviewed and two blinded observers agreed on the probability of each complication to be related to space discrepancies. Agreement was measured by the κ statistic. The overall odds ratio (OR) and 95% confidence interval (CI) for each outcome were calculated on 2 × 2 tables for the whole population and for cases with upper or lower resections.


RESULTS
The study included 689 patients: 572 right lobectomy (419 upper and 153 lower) and 117 bilobectomy cases (30 upper and middle and 87 lower and middle). The overall mortality rate of the series was 2.03% (14/689), and cardiorespiratory complications were recorded in 14.4% (99/689) and space-related complications in 19.59% (135/689) cases. Both observers agreed on space-related complications in 86% of the 135 cases (κ: 0.72). After matching, 234 cases entered the study (117 with right lobectomy, including 83 lower and 34 upper, and 117 with bilobectomy, including 87 lower and 30 upper). The prevalence of cardiorespiratory complications was higher after lower and middle lobectomy compared with lower lobectomy (P = 0.0002; OR: 7.96, 95% CI: 2.19-43.16). No differences were found in death rates or in space-related complications between groups of lobectomy and bilobectomy cases.


CONCLUSIONS
This study failed to demonstrate a higher space-related complication rate in bilobectomy cases but cardiorespiratory complications were statistically higher after lower and middle lobectomy compared with lower lobectomy in matched cases.
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.
María Teresa
MT
Gómez
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.
Marcelo Fernando
MF
Jiménez
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.
José Luis
JL
Aranda
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.
María
M
Rodríguez
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.
Nuria María
NM
Novoa
Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain gvs@usal.es.
Gonzalo
G
Varela
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000601:surgery*; D016022:Case-Control Studies; D015505:Chest Tubes; D003428:Cross Infection / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D011013:Pneumonectomy / Q000379:methods* / Q000401:mortality; D011014:Pneumonia / Q000453:epidemiology; D011030:Pneumothorax / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*; D057216:Propensity Score; D001261:Pulmonary Atelectasis / Q000453:epidemiology; D011655:Pulmonary Embolism / Q000453:epidemiology; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012131:Respiratory Insufficiency / Q000453:epidemiology; D012189:Retrospective Studies; D020521:Stroke / Q000453:epidemiology; D055815:Young Adult
30-day mortality; Bilobectomy; Lung resection; Operative morbidity; Postoperative morbidity; Surgical risk