Internal dosimetry estimates using voxelized reference phantoms for thyroid agents.
This work presents internal dosimetry estimates for diagnostic procedures performed for thyroid disorders by relevant radiopharmaceuticals. The organ doses for (131)Iodine, (123)Iodine and (99m)Tc incorporated into the body were calculated for the International Commission on Radiological Protection (ICRP) reference voxel phantoms using the Monte Carlo transport method. A comparison between different thyroid uptakes of iodine in the range of 0-55% was made, and the effect of various techniques for administration of (99m)Tc on organ doses was studied. To investigate the necessity of calculating organ dose from all source regions, the major source organ and its contribution to total dose were specified for each target organ. Moreover, we compared effective dose in ICRP voxel phantoms with that in stylized phantoms. In our method, we directly calculated the organ dose without using the S values or SAFs, as is commonly done. Hence, a distribution of the absorbed dose to entire tissues was obtained. The chord length distributions (CLDs) were also computed for the selected source-target pairs to make comparison across the genders. The results showed that the S values for radionuclides in the thyroid are not sufficient for calculating the organ doses, especially for (123)I and (99m)Tc. The thyroid and its neighboring organs receive a greater dose as thyroid uptake increases. Our comparisons also revealed an underestimation of organ doses reported for the stylized phantoms compared with the values based on the ICRP voxel phantoms in the uptake range of 5-55%, and an overestimation of absorbed dose by up to 2-fold for Iodine administration using blocking agent and for (99m)Tc incorporation.
Physics Department, School of Sciences, Ferdowsi University of Mashhad, Vakilabad Boulevard, Mashhad, 91775-1436, Iran.
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Hoseinian-Azghadi
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Rafat-Motavalli
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Miri-Hakimabad
D065638:Absorption, Radiation; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000592:standards*; D007492:Iran; D008954:Models, Biological; D009928:Organ Specificity; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000592:standards*; D051598:Whole Body Imaging / Q000592:standards*
D019275:Radiopharmaceuticals
Monte-Carlo method; internal dosimetry; thyroid agents; voxel phantoms