[Neuropathic pain: pathophysiology, assessment, and therapy].
Neuropathic pain is caused by lesions in the somatosensory system. Characteristic but not exclusive features are spontaneous burning pain, electrifying and shooting pain, hyperalgesia, and allodynia. The basic concept of the pathophysiology of neuropathic pain is the combination of peripheral and central sensitization. Knowledge on the molecular mechanisms has grown exponentially in recent years. The problem lies in identifying the individual mechanisms and in determining a comprehensive concept. Progress has also been made in assessment, e.g., methods for detecting dysfunction of nociceptors have significantly improved. In addition, there are many more therapeutic options available than 15 years ago. The drugs available include antidepressants, anticonvulsants, opioids, and topical medications. Data from controlled trials and recommendations from guidelines are available.
Neurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland, sommer@uni-wuerzburg.de.
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D000700:Analgesics / Q000627:therapeutic use; D059333:Central Nervous System Sensitization / Q000502:physiology; D003131:Combined Modality Therapy; D006801:Humans; D009437:Neuralgia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D009619:Nociceptors / Q000502:physiology; D010147:Pain Measurement; D013003:Somatosensory Cortex / Q000503:physiopathology; D004561:Transcutaneous Electric Nerve Stimulation
D000700:Analgesics