Combining cellular and gene therapy approaches for treatment of intracranial tumors.
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
Department of Neurosurgery; University of California Los Angeles; Los Angeles, CA USA.
Michelle J
MJ
Hickey
Noriyuki
N
Kasahara
Barbara M
BM
Mueller
Carol A
CA
Kruse
alloCTL; brain cancer; breast cancer; gene therapy; immunotherapy; metastasis; retrovirus