Implications for human papillomavirus in penile cancer.
Human papillomavirus infection (HPV) has been implicated in penile cancer, and although the annual incidence is estimated to be 1,570 in the United States, there are areas of the world in which the incidence is as much as 20-fold higher. Ample data in the literature support testing and vaccination against HPV-related cervical cancer, but for men and penile cancer, these data are lacking. However, some preliminary data would suggest that HPV not only plays an important role in a significant subset of patients with penile cancer but also may be a target for penile cancer prevention as well via initiation of a vaccination program in high-risk male populations.
Department of Hematology Oncology, University of South Florida, Tampa, FL.
Amber
A
Flaherty
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
Timothy
T
Kim
Department of Infectious Disease and Research, Moffitt Cancer Center, Tampa, FL.
Anna
A
Giuliano
Department of Pathology, Moffitt Cancer Center, Tampa, FL.
Anthony
A
Magliocco
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
Tariq S
TS
Hakky
Department of Genitourinary Medical Oncology, University of Texas, MD Anderson Cancer Center, Tampa, FL.
Lance C
LC
Pagliaro
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL. Electronic address: philippe.spiess@moffitt.org.
Philippe E
PE
Spiess
D052685:Alphapapillomavirus / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines / Q000276:immunology* / Q000627:therapeutic use; D010412:Penile Neoplasms / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D010413:Penis / Q000276:immunology / Q000473:pathology / Q000821:virology; D011379:Prognosis; D012307:Risk Factors
D053918:Papillomavirus Vaccines
Human papillomavirus; Penile cancer; Vaccination