Syndrome of inappropriate secretion of antidiuretic hormone due to selective serotonin reuptake inhibitors after pancreaticoduodenectomy for carcinoma of the ampulla of Vater: case report.
A 68-year-old man underwent pancreaticoduodenectomy with lymph nodes dissection for carcinoma of the ampulla of Vater. The patient had anxiety neurosis and had been treated with a selective serotonin reuptake inhibitor (SSRI). Postoperatively, SSRI was resumed on postoperative day 2. His serum sodium concentration gradually decreased, and the patient was given a sodium supplement. However, 11 days after the operation, laboratory findings included serum sodium concentration of 117 mEq/L, serum vasopressin of 2.0 pg/mL, plasma osmolality of 238 mOsm/kg, urine osmolality of 645 mOsm/kg, urine sodium concentration of 66 mEq/L, serum creatinine concentration of 0.54 mg/dL, and serum cortisol concentration of 29.1 μg/dL. With a diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH), the antianxiety neurosis medication was changed from the SSRI to another type of drug. After switching the medication, the patient made a satisfactory recovery with normalization of serum sodium by postoperative day 20.
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Ryota
R
Iwase
Hiroaki
H
Shiba
Takeshi
T
Gocho
Yasuro
Y
Futagawa
Shigeki
S
Wakiyama
Yuichi
Y
Ishida
Takeyuki
T
Misawa
Katsuhiko
K
Yanaga
D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology* / Q000601:surgery; D001008:Anxiety Disorders / Q000188:drug therapy*; D001569:Benzodiazepines / Q000627:therapeutic use; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008197:Lymph Node Excision; D008297:Male; D016577:Pancreaticoduodenectomy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D001569:Benzodiazepines; D017367:Selective Serotonin Reuptake Inhibitors