[Effect of microemulsion technology on release of compounds in Zhitong cataplasm and content variation].
To study the varieties of adhesives in gels on the basis of previous studies, dosage of adhesives required for forming of gels by using the single factor design, as well as the drug loading capacity of gels with the adhesiveness and stickiness as the scoring indicators, in order to determine the forming method of analgesic micro-emulsion gel. Subsequently, the improved Franz diffusing cell method was adopted to study the release of water-soluble components and liposoluble components in analgesic gels, with imperatorin and ferulic acid as index components. The results showed that analgesic micro-emulsion gel could promote the release of imperatorin and ferulic acid. Finally, HPLC was used to detect that the loss amount of volatile components in analgesic micro-emulsion gel was 23.13% lower than that in the original analgesic gel. In the experiment, we finally prepared finished products of micro-emulsion gel, discovered that the micro-emulsion technology is helpful to improve the synchronous release of water-soluble components and liposoluble components in prescriptions and can reduce the loss of volatile components.
Beijing University of Chinese Medicine, Beijing 100102, China.
Xue-Min
XM
Li
Qiong
Q
Wang
Yi
Y
Lan
Jing
J
An
Wen-Ping
WP
Wang
Bo-Chen
BC
Zhao
Qing
Q
Wu
D000268:Adhesiveness; D000700:Analgesics / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000627:therapeutic use; D004655:Emulsions; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D009824:Ointments; D010146:Pain / Q000188:drug therapy*
D000700:Analgesics; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D009824:Ointments