Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis.
The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+cells correlates with improved patient survival independently of other histopathological parameters, including disease stage.
Department of Surgery; University Hospital Basel; Basel, Switzerland ; Institute of Surgical Research and Hospital Management (ICFS) and Department of Biomedicine; University of Basel; Basel, Switzerland.
Christian
C
Hirt
Serenella
S
Eppenberger-Castori
Giuseppe
G
Sconocchia
Giandomenica
G
Iezzi
Luigi
L
Tornillo
Luigi
L
Terracciano
Giulio C
GC
Spagnoli
Raoul A
RA
Droeser
CD15; human colorectal cancer; mismatch repair status; myeloperoxidase; prognosis; tissue microarray