[Study on drug release performance of compound Nanxing pain pastes with different stromata].
Solvent and emulsion pressure-sensitive patches for compound Nanxing pain paste were prepared respectively in this study. Franz diffusion cell method was adopted to determine in vitro release of eugenol in compound Nanxing pain paste of the two stromata, with microfiltration membranes in place of skins. The results of the experiment demonstrated that solvent pressure-sensitive patches were superior to emulsion pressure-sensitive patches in terms of the accumulated release percentage of eugenol, with both of their release processes in line with Higuchi model and non-Fick diffusion mechanism. In conclusion, emulsion pressure-sensitive stroma was more beneficial to in vitro release of eugenol in compound Nanxing pain paste.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Ying
Y
Li
Shou-Ying
SY
Du
Yong
Y
Ma
Yang
Y
Lu
Ke-Xin
KX
Shang
D000700:Analgesics / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008954:Models, Biological; D009824:Ointments; D010146:Pain / Q000188:drug therapy*; D011312:Pressure
D000700:Analgesics; D004365:Drugs, Chinese Herbal; D009824:Ointments; C585598:nanxing