Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase.
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139 (USA).
Chi
C
Zhang
Alexander M
AM
Spokoyny
Yekui
Y
Zou
Mark D
MD
Simon
Bradley L
BL
Pentelute
D002384:Catalysis; D057930:Click Chemistry; D003545:Cysteine / Q000737:chemistry*; D005982:Glutathione Transferase / Q000737:chemistry*; D006801:Humans; D010455:Peptides; D011499:Protein Processing, Post-Translational
D010455:Peptides; D005982:Glutathione Transferase; D003545:Cysteine
bioconjugation; click chemistry; cysteine arylation; enzyme catalysis; peptide macrocyclization