Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies.
Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration >20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages.
Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.
Christina L
CL
Marino
Comparative Pain Research Laboratory, Surgery Section, Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA.
B Duncan X
BD
Lascelles
Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA.
Shelly L
SL
Vaden
Comparative Pain Research Laboratory, Surgery Section, Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Comparative Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.
Margaret E
ME
Gruen
Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA steve_marks@ncsu.edu.
Steven L
SL
Marks
D000367:Age Factors; D000818:Animals; D002371:Cat Diseases / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology; D002415:Cats; D010003:Osteoarthritis / Q000145:classification / Q000453:epidemiology / Q000662:veterinary*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000145:classification / Q000453:epidemiology / Q000662:veterinary*; D012189:Retrospective Studies; D012307:Risk Factors