A 0.18 μm biosensor front-end based on 1/f noise, distortion cancelation and chopper stabilization techniques.
This paper presents a novel sensor front-end circuit that addresses the issues of 1/f noise and distortion in a unique way by using canceling techniques. The proposed front-end is a fully differential transimpedance amplifier (TIA) targeted for current mode electrochemical biosensing applications. In this paper, we discuss the architecture of this canceling based front-end and the optimization methods followed for achieving low noise, low distortion performance at minimum current consumption are presented. To validate the employed canceling based front-end, it has been realized in a 0.18 μm CMOS process and the characterization results are presented. The front-end has also been tested as part of a complete wireless sensing system and the cyclic voltammetry (CV) test results from electrochemical sensors are provided. Overall current consumption in the front-end is 50 μA while operating on a 1.8 V supply.
Viswanathan
V
Balasubramanian
Pierre-Francois
PF
Ruedi
Yuksel
Y
Temiz
Anna
A
Ferretti
Carlotta
C
Guiducci
Enz
D000669:Amplifiers, Electronic; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design / Q000295:instrumentation*; D009622:Noise