Neurocutaneous melanosis in children with giant congenital melanocytic nevi.
Twenty-four children with giant congenital melanocytic nevi underwent brain MRI at 1.5 T scanner. Melanin deposits in the brain were found in seven children (29.2%) located in temporal lobes, thalamus, cerebellum, and pons. One patient showed leptomeningeal involvement. Six patients were asymptomatic, and one had epilepsy. As opposed to previous reports, localization of skin nevi on anterior part of trunk was correlated to central nervous system involvement. In all patients with brain involvement skin nevi showed picture of compound nevus with neurofibromatic component.
Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland. Electronic address: zaklad.rtg@imid.med.pl.
Monika
M
Bekiesinska-Figatowska
Clinic of Surgery of Children and Adolescents, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Orest
O
Szczygielski
Clinic of Surgery of Children and Adolescents, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Maria
M
Boczar
Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Jaroslaw
J
Madzik
Department of Pathology, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Teresa
T
Klepacka
Department of Pathology, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Elzbieta
E
Michalak
Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Anna
A
Romaniuk-Doroszewska
Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Maria
M
Uliasz
Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Pawel
P
Peczkowski
Clinic of Surgery of Children and Adolescents, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw, Poland.
Ewa
E
Sawicka
D001921:Brain / Q000378:metabolism / Q000473:pathology; D001931:Brain Mapping; D002531:Cerebellum / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008548:Melanosis / Q000150:complications / Q000473:pathology*; D020752:Neurocutaneous Syndromes / Q000150:complications / Q000473:pathology*; D009508:Nevus, Pigmented / Q000150:complications / Q000473:pathology*; D011149:Pons / Q000378:metabolism; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*; D013702:Temporal Lobe / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism
D008543:Melanins
Central nervous system (CNS); Giant congenital melanocytic nevi (GCMN); Magnetic resonance imaging (MRI); Neurocutaneous melanosis (NCM); Pathology