Deciphering laminar-specific neural inputs with line-scanning fMRI.
Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-μm) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
Xin
X
Yu
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
Chunqi
C
Qian
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
Der-yow
DY
Chen
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
Stephen J
SJ
Dodd
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.
Alan P
AP
Koretsky
D000465:Algorithms; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000737:chemistry; D009044:Motor Cortex / Q000473:pathology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D055095:Optics and Photonics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D008345:Manganese