Use of electrochemotherapy in a case of neck skin metastasis of oral squamous cell carcinoma: case report and considerations.
BACKGROUND
Squamous cell carcinoma (SCC) is the most common oral cavity malignant tumor. Surgery, radiotherapy, and chemotherapy have been the major options for its treatment. Electrochemotherapy (ECT) is a novel local treatment successfully used in secondary or primary skin or subcutaneous tumors. This new cancer treatment is a modality in which a locally applied electrical field enhances cell membrane permeability, thereby allowing greater intracellular accumulation of a chemotherapeutic agent.


METHODS
We report a case of a man affected by an ulcerated SCC. The man was treated with ECT with good results.


RESULTS
In our case, ECT was successful in the management of extensive metastasis of SCC in clinical conditions, whereas other approaches were rejected.


CONCLUSIONS
This case shows good clinical results; however, other studies are necessary to show that ECT should be considered as a promising treatment option.
Organ of Sense Department - ENT Section, University of Rome "Sapienza,", Rome, Italy.
Gian Franco
GF
Macri
Antonio
A
Greco
Andrea
A
Gallo
Massimo
M
Fusconi
Caterina
C
Marinelli
Marco
M
de Vincentiis
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000628:therapy*; D053672:Electrochemotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin
bleomycin; electrochemotherapy; neck; oral cancer; skin metastasis