Peptide receptor radionuclide therapy with (177)Lu DOTATATE in a case of recurrent carotid body paraganglioma with spinal metastases.
Paragangliomas are rare benign neuroendocrine tumors, and 80% of all paragangliomas are either carotid body tumors or glomus jugulare tumors. We present a case of recurrent unresectable carotid body paraganglioma with nodal and T7 vertebral metastases in a 30-year-old man 6 years postsurgery detected with Ga DOTANOC PET/CT and was administered with peptide receptor radionuclide therapy using Lu DOTATATE. After 5 cycles of Lu DOTATATE (total cumulative activity of 750 mCi [27 GBq]), significant response at the primary site on Ga DOTANOC PET/CT and complete disappearance of nodal and T7 vertebral metastases were noted.
From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Santosh Kumar
SK
Gupta
Suhas
S
Singla
Sellam
S
Karunanithi
Nishikant
N
Damle
Chandrasekhar
C
Bal
D000328:Adult; D002345:Carotid Body Tumor / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010235:Paraganglioma / Q000150:complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013125:Spinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000556:secondary*
D009942:Organometallic Compounds; C447941:lutetium Lu 177 dotatate; D015282:Octreotide