Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential.
The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potential was examined. Compounds 1 and 8 prevented elevation of ROS induced by t-BOOH, suggesting the potential activity of these compounds to protect fibroblasts from oxidative stress.
Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey.
Nilüfer
N
Denizli
Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey.
Ibrahim
I
Horo
Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey.
Derya
D
Gülcemal
Salerno University, Department of Pharmacia, 84084 Fisciano, Salerno, Italy.
Milena
M
Masullo
Salerno University, Department of Pharmacia, 84084 Fisciano, Salerno, Italy.
Michela
M
Festa
Salerno University, Department of Pharmacia, 84084 Fisciano, Salerno, Italy.
Anna
A
Capasso
Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey; Bursa Technical University, Faculty of Natural Sciences, Architecture and Engineering, Department of Chemistry, Osmangazi, Bursa, Turkey.
Ömer
Ö
Koz
Salerno University, Department of Pharmacia, 84084 Fisciano, Salerno, Italy. Electronic address: piacente@unisa.it.
Sonia
S
Piacente
Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey. Electronic address: ozgen.alankus.caliska@ege.edu.tr.
Özgen
Ö
Alankuş-Çalışkan
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027883:Astragalus Plant / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D006027:Glycosides; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D014315:Triterpenes; C085352:cycloartane
Antioxidant activity; Astragalus plumosus var. krugianus; Cycloartane glycosides; Fibroblasts