Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC).
A complete blood cell count (CBC) is a frequent test sent to aid in the diagnostic evaluation of ill patients. Not uncommonly hematologic abnormalities may be the first sign of an underlying systemic disorder. The astute clinician needs to understand how systemic disease can affect the CBC to direct further diagnostic investigations. This article focuses on the 2 most common acquired anemias including iron deficiency and anemia of inflammation as well as disseminated intravascular coagulation.
Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3501 Civic Center Boulevard, CTRB 11th Floor, Room 11-026, Philadelphia, PA 19104, USA. Electronic address: witmer@email.chop.edu.
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Witmer
D000740:Anemia / Q000175:diagnosis* / Q000188:drug therapy; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D001772:Blood Cell Count; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007249:Inflammation
Anemia of inflammation; Disseminated intravascular coagulation; Function of hemoglobin; Iron deficiency anemia