Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune polyglandular syndrome type 3 variant; APS3v), and were treated with intensive insulin therapy and anti-thyroid drugs. Human leukocyte antigen examinations showed that both cases had the HLA-A2, A24, B54, and DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype, which made them susceptible not only to APS3v, but also to both acute-onset T1D and GD. The genetic background of patients strongly contributes to the simultaneous occurrence of T1D and GD.
Division of Endocrinology and Metabolism, St. Mary's Hospital, Japan.
Tetsuya
T
Mizokami
Ayumi
A
Yamauchi
Yuichi
Y
Sato
Masae
M
Toyonaga
Hirofumi
H
Imoto
Hiroto
H
Kojima
Hiroh
H
Saji
Kiyohide
K
Nunoi
D000328:Adult; D044466:Asian People / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000150:complications* / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007564:Japan; D016884:Polyendocrinopathies, Autoimmune / Q000235:genetics* / Q000276:immunology / Q000628:therapy
D006680:HLA Antigens