Elastin-like polypeptides and their applications in anticancer drug delivery systems: a review.
Elastin-like polypeptides (ELPs) are large molecular weight biopolymers. They have been widely studied as macromolecular carriers for targeted delivery of drugs. The aim of the present article is to review the available information on ELPs (including our recent investigations), their properties, drug delivery applications to tumor sites and future perspectives. This review also provides information on the use of short synthetic ELPs for making ELP-drug conjugates, for targeted delivery of anticancer drugs. In the present review we also focus on the point that short ELPs can also be used for targeting anticancer drugs to tumor sites as they behave similar to long ELPs regarding their capacity to undergo inverse temperature transition (ITT) behavior.
TIFAC CORE HD, J.S.S. College of Pharmacy (Off Campus, JSS University, Mysore) , Ootacamund, Tamil Nadu , India.
Rubha
R
Saxena
Moola Joghee
MJ
Nanjan
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D001702:Biopharmaceutics / Q000639:trends; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004549:Elastin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D008970:Molecular Weight; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000639:trends; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D015202:Protein Engineering / Q000639:trends; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D012995:Solubility
D000970:Antineoplastic Agents; D004337:Drug Carriers; D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D011994:Recombinant Proteins; D004549:Elastin
Cancer chemotherapy; drug delivery; drug targeting; elastin; elastin-like polypeptides