Deciphering the role of natural variation in age-related protein homeostasis.
Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.See research article: http://www.biomedcentral.com/1741-7007/11/100.
Department of Pathology, University of Washington, 1959 NE Pacific Street, D-514, Seattle, WA 98195-7470, USA. kaeber@uw.edu.
Matt
M
Kaeberlein
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D004195:Disease Models, Animal; D014644:Genetic Variation; D019636:Neurodegenerative Diseases / Q000235:genetics*; D010455:Peptides / Q000235:genetics*
D010455:Peptides; C097188:polyglutamine