Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats.
Polyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.
School of Studies in Neuroscience, Jiwaji University, Gwalior 474 011, India.
Nisha
N
Patro
Kavita
K
Singh
Ishan
I
Patro
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000494:pharmacology; D001253:Astrocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007249:Inflammation / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D017628:Microglia / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D011070:Poly I-C / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000998:Antiviral Agents; D005904:Glial Fibrillary Acidic Protein; D008070:Lipopolysaccharides; D011070:Poly I-C