[Evaluation of liberation of caffeine from dermal semisolids drugs].
The paper deals with formulation of caffeine into dermal semisolid dosage forms - hydrogels. Caffeine was chosen as a model drug because its properties can be successfully used just in hydrogels. Protective and tranquilization effects can be used in the preparations for sunbathing, and its lipolytic and regenerative effect can be used for the treatment of androgenic alopecia or cellular bioprotection. The aim of the study was to investigate the influence of different concentrations of chitosan and caffeine on the liberation of gels. Besides, stability of the prepared samples was evaluated by means of the evaluation of their rheological parameters. Based on the obtained results, there was determined the optimal drug concentration - caffeine 0.2% (w/w) and also the gel forming substance - chitosan 2.3% (w/w).
Alexandra
A
Kodadová
Zuzana
Z
Vitková
Petra
P
Herdová
D002110:Caffeine / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D048271:Chitosan / Q000737:chemistry*; D065546:Drug Liberation; D005782:Gels; D020100:Hydrogels; D012212:Rheology
D005782:Gels; D020100:Hydrogels; D002110:Caffeine; D048271:Chitosan