Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder.
Findings on the association between the risk for developing bipolar disorder and the functions of the serotonin transporter-linked polymorphic region gene (5-HTTLPR) and dopamine D2 receptor gene (DRD2) variants are contradictory. One explanation for this is that a gender difference may exist for genetic contributions. We compared the gender-related main effects and the gene-to-gene interaction between serotonin transporter gene (SLC6A4) and DRD2 in adult male and female patients with bipolar I (BP-I) and bipolar II (BP-II) disorder. Patients with BP-I (n = 400) and BP-II (n = 493), and healthy controls (n = 442) were recruited from Taiwan's Han Chinese population. The genotypes of the 5-HTTLPR and DRD2 Taq-IA polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant gender-specific association of the DRD2 A1/A1 and the 5-HTTLPR S/S, S/LG , and LG/LG (S+) (p = 0.01) genotypes in men with BP-I (p = 0.002 and 0.01, respectively) and BP-II (p = 0.001 and 0.007, respectively), but not in women. A significant interaction for the DRD2 A1/A1 and 5-HTTLPR S+ polymorphisms was also found only in men with BP-I and BP-II (p = 0.003 and 0.001, respectively). We provide preliminary evidence for a gender-specific effect of the SLC6A4 and DRD2 gene variants for the risk of BP-I and of BP-II. We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder.
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Tzu-Yun
TY
Wang
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Sheng-Yu
SY
Lee
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shiou-Lan
SL
Chen
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yun-Hsuan
YH
Chang
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shih-Heng
SH
Chen
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
San-Yuan
SY
Huang
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Nian-Sheng
NS
Tzeng
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen-Lin
CL
Wang
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Pin-Hsi
PH
Yeh
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Kao Chin
KC
Chen
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
I Hui
IH
Lee
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Tzung Lieh
TL
Yeh
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Yen Kuang
YK
Yang
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Ru-Band
RB
Lu
D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001714:Bipolar Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012727:Sex Characteristics; D013624:Taiwan / Q000208:ethnology; D055815:Young Adult
C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins