Striking similarities in genetic aberrations between a rectal tumor and its lung recurrence.
We are reporting on a colorectal cancer patient with the longest disease-free interval ever published, where chromosomal microarray analysis was used to confirm the link between the primary and metastatic lesions. This rare case reports on a patient with late recurrence of colorectal cancer in the lung 19 years after its initial diagnosis. We used high-resolution array CGH (aCGH) to analyze the genetic aberrations of both the primary rectal and the recurrent metastatic lung lesions. Interestingly, we found striking similarities between the two lesions, despite the 19 years disease-free interval. In addition, most of the genes that were previously reported to be associated with a high recurrence score showed copy number gains by aCGH in one or both lesions. Our findings suggest that aCGH may be a helpful tool in analyzing the origin of metastases and underline the need for a better understanding of the characteristics of rectal tumors that have a late recurrence potential.
Osama E Rahma, Mauricio Burotto, Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892, United States.
Osama E
OE
Rahma
Mauricio
M
Burotto
Luisa Matos
LM
Do Canto
Alexandre A
AA
Germanos
Bassem R
BR
Haddad
John L
JL
Marshall
Colorectal cancer; Delayed; Genetic aberrations; High-resolution array CGH.; Recurrence