Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.
The immunomodulatory role of vitamin D in many diseases is well established. However, the relationship between vitamin D status and skin cancers is unclear. In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies.
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
Ryan M
RM
Trowbridge
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
Mario V
MV
Mitkov
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
William J
WJ
Hunter
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA. Electronic address: dkagr@creighton.edu.
Devendra K
DK
Agrawal
D000818:Animals; D051940:B7-2 Antigen / Q000378:metabolism*; D005260:Female; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism*; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D013552:Swine; D014808:Vitamin D Deficiency / Q000150:complications* / Q000378:metabolism
D051940:B7-2 Antigen; D016328:NF-kappa B; D018167:Receptors, Calcitriol
CD86; Cutaneous melanoma; Cutaneous squamous cell carcinoma; NF-κB; Vitamin D; Vitamin D receptor