Enantioselective desymmetrization of prochiral 1,3-dinitropropanes via organocatalytic allylic alkylation.
An enantioselective desymmetrization of prochiral 1,3-dinitropropanes has been developed which proceeds via enantiogroup differentiating organocatalytic allylic alkylation. Densely functionalized products with two vicinal stereocenters were obtained generally with good to excellent diastereoselectivity (up to >20 : 1 dr) and superb enantioselectivity (up to >99 : 1 er).
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. sm@orgchem.iisc.ernet.in.
Soumya Jyoti
SJ
Singha Roy
Santanu
S
Mukherjee