Dissecting apoptosis the omics way.
A combined analysis of transcription, translation and protein degradation reveals the global effects of an anticancer drug on tumour cells.
Petra Van Damme is at the Department of Medical Protein Research, VIB, and Department of Biochemistry, Ghent University, Ghent, Belgium petra.vandamme@vib-ugent.be.
Petra
P
Van Damme
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D004268:DNA-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D000076249:Heat Shock Transcription Factors; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*; D011480:Protease Inhibitors / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D014157:Transcription Factors / Q000235:genetics*
D000970:Antineoplastic Agents; D001897:Boronic Acids; D004268:DNA-Binding Proteins; D000076249:Heat Shock Transcription Factors; D011480:Protease Inhibitors; D011719:Pyrazines; D014157:Transcription Factors; D000069286:Bortezomib
apoptosis; caspase; myeloma; proteomics; ribosome profiling