Cardiovascular disease among breast cancer survivors: the call for a clinical vascular health toolbox.
With better detection and treatment, breast cancer is less likely to be the primary cause of death in the majority of breast cancer survivors; mortality due to cardiovascular disease (CVD) is now more common. Given the long latency periods between cancer treatment completion and potential symptomatic CVD, there is a need to detect vascular changes before symptoms appear. This short review provides an overview of non-invasive, widely available, and relatively inexpensive techniques for assessing endothelial function, central and regional arterial stiffness, central blood pressures, and intima-media thickness. These tools exhibit acceptable reliability and validity, and are relatively practical. Clinical assessment recommendations are also provided. There is sufficient evidence to encourage the use of these techniques as a component of routine serial assessments, and to help guide appropriate treatment strategies.
Exercise Prescription Clinic, School of Physical Education, Sport and Exercise Sciences, University of Otago, PO Box 56, Dunedin, New Zealand, lynnette.jones@otago.ac.nz.
Lynnette M
LM
Jones
Lee
L
Stoner
Casey
C
Brown
Chris
C
Baldi
Blair
B
McLaren
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D012306:Risk; D017741:Survivors
D000970:Antineoplastic Agents