Quercetin inhibits inflammatory bone resorption in a mouse periodontitis model.
Periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. The development of aggressive periodontitis has been associated with increased inflammatory response that is induced by the presence of a subgingival biofilm containing Aggregatibacter actinomycetemcomitans. The flavonoid quercetin (1) is widespread in vegetables and fruits and exhibits many biological properties for possible medical and clinical applications such as its anti-inflamatory and antioxidant effects. Thus, in the present study, the properties of 1 have been evaluated in bone loss and inflammation using a mouse periodontitis model induced by A. actinomycetemcomitans infection. Subcutaneous treatment with 1 reduced A. actinomycetemcomitans-induced bone loss and IL-1β, TNF-α, IL-17, RANKL, and ICAM-1 production in the gingival tissue without affecting bacterial counts. These results demonstrated that quercetin exhibits protective effects in A. actinomycetemcomitans-induced periodontitis in mice by modulating cytokine and ICAM-1 production.
Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center , 13045-755 Campinas, Brazil.
Marcelo H
MH
Napimoga
Juliana T
JT
Clemente-Napimoga
Cristina G
CG
Macedo
Fabiana F
FF
Freitas
Rafael N
RN
Stipp
Felipe A
FA
Pinho-Ribeiro
Rubia
R
Casagrande
Waldiceu A
WA
Verri
D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity*; D016301:Alveolar Bone Loss / Q000139:chemically induced / Q000382:microbiology; D000818:Animals; D001862:Bone Resorption / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010518:Periodontitis / Q000276:immunology*; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D020381:Interleukin-17; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D011794:Quercetin