Antimicrobial activity and chemical analysis of Microlicia hatschbachii Wurdack (Melastomataceae) extract.
Aerial parts of Microlicia hatschbachii were extracted with hexane, and the extract was evaluated for antimicrobial activity by a broth dilution method. After phytochemical procedures: GC-MS identified aliphatic alkanes, carboxylic acids and methyl esters of long-chain fatty acids; and two diterpenoids [labd-8(17)-en-15-oic acid and labd-8(17),13-dien-15-oic acid] were identified by (1)H and (13)C NMR. The antimicrobial activity of the hexane extract could be attributed to the presence of labdanes. This identification is the first reported occurrence of labdane diterpenes in the Melastomataceae family.
a Phytochemistry Laboratory , State University of Feira de Santana , 44036-900 Feira de Santana , Bahia , Brazil.
Dayse S A
DS
Cassiano
Alessandra G M
AG
Pacheco
Mateus M
MM
da Costa
Jackson R G S
JR
Almeida
Ivo J C
IJ
Vieira
Alexsandro
A
Branco
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D006586:Hexanes / Q000737:chemistry; D035322:Melastomataceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000890:Anti-Infective Agents; D004224:Diterpenes; D005227:Fatty Acids; D006586:Hexanes; C518472:labd-8 (17)-en-15-oic acid; C000591435:labd-8(17),13-dien-15-oic acid; C026385:n-hexane