The ambulatory arterial stiffness index and target-organ damage in Chinese patients with chronic kidney disease.
BACKGROUND
The ambulatory arterial stiffness index (AASI) can be used to predict cardiovascular morbidity and mortality in hypertensive patients. However, data on AASI in Chinese patients with chronic kidney disease (CKD) is not available.


METHODS
This cross-sectional study enrolled 583 CKD patients. Univariate and multivariate analyses were used to evaluate the relationship between AASI and renal function and parameters of cardiovascular injury.


RESULTS
Patients with a higher AASI had a higher systolic blood pressure, a lower estimated glomerular filtration rate (eGFR), a higher serum cystatin C, a higher left ventricular mass index (LVMI) and carotid intima-media thickness (cIMT). Univariate analyses showed that AASI was positively correlated with serum cystatin C (r=0.296, P < 0.001), serum creatinine (r=0.182, P < 0.001), and LVMI (r = 0.205, P < 0.001) and negatively correlated with the eGFR (r = -0.200, P < 0.001). Multivariate analyses revealed that serum cystatin C, eGFR, serum creatinine and LVMI were independently correlated with AASI.


CONCLUSIONS
These data suggest that AASI was closely correlated with renal function and parameters of cardiovascular injury in Chinese CKD patients. Good quality, long-term, large longitudinal trials to validate the role of AASI in clinical practice for Chinese CKD patients.
Cheng
C
Wang
Jun
J
Zhang
Cui-Cui
CC
Li
Wen-Yu
WY
Gong
Xun
X
Liu
Zeng-Chun
ZC
Ye
Hui
H
Peng
Division of Nephrology, Department of medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, China. lou.tq@163.com.
Tan-Qi
TQ
Lou
D000328:Adult; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000401:mortality*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000401:mortality*; D007677:Kidney Function Tests; D008297:Male; D018670:Monitoring, Ambulatory / Q000706:statistics & numerical data; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000401:mortality*; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D059289:Vascular Stiffness