Viral and Cellular Components of AAV2 Replication Compartments.
Adeno-associated virus 2 (AAV2) is a helpervirus-dependent parvovirus with a bi-phasic life cycle comprising latency in absence and lytic replication in presence of a helpervirus, such as adenovirus (Ad) or herpes simplex virus type 1 (HSV-1). Helpervirus-supported AAV2 replication takes place in replication compartments (RCs) in the cell nucleus where virus DNA replication and transcription occur. RCs consist of a defined set of helper virus-, AAV2-, and cellular proteins. Here we compare the profile of cellular proteins recruited into AAV2 RCs or identified in Rep78-associated complexes when either Ad or HSV-1 is the helpervirus, and we discuss the potential roles of some of these proteins in AAV2 and helpervirus infection.
Institute of Virology, University of Zurich, Winterthurerstr. 266a, CH-8057 Zurich, Switzerland.
Rebecca
R
Vogel
Michael
M
Seyffert
Bruna de Andrade
Bde A
Pereira
Cornel
C
Fraefel
AAV2; HSV-1; adenovirus; replication compartments.