Integrative data-mining tools to link gene and function.
Information derived from genomic and post-genomic data can be efficiently used to link gene and function. Several web-based platforms have been developed to mine these types of data by integrating different tools. This method paper is designed to allow the user to navigate these platforms in order to make functional predictions. The main focus is on phylogenetic distribution and physical clustering tools, but other tools such as pathway reconstruction, gene fusions, and analysis of high-throughput experimental data are also surveyed.
Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.
Basma
B
El Yacoubi
Valérie
V
de Crécy-Lagard
D000818:Animals; D002874:Chromosome Mapping; D016000:Cluster Analysis; D057225:Data Mining / Q000379:methods*; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D056726:Genetic Association Studies; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008957:Models, Genetic; D058977:Molecular Sequence Annotation; D010641:Phenotype; D010802:Phylogeny; D025941:Protein Interaction Mapping; D012045:Regulatory Sequences, Nucleic Acid; D012984:Software