Immunity, inflammation and cancer: a leading role for adenosine.
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic processes. Adenosine is an ancient extracellular signalling molecule that can regulate almost all aspects of tissue function. As such, several studies have recently highlighted a crucial role for adenosine signalling in regulating the various aspects of cell-intrinsic and cell-extrinsic processes of cancer development. This Review critically discusses the role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease.
1] Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy. [2] Department of Surgery and Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Luca
L
Antonioli
Corrado
C
Blandizzi
Pál
P
Pacher
György
G
Haskó
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000502:physiology; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000276:immunology
D018836:Inflammation Mediators; D018047:Receptors, Purinergic P1; D020928:Mitogen-Activated Protein Kinases; D000241:Adenosine