Examination of aggression and self-injury in children with autism spectrum disorders and serious behavioral problems.
This study identified subtypes of aggression in a sample of 206 children with autism spectrum disorder (ASD) who participated in 2 risperidone trials. The narratives were derived from a parent interview about each child's 2 most pressing problems. Five subtypes of aggression emerged: hot aggression only, cold aggression only, self-injurious behavior (SIB) only, aggression and SIB, and nonaggressive. All groups showed a high rate of positive response to risperidone with no differences across subtypes. These study findings extend understanding of aggression in ASD and may be useful to guide further study on biological mechanisms and individualized treatment in ASD.
Family & Children's Aid, Danbury, CT, USA.
Devon
D
Carroll
Victoria
V
Hallett
Christopher J
CJ
McDougle
Michael G
MG
Aman
James T
JT
McCracken
Elaine
E
Tierney
L Eugene
LE
Arnold
Denis G
DG
Sukhodolsky
Luc
L
Lecavalier
Benjamin L
BL
Handen
Naomi
N
Swiezy
Cynthia
C
Johnson
Karen
K
Bearss
Benedetto
B
Vitiello
Lawrence
L
Scahill
D000293:Adolescent; D000374:Aggression / Q000145:classification* / Q000187:drug effects / Q000523:psychology; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy / Q000523:psychology*; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D018967:Risperidone / Q000627:therapeutic use; D016728:Self-Injurious Behavior / Q000145:classification / Q000188:drug therapy / Q000523:psychology; D012720:Severity of Illness Index
D014150:Antipsychotic Agents; D018967:Risperidone
Aggression; Autism; Disruptive behavior; Self-injury