Proline-catalyzed asymmetric synthesis of syn- and anti-1,3-diamines.
A general organocatalytic strategy for asymmetric synthesis of both syn/anti-1,3-diamines has been developed. The strategy employs proline-catalyzed sequential α-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes as the key step where syn-1,3-diamine was obtained as the most favorable product.
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL) , Homi Bhabha Road, Pune 411008, Maharashtra, India.
Pradeep
P
Kumar
Vishwajeet
V
Jha
Rajesh
R
Gonnade
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D003959:Diamines; D011392:Proline