An EEG Finger-Print of fMRI deep regional activation.
This work introduces a general framework for producing an EEG Finger-Print (EFP) which can be used to predict specific brain activity as measured by fMRI at a given deep region. This new approach allows for improved EEG spatial resolution based on simultaneous fMRI activity measurements. Advanced signal processing and machine learning methods were applied on EEG data acquired simultaneously with fMRI during relaxation training guided by on-line continuous feedback on changing alpha/theta EEG measure. We focused on demonstrating improved EEG prediction of activation in sub-cortical regions such as the amygdala. Our analysis shows that a ridge regression model that is based on time/frequency representation of EEG data from a single electrode, can predict the amygdala related activity significantly better than a traditional theta/alpha activity sampled from the best electrode and about 1/3 of the times, significantly better than a linear combination of frequencies with a pre-defined delay. The far-reaching goal of our approach is to be able to reduce the need for fMRI scanning for probing specific sub-cortical regions such as the amygdala as the basis for brain-training procedures. On the other hand, activity in those regions can be characterized with higher temporal resolution than is obtained by fMRI alone thus revealing additional information about their processing mode.
The Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: yehudit.hasson@gmail.com.
Yehudit
Y
Meir-Hasson
Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Israel.
Sivan
S
Kinreich
Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Israel.
Ilana
I
Podlipsky
Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel; School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Talma
T
Hendler
The Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Nathan
N
Intrator
D000679:Amygdala / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D014793:Visual Cortex / Q000502:physiology
EEG Finger-Print; Ridge-regression; Simultaneous fMRI/EEG; Time/frequency