[Search for new drugs with antiarrhythmic properties among derivatives of adamant-2-ylamides of alkylamidocarbonic acids].
The experiments on white outbred awaken male rats have shown that derivatives of adamant-2-ylamides of alkylamidocarbonic acids exhibit prominent antiarrhythmic (antifibrillatory) effect on the model of calcium chloride arrhythmia. The most pronounced effect was demonstrated by N-[2(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide. This compound was also active on the model of aconitine arrhythmia, which is characteristic of class-I antiarrhythmic agents. It is established that N-[2-(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide has prominent antiarrhythmic activity and is more safe than other antiarrhythmic drugs of class I (lidocaine, ethmosine, novocainamide), class IV (verapamil), and class III (cardiocyclide).
A I
AI
Turilova
N I
NI
Avdiutina
B M
BM
Piatin
L N
LN
Grushevskaia
T S
TS
Gan'shina
R S
RS
Mirzoian
D000157:Aconitine / Q000009:adverse effects / Q000494:pharmacology; D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051381:Rats; D061585:Voltage-Gated Sodium Channel Agonists / Q000009:adverse effects / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D001549:Benzamides; C585026:N-(2(adamant-2-yl)aminocarbonylmethyl)-N'-(3-(diethylamino)propyl)-4-nitrobenzamide; D061585:Voltage-Gated Sodium Channel Agonists; D000218:Adamantane; D000157:Aconitine