Peritoneal fluid transport: mechanisms, pathways, methods of assessment.
Fluid removal during peritoneal dialysis is controlled by many mutually dependent factors and therefore its analysis is more complex than that of the removal of small solutes used as markers of dialysis adequacy. Many new tests have been proposed to assess quantitatively different components of fluid transport (transcapillary ultrafiltration, peritoneal absorption, free water, etc.) and to estimate the factors that influence the rate of fluid transport (osmotic conductance). These tests provide detailed information about indices and parameters that describe fluid transport, especially those concerning the problem of the permanent loss of ultrafiltration capacity (ultrafiltration failure). Different theories and respective mathematical models of mechanisms and pathways of fluid transport are presently discussed and applied, and some fluid transport issues are still debated.
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland. Electronic address: jwaniewski@ibib.waw.pl.
Jacek
J
Waniewski
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D008954:Models, Biological; D010530:Peritoneal Dialysis / Q000379:methods; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D010537:Peritoneum / Q000378:metabolism* / Q000502:physiology; D016032:Randomized Controlled Trials as Topic / Q000639:trends; D015398:Signal Transduction / Q000502:physiology; D014018:Tissue Distribution / Q000502:physiology; D014462:Ultrafiltration / Q000379:methods
Free water transport; Osmotic conductance; Peritoneal absorption; Spatially distributed model; Three pore model