Effect of platelet-rich plasma on fibrocartilage, cartilage, and bone repair in temporomandibular joint.
OBJECTIVE
The purpose of the present study was to explore the potential use of platelet-rich-plasma (PRP) in the treatment of temporomandibular joint osteoarthritis (TMJ-OA).


METHODS
Surgical defects were created bilaterally on the condylar fibrocartilage, hyaline cartilage, and bone to induce an osteoarthritic TMJ in rabbits. PRP was applied to the right joints of the rabbits (PRP group), and the left joints received physiologic saline (control group). After 4 weeks, the rabbits were sacrificed for histologic and scanning electron microscopy (SEM) examinations. The data were analyzed statistically.


RESULTS
The new bone regeneration was significantly greater in the PRP group (P < .011). Although the regeneration of the fibrocartilage and hyaline cartilage was greater in the PRP group, no statistically significant difference was found between the 2 groups. SEM showed better ultrastructural architecture of the collagen fibrils in the PRP group.


CONCLUSIONS
PRP might enhance the regeneration of bone in TMJ-OA.
Assistant Professor, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey. Electronic address: NCelebi@erciyes.edu.tr.
Nükhet
N
Kütük
Associate Professor, Department of Oral and Maxillofacial Surgery, Ondokuz Mayis University Faculty of Dentistry, Samsun, Turkey.
Burcu
B
Baş
Resident, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey.
Emrah
E
Soylu
Resident, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey.
Zeynep Burçin
ZB
Gönen
Resident, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey.
Canay
C
Yilmaz
Resident, Department of Histology, Erciyes University Faculty of Medicine, Melikgazi, Kayseri, Turkey.
Esra
E
Balcioğlu
Professor, Department of Histology, Erciyes University Faculty of Medicine, Melikgazi, Kayseri, Turkey.
Saim
S
Özdamar
Professor, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey.
Alper
A
Alkan
D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones / Q000601:surgery; D002356:Cartilage / Q000601:surgery; D003094:Collagen / Q000648:ultrastructure; D051445:Fibrocartilage / Q000601:surgery; D008335:Mandibular Condyle / Q000601:surgery*; D010003:Osteoarthritis / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011817:Rabbits; D013704:Temporomandibular Joint / Q000601:surgery*; D019224:Temporomandibular Joint Disc / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000601:surgery*
D003094:Collagen