Apocrine adenocarcinoma of the eyelid: case series and review.
OBJECTIVE
To report 2 patients with apocrine adenocarcinoma of the eyelid and review the literature.


METHODS
Noncomparative, retrospective case series and review.


METHODS
Clinical data of 2 patients with histopathologic diagnoses of apocrine adenocarcinoma of the eyelid were obtained from medical records. The histopathology and immunohistochemistry data for the 2 cases were studied. A retrospective review was performed on all reported cases of eyelid apocrine carcinoma.


METHODS
Clinical features, histopathology, immunohistochemistry, and clinical course following treatment are reported. The results of a retrospective review of clinical presentations, local and systemic spread, treatment method, and prognosis from published case reports on eyelid apocrine adenocarcinoma are discussed.


RESULTS
One patient had orbital invasion at presentation. This patient had radiotherapy alone and had no systemic or local recurrence at 2 years. One patient underwent a 4-mm margin wide surgical excision. This patient had no local or systemic recurrences at 1 year. A review of the literature suggests that the prognosis of adnexal apocrine tumors is indeterminate and variable. Most patients have successful outcomes following local surgical excision. Radiotherapy has been used as an adjunctive treatment for local metastatic disease.


CONCLUSIONS
Apocrine adenocarcinoma is a rare adnexal tumor of the eyelid, which may present with orbital invasion.
*South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia; †Department of Ophthalmology, Sydney Hospital and Sydney Eye Hospital, Sydney, New South Wales, Australia; ‡Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; and §The Royal Victorian Eye and Ear Hospital, Orbital Plastics and Lacrimal Unit, Melbourne, Australia.
Edwin C
EC
Figueira
Jenny
J
Danks
Akihide
A
Watanabe
Jwu Jin
JJ
Khong
Lorraine
L
Ong
Dinesh
D
Selva
D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D000369:Aged, 80 and over; D001050:Apocrine Glands / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000628:therapy