Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics, Incheon 400-103.
Bora
B
Kim
Jee-Young
JY
Lee
Ha-Yeon
HY
Lee
Ky-Youb
KY
Nam
Jongil
J
Park
Su Min
SM
Lee
Jin Eun
JE
Kim
Joo Dong
JD
Lee
Jae Sung
JS
Hwang
Hesperidin; Melanophilin; Melanosome transport; Pigmented reconstructed epidermis model; Rab27A