Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice.
Gallic acid, a phenolic phytochemical, has been shown to exert a variety of effects, including anti-oxidative, anti- carcinogenic, anti-allergic, and anti-inflammatory effects. In this study, we attempted to determine whether gallic acid affects metabolic syndrome such as obesity and diabetes. Diet-induced obesity mice were treated intraperitoneally once per day with gallic acid (10 mg/kg/day). After 2 weeks of treatment, the mice were sacrificed to collect the blood for metabolic parameter assessments, and the adipose tissues and liver to weigh and analyze. The triglyceride concentrations were significantly improved in the gallic acid group relative to those measured in the control group. And most importantly, the blood glucose concentrations in the gallic acid group were significantly improved. In the epididymal white adipose tissue of the gallic acid group, adipocyte size was reduced, PPARγ expression was induced, and the Akt signaling pathway was activated. Our results demonstrate that gallic acid improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity. The findings of an upregulation of PPARγ expression and Akt activation also contribute to our current understanding of the mechanisms underlying the effects of gallic acid on glucose metabolism.
Oral Cancer Research Institute.
Eun-Jung
EJ
Bak
Jinmoon
J
Kim
Sungil
S
Jang
Gye-Hyeong
GH
Woo
Ho-Geun
HG
Yoon
Yun-Jung
YJ
Yoo
Jeong-Heon
JH
Cha
D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight; D004435:Eating / Q000187:drug effects; D005707:Gallic Acid / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D018149:Glucose Intolerance / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D047495:PPAR gamma / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D047495:PPAR gamma; D014280:Triglycerides; D005707:Gallic Acid; D051057:Proto-Oncogene Proteins c-akt