One-pot synthesis of functionalized 2,5-dihydrofurans via an amine-promoted Petasis borono-Mannich reaction.
A series of functionalized 2,5-dihydrofurans were efficiently synthesized via an amine-promoted Petasis borono-Mannich reaction of 4-substituted 1,2-oxaborol-2(5H)-ols with salicylaldehydes in high yields. The process, which combines a boronic acid-based Mannich reaction and a highly efficient intramolecular SN2 cyclization, provides a one-step and efficient route toward 2,5-dihydrofurans from simple and stable starting materials.
Key Lab for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China , and Shanghai Institute of Organic Chemistry, Chinese Academy of Science , 345 Lingling Road, Shanghai 200032, China.
Chun-Xiao
CX
Cui
Hui
H
Li
Xian-Jin
XJ
Yang
Jun
J
Yang
Xiao-Qiang
XQ
Li