Clinical analysis of five methods used to treat condylomata acuminata.
OBJECTIVE
Treatments for condylomata acuminata (CA) include pharmacotherapy and surgical therapies, but each treatment has its limitations. The aim of this study was to investigate the virus clearance rate, wart cure rate and safety of 5 methods on CA.


METHODS
361 patients diagnosed with CA were divided into groups A (<0.5 cm), B (0.5-2.0 cm) and C (>2.0-4.0 cm) according to the maximum diameter of their lesion. Five treatments were compared in each group, and the clinical outcomes were evaluated during follow-ups.


RESULTS
A 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is preferred if the maximum lesion diameter is <0.5 cm and an ALA-PDT plus cryotherapy treatment is preferred for lesions 0.5-2.0 cm. For lesions >2.0- 4.0 cm, an ALA-PDT retreatment (after cryotherapy or CO2 laser treatment) should be the first choice.


CONCLUSIONS
The treatments for CA should be chosen according to the maximum diameter of each patient's lesion.
Department of Dermatovenereology, Ningxia Medical University General Hospital, Yinchuan, China.
Huijuan
H
Shi
Xiaoming
X
Zhang
Chunmei
C
Ma
Nan
N
Yu
Jingxia
J
Wang
Li
L
Xia
Xinhong
X
Ge
Min
M
Liu
Aixia
A
Duan
D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000145:classification*; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D003452:Cryosurgery / Q000009:adverse effects; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects; D017319:Photosensitizing Agents / Q000627:therapeutic use; D019233:Retreatment; D019562:Viral Load; D055815:Young Adult
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid