Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats.
This study investigated effect of extract containing quercetin-3-O-β-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.
Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Se Eun
SE
Lee
Hyun Ju
HJ
Song
Sun Young
SY
Park
Yoonjin
Y
Nam
Chang Ho
CH
Min
Do Yeon
DY
Lee
Jun Yeong
JY
Jeong
Hyun Su
HS
Ha
Hyun-Jung
HJ
Kim
Wan Kyun
WK
Whang
Ji Hoon
JH
Jeong
In Kyeom
IK
Kim
Hak Rim
HR
Kim
Young Sil
YS
Min
Uy Dong
UD
Sohn
Chronic gastritis; Iodoacetamide; QGC; Reactive oxygen species; Superoxide dismutase