β-chain extension: a new mode of carbon-carbon bond formation and chain extension by polyketide synthases.
The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
Leibniz Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, 30167 Hannover (Germany); University of Bristol, School of Chemistry, Cantock's Close, Bristol, BS8 1TS (UK). russell.cox@oci.uni-hannover.de, r.j.cox@bris.ac.uk.
Russell J
RJ
Cox
D055162:Biocatalysis; D019117:Burkholderia / Q000201:enzymology / Q000378:metabolism; D002244:Carbon / Q000737:chemistry*; D020134:Catalytic Domain; D007783:Lactones / Q000737:chemistry / Q000378:metabolism; D018942:Macrolides / Q000378:metabolism*; D048630:Polyketide Synthases / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary
D007783:Lactones; D018942:Macrolides; D002244:Carbon; D048630:Polyketide Synthases; C041443:rhizoxin
biosynthesis; branching; polyketides; rhizoxin