Validation of near infrared spectroscopy to measure abdominal somatic tissue oxygen saturation in neonates.
OBJECTIVE
In this study, we validated the use of the FORE-SIGHT® (CAS Medical Systems, Branford, CT USA) tissue oximeter monitor on abdominal tissue oxygenation in infants ≤4 kg using a stool-interference compensation algorithm.


METHODS
A total of 40 neonates with an umbilical venous catheter (UVC) were enrolled in this study. We measured abdominal tissue saturation (StO2) values using FORE-SIGHT, and compared to a Reference StO2 value derived from weighted co-oximetry values from the UVC and pulse oximeter measurements.


RESULTS
There was a strong correlation between NIRS calculated StO2 measurements when compared with the reference StO2, with an overall bias (sd) of -0.77 (5.06)% and a concordance correlation coefficient (CCC) of 0.789.


CONCLUSIONS
Data from this validation study suggest that the FORE-SIGHT monitor, which compensates for the optical properties of stools in neonates, can yield accurate measures of abdominal tissue oxygen saturation.
Children's National Medical Center and Department of Neonatology, The George Washington University School of Medicine, Washington, D.C., USA.
M M
MM
Said
N
N
Niforatos
K
K
Rais-Bahrami
D000005:Abdomen; D002405:Catheterization, Central Venous / Q000379:methods*; D005243:Feces; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008470:Meconium / Q000378:metabolism*; D008991:Monitoring, Physiologic / Q000379:methods; D010092:Oximetry; D010101:Oxygen Consumption / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D014471:Umbilical Veins
NEC; NIRS; meconium; mesenteric saturation