Paediatric-onset systemic lupus erythematosus.
Paediatric-onset systemic lupus erythematosus (SLE) is usually more severe than its adult counterpart. In particular, there is a higher incidence of renal and central nervous system involvement. Specific measures to assess disease activity and damage have been implemented. The disease is very rare before the fifth birthday and therefore the onset of an SLE picture in the first years of life should lead to the suspicion of the presence of one of the rare monogenic diseases that causes SLE or of one of those congenital diseases that has been showed to be closely associated with the SLE.
Department of Pediatrics, University of Genoa and Pediatria e Reumatologia, G. Gaslini Institute, Genoa, Italy. Electronic address: claramalattia@ospedale-gaslini.ge.it.
Clara
C
Malattia
Alberto
A
Martini
D000293:Adolescent; D017668:Age of Onset; D001323:Autoantibodies / Q000097:blood; D002648:Child; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008181:Lupus Nephritis / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000188:drug therapy / Q000276:immunology
D001323:Autoantibodies
Juvenile SLE; Monogenic SLE; Paediatric-onset SLE; SLE-associated genetic diseases