Early initiation of enteral nutrition improves outcomes in burn disease.
BACKGROUND
Burned patients have increased level of mortality, possibly due to late introduction of enteral feeding. The aim of this study was to compare the benefits and safety of very early enteral nutrition introduction compared to the normal diet among burns patients in an intensive care unit.


METHODS
Participants consisted of 101 patients, aged 20-76 years (mean age 48 years), 49 men and 52 women, with burns that covered more than 20% of the body. The intervention group consisted of 52 subjects fed via introduced nasojejunal probe that started within four hours after admission to the hospital. The control group consisted of fifty patients fed in standard manner per os (three standard hospital meals) immediately after the first wound dressing.


RESULTS
The average decline BMI in control group was 2.27±0.56 kg/m2, while the average reduction in BMI in the intervention group was 1.77±0.38 kg/m2 (p<0.001). The largest drop of albumin concentration in the control group was 28.5%, whereas in the intervention group was 23.8%. (p<0.001). The greatest decrease of transferrin concentration in the control group was 31.1%, while the average reduction in the intervention group was 18.3%. (p<0.001). C-reactive protein values were statistically higher in control group (p<0.001). Intervention group had lower rate of complications and infection rates.


CONCLUSIONS
Enteral nutrition in burned patients should begin within few hours of burn onset. Such approach leads to better outcomes, reduces complications, and improves nutritional profile.
Department of Internal Medicine, Intensive Care Unit, University Hospital Split and School of Medicine in Split, Soltanska 1, 21000 Split, Croatia. vedkovac@inet.hr.
Vesna Kovacic
VK
Vicic
Maja
M
Radman
Vedran
V
Kovacic
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002056:Burns / Q000097:blood / Q000150:complications / Q000628:therapy*; D002097:C-Reactive Protein / Q000032:analysis; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors; D014168:Transferrin / Q000032:analysis
D012709:Serum Albumin; D014168:Transferrin; D002097:C-Reactive Protein