[Effect of a complex preparation of sea urchin shells on blood glucose level and oxidative stress parameters in type II diabetes model].
The experimental preclinical study on mice showed that a complex of polyhydroxylated naphthoquinone pigments and minerals from shells of sea urchins decreases the concentration of glucose, stimulates the synthesis of phospholipids in liver, and has antioxidant properties. On the model of streptozotocin-nicotinamide-induced type II diabetes, this complex of polyhydroxylated naphthoquinone pigments and minerals from sea urchin shells exhibited activity after administration for 10 days in a dose of 1.8 mg/kg.
M A
MA
Kovaleva
S A
SA
Ivanova
M N
MN
Makarova
O N
ON
Pozharitskaia
A N
AN
Shikov
V G
VG
Makarov
D000825:Animal Structures / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D010860:Pigments, Biological / Q000737:chemistry / Q000494:pharmacology*; D012617:Sea Urchins / Q000737:chemistry*; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010860:Pigments, Biological