Obesity, inflammation and diet.
Obesity is a state in which there is an over-accumulation of subcutaneous and/or abdominal adipose tissue. This adipose tissue is no longer considered inert and mainly devoted to storing energy; it is emerging as an active tissue in the regulation of physiological and pathological processes, including immunity and inflammation. Adipose tissue produces and releases a variety of adipokines (leptin, adiponectin, resistin, and visfatin), as well as pro- and anti-inflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-4, IL-6, and others). Adipose tissue is also implicated in the development of chronic metabolic diseases such as type 2 diabetes mellitus or cardiovascular disease. Obesity is thus an underlying condition for inflammatory and metabolic diseases. Diet or dietary patterns play critical roles in obesity and other pathophysiological conditions. A healthy diet and some nutrients are generally considered beneficial; however, some dietary nutrients are still considered controversial. In this article, dietary factors that influence inflammation associated with obesity are discussed.
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Korea. ; Research Institute of Medical Nutrition, Kyung Hee University, Seoul, Korea.
Hansongyi
H
Lee
In Seok
IS
Lee
Ryowon
R
Choue
Adipose tissue; Clinical trial; Diet; Epidemiology; Inflammation; Obesity