Effect of Korean Red Ginseng on radiation-induced bone loss in C3H/HeN mice.
This study investigated the effects of Korean Red Ginseng (KRG) on radiation-induced bone loss in C3H/HeN mice. C3H/HeN mice were divided into sham and irradiation (3 Gy, gamma-ray) groups. The irradiated mice were treated for 12 wk with vehicle, KRG (per os, p.o.) or KRG (intraperitoneal). Serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase, estradiol level, and biomechanical properties were measured. Tibiae were analyzed using micro-computed tomography. Treatment of KRG (p.o., 250 mg/kg of body weight/d) significantly preserved trabecular bone volume, trabecular number, structure model index, and bone mineral density of proximal tibia metaphysic, but did not alter the uterus weight of the mice. Serum ALP level was slightly reduced by KRG treatment. However, grip strength, mechanical property, and cortical bone architecture did not differ among the experimental groups. The results indicate that KRG can prevent radiation-induced bone loss in mice.
General Toxicity Team, Korea Testing & Research Institute, Seoul 150-038, Korea.
Jin-Hee
JH
Lee
Hae-June
HJ
Lee
Miyoung
M
Yang
Changjong
C
Moon
Jong-Choon
JC
Kim
Chun-Sik
CS
Bae
Sung-Kee
SK
Jo
Jong-Sik
JS
Jang
Sung-Ho
SH
Kim
Bone loss; Korean Red Ginseng; Panax ginseng; Radiation; Trabecular bone