[Association research between polymorphism of IFN-gamma and IL-10, environmental risk factors, and susceptibility to esophageal cancer].
OBJECTIVE
To explore the polymorphism of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) with susceptibility to esophageal cancer (EC), as well as the interaction between the environmental risk factors and the polymorphism of IFN-gamma or IL- 10. To explore the interaction between the polymorphism of IFN-gamma and IL-10.


METHODS
According to the case-control design, 120 EC cases and 122 controls were examined. PCR technology was used to determine the genotypes of IFN-gamma + A874T and IL-10 -A1082G. Indicators of quantitative analysis for interaction between IFN-gamma and IL-10, and parts of environmental factors were calculated by crossover analysis multiplicative mode.


RESULTS
Allele frequencies of T of IFN-gamma + A874T was 37.92% in case group higher than 28.7% in control group (chi2 = 4.6414, P = 0.0312). Compared with IFN-gamma + 874AA genotype, OR of IFN-gamma + 874AT genotype was 1.729 (95% CI 1.015-2.947), OR of IFN-gamma + 874TT genotype was 2.923 (95% CI 1.227-5.214) and OR of IFN-gamma + 874AT + TT genotype was 1.821 (95% CI 1.081-3.069). There was synergistic action between IFN-gamma + 874AT + TT and drink index, moldy food and regular diet habit, their S respectively were 1.909, 4.154 and 5.026. The interaction between IFN-gamma + 874AT + TT and IL-10 -1082AG + GG was not increased the risk of EC OR = 2.342 (95% CI 0.975-5.626).


CONCLUSIONS
The IFN-gamma + 874AT genotype might be a risk factor to EC. T allele gene may be heredity predisposing gene of EC. IFN-gamma + 874 AT + TT genotype as the corresponding reduction of the environmental risk factors can reduce the incidence of esophageal cancer.
Department of Center for Disease Prevention and Control of Tai'an City, Tai'an 271000,China. duweiping1980@163.com
Weiping
W
Du
Wenjing
W
Ye
Minghui
M
Chen
Dong
D
Li
Xuean
X
Jing
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D004777:Environment; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C573415:IFNG protein, human; C508609:IL10 protein, human; D016753:Interleukin-10; D007371:Interferon-gamma