The cross-dehydrogenative coupling of C(sp3)-H bonds: a versatile strategy for C-C bond formations.
Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of CC bonds by directly connecting two different CH bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both CH bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.
Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca.
Simon A
SA
Girard
Thomas
T
Knauber
Chao-Jun
CJ
Li
CC coupling; CH activation; cross-coupling; green chemistry; synthetic methods