The feasibility and efficacy of stereotactic body radiotherapy for centrally-located lung tumors.
OBJECTIVE
To investigate the toxicity and outcome of stereotactic body radiotherapy (SBRT) for centrally-located lung tumors.


METHODS
A retrospective review was conducted in 45 consecutive patients with centrally-located lung tumors who underwent SBRT. The incidence rate of adverse events (AEs) and outcome after SBRT for primary (32 patients), metastatic and recurrent (13 patients) lung tumors were evaluated.


RESULTS
The median follow-up period was 21.2 months. Except for one patient who had grade 4 gastrointestinal toxicity, no patient exhibited any grade 4-5 AE. The 2-year overall survival of patients with primary non-small cell lung cancer (NSCLC) was significantly better than that of those with metastatic and recurrent tumors of 69.4% vs. 46.9% (p=0.04). The local control rates at two years, for patients in the NSCLC and the metastatic/recurrent groups were 70.9% and 100%, respectively (p=0.98).


CONCLUSIONS
SBRT provided effective treatment for centrally-located lung tumors with tolerable toxicity.
Department of Radiology, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan. yamachan07291973@yahoo.co.jp.
Wataru
W
Takahashi
Hideomi
H
Yamashita
Mami
M
Omori
Mayuka
M
Kitaguchi
Shino
S
Shibata-Kobayashi
Akira
A
Sakumi
Keiichi
K
Nakagawa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D016634:Radiosurgery; D012189:Retrospective Studies; D015996:Survival Rate
Centrally-located lung tumor; SBRT; adverse effect; local control; lung cancer