Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular Friedel-Crafts type allylic alkylation reactions.
A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel-Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity and enantioselectivity, mild reaction conditions, and an easily accessed chiral ligand.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
Qing-Long
QL
Xu
Chun-Xiang
CX
Zhuo
Li-Xin
LX
Dai
Shu-Li
SL
You
D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism
D000498:Allyl Compounds; D002243:Carbolines; D002254:Carbonates; D007211:Indoles; D008024:Ligands; D007495:Iridium