[Oxidative stress and susceptibility of periodontal disease].
OBJECTIVE
To investigate the relationship between dietary antioxidant status and susceptibility of periodontal disease in humans.


METHODS
Fifty patients with moderate-to-sever periodontal disease and 50 subjects without periodontal disease were enrolled in this study. Food frequency questionnaire and 72-hour diet recall were conducted to study the dietary pattern and antioxidant nutrients intake in patients and healthy subjects. Nutritional status including vitamins, mineral substance, and antioxidant enzymes in these 2 groups were analyzed in serum and saliva samples by liquid chromatography-mass spectrometry (LC-MS). SPSS 19.0 software package was used for paired t test.


RESULTS
Compared with the control group, the chronic periodontal group had lower levels of potatoes, aquatic product, milk, soy, fresh vegetables, fruit and vitamin supplements intake(P<0.05). Through food components analysis we found that the intake of vitamin A, C, B2, E, calcium, magnesium, copper, selenium was significantly lower in the chronic periodontal disease group than that in the control group (P<0.05). Biochemical analysis demonstrated that antioxidant nutrient levels including antioxidant enzyme SOD in serum and saliva together with magnesium, calcium, manganese, zinc in saliva were significantly lower in disease periodontal group than in the control group (P<0.05).


CONCLUSIONS
Oxidative stress plays an essential role in the occurrence and development of periodontal disease. The antioxidant nutrients may help to protect paradentium. Supported by Research Fund from Shanghai Municipal Health Bureau (20114103).
Department of Clinical Nutrition, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;China.E-mail:zhangmf3176@126.com.
Mei-fang
MF
Zhang
Yi-jing
YJ
Huang
Hai-feng
HF
Zhang
Wen
W
Tang
Jie
J
Zhou
D000975:Antioxidants; D004032:Diet; D006801:Humans; D008903:Minerals; D018384:Oxidative Stress; D010510:Periodontal Diseases; D014815:Vitamins
D000975:Antioxidants; D008903:Minerals; D014815:Vitamins