Mixed lanthanide oxide nanoparticles as dual imaging agent in biomedicine.
There is no doubt that the molecular imaging is an extremely important technique in diagnosing diseases. Dual imaging is emerging as a step forward in molecular imaging technique because it can provide us with more information useful for diagnosing diseases than single imaging. Therefore, diverse dual imaging modalities should be developed. Molecular imaging generally relies on imaging agents. Mixed lanthanide oxide nanoparticles could be valuable materials for dual magnetic resonance imaging (MRI)-fluorescent imaging (FI) because they have both excellent and diverse magnetic and fluorescent properties useful for dual MRI-FI, depending on lanthanide ions used. Since they are mixed nanoparticles, they are compact, robust, and stable, which is extremely useful for biomedical applications. They can be also easily synthesized with facile composition control. In this study, we explored three systems of ultrasmall mixed lanthanide (Dy/Eu, Ho/Eu, and Ho/Tb) oxide nanoparticles to demonstrate their usefulness as dual T2 MRI-FI agents.
Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
Wenlong
W
Xu
Badrul Alam
BA
Bony
Cho Rong
CR
Kim
Jong Su
JS
Baeck
Yongmin
Y
Chang
Ji Eun
JE
Bae
Kwon Seok
KS
Chae
Tae Jeong
TJ
Kim
Gang Ho
GH
Lee
D000818:Animals; D020811:Biomedical Technology / Q000379:methods; D002460:Cell Line; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes; D006801:Humans; D028581:Lanthanoid Series Elements; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles; D010087:Oxides
D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D010087:Oxides