[Potential cytostatic effect of the maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1-H-pyrrol-2,5-dione].
The cytostatic/cytotoxic effects of the maleimide derivative 1-(4-Cl-Benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) have been estimated on epithelial derived human cell cultures (Colo 205, MCF-7, and Hela). The anticancer and toxic effects of MI-1 have been investigated on DMH-induced cancer development and normal colon morphology in rats. The results showed that the compound studied has low cytotoxicity but produces a strong antiproliferative effect on cell cultures and partially suppresses colon cancer development in DMH-induced model. The MI-1 effect on normal colon mucosa is insignificant, and no destructive changes have been detected in the intestine of rats. This maleimide derivate can be considered as a promising anticancer drug.
L V
LV
Garmanchuk
O V
OV
Linchak
E O
EO
Denis
V V
VV
Nikulina
O I
OI
Dzhus
N N
NN
Khranovskaia
T V
TV
Nikolaenko
E N
EN
Babuta
V K
VK
Rybal'chenko
D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D004111:Dimenhydrinate / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008041:Linoleic Acids / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008301:Maleimides / Q000737:chemistry / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D003603:Cytotoxins; D008041:Linoleic Acids; D008301:Maleimides; D053284:Polyunsaturated Alkamides; D011758:Pyrroles; D004111:Dimenhydrinate; C001757:N-(2-methylbenzyl)linoleamide