[Low dose vasopressin is effective for catecholamine-resistant hypotension after resection of pheochromocytoma].
The perioperative management of pheochromocytoma is challenging for anesthesiologists and persistent hypotension secondary to cathecholamine depletion after tumor resection can be refractory to treatment. A 64-year-old man underwent right adrenalectomy for treatment of massive pheochromocytoma. Doxazosin administration was started and increased gradually to 12 mg daily. He was premedicated with doxazosin on the day of the surgery. Induction was uneventful but there was a sudden increase of blood pressure with tachycardia on handling of tumor which was controlled by intravenous remifentanil, landiolol, diltiazem, and magnesium sulfate. With dissection of the tumor, the blood pressure dropped to 65/40 mmHg, which was resistant to fluid and cathecholamine treatment. After commencement of low dose vasopressin administration (two boluses of 0.08 U followed by 1.6 U x hr(-1)), blood pressure gradually recovered to normal ranges. Low dose vasopressin can be safely used to treat postadrenalectomy hypotension and also can reduce the cathecholamine dose.
Department of Anesthesiology and Critical Care Medicine, Kobe City Medical Center General Hospital, Kobe 650-0047.
Shinya
S
Kanazawa
Naoko
N
Uehara
Hideya
H
Seo
Ikuko
I
Miyawaki
Kazuo
K
Yamazaki
D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000315:Adrenalectomy; D002395:Catecholamines; D004351:Drug Resistance; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000601:surgery*; D011183:Postoperative Complications; D014667:Vasopressins / Q000008:administration & dosage*
D002395:Catecholamines; D014667:Vasopressins