Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema.
OBJECTIVE
To investigate if cases of diabetic macular oedema (DMO) associated with serous macular detachment (SMD) have a different topographic profile of retinal thickening compared with DMO cases not associated with SMD.


METHODS
Optical coherence tomography scans of 152 eyes from 152 patients with centre-involving DMO and central subfield thickness >350 µm were identified. Measurements were taken of the neural retina at the highest point of thickening within the central subfield (H) and lateral extent of retina thicker than 350 µm (W). Group means were compared between eyes with SMD and eyes without SMD.


RESULTS
SMD was present in 55 eyes (36%). H was lower in eyes with SMD than in eyes without SMD (396 µm vs 550 µm, p<0.001) while W was higher in eyes with SMD compared with eyes without SMD (4.74 mm vs 4.18 mm, p=0.011).


CONCLUSIONS
There were distinct differences in topographical profiles of retinal thickening between eyes with SMD and eyes without SMD. These findings suggest a possible mechanical basis for the pathogenesis of SMD in DMO.
Royal Wolverhampton Hospitals NHS Trust, , Wolverhampton, UK.
Hannah
H
Shereef
Oliver
O
Comyn
Sobha
S
Sivaprasad
Philip
P
Hykin
Gemmy
G
Cheung
Nirodhini
N
Narendran
Yit Chiun
YC
Yang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008269:Macular Edema / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
Imaging; Macula; Retina