The biology of APOL1 with insights into the association  between APOL1 variants and chronic kidney disease.
Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1-associated kidney disease.
Sethu M
SM
Madhavan
John F
JF
O'Toole
D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000097:blood / Q000235:genetics*; D044383:Black People / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051436:Renal Insufficiency, Chronic / Q000235:genetics*; D014347:Trypanosoma brucei gambiense; D014353:Trypanosomiasis, African / Q000235:genetics
C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL