Mouse models in bone marrow transplantation and adoptive cellular therapy.
Mouse models of transplantation have been indispensable to the development of bone marrow transplantation (BMT). Their role in the generation of basic science knowledge is invaluable and is subject to discussion below. However, this article focuses on the direct role and relevance of mouse models towards the clinical development and advances in BMT and adoptive T-cell therapy for human diseases. The authors aim to present a thoughtful perspective on the pros and cons of mouse models while noting that despite imperfections these models are obligatory for the development of science-based medicine.
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX.
Caroline
C
Arber
Malcolm K
MK
Brenner
Pavan
P
Reddy
D000222:Adaptation, Physiological; D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D051379:Mice