[Study on transdermal characteristics of compound Nanxing pain-relieving cataplasm and effects of gaultherolin in prescriptions].
OBJECTIVE
To study transdermal absorption characteristics of eugenol in compound Nanxing pain-relieving cataplasm, and discuss the effect of gaultherolin on the transdermal absorption of the cataplasm.


METHODS
The improved franz diffusing cell was adopted with hairless mice skins as transdermal carriers. The content of eugenol in receptor liquid, skins and cataplasm were analyzed by HPLC and compared with the cataplasm without gaultherolin.


RESULTS
The penetration rates of eugenol of cataplasms with and without gaultherolin were 13.18 and 9.58 microg x cm(-2) x h(-1), with the retention amount in skins of (185.02 +/- 19.23) and (160.23 +/- 16.54) microg x g(-1) and the retention amount in cataplasms was (1.96 +/- 0.12) and (1.71 +/- 0.15) mg, respectively.


CONCLUSIONS
Eugenol in compound Nanxing pain-relieving cataplasm has good pereutaoeous permeation. Gaultherolin in the cataplasm prescription can promote the absorption of eugenol.
Beijing University of Chinese Medicine, Beijing 100102, China. lysole@126.com
Ying
Y
Li
Shou-Ying
SY
Du
Yang
Y
Lu
Jie
J
Bai
Ying-Zi
YZ
Wang
Yue
Y
Wang
Yu-Shu
YS
Xing
Wei
W
Xiao
D000700:Analgesics / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D012459:Salicylates / Q000737:chemistry*; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013997:Time Factors
D000700:Analgesics; D004365:Drugs, Chinese Herbal; D012459:Salicylates; C585598:nanxing; C033069:methyl salicylate