Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis.
Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. The adipokines, which are cytokines secreted by adipose tissue, are key links between obesity and related diseases such as metabolic syndrome and atherosclerosis. LCN2 and A-FABP, both of which are major adipokines predominantly produced in adipose tissue, have recently been shown to be pivotal modulators of vascular function. However, different adipokines modulate the development of atherosclerosis in distinctive manners, which are partly attributable to their unique regulatory mechanisms and functions. This review highlights recent advances in the understanding of the role of two adipokines in mediating chronic inflammation and the pathogenesis of atherosclerosis.
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, China; Department of Medicine, Medical School of Soochow University, Suzhou, China.
Guangyu
G
Wu
Huating
H
Li
Mi
M
Zhou
Qichen
Q
Fang
Yuqian
Y
Bao
Aimin
A
Xu
Weiping
W
Jia
D000209:Acute-Phase Proteins / Q000378:metabolism*; D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000503:physiopathology; D019317:Evidence-Based Medicine; D050556:Fatty Acid-Binding Proteins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000378:metabolism*
D000209:Acute-Phase Proteins; D054392:Adipokines; D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins
adipocyte fatty acid-binding protein; atherosclerosis; lipocalin-2; obesity