Increased incidence of neonatal respiratory distress in infants with mucopolysaccharidosis type II (MPS II, Hunter syndrome).
Records were reviewed on all patients with mucopolysaccharidosis type II (Hunter syndrome) seen at a single institution from 1999 to 2013 to identify those with a history of neonatal intensive care. Eleven of 34 patients were in a neonatal intensive care unit and all had respiratory distress with 8 diagnoses of respiratory distress syndrome and 3 of transient tachypnea of the newborn. None of the infants were premature; four were delivered by cesarean section. These findings suggest that respiratory distress is more commonly observed in neonates with MPS II than in the general population. This may reflect airway disease already present in this disorder at the time of birth.
Division of Genetics, Birth Defects and Metabolism, Ann and Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Chicago, IL 60611, USA.
Charlotte
C
Dodsworth
Division of Genetics, Birth Defects and Metabolism, Ann and Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Chicago, IL 60611, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, USA. Electronic address: bburton@luriechildrens.org.
Barbara K
BK
Burton
D002585:Cesarean Section; D002641:Chicago / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D016532:Mucopolysaccharidosis II / Q000453:epidemiology / Q000503:physiopathology*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000503:physiopathology*
Hunter syndrome; Mucopolysaccharidosis II; Neonate; Respiratory distress