CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.
OBJECTIVE
The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population.


METHODS
Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods.


RESULTS
We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease.


CONCLUSIONS
Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.
Department of Intensive Care Unit, West China Hospital, Sichuan University Chengdu, Sichuan Province, China.
Lijing
L
Deng
Haixia
H
Zhou
Jing
J
Yang
Jun
J
Xiao
Bo
B
Wang
Lan
L
Wang
Xuemei
X
Ou
Yulin
Y
Feng
D000368:Aged; D060908:CTLA-4 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005541:Forced Expiratory Volume; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D012307:Risk Factors; D014797:Vital Capacity
D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
CTLA-4; chronic obstructive pulmonary disease; polymorphisms