Development, characterization, and cellular adhesion of poly(L-lactic acid)/poly(caprolactone triol) membranes for potential application in bone tissue regeneration.
Poly(L-lactide)/poly(caprolactone triol) (PLLA/PCL-T) membranes were prepared by solution casting in 100/0, 90/10, and 70/30 (w/w) ratios. The membranes were analyzed by dynamic mechanical analysis, differential scanning calorimetry, and mechanical tests. The thermal analysis showed that the 90/10 and 70/30 preparations were partly miscible systems. The glass transition temperature (Tg ) of PLLA decreases as the PCL-T concentration increases, which implies that PCL-T has a plasticizer function. An in vitro study with osteoblastic cells isolated from the calvariae of rats was performed in all preparations. The results obtained in this study showed that the addition of PCL-T to the PLLA matrix modifies its mechanical, thermal, and biological properties. These blends could be useful for tissue engineering for bone applications.
Federal University of São Carlos, Sorocaba, Brazil.
Daniel V
DV
Mistura
André D
AD
Messias
Eliana A R
EA
Duek
Márcia A T
MA
Duarte
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D002478:Cells, Cultured; D019344:Lactic Acid / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology*; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D023822:Tissue Engineering; D044366:Transition Temperature
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D019344:Lactic Acid; C033616:poly(lactide)
Bone tissue regeneration; Poly(caprolactone triol); Poly(l-lactide)