A method for separating PEGylated Au nanoparticle ensembles as a function of grafting density and core size.
After ligand exchange with PEG, Au NPs with differently mixed surface functionalities co-exist in the as-synthesized sample. It is found that the poorly grafted nanoparticles can be simply removed using a chromatographic method, and the well grafted nanoparticles can be eluted as a function of the core size.
Department of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio, 44106 USA. burda@case.edu.
Feng
F
Lu
Tennyson L
TL
Doane
Jun-Jie
JJ
Zhu
Clemens
C
Burda
D060326:Chemistry Techniques, Synthetic; D002845:Chromatography; D006046:Gold / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*
D011092:Polyethylene Glycols; D006046:Gold