Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime.
Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone glyoxime (L(1)H2) or 4-ethoxybenzaldehyde thiosemicarbazone glyoxime (L(2)H2)) thiosemicarbazone units were synthesized and characterized using (1)H NMR, (13)C NMR, HMQC, MS, infrared and, UV-VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L(1)H2 and L(2)H2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions. The detection of H-bonding (O-H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L(1)H2, L(2)H2, and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L(1)H2, [Ni(L1H)2], [Cu(L1H)2], L2H2, [Ni(L2H)2] and [Cu(L2H)2] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
Adnan Menderes University, Faculty of Science and Art, Department of Chemistry, 09010 Aydin, Turkey. Electronic address: ibabahan@adu.edu.tr.
Ilknur
I
Babahan
Adnan Menderes University, Faculty of Science and Art, Department of Chemistry, 09010 Aydin, Turkey. Electronic address: feyduran@adu.edu.tr.
Fatih
F
Eyduran
Adnan Menderes University, Faculty of Science and Art, Department of Biology, 09010 Aydin, Turkey.
Esin Poyrazoglu
EP
Coban
Adnan Menderes University, Faculty of Science and Art, Department of Chemistry, 09010 Aydin, Turkey.
Nil
N
Orhan
Adnan Menderes University, Faculty of Science and Art, Department of Chemistry, 09010 Aydin, Turkey.
Didem
D
Kazar
Adnan Menderes University, Faculty of Science and Art, Department of Biology, 09010 Aydin, Turkey.
Halil
H
Biyik
D000042:Absorption; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009532:Nickel / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D019216:Metals, Heavy; D010091:Oximes; D012997:Solvents; D013882:Thiosemicarbazones; D003035:Cobalt; D003300:Copper; D009532:Nickel
Antimicrobial activity; IR and electronic spectra; Spectroscopy; Thiosemicarbazone; Transition metal complex; vic-Dioxime