Breast lesions in reduction mammaplasty specimens: a histopathological pattern in 534 patients.
BACKGROUND
The prevalence of breast lesions (benign, precancerous and cancer lesions) in reduction mammaplasty (RM) specimens has rarely been reported in Europe and never in the Swiss population.


METHODS
Personal and histopathological data from 534 female patients who underwent RM were reviewed.


RESULTS
Benign and/or malignant lesions were detected in 76.2% of all patients. Benign breast lesions associated with an increased risk of developing breast cancer represented 2.8% of all lesions. Breast cancer in situ was identified in 5 (0.9%) patients. Patient age and previous history of breast cancer were risk factors for incidental breast cancer.


CONCLUSIONS
The rate of incidental carcinoma in situ was higher for patients with breast cancer history. Probably due to preoperative breast cancer investigation, no occult invasive breast cancer was found in reduction mammary specimens. Therefore before RM, breast cancer evaluation should be considered for all patients, especially for those with breast cancer risk factors (e.g., patient age, personal history of breast cancer).
Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1211, Switzerland.
M
M
Tadler
Senology Unit, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1211, Switzerland.
G
G
Vlastos
Division of Clinical Pathology, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1206, Switzerland.
M-F
MF
Pelte
Division of Clinical Pathology, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1206, Switzerland.
J-C
JC
Tille
Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva CH-1205, Switzerland.
C
C
Bouchardy
Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva CH-1205, Switzerland.
M
M
Usel
Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1211, Switzerland.
B
B
Pittet-Cuénod
Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospitals of Geneva and Faculty of Medicine, Geneva CH-1211, Switzerland.
A
A
Modarressi
D000328:Adult; D001943:Breast Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D005060:Europe; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D009367:Neoplasm Staging