Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.
The protease of norovirus, an important human pathogen, is essential for the viral replication and, therefore, represents a potential drug target. A series of tripeptide-based inhibitors of the protease were designed, synthesized and tested, among which several potent inhibitors were identified with Kivalues as low as 75 nM. The structure-activity relationships of these inhibitors are discussed.
Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States.
Lisheng
L
Deng
Zana
Z
Muhaxhiri
Mary K
MK
Estes
Timothy
T
Palzkill
B V Venkataram
BV
Prasad
Yongcheng
Y
Song