Comparison of the outcome of conventional in vitro fertilization and intracytoplasmic sperm injection in moderate male infertility from ejaculate.
OBJECTIVE
To evaluate whether couples with moderate male infertility should be treated with conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).


METHODS
A total of 249 couples with moderate male infertility undergoing their first IVF/ICSI cycle were enrolled in the study. The couples were divided into two groups according to the results of semen analysis: moderate oligozoospermia (O group) and moderate oligoasthenozoospermia (OA group). Sibling oocytes were randomized into groups to be inseminated either by conventional IVF or ICSI. Fertilization rate, embryo quality, implantation rate, and clinical pregnancy rate were examined.


RESULTS
There was no difference in the fertilization, implantation, and pregnancy rates between conventional IVF and ICSI in either the O group or OA group (p > 0.05). Additionally, in the OA group, the good quality embryo rate was similar after IVF or ICSI (p > 0.05). However, in the O group, the good quality embryo rate was significantly higher after ICSI than after IVF (p < 0.05).


CONCLUSIONS
Couples with moderate oligozoospermia or moderate oligoasthenozoospermia did not influence the major indices of IVF. Because of the uncertainties concerning the safety of ICSI, couples with moderate oligozoospermia or moderate oligoasthenozoospermia need not be subjected to this procedure.
Reproductive Medicine Centre, The Affiliated Hospital of Hainan Medical College, Haikou, PR China.
Bao-Guo
BG
Xie
Yuan-Hua
YH
Huang
Wei-Jie
WJ
Zhu
Song
S
Jin
D000328:Adult; D053627:Asthenozoospermia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D002681:China; D004542:Ejaculation; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D018579:Patient Selection; D011247:Pregnancy; D018873:Pregnancy Rate; D018570:Risk Assessment; D012307:Risk Factors; D055101:Semen Analysis; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D016896:Treatment Outcome