[Long-term clinical and hematologic effects of non-surgical treatment on aggressive periodontitis].
OBJECTIVE
To investigate the long-term effects of non-surgical treatment on clinical and hematologic states of patients with generalized aggressive periodontitis (GAgP).


METHODS
Patients with GAgP (n = 25) and healthy controls (n = 28) were recruited. The clinical parameters, including probing depth (PD), bleeding index (BI), attachment loss (AL) were examined and recorded. Blood cell variables, including white blood cells (WBC), leukocyte, neutrophil, and lymphocyte counts, as well as serum triglycerides, fasting glucose and protein parameters, including total protein, albumin, globulin, and albumin/globulin ratio (A/G), were analyzed. Twenty-five GAgP patients received non-surgical treatment and the clinical and blood parameters 3 to 7 years after treatment were re-evaluated. Clinical and hematological parameters of the two groups were compared. Comparisons of clinical and hematologic parameters pre- and post-treatment in GAgP group were performed through one-way ANOVA and paired-t test.


RESULTS
Elevated white blood cells, neutrophil numbers and serum total protein, globulin levels were observed in patients with GAgP compared to controls[(6.3 ± 2.0)×10(9)cell/L vs.(5.4 ± 1.0)×10(9)cell/L, (4.1 ± 1.8)×10(9) cell/L vs.(3.0 ± 0.9)×10(9) cell/L, (78.2 ± 4.4) g/L vs. (75.6 ± 4.6) g/L and (29.3 ± 3.8) g/L vs.(26.5 ± 3.9) g/L respectively, P < 0.05]. A/G ratio was lower in the GAgP group than in the control group (1.7 ± 0.2 vs.1.9 ± 0.3, P < 0.01). Three to seven years after periodontal treatment, the reduction of PD and BI was observed in GAgP group(P < 0.05). There were significant decreases of WBC count, neutrophil count, serum total protein and globulin level, and significant increases of albumin level and A/G at 3 to 7 years after treatment(P < 0.05).


CONCLUSIONS
Non-surgical treatment may have long-term beneficial effect on the periodontal clinical status and hematologic parameters of generalized aggressive periodontitis.
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Xian-e
XE
Wang
Li
L
Xu
Huan-xin
HX
Meng
Da
D
Lü
Zhi-bin
ZB
Chen
Rui-fang
RF
Lu
D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood* / Q000628:therapy*; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D015992:Body Mass Index; D016022:Case-Control Studies; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D009504:Neutrophils / Q000473:pathology; D017622:Periodontal Attachment Loss / Q000097:blood; D010512:Periodontal Index; D016745:Root Planing; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D014081:Tooth Extraction; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D014280:Triglycerides