Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors.
OBJECTIVE
Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor.


METHODS
A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.


RESULTS
The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.


CONCLUSIONS
The chemoprevention diet had a protective effect against tumor development in the mouse lungs.
Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75 - DK-2730 Herlev, Denmark. hcpommergaard@gmail.com.
Hans-Christian
HC
Pommergaard
Jakob
J
Burcharth
J
J
Rosenberg
Hans
H
Raskov
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002273:Carcinogens / Q000633:toxicity*; D004032:Diet; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D014807:Vitamin D / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D002273:Carcinogens; D014807:Vitamin D; D001241:Aspirin
Chemoprevention; acetylsalicylic acid; calcium; combination therapy; experimental model; lung cancer; tobacco carcinogens; vitamin D