Pharmacological evaluation and antifertility activity of Jatropha gossypifolia in rats.
OBJECTIVE
Pharmacological and antifertility activity evaluation of Jatropha gossypifolia in rats.


METHODS
The antifertility activity of the extracts of Jatropha gossypifolia in rats was evaluated using two experimental animal models. Estrogenic activity was evaluated in immature female rats using ethinyl estradiol as standard. Anti-implantation and early abortifacient activity was performed in female Wistar rats by determining the number of implantations and implantation resorptions.


RESULTS
In estrogenic activity evaluations, the ethanolic and aqueous extracts offered significant estrogen-like activity at 400 mg kg⁻¹ p.o. by increasing the uterine weight compared to vehicle control group. Ethanolic extract (400 mg kg⁻¹, p.o.) treatment significantly decreased the number of implants and increased the number of resorptions compared to vehicle control group.


CONCLUSIONS
The results of the present study provide the evidence of the anti-fertility activity of Jatropha gossypifolia as claimed in the traditional use. The results are consistent with the literature reports related to the antifertility effect of flower extracts of Jatropha gossypifolia.
Department of Pharmacognosy, College of Pharmacy, IPS Academy, AB Road, Indore, Madhya Pradesh 452012, India.
Sachin
S
Jain
Gajendra Pratap
GP
Choudhary
Dinesh Kumar
DK
Jain
D000818:Animals; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D031286:Jatropha / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D012098:Reproduction / Q000187:drug effects*
D010936:Plant Extracts; D004997:Ethinyl Estradiol