[Research progress in pathogenesis of IBD: the role of gut flora].
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the intestine. Both the etiology and the pathogenesis of IBD remain unclear. In recent years, the role of gut flora in IBD has become one of the most concerned issues. International metagenomic projects targeting the gut microbiota greatly promote the exploration of the role of gut flora in IBD. What are the characteristics of gut flora in IBD? How does it interact with host susceptibility? This review will discuss the enteric dysbacteriosis in IBD and show the interaction between gut flora, especially the dominant gut flora, and host susceptibility in IBD.
Department of Physiology and Pathophysiology Peking University Health Science Center, Beijing 100191, China.
Yu-Ting
YT
Xiang
Lin
L
Mei
D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology / Q000473:pathology*; D007422:Intestines / Q000382:microbiology*; D054892:Metagenome