Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.
Genetic variants of the methylenetetrahydrofolate reductase (MTHFR) gene involved in homocysteine metabolism may be important predictors of antipsychotic drug-induced weight gain (AIWG). We tested whether two functional MTHFR polymorphisms are related to AIWG. Weight gain was studied in two cohorts of first-episode, initially drug-naive schizophrenia patients; Chinese Han (n = 182) and Spanish Caucasians (n = 72) receiving antipsychotics for 10 wk and 3 months respectively. Blood DNA was genotyped for 677C/T and 1298A/C MTHFR polymorphisms. Patients with the 677 CC genotype had a significantly greater increase in BMI compared to T-allele carriers in both Chinese (p = 0.012) and Spanish (p = 0.017) samples. The 677C/T MTHFR polymorphism showed an additive effect, but no significant interaction, with the -759C/T HTR2C polymorphism previously associated with AIWG. These results suggest that the 677C/T MTHFR polymorphism might, along with the -759C/T HTR2C polymorphism and other genetic factors, provide a useful marker for the important and limiting side effect of AIWG.
Sheffield Hallam University, Sheffield, UK.
Umarat
U
Srisawat
Sheffield Hallam University, Sheffield, UK.
Gavin P
GP
Reynolds
ZhongDa Hospital and SouthEast University, Nanjing, China.
Zhi Jun
ZJ
Zhang
ZhongDa Hospital and SouthEast University, Nanjing, China.
Xiang Rong
XR
Zhang
Parc Sanitari Sant Joan de Deu, CIBERSAM, Barcelona, Spain.
Belen
B
Arranz
Parc Sanitari Sant Joan de Deu, CIBERSAM, Barcelona, Spain.
Luis
L
San
Sheffield Hallam University, Sheffield, UK.
Caroline F
CF
Dalton
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015992:Body Mass Index; D002681:China; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D004843:Epistasis, Genetic; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D013030:Spain; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*; D055815:Young Adult
D014150:Antipsychotic Agents; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)