Comparative effectiveness of renin-angiotensin system inhibitors in hypertension.
Hypertension is a chronic problem in the USA and there are three main ways to block the renin-angiotensin system: direct renin inhibitors, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). This article is a summary of a direct comparative effectiveness review of direct comparative trials in patients with hypertension. In patients with hypertension, ACEIs and ARBs provide similar blood pressure effects and no differences were seen in final health outcomes. ARBs have less ACE-induced cough and fewer withdrawals due to adverse events. Direct renin inhibitors versus ACE inhibitors or ARBs have not been extensively studied and their role is less clear.
University of Connecticut School of Pharmacy, 80 Seymour Street, Hartford, CT 06102-5037, USA. cmwhite@harthosp.org.
C Michael
CM
White
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
D000959:Antihypertensive Agents