Serum corin is reduced and predicts adverse outcome in non-ST-elevation acute coronary syndrome.
OBJECTIVE
The aim of the current study was to describe the role of corin, an enzyme that cleaves pro-atrial natriuretic peptide and pro-brain natriuretic peptide into their active peptides, in patients with acute coronary syndrome (ACS).


METHODS
Serum corin level was studied in patients with non-ST-elevation ACS who underwent percutaneous coronary intervention (n=152) and in control volunteers (n=103).


RESULTS
The corin level was lower in acute coronary syndrome patients (798±288 pg/ml) than in the controls (1165±613 pg/ml, p<0.0001). Those acute coronary syndrome patients who developed major adverse cardiovascular events (MACE; 60.9%) within 3 years of discharge had lower corin levels than the patients who did not experience major adverse cardiovascular events (698.16±233.67 vs. 952.1±297.81 pg/ml, p<0.0001). Using a multiple logistic regression model, corin level was a significant predictor of post-ACS MACE: p=0.0004 for 50 pg/ml steps, AUC 0.791, while p<0.0001, and AUC 0.804 using corin and brain natriuretic peptide as predictors.


CONCLUSIONS
Patients with non-ST-elevation ACS have lower serum corin levels than controls. Corin levels are lower in ACS patients who later experience MACE and thus might be predictor for MACE. This new putative biomarker may be useful, either alone or in combination with other biomarkers, for cardiovascular risk stratification assessment and outcome prediction in ACS patients.
The Baruch Padeh Medical Center, Poriya, Tiberias, Israel ; Bar-Ilan University, The Faculty of Medicine, Zefat, Israel.
Aviva
A
Peleg
Diab
D
Ghanim
Shiraz
S
Vered
Yonathan
Y
Hasin
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000628:therapy; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D012044:Regression Analysis; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000378:metabolism*; D016896:Treatment Outcome
D015415:Biomarkers; C119812:CORIN protein, human; D012697:Serine Endopeptidases
Acute coronary syndrome; brain natriuretic peptide; cardiovascular biomarker; corin