Lymphomatosis cerebri with intramedullary spinal cord involvement.
Lymphomatosis cerebri (LC) is a rare form of primary central nervous system lymphoma (PCNSL). Little is known about cases of LC with spinal cord involvement. Among the 11 PCNSL patients treated in our hospital during a four-year period, we identified two cases of LC with spinal cord lesions. One showed a spinal cord lesion followed by leukoencephalopathy. The other showed a spinal cord lesion after LC. In both cases, the histopathology was diffuse large B-cell lymphoma. It is possible that LC may affect the entire central nerve system, and tumor infiltration to the brain and spinal cord in LC may occur more frequently than has been previously considered.
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan.
Hiroyasu
H
Sato
Yoshimi
Y
Takahashi
Manabu
M
Wada
Yousuke
Y
Shiono
Ikuko
I
Suzuki
Kei
K
Kohno
Yuichi
Y
Kato
Toru
T
Kawanami
Kaori
K
Sakurada
Takamasa
T
Kayama
Takeo
T
Kato
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000175:diagnosis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology