Bile acid-mediated control of liver triglycerides.
Bile acids (BAs) are steroidal molecules generated in the liver by cholesterol oxidation. Beside their well-established role in lipid absorption and cholesterol homeostasis, they function as signaling molecules and activate dedicated BA receptors such as the farnesoid X receptor (FXR) and the G-protein coupled receptor TGR5. Through activation of downstream signaling pathways of these key receptors, BAs regulate not only their own synthesis and enterohepatic circulation, but also impact on hepatic lipid, glucose, and energy homeostasis. Therefore, BA-regulated signaling pathways have emerged as attractive targets for understanding the regulation of hepatic triglyceride metabolism in health and disease and treating fatty liver disease and associated metabolic disorders.
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Hans Popper Laboratory of Molecular Hepatology, Medical University of Vienna, Vienna, Austria.
Claudia
C
Fuchs
Thierry
T
Claudel
Michael
M
Trauner
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism* / Q000627:therapeutic use; D005234:Fatty Liver / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease; D015398:Signal Transduction; D014280:Triglycerides / Q000378:metabolism*
D001647:Bile Acids and Salts; D000960:Hypolipidemic Agents; D014280:Triglycerides