Hyperpolarized H2 O MR angiography.
OBJECTIVE
The aim of this study was to demonstrate that dissolution- dynamic nuclear polarization is capable of hyperpolarizing water protons and that the signal from the hyperpolarized bolus injection can be exploited in angiographic applications.


METHODS
We hyperpolarized water/glycerol using dynamic nuclear polarization followed by dissolution in D2 O.


RESULTS
A water (1) H signal enhancement of 77 times compared with 4.7 Tesla was obtained. This corresponds to a polarization of 3.5% for the 3.9 mol/L (1) H in D2 O . Moreover, a T1 in excess of 20 s was achieved.


CONCLUSIONS
The use of hyperpolarized water as a contrast agent presents a new opportunity to obtain MRA images with high contrast-to-noise in a fraction of a second.
Technical University of Denmark, Kgs Lyngby, Denmark; Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; GE Healthcare, Broendby, Denmark.
Jan H
JH
Ardenkjaer-Larsen
Christoffer
C
Laustsen
Sean
S
Bowen
Rahim
R
Rizi
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis; D017666:Deuterium Oxide / Q000138:chemical synthesis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D017666:Deuterium Oxide
angiography; dynamic nuclear polarization; hyperpolarization