A systematic review and meta-analysis of total thyroidectomy versus bilateral subtotal thyroidectomy for Graves' disease.
BACKGROUND
Our aim was to perform a meta-analysis of high-quality published trials, randomized and observational, comparing total thyroidectomy (TT) and bilateral subtotal thyroidectomy (ST) for Graves' disease.


METHODS
All studies published from 1970 to August 2012 were identified. All randomized controlled trials (RCTs) were included. Selection of high-quality, nonrandomized comparative studies (NRCTs) was based on a validated tool (Methodological Index for Nonrandomized Studies). Recurrent hyperthyroidism during follow-up, progression of ophthalmopathy, postoperative temporary and permanent hypoparathyroidism, and permanent recurrent laryngeal nerve (RLN) palsy were compared using odds ratios (ORs).


RESULTS
Twenty-three studies were included (4 RCTs and 19 NRCTs) compromising 3,242 patients (1,665 TT, 1,577 ST). TT was associated with a decrease in recurrent hyperthyroidism (P < .00001; OR, 0.10; 95% confidence interval [CI], 0.06-0.18), but with an increase in both temporary (P < .00001; OR, 2.70; 95% CI, 2.04-3.56) and permanent hypoparathyroidism (P = .005; OR, 2.91; 95% CI, 1.59-5.32). Progression of ophthalmopathy (P = .76; OR, 0.90; 95% CI, 0.48-1.71) and permanent RLN palsy (P = .82; OR, 0.91; 95% CI, 0.41-2.02) were similar.


CONCLUSIONS
TT offers a better chance of cure of hyperthyroidism than bilateral ST and can be accomplished safely with only a small increase in temporary and permanent hypoparathyroidism.
Department of General Surgery, Misericordia e Dolce Hospital, Prato, Italy. Electronic address: fferoci@yahoo.it.
Francesco
F
Feroci
Department of General Surgery, Misericordia e Dolce Hospital, Prato, Italy.
Marco
M
Rettori
Department of General Surgery, Misericordia e Dolce Hospital, Prato, Italy.
Andrea
A
Borrelli
Department of Nuclear Medicine, Misericordia e Dolce Hospital, Prato, Italy.
Angela
A
Coppola
Department of Nuclear Medicine, Misericordia e Dolce Hospital, Prato, Italy.
Antonio
A
Castagnoli
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy.
Giuliano
G
Perigli
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy.
Fabio
F
Cianchi
Department of General Surgery, Misericordia e Dolce Hospital, Prato, Italy.
Marco
M
Scatizzi
D006111:Graves Disease / Q000601:surgery*; D006801:Humans; D015233:Models, Statistical; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome