Pediatric perspective on pharmacogenomics.
The advances in high-throughput genomic technologies have improved the understanding of disease pathophysiology and have allowed a better characterization of drug response and toxicity based on individual genetic make up. Pharmacogenomics is being recognized as a valid approach used to identify patients who are more likely to respond to medication, or those in whom there is a high probability of developing severe adverse drug reactions. An increasing number of pharmacogenomic studies are being published, most include only adults. A few studies have shown the impact of pharmacogenomics in pediatrics, highlighting a key difference between children and adults, which is the contribution of developmental changes to therapeutic responses across different age groups. This review focuses on pharmacogenomic research in pediatrics, providing examples from common pediatric conditions and emphasizing their developmental context.
Institute of Human Development, Medical & Human Sciences, University of Manchester & Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, 5th Floor Research, Oxford Road, Manchester, M13 9WL, UK.
Adam
A
Stevens
Chiara
C
De Leonibus
Daniel
D
Hanson
Andrew
A
Whatmore
Philip
P
Murray
Rachelle
R
Donn
Stefan
S
Meyer
Pierre
P
Chatelain
Peter
P
Clayton
D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics; D016678:Genome / Q000235:genetics*; D023281:Genomics; D006801:Humans; D010372:Pediatrics / Q000379:methods*; D010597:Pharmacogenetics / Q000379:methods