HUS and TTP in Children.
This review describes the epidemiology, pathophysiology, presentation, clinical causes, treatment, and long-term prognosis of pediatric patients who present with thrombotic microangiopathy. The focus is on hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, the most common phenotypes of thrombotic microangiopathy.
Division of Nephrology, Department of Pediatrics, CTSI, NYU Langone Medical Center, 227 East 30th Street, Room #110, New York, NY 10016, USA. Electronic address: howard.trachtman@nyumc.org.
Howard
H
Trachtman
D002648:Child; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
Alternative pathway of complement (APC); Hemolytic uremic syndrome (HUS); Shiga toxin (Stx); Thrombotic microangiopathy (TMA); Thrombotic thrombocytopenic purpura (TTP)