Botulinum toxin type A in pregnancy.
OBJECTIVE
My patient received 62 units of botulinum toxin type A (BTX-A) for facial lines. Two weeks later, she found out that she was pregnant. Will this cause any harm to her fetus?


CONCLUSIONS
Botulinum toxin is not expected to be present in systemic circulation following proper intramuscular or intradermal injection. Moreover, BTX-A, which has a high molecular weight, does not appear to cross the placenta. From the 38 pregnancies reported in the literature, including women who had botulism poisoning during pregnancy, exposure to BTX-A does not appear to increase the risk of adverse outcome in the fetus.
Michael
M
Tan
Eunji
E
Kim
Gideon
G
Koren
Pina
P
Bozzo
D019274:Botulinum Toxins, Type A / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008431:Maternal-Fetal Exchange; D009465:Neuromuscular Agents / Q000009:adverse effects* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000517:prevention & control*; D015595:Skin Aging
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A