Illuminating liver fibrosis with vitamin D.
Hepatic fibrosis results from the accumulation of extracellular matrix-producing myofibroblasts in the liver. The mechanisms leading to the activation of hepatic stellate cells (HSCs) into myofibroblasts have been well described. By contrast, few molecular pathways leading to myofibroblast deactivation have been documented. Recently, the vitamin D-VDR axis has been shown to modulate HSC activity through a complex mechanism involving epigenetic modifications induced by the SMAD pathway.
Inserm UMR_S 938, CdR Saint-Antoine, 75012 Paris, France; UPMC Univ Paris 06, 75012 Paris, France.
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Firrincieli
Inserm UMR_S 938, CdR Saint-Antoine, 75012 Paris, France; UPMC Univ Paris 06, 75012 Paris, France.
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Braescu
Inserm UMR_S 938, CdR Saint-Antoine, 75012 Paris, France; UPMC Univ Paris 06, 75012 Paris, France; AP-HP, hôpital Saint-Antoine, service d'hépatologie, 75012 Paris, France.
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Housset
Inserm UMR_S 938, CdR Saint-Antoine, 75012 Paris, France; UPMC Univ Paris 06, 75012 Paris, France. Electronic address: nicolas.chignard@upmc.fr.
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Chignard
D000818:Animals; D053263:Gene Regulatory Networks; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D018167:Receptors, Calcitriol / Q000378:metabolism*; D015398:Signal Transduction
D018167:Receptors, Calcitriol