Levetiracetam following liver and kidney failure in late-onset anticonvulsant hypersensitivity syndrome.
Anticonvulsant hypersensitivity syndrome is an adverse drug reaction usually occurring from 1 to 8 weeks after exposure to antiepileptic drugs. It can threaten life by affecting the liver, kidneys, central nervous system or lungs. We present a 47-year-old patient treated with phenytoin, lamotrigine and clobazam for 7 years. He presented with hepatic and renal failure in relation to this syndrome demonstrated by renal biopsy. Prognosis was excellent due to an early diagnosis leading to cessation of the causative agents. Levetiracetam was started with a good response.
Department of Neurology, Hospital Clínico Universitario, Travesa da Choupana s/n, CP 15706 Santiago de Compostela (A Coruña), Spain. Electronic address: xiana.ro@gmail.com.
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Rodríguez-Osorio
Department of Neurology, Hospital Clínico Universitario, Travesa da Choupana s/n, CP 15706 Santiago de Compostela (A Coruña), Spain.
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Pardo
Department of Neurology, Hospital Clínico Universitario, Travesa da Choupana s/n, CP 15706 Santiago de Compostela (A Coruña), Spain.
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FJ
López-González
Department of Nephrology, Hospital Clínico Universitario, Santiago de Compostela, Spain.
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D
Novoa
Department of Pathology, Hospital Clínico Universitario, Santiago de Compostela, Spain.
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Pintos
D000927:Anticonvulsants / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D000077287:Levetiracetam; D017093:Liver Failure / Q000139:chemically induced / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced / Q000175:diagnosis*
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
Acute interstitial nephritis; Hypersensitivity syndrome; Late-onset; Levetiracetam