Towards fabrication of 3D printed medical devices to prevent biofilm formation.
The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization. The approach taken is very promising and can open up new avenues to manufacture functional medical devices in the future.
Drug-delivery and Pharmaceutical Technology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland. Electronic address: niklas.sandler@abo.fi.
Niklas
N
Sandler
Drug-delivery and Pharmaceutical Technology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Ida
I
Salmela
Drug Discovery and Pharmaceutical Biology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Adyary
A
Fallarero
Laboratory of Polymer Technology, Abo Akademi University, Biskopsgatan 8, FI-20500 Turku, Finland.
Ari
A
Rosling
Laboratory of Polymer Technology, Abo Akademi University, Biskopsgatan 8, FI-20500 Turku, Finland.
Mohammad
M
Khajeheian
Drug-delivery and Pharmaceutical Technology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Ruzica
R
Kolakovic
Drug-delivery and Pharmaceutical Technology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Natalja
N
Genina
Drug-delivery and Pharmaceutical Technology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Johan
J
Nyman
Drug Discovery and Pharmaceutical Biology, Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6A, FI-20520 Turku, Finland.
Pia
P
Vuorela
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D001287:Attachment Sites, Microbiological / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D004867:Equipment Design; D004864:Equipment and Supplies; D019981:Health Care Sector; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D010078:Oxazines / Q000008:administration & dosage / Q000737:chemistry; D011327:Printing; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D014966:Xanthenes / Q000008:administration & dosage / Q000737:chemistry
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D010078:Oxazines; D014966:Xanthenes; C005843:resazurin; D009582:Nitrofurantoin