2-Pyridonate titanium complexes for chemoselectivity. Accessing intramolecular hydroaminoalkylation over hydroamination.
Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively α-alkylated by C-H functionalization adjacent to nitrogen to access five- and six-membered cycloalkylamines with a good substrate-dependent diastereoselectivity of up to 19:1.
Department of Chemistry, University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
Eugene
E
Chong
Laurel L
LL
Schafer
D000475:Alkenes / Q000737:chemistry; D000478:Alkylation; D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D000475:Alkenes; D009942:Organometallic Compounds; D011725:Pyridines; D014025:Titanium