Kleine-levin syndrome treated with clarithromycin.
Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by periodic hypersomnia and various degrees of cognitive and behavioral disturbance, hyperphagia, and hypersexuality. Effective treatment is challenging. Stimulants marginally address sleepiness, but may increase irritability and do not improve cognitive and behavioral disturbances. Modafinil may shorten the symptomatic period but not the recurrence rate. Lithium and carbamazepine are beneficial in some cases, possibly related to similarities between KLS and affective disorders. Currently, no single medication is consistently successful in treating the syndrome. Here we report the short-term effect of clarithromycin in a patient with KLS.
University of Washington Medicine Sleep Center ; Department of Medicine, Division of Pulmonary and Critical Care, University of Washington.
Elham
E
Rezvanian
Nathaniel F
NF
Watson
D000328:Adult; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000188:drug therapy*; D011500:Protein Synthesis Inhibitors / Q000627:therapeutic use*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D011500:Protein Synthesis Inhibitors; D017291:Clarithromycin
Kleine-Levin; clarithromycin; hypersomnia