The yeast sphingolipid signaling landscape.
Sphingolipids are recognized as signaling mediators in a growing number of pathways, and represent potential targets to address many diseases. The study of sphingolipid signaling in yeast has created a number of breakthroughs in the field, and has the potential to lead future advances. The aim of this article is to provide an inclusive view of two major frontiers in yeast sphingolipid signaling. In the first section, several key studies in the field of sphingolipidomics are consolidated to create a yeast sphingolipidome that ranks nearly all known sphingolipid species by their level in a resting yeast cell. The second section presents an overview of most known phenotypes identified for sphingolipid gene mutants, presented with the intention of illuminating not yet discovered connections outside and inside of the field.
Dept. Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States. Electronic address: montefus@musc.edu.
David J
DJ
Montefusco
Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States.
Nabil
N
Matmati
Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States. Electronic address: Yusuf.Hannun@stonybrookmedicine.edu.
Yusuf A
YA
Hannun
D006801:Humans; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction; D013107:Sphingolipids / Q000378:metabolism*
D013107:Sphingolipids
Lipidomics; Signaling; Sphingolipid; Yeast