Killing tumors by keeping ras and PI3' kinase apart.
Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110α interaction for full activation of PI3K and tumor maintenance.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Tina L
TL
Yuan
Frank
F
McCormick
D000230:Adenocarcinoma / Q000201:enzymology*; D000818:Animals; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
C509622:1-phosphatidylinositol 3-kinase p110 subunit, mouse; D058534:Class I Phosphatidylinositol 3-Kinases; C495971:Hras protein, mouse; D016283:Proto-Oncogene Proteins p21(ras)