Liquid-phase combinatorial library synthesis: recent advances and future perspectives.
Liquid-phase combinatorial library synthesis is commonly developed into the viable alternatives or adjunct across the broad spectrum of polymer-supported organic chemistry. It includes the use of soluble polymer supports in the combinatorial synthesis of peptides and small-molecular library compounds which act as catalyst and reagent supports. It also includes high throughput biological screening with generation and evaluation of chemical leads for drug discovery development. In this review, liquid-phase combinatorial library synthesis is shown as the most efficient method of choice for the synthesis of most of the combinatorial library compounds with specific approaches from different groups that state potentials of solution-phase combinatorial synthesis.
Kuldipsinh P
KP
Barot
Stoyanka
S
Nikolova
Illiyan
I
Ivanov
Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad-382481, Gujarat, India. manjunath.ghate@nirmauni.ac.in.
Manjunath D
MD
Ghate
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D055808:Drug Discovery / Q000295:instrumentation / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000295:instrumentation / Q000379:methods*; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry
D019151:Peptide Library; D010455:Peptides; D054852:Small Molecule Libraries