Sox4you: a new player in C/EBPα leukemia.
Although CEBPA mutations are among the most common genetic abnormalities in acute myeloid leukemia (AML), the transformation mechanism remains largely obscure. In this issue of Cancer Cell, Zhang and colleagues report that SOX4 is a direct target and crucial mediator of C/EBPα mutants in AML, revealing a potential therapeutic avenue.
Leukaemia and Stem Cell Biology Section, Division of Cancer Studies, Department of Haematological Medicine, King's College London, London SE5 9NU, UK.
Tsz Kan
TK
Fung
Anskar Yu Hung
AY
Leung
Chi Wai Eric
CW
So
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D055751:SOXC Transcription Factors / Q000235:genetics*
D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; C083431:SOX4 protein, human; D055751:SOXC Transcription Factors