Cross-coupling of remote meta-C-H bonds directed by a U-shaped template.
meta-C-H arylation and methylation of 3-phenylpropanoic acid and phenolic derivatives were developed using an easily removable nitrile template. The combination of a weakly coordinating U-shaped template and mono-protected amino acid ligand was crucial for the cross-coupling of C-H bonds with organoborons.
Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Li
L
Wan
Navid
N
Dastbaravardeh
Gang
G
Li
Jin-Quan
JQ
Yu
D001896:Boron Compounds / Q000737:chemistry; D008745:Methylation; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry*
D001896:Boron Compounds; D009570:Nitriles; D010636:Phenols; D010666:Phenylpropionates; C035253:3-phenylpropionic acid; D010165:Palladium