Chronic kidney disease and hypothalamic-pituitary axis dysfunction: the chicken or the egg?
Hormonal derangements at the level of the hypothalamic-pituitary axis are often seen with the worsening of kidney function. This may not be surprising given the role of the kidney in synthesis, metabolism and elimination of many of these hormones. Traditionally, these derangements have been understood as a consequence of kidney failure. Conversely, recent evidence points towards the implication of such hormonal disorders in the genesis of CKD. In this review we present arguments supporting both the role of hypothalamic-pituitary axis dysfunction as a consequence of uremic complications and a culprit in disease incidence and progression. Focus is given to evidence regarding thyroidal, adrenal and gonadal axes.
Division of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Christiaan Lucas
CL
Meuwese
Juan Jesús
JJ
Carrero
D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000307:Adrenal Gland Diseases / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*; D015994:Incidence; D010900:Pituitary Diseases / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones
Aldosterone; Cortisol; Estrogen; Hemodialysis; Inflammation; Prolactin; Testosterone; Thyroid; Triiodothyronine