Periodic leg movements are associated with reduced sleep quality in older men: the MrOS Sleep Study.
OBJECTIVE
Periodic limb movements in sleep (PLMS) are common in the elderly. A previous large polysomnographic (PSG) study examining the relationship of PLMS to sleep architecture and arousals from sleep in women found that leg movements were common in elderly women, and PLMS which were associated with EEG arousals had a strong and consistent association with markers of disturbed sleep. Since sleep differs in men and women, we now investigate the association between PLMS and PSG indices of sleep quality in a large community-based sample of older men.


METHODS
Observational study, cross-sectional analyses.


METHODS
Six clinical sites participating in the Osteoporotic Fractures in Men (MrOS) Study.


METHODS
2,872 older community-dwelling men (mean age 76.4 years) who completed in-home PSG from 2003-2005.


METHODS
N/A.


RESULTS
In-home PSG was performed which included bilateral measurement of leg movements. The total number of leg movements per hour of sleep (PLMI) and the number of leg movements causing EEG-documented arousals per hour of sleep (PLMA) were computed. A PLMI ≥ 5 (70.8%) and PLMA ≥ 5 (27.4%) were both prevalent. Linear regression models were used to examine the relationship between PLMS as predictors and sleep architecture, arousal index, and sleep efficiency as outcomes. The highest quintiles of PLMI (≥ 65.1) and PLMA (≥ 6.8) showed the largest association with indices of sleep architecture; PLMA showed a larger magnitude of effect. After multivariate adjustment, participants with a higher PLMA had a small but significantly higher arousal index, lower sleep efficiency, higher percentages of stages 1 and 2 sleep, and lower percentages of stage 3-4 and REM sleep (p < 0.01). An increased PLMI was similarly associated with a higher arousal index, higher percentage of stage 2 sleep, and lower percentage of stage 3-4 (p < 0.0001), but not with an increase in stage 1, REM sleep, or sleep efficiency. Neither PLMI nor PMLA was associated with subjective sleepiness measured by the Epworth Sleepiness Scale.


CONCLUSIONS
This study demonstrated that periodic leg movements are very common in older community-dwelling men and regardless of associated arousals, are associated with evidence of lighter and more fragmented sleep.
University of California, San Francisco, San Francisco, CA.
David M
DM
Claman
Susan K
SK
Ewing
Susan
S
Redline
Sonia
S
Ancoli-Israel
Jane A
JA
Cauley
Katie L
KL
Stone
D000368:Aged; D015984:Causality; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004569:Electroencephalography / Q000379:methods; D015577:Geriatric Assessment / Q000379:methods* / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D020189:Nocturnal Myoclonus Syndrome / Q000453:epidemiology* / Q000503:physiopathology; D017286:Polysomnography; D012890:Sleep / Q000502:physiology; D007319:Sleep Initiation and Maintenance Disorders / Q000453:epidemiology* / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology; D014481:United States / Q000453:epidemiology
Periodic limb movements; aging; geriatric; men; sleep; sleep EEG arousals; sleep stage