Eosinophilic fasciitis associated with hypereosinophilia, abnormal bone-marrow karyotype and inversion of chromosome 5.
We report the case of a male patient presenting with eosinophilia, pulmonary oedema and eosinophilic fasciitis (EF). He had the classic clinical appearance and magnetic resonance imaging of EF. Cytogenetic analysis of the bone marrow revealed a previously undescribed pericentric inversion of chromosome 5. Overall, the presentation was consistent with a diagnosis of chronic eosinophilic leukaemia, not otherwise specified (CEL-NOS). Dermatologists should consult a haematologist in cases of EF, in order to rule out possible haematological malignancies.
Department of Dermatology, St George's Hospital, London, UK.
J S
JS
Ferguson
J
J
Bosworth
T
T
Min
J
J
Mercieca
C A
CA
Holden
D000368:Aged; D001853:Bone Marrow; D007446:Chromosome Inversion; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D004802:Eosinophilia / Q000235:genetics* / Q000473:pathology; D005208:Fasciitis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D059785:Karyotype; D008297:Male