Effects of whole body vibration plus diet on insulin-resistance in middle-aged obese subjects.
We investigated the early effects of whole body vibration (WBV) added to hypocaloric diet on insulin-resistance and other parameters associated with glucose regulation in sedentary obese individuals. We randomly assigned 34 patients to WBV plus hypocaloric diet (WBV group) or diet alone (CON group) for 8 weeks. Fasting and post-load glucose, insulin, lipids, C-reactive protein, tumor necrosis factor-α, leptin, adiponectin were assessed. Insulin sensitivity index (ISI) was derived from oral-glucose-tolerance test. Body composition was evaluated with dual-energy X-ray absorptiometry. Both groups lost approximately 5% of weight, with greater reduction of body fat in WBV than in CON (-7.1±1.2 Kg vs. -5.3±1.0 Kg, p=0.003). Percent variation of ISI was more pronounced in WBV than in CON group (+35±4% vs. + 22±5%, p=0.002), accompanied by slight improvement in post-load glucose (-1.07±0.02 vs. - 0.12±0.01 mmol/l, p=0.031) but without changes in fasting levels. Adiponectin significantly increased in WBV group compared with CON (p=0.021 for comparison) whereas no differences in leptin and inflammatory markers were observed. In middle-aged sedentary obese subjects, WBV added to hypocaloric diet for 8 weeks improved body composition, insulin-resistance, glucose regulation and adiponectin levels to a greater extent compared with diet alone. Efficacy and feasibility of this approach in the long term need to be ascertained.
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Bellia
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Sallì
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Lombardo
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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D'Adamo
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Guglielmi
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Tirabasso
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Giordani
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Federici
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Lauro
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
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Foti
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
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P
Sbraccia
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy*; D057185:Sedentary Behavior; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014732:Vibration
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein