The genetic overlap between schizophrenia and height.
Epidemiological studies suggest that height and schizophrenia risk are inversely correlated. These findings might arise because i) height and schizophrenia share genetic variants and ii) the effects of these shared variants are in opposite direction for the two traits. We use genome wide association data to empirically evaluate these hypotheses. We find that variants which impact on height and risk for schizophrenia are distributed across several genomic regions and the directions of effect vary, some consistent and others inconsistent with the direction expected from the phenotypic data. Moreover, signals that were in and not in accord with the phenotypic data aggregated in distinct biological pathways.
Department of Psychiatry, Virginia Commonwealth University, United States. Electronic address: sabacanu@vcu.edu.
Silviu-Alin
SA
Bacanu
Xianging
X
Chen
Kenneth S
KS
Kendler
D001827:Body Height / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
Network analysis; Shrinkage; Suggestive signals