[Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats].
OBJECTIVE
To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.


METHODS
The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program.


RESULTS
The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL( 2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively.


CONCLUSIONS
There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats.
College of Pharmacy,Jilin Medical College, Jilin 132013, China. fengbo2@sina.com
Bo
B
Feng
He-Yun
HY
Zhu
Jiao
J
Guan
Cheng-Yi
CY
Hao
Jing-Can
JC
Duan
Jing-Kai
JK
Gu
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D029965:Gentianaceae / Q000737:chemistry*; D057888:Iridoid Glucosides / Q000097:blood* / Q000493:pharmacokinetics*; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D057888:Iridoid Glucosides; C012997:gentiopicroside