The association between serum Dickkopf-1 levels and esophageal squamous cell carcinoma.
Serum Dickkopf-1(DKK-1) is elevated in many malignancies and is an important indicator of malignant potential. However, its significance in esophageal squamous cell cancer (ESCC) has not yet been clarified. We hypothesized a role for DKK-1 in patients with ESCC. The study consisted of 90 ESCC patients and 85 healthy controls. After diagnosis, the level of DKK-1 was measured in the serum samples by enzyme-linked immunosorbent assay and the levels of DKK-1 were much higher in the ESCC patients than in the healthy control group (p < 0.0001). For serum DKK-1, the sensitivity and specificity of the assay were 70 and 80%, respectively. The preoperative serum DKK-1 level was elevated in the ESCC patients. Although serum DKK-1 is not a specific biomarker for ESCC, it might be a useful marker for the diagnosis and treatment of ESCC.
Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey hbegenik@gmail.com.
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Begenik
Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
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Kemik
Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
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Emre
Department of Gastroenterology, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
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Dulger
Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
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Demirkiran
Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
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Ebinc
Department of General Surgery, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
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Kemik
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004938:Esophageal Neoplasms / Q000097:blood* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D015854:Up-Regulation
D014408:Biomarkers, Tumor; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins
Dickkopf-1; Esophageal squamous cell cancer