Semaphorin7A: branching beyond axonal guidance and into immunity.
Semaphorins are a family of proteins that were originally described for their role in axonal guidance. Studies now show that semaphorins encompass many physiological functions outside of the nervous system, including immune responses. Semaphorin7A (SEMA7A) belongs to the "immune" semaphorin group and has been shown to play a crucial role in regulating immune responses. In this review, we discuss the structure and function of SEMA7A as well as its role in innate and adaptive immunity [corrected].We further describe SEMA7A's involvement in inflammatory disease and its emergent role in cancer.
Department of Biomedical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431-0991, USA.
Ramon
R
Garcia-Areas
Stephania
S
Libreros
Vijaya
V
Iragavarapu-Charyulu
D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D039961:Semaphorins / Q000276:immunology* / Q000502:physiology
D011991:Receptors, Virus; D039961:Semaphorins; C112038:VESPR semaphorin receptor