[Pathogenetic percularities of fetal distress in pregnant women with preeclampsia].
It was performed the investigation of the fetal regulatory systems condition with the heart rate variability method application in 94 women with preeclampsia. It was established that preeclamptic patients had thrombophilia that was accompanied by increased reversible aggregation of platelets in response to low doses of ADP and collagen stimulation. The fetal deterioration in this group was characterized by decreased fetal heart rate variability fractal components with a relative predominance of the central sympathetic control circuit. The augmented sympathetic tone played the significant role in fetal rigid rhythm and decelerations appearance and has formed the fetal myocardium hypoxic injury and the suppressed sinus node response. The usage of semisynthetic diosmin 1 tablet (600 mg) 2 times daily in preeclamptic ladies has a pronounced disaggregant effect and improved fetal autonomic nervous regulation in its projections on hemodynamics. The restoration of the fetal cardiorespiratory synchronization periods has made it possible to consider that diosmine has neuroprotective effect that was directed on the fetal regulatory systems condition optimization.
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D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology*; D002449:Cell Aggregation / Q000187:drug effects*; D004145:Diosmin / Q000008:administration & dosage; D005260:Female; D006339:Heart Rate; D006801:Humans; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D004145:Diosmin