Involvement of strictosidine as a defensive chemical inCatharanthus roseus.
The involvement of the glucoalkaloid strictosidine in antimicrobial and antifeedant activity inCatharanthus roseus leaves was investigated. Strictosidine and its deglucosylation product, specifically formed by the enzyme strictosidine glucosidase, were shown to be active against several microorganisms. In contrast, neither the intact glucoside, nor the aglycone product(s) was found to exhibit antifeedant activity againstSpodoptera exigua larvae, as was found for intactC. roseus leaves and leaf extracts. Besides alkaloids further downstream in the biosynthesis pathway, a more apolar, yet unidentified compound may be involved in this activity.
Division of Pharmacognosy, Leiden Amsterdam Center for Drug Research Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
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Luijendijk
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van der Meijden
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Verpoorte