Transcriptional regulation of T helper type 2 differentiation.
Considerable progress has been made in recent years towards our understanding of the molecular mechanisms of transcriptional regulation of T helper type 2 (Th2) cell differentiation. Additional transcription factors and chromatin-modifying factors were identified and shown to promote Th2 cell differentiation and inhibit differentiation into other subsets. Analyses of mice lacking several cis-regulatory elements have yielded more insight into the regulatory mechanism of Th2 cytokine genes. Gene deletion studies of several chromatin modifiers confirmed their impact on CD4 T-cell differentiation. In addition, recent genome-wide analyses of transcription factor binding and chromatin status revealed unexpected roles of these factors in Th2-cell differentiation. In this review, these recent findings and their implication are summarized.
Department of Life Science, Sogang University, Seoul, Korea.
Gap Ryol
GR
Lee
D000818:Animals; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D050436:Regulatory Elements, Transcriptional; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D016207:Cytokines; D014157:Transcription Factors
T helper type 2; cis-regulatory element; differentiation; epigenetics; transcription factor