Giant neonatal thoraco-abdominal lymphatic malformations treated with sildenafil: a case report and review of the literature.
Lymphatic malformations account for approximately 5% of benign tumors encountered during the neonatal period. Most often treated by surgical resection or sclerotherapy, phosphodiesterase inhibitors have recently emerged as a potential treatment modality for lymphatic malformations. Treatment with phosphodiesterase inhibitors may be particularly useful when patients are not candidates for surgical resection or sclerotherapy. We report a case of giant bilateral lymphatic malformations diagnosed prenatally and treated postnatally with sildenafil.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, MO, USA.
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Singh
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Singh
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Mundy
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D044148:Lymphatic Abnormalities / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011687:Purines / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000473:pathology* / Q000628:therapy; D015911:Sclerotherapy; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D016216:Ultrasonography, Prenatal
D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate
Lymphatic malformations; giant; neonatal; sildenafil