Henoch-Schönlein purpura (HSP) and high-dose immunoglobulin treatment in patient with familiar prostatic adenocarcinoma.
A 52-y old man was admitted to our Department because of abdominal pains and diarrhea with fresh blood, with concomitant purpura over the whole body and edema of the both tarsal joints. The medical history of the patient included skin changes of similar character identified once 10-12 y before. The family history revealed prostate cancer (brother and father) and pulmonary carcinoma (mother and mother's sister). An administration of immunoglobulins in the course of HSP is a non-standard clinical procedure and in case of our patient--clinically effective. In the literature, we have found only few articles about intravenous immunoglobulin treatment for acute, adult-onset HSP and only one article about GI bleeding from colonic ecchymoses in HSP. In these cases HSP wasn't associated with prostate cancer. In the first article, authors had seen dramatic responses to intravenous immunoglobulin, like in the case presented by us. IV-IG acts as an immunomodulator by suppression of antibody production, Fc-receptor blockade and anti-idiotypic reaction. In our case, the last two mechanisms could be perceived as favorable effects of IV-IG.
Department of Pathophysiology; Medical University; Wrocław, Poland.
Małgorzata
M
Sobieszczańska
Department of Internal Diseases; Voivodship Hospital; Opole, Poland.
Sławomir
S
Tubek
Department of Internal Diseases; Voivodship Hospital; Opole, Poland.
Dagmara
D
Poplicha
Department of Internal Diseases; Voivodship Hospital; Opole, Poland.
Anna
A
Grabelus
Department of Internal Diseases; Voivodship Hospital; Opole, Poland.
Jacek
J
Pawełczak
D000230:Adenocarcinoma / Q000150:complications*; D006471:Gastrointestinal Hemorrhage / Q000473:pathology*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000628:therapy*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications*; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous
GI bleeding; Henoch-Schönlein purpura; amiliar prostatic adenocarcinoma; diabetes; immunoglobulin treatment