Antibacterial activity of gemini quaternary ammonium salts.
A series of gemini quaternary ammonium salts (chlorides and bromides), with various hydrocarbon chain and spacer lengths, were tested. These compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria and were not mutagenic. The strongest antibacterial effect was observed for TMPG-10 Cl (against Pseudomonas aeruginosa ATCC 27853) and TMPG-12 Br (against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 11229 and clinical ESBL(+) isolate 434) surfactants. These compounds inhibited the adhesion of Staphylococcus epidermidis ATCC 35984 to a polystyrene surface and eradicated biofilm formed by P. aeruginosa PAO1. The activity of studied compounds was dependent on hydrocarbon chain length.
Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland.
Ewa
E
Obłąk
Agata
A
Piecuch
Katarzyna
K
Guz-Regner
Ewa
E
Dworniczek
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012756:Sheep
D000900:Anti-Bacterial Agents; D000644:Quaternary Ammonium Compounds
adhesion; biofilm; cationic surfactants; gemini quaternary ammonium salts