Getting by with a little help from the right CD4+T cells.
Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8+T cells are optimally recruited to neoplastic lesions when co-administered with TH1 polarized CD4+T cells that are also TAA-specific. However, in vitro TH1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4+and CD8+T cells.
Centre of Oncology, Geneva University Hospitals and University of Geneva; Geneva, Switzerland.
Sabine
S
Hoepner
Paul R
PR
Walker
T helper epitope; TH1 CD4+ T cells; TH2 CD4+ T cells; adoptive cell transfer; brain tumors; cytotoxic T lymphocytes; immunotherapy; tumor-associated antigens