Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development.
Replacement of irreversibly damaged organs due to chronic disease, with suitable tissue engineered implants is now a familiar area of interest to clinicians and multidisciplinary scientists. Ideal tissue engineering approaches require scaffolds to be tailor made to mimic physiological environments of interest with specific surface topographical and biological properties for optimal cell-material interactions. This study demonstrates a single-step procedure for inducing biomimicry in a novel nanocomposite base material scaffold, to re-create the extracellular matrix, which is required for stem cell integration and differentiation to mature cells. Fumed silica nanoparticle mediated procedure of scaffold functionalization, can be potentially adapted with multiple bioactive molecules to induce cellular biomimicry, in the development human organs. The proposed nanocomposite materials already in patients for number of implants, including world first synthetic trachea, tear ducts and vascular bypass graft.
UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK; Division of Surgery and Interventional Science, London, UK.
Achala
A
de Mel
Bala
B
Ramesh
David J
DJ
Scurr
Morgan R
MR
Alexander
George
G
Hamilton
Martin
M
Birchall
Alexander M
AM
Seifalian
D001187:Artificial Organs; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D001808:Blood Vessels / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects*; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009301:Nasolacrimal Duct / Q000166:cytology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds; D014132:Trachea / Q000166:cytology
D009842:Oligopeptides; D012822:Silicon Dioxide
artificial-organs; bioactivity; biofunctionalization; fumed-silica; nanomaterials