Dextran/Albumin hydrogel sealant for Dacron(R) vascular prosthesis.
In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. Prepared hydrogels were compared with similar, already known biomaterial made from gelatine with the same cross-linking agent. Obtained hydrogels, prepared from various ratios of oxidized dextran/albumin or oxidized dextran/gelatine, showed different cross-linking densities, which caused differences in swelling, degradation rate and mechanical properties. Permeability tests confirmed the complete tightness of the hydrogel-modified prosthesis. Results showed that application of the hydrogel coating provided leakage-free prosthesis and eliminated the need of pre-clotting.
Biomedical Engineering Laboratory, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland.
Anna
A
Lisman
Beata
B
Butruk
Iga
I
Wasiak
Tomasz
T
Ciach
D000418:Albumins / Q000737:chemistry*; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible; D003911:Dextrans / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared
D000418:Albumins; D020099:Coated Materials, Biocompatible; D003911:Dextrans; D020100:Hydrogels
Albumin; dextran; dextran oxidation; hydrogel; sealant; vascular prosthesis