Piecing together the puzzle of severe malaria.
Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identified as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these findings into new therapies.
Section of Paediatrics, Imperial College, Norfolk Place, London W2 1PG, UK.
Aubrey J
AJ
Cunnington
Michael
M
Walther
Eleanor M
EM
Riley
D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*; D010961:Plasmodium / Q000145:classification / Q000276:immunology; D012720:Severity of Illness Index