Prognostic impact of NDRG2 and NDRG3 in prostate cancer patients undergoing radical prostatectomy.
To investigate the clinicopathologic significance of NDRG2 and NDRG3, and their involvement in recurrence-free survival (RFS) and overall survival (OS) of prostate cancer (PCa).



NDRG2 and NDRG3 expression in 206 pairs of primary PCa and corresponding noncancerous prostate tissue samples from the same specimens were detected by immunohistochemistry. The association of NDRG2 and NDRG3 expression with the clinicopathologic features and with the prognosis of PCa was subsequently assessed.



In PCa tissues, NDRG2 expression was significantly downregulated, while NDRG3 expression was significantly upregulated (both P<0.001), compared with those in corresponding noncancerous prostate tissues. In addition, the downregulation of NDRG2 in PCa tissues was significantly correlated with advanced pathological stage (P=0.001), positive metastatic status (P=0.001) and high Gleason score (P=0.003), while the upregulation of NDRG3 in PCa tissues was significantly correlated with advanced pathological stage (P=0.006), positive metastatic status (P=0.001) and lymph node status (P=0.002). Furthermore, multivariate survival analysis showed low NDRG2 and high NDRG3 immunoreactivities were both significantly associated with short RFS and short OS in PCa independently of routine clinicopathological predictors.



Our data offer convincing evidence for the first time that the aberrant expression of NDRG2 and NDRG3 may contribute to the malignant progression of PCa. More importantly, both the downregulation of NDRG2 and the upregulation of NDRG3 may be efficient prognostic indicators for PCa.
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, China. guofren@163.com.
Guo-feng
GF
Ren
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, China.
Ling
L
Tang
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, China.
Ai-qing
AQ
Yang
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, China.
Wei-wei
WW
Jiang
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, China.
Yi-ming
YM
Huang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; C466228:NDRG2 protein, human; C431706:NDRG3 protein, human; D009419:Nerve Tissue Proteins; D025521:Tumor Suppressor Proteins