Synthesis and antioxidant activity of bis and tris heterocycles.
A variety of bis heterocycles, oxazolyl/thiazolyl/imidazolyl oxadiazoles having a styryl sulfonylmethyl group at the 5-position of oxadiazole and tris heterocycles having a pyrrolyl/pyrazolyl sulfonylmethyl group at the 5-position of oxadiazole were prepared adopting simple and versatile synthetic methodologies. All the compounds were screened for their antioxidant activities. Compound 5b displayed radical scavenging activity in all the three methods greater than the standard ascorbic acid, whereas compounds 8b and 14b showed activities equal to the standard ascorbic acid.
Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Nabhubygari
N
Mahaboob Basha
Dandu
D
Seenaiah
Adivireddy
A
Padmaja
Venkatapuram
V
Padmavathi
Desaraju Suresh
DS
Bhargav
Tartte
T
Vijaya
D001205:Ascorbic Acid / Q000494:pharmacology; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D015195:Drug Design; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry
D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006571:Heterocyclic Compounds; D010851:Picrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid
1,3,4-Oxadiazoles; Antioxidant activity; Pyrazole; Pyrrole