Formation of oxo-centered trinuclear chromium carboxylate complexes and hydrolysis of Cr3 as established by paramagnetic (2)H NMR spectroscopy.
Paramagnetic (2)H NMR techniques have been utilized to study the mechanism of formation of the oxo-bridged trinuclear Cr(III) carboxylate assembly [Cr3O(O2CCD3)6(H2O)3](+) from [Cr(H2O)6](3+) and d4-acetic acid. These studies reveal a complex mechanism dominated by the involvement of dinuclear intermediates. The oxo-bridged trinuclear Cr(III) carboxylate assembly [Cr3O(O2CCH2CH3)6(H2O)3](+) has been suggested for use as a chromium nutritional supplement and therapeutic agent as it is readily absorbed and has been proposed to enter cells intact. The paramagnetic (2)H NMR technique has been utilized to follow the stability of this Cr(III) carboxylate assembly in biologically relevant media; its stability is consistent with the assembly being able to enter cells intact.
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
April C
AC
Royer
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Kathryn
K
Russell
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Ken
K
Belmore
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA. Electronic address: jvincent@bama.ua.edu.
John B
JB
Vincent
D000085:Acetates / Q000737:chemistry; D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry*; D002857:Chromium / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000032:analysis* / Q000737:chemistry* / Q000493:pharmacokinetics; D004355:Drug Stability; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D014867:Water
D000085:Acetates; D002264:Carboxylic Acids; D056831:Coordination Complexes; D014867:Water; D002857:Chromium
Acetate; Chromium; Cr3; Propionate