The ChEMBL bioactivity database: an update.
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In particular, more comprehensive tracking of compounds from research stages through clinical development to market is provided through the inclusion of data from United States Adopted Name applications; a new richer data model for representing drug targets has been developed; and a number of methods have been put in place to allow users to more easily identify reliable data. Finally, access to ChEMBL is now available via a new Resource Description Framework format, in addition to the web-based interface, data downloads and web services.
European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
A Patrícia
AP
Bento
Anna
A
Gaulton
Anne
A
Hersey
Louisa J
LJ
Bellis
Jon
J
Chambers
Mark
M
Davies
Felix A
FA
Krüger
Yvonne
Y
Light
Lora
L
Mak
Shaun
S
McGlinchey
Michal
M
Nowotka
George
G
Papadatos
Rita
R
Santos
John P
JP
Overington
D001665:Binding Sites; D062126:Databases, Chemical; D055808:Drug Discovery; D006801:Humans; D020407:Internet; D008024:Ligands; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011506:Proteins / Q000737:chemistry / Q000187:drug effects
D008024:Ligands; D004364:Pharmaceutical Preparations; D011506:Proteins