Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium-induced ulcerative colitis in C57BL/6 mice.
The aim of this study was to determine the effects of resistant starch 3 (RS3) as a carrier for stachyose on dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. RS3 microspheres carrying stachyose (RS3 + stachyose) were produced and evaluated as a potentially improved colitis therapy for this study. The body weights of the mice treated with RS3 + stachyose were higher compared with those of DSS-treated control mice. RS3 + stachyose reduced the levels of the serum pro-inflammatory cytokines IL-6 and TNF-α to a greater extent compared with the same concentration of stachyose combined with ordinary starch (stachyose + starch). Histopathological examination of sections of colon tissues showed that the RS3 + stachyose group recovered well from colitis; however, the tissue sections of the stachyose + starch group presented necrosis to a more serious degree. These results suggest that stachyose with an RS3 carrier has better preventative effects on colitis than stachyose alone in mice.
College of Food Science, Southwest University, Chongqing 400715; ; Department of Biological and Chemical Engineering, Chongqing University of Education, Na'an, Chongqing 400067, P.R. China ;
Yu
Y
Qian
Xin
X
Zhao
Jia-LE
JL
Song
Kai
K
Zhu
Peng
P
Sun
Gui-Jie
GJ
Li
Rui
R
Wang
Jian-Quan
JQ
Kan
C57BL/6 mice; cytokine; resistant starch; stachyose