Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols.
Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex (iPr2)TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate (iPr2)TpZn-SR via reaction with thiols H-SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.
Department of Chemistry, Georgetown University, Box 571227-1227, Washington, D.C. 20057, USA. thw@georgetown.edu.
Allan Jay P
AJ
Cardenas
Rebecca
R
Abelman
Timothy H
TH
Warren
D032701:Biomimetics; D001881:Borates / Q000737:chemistry; D008958:Models, Molecular; D009569:Nitric Oxide / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D001881:Borates; D009573:Nitrites; D011720:Pyrazoles; D026403:S-Nitrosothiols; C555951:tris(pyrazolyl)borate; D009569:Nitric Oxide; D015032:Zinc