Fe-salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-InIII CPPs for selectively killing cancer cells.
We propose a modular synthetic strategy to constitute metallosalphen prodrugs in the form of coordination polymer nanoparticles, comprising magnetite nanocrystal colloidal cluster as core and salphen-In(III) coordination polymer as shell. These composite nanoparticles are not only equipped with intense photoluminescence, sensitive magnetic responsiveness and pH-dependent degradability, but also serve as prodrugs to accomplish intercellular conversion from non-toxic nanoparticles (Fe3O4@Salphen-In(III)) to pharmacologically active complexes (Fe-salphen), allowing to specifically inhibit the proliferation of A549 cancer cells via caspase activation.
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai 200433, PR China.
Shuai
S
Xu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Science, No. 11, Beiyitiao Zhongguancun, Beijing 100190, PR China.
Jing
J
Liu
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai 200433, PR China.
Dian
D
Li
Institute of High Energy Physics Chinese Academy of Sciences, Beijing 100049, PR China.
Liming
L
Wang
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai 200433, PR China. Electronic address: guojia@fudan.edu.cn.
Jia
J
Guo
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai 200433, PR China.
Changchun
C
Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Science, No. 11, Beiyitiao Zhongguancun, Beijing 100190, PR China. Electronic address: chenchy@nanoctr.cn.
Chunying
C
Chen
D015153:Blotting, Western; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000473:pathology*; D010655:Phenylenediamines / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013818:Thermogravimetry
D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010655:Phenylenediamines; C545695:salphen; C000499:ferric oxide
Coordination polymer; Magnetic nanoparticle; Metal complex; Prodrug; Target drug delivery