Hemolytic uremic syndrome outbreak in Turkey in 2011.
The aim of this retrospective multicenter study was to define the epidemiological and clinical features and prognostic factors of the first diarrhea-related hemolytic uremic syndrome (D+HUS) outbreak in Turkey in 2011. All pediatric nephrology centers in Turkey were asked about D+HUS patients via e-mail. Seventy D+HUS patients (median age: 5.7 years) participated. The seasonal peak was around the 7th, 8th and 9th months with 44 cases, centered in the east Marmara region. No causative agent could be identified. The rate of neurological complications and mortality was 21.4% and 4.2%, respectively. Eculizumab was used in four cases. Two of them had severe neurological complications despite plasma exchange. Elevated polymorphonuclear leukocyte count during hospital admission was the predictor of both severe disease and poor outcome. Duration of prodrome was the predictor of poor outcome (p<0.05). In conclusion, the median age of the affected children was greater than in the previous reports, while clinical features and outcome were similar.
Division of Pediatric Nephrology, Department of Pediatrics, 1Kocaeli University Faculty of Medicine, Kocaeli, Turkey. zekinci@outlook.com.
Zelal
Z
Ekinci
Cengiz
C
Candan
Harika
H
Alpay
Nur
N
Canpolat
Sare Gülfem
SG
Akyüz
Zübeyde
Z
Gündüz
Ismail
I
Dursun
Kenan
K
Bek
Hasan
H
Dursun
Emel
E
Işıyel
Faruk
F
Öktem
Yılmaz
Y
Tabel
İpek
İ
Akil
Ali
A
Delibaş
Kaan
K
Gülleroğlu
Nurver
N
Akıncı
Nida
N
Dinçel
Ozan
O
Özkaya
Oğuz
O
Söylemezoğlu
D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D004196:Disease Outbreaks; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D009017:Morbidity / Q000639:trends; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014421:Turkey / Q000453:epidemiology