One-pot tandem synthesis of 2-arylquinazolines by a multicomponent cyclization reaction.
A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a simple and practical procedure to access 2-arylquinazolines.
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. yeleping@163.com.
Leping
L
Ye
Lin
L
Yu
Lijun
L
Zhu
Xiaodong
X
Xia
D000447:Aldehydes / Q000737:chemistry; D002563:Cerium / Q000737:chemistry; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry*
D000447:Aldehydes; D011799:Quinazolines; D002563:Cerium; C004653:ceric ammonium nitrate