Network medicine in disease analysis and therapeutics.
Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom-based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends.
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
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D016208:Databases, Factual; D004194:Disease / Q000145:classification* / Q000235:genetics*; D055808:Drug Discovery / Q000379:methods*; D058492:Drug Repositioning; D004358:Drug Therapy / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D057285:Precision Medicine; D049490:Systems Biology; D059467:Transcriptome