Surface coated Eu(OH)3 nanorods: a facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity.
The water-soluble and biocompatible D-glucuronic acid coated Eu(OH)3 nanorods (average thickness x average length = 9.0 x 118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at approximately 600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 microM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be approximately 0.1 mM. Therefore, D-glucuronic acid coated Eu(OH)3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of approximately 1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.
Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 702-701, South Korea.
Krishna
K
Kattel
Ja Young
JY
Park
Wenlong
W
Xu
Badrul Alam
BA
Bony
Woo Cheol
WC
Heo
Tirusew
T
Tegafaw
Cho Rong
CR
Kim
M Wasi
MW
Ahmad
Seonguk
S
Jin
Jong Su
JS
Baeck
Yongmin
Y
Chang
Tae Jeong
TJ
Kim
Ji Eun
JE
Bae
Kwon Seok
KS
Chae
Ji Yun
JY
Jeong
Gang Ho
GH
Lee
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000633:toxicity; D003287:Contrast Media / Q000138:chemical synthesis / Q000633:toxicity; D005063:Europium; D006801:Humans; D006878:Hydroxides / Q000138:chemical synthesis / Q000633:toxicity*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D043942:Nanotubes / Q000737:chemistry / Q000633:toxicity*
D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D006878:Hydroxides; D005063:Europium