Primary neuroendocrine carcinoma in oral cavity: two case reports and review of the literature.
Neuroendocrine carcinoma (NEC) is a tumor that occurs in different locations, particularly the lungs and larynx. The oral cavity is a rare site for a primary NEC. This report describes 2 cases of primary NEC in the oral cavity. Case 1 occurred in the anterior mandibular gingiva in a 25-year-old woman and presented with a special histologic appearance. This patient showed no evidence of recurrence 13 months after marginal resection of the anterior mandible. Case 2 was a primary NEC with some foci of squamous cell differentiation arising in the right buccal region in a 38-year-old woman. This patient showed no evidence of disease 8 months after tumor resection and postoperative iodine-125 brachytherapy. To the best of the authors' knowledge, case 1 is the youngest patient with NEC reported in the oral cavity to date in the English-language literature, and case 2 is the first report of a primary NEC in the buccal region.
Resident, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Bin-Zhang
BZ
Wu
Professor, Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China.
Yan
Y
Gao
Professor, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address: yibiaopku@163.com.
Biao
B
Yi
D000328:Adult; D014408:Biomarkers, Tumor; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002610:Cheek / Q000473:pathology; D054893:Cone-Beam Computed Tomography; D003937:Diagnosis, Differential; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D009062:Mouth Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*
D014408:Biomarkers, Tumor