Comparative effectiveness research in localized prostate cancer treatment.
Prostate-specific antigen testing has dramatically increased the incidence of localized prostate cancer. Most men with localized cancer attempt curative therapy, usually with surgery or radiation. However, there is uncertainty about whether and how to best treat these cancers. No published controlled trials have directly compared surgery against radiation or either treatment against active surveillance. Given the indolent nature of prostate cancer and the substantial risks of treatment-related harms, the effects of cancer and treatment on quality of life are important patient-centered outcomes. Comparative effectiveness research, using observational cohorts, claims data and simulation models, enables comparisons of treatments that have not been studied in controlled trials and captures real-world outcomes data to better support informed decision-making.
Department of Medicine, University of New Mexico, Albuquerque, NM, USA. rhoffman@unm.edu.
Richard M
RM
Hoffman
David F
DF
Penson
Anthony L
AL
Zietman
Michael J
MJ
Barry
D057186:Comparative Effectiveness Research; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D011471:Prostatic Neoplasms / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D057832:Watchful Waiting