Bioactive lignans from the trunk of Abies holophylla.
Six new lignans (1-6) were isolated from the trunk of Abies holophylla MAXIM, together with 11 known lignans (7-17). The structures of 1-7 were elucidated by spectroscopic methods, acid hydrolysis, and use of the modified Mosher's method. The effects of the isolates on nerve growth factor induction in a C6 rat glioma cell line were evaluated. Compounds 6, 7, and 13 showed significant induction of nerve growth factor secretion at concentrations of 10 μM. Compounds 1, 5, 6, and 16 showed moderate inhibitory effects on nitric oxide production in lipopolysaccharide-activated BV-2 cells (IC50 28.5-36.4 μM).
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
Chung Sub
CS
Kim
Oh Wook
OW
Kwon
Sun Yeou
SY
Kim
Kang Ro
KR
Lee
D028202:Abies / Q000737:chemistry*; D000818:Animals; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
C586135:(8R,9S,7'S,8'R)-4,4',7'-trihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan; D017705:Lignans; C586137:juniperigiside; C586136:ligraminol E 4-O-beta-D-xyloside; D009569:Nitric Oxide; D020932:Nerve Growth Factor