Synthesis of Au-Fe3O4 heterostructured nanoparticles for in vivo computed tomography and magnetic resonance dual model imaging.
Water-soluble Au-Fe3O4 heterostructured nanoparticles with high biocompatibility were synthesized and applied as a dual modality contrast agent. These nanoparticles present strong CT/MRI contrast enhancement in a rabbit model. Low concentrations of Au-Fe3O4 were found to obtain a similar effect to high concentrations of a commercial iodine agent in the CT image.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China. hongwei@suda.edu.cn panyue@suda.edu.cn.
Jing
J
Zhu
Yinjie
Y
Lu
Yonggang
Y
Li
Jiang
J
Jiang
Liang
L
Cheng
Zhuang
Z
Liu
Liang
L
Guo
Yue
Y
Pan
Hongwei
H
Gu
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006321:Heart / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D008954:Models, Biological; D011817:Rabbits; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D006046:Gold; D052203:Ferrosoferric Oxide