Carcinoma ex pleomorphic adenoma in the oral cavity: a huge oral cavity mass with neck metastasis.
Carcinoma ex pleomorphic adenoma (CEPA) is a rare, aggressive, poorly understood malignancy. In CEPA, an epithelial malignancy develops in association with a primary or recurrent benign pleomorphic adenoma. Carcinoma ex pleomorphic adenoma is very difficult to identify before surgery because the clinical presentation of many cases is similar to that of pleomorphic adenomas. The risk for malignancy increases with the duration of a mixed tumor. Treatment of CEPA must be individualized on the basis of the tumor location, involvement of adjacent structures, histologic subtype, and grade. The authors recently experienced a case of CEPA arising in the oral cavity with neck metastasis. The patient was a 70-year-old man presenting a huge mass that was present for 20 years and that slowly grew on the left side of the neck. We treated it with a total excision with wide margins and neck dissection. There was no recurrence during the follow-up period of 5 years up until now. We present a case of an unusually huge CEPA in the oral cavity.
From the Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Hyun Jun
HJ
Hong
Hyung Kwon
HK
Byeon
Seong Hoon
SH
Bae
Ah Young
AY
Park
Eun Chang
EC
Choi
Hong-Shik
HS
Choi
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary; D008949:Adenoma, Pleomorphic / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008297:Male; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010157:Palatal Neoplasms / Q000175:diagnosis*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*