Pediatric thrombophilia.
Pediatric thrombosis and thrombophilia are increasingly recognized and studied. In this article, both the inherited and acquired factors for the development of thrombosis in neonates and children are categorized using the elements of Virchow's triad: stasis, hypercoagulable state, and vascular injury. The indications and rationale for performing thrombophilia testing are described. Also included are discussions on who, how, when, and why to test. Finally, recommendations for the use of contraceptives for adolescent females with a family history of thrombosis are outlined.
Division of Hematology and Oncology, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Janet Y K
JY
Yang
Anthony K C
AK
Chan
D000293:Adolescent; D002648:Child; D006801:Humans; D007231:Infant, Newborn; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis / Q000209:etiology*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology*
Arterial ischemic stroke; Cerebral sinus venous thrombosis; Pediatric thrombosis; Thrombophilia; Venous thromboembolic event