GRowing an epidermal tumor.
The glucocorticoid receptor (GR), a member of the nuclear hormone family of transcription factors, has key physiological roles in many organs, including the skin. In this issue, Latorre et al. demonstrate that mice lacking GR in the epidermis exhibit increased vulnerability to chemical carcinogenesis. Evidence supporting an involvement of GR signaling in physiological and pathophysiological processes in skin is discussed.
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA. Electronic address: WB@gru.edu.
Wendy B
WB
Bollag
Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Molecular Medicine and Genetics, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA.
Carlos M
CM
Isales
D000818:Animals; D005260:Female; D015603:Keratinocytes / Q000166:cytology*; D008297:Male; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000502:physiology*; D012878:Skin Neoplasms / Q000235:genetics*
D011965:Receptors, Glucocorticoid