Induced neural lineage cells as repair kits: so close, yet so far away.
Transdifferentiation or direct reprogramming of somatic cells into neural lineage cells has provided an invaluable new tool to advance the regenerative neural medicine. Here, we provide an overview of the various strategies currently available for producing of induced neural lineage cells in vitro as well as the direct reprogramming of neural cells in vivo. We also discussing some of the challenges faced in harnessing the potential of induced neural lineage cells for biomedical applications.
School of Biology, College of Science, University of Tehran, Tehran, Iran; Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Fahimeh
F
Mirakhori
Bahman
B
Zeynali
Ghasem Hosseini
GH
Salekdeh
Hossein
H
Baharvand
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D060846:Cell Engineering / Q000379:methods*; D005786:Gene Expression Regulation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D009474:Neurons / Q000166:cytology*