Prenatal diagnosis of sex chromosome aneuploidies: experience at a mainland Chinese hospital.
The aim of this study is to assess the initial indications, frequency and termination rates of pregnancies with sex chromosome aneuploidies (SCAs), at a mainland Chinese hospital. A total of 56 cases (0.9%) with SCAs were identified in 6,515 pregnancies referred for fetal karyotyping. Turner syndrome was the most commonly diagnosed SCA in prenatal diagnosis (48.2%). The most common referral reason for pregnancies with Turner syndrome was cystic hygroma on ultrasonography. The main reasons for fetal karyotyping in other types of SCAs were a positive prenatal screening test and advanced maternal age. A total of 47 (84%) of the pregnancies with SCAs were terminated and nine (16%) continued. This study first reported the rate of SCAs detected at prenatal diagnosis and the outcomes of these pregnancies in mainland China, and showed a very high termination rate for pregnancies with SCAs.
Prenatal Diagnostic Center, Guangzhou Women and Children Medical Center, Guangzhou Medical University , Guangzhou, Guangdong , China.
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Liao
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Yi
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Li
D000782:Aneuploidy; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations / Q000706:statistics & numerical data*