[Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].
Using the experimental model of rat heart ischemia/reperfusion, it is established that zoniporide (inhibitor of Na+/H+ exchanger) produces a significant (1.4-fold) decrease in the area of myocardial necrosis, 2.1-fold decrease in the serum troponin I level, and 2-fold decrease in the severity of post-reperfusion arrhythmias.
N A
NA
Gurova
A A
AA
Spasov
A S
AS
Timofeeva
A A
AA
Zheltova
V Iu
VIu
Fedorchuk
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D019210:Troponin I / Q000097:blood*
D002316:Cardiotonic Agents; D006146:Guanidines; D011720:Pyrazoles; D019210:Troponin I; C424422:zoniporide