Nitric oxide releasing materials triggered by near-infrared excitation through tissue filters.
Novel materials for the phototherapeutic release of the bioregulator nitric oxide (nitrogen monoxide) are described. Also reported is a method for scanning these materials with a focused NIR beam to induce photouncaging while minimizing damage from local heating. The new materials consist of poly(dimethylsiloxane) composites with near-infrared-to-visible upconverting nanoparticles (UCNPs) that are cast into a biocompatible polymer disk (PD). These PDs are then impregnated with the photochemical nitric oxide precursor Roussin's black salt (RBS) to give UCNP_RBS_PD devices that generate NO when irradiated with 980 nm light. When the UCNP_RBS_PD composites were irradiated with NIR light through filters composed of porcine tissue, physiologically relevant NO concentrations were released, thus demonstrating the potential of such devices for minimally invasive phototherapeutic applications.
Department of Chemistry and Biochemistry, University of California, Santa Barbara , Santa Barbara, California 93106-9510, United States.
Peter T
PT
Burks
John V
JV
Garcia
Ricardo
R
GonzalezIrias
Jason T
JT
Tillman
Mutong
M
Niu
Alexander A
AA
Mikhailovsky
Jinping
J
Zhang
Fan
F
Zhang
Peter C
PC
Ford
D000818:Animals; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D005374:Filtration / Q000295:instrumentation; D016166:Free Radical Scavengers / Q000008:administration & dosage*; D058085:Iron Compounds / Q000737:chemistry; D008027:Light; D049449:Luminescence; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000008:administration & dosage*; D009603:Nitroso Compounds / Q000737:chemistry; D010782:Photolysis; D013552:Swine
D004129:Dimethylpolysiloxanes; D016166:Free Radical Scavengers; D058085:Iron Compounds; D009603:Nitroso Compounds; D009569:Nitric Oxide; C078952:Roussin's Black Salt; C013830:baysilon