Affective temperaments and antidepressant response in the clinical management of mood disorders.
BACKGROUND
The aim of this study was to investigate the presence of a relationship between affective temperament and antidepressant treatment response in mood disorder patients.


METHODS
The lifetime history of antidepressant response of 90 bipolar disorder patients and 88 major depressive disorder patients were retrospectively evaluated and then assigned to one of four subgroups: complete response (CR), partial response (PR), no response (NR), and antidepressant associated mania response (AAMR). Using TEMPS-Rio de Janeiro - the brief Brazilian version of TEMPS-A - we compared affective temperament subscale scores across these groups.


RESULTS
We observed a statistically significant relationship between depressive and anxious affective temperaments and no antidepressant response. In bipolar disorder patients, cyclothymic temperament (p<0.01) and hyperthymic temperament (p<0.05) were associated with antidepressant-associated mania. Hyperthymic temperament was associated with complete antidepressant responses in major depressive disorder patients.


CONCLUSIONS
The evaluation of antidepressant response was retrospective.


CONCLUSIONS
Our data are consistent with the theory that affective temperament traits are factors that can influence the antidepressant response and the recovery from depressive episodes, but more longitudinal studies are needed to confirm this theory and our findings.
Neuroscience Program, Federal University, Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Raul Soares Institute - FHEMIG, Belo Horizonte, MG, Brazil; Faculty of Medical Sciences of Minas Gerais - FCMMG, Belo Horizonte, MG, Brazil.
Alexandre
A
de Aguiar Ferreira
Neuroscience Program, Federal University, Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Alina Gomide
AG
Vasconcelos
Neuroscience Program, Federal University, Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Mental Health, Faculty of Medicine, Federal University, Minas Gerais, Av. Alfredo Balena, 190, Belo Horizonte, MG 30130-100, Brazil.
Fernando Silva
FS
Neves
Neuroscience Program, Federal University, Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Mental Health, Faculty of Medicine, Federal University, Minas Gerais, Av. Alfredo Balena, 190, Belo Horizonte, MG 30130-100, Brazil. Electronic address: correa@task.com.br.
Humberto
H
Correa
D000328:Adult; D000339:Affect; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D001938:Brazil; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013694:Temperament; D016896:Treatment Outcome
D000928:Antidepressive Agents
Affective temperament; Antidepressant response; Mood disorders; TEMPS-A; TEMPS-Rio de Janeiro