Heterostructured layered aluminosilicate-itraconazole nanohybrid for drug delivery system.
A nanohybrid, consisting of layered aluminosilicate as a host material and itraconazole as a guest molecule, was successfully synthesized through the interfacial intercalation reaction across the boundary between water and water-immiscible liquid at the various pH. According to the powder X-ray diffraction pattern, the basal spacing of the intraconazole-layered aluminosilicate nanohybrid increased from 14.7 to 22.7 A depending on the pH of the aqueous suspension. The total amounts of itraconazole in the hybrids were determined to be 2.3-25.4 wt% by HPLC analysis. The in vivo pharmacokinetics study was performed in rats in order to compare the absorptions of itraconazole for the itraconazole-layered aluminosilicate nanohybrid and a commercial product, Sporanox. The pharmacokinetic data for the nanohybrid and Sporanox showed that the mean area under the plasma concentration-time curve (AUC, 2477 +/- 898 ng x hr/mL and 2630 +/- 953 ng x hr/mL, respectively) and maximum concentration (Cmax, 225.4 +/- 77.4 ng x hr/mL and 223.6 +/- 51.9 ng x hr/mL, respectively), were within the bioequivalence (BE) range. Therefore, we concluded that this drug-layered aluminosilicate nanohybrid system has a great potential for its application in formulation of poorly soluble drugs.
Center for Intelligent Nano-Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea.
Jae-Hun
JH
Yang
Hyun
H
Jung
Su Yeon
SY
Kim
Chul Hyun
CH
Yo
Jin-Ho
JH
Choy
D000538:Aluminum Silicates / Q000737:chemistry*; D000818:Animals; D004058:Diffusion; D017964:Itraconazole / Q000008:administration & dosage* / Q000097:blood* / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008657:Metabolic Clearance Rate; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley
D000538:Aluminum Silicates; D053769:Nanocapsules; C049037:aluminosilicate; D017964:Itraconazole