Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine ActinomyceteSalinispora arenicola.
Six new anthraquinone-γ-pyrones, saliniquinones A-F (1-6), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomyceteSalinispora arenicola(strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds1-6were determined by analysis of NOESY NMR spectroscopic data and by comparison of circular dichroism and optical rotation data with model compounds found in the literature. Saliniquinone A (1) exhibited potent inhibition of the human colon adenocarcinoma cell line (HCT-116) with an IC50of 9.9 × 10-9M. In the context of the biosynthetic diversity ofS. arenicola, compounds1-6represent secondary metabolites that appear to be strain specific and thus occur outside of the core group of compounds commonly observed from this species.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.
Brian T
BT
Murphy
Tadigoppula
T
Narender
Christopher A
CA
Kauffman
Matthew
M
Woolery
Paul R
PR
Jensen
William
W
Fenical