Evaluation of subchronic inhalation toxicity of methylcyclopentane in rats.
The aim of this study was to verify subchronic inhalation toxicity of methylcyclopentane (CAS No. 96-37-7) in Sprague-Dawley rats. Four groups of 10 rats of each gender were exposed to methylcyclopentane vapor by whole-body inhalation at concentrations of 0, 290, 1300, or 5870 ppm for 6h per day, 5 days/week over a 13-week period. During the study period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. Exposure-related clinical signs (salivation and rubbing) were observed in both genders of the 5870 ppm group. There was an increase in liver weight for both genders but the kidney weight was only higher in females than controls. However, no toxicologically significant changes were observed in body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, or histopathology in any of the treatment groups. Under the present experimental conditions, the target organs were determined to be kidney and liver in rats. The no-observed-adverse-effect concentration was considered to be 1300 ppm/6h/day in rats.
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea; College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
Young-Su
YS
Yang
Chemical Safety and Health Research Center, Occupational Safety and Health Research Institute, KOSHA, Daejeon 305-380, Republic of Korea.
Sung-Bae
SB
Lee
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.
Seong-Jin
SJ
Choi
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.
Byoung-Seok
BS
Lee
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.
Jeong-Doo
JD
Heo
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.
Chang-Woo
CW
Song
Chemical Safety and Health Research Center, Occupational Safety and Health Research Institute, KOSHA, Daejeon 305-380, Republic of Korea.
Hyeon-Yeong
HY
Kim
College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address: toxkim@chonnam.ac.kr.
Jong-Choon
JC
Kim
Jeonbuk Department of Non-human Primate, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea. Electronic address: khlee@kitox.re.kr.
Kyuhong
K
Lee
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003517:Cyclopentanes / Q000633:toxicity*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D019570:Inhalation Exposure; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic
D003517:Cyclopentanes; C000591674:methylcyclopentane
Inhalation; Methylcyclopentane; Rats; Subchronic toxicity; Whole-body exposure