Membranes and mammalian glycolipid transferring proteins.
Glycolipids are synthesized in and on various organelles throughout the cell. Their trafficking inside the cell is complex and involves both vesicular and protein-mediated machineries. Most important for the bulk lipid transport is the vesicular system, however, lipids moved by transfer proteins are also becoming more characterized. Here we review the latest advances in the glycolipid transfer protein (GLTP) and the phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) field, from a membrane point of view.
Biochemistry, Department of Biosciences, Åbo Akademi University, Turku, Finland.
Jessica
J
Tuuf
Biochemistry, Department of Biosciences, Åbo Akademi University, Turku, Finland. Electronic address: pmattjus@abo.fi.
Peter
P
Mattjus
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D006017:Glycolipids / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D013110:Sphingosine / Q000737:chemistry / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D006017:Glycolipids; C030363:lipid transfer protein; D013110:Sphingosine
1,2-dipalmitoyl-sn-glycero-3-phosphocholine; 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine; ADP-ribosylation factor; ARF; DPPC; ER; FAPP1/2; FAPP2; FFAT; GCS; GLTP; GSL; GalCer; GlcCer; Glycosphingolipid; LacCer; Membrane binding; OSBP; PC; PE; PH; PI; PI3P; PI4P; PM; POPC; PS; SM; START; TGN; VAP; endoplasmic reticulum; galactosylceramide; glucosylceramide; glucosylceramide synthase; glycolipid transfer protein; glycosphingolipid; lactosylceramide; oxysterol-binding protein; phosphatidylcholine; phosphatidylethanolamine; phosphatidylinositol; phosphatidylinositol-3-phosphate; phosphatidylinositol-4-phosphate; phosphatidylserine; phosphoinositol 4-phosphate adaptor protein-1/2; plasma membrane; pleckstrin homology; sphingomyelin; steroidogenic acute regulatory protein (StAR)-related lipid transfer; trans-Golgi-network; two phenylalanines (FF) in an acidic tract; vesicle-associated membrane protein-associated protein