Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets.
This experiment was conducted to investigate the effects of oral administration of monosodium glutamate (MSG) on expression of genes for hepatic lipid and nitrogen metabolism in piglets. A total of 24 newborn pigs were assigned randomly into one of four treatments (n = 6/group). The doses of oral MSG administration, given at 8:00 and 18:00 to sow-reared piglets between 0 and 21 days of age, were 0 (control), 0.06 (low dose), 0.5 (intermediate dose), and 1 (high dose) g/kg body weight/day. At the end of the 3-week treatment, serum concentrations of total protein and high-density lipoprotein cholesterol in the intermediate dose group were elevated than those in the control group (P < 0.05). Hepatic mRNA levels for fatty acid synthase, acetyl-coA carboxylase, insulin-like growth factor-1, glutamate-oxaloacetate transaminase, and glutamate-pyruvate transaminase were higher in the middle-dose group (P < 0.05), compared with the control group. MSG administration did not affect hepatic mRNA levels for hormone-sensitive lipase or carnitine palmitoyl transferase-1. We conclude that oral MSG administration alters hepatic expression of certain genes for lipid and nitrogen metabolism in suckling piglets.
Key Laboratory of Agroecology and Processing Subtropical Region, Institute of Subtropical Agriculture, Research Center for Healthy Breeding Livestock and Poultry, Hunan Engineering and Research Center Animal and Poultry Science, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Chinese Academy of Science, Changsha, 410125, Hunan, China.
Gang
G
Chen
Jun
J
Zhang
Yuzhe
Y
Zhang
Peng
P
Liao
Tiejun
T
Li
Lixiang
L
Chen
Yulong
Y
Yin
Jinquan
J
Wang
Guoyao
G
Wu
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005421:Flavoring Agents / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D012970:Sodium Glutamate / Q000494:pharmacology*; D013552:Swine
D005421:Flavoring Agents; D012313:RNA; D009584:Nitrogen; D012970:Sodium Glutamate