Changes in physical performance in older women according to presence and treatment of diabetes mellitus.
OBJECTIVE
To determine whether older women with diabetes mellitus have a greater longitudinal decline in physical performance than those without and whether any decline differs according to insulin sensitizer use.


METHODS
Prospective cohort study.


METHODS
Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela, Pennsylvania.


METHODS
Community-dwelling women (mean age 78.5 ± 3.6) enrolled in the Study of Osteoporotic Fractures in 1997-98 and restudied 4.9 ± 0.6 years later (N = 2,864).


METHODS
Women were categorized as having no diabetes mellitus (n = 2,680) or having diabetes mellitus (n = 184). A prescription medication inventory was used to determine use of insulin sensitizers (metformin and thiazolidinedione). The outcomes were longitudinal changes in physical performance measures, including grip strength, usual walk speed, and rapid walk speed.


RESULTS
Estimates from fully adjusted models showed that women with diabetes mellitus had greater declines in usual walk speed (-0.16 m/s, 95% confidence interval (CI) = -0.19 to -0.14) and rapid walk speed (-0.21 m/s, 95% CI = -0.24 to -0.17) than those without (usual walk speed -0.11 m/s, 95% CI = -0.12 to -0.11, P < .001; rapid walk speed -0.15 m/s, 95% CI = -0.16 to -0.14; P = .005). Women with diabetes mellitus taking insulin sensitizers had less decline in usual walk speed than those not taking insulin sensitizers (P < .001). Declines in grip strength did not differ significantly by diabetes mellitus status or insulin sensitizer use.


CONCLUSIONS
Older women with diabetes mellitus have a greater decline in walk speed, but not grip strength, than older women without diabetes mellitus. Clinical studies in older adults to determine whether diabetes mellitus treatments such as insulin sensitizers can prevent loss in walk speed and mobility are needed.
Research Service, Veterans Affairs Medical Center, Portland, Oregon; Department of Medicine, Oregon Health & Science University, Portland, Oregon; Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Christine G
CG
Lee
Ann V
AV
Schwartz
Kristine
K
Yaffe
Teresa A
TA
Hillier
Erin S
ES
LeBlanc
Peggy M
PM
Cawthon
D000368:Aged; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D018737:Hand Strength; D006801:Humans; D011446:Prospective Studies; D016138:Walking
diabetes mellitus; elderly; insulin sensitizer; physical performance; walk speed