[Personalized medicine and breast cancer: anticipatory medicine, prognostic evaluation and therapeutic targeting].
Breast cancer is now considered as a large collection of distinct biological entities, the management of which is increasingly personalized. Personalized medicine - defined as a medicine, which uses molecular profiles, notably genetic profiles, from patients and/or tumors to tailor therapeutic decisions - is now introduced in the management of breast cancer at any stages: screening and prevention of hereditary forms, prognostic and predictive evaluation of early breast cancer, and, more recently, novel clinical trials in advanced breast cancer, where genetic characterization of tumor tissue based on genomics, including next-generation sequencing tools, is used to drive specific therapeutic targeting.
Institut Paoli-Calmettes, centre de recherche en cancérologie de Marseille, oncologie médicale, Aix-Marseille université, Inserm U1068, CNRS U7258, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
Anthony
A
Gonçalves
Institut Paoli-Calmettes, centre de recherche en cancérologie de Marseille, département d'anticipation et de suivi du cancer, Aix-Marseille université, Inserm U1068, CNRS U7258, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
Jessica
J
Moretta
Institut Paoli-Calmettes, centre de recherche en cancérologie de Marseille, département d'anticipation et de suivi du cancer, Aix-Marseille université, Inserm U1068, CNRS U7258, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
François
F
Eisinger
Institut Paoli-Calmettes, centre de recherche en cancérologie de Marseille, oncologie médicale, Aix-Marseille université, Inserm U1068, CNRS U7258, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
François
F
Bertucci
D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D005260:Female; D020869:Gene Expression Profiling; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D023281:Genomics; D006801:Humans; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D057285:Precision Medicine / Q000379:methods* / Q000639:trends
D014408:Biomarkers, Tumor; D005819:Genetic Markers
BRCA mutation; HER2; Ki67; biomarkers; breast cancer; hormone receptors; molecular subtypes; next-generation sequencing; personalized medicine