Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats.
The administration of flaxseed oil or flaxseed oil plus trientine in diabetic rats reduced triglyceride, very low density lipoprotein, and total cholesterol. Furthermore, the combined treatment significantly increased superoxide dismutase activity and attenuated serum Cu2+. The results suggest that the administration of flaxseed oil plus trientine is useful in controlling serum lipid abnormalities, oxidative stress, restoring heart structure, and reducing serum Cu2+ in diabetic rats.
Department of Biochemistry, Ilam University of Medical Sciences, Ilam, Iran.
Ali
A
Rezaei
Esfandiar
E
Heidarian
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002614:Chelating Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D006321:Heart / Q000033:anatomy & histology / Q000503:physiopathology*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008043:Linseed Oil / Q000008:administration & dosage* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014266:Trientine / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D002614:Chelating Agents; D008055:Lipids; D014280:Triglycerides; D003300:Copper; D008043:Linseed Oil; D002784:Cholesterol; D014266:Trientine