Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum.
Antimicrobial resistance (AMR) is now a global threat. Its emergence rests on antimicrobial overuse in humans and food-producing animals; globalization and suboptimal infection control facilitate its spread. While aggressive measures in some countries have led to the containment of some resistant gram-positive organisms, extensively resistant gram-negative organisms such as carbapenem-resistant enterobacteriaceae and pan-resistant Acinetobacter spp. continue their rapid spread. Antimicrobial conservation/stewardship programs have seen some measure of success in reducing antimicrobial overuse in humans, but their reach is limited to acute-care settings in high-income countries. Outside the European Union, there is scant or no oversight of antimicrobial administration to food-producing animals, while evidence mounts that this administration leads directly to resistant human infections. Both horizontal and vertical infection control measures can interrupt transmission among humans, but many of these are costly and essentially limited to high-income countries as well. Novel antimicrobials are urgently needed; in recent decades pharmaceutical companies have largely abandoned antimicrobial discovery and development given their high costs and low yield. Against this backdrop, international and cross-disciplinary collaboration appears to be taking root in earnest, although specific strategies still need defining. Educational programs targeting both antimicrobial prescribers and consumers must be further developed and supported. The general public must continue to be made aware of the current scale of AMR's threat, and must perceive antimicrobials as they are: a non-renewable and endangered resource.
Infection Control Programme and WHO Collaborating Centre on Patient Safety, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Angela
A
Huttner
Infection Control Programme and WHO Collaborating Centre on Patient Safety, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Stephan
S
Harbarth
Fondation Hôpital St Joseph, Paris, France.
Jean
J
Carlet
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sara
S
Cosgrove
Department of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium.
Herman
H
Goossens
Department of Infectious Diseases and Immunity, Imperial College London, The Centre for Infection Prevention and Management, London, UK.
Alison
A
Holmes
Laboratory of Bacteriology-Hygiene, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie-Paris 6, Paris, France.
Vincent
V
Jarlier
Department of Medical Microbiology and Infection Control, Radboud University Nijmegen Medical Centre and Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Andreas
A
Voss
Infection Control Programme and WHO Collaborating Centre on Patient Safety, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Didier
D
Pittet
Animal medicine; Antibiotic stewardship; Antimicrobial conservation; Antimicrobial resistance; Care bundles; Environment; Global health; Hand hygiene; Human medicine; Infection control; Regulations; Surveillance networks; World Healthcare-Associated Infections Forum