Ocular metastasis of lung adenocarcinoma with ELM4-ALK translocation: A case report with a review of the literature.
Choroidal metastasis is the most common intraocular neoplasm and is associated with significant morbidity. In a small percentage of patients, ocular manifestation may be the initial presentation of a systemic malignancy and can be diagnostically difficult to distinguish from ocular primary malignancies. Herein, we present a case of a never-smoker whose ocular pathology was integral to the diagnosis and management of a lung adenocarcinoma harboring a rare oncogene. Through this case, we have explored important diagnostic and therapeutic considerations of pulmonary metastases to the choroid.
Department of Ophthalmology, University of Ottawa, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada ; Department of Pathology and Laboratory Medicine, University of Ottawa, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Kailun
K
Jiang
Seymour
S
Brownstein
Harmanjatinder S
HS
Sekhon
Scott A
SA
Laurie
Kay
K
Lam
Steven
S
Gilberg
William
W
Britton
Adenocarcinoma; Choroidal metastasis; Crizotinib; EML4-ALK translocation; Non-small cell lung carcinoma; Targeted therapy