Carbapenem de-escalation therapy in a resource-limited setting.
Pulmonary infection (P=.01) and an infectious diseases consultation (P=.04) were associated with carbapenem de-escalation; pulmonary infection and septic shock were associated with unsuccessful de-escalation. Successful de-escalation was associated with lower mortality (0% vs 23%; P<.001) and shorter duration of carbapenem use (4 vs 10 days; P ≤ .001).
Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand.
Anucha
A
Apisarnthanarak
Nuntanij
N
Bhooanusas
Apiwat
A
Yaprasert
Linda M
LM
Mundy
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D005260:Female; D005840:Gentian Violet; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010619:Phenazines; D012017:Referral and Consultation; D012772:Shock, Septic / Q000188:drug therapy; D013785:Thailand; D014552:Urinary Tract Infections / Q000188:drug therapy; D055815:Young Adult
D000900:Anti-Bacterial Agents; D015780:Carbapenems; C035863:Gram's stain; D010619:Phenazines; D005840:Gentian Violet