The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma.
The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.
School of Medicine; Chung Shan Medical University; Taichung, Taiwan ; Institute of Medicine; Chung Shan Medical University; Taichung, Taiwan.
Wen-Wei
WW
Sung
Huei
H
Lee
CIP2A; HPV; IL-10; IL-10R; lung cancer