The presence of antibodies against the AD2 epitope of cytomegalovirus glycoprotein B is associated with acute rejection after renal transplantation.
The aim of this study was to evaluate the association between antibodies against cytomegalovirus (CMV) glycoprotein B (gB) and acute rejection after transplantation. Seventy-seven consecutive renal transplant recipients in a D + /R+ setting were studied. Biopsy-proven rejection occurred in 35% of the recipients. Among these recipients, 85% had antibodies against CMV gB. The rate of acute rejection was significantly higher in recipients with antibodies against gB than in those without them. Antibodies against gB can be a useful predictor of acute rejection in renal transplant recipients in a D + /R+ setting.
Department of Urology; Department of Microbiology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295.
Kei
K
Ishibashi
Tadahiko
T
Tokumoto
Hiroki
H
Shirakawa
Toshiki
T
Oguro
Tomohiko
T
Yanagida
Norio
N
Takahashi
Masanori
M
Nomiya
Nobuhiro
N
Haga
Ken
K
Aikawa
Kazunari
K
Tanabe
Naoki
N
Inoue
Yoshiyuki
Y
Kojima
Tatsuo
T
Suzutani
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus
acute rejection; cytomegalovirus; glycoprotein B; renal transplantation