Multifunctional core-shell structured nanocarriers for synchronous tumor diagnosis and treatment in vivo.
Multifunctional, mesoporous, silica-coated upconversion luminescent/magnetic NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase-transfer-assisted surfactant-templating coating process, followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof-of-principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (P.R. China); University of the Chinese Academy of Sciences, Beijing 100049 (P.R. China).
Yin-Yin
YY
Chen
Ping-An
PA
Ma
Dong-Mei
DM
Yang
Yuan
Y
Wu
Yun-Lu
YL
Dai
Chun-Xia
CX
Li
Jun
J
Lin
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D004871:Erbium / Q000737:chemistry; D005459:Fluorides / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D015018:Ytterbium / Q000737:chemistry
D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D011092:Polyethylene Glycols; D004871:Erbium; D004317:Doxorubicin; D005682:Gadolinium; D015018:Ytterbium; D005459:Fluorides
imaging agents; luminescence; magnetic properties; medicinal chemistry; nanostructures