Carbon-based drug delivery carriers for cancer therapy.
In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.
Dong-Jin
DJ
Lim
Myeongbu
M
Sim
Leeseul
L
Oh
Kyunghee
K
Lim
Hansoo
H
Park
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D058612:Nanodiamonds / Q000737:chemistry*; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods
D000970:Antineoplastic Agents; D004337:Drug Carriers; D058612:Nanodiamonds; D037742:Nanotubes, Carbon; D006108:Graphite