Intense pulsed light may improve inflammatory acne through TNF-α down-regulation.
BACKGROUND
Despite many studies on the action of yellow light in acne, its efficacy and mechanisms of action are still unclear.


OBJECTIVE
To determine if IPL can cause a clinical improvement in acne and whether it modifies TLR2 and TNFα expression.


METHODS
Twenty-one patients with mild to moderate acne involving their backs received 530 nm IPL treatments once every 2 weeks. Assessments at baseline and after the fourth treatment included lesion counts, Leeds grading and SER. Biopsies from the treatment area were taken at three time points. TLR2 expression was determined using immunohistochemistry, and TaqMan Low Density Arrays were used to measure TNFα, IL-8 and IL-10.


RESULTS
Inflamed lesion counts fell significantly by 28.0% (p = 0.002) but not the Leeds score, SER or non-inflamed lesions. A reduction in TNFα expression of 17.6% (p = 0.031) weakly correlated with the change in lesion counts. TLR2 expression fell by 2.6% (p < 0.001) but did not correlate with lesion counts. Neither IL-10 nor IL-8 expression was significantly altered.


CONCLUSIONS
530 nm IPL significantly reduces inflammatory lesions, where its efficacy will need optimising to make it a viable treatment option. Its mechanism seems to include a novel anti-TNFα effect, independent of IL-10 up-regulation.
Department of Dermatology, Cardiff University , Cardiff , UK.
Marisa
M
Taylor
Rebecca
R
Porter
Maria
M
Gonzalez
D000152:Acne Vulgaris; D000328:Adult; D001415:Back; D003357:Cosmetic Techniques; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D062325:Intense Pulsed Light Therapy / Q000379:methods*; D007378:Interleukins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007378:Interleukins; D051195:Toll-Like Receptor 2; D014409:Tumor Necrosis Factor-alpha