Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy.
TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
College of Pharmacy, Ewha Womans University, Seoul 120-750.
Yhun Yhong
YY
Sheen
Min-Jin
MJ
Kim
Sang-A
SA
Park
So-Yeon
SY
Park
Jeong-Seok
JS
Nam
ALK5; Breast cancer; EW-7197; Metastasis; Transforming growth factor-β (TGF-β)