Evaluation and comparison of zinc absorption level from 2-Alkyle 3-Hydroxy pyranon-zinc complexes and zinc sulfate in rat in vivo.
BACKGROUND
Although zinc sulfate has been used to improve disorders originated from zinc deficiency, its low compliance is due to gastrointestinal complications; therefore, other zinc compounds have been suggested as replacers for zinc deficient people. The objective of this study was to evaluate and compare the absorption of ethyl and methyl zinc-maltol with that of zinc sulfate to substitute zinc sulfate with those complexes.


METHODS
After five weeks of being fed by zinc deficient food, zinc deficient rats were divided into four groups randomly receiving medicinal solutions of zinc sulfate, zinc ethyl maltol and zinc methyl maltol using feeding tube method for two weeks while the control was received distilled water. Serum zinc concentration and ALP (Alkaline Phosphatase) and LDH (Lactate Dehydrogenase) activity of rats were determined before and after the study. Statistical analyses were performed using SPSS 11.5. The study was conducted from 2008 to 2010.


RESULTS
Serum zinc concentration and enzyme activity in all groups receiving drug solution increased. The most and least increase were in zinc sulfate and zinc methyl maltol groups, respectively. The difference between zinc methyl maltol and zinc sulfate group was significant (P < 0.05); however, this difference was not significant in the case of zinc ethyl maltol.


CONCLUSIONS
Zinc ethyl maltol can be a suitable and preferable substitute for zinc sulfate.
Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Science, Isfahan, Iran.
Badii
B
Akbar
Nekouei
N
Niloufar
Mostafavi
M
Abolfazl
Saghaei
S
Lofollah
Khodarahmi Qadam
KQ
Ali
Valadian
V
Soheyla
Alkaline phosphatase; Lactate dehydrogenase; zinc ethyl maltol; zinc intestinal absorption; zinc methyl maltol; zinc sulfate