Toll-like receptor 4 gene polymorphisms and acute coronary syndrome: no association in a Mexican population.
OBJECTIVE
The objective of this study was to establish the role of the TLR-4 gene polymorphisms in individuals in risk of developing ACS.


METHODS
The study included 457 Mexican patients with ACS and 283 control individuals. The TLR-4 Asp299Gly and TLR-4 Thr399Ile single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays on an 7900HT Fast real-time PCR system according to manufacturer's instructions (Applied Biosystems, Foster City, USA).


RESULTS
The results obtained in this study showed that the frequency of the two polymorphisms (TLR-4 Asp299Gly and TLR-4 Thr399Ile) studied were similar between patients with ACS and healthy controls. Multiple logistic regression analysis showed that the largest risk factor for ACS development was given by smoking (11.88-fold increased risk), hypertension (4.32-fold increased risk), type II diabetes (3.44-fold increased risk), gender (2.32-fold increased risk), and dyslipidemia (1.52-fold increased risk).


CONCLUSIONS
The Asp299Gly and Thr399Ile polymorphisms were not associated with susceptibility to ACS in the Mexican population.
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Marco A
MA
Martínez-Ríos
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Gilberto
G
Vargas-Alarcón
Department of Sociomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Maite
M
Vallejo
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Erick
E
Cruz-Martínez
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Oscar
O
Pérez-Méndez
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Ángel
Á
Medina-Andrade
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Mónica
M
De la Torre-García
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Marco A
MA
Peña-Duque
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: mfragoso1275@yahoo.com.mx.
José Manuel
JM
Fragoso
D054058:Acute Coronary Syndrome / Q000235:genetics*; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics*
D051197:Toll-Like Receptor 4
Acute coronary syndrome; Genetics; Genética; Mexico; México; Polimorfismos de un nucleótido; Single nucleotide polymorphisms; Síndrome coronario agudo