Transdisciplinary approach to restore pancreatic islet function.
The focus of our research is on islet immunobiology. We are exploring novel strategies that could be of assistance in the treatment and prevention of type 1 diabetes, as well as in the restoration of metabolic control via transplantation of insulin producing cells (i.e., islet cells). The multiple facets of diabetes and β-cell replacement encompass different complementary disciplines, such as immunology, cell biology, pharmacology, and bioengineering, among others. Through their interaction and integration, a transdisciplinary dimension is needed in order to address and overcome all aspects of the complex puzzle toward a successful clinical translation of a biological cure for diabetes.
Carmen
C
Fotino
R Damaris
RD
Molano
Camillo
C
Ricordi
Antonello
A
Pileggi
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D060833:Cellular Microenvironment; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000378:metabolism / Q000637:transplantation; D007515:Islets of Langerhans / Q000276:immunology* / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000379:methods; D015398:Signal Transduction
D000255:Adenosine Triphosphate