Serum 25(OH)D and lipid levels in Chinese obese and normal weight males before and after oral vitamin D supplementation.
OBJECTIVE
To study the effect of oral vitamin D (VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men.


METHODS
Twenty-one obese men with their body mass index (BMI)>28 kg/m(2) served as an obese group and 22 healthy normal-weight men with their BMI<24 kg/m(2) served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25(OH)D] concentration was measured with an enzyme-immunoassay kit.


RESULTS
After oral VD supplementation, the serum 25(OH)D concentration significantly increased from 46.1±9.1 nmol/L to 116.7±20.3 nmol/L in the obese subjects (P<0.01) and from 52.8±17.8 nmol/L to 181.3±30.2 nmol/L in the control ones (P=0.13). The serum high-density lipoprotein cholesterol (HDL-C) level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids (triglycerides, total cholesterol, and low-density lipoprotein cholesterol) in either of the two groups.


CONCLUSIONS
The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
Molecular Biology Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen 518020, Guangdong, China.
Ji Chang
JC
Zhou
Yu Mei
YM
Zhu
Ping
P
Guo
Zheng
Z
Chen
Feng Zhu
FZ
Xie
Xiao Li
XL
Liu
Shan
S
He
D015992:Body Mass Index; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
D014807:Vitamin D
Obesity; Serum 25(OH)D; Serum lipid; Vitamin D