Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells.
Transient receptor potential vanilloid 2 (TRPV2), a nonselective cation channel, has become an attractive target gene for tumor studies due to its wide range of physiological and pathological functions. However, its specific role in bladder cancer development and progression remains unclear. The aim of the present study was to investigate the effects of TRPV2 on the proliferation, migration and invasion of 5637 bladder cancer cellsin vitro. Rat TRPV2 cDNA was transfected into 5637 bladder cancer cells and changes in the behavior of the cells were detected. It was observed that TRPV2 enhanced bladder cancer cell migration and invasion; however, it did not affect cell proliferationin vitro. TRPV2 activity, which may be mediated by direct matrix metalloproteinase 2 (MMP2) regulation, is important in bladder tumor development and progression. The results of this study suggest that TRPV2 channels are a potential therapeutic target for bladder carcinoma.
Department of Urology Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
Quanliang
Q
Liu
Xinghuan
X
Wang
bladder carcinoma; matrix metalloproteinase 2; migration; proliferation; transient receptor potential channels