Antidiabetic and Beta cell-protection activities of purple corn anthocyanins.
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
Department of Biochemistry, College of Medicine, Hallym University ; FrontBio Inc., Chuncheon 200-702, ; Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea.
Su Hee
SH
Hong
Jee-In
JI
Heo
Jeong-Hyeon
JH
Kim
Sang-Oh
SO
Kwon
Kyung-Mok
KM
Yeo
Anna M
AM
Bakowska-Barczak
Paul
P
Kolodziejczyk
Ok-Hyun
OH
Ryu
Moon-Ki
MK
Choi
Young-Hee
YH
Kang
Soon Sung
SS
Lim
Hong-Won
HW
Suh
Sung-Oh
SO
Huh
Jae-Yong
JY
Lee
Antidiabetes; Antihyperglycemic activity; Beta cell-protection; Pancreatic beta cell; Purple corn anthocyanins; db/db Mice