Type-II histone deacetylases: elusive plant nuclear signal transducers.
Since the beginning of the 21st century, numerous studies have concluded that the plant cell nucleus is one of the cellular compartments that define the specificity of the cellular response to an external stimulus or to a specific developmental stage. To that purpose, the nucleus contains all the enzymatic machinery required to carry out a wide variety of nuclear protein post-translational modifications (PTMs), which play an important role in signal transduction pathways leading to the modulation of specific sets of genes. PTMs include protein (de)acetylation which is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Regarding protein deacetylation, plants are of particular interest: in addition to the RPD3-HDA1 and Sir2 HDAC families that they share with other eukaryotic organisms, plants have developed a specific family called type-II HDACs (HD2s). Interestingly, these HD2s are well conserved in plants and control fundamental biological processes such as seed germination, flowering or the response to pathogens. The aim of this review was to summarize current knowledge regarding this fascinating, but still poorly understood nuclear protein family.
Pôle Mécanisme et Gestion des Interactions Plantes-microorganismes - ERL CNRS 6300, Université de Bourgogne, UMR 1347 Agroécologie, 17 rue Sully, BP 86510, Dijon cedex, 21065, France.
Vincent
V
Grandperret
Valérie
V
Nicolas-Francès
David
D
Wendehenne
Stéphane
S
Bourque
D000595:Amino Acid Sequence; D002467:Cell Nucleus / Q000378:metabolism*; D017124:Conserved Sequence; D006655:Histone Deacetylases / Q000737:chemistry / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D015398:Signal Transduction; D013312:Stress, Physiological
D010940:Plant Proteins; D006655:Histone Deacetylases
nucleus; post-translational modifications; signal transduction