Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.
This study examined the associations between pesticide exposure, genetic polymorphisms for
quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.
a Department of Epidemiology and Public Health , University of Maryland School of Medicine , Baltimore , Maryland , USA.
Sania
S
Amr
Rebecca
R
Dawson
Doa'a A
DA
Saleh
Laurence S
LS
Magder
Diane Marie
DM
St George
Mai
M
El-Daly
Katherine
K
Squibb
Nabiel N
NN
Mikhail
Mohamed
M
Abdel-Hamid
Hussein
H
Khaled
Christopher A
CA
Loffredo
D000328:Adult; D000368:Aged; D000382:Agricultural Workers' Diseases / Q000453:epidemiology / Q000235:genetics; D000383:Agriculture / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004534:Egypt; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D010575:Pesticides / Q000633:toxicity*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics*
D010575:Pesticides; C441642:SOD3 protein, human; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human
Egypt; agricultural workers; bladder cancer; epidemiology; gene polymorphism; pesticides