Sporothrix schenckii lymphadentitis in a male with X-linked chronic granulomatous disease.
Sporothrix schenckii lymphadenitis was identified in a 33 month old male with X-linked chronic granulomatous disease (CGD). S. schenckii is a dimorphic catalase producing fungus found in the soil of temperate and tropical climates. Host defense against S. schenckii relies primarily on innate and cellular responses and gp91(phox-/-) mice are susceptible to disseminated infection. This case represents the first report of susceptibility to sporotrichosis in a patient with CGD.
Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Children's Research Institute, University of South Florida, 140-7th Avenue South, Box 7890, St. Petersburg, FL, 33701, USA.
Jessica R
JR
Trotter
Panida
P
Sriaroon
David
D
Berman
Aleksandra
A
Petrovic
Jennifer W
JW
Leiding
D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D008297:Male; D009333:Neck / Q000473:pathology; D013175:Sporothrix; D013174:Sporotrichosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D000935:Antifungal Agents