Role of the microbiota and antibiotics in primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Sreet SW, Rochester, MN 55905, USA.
James H
JH
Tabibian
Jayant A
JA
Talwalkar
Keith D
KD
Lindor
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D064307:Microbiota
D000900:Anti-Bacterial Agents