[Effect of flavonoids from hedysari radix on pulmonary functions of pulmonary fibrosis rat].
OBJECTIVE
To study the effect of flavonoids from Hedysari Radix on pulmonary functions of pulmonary fibrosis rat and its mechanism.


METHODS
72 Wistar rats were randomly divided into 6 groups: blank control group, model group, prednisone group, Hedysari Radix flavonoids low, medium and high dosage group. The rat model was established by propelling bleomycin into bronchial tree through endotracheal intubation with laryngoscope. The pulmonary fanctions were measured.


RESULTS
Hedysari Radix flavonoids could normalize the pulmonary functions of rats with bleomycin-induced pulmonary fibrosis.


CONCLUSIONS
Hedysari Radix flavonoids can inhibit the process of pulmonary fibrosis.
Gansu University of TCM, Lanzhou 730000, China. gslijuan@sina.com
Juan
J
Li
Xing-Yao
XY
Lin
Jin-Tian
JT
Li
Yi
Y
Zhang
Xue-Yan
XY
Li
Yong-Qi
YQ
Liu
Ming
M
Jing
Shao-Bo
SB
Sun
Yun
Y
Su
Guang-Wei
GW
Liu
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D005541:Forced Expiratory Volume / Q000502:physiology; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008170:Lung Compliance / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D001761:Bleomycin; D011241:Prednisone