IRF4 provides rations for cytotoxic CD8(+) T cell soldiers.
The transcription factor IRF4 is known to be essential for differentiation of effector CD4(+) T cell subsets. In this issue, Yao et al. (2013) identify IRF4 as a regulator of checkpoints in the final steps and maintenance of CD8(+) T cell effector differentiation.
Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, 35043 Marburg, Germany.
Magdalena
M
Huber
Michael
M
Lohoff
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology*; D050835:Interferon Regulatory Factors / Q000502:physiology*; D000099218:Interferon Regulatory Factor-4
D050835:Interferon Regulatory Factors; D000099218:Interferon Regulatory Factor-4