Biological variations of some analytes in renal posttransplant patients: a different way to assess routine parameters.
BACKGROUND
Biological variation (BV) data of analytes have been used to evaluate the significant changes in serial results (reference change value, RCV) of healthy individuals in clinical laboratories. However, BV data of healthy subjects may not be identical to the analytes of patients with ongoing clinical condition. The aim of this study was to calculate intra-(CVw) (coefficient of variation for intra-individual BV) and inter-individual (CVg) BV, index of individuality, and RCV of nine serum analytes of renal posttransplant patients.


METHODS
Six serum specimens were obtained in an interval of two months in a one-year period from 70 transplant patients who had been stable for three years. Each time creatinine, uric acid, urea, sodium, potassium, calcium, inorganic phosphate, total protein, and albumin of these patients were analyzed with an integrated clinical chemistry/immunoassay auto-analyzer. ANOVA tests were used to calculate the variations. Results were compared with the data of healthy subjects obtained from BV database.


RESULTS
CVw of all nine analytes of the renal transplant patients were higher than the healthy subjects. RCVs of these analytes were calculated as 14.5% for creatinine, 16.5% for urea, 13.7% for urate, 12.57% for albumin, 8.26% for total protein, 3.25% for sodium, 12.81% for potassium, 5.88% for calcium, and 21.57% for inorganic phosphate.


CONCLUSIONS
RCV concept for predicting the clinical status in posttransplant population represents an optimization of laboratory reporting and could be a valuable tool for clinical decision.
Department of Clinical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey; Cukurova University, Balcali Hospital, Central Laboratory, Adana, Turkey.
Ozlem Goruroglu
OG
Ozturk
Saime
S
Paydas
Mustafa
M
Balal
Gulhan
G
Sahin
Esin Damla Ziyanoglu
ED
Karacor
Sedefgul Yuzbasioglu
SY
Ariyurek
Akgun
A
Yaman
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D001774:Blood Chemical Analysis / Q000592:standards*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D015415:Biomarkers
analytical variation; index of individuality; intra-individual BV; reference change value; renal transplantation