Localization of the α2-macroglobulin gene and Lpm gene family on mink chromosome 9.
Using cloned cDNA for human α2-macroglobulin (A2M) as a probe, mink-Chinese hamster hybrid cells were analysed. The results allowed us to assign a gene for A2M to mink chromosome 9. Breeding tests demonstrated that the Lpm-locus coding for other related α-macroglobulin protein and the gene for peptidase B (PEPB) are linked 11±3 cm apart. The PEPB gene is located on mink chromosome 9, and hence, the Lpw-locus is on the same mink chromosome. The relationship of the genetic systems controlling the isotypically different α-macroglobulins in mink serum are discussed.
Siberian Division, Institute of Cytology and Genetics, Academy of Sciences of the USSR, 630090, Novosibirsk-90, USSR.
V I
VI
Yermolaev
G I
GI
Karasik
T M
TM
Khlebodarova
N M
NM
Matveeva
M R
MR
Mullakandov
A M
AM
Nayakschin
T V
TV
Shumny
N B
NB
Rubtsov
O L
OL
Serov
O K
OK
Baranov