C-reactive protein predicts 96-week carotid intima media thickness progression in HIV-infected adults naive to antiretroviral therapy.
: This is a 96-week prospective cohort study of antiretroviral therapy (ART)-naive HIV-infected adults and matched healthy controls to assess progression of carotid intima media thickness (CIMT) and its relationship to inflammation. Median common carotid artery (CCA) CIMT increased significantly but similarly in both groups [CCA: 0.02 (interquartile range: 0-0.05); P < 0.01 within HIV-infected adults vs. 0.01 (0-0.05) mm; P < 0.01 within controls; and P = 0.83 between groups]. Change in bulb CIMT yielded similar results. Independent predictors of CCA CIMT progression in HIV-infected adults were higher systolic blood pressure, total cholesterol, and high sensitivity C-reactive protein. Independent predictors of bulb CIMT progression were higher non-high-density lipoprotein cholesterol and high sensitivity C-reactive protein. Other inflammation markers were not associated with CIMT progression.
*Case Western Reserve University School of Medicine, Cleveland, OH; †Department of Medicine, Division of Infectious Disease, MetroHealth Medical Center, Cleveland, OH; ‡Department of Medicine, Division of Cardiovascular Medicine, University Hospitals Harrington Heart and Vascular Institute, Cleveland, OH; and §Department of Pediatrics, Division of Infectious Disease, University Hospitals Case Medical Center, Cleveland, OH.
Corrilynn O
CO
Hileman
Chris T
CT
Longenecker
Teresa L
TL
Carman
Grace A
GA
McComsey
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D017536:Carotid Artery, Common / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D008078:Cholesterol, LDL; D002097:C-Reactive Protein