[The significance of beta-receptor expression in infantile hemangiomas].
OBJECTIVE
To investigate the expression and significance of beta-receptor ( p-R) in infantile hemangioma.


METHODS
The expression of beta-R was detected by immunohistochemistry in infantile hemangioma (40 cases), venous malformation (20 cases) and normal skin (10 cases).


RESULTS
The positive expression rate of beta2-R was 70% (28/40) in infantile hemangioma, while no expression of beta2-R in venous malformation and normal skin. Among 28 cases with positive expression of beta2-R, 24 cases were in proliferative phase. The positive expression of beta2-R in infantile hemangioma was significantly higher than that in venous malformation and normal skin tissue. The positive expression of beta2-R in the proliferative hemangioma and non-proliferative hemangioma was also significantly different (P < 0.05).


CONCLUSIONS
beta2-R is specifically expressed in infantile hemangioma, especially in proliferative hemangioma.
Department of Plastic Surgery, Union Hospital, Tongli Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
Jing
J
Li
Xiao-Dan
XD
Li
Yu
Y
Cai
Jia-Feng
JF
Liu
Hui
H
Liu
Zhe-Yuan
ZY
Zhao
D016022:Case-Control Studies; D005260:Female; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta