UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks.
Unified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350,000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations.
Centre for Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal and Institute for Theoretical Biology, Charité, Humboldt-University, Berlin, Germany.
Ravi Kiran Reddy
RK
Kalathur
José Pedro
JP
Pinto
Miguel A
MA
Hernández-Prieto
Rui S R
RS
Machado
Dulce
D
Almeida
Gautam
G
Chaurasia
Matthias E
ME
Futschik
D030562:Databases, Protein; D004194:Disease; D015870:Gene Expression; D005796:Genes; D023281:Genomics; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010641:Phenotype; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D004364:Pharmaceutical Preparations; D011506:Proteins