Does experience in talking facilitate speech repetition?
Speech is unique among highly skilled human behaviors in its ease of acquisition by virtually all individuals who have normal hearing and cognitive ability. Vocal imitation is essential for acquiring speech, and it is an important element of social communication. The extent to which age-related changes in cognitive and motor function affect the ability to imitate speech is poorly understood. We analyzed the distributions of response times (RT) for repeating real words and pseudowords during fMRI. The average RT for older and younger participants was not different. In contrast, detailed analysis of RT distributions revealed age-dependent differences that were associated with changes in the time course of the BOLD response and specific patterns of regional activation. RT-dependent activity was observed in the bilateral posterior cingulate, supplementary motor area, and corpus callosum. This approach provides unique insight into the mechanisms associated with changes in speech production with aging.
Department of Speech Pathology and Audiology, 805 Allen Hall, West Virginia University, Morgantown, WV 26506, USA; Center for Advanced Imaging, 805 Allen Hall, West Virginia University, Morgantown, WV 26506, USA. Electronic address: shusterl@gvsu.edu.
Linda I
LI
Shuster
Department of Speech Pathology and Audiology, 805 Allen Hall, West Virginia University, Morgantown, WV 26506, USA. Electronic address: moore.2492@buckeyemail.osu.edu.
Donna R
DR
Moore
Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: gangchen@mail.nih.gov.
Gang
G
Chen
Department of Speech Pathology and Audiology, 805 Allen Hall, West Virginia University, Morgantown, WV 26506, USA. Electronic address: Dennis.Ruscello@mail.wvu.edu.
Dennis M
DM
Ruscello
Department of Biochemistry, 1 Medical Center Drive, P.O. Box 9142, West Virginia University, Morgantown, WV 26506, USA. Electronic address: wwonderlin@hsc.wvu.edu.
William F
WF
Wonderlin
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007100:Imitative Behavior / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D013060:Speech / Q000502:physiology*; D055815:Young Adult