(α'(H))-Dicalcium silicate bone cement doped with tricalcium phosphate: characterization, bioactivity and biocompatibility.
The influence of phosphorus doping on the properties of (α'(H))-dicalcium silicate (C(2)S) bone cement was analyzed, in addition to bioactivity and biocompatibility. All the cements were composed of a solid solution of TCP in C(2)S ([Formula: see text]-C(2)S(ss)) as the only phase present. The compressive strength ranged from 3.8-16.3 MPa. Final setting times ranged from 10 to 50 min and were lower for cements with lower L/P content. Calcium silicate hydrate was the principal phase formed during the hydration process of the cements. The cement exhibited a moderate degradation and could induce carbonated hydroxyapatite formation on its surface and into the pores. The cell attachment test showed that the (α'(H))-C(2)SiO(4) solid solution supported human adipose stem cells adhesion and spreading, and the cells established close contacts with the cement after 24 h of culture. The novel (α'(H))-C(2)S(ss) cements might be suitable for potential applications in the biomedical field, preferentially as materials for bone/dental repair.
Instituto de Bioingeniería, Universidad Miguel Hernández, Avda. de la Universidad s/n, 03202, Elche, Alicante, Spain, piedad@umh.es.
Piedad N
PN
de Aza
Fausto
F
Zuleta
Pablo
P
Velasquez
Nestor
N
Vicente-Salar
Juan A
JA
Reig
D000273:Adipose Tissue / Q000166:cytology; D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds / Q000737:chemistry / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D017640:Silicates / Q000737:chemistry / Q000494:pharmacology*; D013234:Stem Cells / Q000166:cytology; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds; D002130:Calcium Phosphates; D017640:Silicates; C013481:dicalcium silicate; C018392:tricalcium phosphate