Nucleopalladation triggering the oxidative Heck reaction: a general strategy to diverse β-indole ketones.
A simple and efficient palladium-catalyzed oxidative coupling between 2-alkynyl anilines and allylic alcohols is described by using cheap and green dioxygen as the oxidant. These cross-couplings have a large functional group tolerance and are of higher reactivity toward electron nonbaised allylic alcohols. The resultant β-indole ketones are readily converted to pharmaceutically significant β-indole alcohol/amine and pyrrolo[2,1-a]isoquinolines.
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
Qian
Q
Wang
Liangbin
L
Huang
Xia
X
Wu
Huanfeng
H
Jiang