Lean mass as a predictor of bone density and microarchitecture in adult obese individuals with metabolic syndrome.
The effects of obesity and metabolic syndrome (MS) on bone health are controversial. Furthermore, the relationship between body composition and bone quality has not yet been determined in this context. The aim of this study was to investigate the correlations between body composition and bone mineral density (BMD) and bone microstructure in obese individuals with MS. This cross-sectional study assessed 50 obese individuals with MS with respect to their body composition and BMD, both assessed using dual X-ray absorptiometry, and bone microarchitecture, assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) of the distal tibia and radius. Several HR-pQCT measurements exhibited statistically significant correlations with lean mass. Lean mass was positively correlated with parameters of better bone quality (r: 0.316-0.470) and negatively correlated with parameters of greater bone fragility (r: -0.460 to -0.310). Positive correlations were also observed between lean mass and BMD of the total femur and radius 33%. Fat mass was not significantly correlated with BMD or any HR-pQCT measurements. Our data suggest that lean mass might be a predictor of bone health in obese individuals with MS.
Postgraduate Programme in Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: dudamadeira@gmail.com.
Eduardo
E
Madeira
Postgraduate Programme in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: tmafort@gmail.com.
Thiago Thomaz
TT
Mafort
Postgraduate Programme in Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: miguelmadeira@cremerj.org.br.
Miguel
M
Madeira
Endocrinology Department, The Capriglione Luiz State Institute of Diabetes and Endocrinology, Rio de Janeiro, RJ, Brazil. Electronic address: erikaguedes@rjnet.com.br.
Erika Paniago
EP
Guedes
Endocrinology Department, The Capriglione Luiz State Institute of Diabetes and Endocrinology, Rio de Janeiro, RJ, Brazil. Electronic address: rom_br@yahoo.com.
Rodrigo Oliveira
RO
Moreira
Rheumatology Department, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: laura.mendonca@uol.com.br.
Laura Maria Carvalho
LM
de Mendonça
PhD. COPPE, Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: inayacorrea@gmail.com.
Inayá Correa Barbosa
IC
Lima
Postgraduate Programme in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: pinho@cmb.com.br.
Paulo Roberto Alves
PR
de Pinho
Postgraduate Programme in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: phel.lop@uol.com.br.
Agnaldo José
AJ
Lopes
Postgraduate Programme in Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: fleiuss@hucff.ufrj.br.
Maria Lucia Fleiuss
ML
Farias
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D001823:Body Composition; D015519:Bone Density; D001842:Bone and Bones / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D009929:Organ Size; D014057:Tomography, X-Ray Computed
BMD; BMI; BV/TV; Body composition; Bone microarchitecture; Bone mineral density; C-reactive protein; CRP; CTX; CTh; DXA; Dcort; Dtot; Dtrab; HR-pQCT; High-resolution peripheral quantitative computed tomography; MS; Metabolic syndrome; Obesity; PTH; TbN; TbSp; TbSp 1/N SD; TbTh; body mass index; bone mineral density; carboxy-terminal telopeptide of collagen-1; cortical thickness; dual-energy X-ray absorptiometry; high-resolution peripheral quantitative computed tomography; metabolic syndrome; parathormone; percentage of trabecular bone volume; standard deviation of trabecular spacing; trabecular number; trabecular separation; trabecular thickness; volumetric BMD of cortical bone; volumetric BMD of total bone; volumetric BMD of trabecular bone