Major hepatectomy is a safe modality for the treatment of intrahepatic cholangiocarcinoma in selected patients complicated with cirrhosis.
OBJECTIVE
The objective of this paper is to evaluate the perioperative outcomes of major hepatectomy for intrahepatic cholangiocarcinoma (ICC) in patients with cirrhosis.


METHODS
We retrospectively evaluated the preoperative, intraoperative, and postoperative findings in 42 consecutive patients with cirrhosis and in 102 patients with normal livers who underwent major hepatectomy for ICC.


RESULTS
Preoperative liver function was worse in patients with cirrhosis compared to patients without cirrhosis. Cirrhotic patients had significantly higher intraoperative blood loss, longer operation time, and longer hospital stay than non-cirrhotic patients. However, the two groups had similar overall morbidity and hospital mortality rates and similar rates of liver failure or other complications. Their R0 resection rates, resection margin widths and disease-free survival rates were also similar.


CONCLUSIONS
Major hepatectomy for ICC can be performed in selected cirrhotic patients with acceptable morbidity and mortality rates, as compared to patients without cirrhosis.
Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, No.253 of Jiefang Road, Changsha, 410002, People's Republic of China.
Hao
H
Li
Jin-shu
JS
Wu
Xin-tian
XT
Wang
Pin
P
Lv
Gang
G
Liu
Bu-ning
BN
Tian
Ya-yong
YY
Li
Dao-jin
DJ
Chen
Bo
B
Jiang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000150:complications / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D016063:Blood Loss, Surgical; D018281:Cholangiocarcinoma / Q000150:complications / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D018365:Neoplasm, Residual; D061646:Operative Time; D012189:Retrospective Studies; D015996:Survival Rate