The capability of quantum dots in crossing the placental barrier and the potential influence on erythrocytes.
Regarding the nanotoxicity, intense attention has been drawn on the capability of nanomaterials in crossing the biological barriers and their potential developmental toxicity. In the current study, the capability of quantum dots (QDs) in crossing the placental barrier and their potential biological influence on erythroid development were closely investigated. When administrated in mice, QDs tended to accumulate in liver, spleen and kidney, and revealed little capacity to cross the placental barrier. QDs had no effect on the survival of E14.5 fetal liver erythroid cells and erythropoiesis.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Zhe
Z
Wang
Shuping
S
Zhang
Guangbo
G
Qu
Sijin
S
Liu
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D008431:Maternal-Fetal Exchange; D051379:Mice; D008807:Mice, Inbred BALB C; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D045663:Quantum Dots