The anatomic- and clinical-based NERS (new risk stratification) score II to predict clinical outcomes after stenting unprotected left main coronary artery disease: results from a multicenter, prospective, registry study.
OBJECTIVE
The present study aimed to establish a risk score using a simple calculation with an enhanced predictive value for major adverse cardiac events (MACE) in patients with unprotected left main coronary artery (UPLMCA) disease after the implantation of a drug-eluting stent (DES).


BACKGROUND
The anatomic-, clinical-, and procedure-based NERS (New Risk Stratification) score was superior to the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) score in predicting MACE after stenting UPLMCA. The complexity of the calculation was its major limitation.


METHODS
The NERS score II was derived from our previous 2 studies and externally compared with the NERS and SYNTAX scores in 1,463 patients with UPLMCA disease who underwent implantation of a DES in a prospective, multicenter registry trial. The primary endpoint was MACE at 1 year after the index procedure, including myocardial infarction, cardiac death, and target vessel revascularization.


RESULTS
The NERS score II system consisted of 16 (7 clinical and 9 angiographic) variables. A NERS score II ≥19 demonstrated enhanced MACE sensitivity and specificity of 84.0% and 76.0% (MACE as the state variable), respectively, which were similar to the NERS score but significantly higher compared with the SYNTAX score. A NERS score II ≥19 was the only independent predictor of cumulative MACE (hazard ratio: 3.27; 95% confidence interval [CI]: 1.86 to 5.23; p ≤ 0.001) and stent thrombosis (odds ratio: 22.15; 95% CI: 12.47 to 57.92; p ≤ 0.001) at follow-up.


CONCLUSIONS
The NERS score II, similar to the conventional NERS score, is more predictive of MACE than the SYNTAX score in UPLMCA patients after implantation of a DES.
Cardiology Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: chmengx@126.com.
Shao-Liang
SL
Chen
Cardiology Department, Shenyang Northern Hospital, Shenyang, China. Electronic address: hanyaling@263.net.
Ya-Ling
YL
Han
Cardiology Department, Nanjing Heart Center, Nanjing, China.
Yao-Jun
YJ
Zhang
Cardiology Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Fei
F
Ye
Cardiology Department, Shenyang Northern Hospital, Shenyang, China.
Hai-Wei
HW
Liu
Cardiology Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jun-Jie
JJ
Zhang
Cardiology Department, Beijing Fuwai Hospital, Beijing, China.
Bo
B
Xu
Cardiology Department, Tianjin Armed Policemen Hospital, Tianjin, China.
Tie-Min
TM
Jiang
Cardiology Department, Beijing Anzhen Hospital, Beijing, China.
Yu-Jie
YJ
Zhou
Cardiology Department, Beijing Anzhen Hospital, Beijing, China.
Shu-Zheng
SZ
Lv
D000368:Aged; D016009:Chi-Square Distribution; D002681:China; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D003661:Decision Support Techniques; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D016017:Odds Ratio; D018579:Patient Selection; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
AUC; CABG; CI; CTO; DES; IVUS; LM; MACE; MI; NERS score; PCI; ROC; ST; SYNTAX score; TVR; UPLMCA; VD; area under the curve; chronic total occlusion; confidence interval; coronary artery bypass graft surgery; drug-eluting stent(s); eGFR; estimated glomerular filtration rate; intravascular ultrasound; left main coronary artery; major adverse cardiac event(s); myocardial infarction; percutaneous coronary intervention; prediction; receiver-operating characteristic; stent thrombosis; target vessel revascularization; unprotected left main coronary artery; unprotected left main coronary artery disease; vessel disease