Extranodal natural killer/T-cell lymphoma involving the gastrointestinal tract: analysis of clinical features and outcomes from the Asia Lymphoma Study Group.
BACKGROUND
The gastrointestinal (GI) tract is one of the most common extranasal sites in extranodal NK/T-cell lymphoma (ENKTL). However, data regarding ENKTL involving the GI tract are relatively scarce. Thus, we performed a multicenter, multinational retrospective study to analyze clinical features and treatment outcomes of ENKTL involving the GI tract.


METHODS
Patients with ENKTL involving the GI tract diagnosed in twelve participating centers between 1991 and 2012 were retrospectively analyzed from five Asian countries.


RESULTS
The analysis of 81 patients with ENKTL involving the GI tract revealed that more than 60% of patients presented as advanced disease with B symptoms. 55 patients (68%) had GI manifestations including abdominal pain (n = 26, 32%), GI tract bleeding (n = 17, 21%) and bowel perforation (n = 12, 15%). The most common GI site was the small intestine, including the jejunum and ileum (n = 57, 70.3%). There were 34 patients (42%) who received systemic chemotherapy while 33 patients (41%) underwent surgery plus chemotherapy. However, 35 patients (43%) died due to disease progression, and treatment-related mortality including sepsis occurred in 17 patients (21%). Thus, the median overall survival was 7.8 months (95% Confidence interval: 3.9 - 11.7 months). Patients who could undergo surgery plus chemotherapy showed a trend of better survival than those treated with chemotherapy alone.


CONCLUSIONS
Overall, the data indicated that ENKTL involving the GI tract has a dismal prognosis despite active treatment including chemotherapy and surgery. Thus, more effective treatment strategies are required for this disease entity.
Department of Medicine, Division of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. TongyuLim@hotmail.com.
Seok Jin
SJ
Kim
Hyun Ae
HA
Jung
Shih-Sung
SS
Chuang
Huangming
H
Hong
Cheng-Cheng
CC
Guo
Junning
J
Cao
Xiao-Nan
XN
Hong
Ritsuro
R
Suzuki
Hye Jin
HJ
Kang
Jong Ho
JH
Won
Wee-Joo
WJ
Chng
Yok-Lam
YL
Kwong
Cheolwon
C
Suh
Yu-Qin
YQ
Song
Jun
J
Zhu
Kevin
K
Tay
Soon Thye
ST
Lim
Junji
J
Suzumiya
Tong-Yu
TY
Lin
Won Seog
WS
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult