2-Methylenetetrahydropyrans: efficient partners in the carbonyl ene reaction.
The carbonyl ene reaction of 2-methylenetetrahydropyrans provides a rapid, high yielding route for the preparation of β-hydroxydihydropyrans under mild conditions. This process provides a new entry for the synthesis of 2-substituted tetrahydropyrans and for the direct introduction of oxygen heterocycles into molecular frameworks.
Department of Chemistry, Syracuse University , Syracuse, New York 13244, United States.
Guohua
G
Liang
Dakin T
DT
Sharum
Troy
T
Lam
Nancy I
NI
Totah
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000737:chemistry
D000447:Aldehydes; D002712:Chlorides; D007659:Ketones; D011714:Pyrans; D017967:Zinc Compounds; C016837:zinc chloride; D010100:Oxygen