Effect of flunixin meglumine or prostaglandin E2 treatment 15 days after breeding on fertility in Saanen does.
The objective of this study was to determine the effects of timely injections of flunixin meglumine (FM) or vaginal application of prostaglandin E2 (PgE2) on pregnancy, fertility, fecundity, and prolificacy rates in Saanen goats. One hundred and sixty-three nonlactating Saanen does were treated with a flugestone acetate (20 mg)-containing intravaginal sponge for 12 days. They also received eCG (400 IU) and a PGF2α analogue (50 μg) 10 days after progestagen priming. Does detected in estrus were mated and assigned randomly to one of three treatment groups. The PgE2 group (N = 40) received PgE2 (2.5 mg) intravaginally 15 days after mating. The FM group (N = 54) received flunixin meglumine (total dose, 100 mg) intramuscularly 15 days after mating. Flunixin meglumine was administered at 9:00 AM. Animals in the control group (N = 69) received no treatment. Pregnancy was diagnosed using transrectal ultrasonography (B-mode at 8 MHz) 30 days after mating. The pregnancy rate was significantly greater (P < 0.01) after 30 days in goats treated with PgE2 and also in the control group than in those treated with FM (67.5%, 59.4%, and 42.5%, respectively). The pregnancy rate did not differ between the PgE2 and the control group. The pregnancy and fertility rate were lowest in the FM group compared with the other groups. There was no significant difference in the prolificacy rate among experimental groups. In conclusion, our results showed that FM administration during a late luteal phase is detrimental to early pregnancy in goats.
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey. Electronic address: ycetin@mehmetakif.edu.tr.
Yunus
Y
Cetin
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey.
Mesih
M
Kocamuftuoglu
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Dicle, Diyarbakir, Turkey.
Nihat
N
Ozyurtlu
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Dicle, Diyarbakir, Turkey.
Ibrahim
I
Kucukaslan
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Yuzuncu Yil, Van, Turkey.
Sait
S
Sendag
Clinic for Obstetrics, Gynecology and Andrology, Justus-Liebig-University, Giessen, Germany.
Axel
A
Wehrend
D000818:Animals; D001947:Breeding / Q000379:methods*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D005298:Fertility; D006041:Goats / Q000502:physiology*; D008183:Luteal Phase; D011247:Pregnancy; D018873:Pregnancy Rate; D011448:Prostaglandin Antagonists / Q000494:pharmacology*
D011448:Prostaglandin Antagonists; C014558:flunixin meglumine; D015232:Dinoprostone; D003002:Clonixin
Corpus luteum; Cyclooxygenases; Fertility