[Detoxification of patients with GHB dependence].
BACKGROUND
A new detoxification method for GHB dependence was developed recently in the Netherlands. The method involves the use of pharmaceutical GHB.


OBJECTIVE
To describe the characteristics of GHB dependent inpatients, the course of the detoxification process and patients' progress in the three months following inpatient detoxification.


METHODS
229 GHB dependent patients were monitored during and after inpatient detoxification. Records were kept of the psychiatric symptoms, withdrawal symptoms and relapses.


RESULTS
The average age of the patients was 29 years; 69% of the patients were male. They reported severe symptoms of co-occurring depression and anxiety. Detoxification was successful in 86% of the patients and, on a whole, the procedure ran smoothly, without complications. However, within three months following detoxification two-thirds of the patients had relapsed and were again taking GHB.


CONCLUSIONS
Pharmaceutical GHB can be used as an alternative to the benzodiazepine method for detoxifying patients with GHB dependence. However, the high relapse rates following detoxification are of great concern.
G H
GH
de Weert-van Oene
A F A
AF
Schellekens
B A G
BA
Dijkstra
R
R
Kamal
C A J
CA
de Jong
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012978:Sodium Oxybate / Q000009:adverse effects / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000188:drug therapy*
D012978:Sodium Oxybate