Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases.
Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and the biosynthesis of bioactive natural products. In this perspective article, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Sarah M
SM
Barry
Gregory L
GL
Challis
Amine Oxidation; Biodegradation; Biosynthesis; C-H functionalization; Dihydroxylation; Oxidative Cyclisation