Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients.
We evaluated secreted wingless (Wnt) modulators during cytomegalovirus (CMV) infection in solid organ transplant recipients (SOTr). The major findings were: (i) Plasma levels of Dickkopf-1 (DKK-1) were significantly lower in patients with CMV DNAemia above lower level of quantification at baseline. (ii) Receiver operating characteristic analysis indicated that low DKK-1 and increased secreted frizzled related protein-3 levels were predictors of poor virological outcomes during follow-up. Our findings demonstrate an imbalanced pattern of circulating secreted Wnt modulators in SOTr with poor virological outcomes following treatment for CMV disease, and may suggest a role for dysregulated Wnt signaling on viral pathogenesis during CMV infection.
Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
T
T
Ueland
H
H
Rollag
A
A
Hartmann
A G
AG
Jardine
A
A
Humar
A E
AE
Michelsen
A A
AA
Bignamini
A
A
Åsberg
P
P
Aukrust
D000328:Adult; D003586:Cytomegalovirus Infections / Q000097:blood / Q000188:drug therapy*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D011506:Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects* / Q000502:physiology; D000094742:Secreted Frizzled-Related Proteins
D004279:DNA, Viral; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D000094742:Secreted Frizzled-Related Proteins; C501126:DKK1 protein, human
CMV infection; Wnt signaling; solid organ transplant recipients; virological outcome