Emerging roles of orphan nuclear receptors in cancer.
A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers.
School of Biological Sciences, Creative Research Initiative Center for Chromatin Dynamics, Seoul National University, Seoul 151-742, South Korea; email: sbaek@snu.ac.kr.
Sung Hee
SH
Baek
Keun Il
KI
Kim
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D057093:Orphan Nuclear Receptors / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011944:Receptors, Androgen / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology
D000970:Antineoplastic Agents; D057093:Orphan Nuclear Receptors; D011944:Receptors, Androgen; D011960:Receptors, Estrogen