[Necroptosis: a programmed cell necrosis].
Cell death is one of the basic life properties. A new type of cell death named necroptosis was discovered and became increasingly noticed attention in recent years. Necroptosis has similar morphological characteristics with cell necrosis and is controlled by special signal pathways. The interaction of the receptor interacting protein 1 (RIP1) and 3 (RIP3) plays a crucial important role in the necroptosis signal pathway. The RIP1 determines whether a cell goes survival and death, and the RIP3 determines the pathway of cell death apoptosis or necrosis. This paper summarizes the knowledge about the necroptosis signal pathways and explores its significance in the organ ischemic injury, inflammation and tumor pathogenesis briefly.
Dept of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Bi-Wei
BW
Song
Lu
L
Wang
D017209:Apoptosis; D006801:Humans; D007249:Inflammation; D009336:Necrosis; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction
C506249:RIPK1 protein, human; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases