Dedifferentiated laryngeal chondrosarcoma: combined morphologic and functional imaging with positron-emission tomography/magnetic resonance imaging.
Chondrosarcoma of the larynx is a rare, low-grade malignancy in terms of histology and clinical behavior. We present an unusual case of laryngeal chondrosarcoma, which developed a large dedifferentiated component on recurrence after primary surgery. The diagnosis of dedifferentiation was suggested in view of the morphological and metabolic findings on hybrid positron-emission tomography/magnetic resonance imaging (PET/MRI) and was subsequently confirmed surgically. Whole-organ, slice-by-slice radiologic-histologic correlation revealed excellent delineation of the well-differentiated and dedifferentiated tumor components with PET/MRI. PET/MRI can provide additional functional information to supplement the morphological mapping and histopathology of these tumors.
Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
Bela S
BS
Purohit
Pavel
P
Dulguerov
Karim
K
Burkhardt
Minerva
M
Becker
D000368:Aged; D001706:Biopsy; D002813:Chondrosarcoma / Q000175:diagnosis* / Q000601:surgery; D003413:Cricoid Cartilage / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D014132:Trachea / Q000601:surgery
Positron-emission tomography/magnetic resonance imaging; dedifferentiated chondrosarcoma; larynx