Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD).
Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: pyh6001@yuhs.ac.
Seok Jong
SJ
Chung
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea; Dementia Center, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea. Electronic address: jh7521@naver.com.
Jong Hun
JH
Kim
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea. Electronic address: jhcho.neuro@gmail.com.
Jeong Hee
JH
Cho
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea. Electronic address: jiyongkim2002@yahoo.co.kr.
Gyu Sik
GS
Kim
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea; Dementia Center, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea. Electronic address: sachoi0416@naver.com.
Sun-Ah
SA
Choi
Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: phlee@yuhs.ac.
Phil Hyu
PH
Lee
Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea; Dementia Center, Ilsan Hospital, National Health Insurance Corporation, Koyang-Shi, South Korea. Electronic address: jhlee@nhimc.or.kr.
Jun Hong
JH
Lee
D000544:Alzheimer Disease / Q000473:pathology*; D015140:Dementia, Vascular / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D056910:Republic of Korea
Cognitive impairment; HTN; Risk factor; Survival; SvaD