Association between CRP gene polymorphism 717A/G, C-reactive protein and neurological deficit in ischemic stroke.
Inflammatory components play an important role in the pathogenesis of arteriosclerosis, one of the main causes of stroke. Blood C-reactive protein (CRP) level is connected with the severity of neurological deficit and disability after stroke. Production of CRP depends on CRP gene polymorphism. This study enrolled 125 patients with ischemic stroke. CRP 717A/G polymorphism was tested in all patients along with an assay of CRP levels measured on the first and tenth day after stroke onset. Neurological deficit on admission and before discharge from hospital was evaluated according to National Institutes of Health Stroke Scale (NIHSS), and then associated with CRP levels and the CRP polymorphism. The CRP 717AA genotype was the most frequent, observed in 53.6% of patients; AG genotype in 40%, and GG genotype in 6.4%. Carriers of the 717GG genotype had a significantly higher CRP level on the first day after stroke versus heterozygotes (p=0.023). The improvement in neurological state evaluated with the NIHSS was significantly better in CRP 717AA patients in comparison with other CRP 717 genotypes (p=0.035). A higher level of CRP on the first day after ischemic stroke was slightly associated with the CRP 717AG genotype. The CRP 717AA genotype promotes improvement of neurological state in patients with ischemic stroke.
Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland. Electronic address: dkotlega@poczta.onet.pl.
Dariusz
D
Kotlęga
Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Przemysław
P
Nowacki
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Monika
M
Białecka
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Mateusz
M
Kurzawski
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Marek
M
Droździk
Clinic of Gynaecology and Urogynaecology, Pomeranian Medical University, Police, Poland.
Sylwester
S
Ciećwież
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D013997:Time Factors
D002097:C-Reactive Protein
C-reactive protein; CRP polymorphism; NIHSS; Stroke