NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities.
Chronic inflammation has a key role in the pathogenesis of multiple diseases that represent major public health and financial concerns, including heart failure (HF), Alzheimer's disease (AD) and arthritis. Nuclear factor kappa β (NF-κβ) is a central component of inflammation; owing to its upstream signaling position, it is considered an attractive target for new anti-inflammatory therapeutics. Hydroxytyrosol is an orally bioavailable polyphenol, obtained from olives, which inhibits NF-κβ activity and has elicited promising efficacy signals in several inflammatory diseases. Here, we further examine the role of NF-κβ in inflammation, provide an introduction to natural products and their anti-inflammatory effects and explore the potential of hydroxytyrosol as a new approach to combating the burden of chronic inflammatory diseases.
CreAgri Inc., Hayward, CA, USA. Electronic address: matthew.killeen@gmail.com.
Matthew J
MJ
Killeen
CreAgri Inc., Hayward, CA, USA.
Mark
M
Linder
CreAgri Inc., Hayward, CA, USA.
Paolo
P
Pontoniere
CreAgri Inc., Hayward, CA, USA.
Roberto
R
Crea
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction
D000893:Anti-Inflammatory Agents; D001688:Biological Products; D016328:NF-kappa B; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol