Four new sesquiterpene lactones from the stem bark of Illicium burmanicum.
Four new sesquiterpene lactones (1), (2), (3), and (4), along with three known sesquiterene, namely, 6,7,10-trihydoxyisodaucane (5), 4β,10β-dihydroxyaromadendrane (6), and sescrassidiol (7) were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined using 1D and 2D NMR, and HRESIMS. The anti-inflammatory activities of these compounds were evaluated by measuring the enzymatic activity of luciferase in NF-κB reporters in a (Luc)-HEK 293 cell line treated with lipopolysaccharide (LPS).
School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China.
Doudou
D
Huang
School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China.
Huaping
H
Deng
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415#, Shanghai 200003, People's Republic of China.
Wansheng
W
Chen
School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China.
Guanghui
G
Huang
School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China.
Cheng
C
Chen
School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People's Republic of China. Electronic address: sssnmr@163.com.
Lianna
L
Sun
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides; D015394:Molecular Structure; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D007783:Lactones; D008070:Lipopolysaccharides; D010936:Plant Extracts; D012717:Sesquiterpenes
Illicium burmanicum; NF-κB; Sesquiterpene lactones