Assessing therapy response of secreting pineal germ cell tumor on simultaneous 18F-choline PET/MRI.
An 18-year-old man presented with 6 weeks' history of diplopia, early morning headaches, and blurred vision; on ophthalmologic examination, Parinaud syndrome was revealed. Brain MRI scan showed a calcified pineal mass. Brain simultaneous PET/MRI with 18F-choline showed an avid enhancing mass occupying the pineal region with restricted diffusion. A second examination after chemotherapy demonstrated reduction in both size and radiotracer activity of the mass. Our study emphasizes the potential of simultaneous 18F-choline PET/MRI being a useful tool for contribution in the diagnosis and treatment assessment in a convenient way with minimal radiation exposure and reduced throughput patient time.
From the *Institute of Nuclear Medicine and †Paediatric & Adolescent Oncology, University College London Hospitals NHS Trust, London, United Kingdom.
Emmanouil
E
Panagiotidis
Ananth
A
Shankar
Asim
A
Afaq
Jamshed
J
Bomanji
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D002794:Choline / Q000031:analogs & derivatives; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D010870:Pineal Gland / Q000000981:diagnostic imaging* / Q000473:pathology; D010871:Pinealoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016896:Treatment Outcome
D019275:Radiopharmaceuticals; C516370:fluoromethylcholine; D005047:Etoposide; D003520:Cyclophosphamide; D002794:Choline; D002945:Cisplatin