Comparative study of novel ultradeformable liposomes: menthosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam.
In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was characterized using confocal laser scanning microscopy (CLSM). The results indicated that the difference in physicochemical characteristics of MTS, TFS and CLP affected the skin permeability. MTS and TFS showed higher flux of MX than CLP. CLSM image showed deformable vesicles mechanism for delivery of MX across the hairless mice skin. Our study suggested that ultradeformable and deformable liposomes (MTS and TFS) had a potential to use as transdermal drug delivery carriers for MX.
Department of Pharmaceutics, Hoshi University.
Sureewan
S
Duangjit
Yasuko
Y
Obata
Hiromu
H
Sano
Yoshinori
Y
Onuki
Praneet
P
Opanasopit
Tanasait
T
Ngawhirunpat
Tsubasa
T
Miyoshi
Satoru
S
Kato
Kozo
K
Takayama
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D008081:Liposomes; D008297:Male; D000077239:Meloxicam; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013843:Thiazines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013844:Thiazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D008081:Liposomes; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam