Enantioselective organocatalytic oxidative enamine catalysis-1,5-hydride transfer-cyclization sequences: asymmetric synthesis of tetrahydroquinolines.
The first organocatalytic enantioselective intramolecular oxidative enamine catalysis and 1,5-hydride transfer-ring closure reaction cascade is described. This neutral reaction cascade allows for the efficient formation of ring-fused tetrahydroquinolines with high enantioselectivities.
Department of Chemistry, Soonchunhyang University, 22 Soonchunhyang-Ro, Asan, Chungnam 336-745, Korea. dyoung@sch.ac.kr.
Young Ku
YK
Kang
Dae Young
DY
Kim
D002384:Catalysis; D003500:Cyclization; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline