Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea.
Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene-4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10-methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione (4), (4R)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Phan Van
PV
Kiem
Chau Van
CV
Minh
Nguyen Xuan
NX
Nhiem
Nguyen Thi
NT
Cuc
Ngo Van
NV
Quang
Hoang Le
HL
Tuan Anh
Bui Huu
BH
Tai
Pham Hai
PH
Yen
Nguyen Thi
NT
Hoai
Kim Young
KY
Ho
Nanyoung
N
Kim
SeonJu
S
Park
Seung Hyun
SH
Kim
D000818:Animals; D047088:Dysidea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry*
D012717:Sesquiterpenes
13C NMR; 1H NMR; Dysidea cinerea; Dysideidae; circular dichroism; marine sponge; muurolane