Identifying colon cancer risk modules with better classification performance based on human signaling network.
Identifying differences between normal and tumor samples from a modular perspective may help to improve our understanding of the mechanisms responsible for colon cancer. Many cancer studies have shown that signaling transduction and biological pathways are disturbed in disease states, and expression profiles can distinguish variations in diseases. In this study, we integrated a weighted human signaling network and gene expression profiles to select risk modules associated with tumor conditions. Risk modules as classification features by our method had a better classification performance than other methods, and one risk module for colon cancer had a good classification performance for distinguishing between normal/tumor samples and between tumor stages. All genes in the module were annotated to the biological process of positive regulation of cell proliferation, and were highly associated with colon cancer. These results suggested that these genes might be the potential risk genes for colon cancer.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: quxiaoli1030@gmail.com.
Xiaoli
X
Qu
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: xrq1989@126.com.
Ruiqiang
R
Xie
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: chenlina@ems.hrbmu.edu.cn.
Lina
L
Chen
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: fengchenchen.finally@gmail.com.
Chenchen
C
Feng
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: yanyanzhou2011@163.com.
Yanyan
Y
Zhou
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: wendyliwan@gmail.com.
Wan
W
Li
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: huanghaobio@gmail.com.
Hao
H
Huang
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: jiaxu.happy@gmail.com.
Xu
X
Jia
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: lvjunjie525@126.com.
Junjie
J
Lv
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: heyuehan56@126.com.
Yuehan
Y
He
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: duyouwen215@163.com.
Youwen
Y
Du
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: lwgbioinfor@gmail.com.
Weiguo
W
Li
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province Postal Code: 150081, China. Electronic address: shiyuchen1988@hotmail.com.
Yuchen
Y
Shi
Institute of Opto-electronics, Harbin Institute of Technology, Harbin, Heilongjiang Province Postal Code: 150080, China. Electronic address: hewm@hit.edu.cn.
Weiming
W
He
D000465:Algorithms; D002965:Classification / Q000379:methods; D003110:Colonic Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D015398:Signal Transduction
Colon cancer; Module