Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice.
In the present study, purified sweet cherry anthocyanins (CACN) were evaluated to determine their inhibitory effects on adipocyte differentiation of 3T3-L1 cells and their anti-obesity properties in male C57BL/6 mice fed with high-fat diet (HFD). CACN prevented HFD-induced obesity in C57BL/6 mice. In vivo experiment revealed that 40 and 200 mg/kg of CACN in food reduced the body weight by 5.2% and 11.2%, respectively. CACN supplementation could also reduce the size of adipocytes, leptin secretion, serum glucose, triglyceride, total cholesterol, LDL-cholesterol and liver triglycerides. Furthermore, CACN could effectively reduce the expression levels of IL-6 and TNFα genes, markedly increase the SOD and GPx activity. Our results indicated that CACN slowed down the development of HFD-induced obesity in male C57BL/6 mice.
College of Biosystems Engineering and Food Science and.
Tao
T
Wu
Qiong
Q
Tang
Zhuoping
Z
Yu
Zichun
Z
Gao
Hao
H
Hu
Wei
W
Chen
Xiaodong
X
Zheng
Ting
T
Yu
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology / Q000627:therapeutic use*; D019440:Anti-Obesity Agents; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat; D019587:Dietary Supplements; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D027861:Prunus / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects*
D000872:Anthocyanins; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D015850:Interleukin-6; D020738:Leptin; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha