Postoperative adiponectin levels in pediatric patients undergoing open heart surgery.
BACKGROUND
Adipose tissue is an important endocrine organ that secretes cytokines, including adiponectin, levels of which are negatively correlated with the severity of the inflammatory process. Aim. To assess the time course of adiponectin levels following open heart surgery with cardiopulmonary bypass and its correlation with early postoperative outcomes.


METHODS
Blood samples were obtained from 24 children undergoing cardiac surgery and analyzed for adiponectin, C-reactive protein, and other inflammatory markers.


RESULTS
Baseline adiponectin levels were negatively correlated with patients' preoperative weight and age. Postoperative adiponectin levels decreased compared to baseline (P = 0.01) and correlated negatively with duration of cardiopulmonary bypass (r = -0.438, P = 0.037), length of stay in the pediatric intensive care unit (r = -0.457, P = 0.025), and the inotropic score (r = -0.471, P = 0.02). Adiponectin levels were positively correlated with sVCAM 1 levels; however, there was no correlation between adiponectin levels and sP selectin, tPA, MCP1, and sCD40.


CONCLUSIONS
The inflammatory response after open heart surgery with cardiopulmonary bypass is associated with a reduction in adiponectin levels. Prolonged or more complicated surgery induced a more substantial inflammatory process characterized by a significant reduction in adiponectin levels over time and a delayed return to baseline levels.
Pediatric Intensive Care Department, Chaim Sheba Medical Center, Safra Children's Hospital, 52621 Tel-Hashomer, Israel ; Sackler School of Medicine, Tel-Aviv University, 39040 Tel-Aviv, Israel.
A
A
Thaler
H
H
Kanety
T
T
Avni
D
D
Mishali
R
R
Hemi
E
E
Yissaschar
C
C
Pariente
G
G
Paret
D
D
Modan-Moses
D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D008297:Male; D011183:Postoperative Complications / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D052242:Adiponectin; D019010:Vascular Cell Adhesion Molecule-1; D002097:C-Reactive Protein