Droplet-based microfluidics: enabling impact on drug discovery.
Over the past two decades, the application of microengineered systems in the chemical and biological sciences has transformed the way in which high-throughput experimentation is performed. The ability to fabricate complex microfluidic architectures has allowed scientists to create new experimental formats for processing ultra-small analytical volumes in short periods and with high efficiency. The development of such microfluidic systems has been driven by a range of fundamental features that accompany miniaturization. These include the ability to handle small sample volumes, ultra-low fabrication costs, reduced analysis times, enhanced operational flexibility, facile automation, and the ability to integrate functional components within complex analytical schemes. Herein we discuss the impact of microfluidics in the area of high-throughput screening and drug discovery and highlight some of the most pertinent studies in the recent literature.
1Department of Chemistry & Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zürich, Zürich, Switzerland.
Oliver J
OJ
Dressler
Richard M
RM
Maceiczyk
Soo-Ik
SI
Chang
Andrew J
AJ
deMello
D000818:Animals; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D006801:Humans; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000379:methods*
fluorescence methods; high-content screening; microfluidics; protein chemistry; protein labeling; proteomics