Hepatitis C virus infection and type 2 diabetes.
Hepatitis C virus (HCV) infection and Type 2 diabetes mellitus (T2DM) are two worldwide, major public health problems with increasing complication and mortality rates. Many epidemiological studies have demonstrated the significant association between T2DM and chronic HCV infection. In this paper we have reviewed the increasing evidence linking HCV infection and DM in more than one field (epidemiology, pathogenesis, clinical aspects, prevention and treatment). We have considered T2DM, acute and chronic HCV infection, and cirrhotic patients. Moreover, we have considered some particular populations, solid organ transplant recipients or HCV/human immunodeficiency virus (HIV) coinfected patients. In the final part we have analyzed the potential effect of the association between HCV infection and the development of DM in term of outcome and possibilities for prevention and treatment.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
P
P
Fallahi
S M
SM
Ferrari
M
M
Colaci
I
I
Ruffilli
R
R
Vita
A
A
Azzi
C
C
Ferri
A
A
Antonelli
E
E
Ferrannini
D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control / Q000821:virology*; D004198:Disease Susceptibility; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D015658:HIV Infections / Q000453:epidemiology; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism / Q000821:virology; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000209:etiology; D015995:Prevalence; D011379:Prognosis; D013959:Thyroid Diseases / Q000209:etiology
D007166:Immunosuppressive Agents; D005947:Glucose