Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn's disease.
The concept of fecal microbiota transplantation (FMT) has been used in traditional Chinese medicine at least since the 4(th) century. Evidence from recent human studies strongly supports the link between intestinal bacteria and inflammatory bowel disease. We proposed that standardized FMT might be a promising rescue therapy for refractory inflammatory bowel disease. However, there were no reports of FMT used in patients with severe Crohn's disease (CD). Here, we report the successful treatment of standardized FMT as a rescue therapy for a case of refractory CD complicated with fistula, residual Barium sulfate and formation of intraperitoneal large inflammatory mass. As far as we know, this is the first case of severe CD treated using FMT through mid-gut.
Fa-Ming Zhang, Hong-Gang Wang, Min Wang, Bo-Ta Cui, Zhi-Ning Fan, Guo-Zhong Ji, Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.
Fa-Ming
FM
Zhang
Hong-Gang
HG
Wang
Min
M
Wang
Bo-Ta
BT
Cui
Zhi-Ning
ZN
Fan
Guo-Zhong
GZ
Ji
D000328:Adult; D001691:Biological Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D003106:Colon / Q000382:microbiology*; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D016099:Endoscopy, Gastrointestinal; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007412:Intestinal Fistula / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology / Q000628:therapy*; D008297:Male; D010865:Pilot Projects; D012074:Remission Induction; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
Crohn’s disease; Fecal microbiota transplantation; Fistula; Inflammatory bowel disease; Rescue therapy