Oral squamous cell carcinoma and serum paraoxonase 1.
BACKGROUND
Serum paraoxonase 1 is involved in mechanisms that protect cells from oxidative stress damage. This study aimed to investigate the correlation between serum paraoxonase 1 activity and polymorphisms in patients with oral squamous cell carcinoma.


METHODS
Fifty-seven patients with oral squamous cell carcinoma and 59 matched healthy controls participated in the study. Serum paraoxonase 1 activity and polymorphisms in blood samples were compared with results for polymerase chain reaction and restriction fragment length polymorphism tests.


RESULTS
Mean serum paraoxonase 1 activity levels were lower in patients than controls (mean ± standard deviation, 21.9 ± 5 units/l and 120.4 ± 2 units/l, respectively) (p = 0.001). The serum paraoxonase 1 192 glutamine polymorphism was more common in patients than controls.


CONCLUSIONS
Patients with oral squamous cell carcinoma had significantly lower serum paraoxonase 1 activity levels and a greater prevalence of the serum paraoxonase 1 192 glutamine allele, compared with controls. Serum paraoxonase 1 may play a role in the aetiology of oral squamous cell carcinoma.
Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Z Boy
ZB
Metin
Department of Otorhinolaryngology, Bağcilar Research and Education Hospital, Istanbul, Turkey.
S
S
Aydin
Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
M
M
Unur
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
B
B
Cakmakoglu
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
B
B
Toptas
Department of Otolaryngology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
G
G
Hafiz
Department of Molecular Medicine, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
T
T
İsbir
D000483:Alleles; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
D014408:Biomarkers, Tumor; D043303:Aryldialkylphosphatase