2H-pyran-2-one and 2H-furan-2-one derivatives from the plant endophytic fungus Pestalotiopsis fici.
Two new α-pyrones (=2H-pyran-2-ones), ficipyrones A and B (1 and 2, resp.), and two new α-furanones (=2H-furan-2-ones), ficifuranones A and B (3 and 4, resp.), together with three known metabolites, antibiotic F 0368 (5), hydroxyseiridin (6), and hydroxyisoseiridin (7), were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute configuration of 1 was deduced from the circular-dichroism (CD) data. Compound 1 showed antifungal activity against the plant pathogen Gibberella zeae (CGMCC 3.2873) with an IC50 value of 15.9 μM.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China (phone: +86-10-64806153).
Shuchun
S
Liu
Xiangyu
X
Liu
Liangdong
L
Guo
Yongsheng
Y
Che
Ling
L
Liu
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D005874:Gibberella / Q000187:drug effects; D010944:Plants / Q000382:microbiology; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013098:Xylariales / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D011753:Pyrones
2H-Furan-2-ones; 2H-Pyran-2-ones; Antifungal activity; Fungi; Pestalotiopsis fici