The cardiovascular effects of sevoflurane and isoflurane after premedication of healthy dogs undergoing elective surgery.
Sevoflurane and isoflurane are commonly used in veterinary anesthesia. The objective of this prospective, randomized, open-label clinical study was to compare the cardiovascular effects of sevoflurane and isoflurane via direct arterial blood pressure measurements and the lithium dilution cardiac output (LDCO) on premedicated healthy dogs undergoing elective tibial plateau leveling osteotomy (TPLO). Nineteen client-owned dogs were included. All dogs were premedicated with hydromorphone (0.05 mg/kg IV and glycopyrrolate 0.01 mg/kg subcutaneously). Ten dogs were anesthetized with sevoflurane and nine dogs were anesthetized with isoflurane. Eighteen dogs were instrumented with a dorsal pedal arterial catheter, and one dog had a femoral arterial catheter. All dogs had continuous, direct systolic (SAP), diastolic (DAP), and mean arterial (MAP) blood pressure readings as well as heart rate (HR), cardiac output (CO), cardiac index (CI), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), stroke volume variation (SVV), and pulse pressure variation (PPV) recorded q 5 min during the surgical procedure. There was no significant statistical difference in all parameters between the sevoflurane and isoflurane treatment groups. Both sevoflurane and isoflurane inhalant anesthetics appear to have similar hemodynamic effects when used as part of a multimodal anesthetic protocol in premedicated healthy dogs undergoing an elective surgical procedure.
Department of Emergency and Critical Care, Veterinary Specialty Hospital of San Diego, San Diego, CA; and Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA (B.B.).
Janan M
JM
Abed
Fred S
FS
Pike
Monica C
MC
Clare
Benjamin M
BM
Brainard
D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D017558:Elective Surgical Procedures / Q000662:veterinary; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D010027:Osteotomy / Q000662:veterinary; D011292:Premedication / Q000662:veterinary; D011446:Prospective Studies; D000077149:Sevoflurane; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane