Enalapril-induced acute kidney injury in neonates.
Angiotensin converting enzyme inhibitors have been used in the neonatal population for both cardiac and renal diseases. Past reports have described deleterious renal and neurological consequences as a result of these drugs. This report describes two infants receiving enalapril for different indications who suffered renal impairments, likely a result of concomitant diuretic use. These cases demonstrate the risks associated with ACE inhibitor use and the importance of vigilant monitoring when using these medications.
Division of Newborn Medicine, New York Presbyterian Hospital Weill Cornell, NY, USA.
A
A
Russo
A
A
Mirani
J
J
Perlman
S
S
Miller
D058186:Acute Kidney Injury / Q000139:chemically induced*; D001003:Anal Canal / Q000002:abnormalities / Q000601:surgery; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects*; D004947:Esophagus / Q000002:abnormalities / Q000601:surgery; D006330:Heart Defects, Congenital / Q000601:surgery; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities / Q000601:surgery; D017880:Limb Deformities, Congenital / Q000601:surgery; D008297:Male; D013131:Spine / Q000002:abnormalities / Q000601:surgery; D014132:Trachea / Q000002:abnormalities / Q000601:surgery; D014188:Transposition of Great Vessels / Q000601:surgery
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril
ACE inhibitors; Hypotension; congestive heart failure; oliguria