Adrenalectomy for solid tumor metastases: results of a multicenter European study.
BACKGROUND
We assessed the results of adrenalectomy for solid tumor metastases in 317 patients recruited from 30 European centers.


METHODS
Patients with histologically proven adrenal metastatic disease and undergoing complete removal(s) of the affected gland(s) were eligible.


RESULTS
Non-small cell lung cancer (NSCLC) was the most frequent tumor type followed by colorectal and renal cell carcinoma. Adrenal metastases were synchronous (≤6 months) in 73 (23%) patients and isolated in 213 (67%). The median disease-free interval was 18.5 months. Laparoscopic resection was used in 46% of patients. Surgery was limited to the adrenal gland in 73% of patients and R0 resection was achieved in 86% of cases. The median overall survival was 29 months (95% confidence interval, 24.69-33.30). The survival rates at 1, 2, 3, and 5 years were 80%, 61%, 42%, and 35%, respectively. Patients with renal cancer showed a median survival of 84 months, patients with NSCLC 26 months, and patients with colorectal cancer 29 months (P = .017). Differences in survival between metachronous and synchronous lesions were also significant (30 vs. 23 months; P = .038).


CONCLUSIONS
Surgical removal of adrenal metastasis is associated with long-term survival in selected patients.
Unidad de Cirugía Endocrina, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: 25108pml@gmail.com.
Pablo
P
Moreno
Aitor
A
de la Quintana Basarrate
Thomas J
TJ
Musholt
Ivan
I
Paunovic
Marco
M
Puccini
Oscar
O
Vidal
Joaquín
J
Ortega
Jean-Louis
JL
Kraimps
Elisabet
E
Bollo Arocena
José M
JM
Rodríguez
Oscar
O
González López
Carlos D
CD
Del Pozo
Maurizio
M
Iacobone
Enrique
E
Veloso
José M
JM
Del Pino
Iñigo
I
García Sanz
David
D
Scott-Coombes
Jesús
J
Villar-Del-Moral
José I
JI
Rodríguez
Jaime
J
Vázquez Echarri
Carmen
C
González Sánchez
María-Teresa
MT
Gutiérrez Rodríguez
Ignacio
I
Escoresca
José
J
Nuño Vázquez-Garza
Ernesto
E
Tobalina Aguirrezábal
Jesús
J
Martín
Mari Fe
MF
Candel Arenas
Kerstin
K
Lorenz
Juan M
JM
Martos
José M
JM
Ramia
D000310:Adrenal Gland Neoplasms / Q000556:secondary* / Q000601:surgery*; D000315:Adrenalectomy; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000556:secondary / Q000601:surgery; D015179:Colorectal Neoplasms; D018572:Disease-Free Survival; D005060:Europe; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms; D010535:Laparoscopy; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies