Cardiac arrhythmias and conduction defects in systemic sclerosis.
Signs and symptoms of arrhythmias or conduction defects are frequently reported in patients with SSc. These rhythm disorders may have several origins (i.e., related to primary heart involvement, pericardial disease, valvular regurgitation or pulmonary arterial hypertension) and may negatively affect the overall prognosis of these patients. It is therefore important to identify patients at high risk for cardiac arrhythmias with a complete cardiological evaluation and to identify the underlying heart disease, including SSc-related myocardial involvement. In addition, some therapeutic options in SSc patients may differ from those recommended in other populations.
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Alessandra
A
Vacca
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Christophe
C
Meune
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Jessica
J
Gordon
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division
Lorinda
L
Chung
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Susanna
S
Proudman
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Shervin
S
Assassi
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Mandana
M
Nikpour
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Tatiana S
TS
Rodriguez-Reyna
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Dinesh
D
Khanna
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Robert
R
Lafyatis
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Marco
M
Matucci-Cerinic
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.
Oliver
O
Distler
Unit and Chair of Rheumatology, University and A.O.U. of Cagliari, Cagliari, Italy, Cardiology Department, Avicenne Hospital, Bobigny and Cochin Hospital, Paris XIII University, APHP, Paris, France, Department of Rheumatology, Hospital for Special Surgery, New York, NY, Stanford University School of Medicine, Stanford, VA Palo Alto Health Care System, Palo Alto, CA, USA, Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia, Health Science Center at Houston, University of Texas, Houston, TX, USA, St Vincent's Hospital, University of Melbourne, Fitzroy, Melbourne, VIC, Australia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Boston University School of Medicine, Boston, MA, USA, Rheumatology Division, Department of Internal Medicine, University of Florence, Florence, Italy, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France. yannick.allanore@cch.aphp.fr.
Yannick
Y
Allanore
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000503:physiopathology*
D000889:Anti-Arrhythmia Agents
arrhythmias; cardiac involvement; conduction defects; mortality; systemic sclerosis