A mechanism for poor high mass performance in fourier transform mass spectrometry.
The discovery of a mass-dependent electrical mechanism for signal loss of high mass ions in Fourier transform mass spectrometry is reported. Theoretical calculations and experimental evidence show the existence of resonances involving the z-motion and radial motion of the ion. The resonances are intrinsic in the cubic trap. This results in energy transfer between modes, expansion of the ion cloud, and a corresponding loss of signal. Quadrupolar trapping potential wells are proposed as a solution.
Midwest Center for Mass Spectrometry, Department of Chemistry, University of Nebraska, 68588 -0304, Lincoln, NE, USA.
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Holliman
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Rempel
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Gross