Overexpression of Bcl-3 inhibits the development of marginal zone B cells.
The transcription factor Bcl-3 functions as a proto-oncogene via regulation of cell proliferation and apoptosis. Bcl-3 is an atypical member of the IκB family and plays a central role in the immune response through interactions with the NF-κB subunits p50 and p52. To investigate the impact of Bcl-3 on B-cell maturation and regulation, we generated mice that overexpress Bcl-3 specifically in B cells. Interestingly, these mice lack marginal zone B cells and exhibit a significant reduction in the number of B-1 B cells. Further, B cells from these mice are impaired in their proliferative capacity. Our data demonstrate that the overexpression of the transcription factor Bcl-3 inhibits germinal center formation, marginal zone B-cell development, and affects the B-1 B-cell compartment.
Institute for Molecular Medicine, Johannes Gutenberg-University of Mainz, Mainz, Germany.
Nadine
N
Hövelmeyer
Marcus A
MA
Wörns
Sonja
S
Reissig
Petra
P
Adams-Quack
Jennifer
J
Leclaire
Matthias
M
Hahn
Simone
S
Wörtge
Alexei
A
Nikolaev
Peter R
PR
Galle
Ari
A
Waisman
D000818:Animals; D000081242:B-Cell Lymphoma 3 Protein; D001402:B-Lymphocytes / Q000378:metabolism*; D049109:Cell Proliferation; D015870:Gene Expression / Q000235:genetics*; D018858:Germinal Center / Q000378:metabolism; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
D000081242:B-Cell Lymphoma 3 Protein; C000631345:Bcl3 protein, mouse; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors
B-1 B cells; Bcl-3; Marginal zone B cell; NF-κB