Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature.
Solitary fibrous tumor (SFT) is a rare mass-forming soft tissue tumor that occurs most commonly in the pleura, but has been described in various extrathoracic sites. Extrapleural manifestation of SFT, particularly in the head and neck region, is rare. The most common extrapleural site is the oral cavity; these tumors have also been described in the orbit, nasopharynx, paranasal sinuses, salivary glands, and larynx. We report an extremely rare case of a SFT in the subcutaneous region of the cheek. This tumor in the left cheek was a large firm mass, approximately 8.5 cm × 6 cm in size and was successfully treated by surgical resection. Immunohistochemistry revealed reactivity for vimentin, CD34, and bcl-2, but no staining for cytokeratin, epithelial membrane antigen, S-100, desmin, caldesmon, actin, α-smooth muscle actin, CD117, and CD99. Immunohistochemical study is the key to establish a definitive diagnosis of SFT, and ultrastructural study is also useful for making an accurate diagnosis. The patient recovered uneventfully without evidence of tumor recurrence 2 years after surgery.
Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan, tsatomi@tokyo-med.ac.jp.
Takafumi
T
Satomi
On
O
Hasegawa
Harutsugu
H
Abukawa
Michihide
M
Kohno
Ai
A
Enomoto
Daichi
D
Chikazu
Jun
J
Matsubayashi
Toshitaka
T
Nagao
D018952:Antigens, CD34 / Q000378:metabolism; D002610:Cheek / Q000473:pathology* / Q000601:surgery*; D005153:Facial Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008279:Magnetic Resonance Imaging; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D014746:Vimentin / Q000378:metabolism
D018952:Antigens, CD34; D014746:Vimentin