Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: differentiating pseudoprogression from tumor progression and its effect on clinical practice.
Stereotactic radiosurgery has become standard adjuvant treatment for patients with metastatic intracranial lesions. There has been a growing appreciation for benign imaging changes following radiation that are difficult to distinguish from true tumor progression. These imaging changes, termed pseudoprogression, carry significant implications for patient management. In this review, we discuss the current understanding of pseudoprogression in metastatic brain lesions, research to differentiate pseudoprogression from true progression, and clinical implications of pseudoprogression on treatment decisions.
Department of Neurological Surgery, The Johns Hopkins University School of Medicine, Phipps Building, Room 126, 600 N. Wolfe Street, Baltimore, MD, 21287, USA, jruzevick@jhmi.edu.
Jacob
J
Ruzevick
Lawrence
L
Kleinberg
Daniele
D
Rigamonti
D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D018450:Disease Progression; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D016634:Radiosurgery / Q000379:methods