[Disturbances of the immune status during chronic intoxication with 1,2-dichloroethane and their treatment by administration of polyoxidonium].
It has been established in experiments on noninbred rats that chronic intoxication with 1,2-dichloroethane (30 days; total dose 0.9LD50; daily dose 0.03 mg/kg body weight) causes a reduction of immune responses, decreases the activity of acetylcholinesterase (AChE) of T-lymphocytes, reduces the concentration of blood cytokines (IFN-gamma, IL-2, IL-4, IL-6, while not affecting the content of IL-10), and damages to a greater degree Th1 cells as compared to Th2 lymphocytes. The administration of polyoxidonium (daily dose, 150 mg/kg, for 7 days,) partially restored the immune status, the activity of AChE T cells, and the content of cytokines in the blood.
P F
PF
Zabrodskiĭ
M S
MS
Gromov
I Kh
IKh
Iafarova
D000110:Acetylcholinesterase / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D005025:Ethylene Dichlorides / Q000633:toxicity*; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D005025:Ethylene Dichlorides; D007155:Immunologic Factors; D010879:Piperazines; D011108:Polymers; C024565:ethylene dichloride; C540909:azoximer bromide; D000110:Acetylcholinesterase