[Association between left ventricular diastolic function and blood pressure variability in essential hypertensive patients].
OBJECTIVE
To investigate the relationship between blood pressure variability (BPV) and left ventricular diastolic function in patients with essential hypertension.


METHODS
Left ventricular diastolic function of 252 hypertensive patients were assessed by early (E) diastolic transmitral flows to early diastolic mitral annular velocity (Ea) (E/Ea) ratio derived from Doppler echocardiography. Patients were divided into two groups according to normal left ventricular diastolic function group (E/Ea<15, n = 168) and left ventricular diastolic dysfunction group (E/Ea ≥ 15, n = 84). All patients were monitored by ambulatory blood pressure. Standard deviation (SD) and coefficient of variation (CV) of blood pressure were calculated as the BPV. Relationship between BPV and left ventricular diastolic function were analyzed by multivariate logistic regression analysis.


RESULTS
All-day average diastolic blood pressure(DBP), the day systolic blood pressure (SBP), night SBP, night DBP, SBPSD, DBPSD and DBPCV in the left ventricular diastolic dysfunction group were significantly higher than in the normal diastolic function group (all P < 0.05). Multivariate logistic regression analysis showed that left ventricular diastolic dysfunction was associated with SBPSD (OR:1.126, 95%CI:1.054-1.203, P < 0.01), SBPCV (OR:1.127, 95%CI:1.036-1.225, P < 0.01) in this patient cohort.


CONCLUSIONS
High variability of SBP is correlated with left ventricular diastolic dysfunction in hypertensive patients.
Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China.
Gai-ling
GL
Chen
Ming-jian
MJ
Wang
Jun-ming
JM
Liu
Wei
W
Xie
Wen-jun
WJ
Huang
Yong
Y
Wang
Yuan-nan
YN
Ke
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003971:Diastole / Q000502:physiology; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology*