A chiral sulfoxide-ligated ruthenium complex for asymmetric catalysis: enantio- and regioselective allylic substitution.
The design and synthesis of a novel chiral sulfoxide-ligated cyclopentadienyl ruthenium complex is described. Its utility as an asymmetric variant of [CpRu(MeCN)3]PF6 is demonstrated through its ability to function in the branched-selective asymmetric allylic alkylation of phenols and carboxylic acids. Water has also been shown to act as a competent nucleophile in this reaction to generate branched allyl alcohols with good regio- and enantioselectivities.
Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
Barry M
BM
Trost
Meera
M
Rao
André P
AP
Dieskau