Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective.
Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.
Hendrik
H
Gremmels
Joost O
JO
Fledderus
Martin
M
Teraa
Marianne C
MC
Verhaar
D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000473:pathology*; D007866:Leg / Q000473:pathology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D016491:Peripheral Vascular Diseases / Q000628:therapy*