Lymphoma as a second malignancy in a patient with neuroendocrine tumor: mimicking dedifferentiation on dual-tracer PET/CT with 68Ga-DOTANOC and 18F-FDG.
Neuroendocrine tumors (NETs) are rare tumors which express somatostatin receptors (SSTRs). We here present a case of a 50-year-old female patient with metastatic bronchial carcinoid. She underwent 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT which suggested a diagnosis of poorly differentiated NET. Biopsy of the lesion, however, revealed a second malignancy in the form of diffuse large B-cell lymphoma. Thus, very rarely, other primary tumors can mimic NETs on dual-tracer PET/CT, and biopsy is advised in doubtful cases.
From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sachin
S
Jain
Punit
P
Sharma
Varun Singh
VS
Dhull
Chandrasekhar
C
Bal
Rakesh
R
Kumar
D054337:Cell Dedifferentiation; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008875:Middle Aged; D064847:Multimodal Imaging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018358:Neuroendocrine Tumors / Q000473:pathology*; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019788:Fluorodeoxyglucose F18