Reirradiation of the eye with plaque brachytherapy: a single institution experience report of eight consecutive patients submitted to retreatment after local relapse of malignant disease of the eye.
OBJECTIVE
To evaluate the feasibility of reirradiation of the eye with plaque brachytherapy (REPBT) for local recurrence (LR) of malignant disease of the eye as an alternative to enucleation or other local salvage treatments.


METHODS
It was performed a retrospective analysis of all patients who underwent REPBT for LR. The main parameters evaluated were local control and progression-free survival, besides the toxicity profile.


RESULTS
There were eight patients who underwent REPBT, seven due to uveal melanoma and one due to retinoblastoma. The median time between the first plaque brachytherapy and the salvage plaque brachytherapy was 24 months (8-49 months). After a median followup of 30 months (8-70 months), the actuarial 2-year local control and progression-free survival was 87.5% and 60%, respectively. All patients evolved with worsening of the visual acuity and cataract. Other complications observed were maculopathy (two patients) and glaucoma (one patient).


CONCLUSIONS
REPBT should be considered as an option for salvage therapy of LR of malignant disease of the eyes as it provides a high probability of tumor control and eye preservation without compromising disease-free survival.
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil. Electronic address: nevesdfgs@gmail.com.
Daniel Ferreira
DF
Gaspar de Souza Neves
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Maria Alice
MA
Ferragut
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Dominihemberg Vasconcelos
DV
Ferreira
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Daniel Grossi
DG
Marconi
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Antônio Cássio
AC
Assis Pellizzon
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Maria Aparecida
MA
Conte Maia
Department of Ophthalmology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Maria Alice
MA
Fernandes Costela Freitas
Department of Ophthalmology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Maria Marta
MM
Motono Chojniak
Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo/SP, Brazil.
Douglas
D
Guedes de Castro
D000293:Adolescent; D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D019572:Retinal Neoplasms / Q000532:radiotherapy*; D012175:Retinoblastoma / Q000532:radiotherapy*; D019233:Retreatment; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods; D013997:Time Factors; D014604:Uveal Neoplasms / Q000532:radiotherapy*; D014792:Visual Acuity; D055815:Young Adult; D000098943:Uveal Melanoma
Brachytherapy; Choroid melanoma; Retinoblastoma; Uveal neoplasms