Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice.
OBJECTIVE
Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology remains largely unknown.


METHODS
In this study, we evaluated the effects of trehalose in APP/PS1 transgenic mice through behaviour tests and biochemical analyses.


RESULTS
We found that the impaired cognitive and learning ability was improved and Aβ deposit in hippocampus was reduced.


CONCLUSIONS
These results suggested that trehalose could be a potential therapeutic drug for the treatment of AD.
Department of Pharmacology, School of Medicine, Tsinghua University, Beijing, China; Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing, China.
Jing
J
Du
Yu
Y
Liang
Feng
F
Xu
Bing
B
Sun
Zhao
Z
Wang
D000544:Alzheimer Disease / Q000188:drug therapy*; D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010641:Phenotype; D053764:Presenilin-1 / Q000502:physiology*; D014199:Trehalose / Q000627:therapeutic use*
D016564:Amyloid beta-Protein Precursor; D018696:Neuroprotective Agents; D053764:Presenilin-1; D014199:Trehalose
biological evaluation of natural products; drugs from natural sources; molecular and clinical pharmacology; whole body pharmacology