Plants: a source for new antimycobacterial drugs.
Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previously explored sources were examined and around 353 antimycobacterial compounds (Nat Prod Rep 2007; 24: 278-297) 7 have been previously reported. To develop drugs from these new sources, additional work is required for preclinical and clinical results. Since ancient times, different plant part extracts have been used as traditional medicines against diseases including tuberculosis. This knowledge may be useful in developing future powerful drugs. Plant natural products are again becoming important in this regard. In this review, we report 127 antimycobacterial compounds and their antimycobacterial activities. Of these, 27 compounds had a minimum inhibitory concentration of < 10 µg/mL. In some cases, the mechanism of activity has been determined. We hope that some of these compounds may eventually develop into effective new drugs against tuberculosis.
School of Chemical and Biotechnology, SASTRA University, Thanjavur, India.
Ramachandran Sarojini
RS
Santhosh
School of Chemical and Biotechnology, SASTRA University, Thanjavur, India.
Balasubramanian
B
Suriyanarayanan
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D047188:Chalcones; D003374:Coumarins; D005227:Fatty Acids; D005419:Flavonoids; D010636:Phenols; D011809:Quinones; D013729:Terpenes