Predictors of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism.
We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism. The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing para-thyroidectomy: the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol/L or less, and the normocalcemia group (48 patients), with post-operative serum Ca levels higher than 2 mmol/L. By using multivariate stepwise logistic regression analysis, high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcemia with an adjusted odds ratio (aOR) of 3.01, followed by hypo-albuminemia (aOR = 2.72), younger age (aOR = 2.56), and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28). We conclude that among patients with secondary hyperparathyroidism, age, levels of pre-operative serum Ca, ALP and albumin correlate positively with the development of early post-operative hypocalcemia. Patients with one of these factors should be monitored more closely in the early post-parathyroidectomy period.
Department of Nephrology, Fattouma Bourguiba Hospital; Department of Epidemiology, University Hospital of Monastir University Faculty of Medicine, Monastir, Tunisia.
M
M
Hamouda
N Ben
NB
Dhia
S
S
Aloui
S
S
El Mhamedi
H
H
Skhiri
M
M
Elmay
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000601:surgery*; D006996:Hypocalcemia / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D055815:Young Adult
D010281:Parathyroid Hormone