Water-soluble cationic conjugated polymers: response to electron-rich bioanalytes.
We report the concise synthesis of a symmetrical monomer that provides a head-to-head pyridine building block for the preparation of cationic conjugated polymers. The obtained poly(pyridinium-phenylene) polymers display appealing properties such as high electron affinity, charge-transport upon n-doping, and optical response to electron-donating analytes. A simple assay for the optical detection of low micromolar amounts of a variety of analytes in aqueous solution was developed. In particular, caffeine could be measured at a 25 μM detection limit. The reported polymers are also suitable for layer-by-layer film formation.
Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Sébastien
S
Rochat
Timothy M
TM
Swager
D002110:Caffeine / Q000032:analysis*; D004583:Electrons; D057230:Limit of Detection; D008958:Models, Molecular; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry*
D011108:Polymers; D011725:Pyridines; D014867:Water; D002110:Caffeine; C023666:pyridine