Quantitative analysis of PiB-PET with FreeSurfer ROIs.
In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions.
Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America ; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, Missouri, United States of America.
Yi
Y
Su
Gina M
GM
D'Angelo
Andrei G
AG
Vlassenko
Gongfu
G
Zhou
Abraham Z
AZ
Snyder
Daniel S
DS
Marcus
Tyler M
TM
Blazey
Jon J
JJ
Christensen
Shivangi
S
Vora
John C
JC
Morris
Mark A
MA
Mintun
Tammie L S
TL
Benzinger
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000814:Aniline Compounds; D052160:Benzothiazoles; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods; D058225:Plaque, Amyloid / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012984:Software; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles