Promoting remyelination in multiple sclerosis-recent advances.
We review the current state of knowledge of remyelination in multiple sclerosis (MS), concentrating on advances in the understanding of the pathology and the regenerative response, and we summarise progress on the development of new therapies to enhance remyelination aimed at reducing progressive accumulation of disability in MS. We discuss key target pathways identified in experimental models, as although most identified targets have not yet progressed to the stage of being tested in human clinical trials, they may provide treatment strategies for demyelinating diseases in the future. Finally, we discuss some of the problems associated with testing this class of drugs, where they might fit into the therapeutic arsenal and the gaps in our knowledge.
E Jolanda
EJ
Münzel
MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh Bioquarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
E
E
Jolanda Münzel
Anna
A
Williams
D000818:Animals; D002986:Clinical Trials as Topic; D003711:Demyelinating Diseases / Q000188:drug therapy* / Q000473:pathology*; D018450:Disease Progression; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology*