Organocatalyzed stereospecific C-C bond formation of β-lactams.
Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C-C bond forming reactions.
Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa. govenderthav@ukzn.ac.za.
Sachin A
SA
Pawar
Saba
S
Alapour
Sibusiso
S
Khanyase
Zamani E D
ZE
Cele
Srinivas
S
Chitti
Hendrik G
HG
Kruger
Thavendran
T
Govender
Per I
PI
Arvidsson
D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C116609:3-hydroxybutanal