Attention orienting dysfunction with preserved automatic auditory change detection in migraine.
OBJECTIVE
To investigate automatic event-related potentials (ERPs) to an auditory change in migraine patients.


METHODS
Auditory ERPs were recorded in 22 female patients suffering from menstrually-related migraine and in 20 age-matched control subjects, in three sessions: in the middle of the menstrual cycle, before and during menses. In each session, 200 trains of tone-bursts each including two duration deviants were presented in a passive listening condition.


RESULTS
In all sessions, duration deviance elicited a mismatch negativity (MMN) showing no difference between the two groups. However, migraine patients showed an increased N1 orienting component to all incoming stimuli and a prolonged N2b to deviance. They also presented a different modulation of P3a amplitude along the menstrual cycle, which tended to normalise during migraine attacks. None of the studied ERP components showed a default of habituation.


CONCLUSIONS
This passive paradigm highlighted increased automatic attention orienting to auditory changes but normal auditory sensory processing in migraineurs.


CONCLUSIONS
Our observations suggest normal auditory processing up to attention triggering but enhanced activation of attention-related frontal networks in migraineurs.
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France. Electronic address: dominique.morlet@inserm.fr.
Dominique
D
Morlet
Hospices Civils de Lyon, Croix-Rousse Hospital, Neurology Department, Lyon F-69000, France.
Geneviève
G
Demarquay
Tonkin Clinic, Villeurbanne F-69100, France.
Frédérique
F
Brudon
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France; Hospices Civils de Lyon, Neurological Hospital, Functional Neurology and Epileptology Department, Lyon F-69000, France.
Catherine
C
Fischer
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France.
Anne
A
Caclin
D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention; D001307:Auditory Perception; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology* / Q000523:psychology*; D055815:Young Adult
Attention orienting; Event-related potentials; MMN; Migraine; N2b; P3a