[Influence of lithium salt of comenic acid on the state of oxidative processes in brain of stressed animals].
The influence of a new substance, lithium salt of comenic acid, on the oxidative processes in the brain of animals under the conditions of acute and long combined stress has been investigated. It is established that lithium comenate (1 and 2 mg/kg) exhibits pronounced dose-dependent antioxidative stress-protective effect, which is manifested in suppression of the hyperproduction of free radicals and depression of the content of malonic dialdehyde (a secondary product of lipid peroxidation) in the brain of stressed animals. The maximum antioxidative stress protection effect under the conditions of acute and long combined stress has been observed for lithium salt ofcomenic acid in a dose of 2 mg/kg.
L V
LV
shurygina
É I
ÉI
Zlishcheva
A A
AA
Kravtsov
T V
TV
Androsova
L A
LA
Poleshchuk
N O
NO
Abramova
L I
LI
Zlishcheva
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D008094:Lithium; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D002264:Carboxylic Acids; D005609:Free Radicals; D011753:Pyrones; C488376:comenic acid; D008094:Lithium