Prominent mucoid degeneration of the parotid gland in a patient with systemic lupus erythematosus.
Lupus erythematosus (LE) can cause various cutaneous lesions including panniculitis (LE profundus), but salivary gland involvement has been extremely rare in patients with LE. Herein, we report the first documented case of systemic LE with prominent mucoid degeneration and lymphoplasmacytic infiltration in the parotid gland. A 38-year-old Japanese male with histories of autoimmune hemolytic anemia and systemic LE presented with a swelling of the bilateral cervical region. A physical examination revealed a swelling of the bilateral parotid gland and erythema of the right cheek. A biopsy specimen of the cheek demonstrated LE profundus with mucoid material deposition in the dermis. A biopsy specimen of the parotid gland showed lymphoplasmacytic infiltration and prominent mucoid material deposition within the parotid gland as well as mild lymphoplasmacytic infiltration and hyaline fat necrosis in the perisalivary tissue. Mucoid material deposition is one of the characteristic features of LE, however, this is the first case demonstrating mucoid material deposition in the salivary gland. Moreover, albeit extremely rare, lymphoplasmacytic infiltration within the lobules of the salivary gland has also been reported in patients with LE. Therefore, it is important that both lymphoplasmacytic infiltration and mucoid material deposition must be included in the differential diagnostic considerations for salivary gland tumors in patients who had been previously diagnosed as systemic or discoid LE.
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.
Mitsuaki
M
Ishida
Muneo
M
Iwai
Keiko
K
Yoshida
Akiko
A
Kagotani
Keiko
K
Hodohara
Hidetoshi
H
Okabe
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D005218:Fat Necrosis; D006801:Humans; D007150:Immunohistochemistry; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D015435:Panniculitis, Lupus Erythematosus / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D010305:Parotid Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D010306:Parotid Gland / Q000276:immunology / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology; D011237:Predictive Value of Tests
D015415:Biomarkers
Systemic lupus erythematosus; lupus erythematosus profundus; mucoid degeneration; parotid gland