Cucurbit[n]uril type hosts for the reversal of steroidal neuromuscular blocking agents.
The ideal neuromuscular blocking agent (NMBA) is regarded as being a non-depolarizing equivalent of succinylcholine, having a rapid onset and short duration of action, with minimal side effects. In the absence of a single drug, the administration of an aminosteroid NMBA, such as rocuronium, followed by reversal using an acetylcholinesterase inhibitor, such as neostigmine, is commonly employed. A different and safer approach to rapidly reversing the action of the NMBA, by encapsulating it with a macrocyclic or acyclic host molecule, such as the cyclodextrin sugammadex or more recently, cucurbituril-type hosts such as cyclic cucurbit[7]uril and the acyclic glycoluril tetramer calabadion 1, is described.
Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada. donal@chem.queensu.ca.
Donal H
DH
Macartney
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003505:Cyclodextrins / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000737:chemistry; D000099246:Cucurbit(n)urils
D002800:Cholinesterase Inhibitors; D003505:Cyclodextrins; D004337:Drug Carriers; D047028:Macrocyclic Compounds; D009466:Neuromuscular Blocking Agents; D000077122:Sugammadex; D047408:gamma-Cyclodextrins; D000099246:Cucurbit(n)urils