Tumor-infiltrating follicular helper T cells: The new kids on the block.
By analyzing CD4+lymphocytes in human breast carcinomas, we have recently uncovered the presence of follicular helper T cells in lesions exhibiting an extensive immune infiltrate. The presence of these specialized CD4+T cells, which localize to the germinal centers of peritumoral tertiary lymphoid structures found in extensively infiltrated neoplastic lesions, predicts improved disease outcome among breast carcinoma patients.
Molecular Immunology Unit; Institut Jules Bordet; Université Libre de Bruxelles; Brussels, Belgium.
Chunyan
C
Gu-Trantien
Karen
K
Willard-Gallo
CXCL13; anticancer immunity; breast cancer; follicular helper T cells; tertiary lymphoid structures; tumor-infiltrating lymphocytes