Green synthesis and biological evaluation of new di-α-aminophosphonate derivatives as cytotoxic agents.
A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2 O under ultrasonic irradiation and were characterized by IR, (1) H NMR, (13) C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity.
Department of Chemistry, Yonsei University, Wonju, Gangwon-do, South Korea.
Kunda
K
Uma Maheswara Rao
Sim
S
Namkoong
Hwan-Chul
HC
Yu
Junsoo
J
Park
Chan-Moon
CM
Chung
Se Young
SY
Oh
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D055772:Green Chemistry Technology; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013997:Time Factors; D014465:Ultrasonics / Q000379:methods; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D063065:Organophosphonates; D014867:Water; D011092:Polyethylene Glycols
Cytotoxic activity; Di-α-aminophosphonates; Green synthesis