Fullerenols as a new therapeutic approach in nanomedicine.
Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases, and radiobiology. Some of the most widely used drugs in chemotherapy are anthracycline antibiotics. Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects. Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy. Additionally, due to the hollow spherical shape, fullerenols may be used as drug carriers. Moreover, because of the existence of the currently ineffective ways for neurodegenerative diseases treatment, alternative compounds, which could prevent the negative effects of oxidative stress in the brain, are still sought. In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.
Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.
Jacek
J
Grebowski
Paulina
P
Kazmierska
Anita
A
Krokosz
D018943:Anthracyclines / Q000009:adverse effects / Q000627:therapeutic use; D004337:Drug Carriers; D037741:Fullerenes / Q000627:therapeutic use*; D006801:Humans; D050997:Nanomedicine; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects; D014867:Water / Q000737:chemistry
D018943:Anthracyclines; D004337:Drug Carriers; D037741:Fullerenes; D014867:Water; C108127:fullerenol