Studies on the structure and physiology of salmon teleocalcin.
The structure and physiology of salmon teleocalcin, a Ca(+2) regulating hormone from the corpuscles of Stannius (CS) is reviewed. Teleocalcin is produced by the PAS+, type 1 cells in the CS. The hormone is a disulfide-linked homodimer, with a unique amino acid sequence and a carbohydrate moiety on residue 29. The teleocalcin monomer has a MW of 30 KD, whereas the pro-form of the monomer is 32 KD. The hormone is positively regulated by Ca(+2) and its function is to slow the active transport of Ca(+2) across the gill epithelium. In conjunction with prolactin, which stimulates Ca(+2) transport, teleocalcin is one of the major factors involved in Ca(+2) homeostasis in fish.
Department of Physiology, University of Manitoba, Faculty of Medicine, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada, R3E OW3.
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Wagner
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Friesen