[Influence of RGPU-207 compound and amiodarone on ion currents in shellfish neurons].
RGPU-207 compound and amiodarone in concentrations of 1, 10, 100 and 1000 microM produce dose-dependent and reversible effects on trans-membrane sodium, calcium, and potassium ion currents of neurons in pond snail and orb snail shellfish. In concentration of 1 microM, both compounds increased the amplitude of potassium ion currents, while not affecting the amplitude of sodium and calcium ion currents. In concentrations of 100 and 1000 microM, dose-dependent suppression of all currents (with predominant potassium ion current suppression) was observed. Under the action of RGPU-207 compound, the kinetics of activation and inactivation of sodium and calcium ion currents was not changed, but the kinetics of activation of the potassium slow current was slowing down. Amiodarone decelerated the inactivation of calcium ion current and accelerated the inactivation of potassium slow current. RGPU-207 compound, in comparison to amiodarone, produces a similar membranotropic effect on the shellfish neurons.
Iu D
IuD
Ignatov
I N
IN
Tiurenkov
A I
AI
Vislobokov
V N
VN
Perfilova
I S
IS
Mokrousov
D000085:Acetates / Q000494:pharmacology*; D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D017136:Ion Transport / Q000187:drug effects / Q000502:physiology; D008195:Lymnaea / Q000378:metabolism*; D049990:Membrane Transport Modulators / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010659:Phenylhydrazines / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*
C585025:(4-phenyl-2-pyrrolidon-1-yl)acetic acid phenylhydrazide; D000085:Acetates; D000889:Anti-Arrhythmia Agents; D049990:Membrane Transport Modulators; D010659:Phenylhydrazines; D011760:Pyrrolidinones; D012964:Sodium; D000638:Amiodarone; D002118:Calcium