High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia.
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p=0.01) and overall survival (p=0.04) and patients with low VLA-4 expression had shorter disease-free survival (p=0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.
Department of Laboratory Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, South Korea.
Sun-Young
SY
Ko
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea. Electronic address: cjpark@amc.seoul.kr.
Chan-Jeoung
CJ
Park
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Sang-Hyuk
SH
Park
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Young-Uk
YU
Cho
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Seongsoo
S
Jang
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Eul-Ju
EJ
Seo
Asan Institue for Life Sciences, Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Nayoung
N
Kim
Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Dae-Young
DY
Kim
Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Kyung Nam
KN
Koh
Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Ho Joon
HJ
Im
Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Jong-Jin
JJ
Seo
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Hyun-Sook
HS
Chi
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D019718:Receptors, CXCR4 / Q000378:metabolism*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055815:Young Adult
C527276:CXCR4 protein, human; D039041:Integrin alpha4beta1; D019718:Receptors, CXCR4
Acute lymphoblastic leukemia; Adult; CXCR4; Prognostic marker; Survival; VLA-4