Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas: is there an association?
OBJECTIVE
To report the coexistence of inflammatory hepatocellular adenoma (IHCA) and HNF1α-inactivated HCA (H-HCA) in cases from a multicentre study.


RESULTS
We report nine cases with the coexistence of IHCA and H-HCA; eight occurred in women, and one in a man. The numbers of nodules and the sizes of the largest and smallest HCAs were variable. In one case, the nodules of the two different subtypes were discovered at different times. In all women, HCAs were histologically typical, regardless of their subtype, whereas H-HCA in the man differed histologically from classic H-HCA.


CONCLUSIONS
These cases suggest that a predisposition to develop multiple adenomas, hypothetically caused by a 'benign tumorigenic field effect', although common to all HCAs, may result in different genotypes and phenotypes. Although this is rare, it is expected that more cases with the coexistence of different genotypes will emerge, owing to progress in the use of specific immunohistochemical approaches.
Service de Pathologie, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France; Inserm U1053, Université Bordeaux Segalen, Bordeaux, France.
Claire
C
Castain
Christine
C
Sempoux
Elizabeth M
EM
Brunt
Olivier
O
Causse
Anne
A
Heitzmann
Juan C
JC
Hernandez-Prera
Brigitte
B
Le Bail
Peter
P
Schirmacher
Swan N
SN
Thung
Charles
C
Balabaud
Paulette
P
Bioulac-Sage
D018248:Adenoma, Liver Cell / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor; D005260:Female; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha
hepatocellular adenoma subtypes; immunohistochemistry