[Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2].
Experiments have shown that GABA conjugate with prostaglandin E2 enhances cerebral blood flow in rats after global transient ischemia, while not affecting the cerebral hemoperfusion in intact animals. It is established that cerebrovascular activity of the GABA conjugate with prostaglandin E2 under conditions of cerebral ischemia is based on GABAergic mechanisms of vascular tone regulation, since it is removed by GABA(A)-receptor blocker bicuculline. At the same time, cerebral blood flow of intact rats and rats after global transient ischemia of brain is equally enhanced by prostaglandin E2 alone. This effect is not neutralized by bicuculline.
A V
AV
Gorbunova
T S
TS
Gan'shina
N M
NM
Gretskaia
V V
VV
Bezuglov
R S
RS
Mirzoian
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D008297:Male; D010120:Oxytocics / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D058787:GABA-A Receptor Antagonists; D010120:Oxytocics; D005680:gamma-Aminobutyric Acid; D015232:Dinoprostone; D001640:Bicuculline