Retinal nerve fiber layer thickness in normal Chinese students aged 6 to 17 years.
OBJECTIVE
We obtained retinal nerve fiber layer (RNFL) thickness measurements in normal Chinese students aged 6 to 17 years, and investigated the relationship between RNFL thickness and sex, eye laterality, age, axial length, and refractive error.


METHODS
A total of 4648 eyes in 2324 normal, randomly-selected Chinese students aged 6 to 17 years was examined in this study. The RNFL thickness was measured by optical coherence tomography. The effects of sex, eye laterality (left or right), age, refractive error, and axial length on RNFL thickness were assessed.


RESULTS
The average age of the subjects was 12.82 ± 3.11 years. The global average RNFL thickness (±SD) was 106.89 ± 12.84 μm. The thickest RNFL measurements were found at the superior (133.22 ± 19.48 μm) and inferior (129.23 ± 20.30 μm) quadrants of the retina, followed by the temporal (93.58 ± 29.15 μm) and nasal (77.10 ± 14.89 μm) quadrants. In the 1529 participants aged 12 to 17, there were no significant differences in RNFL thickness values between the right and left eyes (P > 0.05); significant differences in RNFL were found only in the inferior and temporal quadrants of the retina in different sex groups (P < 0.05). Linear regression analysis revealed that the RNFL thickness values were correlated independently with axial length and refractive error (P < 0.05).


CONCLUSIONS
For clinical assessment of RNFL thickness, the influence of refractive error and axial length should be taken into account.
Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Li
L
Chen
Jiannan
J
Huang
Haidong
H
Zou
Wenwen
W
Xue
Yingyan
Y
Ma
Xiangui
X
He
Lina
L
Lu
Jianfeng
J
Zhu
D000293:Adolescent; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D015995:Prevalence; D012016:Reference Values; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000453:epidemiology / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods*
Chinese; children; retinal nerve fiber layer; thickness