Sorbicillamines A-E, nitrogen-containing sorbicillinoids from the deep-sea-derived fungus Penicillium sp. F23-2.
Five new nitrogen-containing sorbicillinoids named sorbicillamines A-E (1-5) were isolated from an agitated culture of the deep-sea-derived fungus Penicillium sp. F23-2, which has previously produced indole alkaloids and terpenoids when cultured under static conditions. The structures of 1 to 5, including absolute configurations, were determined based on MS, NMR, and circular dichroism (CD) data. The cytotoxicities of the five new sorbicillin alkaloids against the HeLa, BEL-7402, HEK-293, HCT-116, and P388 cell lines were evaluated.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
Wenqiang
W
Guo
Jixing
J
Peng
Tianjiao
T
Zhu
Qianqun
Q
Gu
Robert A
RA
Keyzers
Dehai
D
Li
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D015394:Molecular Structure; D009584:Nitrogen / Q000032:analysis; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010407:Penicillium / Q000737:chemistry*; D012118:Resorcinols / Q000494:pharmacology
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D012118:Resorcinols; C473616:sorbicillin; D009584:Nitrogen