[NO-dependent mechanisms of cardioprotective activity of MT preparation during course administration to SHR rats].
Chronic (15 days) single daily intraperitoneal insertion of the new preparation MT (5 mg/kg) and metoprolol (10 mg/kg) into SHR rats leads to the same decrease (18%) in arterial pressure. In addition, MT exhibits a cardioprotective effect because of NO-mimetic properties, increasing NO formation in myocardium via increasing general NOS activity and eNOS expression. MT normalizes iNOS expression in myocardium mitochondria and decreases nitrotyrosine (nitrosation stress marker) formation. At the same time, the reference preparation metoprolol did not exhibit NO-mimetic properties in myocardium of SHR rats.
I S
IS
Chekman
I F
IF
Belenichev
L I
LI
Kucherenko
I A
IA
Mazur
E A
EA
Nagornaia
N V
NV
Bukhtiiarova
Iu A
IuA
Volchik
N V
NV
Parniuk
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D008790:Metoprolol / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology; D009569:Nitric Oxide / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis; D051381:Rats; D011918:Rats, Inbred SHR; D014230:Triazoles / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents; D014230:Triazoles; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D008790:Metoprolol; C533754:4-amino-1,2,4-triazole