Cohort profile: risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study.
OBJECTIVE
To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism.


METHODS
Between 2011 and 2012, 259 657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants.


RESULTS
The mean ± standard deviation (SD) age of this cohort was 57 ± 10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27).


CONCLUSIONS
The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259 657 adults from the general population across the China.
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Yufang
Y
Bi
Jieli
J
Lu
Weiqing
W
Wang
Yiming
Y
Mu
Jiajun
J
Zhao
Chao
C
Liu
Lulu
L
Chen
Lixin
L
Shi
Qiang
Q
Li
Qin
Q
Wan
Shengli
S
Wu
Tao
T
Yang
Li
L
Yan
Yan
Y
Liu
Guixia
G
Wang
Zuojie
Z
Luo
Xulei
X
Tang
Gang
G
Chen
Yanan
Y
Huo
Zhengnan
Z
Gao
Qing
Q
Su
Zhen
Z
Ye
Youming
Y
Wang
Guijun
G
Qin
Huacong
H
Deng
Xuefeng
X
Yu
Feixia
F
Shen
Li
L
Chen
Liebin
L
Zhao
Jie
J
Zhang
Jichao
J
Sun
Meng
M
Dai
Min
M
Xu
Yu
Y
Xu
Yuhong
Y
Chen
Shenghan
S
Lai
Zachary T
ZT
Bloomgarden
Donghui
D
Li
Guang
G
Ning
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology*; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D011634:Public Health / Q000379:methods / Q000706:statistics & numerical data; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data*; D012307:Risk Factors
D001786:Blood Glucose; D008055:Lipids
REACTION study; cancer; diabetes; 肿瘤，糖尿病，REACTION研究