[Impact of chronic prostatitis/chronic pelvic pain syndrome on sperm DNA fragmentation and nucleoprotein transition].
OBJECTIVE
To investigate the impact of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on sperm DNA fragmentation and nucleoprotein transition.


METHODS
Based on the recommended methods in the WHO Laboratory Manual for the Examination and Processing of Human Semen (5th ed), we conducted routine semen analysis for 65 CP/CPPS patients and 30 healthy men. We also analyzed the results of papanicolaou staining, sperm DNA fragmentation and sperm nucleoprotein transition.


RESULTS
Compared with the healthy control males, the CP/CPPS patients showed significant decreases in sperm concentration ([134.05 +/- 99.80] vs [94.75 +/- 92.07]) x 10(6)/ml, P <0.05), the percentage of morphologically normal sperm ([7.26 +/- 2.28] vs [5.61 +/- 3.40]%, P <0.05) and sperm progressive motility ([59.18 +/- 16.06] vs [47.68 +/- 17.62]%, P<0.05), but dramatic increases in sperm DNA fragmentation ([22.92 +/- 11.51] vs [43.58 +/- 17.07%, P<0.01) and sperm nucleoprotein transition ([23.26 +/- 5.97] vs [32.14 +/- 8.79]%, P<0.01).


CONCLUSIONS
CP/CPPS significantly reduces sperm quality and male fertility.
Center of Reproductive Medicine, The Second Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000, China. huyangyang0577@126.com
Yang-Yang
YY
Hu
Shun-Shun
SS
Cao
Jie-Qiang
JQ
Lü
D000328:Adult; D016022:Case-Control Studies; D053938:DNA Fragmentation; D006801:Humans; D008297:Male; D009698:Nucleoproteins / Q000235:genetics*; D011472:Prostatitis / Q000235:genetics*; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D055815:Young Adult
D009698:Nucleoproteins