Janus cyclic peptide-polymer nanotubes.
Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures. Here we report a new generation of self-assembled cyclic peptide-polymer nanotubes with dual functionality in the form of either a Janus or mixed polymeric corona. A 'relay' synthetic strategy is used to prepare nanotubes with a demixing or mixing polymeric corona. Nanotube structure is assessed in solution using (1)H-(1)H nuclear Overhauser effect spectroscopy NMR, and in bulk using differential scanning calorimetry. The Janus nanotubes form artificial pores in model phospholipid bilayers. These molecules provide a viable pathway for the development of intriguing nanotubular structures with dual functionality via a demixing or a mixing polymeric corona and may provide new avenues for the creation of synthetic transmembrane protein channel mimics.
Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney, Building F11, Sydney, New South Wales 2006, Australia.
Maarten
M
Danial
Carmen My-Nhi
CM
Tran
Philip G
PG
Young
Sébastien
S
Perrier
Katrina A
KA
Jolliffe