Serotonin 1A receptors and sexual behavior in male rats: a review.
Serotonin plays an important role in male sexual behavior. Many studies have been performed on the pivotal role of 5-HT₁A receptors in sexual behavior. Overall, 5-HT₁A receptors do not appear to be involved under normal circumstances, but become very important under conditions of elevated serotonin levels in sexual behavior. 5-HT₁A receptor agonists facilitate ejaculatory behavior in male rats, while inhibiting copulatory behavior. Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. Different mechanisms and brain regions are involved in these phases. The mechanisms, brain regions and the possible involvement of 5-HT and 5-HT₁A receptors in the appropriate phases in male rat sexual behavior will be discussed in the current review.
Department of Psychology, University of Tromsø, Tromsø, Norway. Electronic address: eelke.snoeren@uit.no.
Eelke M S
EM
Snoeren
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The Netherlands; Department of Anatomy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Jan G
JG
Veening
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The Netherlands.
Berend
B
Olivier
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The Netherlands.
Ronald S
RS
Oosting
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D003307:Copulation / Q000187:drug effects / Q000502:physiology; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*
D015306:Biogenic Monoamines; D058825:Serotonin 5-HT1 Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin
5-HT(1A) receptors; Animal models; Male; Serotonin; Sexual behavior