New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.
The methanol extract of the root cortex of Paeonia suffruticosa afforded two new monoterpene glycosides, paeoniside A (1) and paeoniside B (2), and three known monoterpene glycosides, paeoniflorin (3), benzoylpaeoniflorin (4) and 4-O-methyl-paeoniflorin (5). Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments. Compounds 1-5 were found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
a Zibo City Traditional Chinese Medicine Hospital , Shandong 255300 , China.
Xia
X
Zhu
Ze-Hai
ZH
Fang
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051545:Cyclooxygenase 1 / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D039821:Monoterpenes; C000591418:paeoniside A; C000591417:paeoniside B; C015423:peoniflorin; C047591:benzoylpaeoniflorin; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human