The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats.
This study investigated the effect of thiamine pyrophosphate on oxidative damage associated with cardiotoxicity caused by cisplatin (CIS), an antineoplastic agent, in rats, and compared this with thiamine. Animals used in the study were divided into four groups of 6 rats each. These represented a control group receiving 5 mg/kg of CIS, study groups receiving 20 mg/kg of thiamine pyrophosphate plus 5 mg/kg of cisplatin (CTPG) or 20 mg/kg of thiamine plus 5 mg/kg of cisplatin and a healthy (H) group. All doses were administered intraperitoneally once a day for 14 days. Malondialdehyde, total glutathione and products of DNA injury results were similar in the CTPG and H groups (p > 0.05). Creatinine kinase, creatine kinase MB and troponin 1 levels were similar in the CTPG and H groups (p > 0.05). Thiamine pyrophosphate prevented CIS-associated oxidative stress and heart injury, whereas thiamine did not prevent these.
Department of Cardiology, Numune State Hospital , Ankara , Turkey .
Resit
R
Coskun
Mehmet Ibrahim
MI
Turan
Isil Siltelioglu
IS
Turan
Mine
M
Gulapoglu
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D066126:Cardiotoxicity / Q000209:etiology / Q000517:prevention & control*; D002945:Cisplatin / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000494:pharmacology*; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D014803:Vitamin B Complex / Q000494:pharmacology
D000970:Antineoplastic Agents; D014803:Vitamin B Complex; D008315:Malondialdehyde; D005978:Glutathione; D002945:Cisplatin; D013835:Thiamine Pyrophosphate; D013831:Thiamine
Cisplatin; heart; rat; thiamine; toxicity