Exposure to bisphenol A affects lipid metabolism in Drosophila melanogaster.
Exposure to bisphenol A (BPA) in rodents was shown to induce obesity, yet the mechanism by which BPA might induce obesity is still unclear. We employed the genetically tractable model organism, Drosophila melanogaster, to test the effects of raising them on food containing various concentrations of BPA. Of note, raising males on food containing BPA were susceptible to starvation, possibly by inhibiting their ability to perform lipolysis during starvation, leading to significantly increased lipid content after 24 hr of fasting. Furthermore, feeding males with BPA significantly inhibited the expression of insulin-like peptides. From these results, we conclude that BPA may inhibit lipid recruitment during starvation in Drosophila.
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Michael J
MJ
Williams
Yi
Y
Wang
Anica
A
Klockars
P
P
Monica Lind
Robert
R
Fredriksson
Helgi B
HB
Schiöth
D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster; D005215:Fasting / Q000378:metabolism; D005260:Female; D007814:Larva; D050356:Lipid Metabolism / Q000187:drug effects*; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D010636:Phenols / Q000633:toxicity*; D013217:Starvation / Q000378:metabolism; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D029721:Drosophila Proteins; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds