Septic shock: on the importance of being tolerant.
A study by Figueiredo et al. (2013) in this issue of Immunity demonstrates that administration of anthracyclines induces autophagy in vivo and has a powerful protective effect in a mouse model of sepsis.
Howard Hughes Medical Institute, New Haven, CT 06510 USA; Yale University School of Medicine, New Haven, CT 06510 USA. Electronic address: ruslan.medzhitov@yale.edu.
Ruslan
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Medzhitov
D000818:Animals; D018943:Anthracyclines / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D064007:Ataxia Telangiectasia Mutated Proteins / Q000502:physiology; D004260:DNA Repair / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D010538:Peritonitis / Q000188:drug therapy*; D018805:Sepsis / Q000517:prevention & control*
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse