Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs.
The aim of present study was to reveal the toxicokinetic properties and absolute oral bioavailability of enniatin B1 in pigs. Five pigs were administered this Fusarium mycotoxin per os and intravenously in a two-way cross-over design. The toxicokinetic profile fitted a two-compartmental model. Enniatin B1 is rapidly absorbed after oral administration (T(1/2a)=0.15 h, Tmax=0.24h) and rapidly distributed and eliminated as well (T(1/2elα)=0.15 h; T(1/2elβ)=1.57 h). The absolute oral bioavailability is high (90.9%), indicating a clear systemic exposure. After intravenous administration, the mycotoxin is distributed and eliminated rapidly (T(1/2elα)=0.15 h; T(1/2elβ)=1.13 h), in accordance with oral administration.
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: mathias.devreese@ugent.be.
Mathias
M
Devreese
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Nathan
N
Broekaert
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Thomas
T
De Mil
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Sophie
S
Fraeyman
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Patrick
P
De Backer
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Siska
S
Croubels
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002853:Chromatography, Liquid; D047630:Depsipeptides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D005670:Fusarium / Q000737:chemistry*; D006207:Half-Life; D010865:Pilot Projects; D013552:Swine; D053719:Tandem Mass Spectrometry
D047630:Depsipeptides; C100264:enniatins
Absolute oral bioavailability; Enniatin B1; Mycotoxin; Pig; Toxicokinetics