Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease.
BACKGROUND
Patients with logopenic variant of primary progressive aphasia (lvPPA) display neuropathological differences from typical amnestic Alzheimer's disease (AD).


OBJECTIVE
The aim of the study was to compare cerebrospinal fluid (CSF) biomarker levels between patients with lvPPA due to AD (lvPPA-AD), non-logopenic forms of AD (nlAD), and amnestic mild cognitive impairment due to AD (aMCI-AD).


METHODS
CSF biomarker concentrations were assessed in 124 patients divided into three groups matched for age, level of education, center, and disease duration: lvPPA-AD (n = 30), nlAD (n = 67). and aMCI-AD (n = 27).


RESULTS
p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05). Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups.


CONCLUSIONS
These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD.
Research Memory Center (CMRR), CHU Besançon, Besançon, France.
Eloi
E
Magnin
Research Memory Center (CMRR) Paris-Nord-Ile-de France, AP-HP, Université Paris Diderot, Paris, France.
Claire
C
Paquet
Research Memory Center (CMRR), CHU Lyon, Lyon, France.
Maité
M
Formaglio
Research Memory Center (CMRR), CHU Lyon, Lyon, France.
Bernard
B
Croisile
Research Memory Center (CMRR), CHU Besançon, Besançon, France.
Ludivine
L
Chamard
Department of Biology, CHU Besançon, Besançon, France.
Carole
C
Miguet-Alfonsi
Research Memory Center (CMRR), CHU Besançon, Besançon, France.
Gregory
G
Tio
Research Memory Center (CMRR) Paris-Nord-Ile-de France, AP-HP, Université Paris Diderot, Paris, France.
Julien
J
Dumurgier
Research Memory Center (CMRR), CHU Lyon, Lyon, France.
Isabelle
I
Roullet-Solignac
Department of Neurology, CHU Nancy, Nancy, France.
Mathilde
M
Sauvée
Regional Memory Center (CMRR), CHU Saint-Etienne, Saint Priest en Jarez, France.
Catherine
C
Thomas-Antérion
Research Memory Center (CMRR), CHU Lyon, Lyon, France.
Alain
A
Vighetto
Research Memory Center (CMRR) Paris-Nord-Ile-de France, AP-HP, Université Paris Diderot, Paris, France.
Jacques
J
Hugon
Research Memory Center (CMRR), CHU Besançon, Besançon, France.
Pierre
P
Vandel
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D018888:Aphasia, Primary Progressive / Q000134:cerebrospinal fluid*; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D016011:Normal Distribution; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016875:tau Proteins
Alzheimer's disease; cerebrospinal fluid markers; logopenic; mild cognitive impairment; primary progressive aphasia