WormQTLHD--a web database for linking human disease to natural variation data in C. elegans.
Interactions between proteins are highly conserved across species. As a result, the molecular basis of multiple diseases affecting humans can be studied in model organisms that offer many alternative experimental opportunities. One such organism-Caenorhabditis elegans-has been used to produce much molecular quantitative genetics and systems biology data over the past decade. We present WormQTL(HD) (Human Disease), a database that quantitatively and systematically links expression Quantitative Trait Loci (eQTL) findings in C. elegans to gene-disease associations in man. WormQTL(HD), available online at http://www.wormqtl-hd.org, is a user-friendly set of tools to reveal functionally coherent, evolutionary conserved gene networks. These can be used to predict novel gene-to-gene associations and the functions of genes underlying the disease of interest. We created a new database that links C. elegans eQTL data sets to human diseases (34 337 gene-disease associations from OMIM, DGA, GWAS Central and NHGRI GWAS Catalogue) based on overlapping sets of orthologous genes associated to phenotypes in these two species. We utilized QTL results, high-throughput molecular phenotypes, classical phenotypes and genotype data covering different developmental stages and environments from WormQTL database. All software is available as open source, built on MOLGENIS and xQTL workbench.
Genomics Coordination Center, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands, Groningen Bioinformatics Center, University of Groningen, P.O. Box 11103, 9700 CC Groningen, The Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands, Department of Bioinformatics, Hanze University of Applied Sciences, Groningen, Zernikeplein 11, 9747 AS, The Netherlands and Laboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands.
K Joeri
KJ
van der Velde
Mark
M
de Haan
Konrad
K
Zych
Danny
D
Arends
L Basten
LB
Snoek
Jan E
JE
Kammenga
Ritsert C
RC
Jansen
Morris A
MA
Swertz
Yang
Y
Li
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D004195:Disease Models, Animal; D015870:Gene Expression; D014644:Genetic Variation; D049751:Genome, Helminth; D023281:Genomics; D006801:Humans; D020407:Internet; D009997:Osmotic Pressure; D010641:Phenotype; D040641:Quantitative Trait Loci