Increased incidence of serotype-1 invasive pneumococcal disease in young female adults in The Netherlands.
Analysis of the Dutch national invasive pneumococcal disease (IPD) surveillance data by sex reveals an increase in the incidence of serotype-1 disease in young female adults in The Netherlands after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the national immunization schedule. This has led to an overall increase in IPD in women aged 20-45 years, which was not observed in men of the same age. No other differences in serotype shifts possibly induced by the introduction of PCV7 were observed between the sexes in this age group. Serotype 1 is a naturally fluctuating serotype in Europe and it has been associated with disease in young healthy adults before. It remains uncertain whether or not there is an association between the observed increase in serotype-1 disease in young female adults and the implementation of PCV7 in The Netherlands.
St Antonius Hospital,Nieuwegein,The Netherlands.
S P
SP
Van Mens
University Medical Centre,Utrecht,The Netherlands.
A M M
AM
Van Deursen
St Antonius Hospital,Nieuwegein,The Netherlands.
S C A
SC
Meijvis
St Antonius Hospital,Nieuwegein,The Netherlands.
B J M
BJ
Vlaminckx
University Medical Centre,Utrecht,The Netherlands.
E A M
EA
Sanders
National Institute for Public Health and the Environment,Bilthoven,The Netherlands.
H E
HE
De Melker
National Institute for Public Health and the Environment,Bilthoven,The Netherlands.
L M
LM
Schouls
Academic Medical Centre, Amsterdam,The Netherlands.
A
A
Van Der Ende
National Institute for Public Health and the Environment,Bilthoven,The Netherlands.
S C
SC
De Greeff
St Antonius Hospital,Nieuwegein,The Netherlands.
G T
GT
Rijkers
D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*; D055815:Young Adult