Current therapeutic strategies and novel approaches in osteosarcoma.
Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies.
INSERM, UMR 957, 1 Rue Gaston Veil, 44035 Nantes, France. andokercgv@gmail.com.
Kosei
K
Ando
Marie-Françoise
MF
Heymann
Verena
V
Stresing
Kanji
K
Mori
Françoise
F
Rédini
Dominique
D
Heymann