Electrostatically driven complexation of liposomes with a star-shaped polyelectrolyte to low-toxicity multi-liposomal assemblies.
Anionic liposomes are electrostatically complexed to a star-shaped cationic polyelectrolyte. Upon complexation, the liposomes retain their integrity and the resulting liposome-star complexes do not dissociate in a physiological solution with 0.15 M NaCl. This provides a multi-liposomal container for possible use as a high-capacity carrier.
Lomonosov Moscow State University, Chemistry Department, Leninskie Gory 1-3, 119991, Moscow, Russia.
Alexander A
AA
Yaroslavov
Andrey V
AV
Sybachin
Olga V
OV
Zaborova
Dmitry V
DV
Pergushov
Alexander B
AB
Zezin
Nikolay S
NS
Melik-Nubarov
Felix A
FA
Plamper
Axel H E
AH
Müller
Frederic M
FM
Menger
D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry*; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000627:therapeutic use; D010743:Phospholipids / Q000737:chemistry; D055672:Static Electricity
D000838:Anions; D002412:Cations; D004573:Electrolytes; D008081:Liposomes; D010743:Phospholipids
drug delivery systems; liposomes; phospholipids; polyelectrolytes; star polymers