On the nature of interactions between ionic liquids and small amino-acid-based biomolecules.
During the last decade, ionic liquids (ILs) have revealed promising properties and applications in many research fields, including biotechnology and biological sciences. The focus of this contribution is to give a critical review of the phenomena observed and current knowledge of the interactions occurring on a molecular basis. As opposed to the huge advances made in understanding the properties of proteins in ILs, complementary investigations dealing with interactions between ILs and peptides or oligopeptides are underrepresented and are mostly only of phenomenological nature. However, the field has received more attention in the last few years. This Review features a meta-analysis of the available data and findings and should, therefore, provide a basis for a scientifically profound understanding of the nature and mechanisms of interactions between ILs and structured or nonstructured peptides. Fundamental aspects of the interactions between different peptides/oligopeptides and ILs are complemented by sections on the experimental (spectroscopy, structural biology) and theoretical (computational chemistry) possibilities to explain the phenomena reported so far in the literature. In effect, this should lead to the development of novel applications and support the understanding of IL-solute interactions in general.
Technische Universität Darmstadt, Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, 64287 Darmstadt, Fax.: +49 6151 16 72081. atietze@thielelab.de.
Alesia A
AA
Tietze
Frank
F
Bordusa
Ralf
R
Giernoth
Diana
D
Imhof
Thomas
T
Lenzer
Astrid
A
Maass
Carmen
C
Mrestani-Klaus
Ines
I
Neundorf
Kawon
K
Oum
Dirk
D
Reith
Annegret
A
Stark
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D052578:Ionic Liquids / Q000737:chemistry* / Q000378:metabolism; D007477:Ions / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D000596:Amino Acids; D052578:Ionic Liquids; D007477:Ions; D010455:Peptides
amino acids; interactions; ionic liquids; peptides; proteins