title: Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway.
abstract: Functional intracellular Ca(2+) signaling is essential for the upregulation of the canonical mTOR-controlled autophagy pathway triggered by rapamycin or by nutrient deprivation. Moreover, modifications in the Ca(2+)-signaling machinery coincide with autophagy stimulation. This results in enhanced intracellular Ca(2+) signaling essential for driving the autophagy process. Yet, the mechanisms upstream (the players causing the changes in Ca(2+) signaling) and downstream (the targets of the altered Ca(2+) signals) of this Ca(2+)-dependent autophagy pathway remain elusive. Here, we speculate about these mechanisms based on our current knowledge.
authors.affiliation: Laboratory of Molecular and Cellular Signaling; Department of Cellular and Molecular Medicine; KU Leuven; Leuven, Belgium ; Current affiliation: Laboratory of Abdominal Transplant Surgery; Department of Microbiology and Immunology; University Hospitals Leuven; KU Leuven; Leuven, Belgium.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Decuypere
authors.forename: Ram Chandra
authors.initials: RC
authors.lastname: Paudel
authors.forename: Jan
authors.initials: J
authors.lastname: Parys
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
keywords: Beclin 1; Ca2+ signaling; autophagosomes; autophagy; endoplasmic reticulum; inositol 1,4,5-trisphosphate receptor; mTOR