title: Long non-coding RNAs in pluripotent stem cell biology.
abstract: Pluripotent stem cells are defined by their unlimited self-renewal capacities and potential to differentiate into any cell lineage. Many crucial determinants for the induction and maintenance of this pluripotent state have been identified. Long non-coding RNAs have recently emerged as key regulators of pluripotent stem cells and have enhanced our understanding of their potential functions in tissue regeneration. This review provides an overview of recent important insights into the roles of long non-coding RNAs as regulators and markers of pluripotency.
authors.affiliation: a Department of Pediatric Hematology-Oncology and Stem Cell Transplantation , Ghent University Hospital, 3K12D , De Pintelaan 185, 9000 Ghent , Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Lammens
authors.forename: Inge
authors.initials: I
authors.lastname: D'hont
authors.forename: Katharina
authors.initials: K
authors.lastname: D'Herde
authors.forename: Yves
authors.initials: Y
authors.lastname: Benoit
authors.forename: Araceli
authors.initials: A
authors.lastname: Diez-Fraile
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000502:physiology*; D062085:RNA, Long Noncoding / Q000502:physiology*
chemical_list: D062085:RNA, Long Noncoding