title: [Study of the visual deficits pattern in strabismic and anisometropic amblyopia].
abstract: OBJECTIVE
  To elucidate the difference in the pathogenesis between strabismic and anisometropic amblyopia.
  
  
  METHODS
  It was a case-control study.We used psychophysical methods, including grating acuity, edge contrast sensitivity, contrast sensitivity function tests, and examined the visual functions of 150 cases from 8 to 40-year-old. Then we applied the Origin 8.0 software for statistical analysis of experimental data, we did the correlation analysis between the grating acuity, edge contrast sensitivity and optotype acuity, and the similarity comparison of the contrast sensitivity function curve between the strabismic and anisometropic amblyopia.
  
  
  RESULTS
  The grating acuity had a strong correlation with optotype acuity, the correlation value was 0.81. The grating acuity of the strabismic group was roughly 15% lower than the whole abnormal population, for any given level of optotype acuity; the edge contrast threshold had a weak correlation with optotype acuity, the correlation value was 0.24. Anisometropia, for a given level of optotype acuity, had edge contrast thresholds that were 15% higher (worse) than the whole population, while strabismic and strabismic-anisometropia had edge contrast thresholds that are 17% lower (better) than the whole population. The CSF of all amblyopic eyes were reduced in comparison with the non-amblyopic eye of the same person, the peak sensitivity shifted toward to the low spatial frequency region, the CS curve was depressed especially in the middle and high spatial frequencies, there were no significant difference, but at low frequency area(1.0 c/d) there were statistically significant between the two types of amblyopia(t = 2.239, P < 0.05).
  
  
  CONCLUSIONS
  There were differences in the patterns of visual loss between strabismic and anisometropic amblyopic patients.
authors.affiliation: Eye Center, Affiliated Second Hospital, Zhejiang University, Hangzhou 310009, China.
authors.forename: Jing-wen
authors.initials: JW
authors.lastname: Gong
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Sun
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Wang
authors.forename: Xing-chao
authors.initials: XC
authors.lastname: Shentu
authors.forename: Feng-wei
authors.initials: FW
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000503:physiopathology*; D015858:Anisometropia / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D015350:Contrast Sensitivity; D003867:Depth Perception; D005260:Female; D006801:Humans; D008297:Male; D013285:Strabismus / Q000503:physiopathology*; D014792:Visual Acuity; D055815:Young Adult