title: Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience.
abstract: OBJECTIVE
  We performed a single center analysis of 60 adult patients (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HCT) at our institution.
  
  
  RESULTS
  Allogeneic stem cell in patients were transplanted between 1988 and 2010, 28 had an human leukocyte antigen (HLA)-identical sibling donor, 23 had an HLA-identical unrelated donor, and 9 had an 1 allele mismatched donor. The median age at time of HCT was 44 (range: 18-68) years. Conditioning therapy was myeloablative in 36 patients and consisted of a reduced-intensity conditioning (RIC) regimen in 24 patients. Graft-versus-host disease (GvHD) prophylaxis was performed with a combination of methotrexate and cyclosporine A in 36 patients, and cyclosporine A plus mycophenolate mofetil in 24 patients. The 10-year probability of overall survival was 46 %.
  
  
  CONCLUSIONS
  In a multivariate analysis, we identified pretransplantation serum ferritin as the only independent adverse prognostic variable predicting survival in our patients.
authors.affiliation: Department of Internal Medicine I, Bone Marrow Transplantation Unit, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Boehm
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Sperr
authors.forename: Peter
authors.initials: P
authors.lastname: Kalhs
authors.forename: Hildegard
authors.initials: H
authors.lastname: Greinix
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
authors.forename: Nina
authors.initials: N
authors.lastname: Worel
authors.forename: Alexander
authors.initials: A
authors.lastname: Kainz
authors.forename: Margit
authors.initials: M
authors.lastname: Mitterbauer
authors.forename: Marija
authors.initials: M
authors.lastname: Bojic
authors.forename: Werner
authors.initials: W
authors.lastname: Rabitsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000601:surgery*; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome