title: A chronological expression profile of gene activity during embryonic mouse brain development.
abstract: The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning, we conducted detailed transcriptional profiling during embryonic development of the mouse brain. A total of 2,400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. A significant group of novel genes of as yet undiscovered biological function were detected as being potentially relevant to brain development and function, in addition to genes that have previously identified roles in the brain. Furthermore, analysis for genes that display asymmetric expression between the left and right brain hemispheres during development revealed 35 genes as putatively asymmetric from a combined data set. Our data constitute a valuable new resource for neuroscience and neurodevelopment, exposing possible functional associations between genes, including novel loci, and encouraging their further investigation in human neurological and behavioural disorders.
authors.affiliation: Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK, p.goggolidou@har.mrc.ac.uk.
authors.forename: P
authors.initials: P
authors.lastname: Goggolidou
authors.forename: S
authors.initials: S
authors.lastname: Soneji
authors.forename: N
authors.initials: N
authors.lastname: Powles-Glover
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: S
authors.initials: S
authors.lastname: Sethi
authors.forename: D
authors.initials: D
authors.lastname: Baban
authors.forename: M M
authors.initials: MM
authors.lastname: Simon
authors.forename: I
authors.initials: I
authors.lastname: Ragoussis
authors.forename: D P
authors.initials: DP
authors.lastname: Norris
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D008809:Mice, Inbred C3H