title: [Effects of physical stimulation of spontaneous arteriolar vasomotion on microcirculation and the immune system in diabetes and impaired wound healing].
abstract: BACKGROUND
  Whether and to what extent the complementary use of a biorhythm-defined physical stimulation of insufficient spontaneous arteriolar vasomotion contributes to increasing the therapeutic success of established treatment concepts were examined.
  
  
  METHODS
  In a placebo-controlled study on a biometrically defined sample of older diabetes patients with impaired wound healing, measurements of representative features of the functional status of the microcirculation and the immune system were investigated using high-resolution methods (intravital microscopy, reflective spectrometry, white light spectroscopy combined with laser Doppler microflow measurements). The stimulation signal corresponding to physiological spontaneous arteriolar vasomotion was transmitted using an electromagnetic alternating field of low magnetic flux density.
  
  
  RESULTS
  During the 27-day treatment and observation period, a complementary treatment effect of the applied biorhythm-defined physical vasomotion stimulation could be detected.
authors.affiliation: Institut für Mikrozirkulation, Berliner Str. 25, 16321, Bernau bei Berlin, Deutschland, imzber@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Klopp
authors.forename: J
authors.initials: J
authors.lastname: Schulz
authors.forename: W
authors.initials: W
authors.lastname: Niemer
authors.forename: K J
authors.initials: KJ
authors.lastname: Ruhnau
mesh_terms: D000368:Aged; D001160:Arterioles / Q000276:immunology*; D001783:Blood Flow Velocity / Q000276:immunology; D003131:Combined Modality Therapy / Q000379:methods; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000276:immunology*; D026201:Musculoskeletal Manipulations / Q000379:methods; D010812:Physical Stimulation / Q000379:methods; D015990:Placebo Effect; D016896:Treatment Outcome; D014945:Wound Healing / Q000276:immunology*