title: Au(III)/TPPMS-catalyzed benzylation of indoles with benzylic alcohols in water.
abstract: A novel and efficient method for the Au(III)/TPPMS-catalyzed direct substitution reaction of benzhydryl and benzylic alcohols with indoles in water is developed. Au(III)/TPPMS is an effective catalyst for the benzylation of the strong π nucleophile 1-methylindole, while common Brønsted or Lewis acids are ineffective.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University , 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Hikawa
authors.forename: Hideharu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Isao
authors.initials: I
authors.lastname: Azumaya
mesh_terms: D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D007211:Indoles; D009943:Organophosphorus Compounds; D013451:Sulfonic Acids; D014867:Water; D006046:Gold