title: Naked replication forks break apRPArt.
abstract: Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin and treatment of cancers with high levels of replicative stress.
authors.affiliation: Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: ofernandez@cnio.es.
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernandez-Capetillo
authors.forename: André
authors.initials: A
authors.lastname: Nussenzweig
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D051716:Replication Protein A / Q000378:metabolism*
chemical_list: C497167:RPA1 protein, human; D051716:Replication Protein A; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins