title: Candida glabrata: a review of its features and resistance.
abstract: Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.
authors.affiliation: IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.
authors.forename: C F
authors.initials: CF
authors.lastname: Rodrigues
authors.forename: S
authors.initials: S
authors.lastname: Silva
authors.forename: M
authors.initials: M
authors.lastname: Henriques
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000502:physiology*; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D025141:Drug Resistance, Fungal; D006801:Humans
chemical_list: D000935:Antifungal Agents