title: Synthesis of 1,2,3-triazolyl nucleoside analogs as potential anti-influenza A (H3N2 subtype) virus agents.
abstract: Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).
authors.affiliation: Unité de Chimie Biomoléculaire et Médicinale, Laboratoire de Chimie Biomoléculaire Substances Naturelles et Réactivité (URAC 16), Faculty of Science Semlalia, Marrakech, Morocco.
authors.forename: Hanane
authors.initials: H
authors.lastname: Elayadi
authors.forename: Michael
authors.initials: M
authors.lastname: Smietana
authors.forename: Jean J
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Hassan B
authors.initials: HB
authors.lastname: Lazrek
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002415:Cats; D002522:Chlorocebus aethiops; D004285:Dogs; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000254:growth & development; D061985:Madin Darby Canine Kidney Cells; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D014230:Triazoles
keywords: 1,2,3-Triazolyl nucleoside; Anti-influenza A (H3N2); Click reaction