title: Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1α expression.
abstract: To clarify the mechanism of action of an intravenous immunoglobulin (IVIG) preparation in chronic inflammatory demyelinating polyneuropathy, the effects of IVIG were investigated using an experimental autoimmune neuropathy model in the rat. IVIG significantly suppressed the progression of neurologic signs and sciatic nerve conduction velocity with the inhibition of inflammatory cell infiltration, mainly of macrophages, to the peripheral nerves. A significant suppressive effect on the expression of macrophage inflammatory protein 1-α (MIP-1α) was simultaneously observed in the nerves. These results suggest that IVIG is effective for inflammatory demyelinating polyneuropathy by inhibiting the chemotactic factor of macrophages.
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan. Electronic address: kajii-masahiko@jbpo.or.jp.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kajii
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Fujio
authors.initials: F
authors.lastname: Kobayashi
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kashihara
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuuki
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Kubo
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakae
authors.affiliation: Central Research Laboratory, Japan Blood Products Organization, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Kamizono
authors.affiliation: Department of Neurology, Kinki University School of Medicine, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kuzumoto
authors.affiliation: Department of Neurology, Kinki University School of Medicine, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D017252:CD3 Complex; D002135:Calcium-Binding Proteins / Q000378:metabolism; D054405:Chemokine CCL3 / Q000235:genetics / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000633:toxicity; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D009186:Myelin Sheath / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D011930:Reaction Time / Q000187:drug effects; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors
chemical_list: C100745:Aif1 protein, rat; D017252:CD3 Complex; D002135:Calcium-Binding Proteins; D054405:Chemokine CCL3; D018925:Chemokines; D016756:Immunoglobulins, Intravenous; D008840:Microfilament Proteins; D012333:RNA, Messenger; D005620:Freund's Adjuvant
keywords: Chronic inflammatory demyelinating polyneuropathy (CIDP); Experimental autoimmune neuritis (EAN); Intravenous immunoglobulin preparation (IVIG); Macrophage inflammatory protein-1α (MIP-1α)