title: [Danhong injection, ligustrazine injection, combined adsorbable biomembranes prevented adhesion of tendons after the repair operation: a clinical research].
abstract: OBJECTIVE
  To explore the effect and the mechanism of Danhong Injection (DI), Ligustrazine Injection (LI), and adsorbable biomembranes in preventing the adhesion of tendons and tissues.
  
  
  METHODS
  Totally 120 patients all suffering from simple flexor digitorum tendon rupture on the hand zone two damaged by sharp weapons were randomly assigned to Group A (Dikang adsorbable biomembrane), Group B (Tianxinfu adsorbable biomembrane), Group C (Tianxinfu adsorbable biomembrane + Ligustrazine group), and Group D (Tianxinfu adsorbable biomembrane + DI group) in accordance with random digit table, 30 cases in each group. Indicators such as total active movement (TAM) of the hand tendon, Minnesota manual dexterity test (MMDT), and finger flex strength test (FFST) were observed.
  
  
  RESULTS
  The TAM and the favorable rate were higher in Group C and D than in Group A and B at post-operative 4 and 8 week (P < 0.05, P < 0.01). There was no statistical difference between Group C and D (P > 0.05). Each index of MMDT was lower in Group C and D than in Group A and B (P < 0.05). There was no statistical difference in FFST among all the 4 groups (P > 0.05).
  
  
  CONCLUSIONS
  Combined application of LI or DI with Tianxinfu adsorbable biomembranes could effectively prevent the adhesion of tendons. DI showed equivalent effect as LI did. Besides, the combined application was superior in preventing adhesion to using Xintianfu adsorbable biomembrane or Dikan adsorbable biomembrane alone.
authors.affiliation: Luoyang Orthopedics Hospital, Henan 471002, China. zhaozhiwei999@126.com
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Cheng
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Ma
authors.forename: Hai-Min
authors.initials: HM
authors.lastname: Shan
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Cheng
authors.forename: Guan-Peng
authors.initials: GP
authors.lastname: Song
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000517:prevention & control*; D011719:Pyrazines / Q000008:administration & dosage / Q000627:therapeutic use*; D013708:Tendon Injuries / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D004365:Drugs, Chinese Herbal; D008567:Membranes, Artificial; D011719:Pyrazines; C540581:danhong; C017953:tetramethylpyrazine