title: Molecular basis of recovering on mechanical circulatory support.
abstract: Our insights into different system levels of mechanisms by left ventricular assist device support are increasing and suggest a complex regulatory system of overlapping biological processes. To develop novel decision-making strategies and patient selection criteria, heart failure and reverse cardiac remodeling should be conceptualized and explored by a multifaceted research strategy of transcriptomics, metabolomics, proteomics, molecular biology, and bioinformatics. Knowledge of the molecular mechanisms of reverse cardiac remodeling is in its early stages, and comprehensive reconstruction of the underlying networks is necessary.
authors.affiliation: University of California, Ahmanson-UCLA Cardiomyopathy Center, 100 Medical Plaza, Suite 630, Los Angeles, CA 90095, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Nsair
authors.forename: David A
authors.initials: DA
authors.lastname: Liem
authors.forename: Martin
authors.initials: M
authors.lastname: Cadeiras
authors.forename: Richard K
authors.initials: RK
authors.lastname: Cheng
authors.forename: Mrudula
authors.initials: M
authors.lastname: Allareddy
authors.forename: Murray
authors.initials: M
authors.lastname: Kwon
authors.forename: Richard
authors.initials: R
authors.lastname: Shemin
authors.forename: Mario C
authors.initials: MC
authors.lastname: Deng
mesh_terms: D003657:Decision Making; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D018579:Patient Selection; D020257:Ventricular Remodeling
keywords: Advanced heart failure; Mechanical circulatory support; Molecular mechanisms; Reverse remodeling