title: Pulchranins B and C, new acyclic guanidine alkaloids from the Far-Eastern marine sponge Monanchora pulchra.
abstract: New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 microM, respectively) and less potent against TRPV3 and TRPA1 receptors.
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia. makarieva@piboc.dvo.ru
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: Ekaterina K
authors.initials: EK
authors.lastname: Ogurtsova
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Korolkova
authors.forename: Yaroslav A
authors.initials: YA
authors.lastname: Andreev
authors.forename: Irina V
authors.initials: IV
authors.lastname: Mosharova
authors.forename: Ksenya M
authors.initials: KM
authors.lastname: Tabakmakher
authors.forename: Alla G
authors.initials: AG
authors.lastname: Guzii
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Eugene V
authors.initials: EV
authors.lastname: Grishin
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010140:Pacific Ocean; D011161:Porifera / Q000737:chemistry*; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors*
chemical_list: D000470:Alkaloids; D006146:Guanidines; D050916:TRPV Cation Channels; C585669:pulchranin B; C585670:pulchranin C