title: Evaluation of submandibular versus labial salivary gland fibrosis in IgG4-related disease.
abstract: The newly comprehensive diagnostic criteria in 2011 emphasize the importance of IgG4-positive plasmacyte infiltration along with storiform or swirling fibrosis and obliterative phlebitis in diagnosing IgG4-related disease(RD). Although labial salivary gland (LSG) biopsy is a minimally invasive and convenient procedure for obtaining tissues, LSG fibrosis is thought to be inconspicuous or absent in IgG4-RD cases. In this study we evaluated 15 patients with IgG4-RD, in whom both submandibular gland (SMG) and LSG biopsies were performed at the same time. Histological evaluation revealed fibrosis in all the SMG specimens but in only one LSG specimen (6.7%). The diagnosis of IgG4-RD is primarily based on its morphological appearance on biopsy. The results of this study demonstrated that although more invasive than LSG biopsy, SMG biopsy is recommended for accurate diagnosis of IgG4-related MD and to exclude malignant diseases.
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine , Sapporo , Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takano
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Keira
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Seki
authors.forename: Ayumi
authors.initials: A
authors.lastname: Abe
authors.forename: Motohisa
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G; D007249:Inflammation / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012470:Salivary Glands, Minor / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4-related disease; Mikuicz's disease; Salivary gland biopsy; Salivary gland fibrosis