title: Time course of CD marker expression in patients with burns and its prognostic value.
abstract: BACKGROUND
  Due to immune suppression sepsis has remained the leading cause of mortality after burns. CD marker expression in circulating blood has not been fully examined in humans. The aim of our study was to asses CD marker expression after burns and to compare it between survivors and non-survivors.
  
  
  METHODS
  Blood samples from all patients (n = 35) receiving intensive care treatment with more than 20% burned surface area were collected on admission and 5 consecutive days thereafter. Expressions of CD11a, CD11b, CD18, CD49d, CD97 and CD14 were measured on granulocytes, lymphocytes and monocytes.
  
  
  RESULTS
  Expressions of granulocytes CD11a (days 1-2), CD18 (day 1), lymphocytes CD11a (days 1-5), CD11b (days 2-4), CD18 (days 1-6), CD49d (days 1-6), CD97 (day 1), monocytes CD11a (days 1-6), CD11b (day 2 and 5-6), CD18 (days 1-6), CD49d (days 1-6), CD97 (days 1-2), and CD14 (days 4-6) were significantly lower in patients than in healthy controls. Expressions of granulocyte CD11a (days 3-6), lymphocytes CD11a (days 3-6), CD11b (days 4-6), CD18 (days 4-6), monocyte CD97 (days 3-6) were significantly higher in survivors (n = 20) than in non-survivors (n = 15).
  
  
  CONCLUSIONS
  These results suggest that burns is associated with immunosuppression and overwhelming anti-inflammatory processes may be signs of bad prognosis.
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Hungary. Electronic address: szelig.livia@chello.hu.
authors.forename: Livia
authors.initials: L
authors.lastname: Szelig
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Hungary.
authors.forename: Szilard
authors.initials: S
authors.lastname: Rendeki
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Hungary.
authors.forename: Viktor
authors.initials: V
authors.lastname: Foldi
authors.affiliation: Department of Surgical Research and Techniques, Faculty of Medicine, University of Pécs, Hungary.
authors.forename: Janos
authors.initials: J
authors.lastname: Lantos
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Bogar
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Csontos
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology* / Q000378:metabolism; D002056:Burns / Q000276:immunology* / Q000378:metabolism / Q000401:mortality; D040881:CD11a Antigen / Q000276:immunology / Q000378:metabolism; D039481:CD11b Antigen / Q000276:immunology / Q000378:metabolism; D018821:CD18 Antigens / Q000276:immunology / Q000378:metabolism; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006098:Granulocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D039441:Integrin alpha4 / Q000276:immunology / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000276:immunology / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D011379:Prognosis; D011446:Prospective Studies; D043562:Receptors, G-Protein-Coupled; D015996:Survival Rate
chemical_list: C095004:ADGRE5 protein, human; D015703:Antigens, CD; D040881:CD11a Antigen; D039481:CD11b Antigen; D018821:CD18 Antigens; C509295:ITGAM protein, human; D018950:Lipopolysaccharide Receptors; D043562:Receptors, G-Protein-Coupled; D039441:Integrin alpha4
keywords: Burns; Leucocyte cell surface markers; Sepsis