title: Nonmydriatic ultra-wide-field scanning laser ophthalmoscopy (Optomap) versus two-field fundus photography in diabetic retinopathy.
abstract: The purpose of this study was to investigate the diagnostic properties of a 2-laser wavelength nonmydriatic 200° ultra-wide-field scanning laser ophthalmoscope (SLO) versus mydriatic 2-field 45° color fundus photography (EURODIAB standard) for assessing diabetic retinopathy (DR). A total of 143 consecutive eyes of patients with different levels of DR were graded regarding DR level and macular edema based on 2-field color photographs or 1 Optomap Panoramic 200 SLO image. All SLO images were nonmydriatic and all photographs mydriatic. Grading was performed masked to patient and clinical data. Based on photography, 20 eyes had no DR, 44 had mild, 18 moderate and 42 severe nonproliferative DR, and 19 eyes had proliferative DR. Overall correlation for grading DR level compared to Optomap SLO was moderate with kappa 0.54 (p < 0.001), fair-to-moderate in macular edema grading with kappa 0.39 (p < 0.001), and substantial for grading clinically significant macular edema (kappa 0.77). The wide-field SLO offers a wider field of view and can potentially better differentiate lesions by applying the 2 laser wavelengths. However, these advantages over 2-field fundus photography need to be confirmed in further studies.
authors.affiliation: Department of Ophthalmology, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Raffael
authors.initials: R
authors.lastname: Liegl
authors.forename: Kristine
authors.initials: K
authors.lastname: Liegl
authors.forename: Lala
authors.initials: L
authors.lastname: Ceklic
authors.forename: Christos
authors.initials: C
authors.lastname: Haritoglou
authors.forename: Anselm
authors.initials: A
authors.lastname: Kampik
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ulbig
authors.forename: Marcus
authors.initials: M
authors.lastname: Kernt
authors.forename: Aljoscha S
authors.initials: AS
authors.lastname: Neubauer
mesh_terms: D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D005654:Fundus Oculi; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007332:Insulin Infusion Systems; D007834:Lasers; D008269:Macular Edema / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D010781:Photography / Q000379:methods*; D014794:Visual Fields; D055815:Young Adult
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human