title: Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.
abstract: Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.
authors.affiliation: Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Nam
authors.forename: Eui-Kyung
authors.initials: EK
authors.lastname: Hwang
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jin
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Yoo-Seob
authors.initials: YS
authors.lastname: Shin
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Ye
authors.forename: Arantxa
authors.initials: A
authors.lastname: Palacin
authors.forename: Gabriel
authors.initials: G
authors.lastname: Salcedo
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology*; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D010641:Phenotype; D014908:Triticum / Q000276:immunology; D014581:Urticaria / Q000276:immunology; D021182:Wheat Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D052179:Antigens, Plant; D015415:Biomarkers; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C550251:Tri a 14 allergen, Triticum aestivum; D007073:Immunoglobulin E; D005903:Gliadin
keywords: Baker's Asthma; Gliadin; Lipid Transfer Protein; Wheat