title: HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes.
abstract: HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)-α and interferon (IFN)-γ production by total and Vγ9Vδ2 T cells in vitro. Tat clade B, but not C, augmented TNF-α production by THP-1 cells. However, Tat clades A-D did not affect TNF-α or IFN-γ production or secretion by resting or activated conventional and Vγ9Vδ2 T cells. Therefore, transactivation of cytokines by Tat is immune cell-specific.
authors.affiliation: aDepartment of Pharmacology and Therapeutics bDepartment of Immunology, School of Medicine, Trinity College Dublin, Ireland.
authors.forename: Alan
authors.initials: A
authors.lastname: Kennedy
authors.forename: Andreea
authors.initials: A
authors.lastname: Petrasca
authors.forename: Derek G
authors.initials: DG
authors.lastname: Doherty
authors.forename: Martina
authors.initials: M
authors.lastname: Hennessy
authors.forename: J Paul
authors.initials: JP
authors.lastname: Spiers
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology*; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
chemical_list: D016207:Cytokines; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054322:tat Gene Products, Human Immunodeficiency Virus