title: Anti-inflammatory properties of Streptococcus salivarius, a commensal bacterium of the oral cavity and digestive tract.
abstract: Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius, suggesting a protective response exclusively with metabolically active bacteria.
authors.affiliation: INRA, UMR1319 Micalis, Jouy-en-Josas, France.
authors.forename: Ghalia
authors.initials: G
authors.lastname: Kaci
authors.forename: Denise
authors.initials: D
authors.lastname: Goudercourt
authors.forename: Véronique
authors.initials: V
authors.lastname: Dennin
authors.forename: Bruno
authors.initials: B
authors.lastname: Pot
authors.forename: Joël
authors.initials: J
authors.lastname: Doré
authors.forename: S Dusko
authors.initials: SD
authors.lastname: Ehrlich
authors.forename: Pierre
authors.initials: P
authors.lastname: Renault
authors.forename: Hervé M
authors.initials: HM
authors.lastname: Blottière
authors.forename: Catherine
authors.initials: C
authors.lastname: Daniel
authors.forename: Christine
authors.initials: C
authors.lastname: Delorme
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D003092:Colitis / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000276:immunology / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000382:microbiology; D051379:Mice; D009055:Mouth / Q000382:microbiology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology; D013291:Streptococcus / Q000276:immunology* / Q000502:physiology*; D013559:Symbiosis
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B