title: Left ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study.
abstract: We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by ≥2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n=24), patients with DAN (n=35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1%±8.2% vs 26.5%±5.1%; P=.031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8±6.3 vs 69.3±3.3 bpm; P<.0001) and a higher rest LV workload (10,072±1165 vs 8606±1075 bpm mm Hg; P<.0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A/V index, and a higher LV working load than non-DAN patients.
authors.affiliation: First Propeudetic Department of Internal Medicine, Diabetes Center, Medical School, Aristotle University of Thessaloniki, "AHEPA'' Hospital, Thessaloniki, Greece didang@med.auth.gr.
authors.forename: Triantafyllos P
authors.initials: TP
authors.lastname: Didangelos
authors.affiliation: Laboratory of Nuclear Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Arsos
authors.affiliation: Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Karamitsos
authors.affiliation: First Propeudetic Department of Internal Medicine, Diabetes Center, Medical School, Aristotle University of Thessaloniki, "AHEPA'' Hospital, Thessaloniki, Greece.
authors.forename: Fotios
authors.initials: F
authors.lastname: Iliadis
authors.affiliation: Second Propeudetic Department of Internal Medicine Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Papageorgiou
authors.affiliation: Laboratory of Nuclear Medicine, Medical School, Aristotle University of Thessaloniki, "AHEPA" Hospital, Thessaloniki, Greece.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Moralidis
authors.affiliation: Second Propeudetic Department of Internal Medicine Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Athyros
mesh_terms: D002302:Cardiac Output; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging*; D003971:Diastole / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D015635:Radionuclide Ventriculography / Q000379:methods*; D013599:Systole / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: autonomic neuropathy; diabetes mellitus; left ventricular function; radionuclide ventriculography