title: The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease.
abstract: Netrins are a family of proteins involved in cell migration and axon guidance during embryogenesis. The different functions and mechanisms of action of this family of proteins have been better characterized with the study of netrin-1. They are chemotropic and act as a bifunctional regulator of neuron migration. Apart from its role in the central nervous system, researchers have proven that netrin-1 plays a role in the development and formation of non-neural tissue; netrin-1 is thereby involved in regulation of cancers, cardiovascular diseases, kidney diseases, and other diseases. Concerning the cardiovascular realm, netrin-1 promotes angiogenesis and accelerates atherosclerosis, protects the heart against ischemia-reperfusion injury, and reduces the infarct size. These findings make the neuroimmune guidance cue netrin-1 an important therapeutic target. This work seeks to review the subject based on studies that have been conducted over the past decade to identify the perspectives and extent of the research on this protein in the field of cardiology.
authors.affiliation: Department of cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Joseph Bertrand
authors.initials: JB
authors.lastname: Bongo
authors.affiliation: Department of cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: pengdq@hotmail.com.
authors.forename: Dao Quan
authors.initials: DQ
authors.lastname: Peng
mesh_terms: D050197:Atherosclerosis / Q000235:genetics; D002316:Cardiotonic Agents; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009389:Neovascularization, Pathologic / Q000235:genetics; D009414:Nerve Growth Factors / Q000009:adverse effects* / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D000075388:Netrin-1; D025521:Tumor Suppressor Proteins / Q000009:adverse effects* / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D002316:Cardiotonic Agents; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1
keywords: Angiogenesis; Atherosclerosis; Cardioprotection; Ischemia–reperfusion injury; Netrin-1