title: Update on endocrine and metabolic therapy-related late effects observed in survivors of childhood neoplasia.
abstract: OBJECTIVE
  To provide a summary of the most recent research pertaining to the endocrine and metabolic complications observed in childhood cancer survivors.
  
  
  RESULTS
  Data on prevalence and risk associations are increasingly available from large cohorts of childhood cancer survivors. New directions in research include novel risk-prediction strategies and the study of genetic predisposition.
  
  
  CONCLUSIONS
  Endocrine complications are observed in more than 50% of adult childhood cancer survivors. Some continue to develop decades following cancer treatment exposures. The present review provides a summary of the most recent outcomes research pertaining to growth, thyroid, gonadal-reproductive, bone and body composition with emphasis on new directions and challenges in each area.
authors.affiliation: aDepartment of Pediatric Medicine - Division of Endocrinology bDepartment of Epidemiology and Cancer Control cDepartment of Oncology-Division of Survivorship3, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Wassim
authors.initials: W
authors.lastname: Chemaitilly
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
mesh_terms: D000293:Adolescent; D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000473:pathology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D004703:Endocrine System / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000473:pathology*; D007006:Hypogonadism / Q000139:chemically induced / Q000473:pathology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D015995:Prevalence; D017741:Survivors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D019382:Human Growth Hormone