title: Impact of antimüllerian hormone assays on the outcomes of in vitro fertilization: a prospective controlled study.
abstract: OBJECTIVE
  To assess the value of routine antimüllerian hormone (AMH) assays in patients considered high risk for cancellation.
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  A private IVF center, Cairo, Egypt.
  
  
  METHODS
  In total 4,917 patients received counseling before starting IVF/intracytoplasmic sperm injection (ICSI). They were comprised of group A1 (n = 1,335), who were considered to be at risk for cancellation after ovarian stimulation, and group A2 (n = 3,582), who were considered low risk for cancellation. A control group, B (n = 4,639), included group B1 (n = 1,248) and group B2 (n = 3,391) based on the same criteria as groups A1 and A2.
  
  
  METHODS
  An AMH assessment was performed for group A1. All of the patients were stimulated using the long GnRH agonist protocol. Patients with low AMH levels received the flare-up protocol.
  
  
  METHODS
  The cancellation of IVF/ICSI cycles before or after stimulation, as well as the pregnancy rates (PR) in relation to AMH levels.
  
  
  RESULTS
  The group A1 patients (6.4%) did not start IVF due to low AMH, and some (6.6%) had their cycles canceled due to poor responses, compared with 2.6% in group A2 and 13.2% in group B1. The clinical PR was 42% in patients with normal AMH and 20% in patients with low AMH. The differences among these three groups were highly significant.
  
  
  CONCLUSIONS
  The AMH assays reduced the cancellations, cost, and stress experienced by couples.
authors.affiliation: Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; The Egyptian IVF Center, Cairo, Egypt. Electronic address: gharmd@gmail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Aboulghar
authors.affiliation: Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; The Egyptian IVF Center, Cairo, Egypt.
authors.forename: Walid
authors.initials: W
authors.lastname: Saber
authors.affiliation: The Egyptian IVF Center, Cairo, Egypt.
authors.forename: Yahia
authors.initials: Y
authors.lastname: Amin
authors.affiliation: Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt; The Egyptian IVF Center, Cairo, Egypt.
authors.forename: Mona M
authors.initials: MM
authors.lastname: Aboulghar
authors.affiliation: The Egyptian IVF Center, Cairo, Egypt; Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt.
authors.forename: Gamal
authors.initials: G
authors.lastname: Serour
authors.affiliation: The Egyptian IVF Center, Cairo, Egypt.
authors.forename: Ragaa
authors.initials: R
authors.lastname: Mansour
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends; D011446:Prospective Studies
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; IVF; cancellation rate; poor responder