title: CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH).
abstract: Mounting epidemiological evidence points to an association between metabolic syndrome and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH pathologies include hepatocellular ballooning, lobular inflammation, hepatocellular injury, apoptosis, and hepatic fibrosis. We will review the relationship between insulin resistance and inflammation in visceral obesity and NASH in an attempt to shed more light on the pathogenesis of these major metabolic diseases. Moreover, we will identify loss of the carcinoembryonic antigen-related cell adhesion molecule 1 as a unifying mechanism linking the immunological and metabolic abnormalities in NASH.
authors.affiliation: Center for Diabetes and Endocrine Research, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail stop 1009, Toledo, OH, 43614, USA, Sonia.Najjar@utoledo.edu.
authors.forename: Sonia M
authors.initials: SM
authors.lastname: Najjar
authors.forename: Lucia
authors.initials: L
authors.lastname: Russo
mesh_terms: D000818:Animals; D015703:Antigens, CD; D015815:Cell Adhesion Molecules / Q000172:deficiency*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007333:Insulin Resistance / Q000235:genetics; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000209:etiology*; D056128:Obesity, Abdominal / Q000209:etiology
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules