title: Increased level of resistin predicts development of atrial fibrillation.
abstract: BACKGROUND
  Resistin is a peptide hormone that is secreted from lipid cells and is linked to type-2 diabetes, obesity, and inflammation. Being an important adipocytokine, resistin was proven to play an important role in cardiovascular disease. We compared resistin levels in patients with and without atrial fibrillation (AF) to demonstrate the relationship between plasma resistin levels and AF.
  
  
  METHODS
  One hundred patients with AF and 58 control patients who were matched in terms of age, gender, and risk factors were included in the trial. Their clinical risk factors, biometric measurements, echocardiographic work up, biochemical parameters including resistin and high-sensitivity C-reactive protein (hs-CRP) levels were compared.
  
  
  RESULTS
  In patients with AF, plasma resistin levels (7.34±1.63ng/mL vs 6.67±1.14ng/mL; p=0.003) and hs-CRP levels (3.01±1.54mg/L vs 2.16±1.28mg/L; p=0.001) were higher than control group. In subgroup analysis, resistin levels were significantly higher in patients with paroxysmal (7.59±1.57ng/mL; p=0.032) and persistent AF (7.73±1.60ng/mL; p=0.006), but not in patients with permanent AF subgroups (6.86±1.61ng/mL; p=0.92) compared to controls. However, hs-CRP levels were significantly higher only in permanent AF patients compared to control group (3.26±1.46mg/L vs 2.16±1.28mg/L; p=0.02). In multivariate regression analysis using model adjusted for age, gender, body mas index, hypertension, diabetes mellitus, and creatinine levels, plasma resistin levels [odds ratio (OR): 1.30; 95% confidence interval (CI): 1.01-1.70; p=0.04] and hs-CRP levels (OR: 1.44; 95% CI: 1.12-1.86; p=0.004) were the only independent predictors of AF.
  
  
  CONCLUSIONS
  The elevated levels of plasma resistin were related to paroxysmal AF group and persistent AF group, but not to permanent AF group.
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Kazım Serhan
authors.initials: KS
authors.lastname: Özcan
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey. Electronic address: drbarisgungor@gmail.com.
authors.forename: Barış
authors.initials: B
authors.lastname: Güngör
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Altay
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Damirbek
authors.initials: D
authors.lastname: Osmonov
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ekmekçi
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Özpamuk
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Kemaloğlu
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Yıldırım
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: Gülşah
authors.initials: G
authors.lastname: Tayyareci
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, Turkey.
authors.forename: İzzet
authors.initials: İ
authors.lastname: Erdinler
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D052243:Resistin / Q000097:blood*
chemical_list: D015415:Biomarkers; D052243:Resistin; D002097:C-Reactive Protein
keywords: Adipocytokines; Atrial fibrillation; Inflammation; Resistin