title: Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry.
abstract: In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud sound stimulus. Two techniques were used to study the changes in blood flow, a Doppler optical microangiography (DOMAG) system; which can measure the blood flow within individual cochlear vessels, and a laser Doppler flowmetry (LDF) system; which averages the blood flow within a volume (a hemisphere of ~1.5 mm radius) of tissue. Both systems determined that the blood flow within the cochlea is reduced due to the LSE stimulation.
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, WA 98195, USA;
authors.forename: Roberto
authors.initials: R
authors.lastname: Reif
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Zhi
authors.forename: Suzan
authors.initials: S
authors.lastname: Dziennis
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Nuttall
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
keywords: Cochlear blood flow (CoBF); Doppler optical microangiography (DOMAG); hypoxia