title: Detection of intratumoral susceptibility signals using T2*-weighted gradient echo MRI in patients with clear cell renal cell carcinoma.
abstract: OBJECTIVE
  To retrospectively evaluate whether T2*-weighted imaging can be used to grade clear cell renal cell carcinomas (ccRCC) based on intratumoral susceptibility signals (ISSs).
  
  
  METHODS
  MR imaging from 37 patients with pathologically-proven ccRCCs was evaluated. ISSs on T2*WI were classified as linear or conglomerated linear structures (type I) and dot-like or patchy foci (type II). Two radiologists assessed the likelihood of the presence of ISS, dominant structure of ISS and ratio of ISS area to tumor area. Results were analyzed by nonparametric Mann-Whitney test.
  
  
  RESULTS
  ISSs were seen in all patients except for four patients with low-grade ccRCCs and two patients with high-grade ccRCCs. There was no significant difference of the likelihood of the presence of ISS between low- and high-grade ccRCCs. More type I ISSs and less type II ISSs were predictive of low-grade tumors, whereas more conspicuity type II ISSs correlated with higher occurrence of high-grade tumors (P<0.05). The ratio of ISS area to tumor area was also significantly higher for the high-grade group (1.27±0.79) than that for the low-grade group (0.81±0.40) (P<0.05).
  
  
  CONCLUSIONS
  ISSs on T2*-weighted gradient-echo MR images can help grade ccRCCs before operations.
authors.affiliation: Department of Radiology, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Yu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Qiu
authors.forename: Jinggang
authors.initials: J
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Pan
authors.forename: Shijun
authors.initials: S
authors.lastname: Xing
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012189:Retrospective Studies; D055815:Young Adult