title: The Relationship Between Vitamin E Plasma and BAL Concentrations, SOD Activity and Ventilatory Support Measures in Critically Ill Patients.
abstract: Vitamin E is a potent reactive oxygen metabolites (ROM) scavenger. It is a lipid-soluble vitamin and its main function is to protect polyunsaturated fatty acids against oxidative stress. Twenty-five mechanically ventilated Intensive Care Unit (ICU) adult patients participated in a prospective randomized clinical trial receiving either placebo (10 patients) or 3 IM doses (1000 IU each) of vitamin E (15 patients). We determined plasma and bronchoalveolar lavage (BAL) fluid concentrations of vitamin E and superoxide dismutase (SOD). Among these 25 patients, there were 14 men and 11 women, aged 63.16 ±15.48 years (mean ± SD; range = 33 to 87 years). Vitamin E supplementation resulted in significant differences in plasma and BAL vitamin E concentrations between the two groups (p-value = 0.01, 0.01), decrease in SOD activities (not differ significantly in plasma (p-value = 0.23)), but with significant differences in BAL (p-value = 0.016) and progressive reduction in Acute Physiology and Chronic Health Evaluation II (APACHE II) (p-value = 0.52) and Sequential Organ Failure Assessment (SOFA) (p-value = 0.008) score in vitamin E group. From the results of this study, it seems that supplementation of vitamin E as a potent antioxidant, along with other supportive measures, can be beneficial in decreasing SOD total activity, ROM production and risk of organ failure in critically ill patients.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shadi
authors.initials: S
authors.lastname: Ziaie
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Jamaati
authors.forename: Mannan
authors.initials: M
authors.lastname: Hajimahmoodi
authors.forename: Seyyed Mohammadreza
authors.initials: SM
authors.lastname: Hashemian
authors.forename: Fanak
authors.initials: F
authors.lastname: Fahimi
authors.forename: Behrooz
authors.initials: B
authors.lastname: Farzanegan
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Moghaddam
authors.forename: Golnar
authors.initials: G
authors.lastname: Radmand
authors.forename: Behzad
authors.initials: B
authors.lastname: Vahdani
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Nadji
authors.forename: Sarah
authors.initials: S
authors.lastname: Mousavi
authors.forename: Hadi
authors.initials: H
authors.lastname: Hamishehkar
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Mojtahedzadeh
keywords: Antioxidant; Mechanical ventilation; Oxidative stress; SOD; Vitamin E