title: The effect of obesity in adolescence on adult health status.
abstract: OBJECTIVE
  To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults.
  
  
  METHODS
  Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were ≥80% certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders.
  
  
  RESULTS
  Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42% of subjects were healthy weight, 29% overweight, 16% class 1 obese, and 13% class ≥2 obese. Compared with healthy weight at age 18, class ≥2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435% (P < .0001), severe walking limitation by 321% (P < .0001), abnormal kidney function by 302% (P < .0001), polycystic ovary syndrome by 74% (P = .03), asthma by 48% (P = .01), diabetes by 42% (P < .01), obstructive sleep apnea by 25% (P < .01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61% (P < .01).
  
  
  CONCLUSIONS
  Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery.
authors.affiliation: Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2023, Cincinnati, OH 45229-3039. thomas.inge@cchmc.org.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Inge
authors.forename: Wendy C
authors.initials: WC
authors.lastname: King
authors.forename: Todd M
authors.initials: TM
authors.lastname: Jenkins
authors.forename: Anita P
authors.initials: AP
authors.lastname: Courcoulas
authors.forename: Mark
authors.initials: M
authors.lastname: Mitsnefes
authors.forename: David R
authors.initials: DR
authors.lastname: Flum
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Wolfe
authors.forename: Alfons
authors.initials: A
authors.lastname: Pomp
authors.forename: Greg F
authors.initials: GF
authors.lastname: Dakin
authors.forename: Saurabh
authors.initials: S
authors.lastname: Khandelwal
authors.forename: Meg H
authors.initials: MH
authors.lastname: Zeller
authors.forename: Mary
authors.initials: M
authors.lastname: Horlick
authors.forename: John R
authors.initials: JR
authors.lastname: Pender
authors.forename: Jia-Yuh
authors.initials: JY
authors.lastname: Chen
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Daniels
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D050110:Bariatric Surgery; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000601:surgery; D063766:Pediatric Obesity / Q000453:epidemiology* / Q000601:surgery; D012044:Regression Analysis; D012307:Risk Factors; D057566:Self Report; D014481:United States / Q000453:epidemiology
keywords: bariatric; obesity; weight history