title: The carbohydrate-active enzymes database (CAZy) in 2013.
abstract: The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Functional and 3D structural information is added and curated on a regular basis based on the available literature. In addition to the use of the database by enzymologists seeking curated information on CAZymes, the dissemination of a stable nomenclature for these enzymes is probably a major contribution of CAZy. The past few years have seen the expansion of the CAZy classification scheme to new families, the development of subfamilies in several families and the power of CAZy for the analysis of genomes and metagenomes. This article outlines the changes that have occurred in CAZy during the past 5 years and presents our novel effort to display the resolution and the carbohydrate ligands in crystallographic complexes of CAZymes.
authors.affiliation: Centre National de la Recherche Scientifique, CNRS UMR 7257, 13288 Marseille, France and Aix-Marseille Université, AFMB, 163 Avenue de Luminy, 13288 Marseille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lombard
authors.forename: Hemalatha
authors.initials: H
authors.lastname: Golaconda Ramulu
authors.forename: Elodie
authors.initials: E
authors.lastname: Drula
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Coutinho
authors.forename: Bernard
authors.initials: B
authors.lastname: Henrissat
mesh_terms: D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D016678:Genome; D020407:Internet; D008024:Ligands; D011487:Protein Conformation; D020539:Sequence Analysis, Protein; D013379:Substrate Specificity
chemical_list: D002241:Carbohydrates; D004798:Enzymes; D008024:Ligands