title: Aberrant expression of CXCR4 significantly contributes to metastasis and predicts poor clinical outcome in breast cancer.
abstract: Triple negative breast cancer is known for its visceral metastasis. We have found that CXCR4 is overexpressed in triple negative breast cancer and is associated with visceral metastasis. We further investigated whether CXCR4 is a prognostic factor affecting survival following visceral metastasis in breast cancer patients. Our results indicate that increased CXCR4 expression among breast cancer patients with visceral metastasis was positively correlated with poor overall survival (P<0.001). Silencing of CXCR4 was associated with a decrease in the tumorigenic properties of MDA-MB-231 breast cancer cells, caused reversion of EMT and suppression of MMP-9, increased apoptosis, and caused a reduced incidence of tumor lung metastasis in mice. These results are indicative of CXCR4 having a predictive role in patients with visceral metastasis and indicate that shRNA knock down of CXCR4 might be a novel therapeutic strategy to prevent breast cancer metastasis when CXCR4 is overexpressed.
authors.forename: P
authors.initials: P
authors.lastname: Yang
authors.forename: S-X
authors.initials: SX
authors.lastname: Liang
authors.forename: W-H
authors.initials: WH
authors.lastname: Huang
authors.forename: H-W
authors.initials: HW
authors.lastname: Zhang
authors.forename: X-L
authors.initials: XL
authors.lastname: Li
authors.forename: L-H
authors.initials: LH
authors.lastname: Xie
authors.forename: C-W
authors.initials: CW
authors.lastname: Du
authors.affiliation: (C.-W. Du) Department of Breast Medical Oncology, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515031, P.R. China. dusumc@aliyun.com.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004195:Disease Models, Animal; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015870:Gene Expression; D020868:Gene Silencing; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D051379:Mice; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D019718:Receptors, CXCR4 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D047368:Tumor Burden / Q000235:genetics; D014410:Tumor Stem Cell Assay; D023041:Xenograft Model Antitumor Assays
chemical_list: D019718:Receptors, CXCR4