title: Effect of Pimpinellatirupatiensison Oxidative Enzymes in STZ-induced Diabetic Rat Kidney.
abstract: The present study was aimed to evaluate the therapeutic potential of Pimpinellatirupatiensis(Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitrate dehydrogenase (ICDH). Lactate dehydrogenase (LDH) activity was significantly (p < 0.01) increased in diabetic rats. The daily oral treatment of Pimpinellatirupatiensisethyl alcohol extract (750 mg/kg body weight/day) to diabetic rats for 30 days reversed the above changes in a significant (p < 0.01) manner. From our observations, we conclude that administration of Pt altered the activities of oxidative enzymes, thereby suggesting its role in mitochondrial energy production. The obtained results were compared with Glibenclamide, a standard anti diabetic drug. Thus, the modulatory effects of Pt on altering these enzymes activities afford a promise for widespread use for treatment of diabetes in the future.
authors.affiliation: Division of Molecular Biology and Exercise Physiology, Department of Zoology, Sri Venkateswara University, Tirupati-517502, A.P. India. ; Department of Biotechnology School of Herbal Studies and Naturo Sciences Dravidian University Kuppam.
authors.forename: Saddala
authors.initials: S
authors.lastname: Rajeswarareddy
authors.forename: Thopireddy
authors.initials: T
authors.lastname: Lavany
authors.forename: Ganapathi
authors.initials: G
authors.lastname: Narasimhulu
authors.forename: Kesireddy
authors.initials: K
authors.lastname: Sathyavelureddy
keywords: Diabetes; Mitochondrial enzymes; Oxidative stress; Pimpinellatirupatiensis