title: Surfactant-assisted size control of hydroxyapatite nanorods for bone tissue engineering.
abstract: This study presents the physicochemical characterization of the pluronic surfactant-assisted size control of hydroxyapatite (HAp) nanorods for bone tissue engineering (BTE). Rod-shaped HAp nanoparticles were synthesized via a simple route by hydrothermal treatment and with the assistance of the triblock co-polymer PEO20-PPO70-PEO20 (P123). The films of poly (d, l) lactic acid (PDLLA) were prepared as a substrate to spread synthesized HAp nanorods. Powder X-ray diffraction (XRD), field electron scanning microscopy, Fourier transform infrared spectroscopy, nitrogen adsorption isotherms, and energy-dispersive X-ray spectroscopy were used to characterize the structure and composition of the HAp samples. Results showed that regular rod-shaped HAp nanoparticles (with a mean length of 120 nm and a mean width of 28 nm) were successfully produced. Moreover, synthesized HAp nanorods revealed the rapid formation of bone-like apatite with a distinctive morphology, similar to flower-like apatite; the formation was observed as early as 7 days after incubation in stimulated body fluids. This study is a positive addition to the ongoing research on the preparation of HAp nanostructures toward the development of biocompatible composite scaffolds for BTE applications.
authors.affiliation: School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Viet Nam. Electronic address: nga.nguyenkim@hust.edu.vn.
authors.forename: Nguyen Kim
authors.initials: NK
authors.lastname: Nga
authors.affiliation: School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Viet Nam.
authors.forename: Luu Truong
authors.initials: LT
authors.lastname: Giang
authors.affiliation: National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi, Viet Nam.
authors.forename: Tran Quang
authors.initials: TQ
authors.lastname: Huy
authors.affiliation: Research Center for Environmental Technology and Sustainable Development, Hanoi University of Science, 334 Nguyen Trai Street, Hanoi, Viet Nam.
authors.forename: Pham Hung
authors.initials: PH
authors.lastname: Viet
authors.affiliation: Department of Industrial Engineering and BIOtech Research Centre, University of Trento, Via Mesiano, 77, I-38123 Trento, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Migliaresi
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001861:Bone Regeneration; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D013501:Surface-Active Agents; D017886:Durapatite
keywords: Bioactivity; Bone tissue engineering; Hydroxyapatite nanorods; Pluronic; SBF