title: A first generation compact microbeam radiation therapy system based on carbon nanotube X-ray technology.
abstract: We have developed a compact microbeam radiation therapy device using carbon nanotube cathodes to create a linear array of narrow focal line segments on a tungsten anode and a custom collimator assembly to select a slice of the resulting wedge-shaped radiation pattern. Effective focal line width was measured to be 131μm, resulting in a microbeam width of ∼300μm. The instantaneous dose rate was projected to be 2 Gy/s at full-power. Peak to valley dose ratio was measured to be >17 when a 1.4 mm microbeam separation was employed. Finally, multiple microbeams were delivered to a mouse with beam paths verified through histology.
authors.affiliation: Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hadsell
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Laganis
authors.forename: F
authors.initials: F
authors.lastname: Sprenger
authors.forename: J
authors.initials: J
authors.lastname: Shan
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Burk
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.forename: S
authors.initials: S
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: O
authors.initials: O
authors.lastname: Zhou