title: Chemokine-enhanced DNA vaccination in cancer immunotherapy.
abstract: We have demonstrated that priming of intratumoral and intradermal vaccination sites with chemokines enhances cytotoxic immune response against established neoplasms. Additional insights into the molecular mechanisms that underlie these findings and the optimization of such an approach may lead to the development of cost-effective and generic immunotherapeutic regimens against cancer.
authors.affiliation: Department of Dermatology and Cutaneous Biology; Jefferson Medical College; Thomas Jefferson University; Philadelphia, PA USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Igoucheva
authors.forename: Rebecca
authors.initials: R
authors.lastname: Jonas
authors.forename: Vitali
authors.initials: V
authors.lastname: Alexeev
keywords: DNA vaccine; chemokines; intradermal vaccination; intratumoral vaccination; leukocyte recruitment; therapeutic vaccine