title: [Effects of acupuncture of "Zhongchong" (PC 9) and "Yongquan" (KI 1) on P300 of event-related potentials in rats with vascular dementia].
abstract: OBJECTIVE
  To observe the effect of electroacupuncture (EA) stimulation of "Zhongchong" (PC 9) and "Yongquan" (KI 1) on P 300 of event-related potentials (ERPs) in rats with vascular dementia.
  
  
  METHODS
  A total of 48 Wistar rats were randomly divided into sham group (n = 12), model group (n = 12), EA group (n = 12) and medication group (n = 12). Vascular dementia model was established by occlusion of the bilateral vertebral arteries and cervical arteries. EA (1-2 mA, 2 Hz/20 Hz) was applied to bilateral "Zhongchong" (PC 9) and "Yongquan" (KI 1) for 15 min, once daily for 28 days. Rats of the medication group were treated by intragastric perfusion of Nimodipine (12 mg/kg), twice daily for 28 days. The rats' learning-memory ability was detected by step-down passive and active avoidance tests, and P 300 of ERPs detected by Neuroscan Nuamps system.
  
  
  RESULTS
  Compared with the sham group, the reaction time and error times of learning performance and error times of memory performance as well as P 300 latency in the model group were significantly increased (P < 0.01), and the latency of memory performance and the amplitude of P 300 were markedly decreased in the model group (P < 0.01). While in comparison with the model group, the reaction time and error times of learning performance, and the error times of memory performance as well as P300 latencies were obviously decreased in both EA and medication groups (P < 0.01), and the latencies of memory performance and P300 amplitudes were evidently increased in the EA and medication groups (P < 0.01). No significant differences were found between the EA and medication groups in these 6 indexes (P > 0.05).
  
  
  CONCLUSIONS
  EA of PC 9 and KI 1 can significantly improve the ability of learning and memory and the latency and amplitude of P 300 in rats with vascular dementia.
authors.affiliation: The 2nd Affiliated Hospital, Anhui College of Chinese Medicine, Hefei 230038, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Rong-Lin
authors.initials: RL
authors.lastname: Cai
authors.forename: Sheng-Bing
authors.initials: SB
authors.lastname: Wu
authors.forename: Liang
authors.initials: L
authors.lastname: Zhai
authors.forename: Kang
authors.initials: K
authors.lastname: Gao
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000818:Animals; D015140:Dementia, Vascular / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D018913:Event-Related Potentials, P300; D006801:Humans; D007858:Learning; D008297:Male; D008568:Memory; D051381:Rats; D017208:Rats, Wistar