title: Purification, characterization and comparative studies of spray-dried bacterial cellulose microparticles.
abstract: Bacterial cellulose (BC) is a biopolymer with significant potential for the development of novel materials. This work aimed to prepare and characterize BC powders from nata de coco, and assess the possible enhancement of the powder properties by spray drying. Therefore, BC powders prepared by acid treatment and mechanical processing were spray-dried, and characterized according to their morphology, flowability, thermal stability, water retention capacity, and compared with commercial microcrystalline cellulose (MCC). The powders redispersibility and suspensions rheology were also evaluated. SEM showed that spray-dried BC microparticles exhibited semispherical shape and had flow rate of 4.23 g s(-1) compared with 0.52 g s(-1) for MCC. Particle size analysis demonstrated that spray-dried BC microparticles could be redispersed. TGA showed that BC samples had higher thermal stability than MCC. Water retention capacities of BC samples were greater than MCC. These findings provide new insight on the potential applications of spray-dried BC as a promising pharmaceutical excipient.
authors.affiliation: Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia. Electronic address: mciamin@pharmacy.ukm.my.
authors.forename: Mohd Cairul Iqbal Mohd
authors.initials: MC
authors.lastname: Amin
authors.forename: Abadi Gumah
authors.initials: AG
authors.lastname: Abadi
authors.forename: Haliza
authors.initials: H
authors.lastname: Katas
mesh_terms: D002482:Cellulose / Q000737:chemistry* / Q000648:ultrastructure; D003890:Desiccation; D005079:Excipients; D006358:Hot Temperature; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000648:ultrastructure; D011208:Powders; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013535:Suspensions; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D005079:Excipients; D011135:Polysaccharides, Bacterial; D011208:Powders; D013535:Suspensions; D014867:Water; D002482:Cellulose
keywords: Bacterial cellulose; Flowability; Powder; Spray drying