title: Preoperative colonic lesion localization with charcoal nanoparticle tattooing for laparoscopic colorectal surgery.
abstract: The efficiency and safety of charcoal nanoparticle tattooing in localizing unpalpable colonic small lesions for later laparoscopy is described. Twenty six patients were enrolled for this prospective study. Tumor sites were localized with charcoal nanoparticles during colonoscopy for later laparoscopic colorectal operations. In all patients, the entire colon was examined preoperatively by colonoscopy and 0.5 ml (5 mg) of charcoal nanoparticle was injected submucosally near lesions or polypectomy sites. During laparoscopic colorectal operations for these biopsy-proven tumors, tumors were easily identified. The mean resection margin was 3.13 +/- 2.01 cm. The mean length of resected intestinal segment was 12.69 +/- 4.39 cm. No tumor was found at the resection line as indicated by postoperative pathological examination. Most importantly, no wrong segment was resected. Thus we show that easy identification of tumor can be achieved by preoperative tattooing with charcoal nanoparticles. Further studies regarding the long-term tattooing of tumor with charcoal nanoparticles are warranted.
authors.affiliation: Department of Digestive Diseases, Fuzhou General Hospital, Xiamen University, Fuzhou 350025, China. flyfishwang@hotmail.com
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Dazhou
authors.initials: D
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Nan
authors.initials: N
authors.lastname: Lin
authors.forename: Weijin
authors.initials: W
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Ren
authors.initials: R
authors.lastname: Lv
authors.forename: Lianming
authors.initials: L
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D002606:Charcoal; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles; D057234:Preoperative Period; D013653:Tattooing / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002606:Charcoal