title: Improved outcomes using brain SPECT-guided treatment versus treatment-as-usual in community psychiatric outpatients: a retrospective case-control study.
abstract: Brain single-photon emission computed tomography (SPECT) scans indirectly show functional activity via measurement of regional cerebral blood flow. Thirty patients at a community-based psychiatric clinic underwent brain SPECT scans. Changes in scoring of before-treatment and after-treatment scans correlated well with changes in patient Global Assessment of Functioning (GAF) scores before treatment and after treatment. Patients were retrospectively matched with controls with similar diagnoses and pretreatment GAF scores, and those who underwent SPECT-guided treatment improved significantly more than the control patients.
authors.forename: John F
authors.initials: JF
authors.lastname: Thornton
authors.forename: Howard
authors.initials: H
authors.lastname: Schneider
authors.forename: Mary K
authors.initials: MK
authors.lastname: McLean
authors.forename: Muriel J
authors.initials: MJ
authors.lastname: van Lierop
authors.forename: Robert
authors.initials: R
authors.lastname: Tarzwell
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D003553:Cystine / Q000031:analogs & derivatives; D005260:Female; D006778:Hospitals, Psychiatric; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D001523:Mental Disorders / Q000000981:diagnostic imaging* / Q000628:therapy*; D008875:Middle Aged; D010045:Outpatients; D011569:Psychiatric Status Rating Scales; D012111:Residence Characteristics; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome
chemical_list: C541351:ethyl cysteinate dimer; D003553:Cystine