title: Mammalian cell cultures for biologics manufacturing.
abstract: Biopharmaceuticals represent a growing sector of the pharmaceutical industry, and are used for a wide range of indications, including oncology and rheumatology. Cultured mammalian cells have become the predominant expression system for their production, partly due to their ability to complete the posttranslational modifications required for drug safety and efficacy. Over the past decade, the productivity of mammalian cell culture production processes has growth dramatically through improvements in both volumetric and specific productivities. This article presents an overview of the biologics market, including analysis of sales and approvals; as well as a review of industrial production cell lines and cell culture operations.
authors.affiliation: Upstream Development, Alexion Pharmaceuticals, Cheshire, CT, 06410, USA, Kantardjieffa@alxn.com.
authors.forename: Anne
authors.initials: A
authors.lastname: Kantardjieff
authors.forename: Weichang
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001688:Biological Products / Q000191:economics* / Q000600:supply & distribution / Q000627:therapeutic use*; D018929:Cell Culture Techniques / Q000191:economics* / Q000706:statistics & numerical data; D017277:Drug Approval / Q000191:economics* / Q000706:statistics & numerical data; D004345:Drug Industry / Q000191:economics* / Q000706:statistics & numerical data; D006801:Humans; D038622:Internationality; D008322:Mammals; D040541:Marketing / Q000191:economics* / Q000706:statistics & numerical data
chemical_list: D001688:Biological Products