title: Clinical features of Behcet's disease in patients without oral aphthosis.
abstract: OBJECTIVE
  In current study we evaluated clinical features of Behcet's Disease (BD) in patients without oral aphthosis (NOA cases).
  
  
  METHODS
  In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer's exact test.
  
  
  RESULTS
  Among 6,821 BD patients, 175 patients (2.56%) were NOA cases. Male/Female ratio was less in NOA cases (p-value: 0.078). Mean age of disease onset was significantly higher in NOA cases (p-value: 0.001). Among NOA cases, the first manifestations comprised uveitis (70.3%), joint involvement (8.0%), retinal vasculitis (6.9%), and genital aphthosis (4.0%). During the course of disease, the prevalence of ocular lesions and positive pathergy test were significantly higher in NOA cases. Conversely genital aphthosis (OR: 0.048), mucocutaneous (OR: 0.470), joint involvement (OR: 0.478), and positive family history for BD (OR:0.138) were significantly less frequent in NOA cases. NOA cases fulfilled different criteria including International Criteria for BD (ICBD), Japan Revised, Iran, Dilsen, and Classification Tree.
  
  
  CONCLUSIONS
  These results addressed the distinct clinical features in NOA subset of BD Including more prevalent eye involvement and positive pathergy.
authors.affiliation: Rheumatolology Research Center (RRC), Shariati Hospital, Tehran University of Medical Sciences, (TUMS) , Kargar Avenue, Tehran , Iran.
authors.forename: Seyedeh Tahereh
authors.initials: ST
authors.lastname: Faezi
authors.forename: Pedram
authors.initials: P
authors.lastname: Paragomi
authors.forename: Farhad
authors.initials: F
authors.lastname: Shahram
authors.forename: Hormoz
authors.initials: H
authors.lastname: Shams
authors.forename: Cheida
authors.initials: C
authors.lastname: Shams-Davatchi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ghodsi
authors.forename: Abdolhadi
authors.initials: A
authors.lastname: Nadji
authors.forename: Maassoumeh
authors.initials: M
authors.lastname: Akhlaghi
authors.forename: Fereydoun
authors.initials: F
authors.lastname: Davatchi
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063189:Symptom Assessment; D055815:Young Adult
keywords: Behcet's disease; Dermatology; Internal medicine; Ophthalmology; Oral aphthosis