title: Disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under azathioprine and steroids: First case report and literature review.
abstract: Immunosuppressive treatments used in the management of Inflammatory Bowel Disease, namely steroids, thiopurines and anti-TNF drugs, raise the risk of acquiring opportunistic infections. However, most of these infections are mild and self-limited, not requiring specific therapy or suspension of the immunosuppressors. We report a case of disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under steroids and azathioprine.
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal; Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Santos-Antunes
authors.affiliation: Department of Infectious Diseases, Faculty of Medicine, University of Porto, Portugal.
authors.forename: Cândida
authors.initials: C
authors.lastname: Abreu
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal; Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Portugal; Institute for Molecular and Cell Biology, Porto, Portugal. Electronic address: fm@med.up.pt.
authors.forename: Fernando
authors.initials: F
authors.lastname: Magro
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal.
authors.forename: Rosa
authors.initials: R
authors.lastname: Coelho
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal.
authors.forename: Filipe
authors.initials: F
authors.lastname: Vilas-Boas
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Andrade
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Lopes
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Macedo
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006561:Herpes Simplex / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine
keywords: Crohn's disease; Herpes Simplex Virus; Immunosuppression