title: Shape-memory starch for resorbable biomedical devices.
abstract: Shape-memory resorbable materials were obtained by extrusion-cooking of potato starch with 20% glycerol under usual conditions. They presented an efficient shape-memory with a high recovery ratio (Rr>90%). Their recovery could be triggered at 37°C in water. After water immersion at 37°C, the modulus decreased from 1GPa to 2.4MPa and remained almost constant over 21 days. Gamma-ray sterilization did not have a dramatic impact on their mechanical properties, despite a large decrease of molecular mass analyzed by asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering (AFFFF-MALLS). Samples implanted in a rat model exhibited normal tissue integration with a low inflammatory response. Thus, as previously investigated in the case of shape-memory synthetic polymers, natural starch, without chemical grafting, can now be considered for manufacturing innovative biodegradable devices for less-invasive surgery.
authors.affiliation: INRA, UR1268, Unité Biopolymères Interactions et Assemblages, rue de la géraudière, 44300 Nantes, France. Electronic address: anne.beilvert@nantes.inra.fr.
authors.forename: A
authors.initials: A
authors.lastname: Beilvert
authors.forename: F
authors.initials: F
authors.lastname: Chaubet
authors.forename: L
authors.initials: L
authors.lastname: Chaunier
authors.forename: S
authors.initials: S
authors.lastname: Guilois
authors.forename: G
authors.initials: G
authors.lastname: Pavon-Djavid
authors.forename: D
authors.initials: D
authors.lastname: Letourneur
authors.forename: A
authors.initials: A
authors.lastname: Meddahi-Pellé
authors.forename: D
authors.initials: D
authors.lastname: Lourdin
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D058107:Abdominal Wound Closure Techniques; D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D055119:Elastic Modulus; D005720:Gamma Rays; D005990:Glycerol / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011198:Solanum tuberosum / Q000737:chemistry; D013213:Starch / Q000737:chemistry* / Q000378:metabolism; D013242:Sterilization; D013314:Stress, Mechanical; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D013213:Starch; D005990:Glycerol
keywords: Biomaterial; DMA; Extrusion; In vivo implantation; RH; SMP; Shape-memory; Starch; T(Trans); Tg; dynamic mechanical analysis; glass transition temperature; relative humidity; shape-memory polymers; transition temperature; wb; wet basis