title: Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates.
abstract: Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
authors.affiliation: Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Faccone
authors.affiliation: Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.
authors.forename: Omar
authors.initials: O
authors.lastname: Veliz
authors.affiliation: Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
authors.affiliation: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
authors.forename: Martin
authors.initials: M
authors.lastname: Noguera
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina.
authors.forename: Melina
authors.initials: M
authors.lastname: Martínez
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
authors.forename: Cristian
authors.initials: C
authors.lastname: Payes
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina.
authors.forename: Liliana
authors.initials: L
authors.lastname: Semorile
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: pcmaffia@hotmail.com.
authors.forename: Paulo Cesar
authors.initials: PC
authors.lastname: Maffía
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D002942:Circular Dichroism; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides
keywords: Antimicrobial; Cationic; Peptides; Resistance