title: [Vitamin D deficiency in patients with common variable immunodeficiency, with autoimmune diseases and bronchiectasis].
abstract: BACKGROUND
  Vitamin D regulates cellular activity, also it has effects on: innate and adaptive immunity, antimicrobial, anti-inflammatory and immunomodulatory functions. It has been suggested a possible association between vitamin D deficiency and increased risk and length of respiratory infections in patients with common variable immunodeficiency (CVID).
  
  
  METHODS
  We conducted a descriptive study in patients with CVID. Vitamin D serum levels were measured in all patients. The results were analyzed using descriptive statistics by calculating measures of dispersion and central tendency.
  
  
  RESULTS
  We studied 20 patients, 13 women and 7 males, with an age average of 37 ± 13.43 years. The mean concentration of vitamin D in patients was 15.43 ng/mL ± 7.23. Thirty percent of all patients had severe Vitamin D deficiency, 45% had mild to moderate deficiency and 25% had insufficiency. Autoimmune diseases were associated in 35% of CVID patients, 42.8% of them had severe vitamin D deficiency. In patients with bronchiectasis, 85% were found with vitamin D deficiency, and it was severe in 35.2%. 41% of patients with bronchiectasis were classified as severe on the Bhalla score of severity, 57% of these patients had severe deficiency and 14.2% mild-moderate deficiency.
  
  
  CONCLUSIONS
  : We found deficiency of vitamin D in patients with CVID patients. Most of patients with CVID and bronchiectasis were detected with mild to severe vitamin D deficiency. Almost the half of patients with autoimmune diseases associated to CVID showed deficiency of vitamin D. We recommend to investigate the association of vitamin D deficiency on patients with immunodeficiencies.
authors.affiliation: Servicio de Alergia e Inmunología Clínica. Hospital de Especialidades Dr. Bernardo Sepúlveda, CMN Siglo XXI, IMSS, México, D.F. adelaamaya@hotmail.com.
authors.forename: Adela Sisy
authors.initials: AS
authors.lastname: Amaya-Mejía
authors.forename: Patricia María
authors.initials: PM
authors.lastname: O'Farrill-Romanillos
authors.forename: Lucy Vania
authors.initials: LV
authors.lastname: Galindo-Pacheco
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Vargas-Ortega
authors.forename: Victoria
authors.initials: V
authors.lastname: Mendoza-Zubieta
authors.forename: Leonel Gerardo
authors.initials: LG
authors.lastname: Del Rivero-Hernández
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications*; D001987:Bronchiectasis / Q000209:etiology*; D017074:Common Variable Immunodeficiency / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D014808:Vitamin D Deficiency / Q000150:complications*