title: Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination.
abstract: Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccination-induced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion.
authors.affiliation: Masonic Cancer Center; University of Minnesota; Minneapolis; MN USA ; Brain Tumor Program; University of Minnesota; Minneapolis, MN USA ; Department of Pediatrics; University of Minnesota; Minneapolis, MN USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Litterman
authors.forename: Arkadiusz Z
authors.initials: AZ
authors.lastname: Dudek
authors.forename: David A
authors.initials: DA
authors.lastname: Largaespada
keywords: alkylating chemotherapy; cancer vaccines; chemoimmunotherapy; neo-antigens; regulatory T cells