title: Acute cytomegalovirus hepatitis in an immunocompetent host.
abstract: A 52-year-old woman presented with a 1-week history of recurrent fevers and joint pains accompanied by abdominal and low back discomfort. She has a history of hypoparathyroidism and is on calcium supplements. Physical examination revealed fever and tachycardia. The rest of the examination was normal. Laboratory tests showed newly increased transaminase activity. Serum bilirubin and prothrombin time were normal. She was admitted for evaluation of acute hepatitis. Serology for hepatitis A, B, C and HIV were negative. Her serum acetaminophen and alcohol were undetected. Abdominal imaging was normal. Cultures were sterile. Additional tests for uncommon viral hepatitis included herpes simplex virus, cytomegalovirus and Epstein-Barr virus. Liver biopsy revealed non-specific inflammation. Subsequently, cytomegalovirus serology showed an IgM positive and negative IgG titre. Cytomegalovirus DNA qualitative PCR was also positive. No antiviral medication was given. She continued to have intermittent daily fever but reported no associated symptoms. She was discharged 9 days after admission in stable condition per her request with the advice to follow-up in the clinic in 1 week. Her serum hepatic profile returned to normal and she reported no more episodes of fever. Repeated titres of cytomegalovirus serology showed seroconversion.
authors.affiliation: Department of Medicine, Metropolitan Hospital Center, New York and New York Medical College, Valhalla, New York, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Sy
authors.forename: Olabimpe
authors.initials: O
authors.lastname: Omobomi
authors.forename: Theodore
authors.initials: T
authors.lastname: Lenox
authors.forename: Nora V
authors.initials: NV
authors.lastname: Bergasa
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006505:Hepatitis / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase