title: SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis.
abstract: BACKGROUND
  Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.
  
  
  METHODS
  We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.
  
  
  RESULTS
  The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p<0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p<0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p<0.05).
  
  
  CONCLUSIONS
  The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.
  
  
  
  Expression de SPARC et de Vav3 dans le méningiome : facteurs reliés au pronostic.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
authors.forename: Yuejia
authors.initials: Y
authors.lastname: Song
authors.forename: Nan
authors.initials: N
authors.lastname: Liu
authors.forename: Chengjun
authors.initials: C
authors.lastname: Lin
authors.forename: Shiguang
authors.initials: S
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Fang
authors.forename: Jiping
authors.initials: J
authors.lastname: Qi
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms; D008579:Meningioma; D009364:Neoplasm Recurrence, Local; D011379:Prognosis