title: Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives.
abstract: A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplatealamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC90, 7.57 and 2.96 μg/mL, respectively.
authors.affiliation: Department of Medicinal Chemistry, Facalty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Almasirad
authors.forename: Somayeh
authors.initials: S
authors.lastname: Samiee-Sadr
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
keywords: 5-Nitrofuran; 5-Nitrothiophen; Antimycobacterial activity; Hydrazones; Mycobacterium tuberculosis