title: [Peroxisome proliferator-activated receptors-gamma and hypertension: lessons of the history of researches].
abstract: The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-gamma) gene removal, and also those on the role of PPAR-alpha and -gamma in the function of the vascular endothelium, sympathetic autonomic nervous system, and renal sodium reabsorption. It is concluded that the tonic activity of PPAR is a universal protective mechanism counteracting the development of hypertension.
authors.forename: M S
authors.initials: MS
authors.lastname: Rasin
mesh_terms: D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: D047493:PPAR alpha; D047495:PPAR gamma; D045162:Thiazolidinediones