title: Serosurveillance of foot-and-mouth disease in sheep and goat population of India.
abstract: Serological investigation to detect foot-and-mouth disease (FMD) virus circulation in the domestic small ruminant population of India was conducted. A total of 4407 and 4035 serum samples from sheep and goats, respectively were collected at random covering majority of the states across the country during 2010-2012. These samples were analyzed for antibodies against the non-structural proteins (NSP) of FMD virus in an indirect 3AB NSP ELISA and against the structural proteins (SP) in a liquid phase blocking (LPB) ELISA. A total of 20.35% sheep and 13.60% goats were found to be positive for 3AB NSP antibodies providing a serological evidence of extensive viral activity. In LPB ELISA, only 4.54% sheep and 6.27% goats were found to have protective antibody (log10 titre of ≥1.8) against all three serotype strains in the vaccine, which correlates with "no or sparse vaccination" scenario in these species in the country. Hence, to check silent amplification and dissemination of virus in a mixed farming set up, small ruminants may be brought under the ambit of routine vaccination and surveillance programmes.
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India.
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Rout
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India.
authors.forename: Manas R
authors.initials: MR
authors.lastname: Senapati
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India. Electronic address: jajati1@gmail.com.
authors.forename: Jajati K
authors.initials: JK
authors.lastname: Mohapatra
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India.
authors.forename: Bana B
authors.initials: BB
authors.lastname: Dash
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India.
authors.forename: Aniket
authors.initials: A
authors.lastname: Sanyal
authors.affiliation: Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar 263138, Nainital, Uttarakhand, India.
authors.forename: Bramhadev
authors.initials: B
authors.lastname: Pattnaik
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D015511:Goat Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D006041:Goats; D007194:India / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral
keywords: Foot-and-mouth disease; Goat; India; Serosurveillance; Sheep