title: Epigenetics, vitamin supplements and cellular reprogramming.
abstract: The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, the Walter and Eliza Hall Institute of Medical Research, and the Florey Neuroscience and Mental Health Institute, Melbourne, Victoria, Australia.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Pera
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D065150:Cellular Reprogramming / Q000187:drug effects*; D004268:DNA-Binding Proteins / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C540839:TET1 protein, mouse; D001205:Ascorbic Acid