title: Different evolutionary patterns of hypoxia-inducible factor α (HIF-α) isoforms in the basal branches of Actinopterygii and Sarcopterygii.
abstract: Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in different lineages. Only the HIF-1α and HIF-2α in African lungfish and amphibians were found under positive selection. HIF-1α and -2α were less functionally divergent in basal ray-finned fish than in teleosts, and showed conserved but different transcriptional activity towards specific target genes.
authors.affiliation: Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7# Donghu South Road, Wuhan, Hubei 430072, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chi
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Gan
authors.forename: Wuhan
authors.initials: W
authors.lastname: Xiao
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.forename: Shunping
authors.initials: S
authors.lastname: He
keywords: C-ODD, C-terminal oxygen dependent degradation domain; C-TAD, C-terminal trans-activation domain; Functional divergence; HIF-α; N-ODD, N-terminal oxygen dependent degradation domain; N-TAD, N-terminal trans-activation domain; Osteichthyes; Positive selection