title: [Involvement of matrix metalloproteinases in acute coronary syndrome (ACS)].
abstract: Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix (ECM) proteins and regulate both their accumulation and composition. The MMP are involved in the atherosclerotic process since they contribute to the formation of the plaque and its subsequent rupture. This last step triggers the myocardial ischemia that will be clinically reflected as an acute coronary syndrome (ACS). Thus, MMP activity is a key to whether ACS develops or not. With an elevated transcription rate of the genes that codify these proteinases comes a higher enzymatic activity. This explains that if a polymorphism in the mentioned genes modifies transcription, there could be a predisposition to developing ACS. Several studies reveal that certain genetic variations in MMP-1, -2, -3, -7, -8, -9, -12, and -14 have an important role either as risk factors or as protective factors for the expression of ACS.
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F. josemanuel_rodriguezperez@yahoo.com.mx.
authors.forename: Nonanzit
authors.initials: N
authors.lastname: Pérez-Hernández
authors.forename: Cyntia
authors.initials: C
authors.lastname: Ibanes-Gutiérrez
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.forename: Irma Eloísa
authors.initials: IE
authors.lastname: Monroy-Muñoz
authors.forename: Benjamín
authors.initials: B
authors.lastname: Valente-Acosta
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.forename: Roxana
authors.initials: R
authors.lastname: Barrera-Ramírez
authors.forename: Teresa
authors.initials: T
authors.lastname: Juárez-Cedillo
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez Pérez
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology* / Q000235:genetics; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology*; D011110:Polymorphism, Genetic
chemical_list: D020782:Matrix Metalloproteinases