title: Nutritional components regulate the gut immune system and its association with intestinal immune disease development.
abstract: The gut is equipped with a unique immune system for maintaining immunological homeostasis, and its functional immune disruption can result in the development of immune diseases such as food allergy and intestinal inflammation. Accumulating evidence has demonstrated that nutritional components play an important role in the regulation of gut immune responses and also in the development of intestinal immune diseases. In this review, we focus on the immunological functions of lipids, vitamins, and nucleotides in the regulation of the intestinal immune system and as potential targets for the control of intestinal immune diseases.
authors.affiliation: Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan; Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka, Japan.
authors.forename: Aayam
authors.initials: A
authors.lastname: Lamichhane
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
authors.forename: Jun
authors.initials: J
authors.lastname: Kunisawa
mesh_terms: D005502:Food; D005512:Food Hypersensitivity / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000517:prevention & control; D008055:Lipids / Q000502:physiology*; D008246:Lysophospholipids / Q000502:physiology; D009711:Nucleotides / Q000502:physiology*; D009747:Nutritional Physiological Phenomena / Q000276:immunology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology; D014815:Vitamins / Q000502:physiology*
chemical_list: D008055:Lipids; D008246:Lysophospholipids; D009711:Nucleotides; D014815:Vitamins; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: allergy; intestinal immunity; lipid; nucleotide; vitamin