title: Affective state-dependent changes in the brain functional network in major depressive disorder.
abstract: In major depressive disorder (MDD), as a network-level disease, the pathophysiology would be displayed to a wide extent over the brain. Moreover, the network-wide changes could be dependent on the context of affective processing. In this study, we sought affective state-dependent changes of the brain functional network by applying a graph-theoretical approach to functional magnetic resonance imaging data acquired in 13 patients with MDD and 12 healthy controls who were exposed to video clips inducing the negative, neutral or positive affective state. For each affective condition, a group-wise brain functional network was constructed based on partial correlation of mean activity across subjects between brain areas. Network parameters, global and local efficiencies, were measured from the brain functional network. Compared with controls', patients' brain functional network shifted to the regular network in the topological architecture, showing decreased global efficiency and increased local efficiency, during negative and neutral affective processing. Further, the shift to the regular network in patients was most evident during negative affective processing. MDD is proposed to provoke widespread changes across the whole brain in an affective state-dependent manner, specifically in the negative affective state.
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Chang-hyun
authors.initials: CH
authors.lastname: Park
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Sheng-Min
authors.initials: SM
authors.lastname: Wang
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Hae-Kook
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Yong-Sil
authors.initials: YS
authors.lastname: Kweon
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Chung Tai
authors.initials: CT
authors.lastname: Lee
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Kim
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK, Department of Psychiatry and Department of Radiology, Uijeongbu St. Mary s Hospital, The Catholic University of Korea School of Medicine, Seoul, 137-701, Korea mindcure@catholic.ac.kr.
authors.forename: Kyoung-Uk
authors.initials: KU
authors.lastname: Lee
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011340:Problem Solving / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic
chemical_list: D010100:Oxygen
keywords: affective processing; fMRI; graph-theoretical analysis; major depressive disorder