title: MiR-200, a new star miRNA in human cancer.
abstract: MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms of miR-200 expression. The collected evidence supports that miR-200 is becoming a new star miRNA in study of human cancer.
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, United States.
authors.forename: Xiangling
authors.initials: X
authors.lastname: Feng
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, United States.
authors.forename: Zhengming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Biological Sciences, University of Southern Mississippi Gulf Coast, United States.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Fillmore
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, United States. Electronic address: xi@health.southalabama.edu.
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Xi
mesh_terms: D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*
chemical_list: C533896:MIRN200 microRNA, human; D035683:MicroRNAs
keywords: Cell cycle; EMT; MiR-200; MicroRNA; Stem cells; ZEB