title: The route less taken: pulmonary models of enteric Gram-negative infection.
abstract: Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram-negative bacteria are host-restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host-pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram-negative bacteria relative to naturally occurring lung pathogens.
authors.affiliation: Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Fisher
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Roy
authors.initials: R
authors.lastname: Curtiss
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004755:Enterobacteriaceae / Q000472:pathogenicity / Q000502:physiology*; D004756:Enterobacteriaceae Infections / Q000382:microbiology* / Q000473:pathology*; D051379:Mice; D018410:Pneumonia, Bacterial / Q000382:microbiology* / Q000473:pathology*
keywords: Gram-negative pathogens; respiratory/lung infection