title: Potentiation of enteral absorption of human interferon alpha and selective transfer into lymphatics in rats.
abstract: Enhancement of human leucocyte interferon (HuIFN-α) absorption from rat large intestine was studied with the aid of lipid, surfactant and lipid-surfactant mixed micelles. Neither the emulsified lipid (linoleic acid) nor the surfactant (HCO60, polyoxyethylated [60 moles] hydrogenated castor oil) alone were able to enhance the absorption of HuIFN-α. However, linoleic acid-HCO60 mixed micelles enhanced the absorption of HuIFN-α from the large intestine. Highly selective delivery of HuIFN-α into the lymphatics compared to the blood was also observed.
authors.affiliation: Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Naruse
authors.forename: S
authors.initials: S
authors.lastname: Muranishi