title: Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010).
abstract: BACKGROUND
  Patch testing is essential for identification of culprits causing allergic contact dermatitis.
  
  
  OBJECTIVE
  We sought to identify trends and allergen changes in our standard series during 2006 to 2010, compared with our previous report (2001-2005).
  
  
  METHODS
  We conducted a retrospective review of patch-test results.
  
  
  RESULTS
  A total of 3115 patients were tested with a mean of 73.0 allergens. Since our prior report, 8 allergens were added to the standard series; 14 were deleted. Significantly higher rates of allergic positive reaction were documented for carba mix, 3%, and Disperse Orange 3, 1%. Rates were lower for 10 allergens: neomycin sulfate, 20%; gold sodium thiosulfate, 0.5%; hexahydro-1,3,5-tris(2-hydroxyethyl)triazine, 1%; disperse blue 124, 1%; disperse blue 106, 1%; diazolidinyl urea, 1%; hexylresorcinol, 0.25%; diazolidinyl urea, 1% aqueous; 2-bromo-2-nitropropane-1,3-diol, 0.25%; and lidocaine, 5%. Many final patch-test readings for many allergens were categorized as mild reactions (erythema only). Overall allergenicity and irritancy rates declined significantly since our prior report. Results were generally comparable with those in a North American Contact Dermatitis Group report from 2005 to 2006.
  
  
  CONCLUSIONS
  This was a retrospective study; there is a lack of long-term follow-up.
  
  
  CONCLUSIONS
  Since our previous report, our standard series composition has changed, and overall rates of allergenicity and irritancy have decreased. Notably, many final patch-test readings showed mild reactions.
authors.affiliation: Mayo Medical School, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Ashley B
authors.initials: AB
authors.lastname: Wentworth
authors.affiliation: Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.
authors.forename: James A
authors.initials: JA
authors.lastname: Yiannias
authors.affiliation: Department of Dermatology, Mayo Clinic, Jacksonville, Florida.
authors.forename: James H
authors.initials: JH
authors.lastname: Keeling
authors.affiliation: Department of Dermatology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hall
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Camilleri
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Drage
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Rochelle R
authors.initials: RR
authors.lastname: Torgerson
authors.affiliation: Dermatology Solutions, Fort Myers, Florida.
authors.forename: Debra D
authors.initials: DD
authors.lastname: Fett
authors.affiliation: Dermatology, Watson Clinic Bella Vista Building, Lakeland, Florida.
authors.forename: Amy V
authors.initials: AV
authors.lastname: Prakash
authors.affiliation: Advanced Dermatology and Psoriasis Center, Lexington, Kentucky.
authors.forename: Leigh Ann
authors.initials: LA
authors.lastname: Scalf
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Eve M
authors.initials: EM
authors.lastname: Allen
authors.affiliation: Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.
authors.forename: Janis S
authors.initials: JS
authors.lastname: Johnson
authors.affiliation: Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Singh
authors.affiliation: Department of Dermatology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Diane L
authors.initials: DL
authors.lastname: Nordberg Linehan
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Killian
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address: davis.mark2@mayo.edu.
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Davis
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D000485:Allergens; D001391:Azo Compounds / Q000276:immunology; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D012971:Gold Sodium Thiosulfate / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D009595:Nitroparaffins / Q000276:immunology; D010328:Patch Tests / Q000592:standards* / Q000639:trends; D010880:Piperidines / Q000276:immunology; D011407:Propane / Q000031:analogs & derivatives / Q000276:immunology; D012015:Reference Standards; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D000485:Allergens; D001391:Azo Compounds; D009595:Nitroparaffins; D010880:Piperidines; C009871:diphenylpyraline; C069319:Disperse Blue 124; C041259:Disperse Orange 3; C049175:disperse blue 106; D012971:Gold Sodium Thiosulfate; C016617:2-nitropropane; D011407:Propane
keywords: ACD; MCCDG; Mayo Clinic Contact Dermatitis Group; NACDG; North American Contact Dermatitis Group; allergens/diagnostic use; allergic contact dermatitis; allergic contact/diagnosis; allergic contact/etiology; dermatitis; patch tests/methods; retrospective studies