title: Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.
abstract: We performed Monte Carlo simulation of the detachment of a polymorphonuclear (PMN) leukocyte immersed in a Newtonian fluid and adhered to a substrate by multiple catch-slip bonds. We found that at certain loading rates the interplay of multiple catch-slip bonds leads to a bimodal distribution of the bond rupture force. We also found that the low force peak in these bond rupture force distributions switches to a high force peak with a gradual increase in the loading rate. These trends in the bond rupture force distributions are characteristics of two-state systems. Consequently, though individual catch-slip bonds follow one-state two-pathway energy landscape, their interplay mimics a two-state two-pathway energy landscape.
authors.affiliation: University of Maryland Baltimore County, 21250, Baltimore, Maryland, USA, vkg@umbc.edu.
authors.forename: V K
authors.initials: VK
authors.lastname: Gupta
mesh_terms: D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D007101:Immersion; D019041:L-Selectin / Q000737:chemistry / Q000378:metabolism; D009010:Monte Carlo Method; D009504:Neutrophils / Q000166:cytology* / Q000378:metabolism; D014783:Viscosity
chemical_list: D019041:L-Selectin