title: CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population.
abstract: BACKGROUND
  Common psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.
  
  
  OBJECTIVE
  To investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population.
  
  
  METHODS
  We carried out a case-control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples.
  
  
  RESULTS
  We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
  
  
  CONCLUSIONS
  Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
authors.affiliation: Kuanjun He, PhD, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai and College of Life Science, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia; Zhiguo An, MS, Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi; Qingzhong Wang, PhD, Tao Li, PhD, Zhiqiang Li, PhD, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai; Jianhua Chen, PhD, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai and Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Wenjin Li, PhD, Ti Wang, PhD, Jue Ji, BM, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai and College of Life Science, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia; Guoyin Feng, BM, Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; He Lin, PhD, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai; Qizhong Yi, MD, PhD, Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi; Yongyong Shi, PhD, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, Shanghai Changning Mental Health Center, Shanghai and Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic 
authors.forename: Kuanjun
authors.initials: K
authors.lastname: He
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: An
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.forename: Ti
authors.initials: T
authors.lastname: Wang
authors.forename: Jue
authors.initials: J
authors.lastname: Ji
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: He
authors.initials: H
authors.lastname: Lin
authors.forename: Qizhong
authors.initials: Q
authors.lastname: Yi
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000328:Adult; D000818:Animals; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D020746:Calcium Channels, L-Type / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003627:Data Interpretation, Statistical; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D051379:Mice; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type