title: Hemostatic, antibacterial biopolymers from Acacia arabica (Lam.) Willd. and Moringa oleifera (Lam.) as potential wound dressing materials.
abstract: Acacia arabica and Moringa oleifera are credited with a number of medicinal properties. Traditionally gum of Acacia plant is used in the treatment of skin disorders to soothe skin rashes, soreness, inflammation and burns while Moringa seed extracts are known to have antibacterial activity. In the present study the potential of the polymeric component of aqueous extracts of gum acacia (GA) and the seeds of M. oleifera (MSP) in wound management was evaluated. The results revealed that both biopolymers were hemostatic and hasten blood coagulation. They showed shortening of activated partial thromboplastin time and prothrombin time and were non-cytotoxic in nature. Both showed antibacterial activity against organisms known to be involved in wound infections with MIC ranging from 500-600 microg mL(-1) for GA and 300-700 microg mL(-1) for MSP. They were biodegradable and exhibited water absorption capacity in the range of 415 to 935%. The hemostatic character coupled to these properties envisions their potential in preparation of dressings for bleeding and profusely exuding wounds. The biopolymers have been further analysed for their composition by Gas chromatography.
authors.affiliation: Algae Biofuel and Biomolecules Centre, Department of Microbiology, M.D.S., University, Ajmer 305 009, India. monicaajmer@gmail.com
authors.forename: Monica
authors.initials: M
authors.lastname: Bhatnagar
authors.forename: Laxmi
authors.initials: L
authors.lastname: Parwani
authors.forename: Vinay
authors.initials: V
authors.lastname: Sharma
authors.forename: Jhuma
authors.initials: J
authors.lastname: Ganguli
authors.forename: Ashish
authors.initials: A
authors.lastname: Bhatnagar
mesh_terms: D000045:Acacia / Q000737:chemistry; D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001458:Bandages; D002522:Chlorocebus aethiops; D006490:Hemostatics / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D029588:Moringa oleifera / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000008:administration & dosage / Q000494:pharmacology; D014709:Vero Cells; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D006490:Hemostatics; D010936:Plant Extracts; D011108:Polymers