title: Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion.
abstract: Cancer invasion is a complex process requiring, among other events, extensive remodeling of the extracellular matrix including deposition of pro-migratory and pro-proliferative moieties. In recent years, it has been described that while invading through matrices cancer cells can change shape and adapt their migration strategies depending on the microenvironmental context. Although intracellular signaling pathways governing the mesenchymal to amoeboid migration shift and vice versa have been mostly elucidated, the extracellular signals promoting these shifts are largely unknown. In this review, we summarize findings that point to matrikines that bind specifically to the EGF receptor as matricellular molecules that enable cancer cell migrational plasticity and promote invasion.
authors.affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, Pittsburgh, PA, USA.
authors.forename: Jelena
authors.initials: J
authors.lastname: Grahovac
authors.affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, Pittsburgh, PA, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Wells
mesh_terms: D002465:Cell Movement / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D066246:ErbB Receptors