title: Covalently coupled immunostimulant heterodimers.
abstract: We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.
authors.affiliation: Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA).
authors.forename: Rock J
authors.initials: RJ
authors.lastname: Mancini
authors.forename: Janine K
authors.initials: JK
authors.lastname: Tom
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Esser-Kahn
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D010766:Phosphorylation; D011108:Polymers / Q000737:chemistry*; D015398:Signal Transduction
chemical_list: D000276:Adjuvants, Immunologic; D011108:Polymers
keywords: bioconjugation; dendritic cells; heterotelechelic polymers; immunology; vaccines