title: Pyoderma gangrenosum in a patient with common variable primary immunodeficiency.
abstract: Pyoderma gangrenosum is a rare inflammatory skin condition that is associated with systemic inflammatory diseases. It is characterised by the presence of well-secluded, painful ulcerations, often located on the lower limbs. Similarly as in the case of acne inversa, patients' markers of the inflammatory process are elevated; including OB, C-reactive protein and leukocytosis. The aetiology takes into account an over-reactive inflammatory response to various factors (presence of the so-called pathergy symptom). Common variable primary immunodeficiency (CVID) is a disease that is rather often recognized and affects about 1/10,000-100,000 individuals. It is a heterogeneous group of disorders of combined B-and T-cell dysfunction. The case is described of a 22-year-old man with pyoderma gangrenosum that coexisted with CVID.
authors.affiliation: Department of Dermatology, Silesian Medical University, Katowice, Poland. Head: Prof. Ligia Brzezińska-Wcisło MD, PhD.
authors.forename: Beata
authors.initials: B
authors.lastname: Bergler-Czop
authors.forename: Ligia
authors.initials: L
authors.lastname: Brzezińska-Wcisło
keywords: immunodeficiency; inflammation; pyoderma gangrenosum