title: Cholestatic liver disease.
abstract: The care of the patient with cholestasis hinges on identifying the etiology, treating reversible causes, and managing chronic cholestatic processes. PBC and PSC are important causes of chronic cholestasis, and are the most common causes of cholestatic liver disease. Effective therapy is available for patients with PBC, whereas none exists for patients with PSC. Awareness of the complications that may be associated with cholestasis and implementing the appropriate management are essential.
authors.affiliation: Cholestatic Liver Disease Study Group, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA. Electronic address: Gossard.andrea@mayo.edu.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Gossard
authors.forename: Jayant A
authors.initials: JA
authors.lastname: Talwalkar
mesh_terms: D001361:Avitaminosis / Q000209:etiology; D001660:Biliary Tract Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002779:Cholestasis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D003938:Diagnostic Techniques, Digestive System; D019468:Disease Management; D018450:Disease Progression; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology; D011537:Pruritus / Q000209:etiology / Q000628:therapy
keywords: Bile duct obstruction; Biliary tract disease; Cholestasis; Cholestatic liver disease; Primary biliary cirrhosis; Primary sclerosing cholangitis