title: Genetic polymorphisms of CYP2D6 oxidation in patients with autoimmune bullous diseases.
abstract: BACKGROUND
  Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases.
  
  
  OBJECTIVE
  To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous diseases induction.
  
  
  METHODS
  The study included 72 patients with autoimmune bullous diseases: 37 with pemphigoid, 21 with pemphigus, and 14 with dermatitis herpetiformis (DH). The CYP2D6 genotypes were analyzed by the polymerase chain reaction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  Relative risk of DH development for particular genotype carriers expressed by odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 4.2; p = 0.0104) and 2-fold higher for subjects with CYP2D6*4 (OR = 2.3; p = 0.0351).
  
  
  CONCLUSIONS
  The results of the present study show that the CYP2D6 oxidation polymorphism cannot be considered a risk factor for development of pemphigoid and pemphigus, however it might have an impact on dermatitis herpetiformis.
authors.affiliation: Department of Pharmacogenetics, Medical University of Lodz, Poland. Head: Prof. Jadwiga Skretkowicz.
authors.forename: Mariola
authors.initials: M
authors.lastname: Rychlik-Sych
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Baranska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Waszczykowska
authors.forename: Jolanta Dorota
authors.initials: JD
authors.lastname: Torzecka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zebrowska
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Skretkowicz
keywords: CYP2D6; dermatitis herpetiformis; genetic polymorphism; pemphigoid; pemphigus