title: Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury.
abstract: Basic fibroblast growth factor (bFGF) has proven useful for neural stem and progenitor cells during the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells (BMSCs). Endogenous bFGF expression levels increase during brain development and gradually diminish with aging. To date, few studies have been conducted on exogenous bFGF promoting BMSC transplantation‑mediated functional recovery in adult rats following traumatic brain injury (TBI). The results of the present study showed that BMSCs in the TBI cortex and dentate gyrus showed differentiation along the glial and neuronal lines, which are possibly enhanced by bFGF. The neuronal differentiation rate was not consistent with neurological functional recovery rate over time. bFGF may promote the transplantation‑mediated therapeutic effect of BMSCs more significantly and rapidly in rats following TBI, with a small proportion of differentiated neurons. In conclusion, exogenous bFGF functions as a booster of the transplantation‑mediated therapeutic effect of BMSCs following TBI.
authors.affiliation: Department of Neurosurgery, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Xi-Cai
authors.initials: XC
authors.lastname: Yi
authors.forename: Geng
authors.initials: G
authors.lastname: Guo
authors.forename: Qian-Fa
authors.initials: QF
authors.lastname: Long
authors.forename: Xiao-An
authors.initials: XA
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhong
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Fei
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D001930:Brain Injuries / Q000601:surgery*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D018891:Dentate Gyrus / Q000166:cytology; D004195:Disease Models, Animal; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function
chemical_list: D016222:Fibroblast Growth Factor 2