title: Blood pressure in adolescence, adipokines and inflammation in young adults. The rio de janeiro study.
abstract: BACKGROUND
  The impact of blood pressure (BP) during adolescence on other cardiovascular risk factors in young adults is important for the primary prevention.
  
  
  OBJECTIVE
  To evaluate BP, anthropometric indexes, metabolic and inflammatory profiles in young individuals stratified by their BP behavior recorded for 18 years.
  
  
  METHODS
  A total of 116 individuals, of whom 63 were males, from the Rio de Janeiro study (follow-up of 17.76 ± 1.63 years), were assessed at two moments: A1 (12.40 ± 1.49 years) and A2 (30.09 ± 2.01 years). The 116 individuals were divided into two groups: GN (n = 71), of participants with normal BP at A1; and GH (n = 45), of those with abnormal BP at A1. BP, weight, height and body mass index (BMI) were measured at A1 and A2. At A2, abdominal circumference (AC) and laboratory, metabolic and inflammatory variables were included.
  
  
  RESULTS
  1) No difference was observed between the groups as regards age and gender; 2) At A2, GH showed higher mean weight, BMI, BP, insulin, HOMA-IR (p < 0.001), leptin (p < 0.02), apolipoprotein B100 and A1 (p < 0.02), apolipoprotein B100 / apolipoprotein A1 ratio (p < 0.010); and higher prevalences of overweight/obesity (p < 0.001), of increased AC (p < 0.001) and of hypertension (p < 0.02); 3) No difference was observed between the groups as regards the inflammatory variables; 4) There was a positive correlation of BP at A1 with BP, BMI, insulin, leptin and HOMA-IR at A2 (p < 0.05).
  
  
  CONCLUSIONS
  BP in adolescence was associated with higher values of BP, and anthropometric and metabolic variables in young adulthood, but not with inflammatory variables.
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Erika Maria Gonçalves
authors.initials: EM
authors.lastname: Campana
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Andréa Araujo
authors.initials: AA
authors.lastname: Brandão
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzan
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Maria Eliane Campos
authors.initials: ME
authors.lastname: Magalhães
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Flávia Lopes
authors.initials: FL
authors.lastname: Fonseca
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Oswaldo Luiz
authors.initials: OL
authors.lastname: Pizzi
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Elizabete Viana de
authors.initials: EV
authors.lastname: Freitas
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brasil.
authors.forename: Ayrton Pires
authors.initials: AP
authors.lastname: Brandão
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000886:Anthropometry; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D001938:Brazil; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D012016:Reference Values; D012307:Risk Factors; D055815:Young Adult
chemical_list: D054392:Adipokines; D001053:Apolipoproteins; D018836:Inflammation Mediators