title: WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist.
abstract: The opiate antagonist WIN 44,441-3 is a potent, stereospecific antagonist of mu, delta, and kappa opiate receptors. This antagonist activity is of long duration (> 4 h) with no agonist activity being observed. It therefore appears that WIN 44,441-3 will be a useful long-acting opiate antagonist for in vivo studies.
authors.affiliation: Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, H4H 1R3, Canada.
authors.forename: P L
authors.initials: PL
authors.lastname: Wood
authors.forename: C
authors.initials: C
authors.lastname: Pilapil
authors.forename: M
authors.initials: M
authors.lastname: Thakur
authors.forename: J W
authors.initials: JW
authors.lastname: Richard