title: Copper-mediated radical trifluoromethylation of unsaturated potassium organotrifluoroborates.
abstract: Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Marc
authors.initials: M
authors.lastname: Presset
authors.forename: Daniel
authors.initials: D
authors.lastname: Oehlrich
authors.forename: Frederik
authors.initials: F
authors.lastname: Rombouts
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
mesh_terms: D001881:Borates / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*
chemical_list: D001881:Borates; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D003300:Copper; D011188:Potassium