title: Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.
abstract: Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs irreversibly inhibit acetylcholinesterase (AChE) at nerve synapses. Furthermore, the role of AChE other than neurotransmission termination has been defined in the literature. The growing evidences show that cholinergic mechanisms are involved during growth and development of other organ systems. In contrary to the fact, the data on the use of oxime-AChER in OPC poisoning in pregnancy are scanty. The present review aimed to comprehend the status of oximes in pregnancy in lieu of the published literature. A thorough literature search was performed in January 2013, using ten popular search engines including Medline/PubMed, Google scholar, etc., using nine standard keywords. The search period was set from 1966 to present. The search did not reveal substantial data. No considerable studies were retrieved which could really demonstrate either the beneficial, harmful or even null effect of oxime-AChER usage in pregnancy. Only eighteen relevant articles were obtained for a period of about 47 years. In the literature, there is no report available to demonstrate the risk of using oxime-AChER in pregnancy for the treatment of OPC poisoning. The study reveals that the use of oxime-AChER in pregnancy is largely un-addressed, inconclusive and based on speculation albeit the incidences of OPC poisoning are quite prevalent. Well-designed studies are warranted for a tangible conclusion.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine and Health Science, United Arab Emirates University, P.O. Box 17666, Al Ain, UAE.
authors.forename: Syed M
authors.initials: SM
authors.lastname: Nurulain
authors.forename: Tekes
authors.initials: T
authors.lastname: Kornelia
authors.forename: Syed Naimul Hassan
authors.initials: SN
authors.lastname: Naqvi
authors.forename: Charu
authors.initials: C
authors.lastname: Sharma
authors.forename: Shreesh
authors.initials: S
authors.lastname: Ojha
authors.forename: Abdu
authors.initials: A
authors.lastname: Adem
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D062025:Organophosphate Poisoning / Q000188:drug therapy*; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D000931:Antidotes; D002801:Cholinesterase Reactivators; D010091:Oximes; D011220:Pralidoxime Compounds; C028797:pralidoxime