title: Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.
abstract: Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
authors.affiliation: Animal Health and Veterinary Laboratories Agency (AHVLA) Weybridge, Addlestone, Surrey, United Kingdom.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Vickery
authors.forename: Richard
authors.initials: R
authors.lastname: Lockey
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Holder
authors.forename: Leigh
authors.initials: L
authors.lastname: Thorne
authors.forename: Katy E
authors.initials: KE
authors.lastname: Beck
authors.forename: Christina
authors.initials: C
authors.lastname: Wilson
authors.forename: Margaret
authors.initials: M
authors.lastname: Denyer
authors.forename: John
authors.initials: J
authors.lastname: Sheehan
authors.forename: Sarah
authors.initials: S
authors.lastname: Marsh
authors.forename: Paul R
authors.initials: PR
authors.lastname: Webb
authors.forename: Ian
authors.initials: I
authors.lastname: Dexter
authors.forename: Angela
authors.initials: A
authors.lastname: Norman
authors.forename: Emma
authors.initials: E
authors.lastname: Popescu
authors.forename: Amanda
authors.initials: A
authors.lastname: Schneider
authors.forename: Paul
authors.initials: P
authors.lastname: Holden
authors.forename: Peter C
authors.initials: PC
authors.lastname: Griffiths
authors.forename: Jane M
authors.initials: JM
authors.lastname: Plater
authors.forename: Mark P
authors.initials: MP
authors.lastname: Dagleish
authors.forename: Stuart
authors.initials: S
authors.lastname: Martin
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Telling
authors.forename: Marion M
authors.initials: MM
authors.lastname: Simmons
authors.forename: John
authors.initials: J
authors.lastname: Spiropoulos
mesh_terms: D000818:Animals; D002417:Cattle; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology; D003670:Deer / Q000378:metabolism*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D016643:Encephalopathy, Bovine Spongiform / Q000378:metabolism* / Q000473:pathology / Q000635:transmission; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011328:Prions / Q000378:metabolism*; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000378:metabolism* / Q000473:pathology / Q000635:transmission
chemical_list: D011328:Prions