title: Markers of endothelial dysfunction and evaluation of vascular reactivity tests in Behçet disease.
abstract: We assessed endothelial dysfunction (ED) in patients with Behcet disease (BD; n=40) and healthy controls (n=20). Serum lipid, homocysteine, asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hsCRP) levels, erythrocyte sedimentation rates (ESRs), and ultrasonographic flow-mediated dilatation (FMD) were measured. Mean hsCRP, ESR, homocysteine, and ADMA were significantly higher in the BD group (P<.001 for all). Patients with active BD had higher serum levels of hsCRP, homocysteine, and ESR compared with those in remission (P<.001, P<.001, and P=.005, respectively). Flow-mediated dilatation was significantly lower in patients with BD than in controls (P=.001). Flow-mediated dilatation correlated negatively with BD duration and serum ADMA levels (P<.001, r=-.745 and P<.001, r=-.682); a positive correlation was seen between serum ADMA levels and BD duration (P<.001, r=.552). Only stepwise multivariate regression analysis revealed BD duration to have a significant effect on FMD. Flow-mediated dilatation, in conjunction with markers of inflammation, may evaluate ED in patients with BD.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kocatepe University, Afyon Turkey pozoguz@gmail.com.
authors.forename: Pinar
authors.initials: P
authors.lastname: Ozuguz
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
authors.forename: Ayse Anil
authors.initials: AA
authors.lastname: Karabulut
authors.affiliation: Department of Cardiology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tulmac
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
authors.forename: Ucler
authors.initials: U
authors.lastname: Kisa
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
authors.forename: Mukadder
authors.initials: M
authors.lastname: Kocak
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunduz
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001528:Behcet Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014463:Ultrasonography; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D008055:Lipids; D006710:Homocysteine; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Behcet disease; asymmetric dimethylarginine; endothelial dysfunction; flow-mediated dilatation; high-sensitivity C-reactive protein; homocysteine