title: Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population.
abstract: OBJECTIVE
  Fatty acid-binding proteins (FABPs) are a family of 14-15-kDa proteins, and some FABPs have been to be used as biomarkers of tissue injury by leak from cells. However, recent studies have shown that FABPs can be secreted from cells into circulation. Here we examined determinants and roles of circulating FABPs in a general population.
  
  
  METHODS
  From the database of the Tanno-Sobetsu Study, a study with a population-based cohort design, data in 2011 for 296 subjects on no medication were retrieved, and FABP1~5 in their serum samples were assayed.
  
  
  RESULTS
  Level of FABP4, but not the other isoforms, showed a gender difference, being higher in females than in males. Levels of all FABPs were negatively correlated with estimated glomerular filtration rate (eGFR), but a distinct pattern of correlation with other clinical parameters was observed for each FABP isoform; significant correlates were alanine aminotransferase (ALT), blood pressure (BP), and brain natriuretic peptide (BNP) for FABP1, none besides eGFR for FABP2, age, BP, and BNP for FABP3, age, waist circumference (WC), BP, BNP, lipid variables, high-sensitivity C-reactive protein (hsCRP), and HOMA-R for FABP4, and age, WC, BP, ALT, BNP, and HOMA-R for FABP5. FABP4 is the most strongly related to metabolic markers among FABPs. In a multivariate regression analysis, FABP4 level was an independent predictor of HOMA-R after adjustment of age, gender, WC, BP, HDL cholesterol, and hsCRP.
  
  
  CONCLUSIONS
  Each FABP isoform level showed a distinct pattern of correlation with clinical parameters, although levels of all FABPs were negatively determined by renal function. Circulating FABP4 appears to be a useful biomarker for detecting pre-clinical stage of metabolic syndrome, especially insulin resistance, in the general population.
authors.affiliation: Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Shutaro
authors.initials: S
authors.lastname: Ishimura
authors.forename: Masato
authors.initials: M
authors.lastname: Furuhashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hoshina
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fuseya
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Mita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Koyama
authors.forename: Marenao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Saitoh
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D062486:Public Health Surveillance; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins