title: CAPER 2.0: an interactive, configurable, and extensible workflow-based platform to analyze data sets from the Chromosome-centric Human Proteome Project.
abstract: The Chromosome-centric Human Proteome Project (C-HPP) aims to map and annotate the entire human proteome by the "chromosome-by-chromosome" strategy. As the C-HPP proceeds, the increasing volume of proteomic data sets presents a challenge for customized and reproducible bioinformatics data analyses for mining biological knowledge. To address this challenge, we updated the previous static proteome browser CAPER into a higher version, CAPER 2.0 - an interactive, configurable and extensible workflow-based platform for C-HPP data analyses. In addition to the previous visualization functions of track-view and heatmap-view, CAPER 2.0 presents a powerful toolbox for C-HPP data analyses and also integrates a configurable workflow system that supports the view, construction, edit, run, and share of workflows. These features allow users to easily conduct their own C-HPP proteomic data analyses and visualization by CAPER 2.0. We illustrate the usage of CAPER 2.0 with four specific workflows for finding missing proteins, mapping peptides to chromosomes for genome annotation, integrating peptides with transcription factor binding sites from ENCODE data sets, and functionally annotating proteins. The updated CAPER is available at http://www.bprc.ac.cn/CAPE.
authors.affiliation: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , 33 Life Science Park Road, Beijing 100850, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Zhongyang
authors.initials: Z
authors.lastname: Liu
authors.forename: Feifei
authors.initials: F
authors.lastname: Guo
authors.forename: Lihong
authors.initials: L
authors.lastname: Diao
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Xinlei
authors.initials: X
authors.lastname: Zhang
authors.forename: Zechi
authors.initials: Z
authors.lastname: Huang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
mesh_terms: D002877:Chromosomes, Human; D030562:Databases, Protein; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval; D020543:Proteome; D012984:Software
chemical_list: D020543:Proteome