title: Lipoprotein(a): a promising marker for residual cardiovascular risk assessment.
abstract: Atherosclerotic cardiovascular diseases (CVD) are still the leading cause of morbidity and mortality worldwide, although optimal medical therapy has been prescribed for primary and secondary preventions. Residual cardiovascular risk for some population groups is still considerably high although target low density lipoprotein-cholesterol (LDL-C) level has been achieved. During the past few decades, compelling pieces of evidence from clinical trials and meta-analyses consistently illustrate that lipoprotein(a) (Lp(a)) is a significant risk factor for atherosclerosis and CVD due to its proatherogenic and prothrombotic features. However, the lack of effective medication for Lp(a) reduction significantly hampers randomized, prospective, and controlled trials conducting. Based on previous findings, for patients with LDL-C in normal range, Lp(a) may be a useful marker for identifying and evaluating the residual cardiovascular risk, and aggressively lowering LDL-C level than current guidelines' recommendation may be reasonable for patients with particularly high Lp(a) level.
authors.affiliation: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
authors.forename: Anping
authors.initials: A
authors.lastname: Cai
authors.forename: Liwen
authors.initials: L
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yujin
authors.initials: Y
authors.lastname: Mo
authors.forename: Weiyi
authors.initials: W
authors.lastname: Mai
authors.forename: Yingling
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D015415:Biomarkers; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)