title: Evidence for regulation of oxidative stress by latent membrane protein 1 oncoprotein in patients with low-grade leukemic B cell lymphoma with latent Epstein-Barr virus infection.
abstract: The role of latent Epstein-Barr virus (EBV) infection in the pathogenesis of low-grade B cell non-Hodgkin lymphoma (B-NHL) has not been studied. We therefore investigated the incidence of latent EBV infection in a group of patients with leukemic low-grade B-NHL, as well as the incidence of viral latent membrane protein 1 (LMP1) oncoprotein expression in the same patient group. Furthermore, in an attempt to elucidate the role of this viral oncoprotein in non-EBV-related lymphomas, we correlated the expression of LMP1 with the level of oxidative stress, a parameter related to apoptosis. In the present study we detected lower levels of oxidative stress in the sera of LMP1-positive patients. This possibly implies an anti-apoptotic role of this viral oncoprotein in low-grade B cell lymphomas. However, LMP1 expression status did not affect expression of the major anti-apoptotic gene BCL-2.
authors.affiliation: Hematology Unit, 1st Department of Internal Medicine, Laikon General Hospital, University of Athens , Athens , Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Papadopoulou
authors.forename: Panagiotis T
authors.initials: PT
authors.lastname: Diamantopoulos
authors.forename: Elina
authors.initials: E
authors.lastname: Kontandreopoulou
authors.forename: Katerina
authors.initials: K
authors.lastname: Polonyfi
authors.forename: Eleni
authors.initials: E
authors.lastname: Variami
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kouzis
authors.forename: Athanasios
authors.initials: A
authors.lastname: Galanopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Spanakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zervakis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Iliakis
authors.forename: Despoina
authors.initials: D
authors.lastname: Perrea
authors.forename: Panagoula
authors.initials: P
authors.lastname: Kollia
authors.forename: Theodoros P
authors.initials: TP
authors.lastname: Vassilakopoulos
authors.forename: Gerassimos A
authors.initials: GA
authors.lastname: Pangalis
authors.forename: Christine
authors.initials: C
authors.lastname: Kyrtsonis
authors.forename: George
authors.initials: G
authors.lastname: Vaiopoulos
authors.forename: Nora-Athina
authors.initials: NA
authors.lastname: Viniou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D045022:Lactate Dehydrogenases / Q000097:blood; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D015513:Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014763:Viral Matrix Proteins; D045022:Lactate Dehydrogenases
keywords: Lymphoma and Hodgkin disease; lymphocytes; lymphoid leukemia