title: Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity.
abstract: The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis.
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia. Electronic address: elpach@mail.ru.
authors.forename: L P
authors.initials: LP
authors.lastname: Churilov
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Stroev
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Serdyuk
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Kaminova-Mudzhikova
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Belyaeva
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Gvozdetsky
authors.affiliation: Medical Faculty, Saint Petersburg State University, Russia; Research Institute of Phthisiopulmonology, Saint Petersburg, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Nitsa
authors.affiliation: Research Institute of Phthisiopulmonology, Saint Petersburg, Russia.
authors.forename: L R
authors.initials: LR
authors.lastname: Mikhailova
keywords: Adolescents; Autoimmune thyroiditis; Cytokines; Leptin; Marfanoid phenotype; Metabolic syndrome; Obesity; Prolactin; Transforming growth factor