title: [Serological assessment of Helicobacter pylori-specific antibodies and their association with gastric lesions in a high-risk population].
abstract: OBJECTIVE
  To determine the distributions of six Helicobacter pylori (Hp)-specific antibodies in a high-risk population of gastric cancer (GC) and explore the relationship between Hp virulence factors and precancerous gastric lesions.
  
  
  METHODS
  Based on the two intervention trials conducted in Linqu County, the seropositivities for CagA, VacA, GroEL, UreA, HcpC and GGT were assessed by recombinant immunoassay (recomLine) in 623 participants with H. pylori infection determined by (13)C-urea breath test ((13)C-UBT) and/or enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  In a total of 623 participants were detected by recomLine analysis, of which 594 were Hp-positive. The seropositivities rates of CagA, VacA, GroEL, UreA, HcpC and GGT were 84.0%, 38.2%, 66.7%, 17.7%, 58.8% and 42.8%, respectively. A total of 523 participants were determined as type I infection of Hp, accounting for 88.1%. Compared with superficial gastritis (SG), the infection rate of Hp type I was higher in the chronic atrophic gastritis (CAG) (P = 0.001).
  
  
  CONCLUSIONS
  The results of this population-based study suggest that the virulence factors of Hp may be related to the development of GC in a Chinese high-risk population. The recomLine analysis may serve as a tool for identification of Hp strains and prediction of high-risk population of GC.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Wang
authors.forename: Zhe-xuan
authors.initials: ZX
authors.lastname: Li
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Ma
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Wei-cheng
authors.initials: WC
authors.lastname: You
authors.forename: Kai-feng
authors.initials: KF
authors.lastname: Pan
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D005756:Gastritis / Q000097:blood / Q000276:immunology / Q000382:microbiology; D005757:Gastritis, Atrophic / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000097:blood* / Q000276:immunology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D013274:Stomach Neoplasms / Q000097:blood / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial