title: Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide.
abstract: Several semi interpenetrating network (SIPN) type hydrogels were synthesized by in-situ free radical crosslink copolymerization of acrylamide and crosslinker N,N'-methylene bisacrylamide (MBA) in aqueous solution of sodium alginate (SA).These SIPN hydrogels were characterized by FTIR, NMR SEM, DTA-TGA, XRD, PZC and also by swelling characteristics and network parameters. Adsorption (loading) and release of acetaminophen drug were studied with these hydrogels. Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix.
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta 92, A.P.C. Road, Kolkata 700009, India.
authors.forename: Himadri Sekhar
authors.initials: HS
authors.lastname: Samanta
authors.forename: Samit Kumar
authors.initials: SK
authors.lastname: Ray
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D000464:Alginates / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared; D000099166:Polyacrylamides
chemical_list: D000082:Acetaminophen; D000178:Acrylamides; D000180:Acrylic Resins; D000464:Alginates; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D020100:Hydrogels; D000099166:Polyacrylamides; C021221:N,N'-methylenebisacrylamide
keywords: Acrylamide; Characterization; Drug release; Semi-IPN hydrgels; Sodium alginate