title: Immunotherapy in lung cancer: "b7-bombers" and other new developments.
abstract: Several recent immunotherapy agents have exhibited exceptional activity, and their eventual approval for use in lung cancer appears plausible. The immune checkpoint proteins, such as the B7 superfamily, are becoming increasingly relevant targets for therapeutic inhibition. Tumor vaccines hold the potential to deliver durable responses that are specific for tumor antigen, with favorable adverse effect profiles. Several vaccine trials are accruing more patients than any previous lung cancer trials and are designed to select a specific population based on a predefined, scientifically justified biomarker. These emerging immune treatments may hold great potential for the systemic treatment of lung cancers.
authors.affiliation: Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
authors.forename: Ben C
authors.initials: BC
authors.lastname: Creelan
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Antonia
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D060887:B7 Antigens / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D018579:Patient Selection
chemical_list: D000951:Antigens, Neoplasm; D060887:B7 Antigens; D014408:Biomarkers, Tumor; D019496:Cancer Vaccines