title: [Allergic adverse transfusion reactions in paediatrics, a 3-year study].
abstract: OBJECTIVE
  In the transfused patients, in France, in 2011, allergy ranked as the third adverse transfusion reaction. In order to evaluate the incidence and symptomatology of allergic adverse transfusion reactions in the paediatric people, a study was performed.
  
  
  METHODS
  It was focused on patients under 18years of age cared for in hospitals of the Rhone-Alpes area. The national haemovigilance database (e-FIT) reports of allergic transfusion reactions were reviewed.
  
  
  RESULTS
  From January 1st 2009 to December 31st 2011, among 2,165 reports, 141 (6.5%) adverse transfusion reaction reports were collected in paediatric patients. Sixty-eight (48.2%) indicated allergic reactions and corresponded to 64 recipients. As regards clinical manifestations, forty-eight (70.6%) indicated cutaneous signs only, 3 (4.4%) mentioned pulmonary signs only and 9 (13.2%) reported both. Urticaria was observed in 38 cases (55.9%). Bronchospasm was notified in 4 cases but there was no angioedema. As for the severity of reactions, one adverse transfusion reaction was severe (grade 2) and 2 were life-threatening (grade 3). The most involved blood component was the apheresis platelet concentrate (40 cases, 58.8%) followed by the red blood cell concentrate (17 cases, 25.0%) and the methylene blue-treated fresh-frozen plasma (11 cases, 16.2%).
  
  
  CONCLUSIONS
  This study shows that among paediatric recipients, cutaneous signs are predominant in allergic adverse transfusion reactions and that the apheresis platelet concentrate is the most frequently involved blood component.
authors.affiliation: Service d'hémovigilance, Établissement français du sang Rhône-Alpes, site de Lyon-Gerland, 1-3, rue du Vercors, 69364 Lyon cedex 07, France. Electronic address: pierre.moncharmont@efs.sante.fr.
authors.forename: P
authors.initials: P
authors.lastname: Moncharmont
authors.forename: F
authors.initials: F
authors.lastname: Meyer
mesh_terms: D000293:Adolescent; D016913:Blood Component Transfusion / Q000009:adverse effects; D001787:Blood Group Incompatibility / Q000453:epidemiology*; D001986:Bronchial Spasm / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005076:Exanthema / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D007223:Infant; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology; D008297:Male; D011537:Pruritus / Q000453:epidemiology / Q000209:etiology; D012042:Registries; D012720:Severity of Illness Index; D065227:Transfusion Reaction; D014581:Urticaria / Q000453:epidemiology / Q000209:etiology
keywords: Adverse transfusion reaction; Allergie; Allergy; Effet indésirable; Paediatrics; Pédiatrie; Receveur; Recipient; Transfusion