title: Serum resistin levels are associated with adiposity and insulin sensitivity in obese Hispanic subjects.
abstract: OBJECTIVE
  Resistin is involved in the development of obesity and insulin resistance (IR) in mice and may play a similar role in humans through mechanisms that remain unresolved. The objective of this study was to characterize the relationship between resistin levels in obese subjects with and without IR among Hispanic subjects.
  
  
  METHODS
  A cross-sectional study was performed on 117 nondiabetic Hispanic subjects of both genders that were allocated into three study groups: A control group (n=47) of otherwise healthy individuals in metabolic balance, a group with obesity (OB) (n=36), and a group with obesity and IR (OB-IR) (n=34). Anthropometric and clinical characterization was carried out, and resistin levels were determined by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  We found that resistin levels were higher in OB and OB-IR groups when compared to the control group (1331.79±142.15 pg/mL, 1266.28±165.97 pg/mL vs. 959.21±171.43 pg/mL; P<0.05), an effect that was not confounded by age (control, 34.04±10.00 years; OB, 37.30±10.78 years; and OB-IR, 35.67±10.15 years). In addition, we observed a significant correlation (P<0.001) between resistin levels and higher adiposity and insulin sensitivity (IS) in our cohort.
  
  
  CONCLUSIONS
  Our results suggest that higher resistin levels are associated with higher adiposity and lower IS among obese Hispanic subjects.
authors.affiliation: 1 Posgrado en Ciencias Químicas, Benemérita Universidad Autónoma de Puebla (BUAP) , Puebla, México.
authors.forename: Adriana
authors.initials: A
authors.lastname: Nieva-Vazquez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pérez-Fuentes
authors.forename: Enrique
authors.initials: E
authors.lastname: Torres-Rasgado
authors.forename: José G
authors.initials: JG
authors.lastname: López-López
authors.forename: Jose R
authors.initials: JR
authors.lastname: Romero
mesh_terms: D050154:Adiposity / Q000208:ethnology; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology* / Q000378:metabolism*; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: C499624:RETN protein, human; D052243:Resistin