title: Idiopathic pulmonary fibrosis in West Highland white terriers.
abstract: Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial lung disease affecting mainly middle-aged and old West Highland white terriers. Other dogs, especially terriers, have been diagnosed with the disease. The cause is largely unknown, but it is likely to arise from interplay between genetic and environmental factors. CIPF shares several features with human idiopathic pulmonary fibrosis. This article summarizes the current literature; describes the findings in physical examination, arterial blood gas analysis, bronchoscopy, bronchoalveolar lavage, diagnostic imaging, and histopathology; compares the canine and human diseases; gives an overview of potential treatments; and discusses biomarker research.
authors.affiliation: Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Viikintie 49), Helsinki 00014, Finland. Electronic address: henna.laurila@helsinki.fi.
authors.forename: Henna P
authors.initials: HP
authors.lastname: Heikkilä-Laurila
authors.forename: Minna M
authors.initials: MM
authors.lastname: Rajamäki
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D020022:Genetic Predisposition to Disease; D054990:Idiopathic Pulmonary Fibrosis / Q000235:genetics / Q000473:pathology / Q000628:therapy / Q000662:veterinary*
keywords: Arterial blood gases; Biomarker; Bronchoalveolar lavage; Dog; HRCT; Interstitial lung disease