title: Edwards Sapien XT valve placement as treatment option for aortic regurgitation after transfemoral CoreValve implantation: a multicenter experience.
abstract: Transcatheter aortic valve replacement (TAVI), though a preferred treatment option in the elderly population carrying increased risks for open heart surgery, may result in prognosis-limiting moderate or severe aortic regurgitation. Here, we report a series of 11 patients from 3 German TAVI centers, suffering from moderate- to high-grade aortic regurgitation after CoreValve implantation, who were subsequently treated by Edwards Sapien XT implantation.
  
  
  METHODS
  The patients were 79.5 ± 4.2 years of age and presented between November 2009 and February 2013 with a symptomatic high-grade aortic stenosis (mean maximum gradient 57 ± 22 mmHg) and EuroSCORE of 16 ± 7%. Initial implantation of a Medtronic CoreValve resulted in moderate-to-severe aortic regurgitation (grade 2.64 ± 0.37) although postdilatation was attempted in eight cases and snare repositioning was attempted in one case.
  
  
  RESULTS
  All 11 patients were treated by a Sapien XT (Edwards) valve implanted into the initially deployed CoreValve: four via transfemoral, one via transaortical and six via transapical approaches. Successful implantation was possible in all 11 patients resulting in a reduction of aortic regurgitation to mean grade 0.23 ± 0.39. Two patients required permanent pacemaker. After 30 days, ten patients were alive, whereas one patient succumbed to pneumonia complicating advanced chronic obstructive pulmonary disease.
  
  
  CONCLUSIONS
  In the instance of moderate or severe aortic regurgitation after TAVI of a CoreValve, transfemoral or transapical Sapien XT valve-in-valve deployment is an excellent option to reduce residual regurgitation to none or mild.
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Diemert
authors.forename: Philipp
authors.initials: P
authors.lastname: Lange
authors.forename: Martin
authors.initials: M
authors.lastname: Greif
authors.forename: Moritz
authors.initials: M
authors.lastname: Seiffert
authors.forename: Lenard
authors.initials: L
authors.lastname: Conradi
authors.forename: Steffen
authors.initials: S
authors.lastname: Massberg
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Hermann
authors.initials: H
authors.lastname: Reichenspurner
authors.forename: Christian
authors.initials: C
authors.lastname: Hagl
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.forename: Holger
authors.initials: H
authors.lastname: Schröfel
authors.forename: Hendrik
authors.initials: H
authors.lastname: Treede
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schymik
authors.forename: Christian
authors.initials: C
authors.lastname: Kupatt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D018618:Echocardiography, Doppler, Color; D005260:Female; D005263:Femoral Artery; D005858:Germany; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome