title: Beyond survival; influences of blood pressure, cerebral perfusion and anesthesia on neurodevelopment.
abstract: Neonates have a higher perioperative mortality risk largely due to the degree of prior illness of the infants, the complexity of their surgeries, and infant physiology. It is important to consider contributing anesthetic factors during the perioperative period that may affect cerebral perfusion and neurocognitive outcome, such as alterations in hemodynamics and ventilation. Limitations of blood pressure as a marker for cerebral perfusion are discussed, as well as the effect of hypocapnia on the brain.
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: McCann
authors.forename: Anton N J
authors.initials: AN
authors.lastname: Schouten
mesh_terms: D000758:Anesthesia / Q000379:methods*; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D001923:Brain Chemistry / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002657:Child Development; D006706:Homeostasis; D006801:Humans; D016857:Hypocapnia / Q000097:blood / Q000145:classification; D007022:Hypotension / Q000150:complications / Q000523:psychology; D007231:Infant, Newborn; D009420:Nervous System / Q000254:growth & development*; D013534:Survival
keywords: blood pressure; general anesthesia; hypocapnia; ischemic encephalopathy; newborn infant; premature infant