title: Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study.
abstract: BACKGROUND
  Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.
  
  
  METHODS
  In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.
  
  
  RESULTS
  In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.
  
  
  CONCLUSIONS
  Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.
authors.affiliation: Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany, christoph.sinning@t-online.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Sinning
authors.forename: Till
authors.initials: T
authors.lastname: Keller
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.forename: Francisco
authors.initials: F
authors.lastname: Ojeda
authors.forename: Michael
authors.initials: M
authors.lastname: Schlüter
authors.forename: Renate
authors.initials: R
authors.lastname: Schnabel
authors.forename: Edith
authors.initials: E
authors.lastname: Lubos
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Lackner
authors.forename: Patrick
authors.initials: P
authors.lastname: Diemert
authors.forename: Thomas
authors.initials: T
authors.lastname: Munzel
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Wild
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D059168:Carotid Intima-Media Thickness; D015150:Echocardiography, Doppler; D005260:Female; D005858:Germany / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011237:Predictive Value of Tests; D013318:Stroke Volume; D019210:Troponin I / Q000097:blood*; D059289:Vascular Stiffness; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D019210:Troponin I