title: Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives.
abstract: A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.
authors.affiliation: Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1. jmcnult@mcmaster.ca.
authors.forename: James
authors.initials: J
authors.lastname: McNulty
authors.forename: Ramesh
authors.initials: R
authors.lastname: Vemula
authors.forename: Claudia
authors.initials: C
authors.lastname: Bordón
authors.forename: Robert
authors.initials: R
authors.lastname: Yolken
authors.forename: Lorraine
authors.initials: L
authors.lastname: Jones-Brando
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000187:drug effects*; D014123:Toxoplasmosis / Q000188:drug therapy*
chemical_list: D000981:Antiprotozoal Agents; D011804:Quinolines