title: Effects of antiepileptic drugs on sexual function and reproductive hormones of male epileptic patients.
abstract: BACKGROUND
  Diminished libido and sexual dysfunction are unusually common among male epileptic patients. The most important etiologic factor may be antiepileptic drugs (AEDs)-induced androgen deficiency. We compared reproductive hormone levels among men with epilepsy taking various AEDs and normal controls.
  
  
  METHODS
  Subjects were 59 male epileptic patients who aged 24 ± 5 years. They had been receiving lamotrigine (LTG) (n = 17), carbamazepine (CBZ) (n = 18), and sodium valproate (VPA) (n = 15) for at least 6 months. We also recruited 23 healthy controls. Testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), androstenedione (AND), luteinizing hormone (LH), and follicle stimulatin hormone (FSH) levels and gonadal efficiency (testosterone/LH) were compared between the four groups. The patients and the control group were examined and evaluated for male reproduction by urology and endocrinology services.
  
  
  RESULTS
  Subjects receiving CBZ, VPA, and LTG had significantly lower mean testosterone levels than the control group (P < 0.01). In addition, patients receiving LTG had significantly higher mean testosterone levels than CBZ and VPA groups (P < 0.01) and controls (P < 0.05). There were not any significant differences between the groups in mean estradiol levels. The mean AND level in VPA was higher than CBZ, LTG, and control groups (P < 0.01). Men receiving CBZ had significantly lower DHEAS levels than the other groups (P < 0.01). Testosterone/LH ratio in the control group was more than other groups (P < 0.01). On the other hand, this value in LTG group was higher than CBZ and VPA groups (P < 0.01). However, CBZ and VPA groups were not significantly different in terms of testosterone/LH ratio.
  
  
  CONCLUSIONS
  Although the mean levels of reproductive hormones were lower in the LTG group compared to the controls, among traditional antiepileptic drugs, LTG had fewer side effects on reproductive hormones. Therefore, it is a good adjuvant and substitute drug for epilepsy control instead of CBZ and VPA.
authors.affiliation: Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan AND Isfahan Neuroscience Research Center, Isfahan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Najafi
authors.forename: Behnaz
authors.initials: B
authors.lastname: Ansari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zare
authors.forename: Farzad
authors.initials: F
authors.lastname: Fatehi
authors.forename: Ali
authors.initials: A
authors.lastname: Sonbolestan
keywords: Antiepileptic Drugs; Epilepsy; Male Reproduction; Sexual Function