title: Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters.
abstract: An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University , 3663 North Zhongshan Rd., Shanghai 200062, China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Ma
authors.forename: Dong
authors.initials: D
authors.lastname: Xing
authors.forename: Changwei
authors.initials: C
authors.lastname: Zhai
authors.forename: Jiuwei
authors.initials: J
authors.lastname: Che
authors.forename: Shunying
authors.initials: S
authors.lastname: Liu
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003979:Diazonium Compounds / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000588:Amines; D003979:Diazonium Compounds; D004952:Esters; D008665:Metalloporphyrins; D007501:Iron; C032111:diazoacetic ester