title: Fixated on fixation: using ChIP to interrogate the dynamics of chromatin interactions.
abstract: A new study exploits the time-dependence of formaldehyde cross-linking in the commonly used chromatin immunoprecipitation (ChIP) assay to infer the on and off rates for site-specific chromatin interactions.
authors.forename: Leeat
authors.initials: L
authors.lastname: Keren
authors.forename: Eran
authors.initials: E
authors.lastname: Segal
mesh_terms: D002843:Chromatin / Q000737:chemistry* / Q000235:genetics; D047369:Chromatin Immunoprecipitation / Q000379:methods*; D003432:Cross-Linking Reagents; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D005557:Formaldehyde / Q000737:chemistry; D005656:Fungal Proteins / Q000235:genetics; D011401:Promoter Regions, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014157:Transcription Factors
chemical_list: D002843:Chromatin; D003432:Cross-Linking Reagents; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D014157:Transcription Factors; D005557:Formaldehyde