title: Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats.
abstract: The effect of oleic acid vesicles (ufasomes) on the intestinal absorption of entrapped carboxyfluo-rescein (CF) was investigated by an in situ closed-loop method in rats. Entrapment of CF in ufasomes enhanced the absorption of CF at the earlier stage following intraduodenal administration, and the threshold concentration of the fatty acid for promoting the absorption of CF was approximately 8 mM. The absorption of CF from the large intestine was promoted much more effectively than from the small intestine. These studies suggest that ufasomes have potential as carriers for the oral administration of poorly absorbable drugs.
authors.affiliation: Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: S
authors.initials: S
authors.lastname: Muranishi