title: DNA translocation through hydrophilic nanopore in hexagonal boron nitride.
abstract: Ultra-thin solid-state nanopore with good wetting property is strongly desired to achieve high spatial resolution for DNA sequencing applications. Atomic thick hexagonal boron nitride (h-BN) layer provides a promising two-dimensional material for fabricating solid-state nanopores. Due to its good oxidation resistance, the hydrophilicity of h-BN nanopore device can be significantly improved by UV-Ozone treatment. The contact angle of a KCl-TE droplet on h-BN layer can be reduced from 57° to 26° after the treatment. Abundant DNA translocation events have been observed in such devices, and strong DNA-nanopore interaction has been revealed in pores smaller than 10 nm in diameter. The 1/f noise level is closely related to the area of suspended h-BN layer, and it is significantly reduced in smaller supporting window. The demonstrated performance in h-BN nanopore paves the way towards base discrimination in a single DNA molecule.
authors.affiliation: Beijing National Laboratory for Condensed-Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xu
authors.forename: Wenlong
authors.initials: W
authors.lastname: Wang
authors.forename: Xuedong
authors.initials: X
authors.lastname: Bai
authors.forename: Xinyan
authors.initials: X
authors.lastname: Shan
authors.forename: Xinghua
authors.initials: X
authors.lastname: Lu
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004560:Electricity; D004566:Electrodes; D057927:Hydrophobic and Hydrophilic Interactions; D058608:Nanopores; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry; D017422:Sequence Analysis, DNA; D014466:Ultraviolet Rays
chemical_list: D001896:Boron Compounds; C017282:boron nitride; D010126:Ozone; D004247:DNA