title: Viral agents causing acute lower respiratory tract infections in hospitalized children at a tertiary care center in Saudi Arabia.
abstract: OBJECTIVE
  To determine the load and importance of respiratory viruses in hospitalized Saudi children with acute lower respiratory tract infections (ALRIs).
  
  
  METHODS
  A retrospective study was performed at the Departments of Pediatrics, Pathology/Microbiology, King Khalid University Hospital, Kingdom of Saudi Arabia from January 2005 to December 2010. Nasopharyngeal aspirates were collected from 643 children with ALRI. Viruses were detected by direct immunofluorescence, respiratory syncytial virus (RSV), adenovirus (ADV), type 1 to 3 parainfluenza viruses (PIV), and type A and B influenza virus (flu).
  
  
  RESULTS
  Of the 643 children with ALRI, viruses were detected in 309 (48.1%) specimens. The viruses that were identified included RSV (n=295, 95.5%), PIV (n=8, 1.2%), ADV (n=2, 0.3%), flu A (n=2, 0.3%), and flu B (n=2, 0.3%). The RSV was predominated in 231 (75%) children less than one year of age. Only younger age and male gender were associated with severe illness. The peak frequency of the viruses detected was in the winter. Of the 309 virus positive samples, bronchiolitis was detected in 81.2% (n=251), and pneumonia in 14.2% (n=44) (p<0.0001).
  
  
  CONCLUSIONS
  Viruses are an important cause of ALRIs in Saudi children constituting approximately 48.1% of the total cases. The RSV is the most common pathogen (95.5%) causing ALRIs. Most of the children were younger than one year of age, and were more likely to present with bronchiolitis than pneumonia.
authors.affiliation: Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh 11461, PO Box 2925, Kingdom of Saudi Arabia. Tel. +966 (11) 4679963. Fax +966 (11) 4691512. E-mail: ebukhari@ksu.edu.sa.
authors.forename: Elham E
authors.initials: EE
authors.lastname: Bukhari
authors.forename: Malak M
authors.initials: MM
authors.lastname: Elhazmi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D012529:Saudi Arabia / Q000453:epidemiology; D062606:Tertiary Care Centers; D014777:Virus Diseases / Q000453:epidemiology*