title: Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats.
abstract: Aqueous extract of C. longa when administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade and aqueous humor (AH) protein level compared to vehicle treated group. Although, prednisolone group showed significantly lower clinical grade, histopathological grades and AH protein levels compared to C. longa group, TNF-alpha levels did not differ significantly. Moreover, when the aqueous extract was administered starting from 3 days before induction of uveitis, the mean clinical and histopathological grade as well as AH protein and TNF-alpha levels were comparable to C. longa group when treatment was administered 4 h after induction of uveitis. It is concluded that topically applied standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity.
authors.affiliation: Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector 3, M B Road, New Delhi 110 017, India. renu@salam.uitm.edu.my
authors.forename: Renu
authors.initials: R
authors.lastname: Agarwal
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Puneet
authors.initials: P
authors.lastname: Agarwal
authors.forename: Sushma
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D000287:Administration, Topical; D000818:Animals; D030024:Curcuma / Q000737:chemistry / Q000502:physiology; D004731:Endotoxins; D009883:Ophthalmic Solutions / Q000592:standards; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D014867:Water / Q000494:pharmacology
chemical_list: D004731:Endotoxins; D009883:Ophthalmic Solutions; D010936:Plant Extracts; D014867:Water; C044101:endotoxin, Escherichia coli