title: The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association.
abstract: In reconsolidation studies, memories are typically retrieved by an exposure to a single conditioned stimulus (CS). We have previously demonstrated that reconsolidation processes are CS-selective, suggesting that memories retrieved by the CS exposure are discrete and reconsolidate separately. Here, using a compound stimulus in which two distinct CSs are concomitantly paired with the same aversive unconditioned stimulus (US), we show in rats that reexposure to one of the components of the compound CS triggers extinction or reconsolidation of the other component. This suggests that the original training conditions play a critical role in memory retrieval and reconsolidation.
authors.affiliation: W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA.
authors.forename: Jacek
authors.initials: J
authors.lastname: Debiec
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Diaz-Mataix
authors.forename: David E A
authors.initials: DE
authors.lastname: Bush
authors.forename: Valérie
authors.initials: V
authors.lastname: Doyère
authors.forename: Joseph E
authors.initials: JE
authors.lastname: LeDoux
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D005239:Fear / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin