title: Gene polymorphisms and chronic obstructive pulmonary disease.
abstract: The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large-sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD.
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Respiratory Research Institute, Shanghai, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wu
authors.forename: Bowei
authors.initials: B
authors.lastname: Yuan
authors.forename: Elena
authors.initials: E
authors.lastname: López
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
mesh_terms: D018450:Disease Progression; D004851:Epoxide Hydrolases / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D000515:alpha 1-Antitrypsin / Q000235:genetics
chemical_list: D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D000515:alpha 1-Antitrypsin; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases
keywords: COPD; biomarkers; chronic lung diseases; gene; polymorphism; therapy