title: STK15 rs2273535 polymorphism and cancer risk: a meta-analysis of 74,896 subjects.
abstract: BACKGROUND
  It has been suggested that the serine/threonine kinase 15 (STK15) T91A rs2273535 polymorphism is associated with susceptibility to cancer. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship.
  
  
  METHODS
  PubMed was searched to select studies. Case-control studies containing available genotype frequencies of the STK15 rs2273535 polymorphism were chosen, and the odds ratio (OR) with its 95% confidence interval (CI) was utilized to assess the strength of association.
  
  
  RESULTS
  52 studies - including 34,057 cases and 40,839 controls - were identified. A significant effect of the STK15 rs2273535 polymorphism on cancer risk was found (AA vs. TT: OR=1.13, 95%CI=1.01-1.26, Pheterogeneity<0.001; AA vs.
  OR=1.12, 95%CI=1.02-1.22, Pheterogeneity<0.001; TA/AA vs. TT: OR=1.06, 95%CI=1.01-1.12, Pheterogeneity<0.001). Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs.
  OR=1.24, 95%CI=1.05-1.47, Pheterogeneity=0.124), and esophageal cancer (AA vs.
  OR=1.19, 95%CI=1.02-1.39, Pheterogeneity=0.148). Further subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (AA vs.
  OR=1.20, 95%CI=1.05-1.37, Pheterogeneity=0.004).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the STK15 rs2273535 polymorphism is a candidate gene polymorphism for cancer susceptibility, especially in Asian populations.
authors.affiliation: The Fourth Clinical College of Nanjing Medical University, China; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Oncology, First Clinical College of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. Electronic address: xulin83cn@gmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. Electronic address: yinhero001@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Yin
mesh_terms: D064096:Aurora Kinase A / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C576917:AURKA protein, human; D064096:Aurora Kinase A
keywords: Cancer; Meta-analysis; Polymorphism; STK15