title: Heritable equine regional dermal asthenia.
abstract: Hereditary equine regional dermal asthenia is a form of Ehlers-Danlos syndrome, and has an autosomal recessive mode of inheritance. Affected horses are typically born normal and develop lesions within the first 2 years of life. The most common symptoms of the disease include stretchy, loose skin that feels doughy or mushy. More severely affected horses experience spontaneous skin sloughing and extensive lacerations, hematomas, and seromas from minor trauma. Affected horses have a higher than expected incidence of corneal ulcers. DNA testing can normal, establish carrier and affected status. Palliative therapy is available, but no curative treatment exists.
authors.affiliation: Department of Large Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, Room A116, East Lansing, MI 48824, USA. Electronic address: rashmir@cvm.msu.edu.
authors.forename: Ann
authors.initials: A
authors.lastname: Rashmir-Raven
mesh_terms: D000818:Animals; D001247:Asthenia / Q000235:genetics / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006736:Horses; D012873:Skin Diseases, Genetic / Q000235:genetics / Q000473:pathology / Q000628:therapy / Q000662:veterinary*
keywords: Collagen; DNA testing; HERDA; Hereditary; Quarter Horse; Skin tearing