title: Molecular diagnostics in the neoplasms of the pancreas, liver, gall bladder, and extrahepatic biliary tract.
abstract: Pancreatic neoplasms, including ductal adenocarcinoma, intraductal papillary mucinous neoplasm, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and ampullary carcinoma, are associated with different genetic abnormalities. Liver neoplasms, including hepatic adenomas, hepatocellular carcinomas, and cholangiocarcinomas, are associated with identifiable risk factors and genetic changes. Gall bladder adenomas and adenocarcinomas arise from distinct molecular pathways. The molecular abnormalities seen in these tumors are not used routinely in the molecular diagnostic laboratory.
authors.affiliation: Department of Pathology, Detroit Medical Center, Karmanos Cancer Center, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Weindel
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zulfiqar
authors.forename: Amarpreet
authors.initials: A
authors.lastname: Bhalla
authors.forename: Vinod B
authors.initials: VB
authors.lastname: Shidham
mesh_terms: D004067:Digestive System Neoplasms / Q000175:diagnosis*; D006801:Humans; D025202:Molecular Diagnostic Techniques; D057089:Pathology, Molecular
keywords: Extrahepatic biliary tract; Gall bladder adenocarcinoma; Gall bladder adenoma; Liver neoplasms; Molecular diagnostics; Pancreatic neoplasms