title: Antihypertensive and Diuretic Effects of the Aqueous Extract of Colocasia esculenta Linn. Leaves in Experimental Paradigms.
abstract: Colocasia esculenta Linn (CE) is traditionally used for the treatment of various ailments such as high blood pressure, rheumatic pain, pulmonary congestion, etc. Hence in present study, the effect of aqueous extract of CE leaves (AECE) was evaluated for antihypertensive and acute diuretic activity in rats. Preliminary phytochemical evaluation revealed the presence of carbohydrate, saponins, tannins, and flavonoids in AECE. The animals did not show any sign of toxicity and mortality after the administration of AECE 2000 mg/Kg in acute oral toxicity study. The administration of AECE (100, 200, and 400 mg/Kg/day, p.o.) for six weeks and AECE (10, 20, and 40 mg/Kg, IV) on the day of experiment in renal artery-occluded hypertensive rats and AECE (20 and 40 mg/Kg, IV) in noradrenalin-induced hypertension in rats produced significant (p < 0.05) anti-hypertensive effects. AECE (400 mg/Kg, p.o.) showed positive diuretic activity at 5 h. AECE (200 and 400 mg/Kg, p.o.) significantly increased sodium and chloride content of urine in 5 h and 24 h and additionally potassium in 24 h urine. Hence, the results of the present study revealed the antihypertensive and weak diuretic activity of AECE. These effects may be attributed due to the ACE inhibitory, vasodilatory, β-blocking, and/ or Ca(2+) channel blocking activities, which were reported for the phytoconstitunts, specifically flavonoids such as vitexin, isovitexin, orientin, and isoorientin present in the leaves of CE.
authors.affiliation: Department of Pharmacology, Rajgad Dyanpeeth's College of Pharmacy, Bhor, Dist: Pune, India-412 206, Maharashtra, India.
authors.forename: Otari Kishor
authors.initials: OK
authors.lastname: Vasant
authors.forename: Bhalsing Gaurav
authors.initials: BG
authors.lastname: Vijay
authors.forename: Shete Rajkumar
authors.initials: SR
authors.lastname: Virbhadrappa
authors.forename: Nandgude Tanaji
authors.initials: NT
authors.lastname: Dilip
authors.forename: Mali Vishal
authors.initials: MV
authors.lastname: Ramahari
authors.forename: Bodhankar Subhash
authors.initials: BS
authors.lastname: Laxamanrao
keywords: Antihypertensive; Colocasia esculenta Linn; Diuretic; Flavonoids; Noradrenaline; Renal artery-occluded hypertension