title: Successful treatment of recurrent metastatic nasopharyngeal carcinoma with oxaliplatin and doxorubicin.
abstract: Nasopharyngeal carcinoma (NPC) is a rare tumor in children and often presents as advanced-stage disease. NPC in children is treated with neoadjuvant chemotherapy and radiotherapy. The prognosis for children who relapse after treatment is extremely poor. This report describes the successful treatment and long-term disease-free survival of a 16-year-old male patient with a history of stage IVA NPC, who recurred with pulmonary and hepatic metastases. The patient was treated with a novel combination of oxaliplatin and doxorubicin without irradiation.
authors.affiliation: *Division of Hematology/Oncology, Children's Hospital Los Angeles †Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
authors.forename: Leo
authors.initials: L
authors.lastname: Mascarenhas
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011379:Prognosis; D012074:Remission Induction
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D004317:Doxorubicin