title: Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction.
abstract: The fruit of Schisandra chinensis has been used in the traditional Chinese medicine for thousands of years. Accumulating evidence suggests that Schisandrin B (Sch B) has cardioprotection effect on myocardial ischemia in vitro. However, it is unclear whether Sch B has beneficial effects on continuous myocardial ischemia in vivo. The aim of the present study was to investigate whether Sch B could improve cardiac function and attenuate myocardial remodeling after myocardial infarction (MI) in mice. Mice model of MI was established by permanent ligation of the left anterior descending (LAD) coronary artery. Then the MI mice were randomly treated with Sch B or vehicle alone. After treatment for 3 weeks, Sch B could increase survival rate, improve heart function and decrease infarct size compared with vehicle. Moreover, Sch B could down-regulate some inflammatory cytokines, activate eNOS pathway, inhibit cell apoptosis, and enhance cell proliferation. Further in vitro study on H9c2 cells showed similar effects of Sch B on prevention of hypoxia-induced inflammation and cell apoptosis. Taken together, our results demonstrate that Sch B can reduce inflammation, inhibit apoptosis, and improve cardiac function after ischemic injury. It represents a potential novel therapeutic approach for treatment of ischemic heart disease.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Pengsheng
authors.initials: P
authors.lastname: Chen
authors.forename: Sisi
authors.initials: S
authors.lastname: Pang
authors.forename: Naiquan
authors.initials: N
authors.lastname: Yang
authors.forename: Haoyu
authors.initials: H
authors.lastname: Meng
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Ningtian
authors.initials: N
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Zhengxian
authors.initials: Z
authors.lastname: Tao
authors.forename: Liansheng
authors.initials: L
authors.lastname: Wang
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D034242:Cyclooctanes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000188:drug therapy*; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D032141:Schisandra / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C015499:schizandrin B