title: Simple and compelling biomimetic metal-organic framework catalyst for the degradation of nerve agent simulants.
abstract: Inspired by biology, in which a bimetallic hydroxide-bridged zinc(II)-containing enzyme is utilized to catalytically hydrolyze phosphate ester bonds, the utility of a zirconium(IV)-cluster-containing metal-organic framework as a catalyst for the methanolysis and hydrolysis of phosphate-based nerve agent simulants was examined. The combination of the strong Lewis-acidic Zr(IV) and bridging hydroxide anions led to ultrafast half-lives for these solvolysis reactions. This is especially remarkable considering that the actual catalyst loading was a mere 0.045 % as a result of the surface-only catalysis observed.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA).
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Katz
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Mondloch
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Totten
authors.forename: Jin K
authors.initials: JK
authors.lastname: Park
authors.forename: Sonbinh T
authors.initials: ST
authors.lastname: Nguyen
authors.forename: Omar K
authors.initials: OK
authors.lastname: Farha
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Hupp
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry; D002384:Catalysis; D002619:Chemical Warfare Agents / Q000737:chemistry*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D009420:Nervous System / Q000187:drug effects; D009942:Organometallic Compounds / Q000737:chemistry*; D044345:Phosphoric Triester Hydrolases / Q000737:chemistry; D016062:Porosity; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001952:Bridged-Ring Compounds; D002619:Chemical Warfare Agents; D009942:Organometallic Compounds; D015040:Zirconium; D044345:Phosphoric Triester Hydrolases; D015032:Zinc
keywords: coordination polymers; heterogeneous catalysis; hydrolysis; metal-organic frameworks; nerve agents