title: Familial papular epidermal nevus with "skyline" basal cell layer.
abstract: Papular epidermal nevus with "skyline" basal cell layer (PENS), a novel keratinocytic nevus, has recently been described as a mosaic condition with varying presentations. We herein describe typical PENS lesions, which usually occur sporadically, affecting two members of the same family. The concept of paradominant inheritance is proposed to explain the paradox of occasional transmission of normally sporadically occurring traits.
authors.affiliation: Section of Dermatology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Department of Pathophysiology and Transplantation, University of Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Brena
authors.forename: Francesca
authors.initials: F
authors.lastname: Besagni
authors.forename: Vinicio
authors.initials: V
authors.lastname: Boneschi
authors.forename: Gianluca
authors.initials: G
authors.lastname: Tadini
mesh_terms: D001706:Biopsy; D004817:Epidermis / Q000473:pathology*; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D015603:Keratinocytes / Q000473:pathology*; D008297:Male; D009506:Nevus; D009508:Nevus, Pigmented / Q000235:genetics* / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult