title: Diuretic Potential of Whole Plant Extracts of Pergularia daemia (Forsk.).
abstract: The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs test. All extracts except the petroleum ether extract showed significant increase (p < 0.001) in urine output. Urinary electrolyte excretion was also affected by the extracts: the alcoholic, ethyl acetate and n-butanol extract caused an increase in the urinary excretion of sodium and potassium ions. These findings suggest that among the mentioned extracts, ethanolic has the maximum diuretic activity followed by n-butanol extract.
authors.affiliation: Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, India.
authors.forename: Vyas
authors.initials: V
authors.lastname: Bhavin
authors.forename: Vyas
authors.initials: V
authors.lastname: Ruchi
authors.forename: Santani
authors.initials: S
authors.lastname: Dd
keywords: Daemia extensa; Diuretic action; Diuretic activity; Electrolyte