title: IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease.
abstract: We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressing lymphoid cells was observed around the ectopic lymphoid foci in the affected urogenital tissues. To date, testicular involvement in a patient diagnosed with IgG4-RD had not been reported, making this the first reported case of IgG4-related epididymo-orchitis. These findings suggest that the immune mechanism underlying ectopic lymphoneogenesis in IgG4-RD may involve enhanced BAFF/BAFF-R interactions among lymphoid cells.
authors.affiliation: Department of General Internal Medicine and Rheumatology, Clinical Research Center, NHO Nagasaki Medical Center , 2-1001-1 Kubara, Omura 856-8652 , Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Miyashita
authors.forename: Aya
authors.initials: A
authors.lastname: Mizuno
authors.forename: Yuka
authors.initials: Y
authors.lastname: Jiuchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsuo
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeoka
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.forename: Mikio
authors.initials: M
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D053265:B-Cell Activation Factor Receptor; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D009920:Orchitis / Q000150:complications* / Q000276:immunology; D011467:Prostate / Q000276:immunology; D013737:Testis / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000276:immunology
chemical_list: D053265:B-Cell Activation Factor Receptor; D007074:Immunoglobulin G