title: MiR146a and MiR499 gene polymorphisms in Iranian periodontitis and peri-implantitis patients.
abstract: OBJECTIVE
  MicroRNAs (MiRs) are small noncoding RNAs that are involved in protein translation, osteoclastogenesis, and immunoregulation. Peri-implantitis and chronic periodontitis are multifactorial diseases. They are the consequence of complex interactions among host response, genetics, and environment. In the present study, we aimed to investigate the possible association between MiR146a/MiR499 gene polymorphisms and periodontitis/peri-implantitis as a first report in oral implantology.
  
  
  METHODS
  From 197 individuals referred to Periodontology Department of Shahid Beheshti Dental School, three groups were enrolled in the assessment: 75 patients in the chronic periodontitis (CP) group, 38 patients in the peri-implantitis (PI) group, and 84 healthy subjects. DNA was extracted from fresh blood samples from the arm veins of participants and transferred to KBiosience Institute (Hoddesdon, United Kingdom) for genotyping. Chi-squared and Kruskal-Wallis tests were performed using SPSS software v.19 for statistical analyses. P-value < 0.05 was considered significant.
  
  
  RESULTS
  The genotype frequencies in MiR 146a and MiR 499 were significantly different among the three groups.
  
  
  CONCLUSIONS
  MiR146a (rs2910146) and MiR499 (rs3746444) gene polymorphisms may be genetic determinants for increased risk of chronic periodontitis and peri-implantitis in Iranians. More studies with larger sample sizes in different populations are necessary for determining the effect of these SNPs.
authors.affiliation: Periodontics Department, Dental School, Shahid Beheshti University of Medical Sciences, Daneshju Blvd., Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Kadkhodazadeh
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Jafari
authors.forename: Reza
authors.initials: R
authors.lastname: Amid
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Ebadian
authors.forename: Marjan Mohammad
authors.initials: MM
authors.lastname: Alipour
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mollaverdi
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Lafzi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D057873:Peri-Implantitis / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*