title: Mast cells respond to urticating extract from lepidoptera larva Morpheis ehrenbergii in the rat.
abstract: Mast cells and histamine participate in toxic effects of hairs from some caterpillars. This study reports that a crude extract of Morpheis ehrenbergii caterpillar hairs induces in vitro mast cells activation, triggers the release of histamine and causes a rapid urticarial reaction in the rat skin. Heating of the extract abolishes the inflammatory reaction. These results suggest that the use of antihistamines may improve the adverse skin reactions caused by the Mexican caterpillar M. ehrenbergii.
authors.affiliation: Laboratory of Immunology, Department of Microbiology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, C.P. 20131 Aguascalientes, Mexico.
authors.forename: María Fernanda
authors.initials: MF
authors.lastname: Galicia-Curiel
authors.affiliation: Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, C.P. 20131 Aguascalientes, Mexico.
authors.forename: J Luis
authors.initials: JL
authors.lastname: Quintanar
authors.affiliation: Laboratory of Immunology, Department of Microbiology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, C.P. 20131 Aguascalientes, Mexico.
authors.forename: Mariela
authors.initials: M
authors.lastname: Jiménez
authors.affiliation: Laboratory of Immunology, Department of Microbiology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, C.P. 20131 Aguascalientes, Mexico. Electronic address: emsalin@correo.uaa.mx.
authors.forename: Eva
authors.initials: E
authors.lastname: Salinas
mesh_terms: D000818:Animals; D002080:Butterflies / Q000737:chemistry*; D045424:Complex Mixtures / Q000008:administration & dosage / Q000032:analysis / Q000276:immunology / Q000633:toxicity*; D005070:Evans Blue; D006632:Histamine / Q000378:metabolism; D007271:Injections, Intradermal; D007814:Larva / Q000737:chemistry; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D012430:Ruthenium Red; D018675:Toxicity Tests; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D045424:Complex Mixtures; D012430:Ruthenium Red; D005070:Evans Blue; D006632:Histamine
keywords: Caterpillar; Histamine; Mast cells activation; Morpheis ehrenbergii; Urticarial reaction