title: Real-world costs of chronic lymphocytic leukaemia in the Netherlands.
abstract: We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) received ≥1 treatment lines during an average follow-up time of 6.4 years. The average total costs per patient were €41,417 (€539 per month). The costs varied considerably between treatment groups and between treatment lines. Although patients were treated with expensive chemo(immuno-)therapy, the main cost driver was inpatient days for other reasons than administration of chemo(immuno-)therapy.
authors.affiliation: Department of Health Policy & Management/Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands. Electronic address: goor@bmg.eur.nl.
authors.forename: K M
authors.initials: KM
authors.lastname: Holtzer-Goor
authors.affiliation: Department of Health Policy & Management/Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
authors.forename: C A M
authors.initials: CA
authors.lastname: Bouwmans-Frijters
authors.affiliation: Department of Haematology, Medisch Spectrum Twente, Enschede, The Netherlands.
authors.forename: M R
authors.initials: MR
authors.lastname: Schaafsma
authors.affiliation: Department of Haematology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
authors.forename: O
authors.initials: O
authors.lastname: de Weerdt
authors.affiliation: Department of Haematology, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Joosten
authors.affiliation: Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands; Department of Haematology, Reinier de Graaf Hospital, Delft, The Netherlands.
authors.forename: E F M
authors.initials: EF
authors.lastname: Posthuma
authors.affiliation: Department of Haematology, Meander Medical Center, Amersfoort, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Wittebol
authors.affiliation: Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: P C
authors.initials: PC
authors.lastname: Huijgens
authors.affiliation: Department of Haematology, Rijnstate Hospital, Arnhem, The Netherlands.
authors.forename: E J M
authors.initials: EJ
authors.lastname: Mattijssen
authors.affiliation: Department of Haematology, Máxima Medical Center, Veldhoven, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Vreugdenhil
authors.affiliation: Department of Haematology, Medical Center Alkmaar, Alkmaar, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Visser
authors.affiliation: Department of Haematology, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.
authors.forename: W G
authors.initials: WG
authors.lastname: Peters
authors.affiliation: Department of Haematology, OZG Delfzicht Ziekenhuis, Delfzijl, The Netherlands.
authors.forename: Z
authors.initials: Z
authors.lastname: Erjavec
authors.affiliation: Department of Haematology, Haga Hospital, Den Haag, The Netherlands.
authors.forename: P W
authors.initials: PW
authors.lastname: Wijermans
authors.affiliation: Department of Haematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: S M G J
authors.initials: SM
authors.lastname: Daenen
authors.affiliation: Department of Haematology, Zaans Medisch Centrum, Zaandam, The Netherlands.
authors.forename: K G
authors.initials: KG
authors.lastname: van der Hem
authors.affiliation: Department of Haematology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: M H J
authors.initials: MH
authors.lastname: van Oers
authors.affiliation: Department of Health Policy & Management/Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
authors.forename: C A Uyl-de
authors.initials: CA
authors.lastname: Groot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D003955:Diagnostic Tests, Routine / Q000191:economics* / Q000379:methods; D004358:Drug Therapy / Q000191:economics* / Q000379:methods; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D033581:Stem Cell Transplantation / Q000191:economics* / Q000379:methods
keywords: Chronic lymphocytic leukaemia; Cost of illness; Costs; Observational study; Outcomes research; Real-world