title: Effects of multimerization on the temporal variability of protein complex abundance.
abstract: We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of these functional units, response time of a gene, and temporal correlation between the numbers of expressed proteins and of the functional multimers. We show that, although multimerization increases noise by reducing the mean number of functional complexes it can reduce noise in comparison with a monomer, when abundance of the functional proteins are comparable. Alternatively, reduction in noise occurs if both monomeric and multimeric forms of the protein are functional. Moreover, we find that multimerization either increases the response time to external signals or decreases the correlation between number of functional complexes and protein production kinetics. Finally, we show that the results are in agreement with recent genome-wide assessments of cell-to-cell variability in protein numbers and of multimerization in essential and non-essential genes in Escherichia coli, and that the effects of multimerization are tangible at the level of genetic circuits.
authors.forename: Antti
authors.initials: A
authors.lastname: Häkkinen
authors.forename: Huy
authors.initials: H
authors.lastname: Tran
authors.forename: Olli
authors.initials: O
authors.lastname: Yli-Harja
authors.forename: Brian
authors.initials: B
authors.lastname: Ingalls
authors.forename: Andre S
authors.initials: AS
authors.lastname: Ribeiro
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D016680:Genome, Bacterial; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*; D055503:Protein Multimerization; D013997:Time Factors
chemical_list: D001426:Bacterial Proteins; D046912:Multiprotein Complexes