title: Tissue distribution comparison between healthy and fatty liver rats after oral administration of hawthorn leaf extract.
abstract: Hawthorn leaves, a well-known traditional Chinese medicine, have been widely used for treating cardiovascular and fatty liver diseases. The present study aimed to investigate the therapeutic basis treating fatty liver disease by comparing the tissue distribution of six compounds of hawthorn leaf extract (HLE) in fatty liver rats and healthy rats after oral administration at first day, half month and one month, separately. Therefore, a sensitive and specific HPLC method with internal standard was developed and validated to determine chlorogenic acid, vitexin-4''-O-glucoside, vitexin-2''-O-rhamnoside, vitexin, rutin and hyperoside in the tissues including heart, liver, spleen, kidney, stomach and intestine. The results indicated that the six compounds in HLE presented some bioactivity in treating rat fatty liver as the concentrations of the six compounds varied significantly in inter- and intragroup comparisons (healthy and/or fatty liver group).
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yin
authors.forename: Jianguo
authors.initials: J
authors.lastname: Qu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.forename: Dongrui
authors.initials: D
authors.lastname: Lu
authors.forename: Yucong
authors.initials: Y
authors.lastname: Gao
authors.forename: Xixiang
authors.initials: X
authors.lastname: Ying
authors.forename: Tingguo
authors.initials: T
authors.lastname: Kang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D027825:Crataegus / Q000737:chemistry*; D005234:Fatty Liver / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D010936:Plant Extracts
keywords: HPLC; fatty liver; hawthorn leaf extract (HLE); tissue distribution