title: Reimer-Tiemann adducts as potential insect antifeedant agents Reviewing the structure-activity relationship theory of the antifeedant, warburganal.
abstract: Structure-activity relationships of naturally occurring enedials with antifeedant activity againstSpodoptera species have been extended via the synthesis and bioassay of a series of Reimer-Tiemann adducts. The activities attributed to the different chemical structures of these and other analogs interacting with the chemoreceptor site have been observed; a three-pronged mode of substrate binding via aromatic pyrrole formation, Michael addition of free sulfhydryl moieties, and van der Waals interactions of the A ring has been postulated to account for these observations.
authors.affiliation: Insect Chemical Ecology Lab, Plant Sciences Institute, U.S. Department of Agriculture, Agricultural Research Service, 20705, Beltsville, Maryland.
authors.forename: G L
authors.initials: GL
authors.lastname: Fritz
authors.forename: G D
authors.initials: GD
authors.lastname: Mills
authors.forename: J D
authors.initials: JD
authors.lastname: Warthen
authors.forename: R M
authors.initials: RM
authors.lastname: Waters