title: Adverse events of intravenous immunoglobulin infusions: a ten-year retrospective study.
abstract: BACKGROUND
  Intravenous immunoglobulin (IVIG) is a biological product with adverse effects that appears to vary considerably among different IVIG preparations.
  
  
  OBJECTIVE
  To describe the adverse events of patients given intravenous immunoglobulin infusions.
  
  
  METHODS
  Data was collected on all patients receiving IVIG infusion at a tertiary hospital from January 2001 to December 2010. Descriptive statistics was used.
  
  
  RESULTS
  77 patients (45 males, 32 females) received IVIG infusions. Thirty two percent (n = 25) experienced adverse reactions. The most common indication was Kawasaki disease (85.7%) followed by immunodeficiency disorders (7.8%). Majority of the patients were children, with the highest frequency of infusions among those aged 2 to 8 years old (52%). 36 infusions were associated with occurrence of adverse effects. Fever was the most common adverse event (n = 11, 30.6%), followed by rash (n = 8, 22.2%) and chills (n = 7, 19.4%). Other adverse events were cyanosis (n = 3, 8.3%), hypotension (n = 2, 5.6%), hypothermia (n = 2, 5.6%), irritability (n = 1, 2.8%), vomiting (n = 1, 2.8%), and chest pain (n = 1, 2.8%). Adverse events were observed to occur most frequently within 1 to 6 h from onset of IVIG infusion. Among the various IVIG preparations available locally (Gammagard, Kiovig, Gamimune, Veno-S & IV Globulin S), Gammagard was the brand frequently used (50.7%). It also has the most number of adverse events, with 17 out of 41 (41.5%) infusions resulting in adverse reactions. Most of the reactions occurred with fast infusion rates, and clinical manifestations subsided when the rate of infusion was reduced.
  
  
  CONCLUSIONS
  In this study, thirty two percent of patients given IVIG infusions experienced adverse events. Fever was the most common manifestation. Symptoms occurred within 1 to 6 h from onset of infusion, were affected by fast infusion rates, and managed by reducing the rate of infusion.
authors.affiliation: Allergy, Asthma and Immunology Unit, Dr. Fe del Mundo Medical Center, Quezon City, Metro Manila 1100, Philippines.
authors.forename: Frances Rose R
authors.initials: FR
authors.lastname: Palabrica
authors.forename: Shirley L
authors.initials: SL
authors.lastname: Kwong
authors.forename: Florecita R
authors.initials: FR
authors.lastname: Padua
keywords: Intravenous immunoglobulins; Retrospective study; Side effects