title: The catalytic asymmetric α-benzylation of aldehydes.
abstract: The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany). list@mpi-muelheim.mpg.de.
authors.forename: Benjamin
authors.initials: B
authors.lastname: List
authors.forename: Ilija
authors.initials: I
authors.lastname: Čorić
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Grygorenko
authors.forename: Philip S J
authors.initials: PS
authors.lastname: Kaib
authors.forename: Igor
authors.initials: I
authors.lastname: Komarov
authors.forename: Anna
authors.initials: A
authors.lastname: Lee
authors.forename: Markus
authors.initials: M
authors.lastname: Leutzsch
authors.forename: Subhas
authors.initials: S
authors.lastname: Chandra Pan
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Tymtsunik
authors.forename: Manuel
authors.initials: M
authors.lastname: van Gemmeren
keywords: DYKATt; enamine catalysis; organocatalysis; α-alkylation; α-branched aldehydes