title: A practical route for the highly stereoselective synthesis of tetrasubstituted fluoroalkenes.
abstract: A series of tetrasubstituted fluoroalkene derivatives were synthesized by the reaction of α-fluoro-β-carbonyl benzothiazol-2-yl sulfones with various nucleophiles in good yields with high stereoselectivities. The predominant cis configuration of fluorine and alkynyl groups was observed. A single isomer was obtained when a ketone, acetate or amide was used as the substrate in the presence of a base.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai 200032, China. jtliu@sioc.ac.cn.
authors.forename: Chun-Ru
authors.initials: CR
authors.lastname: Cao
authors.forename: Song
authors.initials: S
authors.lastname: Ou
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Liu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry
chemical_list: D000475:Alkenes; D006845:Hydrocarbons, Fluorinated; D013450:Sulfones