title: Baseline thickness of macular ganglion cell complex predicts progression of visual field loss.
abstract: BACKGROUND
  Previous studies reported that the thickness of the macular ganglion cell complex (mGCC) showed good diagnostic ability for detecting glaucoma. However, its impact on the progression of visual field loss in primary open angle glaucoma (POAG) is unknown. The purpose of this study was to assess whether baseline mGCC thickness is associated with the progression of visual field loss in POAG.
  
  
  METHODS
  Fifty-six patients with POAG were included in the study. All patients were followed for more than 2 years after baseline optical coherence tomography (OCT) measurements. They had at least five reliable Humphrey visual field tests with 30-2 Swedish Interactive Threshold Algorithm standard tests during the follow-up period. The subjects were divided into two groups according to the slope of the mean deviation (MD): the fast progression group (MD slope < -0.4 dB/y) and the slow progression group (MD slope ≥ -0.4 dB/y). Factors compared between the groups were as follows: age, baseline intraocular pressure (IOP), mean IOP during the follow-up, refraction, baseline MD, pattern standard deviation (PSD), and baseline OCT measurements.
  
  
  RESULTS
  There were no significant differences between the two groups in age, baseline IOP, mean IOP during the follow-up, refraction, baseline MD or PSD, average thickness of retinal nerve fiber layer (RNFL), or disc parameters. However, the baseline mGCC thickness (average and inferior hemifield) was significantly thinner in the fast progression group than in the slow progression group (74.0 ± 7.2 μm vs. 80.3 ± 8.6 μm; 68.0 ± 6.6 μm vs. 78.2 ± 11.6 μm, respectively). Moreover, global loss volume and focal loss volume, which are parameters of mGCC, showed significantly higher rates in the fast progression group than in the slow progression group. In multivariate analysis, only mGCC thickness of the inferior hemifield was associated with disease progression (P = 0.007).
  
  
  CONCLUSIONS
  Baseline mGCC thickness can be predictive of progressive visual field loss in patients with POAG.
authors.affiliation: Department of Ophthalmology, Toho University Ohashi Medical Center, 2-17-6, Ohashi Meguro-ku, Tokyo, 153-8515, Japan, ayakoanraku@gmail.com.
authors.forename: Ayako
authors.initials: A
authors.lastname: Anraku
authors.forename: Nobuko
authors.initials: N
authors.lastname: Enomoto
authors.forename: Asuka
authors.initials: A
authors.lastname: Takeyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Goji
authors.initials: G
authors.lastname: Tomita
mesh_terms: D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests; D014794:Visual Fields