title: NaF-loaded core-shell PAN-PMMA nanofibers as reinforcements for Bis-GMA/TEGDMA restorative resins.
abstract: A kind of core-shell nanofibers containing sodium fluoride (NaF) was produced and used as reinforcing materials for dimethacrylate-based dental restorative resins in this study. The core-shell nanofibers were prepared by coaxial-electrospinning with polyacrylonitrile (PAN) and poly(methyl methacrylate) (PMMA) solutions as core and shell fluids, respectively. The produced PAN-PMMA nanofibers varied in fiber diameter and the thickness of PMMA shell depending on electrospinning parameters. NaF-loaded nanofibers were obtained by incorporating NaF nanocrystals into the core fluid at two loadings (0.8 or 1.0wt.%). Embedment of NaF nanocrystals into the PAN core did not damage the core-shell structure. The addition of PAN-PMMA nanofibers into Bis-GMA/TEGDMA clearly showed the reinforcement due to the good interfacial adhesion between fibers and resin. The flexural strength (Fs) and flexural modulus (Ey) of the composites decreased slightly as the thickness of PMMA shell increasing. Sustained fluoride releases with minor initial burst release were achieved from NaF-loaded core-shell nanofibers and the corresponding composites, which was quite different from the case of embedding NaF nanocrystals into the dental resin directly. The study demonstrated that NaF-loaded PAN-PMMA core-shell nanofibers were not only able to improve the mechanical properties of restorative resin, but also able to provide sustained fluoride release to help in preventing secondary caries.
authors.affiliation: Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Cheng
authors.forename: Xuegang
authors.initials: X
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhong
authors.forename: Xuliang
authors.initials: X
authors.lastname: Deng
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry*; D005459:Fluorides / Q000032:analysis; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*; D012964:Sodium / Q000032:analysis; D012969:Sodium Fluoride / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D011109:Polymethacrylic Acids; D012117:Resins, Synthetic; C020946:triethylene glycol dimethacrylate; C010504:polyacrylonitrile; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; D012969:Sodium Fluoride; D019904:Polymethyl Methacrylate; D012964:Sodium; D005459:Fluorides
keywords: Core–shell nanofibers; Dental resin; Fluoride-ion release; Nanocomposite