title: Self-disinfecting and microbiocide-impregnated surfaces and fabrics: what potential in interrupting the spread of healthcare-associated infection?
abstract: Innovative technologies have identified approaches to developing self-disinfecting surfaces or fabrics to minimize healthcare-associated infection (HCAI). These include altering the structure or surface to minimize the attachment of microbes or to delay the development of biofilm, using compounds that are activated in the presence of light to reduce the microbial burden, and incorporating a heavy metal such as silver or copper with intrinsic antimicrobial activity. Most technologies for surfaces and fabrics have been assessed in vitro and have been shown to reduce bacterial numbers by ≥2 logs. However, apart from copper -impregnated surfaces, there have been few trials in a clinical setting. Copper-impregnated surfaces result in reduced microbial surface counts on surfaces commonly found in clinical areas compared with controls, and 1 study has assessed HCAI and colonization rates. However, larger and better-designed studies are required to determine if these approaches augment current hygiene regimens, especially when these are optimally implemented.
authors.affiliation: Department of Clinical Microbiology, The Royal College of Surgeons in Ireland.
authors.forename: Hilary
authors.initials: H
authors.lastname: Humphreys
mesh_terms: D018441:Biofilms; D003300:Copper; D003428:Cross Infection / Q000517:prevention & control*; D004202:Disinfectants; D006801:Humans; D017053:Infection Control / Q000295:instrumentation / Q000379:methods*; D011092:Polyethylene Glycols; D011481:Protective Clothing; D013499:Surface Properties; D014025:Titanium
chemical_list: D004202:Disinfectants; C009495:titanium dioxide; D011092:Polyethylene Glycols; D003300:Copper; D014025:Titanium
keywords: biofilm; copper; decontamination and hospital hygiene; polyethylene glycol; titanium dioxide