title: In vitro antibiotic susceptibility of Francisella tularensis isolates from Japan.
abstract: The antibiotic susceptibilities of 36 isolates of Japanese Francisella tularensis, an etiological agent of the zoonotic disease tularemia, were analyzed using the E test. All the isolates were susceptible to ciprofloxacin, doxycycline, erythromycin, and gentamicin but resistant to benzylpenicillin and cephalothin. The susceptibility to seven other β-lactams (aztreonam, cefotaxime, cefoxitin, ceftriaxone, cefuroxime, imipenem, and meropenem) varied among the isolates. These findings suggest that the guidelines for the antibiotic treatment of tularemia issued by the World Health Organization are appropriate for Japanese tularemia patients.
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases.
authors.forename: Akitoyo
authors.initials: A
authors.lastname: Hotta
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Uda
authors.forename: Neekun
authors.initials: N
authors.lastname: Sharma
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tanabayashi
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akio
authors.initials: A
authors.lastname: Yamada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morikawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005604:Francisella tularensis / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D014406:Tularemia / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents