title: Association of perioperative allogeneic blood transfusions and prognosis of patients with gastric cancer after curative gastrectomy.
abstract: BACKGROUND
  The relationship between perioperative allogeneic blood transfusions (PABTs) and prognosis in patients with gastric cancer remains controversial.
  
  
  METHODS
  Six hundred five consecutive patients with gastric cancer who underwent curative gastrectomy from a single center were enrolled in this retrospective study. Clinical and pathologic variables were prospectively collected. The effect of PABT on the long-term survival of patients with gastric cancer after curative gastrectomy was evaluated by univariate and multivariate analyses.
  
  
  RESULTS
  The overall 5-year survival rate was 65.0%. On univariate analyses, PABT had a statistically significant negative impact on 3-year and 5-year survival rates (66.3% vs 80.5% [P = .005] and 38.7% vs 76.4% [P < .001], respectively). However, multivariate analyses revealed that duration of operation (P = .009), tumor size (P = .001), and tumor stage (P < .001), instead of PABT, were independent prognostic factors.
  
  
  CONCLUSIONS
  Our study indicates that PABT is not an independent prognostic factor for long-term survival in patients with gastric cancer after curative gastrectomy.
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yi
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China.
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, No 415, Fengyang Road, Shanghai 200003, China. Electronic address: czhuzq@aliyun.com.
authors.forename: Zhi-Qian
authors.initials: ZQ
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019990:Perioperative Care / Q000009:adverse effects*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D065227:Transfusion Reaction; D016896:Treatment Outcome
keywords: Allogeneic blood transfusions; Gastric cancer; Perioperative; Prognosis