title: Quercetin promotes glioma growth in a rat model.
abstract: We have previously demonstrated that quercetin (Quer), a polyphenol widely found in vegetables, decreased glioma cell growth in vitro. Here, we asked whether this compound could affect glioma growth in an in vivo rat glioma model. We found that daily intraperitoneal Quer (50 mg/kg) injections lead to a concentration of 0.15 μg of Quer per gram of brain tissue, which increased the tumor volume in a time dependent manner. We observed a small reduction in lymphocytic infiltration, a marker of good prognosis in gliomas that was accompanied by a small reduction in cell viability of peripheral T-cells. Moreover, after Quer treatment neither body weight alteration nor liver pathology markers were detected. Although in vitro studies and massive literature reports point to the antitumoral properties of Quer, the present results indicate that great caution has to be taken in the design of clinical trials and the indiscriminate use of this polyphenol as dietary supplement.
authors.affiliation: Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil; Universidade Federal da Fronteira Sul (UFFS), Campus Cerro Largo, Avenida Jacob Reinaldo Haupenthal, n 1580, Cerro Largo 97900-000, RS, Brazil. Electronic address: lauren.zamin@uffs.edu.br.
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Zamin
authors.affiliation: Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil.
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Filippi-Chiela
authors.affiliation: Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil.
authors.forename: Jose
authors.initials: J
authors.lastname: Vargas
authors.affiliation: Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil.
authors.forename: Diogo Ribeiro
authors.initials: DR
authors.lastname: Demartini
authors.affiliation: Departamento de Patologia, Hospital de Clínicas de Porto Alegre, UFRGS, Rua Ramiro Barcelos, n 2350, Porto Alegre 90035-903, RS, Brazil.
authors.forename: Luise
authors.initials: L
authors.lastname: Meurer
authors.affiliation: Faculdade de Biociências e Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga, n 6690, Porto Alegre 90610-900, RS, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Souza
authors.affiliation: Faculdade de Biociências e Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga, n 6690, Porto Alegre 90610-900, RS, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bonorino
authors.affiliation: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Avenida Ramiro Barcelos, n 2600, UFRGS, Porto Alegre 90035-003, RS, Brazil.
authors.forename: Christianne
authors.initials: C
authors.lastname: Salbego
authors.affiliation: Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil.
authors.forename: Guido
authors.initials: G
authors.lastname: Lenz
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005910:Glioma / Q000473:pathology*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011794:Quercetin
keywords: ALT; AST; C; DMEM; Dulbecco’s modified Eagle’s medium; GBM; Glioblastoma; In vivo glioma model; PHA; Quer; Quercetin; Tumor cell growth; alanine aminotransferase; aspartate aminotransferase; control; glioblastoma; phytohaemagglutinin; quercetin; γ-GT; γ-glutamyltransferase