title: Recent applications of basophil activation tests in the diagnosis of drug hypersensitivity.
abstract: Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic utilities, new indications, and methodological aspects of the basophil activation test for the diagnosis of drug hypersensitivity.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 100-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 100-799, Korea.
authors.forename: Woo-Jung
authors.initials: WJ
authors.lastname: Song
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Chang
keywords: Basophil activation test; Basophils; CD203c; CD63; Drug hypersensitivity; Immunologic tests