title: Screening of Korean Medicinal Plant Extracts for α-Glucosidase Inhibitory Activities.
abstract: Glycosidases are the enzymes involved in various biochemical processes related to metabolic disorders and diseases. Therefore, much effort has been focused on searching novel pharmacotherapy for the treatment of these ailments from medicinal plants due to higher safety margins. To pursue these efforts, the present study was performed to evaluate the α-glucosidase inhibitory activities of thirty Korean medicinal plant extracts. Among the plants studied, Euonymus sachalinensis, Rhododendron schlippenbachii, Astilbe chinensis and Juglans regia showed the strongest α-glucosidase inhibitory activity with IC50 values of 10, 20, 30 and 80 µg/mL, respectively. In addition, Meliosma oldhamii and Symplocos chinensis showed moderate α-glucosidase inhibition with IC50 values of 150 and 220 µg/mL, respectively. Therefore, they might prove to be a potential natural source for the treatment of metabolic ailments such as, diabetes, and need further investigations.
authors.affiliation: Department of Biology, Kongju National University, Kongju 314-701, Korea.
authors.forename: Shruti
authors.initials: S
authors.lastname: Sancheti
authors.forename: Sandesh
authors.initials: S
authors.lastname: Sancheti
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jae-Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Sung-Yum
authors.initials: SY
authors.lastname: Seo
keywords: Glycosidases; Korean plants; Screening; α-Glucosidase inhibitor