title: Metabolic effects of high doses of manganese in rats.
abstract: The effects of acute manganese (Mn) toxicity on tissue manganese concentrations and on plasma glucose levels were investigated in adult male Sprague-Dawley rats. Manganese injection in all tissues analyzed was reflected by a significant increase in Mn concentration that was transitory. Changes in the molecular localization of Mn in liver following injection include both increases in protein-bound Mn and low molecular weight Mn complexes. A rapid, dose-responsive rise in blood glucose followed Mn injection, whereas circulating insulin levels decreased after injection. These data show that acute changes in tissue Mn levels can have a pronounced effect on carbohydrate metabolism.
authors.affiliation: Department of Nutrition, University of California, 95616, Davis, California.
authors.forename: C L
authors.initials: CL
authors.lastname: Keen
authors.forename: D L
authors.initials: DL
authors.lastname: Baly
authors.forename: B
authors.initials: B
authors.lastname: Lönnerdal