title: Nutritional regulation of stem and progenitor cells in Drosophila.
abstract: Stem cells and their progenitors are maintained within a microenvironment, termed the niche, through local cell-cell communication. Systemic signals originating outside the niche also affect stem cell and progenitor behavior. This review summarizes studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila. Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within the niche. The concept of systemic control of these cell types is not limited to Drosophila and may be functional in vertebrate systems, including mammals.
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Shim
authors.forename: Shubha
authors.initials: S
authors.lastname: Gururaja-Rao
authors.forename: Utpal
authors.initials: U
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000166:cytology; D008297:Male; D015398:Signal Transduction / Q000235:genetics; D055153:Stem Cell Niche / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D007328:Insulin
keywords: Amino acid sensing; Dilp; Drosophila; Germline stem cell; Hematopoietic progenitor cell; Insulin; Intestinal stem cell; Neural stem cell; Nutritional control