title: Management of open wounds: lessons from orthopedic oncology.
abstract: The management of complex wounds remains a challenge, and although there have been many promising advances, patients often undergo a morbid and lengthy process to obtain sufficient, satisfactory healing. Sarcoma patients are especially vulnerable to soft tissue wound-healing complications. These patients are often treated with neoadjuvant radiation and/or chemotherapy and have compromised local vascularity to healing tissue. The advent and refinement of wound vacuum-assisted closure technology have been shown to have a tremendous impact. This article reviews the benefits of some novel technologies currently undergoing investigation in orthopedic oncology that will likely have applications in wound management from other causes.
authors.affiliation: Orthopaedic Oncology, University of Alabama at Birmingham Medical Center, Birmingham, AL, USA. Electronic address: hsiegel@uabmc.edu.
authors.forename: Herrick J
authors.initials: HJ
authors.lastname: Siegel
mesh_terms: D001458:Bandages; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D003646:Debridement / Q000379:methods; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D059351:Organ Sparing Treatments / Q000379:methods; D010027:Osteotomy / Q000009:adverse effects / Q000379:methods; D017063:Outcome Assessment, Health Care; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D012307:Risk Factors; D012509:Sarcoma / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D017695:Soft Tissue Injuries / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D013529:Surgical Wound Dehiscence / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D058106:Wound Closure Techniques / Q000145:classification*; D014945:Wound Healing
keywords: Hyperbaric oxygen treatment; Sarcoma; Silver dressings; Wound complications