title: The heart and pediatric rheumatology.
abstract: Recent advances in Kawasaki disease have included attempts to define genes involved in its pathogenesis. There have been recent advances in the studies of rheumatic carditis, leading to a better understanding of the mechanism of the disease. Histologic evaluation of patients with neonatal lupus erythematosus has revealed fibrosis with collagen deposition and calcification of the atrioventricular node. Therapy for cardiac involvement in systemic juvenile idiopathic arthritis should involve treatment of the underlying disease and systemic inflammatory state, and typically includes nonsteroidal antiinflammatory drugs, corticosteroids, disease-modifying drugs, and biologic therapies targeting tumor necrosis factor-alpha, interleukin-1, and interleukin-6.
authors.affiliation: Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, Box 8116, One Children's Place, St Louis, MO 63110, USA; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: Tiphanie
authors.initials: T
authors.lastname: Vogel
authors.forename: Maleewan
authors.initials: M
authors.lastname: Kitcharoensakkul
authors.forename: Lampros
authors.initials: L
authors.lastname: Fotis
authors.forename: Kevin
authors.initials: K
authors.lastname: Baszis
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001170:Arthritis, Infectious / Q000209:etiology; D001171:Arthritis, Juvenile / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000209:etiology; D004535:Ehlers-Danlos Syndrome / Q000209:etiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D009080:Mucocutaneous Lymph Node Syndrome; D009205:Myocarditis / Q000209:etiology; D012213:Rheumatic Fever / Q000150:complications; D013290:Streptococcal Infections / Q000150:complications
keywords: Acute rheumatic fever; Juvenile dermatomyositis; Kawasaki disease; Marfan syndrome; Neonatal lupus; Poststreptococcal reactive arthritis; Systemic juvenile idiopathic arthritis