title: Effectiveness of serological markers of eosinophil activity in monitoring eosinophilic esophagitis.
abstract: BACKGROUND
  it is necessary to find serological markers accessible in clinical practice to prevent the need to perform repeated endoscopies.
  
  
  OBJECTIVE
  to assess the efficacy of eosinophil activity markers in monitoring eosinophilic esophagitis (EoE).
  
  
  METHODS
  thirty patients were included prospectively, all under dietary treatment -diets excluding 6 foods, and allergy test based diet (skin prick test and specific IgE). The variables assessed were demographic parameters, eosinophil cationic protein (ECP) levels (μg/mL), total IgE (KU/L), peripheral blood eosinophils (PBE) (U/mm³), and the maximum peak of eosinophils/hpf in esophageal biopsies. The variation found between these figures was assessed in line with response to dietary treatment.
  
  
  RESULTS
  thirty patients (66.7% males; mean age 33.43 years) were included in the study, 22 responders and 8 non-responders. Ninety percent presented a personal history of atopy. No significant decrease was detected in serum total IgE and ECP after diet in responder and nonresponders. However, the PBE decreased significantly in responders but not in nonresponders, PBE in responders (pre-diet. 397.27 vs. post-diet 276.81, p = 0.024) and non-responders PBE (pre-diet. 460 vs. post-diet 317.5, p = 0.23).
  
  
  CONCLUSIONS
  serum total IgE and ECP do not act as markers for EoE activity. However PBE may play a role in this regard, bearing in mind that this parameter may be influenced by concomitant atopic conditions.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Rodríguez-Sánchez
authors.forename: Elisa
authors.initials: E
authors.lastname: Gómez-Torrijos
authors.forename: Eva
authors.initials: E
authors.lastname: de-la-Santa-Belda
authors.forename: Bartolomé
authors.initials: B
authors.lastname: López-Viedma
authors.forename: Francisco
authors.initials: F
authors.lastname: Martín-Dávila
authors.forename: John Patrick
authors.initials: JP
authors.lastname: Pilkington-Woll
authors.forename: Paloma
authors.initials: P
authors.lastname: Donado-Palencia
authors.forename: Pilar
authors.initials: P
authors.lastname: Sánchez-Miranda
authors.forename: José
authors.initials: J
authors.lastname: Olmedo-Camacho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016099:Endoscopy, Gastrointestinal; D057765:Eosinophilic Esophagitis / Q000175:diagnosis*; D004804:Eosinophils; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers