title: Impact of cardiac comorbidity on early outcomes after pancreatic resection.
abstract: BACKGROUND
  In patients undergoing pancreatic resection (PR), identification of subgroups at increased risk for postoperative complications can allow focused interventions that may improve outcomes.
  
  
  METHODS
  Patients undergoing PR from 2005-2010 were selected from the American College of Surgeons National Surgical Quality Improvement Program database and categorized as having any history of cardiac disease (angina, congestive heart failure (CHF), myocardial infarction (MI), cardiac stent, or bypass) or as having acute cardiac disease (symptoms of CHF or angina within 30 days or MI within 6 months). These variables were utilized to examine the relationship between cardiac disease and outcomes after PR.
  
  
  RESULTS
  The rate of serious complications and perioperative mortality in patients with any history of cardiac disease vs. those without was 34 vs. 24 % (p < 0.001) and 4.5 vs. 2.0 % (p < 0.001), respectively, and in patients with acute cardiac disease compared to patients without was 37 vs. 25 % (p < 0.001) and 8.6 vs. 2.2 % (p < 0.001), respectively. In multivariate analysis, the two cardiac disease variables remained associated with mortality.
  
  
  CONCLUSIONS
  In patients undergoing PR, cardiac disease is a significant risk factor for adverse outcomes. These observations are critical for meaningful informed consent in patients considering pancreatectomy.
authors.affiliation: Department of Surgery, University of Wisconsin, 600 Highland Avenue, G4/700 CSC, Madison, WI, 53792, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Ronnekleiv-Kelly
authors.forename: David Y
authors.initials: DY
authors.lastname: Greenblatt
authors.forename: Chee Paul
authors.initials: CP
authors.lastname: Lin
authors.forename: Kaitlyn J
authors.initials: KJ
authors.lastname: Kelly
authors.forename: Clifford S
authors.initials: CS
authors.lastname: Cho
authors.forename: Emily R
authors.initials: ER
authors.lastname: Winslow
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Weber
mesh_terms: D000038:Abscess / Q000453:epidemiology; D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D015897:Comorbidity; D003404:Creatinine / Q000097:blood; D004417:Dyspnea / Q000453:epidemiology; D005260:Female; D006304:Health Status; D006331:Heart Diseases / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D034141:Hypoalbuminemia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000401:mortality*; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012140:Respiratory Tract Diseases / Q000453:epidemiology; D012189:Retrospective Studies; D018805:Sepsis / Q000453:epidemiology; D012737:Sex Factors; D013256:Steroids / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology
chemical_list: D013256:Steroids; D003404:Creatinine