title: Intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF: a new synthesis of indole derivatives.
abstract: A new synthesis of indole derivatives has been achieved through intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF. The reaction probably proceeds via an α-amino alkyl radical pathway.
authors.affiliation: Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Wei
authors.forename: Xue-jiao
authors.initials: XJ
authors.lastname: Dong
authors.forename: Shao-zhen
authors.initials: SZ
authors.lastname: Nie
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Chen
authors.forename: Xue-jing
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000588:Amines; D007211:Indoles; D007659:Ketones