title: In brief: the (molecular) pathogenesis of Barrett's oesophagus.
abstract: Barrett's oesophagus is a metaplastic change, such that the normal squamous epithelial lining of the oesophagus is replaced by specialized columnar-lined epithelium. Barrett's oesophagus is clinically significant and has a high health economic impact as it is associated with heightened risk of progression to oesophageal adenocarcinoma. This review discusses the pathogenesis of Barrett's oesophagus with an emphasis on the underlying molecular events.
authors.affiliation: Research Unit Analytical Pathology, Institute of Pathology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Aichler
authors.forename: Axel
authors.initials: A
authors.lastname: Walch
mesh_terms: D001471:Barrett Esophagus / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D060965:Clonal Evolution; D004947:Esophagus / Q000378:metabolism* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008679:Metaplasia; D012307:Risk Factors; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology
keywords: Barrett's oesophagus; oesophagus; pathogenesis