title: Comparison of health status and quality of life of related versus paid unrelated living kidney donors.
abstract: The aim of this cross-sectional study was to assess the health status and quality of life (QOL) of paid unrelated versus related living kidney donors postdonation at Shiraz Transplant Center in Iran. We invited all donors (n = 580, 347 paid unrelated, 233 related) who underwent donor nephrectomy at our center from 2004 to 2010 to participate in a health survey and physical examination. Of 580 donors, 144 consented to participate; participation of paid unrelated donors was significantly lower than related (52/347 vs. 92/233; p < 0.001). Participants underwent a complete physical examination, QOL assessment (using a 36-item short form health survey [SF-36] questionnaire) and laboratory work-up. The paid unrelated donors compared with related donors were younger (34.2 ± 7.2 vs. 40.7 ± 9.7 years, p < 0.001), had shorter time since donation (2.9 ± 1.6 vs. 3.8 ± 2 years, p = 0.004), had higher estimated GFR (72.6 ± 22 vs. 63.8 ± 15.3 mL/min/1.73 m(2), p = 0.006) and had a higher percentage of patients with microalbuminuria (35% vs. 0%, p < 0.001). Additionally, general health and social functioning scores among paid unrelated donors were significantly lower (p < 0.001 and p = 0.02, respectively) than related donors. Other SF-36 scores, although lower in paid unrelated donors, did not reach statistical significance. Iranian paid unrelated donors have lower QOL and higher incidence of microalbuminuria compared with related donors.
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; John C. McDonald Regional Transplant Center, Willis-Knighton Health System, Shreveport, LA; Division of Nephrology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA.
authors.forename: M K
authors.initials: MK
authors.lastname: Fallahzadeh
authors.forename: L
authors.initials: L
authors.lastname: Jafari
authors.forename: J
authors.initials: J
authors.lastname: Roozbeh
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: H
authors.initials: H
authors.lastname: Shokouh-Amiri
authors.forename: S
authors.initials: S
authors.lastname: Behzadi
authors.forename: G A
authors.initials: GA
authors.lastname: Rais-Jalali
authors.forename: M
authors.initials: M
authors.lastname: Salehipour
authors.forename: S A
authors.initials: SA
authors.lastname: Malekhosseini
authors.forename: M M
authors.initials: MM
authors.lastname: Sagheb
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006304:Health Status; D006801:Humans; D007492:Iran; D016030:Kidney Transplantation / Q000191:economics / Q000379:methods* / Q000523:psychology; D019520:Living Donors / Q000523:psychology / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000191:economics; D011507:Proteinuria; D011788:Quality of Life; D051437:Renal Insufficiency / Q000628:therapy
keywords: Glomerular filtration rate; proteinuria; quality of life; renal insufficiency; tissue donors