title: Weight reduction is associated with decreased CRP levels.
abstract: BACKGROUND
  Obesity is very costly for society and weight reduction is important to reduce obesity related diseases. We have evaluated the effect of weight reduction on CRP values to see if high sensitivity CRP could be used to provide persons on life style intervention programs with positive feedback.
  
  
  METHODS
  Study subjects (n = 26) were recruited to a life style intervention program aiming for weight loss among the laboratory staff at Uppsala University Hospital, Sweden. Blood samples for high sensitivity CRP were collected at inclusion and after 4 weeks. Body composition was estimated by measurements performed on an inexpensive bioimpedance analyzer.
  
  
  RESULTS
  CRP reduction was significantly associated with weight reduction after four weeks (p = 0.00005) and eight weeks (p = 0.0002). Data from the bioimpedance analyzer were not useful on an individual level.
  
  
  CONCLUSIONS
  High sensitivity CRP could be used to provide positive feedback in workplace weight reduction programs.
authors.affiliation: Department of Medical Sciences. Section of Clinical Chemistry, Uppsala University, Sweden. anders.larsson@akademiska.se
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Hansson
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Akerfeldt
mesh_terms: D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D008019:Life Style; D057230:Limit of Detection; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D013548:Sweden; D015431:Weight Loss
chemical_list: D002097:C-Reactive Protein