title: Evaluation of antidiabetic and antihyperlipidemic activity of Artemisia indica linn (aeriel parts) in Streptozotocin induced diabetic rats.
abstract: BACKGROUND
  Diabetes mellitus is a major metabolic disorder affecting a huge population all over the world. Artemisia species have been extensively used for the management of diabetes in folkloric medicine. The present study is designed to investigate the antidiabetic and antihyperlipidemic effects of aeriel parts of Artemisia indica.
  
  
  METHODS
  Hydromethanolic crude extracts, chloroform, ethyl acetate and n-butanol fractions of aerial parts of Artemisia indica were tested for their antidiabetic potential in Streptozotocin (STZ) (50mg/kg, i.p.) induced diabetic Sprague-Dawley rats. Blood glucose level, body weight, serum lipid profile and activities of liver enzymes were determined. The extracts were further subjected to preliminary phytochemical analysis.
  
  
  RESULTS
  A daily oral dose of hydromethanolic crude extracts (200 and 400mg/kg b.w.) and chloroform fraction (200mg/kg b.w.) of Artemisia indica for 15 days showed a significant reduction in blood glucose level which was comparable to that of the standard antidiabetic drug, glibenclamide (500 μg/kg, p.o.). Artemisia indica extracts also showed reduction in total cholesterol, triglycerides and low density lipoproteins as well as serum creatinine level, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) in diabetic rats.
  
  
  CONCLUSIONS
  According to the results Artemisia indica possesses hypoglycemic, antihyperlipidemic and valuable effects on liver and renal functions in diabetic rats, which seems to validate its traditional usage.
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Pakistan.
authors.forename: Waqar
authors.initials: W
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Pakistan.
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Pakistan.
authors.forename: Mir Azam
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Department of Chemistry, University of Malakand, Chakdara, Pakistan.
authors.forename: Manzoor
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
authors.forename: Fazal
authors.initials: F
authors.lastname: Subhan
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Pakistan. Electronic address: nasiara.karim@hotmail.com.
authors.forename: Nasiara
authors.initials: N
authors.lastname: Karim
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts
keywords: Artemisia indica; Asteraceae; Glibenclamide; Hypoglycemic; Streptozotocin-induced diabetes