title: Broad intrinsic functional connectivity boundaries of the macaque prefrontal cortex.
abstract: Based upon cytoarchitectonic properties, the primate prefrontal cortex has been partitioned into different subregions that show unique structural connectivity patterns, with ongoing efforts to provide more fine-grained divisions. While meaningful divisions may be found within the sub-millimeter range, the subdivisions exist within an overall hierarchical architecture and at higher levels likely share similar activity patterns and functionality. Here, we used resting-state fMRI in lightly anesthetized macaque monkeys to measure the intrinsic functional connectivity of the prefrontal cortex. At a gross anatomical level, the data driven approach revealed five broad clusters that showed distinct brain-wide functional connectivity. Although each cluster encompasses several cytoarchitectonic subregions, the clusters overlap with the intrinsic structural connectivity of the prefrontal cortex and each cluster may subserve common functions.
authors.affiliation: Robarts Research Institute, University of Western Ontario, London, Ontario, Canada. Electronic address: rhutchison@FAS.Harvard.edu.
authors.forename: R Matthew
authors.initials: RM
authors.lastname: Hutchison
authors.affiliation: Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Research Group Competition and Priority Control in Mind & Brain, Center for Interdisciplinary Research, Bielefeld University, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Everling
mesh_terms: D000818:Animals; D063132:Connectome / Q000379:methods*; D008252:Macaca fascicularis / Q000033:anatomy & histology / Q000502:physiology; D008253:Macaca mulatta / Q000033:anatomy & histology / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology
keywords: Connectivity; Macaque; Parcellation; Prefrontal cortex; Resting-state fMRI