title: The effect of juglone on cholinergic mechanisms in rat brain synaptosomes.
abstract: Juglone 5-hydroxy-1,4-napthoquinone exerts three activities on cortical synaptosomal preparations. It inhibits the release of acetylcholine and is an even more potent inhibitor of high-affinity choline transport into synaptosomes. In addition, as has already been shown by others using brain homogenates, juglone inhibits choline acetyltransferase.
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut.
authors.forename: J R
authors.initials: JR
authors.lastname: Cooper
authors.forename: K
authors.initials: K
authors.lastname: Piros