title: Persistent organic pollutants and diabetes: a review of the epidemiological evidence.
abstract: The prevalence of diabetes and obesity has increased rapidly over the last few decades in both developed and developing countries. While it is intuitively appealing to suggest that lifestyle risk factors such as decreased physical activity and adoption of poor diets can explain much of the increase, the evidence to support this is poor. Given this, there has been an impetus to look more widely than traditional lifestyle and biomedical risk factors, especially those risk factors, which arise from the environment. Since the industrial revolution, there has been an introduction of many chemicals into our environment, which have now become environmental pollutants. There has been growing interest in one key class of environmental pollutants known as persistent organic pollutants (POPs) and their potential role in the development of diabetes. This review will summarise and appraise the current epidemiological evidence relating POPs to diabetes and highlight gaps and flaws in this evidence.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: dianna.magliano@bakeridi.edu.au.
authors.forename: D J
authors.initials: DJ
authors.lastname: Magliano
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
authors.forename: V H Y
authors.initials: VHY
authors.lastname: Loh
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: J L
authors.initials: JL
authors.lastname: Harding
authors.affiliation: Inserm, CESP (Centre of Research for Epidemiology and Population Health), U1018, Lifelong Epidemiology of Obesity, Diabetes and Kidney Diseases Team, 94807 Villejuif, France; UMR-S 1018, University Paris-Sud, 94807 Villejuif, France.
authors.forename: J
authors.initials: J
authors.lastname: Botton
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: J E
authors.initials: JE
authors.lastname: Shaw
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D062665:Epidemiological Monitoring; D005260:Female; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D006540:Herbicides / Q000009:adverse effects; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008099:Liver / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000009:adverse effects; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects; D015995:Prevalence; D011485:Protein Binding / Q000187:drug effects; D012307:Risk Factors
chemical_list: D000395:Air Pollutants, Occupational; D004785:Environmental Pollutants; D051246:Glucose Transport Proteins, Facilitative; D006540:Herbicides; D006843:Hydrocarbons, Chlorinated; D007328:Insulin; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls
keywords: Diabetes; Dioxin; Persistent organic pollutants; Polychlorinated biphenyls