title: Diamidines versus Monoamidines as Anti-Pneumocystis Agents: An in Vivo Study.
abstract: Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, respectively. The most efficient antifungal derivatives, namely N,N'-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a diamidine) and N-(benzamidine-4-yl)-N'-phenylethane-1,2-diamine (compound 7, a monoamidine), exhibited no cytotoxicity and were evaluated in vivo in a rat model. Only the diamidine 6 emerged as a promising hit for further studies.
authors.affiliation: Laboratory of Organic Chemistry, University of Mons-UMONS, B-7000 Mons, Belgium. jean-jacques.vandeneynde@umons.ac.be.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Stanicki
authors.forename: Muriel
authors.initials: M
authors.lastname: Pottier
authors.forename: Nausicaa
authors.initials: N
authors.lastname: Gantois
authors.forename: Claire
authors.initials: C
authors.lastname: Pinçon
authors.forename: Delphine
authors.initials: D
authors.lastname: Forge
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mahieu
authors.forename: Sébastien
authors.initials: S
authors.lastname: Boutry
authors.forename: Jean Jacques Vanden
authors.initials: JJ
authors.lastname: Eynde
authors.forename: Anna
authors.initials: A
authors.lastname: Martinez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Dei-Cas
authors.forename: El-Moukhtar
authors.initials: el-M
authors.lastname: Aliouat