title: Emerging surgical therapies for faecal incontinence.
abstract: Faecal incontinence is a common condition and is associated with considerable morbidity and economic cost. The majority of patients are managed with conservative interventions. However, for those patients with severe or refractory incontinence, surgical treatment might be required. Over the past 20 years, numerous developments have been made in the surgical therapies available to treat such patients. These surgical therapies can be classified as techniques of neuromodulation, neosphincter creation (muscle or artificial) and injection therapy. Techniques of neuromodulation, particularly sacral nerve stimulation, have transformed the management of these patients with a minimally invasive procedure that offers good results and low morbidity. By contrast, neosphincter procedures are characterized by being more invasive and associated with considerable morbidity, although some patients will experience substantial improvements in their continence. Injection of bulking agents into the anal canal can improve symptoms and quality of life in patients with mild-to-moderate incontinence, and the use of autologous myoblasts might be a future therapy. Further research and development is required not only in terms of the devices and procedures, but also to identify which patients are likely to benefit most from such interventions.
authors.affiliation: The John Goligher Department of Colon and Rectal Surgery, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mitchell
authors.affiliation: The John Goligher Department of Colon and Rectal Surgery, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Sagar
mesh_terms: D001676:Biofeedback, Psychology / Q000502:physiology; D003107:Colorectal Surgery / Q000379:methods* / Q000639:trends*; D004599:Electric Stimulation Therapy; D005242:Fecal Incontinence / Q000601:surgery*; D006801:Humans; D008160:Lumbosacral Plexus / Q000502:physiology; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000639:trends; D011788:Quality of Life