title: Recurrent H3.3 alterations in childhood tumors.
abstract: Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.
authors.affiliation: Division of Epigenomics and Cancer Risk Factors at the German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Anders M
authors.initials: AM
authors.lastname: Lindroth
authors.forename: Christoph
authors.initials: C
authors.lastname: Plass
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics*; D002804:Chondroblastoma / Q000235:genetics*; D018212:Giant Cell Tumor of Bone / Q000235:genetics*; D006657:Histones / Q000235:genetics*; D006801:Humans
chemical_list: D006657:Histones