title: Indoor and Outdoor Air Pollution and Lung Cancer in New Hampshire and Vermont.
abstract: Indoor and outdoor air pollution is known to contribute to increased lung cancer incidence. This study is the first to address the contribution of home heating fuel and geographical course particulate matter (PM10) concentrations to lung cancer rates in New Hampshire, U.S. First, Pearson correlation analysis and Geographically weighted regression were used to investigate spatial relationships between outdoor PM10and lung cancer rates. While the aforementioned analyses did not indicate a significant contribution of PM10to lung cancer in the state, there was a trend towards a significant association in the northern and southwestern regions of the state. Second, case-control data were used to estimate the contributions of indoor pollution and second hand smoke to risk of lung cancer with adjustment for confounders. Increased risk was found among those who used wood or coal to heat their homes for more than 10 winters before the age of 18, with a significant increase in risk per winter. Resulting data suggest that further investigation of the relationship between heating-related air pollution levels and lung cancer risk is needed.
authors.affiliation: Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, NH 03756.
authors.forename: Chantel D
authors.initials: CD
authors.lastname: Sloan
authors.forename: Angeline S
authors.initials: AS
authors.lastname: Andrew
authors.forename: Joann F
authors.initials: JF
authors.lastname: Gruber
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Mwenda
authors.forename: Jason H
authors.initials: JH
authors.lastname: Moore
authors.forename: Tracy
authors.initials: T
authors.lastname: Onega
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Karagas
authors.forename: Xun
authors.initials: X
authors.lastname: Shi
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell