title: Development and characterization of niosomal gel for topical delivery of benzoyl peroxide.
abstract: Benzoyl peroxide (BPO) is generally considered as first line treatment against acne. Low water solubility and formation of larger clusters and limited skin permeation upon topical application necessitates the application of high amount of drug for desired action which leads to induction of skin irritation. In the present study, we developed BPO-loaded niosomal formulation to improve its permeation through skin. The niosomes were further loaded in the carbopol gel to improve contact time. The results of the skin permeation study, skin retention study revealed that niosomes can effectively improve the drug permeation through skin. Application of niosomal gel significantly reduced the bacterial load after a treatment of four days. This reduction in bacterial load was further resulted in a significant reduction in the inflammation with minimal skin irritation compared with plain drug and the plain niosomal formulation.
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Gagan
authors.initials: G
authors.lastname: Goyal
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Basant
authors.initials: B
authors.lastname: Malik
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Chauhan
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
keywords: Acne; carbopol gel; niosomes; skin permeation