title: Prognostic role of microRNA-100 in various carcinomas: evidence from six studies.
abstract: Recent studies have shown that microRNAs (miRNA) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for patients with cancers. We performed this meta-analysis to provide a comprehensive evaluation of the role of miRNA-100 expression on the overall survival rate by calculating the pooled hazard ratio (HR) for overall survival (OS), which compared the high and low expression levels of miR-100 in patients of the available studies. Finally, a total of six studies dealing with various carcinomas were involved for this meta-analysis. The results indicated that lower expression of miR-100 in cancerous tissue could significantly predict poorer survival in various carcinomas with the pooled HR of 2.19 (95% CI 1.49-3.24, P = 0.0007). In conclusion, the findings from this present meta-analysis suggest that miR-100 expression is associated with OS in cancer patients and could be a useful clinical prognostic factor for those patients.
authors.affiliation: Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Biqiang
authors.initials: B
authors.lastname: Zheng
authors.forename: Chunmeng
authors.initials: C
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Chunyan
authors.initials: C
authors.lastname: Du
authors.forename: Guangfa
authors.initials: G
authors.lastname: Zhao
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Shi
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality; D011379:Prognosis
chemical_list: C544266:MIRN100 microRNA, human; D035683:MicroRNAs