title: The pathologic basis of recovery.
abstract: More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.
authors.affiliation: Centre for Inherited Cardiovascular Diseases, IRCCS Foundation Policlinico San Matteo, Piazzale Golgi 19, Pavia 27100, Italy.
authors.forename: Nupoor
authors.initials: N
authors.lastname: Narula
authors.forename: Manuela
authors.initials: M
authors.lastname: Agozzino
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gazzoli
authors.forename: Monica
authors.initials: M
authors.lastname: Concardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Pagani
authors.forename: Valentina
authors.initials: V
authors.lastname: Favalli
authors.forename: Takahide
authors.initials: T
authors.lastname: Kodama
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mazzola
authors.forename: Andrea M
authors.initials: AM
authors.lastname: D'Armini
authors.forename: Eloisa
authors.initials: E
authors.lastname: Arbustini
mesh_terms: D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology* / Q000601:surgery; D006353:Heart-Assist Devices; D006801:Humans; D020257:Ventricular Remodeling
keywords: Left ventricular assist device; Reverse remodeling; Unloading left ventricle