title: MicroRNAs and Lipoprotein Metabolism.
abstract: MicroRNAs(miRNAs; miRs) are small, non-protein-coding RNAs that negatively regulate the gene expression. They bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recently, some miRNAs have been shown to be involved in lipid homoeostasis. In particular, miR122 and miR-33 have a significant impact on lipid homeostasis and are potential therapeutic targets for treating lipid disorders and/or atherosclerosis. In this review, we describe the current understanding of the function of miRNAs in lipid homeostasis, with a focus on lipoprotein metabolism.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Horie
authors.forename: Osamu
authors.initials: O
authors.lastname: Baba
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yokode
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
authors.forename: Koh
authors.initials: K
authors.lastname: Ono
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D008074:Lipoproteins; D035683:MicroRNAs