title: Nebulized voriconazole in infections with Scedosporium apiospermum--case report and review of the literature.
abstract: Scedosporium infections are rare complications in immunocompromised patients or patients with chronic pulmonary disease. While Scedosporium prolificans is resistant to most antimycotics, Scedosporium apiospermum is usually sensitive to voriconazole and posaconazole. Pharmacokinetics and efficacy of nebulized voriconazole have been described in a murine model previously. We report for the first time the safe and effective use of nebulized voriconazole for the treatment of severe pulmonary infection with Scedosporium apiospermum in an adolescent with cystic fibrosis.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Eythstrasse 24, 89075 Ulm, Germany. Electronic address: johannes.holle@uniklinik-ulm.de.
authors.forename: J
authors.initials: J
authors.lastname: Holle
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Eythstrasse 24, 89075 Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Leichsenring
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Eythstrasse 24, 89075 Ulm, Germany.
authors.forename: P E
authors.initials: PE
authors.lastname: Meissner
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D009330:Nebulizers and Vaporizers; D021681:Scedosporium / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D065819:Voriconazole / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole
keywords: Antimycotic treatment; Cystic fibrosis; Fungal infections; Scedosporium apiospermum