title: Preparation of microcapsules by complex coacervation of gum Arabic and chitosan.
abstract: Gum Arabic-chitosan microcapsules containing a commercially available blend of triglycerides (Miglyol 812 N) as core phase were synthesized by complex coacervation. This study was conducted to clarify the influence of different parameters on the encapsulation process, i.e. during the emulsion formation steps and during the shell formation, using conductometry, zeta potential, surface and interface tension measurement and Fourier-transform infrared spectroscopy. By carefully analyzing the influencing factors including phase volume ratio, stirring rate and time, pH, reaction time, biopolymer ratio and crosslinking effect, the optimum synthetic conditions were found out. For the emulsion step, the optimum phase volume ratio chosen was 0.10 and an emulsion time of 15 min at 11,000 rpm was selected. The results also indicated that the optimum formation of these complexes appears at a pH value of 3.6 and a weight ratio of chitosan to gum Arabic mixtures of 0.25.
authors.affiliation: Univ Lille Nord de France, F-59000 Lille, France; ENSAIT, GEMTEX, F-59100 Roubaix, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Butstraen
authors.forename: Fabien
authors.initials: F
authors.lastname: Salaün
mesh_terms: D002214:Capsules; D048271:Chitosan / Q000737:chemistry*; D003217:Conductometry; D004339:Drug Compounding; D004655:Emulsions; D006170:Gum Arabic / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D011122:Polyphosphates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014280:Triglycerides / Q000737:chemistry*
chemical_list: D002214:Capsules; D004655:Emulsions; D008823:Micelles; D011122:Polyphosphates; D014280:Triglycerides; C022834:miglyol 812; D006170:Gum Arabic; D048271:Chitosan; C005692:triphosphoric acid
keywords: Chitosan; Complex coacervation; Gum Arabic; Microcapsules; Oil in water emulsion; Tripolyphosphate