title: A FUT2 gene common polymorphism determines resistance to rotavirus A of the P[8] genotype.
abstract: Attachment to carbohydrates of the histo-blood group type of several human Rotavirus strains (RVA) has recently been described. Synthesis of these ligands requires a functional FUT2 enzyme, suggesting that FUT2 null homozygote (ie, nonsecretor) individuals may not be recognized by most human RVA strains. Whereas such individuals represent 20% of the control population, this retrospective study determined that none of 51 patients infected by P[8] rotavirus strains were nonsecretors. The lack of α1,2fucosylated carbohydrate motifs in the gut surface mucosa is thus associated with resistance to symptomatic infection and virus attachment to such motifs is essential to the infection process.
authors.affiliation: Service de Virologie, CHU de Nantes, and UPRES-EA4271, Nantes University.
authors.forename: Berthe-Marie
authors.initials: BM
authors.lastname: Imbert-Marcille
authors.forename: Laure
authors.initials: L
authors.lastname: Barbé
authors.forename: Mathilde
authors.initials: M
authors.lastname: Dupé
authors.forename: Béatrice
authors.initials: B
authors.lastname: Le Moullac-Vaidye
authors.forename: Bernard
authors.initials: B
authors.lastname: Besse
authors.forename: Cécile
authors.initials: C
authors.lastname: Peltier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ruvoën-Clouet
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Pendu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D060467:Disease Resistance / Q000235:genetics; D005243:Feces / Q000821:virology*; D005647:Fucosyltransferases / Q000235:genetics*; D005753:Gastric Mucosa / Q000821:virology; D005759:Gastroenteritis / Q000235:genetics* / Q000821:virology; D005838:Genotype; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000235:genetics* / Q000821:virology; D055815:Young Adult; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase
keywords: FUT2; histo-blood group antigens; ligands; rotavirus; secretor phenotype