title: Biphenyl derivatives from Garcinia schomburgkiana and the cytotoxicity of the isolated compounds.
abstract: Study of the chemical constituents of the stems of Garcinia schomburgkiana Pierre (Guttiferae), collected in Thailand, led to the isolation and identification of five known compounds and two new biphenyl derivatives, schomburgbiphenyl A (1) and B (2). Six phenolic compounds isolated from this plant were screened for their cell growth inhibition activity using several human leukemia cell lines. One compound, oblongifolin C (7), showed significant cytotoxic activity towards Jurkat, NALM6, K562 and HPB-ALL cells.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsui
authors.forename: Eri
authors.initials: E
authors.lastname: Noda
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D019169:Jurkat Cells; D020014:K562 Cells; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; C585676:schomburgbiphenyl A; C585675:schomburgbiphenyl B