title: A Case of Acute Cerebral Aspergillosis Complicating Influenza A/H1N1pdm 2009.
abstract: Invasive aspergillosis is a rare complication in patients with influenza infection. Several cases of invasive pulmonary aspergillosis accompanying influenza infections were reported during the influenza A/H1N1pdm 2009. We encountered a case of acute cerebral aspergillosis in a patient with influenza A/H1N1pdm 2009 infection. A 24-year-old man with uncontrolled diabetes was diagnosed with influenza A/H1N1pdm 2009 infection. Initial evaluation indicated methicillin-sensitive Staphylococcus aureus pneumonia and diabetic ketoacidosis along with influenza. During his hospital course, multiple new rim-enhancing mass lesions not evident in the initial evaluation developed in the fronto-parietal cortical and subcortical white matter and right cerebellum. Pathology and culture results confirmed the presence of Aspergillus fumigatus. Surgical drainage combined with a total of 18 weeks of antifungal therapy resulted in complete resolution of the infection. This case demonstrates that cerebral aspergillosis can present alongside influenza in patients with diabetes or those under intensive care. Clinical suspicion of invasive aspergillosis is required for a definite diagnosis and better prognosis in such cases.
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Kim
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Chang Kyung
authors.initials: CK
authors.lastname: Kang
authors.forename: Kang Il
authors.initials: KI
authors.lastname: Jun
authors.forename: Ji-Hwan
authors.initials: JH
authors.lastname: Bang
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Park
authors.forename: Myoung-Don
authors.initials: MD
authors.lastname: Oh
keywords: Brain abscess; Central nervous system; Diabetes mellitus; Influenza; Invasive aspergillosis