title: Copper ion as a delivery platform for taxanes and taxane complexes.
abstract: A number of delivery agents, such as proteins, liposomes, micelles, and nanoparticles, are utilized for transporting pharmaceutical agents in a physiological environment. This Letter focuses on the use of the copper(II) ion and its potential role as a delivery agent for the taxanes and taxol couple to a malaria drug. Nuclear magnetic resonance (NMR, (1)H, (13)C, (15)N), Mass Spectrometry (LC-MS, MALDI-TOF, FT-ICR) and computational methods are used to examine the structure of the complex. The National Cancer Institute's benchmark 60 cell line panel is used to compare the efficacy of the copper-taxol and copper-taxol-hydroxychloroquin complexes to that of iron-taxol and pure taxol.
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States. Electronic address: tmanning@valdosta.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Manning
authors.affiliation: PAMS Facility, Department of Chemistry, University of Georgia, Athens, GA, United States.
authors.forename: Dennis
authors.initials: D
authors.lastname: Phillips
authors.affiliation: NMR Facility, Department of Chemistry, University of Georgia, Athens, GA, United States.
authors.forename: Greg
authors.initials: G
authors.lastname: Wylie
authors.affiliation: National High Magnetic Field Laboratory, Ion Cyclotron Resonance Facility, Florida State University, Tallahassee, FL 32310-4005, United States.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bythell
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Shannon
authors.initials: S
authors.lastname: Clark
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Ryenne
authors.initials: R
authors.lastname: Ogburn
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Kaitlyn
authors.initials: K
authors.lastname: Ledwitch
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Chad
authors.initials: C
authors.lastname: Collis
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Patterson
authors.affiliation: Department of Chemistry, Valdosta State University, Valdosta, GA 31698, United States.
authors.forename: Landon
authors.initials: L
authors.lastname: Lasseter
mesh_terms: D000962:Antimalarials / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006886:Hydroxychloroquine / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D004337:Drug Carriers; D007477:Ions; D009942:Organometallic Compounds; D043823:Taxoids; D006886:Hydroxychloroquine; D003300:Copper; D017239:Paclitaxel
keywords: Cancer; Cell line; Drug delivery; Hydroxychloroquin; Mass Spec; NMR; Taxane; Taxol