title: Bacteriophage inspired antibiotics discovery against infection involved biofilm.
abstract: Bacterial biofilm profoundly influences the fate of bacteria within and the outcome of related infection, and is closely associated with antibiotics resistance and bacterial persistence. Bacteriophages represent a new promising alternative to combat biofilm-related infection. The interplay between phages and biofilms is complex. Some phages or their components can inhibit the host bacteria biofilm via diverse mechanisms, while other phages can facilitate the host biofilm formation through phage-mediated lysis and extracellular DNA release. In this paper, we summarize the role of bacteriophages in the biofilm formation, and the application of phages to the control of bacterial persisters and infectious biofilms, in particular, the phage-inspired antibiotics discovery.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Fan
authors.forename: Wu
authors.initials: W
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Zheng
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000821:virology*; D018407:Bacterial Physiological Phenomena; D001435:Bacteriophages / Q000502:physiology*; D018441:Biofilms; D055808:Drug Discovery; D014764:Viral Proteins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D014764:Viral Proteins