title: Thrombolysis With Single Bolus Tenecteplase Compared With Streptokinase Infusion in the Treatment of Acute Pulmonary Embolism: A Pilot Study.
abstract: OBJECTIVE
  This study was planned to compare the efficacy of bolus regimens of tenecteplase (TNK) and 24 hours infusion of streptokinase (STK) in acute pulmonary embolism (APE) in a resource-poor setting.
  
  
  METHODS
  In all, 25 patients received injection of TNK, and 75 patients received infusion of STK over 24 hours.
  
  
  RESULTS
  Pulmonary artery systolic pressure and right ventricular function were improved separately and significantly (P = .01) in both the study groups of patients from baseline at 24 hours or at seventh day and was comparable among the TNK and STK groups of patients. Mean duration of stay in intensive care unit was significantly less (2.2 ± 0.8 vs 3.2 ± 1.3 days; P = .04), and bleeding risk was also found to be nonsignificantly less in the TNK group.
  
  
  CONCLUSIONS
  These results suggest that a 24-hour infusion regimen of STK is as effective as bolus TNK in the treatment of patients with APE in countries with limited resources.
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India dr_soumyapatra@rediffmail.com.
authors.forename: Soumya
authors.initials: S
authors.lastname: Patra
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
authors.forename: C M
authors.initials: CM
authors.lastname: Nagesh
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
authors.forename: Babu
authors.initials: B
authors.lastname: Reddy
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Srinivas
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
authors.forename: Navin
authors.initials: N
authors.lastname: Agrawal
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
authors.forename: C N
authors.initials: CN
authors.lastname: Manjunath
authors.affiliation: Department of Cardiac CT, Trinity Jayadeva Cardiac CT, Bangalore, Karnataka, India.
authors.forename: Madhav
authors.initials: M
authors.lastname: Hegde
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011655:Pulmonary Embolism / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage*; D000077785:Tenecteplase; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase
keywords: fibrinolytic therapy; pulmonary embolism; streptokinase; tenecteplase