title: Coexistence of familial Mediterranean fever and rheumatoid arthritis.
abstract: Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis. Although accompanying seronegative spondyloarthropathy has been reported in FMF, coexistence with rheumatoid arthritis (RA) is very rare. This case report describes a Japanese female RA patient who presented with periodic fever. Genetic analysis revealed compound heterozygous mutations in exon 2 and 3 of the MEFV gene (E148Q/G304R/P369S/R408Q). The patient was successfully treated with colchicine with 3-year follow-up.
authors.affiliation: Department of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center , Kubara 2-1001-1, Omura 856-8652 , Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Seigo
authors.initials: S
authors.lastname: Abiru
authors.forename: Osamu
authors.initials: O
authors.lastname: Sasaki
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Miyashita
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.forename: Yuka
authors.initials: Y
authors.lastname: Jiuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D003078:Colchicine / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D000071198:Pyrin; D016896:Treatment Outcome
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine