title: A molecular rotor for measuring viscosity in plasma membranes of live cells.
abstract: Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane.
authors.affiliation: Chemistry Department, Imperial College London, Exhibition Road, South Kensington, SW7 2AZ, UK. m.kuimova@imperial.ac.uk.
authors.forename: Ismael
authors.initials: I
authors.lastname: López-Duarte
authors.forename: Thanh Truc
authors.initials: TT
authors.lastname: Vu
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Izquierdo
authors.forename: James A
authors.initials: JA
authors.lastname: Bull
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kuimova
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry*; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D010051:Ovarian Neoplasms / Q000473:pathology*; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured; D014783:Viscosity
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes