title: Granulomatosis with polyangiitis (Wegener's granulomatosis) diagnosed by transbronchial biopsy from stenotic portion of mainstem bronchus.
abstract: This report concerns a case of granulomatosis with polyangiitis (GPA) (Wegener's granulomatosis (WG)) with bronchus narrowing. Although nasal biopsy had been performed three times, no positive histology for GPA (WG) could be obtained. Flexible bronchoscopy revealed diffuse erythema, edema of the mucosa and stenosis of the right mainstem bronchus. Transbronchial biopsy identified granuloma with giant cells. These findings led to a diagnosis of GPA (WG). This case suggests that biopsy from the bronchus is useful for diagnosis of GPA (WG).
authors.affiliation: Center for Rheumatic Diseases.
authors.forename: Sho
authors.initials: S
authors.lastname: Sendo
authors.forename: Goh
authors.initials: G
authors.lastname: Tsuji
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Umeda
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ichise
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kumagai
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D001706:Biopsy / Q000379:methods*; D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy / Q000379:methods*; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000209:etiology; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
keywords: Granuloma; Granulomatosis with polyangiitis; Stenosis; Transbronchial biopsy