title: Decreased renal function is an independent predictor of severity of coronary artery disease: an application of Gensini score.
abstract: Coronary artery disease (CAD) is the leading cause of death in patients with chronic kidney disease (CKD).Although many studies have shown a higher prevalence of CAD among these patients, the association between the spectrum of renal dysfunction and severity of CAD remains unclear. In this study, we investigate the association between renal function and the severity of CAD. We retrospectively reviewed the medical records of 1,192 patients who underwent elective coronary angiography (CAG). The severity of CAD was evaluated by Gensini score according to the degree of luminal narrowing and location(s) of obstruction in the involved main coronary artery. In all patients, the estimated glomerular filtration rate (eGFR) was independently associated with Gensini score (β=-0.27, P < 0.001) in addition to diabetes mellitus (β=0.07, P = 0.02), hypertension (β=0.12, P < 0.001), low density lipoprotein (LDL)-cholesterol (β=0.08, P = 0.003), and hemoglobin (β=-0.07, P = 0.03) after controlling for other confounding factors. The result of this study demonstrates that decreased renal function is associated not only with the prevalence, but also the severity, of CAD.
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Il Young
authors.initials: IY
authors.lastname: Kim
authors.forename: In Hye
authors.initials: IH
authors.lastname: Hwang
authors.forename: Kyung Nam
authors.initials: KN
authors.lastname: Lee
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Lee
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Lee
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Shin
authors.forename: Harin
authors.initials: H
authors.lastname: Rhee
authors.forename: Byeongyun
authors.initials: B
authors.lastname: Yang
authors.forename: Sang Heon
authors.initials: SH
authors.lastname: Song
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Seong
authors.forename: Ihm Soo
authors.initials: IS
authors.lastname: Kwak
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications*; D003920:Diabetes Mellitus; D005260:Female; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007668:Kidney; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D008078:Cholesterol, LDL; D006454:Hemoglobins
keywords: Coronary Artery Disease; Gensini Score; Glomerular Filtration Rate; Kidney Failure, Chronic