title: A neuroscientific update on monoamine oxidase and its inhibitors.
abstract: The goal of this brief review is to explain the role of monoamine oxidase enzymes in the neurobiology, etiology, and presentation of psychiatric illnesses, primarily major depressive disorder. This article will initially focus on the basic science and function of the monoamine oxidase system and some proposed neuropsychiatric symptoms that may arise if this enzyme system is altered by genetic predisposition. These findings and theories will next be translationally discussed in regard to clinical application pertaining to enzyme inhibition and the treatment of major depressive and other psychiatric disorders.
authors.affiliation: Psychiatry Department, SUNY Upstate Medical University, Syracuse, New York, USA.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Schwartz
mesh_terms: D002490:Central Nervous System / Q000201:enzymology / Q000502:physiology; D003866:Depressive Disorder / Q000188:drug therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics / Q000502:physiology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase