title: Associations between levels of hydroxylated PCBs and PCBs in serum of pregnant women and blood thyroid hormone levels and body size of neonates.
abstract: The purpose of this study was to investigate possible associations between concentrations of hydroxylated PCBs (OH-PCBs) and PCBs in the serum of women in the first trimester of pregnancy and thyroid hormone levels and body size of newborn infants in 79 mother-neonate pairs. We measured 16 OH-PCB isomers and 29 PCB isomers in the serum of Japanese women sampled at 11.1±1.9 weeks of gestation. The concentrations of free thyroxine (fT4) and thyroid stimulating hormone (TSH) were measured in whole blood spots on filter papers sampled from the neonates. Dietary and lifestyle information of the mothers were obtained by self-administered questionnaires. Geometric mean (GM) concentrations of the sum of 16 OH-PCB isomers and of 29 PCB isomers were 1.2×10(2)pg/g wet wt. and 69ng/g lipid wt., respectively, in maternal serum. The GM concentrations of neonatal fT4 and TSH were 2.21ng/dL and 1.37μIU/mL, respectively. Multiple regression analysis was performed using measures of neonatal thyroid hormones as dependent variable and serum levels of OH-PCBs/PCBs and other potential covariates (age, pre-pregnancy weight, smoking status, etc.) as independent variables. The results demonstrated a significant positive association between the concentrations of some OH-PCB isomers and that of neonatal TSH. There were no significant associations between levels of PCBs and neonatal fT4, or between OH-PCBs/PCBs and body size of neonates. We conclude that exposure to/body burden of OH-PCBs, but not PCBs, at environmental levels during the first trimester of pregnancy can affect neonatal thyroid hormone status.
authors.affiliation: Department of Environmental Studies, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8563, Japan. Electronic address: a_hisada@kumamoto-u.ac.jp.
authors.forename: Aya
authors.initials: A
authors.lastname: Hisada
authors.affiliation: Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Shimodaira
authors.affiliation: Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okai
authors.affiliation: Shimadzu Techno-Research, Inc., #1 Nishinokyo-Shimoaicho, Nakagyo-ku, Kyoto 604-8436, Japan.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Shimadzu Techno-Research, Inc., #1 Nishinokyo-Shimoaicho, Nakagyo-ku, Kyoto 604-8436, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takemori
authors.affiliation: Shimadzu Techno-Research, Inc., #1 Nishinokyo-Shimoaicho, Nakagyo-ku, Kyoto 604-8436, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Takasuga
authors.affiliation: Japan Public Health Association, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Koyama
authors.affiliation: Japan Public Health Association, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Watanabe
authors.affiliation: Japan Public Health Association, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Suzuki
authors.affiliation: Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Shirakawa
authors.affiliation: Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Noda
authors.affiliation: Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Komine
authors.affiliation: Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Nagako
authors.initials: N
authors.lastname: Ariki
authors.affiliation: Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.affiliation: Department of Environmental Studies, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8563, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshinaga
mesh_terms: D001724:Birth Weight; D049628:Body Size; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006801:Humans; D006900:Hydroxylation; D007231:Infant, Newborn; D018811:Maternal Exposure; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D011078:Polychlorinated Biphenyls; D013974:Thyroxine
keywords: Birth size; Hydroxylated polychlorinated biphenyls; Neonate; Polychlorinated biphenyls; Pregnant woman; Thyroid hormones