title: Successful treatment of multiple hepatocellular adenomas with percutaneous radiofrequency ablation.
abstract: Hepatocellular adenoma (HCA) is one of the important complications of glycogen storage disease type Ia (GSD-Ia) because it can be transformed into hepatocellular carcinoma. Although surgical resection is a standard treatment of choice for solitary HCA, multiple HCAs in GSD-Ia patients present as therapeutic challenges for curative treatment. Therefore, treatment strategy according to malignant potential is important in management of HCAs in GSD-Ia. The authors present a case of histologically proven multiple HCAs without β-catenin mutations occurred in a GSD-Ia patient treated successfully with percutaneous radiofrequency ablation as a minimally invasive therapy.
authors.affiliation: Sun Young Ahn, Soo Young Park, Young Oh Kweon, Won Young Tak, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 700-721, South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Ahn
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Park
authors.forename: Young Oh
authors.initials: YO
authors.lastname: Kweon
authors.forename: Won Young
authors.initials: WY
authors.lastname: Tak
authors.forename: Han Ik
authors.initials: HI
authors.lastname: Bae
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Cho
mesh_terms: D018248:Adenoma, Liver Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D017115:Catheter Ablation; D005953:Glycogen Storage Disease Type I / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
keywords: Glycogen storage disease; Hepatocellular adenoma; Radiofrequency ablation; β-catenin activation