title: Mechanisms regulating the development of oligodendrocytes and central nervous system myelin.
abstract: Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization that enables rapid and efficient nerve conduction within the central nervous system. The generation of myelin during development involves a finely-tuned pathway of oligodendrocyte precursor specification, proliferation and migration followed by differentiation and the subsequent myelination of appropriate axons. In this review we summarize the molecular mechanisms known to regulate each of these processes, including the extracellular ligands that promote or inhibit development of the oligodendrocyte lineage, the intracellular pathways they signal through and the key transcription factors that mediate their effects. Many of these regulatory mechanisms have recurring roles in regulating several transitions during oligodendrocyte development, highlighting their importance. It is also highly likely that many of these developmental mechanisms will also be involved in myelin repair in human neurological disease.
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Mitew
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia.
authors.forename: C M
authors.initials: CM
authors.lastname: Hay
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Peckham
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Koenning
authors.affiliation: Department of Anatomy and Neuroscience, The University of Melbourne, Australia; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia. Electronic address: emeryb@unimelb.edu.au.
authors.forename: B
authors.initials: B
authors.lastname: Emery
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism / Q000502:physiology*; D009836:Oligodendroglia / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013116:Spinal Cord / Q000254:growth & development* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors
keywords: Olig2; differentiation; myelination; oligodendrocyte; transcription factors