title: The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists.
abstract: Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, USA. fangy2@corning.com.
authors.forename: Huayun
authors.initials: H
authors.lastname: Deng
authors.forename: Ye
authors.initials: Y
authors.lastname: Fang