title: Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.
abstract: Accumulating evidence implicates the relationship between neuroinflammation and pathogenesis in idiopathic Parkinson's disease (iPD). The nose has recently been considered a gate way to the brain which facilitates entry of environmental neurotoxin into the brain. Our study aims to build a PD model by a natural exposure route. In this report, we establish a new endotoxin-based PD model in mice by unilateral intranasal (i.n.) instillation of the lipopolysaccharides (LPS) every other day for 5 months. These mice display a progressive hypokinesia, selective loss of dopaminergic neurons, and reduction in striatal dopamine (DA) content, as well as α-synuclein aggregation in the SN, without systemic inflammatory and immune responses. This new PD model provides a tool for studying the inflammation-mediated chronic pathogenesis and searching for therapeutic intervention in glia-neuron pathway that will slow or halt neurodegeneration in PD.
authors.affiliation: Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China ; Department of Neurology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Wenbo
authors.initials: W
authors.lastname: Yu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wu
authors.forename: Chan
authors.initials: C
authors.lastname: Chen
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Lou
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Baoguo
authors.initials: B
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000187:drug effects* / Q000473:pathology; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology*; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000473:pathology; D009296:Nasal Cavity / Q000187:drug effects; D018034:Olfactory Receptor Neurons / Q000187:drug effects* / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*
chemical_list: D015386:Hazardous Substances; D008070:Lipopolysaccharides; D004298:Dopamine