title: [Effect of postoperative early enteral nutrition on the recovery of humoral immune function in patients with colorectal carcinoma undergoing elective resection].
abstract: OBJECTIVE
  To investigate the effect of postoperative early oral feeding on humoral immune function and clinical outcome in colorectal cancer patients.
  
  
  METHODS
  Seventy patients with colorectal carcinoma requiring elective colorectal resection were prospectively enrolled and randomized into two groups: early oral feeding group(n=35) and conventional oral feeding group(n=35). The patients in early oral feeding group were started on oral feeding within 12 hours after operation, while patients in conventional group were started on oral feeding after the postoperative first passage of flatus. Postoperative parameters of clinic and humeral immune function were compared between two groups.
  
  
  RESULTS
  Sixty-two patients eventually completed the study, including 32 cases in early oral feeding group and 30 cases in conventional oral feeding group. The average time to first passage of flatus[(2±1) d vs. (4±2) d, P<0.01], the first passage of stool [(3.8±1.6) d vs. (6.4±2.5) d, P<0.01], resumption of regular diet [(4±2) d vs. (8.2±2.2) d, P<0.01] and the postoperative hospital stay [(6±1) d vs. (11.7±3.8) d, P<0.01] were significantly shorter in early oral feeding group as compared to conventional oral feeding group. Significantly faster recovery of postoperative humoral immunity was found. Plasma levels of globulin [(24.1±2.4) g/L vs. (22.1±3.3) g/L, P<0.05], immunoglobulin G[(10.8±2.4) g/L vs. (8.7±2.1) g/L, P<0.01] and complement 4 [(0.24±0.09) g/L vs. (0.17±0.05) g/L, P<0.05] on postoperative day 3 were higher in early oral feeding group as compared to conventional oral feeding group.
  
  
  CONCLUSIONS
  Application of postoperative early oral feeding in patients undergoing elective colorectal resection is safe and effective, which can lead to faster recovery of postoperative humoral immune function and bowel function, and shorter postoperative hospital stay.
authors.affiliation: Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. ylh@medmail.com.cn.
authors.forename: Dong-jie
authors.initials: DJ
authors.lastname: Yang
authors.forename: Wei-ling
authors.initials: WL
authors.lastname: He
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Xu
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Peng
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Wu
authors.initials: W
authors.lastname: Song
authors.forename: Chang-hua
authors.initials: CH
authors.lastname: Zhang
authors.forename: Yu-long
authors.initials: YL
authors.lastname: He
mesh_terms: D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery; D003672:Defecation; D017558:Elective Surgical Procedures; D004750:Enteral Nutrition; D006801:Humans; D056724:Immunity, Humoral; D007902:Length of Stay; D011184:Postoperative Period