title: Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise.
abstract: Capsaicin and evodiamine are 2 thermogenic agents recognized for their ability to stimulate the sympathetic nervous system. We hypothesized that both capsaicin and evodiamine would be effective at increasing thermogenesis and lipid oxidation during rest and exercise. In a randomized, cross-over design, 11 men ingested 500 mg of cayenne pepper (1.25 mg capsaicin), 500 mg evodiamine, or placebo at rest following 30 minutes of energy expenditure assessment using open-circuit spirometry. Energy expenditure was assessed again prior to commencing approximately 30 minutes of treadmill exercise at 65% peak oxygen consumption. Energy expenditure was assessed for another 30 minutes of the post-exercise period. Heart rate, blood pressure, core temperature, and venous blood samples were obtained 30 minutes before supplement ingestion, 1 hour after supplement ingestion, immediately post-exercise, and 45 minutes post-exercise. Serum markers of lipid oxidation (glycerol, free fatty acids, glucose, epinephrine, and norepinephrine) were determined spectrophotometrically with enzyme-linked immunosorbent assay. Two-way analyses of variance with repeated measures were performed for each dependent variable (P ≤ .05) with Supplement and Test as main effects. Statistical analyses revealed significant main effects for Test for hemodynamics, energy expenditure, serum catecholamines, and markers of fat oxidation immediately post-exercise (P < .05). No significant interactions between Supplement and Test were noted for any criterion variable (P > .05). These results suggest that acute ingestion of 500 mg of cayenne (1.25 mg capsaicin) or evodiamine is not effective at inducing thermogenesis and increasing fat oxidation at rest or during exercise in men.
authors.affiliation: Department of Health, Human Performance, and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Schwarz
authors.forename: Mike
authors.initials: M
authors.lastname: Spillane
authors.forename: Paul
authors.initials: P
authors.lastname: La Bounty
authors.forename: Peter W
authors.initials: PW
authors.lastname: Grandjean
authors.forename: Brian
authors.initials: B
authors.lastname: Leutholtz
authors.forename: Darryn S
authors.initials: DS
authors.lastname: Willoughby
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002211:Capsaicin / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry; D018592:Cross-Over Studies; D004734:Energy Metabolism / Q000187:drug effects*; D032086:Evodia / Q000737:chemistry; D015444:Exercise / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D005082:Physical Exertion / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D012146:Rest / Q000502:physiology*; D022722:Thermogenesis / Q000187:drug effects; D055815:Young Adult
chemical_list: D010936:Plant Extracts; D011799:Quinazolines; C049639:evodiamine; D002211:Capsaicin
keywords: 45 minutes post-exercise; 45PE; ATP; Capsaicin; Catecholamines; Energy expenditure; Evodiamine; FFA; Fatty acids; GERD; Humans; IPE; PE; PS; REE; RER; TRPV1; Thermogenesis; Triglycerides; VO(2peak); adenosine tri-phosphate; free fatty acids; gastroesophageal reflux disease; immediate post-exercise; peak oxygen consumption; pre-exercise; pre-supplement; respiratory exchange ratio; resting energy expenditure; transient receptor potential channel vanilloid subfamily member 1