title: Fast depth-sensitive fluorescence measurements in turbid media using cone shell configuration.
abstract: Depth-sensitive fluorescence spectroscopy in a two-layered epithelial tissue phantom was demonstrated using a cone shell configuration implemented by an axicon lens and a fiber assembly including five rings of collection fibers. Each collection fiber ring was located at a different radial distance away from the center, for which fluorescence measurements from all rings showed a larger range of sensitivities to the top and bottom layers compared to the previously reported cone shell configuration. Furthermore, multiple fluorescence spectra corresponding to a range of successive targeted depths can be obtained simultaneously, which shortened data acquisition dramatically and eliminated the mechanical moving components required for depth-sensitive optical measurements in the previous setup. This new setup therefore would be preferred in a clinical setting.
authors.forename: Yi Hong
authors.initials: YH
authors.lastname: Ong
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000362:Agar / Q000737:chemistry; D005182:Flavin-Adenine Dinucleotide / Q000737:chemistry; D009391:Nephelometry and Turbidimetry; D019047:Phantoms, Imaging; D011524:Protoporphyrins / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011524:Protoporphyrins; D005182:Flavin-Adenine Dinucleotide; D000362:Agar; C028025:protoporphyrin IX