title: Effect of (+)-catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male Wistar rats.
abstract: Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-catechin hydrate. Plasma non-enzymatic antioxidants viz. alpha-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson's disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh 160 014, India.
authors.forename: Pranav
authors.initials: P
authors.lastname: Mehra
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Garg
authors.forename: Ashwani
authors.initials: A
authors.lastname: Koul
authors.forename: Devi Dayal
authors.initials: DD
authors.lastname: Bansal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D059305:Diet, High-Fat / Q000009:adverse effects*; D019422:Dietary Sucrose / Q000009:adverse effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D019422:Dietary Sucrose; D014867:Water; D002392:Catechin