title: Is Serum Cystatin C a Predictor of Acute Pulmonary Thromboembolism in Patients With Normal Renal Function?
abstract: Early diagnosis is the key point in the management of acute pulmonary thromboembolism (PTE). There are no reports in the literature comparing the serum cystatin C levels in patients with acute PTE and normal volunteers. Therefore, in this study, we analyzed 50 patients with acute PTE and 45 healthy volunteers with normal renal function. The serum cystatin C level was significantly higher in the PTE group than in the non-PTE group (1.08 mg/dL [interquantile range (IQR) 0.79-1.56] and 0.85 mg/dL [IQR 0.77-1.03], respectively, P = .017). When determining the presence of PTE, the highest value of sensitivity and specificity was set at a cutoff value of 1.15 mg/dL with 93.3% specificity, 46.0% sensitivity, 88.5% positive predictive value, and 60.9% negative predictive value. In the multivariate model, cystatin C was significantly associated with the presence of PTE (odds ratio: 12.34, 95% CI 2.64-57.75). In conclusion, cystatin C may be an indicator of acute PTE in patients with normal renal function.
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey drnuritutar@gmail.com.
authors.forename: Nuri
authors.initials: N
authors.lastname: Tutar
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: N Aleyna
authors.initials: NA
authors.lastname: Kemik
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Insu
authors.initials: I
authors.lastname: Yılmaz
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Büyükoğlan
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Medeniyet University, İstanbul, Turkey.
authors.forename: Asiye
authors.initials: A
authors.lastname: Kanbay
authors.affiliation: Department of Cardiology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Fatma Sema
authors.initials: FS
authors.lastname: Oyak
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Inci
authors.initials: I
authors.lastname: Gülmez
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Demir
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011655:Pulmonary Embolism / Q000097:blood* / Q000503:physiopathology*
chemical_list: D055316:Cystatin C
keywords: cystatin C; diagnosis; pulmonary embolism