title: Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.
abstract: Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
authors.affiliation: Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Smith
authors.affiliation: Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA.
authors.forename: O K
authors.initials: OK
authors.lastname: Rønnekleiv
authors.affiliation: Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA. Electronic address: kellym@ohsu.edu.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kelly
mesh_terms: D054369:Agouti-Related Protein / Q000378:metabolism; D000818:Animals; D001833:Body Temperature Regulation; D004435:Eating; D004734:Energy Metabolism; D004958:Estradiol / Q000378:metabolism* / Q000494:pharmacology; D047628:Estrogen Receptor alpha / Q000378:metabolism; D025461:Feedback, Physiological; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism; D011333:Pro-Opiomelanocortin; D015398:Signal Transduction
chemical_list: D054369:Agouti-Related Protein; D047628:Estrogen Receptor alpha; D009478:Neuropeptide Y; D004958:Estradiol; D011333:Pro-Opiomelanocortin; D043802:GTP-Binding Protein alpha Subunits, Gq-G11
keywords: 17β-Estradiol; Energy homeostasis; NPY/AgRP; POMC