title: Lipid profiles and inflammatory markers after periodontal treatment in children with congenital heart disease and at risk for atherosclerosis.
abstract: Due to the biological associations between periodontal and cardiovascular diseases, as well as the fact that atherosclerosis begins in childhood, behavior based on oral health care and metabolic control from an early age is essential for patients with cardiovascular disease. The aim of this research was to examine the effect of full-mouth scaling and root planing on the reduction of periodontal disease in children with congenital heart disease. In this study, treatments were related to clinical periodontal parameters and also to blood ones, such as lipid profile and inflammatory markers. The patients were divided into two groups: group 1 (n=17), scaling and root planing; and group 2 (n=16), full-mouth scaling and root planing. The results showed a significant improvement in clinical periodontal parameters (P<0.05) in both groups. Considering lipid parameters, total cholesterol, triglycerides, and very-low-density lipoprotein parameters showed significant improvement (P<0.05). There was also an improvement in C-reactive protein (ultrasensitive) in the group treated with scaling and root planing (P<0.05). Fibrinogen and interleukin-6 parameters improved (P<0.05) in both groups. We suggest that both periodontal treatments were effective in children with congenital heart disease, though neither demonstrated superiority.
authors.affiliation: Department of Biosciences and Health, Western Paraná State University (UNIOESTE), Cascavel, Paraná, Brazil.
authors.forename: Adriana Chassot
authors.initials: AC
authors.lastname: Bresolin
authors.forename: Mariana Menegassi
authors.initials: MM
authors.lastname: Pronsatti
authors.forename: Larissa Nicole
authors.initials: LN
authors.lastname: Pasqualotto
authors.forename: Patricia Oehlmeyer
authors.initials: PO
authors.lastname: Nassar
authors.forename: Alex Sandro
authors.initials: AS
authors.lastname: Jorge
authors.forename: Edson Antonio Alves
authors.initials: EA
authors.lastname: da Silva
authors.forename: Carlos Augusto
authors.initials: CA
authors.lastname: Nassar
mesh_terms: D000367:Age Factors; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D002648:Child; D012534:Dental Scaling; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D010510:Periodontal Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016745:Root Planing; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids
keywords: children; congenital; heart defects; inflammation mediators; lipid metabolism; periodontal disease