title: Prevalence of dyslipidaemia in patients with renal cell carcinoma: a case-control study in China.
abstract: OBJECTIVE
  To examine the prevalence of dyslipidaemia in patients with renal cell carcinoma (RCC) in a Chinese population.
  
  
  METHODS
  In all, 550 histologically confirmed RCC cases and 570 controls, matched for age and sex were included. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were assessed before treatment using standard techniques. The lipid profiles were defined as 'normal', 'borderline high', 'high' and 'low' according to Chinese Guidelines on Adult Dyslipidaemia. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression in both unadjusted and adjusted models.
  
  
  RESULTS
  Abnormal LDL elevation was common in RCC cases compared with controls (P < 0.001). Results for total cholesterol, triglyceride and HDL levels between groups were insignificant. The OR for RCC for high levels of LDL (≥160 mg/dL) compared with those with a normal LDL profile was 4.675 (95% CI 1.900-11.500). After adjustment for age, gender, body mass index, smoking status, hypertension, diabetes, total cholesterol and triglyceride, the coexistence of high levels of LDL and RCC was large and statistically significant (OR 8.955, 95% CI 3.371-23.786). There was a significant coexistence of RCC for participants with high LDL levels when subgroups of cases with clear cell subtypes and advanced T stages were compared with controls.
  
  
  CONCLUSIONS
  Abnormal LDL elevation was prevalent in Chinese patients with RCC. The results remain to be evaluated in prospective cohorts.
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Cheng-Yuan
authors.initials: CY
authors.lastname: Gu
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Sun
authors.forename: Ding-Wei
authors.initials: DW
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications*; D016022:Case-Control Studies; D002681:China; D050171:Dyslipidemias / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies
keywords: dyslipidaemia; epidemiology; low-density lipoprotein; renal cell carcinoma