title: Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children.
abstract: Kawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A (GRIN3A) in KD, we investigated genetic variations in GRIN3A in a Taiwanese cohort of 262 KD patients (76 with and 186 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between clinical characteristics and GRIN3A genetic variations in KD. According to univariate regression analysis, CAA formation in KD was significantly associated with fever duration (p < 0.0001), first Intravenous immunoglobulin (IVIG) used (days after day one of fever) (p < 0.0001), and the GRIN3A (rs7849782) genetic variant (p < 0.001). KD patients with GG+GC genotype showed a lower rate of developing CAA (GG+GC genotype: odds ratio = 0.26; 95% CI = 0.14-0.46). Significant associations were identified between KD with CAA complication and the GRIN3A (rs7849782) genetic variant by using multivariate regression analysis. Specifically, significant correlations were observed between KD with CAA complications and the presence of GG+GC genotypes for the GRIN3A rs7849782 single-nucleotide polymorphism (full model: odds ratio = 0.25; 95% CI = 0.14-0.46). Our results suggest that a polymorphism of the GRIN3A gene may play a role in KD pathogenesis.
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan ; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Lin
authors.forename: Jeng-Sheng
authors.initials: JS
authors.lastname: Chang
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Chien-Hui
authors.initials: CH
authors.lastname: Hung
authors.forename: Ting-Hsu
authors.initials: TH
authors.lastname: Lin
authors.forename: Shao-Mei
authors.initials: SM
authors.lastname: Huang
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
authors.forename: Chia-Yen
authors.initials: CY
authors.lastname: Chen
authors.forename: Chiu-Chu
authors.initials: CC
authors.lastname: Liao
authors.forename: Cheng-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Chih-Ho
authors.initials: CH
authors.lastname: Lai
authors.forename: Ni
authors.initials: N
authors.lastname: Tien
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Lan
authors.forename: Mao-Wang
authors.initials: MW
authors.lastname: Ho
authors.forename: Wen-Kuei
authors.initials: WK
authors.lastname: Chien
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Yu-Chuen
authors.initials: YC
authors.lastname: Huang
authors.forename: Hsinyi
authors.initials: H
authors.lastname: Tsang
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chang
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D044466:Asian People / Q000235:genetics; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D015810:Linkage Disequilibrium; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D013624:Taiwan
chemical_list: C548929:GRIN3A protein, human; D016194:Receptors, N-Methyl-D-Aspartate