title: A combination of topical and systemic carbonic anhydrase in the treatment of chromosome X-linked retinoschisis.
abstract: METHODS
  A 17 year-old male patient, who since 2000 has referred to a progressive bilateral decrease in visual acuity. A "bicycle wheel" macula pattern was observed in his retina. The electroretinogram showed a decrease in the b-wave amplitude. The visual evoked potentials were normal. Optical coherence tomography showed bilateral macular edema. All this supported the diagnosis of X-linked retinoschisis.
  
  
  CONCLUSIONS
  Genetic counseling was given and the pattern of X-linked inheritance was explained. A significant improvement of the macular thickness was observed after treatment with topical dorzolamide and oral acetazolamide.
authors.affiliation: Sección Retina/Oftalmología, Hospital Universitario de Canarias, Tenerife, España. Electronic address: procha975@yahoo.es.
authors.forename: P
authors.initials: P
authors.lastname: Rocha Cabrera
authors.affiliation: Sección Retina/Oftalmología, Hospital Universitario de Canarias, Tenerife, España.
authors.forename: A C
authors.initials: AC
authors.lastname: Pareja Ríos
authors.affiliation: Sección Retina/Oftalmología, Hospital Universitario de Canarias, Tenerife, España.
authors.forename: L
authors.initials: L
authors.lastname: Cordovés Dorta
authors.affiliation: Sección Retina/Oftalmología, Hospital Universitario de Canarias, Tenerife, España.
authors.forename: C
authors.initials: C
authors.lastname: Mantolán Sarmiento
authors.affiliation: Sección Retina/Oftalmología, Hospital Universitario de Canarias, Tenerife, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Serrano García
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage*; D000287:Administration, Topical; D000293:Adolescent; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D041441:Retinoschisis / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide; D000086:Acetazolamide
keywords: Chromosome; Cromosoma; Dorzolamida; Dorzolamide; Ligada-X; Retinoschisis; Retinosquisis; X-linked