title: Central nervous system stimulant actions of Alpinia galanga (L.) rhizome: a preliminary study.
abstract: Methanolic and ethyl acetate extract of A. galanga showed significant central nervous system (CNS) stimulant activity in mice using actophotometer and rotarod test. CNS stimulation at a dose of 500 mg/kg was comparable with standard drugs caffeine and amphetamine derivative modalart. The extracts did not shown any depressant effect in forced swim or tail suspension tests. It can be concluded that A. galanga rhizome may have stimulant activity in mice and the active constituents responsible for this effect is present both in crude methanolic extract as well as in ethyl acetate fraction of methanolic extract of this plant species.
authors.affiliation: Gupta College of Technological Sciences, College of Pharmacy, Ashram More, G.T. Road, Asansol 713 30, India.
authors.forename: Sayan
authors.initials: S
authors.lastname: Saha
authors.forename: Sugato
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D032429:Alpinia / Q000737:chemistry; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry
chemical_list: D000697:Central Nervous System Stimulants; D010936:Plant Extracts