title: Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation.
abstract: Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. hohno@pharm.kyoto-u.ac.jp nfujii@pharm.kyoto-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Iwata
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Inuki
authors.forename: Shinya
authors.initials: S
authors.lastname: Oishi
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry
chemical_list: D007211:Indoles; D013141:Spiro Compounds; D010165:Palladium; D009584:Nitrogen