title: Age-related vascular differences among patients suffering from multiple sclerosis.
abstract: The aim of our study was to analyze morphological and functional aspects of cerebral veins by means of ecocolor-Doppler in young (i.e., ≤ 30 years old) and older (i.e., >30 years old) patients suffering from multiple sclerosis. 552 multiple sclerosis patients were evaluated by means of a dedicated Echo-Color-Doppler support (MyLab Vinco echocolor Doppler System, Esaote), in both supine and sitting positions. 458 (83%) showed alterations in their morphological and functional structures of cerebral veins and were divided in two different groups: 1) ≤ 30 (110 patients) and 2) >30 years old (348 patients). Young patients showed a statistically significant higher number of both hemodynamically (44% vs. 35%, p<0.01) and non-hemodynamically (51% vs. 45%, p<0.05) significant stenosis in the internal jugular veins as compared to older patients. A lower percentage of young patients showed blocked outflow in the cervical veins (50% vs. 65%, p<0.01) as compared to older ones. Patients >30 years old outlined a significantly higher disability degree (Expanded Disability Status Scale score: 5 vs. 3, p<0.01) as well as higher disease duration (12 vs. 5 months, p<0.01) than younger. No differences could be outlined about multiple sclerosis clinical form of the disease. It was evidenced that young and adult groups are different kind of patients, the former showing much more cerebral veins stenosis and blocked flow in internal jugular veins and vertebral veins than the latter. Duration of disease could explain such differences: the higher the diseases duration, the higher the degree of vascular alterations and, therefore, the disability degree. This could be due to the complex venous hemodynamic impairments induced by alterations in vascular walls: the blocked or difficult blood flow through stenosis could increase the hydrostatic pressure in the skull and this could induce damages to cerebral cells leading to the genesis of more advanced morphological abnormalities. Furthermore, the vessels' alterations could impair venous endothelial functions which could turn in a possible alteration of the controls of cerebral vein return which could worsen the cerebral vascular outflow. It may be possible that early clinical, pharmacological and/or invasive vascular interventions could exert a possible role in the natural history of multiple sclerosis. Nevertheless, further trials are needed in order to confirm such considerations.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ciciarello
authors.forename: Sandro
authors.initials: S
authors.lastname: Mandolesi
authors.forename: Aldo Innocente
authors.initials: AI
authors.lastname: Galeandro
authors.forename: Azzurra
authors.initials: A
authors.lastname: Marceca
authors.forename: Michele
authors.initials: M
authors.lastname: Rossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.forename: Michele
authors.initials: M
authors.lastname: Gesualdo
authors.forename: Francesca
authors.initials: F
authors.lastname: Cortese
authors.forename: Annapaola
authors.initials: A
authors.lastname: Zito
authors.forename: Francesco
authors.initials: F
authors.lastname: Federico
authors.forename: Paolo
authors.initials: P
authors.lastname: Livrea
authors.forename: Maria
authors.initials: M
authors.lastname: Trojano
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
authors.affiliation: Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, piazza G. Cesare, 11, 70124 - Bari, Italy. marcomatteo.ciccone@uniba.it.
authors.forename: Marco Matteo
authors.initials: MM
authors.lastname: Ciccone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000704:Analysis of Variance; D002550:Cerebral Veins / Q000000981:diagnostic imaging / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D009460:Neurologic Examination; D017585:Ultrasonography, Doppler, Transcranial; D014652:Vascular Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D055815:Young Adult