title: Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions - when, where and how to use: what does the evidence show?
abstract: Infections of contaminated or colonised acute or chronic wounds remain a grave risk for patients even today. Despite modern surgical debridement concepts and antibiotics, a great need exists for new therapies in wound management. Since the late 1990s, advantageous effects of negative pressure wound therapy (NPWT) have been combined with local antiseptic wound cleansing in the development of NPWT with instillation (NPWTi). This article summarises the current scientific knowledge on this topic. MEDLINE literature searches were performed on the subject of negative pressure wound and instillation therapy covering publications from the years 1990 to 2013 (36 peer-reviewed citations) and regarding randomised controlled trials (RCTs) covering wound care with bone involvement (27 publications) or soft-tissue wounds without bone participation (11 publications) from 2005 to 2012. The use of NPWTi in the therapy of infected wounds appears to be not yet widespread, and literature is poor and inhomogeneous. However, some reports indicate an outstanding benefit of NPWTi for patients, using antiseptics such as polyhexanide (concentration 0·005-0·04%) and acetic acid (concentration 0·25-1%) in acute and chronic infected wounds and povidone-iodine (10% solution) as prophylaxis in contaminated wounds with potential viral infection. Soaking times are recommended to be 20 minutes each, using cycle frequencies of four to eight cycles per day. Additionally, the prophylactic use of NPWTi with these substances can be recommended in contaminated wounds that cannot be closed primarily with surgical means. Although first recommendations may be given currently, there is a great need for RCTs and multicentre studies to define evidence-based guidelines for an easier approach to reach the decision on how to use NPWTi.
authors.affiliation: Department of Traumatology and Orthopedics, Septic and Plastic Surgery, Bundeswehrkrankenhaus Berlin, Berlin, Germany.
authors.forename: David A
authors.initials: DA
authors.lastname: Back
authors.forename: Catharina
authors.initials: C
authors.lastname: Scheuermann-Poley
authors.forename: Christian
authors.initials: C
authors.lastname: Willy
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001645:Biguanides / Q000008:administration & dosage; D003428:Cross Infection / Q000517:prevention & control; D019317:Evidence-Based Medicine; D006801:Humans; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D011206:Povidone-Iodine / Q000008:administration & dosage; D013530:Surgical Wound Infection / Q000517:prevention & control; D007507:Therapeutic Irrigation; D014946:Wound Infection / Q000628:therapy*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D001645:Biguanides; C031233:polihexanide; D011206:Povidone-Iodine; D019342:Acetic Acid
keywords: Antiseptics; Contamination; Instillation; Negative pressure wound therapy; Vacuum-assisted closure