title: Diethylstilboestrol for the treatment of prostate cancer: past, present and future.
abstract: The aim of this review was to discuss the most recent data from current trials of diethylstilboestrol (DES) to identify its present role in advanced prostate cancer treatment as new hormonal therapies emerge. The most relevant clinical studies using DES in castration-refractory prostate cancer (CRPC) were identified from the literature. The safety, efficacy, outcomes and mechanisms of action are summarized. In the age of chemotherapy this review highlights the efficacy of oestrogen therapy in CRPC. The optimal point in the therapeutic pathway at which DES should be prescribed remains to be established.
authors.affiliation: Department of Urology, Stepping Hill Hospital, Stockport NHS Foundation Trust , Stockport , UK.
authors.forename: Rafal
authors.initials: R
authors.lastname: Turo
authors.forename: Michal
authors.initials: M
authors.lastname: Smolski
authors.forename: Rachel
authors.initials: R
authors.lastname: Esler
authors.forename: Magda L
authors.initials: ML
authors.lastname: Kujawa
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Bromage
authors.forename: Neil
authors.initials: N
authors.lastname: Oakley
authors.forename: Adebanji
authors.initials: A
authors.lastname: Adeyoju
authors.forename: Stephen C W
authors.initials: SC
authors.lastname: Brown
authors.forename: Richard
authors.initials: R
authors.lastname: Brough
authors.forename: Andrew
authors.initials: A
authors.lastname: Sinclair
authors.forename: Gerald N
authors.initials: GN
authors.lastname: Collins
mesh_terms: D004054:Diethylstilbestrol / Q000494:pharmacology / Q000627:therapeutic use*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol