title: Autoimmune phenotype in patients with common variable immunodeficiency.
abstract: OBJECTIVE
  Autoimmune disorders occur with a higher incidence in common variable immunodeficiency (CVID) patients than in the general population. To describe the clinical features of the autoimmune phenotype in patients with CVID.
  
  
  METHODS
  The hospital records of all diagnosed CVID patients referred to the Children's Medical Center Hospital in Tehran, Iran between 2000 and 2010 were reviewed. Patients were also classified according to the presence or absence of autoimmune disease.
  
  
  RESULTS
  Of 52 patients studied, 26.9% (n=14) had shown at least 1 autoimmune manifestation during the study period. Autoimmune cytopenias and juvenile rheumatoid arthritis were the most common form of autoimmunity in our series. Autoimmunity was significantly associated with polyclonal lymphocytic infiltrative disorders (P = .017), increased serum Immunoglobulin (Ig) M levels (P < .001), decreased IgE values (P = .04) and diminished switched memory B-cell count (P < .001).
  
  
  CONCLUSIONS
  Because autoimmunity is one of the first manifestations in CVID, humoral immune system tests should be considered in autoimmune patients with a history of recurrent infection. The presence of polyclonal lymphocytic infiltrative disorders and decreased switched memory B-cells may predispose CVID patients to autoimmunity.
authors.affiliation: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Abolhassani
authors.forename: D
authors.initials: D
authors.lastname: Amirkashani
authors.forename: N
authors.initials: N
authors.lastname: Parvaneh
authors.forename: P
authors.initials: P
authors.lastname: Mohammadinejad
authors.forename: B
authors.initials: B
authors.lastname: Gharib
authors.forename: S
authors.initials: S
authors.lastname: Shahinpour
authors.forename: A
authors.initials: A
authors.lastname: Hirbod-Mobarakeh
authors.forename: M
authors.initials: M
authors.lastname: Mirghorbani
authors.forename: M
authors.initials: M
authors.lastname: Movahedi
authors.forename: M
authors.initials: M
authors.lastname: Gharagozlou
authors.forename: N
authors.initials: N
authors.lastname: Rezaei
authors.forename: A
authors.initials: A
authors.lastname: Aghamohammadi
mesh_terms: D000293:Adolescent; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D010641:Phenotype; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D007136:Immunoglobulins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination