title: Occupational exposure to ionizing radiation and risk of breast cancer in Western Australia.
abstract: OBJECTIVE
  To evaluate current breast cancer risk due to occupational exposure to ionizing radiation.
  
  
  METHODS
  We analyzed data from the Western Australian population-based Breast Cancer Employment and Environment Study. The Breast Cancer Employment and Environment Study included 1205 cases with incident breast cancer during 2009-2011 and 1789 controls. Age-adjusted odds ratios (ORs) were estimated with logistic regression models.
  
  
  RESULTS
  There was a weak, not statistically significant association between breast cancer and occupational exposure to ionizing radiation (OR = 1.16; 95% confidence interval, 0.86 to 1.57). The risk of human epidermal growth factor receptor 2-positive breast cancer with occupational exposure to ionizing radiation in women who were premenopausal at the time of interview was higher (OR = 2.57; 95% confidence interval, 1.09 to 6.03).
  
  
  CONCLUSIONS
  This study suggests that the risk of breast cancer is low at current levels of occupational exposure to ionizing radiation, although the risk of human epidermal growth factor receptor 2-positive cancer may be a concern.
authors.affiliation: From the Western Australian Institute for Medical Research (Ms Buitenhuis and Drs Fritschi, Thomson, and Peters) and School of Population Health (Dr Heyworth), University of Western Australia, Perth, Western Australia, Australia; Division of Human Nutrition (Ms Buitenhuis), Wageningen University, Wageningen, the Netherlands; and Department of Epidemiology and Preventive Medicine (Dr Glass), Monash University, Melbourne, Victoria, Australia.
authors.forename: Wenny
authors.initials: W
authors.lastname: Buitenhuis
authors.forename: Lin
authors.initials: L
authors.lastname: Fritschi
authors.forename: Allyson
authors.initials: A
authors.lastname: Thomson
authors.forename: Deborah
authors.initials: D
authors.lastname: Glass
authors.forename: Jane
authors.initials: J
authors.lastname: Heyworth
authors.forename: Susan
authors.initials: S
authors.lastname: Peters
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001359:Aviation; D001943:Breast Neoplasms / Q000737:chemistry / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D019981:Health Care Sector; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D017697:Premenopause; D011839:Radiation, Ionizing; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D018570:Risk Assessment; D014904:Western Australia / Q000453:epidemiology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases