title: Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke.
abstract: The role of interleukin-6 (IL-6) as a risk factor for developing depressive symptoms, neuropsychological impairment, and related functional and neurological symptom severity during the acute phase of ischemic stroke is still underexplored. Here, the authors assessed this issue, in 48 patients without significant clinical history for major medical illnesses or other factors that promote inflammation, 72 hours after a first-ever acute ischemic stroke. In the acute phase of ischemic stroke, increased IL-6 plays a key role in the onset of depressive disorders, apathy/amotivation, somatic symptoms of depression, and neurological/functional symptoms, resulting in higher disability and poor outcome of stroke patients.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Spalletta
authors.forename: Luca
authors.initials: L
authors.lastname: Cravello
authors.forename: Francesca
authors.initials: F
authors.lastname: Imperiale
authors.forename: Francesca
authors.initials: F
authors.lastname: Salani
authors.forename: Paola
authors.initials: P
authors.lastname: Bossù
authors.forename: Livio
authors.initials: L
authors.lastname: Picchetto
authors.forename: Marina
authors.initials: M
authors.lastname: Cao
authors.forename: Maurizia
authors.initials: M
authors.lastname: Rasura
authors.forename: Floriana
authors.initials: F
authors.lastname: Pazzelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Orzi
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Robert G
authors.initials: RG
authors.lastname: Robinson
authors.forename: Claudia
authors.initials: C
authors.lastname: Cacciari
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000523:psychology; D003863:Depression / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000523:psychology*; D063189:Symptom Assessment
chemical_list: D015415:Biomarkers; D015850:Interleukin-6