title: Uptake and turnover of(65)Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions.
abstract: After a single injection,(65)Zn is slowly taken up by the brain of the rat to a maximum after 7 d, followed by a turnover phase, with a half-time of about 3 wk. In the brain of rats on a zinc-deficient diet, the(65)Zn content in the brain continued to increase up to 30 d after the injection.The uptake and turnover phases in six different subcellular fractions of the brain showed a pattern similar to that of the whole brain in both the control and zinc-deficient rats. There was no internal redistribution of(65)Zn in the brain under conditions of progressive zinc deficiency.The results are discussed in a model for zinc homeostasis in the brain.
authors.affiliation: Department of Radiochemistry, Interuniversity Reactor Institute, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Wensink
authors.forename: C H
authors.initials: CH
authors.lastname: Paays
authors.forename: C J
authors.initials: CJ
authors.lastname: van den Hamer