title: Significant associations between X-ray repair cross-complementing group 3 genetic polymorphisms and thyroid cancer risk.
abstract: Polymorphisms in X-ray cross-complementing group 3 (XRCC3) are proposed to be associated with cancer susceptibility, but previous studies on the associations between XRCC3 polymorphisms and thyroid cancer are controversial. We performed a systemic review and meta-analysis to investigate the associations of XRCC3 polymorphisms with thyroid cancer risk. We used odds ratio (OR) with 95 % confidence interval (95%CI) to assess the associations. For XRCC3 C241T polymorphism, meta-analysis of total eligible studies showed that there was no association between XRCC3 C241T polymorphism and thyroid cancer risk, but subgroup analysis in Caucasians showed that there was a significant association between XRCC3 C241T polymorphism and thyroid cancer risk (T versus C: OR = 1.30, 95%CI 1.05-1.62, P = 0.01; TT versus CC: OR = 1.74, 95%CI 1.13-2.70, P = 0.01; TT versus
  OR = 1.74, 95%CI 1.16-2.60, P = 0.007). For XRCC3 A17893G polymorphism, meta-analysis of total eligible studies showed that there was an obvious association between XRCC3 A17893G polymorphism and thyroid cancer risk (GG versus AA/AG: OR = 0.57, 95%CI 0.35-0.93, P = 0.02), but subgroup analysis by ethnicity only identify the significant association in Asians. In summary, the meta-analysis suggests that there are significant associations of XRCC3 polymorphisms with thyroid cancer risk. Besides, more studies with large sample sizes are needed to further assess the associations above.
authors.affiliation: Departments of Endocrinology, the Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Yu
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Zheng-Ju
authors.initials: ZJ
authors.lastname: Fu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Yan
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Zhao
authors.forename: Yan-Gang
authors.initials: YG
authors.lastname: Wang
authors.forename: Jianming
authors.initials: J
authors.lastname: Cai
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3