title: Metal-free, acid-promoted synthesis of imidazole derivatives via a multicomponent reaction.
abstract: An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.
authors.affiliation: Departments of Medicinal and Applied Chemistry, Biotechnology, and Pharmacy, Kaohsiung Medical University , Kaohsiung, Taiwan.
authors.forename: Chung-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Pi-Cheng
authors.initials: PC
authors.lastname: Yan
authors.forename: Gopal Chandru
authors.initials: GC
authors.lastname: Senadi
authors.forename: Jeh-Jeng
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000143:Acids / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000143:Acids; D007093:Imidazoles; C029899:imidazole