title: Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving insulin sensitivity.
abstract: METHODS
  Obesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue.
  
  
  RESULTS
  We evaluated the effects of a 1-month curative supplementation with SODB on the adipose tissue of obese hamsters. Animals received either a standard diet or a cafeteria diet for 15 wk. Cafeteria diet induced obesity and related disorders, including insulin resistance and oxidative stress, in the abdominal adipose tissue. After SODB supplementation, the adipose tissue weight was decreased, probably by activating adipocytes lipolysis and thus reducing their size. SODB treatment also resulted in abdominal adipose tissue fibrosis reduction. Finally, SODB administration increased the expression of endogenous antioxidant enzymes and thus reduced oxidative stress and insulin resistance. The improvement of insulin sensitivity observed after SODB treatment could explain adipocyte lipolysis activation and fibrosis reduction.
  
  
  CONCLUSIONS
  These findings demonstrate that a dietary SOD supplementation could be a useful strategy against obesity-related modifications in adipose tissue.
authors.affiliation: Nutrition & Métabolisme, UMR 204 NutriPass - Prévention des Malnutritions et des Pathologies Associées, Université Montpellier Sud de France, Montpellier, France; Bionov Sarl, Avignon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Carillon
authors.forename: Lucie
authors.initials: L
authors.lastname: Knabe
authors.forename: Anne
authors.initials: A
authors.lastname: Montalban
authors.forename: Marie
authors.initials: M
authors.lastname: Stévant
authors.forename: Mayoura
authors.initials: M
authors.lastname: Keophiphath
authors.forename: Dominique
authors.initials: D
authors.lastname: Lacan
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Jean-Max
authors.initials: JM
authors.lastname: Rouanet
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D019662:Cucurbitaceae / Q000201:enzymology*; D019587:Dietary Supplements; D005979:Glutathione Peroxidase / Q000378:metabolism; D007333:Insulin Resistance; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D013481:Superoxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Adipocyte; Endogenous antioxidant defence; Insulin resistance; Lipolysis; Oxidative stress