title: Radiologic patterns of necrosis after proton therapy of skull base tumors.
abstract: BACKGROUND
  Discrimination between radiation necrosis and tumor progression after radiation therapy represents a radiologic challenge. The aim of our investigation is to identify patterns of radiation necrosis on brain magnetic resonance imaging (MRI) and positron emission tomography (PET) with Fluoroethyltyrosin (FET) after proton beam therapy (PBT) for skull base tumors.
  
  
  METHODS
  Five consecutive patients with extra-axial neoplasms were included, presenting a total of eight radiation necrosis lesions (three clival chordomas; two petroclival chondrosarcomas; two women; mean age: 49 ± 18.2 years). Radiation necrosis was defined as the appearance of abnormal enhancement on MRI after PBT decreasing over time, and additional histopathologic confirmation in one patient. MRI and PET imaging were retrospectively analyzed by two experienced radiologists in consensus.
  
  
  RESULTS
  All lesions were localized close to the primary tumor in the field of irradiation. Three patients showed bilateral symmetrical lesions. All lesions showed T2 hyperintensity and T1 hypointensity. Cerebral blood volume (CBV) was reduced in all available studies. None of the lesions showed a restricted diffusion. FET-PET (three patients) showed a higher uptake in four out of five lesions; three of which had a mean tumor-to-background (TBRmean) uptake lower than 1.95 and FET uptake increasing over time and were correctly classified into radiation necrosis.
  
  
  CONCLUSIONS
  Most radiation necroses were in direct continuity with the primary tumor mimicking tumor progression. The most consistent imaging findings for PBT radiation necrosis are low CBV without restricted diffusion and FET-PET TBRmean lower than 1.95 or increasing uptake over time. Bilateral symmetric involvement may be another indicator of radiation necrosis.
  
  
  
  Critères radiologiques de la nécrose après protonthérapie des tumeurs de la base du crâne.
authors.forename: Amine M
authors.initials: AM
authors.lastname: Korchi
authors.forename: Valentina
authors.initials: V
authors.lastname: Garibotto
authors.forename: Karl-Olof
authors.initials: KO
authors.lastname: Lovblad
authors.forename: Sven
authors.initials: S
authors.lastname: Haller
authors.forename: Damien C
authors.initials: DC
authors.lastname: Weber
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D049268:Positron-Emission Tomography; D061766:Proton Therapy; D019291:Skull Base