title: The ameliorating effect of Rosa roxburghii against ethanol-induced psychomotor alterations in rats.
abstract: BACKGROUND
  Ethanol (EtOH) is one of the oldest recreational substances known to man, primarily taken because it induces a sense of well-being (euphoric effects) and relaxation (anxiolytic effects). EtOH use entails various negative consequences. Of particular interest are EtOH-induced psychomotor alterations, because of its immediate manifestation and adverse consequences. Rosa roxburghii (RR), a wild plant of Southwest China, has gained attention on account of its numerous beneficial effects on the immune, nervous, and cardiovascular systems.
  
  
  OBJECTIVE
  In the present study we assessed the effects of Rosa roxburghii (RR) on EtOH-induced psychomotor alterations in rats.
  
  
  METHODS
  Sprague Dawley rats were orally administered distilled water (control group) or ethanol (4 g/kg BW) (EtOH-group) to induce psychomotor alterations. RR extract (25, 50, and 100 mg/kg, p.o.) was administered 30 min before EtOH treatment (RR-group). EtOH-induced psychomotor alterations were evaluated in the open-field, accelerating rotarod, hanging wire, and cold swimming tests. Behavioral evaluation and hematological analysis (EtOH and acetaldehyde concentration) were done at 1, 2, 4 and 8 hours after EtOH administration.
  
  
  RESULTS
  The EtOH group showed psychomotor alterations as compared with the control group. These EtOH-induced psychomotor alterations were directly related to the rise in blood ethanol and acetaldehyde concentrations. Pre-treatment of RR significantly improved EtOH-induced psychomotor alterations on open-field, accelerating rotarod, hanging wire, and cold swimming tests. These improvements in psychomotor performance coincided with the decreased blood ethanol and acetaldehyde levels observed in the RR-treated group.
  
  
  CONCLUSIONS
  These results suggest that RR has ameliorating effects against EtOH-induced psychomotor alterations.
authors.affiliation: Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University , Nowon-gu, Seoul , Republic of Korea and.
authors.forename: Irene Joy I
authors.initials: IJ
authors.lastname: Dela Peña
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Yoon
authors.forename: June Bryan
authors.initials: JB
authors.lastname: de la Peña
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Bitna
authors.initials: B
authors.lastname: Yoon
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Se Hee
authors.initials: SH
authors.lastname: Paek
authors.forename: Yonh Ki
authors.initials: YK
authors.lastname: Seo
authors.forename: Byoung Seok
authors.initials: BS
authors.lastname: Moon
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Cheong
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects*; D051381:Rats; D027826:Rosa; D045442:Rotarod Performance Test
chemical_list: D004365:Drugs, Chinese Herbal; D000431:Ethanol; D000079:Acetaldehyde