title: Catalyst-free dehydrative α-alkylation of ketones with alcohols: green and selective autocatalyzed synthesis of alcohols and ketones.
abstract: Direct dehydrative α-alkylation reactions of ketones with alcohols are now realized under simple, practical, and green conditions without using external catalysts. These catalyst-free autocatalyzed alkylation methods can efficiently afford useful alkylated ketone or alcohol products in a one-pot manner and on a large scale by CC bond formation of the in situ generated intermediates with subsequent controllable and selective Meerwein-Pondorf-Verley-Oppenauer-type redox processes.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035 (China). qing-xu@wzu.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Jianhui
authors.initials: J
authors.lastname: Chen
authors.forename: Haiwen
authors.initials: H
authors.lastname: Tian
authors.forename: Xueqin
authors.initials: X
authors.lastname: Yuan
authors.forename: Shuangyan
authors.initials: S
authors.lastname: Li
authors.forename: Chongkuan
authors.initials: C
authors.lastname: Zhou
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones
keywords: alcohols; aldehydes; autocatalysis; reduction; synthetic methods