title: Diagnosing oesophagitis in children: how discriminative is histology?
abstract: OBJECTIVE
  We set out to evaluate the discriminatory value of currently available histologic criteria in the differential diagnosis of reflux oesophagitis and eosinophilic oesophagitis in children.
  
  
  METHODS
  We evaluated the oesophageal biopsies of 145 children and selected 28 demonstrative cases of clinically confirmed eosinophilic oesophagitis (n = 7), and reflux oesophagitis (n = 11) with a control group with normal histology (n = 10). Histological assessment was performed for the presence of papillary elongation, dilatation of intercellular spaces, basal cell hyperplasia and the number of intraepithelial eosinophils, lymphocytes and neutrophils.
  
  
  RESULTS
  Among 28 children, there were 3 boys and 4 girls in eosinophilic oesophagitis group, 8 boys and 3 girls in reflux group, and 5 boys and 5 girls in normal group. The mean age was 10,4 years. Basal cell hyperplasia was observed in 12 cases while papillary elongation was found in 25, and dilated intercellular spaces were present in 20 cases. Lymphocyte and neutrophil counts were significantly higher in reflux group when compared to eosinophilic oesophagitis and normal group. Eosinophil counts were significantly higher in eosinophilic group.
  
  
  CONCLUSIONS
  Results of the present study suggest that, basal cell hyperplasia, papillary elongation, and dilated intercellular spaces all seem to be markers of oesophagitis regardless of the underlying pathology and etiology, thereby, highlighting their rather nonspecific nature in the differential diagnosis of various types of oesophagitis. The additional information on inflammatory cell counts may help to distinguish reflux oesophagitis from other causes of oesophagitis including EoO.
authors.affiliation: Department of Pathology, Ankara University, Medical School. yykarabulut@yahoo.com.tr
authors.forename: Y Y
authors.initials: YY
authors.lastname: Karabulut
authors.forename: B
authors.initials: B
authors.lastname: Savaş
authors.forename: A
authors.initials: A
authors.lastname: Kansu
authors.forename: N
authors.initials: N
authors.lastname: Kurşun
authors.forename: A
authors.initials: A
authors.lastname: Ensari
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies