title: Influence of Th2 cells on hair cycle/growth after repeated cutaneous application of hapten.
abstract: Exposure to contact allergens in order to produce allergic contact dermatitis (ACD) seems to induce hair cycle/growth, but the mechanism of this remains unclear. In the current study, we investigated this mechanism and found that repeated application of hapten induced production of interleukin (IL)-4 in lymph-node immune cells. In addition, hair growth was induced in mice after the adoptive transfer of T-helper (Th)2 cells that had been purified from mice exposed to repeated cutaneous application of hapten. These findings lead us to speculate that Th2 cells that are repeatedly hapten-sensitized are recruited to hapten-challenged skin areas, and thus stimulate the production of IL-4 in the vicinity of the hair follicles, which influences hair cycle/growth. Our results may provide fundamental insights into the mechanism of contact hypersensitivity-induced hair cycle/growth.
authors.affiliation: Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: A
authors.initials: A
authors.lastname: Ikenouchi-Sugita
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: Y
authors.initials: Y
authors.lastname: Tokura
authors.forename: K
authors.initials: K
authors.lastname: Kabashima
mesh_terms: D000279:Administration, Cutaneous; D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D006241:Haptens / Q000494:pharmacology*; D015847:Interleukin-4 / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D000485:Allergens; D006241:Haptens; D015847:Interleukin-4