title: Choi criteria are superior in evaluating tumor response in patients treated with transarterial radioembolization for hepatocellular carcinoma.
abstract: In this study, Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), Choi and modified Choi criteria were compared to determine which method is optimal for response evaluation in hepatocellular carcinoma (HCC) patients treated with transarterial radioembolization (TARE) with yttrium-90 microspheres. Responses were evaluated by RECIST, mRECIST, Choi and modified Choi criteria in 113 patients with HCC undergoing TARE. Results were compared at 12 weeks after therapy. Kaplan-Meier survival analyses and Cox regression were used to assess differences in time to progression (TTP) and overall survival (OS) between the responders and non-responders defined by each method. The results demonstrated that the responders and non-responders defined by mRECIST and Choi criteria successfully identified patients with a long TTP (400 and 280 days) or short TTP (188 and 166 days) (P=0.004 and 0.002, respectively). Neither RECIST nor modified Choi criteria discriminated between patients who had a short or long clinical benefit. Cox regression analysis revealed that Choi response was a prognostic factor of OS (P=0.004) and was associated with a 53% risk reduction. There was no significant association between survival and RECIST, mRECIST and modified Choi responses. In conclusion, tumor response according to Choi criteria may be helpful to define early HCC patients who benefit from TARE. RECIST, mRECIST and modified Choi appeared inferior.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Essen, Essen D-45122, Germany ; Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Weng
authors.forename: Judith
authors.initials: J
authors.lastname: Ertle
authors.forename: Shaoping
authors.initials: S
authors.lastname: Zheng
authors.forename: Thomas
authors.initials: T
authors.lastname: Lauenstein
authors.forename: Stefan
authors.initials: S
authors.lastname: Mueller
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
authors.forename: Guido
authors.initials: G
authors.lastname: Gerken
authors.forename: Dongliang
authors.initials: D
authors.lastname: Yang
authors.forename: Joerg F
authors.initials: JF
authors.lastname: Schlaak
keywords: Choi criteria; RECIST; hepatocellular carcinoma; mRECIST; transarterial radioembolization; tumor response