title: Development: sketch for a theory of Oct4.
abstract: How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.
authors.affiliation: Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Wagner
authors.affiliation: Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: thomas.zwaka@mssm.edu.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Zwaka
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000166:cytology*; D053263:Gene Regulatory Networks; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*
chemical_list: D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D029867:Xenopus Proteins