title: Statistical mapping of the effect of knee extension on thigh muscle viscoelastic properties using magnetic resonance elastography.
abstract: Skeletal muscle viscoelastic properties reflect muscle microstructure and neuromuscular activation. Elastographic methods, including magnetic resonance elastography, have been used to characterize muscle viscoelastic properties in terms of region of interest (ROI) measurements. The present study extended this approach to create thresholded pixel-by-pixel maps of viscoelastic properties of skeletal muscle during rest and knee extension in eleven subjects. ROI measurements were taken for individual quadricep muscles and the quadriceps region as a whole, and the viscoelastic parameter map pixels were statistically tested at positive false discovery rate q ≤ 0.25. ROI measurements showed significant (p ≤ 0.05) increase in storage modulus (G') and loss modulus (G″), with G″ increasing more than G', in agreement with previous findings. The q-value maps further identified the vastus intermedius as the primary driver of this change, with greater G″/G' increase than surrounding regions. Additionally, a cluster of significant decrease in G″/G' was found in the region of vastus lateralis below the fulcrum point of the lift. Viscoelastic parameter mapping of contracted muscle allows new insight into the relationship between physiology, neuromuscular activation, and human performance.
authors.affiliation: Clinical Research Imaging Centre (CRIC), College of Medicine and Veterinary Medicine, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
authors.forename: Eric
authors.initials: E
authors.lastname: Barnhill
authors.forename: Paul
authors.initials: P
authors.lastname: Kennedy
authors.forename: Steven
authors.initials: S
authors.lastname: Hammer
authors.forename: Edwin J R
authors.initials: EJ
authors.lastname: van Beek
authors.forename: Colin
authors.initials: C
authors.lastname: Brown
authors.forename: Neil
authors.initials: N
authors.lastname: Roberts
mesh_terms: D000328:Adult; D000368:Aged; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007719:Knee Joint / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology; D013223:Statistics as Topic; D013848:Thigh / Q000502:physiology*; D014783:Viscosity; D055815:Young Adult