title: Neurological manifestations in patients with antiphospholipid syndrome.
abstract: BACKGROUND
  Anti-phospholipids syndrome (APS) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. The purpose of the current study was to investigate the frequency of thrombotic and non-thrombotic events in patients with APS.
  
  
  METHODS
  In this retrospective study, 102 definite APS subjects were recruited (2007-2011) at Alzahra Hospital, Isfahan, Iran. The patients were referred to Multiple Sclerosis Clinic with the diagnosis of definite APS according to 2006 Sydney's criteria. Disorders associated with APS such as pregnancy complication, vascular thrombosis and livedo reticularis (LR) were assessed. Neurological signs and symptoms such as cognitive dysfunction were recorded. Data analyses were performed using SPSS software and P < 0.05 were considered to be statistically significant.
  
  
  RESULTS
  Our findings showed that majority of female gender, higher rate of ischemic thrombotic stroke and high miscarriage lied in a large number of APS patients.
  
  
  CONCLUSIONS
  Overall recurrent miscarriage is a common complication among (antiphospholidpid antibody) aPL patients. Furthermore, ischemic stroke is the second common neurological manifestations of APS patients.
authors.affiliation: Professor, Isfahan Multiple Sclerosis and Neuroimmunology Research Center, Isfahan Eye Research Center, Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Etemadifar
authors.forename: Leila
authors.initials: L
authors.lastname: Dehghani
authors.forename: Soheil
authors.initials: S
authors.lastname: Tahani
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Toghianifar
authors.forename: Marzieh
authors.initials: M
authors.lastname: Rahaimi
authors.forename: Nahid
authors.initials: N
authors.lastname: Eskandari
keywords: Antiphospholipid Syndrome; Miscarriage; Neurological Manifestation