title: Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease.
abstract: OBJECTIVE
  There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications.
  
  
  METHODS
  One hundred forty-seven consecutive inpatients with ALD were prospectively recruited. The evaluation of plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications.
  
  
  RESULTS
  Acrp30 and resistin levels were significantly higher in patients with ALD than in controls. Lower leptin levels in females with ALD compared to controls, but no significant differences in leptin concentrations in males, were found. High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy.
  
  
  CONCLUSIONS
  Gender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. Serum Acrp30 level may serve as a potential prognostic indicator for patients with ALD.
authors.affiliation: Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin, 8 Jaczewski Street, 20-954 Lublin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Kasztelan-Szczerbinska
authors.forename: Agata
authors.initials: A
authors.lastname: Surdacka
authors.forename: Maria
authors.initials: M
authors.lastname: Slomka
authors.forename: Jacek
authors.initials: J
authors.lastname: Rolinski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Celinski
authors.forename: Agata
authors.initials: A
authors.lastname: Smolen
authors.forename: Mariusz
authors.initials: M
authors.lastname: Szczerbinski
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D020738:Leptin / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D008107:Liver Diseases / Q000097:blood / Q000150:complications; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D052243:Resistin / Q000097:blood*; D012737:Sex Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin; D052243:Resistin