title: Investigating miscibility and molecular mobility of nifedipine-PVP amorphous solid dispersions using solid-state NMR spectroscopy.
abstract: Solid-state NMR (SSNMR) (1)H T1 and T1ρ relaxation times were used to evaluate the miscibility of amorphous solid dispersions of nifedipine (NIF) and polyvinylpyrrolidone (PVP) prepared by three different methods: melt quenching in the typical lab setting, spray drying and melt quenching in the NMR rotor while spinning. Of the five compositions prepared by melt quenching in the lab setting, the 95:5 and 90:10 NIF:PVP (w:w) amorphous solid dispersions were not miscible while 75:25, 60:40, and 50:50 NIF:PVP dispersions were miscible by the (1)H T1ρ measurements. The domain size of the miscible systems was estimated to be less than 4.5 nm. Amorphous solid dispersions with composition of 90:10 NIF:PVP prepared by spray drying and melt quenching in the NMR rotor showed miscibility by (1)H T1ρ values. Variable-temperature SSNMR (1)H T1ρ relaxation measurements revealed a change in relaxation time at approximately 20 °C below Tg, suggesting increased molecular mobility above that temperature.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536, United States.
authors.forename: Xiaoda
authors.initials: X
authors.lastname: Yuan
authors.forename: Diana
authors.initials: D
authors.lastname: Sperger
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Munson
mesh_terms: D002152:Calorimetry, Differential Scanning; D005079:Excipients / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009543:Nifedipine / Q000737:chemistry*; D010952:Plasma Substitutes / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D014665:Vasodilator Agents / Q000737:chemistry
chemical_list: D005079:Excipients; D010952:Plasma Substitutes; D014665:Vasodilator Agents; D011205:Povidone; D009543:Nifedipine