title: Pulmonary adenocarcinoma with osseous metaplasia: a rare occurrence possibly associated with early stage?
abstract: Adenocarcinoma is the most common type of malignant pulmonary tumor, but osseous metaplasia of this tumor is extremely rare. To date, only 21 cases have been reported in the literature worldwide. Here, we report a case of primary pulmonary adenocarcinoma with benign osseous stromal metaplasia in a 60-year-old woman and discuss the pathogenesis of intratumoral ossification and review the relevant literature. We found that pulmonary adenocarcinoma with osseous metaplasia may be more likely to occur in early tumor stages.
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, People's Republic of China.
authors.forename: Qingfu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Liying
authors.initials: L
authors.lastname: Yin
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Meng
authors.forename: Runa
authors.initials: R
authors.lastname: Dao
authors.forename: Suxiang
authors.initials: S
authors.lastname: Hu
authors.forename: Xueshan
authors.initials: X
authors.lastname: Qiu
keywords: immunohistochemistry; osseous metaplasia; pulmonary adenocarcinoma