title: Autobiographical memory and its association with neuropsychological function in bipolar disorder.
abstract: OBJECTIVE
  The aim of this study was to investigate the overgeneralization of autobiographical memory (AM) in bipolar disorder (BD) and assess its association with multiple cognitive domains.
  
  
  METHODS
  Twenty-eight clinically stable bipolar I patients and an equal number of age- and gender-matched healthy controls (HC) were included. All participants were examined using the autobiographical memory test (AMT) and the neuropsychological battery including the general intelligence, attention, verbal memory, verbal fluency, visual memory, and executive functions domain. Demographic, clinical, and test variables were compared between BD and HC groups. Correlation analyses of AMT scores with cognitive functions were performed within each group, controlling for demographic and clinical variables.
  
  
  RESULTS
  Total and negative scores of AMT were significantly lower in BD patients compared to HC individuals. AMT scores were significantly correlated with WAIS similarities, WCST perseverative errors, and WCST categories completed in BD, whereas AMT scores were correlated with verbal memory and verbal fluency in HC.
  
  
  CONCLUSIONS
  Our findings suggest that overgeneral AM is a characteristic of BD and is related to executive function. Future studies should investigate the benefit of additional treatment focusing on overgeneral AM in BD.
authors.affiliation: Department of Psychiatry, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Ra Yeon
authors.initials: RY
authors.lastname: Ha
authors.affiliation: Department of Psychiatry, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Ja Yeun
authors.initials: JY
authors.lastname: Sun
authors.affiliation: Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University, Seoul, South Korea; Department of Psychiatry, College of Medicine, Konyang University, Daejeon, South Korea.
authors.forename: Vin
authors.initials: V
authors.lastname: Ryu
authors.affiliation: Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea.
authors.forename: Kyooseob
authors.initials: K
authors.lastname: Ha
authors.affiliation: Department of Psychiatry, College of Medicine, Yonsei University, Seoul, South Korea; Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University, Seoul, South Korea. Electronic address: chs0225@yuhs.ac.
authors.forename: Hyun-Sang
authors.initials: HS
authors.lastname: Cho
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D055815:Young Adult