title: Synthesis and antibacterial activity of novel curcumin derivatives containing heterocyclic moiety.
abstract: A series of curcumin derivatives containing heterocyclic moiety have been synthesized and evaluated for their antibacterial activities. The chemical structures of the synthesized compounds were verified on the basis of spectral data and elemental analyses. Investigation of antimicrobial activity of the derivatives demonstrated the ability to inhibit Gram-positive microorganisms with zone of inhibition ranging from 14-18 mm, MIC ranging between 0.0625 and 0.25 mg/mL. Among all tested derivatives, diazepine 4 exhibited remarkable potency against Gram-positive bacteria S. aureus. An extensive study is underway to optimize the effectiveness of diazepine type of compounds and to determine their mode of action.
authors.affiliation: Department of Chemistry, An-Najah National University, Nablus, West Bank, Palestine.
authors.forename: Othman
authors.initials: O
authors.lastname: A Hamed
authors.forename: Noha
authors.initials: N
authors.lastname: Mehdawi
authors.forename: Adham
authors.initials: A
authors.lastname: Abu Taha
authors.forename: Emad
authors.initials: E
authors.lastname: M Hamed
authors.forename: Mohammed
authors.initials: M
authors.lastname: A Al-Nuri
authors.forename: Ayman
authors.initials: A
authors.lastname: S Hussein
keywords: Antimicrobial activity; diazepine; disc diffusion; isoxazoles; pyrazoles