title: Lack of association of microvessel density with prognosis of renal cell carcinoma: evidence from meta-analysis.
abstract: To investigate microvessel density (MVD) and its association with prognosis of renal cell carcinoma (RCC) by means of a meta-analysis. We obtained published studies and extracted appropriate data, then did a meta-analysis to estimate the predictive role of MVD by combining estimated effect-size from individual studies. Analyses for overall survival (OS) and cancer-specific survival (CSS) were performed, separately. Subgroup analysis stratified by biomarkers were also performed for studies using CD34, factor VIII-related antigen (F VIII) and others, respectively. A total of 20 studies were included for meta-analyses including nine (four for F VIII, three for CD34, and two for others) for OS and 11 (two for F VIII, seven for CD34 and two for others) for CSS. There was no significance of MVD predicting OS or CSS of RCC. The pooled HR for OS was 0.910 (95% CI 0.824-1.006; P = 0.065) and CSS was 0.977 (95% CI: 0.915-1.043; P = 0.487). We failed to observe significant association between MVD and prognosis of RCC. Additional studies are needed to provide more precise evidences to support our results.
authors.affiliation: Department of Urology, Qilu Hospital, Shandong University, Wenhua Xi Road 107, 250012, Jinan, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.forename: Dongliang
authors.initials: D
authors.lastname: Yan
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Liu
authors.forename: Benkang
authors.initials: B
authors.lastname: Shi
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality* / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology*; D055806:Microvessels / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D016019:Survival Analysis