title: Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.
abstract: Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B-N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.
authors.affiliation: Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal. pedrogois@ff.ul.pt.
authors.forename: Pedro M S D
authors.initials: PM
authors.lastname: Cal
authors.forename: Raquel F M
authors.initials: RF
authors.lastname: Frade
authors.forename: Vijay
authors.initials: V
authors.lastname: Chudasama
authors.forename: Carlos
authors.initials: C
authors.lastname: Cordeiro
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
authors.forename: Pedro M P
authors.initials: PM
authors.lastname: Gois
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry / Q000378:metabolism*; D001897:Boronic Acids / Q000737:chemistry / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D004705:Endocytosis; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism*; D058975:Folate Receptor 1 / Q000378:metabolism*; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D015394:Molecular Structure; D009113:Muramidase / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D001555:Benzene Derivatives; D001897:Boronic Acids; D005456:Fluorescent Dyes; D058975:Folate Receptor 1; D005492:Folic Acid; D009113:Muramidase