title: Methylenetetrahydrofolate reductase and glutathione S-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: a case report.
abstract: BACKGROUND
  Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy.
  
  
  METHODS
  We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia.
  
  
  CONCLUSIONS
  Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive.
authors.affiliation: *Department of Hematology and Oncology, University Children's Hospital †Clinic of Gynecology and Obstetrics "Narodni front" ‡Institute of Medical and Clinical Biochemistry §Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Skoric
authors.forename: Joksic
authors.initials: J
authors.lastname: Ivana
authors.forename: Radic
authors.initials: R
authors.lastname: Tanja
authors.forename: Jakovljevic
authors.initials: J
authors.lastname: Jovana
authors.forename: Ivanovski
authors.initials: I
authors.lastname: Petar
authors.forename: Simic
authors.initials: S
authors.lastname: Tatjana
mesh_terms: D000208:Acute Disease; D014408:Biomarkers, Tumor / Q000235:genetics*; D002648:Child; D005434:Flow Cytometry; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D011379:Prognosis; D012074:Remission Induction
chemical_list: D014408:Biomarkers, Tumor; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C573423:MTHFR protein, human; C413545:glutathione S-transferase T1; C484555:GSTA1 protein, human; C490476:GSTO1 protein, human; C496556:GSTP1 protein, human