title: Evaluation of abnormal liver tests.
abstract: The routine use of serum biochemical tests allows for the detection of acute and chronic liver injury before the onset of symptoms. These tests consist of markers of hepatocellular injury (aminotransferases and APs); tests of liver metabolism (total bilirubin); and tests of liver synthetic function (serum albumin and PT). Noninvasive tests for assessment of liver fibrosis are promising tools for diagnosis and prognosis of patients with chronic liver disease. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional laboratory and imaging testing establish the cause of hepatobiliary disease in most cases.
authors.affiliation: Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, 1830 East Monument Street, Suite 428, Baltimore, MD 21287, USA.
authors.forename: Tinsay A
authors.initials: TA
authors.lastname: Woreta
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Alqahtani
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003937:Diagnosis, Differential; D019468:Disease Management; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods; D011379:Prognosis; D011516:Prothrombin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D000637:Transaminases / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D011516:Prothrombin; D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin
keywords: Alkaline phosphatase; Aminotransferases; Bilirubin metabolism; Cholestasis; Hepatocellular injury