title: A new approach for the synthesis of hyperbranched N-glycan core structures from locust bean gum.
abstract: A novel protocol for the synthesis of general N-glycan core structures was established by means of Manβ(1→4)Man peracetate derived from a naturally abundant locust bean gum as a key starting material. Phenyl (2-O-benzyl-4,6-O-benzylidine-β-D-mannopyranosyl)-(1→4)-3,6-di-O-benzyl-2-azido-2-deoxy-1-thio-β-D-glucopyranoside facilitated the synthesis of key intermediates leading to hyperbranched N-glycan core structures.
authors.affiliation: Division of Drug Discovery Research, Faculty of Advanced life Science and Graduate School of Life Science, Hokkaido University , N21, W11, Kita-ku, Sapporo 001-0021, Japan, and Medicinal Chemistry Pharmaceuticals, Co. Ltd., N21, W12, Kita-ku, Sapporo 001-0021, Japan.
authors.forename: H V
authors.initials: HV
authors.lastname: Ravi Kumar
authors.forename: Kentaro
authors.initials: K
authors.lastname: Naruchi
authors.forename: Risho
authors.initials: R
authors.lastname: Miyoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hinou
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D002236:Carbohydrate Conformation; D005685:Galactans / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D008969:Molecular Sequence Data; D053149:Plant Gums / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; C017471:locust bean gum