title: Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones.
abstract: Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fazel
authors.initials: F
authors.lastname: Shamsa
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Hashim
authors.initials: H
authors.lastname: Shamsa
authors.forename: Nasrin
authors.initials: N
authors.lastname: Samadi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
keywords: Anthracene derivatives; In-vitro antibacterial activity; N-substituted piperazinyl quinolones; Phenanthrene derivatives