title: Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.
abstract: Genetic variants at 1q22 and 10q23 were identified as genetic markers of both gastric cancer and esophageal squamous cell carcinoma susceptibility by two genome-wide association studies. The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3,245 patients with gastric cancer and 1,700 controls. The allele frequencies of rs4072037G and rs2274223G were 11.2 and 25.5% among patients with gastric cancer, compared with 12.8 and 26.4%, respectively, among controls. We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95% confidence interval (CI) = 0.67-0.91 for AG vs AA]. Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95% CI = 0.76-0.99 for AG vs AA). Our data suggest that genetic variants at 1q22 and 10q23 play a role in gastric carcinogenesis.
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1-dong, Dong-gu,, Gwangju, 501-746, South Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Shim
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Ik Joo
authors.initials: IJ
authors.lastname: Chung
authors.forename: Young-Kyu
authors.initials: YK
authors.lastname: Park
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Yoo-Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Kyung Woong
authors.initials: KW
authors.lastname: Joo
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000235:genetics*; D009367:Neoplasm Staging; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1; D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon