title: Treatment of KPC-2 Enterobacter cloacae empyema with cefepime and levofloxacin.
abstract: Carbapenem-resistant Enterobacteriaceae infections are becoming more common, are associated with high mortality rates, and are difficult to treat due to multiple mechanisms of resistance. We describe the successful treatment of Klebsiella pneumoniae carbapenemase-expressing Enterobacter cloacae empyema in a lung transplant recipient with cefepime and levofloxacin.
authors.affiliation: Infectious Disease Service Brooke Army Medical Center, Houston, TX, USA. Electronic address: anthony.p.cardile.mil@mail.mil.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Cardile
authors.affiliation: Department of Medicine University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Briggs
authors.affiliation: Department of Medicine University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: S Rodrigo
authors.initials: SR
authors.lastname: Burguete
authors.affiliation: Department of Microbiology University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Herrera
authors.affiliation: Department of Microbiology University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
authors.affiliation: Department of Medicine University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Microbiology University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Pathology University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: James H
authors.initials: JH
authors.lastname: Jorgensen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000077723:Cefepime; D002511:Cephalosporins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004653:Empyema / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D016972:Enterobacter cloacae / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D064704:Levofloxacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D064704:Levofloxacin; D000077723:Cefepime; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases
keywords: Carbapenemase; Empyema; Enterobacter cloacae; KPC