title: Chemokines in tumor progression and metastasis.
abstract: Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, melanoma, lung cancer, gastric cancer, acute lymphoblastic leukemia, colon cancer, non-small lung cancer, non-hodgkin's lymphoma, etc. The expression of chemokines and their receptors is altered in many malignancies and leads to aberrant chemokine receptor signaling. This review focuses on the role of chemokines in key processes that facilitate tumor progression including proliferation, senescence, angiogenesis, epithelial mesenchymal transition, immune evasion and metastasis.
authors.affiliation: The Brain Tumor Center, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Purvaba J
authors.initials: PJ
authors.lastname: Sarvaiya
authors.forename: Donna
authors.initials: D
authors.lastname: Guo
authors.forename: Ilya
authors.initials: I
authors.lastname: Ulasov
authors.forename: Patrik
authors.initials: P
authors.lastname: Gabikian
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D018925:Chemokines