title: Secondary metabolites from the fungus Emericella nidulans.
abstract: A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans, together with koninginin E (2), koninginin A (3), trichodermatide B (4), citrantifidiol (5), (4S,5R)-4-hydroxy-5-methylfuran-2-one (6), the glycerol derivatives gingerglycolipid B (7), (2S)-bis[9Z,12Z]-1-O, 2-O-dilinoleoyl-3-O-[alpha-D-galactopyranosyl-(1" --> 6') beta-D-galactopyranosyl]glycerol (8), (2S)-bis[9Z,12Z]-1-O, 2-O-dilinoleoyl-3-O-beta-D-galactopyranosylglycerol (9), the cerebroside flavuside B (10), and the known sterols beta-sitosterol glucoside and ergosta-5,7,22-trien-3-ol. Their structures were established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC) and mass spectrometry. The antibacterial, antimalarial, antifungal and antileishmanial activities of compounds 1-10 were examined and the results indicated that compound 4 showed good antifungal activity against Cryptococcus neoformans with an IC50 value of 4.9 microg/mL.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Amer H
authors.initials: AH
authors.lastname: Tarawneh
authors.forename: Francisco
authors.initials: F
authors.lastname: León
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Luiz H
authors.initials: LH
authors.lastname: Rosa
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Cutler
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification*; D032842:Emericella / Q000737:chemistry* / Q000378:metabolism; D006574:Heterocyclic Compounds, 2-Ring / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D064210:Secondary Metabolism
chemical_list: D000890:Anti-Infective Agents; D006574:Heterocyclic Compounds, 2-Ring; C585677:koninginin H