title: Randomized clinical trial to compare negative-pressure wound therapy approaches with low and high pressure, silicone-coated dressing, and polyurethane foam dressing.
abstract: BACKGROUND
  This study was designed to compare two approaches to negative-pressure wound therapy: 125-mmHg pressure with a polyurethane foam dressing and 75-mmHg pressure with a silicone-coated dressing.
  
  
  METHODS
  Forty patients with diabetic foot wounds, after incision and drainage or amputation for infection, were assigned randomly to negative-pressure wound therapy with 75-mmHg continuous pressure with a silicone-covered dressing (75-mmHg group) or 125-mmHg with a polyurethane foam dressing (125-mmHg group) for up to 4 weeks or until surgical closure.
  
  
  RESULTS
  There was no difference in the proportion of wounds that were closed surgically (75-mmHg group, 50 percent; 125-mmHg group, 60 percent), wounds that demonstrated 50 percent wound area reduction (75-mmHg group, 65 percent; 125-mmHg group, 80 percent), or wounds that demonstrated 50 percent wound volume reduction after 4 weeks of therapy (75-mmHg group, 95 percent; 125-mmHg group, 90 percent).
  
  
  CONCLUSIONS
  The authors' results suggest that there was no difference in outcomes in wounds treated with low pressure (75 mmHg) with a silicone-coated interface and high pressure (125 mmHg) with a polyurethane foam interface.
  
  
  METHODS
  Therapeutic, II.
authors.affiliation: Dallas, Texas; and Washington, D.C. From the Departments of Plastic Surgery and Medicine, University of Texas Southwestern Medical Center; and the Department of Plastic Surgery, Georgetown University.
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Lavery
authors.forename: Javier
authors.initials: J
authors.lastname: La Fontaine
authors.forename: Gaurav
authors.initials: G
authors.lastname: Thakral
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kim
authors.forename: Kavita
authors.initials: K
authors.lastname: Bhavan
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Davis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D017719:Diabetic Foot / Q000601:surgery*; D016523:Foot Ulcer / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D011140:Polyurethanes / Q000008:administration & dosage; D011312:Pressure; D012828:Silicones / Q000008:administration & dosage; D014945:Wound Healing; D055815:Young Adult
chemical_list: D011140:Polyurethanes; D012828:Silicones; C028279:polyurethane foam