title: A brief review of methods for terminal functionalization of DNA.
abstract: The functionalized DNA has been widely developed and played a more and more important role in life science and material science during last decades. Therefore, methods to effectively endue DNA new functions by modifying DNA have been developed quickly. In this review, we will give an introduction in the methods for covalent terminal functionalization of DNA, including solid-phase functionalization and solution coupling functionalization, mainly on the technical aspect. The application of these functionalized DNA will be also introduced.
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Yuanchen
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. Electronic address: zyang@tsinghua.edu.cn.
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis*; D049329:Nanostructures / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques; D012996:Solutions
chemical_list: D000577:Amides; D010756:Phosphoric Acids; D012996:Solutions; D003300:Copper; D004247:DNA; C011067:phosphoramidic acid
keywords: DNA; Solid-phase functionalization; Solution coupling functionalization; Terminal functionalization