title: Prophylactic fibrinogen administration during complex congenital cardiac surgery leading to thrombosis of a patient's brachial artery and the cardiopulmonary bypass circuit: a case report.
abstract: Cardiac surgery represents one of the largest consumers of blood products due to the level of blood loss in these patients. As such, there is considerable interest in hemostatic therapies for this patient population. A hemostatic agent that has recently garnered interest is fibrinogen. The conversion of fibrinogen to fibrin by activated thrombin results in clot formation, leading to hemostasis. Currently, a number of studies are underway to evaluate the efficacy of fibrinogen concentrate in cardiac surgery patients. While potentially beneficial in hemostasis for cardiac patients, the current case report provides evidence of the importance of timing in the administration of this product.
authors.affiliation: Department of Clinical Perfusion Services, Capital District Health Authority, Canada Roger.Stanzel@cdha.nshealth.ca.
authors.forename: Rdp
authors.initials: R
authors.lastname: Stanzel
authors.affiliation: Department of Clinical Perfusion Services, Capital District Health Authority, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Henderson
authors.affiliation: Department of Cardiac Surgery, Capital District Health Authority, Canada.
authors.forename: Sb
authors.initials: S
authors.lastname: O'Blenes
keywords: cardiac surgery; cardiopulmonary bypass; coagulation; fibrinogen; heart/lung machine; hemostasis