title: Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.
abstract: OBJECTIVE
  Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers.
  
  
  METHODS
  Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured at four different time points during an intensive care unit admission.
  
  
  RESULTS
  Plasma NGAL detected AKI with an optimal area under the curve at 8 h after admission (0.86; p = 0.004) and at 4 h after admission for urinary NGAL (0.80; p = 0.012). The other markers failed to detect AKI.
  
  
  CONCLUSIONS
  NGAL is a promising biomarker for detecting AKI in patients after liver transplantation.
authors.affiliation: Department of Nephrology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Burç
authors.initials: B
authors.lastname: Dedeoglu
authors.forename: Hilde R H
authors.initials: HR
authors.lastname: de Geus
authors.forename: Gijs
authors.initials: G
authors.lastname: Fortrie
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D000209:Acute-Phase Proteins; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D005982:Glutathione Transferase / Q000097:blood; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007362:Intensive Care Units; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood; D016031:Liver Transplantation; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000097:blood; D012372:ROC Curve; D011991:Receptors, Virus / Q000097:blood
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D003404:Creatinine; D005982:Glutathione Transferase