title: Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy.
abstract: A relationship between serum basal tryptase (sBT) levels, anaphylactic reactions, and clonal mast cell diseases was shown recently in adults with venom allergy, but the relationship between sBT levels and IgE-mediated food allergy and anaphylaxis is not known. In this study, children with food allergy (FA; n = 167) were analyzed in two groups according to the presence (FA+/A+; n = 79) or absence of anaphylaxis (FA+/A-; n = 88) and were compared with a control group (n = 113). Median sBT values in FA+/A+, FA+/A-, and control groups were 4.0 ng/ml (2.8-5.8), 3.6 (2.3-4.5), and 3.3 (2.4-4.4), respectively (P = 0.022). sBT measurements higher than the cutoff values of 5.7 and 14.5 were associated with 50% and 90% predicted probabilities, respectively, of moderate to severe anaphylaxis. Children with tree nuts/peanut allergies had significantly higher levels of sBT than children with milk and egg allergy (P = 0.022). Results suggest that sBT levels may predict moderate to severe anaphylaxis in children with food allergy, which may follow a particular pattern according to the food allergy phenotype.
authors.affiliation: Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: U M
authors.initials: UM
authors.lastname: Sahiner
authors.forename: S T
authors.initials: ST
authors.lastname: Yavuz
authors.forename: B
authors.initials: B
authors.lastname: Buyuktiryaki
authors.forename: O
authors.initials: O
authors.lastname: Cavkaytar
authors.forename: E A
authors.initials: EA
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Tuncer
authors.forename: C
authors.initials: C
authors.lastname: Sackesen
mesh_terms: D000707:Anaphylaxis / Q000097:blood* / Q000201:enzymology* / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood* / Q000150:complications / Q000201:enzymology*; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D053802:Tryptases / Q000097:blood*
chemical_list: D015415:Biomarkers; D053802:Tryptases
keywords: anaphylaxis; children; food allergy; tree nut allergy; tryptase