title: Metabolism and distribution of primaquine in monkeys.
abstract: Rhesus monkeys were administered primaquine diphosphate (6.0 to 10.5 mg/kg, I.V.), and plasma samples were analyzed by high performance liquid chromatography for the presence of the unchanged drug and the major metabolite , 8-(3-carboxy-l-methylpropylamino)-6-methoxyquinoline (II). Primaquine had an unusually high affinity for tissue compartments which produced a rapid initial drop in plasma concentration. Within 15 minutes, the plasma concentration of II far exceeded that of primaquine. 35 to 83 % of the primaquine dose was converted to II; moreover, metabolite II possessed much lower affinity for the tissue compartments than primaquine itself.
authors.affiliation: Department of Medicinal Chemistry, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Baker
authors.forename: J A
authors.initials: JA
authors.lastname: Bedford
authors.forename: A M
authors.initials: AM
authors.lastname: Clark
authors.forename: J D
authors.initials: JD
authors.lastname: McChesney