title: The effect of placebo adherence on reducing cardiovascular mortality: a meta-analysis.
abstract: OBJECTIVE
  We aim to demonstrate the effect of placebo adherence on reducing CV mortality.
  
  
  BACKGROUND
  Good adherence, whether to drug or placebo treatment, is associated with lower CV mortality. However, current evidence for the positive effect of placebo adherence on reducing CV mortality is relatively weak.
  
  
  METHODS
  We conducted a fixed-effect meta-analysis of eight randomized clinical trials to evaluate the effect of placebo adherence on reducing CV mortality. We made a comparison between good placebo adherence and poor drug adherence.
  
  
  RESULTS
  Compared with poor adherence to drug treatment, good adherence to placebo treatment was associated with lower CV mortality (OR = 0.68, 95% CI 0.60-0.77).
  
  
  CONCLUSIONS
  Good adherence to placebo has a positive effect on reducing CV mortality. The effect of adherence on reducing CV mortality may be independent of the drug effect.
authors.affiliation: Department of Pharmacy, Huashan Hospital, Fudan University, 12 Middle Wu Lu Mu Qi Road, Shanghai, 200040, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yue
authors.forename: Cheng
authors.initials: C
authors.lastname: Cai
authors.forename: Yang
authors.initials: Y
authors.lastname: Ai-Fang
authors.forename: Tang
authors.initials: T
authors.lastname: Feng-Min
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Wang
authors.initials: W
authors.lastname: Bin
mesh_terms: D002317:Cardiovascular Agents / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000401:mortality*; D016009:Chi-Square Distribution; D006801:Humans; D055118:Medication Adherence; D016017:Odds Ratio; D015990:Placebo Effect; D010919:Placebos / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D010919:Placebos