title: Effect of non-steroid anti-inflammatory drugs on neurovascular coupling in humans.
abstract: OBJECTIVE
  Neuronal activation induced cerebral blood flow increase was shown in animal experiments to require the presence of functioning cyclooxygenase. Our aim was to study whether widely used, non-steroid anti-inflammatory drugs (NSAIDs), given orally in usual therapeutic doses, inhibit neurovascular coupling in humans.
  
  
  METHODS
  By using a visual cortex stimulation paradigm, the flow velocity response was measured by transcranial Doppler sonography in both posterior cerebral arteries of fifteen young healthy adults. The investigation was repeated in the same subjects after 2-day administration of 3×25 mg indomethacin (indomethacin phase) and 2×550 mg naproxen (naproxen phase). Visual-evoked-potentials were also recorded during the control phase and after administration of NSAIDs.
  
  
  RESULTS
  Basal flow velocity significantly decreased while the pulsatility index increased after administration of either indomethacin or naproxen (p<0.01). Despite unchanged visual-evoked-potentials, the visually evoked flow velocity increase (26±7% in the control phase) significantly declined after administration of indomethacin (19±5%; p<0.01) or naproxen (20±5%; p<0.02).
  
  
  CONCLUSIONS
  Oral administration of indomethacin or naproxen in their usual therapeutic doses significantly impaired the resting and the visually evoked blood flow regulations in healthy human subjects. Together with stable evoked potentials, our findings indicate disturbance of neurovascular coupling.
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Szabo
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Rosengarten
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary.
authors.forename: Tunde
authors.initials: T
authors.lastname: Juhasz
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Lako
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Csiba
authors.affiliation: Department of Neurology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Moricz Zs. str. 22, Hungary. Electronic address: olah@med.unideb.hu.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Olah
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Cerebral blood flow; Cerebral vasoconstriction; Neurovascular coupling; Non-steroid anti-inflammatory drugs; Transcranial Doppler; Visual stimulation