title: Levetiracetam-induced anaphylaxis in a neonate.
abstract: BACKGROUND
  Neonatal seizures are often refractory to treatment with initial antiseizure medications. Clinicians turn to agents such as levetiracetam despite the paucity of published data regarding its safety, tolerability, or efficacy in the neonatal population.
  
  
  METHODS
  We describe a neonate who developed anaphylactic shock developing after receiving intravenous levetiracetam.
  
  
  RESULTS
  This is the first neonate to develop anaphylactic shock due to intravenous administration of levetiracetam.
  
  
  CONCLUSIONS
  Clinicians should be aware of this potentially fatal adverse effect occurring with intravenous levetiracetam in newborns.
authors.affiliation: Department of Neonatology, Megapark Hospital, Kahramanmaraş, Turkey. Electronic address: esadsena@yahoo.com.tr.
authors.forename: Esad
authors.initials: E
authors.lastname: Koklu
authors.affiliation: Department of Obstetrics and Gynecology, Megapark Hospital, Kahramanmaras, Turkey.
authors.forename: Erdal Avni
authors.initials: EA
authors.lastname: Ariguloglu
authors.affiliation: Department of Pediatrics, Turkey Ministry of Health Necip Fazıl Hospital, Kahramanmaras, Turkey.
authors.forename: Selmin
authors.initials: S
authors.lastname: Koklu
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D001238:Asphyxia Neonatorum / Q000150:complications; D000075202:Contraindications; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced / Q000378:metabolism; D005145:Face / Q000473:pathology; D005316:Fetal Distress; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007866:Leg / Q000473:pathology; D000077287:Levetiracetam; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011030:Pneumothorax / Q000150:complications; D012535:Scalp / Q000473:pathology; D012640:Seizures / Q000150:complications / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
keywords: anaphylaxis; levetiracetam; newborn; seizure