title: Nakagami imaging for detecting thermal lesions induced by high-intensity focused ultrasound in tissue.
abstract: High-intensity focused ultrasound induces focalized tissue coagulation by increasing the tissue temperature in a tight focal region. Several methods have been proposed to monitor high-intensity focused ultrasound-induced thermal lesions. Currently, ultrasound imaging techniques that are clinically used for monitoring high-intensity focused ultrasound treatment are standard pulse-echo B-mode ultrasound imaging, ultrasound temperature estimation, and elastography-based methods. On the contrary, the efficacy of two-dimensional Nakagami parametric imaging based on the distribution of the ultrasound backscattered signals to quantify properties of soft tissue has recently been evaluated. In this study, ultrasound radio frequency echo signals from ex vivo tissue samples were acquired before and after high-intensity focused ultrasound exposures and then their Nakagami parameter and scaling parameter of Nakagami distribution were estimated. These parameters were used to detect high-intensity focused ultrasound-induced thermal lesions. Also, the effects of changing the acoustic power of the high-intensity focused ultrasound transducer on the Nakagami parameters were studied. The results obtained suggest that the Nakagami distribution's scaling and Nakagami parameters can effectively be used to detect high-intensity focused ultrasound-induced thermal lesions in tissue ex vivo. These parameters can also be used to understand the degree of change in tissue caused by high-intensity focused ultrasound exposures, which could be interpreted as a measure of degree of variability in scatterer concentration in various parts of the high-intensity focused ultrasound lesion.
authors.affiliation: Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Rangraz
authors.forename: Hamid
authors.initials: H
authors.lastname: Behnam
authors.forename: Jahan
authors.initials: J
authors.lastname: Tavakkoli
mesh_terms: D000818:Animals; D057086:High-Intensity Focused Ultrasound Ablation / Q000009:adverse effects*; D008954:Models, Biological; D009132:Muscles / Q000528:radiation effects; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D016008:Statistical Distributions; D013552:Swine; D014159:Transducers; D014463:Ultrasonography / Q000379:methods*
keywords: High-intensity focused ultrasound lesion detection; Nakagami distribution; ultrasound backscattered signal statistics