title: miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies.
abstract: Digestive tumors have the highest incidence among all tumor types worldwide. miR-146a has been shown to play an important role in the development, apoptosis, invasion and metastasis of digestive tumors. Additionally, a miR-146a gene polymorphism has been associated with the risk of a variety of cancer types in the digestive system. Therefore, in order to investigate the correlation, a meta-analysis of reported data was conducted, for which we obtained 21 research studies concerning the association between the miR-146a gene polymorphism and digestive tumors. Odds ratio (OR) values and 95% confidence intervals (95% CI) were used to assess this association. We found that the miR-146a polymorphism rs2910164 might significantly increase the susceptibility of digestive tumors, in particular for esophageal cancer and colorectal cancers. Furthermore, the miR-146a polymorphism might significantly increase the risk of digestive tumors in Asians. However, no obvious correlation between the polymorphism and the risk for digestive tumors was found in Caucasians.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P.R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Xu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yang
authors.forename: Gan
authors.initials: G
authors.lastname: Ru
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Shuyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Chungen
authors.initials: C
authors.lastname: Xing
authors.forename: Yongyou
authors.initials: Y
authors.lastname: Wu
authors.forename: Jianping
authors.initials: J
authors.lastname: Cao
mesh_terms: D044466:Asian People / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs