title: [Comparison study of three methods of digestive tract reconstruction after radical gastrectomy in gastric cancer patients].
abstract: OBJECTIVE
  To investigate the ideal digestive tract reconstruction methods among three different surgical methods after radical gastrectomy of gastric cancer patients.
  
  
  METHODS
  A total of 123 patients who received elective radical gastrectomy for gastric cancer from February 2010 to August 2011 were prospectively enrolled and randomly divided into radical proximal gastrectomy and jejunal interposition group, radical proximal gastrectomy and esophageal with the posterior of residual-stomach group, and radical total gastrectomy and Roux-en-Y esophagojejunostomy group. Patients were followed up for 12 months. Symptoms of reflux esophagitis were observed, gastric emptying tests were done, liver and kidney function was also monitored. The quality of life was documented before operation, and one and twelve months after operation.
  
  
  RESULTS
  No significant differences were found among these three groups in the pH value of lower part of esophagus, the blood regular test results and the functional parameters of kidney and liver before and after operation(all P>0.05). Symptoms of reflux esophagitis was reported in 1(2.4%) patients in the jejunal interposition group, 10(24.4%) in esophageal with the posterial of residual-stomach group, and 7(17.1%) in the Roux-en-Y esophagojejunostomy group(P=0.017). There was 1(2.4%), 10(17.1%), and 8(19.5%) patients presented reflux of barium meal in these three groups, respectively (P=0.046). There were no statistically significant difference in PH at the distal esophagus(6.9±0.2 vs. 6.8±0.1 vs. 6.9±0.1, P=0.196). The quality of life was significantly improved one year after surgery in terms of general status, physical function, emotional function, fatigue, nausea/vomiting, pain, constipation, and diarrhea (all P<0.05), with the jejunal interposition superior than the other two methods.
  
  
  CONCLUSIONS
  Three methods of digestive tract reconstruction in radical gastrectomy of gastric cancer patients can improve the health status and the quality of life in gastric cancer patients. Radical proximal gastrectomy and jejunal interposition is the preferred method.
authors.affiliation: Department of General Surgery, The Affiliated Tumor Hospital, Zhengzhou University, Zhengzhou 450003, China. yaweihua@qq.com.
authors.forename: Zhan-dong
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Ma
authors.forename: Yong-lei
authors.initials: YL
authors.lastname: Zhang
authors.forename: Er-min
authors.initials: EM
authors.lastname: Ma
authors.forename: Ye
authors.initials: Y
authors.lastname: Kong
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Liu
authors.forename: Ya-wei
authors.initials: YW
authors.lastname: Hua
mesh_terms: D000713:Anastomosis, Roux-en-Y; D000714:Anastomosis, Surgical; D013505:Digestive System Surgical Procedures; D004947:Esophagus; D005743:Gastrectomy; D005746:Gastric Emptying; D018530:Gastric Stump; D006801:Humans; D007583:Jejunum; D011788:Quality of Life; D019651:Plastic Surgery Procedures / Q000379:methods*; D013274:Stomach Neoplasms / Q000601:surgery*