title: Pregnancy outcomes for kidney transplant recipients.
abstract: Pregnancy outcomes in a transplant population have not been well documented. Data from the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) and the National Perinatal Epidemiology and Statistics Unit (NPESU) were analyzed. We described pregnancy outcomes within the transplant population and compared these to outcomes for the general population. Six hundred ninety-two pregnancies in 447 transplant recipients were reported between 1971 and 2010 (ANZDATA); a corresponding 5 269 645 pregnancies were reported nationally in Australia between 1991 and 2010 (NPESU). At pregnancy transplant mothers had a median age of 31 years (interquartile range [IQR]: 27, 34), a median creatinine of 106 µmol/L (IQR: 88, 1103 µmol/L) and a functioning transplant for a median of 5 years (IQR: 3, 9). The mean gestational age at birth was 35 ± 5 weeks in transplant recipients, significantly shorter than the national average of 39 weeks (p < 0.0001). Mean live birth weight for transplant recipients was 873 g lower than the national average (2485 ± 783 g vs. 3358 ± 2 g); a significant difference remained after controlling for gestational age. There was lower perinatal survival rate in babies born to transplant recipients, 94% compared with 99% nationally (p < 0.001). Although transplant pregnancies are generally successful, outcomes differ from the general population, indicating these remain high-risk pregnancies despite good allograft function.
authors.affiliation: Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia.
authors.forename: M L
authors.initials: ML
authors.lastname: Wyld
authors.forename: P A
authors.initials: PA
authors.lastname: Clayton
authors.forename: S
authors.initials: S
authors.lastname: Jesudason
authors.forename: S J
authors.initials: SJ
authors.lastname: Chadban
authors.forename: S I
authors.initials: SI
authors.lastname: Alexander
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia; D001724:Birth Weight; D005260:Female; D005307:Fertilization in Vitro; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009520:New Zealand; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011446:Prospective Studies; D012042:Registries; D051437:Renal Insufficiency / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome
keywords: ANZDATA; IVF; kidney; pregnancy; prematurity; transplantation