title: [Quality of life in adults with variable common immunodeficiency and bronchiectasis].
abstract: BACKGROUND
  Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia. Its prevalence is 1:10000 to 1:50000 with the highest incidence in children, 6 to 10 years, and in adults around age 29. The association of CVID and bronchiectasis has a prevalence of 17-90%. The quality of life in these patients can be assessed through instruments such as the Saint George Respiratory Questionnaire (SGRQ), which is designed for patients with chronic lung diseases and validated for the Mexican population.
  
  
  OBJECTIVE
  [corrected] To evaluate the quality of life in adult patients with CVID and bronchiectasis using the SGRQ.
  
  
  METHODS
  We applied CRSG to all the patients of the Immunodeficiencies Clinic from Hospital Especialidades CMN SXXI diagnosed with CVID and bronchiectasis for assessing quality of life which was evaluated in the three areas of application 1)Symptoms, 2)Activities and 3)Impact and the overall quality of life. We also analyzed its relationship with the severity of bronchiectasis confirmed by HRCT.
  
  
  RESULTS
  19 patients were included, (5 males, 14 women) in whom it was found affected the overall quality of life in 84.2%. Women showed higher scores for all areas of the SGRQ (♀ 28.3 ± 25.18 vs. ♂ 9.89 ± 8.14). The most affected area by both sexes was the Symptoms in 92% of women and 80% men. About the severity of bronchiectasis patients with mild bronquietasias presented scores 0-22.2 (x= 11.1 ± 15.6), those with moderate bronchiectasis 3.24-56.9 (x=25.5 ± 21.76) and severe with scores of 0-74.8 (x= 24.1 ± 28.5.).
  
  
  CONCLUSIONS
  Patients with CVID and bronchiectasis have impaired quality of life, mainly associated with respiratory symptoms, with less involvement of and impact areas. Females were most affected in intensity to show higher scores.
authors.affiliation: Servicio de Alergia e Inmunología Clínica. Hospital de Especialidades Bernardo Sepúlveda, IMSS, Centro Médico Nacional Siglo XXI, México, D.F. la_vanilla@hotmail.com.
authors.forename: Lucy Vania
authors.initials: LV
authors.lastname: Galindo-Pacheco
authors.forename: Adela Sisy
authors.initials: AS
authors.lastname: Amaya-Mejía
authors.forename: Patricia María
authors.initials: PM
authors.lastname: O'Farrill-Romanillos
authors.forename: Leonel Gerardo
authors.initials: LG
authors.lastname: Del Rivero-Hernández
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
mesh_terms: D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000150:complications*; D017074:Common Variable Immunodeficiency / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult