title: Synthesis of DNA/RNA and their analogs via phosphoramidite and H-phosphonate chemistries.
abstract: The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. subhadeep.roy@colorado.edu.
authors.forename: Subhadeep
authors.initials: S
authors.lastname: Roy
authors.forename: Marvin
authors.initials: M
authors.lastname: Caruthers
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D063065:Organophosphonates; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012313:RNA; D004247:DNA