title: [Treating menopause syndrome by kuntal capsule and hormone replacement therapy: a meta-analysis of efficacy and safety comparison].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of Kuntai Capsule (KC) and hormone replacement therapy (HRT) in treating menopause syndrome by Meta-analysis.
  
  
  METHODS
  Randomized controlled trials were electronically retrieved from PubMed, EMbase, The Cochrane Library, CBM, CNKI, Chinese Doctoral Dissertation Full Text Database, Chinese Outstanding Masters' Dissertation Full Text Database, and VIP database, Wanfang Database, and some other related papers were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of interventions and then effective data were analyzed by RevMan 5.0.2 Software.
  
  
  RESULTS
  Eight randomized control trials involving 675 patients were included. Results of Meta-analysis showed that there was no statistical difference in the Kupperman Menopausal Scores [MD = 1.91, 95% CI (-0.31, 4.12)] and the effective rate of Kupperman Menopausal Scores [OR = 1.37, 95% CI (0.66, 2.85)] between the KC group and the estrogen replacement therapy group (P > 0.05). Compared with the KC group, the E2 level [MD = -12.8, 95% CI (-22.85, -2.76)] and the FSH level [MD = 17.96, 95% CI (3.03, 32.88)] could be significantly improved in the estrogen replacement therapy group. Compared with the estrogen replacement group, KC could significantly reduce the total incidence of adverse reactions [OR = 0.41, 95% CI (0.24, 0.73)], the incidence of breast distending pain [OR = 0.65, 95% CI (0.42, 1.00)], and the incidence of vaginal bleeding [OR = 0.26, 95% CI (0.17, 0.40) ] (P < 0.05).
  
  
  CONCLUSIONS
  The current limited evidence showed that, when compared with the estrogen replacement therapy group, KC could also improve climacteric symptoms. It was inferior to the estrogen replacement therapy group in improving in vivo hormone levels. But it was superior in reducing the incidence of adverse reactions, breast distending pain, and vaginal bleeding.
authors.affiliation: Center for Drug Clinical Research, University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Cun-Cun
authors.initials: CC
authors.lastname: Li
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Li
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Zheng
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Liu
mesh_terms: D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008517:Phytotherapy / Q000009:adverse effects / Q000379:methods
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal