title: Comparison of short- and long-term outcomes after extralevator abdominoperineal excision and standard abdominoperineal excision for rectal cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Whether the introduction of extralevator abdominoperineal excision (ELAPE) improves survival and safety remains controversial. We conducted a systematic review and meta-analysis of all comparative studies to define the efficacy and safety of ELAPE and standard abdominoperineal excision (APE).
  
  
  METHODS
  A search for all major databases and relevant journals from inception to July 2013 without restriction on languages or regions was performed. Outcome measures were the oncological parameters of circumferential resection margin (CRM) involvement, intraoperative bowel perforation (IOP), and local recurrence, as well as other parameters of blood loss, operative time, length of hospitalization, and postoperative complication. The test of heterogeneity was performed with the Q statistic.
  
  
  RESULTS
  A total of 949 patients were included in the meta-analysis. Oncological pooled estimates of intraoperative bowel perforation rate (RR 0.34; 95 % CI 0.21-0.54; P < 0.00001), CRM involvement (RR 0.44; 95 % CI 0.34-0.56; P < 0.00001), and local recurrence (RR 0.32; 95 % CI 0.14-0.74; P = 0.008) all showed outcomes that were significantly lower in ELAPE than in APE. A similar incidence of postoperative complication was attributed to both groups, including overall complication (RR 0.93; 95 % CI 0.66-1.32; P = 0.69), perineal wound complication (RR 0.72; 95 % CI 0.33-1.55; P = 0.39), and urinary dysfunction (RR 1.53; 95 % CI 0.88-2.67; P = 0.13).
  
  
  CONCLUSIONS
  ELAPE has a lower intraoperative bowel perforation rate, positive CRM rate, and local recurrence rate than APE. There is evidence that in selected low rectal cancer patients, ELAPE is a more efficient and equally safe option to replace APE. Due to the inherent limitations of the present study, future randomized controlled trials will be useful to confirm this conclusion.
authors.affiliation: Department of Colorectal and Anal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, 510655, People's Republic of China.
authors.forename: Hui-Chuan
authors.initials: HC
authors.lastname: Yu
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Xiao-Sheng
authors.initials: XS
authors.lastname: He
authors.forename: Ri-Sheng
authors.initials: RS
authors.lastname: Zhao
mesh_terms: D000005:Abdomen / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000592:standards*; D006801:Humans; D010502:Perineum / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D017594:Publication Bias; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012015:Reference Standards; D016896:Treatment Outcome