title: Hydration of AMP and ATP molecules in aqueous solution and solid films.
abstract: Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia. dfaizullin@mail.ru.
authors.forename: Dzhigangir
authors.initials: D
authors.lastname: Faizullin
authors.forename: Nataliya
authors.initials: N
authors.lastname: Zakharchenko
authors.forename: Yuriy
authors.initials: Y
authors.lastname: Zuev
authors.forename: Alexander
authors.initials: A
authors.lastname: Puzenko
authors.forename: Evgeniya
authors.initials: E
authors.lastname: Levy
authors.forename: Yuri
authors.initials: Y
authors.lastname: Feldman
mesh_terms: D000249:Adenosine Monophosphate / Q000737:chemistry* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000737:chemistry* / Q000378:metabolism; D058266:Dielectric Spectroscopy; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000097:blood* / Q000737:chemistry; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D012996:Solutions / Q000737:chemistry; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D051272:Glucose Transporter Type 1; D007328:Insulin; C495677:SLC2A1 protein, human; D012996:Solutions; D014867:Water; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D005947:Glucose