title: Hemostasis, coagulation abnormalities, and liver disease.
abstract: Coagulopathy-related bleeding events are a major concern in the management of acute and chronic liver disease. The liver attempts to maintain a balance between procoagulant and anticoagulant factors, and providers struggle with poor prognostic indicators to manage bleeding and critical complications. Subtle changes in patient presentation that may require extensive provider-directed interventions, such as blood transfusions, intravenous fluid management, mitigating possible sepsis, and evaluating appropriate pharmacologic treatment, are discussed.
authors.affiliation: University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: c.mackavey@att.net.
authors.forename: Carole L
authors.initials: CL
authors.lastname: Mackavey
authors.forename: Robert
authors.initials: R
authors.lastname: Hanks
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000503:physiopathology*; D058625:End Stage Liver Disease; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D019934:International Normalized Ratio; D008107:Liver Diseases / Q000150:complications* / Q000503:physiopathology*; D017114:Liver Failure, Acute; D016031:Liver Transplantation; D010314:Partial Thromboplastin Time; D017713:Platelet Transfusion; D011486:Protein C / Q000502:physiology; D017293:Protein S / Q000502:physiology; D011517:Prothrombin Time
chemical_list: D011486:Protein C; D017293:Protein S
keywords: Anticoagulants; Coagulation abnormalities; Fibrinolysis; Hemostasis; Liver disease; Procoagulants