title: Evaluation of retinal nerve fiber layer thickness in migraine.
abstract: BACKGROUND
  Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in ganglion cell damage in patients with migraine.
  
  
  METHODS
  Sixty patients diagnosed with migraine and thirty normal individuals were evaluated in groups including migraine with aura, migraine without aura and controls. Retinal nerve fiber layer (RNFL) thickness was measured using stratus optical coherence tomography (OCT™) and then was compared in case and control groups.
  
  
  RESULTS
  RNFL thickness was only significantly thinner in nasal quadrant in migraineurs compared to the control group. Other parameters showed no difference between the two groups and besides there was no statistically difference between the two migraine subgroups.
  
  
  CONCLUSIONS
  Given the significant difference in nasal quadrant RNFL thickness between the migraineurs and normal individuals, we might be able to defend the retinal blood flow decrease theory in migraine; however, multicentre studies with larger samples seem mandatory.
authors.affiliation: Associate Professor, Department of Ophthalmology, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Rana
authors.initials: R
authors.lastname: Sorkhabi
authors.forename: Somaiyeh
authors.initials: S
authors.lastname: Mostafaei
authors.forename: Mohammadhosein
authors.initials: M
authors.lastname: Ahoor
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Talebi
keywords: Migraine; Optical Coherence Tomography; Retinal Nerve Fiber Layer Thickness