title: Clinical outcome of early-stage endometroid adenocarcinoma: a tertiary cancer center experience.
abstract: OBJECTIVE
  Endometrial cancer (EC) outcome data from developing countries are sparse. We undertook this retrospective analysis to report outcome in our patient population.
  
  
  METHODS
  Two hundred forty-nine patients with stage I and II and type I histology ECs referred/treated at our institution from 1998 to 2004 were analyzed. All the details including demographic profile, surgical and histopathological details, as well as International Federation of Gynecology and Obstetrics stage and adjuvant therapy were compiled. The 1988 International Federation of Gynecology and Obstetrics staging and risk stratification were performed on the basis of PORTEC risk groups.
  
  
  RESULTS
  With a median age of 54 years (26-72 years), 136 patients (55%) underwent surgery elsewhere; 118 (47.3%) underwent a complete surgical staging. There were 60 (24.1%), 124 (49.8%), 65 (26.1%) patients in the low-risk (LR), intermediate-risk (IR), and high-risk (HR) groups, respectively. Adjuvant radiation was given in 160 patients (LR, 18; IR, 85; and HR, 57). With a median follow-up of 36 months (mean, 40 months), 10 patients had vault recurrences, (LR, 3; IR, 4; and HR, 3), 11 had nodal (5 also had local recurrence; LR, 2; IR, 4; and HR, 5), and 16 had distant recurrences (3 also had nodal; LR, 4; IR, 5; HR, 7). The 5-year disease-free survival (DFS) and overall survival (OAS) rates were 80% and 95%, respectively. The DFS and OAS rates at 5 years were 84% and 97%, 85% and 98%, and 60% and 85% for the LR, IR, and HR groups, respectively. On multivariate analysis, grade (P = 0.002) and type of radiation (P = 0.027) had significant impact on DFS and OAS. Late toxicities (grade 3/4) were vaginal stenosis in 4 (1%) and radiation proctitis in 3 (1%) patients.
  
  
  CONCLUSIONS
  In our study, ECs are seen in relatively younger population. There is a trend toward incomplete staging surgery outside the oncological referral network. However, the clinical outcome for early-stage type I histology ECs within our population are similar to those reported in the literature.
authors.affiliation: Departments of *Radiation Oncology, †Medical Records and Epidemiology, ‡Surgical Oncology, §Medical Oncology, Tata Memorial Center, Mumbai, India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Mahantshetty
authors.forename: Aditi
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Balasubramanium
authors.initials: B
authors.lastname: Ganesh
authors.forename: Sushama
authors.initials: S
authors.lastname: Saoba
authors.forename: Safoora
authors.initials: S
authors.lastname: Mulla
authors.forename: Reena
authors.initials: R
authors.lastname: Engineer
authors.forename: Supriya
authors.initials: S
authors.lastname: Chopra
authors.forename: Amita
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Rajendra
authors.initials: R
authors.lastname: Kerkar
authors.forename: Shylasree
authors.initials: S
authors.lastname: T S
authors.forename: Jaya
authors.initials: J
authors.lastname: Ghosh
authors.forename: Sudeep
authors.initials: S
authors.lastname: Gupta
authors.forename: Shyamkishore
authors.initials: S
authors.lastname: Shrivasatava
mesh_terms: D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D003906:Developing Countries / Q000706:statistics & numerical data*; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000706:statistics & numerical data