title: Probiotics, prebiotics, and the host microbiome: the science of translation.
abstract: Recent advances in our understanding of the community structure and function of the human microbiome have implications for the potential role of probiotics and prebiotics in promoting human health. A group of experts recently met to review the latest advances in microbiota/microbiome research and discuss the implications for development of probiotics and prebiotics, primarily as they relate to effects mediated via the intestine. The goals of the meeting were to share recent advances in research on the microbiota, microbiome, probiotics, and prebiotics, and to discuss these findings in the contexts of regulatory barriers, evolving healthcare environments, and potential effects on a variety of health topics, including the development of obesity and diabetes; the long-term consequences of exposure to antibiotics early in life to the gastrointestinal (GI) microbiota; lactose intolerance; and the relationship between the GI microbiota and the central nervous system, with implications for depression, cognition, satiety, and mental health for people living in developed and developing countries. This report provides an overview of these discussions.
authors.affiliation: Transcend Biomedical Communications, LLC, Youngsville, North Carolina.
authors.forename: Bryon
authors.initials: B
authors.lastname: Petschow
authors.forename: Joël
authors.initials: J
authors.lastname: Doré
authors.forename: Patricia
authors.initials: P
authors.lastname: Hibberd
authors.forename: Timothy
authors.initials: T
authors.lastname: Dinan
authors.forename: Gregor
authors.initials: G
authors.lastname: Reid
authors.forename: Martin
authors.initials: M
authors.lastname: Blaser
authors.forename: Patrice D
authors.initials: PD
authors.lastname: Cani
authors.forename: Fred H
authors.initials: FH
authors.lastname: Degnan
authors.forename: Jane
authors.initials: J
authors.lastname: Foster
authors.forename: Glenn
authors.initials: G
authors.lastname: Gibson
authors.forename: John
authors.initials: J
authors.lastname: Hutton
authors.forename: Todd R
authors.initials: TR
authors.lastname: Klaenhammer
authors.forename: Ruth
authors.initials: R
authors.lastname: Ley
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
authors.forename: Bruno
authors.initials: B
authors.lastname: Pot
authors.forename: David
authors.initials: D
authors.lastname: Relman
authors.forename: Andrew
authors.initials: A
authors.lastname: Serazin
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Sanders
mesh_terms: D003071:Cognition; D003226:Congresses as Topic; D003863:Depression / Q000628:therapy; D003920:Diabetes Mellitus / Q000628:therapy; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007787:Lactose Intolerance / Q000628:therapy; D008603:Mental Health; D064307:Microbiota; D009765:Obesity / Q000628:therapy; D056692:Prebiotics / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use*; D057170:Translational Research, Biomedical
chemical_list: D056692:Prebiotics
keywords: health disorders; intestinal microbiota; microbiome; prebiotics; probiotics