title: [Pre-diabetes mellitus influenced by hyperuricemia].
abstract: OBJECTIVE
  To investigate the relationship and the influence between pre-diabetes mellitus (PDM) and hyperuricemia (HUA).
  
  
  METHODS
  157 PDM patients, aged 20 to 75 years old were selected from the Second Clinical Medical College of Harbin Medical University, from 2009 February to 2010 February and were divided into HUA group (76 cases) and NUA group (81 cases). All the patients had not been on thiazide drugs. T-test and Pearson correlation analysis were used to calculate the differences and correlation between uric acid and biochemical indicators.
  
  
  RESULTS
  In the HUA group,BMI was (27.74±2.88 ) kg/m(2), waist to height ratio (WSR) was(0.55 ± 0.41), TC was (6.61 ± 0.73) mmol/L, TG was(3.94 ± 1.97) mmol/L, LDL-C was (3.60 ± 0.45) mmol/L and homeostasis model assessment-insulin resistance index (HOMA-IR) was (3.09 ± 1.20). There were significant differences noticed in BMI, TG, TC, LDL-C, HOMA-IR at higher level in the HUA group than those in the NUA group. Pre-diabetes uric acid levels were positively correlated with TG, TC, LDL-C while HOMA-IR(TG:r = 0.29, TC:r = 0.33,LDL-C:r = 0.49, HOMA-IR:r = 0.51, P < 0.05) was negatively correlated (r = -0.30, P < 0.05)with the HbA1c.
  
  
  CONCLUSIONS
  The levels of PDM uric acid might both be related with TC, TG, LDL-C and HOMA-IR. The High level of uric acid status in vivo appeared closely related to HOMA-IR, which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia. Our findings suggested that the levels of pre-diabetes uric acid levels should be under concern.
authors.affiliation: Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Jiao
authors.forename: Han-lu
authors.initials: HL
authors.lastname: Gao
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Zhan-ping
authors.initials: ZP
authors.lastname: Jia
authors.forename: Da-peng
authors.initials: DP
authors.lastname: Li
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Sun
authors.forename: Bin-you
authors.initials: BY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D033461:Hyperuricemia; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood* / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid