title: Short-term antidepressant administration reduces default mode and task-positive network connectivity in healthy individuals during rest.
abstract: Resting-state studies in depressed patients have revealed increased connectivity within the default mode network (DMN) and task-positive network (TPN). This has been associated with heightened rumination, which is the tendency to repetitively think about symptoms of distress. Here, we performed a pharmacological neuroimaging study in healthy volunteers to investigate whether short-term antidepressant administration could reduce DMN connectivity. We recorded resting-state functional magnetic resonance imaging (fMRI) scans in twenty-three healthy volunteers after two week intake of the combined serotonin-norepinephrine reuptake inhibitor (SNRI) duloxetine in a double-blind, placebo-controlled, crossover study. Duloxetine improved mood in part as a result of increased resilience to the mood-worsening effects of scanning and reduced DMN and TPN connectivity. Within the DMN, duloxetine reduced connectivity between the medial prefrontal cortex (MPFC) and the lateral parietal cortex (LPC) and uncoupled the MPFC from the dorsolateral prefrontal cortex (DLPFC). Within the TPN, duloxetine uncoupled the intraparietal sulcus (IPS) from the inferior occipital gyrus. These results show that two-week antidepressant administration reduces DMN and TPN connectivity in healthy volunteers, which may contribute to their antidepressant effects in depression.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: guidovanwingen@gmail.com.
authors.forename: Guido A
authors.initials: GA
authors.lastname: van Wingen
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Faculty of Medicine and LVR Clinic for Psychiatry and Psychotherapy, University of Duisburg-Essen, Germany; Departments of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Indira
authors.initials: I
authors.lastname: Tendolkar
authors.affiliation: UCL Institute of Cognitive Neuroscience, London, UK; Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK.
authors.forename: Maren
authors.initials: M
authors.lastname: Urner
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Hein J
authors.initials: HJ
authors.lastname: van Marle
authors.affiliation: Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; The Netherlands Institute for Neuroscience, an Institute of The Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
authors.forename: Damiaan
authors.initials: D
authors.lastname: Denys
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Departments of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Robbert-Jan
authors.initials: RJ
authors.lastname: Verkes
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Guillén
authors.initials: G
authors.lastname: Fernández
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D063132:Connectome / Q000379:methods*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000074222:Rumination, Cognitive / Q000502:physiology; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D000068736:Duloxetine Hydrochloride
keywords: Antidepressant; Default mode; Resting-state; Rumination; Task-positive; fMRI