title: Fate of [(14)C]xanthotoxin (8-methoxypsoralen) in laying hens and a lactating goat.
abstract: The metabolism of xanthotoxin, a naturally occurring furanocoumarin photosensitizer, was studied in laying hens and a lactating goat treated with single oral doses equivalent to 10 mg xanthotoxin/kg of body weight. Within 48 h, essentially all of the administered radiocarbon was eliminated in the excreta of the laying hens, while in the goat 92% and 3% were excreted in the urine and feces, respectively. Radiocarbon residues in the milk, egg white, and egg yolk were low. Xanthotoxin, 8-hydroxypsoralen (xanthotoxol), 6-(7-hydroxy-8-methoxycoumaryl)-acetic acid (HCA) and 6-(7-hydroxy-8-methoxycoumaryl)-hydroxyacetic acid (HCHA) were identified in the excreta of laying hens. In the goat, xanthotoxin was metabolized to HCA, HCHA, xanthotoxol, 5,8-dihydroxypsoralen, psoralenquinone, 5-hydroxy-8-methoxy-psoralen and 3[5-(6-hydroxy-7-methoxybenzofuryl)]-propanoic acid. Thus, identified metabolites in one or both of these species arose throughO-demethylation, oxidative cleavage of the furan ring, hydroxylation, reduction, oxidation, and hydrolysis of the lactone ring.
authors.affiliation: Food Animal Protection Research Laboratory, USDA-ARS, College Station, 77845, Texas.
authors.forename: N C
authors.initials: NC
authors.lastname: Pangilinan
authors.forename: G W
authors.initials: GW
authors.lastname: Ivie
authors.forename: B A
authors.initials: BA
authors.lastname: Clement
authors.forename: R C
authors.initials: RC
authors.lastname: Beier
authors.forename: M
authors.initials: M
authors.lastname: Uwayjan