title: Oral mucosal injury caused by cancer therapies: current management and new frontiers in research.
abstract: This invited update is designed to provide a summary of the state-of-the-science regarding oral mucosal injury (oral mucositis) caused by conventional and emerging cancer therapies. Current modeling of oral mucositis pathobiology as well as evidence-based clinical practice guidelines for prevention and treatment of oral mucositis are presented. In addition, studies addressing oral mucositis as published in the Journal of Oral Pathology and Medicine 2008-2013 are specifically highlighted in this context. Key research directions in basic and translational science associated with mucosal toxicity caused by cancer therapies are also delineated as a basis for identifying pathobiologic and pharmacogenomic targets for interventions. This collective portfolio of research and its ongoing incorporation into clinical practice is setting the stage for the clinician in the future to predict mucosal toxicity risk and tailor therapeutic interventions to the individual oncology patient accordingly.
authors.affiliation: Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Siri B
authors.initials: SB
authors.lastname: Jensen
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Peterson
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects; D009061:Mouth Mucosa / Q000187:drug effects / Q000528:radiation effects; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D013280:Stomatitis / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents
keywords: cancer therapy; oral mucositis; pathobiology; prevention; research; treatment