title: Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury.
abstract: Spinal cord injury (SCI) often leads to persistent functional deficits due to the loss of neurons and glia and to limited axonal regeneration after such injury. Recently, three independent groups have reported marked recovery of hindlimb locomotor function after the transplantation of human adult dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) into rats or mice with acute, sub-acute or chronic SCI. This review summarizes the primary characteristics of human dental pulp stem cells and their therapeutic benefits for treating SCI. Experimental data from multiple preclinical studies suggest that pulp stem cells may promote functional recovery after SCI through multifaceted neuro-regenerative activities.
authors.affiliation: Department of Oral and Maxillofacial Surgery of Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: akihito@med.nagoya-u.ac.jp.
authors.forename: Akihito
authors.initials: A
authors.lastname: Yamamoto
authors.affiliation: Department of Oral and Maxillofacial Surgery of Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Oral and Maxillofacial Surgery of Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Kohki
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Oral and Maxillofacial Surgery of Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Fumiya
authors.initials: F
authors.lastname: Kano
authors.affiliation: Department of Oral and Maxillofacial Surgery of Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Ueda
mesh_terms: D000818:Animals; D003782:Dental Pulp / Q000166:cytology*; D006801:Humans; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D020127:Recovery of Function / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
keywords: Anti-apoptosis; Anti-inflammatory; Axonal regeneration; Cell-replacement activity; Dental pulp stem cells; Spinal cord injury