title: Synthesis, characterization and anti-proliferative activity of Cd(II) complexes with NNN type pyrazole-based ligand and pseudohalide ligands as coligand.
abstract: Cd(II) complexes of tridentate nitrogen donor ligand, 2,6-bis(3,4,5-trimethylpyrazolyl)pyridine (btmpp), Cd(btmpp)X2 (X:Cl, ONO or N(CN)2) have been synthesized and characterized by elemental and spectral (FT-IR, (1)H NMR, (13)C NMR, UV-Vis) analyses, differential thermal analysis and single crystal X-ray diffraction studies. The molecular structure of reported complex 1, revealed distorted square-pyramidal geometry around Cadmium. Complexes 1-3 and corresponding ligand were tested for cytotoxic activity against the human carcinoma cell lines HEP3B (hepatocellular carcinoma), PC3 (prostate adenocarcinoma), MCF7 (breast adenocarcinoma) and Saos2 (osteosarcoma). The results show that, complexes are more cytotoxic than the free ligand and complex 2 is the most cytotoxic complex for PC3.
authors.affiliation: University of Balikesir, Faculty of Science and Literature, Department of Chemistry, 10145 Balikesir, Turkey. Electronic address: cigdemhopa@gmail.com.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Hopa
authors.affiliation: University of Balikesir, Faculty of Science and Literature, Department of Biology, 10145 Balikesir, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Yildirim
authors.affiliation: University of Balikesir, Faculty of Science and Literature, Department of Physics, 10145 Balikesir, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Kara
authors.affiliation: Akdeniz University, Alanya Engineering Faculty, Materials Science and Engineering, 07425, Alanya, Antalya, Turkey.
authors.forename: Raif
authors.initials: R
authors.lastname: Kurtaran
authors.affiliation: University of Balikesir, Faculty of Science and Literature, Department of Chemistry, 10145 Balikesir, Turkey.
authors.forename: Mahir
authors.initials: M
authors.lastname: Alkan
mesh_terms: D002104:Cadmium / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004055:Differential Thermal Analysis; D004583:Electrons; D006219:Halogens / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D008024:Ligands; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014732:Vibration
chemical_list: D006219:Halogens; D008024:Ligands; D011720:Pyrazoles; D002104:Cadmium; C031280:pyrazole
keywords: Cadmium(II); Cytotoxicity; Dicyanamide; Nitrite; Pyrazole-pyridine ligand; X-ray structure