title: Reorganization of sensory pathways after neonatal hemidecortication in rats.
abstract: We investigated ascending somatosensory pathways in neonatally hemidecorticated rats. Injection of an anterograde tracer, biotinylated dextran amine (BDA), into the contralesional dorsal root ganglions revealed ipsilateral projections to the dorsal column nuclei (DCN) in hemidecorticated rats as well as in normal rats. Injection of BDA into the DCN on the same side revealed that while most axons projected to the contralateral thalamus, some axons were detected in the ipsilateral thalamus in hemidecorticated rats while such projections were rarely detected in normal rats. The results suggest that aberrant ipsilateral projections of DCN neurons contralateral to the lesion developed after the hemidecortication.
authors.affiliation: Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Myodaiji, Okazaki, Japan; Physiology Unit, Department of Medical Sciences, Faculty of Sciences, Rangsit University, Pathumthani, Thailand; Inter-disciplinary Program of Physiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Oraphan
authors.initials: O
authors.lastname: Wanakhachornkrai
authors.affiliation: Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Myodaiji, Okazaki, Japan. Electronic address: tumeda@yokohama-cu.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Umeda
authors.affiliation: Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Myodaiji, Okazaki, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Isa
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.
authors.forename: Mayuree H
authors.initials: MH
authors.lastname: Tantisira
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Faculty of Pharmacy, Silpakorn University, Nakhonpathom, Thailand.
authors.forename: Boonyong
authors.initials: B
authors.lastname: Tantisira
authors.affiliation: Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Myodaiji, Okazaki, Japan; School of Life Science, The Graduated University for Advanced Studies (SOKENDAI), Hayama, Japan; Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isa
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000166:cytology*; D005727:Ganglia, Spinal / Q000166:cytology*; D038421:Hemispherectomy; D009434:Neural Pathways; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000166:cytology*
keywords: Biotinylated dextran amine; Hemidecortication; Lemniscus pathway; Plasticity