title: Towards cytotoxic and selective derivatives of maslinic acid.
abstract: Several novel esters and amides of maslinic acid were prepared. Their evaluation for cytotoxic activity with a panel of human cancer cell lines using a sulforhodamine B (SRB) assay revealed for some of them a noteworthy activity. The results from annexinV-FITC and caspase-assays as well as from DNA laddering experiments provided evidence for an apoptotic cell death. A diacetylated benzylamide (15) induced a G1/G0 arrest in tumor cells. It also displayed an extraordinary cytotoxicity against human ovarian cancer cells but a 300 times lower toxicity for non-malignant primary human fibroblasts.
authors.affiliation: Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
authors.forename: Bianka
authors.initials: B
authors.lastname: Siewert
authors.affiliation: Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Pianowski
authors.affiliation: Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Obernauer
authors.affiliation: Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. Electronic address: rene.csuk@chemie.uni-halle.de.
authors.forename: René
authors.initials: R
authors.lastname: Csuk
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004952:Esters / Q000737:chemistry; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry*; D009828:Oleanolic Acid / Q000031:analogs & derivatives
chemical_list: D000577:Amides; D004952:Esters; D014315:Triterpenes; C412811:maslinic acid; D009828:Oleanolic Acid
keywords: Annexin V assay; Antitumor; Apoptosis; Cancer; Caspase activity; Cell cycle investigations; DNA laddering; Esters; Maslinic acid; SRB assay