title: Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: pilot randomised controlled trial.
abstract: A partial N-methyl-D-aspartate agonist, D-cycloserine, enhances fear extinction when given before or shortly after exposure to feared stimuli in animals. In this pilot double-blind placebo-controlled trial (trial number: ISRCTN70977225), 27 youth with obsessive-compulsive disorder were randomised to either 50 mg D-cycloserine or placebo administered immediately after each of ten cognitive-behavioural therapy (CBT) sessions, primarily consisting of exposure and ritual prevention. Both groups improved significantly and maintained their gains at 1-year follow-up, with no significant advantage of D-cycloserine over placebo at any time point. The effects of CBT may not be augmented or accelerated when D-cycloserine is administered after sessions.
authors.affiliation: David Mataix-Cols, PhD, Cynthia Turner, PhD, Benedetta Monzani, MSc, Kayoko Isomura, MD, PhD, Caroline Murphy, MSc, Georgina Krebs, DClinPsych, Isobel Heyman, MBBS, PhD, FRCPsych, King's College London, Institute of Psychiatry and OCD and Related Disorder Clinic for Young People, South London and Maudsley NHS Foundation Trust, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Mataix-Cols
authors.forename: Cynthia
authors.initials: C
authors.lastname: Turner
authors.forename: Benedetta
authors.initials: B
authors.lastname: Monzani
authors.forename: Kayoko
authors.initials: K
authors.lastname: Isomura
authors.forename: Caroline
authors.initials: C
authors.lastname: Murphy
authors.forename: Georgina
authors.initials: G
authors.lastname: Krebs
authors.forename: Isobel
authors.initials: I
authors.lastname: Heyman
mesh_terms: D000818:Animals; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003523:Cycloserine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005108:Extinction, Psychological / Q000187:drug effects*; D005239:Fear / Q000187:drug effects; D006801:Humans; D057194:Intention to Treat Analysis; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D010865:Pilot Projects; D010919:Placebos; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine