title: Lipid, protein and poly(NIPAM) coated mesoporous silica nanoparticles for biomedical applications.
abstract: In the past decade, mesoporous silica nanoparticles (MSNs) as nanocarriers have showed much potential in advanced nanomaterials due to their large surface area and pore volume. Especially, more and more MSNs based nanodevices have been designed as efficient drug delivery systems (DDSs) or biosensors. In this paper, lipid, protein and poly(NIPAM) coated MSNs are reviewed from the preparation, properties and their potential application. We also introduce the preparative methods including physical adsorption, covalent binding and self-assembly on the MSNs' surfaces. Furthermore, the interaction between the aimed cells and these molecular modified MSNs is discussed. We also demonstrate their typical applications, such as photodynamic therapy, bioimaging, controlled release and selective recognition in biomedical field.
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: yangyang@nanoctr.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, China; Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: jbli@iccas.ac.cn.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D020811:Biomedical Technology / Q000639:trends; D055598:Chemical Phenomena; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006801:Humans; D019044:Image Cytometry / Q000639:trends; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000639:trends; D011506:Proteins / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D011506:Proteins; C052970:poly-N-isopropylacrylamide; D012822:Silicon Dioxide
keywords: Biomedical application; Lipids; Mesoporous silica nanoparticles; Poly(NIPAM); Protein