title: Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function.
abstract: Peanut skin is a rich source of polyphenols including procyanidins and is shown to have hypolipidemic properties. This study investigated the bioavailability of peanut skin polyphenols using a rat model. First, the bioavailability of peanut skin polyphenols in rat plasma was evaluated. Our results showed procyanidin A2 levels in plasma peaked within 30 min of ingestion. The results of a second study show that peanut skin extract supplemented in addition to oil gavage resulted in significant decrease in plasma triglyceride and VLDL within 5h. In the third study, rats were given a Western type diet for 5 weeks with peanut skin extract at a dose of 150 and 300 mg/kg body weight. The main effects observed were lowering of total blood lipid and reduction of the plasma fatty acids profile. Our results suggest that procyanidin A may impart a key role of hypolipidemic effect seen in peanut skin polyphenols.
authors.affiliation: Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. Electronic address: rbansode@ncat.edu.
authors.forename: Rishipal R
authors.initials: RR
authors.lastname: Bansode
authors.forename: Priscilla
authors.initials: P
authors.lastname: Randolph
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ahmedna
authors.forename: Steven
authors.initials: S
authors.lastname: Hurley
authors.forename: Tracy
authors.initials: T
authors.lastname: Hanner
authors.forename: Sarah A Schwatrz
authors.initials: SA
authors.lastname: Baxter
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Johnston
authors.forename: Mingming
authors.initials: M
authors.lastname: Su
authors.forename: Bryce M
authors.initials: BM
authors.lastname: Holmes
authors.forename: Jianmei
authors.initials: J
authors.lastname: Yu
authors.forename: Leonard L
authors.initials: LL
authors.lastname: Williams
mesh_terms: D000818:Animals; D010367:Arachis / Q000737:chemistry*; D001682:Biological Availability; D005227:Fatty Acids / Q000097:blood; D000960:Hypolipidemic Agents / Q000097:blood / Q000493:pharmacokinetics*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D010936:Plant Extracts / Q000097:blood / Q000493:pharmacokinetics*; D059808:Polyphenols / Q000097:blood / Q000493:pharmacokinetics*; D044945:Proanthocyanidins / Q000097:blood / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D005227:Fatty Acids; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols; D044945:Proanthocyanidins; D014280:Triglycerides
keywords: Flavanoids; Hypolipidemia; Peanut skin; Polyphenols; Procyanidins