title: In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease.
abstract: BACKGROUND
  This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies.
  
  
  METHODS
  In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations.
  
  
  CONCLUSIONS
  The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei--particularly the putamen--as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies.
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors.forename: Julio
authors.initials: J
authors.lastname: Acosta-Cabronero
authors.forename: Guy B
authors.initials: GB
authors.lastname: Williams
authors.forename: Arturo
authors.initials: A
authors.lastname: Cardenas-Blanco
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Arnold
authors.forename: Victoria
authors.initials: V
authors.lastname: Lupson
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nestor
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015203:Reproducibility of Results