title: Retrospective study of salazosulfapyridine in eight patients with rheumatoid arthritis on hemodialysis.
abstract: OBJECTIVE
  We examined the pharmacokinetics (PK) of salazosulfapyridine (SASP) and its metabolite, sulfapyridine (SP), as well as the influence of hemodialysis (HD), and investigated the utility of consecutive administration of SASP in rheumatoid arthritis patients undergoing HD.
  
  
  METHODS
  The PK of salazosulfapyridine and SP in serum samples from 8 patients was determined using high-performance liquid chromatography.
  
  
  RESULTS
  When SASP 500 mg was administered, the area under curve for serum concentration of SASP was similar to that seen with normal subjects in the Phase I study. The maximum serum concentration of SP was significantly higher than that in normal subjects, but was far from the danger level. SASP was not dialyzed, whereas on average 62% of SP was dialyzed. Following 5 consecutive days of administration of SASP, serum levels of SASP and SP on day 5 were rather higher than those on day 1, although both remained within the safe range. SASP administration from four months to three years in seven subjects resulted in four American College of Rheumatology 20 improvement criteria (57.1%), with one developing a rash.
  
  
  CONCLUSIONS
  If SASP is initiated at a low dosage (≤ 500 mg) and increased up to 1000 mg under careful monitoring, it is safe for HD patients.
authors.affiliation: Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University , Saitama , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Yusei
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Eiichi
authors.initials: E
authors.lastname: Furuta
authors.forename: Toshihide
authors.initials: T
authors.lastname: Mimura
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012189:Retrospective Studies; D012460:Sulfasalazine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: C009943:salazodin; D012460:Sulfasalazine