title: [Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.
  
  
  METHODS
  CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.
  
  
  RESULTS
  Up-regulated CIP2A expression was closely related with TNM staging, histological type, peritoneal seeding and liver metastasis (all P<0.05), but not related with gender, age, tumor location, CEA, family history and grade of differentiation. Overall survival rates of 1-, 3-, 5-, and 10-year in high CIP2A expression group were 97.1%, 71.4%, 59.2%, and 44.4% respectively, significantly lower than 98.2%, 85.7%, 80.3%, and 74.9% in low CIP2A expression group(P=0.021). Multivariate analysis showed that CIP2A was not an independent factor associated with prognosis(P=0.099, HR=1.982, 95%CI:0.879 to 4.469).
  
  
  CONCLUSIONS
  Up-regulated CIP2A expression is closely related to clinicopathology of colorectal cancer. CIP2A may be used as a potential predictive marker of metastasis, prognosis and therapeutic target in colorectal cancer.
authors.affiliation: Department of General Surgery, Jiangxi People's Hospital, Nanchang 330006, China. qlzkz@163.com.
authors.forename: Xing-yu
authors.initials: XY
authors.lastname: Peng
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Fu
authors.forename: Qing-li
authors.initials: QL
authors.lastname: Zeng
mesh_terms: D001324:Autoantigens; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms; D008565:Membrane Proteins; D009367:Neoplasm Staging; D011379:Prognosis; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: D001324:Autoantigens; D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D054648:Protein Phosphatase 2