title: Hepatoprotective Effect of Otostegia persica Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats.
abstract: In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract of O. persica shoot (in 200, 300, 400 mg/Kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (MDA), transaminase enzyme levels in plasma [aspartate transaminase (AST), alanine aminotransferase (ALT)] and liver glutathione (GSH) levels). Results show that the methanol extract of O. persica shoot is active at 300 mg/Kg (per os) and it possess remarkable antioxidant and hepatoprotective activities. Additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention.
authors.affiliation: Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
authors.forename: Sedighe
authors.initials: S
authors.lastname: Nasiri Bezenjani
authors.forename: Iran
authors.initials: I
authors.lastname: Pouraboli
authors.forename: Reza
authors.initials: R
authors.lastname: Malekpour Afshar
authors.forename: Gholamabbas
authors.initials: G
authors.lastname: Mohammadi
keywords: Carbon tetrachloride; GSH; Hepatoprotective; Histopathology; MDA; Otostegia persica