title: Intrinsic coupling modes: multiscale interactions in ongoing brain activity.
abstract: Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich spatiotemporal patterning and contains information that influences cognitive processing. We discuss evidence for two distinct types of intrinsic coupling modes which seem to reflect the operation of different coupling mechanisms. One type arises from phase coupling of band-limited oscillatory signals, whereas the other results from coupled aperiodic fluctuations of signal envelopes. The two coupling modes differ in their dynamics, their origins, and their putative functions and with respect to their alteration in neuropsychiatric disorders. We propose that the concept of intrinsic coupling modes can provide a unifying framework for capturing the dynamics of intrinsically generated neuronal interactions at multiple spatial and temporal scales.
authors.affiliation: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: ak.engel@uke.de.
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Engel
authors.forename: Christian
authors.initials: C
authors.lastname: Gerloff
authors.forename: Claus C
authors.initials: CC
authors.lastname: Hilgetag
authors.forename: Guido
authors.initials: G
authors.lastname: Nolte
mesh_terms: D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D003198:Computer Simulation; D004569:Electroencephalography; D055724:Electrophysiological Phenomena; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological