title: miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF.
abstract: miR-141 belongs to the miR-200 family, and has been found to be associated with numerous human malignancies; however, its role in gastric cancer (GC) has not been examined in detail. Here, we validated that miR-141 was decreased in GC tissues and cell lines. Forced expression of miR-141 significantly repressed GC cell proliferation and colony formation. Furthermore, miR-141 suppressed in vitro migration and invasion of GC cells. Hepatoma-derived growth factor (HDGF) was confirmed to be a direct target of miR-141 in GC cells. The suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. Moreover, the expression of HDGF was negatively correlated with miR-141 in GC tissues. Our data suggest that miR-141 might be associated and plays essential role in GC progression.
authors.affiliation: Department of Gastroenterology, The No.1 People's Hospital of Jingmen, Jingmen, 448000, China.
authors.forename: Bitao
authors.initials: B
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Lv
authors.forename: Hongxing
authors.initials: H
authors.lastname: Li
authors.forename: Shitao
authors.initials: S
authors.lastname: Xia
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors*; D013274:Stomach Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D036341:Intercellular Signaling Peptides and Proteins; C533895:MIRN141 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; C051610:hepatoma-derived growth factor