title: Dynein, microtubule and cargo: a ménage à trois.
abstract: To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.
authors.affiliation: *Department of Physics, Faculty of Science, University of Zagreb, 10002 Zagreb, Croatia.
authors.forename: Nenad
authors.initials: N
authors.lastname: Pavin
authors.forename: Iva M
authors.initials: IM
authors.lastname: Tolić-Nørrelykke
mesh_terms: D004398:Dyneins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism
chemical_list: D004398:Dyneins