title: [Bioinformatics analysis and identification of transcriptional regulation of human UCA1 gene].
abstract: OBJECTIVE
  To analyze the transcription factor binding sites and methylation in the promoter region of UCA1 gene.
  
  
  METHODS
  UCA1 gene promoter was analyzed using CpG software to predict the CpG island. MatrixCatch and TFSEARCH were used to predict the potential transcription factor binding sites in UCA1 gene core promoter. ChIP assay was used to identify the transcription factors binding to UCA1 gene core promoter.
  
  
  RESULTS
  UCA1 gene promoter contained no CpG island and was therefore a typical tissue-specific gene. There were 4 transcription factors associated with human cancers in UCA1 gene core promoter, but only one of them interacted with UCA1 gene core promoter.
  
  
  CONCLUSIONS
  There is no CpG island in UCA1 gene promoter region, and the transcription factor c-Myb can specifically bind to the core promoter.
authors.affiliation: Center for Translational Medicine, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, China.E-mail: xuemei1984-@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D001665:Binding Sites / Q000235:genetics; D045744:Cell Line, Tumor; D019295:Computational Biology; D018899:CpG Islands / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics; D019175:DNA Methylation; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics*; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics*; D012984:Software; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D020598:Proto-Oncogene Proteins c-myb; D062085:RNA, Long Noncoding; C515159:UCA1 RNA, human