title: Activity of ceftolozane-tazobactam against a broad spectrum of recent clinical anaerobic isolates.
abstract: We evaluated in vitro activity of ceftolozane-tazobactam (TOL-TAZ), formerly CXA-201, against recent clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. Ceftolozane-tazobactam showed good activity against B. fragilis species and intermediate to limited activity against other species of Bacteroides. Ceftolozane-tazobactam showed very good activity against Prevotella spp., Fusobacterium spp., and Propionibacterium spp., varying activities against Gram-positive cocci, and limited activity against Clostridium spp.
authors.affiliation: Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Snydman
authors.forename: Laura A
authors.initials: LA
authors.lastname: McDermott
authors.forename: Nilda V
authors.initials: NV
authors.lastname: Jacobus
mesh_terms: D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002511:Cephalosporins / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D004338:Drug Combinations; D005673:Fusobacterium / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D018720:Prevotella / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D011424:Propionibacterium / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; C519491:ceftolozane; D010397:Penicillanic Acid; D000078142:Tazobactam