title: Simulation of interstitial fluid flow in ligaments: comparison among Stokes, Brinkman and Darcy models.
abstract: In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation well in high hydraulic permeability (k p) condition (k p ≥1.0×10(-8) m(2) in our numerical simulation), and it is an approximation to Darcy model in low k p condition (k p ≤5.0×10(-12) m(2) in our numerical simulation), we used the Brinkman model to simulate the interstitial fluid flow in the ligament where k p is approximately 1.0×10(-16) m(2). It shows k p and anisotropic property have a little effect on the flow field, but have a great effect on the shear stress on the membrane of interstitial cells (τ cell). There is a linear relationship between τ cell and , when k p =1.0×10(-16) m(2) and the maximum τ cell (τ cell,max) is approximately 10 Pa. The anisotropic property will affect τ cell's distribution on the cell surface. When k x/k y>1, low τ cell dominates the cell, while when k x/k y<1, high τ cell dominants the cell.
authors.affiliation: Department of Mechanics and Engineering Science, Fudan University, Shanghai Research Center of Acupuncture, Shanghai, 200433.
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.forename: Zhoufeng
authors.initials: Z
authors.lastname: Shen
authors.forename: Guanghong
authors.initials: G
authors.lastname: Ding
mesh_terms: D045604:Extracellular Fluid / Q000502:physiology*; D008022:Ligaments / Q000502:physiology*; D008407:Mast Cells / Q000648:ultrastructure; D008854:Microscopy, Electron; D008954:Models, Biological; D010539:Permeability
keywords: Interstitial fluid flow; anisotropy.; numerical simulation; porous media; sheer stress