title: [Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].
abstract: METHODS
  A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study. Systemic corticosteroids and cyclosporine were initiated unsuccessfully; therefore intra-lesional injections of triamcinolone were started, which controlled the orbital disease.
  
  
  CONCLUSIONS
  Necrobiotic xanthogranuloma is a rare condition that usually affects the eyelids and anterior orbit. Its diagnosis is important as it is associated with malignant lymphoproliferative processes. Intra-lesional corticosteroids were effective in our patient.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España. Electronic address: empar19@hotmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Sanz-Marco
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España; Facultad de Óptica, Universidad de Valencia, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: España
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: López-Prats
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Chirivella-Casanova
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España.
authors.forename: J
authors.initials: J
authors.lastname: Aviño
authors.affiliation: Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España; Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, España; Centro de Investigación de Enfermedades Raras (CIBERER), Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Llopis
mesh_terms: D003937:Diagnosis, Differential; D049670:History, 17th Century; D006801:Humans; D008297:Male; D058252:Necrobiotic Xanthogranuloma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
keywords: Corticoides; Corticosteroids; Gammapatía monoclonal; Monoclonal gammapathy; Necrobiotic xanthogranuloma; Xanthogranuloma; Xanthogranulomatosis; Xantogranuloma; Xantogranuloma necrobiótico; Xantogranulomatosis