title: The relationship between serum tumor-associated trypsin inhibitor levels and clinicopathological parameters in patients with gastric cancer.
abstract: BACKGROUND
  Tumor-associated trypsin inhibitor (TATI) is expressed with trypsinogen in tumors. We studied the clinical-pathologic association and significance of preoperative serum levels of TATI in gastric cancer patients.
  
  
  METHODS
  Pre-treatment serum levels of TATI in patients with gastric cancer and healthy controls were analyzed by a specific enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Statistically significant differences were found in serum TATI levels between patients with gastric cancer and healthy controls (p < 0.0001). There was a significant relationship between the serum levels of TATI and clinicopathological parameters. However, serum levels of TATI were significantly higher in patients with an advanced T stage (T3) (p < 0.001), lymph node metastasis (p < 0.001) and an advanced TNM stage (stage III or IV; p < 0.001).
  
  
  CONCLUSIONS
  Our study suggests that TATI may be used to identify potentially high-risk groups of upper gastric carcinoma. Elevated level of TATI was associated with progressive disease or advanced stage.
authors.affiliation: Department of General Surgery, School of Medicine, University of Yuzuncu Yil, Van, Turkey. ozgurkemik@hotmail.com  
authors.forename: O
authors.initials: O
authors.lastname: Kemik
authors.forename: A
authors.initials: A
authors.lastname: Kemik
authors.forename: A
authors.initials: A
authors.lastname: Sümer
authors.forename: N
authors.initials: N
authors.lastname: Almali
authors.forename: E
authors.initials: E
authors.lastname: Gurluler
authors.forename: N
authors.initials: N
authors.lastname: Gures
authors.forename: S
authors.initials: S
authors.lastname: Purisa
authors.forename: G
authors.initials: G
authors.lastname: Adas
authors.forename: Y
authors.initials: Y
authors.lastname: Dogan
authors.forename: S
authors.initials: S
authors.lastname: Tuzun
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000473:pathology*; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood*
chemical_list: D014359:Trypsin Inhibitor, Kazal Pancreatic