title: Increased N-terminal CgA in circulation associated with cardiac reperfusion in pigs.
abstract: OBJECTIVE
  Acute myocardial infarction causes neurohumoral activation characterized by increased sympathetic activity. CgA is a protein released during sympathoadrenal stress from neuroendocrine tissue. Recently, increased CgA concentrations in circulation have been reported and suggested to be an independent predictor of mortality after acute myocardial infarction.
  
  
  METHODS
  Eighteen pigs underwent 1 h of regional myocardial ischemia followed by 3 h of reperfusion. Blood samples were collected every hour and plasma CgA was measured with two radioimmunoassays.
  
  
  RESULTS
  We found a 30% increase in plasma N-terminal CgA 1 h after re-establishment of coronary blood supply. On the other hand, plasma pancreastatin did not change in response to ischemia or reperfusion but decreased during the entire experiment.
  
  
  CONCLUSIONS
  Our results suggest a differentiated CgA response in myocardial reperfusion after local cardiac anoxia that may reflect tissue-specific post-translational processing and release.
authors.affiliation: Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Frydland
authors.forename: Birgitte
authors.initials: B
authors.lastname: Kousholt
authors.forename: Jens Rolighed
authors.initials: JR
authors.lastname: Larsen
authors.forename: John C
authors.initials: JC
authors.lastname: Burnettr
authors.forename: Linda
authors.initials: L
authors.lastname: Hilsted
authors.forename: J Michael
authors.initials: JM
authors.lastname: Hasenkam
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Goetze
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D053379:Chromogranin A / Q000097:blood* / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics; D017202:Myocardial Ischemia / Q000097:blood / Q000473:pathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D045265:Natriuretic Peptides / Q000627:therapeutic use; D010187:Pancreatic Hormones / Q000032:analysis / Q000097:blood; D010455:Peptides / Q000032:analysis / Q000097:blood* / Q000737:chemistry; D013552:Swine; D013997:Time Factors; D020107:Troponin T / Q000097:blood
chemical_list: D053379:Chromogranin A; D045265:Natriuretic Peptides; D010187:Pancreatic Hormones; D010455:Peptides; D020107:Troponin T; C050836:pancreastatin