title: Congenital infantile fibrosarcoma: Association with bleeding diathesis.
abstract: METHODS
  Male, 2 month
  
  
  METHODS
  Congenital infantile fibrosarcoma Symptoms: Bleeding Medication: Vincristine • actinomycin • cyclophosphamide Clinical Procedure: Surgical resection Specialty: Pediatric Oncology.
  
  
  OBJECTIVE
  Diagnostic/therapeutic accidents.
  
  
  BACKGROUND
  Congenital infantile fibrosarcoma (CIF) is a soft-tissue tumor occurring during the first 2 years of life, most commonly in the extremities. CIF is frequently initially misdiagnosed as a vascular tumor, but its association with bleeding and coagulopathy has not been well characterized.
  
  
  METHODS
  We describe 2 infants with CIF presenting with bleeding and coagulopathy, requiring urgent intervention. Both patients did well; one underwent partial resection followed by chemotherapy, and the other received 2 cycles of chemotherapy followed by gross total resection. We also provide a review of all reported cases of coagulopathy in the setting of CIF in the English literature, uncovering an association that seems to be more prevalent in patients diagnosed in the neonatal period, with associated anemia and thrombocytopenia, and a significant mortality rate.
  
  
  CONCLUSIONS
  CIF needs to be considered in the differential diagnosis of vascular congenital tumors, especially when there is evidence of bleeding, anemia, or thrombocytopenia.
authors.affiliation: Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Mayssaa
authors.initials: M
authors.lastname: Salman
authors.forename: Nabil J
authors.initials: NJ
authors.lastname: Khoury
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Khalifeh
authors.forename: Hussein A
authors.initials: HA
authors.lastname: Abbas
authors.forename: Marianne
authors.initials: M
authors.lastname: Majdalani
authors.forename: Miguel
authors.initials: M
authors.lastname: Abboud
authors.forename: Samar
authors.initials: S
authors.lastname: Muwakkit
authors.forename: Hassan El
authors.initials: HE
authors.lastname: Solh
authors.forename: Raya
authors.initials: R
authors.lastname: Saab
keywords: bleeding; congenital infantile fibrosarcoma; vascular tumor