title: (18)F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma.
abstract: Functional imaging plays a crucial role in the assessment of neuroblastoma. The evaluation of response to induction chemotherapy is a cornerstone in scheduling proper treatment management in patients affected by high-risk neuroblastoma. (123)I-metaiodobenzylguanidine has been recognized as the radiopharmaceutical of choice in neuroblastoma assessment. To date, the clinical role of PET/CT in pediatric malignancy is not well established.(18)F-DOPA-PET/CT has been recently used in neuroblastoma, and compared with (123)I-MIBG-scan. Scant new data are available about the role of this tool in the evaluation of treatment response after induction chemotherapy. We investigate the role of (18)F-DOPA-PET/CT in characterizing the response to induction chemotherapy in a child affected by high-risk-neuroblastoma, in whom the rare association of (123)I-MIBG-negative primary tumor and MIBG-positive bone marrow metastases was observed.
authors.affiliation: Nuclear Medicine Unit, Galliera Hospital, Genoa, Italy, arnoldo.piccardo@galliera.it.
authors.forename: Arnoldo
authors.initials: A
authors.lastname: Piccardo
authors.forename: Egesta
authors.initials: E
authors.lastname: Lopci
authors.forename: Luca
authors.initials: L
authors.lastname: Foppiani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Morana
authors.forename: Massimo
authors.initials: M
authors.lastname: Conte
mesh_terms: D019046:Bone Marrow Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D002675:Child, Preschool; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D064847:Multimodal Imaging / Q000379:methods; D009447:Neuroblastoma / Q000175:diagnosis* / Q000188:drug therapy*; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine