title: Controlled trifluoromethylation reactions of alkynes through visible-light photoredox catalysis.
abstract: The control of a reaction that can form multiple products is a highly attractive and challenging concept in synthetic chemistry. A set of valuable CF3 -containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, and alkynes, were selectively generated from alkynes and CF3 I by environmentally benign and efficient visible-light photoredox catalysis. Subtle differences in the combination of catalyst, base, and solvent enabled the control of reactivity and selectivity for the reaction between an alkyne and CF3 I.
authors.affiliation: Department of Chemistry and Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu Ansan, Kyeonggi-do 426-791 (Republic of Korea).
authors.forename: Naeem
authors.initials: N
authors.lastname: Iqbal
authors.forename: Jaehun
authors.initials: J
authors.lastname: Jung
authors.forename: Sehyun
authors.initials: S
authors.lastname: Park
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Cho
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis / Q000737:chemistry; D008027:Light; D008745:Methylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010777:Photochemistry
chemical_list: D000475:Alkenes; D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D006847:Hydrocarbons, Iodinated
keywords: iridium; radical reactions; ruthenium; trifluoromethylation; visible light