title: Learning by aggregating experts and filtering novices: a solution to crowdsourcing problems in bioinformatics.
abstract: BACKGROUND
  In many biomedical applications, there is a need for developing classification models based on noisy annotations. Recently, various methods addressed this scenario by relaying on unreliable annotations obtained from multiple sources.
  
  
  RESULTS
  We proposed a probabilistic classification algorithm based on labels obtained by multiple noisy annotators. The new algorithm is capable of eliminating annotations provided by novice labellers and of providing a more accurate estimate of the ground truth by consensus labelling according to higher quality annotations. The approach is evaluated on text classification and prediction of protein disorder. Our study suggests that the higher levels of accuracy, effectiveness and performance can be achieved by the new method as compared to alternatives.
  
  
  CONCLUSIONS
  The proposed method is applicable for meta-learning from multiple existing classification models and noisy annotations obtained by humans. It is particularly beneficial when many annotations are obtained by novice labellers. In addition, the proposed method can provide further characterization of each annotator that can help in developing more accurate classifiers by identifying the most competent annotators for each data instance.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Weidan
authors.initials: W
authors.lastname: Cao
authors.forename: Zoran
authors.initials: Z
authors.lastname: Obradovic
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D063045:Crowdsourcing; D016015:Logistic Models; D011506:Proteins / Q000737:chemistry* / Q000145:classification*
chemical_list: D011506:Proteins