title: Retinal thinning and correlation with functional disability in patients with Parkinson's disease.
abstract: OBJECTIVE
  To determine whether there is an association between retinal thinning and functional rating scales in patients with Parkinson's disease (PD).
  
  
  METHODS
  Patients with PD (n=153) and controls (n=242) underwent evaluations of the macula and retinal nerve fibre layer (RNFL) using two new-generation Fourier domain optical coherence tomography (OCT) devices (Cirrus, Carl Zeiss Meditec, Dublin, California, USA; Spectralis, Heidelberg Engineering, Heidelberg, Germany). PD severity was assessed using the Schwab-England Activities of Daily Living scale, the Unified Parkinson Disease Rating Scale, the Hoehn and Yahr (HY) scale. Retinal and RNFL thicknesses were compared between patients and controls. Correlations between structural parameters and the scores of the neurologic scales were evaluated.
  
  
  RESULTS
  RNFL parameters were significantly reduced in patients with PD, especially when using the Spectralis OCT device. All macular parameters, except for foveal thickness, differed significantly between controls and patients with PD (p<0.001). HY scores were significantly and inversely correlated with all macular parameters when measured with the Spectralis OCT device (p<0.05) and with RNFL thickness when measured with the Cirrus OCT device (nasal quadrant, sectors 2 and 5).
  
  
  CONCLUSIONS
  The neurodegeneration caused by PD can be detected using Fourier domain OCT. RNFL and macular thicknesses correlate with PD severity.
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, , Zaragoza, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Satue
authors.forename: M
authors.initials: M
authors.lastname: Seral
authors.forename: S
authors.initials: S
authors.lastname: Otin
authors.forename: R
authors.initials: R
authors.lastname: Alarcia
authors.forename: R
authors.initials: R
authors.lastname: Herrero
authors.forename: M P
authors.initials: MP
authors.lastname: Bambo
authors.forename: M I
authors.initials: MI
authors.lastname: Fuertes
authors.forename: L E
authors.initials: LE
authors.lastname: Pablo
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Martin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D012162:Retinal Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
keywords: Optic Nerve; Pathology; Retina