title: Cutaneous Chromoblastomycosis Mimicking Tuberculosis Verrucosa Cutis: Look for Copper Pennies!
abstract: Chromoblastomycosis is a rare chronic fungal infection of skin and subcutaneous tissue. It is primarily a disease of tropical and subtropical regions and affects mainly the agricultural workers following trauma with vegetable matter. Cutaneous Chromoblastomycosis may clinically mimic cutaneous tuberculosis as both the condition usually presents with hyper pigmented verrucous lesion of skin. Here in we report a case of chronic cutaneous Chromoblastomycosis in a middle aged woman from north eastern part of India, who was initially misdiagnosed as Tuberculosis verrucosa cutis. In histopathology characteristic brown colored spores of the fungus (also known as copper pennies) were seen within dermal abscess. The organism isolated from culture of the biopsy material was Fonsecaea pedrosoi thus confirming our diagnosis of cutaneous chromoblastomycosis. The patient responded well to oral Itraconazole. The dermatologists and pathologists should be aware of this condition especially when dealing with verrucous lesion of the skin. The pathologists should search for fungal spores in cutaneous lesion with pseudoepitheliomatous hyperplasia and dermal abscess.
authors.affiliation: Department of Pathology, North Bengal Medical College, WEST BENGAL, INDIA.
authors.forename: Arghya
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Kaushik
authors.initials: K
authors.lastname: Majumdar
authors.forename: Mimi
authors.initials: M
authors.lastname: Gangopadhyay
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D001203:Ascomycota / Q000737:chemistry* / Q000187:drug effects / Q000302:isolation & purification; D001706:Biopsy; D002862:Chromoblastomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008543:Melanins / Q000032:analysis*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012867:Skin / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D013172:Spores, Fungal / Q000737:chemistry; D016896:Treatment Outcome; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000382:microbiology; D014860:Warts / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D008543:Melanins; D017964:Itraconazole