title: The emerging role of the receptor for advanced glycation end products on innate immunity.
abstract: Cells from innate immune system are activated by the engagement of germ-line encoded pattern-recognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of highly conserved microbial components called pathogen-associated molecular patterns or endogenous danger-associated molecular patterns. These danger signals are recognized by different types of (PRRs), including the receptor for advanced glycation end products. This new PRR share both ligands and intracellular signaling with Toll-like receptors and thus may cooperate with each other as essential partners to strength inflammatory response. This review summarizes recent advances in understanding the promiscuity of this receptor as well as its role in the context of innate immunity by triggering an inflammatory response when innate immune cells detect infection or tissue injury.
authors.affiliation: Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors.forename: Armando
authors.initials: A
authors.lastname: Rojas
authors.forename: Ramón
authors.initials: R
authors.lastname: Pérez-Castro
authors.forename: Ileana
authors.initials: I
authors.lastname: González
authors.forename: Fernando
authors.initials: F
authors.lastname: Delgado
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Romero
authors.forename: Israel
authors.initials: I
authors.lastname: Rojas
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition