title: Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry.
abstract: OBJECTIVE
  The findings of recent clinical trials suggest that treatment with high-dose statins reduces the risk of stroke recurrence. However, the doses approved in Japan are much lower than those in the previous studies. This study aimed to elucidate whether prescribed doses of statins reduce the risks of cerebrovascular events (CVEs: stroke recurrence or transient ischemic attack) and all-cause mortality in a cohort of Japanese patients with first-ever ischemic stroke.
  
  
  METHODS
  The 2822 eligible patients registered in the Fukuoka Stroke Registry with first-ever acute ischemic stroke from June 2007 to February 2011 were classified into statin users (n = 993) and non-users (n = 1829) at discharge, and followed up until March 2012. We assessed the cumulative risks of CVE and all-cause mortality by the Kaplan-Meier method, and calculated hazard ratios (HRs) and 95% confidential intervals (CIs) using the Cox proportional hazards model.
  
  
  RESULTS
  During the follow-up time (median, 2.0 years), 305 patients had CVEs and 345 died. The cumulative risks of CVE and death after 4 years were significantly lower in statin users than in non-users (13.8% versus 19.5%, P = 0.005 for CVE; 11.8% versus 21.7%, P < 0.001 for death). After adjusting for multiple confounding factors, statin treatment significantly reduced the risks of CVE (HR, 0.70; 95% CI, 0.53 to 0.92; P = 0.011) and all-cause mortality (HR, 0.67; 95% CI, 0.50 to 0.89; P = 0.006).
  
  
  CONCLUSIONS
  Our findings suggest that low-dose statin may reduce the risks of CVE and death in Japanese patients with acute ischemic stroke.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Makihara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamouchi
authors.forename: Jun
authors.initials: J
authors.lastname: Hata
authors.forename: Ryu
authors.initials: R
authors.lastname: Matsuo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kuwashiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugimori
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006761:Hospitals; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007511:Ischemia / Q000517:prevention & control* / Q000628:therapy; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012306:Risk; D055502:Secondary Prevention; D020521:Stroke / Q000188:drug therapy / Q000401:mortality* / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Ischemic stroke; Mortality; Recurrent event; Statin