title: The expanded role of extracellular matrix patch in malignant and non-malignant chest wall reconstruction in thoracic surgery.
abstract: OBJECTIVE
  The extracellular matrix (XCM Biologic Tissue Matrix) is a non-cross-linked 3D patch derived from porcine dermis. Once implanted, it is infiltrated by recipient's cells and becomes incorporated in the repair. Here, we report the first series of using this device for chest wall reconstruction.
  
  
  METHODS
  The XCM Biologic Tissue Matrix was utilized to provide the restoration of chest wall defects. It was used either alone or in conjunction with the Synthes titanium system to provide additional support. The decision was made intraoperatively.
  
  
  RESULTS
  Since April 2010, 21 (12 females) patients received the device. Average age at operation was 47 ± 17 years. Eleven (52%) patients had the patch inserted alone, while the remaining 10 received it in combination with another implantable medical device. The biological tissue matrix was used to reconstruct chest wall defects in cancer involving chest wall (n = 9), chest wall deformity (n = 6), chest wall hernia (n = 5) and chest wall repair following empyema drainage (n = 1). Complications were witnessed in 3 patients receiving the combined XCM and Synthes bar mechanisms; infection (n = 2) and bar displacement and infection (n = 1).
  
  
  CONCLUSIONS
  The XCM patch can be safely used to provide the strength required for chest wall reconstruction and to replace previously infected reconstructions.
authors.affiliation: Department of Thoracic Surgery, St James's University Hospital, Leeds Teaching Hospitals, Leeds, UK.
authors.forename: Robert S
authors.initials: RS
authors.lastname: George
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostopanagiotou
authors.forename: Kostas
authors.initials: K
authors.lastname: Papagiannopoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005109:Extracellular Matrix / Q000637:transplantation*; D005260:Female; D064593:Heterografts; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000295:instrumentation*; D013552:Swine; D019616:Thoracic Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D035441:Thoracic Wall / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D054457:Tissue Scaffolds; D016896:Treatment Outcome; D014945:Wound Healing
keywords: Biological tissue matrix; Chest wall; Synthes; XCM