title: [Clinical analysis of 29 cases with neuroendocrine neoplasm in the digestive system].
abstract: OBJECTIVE
  To investigate the diagnosis and treatment of neuroendocrine neoplasm (NEN) in the digestive system.
  
  
  METHODS
  Clinical data of 29 patients with NEN from January 2000 to December 2012 in The First Affiliated Hospital of Dalian Medical University were analyzed retrospectively and the prognosis was evaluated according to the new WHO classification.
  
  
  RESULTS
  There were 19 males and 10 females and the average age was 46.5 years. All the patients had no clinical manifestations of carcinoid syndrome, and they all received surgical treatment. Two cases were gastric neuroendocrine carcinoma(NEC), who received radical total gastrectomy and distal gastric resection respectively. Three cases had neoplasm in the duodenum, including 2 NEC and 1 neuroendocrine tumor(NET), and they all underwent Whipple's procedure. Two cases were small intestine NEC, who received partial small intestine resection. Three cases had neoplasm in the appendix, including 1 NEC treated with right hemicolectomy and 2 NET with appendectomy. One case was ascending colon NEC, who received right hemicolectomy. Eighteen cases had neoplasm in the rectum, including 4 NEC treated with low anterior resection and abdominoperineal resection respectively, and 14 cases of NET underwent low anterior resection, local resection, and endoscopic resection respectively. The 1- and 3- year survival rates of 13 NEC cases were 38.4% and 7.7% respectively. The 5-year survival rate of 16 NET cases was 81.3%.
  
  
  CONCLUSIONS
  NEN of digestive system is located mainly in the rectum and the clinical symptom is unspecific. Radical resection of NEN is the preferred treatment. The prognosis of NEC is poor, and that of NET is better.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China. surgerydoctor@sina.com.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Jun-qiang
authors.initials: JQ
authors.lastname: Li
authors.forename: Da-yu
authors.initials: DY
authors.lastname: Tian
authors.forename: Xun-guo
authors.initials: XG
authors.lastname: Yin
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Ge
authors.initials: G
authors.lastname: Liu
authors.forename: Pin
authors.initials: P
authors.lastname: Liang
authors.forename: Yun-qing
authors.initials: YQ
authors.lastname: Bai
authors.forename: Zhong-yi
authors.initials: ZY
authors.lastname: Shen
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
mesh_terms: D013505:Digestive System Surgical Procedures; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate