title: A case of phrynoderma in a patient with Crohn's disease.
abstract: Phrynoderma is a type of follicular hyperkeratosis associated with nutritional deficiencies. It is rarely seen in developed countries, although cases have been reported in patients with severe malnutrition or malabsorption secondary to various causes. This report describes a 19-year-old patient with poorly controlled Crohn's disease and malnutrition who developed the characteristic hyperkeratotic papules and plaques on his trunk and extremities in the setting of low serum vitamin A levels. To our knowledge, there are no reports of phrynoderma associated with Crohn's disease. It is likely that our patient's low vitamin A level and subsequent phrynoderma was the result of increased Crohn's disease activity and malnutrition.
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cobos
authors.forename: Christine
authors.initials: C
authors.lastname: Cornejo
authors.forename: Patrick
authors.initials: P
authors.lastname: McMahon
mesh_terms: D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D007644:Darier Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D044342:Malnutrition / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D035583:Rare Diseases; D018570:Risk Assessment; D014802:Vitamin A Deficiency / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D055815:Young Adult