title: Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite.
abstract: Primaquine (I), a 6-methoxy-8-aminoqumoline derivative used for the treatment of malaria has previously been shown to be metabolized to 8-(3-carboxy-l-methyl-propylamino)-6-methoxyquinoline by both micro-organisms and laboratory rats. Reported herein is the synthesis of this novel metabolite.
authors.affiliation: The Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, 38677.
authors.forename: J D
authors.initials: JD
authors.lastname: McChesney
authors.forename: S
authors.initials: S
authors.lastname: Sarangan