title: Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol.
abstract: Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6 mg/m(2)/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow-up. Sirolimus appears to be effective in lymphangioma but requires further study.
authors.affiliation: Department of Pediatric Oncology, Hacettepe University, Cancer Institute, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Akyüz
authors.forename: Erman
authors.initials: E
authors.lastname: Ataş
authors.forename: Ali
authors.initials: A
authors.lastname: Varan
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008202:Lymphangioma / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D008297:Male; D011183:Postoperative Complications; D011433:Propranolol / Q000009:adverse effects*; D020123:Sirolimus / Q000627:therapeutic use*; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000903:Antibiotics, Antineoplastic; D011433:Propranolol; D020123:Sirolimus
keywords: lymphangioma; outcome; sirolimus; treatment