title: Biomarkers in adult congenital heart disease heart failure.
abstract: Most adults with congenital heart disease show high levels of natriuretic peptide (NP) when compared with normal controls. Levels of norepinephrine and NP were strongly related to outcome in studies that included many symptomatic patients, especially those with unrepaired congenital heart disease, Eisenmenger syndrome, and pulmonary hypertension. Limited data are available regarding serial assessment of biomarkers; such information could provide additional important information to help identify patients at risk, as demonstrated during patient follow-up and pregnancy.
authors.affiliation: Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan; Department of Adult Congenital Heart Disease, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan. Electronic address: hohuchi@hsp.ncvc.go.jp.
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohuchi
authors.forename: Gerhard-Paul
authors.initials: GP
authors.lastname: Diller
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000150:complications / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D013223:Statistics as Topic; D018754:Ventricular Dysfunction / Q000097:blood
chemical_list: D015415:Biomarkers; D045265:Natriuretic Peptides; D009638:Norepinephrine
keywords: Adult congenital heart disease; Biomarker; Heart failure; Mortality; Natriuretic peptide; Ventricular dysfunction