title: Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas.
abstract: We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.
authors.affiliation: Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, Montreal, Canada. tomislav.friscic@mcgill.ca.
authors.forename: Davin
authors.initials: D
authors.lastname: Tan
authors.forename: Vjekoslav
authors.initials: V
authors.lastname: Štrukil
authors.forename: Cristina
authors.initials: C
authors.lastname: Mottillo
authors.forename: Tomislav
authors.initials: T
authors.lastname: Friščić
mesh_terms: D002384:Catalysis; D002747:Chlorpropamide / Q000138:chemical synthesis*; D003300:Copper / Q000737:chemistry*; D005905:Glyburide / Q000138:chemical synthesis*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D017879:Isothiocyanates / Q000737:chemistry*; D015394:Molecular Structure; D013449:Sulfonamides / Q000737:chemistry*; D014044:Tolbutamide / Q000138:chemical synthesis*
chemical_list: D007004:Hypoglycemic Agents; D017879:Isothiocyanates; D013449:Sulfonamides; D003300:Copper; D014044:Tolbutamide; D005905:Glyburide; D002747:Chlorpropamide