title: Hyperhomocysteinemia in chronic alcoholism: A case with retinal manifestations.
abstract: METHODS
  An alcoholic patient with loss of vision in his right eye and a peripapillar haemorrhage, who then presented with a venous thrombosis. Blood analysis revealed hyperhomocysteinemia with coagulation parameters within the normal range. In the follow-up he developed a bilateral optic neuropathy.
  
  
  CONCLUSIONS
  An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor. Folic acid and vitamins B6 and B12 deficiency may lead to hyperhomocysteinemia, as they participate in its metabolism.
  
  
  CONCLUSIONS
  When presented with a retinal occlusive disease or ischemic optic neuropathy in young patients, coagulation disorders and elevated levels of homocysteine should be ruled out.
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España. Electronic address: laurapalmerof@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Palmero-Fernández
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Treguerres
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Santos-Bueso
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Sáenz-Francés
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-de-la-Casa
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Feijóo
authors.affiliation: Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Sánchez
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000209:etiology*; D008297:Male; D012164:Retinal Diseases / Q000209:etiology*
keywords: Alcoholism; Alcoholismo; Hiperhomocisteinemia; Hyperhomocysteinemia; Neuropatía óptica; Oclusión venosa retiniana; Optic neuropathy; Retinal vein occlusion