title: Continuous spike and wave in slow-wave sleep in a patient with Rett syndrome and in a patient with Lhermitte-Duclos syndrome and neurofibromatosis 1.
abstract: Continuous spike and wave in slow-wave sleep (CSWS) is an electroencephalographic (EEG) pattern characterized by generalized spike-wave discharges occurring for at least 85% of non-rapid eye movement (non-REM) sleep, with marked attenuation during rapid eye movement (REM) sleep. It has been described in a large number of structural and nonstructural neurologic conditions and is associated with epilepsy, behavioral disturbances, and severe neuropsychiatric impairment. We describe continuous spike and wave in slow-wave sleep in 2 patients (one with Rett syndrome and the other with Lhermitte-Duclos syndrome). To our knowledge, continuous spike and wave in slow-wave sleep has not been previously described in these conditions.
authors.affiliation: NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA sbhat2012@yahoo.com.
authors.forename: Sushanth
authors.initials: S
authors.lastname: Bhat
authors.affiliation: NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA Department of Neurology and Neurosciences, New Jersey Medical School UMDNJ Newark, Newark, NJ, USA.
authors.forename: Xue
authors.initials: X
authors.lastname: Ming
authors.affiliation: NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA.
authors.forename: Rony
authors.initials: R
authors.lastname: Dekermenjian
authors.affiliation: NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA.
authors.forename: Sudhansu
authors.initials: S
authors.lastname: Chokroverty
mesh_terms: D058256:Brain Waves / Q000235:genetics / Q000502:physiology*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications*; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009456:Neurofibromatosis 1 / Q000150:complications*; D015518:Rett Syndrome / Q000150:complications*; D012890:Sleep / Q000502:physiology*
chemical_list: C497392:MECP2 protein, human; D051783:Methyl-CpG-Binding Protein 2
keywords: CSWS; Cowden disease; Lhermitte-Duclos syndrome; Rett syndrome; continuous spike and wave in slow-wave sleep