title: Flavonoids promoting HaCaT migration: I. Hologram quantitative structure-activity relationships.
abstract: Cell migration plays an important role in multicellular development and preservation. Because wound healing requires cell migration, compounds promoting cell migration can be used for wound repair therapy. Several plant-derived polyphenols are known to promote cell migration, which improves wound healing. Previous studies of flavonoids on cell lines have focused on their inhibitory effects and not on wound healing. In addition, studies of flavonoids on wound healing have been performed using mixtures. In this study, individual flavonoids were used for cellular migration measurements. Relationships between the cell migration effects of flavonoids and their structural properties have never been reported. Here, we investigated the migration of keratinocytes caused by 100 flavonoids and examined their relationships using hologram quantitative structure-activity relationships. The structural conditions responsible for efficient cell migration on keratinocyte cell lines determined from the current study will facilitate the design of flavonoids with improved activity.
authors.affiliation: Department of Biochemistry, School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Moonjae
authors.initials: M
authors.lastname: Cho
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Hyuk
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Mijoo
authors.initials: M
authors.lastname: Park
authors.affiliation: National Institute of Animal Science, Rural Development Administration, Cheonan 330-801, Republic of Korea.
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: yoongho@konkuk.ac.kr.
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D005419:Flavonoids
keywords: Cell migration; Flavonoids; HQSAR; Wound healing