title: Physiological responses and evaluation of effects of BMI, smoking and drinking in high altitude acclimatization: a cohort study in Chinese Han young males.
abstract: High altitude acclimatization is a series of physiological responses taking places when subjects go to altitude. Many factors could influence these processes, such as altitude, ascending speed and individual characteristics. In this study, based on a repeated measurement design of three sequential measurements at baseline, acute phase and chronic phase, we evaluated the effect of BMI, smoking and drinking on a number of physiological responses in high altitude acclimatization by using mixed model and partial least square path model on a sample of 755 Han Chinese young males. We found that subjects with higher BMI responses were reluctant to hypoxia. The effect of smoking was not significant at acute phase. But at chronic phase, red blood cell volume increased less while respiratory function increased more for smoking subjects compared with nonsmokers. For drinking subjects, red blood cell volume increased less than nondrinkers at both acute and chronic phases, while blood pressures increased more than nondrinkers at acute phase and respiratory function, red blood cell volume and oxygen saturation increased more than nondrinkers at chronic phase. The heavy and long-term effect of smoking, drinking and other factors in high altitude acclimatization needed to be further studied.
authors.affiliation: MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Peng
authors.forename: Zhuoma
authors.initials: Z
authors.lastname: Basang
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Cui
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Ji
authors.initials: J
authors.lastname: Qian
authors.forename: Quzhen
authors.initials: Q
authors.lastname: Gesang
authors.forename: La
authors.initials: L
authors.lastname: Yang
authors.forename: Zong
authors.initials: Z
authors.lastname: La
authors.forename: Yang
authors.initials: Y
authors.lastname: De
authors.forename: Puchi
authors.initials: P
authors.lastname: Dawa
authors.forename: Ni
authors.initials: N
authors.lastname: Qu
authors.forename: Qu
authors.initials: Q
authors.lastname: Suo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dan
authors.forename: Duoji
authors.initials: D
authors.lastname: Xiao
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Jin
mesh_terms: D000064:Acclimatization / Q000187:drug effects / Q000502:physiology*; D000293:Adolescent; D000531:Altitude; D044466:Asian People; D015992:Body Mass Index; D004326:Drinking / Q000502:physiology*; D006801:Humans; D008297:Male; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult