title: High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies.
abstract: Systemic sclerosis (SSc)-related autoantibodies are useful tools in identifying clinically homogenous subsets of patients and predicting their prognosis. In this report, we described five SSc patients with anti-centriole antibodies. All five patients were females and had digital ulcers/gangrene. Four of five (80%) patients had pulmonary arterial hypertension (PAH). None of the five patients had active pulmonary fibrosis or developed renal crisis. Anti-centriole antibodies may be a marker for PAH and digital ulcers/gangrene.
authors.affiliation: a Department of Dermatology , Faculty of Medicine, Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences , Kanazawa , Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Minoru
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ueda-Hayakawa
authors.forename: Sinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takehara
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
mesh_terms: D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002502:Centrioles / Q000276:immunology*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers
keywords: Anti-centriole antibody; Peripheral vasculopathy; Pulmonary arterial hypertension; Systemic sclerosis