title: Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever.
abstract: The aim of the present study was to evaluate renal involvement in children with Crimean-Congo hemorrhagic fever (CCHF). Forty-four children infected with CCHF virus and 30 controls were enrolled in the study. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine protein levels were measured in the patient and control groups. Clinical and laboratory findings of the patient and control groups were compared. uNGAL levels were higher in the patient group than that in the control group (P < 0.001). Of the 44 patients, 26 (59.1%) were proteinuric. uNGAL levels in proteinuric patients were higher than those in non-proteinuric patients (P = 0.035). There was a positive correlation between uNGAL and urine protein levels in the patient group. (R = 0.614, P < 0.001). Due to renal involvement, increased proteinuria and increased uNGAL levels were observed in children with CCHF. In these children, measuring urine total protein and uNGAL levels can be useful to monitor renal involvement due to CCHF.
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Cumhuriyet University.
authors.forename: Köksal
authors.initials: K
authors.lastname: Deveci
authors.forename: Elif Bilge
authors.initials: EB
authors.lastname: Uysal
authors.forename: Ali
authors.initials: A
authors.lastname: Kaya
authors.forename: Enver
authors.initials: E
authors.lastname: Sancakdar
authors.forename: Filiz
authors.initials: F
authors.lastname: Alkan
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000503:physiopathology* / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology* / Q000503:physiopathology / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008297:Male; D011507:Proteinuria / Q000382:microbiology / Q000503:physiopathology / Q000652:urine; D011518:Proto-Oncogene Proteins / Q000652:urine; D014421:Turkey
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins