title: Two new compounds from an Indonesian sponge Dysidea sp.
abstract: On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3-6. The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC50 values of 8.3 and 4.7 μg ml(- 1), respectively.
authors.affiliation: a Department of Marine Sciences , Diponegoro University , Tembalang-Semarang Central Java Indonesia 50275 .
authors.forename: Agus
authors.initials: A
authors.lastname: Trianto
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voodg
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001389:Azirines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047088:Dysidea / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D001389:Azirines; D005663:Furans; C587130:biaketide; C587131:debromoantazirine