title: The effects of dopaminergic medication on dynamic decision making in Parkinson's disease.
abstract: In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.
authors.affiliation: Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom; Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom; Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom. Electronic address: M.Osman@qmul.ac.uk.
authors.forename: Magda
authors.initials: M
authors.lastname: Osman
authors.affiliation: Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom; Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom.
authors.forename: Agata
authors.initials: A
authors.lastname: Ryterska
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom.
authors.forename: Kash
authors.initials: K
authors.lastname: Karimi
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, 3 East Qingchun Road, 310016 Hangzhou, Zhejiang, China.
authors.forename: LingLing
authors.initials: L
authors.lastname: Tu
authors.affiliation: Psychology Department at the St. George Campus, University of Toronto, 100 St. George Street, 4th Floor, Sidney Smith Hall, Toronto, Ontario, Canada M5S 3G3.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Obeso
authors.affiliation: Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom.
authors.forename: Maarten
authors.initials: M
authors.lastname: Speekenbrink
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom.
authors.forename: Marjan
authors.initials: M
authors.lastname: Jahanshahi
mesh_terms: D000368:Aged; D003463:Cues; D003657:Decision Making / Q000187:drug effects*; D015259:Dopamine Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006040:Goals; D006801:Humans; D007858:Learning / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy*; D013647:Task Performance and Analysis
chemical_list: D015259:Dopamine Agents; D007980:Levodopa
keywords: Dopamine overdosing hypothesis; Intervention; Learning; Prediction; dynamic decision making