title: Into the wild world of eosinophilic granuloma.
abstract: Langerhans cell histiocytosis (LCH) is a group of relatively rare disease processes of reticuloendothelial system with an abnormal proliferation of Langerhans cells or their precursors. A wide spectrum of treatment modalities is available for LCH which includes surgery, curettage, steroids, radiation, various chemotherapy regimens, either in combination or alone have so far been adopted. There are several case reports of eosinophilic granuloma but for recurrent cases very few have discussed on treatment of LCH in adults. We report a case of a 21-year-old man presented with eosinophilic granuloma with recurrence of the lesions after 6 years of the initial treatment. Patient was treated with combination chemotherapy with three weekly CHOP regimen and the patient is disease free after 6 months of follow-up. Contrary to other reports, this case demonstrates that a good response with standard therapy is possible.
authors.affiliation: Department of Radiation Oncology, Post Graduate Institute of Medical Sciences Rohtak, Haryana, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Dhull
authors.forename: Sumeet
authors.initials: S
authors.lastname: Aggarwal
authors.forename: Vivek
authors.initials: V
authors.lastname: Kaushal
authors.forename: Sunita
authors.initials: S
authors.lastname: Singh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D004803:Eosinophilic Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005881:Gingiva / Q000473:pathology; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use; D011862:Radiography, Panoramic; D012008:Recurrence; D014750:Vincristine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone