title: Malignant epithelioid hemangioendothelioma of the lip: a case report and comprehensive literature review.
abstract: Malignant epithelioid hemangioendothelioma (MEH), also known as high-risk epithelioid hemangioendothelioma, is a low- to intermediate-grade vascular malignancy originally described as a vascular neoplasm of endothelial origin. This very rare vascular neoplasm has been described mainly in soft tissue, but also in various organs and locations, including the liver, lung, brain, colon, lymph nodes, peritoneum, spleen, bone, skin, heart, soft tissues, and vascular system. Several cases have been described in the head and neck, including the submandibular gland, parotid gland, nasal cavity, parapharyngeal space, maxilla, maxillary sinus, occipital bone, oral cavity, thyroid gland, neck, scalp, larynx, and mandible. This case report is the first description of MEH presenting as an exophytic lower-lip lesion.
authors.affiliation: Chief Resident, Division of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, Torrance, CA.
authors.forename: Allen A
authors.initials: AA
authors.lastname: Robinson
authors.affiliation: Consulting Staff; Anatomic and Clinical Pathologist, Martin Luther King, Jr-Multiservice Ambulatory Care Center, Health Sciences; Assistant Clinical Professor III, David Geffen School of Medicine, UCLA, Los Angeles, CA; Clinical Assistant Professor, Charles Drew University of Medicine and Science, Los Angeles, CA; Pathology Consulting Staff Member, Rancho Los Amigos National Rehabilitation Center, Downey, CA.
authors.forename: Lucilene F
authors.initials: LF
authors.lastname: Tolentino
authors.affiliation: Attending Staff, Division of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, Torrance, CA; Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA.
authors.forename: Jettie
authors.initials: J
authors.lastname: Uyanne
authors.affiliation: Professor Emeritus, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA.; Attending Staff (Consulting), Department of Oral Pathology, Harbor-UCLA Medical Center.
authors.forename: Raymond
authors.initials: R
authors.lastname: Melrose
authors.affiliation: Attending Staff, Division of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, Torrance, CA; Assistant Professor, Charles Drew University of Medicine and Science, Los Angeles, CA; Lecturer, Section of Oral and Maxillofacial Surgery, UCLA, Los Angeles, CA. Electronic address: cccddsphd@yahoo.com.
authors.forename: Colonya C
authors.initials: CC
authors.lastname: Calhoun
mesh_terms: D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis*; D006801:Humans; D008046:Lip / Q000601:surgery; D008048:Lip Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D060787:Neoplasm Grading; D019226:Oral Ulcer / Q000175:diagnosis