title: Therapeutic target database update 2014: a resource for targeted therapeutics.
abstract: Here we describe an update of the Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/ttd.asp) for better serving the bench-to-clinic communities and for enabling more convenient data access, processing and exchange. Extensive efforts from the research, industry, clinical, regulatory and management communities have been collectively directed at the discovery, investigation, application, monitoring and management of targeted therapeutics. Increasing efforts have been directed at the development of stratified and personalized medicines. These efforts may be facilitated by the knowledge of the efficacy targets and biomarkers of targeted therapeutics. Therefore, we added search tools for using the International Classification of Disease ICD-10-CM and ICD-9-CM codes to retrieve the target, biomarker and drug information (currently enabling the search of almost 900 targets, 1800 biomarkers and 6000 drugs related to 900 disease conditions). We added information of almost 1800 biomarkers for 300 disease conditions and 200 drug scaffolds for 700 drugs. We significantly expanded Therapeutic Target Database data contents to cover >2300 targets (388 successful and 461 clinical trial targets), 20 600 drugs (2003 approved and 3147 clinical trial drugs), 20,000 multitarget agents against almost 400 target-pairs and the activity data of 1400 agents against 300 cell lines.
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore, Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456, Singapore, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China, State Key Laboratory of Medicinal Chemistry & Biology, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, People's Republic of China, Computation and Systems Biology, Singapore-MIT Alliance, National University of Singapore, Singapore and Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, People's Republic of China.
authors.forename: Chu
authors.initials: C
authors.lastname: Qin
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Shang Ying
authors.initials: SY
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Ying Hong
authors.initials: YH
authors.lastname: Li
authors.forename: Sheng Yong
authors.initials: SY
authors.lastname: Yang
authors.forename: Yu Quan
authors.initials: YQ
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.forename: Yu Zong
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D054316:Biomarkers, Pharmacological; D062126:Databases, Chemical; D004194:Disease / Q000145:classification; D006801:Humans; D020407:Internet; D058990:Molecular Targeted Therapy; D057285:Precision Medicine
chemical_list: D054316:Biomarkers, Pharmacological