title: [Clinical observation of preoperative administration of enteral nutrition support in gastric cancer patients at risk of malnutrition].
abstract: OBJECTIVE
  To evaluate safety and efficacy of preoperative administration of enteral nutrition support in gastric cancer patients at risk of malnutrition.
  
  
  METHODS
  A single center randomized controlled clinical trial was performed in 60 gastric cancer patients in West China Hospital from May to October 2012. Thirty patients were given enteral nutrition support(Ensure(R)) manufactured by Abbott Laboratories for ten consecutive days before surgical operation in the treatment group, and 30 patients were given an isocaloric and isonitrogenous homogenized diet in the control group for 10 days as well. The laboratory parameters of nutritional status and hepatorenal function were observed and compared between the two groups on admission, preoperative day 1 and postoperative day 3, respectively. Clinical observations, such as nausea and vomiting, were carried out until patients were discharged.
  
  
  RESULTS
  Before the intervention, there were no significant differences in the baseline characteristics between the two groups. The levels of serum albumin [(33.9±5.6) g/L vs. (31.0±5.3) g/L, P<0.05], and hemoglobin[(103.4±7.7) g/L vs.(96.6±10.5) g/L, P<0.01] were significantly improved in the treatment group on postoperative day 3. However, the levels of body mass index, lymphocyte count, liver and renal function, serum glucose, sodium, and potassium were not significantly different between the two groups(all P>0.05). Moreover, two patients with nausea and one with vomiting in each group were found. In clinical observation period, no severe treatment-related adverse event were observed.
  
  
  CONCLUSIONS
  The enteral supplement with Ensure(R) in gastric cancer patients at risk of malnutrition during preoperative period is effective and safe, which is superior to homogenized diet and an appropriate choice for gastric cancer patients with nutritional risk.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. wxt1@medmail.com.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Xian-peng
authors.initials: XP
authors.lastname: Qin
authors.forename: Ning-ning
authors.initials: NN
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: He
authors.forename: Jin-yan
authors.initials: JY
authors.lastname: Feng
authors.forename: Chuan-jing
authors.initials: CJ
authors.lastname: Yan
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Wu
mesh_terms: D006801:Humans; D004750:Enteral Nutrition; D005743:Gastrectomy / Q000009:adverse effects; D044342:Malnutrition / Q000209:etiology / Q000517:prevention & control; D009752:Nutritional Status; D011184:Postoperative Period; D011300:Preoperative Care / Q000379:methods; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000601:surgery