title: Erythrocyte osmotic fragility increases with serum advanced glycated end products in cigarette smokers.
abstract: BACKGROUND
  This study examines the relationship between circulating advanced glycated end products (AGEs) level and erythrocyte osmotic fragility in smokers.
  
  
  METHODS
  Forty-eight smokers (aged 45 ± 5 years) and fifty healthy nonsmokers (aged 42 ± 6 years) were selected in this study. All subjects were analysed according to serum AGEs, osmotic fragility (H50, the NaCL concentration producing 50% hemolysis), malondialdehyde (MDA) and advanced oxidation protein products (AOPP).
  
  
  RESULTS
  The data show that the serum AGEs, H50, MDA and AOPP levels were significantly higher for smokers than that of nonsmokers (p < 0.01). The serum AGEs correlated with H50 in smokers (r = 0.7703, p < 0.01). MDA levels correlated with H50 in smokers (r = 0.7584, p < 0.01).
  
  
  CONCLUSIONS
  This study demonstrated that serum AGEs and MDA levels positively correlated with osmotic fragility in smokers.
authors.affiliation: Laboratory for Development, College of Life Sciences, Northwest University, Xi'an Shaanxi, China National Engineering Research Center for Miniaturized Detection System, Northwest University, Xi'an Shaanxi, China.
authors.forename: Rulin
authors.initials: R
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing, China.
authors.forename: Xuyang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D009996:Osmotic Fragility; D018384:Oxidative Stress; D012907:Smoking / Q000097:blood* / Q000378:metabolism / Q000473:pathology
chemical_list: D017127:Glycation End Products, Advanced; D008315:Malondialdehyde
keywords: Advanced glycated end products; cigarette smoker; osmotic fragility