title: The search for ESR1 mutations in breast cancer.
abstract: Two new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor-resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful in the management of endocrine-resistant breast cancer.
authors.affiliation: Department of Pharmacology and Chemical Biology and Department of Medicine, University of Pittsburgh, Women's Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, and Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
authors.forename: Steffi
authors.initials: S
authors.lastname: Oesterreich
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Davidson
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D020125:Mutation, Missense; D054730:Protein Interaction Domains and Motifs / Q000235:genetics*
chemical_list: D018931:Antineoplastic Agents, Hormonal; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha