title: Fertility and pregnancy outcome in a woman with classic congenital adrenal hyperplasia.
abstract: A 24-year-old woman with 21-hydroxylase deficient classic congenital adrenal hyperplasia, simple virilising form presented with secondary infertility. One year ago she had a spontaneous miscarriage in the second trimester of pregnancy. This time she conceived with prednisolone 5 mg and clomiphene citrate 100 mg. She was then continued with prednisolone during pregnancy. She had a spontaneous preterm delivery at 33 weeks. There was a marginal increase in the dose of prednisolone during pregnancy. There was no worsening of insulin resistance during pregnancy despite prednisolone administration. A normal healthy female infant was born and is being followed up on for ill-effects, if any, of maternal glucocorticoid administration during pregnancy. The baby girl has normal female external genitalia.
authors.affiliation: Department of Gynaecology, Chotu Ram Hospital, Rohtak, Haryana, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Jain
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005298:Fertility; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D050498:Live Birth; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone