title: Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry.
abstract: BACKGROUND
  There is no large report of the impact of fractional flow reserve (FFR) on the reclassification of the coronary revascularization strategy on individual patients referred for diagnostic angiography.
  
  
  RESULTS
  The Registre Français de la FFR (R3F) investigated 1075 consecutive patients undergoing diagnostic angiography including an FFR investigation at 20 French centers. Investigators were asked to define prospectively their revascularization strategy a priori based on angiography before performing the FFR. The final revascularization strategy, reclassification of the strategy by FFR, and 1-year clinical follow-up were prospectively recorded. The strategy a priori based on angiography was medical therapy in 55% and revascularization in 45% (percutaneous coronary intervention, 38%; coronary artery bypass surgery, 7%). Patients were treated according to FFR in 1028/1075 (95.7%). The applied strategy after FFR was medical therapy in 58% and revascularization in 42% (percutaneous coronary intervention, 32%; coronary artery bypass surgery, 10%). The final strategy applied differed from the strategy a priori in 43% of cases: in 33% of a priori medical patients, in 56% of patients undergoing a priori percutaneous coronary intervention, and in 51% of patients undergoing a priori coronary artery bypass surgery. In reclassified patients treated based on FFR and in disagreement with the angiography-based a priori decision (n=464), the 1-year outcome (major cardiac event, 11.2%) was as good as in patients in whom final applied strategy concurred with the angiography-based a priori decision (n=611; major cardiac event, 11.9%; log-rank, P=0.78). At 1 year, >93% patients were asymptomatic without difference between reclassified and nonreclassified patients (Generalized Linear Mixed Model, P=0.75). Reclassification safety was preserved in high-risk patients.
  
  
  CONCLUSIONS
  This study shows that performing FFR during diagnostic angiography is associated with reclassification of the revascularization decision in about half of the patients. It further demonstrates that it is safe to pursue a revascularization strategy divergent from that suggested by angiography but guided by FFR.
authors.affiliation: Departments of Cardiology, University Hospital (E.V.B.); EA2693, Lille-II-University (E.V.B.); Hôpital Louis Pradel, Lyon (G.R.); INSERM 1060 CARMEN, Claude Bernard University Lyon1 (G.R,); Clinique Sainte Clotilde, Saint Denis de la Réunion (C.P., K.B.); CHU La Timone, Marseille (T.C.); CHU Mondor, Créteil (E.T., S.C.); CH d'Annecy, Annecy (L.B.); C.H.I.T.S. Hôpital Sainte Musse, Toulon (D.B.); Centre Hospitalier Haguenau, Haguenau (M.H.); Hôpital de la Croix-Rousse, Lyon (C.B., R.D.); Institut Pasteur de Lille-INSERM (J.D.), Université Pierre et Marie Curie - Paris 6 (Y.E.H.), Hôpital lariboisière (G.S.), Paris; Centre Hospitalier Valence, Valence (C.B.); Hôpital Albert Schweizer, Colmar (N.L.); Centre Hospitalier La Durance, Avignon (P.B.); Centre Hospitalier Amiens Sud, Amiens (L.L.); and Hopital Privé d'Antony, Antony, France (P.D.).
authors.forename: Eric
authors.initials: E
authors.lastname: Van Belle
authors.forename: Gilles
authors.initials: G
authors.lastname: Rioufol
authors.forename: Christophe
authors.initials: C
authors.lastname: Pouillot
authors.forename: Thomas
authors.initials: T
authors.lastname: Cuisset
authors.forename: Karim
authors.initials: K
authors.lastname: Bougrini
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Teiger
authors.forename: Stéphane
authors.initials: S
authors.lastname: Champagne
authors.forename: Loic
authors.initials: L
authors.lastname: Belle
authors.forename: Didier
authors.initials: D
authors.lastname: Barreau
authors.forename: Michel
authors.initials: M
authors.lastname: Hanssen
authors.forename: Cyril
authors.initials: C
authors.lastname: Besnard
authors.forename: Raphael
authors.initials: R
authors.lastname: Dauphin
authors.forename: Jean
authors.initials: J
authors.lastname: Dallongeville
authors.forename: Yassine
authors.initials: Y
authors.lastname: El Hahi
authors.forename: Georgios
authors.initials: G
authors.lastname: Sideris
authors.forename: Christophe
authors.initials: C
authors.lastname: Bretelle
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lhoest
authors.forename: Pierre
authors.initials: P
authors.lastname: Barnay
authors.forename: Laurent
authors.initials: L
authors.lastname: Leborgne
authors.forename: Patrick
authors.initials: P
authors.lastname: Dupouy
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D003657:Decision Making; D023381:Endpoint Determination; D005260:Female; D005500:Follow-Up Studies; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D062645:Percutaneous Coronary Intervention / Q000145:classification* / Q000379:methods; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: coronary angiography; coronary artery disease; fractional flow reserve; mortality; outcome assessment (health care)