title: Phosphinic Acid analogues of methylaspartic and methylglutamic acids as antibacterials.
abstract: DL-l-Amino-l-methyl-3-carboxypropanephosphinic acid, a bioisostere of α-methylglutamic acid, was synthesized. This compound, the corresponding α-methylaspartic acid analogue and their precursors were tested for antibacterial activity. The methylaspartic acid analogue gave a MIC of 400 and 800 µg/ml against B. subtilis and P. aeroginosa, respectively.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Houston - University Park, Houston, TX, 77004.
authors.forename: L A
authors.initials: LA
authors.lastname: Cates
authors.forename: V S
authors.initials: VS
authors.lastname: Li