title: The oxidative stress response of the opportunistic fungal pathogen Candida glabrata.
abstract: Organisms have evolved different strategies to respond to oxidative stress generated as a by-product of aerobic respiration and thus maintain the redox homeostasis within the cell. In particular, fungal pathogens are exposed to reactive oxygen species (ROS) when they interact with the phagocytic cells of the host which are the first line of defense against fungal infections. These pathogens have co-opted the enzymatic (catalases, superoxide dismutases (SODs), and peroxidases) and non-enzymatic (glutathione) mechanisms used to maintain the redox homeostasis within the cell, to resist oxidative stress and ensure survival within the host. Several virulence factors have been related to the response to oxidative stress in pathogenic fungi. The opportunistic fungal pathogen Candida glabrata (C. glabrata) is the second most common cause of candidiasis after Candida albicans (C. albicans). C. glabrata has a well defined oxidative stress response (OSR), which include both enzymatic and non-enzymatic mechanisms. C. glabrata OSR is controlled by the well-conserved transcription factors Yap1, Skn7, Msn2 and Msn4. In this review, we describe the OSR of C. glabrata, what is known about its core elements, its regulation and how C. glabrata interacts with the host. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Marcela
authors.initials: M
authors.lastname: Briones-Martin-Del-Campo
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Orta-Zavalza
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Juarez-Cepeda
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Gutierrez-Escobedo
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Israel
authors.initials: I
authors.lastname: Cañas-Villamar
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México.
authors.forename: Irene
authors.initials: I
authors.lastname: Castaño
authors.affiliation: División de Biología Molecular, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí, México. Electronic address: cano@ipicyt.edu.mx.
authors.forename: Alejandro
authors.initials: A
authors.lastname: De Las Peñas
mesh_terms: D000222:Adaptation, Physiological; D041221:Candida glabrata / Q000378:metabolism* / Q000472:pathogenicity; D002177:Candidiasis / Q000382:microbiology; D002374:Catalase / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D005978:Glutathione / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D016867:Immunocompromised Host; D008668:Metallothionein / Q000502:physiology; D009894:Opportunistic Infections / Q000382:microbiology; D018384:Oxidative Stress; D010587:Phagocytosis; D010860:Pigments, Biological / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000502:physiology; D013879:Thioredoxins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014774:Virulence
chemical_list: D005656:Fungal Proteins; D010860:Pigments, Biological; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D013879:Thioredoxins; D008668:Metallothionein; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Candida glabrata; Cta1; Especies reactivas del oxígeno; Glutathione; Glutatión; Reactive oxygen species; Skn7; Yap1