title: FACT and the H2B N tail.
abstract: The FACT histone chaperone/nucleosome reorganization factor plays key roles in nucleosome dynamics during transcription. A new study has linked a specific domain in the H2B N terminus to the activity of FACT in regulating nucleosome disassembly at promoters during transcription activation and nucleosome reassembly at coding regions during transcription elongation.
authors.affiliation: Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Osley
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D009707:Nucleosomes / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D035602:Transcriptional Elongation Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C541535:FACT protein, S cerevisiae; D006609:High Mobility Group Proteins; D006657:Histones; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; D035602:Transcriptional Elongation Factors