title: NOV promoted the growth and migration of pancreatic cancer cells.
abstract: NOV, a member of the CCN (Cyr61, CTGF and NOV) family, is involved in diverse biological processes, such as cell adhesion, proliferation and angiogenesis. However, its function in pancreatic cancer remains poorly understood. Here, we found that the expression of NOV was up-regulated in pancreatic cancer tissues. Moreover, over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo. Mechanistically, NOV induced epithelial-mesenchymal transition (EMT) and regulated the expression of multiple EMT marker. Taken together, our study suggested the important role of NOV in pancreatic cancer and NOV might be an important therapeutic target.
authors.affiliation: General Surgery Department, Affiliated hospital, Jiangsu University, Zhenjiang, Jiangsu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.forename: Rong
authors.initials: R
authors.lastname: Xie
authors.forename: Shenchun
authors.initials: S
authors.lastname: Dang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shengfa
authors.initials: S
authors.lastname: Mao
authors.forename: Jixiang
authors.initials: J
authors.lastname: Chen
authors.forename: Jianguo
authors.initials: J
authors.lastname: Qu
authors.forename: Jianxin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D055514:Nephroblastoma Overexpressed Protein / Q000235:genetics / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: C526319:CCN3 protein, human; D055514:Nephroblastoma Overexpressed Protein