title: The effect of feeding excess arginine on lipogenic gene expression and growth performance in broilers.
abstract: 1. Reducing excess fat accretion is important for both human health and animal production. The present study was conducted to investigate the effects of arginine (Arg) on the regulation of lipogenic gene expression and on growth performance. 2. One-d-old female broiler chicks (Ross, n = 192) were used in a completely randomised design with 4 dietary treatments in which diets included 100% (CTL), 153% (LArg), 168% (MArg) and 183% (HArg) of the recommended concentration of digestible Arg. 3. Results showed that high concentrations of Arg improved body weight gain, feed efficiency, meat production, fat and crude protein content of breast muscle and plasma thyroid hormones. Conversely, abdominal fat, cholesterol, triglyceride and urea were lower with higher concentrations of Arg. Dietary arginine increased lipogenic gene expression in muscles, while decreasing those in adipose tissue and liver. 4. It was concluded that increasing Arg in the diet reduced abdominal fat content, enhanced intramuscular fat and increased muscle and protein gain. Furthermore, Arg supplementation at the MArg concentration improved growth performance, and at HArg had the greatest effect on fat reduction.
authors.affiliation: a Faculty of Agricultural Science , University of Tabriz , Tabriz , Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: A
authors.initials: A
authors.lastname: Zare Shahneh
authors.forename: M
authors.initials: M
authors.lastname: Shivazad
authors.forename: Z
authors.initials: Z
authors.lastname: Ansari Pirsaraei
authors.forename: M
authors.initials: M
authors.lastname: Tebianian
authors.forename: C A
authors.initials: CA
authors.lastname: Ruiz-Feria
authors.forename: M
authors.initials: M
authors.lastname: Adibmoradi
authors.forename: K
authors.initials: K
authors.lastname: Nourijelyani
authors.forename: F
authors.initials: F
authors.lastname: Mohamadnejad
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002645:Chickens / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D050155:Lipogenesis; D008099:Liver / Q000378:metabolism; D008460:Meat / Q000032:analysis; D018482:Muscle, Skeletal / Q000378:metabolism; D011897:Random Allocation
chemical_list: D001120:Arginine