title: Correlation between liver fat content with dyslipidemia and Insulin resistance.
abstract: Total 33 obese patients were studied to determine correlation in between liver fat content with dyslipidemia and insulin resistance. Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen. Hepatic attenuation indices were measured as follows: (1) Hepatic parenchymal attenuation (CTLP); (2) liver to spleen attenuation ratio (LSratio); and (3) difference between hepatic and splenic attenuation (LSdif). Bivariate correlation analysis showed moderate but statistically significant negative correlation between CTLP, LSratio, and LSdif with body mass index, triglyceride, fasting plasma sugar, fasting plasma insulin, homeostasis model assessment-insulin resistance (HOMA IR), 2 h oral glucose tolerance test (OGTT), and statistically significant positive correlation with high density lipoprotein. Nonalcoholic fatty liver disease (NAFLD) is closely associated with features of the metabolic syndrome. The amount of intrahepatic fat closely correlates with the number of metabolic syndrome features. The values of CTLP, LSratio, and LSdif demonstrate strong inverse correlations with degree of steatosis.
authors.affiliation: Department of Endocrinology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Saran
authors.forename: Rajeev
authors.initials: R
authors.lastname: Philip
authors.forename: Manish
authors.initials: M
authors.lastname: Gutch
authors.forename: Rajeev
authors.initials: R
authors.lastname: Tyagi
authors.forename: Puspalata
authors.initials: P
authors.lastname: Agroiya
authors.forename: Keshav Kumar
authors.initials: KK
authors.lastname: Gupta
keywords: Hepatic attenuation indices; homeostasis model of assessment insulin resistance; nonalcoholic fatty liver disease; waist-hip ratio