title: Role of Cdc42 dynamics in the control of fission yeast cell polarization.
abstract: Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and time-delayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.
authors.affiliation: *Biochemistry and Cellular and Molecular Biology, University of Tennessee, 1414 West Cumberland Avenue, Knoxville, TN 37996-0840, U.S.A.
authors.forename: Maitreyi
authors.initials: M
authors.lastname: Das
authors.forename: Fulvia
authors.initials: F
authors.lastname: Verde
mesh_terms: D016764:Cell Polarity; D012568:Schizosaccharomyces / Q000166:cytology* / Q000378:metabolism*; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism*
chemical_list: D020764:cdc42 GTP-Binding Protein