title: [Algorithm for diagnosis and treatment of hereditary angioedema as a tool for management].
abstract: BACKGROUND
  Hereditary angioedema is a disease with low prevalence and high heterogeneity with regards to the severity of the clinical picture, which makes the diagnosis difficult and requires the need for early start of specific treatment in order to prevent complications.
  
  
  OBJECTIVE
  To propose a decision algorithm for hereditary angioedema (HAE), based on the evidence available on the diagnosis, clinical assessment, and treatment. The aim is to present the available therapeutic options as well as a decision algorithm to select the most efficient therapy at each time.
  
  
  METHODS
  Literature search by means of PubMed and other relevant sources.
  
  
  RESULTS
  four decision algorithms have been developed for HAE; diagnosis of bradikinin-mediated angioedema, treatment of acute attacks and short and long-term prophylaxis for HAE due to C1 inhibitor deficiency.
  
  
  CONCLUSIONS
  The application of a decision algorithm based on the clinical variables helps to select the most efficient therapeutic option at each time and may be a useful tool for the therapeutic approach.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Baeza
authors.forename: Teresa
authors.initials: T
authors.lastname: Caballero Molina
authors.forename: Carlos
authors.initials: C
authors.lastname: Crespo Diz
authors.lastname: González-Quevedo
authors.forename: Mar
authors.initials: M
authors.lastname: Guilarte Clavero
authors.forename: Dolores
authors.initials: D
authors.lastname: Hernández Fernández de Rojas
authors.forename: Teófilo
authors.initials: T
authors.lastname: Lobera Labairu
authors.forename: Carmen
authors.initials: C
authors.lastname: Marcos Bravo
authors.forename: Andrés
authors.initials: A
authors.lastname: Navarro Ruiz
authors.affiliation: Servicio de Farmacia. Hospital General Universitario. Elche.
authors.forename: A
authors.initials: A
authors.lastname: Navarro Ruiz
authors.forename: José Luis
authors.initials: JL
authors.lastname: Poveda Andrés
authors.forename: J L
authors.initials: JL
authors.lastname: Poveda Andrés
authors.forename: María Antonia
authors.initials: MA
authors.lastname: Cebollero
authors.forename: A
authors.initials: A
authors.lastname: Cebollero de Torre
mesh_terms: D000465:Algorithms; D054179:Angioedemas, Hereditary / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D050718:Complement C1 Inhibitor Protein / Q000235:genetics; D006801:Humans; D010346:Patient Care Management / Q000379:methods*
chemical_list: D050718:Complement C1 Inhibitor Protein