title: Lynx: a database and knowledge extraction engine for integrative medicine.
abstract: We have developed Lynx (http://lynx.ci.uchicago.edu)--a web-based database and a knowledge extraction engine, supporting annotation and analysis of experimental data and generation of weighted hypotheses on molecular mechanisms contributing to human phenotypes and disorders of interest. Its underlying knowledge base (LynxKB) integrates various classes of information from >35 public databases and private collections, as well as manually curated data from our group and collaborators. Lynx provides advanced search capabilities and a variety of algorithms for enrichment analysis and network-based gene prioritization to assist the user in extracting meaningful knowledge from LynxKB and experimental data, whereas its service-oriented architecture provides public access to LynxKB and its analytical tools via user-friendly web services and interfaces.
authors.affiliation: Computation Institute, the University of Chicago, Chicago, IL 60637, USA, Department of Human Genetics, the University of Chicago, Chicago, IL 60637, USA, Department of Computer Science, Illinois Institute of Technology, Chicago, IL 60616, USA and Toyota Technological Institute at Chicago, Chicago, IL 60637, USA.
authors.forename: Dinanath
authors.initials: D
authors.lastname: Sulakhe
authors.forename: Sandhya
authors.initials: S
authors.lastname: Balasubramanian
authors.forename: Bingqing
authors.initials: B
authors.lastname: Xie
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Andrew
authors.initials: A
authors.lastname: Taylor
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Eduardo
authors.initials: E
authors.lastname: Berrocal
authors.forename: Utpal
authors.initials: U
authors.lastname: Dave
authors.forename: Jinbo
authors.initials: J
authors.lastname: Xu
authors.forename: Daniela
authors.initials: D
authors.lastname: Börnigen
authors.forename: T Conrad
authors.initials: TC
authors.lastname: Gilliam
authors.forename: Natalia
authors.initials: N
authors.lastname: Maltsev
mesh_terms: D001321:Autistic Disorder / Q000235:genetics; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D005796:Genes; D023281:Genomics; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D010641:Phenotype; D057386:Search Engine; D012640:Seizures / Q000235:genetics; D018511:Systems Integration