title: Bifacial PNA complexation inhibits enzymatic access to DNA and RNA.
abstract: FULL STOP: Herein we report the effective in vitro inhibition of transcription, reverse-transcription and exonuclease function by formation of synthetic bPNA-nucleic acid triplex structures. Selective bPNA targeting of both DNA and RNA substrates suggests possible application of bPNAs as synthetic regulators of nucleic acid function.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA).
authors.forename: Xin
authors.initials: X
authors.lastname: Xia
authors.forename: Xijun
authors.initials: X
authors.lastname: Piao
authors.forename: Kurt
authors.initials: K
authors.lastname: Fredrick
authors.forename: Dennis
authors.initials: D
authors.lastname: Bong
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000378:metabolism; D055029:Inverted Repeat Sequences; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D020135:Peptide Nucleic Acids; D014764:Viral Proteins; C051802:triplex DNA; D012313:RNA; D004247:DNA; C062210:bacteriophage T7 RNA polymerase; D012194:RNA-Directed DNA Polymerase; D012321:DNA-Directed RNA Polymerases
keywords: bPNA; bifacial; hairpin; nucleobases; structure-activity relationships