title: Heart transplantation in adults with congenital heart disease.
abstract: Heart transplantation has become an increasingly common and effective therapy for adults with end-stage congenital heart disease (CHD) because of advances in patient selection and surgical technique. Indications for transplantation in CHD are similar to other forms of heart failure. Pretransplant assessment of CHD patients emphasizes evaluation of cardiac anatomy, pulmonary vascular disease, allosensitization, hepatic dysfunction, and neuropsychiatric status. CHD patients experience longer waitlist times and higher waitlist mortality than other transplant candidates. Adult CHD patients undergoing transplantation carry an early hazard for mortality compared with non-CHD recipients, but by 10 years posttransplant, CHD patients have a slight actuarial survival advantage.
authors.affiliation: Division of Cardiovascular Medicine, Center for Advanced Heart Disease, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: gcstewart@partners.org.
authors.forename: Garrick C
authors.initials: GC
authors.lastname: Stewart
authors.forename: John E
authors.initials: JE
authors.lastname: Mayer
mesh_terms: D000328:Adult; D018450:Disease Progression; D006330:Heart Defects, Congenital / Q000145:classification / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D053208:Kaplan-Meier Estimate; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D011183:Postoperative Complications / Q000145:classification*; D011300:Preoperative Care / Q000379:methods*; D020379:Risk Adjustment; D012307:Risk Factors
keywords: Congenital; Heart defects; Heart failure; Heart transplantation; Patient selection