title: The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis.
abstract: OBJECTIVE
  It has been demonstrated that periodontitis induces systemic inflammation, which may impair endothelial function leading to increased cardiovascular risk. The aim of this study was to evaluate the effect of simvastatin on systemic inflammatory markers and endothelial dysfunction induced by periodontitis.
  
  
  METHODS
  Wistar rats were subjected to ligature-induced experimental periodontitis. Eight days after the procedure, the ligature and sham groups were randomly assigned to receive simvastatin or vehicle once a day until the 14th day, when the effects of acetylcholine and sodium nitroprusside on blood pressure were evaluated. Blood samples were collected and evaluated for plasma interleukin-6C, -reactive protein and lipids. The maxilla and mandible were removed for bone loss analysis.
  
  
  RESULTS
  Simvastatin treatment reduced systemic inflammation and endothelial dysfunction induced by periodontitis. Furthermore, simvastatin improved the blood lipid profile and reduced alveolar bone loss.
  
  
  CONCLUSIONS
  Simvastatin treatment, in addition to the improvement on serum lipid profile, may reduce other predictors of cardiovascular events associated with periodontitis.
authors.affiliation: Department of Pharmaceutical Sciences, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: W M
authors.initials: WM
authors.lastname: Machado
authors.forename: A P
authors.initials: AP
authors.lastname: Prestes
authors.forename: T P
authors.initials: TP
authors.lastname: Costa
authors.forename: R T
authors.initials: RT
authors.lastname: Mendes
authors.forename: L R
authors.initials: LR
authors.lastname: Olchanheski
authors.forename: R
authors.initials: R
authors.lastname: Sordi
authors.forename: M F
authors.initials: MF
authors.lastname: Otuki
authors.forename: G M
authors.initials: GM
authors.lastname: Fávero
authors.forename: J C R
authors.initials: JC
authors.lastname: Vellosa
authors.forename: F A
authors.initials: FA
authors.lastname: Santos
authors.forename: D
authors.initials: D
authors.lastname: Fernandes
mesh_terms: D000109:Acetylcholine / Q000627:therapeutic use; D016301:Alveolar Bone Loss / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000276:immunology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007249:Inflammation; D018836:Inflammation Mediators / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D008297:Male; D009599:Nitroprusside / Q000627:therapeutic use; D010518:Periodontitis / Q000276:immunology* / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; D014665:Vasodilator Agents; D009599:Nitroprusside; D002097:C-Reactive Protein; D019821:Simvastatin; D000109:Acetylcholine
keywords: endothelial dysfunction; periodontitis; simvastatin; systemic inflammation