title: Model cell membranes: discerning lipid and protein contributions in shaping the cell.
abstract: The high complexity of biological membranes has motivated the development and application of a wide range of model membrane systems to study biochemical and biophysical aspects of membranes in situ under well defined conditions. The aim is to provide fundamental understanding of processes controlled by membrane structure, permeability and curvature as well as membrane proteins by using a wide range of biochemical, biophysical and microscopic techniques. This review gives an overview of some currently used model biomembrane systems. We will also discuss some key membrane protein properties that are relevant for protein-membrane interactions in terms of protein structure and how it is affected by membrane composition, phase behavior and curvature.
authors.affiliation: Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
authors.forename: Thomas Günther
authors.initials: TG
authors.lastname: Pomorski
authors.affiliation: Department of Chemistry, Division of Physical Chemistry, Lund University, Gettingevägen 60, SE-22100 Lund, Sweden.
authors.forename: Tommy
authors.initials: T
authors.lastname: Nylander
authors.affiliation: Department of Chemistry/Nano-Science Center, University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address: cardenas@nano.ku.dk.
authors.forename: Marité
authors.initials: M
authors.lastname: Cárdenas
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological; D011506:Proteins / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D008055:Lipids; D011506:Proteins
keywords: Bilayers; Cell membranes; Lipids; Nanodiscs; Proteins; Vesicles