title: The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation.
abstract: During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.
authors.affiliation: Department of Pathology, Stanford University, Stanford, California. Electronic address: gjberry@stanford.edu.
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Berry
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Burke
authors.forename: Claus
authors.initials: C
authors.lastname: Andersen
authors.forename: Patrick
authors.initials: P
authors.lastname: Bruneval
authors.forename: Marny
authors.initials: M
authors.lastname: Fedrigo
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fishbein
authors.forename: Martin
authors.initials: M
authors.lastname: Goddard
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Hammond
authors.forename: Ornella
authors.initials: O
authors.lastname: Leone
authors.forename: Charles
authors.initials: C
authors.lastname: Marboe
authors.forename: Dylan
authors.initials: D
authors.lastname: Miller
authors.forename: Desley
authors.initials: D
authors.lastname: Neil
authors.forename: Doris
authors.initials: D
authors.lastname: Rassl
authors.forename: Monica P
authors.initials: MP
authors.lastname: Revelo
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rice
authors.forename: E
authors.initials: E
authors.lastname: Rene Rodriguez
authors.forename: Susan
authors.initials: S
authors.lastname: Stewart
authors.forename: Carmela D
authors.initials: CD
authors.lastname: Tan
authors.forename: Gayle L
authors.initials: GL
authors.lastname: Winters
authors.forename: Lori
authors.initials: L
authors.lastname: West
authors.forename: Mandeep R
authors.initials: MR
authors.lastname: Mehra
authors.forename: Annalisa
authors.initials: A
authors.lastname: Angelini
mesh_terms: D006801:Humans; D000906:Antibodies / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D015933:Complement C3d / Q000276:immunology; D006084:Graft Rejection / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D016027:Heart Transplantation; D016130:Immunophenotyping; D007391:International Cooperation; D009626:Terminology as Topic; D000097382:CD68 Molecule
chemical_list: D000906:Antibodies; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D015933:Complement C3d; D000097382:CD68 Molecule
keywords: activated mononuclear cells; antibody mediated rejection; complement; heart; immunofluorescence; immunohistochemistry; intravascular