title: Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea.
abstract: BACKGROUND
  This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.
  
  
  METHODS
  We prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.
  
  
  RESULTS
  A total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.
  
  
  CONCLUSIONS
  Significant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.
  ClinicalTrials.gov Registration number; NCT01616745.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea. yimjj@snu.ac.kr.
authors.forename: Ae-Ra
authors.initials: AR
authors.lastname: Lee
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Lee
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Choi
authors.forename: Moon-Woo
authors.initials: MW
authors.lastname: Seong
authors.forename: Sung A
authors.initials: SA
authors.lastname: Kim
authors.forename: Myoungsil
authors.initials: M
authors.lastname: Kim
authors.forename: Kyung Ok
authors.initials: KO
authors.lastname: Chae
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Lee
authors.forename: Jae-Joon
authors.initials: JJ
authors.lastname: Yim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000235:genetics / Q000302:isolation & purification*; D011446:Prospective Studies; D011859:Radiography; D056910:Republic of Korea; D055815:Young Adult