title: Do Postoperative Biomechanical Changes Induce Heterotopic Ossification After Cervical Arthroplasty?: A 5-Year Follow-up Study.
abstract: Prospective clinical study.
  
  
  
  To evaluate the factors that would predispose a patient to heterotopic ossification (HO) formation after cervical arthroplasty.
  
  
  
  HO after arthroplasty is one of the complications of cervical total disk replacement (TDR). However, the predisposing factors and pathophysiology of HO have not been precisely described.
  
  
  
  We prospectively enrolled and followed up 23 patients, who received single-level arthroplasty with ProDisc-C, for 5 years after the operation. The patients who developed grade 3 or 4 HO were classified into the "high-grade HO group," whereas the patients with grade 0, 1, or 2 HO were classified into the "low-grade HO group." We compared the postoperative changes in the range of motion (ROM) and height of the functional segmental unit (FSU) of the implantation segments between the 2 groups.
  
  
  
  The mean differences in height and ROM of the FSU were 2.59±1.42 mm and 6.7±3.2 degrees in the high-grade HO group, and 0.87±0.72 mm and 3.1±2.8 degrees in the low-grade HO group. The mean differences in height and ROM of the FSU were significantly higher in the high-grade HO group than in the low-grade HO group (P<0.05). After cervical arthroplasty, the height of the FSU and ROM of the implantation segments were significantly increased in the high-grade HO group compared with the low-grade HO group.
  
  
  
  Overcorrection of the height of the FSU and increase in the ROM of the implantation segment may influence the formation of HOs after cervical arthroplasty.
authors.affiliation: *Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Spine Hospital, Yonsei University College of Medicine, Seoul†Department of Neurosurgery, Spine Center, The Leon Wiltse Memorial Hospital, Gyeonggi-do, Korea.
authors.forename: Keun Su
authors.initials: KS
authors.lastname: Kim
authors.forename: Dong Hwa
authors.initials: DH
authors.lastname: Heo
mesh_terms: D000328:Adult; D001178:Arthroplasty / Q000009:adverse effects*; D001696:Biomechanical Phenomena; D002574:Cervical Vertebrae / Q000601:surgery*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology* / Q000503:physiopathology; D016059:Range of Motion, Articular; D012189:Retrospective Studies; D015898:Tomography Scanners, X-Ray Computed