title: Olfactory control of blood progenitor maintenance.
abstract: Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP:
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Shim
authors.forename: Tina
authors.initials: T
authors.lastname: Mukherjee
authors.forename: Bama Charan
authors.initials: BC
authors.lastname: Mondal
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Gloria Chin
authors.initials: GC
authors.lastname: Young
authors.forename: Dinali Priasha
authors.initials: DP
authors.lastname: Wijewarnasuriya
authors.forename: Utpal
authors.initials: U
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000166:cytology* / Q000502:physiology*; D006458:Hemolymph / Q000166:cytology*; D008221:Lymphoid Tissue / Q000166:cytology; D009474:Neurons / Q000378:metabolism; D055696:Olfactory Perception; D018034:Olfactory Receptor Neurons / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid