title: Metal-free nitro-carbocyclization of activated alkenes: a direct approach to synthesize oxindoles by cascade C-N and C-C bond formation.
abstract: A novel and direct metal-free nitro-carbocyclization of activated alkenes leading to valuable nitro-containing oxindoles via cascade C-N and C-C bond formation has been developed. The mechanistic study indicates that the initial NO and NO2 radical addition and the following C-H functionalization processes are involved in this transformation.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. jiaoning@bjmu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D000078183:Oxindoles
chemical_list: D000475:Alkenes; D007211:Indoles; D008670:Metals; D000078183:Oxindoles; C022960:2-oxindole; D002244:Carbon; D009584:Nitrogen