title: Progress in the development of paper-based diagnostics for low-resource point-of-care settings.
abstract: This Review focuses on recent work in the field of paper microfluidics that specifically addresses the goal of translating the multistep processes that are characteristic of gold-standard laboratory tests to low-resource point-of-care settings. A major challenge is to implement multistep processes with the robust fluid control required to achieve the necessary sensitivity and specificity of a given application in a user-friendly package that minimizes equipment. We review key work in the areas of fluidic controls for automation in paper-based devices, readout methods that minimize dedicated equipment, and power and heating methods that are compatible with low-resource point-of-care settings. We also highlight a focused set of recent applications and discuss future challenges.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Byrnes
authors.forename: Gregory
authors.initials: G
authors.lastname: Thiessen
authors.forename: Elain
authors.initials: E
authors.lastname: Fu
mesh_terms: D004867:Equipment Design; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D010209:Paper; D019095:Point-of-Care Systems