title: Coexistence of tuberous sclerosis complex and malignant melanoma.
abstract: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by widespread hamartomas in organs such as the skin, brain, heart, lung, liver and kidney. Although associations of TSC with hamartomas, angiomyolipomas and fibromas have been reported, there has been no report of its association with malignant melanoma. Herein, we describe a 31-year-old man with malignant melanoma associated with TSC. The patient had a history of epilepsia, multiple hypomelanotic macules, periungual fibromas and multiple hepatic lesions. Malignant melanoma was diagnosed by hepatic biopsy. To the best of our knowledge, this is the first report of malignant melanoma coexisting with TSC in the literature. We also present and discuss the imaging findings, prognosis, underlying mechanisms and practical approaches in relation to the disease.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, University of Cukurova, Saricam-Adana 01330, Turkey. meralgunaldi@gmail.com.
authors.forename: Meral
authors.initials: M
authors.lastname: Günaldi
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Cigdem Usul
authors.initials: CU
authors.lastname: Afsar
authors.forename: Figen
authors.initials: F
authors.lastname: Doran
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D035583:Rare Diseases; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D014402:Tuberous Sclerosis / Q000150:complications* / Q000175:diagnosis