title: Therapeutic drug monitoring as a component of personalized medicine: applications in pediatric drug development.
abstract: Therapeutic drug monitoring (TDM) is foundational to the concept of personalized medicine. TDM transformed drug therapy by affording the ability to characterize sources of variability in drug disposition and response to individualize drug dosing. Initially, TDM formed the key conceptual basis for personalized medicine, which has evolved to include pharmacogenomic and other biomarker-driven strategies for patient segmentation. Currently, TDM is an attractive option for personalized medicine and, under the right conditions, can facilitate drug development.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Momper
authors.affiliation: Merck, Whitehouse Station, New Jersey, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Wagner
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003663:Decision Trees; D055808:Drug Discovery / Q000379:methods*; D054796:Drug Dosage Calculations; D016903:Drug Monitoring / Q000379:methods*; D004358:Drug Therapy / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010372:Pediatrics / Q000379:methods*; D010597:Pharmacogenetics / Q000379:methods; D057285:Precision Medicine / Q000379:methods*