title: Microinvasive adenocarcinoma of the cervix in a young woman vaccinated against human papillomavirus: the screening must be continued.
abstract: OBJECTIVE
  This report describes a case that illustrates the limitations of the vaccination screening process for human papillomavirus (HPV) infection.
  
  
  METHODS
  We report an unexpected microinvasive adenocarcinoma of the cervix arising in a young woman vaccinated against HPV as part of a clinical trial 6 years previously and followed up annually by cytology. In January 2012, at age 23 years, the patient received a cytological result of atypical squamous cells, cannot exclude high-grade cervical squamous intraepithelial lesion, and colposcopy showed slight abnormalities. Biopsy revealed an adenocarcinoma in situ. Conization of the cervix was performed, and the diagnosis was microinvasive adenocarcinoma. Polymerase chain reaction and immunohistochemical study of conization material showed positivity for HPV-18 L1, p16, and Ki-67. Retrospective analysis of the clinical trial information revealed that 7 HPV tests had been performed, and all were positive for HPV-18, including the sample collected before the first vaccination.
  
  
  CONCLUSIONS
  HPV-18 was present in the cervix before vaccination. Persistent detection of HPV-18 should be considered an important factor in treatment planning. This case demonstrates the need to vaccinate women before their first sexual contact and highlights the need for keeping adequate screening even in vaccinated individuals.
authors.affiliation: 1Faculty of Medical Sciences, State University of Campinas, Campinas (SP); and 2Laboratory Bacchi, Botucatu (SP), Brazil.
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Teixeira
authors.forename: Sophie Françoise Mauricette
authors.initials: SF
authors.lastname: Derchain
authors.forename: Eliane R
authors.initials: ER
authors.lastname: Zambelli Oliveira
authors.forename: Círbia S
authors.initials: CS
authors.lastname: Campos Teixeira
authors.forename: Liliana A L A
authors.initials: LA
authors.lastname: Andrade
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Bacchi
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Zeferino
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000821:virology*; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006651:Histocytochemistry; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology*
chemical_list: D053918:Papillomavirus Vaccines