title: Surgical treatment of nasal polyposis: a comparison between cutting forceps and microdebrider.
abstract: BACKGROUND
  Nasal polyposis (NP) is defined as a specific form of chronic rhinosinusitis (CRS), characterized by bilateral and multifocal polyps. Functional endoscopic sinus surgery represents the gold standard therapy when medical treatment fails. The availability of different tools raises the question of which one provides significant advances in technique and surgical outcome. This study considered the outcome of the surgical treatment of NP in relation to several comorbidities and the surgical device used: the microdebrider versus the Blakesley traditional forceps. Other studies compared the two instruments but did not evaluate the clinical relevance of history of comorbidities such as asthma, allergy, and eosinophilia.
  
  
  METHODS
  A prospective randomized single-blind study was designed to analyze 311 cases of bilateral CRS with NP. Each patient served as his/her own control, meaning that one side was operated on using the Blakesley forceps and the opposite side using the microdebrider. The follow-up period was 13.3 ± 1.2 months.
  
  
  RESULTS
  The Blakesley forceps caused a significantly lower NP recurrence rate than the microdebrider (p < 0.001), which was more effective in preventing synechia formation (p < 0.05). Only asthma was significantly associated with a higher recurrence rate, without being influenced by the instrument used (p < 0.001).
  
  
  CONCLUSIONS
  The manual instrument allowed for a significantly lower recurrence incidence but yielded a higher rate of synechia formation compared with the microdebrider. Only asthma was significantly associated with a poorer clinical outcome, and gender, age, allergy, and eosinophilia did not affect the surgical prognosis.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Trieste, Trieste, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Tirelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Gatto
authors.forename: Giacomo
authors.initials: G
authors.lastname: Spinato
authors.forename: Margherita
authors.initials: M
authors.lastname: Tofanelli
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications; D003646:Debridement / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D016037:Single-Blind Method; D013525:Surgical Instruments