title: Elevated serum lactoferrin and neopterin are associated with postoperative infectious complications in patients with acute traumatic spinal cord injury.
abstract: BACKGROUND
  Several studies have shown that lactoferrin (LF) and neopterin (NT) are correlated with infection. The aim of this study is to determine whether serum levels of LF and NT are associated with postoperative infectious complications in patients with acute traumatic spinal cord injury.
  
  
  METHODS
  A total of 268 patients with acute traumatic spinal cord injury who underwent spinal surgery were enrolled in this study. Serum levels of LF, NT, and C-reactive protein (CRP), in addition to white blood cell count (WBC) and erythrocyte sedimentation rate (ESR), were measured preoperatively and 24 h postoperatively.
  
  
  RESULTS
  In total, 22 of 268 patients (8.2%) developed postoperative infectious complications. The levels of serum LF, NT, and CRP were significantly higher in the infected patients than in the non-infected patients. No significant differences were observed in postoperative WBC count and ESR between the two groups. Multivariate logistic regression revealed that LF (OR: 1.004 (1.002-1.007)), NT (OR: 1.137 (1.054-1.227)), and CRP (OR: 1.023 (1.002-1.044)) were significantly associated with the presence of postoperative infectious complications. The area under receiver operating characteristic curves for LF, NT, and CRP was 0.709, 0.779, and 0.629, respectively.
  
  
  CONCLUSIONS
  Elevated serum concentrations of LF and NT are associated with early infection after surgery. Compared to CRP, elevated levels of LF and NT are better indicators for predicting postoperative infectious complications in patients with acute traumatic spinal cord injury.
authors.affiliation: Department of Orthopedics, Nanning Second People's Hospital (Guangxi Medical University Third Affiliated Hospital), Naning, P.R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.forename: Chengshou
authors.initials: C
authors.lastname: Wei
authors.forename: Song
authors.initials: S
authors.lastname: Gu
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
keywords: acute traumatic spinal cord injury; lactoferrin; neopterin; postoperative infectious complications