title: Effects of CuDIPS and tween 80 on SJL/J tumorigenesis.
abstract: Plasma copper and zinc levels were measured in SJL/J mice, an inbred strain characterized by a high, spontaneous incidence of reticulum cell sarcoma (RCS). The changes with age in mean concentrations of these metals were consistent with a physiological response that is required for remission of neoplasia. Treatment of SJL/J mice with a copper complex, Cu(II)(3,4-diisopropylsalicylate)2 (Cu 3,5-DIPS), dissolved in a 10% Tween 80-saline solution revealed a decrease in survival and decline in the incidence of RCS at 52 wk of age. The toxic effects of Cu 3,5-DIPS therapy appeared to be related to the intraperitoneal route of administration and to extracellular deposition of collagen. The inhibitory effect on tumor development was not related to Cu 3,5-DIPS. Rather, Tween 80 was found to be the factor of importance.
authors.affiliation: Department of Biology, University of Alabama at Birmingham, University Station, 35294, Birmingham, Alabama.
authors.forename: C G
authors.initials: CG
authors.lastname: Crispens
authors.forename: P S
authors.initials: PS
authors.lastname: Porter
authors.forename: J R
authors.initials: JR
authors.lastname: Sorenson