title: Design, generation, and synthetic application of borylzincate: borylation of aryl halides and borylzincation of benzynes/terminal alkyne.
abstract: Borylzincate was generated in situ from dialkylzinc, diboron, and metal alkoxide. Model DFT calculations showed that although the formation of borylzincate is kinetically favorable, it is thermodynamically unfavorable. Therefore, we designed a successive reaction sequence that would provide a compensating energy gain. This enabled Zn-catalyzed borylation of aryl halides and borylzincation of benzynes and terminal alkyne from diborons without the need for any cocatalyst.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Ryo
authors.initials: R
authors.lastname: Takita
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hirano
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uchiyama
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D007700:Kinetics
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D001896:Boron Compounds; D006219:Halogens; C524146:benzyne