title: Psychiatric presentation of sporadic Creutzfeldt-Jakob disease: a challenge to current diagnostic criteria.
abstract: Pathological diagnosis remains the gold standard for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD), but being able to differentiate between CJD and non-prion diseases clinically is important because many of the non-prion, rapidly progressive dementias are treatable. Diagnostic criteria need both high sensitivity and specificity while remaining applicable to clinical practice. Despite extensive updates to the clinical criteria for sCJD, there remains a heavy emphasis on neurological signs. We describe a psychiatric presentation of sCJD that did not fulfill the diagnostic criteria until very late in a prolonged disease course and required biopsy for diagnosis.
authors.forename: Rehiana
authors.initials: R
authors.lastname: Ali
authors.forename: Atik
authors.initials: A
authors.lastname: Baborie
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Larner
authors.forename: Richard
authors.initials: R
authors.lastname: White
mesh_terms: D000368:Aged; D001526:Behavioral Symptoms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D005260:Female; D006801:Humans