title: Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines.
abstract: A copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence of K2CO3, a catalytic amount of CuCl2·2H2O, bipyridine, and oxygen (1 atm), allows the rapid assembly of N,N',N″-trisubstituted aryl guanidines.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, Laboratoire International Associé, CNRS , 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Jihui
authors.initials: J
authors.lastname: Li
authors.forename: Luc
authors.initials: L
authors.lastname: Neuville
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D006146:Guanidines; D003300:Copper