title: Limonoids from Aphanamixis polystachya and their antifeedant activity.
abstract: Eight new aphanamixoid-type aphanamixoids (C-J, 1-8) and six new prieurianin-type limonoids, aphanamixoids K-P (9-14), along with 10 known terpenoids were isolated from Aphanamixis polystachya, and their structures were established by spectroscopic data analysis. Among the new limonoids, 13 compounds exhibited antifeedant activity against the generalist Helicoverpa armigera, a plant-feeding insect, at various concentration levels. In particular, compounds 1, 4, and 5 showed potent activities with EC50 values of 0.017, 0.008, and 0.012 μmol/cm(2), respectively. On the basis of a preliminary structure-activity relationship analysis, some potential active sites in the aphanamixoid-type limonoid molecules are proposed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
authors.forename: Jie-Yun
authors.initials: JY
authors.lastname: Cai
authors.forename: Duo-Zhi
authors.initials: DZ
authors.lastname: Chen
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Luo
authors.forename: Ning-Chuan
authors.initials: NC
authors.lastname: Kong
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Hua
authors.forename: Shu-Xi
authors.initials: SX
authors.lastname: Jing
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
mesh_terms: D000465:Algorithms; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D007814:Larva / Q000187:drug effects; D007915:Lepidoptera / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D018411:Spodoptera / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins; C105838:prieurianin