title: Change of phase-solubility behavior by gamma-cyclodextrin derivatization.
abstract: The effect of γ-cyclodextrin and its four derivatives on the solubility of progesterone in phosphate buffer pH 7.4 was investigated. γ-Cyclodextrin forms a complex precipitating from solution at low cyclodextrin concentrations. No precipitation of complexes was observed with the γ-cyclodextrin derivatives. This change in phase-solubility behavior is probably due to low crystallization tendencies of the derivatives.
authors.affiliation: Department of Pharmaceutics, Christian-Albrechts-University, Gutenbergstraβe 76-78, D-2300, Kiel, FRG.
authors.forename: B W
authors.initials: BW
authors.lastname: Müller
authors.forename: U
authors.initials: U
authors.lastname: Brauns