title: A survey of phthalates and parabens in personal care products from the United States and its implications for human exposure.
abstract: Despite the widespread usage of phthalates and parabens in personal care products (PCPs), little is known about concentrations and profiles as well as human exposure to these compounds through the use of PCPs. In this study, nine phthalates and six parabens were determined in 170 PCPs (41 rinse-off and 109 leave-on), including 20 baby care products collected from Albany, New York. Phthalates were less frequently found in rinse-off PCPs but were more frequently found in perfumes (detection frequency of 100% for diethyl phthalate [DEP], 67% for dibutyl phthalate [DBP]), skin toners (90% for DEP), and nail polishes (90% for DBP). Parabens were found in ∼40% of rinse-off products and ∼60% of leave-on products. The highest concentrations of DEP, DBP, methyl- (MeP), ethyl- (EtP), propyl- (PrP), and butyl parabens (BuP) were on the order of 1000 μg per gram of the product. On the basis of amount and frequency of use of PCPs and the measured median concentrations of target analytes, the total dermal intake doses (sum of all phthalates or parabens) were calculated to be 0.37 and 31.0 μg/kg-bw/day for phthalates and parabens, respectively, for adult females. The calculated dermal intake of phthalates from PCPs was lower for infants and toddlers than for adult females. In contrast, dermal intake of parabens from PCPs by infants and toddlers was higher than that for adult females. The calculated maximum daily exposure dose of MeP, EtP, and PrP from PCPs ranged between 58.6 and 766 μg/kg-bw/day for infants and toddlers, which was 3 times higher than that calculated for adult females. PCPs are an important source of human exposure to parabens; the contribution of PCPs to phthalate exposure is low, except for DEP.
authors.affiliation: Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany , Empire State Plaza, P.O. Box 509, Albany, New York 12201-0509, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
mesh_terms: D000328:Adult; D002675:Child, Preschool; D003358:Cosmetics / Q000737:chemistry*; D003625:Data Collection; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D009518:New York; D010226:Parabens / Q000032:analysis*; D010795:Phthalic Acids / Q000032:analysis*; D012869:Skin Absorption
chemical_list: D003358:Cosmetics; D010226:Parabens; D010795:Phthalic Acids; C032279:phthalic acid