title: Influence of acetylsalicylic acid on hematotoxicity of benzene.
abstract: OBJECTIVE
  The aim of the study was to evaluate the influence of acetylsalicylic acid (ASA) on benzene hematotoxicity in rats.
  
  
  METHODS
  The study was carried out on rats exposed for 2, 4 and 8 weeks to benzene vapour at a concentration of 1.5 or 4.5 mmol/m(3) of air (5 days per week, 6 hours per day) alone or together with ASA at the doses of 5, 150 or 300 mg/kg body weight (per os).
  
  
  RESULTS
  Benzene at a concentration of 4.5 mmol/m(3) caused a slight lymphopenia, granulocytosis and reticulocytosis in blood. In bone marrow traits of megaloblastic renewal, presence of undifferentiated cells and giant forms of granulocytes as well as an increase in myeloperoxidase and decrease in chloroacetate esterase activity and lipids content were noted. ASA (150 and 300 mg/kg b.w.) influenced some of hematological parameters, altered by benzene intoxication. ASA limited the solvent-induced alteration in blood reticulocyte count and in the case of bone marrow in the erythroblasts count. Traits of megaloblastic renewal in bone marrow were less pronounced. Besides, higher activity of myeloperoxidase and the decrease in the level of lipids in granulocytes were noted.
  
  
  CONCLUSIONS
  Our results suggest that ASA limited the benzene-induced hematotoxicity.
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland, jzawieja@ump.edu.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kowalówka-Zawieja
authors.forename: Barbara
authors.initials: B
authors.lastname: Zielińska-Psuja
authors.forename: Jędrzej
authors.initials: J
authors.lastname: Przystanowicz
authors.forename: Karina
authors.initials: K
authors.lastname: Sommerfeld
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001554:Benzene / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006402:Hematologic Diseases / Q000097:blood* / Q000139:chemically induced* / Q000201:enzymology; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017701:Reticulocyte Count
chemical_list: D016861:Cyclooxygenase Inhibitors; D009195:Peroxidase; D002265:Carboxylic Ester Hydrolases; C019873:chloroacetate esterase; D001554:Benzene; D001241:Aspirin