title: Preparation of magnetic dummy molecularly imprinted polymers for selective extraction and analysis of salicylic acid in Actinidia chinensis.
abstract: Compounds with strong intramolecular hydrogen bonds (e.g., salicylic acid) have weak intermolecular hydrogen bonding interactions between them and functional monomers in the imprinting process. Consequently, the corresponding molecularly imprinted polymers (MIPs) have no specific adsorption ability. Here, the first magnetic dummy MIPs (MDMIPs) based on benzonic acid as dummy template are successfully developed and evaluated with respect to the applications in selective enrichment and analysis of salicylic acid from complex mixtures. Various parameters affecting absorption/desorption were evaluated for achieving optimal recovery and reducing nonspecific interactions. The prepared MDMIPs showed high adsorption capacity, good selectivity, rapid kinetic binding (40 min) and magnetic separation (5 s), high reproducibility (RSD< 4 % for batch-to-batch evaluation), and stability (only 4 % decrease after 6 cycles). Owing to the efficacy in specific binding and removal of interference, trace level salicylic acid was quantified (0.2 μg/g of fresh mass) in Actinidia chinensis by high-performance liquid chromatography.
authors.affiliation: School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
authors.forename: Qing-Ping
authors.initials: QP
authors.lastname: You
authors.forename: Mi-Jun
authors.initials: MJ
authors.lastname: Peng
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Zhang
authors.forename: Jun-Fang
authors.initials: JF
authors.lastname: Guo
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Shi
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D019817:Benzoic Acid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006860:Hydrogen Bonding; D008280:Magnetics; D054802:Molecular Imprinting; D015203:Reproducibility of Results; D020156:Salicylic Acid / Q000032:analysis / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D019817:Benzoic Acid; D020156:Salicylic Acid