title: A cure for AIDS: a matter of timing?
abstract: Despite the huge clinical success of antiretroviral therapy, several factors such as side effects, requirement of life-long adherence, high cost, incomplete access to therapies and development of drug resistance make the quest for an ultimate cure of HIV/AIDS a worldwide priority of biomedical research. In this respect, several sterilizing or functional cures have been reported in the last years in both non-human primates and humans. This review provides a summary of the main results achieved so far, outlining their strengths as well as their limitations. A synthetic interpretation of these results could be pivotal in order to develop an effective and widely available cure.
authors.forename: Iart Luca
authors.initials: IL
authors.lastname: Shytaj
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome 00161, Italy. andrea.savarino@iss.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Savarino
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001691:Biological Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D060740:Disease Eradication; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007167:Immunotherapy / Q000379:methods*
chemical_list: D019380:Anti-HIV Agents