title: Different vaccination strategies in Spain and its impact on severe varicella and zoster.
abstract: Varicella vaccines available in Spain were marketed in 1998 and 2003 for non-routine use. Since 2006 some regions decided to include varicella vaccination in their regional routine vaccination programmes at 15-18 months of age. Other regions chose the strategy of vaccinating susceptible adolescents. This study shows the trends in severe varicella zoster virus infections through the analysis of the hospital discharges related to varicella and herpes zoster in the general population from 2005 to 2010 in Spain. A total of 11,125 hospital discharges related to varicella and 27,736 related to herpes zoster were reported during the study period. The overall annual rate of hospitalization was 4.14 cases per 100,000 for varicella and 10.33 cases per 100,000 for herpes zoster. In children younger than 5 years old varicella hospitalization rate significantly decreased from 46.77 in 2005 to 26.55 per 100,000 in 2010. The hospitalization rate related to herpes zoster slightly increased from 9.71 in 2005 to 10.90 per 100,000 in 2010. This increase was mainly due to the significant increase occurring in the >84 age group, from 69.55 to 97.68 per 100,000. When gathering for regions taking into account varicella vaccine strategy, varicella related hospitalizations decreased significantly more in those regions which included the vaccine at 15-18 months of age as a routine vaccine comparing with those vaccinating at 10-14 years old. No significant differences were found in herpes zoster hospitalization rates regarding the varicella vaccination strategy among regions. Severe varicella infections decreased after implementation of varicella vaccination in Spain. This decrease was significantly higher in regions including the vaccine at 15-18 months of age compared with those vaccinating susceptible adolescents.
authors.affiliation: Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain; Department of Population Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: ruth.gil@urjc.es.
authors.forename: Ruth
authors.initials: R
authors.lastname: Gil-Prieto
authors.affiliation: Department of Social and Behavioural Sciences, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Walter
authors.affiliation: Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Gonzalez-Escalada
authors.affiliation: Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Garcia-Garcia
authors.affiliation: Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Marín-García
authors.affiliation: Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Gil-de-Miguel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006562:Herpes Zoster / Q000453:epidemiology* / Q000517:prevention & control; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D017589:Immunization Programs / Q000639:trends*; D007115:Immunization Schedule; D007223:Infant; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D019433:Chickenpox Vaccine
keywords: Epidemiology; Herpes zoster; Hospitalizations; Spain; Vaccine; Varicella