title: [Diagnosis and treatment of 51 patients with pancreatic islet cell tumors].
abstract: OBJECTIVE
  To investigate the diagnosis and treatment of pancreatic islet cell tumors.
  
  
  METHODS
  Fifty-one patients with islet cell tumors treated in our department from January 1991 to April 2011 were included in this study. The data of clinical features, diagnosis and treatment were retrospectively analyzed.
  
  
  RESULTS
  Among the 51 cases, 38 cases showed typical Whipple's triad, and the other 13 cases were non-functional islet cell tumors. In these 13 cases, 5 patients had no specific clinical symptoms, and 8 patients had abdominal distending pain. The positive rates of imaging were: B-ultrasound 43.1%, multi-slice spiral CT 69.8%; MRI 62.5%, endoscopic ultrasonography (EUS) 64.7% (11/17), and intraoperative ultrasound (IOUS) 96.3%, the differences among them were statistically significant (P<0.05). All patients underwent surgical treatment. Postoperative pancreatic leakage happened in 6 cases. Finally all the patients recovered after effective external drainage, anti-infection treatment and nutritional support.
  
  
  CONCLUSIONS
  Intraoperative ultrasonography (IOUS) has a higher accuracy in the diagnosis of pancreatic islet cell tumors, compared with preoperative B-ultrasonography, CT, MRI, and endoscopic ultrasound (EUS). The most effective treatment of this disease is surgery.
authors.affiliation: Institute of General Surgery, General Hospital, Tianjin Medical University, Tianjin 300052, China.
authors.forename: Hao-peng
authors.initials: HP
authors.lastname: Gao
authors.forename: Zhi-xiang
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Zhen-song
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D057868:Anastomotic Leak / Q000209:etiology; D019160:Endosonography; D005260:Female; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D010180:Pancreatectomy / Q000009:adverse effects; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D012189:Retrospective Studies