title: Interferon-γ release assay in the diagnosis of laryngeal tuberculosis.
abstract: CONCLUSIONS
  The T-SPOT test for Mycobacterium tuberculosis infection (T-SPOT.TB) can be used for early diagnosis of laryngeal tuberculosis (TB).
  
  
  OBJECTIVE
  The incidence of TB is increasing on a global scale. Laryngeal TB is the most common extrapulmonary form of TB and its early diagnosis is still difficult. This study investigated the performance of the interferon-γ release assay in the diagnosis of laryngeal TB.
  
  
  METHODS
  A total of 83 patients with laryngeal neoplasms were confirmed to have laryngeal TB by pathology, acid-fast staining, and/or fluorescence quantitative PCR. In addition, 52 patients with vocal cord polyps were enrolled as the control group. Two groups underwent both T-SPOT.TB and tuberculin skin test (TST).
  
  
  RESULTS
  T-SPOT.TB was positive in 75 cases in the laryngeal TB group and 4 cases in the control group, showing a sensitivity of 90.3% (75/83) and a specificity of 92.3% (48/52). The TST was positive in 42 cases and 20 cases, respectively, in these two groups. Obviously, TST and T-SPOT.TB were significantly different in terms of sensitivity when applied for detection of laryngeal TB (p < 0.05).
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Nantong University , Nantong, Jiangsu , PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Fei
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Kehua
authors.initials: K
authors.lastname: Min
authors.forename: Jingbo
authors.initials: J
authors.lastname: Zhang
authors.forename: Chuanlian
authors.initials: C
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D059425:Interferon-gamma Release Tests; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000473:pathology; D011237:Predictive Value of Tests; D014374:Tuberculin Test; D014387:Tuberculosis, Laryngeal / Q000175:diagnosis* / Q000473:pathology; D014827:Vocal Cords / Q000473:pathology