title: Right ventricular failure after implantation of a continuous-flow left ventricular assist device: early haemodynamic predictors.
abstract: OBJECTIVE
  Right ventricular failure (RVF) is a significant complication after implantation of a left ventricular assist device. We aimed to identify haemodynamic changes in the early postoperative phase that predicted subsequent development of RVF in a cohort of HeartMate II (HMII) implanted patients.
  
  
  METHODS
  This was a single-centre observational study of consecutive placement of HMII devices at Rigshospitalet, Copenhagen. Preoperative data (right heart catheterization, biochemistry and clinical status) and postoperative readings from the first 72 h after implantation (haemodynamics, inotropic and vasoactive therapy) were included in the analysis. The data set was examined for significant differences between patients who developed RVF (RVF group, n = 11)-defined as need for inotropic or vasodilator therapy >14 days, nitric oxide therapy ≥ 48 h or right ventricular assist device therapy-and those who did not (non-RVF group, n = 22).
  
  
  RESULTS
  Preoperative right heart catheterization data were similar in the two groups. Immediately after HMII implantation, the increase in cardiac index (CI) was significantly larger in the non-RVF than in the RVF group (0.96 ± 0.8 vs 0.2 ± 0.5 L/min, respectively; P = 0.018), whereas right ventricular stroke work index (RVSWI) decreased significantly more in the RVF group (-4.3 ± 2.0 vs -0.9 ± 2.0 g m/m(2); P < 0.001). These differences were present in spite of the RVF group receiving larger doses of catecholaminergic agents (P = 0.034). Over the ensuing 72 h, the CI of the RVF group gradually approached that of the non-RVF group; concurrently, however, the differences in inotropic therapy were further enhanced. Pump settings were similar in the two groups.
  
  
  CONCLUSIONS
  The haemodynamic alterations characterizing RVF were present already immediately after HMII implantation. RVF development was not related to pump flow and settings.
authors.affiliation: Department of Cardiothoracic Anesthesiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Joakim
authors.initials: J
authors.lastname: Cordtz
authors.forename: Jens C
authors.initials: JC
authors.lastname: Nilsson
authors.forename: Peter B
authors.initials: PB
authors.lastname: Hansen
authors.forename: Kaare
authors.initials: K
authors.lastname: Sander
authors.forename: Peter S
authors.initials: PS
authors.lastname: Olesen
authors.forename: Søren
authors.initials: S
authors.lastname: Boesgaard
authors.forename: Finn
authors.initials: F
authors.lastname: Gustafsson
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000503:physiopathology; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018497:Ventricular Dysfunction, Right / Q000453:epidemiology / Q000503:physiopathology
keywords: HeartMate II; Left ventricular assist device; Postimplantation haemodynamics; Right ventricular failure