title: Preoperative serum visfatin levels and prognosis of breast cancer among Chinese women.
abstract: Visfatin is identified a pro-inflammatory cytokine and its serum level is increased in various cancers. This study aimed to evaluate the prognostic value of preoperative serum visfatin level in breast cancers. Preoperative serum visfatin levels of 248 patients with breast cancer and serum visfatin levels of 100 healthy individuals and 100 benign women controls were determined using enzyme-linked immunosorbent assay. Unfavorable outcome was defined as first local recurrence, distant metastasis, second primary cancer of another organ, or death from any cause. Disease-free survival was defined as the time between surgery and the date of unfavorable outcome whichever appeared first. Overall survival was defined from surgery to death for any cause. The association of serum visfatin level with outcomes including mortality, unfavorable outcome, disease-free survival and overall survival was investigated by univariate and multivariate analyses. Preoperative serum visfatin level was substantially higher in patients than in healthy subjects and benign controls respectively. Elevated preoperative serum level of visfatin was identified an independent predictor of mortality, unfavorable outcome, disease-free survival and overall survival. Receiver operating characteristic curve analysis showed that serum level visfatin had high predictive value for mortality and unfavorable outcome. Thus, our results suggest that high preoperative serum visfatin level is associated with poor patient outcomes as well as may play a role as prognostic biomarker in breast cancer survival.
authors.affiliation: Department of Surgery, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Li
authors.affiliation: Central Laboratory, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China. Electronic address: shaohuatang@126.com.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Tang
authors.affiliation: Department of Surgery, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China.
authors.forename: Xiao-Cong
authors.initials: XC
authors.lastname: Zhou
authors.affiliation: Department of Surgery, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China.
authors.forename: Ying-Hai
authors.initials: YH
authors.lastname: Ye
authors.affiliation: Central Laboratory, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China.
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Xu
authors.affiliation: Department of Surgery, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, China.
authors.forename: Ri-Zeng
authors.initials: RZ
authors.lastname: Li
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery; D002681:China; D016207:Cytokines / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D057234:Preoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Biomarker; Breast cancer; Prognosis; Visfatin