title: Prognostic significance of FRA expression in epithelial cancers using AQUA(®) technology.
abstract: OBJECTIVE
  Although agents that target FRA have advanced through clinical trials, comprehensive analyses of FRA expression in epithelial cancers compared with clinical variables and prognosis are limited.
  
  
  METHODS
  FRA expression was examined in non-small-cell lung cancer (NSCLC), ovarian cancer and endometrial cancer cohorts using AQUA(®) technology.
  
  
  RESULTS
  For the NSCLC cohort, FRA expression was significantly higher in adenocarcinoma samples (p < 0.001) than other histologies, and in females (p = 0.003) versus males. High FRA expression was significantly associated with better survival in NSCLC cases (p = 0.01) while significantly and independently associated with worse prognosis in endometrial (p < 0.001) and ovarian cancers (p < 0.001).
  
  
  CONCLUSIONS
  These studies confirm the prognostic value of FRA in multiple indications. The opposing prognostic effects observed may suggest differential biology.
authors.affiliation: Department of Diagnostics Development, Morphotek, Inc., 210 Welsh Pool Road, Exton, PA 19341, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: O'Shannessy
authors.forename: Mark
authors.initials: M
authors.lastname: Gustavson
authors.forename: Lakshmi Krupa
authors.initials: LK
authors.lastname: Chandrasekaran
authors.forename: Marisa
authors.initials: M
authors.lastname: Dolled-Filhart
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Somers
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D005260:Female; D058975:Folate Receptor 1 / Q000276:immunology / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D058975:Folate Receptor 1