title: Electrocardiogram frequency change by extracorporeal blood perfusion in a swine ventricular fibrillation model.
abstract: BACKGROUND
  Extracorporeal cardiopulmonary resuscitation (ECPR) refers to the application of extracorporeal blood circulation with oxygenation as a resuscitation tool. The objective of this study is to observe the frequency component changes in the electrocardiogram (ECG) by ECPR during prolonged ventricular fibrillation (VF).
  
  
  METHODS
  Six swine were prepared as a VF model. Extracorporeal blood circulation with a pulsatile blood pump and oxygenator was set up for the model. ECG signals were measured for 13 min during VF and analyzed using frequency analysis methods. The median frequency (MF), dominant frequency (DF), and amplitude spectrum area (AMSA) were calculated from a spectrogram obtained using short-time Fourier transform (STFT).
  
  
  RESULTS
  MF decreased from 11 Hz at the start to 9 Hz at 2 min after VF and then increased to 11 Hz at 4.5 min after VF. DF started at 7 Hz and increased to 11 Hz within the first min and decreased to 9 Hz at 2 min, then increased to 12 Hz at 4.5 min after VF. Both frequency components decreased gradually from 4.5 min until 10 min after VF. After the oxygenated blood perfusion was initiated, both MF and DF increased remarkably and exceeded 12 and 14 Hz, respectively. Similarly, AMSA decreased gradually for the first 10 min, but increased remarkably and varied beyond 13 mV∙Hz after the oxygenated blood supply started. Remarkable frequency increases in ECG due to the oxygenated blood perfusion during ECPR were observed in the swine VF model.
  
  
  CONCLUSIONS
  The ECG frequency analysis during ECPR can give the resuscitation provider important information about the cardiac perfusion status and the appropriateness of the ECPR setup as well as the prediction of defibrillation success.
authors.affiliation: Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Yongon-dong 28, Jongro-gu, Seoul 110-744, Republic of Korea. ljch@snu.ac.kr.
authors.forename: Jung Chan
authors.initials: JC
authors.lastname: Lee
authors.forename: Gil Joon
authors.initials: GJ
authors.lastname: Suh
authors.forename: Hee Chan
authors.initials: HC
authors.lastname: Kim
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004562:Electrocardiography; D010100:Oxygen / Q000378:metabolism; D010477:Perfusion; D012815:Signal Processing, Computer-Assisted; D013552:Swine; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D010100:Oxygen