title: Triterpenoids and steroids from Ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release.
abstract: The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
authors.affiliation: Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam. tswu@mail.ncku.edu.tw.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Nguyen Thi Bich
authors.initials: NT
authors.lastname: Ngoc
authors.forename: Tran Thi Ngoc
authors.initials: TT
authors.lastname: Han
authors.forename: Chi-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism*; D013256:Steroids / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry*; D055815:Young Adult
chemical_list: D013256:Steroids; D014315:Triterpenes; D013481:Superoxides; D010196:Pancreatic Elastase