title: Methotrexate nephrotoxicity: Novel treatment, new approach.
abstract: This is the report of a case of methotrexate nephrotoxicity for which glucarpidase was used. We use the case to review a number of teaching points related to this new treatment option.
authors.affiliation: Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Saima
authors.initials: S
authors.lastname: Iqbal
authors.forename: Avan
authors.initials: A
authors.lastname: Armaghani
authors.forename: Ravi
authors.initials: R
authors.lastname: Aiyer
authors.forename: Amir
authors.initials: A
authors.lastname: Kazory
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011623:gamma-Glutamyl Hydrolase / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate
keywords: Methotrexate; Voraxaze; carboxypeptidase G2; glucarpidase; nephrotoxicity