title: Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach.
abstract: Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.
authors.affiliation: Department of Industrial Chemistry "Toso Montanari", School of Science, University of Bologna, V. Risorgimento 4, 40136, Bologna, Italy. mariafrancesca.fochi@unibo.it luca.bernardi2@unibo.it.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Caruana
authors.forename: Mariafrancesca
authors.initials: M
authors.lastname: Fochi
authors.forename: Mauro Comes
authors.initials: MC
authors.lastname: Franchini
authors.forename: Silvia
authors.initials: S
authors.lastname: Ranieri
authors.forename: Andrea
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi