title: Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway.
abstract: Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Walsh
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Allyson K
authors.initials: AK
authors.lastname: Friedman
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Haosheng
authors.initials: H
authors.lastname: Sun
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Heller
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Stacy M
authors.initials: SM
authors.lastname: Ku
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Juarez
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Veronica L
authors.initials: VL
authors.lastname: Burnham
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Mazei-Robison
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Deveroux
authors.initials: D
authors.lastname: Ferguson
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Sam A
authors.initials: SA
authors.lastname: Golden
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Ja Wook
authors.initials: JW
authors.lastname: Koo
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Dipesh
authors.initials: D
authors.lastname: Chaudhury
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Christoffel
authors.affiliation: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Pomeranz
authors.affiliation: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Friedman
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Russo
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Nestler
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Ming-Hu
authors.initials: MH
authors.lastname: Han
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D001549:Benzamides / Q000494:pharmacology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D000075402:Channelrhodopsins; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism* / Q000494:pharmacology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D007398:Interpersonal Relations; D008164:Luminescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008845:Microinjections; D009474:Neurons / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000166:cytology / Q000378:metabolism*; D062308:Optogenetics; D010446:Peptide Fragments / Q000494:pharmacology; D010775:Photic Stimulation; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics; D017557:Ventral Tegmental Area / Q000166:cytology / Q000378:metabolism*
chemical_list: C559317:ANA 12 compound; D001381:Azepines; D001426:Bacterial Proteins; D001549:Benzamides; D019208:Brain-Derived Neurotrophic Factor; D000075402:Channelrhodopsins; D004791:Enzyme Inhibitors; D008164:Luminescent Proteins; D010446:Peptide Fragments; C054562:yellow fluorescent protein, Bacteria; D003346:Corticotropin-Releasing Hormone; C045089:corticotropin releasing hormone (9-41); D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine