title: Thermal decomposition of thonzonium bromide.
abstract: Thonzonium bromide, a quaternary ammonium compound used as a surface active agent in a phenylephrine nasal solution, gave a gas chromatographic peak which was proportional in height and area to its concentration. Quaternary ammonium salts are nonvolatile and polar, thus the peak was attributed to a thermal decomposition product. It was identified as hexadecyldimethylamine by spectroscopic analysis and comparison with an authentic sample. A second product was identified by mass spectroscopy as 2[(2-hexadecylmethylaminoethyl)(4-methoxybenzylamino)] pyrimidine, the desmethyl bromide product. These decomposition products were detected in stability samples of formulations.
authors.affiliation: Product Development Laboratories, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950.
authors.forename: L
authors.initials: L
authors.lastname: Chafetz
authors.forename: R C
authors.initials: RC
authors.lastname: Greenough
authors.forename: J
authors.initials: J
authors.lastname: Frank