title: [Improvement of the knowledge on allergic cross-reactions between two drug groups: beta-lactams and NSAIDS].
abstract: OBJECTIVE
  To identify opportunities for improving the available knowledge of health care professionals (particularly, physicians, pharmacists, and nurses) on crossed allergic reactions (CAR) to penicillins and NSAIDs.
  
  
  METHODS
  Quasi-experimental prospective pre-exposure study at a 412-beds hospital. An assessment of the knowledge on CAR to penicillins and NSAIDs was performed by means of anonymous questionnaires before (1st questionnaire) and after (2d questionnaire) the implementation of a series of improvement measures: protocol of "patient allergic to drugs", pocket card, poster with summarized information, and informative talks. The questionnaires served as the CRF and the statistical analysis was done with the SPSS v18.0 software.
  
  
  RESULTS
  The mean number of errors in the first questionnaire on CARs of penicillin allergic patient and on CARs of NSAIDs allergic patients was 20.53 and 27.62, respectively. The mean number of errors in the second questionnaire on CARs of penicillin allergic patient and on CARs of NSAIDs allergic patients was 2.27 and 7.26, respectively. All the results were significant for a p level < 0.005.
  
  
  CONCLUSIONS
  - There is insufficient knowledge on CARs to penicillins and NSAIDS, which justifies improvement measures. - After the implementation of improvement measures, there is an increased knowledge on CARs to penicillins and NSAIDs in the study groups.
authors.affiliation: Hospital Morales Meseguer (Servicio Farmacia). Murcia.
authors.forename: I
authors.initials: I
authors.lastname: Sánchez-Quiles
authors.forename: M D
authors.initials: MD
authors.lastname: Nájera-Pérez
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Calleja-Hernández
authors.forename: F
authors.initials: F
authors.lastname: Martinez-Martínez
authors.forename: J
authors.initials: J
authors.lastname: Belchí-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Canteras
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D010406:Penicillins / Q000009:adverse effects; D011795:Surveys and Questionnaires; D047090:beta-Lactams / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010406:Penicillins; D047090:beta-Lactams