title: Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing.
abstract: Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina.
authors.forename: Micaela Giuliana
authors.initials: MG
authors.lastname: Goldschmidt
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Argentine National Council of Scientific and Technological Research (CONICET), Mendoza, Argentina.
authors.forename: Mirta Fabiana
authors.initials: MF
authors.lastname: Villarreal
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina; Argentine National Council of Scientific and Technological Research (CONICET), Mendoza, Argentina.
authors.forename: Delfina
authors.initials: D
authors.lastname: de Achával
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina.
authors.forename: Lucas Javier
authors.initials: LJ
authors.lastname: Drucaroff
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina.
authors.forename: Elsa Yolanda
authors.initials: EY
authors.lastname: Costanzo
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina; Argentine National Council of Scientific and Technological Research (CONICET), Mendoza, Argentina.
authors.forename: Mariana Nair
authors.initials: MN
authors.lastname: Castro
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina.
authors.forename: Jaime
authors.initials: J
authors.lastname: Pahissa
authors.affiliation: Laboratory for Neuropsychiatry & Neuromodulation, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Joan
authors.initials: J
authors.lastname: Camprodon
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL, United States.
authors.forename: Charles
authors.initials: C
authors.lastname: Nemeroff
authors.affiliation: FLENI Cognitive Neurology and Psychiatry, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina; Argentine National Council of Scientific and Technological Research (CONICET), Mendoza, Argentina; Department of Neurophysiology, University of Buenos Aires School of Psychology, Buenos Aires, Argentina. Electronic address: sguinjoan@fleni.org.ar.
authors.forename: Salvador Martín
authors.initials: SM
authors.lastname: Guinjoan
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D004644:Emotions / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010554:Personality Disorders / Q000150:complications; D010555:Personality Inventory; D010775:Photic Stimulation; D011618:Psychotic Disorders / Q000150:complications; D012559:Schizophrenia / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D035781:Siblings; D012919:Social Behavior; D064414:Type B Personality
keywords: Cluster B; Personality; Schizophrenia; Siblings; Temporo parietal junction; fMRI