title: [Myeloperoxidase in the neurodegenerative process of Parkinson's disease].
abstract: Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that MPO, as well as a biomarker for MPO - 3-Chlorotyrosine - are upregulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model of Parkinson's disease as well as in the disease itself. Ablation of MPO resulted in a neuroprotective effect in the MPTP-model. Herein we describe the different function of MPO, and how these can lead to the cellular demise as seen in Parkinson's disease.
authors.affiliation: School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
authors.forename: P
authors.initials: P
authors.lastname: Teismann
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000473:pathology / Q000502:physiology; D002452:Cell Count; D004298:Dopamine / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology / Q000502:physiology; D018836:Inflammation Mediators / Q000097:blood; D051379:Mice; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology*; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology*; D020734:Parkinsonian Disorders / Q000473:pathology / Q000503:physiopathology; D009195:Peroxidase / Q000502:physiology*; D017382:Reactive Oxygen Species; D013378:Substantia Nigra / Q000473:pathology / Q000503:physiopathology
chemical_list: D005609:Free Radicals; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D009195:Peroxidase; D004298:Dopamine