title: Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women.
abstract: We evaluated whether serum omentin levels are associated with coronary artery disease (CAD) and its severity among postmenopausal women. We enrolled 193 consecutive postmenopausal women who had undergone coronary angiography for suspected stable CAD. The study population was divided into 2 groups based on the results of coronary angiography (CAD group, n=110 and control group, n=83). Omentin 1 levels were measured and disease severity was assessed using the SYNTAX score (SS) in the CAD group. Those patients with angiographic CAD had significantly decreased omentin 1 levels, compared to those without CAD (247.5+127.4 vs 506+246 ng/mL, P<.001). After adjusting for cardiovascular risk factors, a decreased omentin 1 level was found to be an independent predictor of both angiographic CAD and a high SS. Our data indicate that a decreased omentin 1 level is associated with CAD and its severity among postmenopausal women.
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Imran
authors.initials: I
authors.lastname: Onur
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey fahrettin_oz@hotmail.com.
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Oz
authors.affiliation: Cardiology Clinic, Bagcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Sezai
authors.initials: S
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Oflaz
authors.affiliation: Cardiology Clinic, Bagcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Sigirci
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Elitok
authors.affiliation: Department of Biochemistry, Bagcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Saadet
authors.initials: S
authors.lastname: Pilten
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ekrem Bilal
authors.initials: EB
authors.lastname: Karaayvaz
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ahmet Y
authors.initials: AY
authors.lastname: Cizgici
authors.affiliation: Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Mehmet G
authors.initials: MG
authors.lastname: Kaya
authors.affiliation: Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Seda Tural
authors.initials: ST
authors.lastname: Onur
authors.affiliation: Cardiology Clinic, Bagcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Sahin
authors.affiliation: Cardiology Clinic, Bagcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Hakan M
authors.initials: HM
authors.lastname: Dinckal
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D011237:Predictive Value of Tests; D011859:Radiography; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: adipose tissue; coronary artery disease; inflammation; omentin 1; postmenopausal women; syntax score