title: A new 3,4-seco-labdane diterpenoid with inhibitory activity against the production of nitric oxide from the leaves of Callicarpa nudiflora.
abstract: A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1) exerted inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by lipopolysaccharide.
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Guo-Yu
authors.initials: GY
authors.lastname: Li
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C587224:3,4-seco-12R,13S-dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C433017:labdane; D009569:Nitric Oxide