title: Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.
abstract: Btk is the protein affected in XLA, a disease identified as a B cell differentiation defect. Btk is crucial for B cell differentiation and activation, but its role in other cells is not fully understood. This review focuses on the function of Btk in monocytes, neutrophils, and platelets and the receptors and signaling cascades in such cells with which Btk is associated.
authors.affiliation: 1.Col. Insurgentes Cuicuilco, Torre de Investigación 9o. piso, Mexico, D.F., Mexico 04530. glopezh@pediatria.gob.mx.
authors.forename: Gabriela
authors.initials: G
authors.lastname: López-Herrera
authors.forename: Alexander
authors.initials: A
authors.lastname: Vargas-Hernández
authors.forename: Maria Edith
authors.initials: ME
authors.lastname: González-Serrano
authors.forename: Laura
authors.initials: L
authors.lastname: Berrón-Ruiz
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rodríguez-Alba
authors.forename: Francisco
authors.initials: F
authors.lastname: Espinosa-Rosales
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Santos-Argumedo
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000361:Agammaglobulinemia / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology* / Q000276:immunology*; D040181:Genetic Diseases, X-Linked / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D009154:Mutation / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism
chemical_list: D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human
keywords: TLRs; XLA; inflammation