title: Critical care issues in management of high-grade lymphoma.
abstract: Lymphoma presents itself from slow growing and asymptomatic to aggressive and destructive. Suspicion of aggressive lymphoma warrants prompt diagnostic evaluation because the tumor can be extremely fast growing and can cause significant sequelae including but not limited to tissue damage, immune suppression, organ failure, compromised circulation, and death. The standard evaluation includes laboratory assay, infectious disease panel, radiographic imaging with computed tomography, bone marrow biopsy, and tissue diagnosis. Two cases studies are presented describing the range of different acute issues that may arise with aggressive lymphomas including tumor lysis, HIV, small bowel obstruction, superior vena cava compression, aggressive disease transformation, and acute renal injury.
authors.affiliation: Nocturnal Program, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Unit 0379, Houston, TX 77030, USA. Electronic address: jkjohnson@mdanderson.org.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Johnson
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sorensen
mesh_terms: D000328:Adult; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002471:Cell Transformation, Neoplastic; D003422:Critical Care; D016638:Critical Illness; D018450:Disease Progression; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis
keywords: AIDS; Burkitt lymphoma; HIV; Inferior vena cava obstruction; Renal failure; Tumor lysis syndrome