title: Antibacterial activity of glucomoringin bioactivated with myrosinase against two important pathogens affecting the health of long-term patients in hospitals.
abstract: Glucosinolates (GLs) are natural compounds present in species of the order Brassicales and precursors of bioactive isothiocyanates (ITCs). In the recent years, they have been studied mainly for their chemopreventive as well as novel chemotherapeutics properties. Among them 4-(α-L-rhamnosyloxy)benzyl glucosinolate (glucomoringin; GMG), purified from seeds of Moringa oleifera Lam., a plant belonging to the Moringaceae family, represents an uncommon member of the GL family with peculiar characteristics. This short communication reports new evidences about the properties of GMG and presents a new innovative utilization of the molecule. The bioactivation of GMG by myrosinase enzyme just before treatment, permits to maximize the power of the final product of the reaction, which is the 4-(α-L-rhamnosyloxy)benzyl isothiocyanate (GMG-ITC). We tested the antibiotic activity of this latter compound on two strains of pathogens affecting the health of patients in hospital, namely Staphylococcus aureus and Enterococcus casseliflavus, and on the yeast Candida albicans. Results show that the sensibility of S. aureus BAA-977 strain and E. casseliflavus to GMG-ITC treatment reveals an important possible application of this molecule in the clinical care of patients, more and more often resistant to traditional therapies.
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, S.S.113, Contrada Casazza, Messina 98124, Italy. renato.iori@entecra.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Galuppo
authors.forename: Gina Rosalinda De
authors.initials: GR
authors.lastname: Nicola
authors.forename: Renato
authors.initials: R
authors.lastname: Iori
authors.forename: Pia
authors.initials: P
authors.lastname: Dell'utri
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Mazzon
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects; D005961:Glucosinolates / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005961:Glucosinolates; D006026:Glycoside Hydrolases; C022739:thioglucosidase