title: The interactions of nonalcoholic fatty liver disease and cardiovascular diseases.
abstract: A complex interaction among metabolic factors, adipose tissue lipolysis, oxidative stress, and insulin resistance results in a deleterious process that may link nonalcoholic fatty liver disease (NAFLD) with severe cardiovascular (CV) outcomes. Patients with NAFLD are at higher risk of atherosclerosis, new onset of CV events, and overall mortality. The strong association between NAFLD and CV disease should affect clinical practice, with screening and surveillance of patients with NAFLD. This review discusses the data linking these major diseases.
authors.affiliation: Hepatology Department, Liver Center, Groupe Hospitalier Pitié-Salpêtrière (GHPS), Assistance Publique Hôpitaux de Paris (APHP), 47-83, Boulevard de l'Hôpital, Paris 75013, France; Pierre et Marie Curie University (Paris 6), Inserm UMR_S 938, Paris, France.
authors.forename: Hugo
authors.initials: H
authors.lastname: Perazzo
authors.forename: Thierry
authors.initials: T
authors.lastname: Poynard
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dufour
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D016893:Carotid Stenosis / Q000150:complications; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008066:Lipolysis; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D058226:Plaque, Atherosclerotic / Q000150:complications; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified
keywords: Atherosclerosis; Cardiovascular disease; Insulin resistance; Liver fibrosis; Nonalcoholic fatty liver disease