title: Association between the CYP4A11 T8590C variant and essential hypertension: new data from Han Chinese and a meta-analysis.
abstract: OBJECTIVE
  CYP4A11 oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor and natriuretic in humans. Previous studies demonstrated an association between a functional variant (T8590C) of CYP4A11 and essential hypertension, though with conflicting results. To elucidate this relationship, a case-control study and meta-analysis were performed to assess the possible association of essential hypertension with CYP4A11 genetic variations.
  
  
  METHODS
  Associations between the T8590C polymorphism and essential hypertension were examined in 328 unrelated cases and 297 age-matched controls in Han Chinese individuals. High-resolution melting was used to identify the CYP4A11 variant. To further investigate the association, we conducted a meta-analysis including eight studies published previously in July 2012.
  
  
  RESULTS
  The frequency of the CYP4A11 T8590C polymorphism showed no significant difference between cases and controls (all P>0.05). However, the meta-analysis showed that the CYP4A11 T8590C polymorphism may increase the risk of essential hypertension in an additive model (OR: 1.15, 95% CI: 1.02-1.29, P = 0.02), a dominant model (OR: 1.06, 95% CI: 1.01-1.32, P = 0.03), a recessive model (OR: 1.52, 95% CI: 1.15-2.02, P = 0.003) and a homozygote contrast (OR: 1.38, 95% CI: 1.07-1.78, P = 0.01). Also, a significant relationship was observed among Caucasians in the additive model, the homozygote contrast, the recessive model and the dominant model (all P<0.05). However, no association was observed in an Asian population (all P>0.05).
  
  
  CONCLUSIONS
  This meta-analysis suggests there is a significant association between the CYP4A11 T8590C variant and essential hypertension, especially in Caucasians. The case-control study did not find a significant association among the Han Chinese population, but the controls were poorly matched and meaningful conclusions cannot therefore be made. Further large-scale studies are needed to clarify whether the CYP4A11 T8590C polymorphism is associated with hypertension risk in Asians or has a gender-specific effect.
authors.affiliation: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Hua-Cheng
authors.initials: HC
authors.lastname: Yan
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Bao-Xia
authors.initials: BX
authors.lastname: He
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Qiu
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Ding
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Shu-Jin
authors.initials: SJ
authors.lastname: Zhao
mesh_terms: D016022:Case-Control Studies; D002681:China; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D003577:Cytochrome P-450 Enzyme System; C465478:CYP4A11 protein, human; D042926:Cytochrome P-450 CYP4A