title: Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat.
abstract: Effects of low level lead (Pb) exposure on the time-dependent organ-tissue distribution of zinc (Zn), iron (Fe), copper (Cu), and calcium (Ca) were investigated in the neonatal rat. Pups were exposed to Pb acetate (50 mg/kg) via intragastric intubation at 3-d intervals from day 6 postpartum to day 18. This level of Pb exposure had no significant effect on body weight. Exposure to Pb resulted in an alteration of the normal, time-dependent organ distribution of the essential elements and significantly lower concentrations of Zn were found in brain, liver, kidney, and femur of Pb-treated animals.
authors.affiliation: Nutrition Program, College of Human Development, The Pennsylvania State University, University Park, 16801, Pennsylvania.
authors.forename: G D
authors.initials: GD
authors.lastname: Miller
authors.forename: T F
authors.initials: TF
authors.lastname: Massaro
authors.forename: E
authors.initials: E
authors.lastname: Koperek
authors.forename: E J
authors.initials: EJ
authors.lastname: Massaro