title: Microstructure, corrosion properties and bio-compatibility of calcium zinc phosphate coating on pure iron for biomedical application.
abstract: In order to improve the biocompatibility and the corrosion resistance in the initial stage of implantation, a phosphate (CaZn2(PO4)2·2H2O) coating was obtained on the surface of pure iron by a chemical reaction method. The anti-corrosion property, the blood compatibility and the cell toxicity of the coated pure iron specimens were investigated. The coating was composed of some fine phosphate crystals and the surface of coating was flat and dense enough. The electrochemical data indicated that the corrosion resistance of the coated pure iron was improved with the increase of phosphating time. When the specimen was phosphated for 30min, the corrosion resistance (Rp) increased to 8006 Ω. Compared with that of the naked pure iron, the anti-hemolysis property and cell compatibility of the coated specimen was improved significantly, while the anti-coagulant property became slightly worse due to the existence of element calcium. It was thought that phosphating treatment might be an effective method to improve the biocompatibility of pure iron for biomedical application.
authors.affiliation: State Key Lab of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Erlin
authors.initials: E
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
mesh_terms: D000818:Animals; D020811:Biomedical Technology; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D003343:Corrosion; D055664:Electrochemical Techniques; D007501:Iron / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D010710:Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D056951:Photoelectron Spectroscopy; D011817:Rabbits; D012996:Solutions; D013052:Spectrometry, X-Ray Emission; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D013499:Surface Properties; D014961:X-Ray Diffraction; D017967:Zinc Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D010710:Phosphates; D012996:Solutions; D017967:Zinc Compounds; C043952:zinc phosphate; D007501:Iron
keywords: Biomaterials; Coatings; Corrosion; Pure iron; Surfaces