title: PAS kinase: a nutrient sensing regulator of glucose homeostasis.
abstract: Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease.
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT.
authors.forename: Desiree
authors.initials: D
authors.lastname: DeMille
authors.forename: Julianne H
authors.initials: JH
authors.lastname: Grose
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D016415:Sequence Alignment; D013379:Substrate Specificity
chemical_list: C116037:PAS domain kinases; D017346:Protein Serine-Threonine Kinases; D005947:Glucose
keywords: PAS kinase; diabetes; glucose metabolism; nutrient sensing; obesity; signal transduction