title: Megabladder mouse model of congenital obstructive nephropathy: genetic etiology and renal adaptation.
abstract: Congenital obstructive nephropathy remains one of the leading causes of chronic renal failure in children. The direct link between obstructed urine flow and abnormal renal development and subsequent dysfunction represents a central paradigm of urogenital pathogenesis that has far-reaching clinical implications. Even so, a number of diagnostic, prognostic, and therapeutic quandaries still exist in the management of congenital obstructive nephropathy. Studies in our laboratory have characterized a unique mutant mouse line that develops in utero megabladder, variable hydronephrosis, and progressive renal failure. Megabladder mice represent a valuable functional model for the study of congenital obstructive nephropathy. Recent studies have begun to shed light on the genetic etiology of mgb (-/-) mice as well as the molecular pathways controlling disease progression in these animals.
authors.affiliation: Department of Pediatrics and Division of Anatomy, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA, Kirk.McHugh@nationwidechildrens.org.
authors.forename: Kirk M
authors.initials: KM
authors.lastname: McHugh
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006869:Hydronephrosis / Q000151:congenital* / Q000473:pathology*; D051379:Mice