title: Chemical constituents from an endophytic fungus Chaetomium globosum Z1.
abstract: A new ergosterol, 15beta-hydroxyl-(22E,24R)-ergosta-3, 5, 8, 22-tetraen-one (1), along with three known ergosterols, two known cytochalasins, and two known azapholines were isolated from Chaetomium globosum Z1. The structures of these compounds were elucidated on the basis of spectroscopic methods (HR-ESI-MS, 1D NMR, and 2D NMR). Compound 6 showed significant cytotoxic activity against A-549 and MG-63 cell lines with IC50 values of 6.96 and 1.73 microg/mL, respectively.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Ji
authors.forename: Xuan
authors.initials: X
authors.lastname: Gui
authors.forename: Bao-Kang
authors.initials: BK
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000737:chemistry*; D060026:Endophytes / Q000737:chemistry; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004875:Ergosterol