title: Regioselective synthesis of 4-substituted indoles via C-H activation: a ruthenium catalyzed novel directing group strategy.
abstract: A highly regioselective functionalization of indole at the C-4 position by employing an aldehyde functional group as a directing group, and Ru as a catalyst, under mild reaction conditions (open flask) has been uncovered. This strategy to synthesize 4-substituted indoles is important, as this class of privileged molecules serves as a precursor for ergot alkaloids and related heterocyclic compounds.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore-560012, Karnataka, India.
authors.forename: Veeranjaneyulu
authors.initials: V
authors.lastname: Lanke
authors.forename: Kandikere
authors.initials: K
authors.lastname: Ramaiah Prabhu
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D012428:Ruthenium