title: Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain.
abstract: Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.
authors.affiliation: Department of Chemistry, National Taiwan University , Taipei 10617, Taiwan.
authors.forename: Cheng-Hsun
authors.initials: CH
authors.lastname: Wu
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Chen
authors.forename: Si-Han
authors.initials: SH
authors.lastname: Wu
authors.forename: Yann
authors.initials: Y
authors.lastname: Hung
authors.forename: Chung-Yuan
authors.initials: CY
authors.lastname: Mou
authors.forename: Richard P
authors.initials: RP
authors.lastname: Cheng
mesh_terms: D001120:Arginine / Q000737:chemistry*; D004705:Endocytosis; D006367:HeLa Cells; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry*; D018613:Microscopy, Confocal; D053758:Nanoparticles; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D026901:Membrane Transport Proteins; D012822:Silicon Dioxide; D001120:Arginine; C043912:peptide permease