title: [Bioinformatics on new human adenoviruses causing nosocomial infection].
abstract: Human adenovirus (HAdV) causing epidemic keratoconjunctivitis is limited to D and E species. Recent progress in bioinformatics revealed that these viruses attach to the host with fibers, infiltrate the host cells via RGD (Arg-Gly-Asp) motif of penton base, and reveal their serological reaction by hexons. Loops 1 and 2 are the variable regions of each hexon. The possibility that a novel adenovirus later named HAdV-52 was transmitted over the wall of species' from monkeys to humans was reported. The recombination of the above three hot spots introduces novel types such as HAdV-53, -54, and -56. Boinformatics may provide rapid genotyping in nosocomial infection, predicting future epidemics, and an estimate of the therapeutic target molecules in the near future.
authors.affiliation: Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Japan. mdaoki2007@yahoo.co.jp
authors.forename: Koki
authors.initials: K
authors.lastname: Aoki
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Kaneko
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Hidemi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
mesh_terms: D000260:Adenoviruses, Human / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D019295:Computational Biology; D003428:Cross Infection / Q000821:virology*; D000882:Haplorhini; D006801:Humans; D007639:Keratoconjunctivitis, Infectious / Q000821:virology