title: Anti-Helicobactor pylori activity of some Jordanian medicinal plants.
abstract: BACKGROUND
  Natural flora are considered a major source of new agents for the treatment of Helicobactor pylori. The plants used in this study were selected based on previous traditional use.
  
  
  OBJECTIVE
  In this study, we evaluated the effect of extracts of 16 medicinal plants grown in Jordan against clinical isolates of H. pylori.
  
  
  METHODS
  Tested plant extracts included Aloysia triphylla (L'Her.) Britton (Verbenaceae), Anethum graveolens L. (Apiaceae), Artemisia inculata Delile (Asteraceae), Capparis spinosa L. (Capparaceae), Crataegus aronia (L.) Bosc ex. DC. (Rosaceae), Inula viscose (L.) Ait (Asteraceae), Lavandula officinalis Chaix. (Lamiaceae), Lepidium sativum L. (Cruciferae), Origanum syriaca L. (Lamiaceae), Paronychia argentea Lam. (Caryophyllaceae), Passiflora incarnate L. (Passifloraceae), Psidium guajava L. (Myrtaceae), Sarcopoterium spinosum (L.) Spach (Rosaceae), Sesamum indicum L. (Pedaliaceae), Urtica urens L. (Urticaceae) and Varthemia iphionoids Boiss (Asteraceae). Clinical isolates of H. pylori were tested in vitro for susceptibility to each of the above plant crude extracts using disk diffusion method, and the MIC value was determined for each plant extract using the serial dilution method.
  
  
  RESULTS
  Results showed that ethanol extracts of most medicinal plants exerted cytotoxiciy against H. pylori isolates. Among the tested plant extracts, A. triphylla (MIC: 90 µg/mL, MBC: 125 µg/mL) and I. viscosa (MIC: 83 µg/mL, MBC: 104 µg/mL) showed the strongest activity against both isolates of H. pylori.
  
  
  CONCLUSIONS
  Jordanian medicinal plants might be valuable sources of starting materials for the synthesis of new antibacterial agents against H. pylori.
authors.affiliation: Department of Pharmaceutical Technology .
authors.forename: Majed M
authors.initials: MM
authors.lastname: Masadeh
authors.forename: Ahmad S
authors.initials: AS
authors.lastname: Alkofahi
authors.forename: Karem H
authors.initials: KH
authors.lastname: Alzoubi
authors.forename: Haitham N
authors.initials: HN
authors.lastname: Tumah
authors.forename: Kamal
authors.initials: K
authors.lastname: Bani-Hani
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D007597:Jordan; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification / Q000254:growth & development; D012621:Seasons
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts