title: A rare case of short stature: Say Meyer syndrome.
abstract: BACKGROUND
  Say Meyer syndrome is rare X linked condition characterized by developmental delay, short stature and metopic suture synostosis. We are reporting a case of Say Meyer syndrome presented to our hospital for short stature and developmental delay at age 3½ years.
  
  
  METHODS
  A 3½-year-old boy presented to our hospital for decreased growth velocity from the age of 1 year. History revealed the boy had a birth weight of 2.3 kg, had an episode of seizures in the neonatal period. He was born to non-consanguineous marriage. He had global developmental delay and there was a lack of bowel and bladder control. History did not reveal any hearing or visual impairment. No history of any chronic systemic illnesses. Magnetic resonance imaging (MRI) brain revealed mild diffuse frontotemporal atrophy with multiple irregular gliotic areas in bilateral frontal lobes. Diffuse white matter volume loss in bilateral cerebral hemispheres. Diffuse thinning of corpus callosum. Diffuse periventricular hyper intensity on T2W and fluid attenuated inversion recovery sequences.
  
  
  CONCLUSIONS
  Say Meyer syndrome is rare X linked condition characterized by developmental delay, short stature and metopic suture synostosis. Characteristic MRI brain findings include diffuse frontotemporal atrophy with multiple gliotic areas in frontal lobes. Diffuse white matter volume loss in bilateral cerebral hemispheres.
authors.affiliation: Department of Endocrinology and Metabolism, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Karthik
authors.forename: N Rajendra
authors.initials: NR
authors.lastname: Prasad
authors.forename: P Radha
authors.initials: PR
authors.lastname: Rani
authors.forename: Rushikesh
authors.initials: R
authors.lastname: Maheshwari
authors.forename: P Amaresh
authors.initials: PA
authors.lastname: Reddy
authors.forename: B V S
authors.initials: BV
authors.lastname: Chakradhar
authors.forename: Bindu
authors.initials: B
authors.lastname: Menon
keywords: Craniosynostosis; Say Meyer syndrome; frontotemporal atrophy; multiple gliotic areas; short stature