title: Apralactone A and a New Stereochemical Class of Curvularins from the Marine-Derived FungusCurvulariasp.
abstract: Chemical investigations of the cytotoxic extract of the marine-derived fungusCurvulariasp. (strain no. 768), isolated from the red algaAcanthophora spicifera, yielded the novel macrolide apralactone A (1), as well as the antipodes of curvularin macrolides2-7. Compound8, a dimeric curvularin was recognised as an artefact. The structures of1-8were elucidated by interpretation of their spectroscopic data (1D and 2D NMR, CD, MS, UV and IR). Apralactone A (1) is a 14-membered phenyl acetic acid macrolactone, and the first such compound with a 4-chromanone substructure. Compounds1, 2, 4, 5and6were found to be cytotoxic towards human tumor cell lines with mean IC50values in the range of 1.25 to 30.06 µM.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Greve
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schupp
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Eguereva
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kelter
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Heinz-Herbert
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
keywords: Antitumor agents; Natural products; Polyketides; Structure elucidation