title: Structure of a Neurotoxin that Induces Parkinsonism Symptoms; l-Methyl-4-phenyl-l,2,3,6-tetra-hydropyridine Hydrochloride.
abstract: The X-ray crystal structure of the neurotoxin MPTP (l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has been elucidated. A comparison of the structural relationship of his agent, which induces Parkinsonism by the selective destruction of nigrostriatal dopamine neurons, to the crystal structure of dopamine is presented.
authors.affiliation: Department of Chemistry, Xavier University, New Orleans, Louisiana, 70125.
authors.forename: C L
authors.initials: CL
authors.lastname: Klein
authors.forename: R F
authors.initials: RF
authors.lastname: Borne
authors.forename: E D
authors.initials: ED
authors.lastname: Stevens