title: A general route to 1,3'-bipyrroles.
abstract: A general method is described for the synthesis of 1,3'-bipyrroles. The route involves constructing a pyrrole ring on the nitrogen of a substituted 1H-pyrrole, so as to generate the 1,3'-bipyrrole. In this approach the nitrogen of the starting pyrrole was alkylated with a special Michael acceptor having an allylic leaving group, and the product was then modified in such a way that the second pyrrole ring could be formed by a Paal-Knorr reaction. Two variants of this sequence were examined, one of which led to formation of a 3-hydroxypyridine instead of the second pyrrole ring; the other variant used phenacyl bromide instead of the special Michael acceptor.
authors.affiliation: Chemistry Department, University of Alberta , Edmonton, Alberta T6G 2G2, Canada.
authors.forename: Ping
authors.initials: P
authors.lastname: Cheng
authors.forename: Wenjie
authors.initials: W
authors.lastname: Shao
authors.forename: Derrick L J
authors.initials: DL
authors.lastname: Clive
mesh_terms: D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011758:Pyrroles