title: Intraoperative sRAGE kinetics. A new age-related outcome predictor of cardiac surgery.
abstract: BACKGROUND
  Glycated proteins (advanced glycation endproducts, AGE) in tissue are associated with degenerative diseases. This study evaluated the role of sRAGE (soluble receptor for advanced glycation endproducts), a decoy receptor of AGEs in blood, for the outcome of patients after coronary artery bypass grafting (CABG).
  
  
  METHODS
  A total of 90 patients undergoing CABG were analysed in two centres. Perioperative blood samples were collected before surgery up to 1 week postoperatively. sRAGE was measured by ELISA. Patients were subdivided regarding age (< 64 versus > 70 years, 14 % versus 35 % female), euroSCORE (< 3 versus > 4, 14 % versus 29 % female) and sRAGE changes between sternotomy and end of the operation (< 30 % versus > 45 %, 33 % versus 33 % female) and subsequently analysed with respect of postoperative outcome parameters.
  
  
  RESULTS
  Preoperative sRAGE values did not correlate with the outcome of the patients. sRAGE levels increase within 10 min from 1,539 ± 96 to 5,311 ± 187 pg/ml after sternotomy, then returning to baseline levels within 2 days after surgery. Comparing the analysed possible risk factors age, euroSCORE and sRAGE changes, no difference was observed regarding 30-day mortality. Age and the euroSCORE are superior with respect of tachyarrythmia, whereas sRAGE kinetics seems to be superior with respect of prolonged postoperative respiration time/stay in the intensive care unit or catecholamine support.
  
  
  CONCLUSIONS
  A prolonged, increased intraoperative sRAGE level is a new outcome predictor for patients undergoing CABG surgery, mutually complementary to the euroSCORE.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle, Germany, andreas.simm@medizin.uni-halle.de.
authors.forename: A
authors.initials: A
authors.lastname: Simm
authors.forename: C
authors.initials: C
authors.lastname: Philipp
authors.forename: I
authors.initials: I
authors.lastname: Friedrich
authors.forename: R J
authors.initials: RJ
authors.lastname: Scheubel
authors.forename: H-S
authors.initials: HS
authors.lastname: Hofmann
authors.forename: K H
authors.initials: KH
authors.lastname: Meibodi
authors.forename: A
authors.initials: A
authors.lastname: Sablotzki
authors.forename: R-E
authors.initials: RE
authors.lastname: Silber
authors.forename: J
authors.initials: J
authors.lastname: Börgermann
mesh_terms: D017677:Age Distribution; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass / Q000401:mortality*; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000706:statistics & numerical data; D017063:Outcome Assessment, Health Care / Q000379:methods*; D015995:Prevalence; D011379:Prognosis; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic