title: Simultaneous determination of tiaramide and its metabolites by high performance liquid chromatography.
abstract: A simultaneous quantitative HPLC assay was developed for tiaramide hydrochloride (4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl]-1-piperazine ethanol hydrochloride) and its main metabolites, namely, 1 - [ (5-chloro-2-oxo-3 (2H) -benzothiazolyl) -acetyl]-piperazine (DETR) and 4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl] -piperazine acetic acid (TRAA). The assay was employed to determine plasma levels of tiaramide and its main metabolite, TRAA, after intravenous administration of tiaramide hydrochloride to rabbits.
authors.affiliation: Department of Pharmacy, Kyoto College of Pharmacy, Misasagi, Yamashina-ku, Kyoto, 607, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Naito
authors.forename: A
authors.initials: A
authors.lastname: Tanase
authors.forename: H
authors.initials: H
authors.lastname: Yoshihara
authors.forename: H
authors.initials: H
authors.lastname: Tominaga