title: Comparison of the MDRD study and CKD-EPI equations for the estimation of the glomerular filtration rate in the Korean general population: the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1), 2010.
abstract: BACKGROUND
  We compared the accuracy of the Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in Korean patients and evaluated the difference in CKD prevalence determined using the two equations in the Korean general population.
  
  
  METHODS
  The accuracy of the two equations was evaluated in 607 patients who underwent a chromium-51-ethylenediaminetetraacetic acid GFR measurement. Additionally, we compared the difference in CKD prevalence determined by the two equations among 5,822 participants in the fifth Korea National Health and Nutrition Examination Survey, 2010.
  
  
  RESULTS
  Among the 607 subjects, the median bias of the CKD-EPI equation was significantly lower than that of the MDRD study equation (0.9 vs. 2.2, p=0.020). The accuracy of the two equations was not significantly different in patients with mGFR <60 mL/min/1.73m(2); however, the accuracy of the CKD-EPI equation was significantly higher than that of the MDRD study equation in patients with GFR ≥60 mL/min/1.73m(2). The prevalences of the CKD stages 1, 2 and 3 in the Korean general population were 47.56, 49.23, and 3.07%, respectively, for the MDRD study equation; and were 68.48, 28.89, and 2.49%, respectively, for the CKD-EPI equation.
  
  
  CONCLUSIONS
  These data suggest that the CKD-EPI equation might be more useful in clinical practice than the MDRD study equation in Koreans.
authors.affiliation: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
authors.forename: Tae-Dong
authors.initials: TD
authors.lastname: Jeong
authors.forename: Woochang
authors.initials: W
authors.lastname: Lee
authors.forename: Sail
authors.initials: S
authors.lastname: Chun
authors.forename: Sang Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Jin-Sook
authors.initials: JS
authors.lastname: Ryu
authors.forename: Won-Ki
authors.initials: WK
authors.lastname: Min
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys / Q000379:methods*; D011159:Population Surveillance / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000208:ethnology* / Q000503:physiopathology; D056910:Republic of Korea / Q000208:ethnology