title: Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.
abstract: The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress with cognitive deficits being well characterized consequences of chronic stress. Although there is good evidence that acute stress can enhance cognitive performance, the mechanism(s) for this are unclear. We find that hippocampal slices, either prepared from rats following 30 min restraint stress or directly exposed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term potentiation. We demonstrate that the mechanism involves an NMDA receptor and PKA-dependent insertion of Ca2+ -permeable AMPA receptors into synapses. These then trigger the additional NMDA receptor-independent form of LTP during high frequency stimulation.
authors.affiliation: 1 Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK.
authors.forename: Garry
authors.initials: G
authors.lastname: Whitehead
authors.forename: Jihoon
authors.initials: J
authors.lastname: Jo
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Hogg
authors.forename: Thomas
authors.initials: T
authors.lastname: Piers
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Gillian
authors.initials: G
authors.lastname: Seaton
authors.forename: Heon
authors.initials: H
authors.lastname: Seok
authors.forename: Gilles
authors.initials: G
authors.lastname: Bru-Mercier
authors.forename: Gi Hoon
authors.initials: GH
authors.lastname: Son
authors.forename: Philip
authors.initials: P
authors.lastname: Regan
authors.forename: Lars
authors.initials: L
authors.lastname: Hildebrandt
authors.forename: Eleanor
authors.initials: E
authors.lastname: Waite
authors.forename: Byeong-Chae
authors.initials: BC
authors.lastname: Kim
authors.forename: Talitha L
authors.initials: TL
authors.lastname: Kerrigan
authors.forename: Kyungjin
authors.initials: K
authors.lastname: Kim
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Whitcomb
authors.forename: Graham L
authors.initials: GL
authors.lastname: Collingridge
authors.forename: Stafford L
authors.initials: SL
authors.lastname: Lightman
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
mesh_terms: D000818:Animals; D019921:Biotinylation; D002118:Calcium / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006727:Hormone Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000378:metabolism*; D012149:Restraint, Physical / Q000502:physiology*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D002118:Calcium; D003907:Dexamethasone; D018691:Excitatory Amino Acid Antagonists; D005938:Glucocorticoids; D006727:Hormone Antagonists; D015735:Mifepristone; D018727:Muscarinic Antagonists; D018091:Receptors, AMPA; D014633:Valine; C056639:2-amino-5-phosphopentanoic acid
keywords: calcium; glucocorticoids; glutamate receptor; long-term potentiation; metaplasticity