title: Ultrasound-triggered regulation of blood glucose levels using injectable nano-network.
abstract: The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, NC, 27695, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Di
authors.forename: Jennifer
authors.initials: J
authors.lastname: Price
authors.forename: Xiao
authors.initials: X
authors.lastname: Gu
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Jiang
authors.forename: Yun
authors.initials: Y
authors.lastname: Jing
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D048271:Chitosan / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D004337:Drug Carriers / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D049329:Nanostructures / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014464:Ultrasonic Therapy
chemical_list: D000464:Alginates; D001786:Blood Glucose; D004337:Drug Carriers; D006603:Hexuronic Acids; D007004:Hypoglycemic Agents; D007328:Insulin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020723:Glucuronic Acid; D048271:Chitosan
keywords: diabetes; drug delivery; insulin delivery; nano-network; ultrasound