title: Aurora-A: a potential DNA repair modulator.
abstract: It is well-known that overexpression of Aurora-A promotes tumorigenesis, but the role of Aurora-A in the development of cancer has not been fully investigated. Recent studies indicate that Aurora-A may confer cancer cell chemo- and radioresistance through dysregulation of cell cycle progression and DNA damage response. Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression. Other studies indicate that Aurora-A suppresses BRCA1, BRCA2, RAD51, poly(ADP ribose) polymerase (PARP), and gamma-H2AX to dysregulate DNA damage response. Aurora-A may also interact with RAS and Myc to control DNA repair indirectly. In this review, we summarized the potential role of Aurora-A in DNA repair from the current literatures and concluded that Aurora-A may function as a DNA repair modulator to control cancer cell radio- and chemosensitivity, and that Aurora-A-associated DNA repair molecules may be considered for targeted cancer therapy.
authors.affiliation: Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, China, wangxyyan@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Huizhen
authors.initials: H
authors.lastname: Sun
authors.forename: Ziliang
authors.initials: Z
authors.lastname: Wang
authors.forename: Mingming
authors.initials: M
authors.lastname: Liu
authors.forename: Zihao
authors.initials: Z
authors.lastname: Qi
authors.forename: Jiao
authors.initials: J
authors.lastname: Meng
authors.forename: Jianmin
authors.initials: J
authors.lastname: Sun
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D064096:Aurora Kinase A / Q000502:physiology*; D002453:Cell Cycle; D042002:Chromatin Assembly and Disassembly; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000628:therapy
chemical_list: D064096:Aurora Kinase A