title: Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L.
abstract: The dihydrofuroacridone, rutacridone, is the main alkaloid in tissue cultures of Ruta graveolens L. strain R-19. The biosynthesis of this particular acridone alkaloid was investigated by using calluses and suspension cultures of strain R-19. Anthranilic acid is specifically incorporated into ring A of rutacridone. Some further evidence was provided that acetate via a polyketide is involved in acridone biosynthesis. Mevalonic acid gave a poor incorporation into rutacridone. Thus the origin of the isopropyldihydrofuran moiety of the investigated alkaloid is still obscure.
authors.affiliation: Institut für Biochemie der Pflanzen, Akademie der Wissenschaften der DDR, DDR-4010 Halle (Saale), Weinberg 3, GDR.
authors.forename: A
authors.initials: A
authors.lastname: Baumert
authors.forename: I N
authors.initials: IN
authors.lastname: Kuzovkina
authors.forename: G
authors.initials: G
authors.lastname: Krauss
authors.forename: M
authors.initials: M
authors.lastname: Hieke
authors.forename: D
authors.initials: D
authors.lastname: Gröger