title: Impact of treatment with statins on prostate-specific antigen and prostate volume in patients with benign prostatic hyperplasia.
abstract: OBJECTIVE
  We investigated the impact on prostate-specific antigen (PSA) and prostate volume (PV) of statin medication for 1 year in patients with benign prostatic hyperplasia (BPH).
  
  
  METHODS
  We retrospectively investigated 791 patients in whom BPH was diagnosed. For analysis, the patients were divided into four groups according to their medications: group A, α-blocker; group B, α-blocker+statin; group C, α-blocker+dutasteride; group D, α-blockers+statin+dutasteride. To investigate changes in serum PSA, PV, and total cholesterol, we analyzed the data at the time of initial treatment and after 1 year of medication.
  
  
  RESULTS
  After 1 year, group A showed a 1.3% increase in PSA and a 1.0% increase in PV. Group B showed a 4.3% decrease in PSA and a 1.8% decrease in PV. The difference in PV reduction between groups A and B was statistically significant (p<0.001). Group C showed a 49.1% reduction in PSA and a 22.9% reduction in PV. Group D showed a 51.6% reduction in PSA and a 24.5% reduction in PV. The difference in PV reduction between groups C and D was not statistically significant (p=0.762). By use of a multivariate logistic regression model, we found that the probability of PV reduction after 1 year was more than 14.8 times in statin users than in statin nonusers (95% confidence interval, 5.8% to 37.6%; p<0.001).
  
  
  CONCLUSIONS
  Statin administration reduced PSA and PV in BPH patients. This finding may imply the improvement of lower urinary tract symptoms and prevention of cardiovascular disease and chemoprevention of prostate cancer with statin treatment.
authors.affiliation: Department of Urology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Tae Ju
authors.initials: TJ
authors.lastname: Park
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Bae
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Young Sam
authors.initials: YS
authors.lastname: Cho
authors.forename: Kwan Joong
authors.initials: KJ
authors.lastname: Joo
authors.forename: Chil Hun
authors.initials: CH
authors.lastname: Kwon
authors.forename: Heung Jae
authors.initials: HJ
authors.lastname: Park
keywords: Chemoprevention; Dutasteride; Prostate; Prostate-specific antigen; Statins