title: High-performance liquid chromatographic analysis of tocainide in human plasma.
abstract: A method for the determination of tocainide, a new antiarrhythmic drug, by means of ion-pair High Performance Liquid Chromatography (HPLC), is described. The drug and its chemically related internal standard are extracted from the basified plasma sample with methylene chloride. The organic extract is evaporated to dryness, dissolved in the mobile phase and chromatographed on a µ-Bondapak C-18 reversed phase column under radial compression. The detection limit is 200 ng/ml. The main metabolites as well as some frequently used antiarrhythmic drugs do not interfere in the assay.
authors.affiliation: K. U. Leuven, Klinische Farmacie, Laboratorium Galenische en Klinische Farmacie, Gasthuisberg, Herestraat, 49, B-3000, Leuven, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Conings
authors.forename: N
authors.initials: N
authors.lastname: Verbeke