title: Investigations into implantation failure in oocyte-donation recipients.
abstract: In recent decades, the Western world has been experiencing a societal trend to prioritize the professional careers of women who postpone motherhood to about 40 years of age, when, unfortunately, natural reproductive potential declines. This is the reason why these women increasingly find it necessary to resort to oocyte donation to have a child. Thanks to the young age of the donors, the efficacy of oocyte donation is the highest of all assisted reproduction treatments and pregnancy rates achieved with this technique exceed 50%. Moreover, the large registries from ESHRE and ASRM show live birth rates close to this figure. However, there are patients who experience repeated failures in several oocyte-donation cycles, and so far oocyte-donation repeated implantation failure has not been clearly defined. This study analysed the results obtained from 2531 oocyte-donation cycles carried out in 1990 patients and defines oocyte-donation repeated implantation failure as failure to implant with more than two embryo transfers and more than four high-grade embryos transferred. This study observed this condition in 140 oocyte recipients (7%). Also, oocyte cohort size, uterine factors and systemic thrombophilias as important aetiological factors were identified were to offer new therapeutic strategies to patients.
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain. Electronic address: perbar@dexeus.com.
authors.forename: Pedro N
authors.initials: PN
authors.lastname: Barri
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain.
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Coroleu
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Clua
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Tur
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Boada
authors.affiliation: Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Càtedra d' Investigació en Obstetricia i Ginecología, Universitat Autònoma de Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D017404:In Situ Hybridization, Fluorescence; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D013094:Spermatozoa / Q000166:cytology; D018709:Statistics, Nonparametric; D014599:Uterus / Q000473:pathology
keywords: IVF; implantation failure; infertility; oocyte donation