title: Risk factor analysis of calcification in aortic and mitral valves in maintenance peritoneal dialysis patients.
abstract: OBJECTIVE
  This study aimed to investigate potential risk factors for calcification in aortic and mitral valves in maintenance peritoneal dialysis (MPD) patients.
  
  
  METHODS
  We enrolled MPD patients who had undergone over 18 months of dialysis in our dialysis center, examined their cardiac valve calcification status by echocardiography, and recorded their biochemical data and dialysis-related indicators. These results were compared by logistic regression analyses to identify the risk factors associated with calcification in aortic and mitral valves.
  
  
  RESULTS
  Among the 117 enrolled MPD patients, 41 exhibited calcification in aortic or mitral valves, including 38 with aortic valve calcification (AVC) and 17 with mitral valve calcification (MVC); 14 of them had calcification in both aortic and mitral valves. Multivariate logistic regression analysis revealed that age (OR=1.965, p=0.01), diabetes history (OR=4.693, p=0.029), calcium-phosphorus product (OR=2.373, p=0.001) and prealbumin (OR=0.908, p=0.012) were independently related to AVC, whereas age (OR=3.179, p=0.023), calcium-phosphorus product (OR=6.512, p=0.001), prealbumin (OR=0.885, p=0.033), high-density lipoprotein (OR=19.540, p=0.011) and diabetes history (OR=6.948, p=0.038) were independently related to MVC.
  
  
  CONCLUSIONS
  The incidence of cardiac valve calcification in MPD patients is high, and the incidence of AVC is higher than MVC. Age, diabetes history, calcium-phosphorus product and hypo-prealbuminemia are independent risk factors for AVC, whereas age, calcium-phosphorus product and hypo-prealbuminemia are independent risk factors for MVC.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Wang
authors.forename: Linsen
authors.initials: L
authors.lastname: Jiang
authors.forename: Sheng
authors.initials: S
authors.lastname: Feng
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Shi
authors.forename: Huaying
authors.initials: H
authors.lastname: Shen
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Shi
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Yin
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000453:epidemiology*; D002114:Calcinosis / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000175:diagnosis* / Q000453:epidemiology*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012307:Risk Factors