title: Physiological and molecular biochemical mechanisms of bile formation.
abstract: This review considers the physiological and molecular biochemical mechanisms of bile formation. The composition of bile and structure of a bile canaliculus, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micellar structures, and enterohepatic circulation of bile acids are described. In general, the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract.
authors.affiliation: Vasiliy Ivanovich Reshetnyak, V.A. Negovsky Scientific Research Institute of General Reanimatology, Russian Academy of Medical Sciences, 107031 Moscow, Russia.
authors.forename: Vasiliy Ivanovich
authors.initials: VI
authors.lastname: Reshetnyak
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D001654:Bile Pigments / Q000378:metabolism; D001659:Biliary Tract / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D002483:Cellulose, Oxidized; D004764:Enterohepatic Circulation; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008823:Micelles; D010743:Phospholipids / Q000378:metabolism
chemical_list: D001654:Bile Pigments; D002352:Carrier Proteins; D002483:Cellulose, Oxidized; D008562:Membrane Glycoproteins; D008823:Micelles; D010743:Phospholipids; C037643:bile acid binding proteins
keywords: Bile acids; Bile micelle structures; Bile phospholipids; Bile salt transporters