title: Cell wall proteins of Sporothrix schenckii as immunoprotective agents.
abstract: Sporothrix schenckii is the etiological agent of sporotrichosis, an endemic subcutaneous mycosis in Latin America. Cell wall (CW) proteins located on the cell surface are inducers of cellular and humoral immune responses, potential candidates for diagnosis purposes and to generate vaccines to prevent fungal infections. This mini-review emphasizes the potential use of S. schenckii CW proteins as protective and therapeutic immune response inducers against sporotrichosis. A number of pathogenic fungi display CW components that have been characterized as inducers of protective cellular and humoral immune responses against the whole pathogen from which they were originally purified. The isolation and characterization of immunodominant protein components of the CW of S. schenckii have become relevant because of their potential in the development of protective and therapeutic immune responses against sporotrichosis. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).
authors.affiliation: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, México.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Alba-Fierro
authors.affiliation: Facultad de Medicina, Universidad Nacional Autónoma de México DF, México.
authors.forename: Armando
authors.initials: A
authors.lastname: Pérez-Torres
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, México.
authors.forename: Everardo
authors.initials: E
authors.lastname: López-Romero
authors.affiliation: Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, México.
authors.forename: Mayra
authors.initials: M
authors.lastname: Cuéllar-Cruz
authors.affiliation: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, México. Electronic address: erb750@hotmail.com.
authors.forename: Estela
authors.initials: E
authors.lastname: Ruiz-Baca
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology*; D005656:Fungal Proteins / Q000737:chemistry / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007155:Immunologic Factors / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D013175:Sporothrix / Q000737:chemistry / Q000276:immunology* / Q000472:pathogenicity; D013174:Sporotrichosis / Q000188:drug therapy* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014774:Virulence / Q000276:immunology
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D005656:Fungal Proteins; D006023:Glycoproteins; D007155:Immunologic Factors
keywords: Antígenos de la pared celular; Cell wall antigens; Cellular and humoral responses; Esporotricosis; Immunoprotection; Inmunoprotección; Respuesta inmunitaria celular y humoral; Sporothrix schenckii; Sporotrichosis