title: A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells.
abstract: A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H2O2 on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H2O2- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi "G. D'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. cacciatore@unich.it.
authors.forename: Ivana
authors.initials: I
authors.lastname: Cacciatore
authors.forename: Erika
authors.initials: E
authors.lastname: Fornasari
authors.forename: Leonardo
authors.initials: L
authors.lastname: Baldassarre
authors.forename: Catia
authors.initials: C
authors.lastname: Cornacchia
authors.forename: Stefania
authors.initials: S
authors.lastname: Fulle
authors.forename: Ester Sara
authors.initials: ES
authors.lastname: Di Filippo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pietrangelo
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinnen