title: f-MRI in Epilepsy with Spike and Wave Activity Evoked by Eye Closure: Different Bold Activation in a Patient with Idiopathic Partial Epilepsy with Occipital Spikes and a Control Group.
abstract: We performed functional magnetic resonance imaging (fMRI) in a 30-year-old man with idiopathic partial epilepsy with occipital spikes whose scalp EEG activity was characterized by persistent epileptiform discharges on eye closure, ceasing upon eye opening. We compared BOLD activation in the patient and in a control group of three normal volunteers. f-MRI showed that occipital cortex and frontal areas were activated in relation to eye movement in normal subjects during eye opening but not during eye closing. While persistent interictal spike and wave activity was present over the posterior and anterior scalp in the patient upon eye closing, f-MRI showed bilateral activation of the parietal and temporal regions. This fMRI study documents the activation of posterior and temporal areas related to continuous intercritical spikes evoked by eye closure, which are diffuse over the scalp. This activation was absent in the control group during eye closure.
authors.affiliation: Department of Neurological and Visual Sciences, Section of Rehabilitative Neurology, University of Verona; Verona, Italy - mirkoavesani@libero.it.
authors.forename: M
authors.initials: M
authors.lastname: Avesani
authors.forename: E
authors.initials: E
authors.lastname: Formaggio
authors.forename: S
authors.initials: S
authors.lastname: Storti
authors.forename: F
authors.initials: F
authors.lastname: Alessandrini
authors.forename: L G
authors.initials: LG
authors.lastname: Bongiovanni
authors.forename: C
authors.initials: C
authors.lastname: Cordioli
authors.forename: A
authors.initials: A
authors.lastname: Beltramello
authors.forename: A
authors.initials: A
authors.lastname: Fiaschi
authors.forename: P
authors.initials: P
authors.lastname: Manganotti