title: Neutralization positive but apparent false-positive hepatitis B surface antigen in a blood donor following influenza vaccination.
abstract: We report a case of transient, confirmed positive hepatitis B surface antigen (HBsAg) in a 25 year old long term Canadian Blood Services (CBS) donor, who reported receiving 2011-2012 seasonal trivalent (A/H1N1, A/H3N2, Influenza B) inactivated influenza vaccine two days before donation. To our knowledge, this report is the first published case implicating influenza vaccine as a possible factor in false-positive HBsAg test results. Seasonal incidence of repeat-reactive HBsAg among CBS donors suggests a potential contributory role of influenza vaccine or community acquired infection. We speculate that influenza vaccine may rarely be associated with sporadic, transient, false-positive HBsAg results.
authors.affiliation: Canadian Blood Services, BC & Yukon Centre, Vancouver, British Columbia, Canada. Electronic address: mark.bigham@blood.ca.
authors.forename: Mark
authors.initials: M
authors.lastname: Bigham
authors.affiliation: Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Arjuna
authors.initials: A
authors.lastname: Ponnampalam
mesh_terms: D000328:Adult; D001782:Blood Donors; D002170:Canada; D005189:False Positive Reactions; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects*; D007251:Influenza, Human / Q000517:prevention & control; D009500:Neutralization Tests; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000009:adverse effects
chemical_list: D006514:Hepatitis B Surface Antigens; D007252:Influenza Vaccines
keywords: False-positive; HBsAg; Influenza; Vaccine