title: Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG).
abstract: Two experiments examined probiotic pretreatment (Lactobacillus rhamnosus GG) on obsessive-compulsive disorder (OCD)-like behavior induction by RU 24969 in BALB/cJ house mice. In the first experiment, two groups were defined by their daily pretreatment by oral gavage of either (a) L. rhamnosus (1×10⁹ CFU/day) or (b) the saline vehicle. Both a 2- and 4-week probiotic pretreatment attenuated OCD-like behavior induction (increased perseverative open-field locomotion, stereotypic turning, and marble burying) relative to saline pretreatment. Experiment 2 re-examined the 2-week probiotic pretreatment while also comparing it to a 4-week fluoxetine pretreatment. Again, groups were defined by daily pretreatment of either (a) L. rhamnosus for 2 weeks, (b) the saline vehicle for 2 weeks, or (c) fluoxetine (10 mg/kg) for 4 weeks. Pretreatment by either L. rhamnosus or fluoxetine blocked the induction of OCD-like behavior compared with saline pretreatment. Thus the 2-week probiotic pretreatment was again effective. Although side effects of fluoxetine or L. rhamnosus on androgen-dependent behaviors could not be demonstrated, L. rhamnosus treatment appeared comparable to fluoxetine treatment in attenuating mouse OCD-like behaviors.
authors.affiliation: Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA.
authors.forename: Pranish A
authors.initials: PA
authors.lastname: Kantak
authors.forename: Dylan N
authors.initials: DN
authors.lastname: Bobrow
authors.forename: John G
authors.initials: JG
authors.lastname: Nyby
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D005473:Fluoxetine / Q000627:therapeutic use; D005612:Freeze Drying; D007211:Indoles / Q000633:toxicity; D007778:Lactobacillus / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced / Q000188:drug therapy*; D019936:Probiotics / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000633:toxicity; D012919:Social Behavior; D013997:Time Factors; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D018687:Antidepressive Agents, Second-Generation; D007211:Indoles; D017366:Serotonin Receptor Agonists; D005473:Fluoxetine; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole