title: Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects.
abstract: BACKGROUND
  We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects.
  
  
  METHODS
  We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-₁HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption.
  
  
  RESULTS
  In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-₁HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities.
  
  
  CONCLUSIONS
  These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
authors.affiliation: Lipids Laboratory (LIM-10), Endocrinology and Metabolism Division of Hospital das Clinicas, Faculty of Medical Sciences, University of Sao Paulo, Av, Dr, Arnaldo, 455 - room 3305, Sao Paulo CEP 01246-00, Brazil. equintao@terra.com.br.
authors.forename: Camila C
authors.initials: CC
authors.lastname: Leança
authors.forename: Valéria S
authors.initials: VS
authors.lastname: Nunes
authors.forename: Natália B
authors.initials: NB
authors.lastname: Panzoldo
authors.forename: Vanessa S
authors.initials: VS
authors.lastname: Zago
authors.forename: Eliane S
authors.initials: ES
authors.lastname: Parra
authors.forename: Patrícia M
authors.initials: PM
authors.lastname: Cazita
authors.forename: Matti
authors.initials: M
authors.lastname: Jauhiainen
authors.forename: Marisa
authors.initials: M
authors.lastname: Passarelli
authors.forename: Edna R
authors.initials: ER
authors.lastname: Nakandakare
authors.forename: Eliana C
authors.initials: EC
authors.lastname: de Faria
authors.forename: Eder C R
authors.initials: EC
authors.lastname: Quintão
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000172:deficiency; D008076:Cholesterol, HDL / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D056865:Ideal Body Weight; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007408:Intestinal Absorption; D008049:Lipase / Q000097:blood; D050356:Lipid Metabolism; D008052:Lipid Metabolism, Inborn Errors / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D049294:Phospholipid Transfer Proteins / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D007328:Insulin; C504173:LIPC protein, human; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase; C548261:LPL protein, human; D008071:Lipoprotein Lipase