title: Effect of dextran on the release of gonadotropin-releasing hormone (GnRH) injected into rats: plasma GnRH and gonadotropin response.
abstract: Prolonged release of the peptide gonadotropin-releasing hormone (GnRH) from its aqueous solution was achieved by addition of the polymer dextran (Mw ∼ 500,000). This effect observed in an in vitro system was caused by a decrease of the diffusion coefficient of the peptide. When GnRH was intramuscularly injected into male rats, the addition of dextran to the injected peptide solution led to a prolongation of the GnRH plasma level at the expense of its peak value. This change can be explained by a decrease of the absorption rate of GnRH into blood, which parallels the in vitro observation. As a result, the gonadotropin response to GnRH was stronly increased.
authors.affiliation: Institute of Drug Research, Academy of Sciences of the GDR, Alfred-Kowalke-Strasse 4, DDR-1136, Berlin, GDR.
authors.forename: N
authors.initials: N
authors.lastname: Heinrich
authors.forename: D
authors.initials: D
authors.lastname: Lorenz
authors.forename: H
authors.initials: H
authors.lastname: Berger
authors.forename: K
authors.initials: K
authors.lastname: Fechner
authors.forename: H E
authors.initials: HE
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
authors.forename: B
authors.initials: B
authors.lastname: Mehlis