title: A subchronic (180-day) oral toxicity study of ethyl tertiary-butyl ether, a bioethanol, in rats.
abstract: A subchronic (180-day) toxicity study was conducted to evaluate the effects of ethyl tertiary-butyl ether (ETBE), a biomass fuel, in male and female rats. ETBE was administered at dose levels of 0, 5, 25, 100 and 400 mg/kg/body weight (b.w.)/day by gavage. No treatment-related adverse effects were observed at 5, 25 or 100 mg/kg. Centrilobular hypertrophy of hepatocytes was observed in males and females and their relative liver weights were increased, suggesting enhanced metabolic activity. From these results, we concluded that the no observed adverse effect level of ETBE was 100 mg/kg b.w./day under the conditions tested.
authors.affiliation: CERI Hita, Chemicals Evaluation and Research Institute , Hita , Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyata
authors.forename: Takayuki
authors.initials: T
authors.lastname: Koga
authors.forename: Sunao
authors.initials: S
authors.lastname: Aso
authors.forename: Satsuki
authors.initials: S
authors.lastname: Hoshuyama
authors.forename: Syozo
authors.initials: S
authors.lastname: Ajimi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D018533:Biomass; D004305:Dose-Response Relationship, Drug; D005019:Ethyl Ethers / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic
chemical_list: D005019:Ethyl Ethers; C098546:ethyl tert-butyl ether
keywords: Ethyl tertiary butyl ether (ETBE); oral; rat; subchronic toxicity