title: A θ-γ oscillation code for neuronal coordination during motor behavior.
abstract: Sequential motor behavior requires a progression of discrete preparation and execution states. However, the organization of state-dependent activity in neuronal ensembles of motor cortex is poorly understood. Here, we recorded neuronal spiking and local field potential activity from rat motor cortex during reward-motivated movement and observed robust behavioral state-dependent coordination between neuronal spiking, γ oscillations, and θ oscillations. Slow and fast γ oscillations appeared during distinct movement states and entrained neuronal firing. γ oscillations, in turn, were coupled to θ oscillations, and neurons encoding different behavioral states fired at distinct phases of θ in a highly layer-dependent manner. These findings indicate that θ and nested dual band γ oscillations serve as the temporal structure for the selection of a conserved set of functional channels in motor cortical layer activity during animal movement. Furthermore, these results also suggest that cross-frequency couplings between oscillatory neuronal ensemble activities are part of the general coding mechanism in cortex.
authors.affiliation: Brain and Neural Systems Team, RIKEN Computational Science Research Program, Saitama 351-0198, Japan, Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, Saitama 351-0198, Japan, Brain Science Institute, Tamagawa University, Tokyo 194-8610, Japan, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Igarashi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Isomura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Arai
authors.forename: Rie
authors.initials: R
authors.lastname: Harukuni
authors.forename: Tomoki
authors.initials: T
authors.lastname: Fukai
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D058256:Brain Waves / Q000502:physiology*; D008297:Male; D009044:Motor Cortex / Q000166:cytology* / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010507:Periodicity; D025341:Principal Component Analysis; D051381:Rats; D020318:Rats, Long-Evans; D013997:Time Factors