title: Aspirin challenge in patients with chronic rhinosinusitis with polyps correlates with local and systemic inflammatory markers.
abstract: BACKGROUND
  Acetylsalicylic acid (ASA; aspirin) is a well-known inducer of pseudoallergic response in patients with chronic rhinosinusitis with polyps (CRSwPs). The mechanism that leads to this response remains unclear. This study was designed to measure and compare the local and systemic inflammatory response to aspirin challenge in patients with CRSwPs who develop either a nasobronchial response (NBR) or a nasal response (NR), and compare it with nonresponders (non-Rs).
  
  
  METHODS
  The three groups underwent nasal wash before ASA challenge, and inflammatory mediators were measured in the nasal wash as well as in serum.
  
  
  RESULTS
  A total of 25 CRSwP patients were enrolled. The NBR patients (n = 13) had a significantly longer mean disease duration and a higher mean serum leukotriene E4 (LTE4) level than the NR (n = 6) and non-R (n = 6) patients (39.2 ± 9.7 months, 21 ± 8.8 months, and 22.8 ± 11.2 months, respectively, and 4221 ± 1205 pg/mL, 1430 ± 605 pg/mL, and 857 ± 461 pg/mL, respectively). The NBR and NR patients had a larger mean number of nasal eosinophils than the non-R group (52.8 ± 28.8 cells/μL, 47 ± 21.3 cells/μL, and 19.3 ± 13.4 cells/μL, respectively). The tryptase, albumin, nasal LTE4, and prostaglandin E2 levels were not significantly different between the three groups in any examined combination.
  
  
  CONCLUSIONS
  The nasal eosinophil and serum LTE4 levels correlate with aspirin sensitivity.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Barzilai Medical Center, Ben Gurion University, Ashkelon, Israel.
authors.forename: Boaz
authors.initials: B
authors.lastname: Forer
authors.forename: Roee
authors.initials: R
authors.lastname: Landsberg
authors.forename: Shmuel
authors.initials: S
authors.lastname: Kivity
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000494:pharmacology*; D015415:Biomarkers; D002908:Chronic Disease; D015232:Dinoprostone / Q000032:analysis* / Q000502:physiology; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D017999:Leukotriene E4 / Q000032:analysis* / Q000502:physiology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry / Q000187:drug effects; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D012220:Rhinitis / Q000378:metabolism* / Q000473:pathology; D012852:Sinusitis / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D017999:Leukotriene E4; D015232:Dinoprostone; D001241:Aspirin