title: Brönsted acid-catalyzed one-pot synthesis of indoles from o-aminobenzyl alcohols and furans.
abstract: Brönsted acid-catalyzed one-pot synthesis of indoles from o-aminobenzyl alcohols and furans has been developed. This method operates via the in situ formation of aminobenzylfuran, followed by its recyclization into the indole core. The method proved to be efficient for substrates possessing different functional groups, including -OMe, -CO2Cy, and -Br. The resulting indoles can easily be transformed into diverse scaffolds, including 2,3- and 1,2-fused indoles, and indoles possessing an α,β-unsaturated ketone moiety at the C-2 position.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607-7061, United States.
authors.forename: Alexey
authors.initials: A
authors.lastname: Kuznetsov
authors.forename: Anton
authors.initials: A
authors.lastname: Makarov
authors.forename: Aleksandr E
authors.initials: AE
authors.lastname: Rubtsov
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Butin
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D000143:Acids / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000143:Acids; D001592:Benzyl Alcohols; D005663:Furans; D007211:Indoles