title: [Endothelial NO synthase and connexin 37 gene polymorphisms as a risk factor for myocardial infarction in subjects without a history of coronary artery disease].
abstract: OBJECTIVE
  To define a role of connexin37 (Cx37) C1019T and endothelial nitric oxide synthase (eNOS) G894T polymorphisms in the development of myocardial infarction (MI) in subjects without a history of coronary artery disease.
  
  
  RESULTS
  The investigation enrolled 183 male patients, of whom 56 (18.1%) developed MI in the presence of clinically and instrumentally verified coronary heart disease (CHD) (except MI) and 127 (81.9%) patients did without any previous clinical signs of CHD. The gene polymorphisms were identified using polymerase chain reaction and restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The spread of the G allele in the eNOS gene was 59.8% in the patients with MI in the presence of CHD and 75.6% in those with MI without a history of coronary artery disease (p<0.01). The GG genotype was found in 32.1 and 54.3%, respectively (p=0.01; the odds ratio (OR) was 2.5 with 95% confidence interval (CI) 1.3 to 4.9). The spread of the mutant T allele in the Cx37 gene was 29.5% in the patients with MI in the presence of CHD and 59.8% in those with MI without a history of coronary artery disease (p<0.01). The TT genotype was encountered in 7.1 and 42.5% of cases, respectively (p=0.01; OR 9.6 with 95% CI 3.3 to 28.4). There was no case of a combination of GG and TT genotypes among the patients with MI in the presence of CHD whereas this was found in 23.6% of the MI cases without a history of coronary artery disease (p<0.01).
  
  
  CONCLUSIONS
  Determination of Cx37 C1019T and eNOS G894T polymorphisms may be used to detect a genetic predisposition to the development of MI in patients with hemodynamically insignificant atherosclerosis and in apparently healthy individuals.
authors.forename: A V
authors.initials: AV
authors.lastname: Balatskiĭ
authors.forename: E Yu
authors.initials: EY
authors.lastname: Andreenko
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhodskaya
authors.forename: S A
authors.initials: SA
authors.lastname: Boĭtsov
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
mesh_terms: D000328:Adult; D015415:Biomarkers; D017630:Connexins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012306:Risk; D000097006:Gap Junction alpha-4 Protein
chemical_list: D015415:Biomarkers; D017630:Connexins; D052250:Nitric Oxide Synthase Type III; D000097006:Gap Junction alpha-4 Protein