title: Probability of live birth in women with extremely low anti-Müllerian hormone concentrations.
abstract: The aim of the present study was to investigate the clinical pregnancy and live birth rates in women with extremely low (≤ 0.4 ng/ml) anti-Müllerian hormone (AMH) concentrations. The study included 101 women (188 cycles) with extremely low AMH concentrations undergoing IVF cycles and compared the number of live births in women with low AMH. Moreover, the study compared the number of live births in women with or without endometriosis stage III/IV. Fourteen clinical pregnancies and 14 live births (including one pair of twins) were recorded; one woman miscarried. Significantly higher clinical pregnancy (P = 0.046) and live birth rates (P = 0.018) were found in women aged < 35 years compared with older women. AMH concentration did not differ significantly between women with or without endometriosis and there were six live births in women with endometriosis. This was not significantly different from the rate in healthy women. It is concluded that live births are possible in women with extremely low AMH concentrations. The presence of endometriosis stage III/IV did not affect live birth rates in women with extremely low AMH concentrations although an important limitation of the study is the small number of women included who were affected by that disease.
authors.affiliation: Department of Perinatology, Medical University, Gdańsk, Poland; INVICTA Fertility and Reproductive Center, Gdańsk, Poland; Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Varmia and Masuria, Olsztyn, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lukaszuk
authors.affiliation: INVICTA Fertility and Reproductive Center, Warszawa, Poland. Electronic address: michal.kunicki@invicta.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Kunicki
authors.affiliation: INVICTA Fertility and Reproductive Center, Gdańsk, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Liss
authors.affiliation: INVICTA Fertility and Reproductive Center, Warszawa, Poland.
authors.forename: Alicja
authors.initials: A
authors.lastname: Bednarowska
authors.affiliation: INVICTA Fertility and Reproductive Center, Warszawa, Poland; Department of Obstetrics and Gynaecology, Medical Center of Postgraduate Education, Warsaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Jakiel
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D054304:Anti-Mullerian Hormone / Q000172:deficiency*; D004715:Endometriosis / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D050498:Live Birth / Q000453:epidemiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D018709:Statistics, Nonparametric
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; DHEA; IVF; endometriosis; inhibin B; ovarian reserve