title: [Clinical significance and diagnostic value of Golgi-protein 73 in patients with early-stage primary hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the clinical significance and diagnostic value of GP73 in early-stage primary hepatocelluar carcinoma (PHC).
  
  
  METHODS
  GP73 levels in 50 healthy controls, 65 cases of liver cirrhosis and 40 early stage PHC were detected by ELISA. The areas under ROC, sensitivities and specificities were also compared. The relationship between GP73 and liver function parameters was analyzed.
  
  
  RESULTS
  The median of serum GP73 in early PHC was 291.3 µg/L, significantly higher than that in the cirrhosis group 211.8 µg/L and in the control group 58.3 µg/L (all P<0.01). The sensitivity of GP73 (72.5%) was significantly higher than that of AFP (50.0%), P<0.05. The specificity of GP73 (70.4%) was lower than that of AFP (95.7%), P<0.05. The sensitivity and specificity in combination for diagnosis were 77.5% and 79.1%, and the area under ROC curve in the combining form was 0.838 (95% CI:0.760-0.917). In the early PHC patients, the median of GP73 in the Child C group was 365.2 µg/L, significantly higher than that in the Child B group 310.6 µg/L and Child A group 266.4 µg/L, P = 0.002. In patients with liver cirrhosis, the median of GP73 in the Child B group was 307.3 µg/L, significantly higher than that in the Child A group 176.6 µg/L, P = 0.031. The level of serum GP73 was positively correlated with ALT, AST, negatively with ABL, A/G, and with no significant correlation with AFP, TBLB, DBLB, IBLB, and GGT.
  
  
  CONCLUSIONS
  GP73 has a superior sensitivity in detecting early-stage PHC in liver cirrhosis patients. The sensitivity can be further increased by combining with AFP. The changes of GP73 expression may be related with the decline of liver function.
authors.affiliation: Cancer Center of the First Affiliated Hospital at Xinjiang Medical University, Xinjiang,Urumqi 830054, China.
authors.forename: Yong-xing
authors.initials: YX
authors.lastname: Bao
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Hua-rong
authors.initials: HR
authors.lastname: Zhao
authors.forename: Rui
authors.initials: R
authors.lastname: Mao
authors.forename: Lei
authors.initials: L
authors.lastname: Xiao
authors.forename: Yue-feng
authors.initials: YF
authors.lastname: Zhang
authors.forename: Tulahong
authors.initials: T
authors.lastname: Aisiker
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D012372:ROC Curve; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C410824:GOLM1 protein, human; D008565:Membrane Proteins; D000509:alpha-Fetoproteins