title: Low elastic modulus titanium-nickel scaffolds for bone implants.
abstract: The superelastic nature of repeating the human bones is crucial to the ideal artificial biomedical implants to ensure smooth load transfer and foster the ingrowth of new bone tissues. Three dimensional interconnected porous TiNi scaffolds, which have the tailorable porous structures with micro-hole, were fabricated by slurry immersing with polymer sponge and sintering method. The crystallinity and phase composition of scaffolds were studied by X-ray diffraction. The pore morphology, size and distribution in the scaffolds were characterized by scanning electron microscopy. The porosity ranged from 65 to 72%, pore size was 250-500μm. Compressive strength and elastic modulus of the scaffolds were ~73MPa and ~3GPa respectively. The above pore structural and mechanical properties are similar to those of cancellous bone. In the initial cell culture test, osteoblasts adhered well to the scaffold surface during a short time, and then grew smoothly into the interconnected pore channels. These results indicate that the porous TiNi scaffolds fabricated by this method could be bone substitute materials.
authors.affiliation: State Key laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Hailin
authors.initials: H
authors.lastname: Yang
authors.forename: Huifeng
authors.initials: H
authors.lastname: Wang
authors.forename: Jianming
authors.initials: J
authors.lastname: Ruan
mesh_terms: D001842:Bone and Bones / Q000187:drug effects*; D048430:Cell Shape / Q000187:drug effects; D019245:Compressive Strength / Q000187:drug effects; D055119:Elastic Modulus / Q000187:drug effects*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: C040654:titanium nickelide; D009532:Nickel; D014025:Titanium
keywords: Biological evaluation in vitro; Cancellous bone substitute; Compressing properties; Pore structural properties; Porous TiNi alloy; Slurry immersing with polymer sponge and sintering method