title: The relationship of aeroallergen sensitization phenotypes to asthma control in primarily Hispanic asthmatic children.
abstract: OBJECTIVE
  The purpose of this study was to determine whether aeroallergen sensitization phenotypes could predict maintenance of well-controlled asthma.
  
  
  METHODS
  Asthmatic children age 2-18 years who enrolled in the CHOC Children's Breathmobile™ program from April 2002 to December 2011 were included in this retrospective analysis if they had been skin tested to a panel of indoor and outdoor aeroallergens and had returned for follow-up care within 6 months of their baseline visit. The study observation period encompassed all year one visits. Asthma severity and control were defined by NHLBI EPR-3 Guidelines criteria.
  
  
  RESULTS
  In the 1627 primarily Hispanic children evaluated, those with persistent asthma were more likely than those with intermittent disease to be sensitized to each aeroallergen tested and to have more total sensitizations. Children with intermittent, but not persistent, asthma at baseline who were sensitized to pollen2 (trees or weeds) were less likely to maintain well-controlled asthma at follow-up visits. Whereas, sensitization to dander (cat, dog or feather) showed a protective effect to maintenance of well-controlled asthma in patients with persistent, but not intermittent, baseline disease severity.
  
  
  CONCLUSIONS
  Our data suggest that both indoor and outdoor aeroallergens should be assessed regardless of baseline asthma severity, including those with intermittent asthma.
authors.affiliation: Morphew Consulting, LLC , Manhattan Beach, CA , USA .
authors.forename: T
authors.initials: T
authors.lastname: Morphew
authors.forename: Kenny Y C
authors.initials: KY
authors.lastname: Kwong
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: S P
authors.initials: SP
authors.lastname: Galant
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000485:Allergens / Q000276:immunology*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000208:ethnology* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000485:Allergens; D018927:Anti-Asthmatic Agents