title: Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan.
abstract: To evaluate the influence of vaccination dose and clinico-demographical factors on immune status against measles, rubella, mumps, and varicella viruses among university students, we conducted a case-control study by analyzing serum antibody titers according to past immunization and infection, and perinatal histories, using a multivariate regression model. A total of 1370 medical, paramedical, and pharmaceutical students were included in the analysis. Two or more doses of measles and rubella vaccination yielded notably greater odds ratios for immuno-positivity (9.1; 95% confidence interval (CI), 2.8-28.9 and 12.2; 95% CI, 0.71-210.3, respectively), compared with 1-dose vaccination, even though the superiority did not reach statistical significance for rubella. Students having younger/older siblings were more likely to be immuno-positive for mumps (2.5; 95% CI, 1.3-4.9 and 2.7; 95% CI, 1.4-5.5, respectively). On the other hand, post-term birth or macrosomia was associated with seronegative rubella virus antibodies. We concluded that a 2-dose vaccination strategy could successfully prevent measles and rubella outbreaks by increasing immunity.
authors.affiliation: Kyoto University Health Service.
authors.forename: Jiro
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Goto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraide
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage* / Q000276:immunology; D016017:Odds Ratio; D013334:Students / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D022542:Measles-Mumps-Rubella Vaccine