title: Surgical management of obesity in patients with morbid obesity and nonalcoholic fatty liver disease.
abstract: Most patients with severe complex obesity presenting for bariatric-metabolic surgery have nonalcoholic fatty liver disease (NAFLD). NAFLD is associated with central obesity, insulin resistance, type 2 diabetes, hypertension, and obesity-related dyslipidemia. Weight loss should be a primary therapy for NAFLD. However, evidence supporting intentional weight loss as a therapy for NAFLD is limited. Bariatric-metabolic surgery provides the most reliable method of achieving substantial sustained weight loss and the most commonly used procedures are associated with reduced steatosis and lobular inflammatory changes, but there are mixed reports regarding fibrosis. Surgery should complement treatment of obesity-related comorbidity, but not replace established therapy.
authors.affiliation: Clinical Obesity Research, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia; Primary Care Research Unit, Monash University, Melbourne, Australia. Electronic address: john.dixon@bakeridi.edu.au.
authors.forename: John B
authors.initials: JB
authors.lastname: Dixon
mesh_terms: D050110:Bariatric Surgery / Q000009:adverse effects / Q000379:methods; D005234:Fatty Liver / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008019:Life Style; D008099:Liver / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease; D009767:Obesity, Morbid / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D015431:Weight Loss
keywords: Diabetes; Gastric; Hypertension; Malabsorption; Metabolic; Mortality; Surgery; Weight loss