title: Is there an impact of 18F-FDG PET/CT on the surveillance and clinical management of recurrent ovarian cancer? Research based on a large sample in a single PET/CT center.
abstract: OBJECTIVE
  The aim of the study was to evaluate the use of F-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) in the follow-up and clinical management of ovarian cancer patients after therapy.
  
  
  METHODS
  A total of 152 ovarian cancer patients who had undergone therapy were evaluated. Clinical information, CA-125 levels, and traditional imaging findings were analyzed. According to the indication for PET/CT the patients were divided into five groups for assessing the role of (18)F-FDG PET/CT in the clinical management of ovarian cancer patients after therapy. A comparison was made between the PET/CT findings and the results of clinical follow-up.
  
  
  RESULTS
  Of the 152 patients, 137 had follow-up results and 15 were lost to follow-up. A total of 105 patients were found to have recurrent tumor and 32 were found to be disease-free after long-term follow-up. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 98.3, 91.2, 96.8, 97.5, and 93.9%, respectively. PET/CT was especially useful in patients when indications were to diagnose suspected recurrence, assess disease progression, and evaluate therapeutic response.
  
  
  CONCLUSIONS
  PET/CT has been proven to be extremely valuable in the evaluation of patients with recurrent ovarian cancer and is particularly helpful in guiding treatment planning.
authors.affiliation: aPET-CT Center, Department of Radiological Diagnosis and Therapy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China bDepartment of Radiology, USC Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Chi-shing
authors.initials: CS
authors.lastname: Zee
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Shi
authors.forename: Liang-rong
authors.initials: LR
authors.lastname: Wan
authors.forename: Lin-jun
authors.initials: LJ
authors.lastname: Tong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000378:metabolism; D003657:Decision Making; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018394:CA-125 Antigen; D019788:Fluorodeoxyglucose F18