title: Cytodifferentiation and alkaloid accumulation in cultured cells of Papaver bracteatum.
abstract: Cultured Papaver bracteatum cells accumulate large amounts of dopamine (0.1-4 mg/g fresh wt.) and much lower levels of the alkaloids, thebaine (0-6 μg/g fresh wt.) and sanguinarine (10-500 μg/g fresh wt.). Upon removal of hormone from their culture media, organogenesis and an elevation in morphinan alkaloid concentration were observed. Light and electron microscopic studies reveal that a correlation exists between the appearance of laticifer-like cells and thebaine in these cells.
authors.affiliation: E. A. Doisy Department of Biochemistry, Saint Louis University School of Medicine, 63104, St. Louis, MO, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Kutchan
authors.forename: S
authors.initials: S
authors.lastname: Ayabe
authors.forename: R J
authors.initials: RJ
authors.lastname: Krueger
authors.forename: E M
authors.initials: EM
authors.lastname: Coscia
authors.forename: C J
authors.initials: CJ
authors.lastname: Coscia