title: Studying the capability of different cancer hallmarks to initiate tumor growth using a cellular automaton simulation. Application in a cancer stem cell context.
abstract: We used a cellular automaton model for cancer growth simulation at cellular level, based on the presence of different cancer hallmarks acquired by the cells. The presence of the hallmarks in each of the cells determines cell mitotic and apoptotic behaviors. Depending on the presence of the different hallmarks and some associated parameters of the hallmarks, the system can evolve to different dynamics. We used the cellular automaton model to inspect the capability of different hallmarks to generate tumor growth in different conditions, using this study in a cancer stem cell context to analyze the capability of the hallmarks to tumor regrowth in different circumstances.
authors.affiliation: University of A Coruña, Department of Computer Science, Campus de Elviña s/n, 15071 A Coruña, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Monteagudo
authors.affiliation: University of A Coruña, Department of Computer Science, Campus de Elviña s/n, 15071 A Coruña, Spain. Electronic address: santos@udc.es.
authors.forename: José
authors.initials: J
authors.lastname: Santos
mesh_terms: D017209:Apoptosis / Q000502:physiology; D063646:Carcinogenesis; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D014411:Neoplastic Stem Cells / Q000502:physiology*
keywords: Cancer growth modeling; Cancer stem cells; Cellular automata; Cellular behavior