title: Retinal venous thrombosis in a young patient with coagulation factor XII deficiency.
abstract: METHODS
  A 35-year-old woman, with no relevant medical history, was referred for sudden vision loss in the left eye. Ophthalmological examination showed best corrected visual acuity of 1.0 in the right eye and 0.3 in left eye, with normal anterior pole and intraocular pressure. Fundus examination of the left eye revealed a venous thrombosis in the superior temporal branch, with dilated and tortuous retinal veins. The patient was referred to the hematology unit for thrombophilia study, and was diagnosed with a coagulation XII or Hageman factor deficiency.
  
  
  CONCLUSIONS
  The development of retinal vessel occlusions, in patients under 50 years of age, is frequently associated with thrombophilia or hypercoagulability disorders. Factor XII deficiency is a rare condition, and its presence could contribute to a higher risk of thromboembolic events.
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España. Electronic address: larabs70@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Borrego-Sanz
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Santos-Bueso
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Sáenz-Francés
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-de-la-Casa
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Feijoo
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Gegúndez-Fernández
authors.affiliation: Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Sánchez
mesh_terms: D005175:Factor XII Deficiency / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000209:etiology*
keywords: Coagulation factor xii; Factor xii coagulación; Thrombophilia; Trombofilia; Trombosis venosa; Venous thrombosis