title: Improved bioactivity of PAN-based carbon nanofibers decorated with bioglass nanoparticles.
abstract: Composite nanofibers composed of polyacrylonitrile (PAN)-based carbon nanofibers and bioactive glass (BG) nanoparticles have been prepared by electrospinning and in situ sintering. Morphology observation showed that the BG nanoparticles of size 20-50 nm were uniformly distributed on the surface of composite nanofibers with 350 nm average diameter after carbonization. Biological mineralization indicated the formation of apatite-like layer on the surface of composite nanofibers, in which the composition of carbonate hydroxyapatite was proved by FTIR and XRD analysis. Cell growth dynamics according to cellular morphology, CCK-8 assay, and alkaline phosphatase activity assay exhibited better cell adhesion, proliferation, and osteogenic induction of bone marrow-derived mesenchymal stem cells cultured on the composite nanofibers, which suggested the higher bioactivity of composite nanofibers compared to pure PAN-based carbon nanofibers.
authors.affiliation: a Department of Orthodontics, School and Hospital of Stomatology , Peking University , Beijing 100081 , P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Xuehui
authors.initials: X
authors.lastname: Zhang
authors.forename: Haiyang
authors.initials: H
authors.lastname: Liu
authors.forename: Xuliang
authors.initials: X
authors.lastname: Deng
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Jia
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010012:Osteogenesis; D051381:Rats; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; C010504:polyacrylonitrile; D002244:Carbon