title: Inspiratory muscle training for cystic fibrosis.
abstract: BACKGROUND
  Cystic fibrosis is the most common life-limiting genetic condition in Caucasians and the life-expectancy of those newly diagnosed is increasing. Inspiratory muscle training may be a way of improving the lung function and quality of life of people with cystic fibrosis. Hence there is a need to establish whether this intervention is beneficial.
  
  
  OBJECTIVE
  To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.
  
  
  METHODS
  We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials register comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of most recent search: 08 July 2013.
  
  
  METHODS
  Randomised or quasi-randomised clinical controlled trials comparing different inspiratory muscle training regimens with each other or a control in people with cystic fibrosis.
  
  
  METHODS
  Three review authors independently applied the inclusion and exclusion criteria to publications and assessed the quality of the included studies.
  
  
  RESULTS
  Fourteen studies were identified. Of these eight studies with 180 participants met the review inclusion criteria. There was wide variation in the quality of the included studies. Data were not published in sufficient detail or with sufficiently similar outcome measures in these studies to perform meta-analyses.
  
  
  CONCLUSIONS
  We have not found any evidence to suggest that this treatment is either beneficial or not. We would advise that practitioners evaluate on a case-by-case basis whether or not to employ this therapy. We recommend that future studies make more use of health-related quality of life and exercise tolerance measures; and that there is an agreement upon a single standard measure of classifying the clinical status of the participants.
authors.affiliation: School of Health & Social Care, Teesside University, Victoria Road, Middlesbrough, Cleveland, UK, TS1 3BA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Houston
authors.forename: Nicola
authors.initials: N
authors.lastname: Mills
authors.forename: Arturo
authors.initials: A
authors.lastname: Solis-Moya
mesh_terms: D001945:Breathing Exercises; D003550:Cystic Fibrosis / Q000628:therapy*; D006801:Humans; D001239:Inhalation / Q000502:physiology*; D016032:Randomized Controlled Trials as Topic; D012132:Respiratory Muscles / Q000502:physiology*