title: Comparison of whole blood collection and double-unit erythrocytapheresis in preoperative autologous blood donation.
abstract: BACKGROUND
  We compared preoperative autologous blood donation (PABD) using serial manual whole blood (WB) and PABD using a single session, double-unit erythrocytapheresis in terms of the hemodynamic recovery and clinical outcomes.
  
  
  METHODS
  This study included 56 donors in the WB PABD group and 117 donors in the double-unit erythrocytapheresis PABD group. All subjects were men with body weight >70 kg, Hb level >13.3g/dL, Hct >40%, and who were scheduled for oral and maxillofacial surgery. Three cycles of manual WB collection for PABD or a single session, double-unit erythrocytapheresis using the Alyx was performed.
  
  
  RESULTS
  There were no significant differences in donor demographic variables including age, height, weight, Hb, Hct, or red cell mass between the 2 groups. The double-unit erythrocytapheresis was completed earlier than the last manual WB PABD (at 15.3 ± 4.7 days and 6.5 ± 3.2 days before surgery, p<0.001). Hct values before surgery were higher in the double-unit erythrocytapheresis PABD group than in the manual WB PABD group (39.7 ± 3.2 vs. 38.6 ± 2.7, p=0.024). ΔHct and %ΔHct before the first PABD and before surgery were lower in the double-unit erythrocytapheresis PABD group than in the manual WB PABD group (-5.6 ± 2.8 vs. -6.8 ± 2.7, p=0.010 and -12.3 ± 5.9 vs. -14.8 ± 5.6, p=0.008, respectively). The incidence of additional allogeneic blood transfusions during or after surgery and the post-operative Hb and Hct values were similar in the 2 groups. The length of hospital stay after surgery was significantly longer in the manual WB PABD group than in the double-unit erythrocytapheresis group (6.1 ± 2.5 vs. 5.4 ± 1.9, p=0.043). Of the 33 donors in the double-unit erythrocytapheresis PABD group, 7 (21.2%) reported discomforts related to the procedure, and 6 graded the discomforts (hypocalcemia, perioral tingling sense, paresthesia, dizziness, stuffiness, pain on the intravenous site, and muscle tension) as mild.
  
  
  CONCLUSIONS
  The single session, double-unit erythrocytapheresis prolonged the time interval between PABD and surgery and led to better hemodynamic recovery than the serial manual WB PABD, and hypocalcemic symptoms were mild.
authors.affiliation: Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.
authors.forename: Miyoung
authors.initials: M
authors.lastname: Kim
authors.forename: Hyung Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Yang Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Ji Seon
authors.initials: JS
authors.lastname: Choi
authors.forename: Hoon Joo
authors.initials: HJ
authors.lastname: Yang
authors.forename: Soon Jung
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Myung Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Kyou-Sup
authors.initials: KS
authors.lastname: Han
mesh_terms: D001781:Blood Component Removal / Q000379:methods; D001782:Blood Donors; D001800:Blood Specimen Collection / Q000379:methods*; D001803:Blood Transfusion / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D016238:Cytapheresis; D004906:Erythrocyte Count; D006801:Humans; D008297:Male; D057234:Preoperative Period; D016896:Treatment Outcome
keywords: Apheresis; Erythrocytapheresis; Preoperative autologous blood donation