title: [Surveillance of bacterial distribution and drug resistance in inpatients with surgical infections: a single center study].
abstract: OBJECTIVE
  To investigate the bacterial distribution and drug resistance in patients with surgical infections, and provide the basis for the standardization treatment of the surgical infection.
  
  
  METHODS
  Retrospectively analyzed from January 2008 to December 2011 surgical infection in our samples bacteria identification and drug sensitivity test results.
  
  
  RESULTS
  A total of 3829 nonduplicate isolates from 3257 samples, Gram-negative bacteria accounted for 62.4% (the main microbes were P.aeruginosa, K. pneumonia and E.coli etc) and Gram-positive bacteria accounted for 37.6% (the main microbes were Enterococcus, Staphylococcus and coagulase negative Staphylococcus). Incidence of Staphylococcus aureus and Enterococcus faecalis were on an obvious increase. For the performance of the high level of sensitive to Imipenem, Amikacin, Piperacillin and Tazobactam by E. coli and K. pneumonia. The Pseudomonas aeruginosa and Acinetobacter baumannii to cephalosporins, Carbapenems and Fluoroqinolones were higher resistant with Multidrug resistance. No vancomycin and teicoplanin resistant Enterococcus faecium were found. The prevalence of ESBL E.coli was 45.6%-61.5% and ESBL K.pneumoniae isolates were fluctuated. The methicillin-resistant S.aureus (MRSA) isolates were relatively high (21.1%-55.8%), and methicillin-resistant Staphylococcus epidermidis was higher than the other Gram-positive cocci. Vancomycin for Staphylococcus performance was highly sensitive.
  
  
  CONCLUSIONS
  The main composition of surgical clinical infection pathogens are Gram-negative bacillus, and the emergency of resistance of bacteria to antibacterial drugs is a common phenomenon. The resistant rate shows ascendant trend; Drug resistance is significantly higher in Pseudomonas aeruginosa and Acinetobacter baumannii. Antimicrobial resistance is a serious and challenging issue.
authors.affiliation: Department of Gastrointestinal Surgery and Surgical Oncology Laboratory, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Ke-wei
authors.initials: KW
authors.lastname: Jiang
authors.forename: You
authors.initials: Y
authors.lastname: Lü
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.forename: Ying-jiang
authors.initials: YJ
authors.lastname: Ye
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Chun-jiang
authors.initials: CJ
authors.lastname: Zhao
authors.forename: Zhi-dong
authors.initials: ZD
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Liang
authors.initials: L
authors.lastname: Lü
authors.forename: Yi-chao
authors.initials: YC
authors.lastname: Yan
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents