title: [Serum proteomic analysis of cicatricial airway stenosis].
abstract: OBJECTIVE
  To establish serum protein fingerprint profile in patients with cicatricial airway stenosis and compared with healthy control.
  
  
  METHODS
  Serum samples of 17 cicatricial airway stenosis patients and 17 healthy persons were analyzed by SELDI-TOF-MS to select the differently expressed proteins through Biomarker Wizard software.
  
  
  RESULTS
  Compared with healthy control, 49 protein biomarkers were identified. Among them, 25 proteins were up-regulated, 24 proteins were down-regulated. These proteins were confirmed by searching database.
  
  
  CONCLUSIONS
  There are obvious differentially expressed proteins in patients with cicatricial airway stenosis and controls, which may related with the development of airway scar.
authors.affiliation: Department of Respiratory Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Li-huan
authors.initials: LH
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis* / Q000737:chemistry; D016022:Case-Control Studies; D002921:Cicatrix / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis; D020543:Proteome / Q000032:analysis / Q000737:chemistry; D040901:Proteomics / Q000379:methods*; D044967:Serum / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D014135:Tracheal Stenosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome