title: Outpatient management of oral anticoagulation in atrial fibrillation.
abstract: Atrial fibrillation is a commonly encountered problem in the outpatient setting. This article presents an overview of the outpatient management of oral anticoagulation for the prevention of stroke and systemic embolism in the setting of atrial fibrillation. Results of recent clinical trials demonstrating the efficacy and safety of 3 of the new target-specific oral anticoagulants are reviewed. Discussion includes determining patient candidates for the newer agents and consideration for choice of agent. Advantages and disadvantages to using these newer agents are presented, as are dosing adjustments for renal and hepatic impairment.
authors.affiliation: Woodlands North Houston Heart Center, 411 Lantern Bend Drive, Suite 100, Houston, TX 77090, USA. Electronic address: julie.manning@sbcglobal.net.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Manning
mesh_terms: D000553:Ambulatory Care; D000925:Anticoagulants / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D000069604:Dabigatran; D065427:Factor Xa Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D011728:Pyridones / Q000494:pharmacology / Q000627:therapeutic use; D000069552:Rivaroxaban; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D013876:Thiophenes / Q000494:pharmacology / Q000627:therapeutic use; D014859:Warfarin / Q000494:pharmacology / Q000627:therapeutic use; D015091:beta-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D009025:Morpholines; D011720:Pyrazoles; D011728:Pyridones; D013876:Thiophenes; D015091:beta-Alanine; C522181:apixaban; D014859:Warfarin; D000069552:Rivaroxaban; D000069604:Dabigatran
keywords: Atrial fibrillation; Oral anticoagulant; Outpatients; Stroke risk; Treatment