title: Effects of flattening filter-free and volumetric-modulated arc therapy delivery on treatment efficiency.
abstract: Flattening filter-free (FFF) beams are available on an increasing number of commercial linear accelerators. FFF beams have higher dose rates than flattened beams of equivalent energy which can lead to increased efficiency of treatment delivery, especially in conjunction with increased FFF beam energy and arc-based delivery configurations. The purpose of this study is to quantify and assess the implications of improved treatment efficiency for several FFF delivery options on common types of linac applicable radiotherapy. Eleven characteristic cases representative of a variety of clinical treatment sites and prescription doses were selected from our patient population. Treatment plans were generated for a Varian TrueBeam linear accelerator. For each case, a reference plan was created using DMLC IMRT with 6MV flat beams. From the same initial objectives, plans were generated using DMLC IMRT and volumetric-modulated arc therapy (VMAT) with 6 MV FFF and 10 MV FFF beams (max. dose rates of 1400 and 2400 MU/min, respectively). The plans were delivered to a phantom; beam-on time, total treatment delivery time, monitor units (MUs), and integral dose were recorded. For plans with low dose fractionations (1.8-2.0 & 3.85 Gy/fraction), mean beam-on time difference between reference plan and most efficient FFF plan was 0.56 min (41.09% decrease); mean treatment delivery time difference between the reference plan and most efficient FFF plan was 1.54 min (range: 0.31-3.56 min), a relative improvement of 46.1% (range: 29.2%-59.2%). For plans with high dose fractionations (16-20 Gy/fraction), mean beam-on time difference was 6.79 min (74.9% decrease); mean treatment delivery time difference was 8.99 min (range: 5.40-13.05 min), a relative improvement of 71.1% (range: 53.4%- 82.4%). 10 MV FFF VMAT beams generated the most efficient plan, except in the spine SBRT case. The distribution of monitor unit counts did not vary by plan type. In cases where respiratory motion management would be applicable, 10 MV FFF DMLC IMRT reduced beam-on time/field to less than 12 sec. FFF beams significantly reduced treatment delivery time. For radiosurgical doses, the efficiency improvement for FFF beams was clinically significant. For conventional fractionation, a large improvement in relative treatment delivery time was observed, but the absolute time savings were not likely to be of clinical value. In cases that benefit from respiratory motion management, beam-on/field was reduced to a time for which most patients can comfortably maintain deep inspiratory breath hold.
authors.affiliation: University of Alabama at Birmingham. ethomas@uab.edu.
authors.forename: Evan M
authors.initials: EM
authors.lastname: Thomas
authors.forename: Richard A
authors.initials: RA
authors.lastname: Popple
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Prendergast
authors.forename: Grant M
authors.initials: GM
authors.lastname: Clark
authors.forename: Michael C
authors.initials: MC
authors.lastname: Dobelbower
authors.forename: John B
authors.initials: JB
authors.lastname: Fiveash
mesh_terms: D019583:Dose Fractionation, Radiation; D005260:Female; D005374:Filtration; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy*; D010315:Particle Accelerators; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated