title: Temporal trends in incidence rates of herpes zoster among patients treated in primary care centers in Madrid (Spain), 2005-2012.
abstract: OBJECTIVE
  This study aimed to estimate total and age-specific incidence rates of HZ with data from electronic clinical records in primary care (ECRPC) and to analyze trends by sex and age.
  
  
  METHODS
  Descriptive cross-sectional study covering the incident HZ episodes registered in the ECRPC of the Madrid Regional Public Health System in 2005-2012. Annual crude and age-adjusted incidence rates were calculated. Differences by sex and age were assessed by poisson regression. The annual percentage of change (APC) of incidence rates and 'breakthrough points' of the time trends were determined with the Joinpoint Regression Program.
  
  
  RESULTS
  211,650 episodes of HZ were identified (60.6% women, 52.2% > 55 years). The incidence rate increased from 363.21 to 481.92 per 100,000 person-year in 2005-2012. Rates were higher among women and increased with age. The APC for the period was 3.59% in men and 3.67% in women (p < 0.05). Age-specific rates increased in patients over 14 years. The APC in the 25-44 age group was 7.4% since 2007. The incidence rate ratio (women/men) was highest in this group.
  
  
  CONCLUSIONS
  The incidence of HZ presents an upward trend in 2005-2012 in adults and the elderly. Monitoring the incidence and age-specific rates, will help to detect changes in trends.
authors.affiliation: Subdirectorate for Health Promotion and Prevention, Madrid Regional Health Authority, C/San Martín de Porres, 6, 28035 Madrid, Spain. Electronic address: maria.estebanv@salud.madrid.org.
authors.forename: M D
authors.initials: MD
authors.lastname: Esteban-Vasallo
authors.affiliation: Department of Preventive Medicine and Public Health and Medical Immunology and Microbiology, Rey Juan Carlos University, Avda. de Atenas, s/n, 28922 Alcorcón, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gil-Prieto
authors.affiliation: Subdirectorate for Health Promotion and Prevention, Madrid Regional Health Authority, C/San Martín de Porres, 6, 28035 Madrid, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Domínguez-Berjón
authors.affiliation: Subdirectorate for Health Promotion and Prevention, Madrid Regional Health Authority, C/San Martín de Porres, 6, 28035 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Astray-Mochales
authors.affiliation: Department of Preventive Medicine and Public Health and Medical Immunology and Microbiology, Rey Juan Carlos University, Avda. de Atenas, s/n, 28922 Alcorcón, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gil de Miguel
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D001330:Electronic Data Processing; D057286:Electronic Health Records; D005260:Female; D006562:Herpes Zoster / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
keywords: Herpes zoster; Incidence; Primary health care; Temporal trend