title: FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction.
abstract: The catalytic activity of FeCl3 for the synthesis of a variety of 4-substituted coumarins using high energy techniques has been investigated. The ultrasonic-assisted conditions provide a useful complement to the Pechmann reaction, affording the coumarin derivatives in excellent yields, under solvent-free conditions, in short reaction times using an inexpensive, mild and benign Lewis acid catalyst.
authors.affiliation: Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
authors.forename: Kyriakos C
authors.initials: KC
authors.lastname: Prousis
authors.affiliation: Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Avlonitis
authors.affiliation: Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Heropoulos
authors.affiliation: Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece. Electronic address: tcalog@eie.gr.
authors.forename: Theodora
authors.initials: T
authors.lastname: Calogeropoulou
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D002712:Chlorides / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D055772:Green Chemistry Technology; D014465:Ultrasonics
chemical_list: D002712:Chlorides; D003374:Coumarins; D005290:Ferric Compounds; C030123:coumarin; C024555:ferric chloride
keywords: FeCl(3) catalyst; Microwave; Pechmann reaction; Solvent-free; Ultrasound