title: Animal models of pancreatitis: can it be translated to human pain study?
abstract: Chronic pancreatitis affects many individuals around the world, and the study of the underlying mechanisms leading to better treatment possibilities are important tasks. Therefore, animal models are needed to illustrate the basic study of pancreatitis. Recently, animal models of acute and chronic pancreatitis have been thoroughly reviewed, but few reviews address the important aspect on the translation of animal studies to human studies. It is well known that pancreatitis is associated with epigastric pain, but the understanding regarding to mechanisms and appropriate treatment of this pain is still unclear. Using animal models to study pancreatitis associated visceral pain is difficult, however, these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral pain. In this review, the animal models of acute, chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.
authors.affiliation: Jing-Bo Zhao, Dong-Hua Liao, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, DK 9000 Aalborg, Denmark.
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Zhao
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: Liao
authors.forename: Thomas Dahl
authors.initials: TD
authors.lastname: Nissen
mesh_terms: D015746:Abdominal Pain / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D006801:Humans; D058748:Pain Perception; D017288:Pain Threshold; D010179:Pancreas / Q000294:innervation*; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011379:Prognosis; D013045:Species Specificity; D057170:Translational Research, Biomedical; D017833:Visceral Afferents / Q000503:physiopathology*
keywords: Animal model; Mechanism; Pancreatitis; Visceral pain