title: Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate.
abstract: Colorectal cancer (CRC) is a leading cause of cancer-related mortality. The early diagnosis and treatment of CRC is the key to improving the survival of patients who may benefit from adjuvant chemotherapy. In the present study, the protein expression of S100A3 was observed in a cohort of 20 patients with cancer, which indicated that S100A3 activation was involved in tumorigenesis. In addition, the anticancer activity of cantharidinate was investigated using immunohistochemistry and quantitative polymerase chain reaction (qPCR) analysis. The protein expression of S100A3 was observed to increase by 2.4-fold in human CRC cells compared with the expression level in normal control cells (P<0.01). Cantharidinate inhibited the protein and gene expression of S100A3 in UCT-116 human CRC cellsin vitro. These results suggested that S100A3 is important in human CRC. Cantharidinate has the potential to be considered as a novel adjuvant drug for controlling the expression of S100A3 in human CRC as it exhibits preventive effects.
authors.affiliation: Department of General Surgery, Jilin University Second Hospital, Changchun, Jilin 130041, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Sun
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Zhi
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Lu
authors.forename: Hai-Mei
authors.initials: HM
authors.lastname: Gao
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhou
authors.forename: Wei-Qun
authors.initials: WQ
authors.lastname: Yan
authors.forename: Hai-Cheng
authors.initials: HC
authors.lastname: Gao
keywords: S100A3; cantharidinate; colorectal cancer