title: Gastroduodenal perforation.
abstract: The cause and management of gastroduodenal perforation have changed as a result of increasing use of nonsteroidal antiinflammatories and improved pharmacologic treatment of acid hypersecretion as well as the recognition and treatment of Helicobacter pylori. As a result of the reduction in ulcer recurrence with medical therapy, the surgical approach to patients with gastroduodenal perforation has also changed over the last 3 decades, with ulcer-reducing surgery being performed infrequently.
authors.affiliation: Department of Surgery, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA. Electronic address: r.nirula@hsc.utah.edu.
authors.forename: Raminder
authors.initials: R
authors.lastname: Nirula
mesh_terms: D000208:Acute Disease; D001706:Biopsy; D004386:Duodenum / Q000473:pathology / Q000601:surgery; D005743:Gastrectomy; D006801:Humans; D010535:Laparoscopy; D010437:Peptic Ulcer / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010439:Peptic Ulcer Perforation / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010538:Peritonitis / Q000175:diagnosis / Q000601:surgery; D011379:Prognosis; D011706:Pyloric Antrum / Q000601:surgery; D011708:Pylorus / Q000601:surgery; D012307:Risk Factors; D055502:Secondary Prevention; D013270:Stomach / Q000473:pathology / Q000601:surgery; D013524:Surgical Flaps; D007507:Therapeutic Irrigation
keywords: Gastroduodenal; Perforation; Ulcer-reducing surgery