title: Synthesis of diversely substituted indoloquinolinones via Pd(II)/Cu(II)-mediated oxidative C-C bond formation and I(III)-mediated C-N bond formation.
abstract: A series of indoloquinolinones bearing different aromatic substitutents were readily synthesized starting from an aryl amine, a methyl 3-oxo-3-phenylpropanoate derivative, and methoxylamine through a series of reactions of coupling/enamination, oxidative annulation, a one-pot sequence of N-alkylation, saponification and methoxyamidation, and final intramolecular oxidative C-N bond formation. The underpinning of the strategy entails Pd(OAc)2/Cu(OAc)2-mediated oxidative C(sp(2))-C(sp(2)) bond formation and I(III)-mediated oxidative C(sp(2))-N bond formation.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Daisy
authors.initials: D
authors.lastname: Zhang-Negrerie
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D011804:Quinolines; D010165:Palladium; D003300:Copper; D007455:Iodine