title: The KCTD family of proteins: structure, function, disease relevance.
abstract: The family of potassium channel tetramerizationdomain (KCTD) proteins consists of 26 members with mostly unknown functions. The name of the protein family is due to the sequence similarity between the conserved N-terminal region of KCTD proteins and the tetramerization domain in some voltage-gated potassium channels. Dozens of publications suggest that KCTD proteins have roles in various biological processes and diseases. In this review, we summarize the character of Bric-a-brack,Tram-track, Broad complex(BTB) of KCTD proteins, their roles in the ubiquitination pathway, and the roles of KCTD mutants in diseases. Furthermore, we review potential downstream signaling pathways and discuss future studies that should be performed.
authors.affiliation: School of Basic Medical Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Zhepeng
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Jinchu University of Technology, No.33 xiangshan avenue, Jingmen 448000, People's Republic of China.
authors.forename: Yaqian
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: School of Basic Medical Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Sun