title: Repetitive transcranial magnetic stimulation applications normalized prefrontal dysfunctions and cognitive-related metabolic profiling in aged mice.
abstract: Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that has recently received increasing interests as a therapeutic procedure for neurodegenerative diseases. To identify the metabolism mechanism underlying the improving effects of rTMS, we observed that high frequency (25Hz) rTMS for 14 days could reverse the decline of the performance of the passive avoidance task in aged mice. We further investigated the metabolite profiles in the prefrontal cortex (PFC) in those mice and found that rTMS could also reverse the metabolic abnormalities of gamma-aminobutyric acid, N-acetyl aspartic, and cholesterol levels to the degree similar to the young mice. These data suggested that the rTMS could ameliorate the age-related cognitive impairment and improving the metabolic profiles in PFC, and potentially can be used to improve cognitive decline in the elderly.
authors.affiliation: Department of Neurology, the first hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Hualong
authors.initials: H
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Geng
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Jing
authors.initials: J
authors.lastname: Qiang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
authors.forename: Meiyu
authors.initials: M
authors.lastname: Sun
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000818:Animals; D001362:Avoidance Learning; D003071:Cognition; D004924:Escape Reaction; D005260:Female; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D051379:Mice; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation