title: Small Rho GTPases in the control of cell shape and mobility.
abstract: Rho GTPases are a class of evolutionarily conserved proteins comprising 20 members, which are predominantly known for their role in regulating the actin cytoskeleton. They are primarily regulated by binding of GTP/GDP, which is again controlled by regulators like GEFs, GAPs, and RhoGDIs. Rho GTPases are thus far well known for their role in the regulation of actin cytoskeleton and migration. Here we present an overview on the role of Rho GTPases in regulating cell shape and plasticity of cell migration. Finally, we discuss the emerging roles of ubiquitination and sumoylation in regulating Rho GTPases and cell migration.
authors.affiliation: Cell Death Signaling Group, Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany.
authors.forename: Arun
authors.initials: A
authors.lastname: Murali
authors.forename: Krishnaraj
authors.initials: K
authors.lastname: Rajalingam
mesh_terms: D002465:Cell Movement; D048430:Cell Shape; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D058207:Sumoylation; D054875:Ubiquitination; D020764:cdc42 GTP-Binding Protein / Q000737:chemistry / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
chemical_list: D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins