title: CT angiographic imaging characteristics of thoracic idiopathic aortitis.
abstract: BACKGROUND
  Idiopathic aortitis (IA) is characterized by giant cell or lymphoplasmacytic inflammation of aorta without a secondary cause.
  
  
  OBJECTIVE
  We undertook a retrospective case-control study to identify characteristic CT angiographic findings in these patients and to correlate them with known atherosclerotic risk factors.
  
  
  METHODS
  IA cases and controls with noninflammatory aneurysm (control group I) and patients with secondary aortitis (control group II) were identified with a pathology database. Preoperative CT angiographic images of thoracic aorta were reviewed. Diameter of thoracic aorta, wall thickness, and calcification were measured at various sites. Traditional atherosclerotic risk factors were identified from case records and included hypertension, hyperlipidemia, diabetes mellitus, and smoking.
  
  
  RESULTS
  Twenty-two idiopathic aortitis cases were compared with 18 patients in control group I and 16 patients in control group II. No differences were found in prevalence of hypertension and diabetes, but hyperlipidemia was more prevalent in the control group I than in cases (72% vs 36%; P = .03). Current smoking was more prevalent in cases (24%) than for patients in control group I (6%) and group II (19%) but not statistically significant (P = .18 and .69, respectively). Thoracic aortic diameters at various points were significantly larger in cases than for patients in control group I. Calcification was more frequent in cases than for patients in control group II. No differences in wall thickness were found. No meaningful correlation was observed between atherosclerotic risk factors and aortic diameter and calcification scores.
  
  
  CONCLUSIONS
  Patients with IA have significantly larger and more diffuse dilatation of the thoracic aorta than patients with noninflammatory aneurysms.
authors.affiliation: Division of Rheumatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Vaidehi R
authors.initials: VR
authors.lastname: Chowdhary
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Crowson
authors.forename: Anjali S
authors.initials: AS
authors.lastname: Bhagra
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Warrington
authors.forename: Terri J
authors.initials: TJ
authors.lastname: Vrtiska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000453:epidemiology; D001025:Aortitis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D001027:Aortography / Q000379:methods*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000453:epidemiology
keywords: Giant cell aortitis; Idiopathic aortitis; Isolated aortitis; Lymphoplasmacytic aortitis; Vasculitis