title: Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier.
abstract: The absorption of etoposide (VP-16-213) was investigated in a perfused intestinal loop. The absorbed amount of drug was determined by collecting the blood draining the loop via cannulation of the efferent jejunal vein. The absorption rate of VP-16-213 strongly depended on the composition of the perfusion medium. The addition of taurocholate to an aqueous etoposide solution enhanced the absorption rate. When N-acetylcysteine was added to an aqueous solution, the absorption rate dropped significantly.
authors.affiliation: Department of Pharmaceutics, State University of Utrecht, Catharijnesingel 60, 3511 GH, Utrecht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Schurgers
authors.forename: C J
authors.initials: CJ
authors.lastname: de Blaey
authors.forename: D J
authors.initials: DJ
authors.lastname: Crommelin