title: Deep brain stimulation for Tourette syndrome.
abstract: Gilles de la Tourette syndrome is a movement disorder characterized by repetitive stereotyped motor and phonic movements with varying degrees of psychiatric comorbidity. Deep brain stimulation (DBS) has emerged as a novel therapeutic intervention for patients with refractory Tourette syndrome. Since 1999, more than 100 patients have undergone DBS at various targets within the corticostriatothalamocortical network thought to be implicated in the underlying pathophysiology of Tourette syndrome. Future multicenter clinical trials and the use of a centralized online database to compare the results are necessary to determine the efficacy of DBS for Tourette syndrome.
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles 10945, Le Conte Avenue, Suite 2120, Los Angeles, CA 90095, USA. Electronic address: wonism@gmail.com.
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.forename: Nader
authors.initials: N
authors.lastname: Pouratian
mesh_terms: D001479:Basal Ganglia / Q000502:physiology; D046690:Deep Brain Stimulation / Q000009:adverse effects; D006801:Humans; D020646:Intralaminar Thalamic Nuclei / Q000502:physiology; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D020531:Subthalamic Nucleus / Q000502:physiology; D005879:Tourette Syndrome / Q000628:therapy*; D016896:Treatment Outcome
keywords: Deep brain stimulation; Neuromodulation; Tics; Tourette Syndrome