title: Hampered by historical paradigms--echinocandins and the treatment of Candida endocarditis.
abstract: Infective endocarditis due to Candida sp. has a high mortality rate. Traditionally, management involves early surgery and prolonged amphotericin ± flucytosine. We report a case of Candida parapsilosis bileaflet mitral valve endocarditis cured with anidulafungin and fluconazole, and review the role of echinocandins in the management of Candida endocarditis.
authors.affiliation: Monash Infectious Diseases, Monash Medical Centre, Clayton, Vic., Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Gardiner
authors.forename: M A
authors.initials: MA
authors.lastname: Slavin
authors.forename: T M
authors.initials: TM
authors.lastname: Korman
authors.forename: R L
authors.initials: RL
authors.lastname: Stuart
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification* / Q000502:physiology; D054714:Echinocandins / Q000627:therapeutic use; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D015725:Fluconazole; D000077612:Anidulafungin
keywords: Candida; anidulafungin; echinocandin; endocarditis