title: Nickel-mediated stereocontrolled synthesis of spiroketals via tandem cyclization-coupling of β-bromo ketals and aryl iodides.
abstract: A ketal-tether approach for the stereoselective synthesis of [5,5] and [5,6]-spiroketals based on reductive coupling catalyzed by the readily available Ni complex is demonstrated. Either an intermolecular or an intramolecular stereospecific cascade has been achieved as well.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China. pengyu@lzu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Peng
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005663:Furans; D007454:Iodides; D013141:Spiro Compounds; C520774:spiroketal; D009532:Nickel