title: Assessment of arterial stiffness among schizophrenia-spectrum disorders using aortic pulse wave velocity and arterial compliance: a pilot study.
abstract: Cardiovascular disease (CVD) is the leading cause of death in individuals with chronic schizophrenia. Arterial stiffness provides a non-invasive indication of cardiovascular disease risk. To date, arterial stiffness, which has been shown to have independent predictive value for CVD morbidity and mortality, has not been evaluated in this population. We aimed to examine aortic pulse wave velocity (aPWV) as well as large and small artery compliance (Comp1 and Comp2) in patients being treated for schizophrenia, compared to healthy volunteers. Ten patients and 10 age and gendermatched volunteers underwent a comprehensive evaluation of arterial stiffness including: aPWV, Comp1, Comp2, stroke volume, cardiac output, and systemic vascular resistance. Patient aPWV was significantly elevated compared to healthy volunteers (9.1 ± 4.11 vs. 5.7 ± 1.4, P=0.03). Increased age, blood pressure, heart rate, and cigarettes/day were associated with reduced arterial health in patients. This is the first time aPWV has been described in those treated for schizophrenia. Arterial stiffness is increased in this population. Measuring arterial stiffness is a non-invasive, sensitive and effective tool for evaluating CVD risk in this population.
authors.affiliation: Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, Canada; Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: Aaron A
authors.initials: AA
authors.lastname: Phillips
authors.affiliation: Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, Canada; Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: darren.warburton@ubc.ca.
authors.forename: Darren E R
authors.initials: DE
authors.lastname: Warburton
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of British Columbia, Canada.
authors.forename: Sean W
authors.initials: SW
authors.lastname: Flynn
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of British Columbia, Canada.
authors.forename: Diane
authors.initials: D
authors.lastname: Fredrikson
authors.affiliation: Department of Radiology, Faculty of Medicine, University of British Columbia, Canada.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lang
mesh_terms: D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D010865:Pilot Projects; D063177:Pulse Wave Analysis; D012559:Schizophrenia / Q000503:physiopathology*; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: Arteriosclerosis; Cardiovascular risk; Schizophrenia