title: Visible-light-mediated decarboxylation/oxidative amidation of α-keto acids with amines under mild reaction conditions using O(2).
abstract: Photochemistry has ushered in a new era in the development of chemistry, and photoredox catalysis has become a hot topic, especially over the last five years, with the combination of visible-light photoredox catalysis and radical reactions. A novel, simple, and efficient radical oxidative decarboxylative coupling with the assistant of the photocatalyst [Ru(phen)3 ]Cl2 is described. Various functional groups are well-tolerated in this reaction and thus provides a new approach to developing advanced methods for aerobic oxidative decarboxylation. The preliminary mechanistic studies revealed that: 1) an SET process between [Ru(phen)3 ](2+) * and aniline play an important role; 2) O2 activation might be the rate-determining step; and 3) the decarboxylation step is an irreversible and fast process.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan (P. R. China).
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.forename: Chu
authors.initials: C
authors.lastname: Qin
authors.forename: Ruopeng
authors.initials: R
authors.lastname: Bai
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Qi
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D003653:Decarboxylation / Q000528:radiation effects; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D007651:Keto Acids / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D012428:Ruthenium
chemical_list: D000577:Amides; D000588:Amines; D000814:Aniline Compounds; D006843:Hydrocarbons, Chlorinated; D007651:Keto Acids; D012428:Ruthenium; D010100:Oxygen; C023650:aniline
keywords: amides; computational chemistry; photochemistry; reaction mechanism; synthetic methods