title: Breast cancer brain metastases: a review of the literature and a current multidisciplinary management guideline.
abstract: Breast cancer represents the second most frequent etiology of brain metastasis (BM). It is estimated that 10-30 % of patients with breast cancer are diagnosed with BM. Breast cancer BM are increasing due to the aging population, detection of subclinical disease, and better control of systemic disease. BM is a major cause of morbidity and mortality affecting neurocognition, speech, coordination, behavior, and quality of life. The therapy of BM remains controversial regarding use and timing of surgical resection, application of whole-brain radiotherapy, stereotactic radiosurgery and systemic drugs in patients with particular tumor subtypes. Despite numerous trials, the range of interpretation of these has resulted in differing treatment perspectives. This paper is a review of the state of the art and a multidisciplinary guideline on strategies to improve the therapeutic index in this situation.
authors.affiliation: Breast Cancer Unit and Neurooncology Unit, Institut Català d'Oncologia (ICO), IDIBELL, Gran Via 199-203, L'Hospitalet, 08908, Barcelona, Spain, secretaria@geino.es.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gil-Gil
authors.forename: M
authors.initials: M
authors.lastname: Martinez-Garcia
authors.forename: A
authors.initials: A
authors.lastname: Sierra
authors.forename: G
authors.initials: G
authors.lastname: Conesa
authors.forename: S
authors.initials: S
authors.lastname: Del Barco
authors.forename: S
authors.initials: S
authors.lastname: González-Jimenez
authors.forename: S
authors.initials: S
authors.lastname: Villà
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D010348:Patient Care Team; D017410:Practice Guidelines as Topic