title: Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
abstract: Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
authors.affiliation: Departments of Immunology and Microbiology and Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065.
authors.forename: Poonam
authors.initials: P
authors.lastname: Rath
authors.forename: Chengdong
authors.initials: C
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Wang
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: Rafael
authors.initials: R
authors.lastname: Prados-Rosales
authors.forename: Olivier
authors.initials: O
authors.lastname: Elemento
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Carl F
authors.initials: CF
authors.lastname: Nathan
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D054884:Host-Pathogen Interactions; D056747:Immunomodulation / Q000235:genetics / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism*; D008264:Macrophages; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology*; D017510:Protein Folding; D051195:Toll-Like Receptor 2 / Q000819:agonists / Q000235:genetics; D022161:Transport Vesicles / Q000378:metabolism / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D051195:Toll-Like Receptor 2
keywords: TLR2; macrophages