title: Development of a rapid screening method to determine primary aromatic amines in kitchen utensils using direct analysis in real time mass spectrometry (DART-MS).
abstract: Primary aromatic amines (PAAs) are a group of substances with undesirable health effects, that are used in a variety of commercial products. Several recent studies, using a number of screening and confirmatory methods, have reported the migration of PAAs from some kitchen utensils into acetic acid 3% (w/v). Many of these methods require significant sample preparation, therefore the aim of this work was to determine if direct analysis in real time mass spectrometry (DART-MS) could be utilised as a rapid screening tool for the determination of PAAs in kitchen utensils. DART-MS results from direct analysis of the utensil have been compared with results of PAA migration by ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method. The UPLC-MS/MS method had excellent linearity, appropriate sensitivity (LOD ≤ 1.5 µg L(-1); LOQ ≤ 4.5 µg L(-1)), repeatability from 2.4 to 13.2% and acceptable recoveries. DART-MS results were in good agreement with UPLC-MS/MS data, with 100% of non-compliant (PAA positive) samples successfully identified by DART-MS.
authors.affiliation: a Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy , University of Santiago de Compostela , Santiago de Compostela E-15782 , Spain.
authors.forename: R
authors.initials: R
authors.lastname: Paseiro-Cerrato
authors.forename: G O
authors.initials: GO
authors.lastname: Noonan
authors.forename: T H
authors.initials: TH
authors.lastname: Begley
mesh_terms: D000588:Amines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000706:statistics & numerical data; D003199:Computer Systems; D003297:Cooking and Eating Utensils; D005506:Food Contamination / Q000032:analysis*; D064088:Hazard Analysis and Critical Control Points / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D017550:Spectroscopy, Fourier Transform Infrared; D053719:Tandem Mass Spectrometry / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D000588:Amines