title: What should be disclosed to research participants?
abstract: Debate surrounding the SUPPORT study highlights the absence of consensus regarding what information should be disclosed to potential research participants. Some commentators endorse the view that clinical research should be subject to high disclosure standards, even when it is testing standard-of-care interventions. Others argue that trials assessing standard-of-care interventions need to disclose only the information that is disclosed in the clinical care setting. To resolve this debate, it is important to identify the ethical concerns raised by clinical research and determine what consent process is needed to address them.
authors.affiliation: a Department of Bioethics , NIH Clinical Center.
authors.forename: David
authors.initials: D
authors.lastname: Wendler
mesh_terms: D016265:Conflict of Interest; D030881:Disclosure / Q000941:ethics*; D026689:Ethical Analysis; D018380:Hematopoietic Stem Cell Transplantation / Q000941:ethics; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D010817:Physician-Patient Relations / Q000941:ethics*; D016032:Randomized Controlled Trials as Topic / Q000941:ethics*; D012108:Research Personnel / Q000941:ethics* / Q000331:legislation & jurisprudence; D035842:Research Subjects; D035844:Researcher-Subject Relations / Q000941:ethics*; D012306:Risk; D059039:Standard of Care / Q000941:ethics*; D014481:United States