title: Small cell tumors of the thyroid gland: a review.
abstract: The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid tumors with EWSR1-FLI1 rearrangement together with neuroendocrine and/or carcinomatous differentiation raises not only differential diagnostic problems but also a very interesting therapeutic dilemma. This review explores the classification of small cell tumors of the thyroid taking into account the immunophenotype and molecular profile of such tumors.
authors.affiliation: 1IPATIMUP (Institute of Molecular Pathology and Immunology of the University of Porto), Porto, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Eloy
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Cameselle-Teijeiro
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Rousseau
authors.forename: Manuel
authors.initials: M
authors.lastname: Sobrinho-Simões
mesh_terms: D018288:Carcinoma, Small Cell; D006801:Humans; D013964:Thyroid Neoplasms
keywords: calcitonin; medullary carcinoma; neuroendocrine tumor; primary extraskeletal Ewing family tumors; small cell carcinoma; thyroid