title: Behavioral disorders in Parkinson's disease: the role of dopamine.
abstract: Dopaminergic neurons play a major role in controlling movement and behavior. In Parkinson's disease (PD), dopaminergic denervation is responsible for a number of motor and non-motor symptoms including tremor, rigidity and akinesia and as well apathy, impulsivity and other behavioral complications frequently reported in these patients. In this review, we will summarize the possible proposed dopaminergic mechanisms responsible for these complications in PD, focusing mainly on the role of this neurotransmitter in behavioral symptoms.
authors.affiliation: Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Parkinson's Disease and Movement Disorders Unit, Neurology Clinic, Hospital Clinic Universitari, University of Barcelona, Barcelona, Spain.
authors.forename: Francesca
authors.initials: F
authors.lastname: Antonelli
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Strafella
mesh_terms: D001526:Behavioral Symptoms / Q000209:etiology* / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications*
chemical_list: D004298:Dopamine
keywords: Behavioral disorder; Dopamine; Impulsivity; Neuroimaging