title: Predictive role of high sensitive C-reactive protein in early onset mortality after ischemic stroke.
abstract: BACKGROUND
  High sensitive C-reactive protein (hs-CRP) is a systemic inflammatory marker that is produced in a large amount by hepatocytes in response to interleukin-1 (IL-1), IL-6 and tumor necrosis factor after ischemic stroke.
  
  
  METHODS
  Measurement of hs-CRP in the first 24 hours of onset in 162 patients suffering from ischemic stroke was done. Relation of CRP with the risk of early mortality, National Institutes of Health Stroke Scale (NIHSS), stroke subtypes and other factors was determined.
  
  
  RESULTS
  Regarding to ROC curve analysis, appropriate cut-off point for predicting patients' short time mortality was equal to 2.15 mg/dl in this study. Significantly increased rate of mortality by 13.3 times was seen in patients with simultaneous CRP > 2.15 mg/dl and NIHSS > 10.
  
  
  CONCLUSIONS
  The Result of this study showed that there is a direct association between hs-CRP and mortality within the first week after stroke. Measuring hs-CRP within the first hours after stroke increases the predicting rate of early mortality risk with cut-off point of 2.15.
authors.affiliation: Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Mohebbi
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Ghabaee
authors.forename: Majid
authors.initials: M
authors.lastname: Ghaffarpour
authors.forename: Ali Pasha
authors.initials: AP
authors.lastname: Meisami
authors.forename: Reza Shah
authors.initials: RS
authors.lastname: Siah
authors.forename: Mohammad Reza Mousavi
authors.initials: MR
authors.lastname: Mirkala
authors.forename: Maryam Pour
authors.initials: MP
authors.lastname: Ashraf
authors.forename: Mahbubeh
authors.initials: M
authors.lastname: Yaghubi
keywords: Acute Ischemic Stroke; High Sensitive C-reactive Protein; Inflammatory Biomarkers; Mortality