title: Relative survival of patients with non-malignant central nervous system tumours: a descriptive study by the Austrian Brain Tumour Registry.
abstract: BACKGROUND
  Unlike malignant primary central nervous system (CNS) tumours outcome data on non-malignant CNS tumours are scarce. For patients diagnosed from 1996 to 2002 5-year relative survival of only 85.0% has been reported. We investigated this rate in a contemporary patient cohort to update information on survival.
  
  
  METHODS
  We followed a cohort of 3983 cases within the Austrian Brain Tumour Registry. All patients were newly diagnosed from 2005 to 2010 with a histologically confirmed non-malignant CNS tumour. Vital status, cause of death, and population life tables were obtained by 31 December 2011 to calculate relative survival.
  
  
  RESULTS
  Overall 5-year relative survival was 96.1% (95% CI 95.1-97.1%), being significantly lower in tumours of borderline (90.2%, 87.2-92.7%) than benign behaviour (97.4%, 96.3-98.3%). Benign tumour survival ranged from 86.8 for neurofibroma to 99.7% for Schwannoma; for borderline tumours survival rates varied from 83.2 for haemangiopericytoma to 98.4% for myxopapillary ependymoma. Cause of death was directly attributed to the CNS tumour in 39.6%, followed by other cancer (20.4%) and cardiovascular disease (15.8%).
  
  
  CONCLUSIONS
  The overall excess mortality in patients with non-malignant CNS tumours is 5.5%, indicating a significant improvement in survival over the last decade. Still, the remaining adverse impact on survival underpins the importance of systematic registration of these tumours.
authors.affiliation: Institute of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Woehrer
authors.affiliation: Austrian National Cancer Registry, Statistics Austria, Guglgasse 13, A-1110 Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Hackl
authors.affiliation: Center for Public Health, Department of Epidemiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Waldhör
authors.affiliation: Department of Pathology and Neuropathology, State Neuropsychiatric Hospital Wagner-Jauregg, Linz, Wagner-Jauregg-Weg 15, A-4020 Linz, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Weis
authors.affiliation: Internal Medicine and Neurooncology, State Neuropsychiatric Hospital Wagner-Jauregg, Wagner-Jauregg-Weg 15, A-4020 Linz, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Pichler
authors.affiliation: Department of Neurosurgery, State Neuropsychiatric Hospital Wagner-Jauregg, Wagner-Jauregg-Weg 15, A-4020 Linz, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Olschowski
authors.affiliation: Department of Neurosurgery, State Neuropsychiatric Hospital Wagner-Jauregg, Wagner-Jauregg-Weg 15, A-4020 Linz, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Buchroithner
authors.affiliation: Department of Neuropathology, Institute of Pathology, Medical University of Innsbruck, Christoph-Probst-Platz Innrain 52, A-6020 Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Maier
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Christoph-Probst-Platz Innrain 52, A-6020 Innsbruck, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Stockhammer
authors.affiliation: Department of Neurosurgery, Medical University of Innsbruck, Christoph-Probst-Platz Innrain 52, A-6020 Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Thomé
authors.affiliation: Department of Neuropathology, Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Haybaeck
authors.affiliation: Division of General Neurology and Division of Neuroradiology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Payer
authors.affiliation: Department of Neurosurgery, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria.
authors.forename: G
authors.initials: G
authors.lastname: von Campe
authors.affiliation: Institute of Pathology, State Hospital Klagenfurt, St Veiter Strasse 47, A-9020 Klagenfurt, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Kiefer
authors.affiliation: Institute of Pathology, State Hospital Klagenfurt, St Veiter Strasse 47, A-9020 Klagenfurt, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Würtz
authors.affiliation: Department of Neurosurgery, State Hospital Klagenfurt, St Veiter Strasse 47, A-9020 Klagenfurt, Austria.
authors.forename: G H
authors.initials: GH
authors.lastname: Vince
authors.affiliation: Department of Clinical Pathology, General Hospital St Pölten, Probst-Führer-Strasse 4, A-3100 St Pölten, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Sedivy
authors.affiliation: Department of Neurology, General Hospital St Pölten, Probst-Führer-Strasse 4, A-3100 St Pölten, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Oberndorfer
authors.affiliation: Department of Neurosurgery, General Hospital St Pölten, Probst-Führer-Strasse 4, A-3100 St Pölten, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Marhold
authors.affiliation: Department of Neurosurgery, Christian Doppler Clinic, Paracelsus Private Medical University, Strubergasse 21, A-5020 Salzburg, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Bordihn
authors.affiliation: Institute of Pathology, General Hospital Wiener Neustadt, Corvinusring 3-5, A-2700 Wiener Neustadt, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Stiglbauer
authors.affiliation: Department of Pathology, Feldkirch State Hospital, Carinagasse 47, A-6807 Feldkirch, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Gruber-Mösenbacher
authors.affiliation: Department of Neurosurgery, Feldkirch State Hospital, Carinagasse 47, A-6807 Feldkirch, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Bauer
authors.affiliation: Department of Pathology, Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030 Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Feichtinger
authors.affiliation: Institute of Pathology, Danube Hospital, Langobardenstrasse 122, A-1220 Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Reiner-Concin
authors.affiliation: Department of Neurology, KFJ-Hospital Vienna, Kundratstrasse 3, A-1100 Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Grisold
authors.affiliation: Department of Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Marosi
authors.affiliation: Department of Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Preusser
authors.affiliation: Department of Radiation Oncology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Dieckmann
authors.affiliation: Department of Paediatrics, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: I
authors.initials: I
authors.lastname: Slavc
authors.affiliation: Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Gatterbauer
authors.affiliation: Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Widhalm
authors.affiliation: Institute of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Haberler
authors.affiliation: Institute of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Vienna, Austria.
authors.forename: J A
authors.initials: JA
authors.lastname: Hainfellner
mesh_terms: D000293:Adolescent; D000328:Adult; D001317:Austria / Q000453:epidemiology; D002493:Central Nervous System Diseases / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D015996:Survival Rate; D055815:Young Adult