title: [Plasma testosterone, obesity, metabolic syndrome and diabetes].
abstract: The frequency of diabetes and/or metabolic syndrome rises concurrently with that of body mass index (BMI). In adult men, plasma testosterone level changes evolve inversely to that of BMI. Plasma total testosterone, sex hormone-binding globulin (SHBG) and free testosterone are significantly lower in adult men with a clinical and biological pattern of metabolic syndrome (MetS) than in those without such a pattern. After adjustment for confounding factors, diabetes type 2 (DT2) remains associated with a significant decrease of plasma testosterone level. The androgenic blockade, used as a treatment for disseminated prostate cancer, induces a metabolic pattern similar to MetS. In men older than 65 years, a decrease of plasma testosterone level is associated with an increased risk of stroke or of death linked to a cardiovascular event. After exclusion of contraindications, the substitution with androgens of a demonstrated hypogonadism in a obese patient, notably when obesity is associated with a pattern of MetS and/or a DT2, could have some metabolic and cardiovascular advantages.
authors.affiliation: CHU de Rouen, hôpital Bois-Guillaume, service d'endocrinologie, diabète et maladies métaboliques, 76230 Bois-Guillaume, France. Electronic address: gaetan.prevost@chu-rouen.fr.
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Prévost
authors.affiliation: CHU de Rouen, hôpital Bois-Guillaume, service d'endocrinologie, diabète et maladies métaboliques, 76230 Bois-Guillaume, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Eas
authors.affiliation: CHU de Rouen, hôpital Bois-Guillaume, service d'endocrinologie, diabète et maladies métaboliques, 76230 Bois-Guillaume, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005058:Eunuchism / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone