title: Oral glycopyrrolate for refractory pediatric and adolescent hyperhidrosis.
abstract: Primary hyperhidrosis is a common disorder affecting children and adolescents, and it can have a significant negative psychosocial effect. Treatment for pediatric hyperhidrosis tends to be limited by low efficacy, low adherence, and poor tolerance. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children. We present an institutional review of 12 children with severe, refractory hyperhidrosis treated with oral glycopyrrolate; 11 (92%) noted improvement and 9 (75%) would recommend oral glycopyrrolate to their friends. No significant side effects were noted. Our retrospective analysis suggests that oral glycopyrrolate is safe and effective in children with hyperhidrosis.
authors.affiliation: Division of Dermatology, Departments of Internal Medicine and Pediatrics, School of Medicine, Washington University and St. Louis Children's Hospital, St. Louis, Missouri.
authors.forename: Monique G
authors.initials: MG
authors.lastname: Kumar
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Foreman
authors.forename: David R
authors.initials: DR
authors.lastname: Berk
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bayliss
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage*; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018727:Muscarinic Antagonists; D006024:Glycopyrrolate