title: Effect of citrate phosphate dextrose solution on reperfusion injury in coronary artery bypass surgical patients undergoing cardiopulmonary bypass.
abstract: BACKGROUND
  Reperfusion injury is one of the most common phenomena associated with coronary artery bypass graft (CABG) .The mechanism of ischemia and reperfusion injury is not known precisely, but may be free radicals and other activated oxygen metabolites have an important role in tissue damage following reperfusion injury. This study was to evaluation of citrate solution effects on oxidative stress and cardiac function and Cardiac enzymes in patient's candidate to CABG.
  
  
  METHODS
  In Double blind clinical trial study in Tabriz University of medical science, 50 patients candidate to CABG randomly divided in two groups and matched together according to sex, age and NYHA class. In intervention group after surgery and before the opening of the aortic clamping solution warm blood containing citrate phosphate dextrose (CPD; 3cc/100cc), value (100cc/min/m2BSA) for three minutes was administered. In control group, only pure blood administered. Oxidative stress markers measured in five stages and cardiac enzymes measured in three stages of surgery.
  
  
  RESULTS
  Mean age 62.3±9.1 years including 30(60%) men and 20(40%) women. Ejection fractions between two groups were not significant before and after treatment. Administration of CPD was not significant effects on cardiac enzyme. Measurement of oxidative stress in different time were not different in malonil dialdehyde, superoxide dismutase and GPx but total antioxidant status were improved after intervention in compared with control group (p<0.001).
  
  
  CONCLUSIONS
  Results showed that CPD were positive effects of increasing in total antioxidant status after CABG, but in reduction of other oxidative markers were unlabeled.
authors.affiliation: Cardiovascular Research Center, Shahid Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Yaghoubi
authors.forename: Saeid
authors.initials: S
authors.lastname: Danaee
authors.forename: Shahin
authors.initials: S
authors.lastname: Imani
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Sheikhalizadeh
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
keywords: Coronary Artery Bypass Graft; Oxidative Stress; Reperfusion Injury