title: Risk factors for long-term outcomes after initial treatment in hepatolithiasis.
abstract: Hepatobiliary complications, such as stone recurrence, recurrent cholangitis, liver abscess, secondary biliary cirrhosis, and cholangiocarcinoma may occur after treatment for hepatolithiasis. However, few previous studies have addressed the risk factors and long-term outcomes after initial treatment. Eighty-five patients with newly diagnosed hepatolithiasis, actively treated for hepatolithiasis, constituted the cohort of this retrospective study. Patients were treated by hepatectomy or nonoperative percutaneous transhepatic cholangioscopic lithotomy. Long-term complications, such as recurrent cholangitis, liver abscess, secondary biliary cirrhosis, and cholangiocarcinoma, and their relationships with clinical parameters were analyzed. The mean follow-up period was 57.4 months. The overall hepatobiliary complication rate after the treatment was 17.6%. Multivariate analysis of suspected risk factors showed that complications were associated with age (HR, 1.046; CI, 1.006-1.089), bile duct stricture (HR, 4.894; CI, 1.295-18.495), and residual stones (HR, 3.482; CI, 1.214-9.981). In conclusion, several long-term hepatobiliary complications occur after hepatolithiasis treatment, and regular observation is necessary in patients with concomitant biliary stricture or residual stones.
authors.affiliation: Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
authors.forename: Jin-Seok
authors.initials: JS
authors.lastname: Park
authors.forename: Seok
authors.initials: S
authors.lastname: Jeong
authors.forename: Don Haeng
authors.initials: DH
authors.lastname: Lee
authors.forename: Byoung Wook
authors.initials: BW
authors.lastname: Bang
authors.forename: Jung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Kye Sook
authors.initials: KS
authors.lastname: Kwon
authors.forename: Hyung Kil
authors.initials: HK
authors.lastname: Kim
authors.forename: Yong Woon
authors.initials: YW
authors.lastname: Shin
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Shin Goo
authors.initials: SG
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D001659:Biliary Tract; D001662:Biliary Tract Surgical Procedures; D002780:Cholestasis, Intrahepatic / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D042882:Gallstones / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Bile Ducts; Cholelithiasis; Complication; Intrahepatic; Risk Factors