title: Encephalocele following a periconceptional exposure to efavirenz: a case report.
abstract: The use of Efaverinz in reproductive age women needs caution as its use in the first trimster of pregnancy is reportedly associated with an increased risk of neural tube defect (NTD) in the newborn. This concern is based on evidence from animal studies and two human case reports. We report here yet another case of encephalocele born from a mother who was taking efaverenze during conception and the first 8 weeks of gestation, the critical time in the pathogenesis of NTDs.
authors.affiliation: Department of Gynecology and Obstetrics, Karamara Referral Hospital, Jigjiga, Ethiopia.
authors.forename: W
authors.initials: W
authors.lastname: Gudu
authors.forename: D
authors.initials: D
authors.lastname: Bekele
mesh_terms: D000328:Adult; D000480:Alkynes; D048588:Benzoxazines / Q000009:adverse effects*; D003521:Cyclopropanes; D004677:Encephalocele / Q000139:chemically induced*; D005260:Female; D005313:Fetal Death; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*
chemical_list: D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz