title: Phenytoin-Associated Granulomatous Pulmonary Vasculitis.
abstract: Phenytoin was introduced in 1938 for the control of seizure disorders and remains widely used today. Since that time, many cases of phenytoin-induced allergic reactions and clinical pulmonary disease have been reported. However, pulmonary vascular pathology from phenytoin use has been only very rarely described. We report a case of phenytoin-associated vasculitis in a 39-year-old African American man presenting with progressive dyspnea and abnormal chest imaging. The importance of reviewing the medication history along with familiarity with the array of drug-associated lung diseases is crucial to recognize and treat pneumotoxicity.
authors.affiliation: 1Department of Pulmonary Diseases, Critical Care, and Environmental Medicine, School of Medicine, Tulane University Health Sciences Center New Orleans, LA; and 2Department of Pathology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Fayez
authors.initials: F
authors.lastname: Kheir
authors.forename: Philip
authors.initials: P
authors.lastname: Daroca
authors.forename: Joseph
authors.initials: J
authors.lastname: Lasky
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008213:Lymphocyte Activation; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin