title: Toscana virus infections: a case series from France.
abstract: Toscana virus (TOSV) is a neglected sandfly-borne pathogen in Mediterranean countries. Although discovered four decades ago, articles that describe the clinical aspects are scarce and consist mostly of case reports, with few series of cases. We studied retrospectively symptomatic TOSV infections in patients hospitalized in Marseille (France) from 2004 to 2011. Seventeen patients were classified as probable or confirmed cases. Fourteen cases (82%) occurred between June and September, and 3 cases in March, April and November. Two cases were potentially imported from Croatia and Tuscany. All patients presented with fever and neurological signs were observed such as aseptic meningitis (n = 6), muscular symptoms (n = 3), or encephalitis (n = 4). The outcome was always favorable. At the acute stage, anti TOSV IgM were observed in 14/17 patients, neutralization tests were positive for 3/8 patients, and RT-PCR confirmed TOSV infections in 5/8 CSF specimens.
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Dupouey
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Bichaud
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Ninove
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Zandotti
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Thirion-Perrier
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.
authors.forename: X
authors.initials: X
authors.lastname: de Lamballerie
authors.affiliation: UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France. Electronic address: remi.charrel@univ-amu.fr.
authors.forename: R N
authors.initials: RN
authors.lastname: Charrel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002044:Bunyaviridae Infections; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever; D005602:France; D006801:Humans; D008297:Male; D008587:Meningitis, Viral; D008875:Middle Aged; D058069:Neglected Diseases; D029301:Sandfly fever Naples virus; D055815:Young Adult
keywords: Arbovirus; Emerging; Fever; Meningitis; Phlebovirus