title: Evaluating the effect of zingiber officinalis on nausea and vomiting in patients receiving Cisplatin based regimens.
abstract: Ginger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. For evaluating the effect of zingiber officinalis on nausea and vomiting (N and V) in patients receiving cisplatin based regimens, a randomized double-blind placebo-controlled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherapeutic agents. The patients were randomly assigned to receive ginger capsules (rhizome of zingiber officinalis) or placebo in their first cycle of the study. All patients received standard antiemetics for chemotherapy induced nausea and vomiting (CINV). The patients were crossed-over to receive ginger or placebo in their next cycle of chemotherapy. Among 36 eligible patients who received both cycles of treatment, there were no difference in prevalence, severity, and duration of both acute and delayed N and V. Addition of ginger to the standard antiemetic regimen has shown no advantage in reducing acute and delayed N and V in patients with cisplatin-based regimen in this study.
authors.affiliation: Pharmaceutical Care Department, Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fanak
authors.initials: F
authors.lastname: Fahimi
authors.forename: Kian
authors.initials: K
authors.lastname: Khodadad
authors.forename: Somayeh
authors.initials: S
authors.lastname: Amini
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Naghibi
authors.forename: Jamshid
authors.initials: J
authors.lastname: Salamzadeh
authors.forename: Shadi
authors.initials: S
authors.lastname: Baniasadi
keywords: Chemotherapy; Cisplatin; Ginger; Nausea; Vomiting