title: Long-term fundus changes in acquired partial lipodystrophy.
abstract: We describe long-term fundus changes in a patient with partial lipodystrophy (PL). Retinal pigment alterations, drusen and subretinal neovascularisation were seen without evidence for membranoproliferative glomerulonephritis. Fundus alterations similar to those seen in age-related macular degeneration can occur at an earlier age in patients with PL, even without renal disease. Dysregulation of an alternative complement pathway with low serum levels of C3 has been implicated as a pathogenetic mechanism.
authors.affiliation: University Hospitals Leuven, Leuven, Belgium.
authors.forename: Joyce
authors.initials: J
authors.lastname: Jansen
authors.forename: Lien
authors.initials: L
authors.lastname: Delaere
authors.forename: Leigh
authors.initials: L
authors.lastname: Spielberg
authors.forename: Anita
authors.initials: A
authors.lastname: Leys
mesh_terms: D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis*; D006801:Humans; D008060:Lipodystrophy / Q000150:complications*; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D012160:Retina / Q000473:pathology*; D015593:Retinal Drusen / Q000175:diagnosis*