title: Ultrasound assessment of bladder wall thickness as a screening test for detrusor instability.
abstract: OBJECTIVE
  The aim of the current study was to evaluate the diagnostic accuracy of transvaginal ultrasound measurement of bladder wall thickness (BWT) in diagnosis of over active bladder (OAB).
  
  
  METHODS
  The current prospective study was conducted at Ain Shams University Maternity Hospital over 2 years. Patients presented to the urogynecology outpatient clinic with symptoms of urinary frequency, urgency, nocturia and/or urge incontinence were included in this study. The allocated patients were divided into two groups; Group 1(study group): fifty (50) patients with urodynamic diagnosis of detrusor instability (OAB) were included. Group 2 (control): fifty (50) patients with urodynamic diagnosis of stress incontinence were included. Using a transvaginal probe, BWT was measured in three sites at the thickest part of (a) the dome of the bladder (b) the trigone, and (c) the anterior wall of the bladder. An average of the three measurements was considered as the mean bladder thickness.
  
  
  RESULTS
  A total of 100 patients with lower urinary symptoms were finally analyzed. There were no statistical significant differences between both groups regarding age, parity and body mass index, while there was statistically longer disease duration in group 2. Excluding urgency, there was statistical significant difference (P < 0.001) regarding lower urinary tract symptoms namely frequency, urgency incontinence, coital incontinence and nocturia. Patients in group 1 were more positive to symptoms of frequency, urgency incontinence, and nocturia, while patients in group 2 were more positive regarding coital incontinence. The thickness of trigon, dome, anterior wall and mean BWT was significantly higher in group 1 when compared to group 2. Receiver operator characteristics curve was constructed for estimating the association between mean BWT and prediction of OAB in patients with lower urinary tract symptoms. Mean BWT at 4.78 mm was considered as best cut-off value for prediction of OAB with sensitivity of 90 % and specificity of 78 %. Mean BWT was significantly associated with OAB > 4.78 mm as denoted by the significantly large area under the curve [AUC], AUC was 0.905.
  
  
  CONCLUSIONS
  In women with lower urinary tract symptom, transvaginal ultrasounds measured mean BWT seems to be an effective non invasive diagnostic tool for prediction of OAB.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, migoa1@hotmail.com.
authors.forename: Amgad
authors.initials: A
authors.lastname: Abou-Gamrah
authors.forename: Mounir
authors.initials: M
authors.lastname: Fawzy
authors.forename: Hazem
authors.initials: H
authors.lastname: Sammour
authors.forename: Sherif
authors.initials: S
authors.lastname: Tadros
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008875:Middle Aged; D010298:Parity; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods*; D001743:Urinary Bladder / Q000000981:diagnostic imaging*; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D053202:Urinary Incontinence, Urge / Q000000981:diagnostic imaging*; D014563:Urodynamics