title: Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.
abstract: Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital Memphis, TN, USA.
authors.forename: R K Subbarao
authors.initials: RK
authors.lastname: Malireddi
authors.forename: Thirumala-Devi
authors.initials: TD
authors.lastname: Kanneganti
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000473:pathology; D016923:Cell Death; D054884:Host-Pathogen Interactions; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism*; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism*; D009181:Mycoses / Q000276:immunology / Q000473:pathology; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology
chemical_list: D058847:Inflammasomes; D007370:Interferon Type I
keywords: IFNβ; NLR; Nlrp3; caspase-1; cell death; inflammasome; type I IFN