title: Long-term hip simulator testing of the artificial hip joint bearing surface grafted with biocompatible phospholipid polymer.
abstract: To prevent periprosthetic osteolysis and subsequent aseptic loosening of artificial hip joints, we recently developed a novel acetabular highly cross-linked polyethylene (CLPE) liner with graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) on its surface. We investigated the wear resistance of the poly(MPC) (PMPC)-grafted CLPE liner during 20 million cycles in a hip joint simulator. We extended the simulator test of one liner to 70 million cycles to investigate the long-term durability of the grafting. Gravimetric, surface, and wear particle analyses revealed that PMPC grafting onto the CLPE liner surface markedly decreased the production of wear particles and showed that the effect of PMPC grafting was maintained through 70 million cycles. We believe that PMPC grafting can significantly improve the wear resistance of artificial hip joints.
authors.affiliation: Division of Science for Joint Reconstruction, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Sensory & Motor System Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Moro
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takatori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kyomoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Masami
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hideya
authors.initials: H
authors.lastname: Ito
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Oshima
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
mesh_terms: D001672:Biocompatible Materials; D006622:Hip Prosthesis; D006801:Humans; D008689:Methacrylates; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D020959:Polyethylene; D011475:Prosthesis Failure; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; D020959:Polyethylene
keywords: artificial hip joint; aseptic loosening; periprosthetic osteolysis; total hip arthroplasty