title: Strain differences in kidney copper concentrations of male rats.
abstract: The copper concentrations of the kidneys of male rats of six inbred (BN, F344, LEW, SHR, WAG/Cpb, and WAG/Rij) and one random-bred Wistar strain were determined.In inbred rats the mean concentration varied between strains and ranged from 7.10 μg/g for F 344 to 23.48 μg/g for WAG/Cpb. The calculated coefficient of genetic determination (g(2)) was 0.88. A remarkable discrepancy was found between the two WAG inbred strains; the WAG/Cpb had a 2.5 times higher kidney Cu concentration than the WAG/Rij.Kidney Cu concentrations of random-bred rats varied considerably; the coefficient of variation of the means was 28 and 34% in two samples taken with a 1-yr interval, respectively, indicating inhomogeneity within the population.The results indicate that the individual differences in kidney Cu concentration have a genetic basis.
authors.affiliation: Department of Pathology, Faculty of Veterinary Science, State University, Utrecht, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Nederbragt
authors.forename: L F
authors.initials: LF
authors.lastname: van Zutphen