title: Pd-catalyzed desymmetric intramolecular O-arylation reaction: enantioselective synthesis of (3,4-dihydro-2H-chromen-3-yl)methanols.
abstract: An enantioselective intramolecular O-arylation was achieved through desymmetrization with Pd-catalyzed coupling reactions. The intramolecular asymmetric aryl C-O coupling reactions of 2-(2-haloaryl)propane-1,3-diols led to the enantioselective formation of chiral (3,4-dihydro-2H-chromen-3-yl)methanols in good yields and high enantiomeric selectivity.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , No. 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530, China, State Key Laboratory of Elemento-organic Chemistry, Nankai Univeristy , No. 94 Weijin Road, Tianjin, 300071, China, and College of Chemistry and Chemical Engineering, Hunan Normal University , No. 36 Lushan Road, Changsha, Hunan, 410081, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Yang
authors.forename: Jiajie
authors.initials: J
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Long
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.forename: Jianguang
authors.initials: J
authors.lastname: Liu
authors.forename: Youlin
authors.initials: Y
authors.lastname: Zeng
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D000432:Methanol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001578:Benzopyrans; D010165:Palladium; D000432:Methanol