title: EN2: a novel prostate cancer biomarker.
abstract: Extensive efforts to identify a clinically useful biomarker for the diagnosis of prostate cancer have resulted in important insights into the biology of the disease, but no new test has been approved by regulatory authorities. The unmet need has also shifted to identifying biomarkers that not only diagnose prostate cancer but also indicate whether the patient has 'significant' disease. EN2 is a homeobox-containing transcription factor secreted specifically by prostate cancers into urine, where it can be detected by a simple ELISA assay. A number of studies have demonstrated the enormous potential of EN2 to address this unmet need and provide the urologist with a simple, cheap and efficient prostate cancer biomarker.
authors.affiliation: Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7WG, UK.
authors.forename: Sophie E
authors.initials: SE
authors.lastname: McGrath
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Michael
authors.forename: Richard
authors.initials: R
authors.lastname: Morgan
authors.forename: Hardev
authors.initials: H
authors.lastname: Pandha
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D014408:Biomarkers, Tumor / Q000652:urine*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000652:urine*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D012307:Risk Factors; D000099266:Engrailed 2 Protein
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000099266:Engrailed 2 Protein