title: In vivo pH monitoring using boron doped diamond microelectrode and silver needles: application to stomach disorder diagnosis.
abstract: This study presents the in vivo electrochemical monitoring of pH using boron doped diamond (BDD) microelectrode and silver needles for potential application in medical diagnosis. Accurate calibration curve for pH determination were obtained through in vitro electrochemical measurements. The increase induced in stomach pH by treatment with pantoprazole was used to demonstrate that it is possible to monitor the pH in vivo using the simple and noninvasive system proposed herein. Using the results of the in vivo and in vitro experiments, a quantitative analysis of the increase in stomach pH is also presented. It is proposed that the catheter-free pH monitoring system presented in this study could be potentially employed in any biological environment.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Fierro
authors.forename: Ryo
authors.initials: R
authors.lastname: Seishima
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Saya
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Einaga
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000818:Animals; D001895:Boron / Q000737:chemistry; D018130:Diamond / Q000737:chemistry; D055664:Electrochemical Techniques; D050782:Esophageal pH Monitoring; D051379:Mice; D008839:Microelectrodes; D009339:Needles; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012834:Silver / Q000737:chemistry; D013272:Stomach Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000662:veterinary
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D012834:Silver; D018130:Diamond; D000077402:Pantoprazole; D001895:Boron