title: Zinc-mediated addition of diethyl bromomalonate to alkynes for the cascade reaction towards polysubstituted pyranones and tetracarbonyl derivatives.
abstract: The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction sequence.
authors.affiliation: Fachbereich Chemie, Hans-Meerwein-Str., 35043 Marburg, Germany. Hilt@chemie.uni-marburg.de.
authors.forename: Anne
authors.initials: A
authors.lastname: Miersch
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hilt