title: Effect of exercise training on long-term potentiation and NMDA receptor channels in rats with cerebral infarction.
abstract: The aim of the present study was to investigate the effects of exercise training on the characteristics of long-term potentiation (LTP) and N-methyl-D aspartate (NMDA) receptor channels in the hippocampal CA3 neurons of rats with cerebral infarction. Wistar rats were randomly allocated into the model without any training and rehabilitation with exercise training. A model of cerebral infarction was established by middle cerebral artery occlusion. Using chronically embedded electrodes combined with an electrophysiological method, the population spike (PS) amplitude and latency, as well as changes in the NMDA single channel current in the hippocampal neurons were determined prior to and following Y-maze discrimination learning 60 times in the two groups. The formation of learning-dependent LTP and synaptic efficacy in the hippocampal CA3 area after exercise training in the rehabilitation group was significantly faster compared with that in the model group without any training (P<0.05). The incubation period of the PS in the CA3 area of the rats in the rehabilitation group was significantly shorter compared with that in the model group. The PS amplitude in the rehabilitation group was significantly higher compared with that in the model group. Furthermore, the opening probability of the NMDA receptor channel in the rehabilitation group was significantly higher compared with that in the model group. In conclusion, exercise training improved the opening conductance level, time and probability of NMDA receptor channels and accelerated the formation of learning-dependent LTP in the contralateral hippocampal CA3 area.
authors.affiliation: Department of Rehabilitation, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Li
keywords: N-methyl-D aspartate receptor channel; cerebral infarction; exercise training; long-term potentiation