title: Radiation-associated meningioma in the elderly: development of meningioma with olfactory neuroblastoma recurrence 10 years after irradiation.
abstract: The pathogenesis of meningiomas is not established [1,2]. However, intracranial irradiation in childhood is a risk factor for the development of meningiomas later in life [2-6]. Children treated with irradiation for tinea capitis of the scalp showed an almost ten-fold increase in development of meningiomas relative to age-matched controls [2,3]. In a study of almost 18,000 children who survived for at least five years after receiving external beam radiation, 2.3% developed meningiomas within 17 years of follow-up [5]. Notably, meningioma formation after radiation therapy (RT) occurs almost exclusively in patients irradiated as children or young adults. Development of a radiation-associated meningioma (RAM) in patients who received RT in the sixth or seventh decade is very rare. For example, in studies including a total of 58 adults receiving RT, only two cases of RAM occurred in patients 50 years old or older [8,9].
authors.affiliation: Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave. Box 626, Rochester, NY 14642, USA; phone: 585 276 3087; fax: 585 273 1027; e mail: mahlon_johnson@urmc.rochester.edu.
authors.forename: Mahlon D
authors.initials: MD
authors.lastname: Johnson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Piech
authors.forename: Seyed
authors.initials: S
authors.lastname: Emandian
mesh_terms: D000368:Aged; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*
keywords: meningioma; olfactory neuroblastoma; radiation