title: Lack of Association Between Variants within the AHSG , HCRT and NPY2R Genes and Anthropometrical Parameters in Czech Post-Monica Study.
abstract: The aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes α 2-Heremans-Schmid glycoprotein ( AHSG , rs4917), Hypocretin ( HCRT , rs760282) and Neuropetide Y2 receptor (NPY2R , rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population ( p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG , HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.
authors.affiliation: Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Jurcikova
authors.forename: V
authors.initials: V
authors.lastname: Adamkova
authors.forename: V
authors.initials: V
authors.lastname: Lanska
authors.forename: P
authors.initials: P
authors.lastname: Suchanek
authors.forename: Ja
authors.initials: J
authors.lastname: Hubacek
keywords: Body mass index (BMI); Hypocretin  (  HCRT  ) gene; Neuropetide Y2 receptor  (  NPYR  ) gene; single nucleotide polymorphism (SNP); α  2-Heremans-Schmid glycoprotein  (  AHSG  ) gene