title: Molecular diagnosis of hematopoietic neoplasms.
abstract: Cytogenetic abnormalities are considered to be common events in hematologic malignancies. These abnormalities generally consist of structural chromosomal abnormalities or gene mutations, which often are integral to the pathogenesis and subsequent evolution of an individual malignancy. Improvements made in identifying and interpreting these molecular alterations have resulted in advances in the diagnosis, prognosis, monitoring, and therapy for cancer. As a consequence of the increasingly important role of molecular testing in hematologic malignancy management, this article presents an update on the importance and use of molecular tests, detailing the advantages and disadvantages of each test when applicable.
authors.affiliation: Department of Hematology/Oncology, Karmanos Cancer Institute, Detroit Medical Center, Wayne State University, 3990 John R, Detroit, MI 48201, USA.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Ramchandren
authors.forename: Tarek
authors.initials: T
authors.lastname: Jazaerly
authors.forename: Ali M
authors.initials: AM
authors.lastname: Gabali
mesh_terms: D019337:Hematologic Neoplasms / Q000175:diagnosis*; D006801:Humans; D025202:Molecular Diagnostic Techniques
keywords: Cytogenetic testing; Genetic aberrations; Hematopoietic neoplasms; Molecular testing