title: In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole.
abstract: A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)2(H2O)2] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible.
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.
authors.forename: Marta E
authors.initials: ME
authors.lastname: López-Viseras
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Avenida del Conocimiento S.N., Armilla, Granada, Spain. Electronic address: belenfernandez@ipb.csic.es.
authors.forename: Belén
authors.initials: B
authors.lastname: Fernández
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Avenida del Conocimiento S.N., Armilla, Granada, Spain.
authors.forename: Sabine
authors.initials: S
authors.lastname: Hilfiker
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos y Departamento de Fisiología, Campus Cartuja, Universidad de Granada, 18071 Granada, Spain. Electronic address: crissg@ugr.es.
authors.forename: Cristina Sánchez
authors.initials: CS
authors.lastname: González
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos y Departamento de Fisiología, Campus Cartuja, Universidad de Granada, 18071 Granada, Spain.
authors.forename: Juan Llopis
authors.initials: JL
authors.lastname: González
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain. Electronic address: antonio5@ugr.es.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Calahorro
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Colacio
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Diéguez
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004435:Eating / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D011720:Pyrazoles / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D011720:Pyrazoles; C031280:pyrazole; D015032:Zinc
keywords: Antidiabetic activity; Coordination compound; in vitro toxicity