title: Widespread dissemination of CTX-M-15 genotype extended-spectrum-β-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States.
abstract: Extended-spectrum-β-lactamase (ESBL)-producing organisms are increasingly prevalent. We determined the characteristics of 66 consecutive ESBL-producing isolates from six community hospitals in North Carolina and Virginia from 2010 to 2012. Fifty-three (80%) ESBL-producing isolates contained CTX-M enzymes; CTX-M-15 was found in 68% of Escherichia coli and 73% of Klebsiella isolates. Sequence type 131 (ST131) was the commonest type of E. coli, accounting for 48% of CTX-M-15-producing and 66% of CTX-M-14-producing isolates. In conclusion, the CTX-M genotype and ST131 E. coli were common among ESBL isolates from U.S. community hospitals.
authors.affiliation: Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Luke F
authors.initials: LF
authors.lastname: Chen
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Freeman
authors.forename: Brad
authors.initials: B
authors.lastname: Nicholson
authors.forename: Anna
authors.initials: A
authors.lastname: Keiger
authors.forename: Sarah
authors.initials: S
authors.lastname: Lancaster
authors.forename: Maria
authors.initials: M
authors.lastname: Joyce
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Woods
authors.forename: Evelyn
authors.initials: E
authors.lastname: Cook
authors.forename: Linda
authors.initials: L
authors.lastname: Adcock
authors.forename: Susan
authors.initials: S
authors.lastname: Louis
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Cromer
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sexton
authors.forename: Deverick J
authors.initials: DJ
authors.lastname: Anderson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D015870:Gene Expression; D006764:Hospitals, Community; D006801:Humans; D007709:Klebsiella / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D009657:North Carolina / Q000453:epidemiology; D014768:Virginia / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases