title: Fracture toughness of heat cured denture base acrylic resin modified with Chlorhexidine and Fluconazole as bioactive compounds.
abstract: OBJECTIVE
  This study investigated the impact of incorporating Chlorhexidine and Fluconazole as bioactive compounds on the fracture toughness of conventional heat cured denture base acrylic resin material (PMMA).
  
  
  METHODS
  30 single edge-notched (SEN) samples were prepared and divided into three groups. 10% (mass) Chlorhexidine and 10% (mass) Diflucan powder (4.5% mass Fluconazole) were added to heat cured PMMA respectively to create the two study groups. A third group of conventional heat cured PMMA was prepared as the control group. Fracture toughness (3-point bending test) was carried out for each sample and critical force (Fc) and critical stress intensity factor (KIC) values measured. Data were subject to parametric statistical analysis using one-way ANOVA and Post hoc Bonferroni test (p=0.05).
  
  
  RESULTS
  Fluconazole had no significant effect on the fracture toughness of the PMMA while Chlorhexidine significantly reduced the KIC and therefore affected the fracture toughness.
  
  
  CONCLUSIONS
  When considering addition of a bioactive material to PMMA acrylic, Chlorhexidine will result in reduced fracture toughness of the acrylic base while Fluconazole has no effect.
authors.affiliation: Research Student, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester M13 9PL, United Kingdom.
authors.forename: Alaa
authors.initials: A
authors.lastname: Al-Haddad
authors.affiliation: Clinical Lecturer and Honorary Speciality Registrar in Restorative Dentistry, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester M13 9PL, United Kingdom. Electronic address: reza@manchester.ac.uk.
authors.forename: Reza
authors.initials: R
authors.lastname: Vahid Roudsari
authors.affiliation: Professor in Restorative Dentistry, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester M13 9PL, United Kingdom.
authors.forename: Julian D
authors.initials: JD
authors.lastname: Satterthwaite
mesh_terms: D000465:Algorithms; D000891:Anti-Infective Agents, Local / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D002710:Chlorhexidine / Q000737:chemistry*; D003764:Dental Materials / Q000737:chemistry*; D003799:Dental Stress Analysis / Q000295:instrumentation; D003819:Denture Bases; D015725:Fluconazole / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D018583:Pliability; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D003764:Dental Materials; D015725:Fluconazole; D019904:Polymethyl Methacrylate; D002710:Chlorhexidine
keywords: Acrylic resin; Bioactive compound; Chlorhexidine; Denture; Fluconazole; Fracture toughness