title: Hepatocellular carcinoma and other liver lesions.
abstract: Patients with cirrhosis are at greatest risk for development of hepatocellular carcinoma (HCC) and should undergo semiannual surveillance using ultrasound, with or without alpha fetoprotein. Patients with positive surveillance testing should undergo contrast-enhanced MRI or 4-phase CT for diagnostic evaluation. There are therapeutic options for most patients with any tumor stage; however, treatment decisions must be individualized after accounting for degree of liver dysfunction and patient performance status. A multidisciplinary approach to care is recommended for optimal communication and treatment delivery. The aim of this review is to provide an up-to-date summary of the diagnosis and management of HCC.
authors.affiliation: Division of Gastroenterology and Hepatology, Henry Ford Hospital, 2799 West Grand Boulevard, Suite K7, Detroit, MI 48202, USA.
authors.forename: Reena
authors.initials: R
authors.lastname: Salgia
authors.forename: Amit G
authors.initials: AG
authors.lastname: Singal
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D019468:Disease Management; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000503:physiopathology; D011379:Prognosis; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins
keywords: Diagnosis; Liver cancer; Liver mass; Treatment