title: Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China.
abstract: OBJECTIVE
  To investigate the association of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene polymorphisms with gastric cancer in Chinese Han population in central China.
  
  
  METHODS
  A total of 304 patients with gastric cancer confirmed by histopathology and 421 unrelated healthy controls were studied. Gene polymorphisms of TRAIL (G1525A and C1595T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  The frequency of the genotype carriers of TRAIL 1525A (GA + AA) and 1595T (CT + TT) was significantly lower in gastric cancer than in healthy controls (37.2% vs. 61.5%, P < 0.001, OR = 0.581, 95% CI 0.442 ~ 0.764; 36.2% vs. 62.0%, P < 0.001, OR = 0.570, 95% CI 0.433 ~ 0.750, respectively). Stratification analysis showed that both TRAIL 1525A (GA + AA) and 1595T (CT + TT) carriers were associated with poorly-differentiated gastric cancer compared to 1525GG genotype and 1595CC genotype (OR = 0.516, 95%CI 0.279 ~ 0.957, P = 0.026; OR = 0.395, 95%CI 0.207 ~ 0.753, P = 0.004, respectively).
  
  
  CONCLUSIONS
  TRAIL G1525A and C1595T gene polymorphisms were significantly correlated with the susceptibility to gastric cancer in Chinese Han population in central China.
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan, University School of Medicine, Donghu Road 169, Wuhan, 430071, Hubei Province, People's Republic of China.
authors.forename: Changgao
authors.initials: C
authors.lastname: Wang
authors.forename: Shufang
authors.initials: S
authors.lastname: Xu
authors.forename: Fengming
authors.initials: F
authors.lastname: Yi
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lei
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D017209:Apoptosis; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human