title: Combined intestine and kidney transplantation in a patient with encapsulating peritoneal sclerosis: case report.
abstract: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis characterized by fibrosis and calcification of the intestine that, in severe cases, can progress to intestinal failure and total parenteral nutrition dependency. Medical and surgical interventions carry a poor prognosis in these patients. We describe a case of a 36-year-old female with end-stage kidney disease and severe EPS not amenable to surgical intervention who underwent a combined intestinal and kidney transplantation. At 3 years posttransplantation, the patient has normal intestinal and kidney function. This represents, to our knowledge, the first report of severe EPS and end-stage kidney disease treated with a combined transplant.
authors.affiliation: Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH.
authors.forename: A
authors.initials: A
authors.lastname: Waghray
authors.forename: A
authors.initials: A
authors.lastname: Nassar
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: B
authors.initials: B
authors.lastname: Eghtesad
authors.forename: F
authors.initials: F
authors.lastname: Aucejo
authors.forename: V
authors.initials: V
authors.lastname: Krishnamurthi
authors.forename: T D
authors.initials: TD
authors.lastname: Uso
authors.forename: T
authors.initials: T
authors.lastname: Srinivas
authors.forename: E
authors.initials: E
authors.lastname: Steiger
authors.forename: K
authors.initials: K
authors.lastname: Abu-Elmagd
authors.forename: C
authors.initials: C
authors.lastname: Quintini
mesh_terms: D000328:Adult; D005260:Female; D005355:Fibrosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007422:Intestines / Q000637:transplantation*; D007676:Kidney Failure, Chronic / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D010530:Peritoneal Dialysis / Q000009:adverse effects; D056627:Peritoneal Fibrosis / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents
keywords: Encapsulating peritoneal sclerosis; intestinal transplant; kidney transplantation; peritoneal dialysis