title: Chemical study and larvicidal activity against Aedes aegypti of essential oil of Piper aduncum L. (Piperaceae).
abstract: Piper aduncum L. is used in folk medicine to treat respiratory and inflammatory diseases. The aim of this study was to analyze the essential oil from leaves of P. aduncum collected in the Brazilian Cerrado, North of Minas Gerais, as well as to evaluate the larvicidal activity of this oil and of its major constituent. The essential oil was analyzed by gas chromatography coupled to flame ionization detector and gas chromatography coupled to mass spectrometry that allowed characterizing 23 compounds (monoterpenes: 90.4%; sesquiterpenes: 7.0%). The major component was 1,8-cineole (53.9%). This oil showed to be very different from those obtained from the same species. Larvae of A. aegypti were exposed to different concentrations of the essential oil and 1,8-cineole. The mortality rate of 100% was obtained after 24 h of treatment with the oil at concentrations of 500 and 1,000 ppm. After 48 h of treatment, the mortality rate was 80% and 50% for concentrations of 250 and 100 ppm, respectively. The LC₅₀ obtained after 24h was estimated in 289.9 ppm and after 48 h was 134.1 ppm. The major compound 1,8-cineole showed no larvicidal activity.
authors.affiliation: Programa de Pós-Graduação em Biotecnologia Vegetal, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21941-590Rio de JaneiroRJ, Brasil.
authors.forename: Gisele L
authors.initials: GL
authors.lastname: Oliveira
authors.affiliation: Av. Nice, 99, Ibituruna, Ciências Biológicas, Faculdade de Saúde Ibituruna/ FASI, 39401-303Montes ClarosMG, Brasil.
authors.forename: Sheila K
authors.initials: SK
authors.lastname: Cardoso
authors.affiliation: Av. Nice, 99, Ibituruna, Ciências Biológicas, Faculdade de Saúde Ibituruna/ FASI, 39401-303Montes ClarosMG, Brasil.
authors.forename: Célio R
authors.initials: CR
authors.lastname: Lara
authors.affiliation: Av. Universitária, 1000, Bairro Universitário, Programa de Pós-Graduação em Ciências Agrárias, Universidade Federal de Minas Gerais, UFMG, 39404-006Montes ClarosMG, Brasil.
authors.forename: Thallyta M
authors.initials: TM
authors.lastname: Vieira
authors.affiliation: Rua Jardim Botânico, 1008, Jardim Botânico, Departamento de Botânica, Instituto de Pesquisa Jardim Botânico do Rio de Janeiro, 22460-030Rio de JaneiroRJ, Brasil.
authors.forename: Elsie F
authors.initials: EF
authors.lastname: Guimarães
authors.affiliation: Av. Universitária, 1000, Bairro Universitário, Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, UFMG, 39404-006Montes ClarosMG, Brasil.
authors.forename: Lourdes S
authors.initials: LS
authors.lastname: Figueiredo
authors.affiliation: Av. Universitária, 1000, Bairro Universitário, Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, UFMG, 39404-006Montes ClarosMG, Brasil.
authors.forename: Ernane R
authors.initials: ER
authors.lastname: Martins
authors.affiliation: Av. Sizenando Nabuco, 100, Manguinhos, Departamento de Produtos Naturais, Fundação Oswaldo Cruz, Fiocruz, Farmanguinhos, 21045-900Rio de JaneiroRJ, Brasil.
authors.forename: Davyson L
authors.initials: DL
authors.lastname: Moreira
authors.affiliation: Núcleo de Pesquisa de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, UFRJ, 21941-590Rio de JaneiroRJ, Brasil.
authors.forename: Maria Auxiliadora C
authors.initials: MA
authors.lastname: Kaplan
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D007306:Insecticides / Q000737:chemistry; D007814:Larva / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry; D013997:Time Factors
chemical_list: D007306:Insecticides; D010938:Plant Oils