title: Myenteric plexus is differentially affected by infection with distinct Trypanosoma cruzi strains in Beagle dogs.
abstract: Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model.
authors.affiliation: Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Nívia Carolina
authors.initials: NC
authors.lastname: Nogueira-Paiva
authors.affiliation: Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Kátia da Silva
authors.initials: Kda S
authors.lastname: Fonseca
authors.affiliation: Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Paula Melo de Abreu
authors.initials: PM
authors.lastname: Vieira
authors.affiliation: Laboratório de Doença de Chagas, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Lívia Figueiredo
authors.initials: LF
authors.lastname: Diniz
authors.affiliation: Laboratório de Doença de Chagas, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Ivo Santana
authors.initials: IS
authors.lastname: Caldas
authors.affiliation: Laboratório de Imunoparasitologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Sandra Aparecida Lima de
authors.initials: SA
authors.lastname: Moura
authors.affiliation: Departamento de Farmácia, Escola de Farmácia, Universidade Federal de Ouro Preto.
authors.forename: Vanja Maria
authors.initials: VM
authors.lastname: Veloso
authors.affiliation: Departamento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte, NatalRN, Brasil.
authors.forename: Paulo Marcos da Matta
authors.initials: PM
authors.lastname: Guedes
authors.affiliation: Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Washington Luiz
authors.initials: WL
authors.lastname: Tafuri
authors.affiliation: Laboratório de Doença de Chagas, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Maria Terezinha
authors.initials: MT
authors.lastname: Bahia
authors.affiliation: Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto.
authors.forename: Cláudia Martins
authors.initials: CM
authors.lastname: Carneiro
mesh_terms: D000210:Acute-Phase Reaction / Q000469:parasitology; D000818:Animals; D001344:Autopsy; D014355:Chagas Disease / Q000469:parasitology* / Q000473:pathology; D002908:Chronic Disease; D003092:Colitis / Q000469:parasitology; D003106:Colon / Q000469:parasitology* / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D004931:Esophageal Achalasia / Q000469:parasitology; D004941:Esophagitis / Q000469:parasitology; D004947:Esophagus / Q000469:parasitology* / Q000473:pathology; D008531:Megacolon / Q000469:parasitology; D009197:Myenteric Plexus / Q000469:parasitology*; D013045:Species Specificity; D014349:Trypanosoma cruzi / Q000145:classification*