title: The Association between Epicardial Adipose Tissue and Coronary Artery Disease: an Echocardiographic Cut-off Point.
abstract: BACKGROUND
  EAT is an independent factor in coronary artery disease (CAD). The objective of the current study was to define an echocardiographic cut-off point for EAT and to determine its diagnostic value in predicting the increase in CAD risk.
  
  
  METHODS
  Two hundred patients underwent coronary artery angiography for diagnosis of CAD and transthoracic echocardiography for measurement of EAT on the right ventricle (RV), RV apex and RV outlet tract. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the EAT cut-off points in the three above-mentioned areas for predicting the severity of CAD were measured. The relation between the EAT and CAD risk factors was evaluated as well.
  
  
  RESULTS
  EAT was independent from gender, height, hypertension, diabetes, HDL, total cholesterol, ejection fraction, acute coronary syndrome, and the location of the coronary artery stenosis in the coronary artery in all three anatomical areas. EAT on RV and RV apex had a significant relation with CAD (P ≤ 0.05). Overall, RV EAT≥ 10 mm and RV apex EAT ≥ 8 mm had sensitivity and PPV of more than 70% in predicting coronary stenosis ≥ 50% and acute coronary syndrome (ACS) and RVOT EAT ≥ 13 mm is of PPV=83.5% for predicting coronary stenosis ≥ 50%.
  
  
  CONCLUSIONS
  EAT thickness has an acceptable diagnostic value for predicting severe coronary artery stenosis and ACS. Therefore, non-invasive EAT thickness measurement could be of great assistance to clinicians for detecting the patients at risk and helping them to undergo supplementary evaluations with invasive approaches.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Toufan
authors.forename: Rasoul
authors.initials: R
authors.lastname: Azarfarin
authors.forename: Boshra
authors.initials: B
authors.lastname: Sadati
authors.forename: Samad Ej
authors.initials: SE
authors.lastname: Golzari
keywords: Coronary Artery Disease; Diagnostic Value; Epicardial Adipose Tissue; Predictive Value