title: A new method for the determination of partition coefficients of air sensitive copper(i) complexes.
abstract: Determinations of log P values of copper complexes in oil/water were performed in a new, totally closed apparatus connected with a filter-probe extractor. The results indicate that the system may be generally suitable for the determination of log P values of oxidizable and nonoxidizable metal complexes. In the case of the copper (I) complexes spectrophotometric analysis was not feasible, since 1-octanol was extracted by these complexes into the aqueous phase, resulting in a change in the extinction coefficient. To establish accurately the concentration in each phase, copper was determined by atomic absorption spectrometry.
authors.affiliation: Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.
authors.forename: H D
authors.initials: HD
authors.lastname: Gaisser
authors.forename: H
authors.initials: H
authors.lastname: van der Goot
authors.forename: H
authors.initials: H
authors.lastname: Timmerman