title: Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin.
abstract: The interpenetrating polymer networks (IPN) hydrogels based on chitosan and gelatin using genipin as the cross-linker were prepared and characterized. The IPN formation of the genipin-cross-linked chitosan/gelatin hydrogel was confirmed by means of the instrinsic viscosity measurement, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and the ninhydrin assays. The instrinsic viscosity measurement, FT-IR and SEM suggested that chitosan and gelatin were miscible in the molecular level. The miscibility leads to the formation of IPN after cross-linking. FT-IR also examined the cross-linking mechanism of genipin with primary amino groups. The degree of cross-linking increased with increase genipin concentration. Swelling results revealed that the IPN hydrogels are pH-sensitive, exhibiting reversibility and rather rapidly response in swelling to pH changes. It is expected this IPN hydrogel has potential as controlled drug delivery system or as alternative sorbents for biomedical and environmental use as pH altered.
authors.affiliation: State Key Laboratory of New Textile Materials and Advanced Processing, Wuhan Textile University, Wuhan 430073, China. Electronic address: cuili05@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: Junfang
authors.initials: J
authors.lastname: Jia
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003692:Delayed-Action Preparations; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis*; D039823:Iridoids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009555:Ninhydrin; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D020100:Hydrogels; D039823:Iridoids; D014867:Water; D005780:Gelatin; D048271:Chitosan; C007834:genipin; D009555:Ninhydrin
keywords: Chitosan; Gelatin; Genipin; IPN hydrogels; Swelling