title: Optimization of In - vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches.
abstract: The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surfacet opography of the patches was examined by scanning electron microscopy (SEM). The drug-polymer interaction studies were performed using Fourier transform infrared spectroscopic (FTIR) technique. A correlation between in - vitro drug-release and in - vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. The results of the physicochemical characterization and in - vitro permeation of the prepared patches were promising to formulate transdermal patches with PVP/EC combinations.
authors.affiliation: B . C . Roy College of Pharmacy and Allied Health Sciences , Bidhannagar , Durgapur , 713206, W . B . India .
authors.forename: Pintu
authors.initials: P
authors.lastname: Kumar De
authors.forename: Subrata
authors.initials: S
authors.lastname: Mallick
authors.forename: Biswajit
authors.initials: B
authors.lastname: Mukherjee
authors.forename: Sagar
authors.initials: S
authors.lastname: Sengupta
authors.forename: Satyanarayan
authors.initials: S
authors.lastname: Pattnaik
authors.forename: Subrata
authors.initials: S
authors.lastname: Chakraborty
keywords: FTIR; Ketorolac; Optimization; SEM; Transdermal