title: Optical coherence tomography findings in ocular argyrosis.
abstract: A 68-year-old Caucasian man with a remote history of daily colloidal silver ingestion presented for ophthalmic examination in which he was noted to have a distinct slate gray skin discoloration. Funduscopy revealed confluent perimacular drusenoid deposits bilaterally, most of which localized at the level of or anterior to the inner segment ellipsoid band by optical coherence tomography (OCT) imaging. Enhanced depth imaging OCT demonstrated marked choroidal thinning. Fluorescein angiogram displayed a dark or silent choroid. Confirmatory serum silver levels were found to be markedly elevated. This report describes a unique geographic maculopathy with large drusenoid deposits anterior to the ellipsoid layer and severe choroidal thinning in association with ocular argyrosis.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Rahimy
authors.forename: Robert
authors.initials: R
authors.lastname: Beardsley
authors.forename: Steven
authors.initials: S
authors.lastname: Ferrucci
authors.forename: Pauline
authors.initials: P
authors.lastname: Ilsen
authors.forename: David
authors.initials: D
authors.lastname: Sarraf
mesh_terms: D000368:Aged; D001129:Argyria / Q000097:blood / Q000175:diagnosis*; D015862:Choroid Diseases / Q000097:blood / Q000175:diagnosis*; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D015593:Retinal Drusen / Q000097:blood / Q000175:diagnosis*; D012607:Scotoma / Q000097:blood / Q000175:diagnosis; D018030:Silver Compounds / Q000097:blood / Q000633:toxicity; D041623:Tomography, Optical Coherence
chemical_list: D018030:Silver Compounds