title: Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa.
abstract: Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, Pseudomonas aeruginosa PAO1, Proteus mirabilis and Serratia marcescens, possibly by interfering with their QS systems. The antibiofilm potential of curcumin on uropathogens as well as its efficacy in disturbing the mature biofilms was examined under light microscope and confocal laser scanning microscope. The treatment with curcumin was also found to attenuate the QS-dependent factors, such as exopolysaccharide production, alginate production, swimming and swarming motility of uropathogens. Furthermore, it was documented that curcumin enhanced the susceptibility of a marker strain and uropathogens to conventional antibiotics.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
authors.forename: Issac Abraham Sybiya Vasantha
authors.initials: IA
authors.lastname: Packiavathy
authors.forename: Selvam
authors.initials: S
authors.lastname: Priya
authors.forename: Shunmugiah Karutha
authors.initials: SK
authors.lastname: Pandian
authors.forename: Arumugam Veera
authors.initials: AV
authors.lastname: Ravi
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000302:isolation & purification / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D003474:Curcumin
keywords: Antibiotic resistance; Biofilm; Curcumin; Quorum sensing; Urinary tract infection