title: Carbimazole-associated hypersensitivity vasculitis in a cat.
abstract: Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.
authors.affiliation: Animal Health Trust, Lanwades Park, Newmarket, Suffolk, CB8 7UU.
authors.forename: K
authors.initials: K
authors.lastname: Bowlt
authors.forename: I
authors.initials: I
authors.lastname: Cattin
authors.forename: J
authors.initials: J
authors.lastname: Stewart
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002231:Carbimazole / Q000009:adverse effects* / Q000627:therapeutic use; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002415:Cats; D005260:Female; D006980:Hyperthyroidism / Q000188:drug therapy / Q000662:veterinary*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D013956:Antithyroid Agents; D002231:Carbimazole