title: A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
abstract: BACKGROUND
  Compared with invasive breast cancer, breast cancer in situ (BCIS) is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological profiles of BCIS in Chinese women from 1999-2008.
  
  
  METHODS
  Four thousand and two hundred-eleven female breast cancer (BC) patients were enrolled in this hospital-based nation-wide and multi-center retrospective study. Patients were randomly selected from seven hospitals in seven representative geographical regions of China between 1999 and 2008. The epidemiological, clinical and pathological data were collected based on the designed case report form (CRF).
  
  
  RESULTS
  There were one hundred and forty-three BCIS cases in four thousand and two hundred-eleven BC patients (3.4%). The mean age at diagnosis was 48.3 years and BCIS peaked in age group 40-49 yrs (39.9%). The most common subtype was ductal carcinoma in situ (DCIS) (88.0%). 53.8% were positive for estrogen receptor (ER). Human epidermal growth factor receptor 2 (HER2) positive status was observed in 23.8% of patients. All patients underwent surgeries and 14.7% of them had breast conservation therapies (BCT) (21/143), but 41.9% accepted chemotherapy (64/143). Much less patients underwent radiotherapy (16.0%, 23/143) and among patients who had BCT, 67% accepted radiotherapy (14/21). Endocrine therapy was taken in 44.1% patients (63/143).
  
  
  CONCLUSIONS
  The younger age of BCIS among Chinese women than Western countries and increasing number of cases pose a great challenge. BCT and endocrine therapy are under great needs.
authors.affiliation: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Kong
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Hailin
authors.initials: H
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Lv
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xie
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Jiaoli
authors.initials: J
authors.lastname: Guo
authors.forename: Laisheng
authors.initials: L
authors.lastname: Li
authors.forename: Minqin
authors.initials: M
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Hongjian
authors.initials: H
authors.lastname: Yang
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Tang
authors.forename: Jianjun
authors.initials: J
authors.lastname: He
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Youlin
authors.initials: Y
authors.lastname: Qiao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011159:Population Surveillance; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult