title: HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women.
abstract: HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.
authors.affiliation: Šikl's Department of Pathology, University Hospital, Faculty of Medicine, Charles University, Alej Svobody 80, 304 60, Pilsen, Czech Republic, ondic@medima.cz.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Ondič
authors.forename: Jana
authors.initials: J
authors.lastname: Kašpírková
authors.forename: Ondřej
authors.initials: O
authors.lastname: Májek
authors.forename: Iva
authors.initials: I
authors.lastname: Kinkorová
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000145:classification*; D053918:Papillomavirus Vaccines / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D014611:Vaccination; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000821:virology*
chemical_list: D053918:Papillomavirus Vaccines