title: Access to a new class of biologically active quinoline based 1,2,4-triazoles.
abstract: As an aspect of our ongoing research in search of new antimicrobial armamentarium, a series of 1,2,4-triazol-3-ylthio-acetamides was constructed and in vitro analyzed for their antimicrobial activity against several bacteria and fungi. Aiming to establish an increased potency, the bioassay results were matched to those of 1,3,4-oxadiazoles, utilized previously. Remarkably, 1,2,4-triazoles were found to possess a good spectrum of antifungal potency, which eventually suggested the azole template as an essential pharmacophore to diversify the biological occupations of the attendant molecules. However, it was noticed that the potency of final analogs against each strain placed reliance on the type of substituent present on benzothiazole ring. The structures of final compounds were confirmed with the aid of IR, (1)H NMR, (13)C NMR spectroscopy and CHN analysis.
authors.affiliation: Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul 143 701, South Korea. Electronic address: rahul.svnit11@gmail.com.
authors.forename: Rahul V
authors.initials: RV
authors.lastname: Patel
authors.affiliation: Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul 143 701, South Korea. Electronic address: sewpark@konkuk.ac.kr.
authors.forename: Se Won
authors.initials: SW
authors.lastname: Park
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D011804:Quinolines; D014230:Triazoles; C045575:1,2,4-triazole; C037219:quinoline
keywords: 1,2,4-Triazole; Antimicrobial activity; Benzothiazole; Quinoline; α-Naphthyl isothiocyanate