title: Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animals.
abstract: Radioiodinated cholesteryl iopanoate, a nonhydrolyzable cholesteryl ester probe, showed increased uptake into atherosclerotic aortas of cholesterol-fed rabbits in comparison with normal rabbits. Auto-radiography of the aortas showed the radioactivity to be concentrated in areas of visible atherosclerotic involvement. Lipid extraction and thin-layer chromatography of this tissue as well as liver, adrenal, and plasma confirmed the resistance of this probe to hydrolysis. These findings suggest that (125)I-cholesteryl iopanoate may prove useful for noninvasively monitoring atherosclerosis in intact laboratory animals.
authors.affiliation: Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010.
authors.forename: M R
authors.initials: MR
authors.lastname: De Galan
authors.forename: S W
authors.initials: SW
authors.lastname: Schwendner
authors.forename: J P
authors.initials: JP
authors.lastname: Weichert
authors.forename: R E
authors.initials: RE
authors.lastname: Counsell