title: Factors associated with onset-to-door time in patients with transient ischemic attack admitted to stroke centers.
abstract: OBJECTIVE
  The aim of this study was to elucidate the factors associated with the time from symptom onset to arrival at a stroke center (onset-to-door time [ODT]) in patients with classically defined transient ischemic attack using data from a multicenter, retrospective study.
  
  
  METHODS
  The subjects were patients with transient ischemic attack admitted to 13 stroke centers in Japan within 7 days of onset between 2008 and 2009. A total of 464 patients registered (292 men, 68.5±13.2 years old), and 421 of them (268 men, 68.8±13.1 years old) were included in the analyses. ODT was classified into the following 5 categories: <3 hours, 3 to 6 hours, 7 to 12 hours, 13 to 24 hours, and >24 hours.
  
  
  RESULTS
  There were 233 patients (55.3%) who visited a stroke center within 3 hours of symptom onset. Multiple ordinal logistic regression analysis revealed that motor weakness, speech disturbance, and duration of symptoms >10 minutes were independently associated with a short ODT. Furthermore, a history of transient ischemic attack and hypertension and a referral from another medical facility were independently associated with a long ODT. Patients with a higher ABCD2 score were likely to arrive at a stroke center more quickly.
  
  
  CONCLUSIONS
  We identified several factors that were positively and negatively associated with the ODT in patients with transient ischemic attack.
authors.affiliation: From the Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan (T.U., K.M.); Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan (K.K.); Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan (Y.O.); Department of Neurology, Nagoya Daini Red Cross Hospital, Nagoya, Japan (Y.H.); Department of Neurology and Cerebrovascular Medicine, Saitama Medical University Saitama International Medical Center, Hidaka, Japan (N.T.); Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan (A.S); Department of Neurology, Tokai University, Isehara, Japan (S.T.); Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan (J.N.); Department of Neurology, Ebara Hospital, Tokyo, Japan (K.A.); Department of Neurosurgery, Tokushima University, Tokushima, Japan (S.N.); Department of Neurosurgery, Iwate Medical University, Morioka, Japan (K.O); Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan (T.N., S.U.); Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan (M.M.); and Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Japan (K.I.).
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uehara
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
authors.forename: Akifumi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Takagi
authors.forename: Jyoji
authors.initials: J
authors.lastname: Nakagawara
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Arii
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Nagao
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Koji
authors.initials: K
authors.lastname: Iihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Minematsu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004632:Emergency Medical Services / Q000706:statistics & numerical data*; D005260:Female; D006757:Hospital Units; D006801:Humans; D006973:Hypertension / Q000209:etiology; D002546:Ischemic Attack, Transient / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D012017:Referral and Consultation; D012189:Retrospective Studies; D013064:Speech Disorders / Q000209:etiology; D020521:Stroke / Q000175:diagnosis / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
keywords: ischemic attack, transient; stroke