title: Copper-catalyzed oxidative decarboxylative arylation of benzothiazoles with phenylacetic acids and α-hydroxyphenylacetic acids with O2 as the sole oxidant.
abstract: A Cu(II)-catalyzed oxidative decarboxylative synthesis of 2-aryl benzothiazole from phenylacetic acids and α-hydroxyphenylacetic acids has been developed. This reaction proceeds via Cu(II)-catalyzed decarboxylation, C-H bond oxidation, ring-opening, and condensation steps in a one-pot protocol with dioxygen as the sole terminal oxidant. Various functional groups were tolerated under standard conditions, and isolated yields were as high as 95%.
authors.affiliation: School of Biomedical Sciences at Huaqiao Univeristy , Xiamen, Fujian, 361021, China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.forename: Mingxin
authors.initials: M
authors.lastname: Zhou
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; D016877:Oxidants; D010648:Phenylacetates; D003300:Copper; D010100:Oxygen