title: Management of anticoagulation in the critically ill patient.
abstract: This article presents a review of the most commonly used anticoagulants in the intensive care unit setting. The difference between agents as well as the advantages and disadvantages are reviewed. For each agent, the mechanism of action, dosing, monitoring, adverse effects, and reversal strategies are discussed.
authors.affiliation: Department of Pharmacy, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 377, Houston, TX 77030, USA. Electronic address: khanzelka@mdanderson.org.
authors.forename: Katy M
authors.initials: KM
authors.lastname: Toale
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D016638:Critical Illness; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010875:Pipecolic Acids / Q000008:administration & dosage; D013449:Sulfonamides; D054556:Venous Thromboembolism
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban
keywords: Anticoagulant protocols; Anticoagulation; Bleeding; Direct thrombin inhibitors; Heparin; Low-molecular-weight heparin