title: High-resolution 3D structures reveal the biological functions of reoviruses.
abstract: Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic structures. The results of cryo-EM image reconstructions allow tracing of most of the protein side chains, and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Fang
mesh_terms: D020285:Cryoelectron Microscopy; D021621:Imaging, Three-Dimensional; D012087:Reoviridae / Q000502:physiology* / Q000648:ultrastructure*; D014771:Virion / Q000502:physiology* / Q000648:ultrastructure*; D019065:Virus Assembly; D053586:Virus Internalization