title: Subendocardial ischemia in hypertrophic cardiomyopathy.
abstract: Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience.
authors.affiliation: Department of Cardiology, Matsushita Memorial Hospital, Osaka, Japan. Electronic address: js-k@wf6.so-net.ne.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Department of Cardiology, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugihara
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000188:drug therapy; D003952:Diagnostic Imaging; D004110:Diltiazem / Q000008:administration & dosage; D004452:Echocardiography; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D049268:Positron-Emission Tomography; D011379:Prognosis; D011446:Prospective Studies; D011744:Pyrimidinones; D015899:Tomography, Emission-Computed, Single-Photon; D014700:Verapamil / Q000008:administration & dosage
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C492448:ICG 001; D011744:Pyrimidinones; D014700:Verapamil; D004110:Diltiazem
keywords: Cardiomyopathies; Hypertrophic; Ischemia; Subendocardium