title: Effect of vitamin C on salivary total antioxidant capacity in smokers.
abstract: This study was designed to elucidate the effect of ascorbic acid on salivary total antioxidant capacity in smokers. In this single blind crossover clinical trial, the whole unstimulated saliva of 30 smokers, who were randomly divided into two groups, was collected. In the first phase after the saliva collection, one group of patients took 500 mg of vitamin C powder, for 3 weeks. Then, saliva of all patients was collected. After a one-week wash-out period, vitamin C was given to the other group. The collection of saliva was done after 3 weeks. Total antioxidant capacity was measured. Statistic evaluation was performed by Repeated Measured ANOVA, Independent sample t-test and Covariate test. The mean of total antioxidant capacity with and without using vitamin C was 0.511 ± 0.155 (U/mL) and 0.555 ± 0.171 (U/mL), respectively. This variability was not significant (p = 0.605). Oxidative stress from cigarette smoke was not decreased significantly with using vitamin C.
authors.affiliation: Associate Professor of Oral Medicine Department, Dental School, Shahid Beheshti University Of Medical Sciences, Tehran, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Bakhtiari
authors.forename: Jamileh
authors.initials: J
authors.lastname: Bigom Taheri
authors.forename: Mahin
authors.initials: M
authors.lastname: Bakhshi
authors.forename: Hamed
authors.initials: H
authors.lastname: Mortazavi
authors.forename: Azadeh
authors.initials: A
authors.lastname: Shah Hoseini
authors.forename: Elahe
authors.initials: E
authors.lastname: Vahid Dastjerdi
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Azimi
keywords: Abbreviation; Ascorbic acid; Saliva; Smoking; Total antioxidant capacity; Total antioxidant capacity (TAoC)