title: Functional IL-23R rs10889677 genetic polymorphism and risk of multiple solid tumors: a meta-analysis.
abstract: Interleukin-23 receptor (IL23R) can interact with IL-23 and, thus, is involved in the T-helper 17 (Th17) cell-mediated inflammatory process as well as tumorigenesis. Recently, a functional single nucleotide polymorphism (SNP) rs10889677 has been identified in the 3'-untranslated region of IL-23R. It has been showed that the rs10889677AC SNP could increase the binding affinity of microRNA let-7f and downregulate IL-23R expression. Several case-control studies have examined the association between this SNP and genetic susceptibility of multiple solid tumors. However, the conclusions are conflicting. Therefore, we conducted this meta-analysis to systematically study the role of this functional IL-23R SNP in development of multiple solid tumors. There are a total of 5 studies are eligible (6731 cases and 7296 healthy controls). Either fixed-effect model or random-effect model was used to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Significant association between this functional rs10889677 genetic variant and risk of multiple solid tumors were observed (CC genotype vs. AA genotype: OR = 0.59, 95% CI = 0.53-0.66, P < 0.001). These findings demonstrated that the IL-23R rs10889677 genetic variant might play an important part during malignant transformation of multiple solid tumors.
authors.affiliation: Clinical Laboratory, Cancer Hospital of Shandong Linyi, Shandong Linyi, China.
authors.forename: Shanliang
authors.initials: S
authors.lastname: Zhou
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Ruan
authors.forename: Hongchen
authors.initials: H
authors.lastname: Yu
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Chen
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Yao
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
mesh_terms: D020413:3' Untranslated Regions; D016022:Case-Control Studies; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C515500:IL23R protein, human; D018123:Receptors, Interleukin