title: Effect of a Probiotic Preparation (VSL#3) on CardiovascularRisk Parameters in Critically-Ill Patients.
abstract: BACKGROUND
  Cardiovascular disease (CVD) counts for a major portion of morbidity and mortality globally mostly accompanied by lipid abnormalities. Being at increased risk of cardiac injury, critically ill patients suffer from various lipid disorders. Lipid homeostasis has been efficiently restored by the introduction of probiotics. The aim of this trial was to determine the effect of probiotics on inflammation, antioxidant capacity and lipid peroxidation in critically ill patients.
  
  
  METHODS
  Forty patients admitted to the intensive care unit were randomized to receive placebo or probiotic for 7 days. Serum levels of triglyceride (TG), total cholesterol, HDL-C, LDL-C and high- sensitivity C-reactive protein (hs-CRP) were measured before initiation of the study and on the 7(th) day.
  
  
  RESULTS
  There was a significant difference between two groups regarding the levels of TG, HDL and hs-CRP at the end of the study (P= 0.043, <0.001 and 0.003, respectively); however, there was not a significant difference in total cholesterol and LDL-C levels.
  
  
  CONCLUSIONS
  Administration of probiotics in critically ill patients reduced the levels of TG and hs-CRP and increased HDL-C levels. However, no significant change was detected in levels of total cholesterol or LDL-C.
authors.affiliation: Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sarvin
authors.initials: S
authors.lastname: Sanaie
authors.forename: Mehrangiz
authors.initials: M
authors.lastname: Ebrahimi-Mameghani
authors.forename: Ata
authors.initials: A
authors.lastname: Mahmoodpoor
authors.forename: Kamran
authors.initials: K
authors.lastname: Shadvar
authors.forename: Samad Ej
authors.initials: SE
authors.lastname: Golzari
keywords: Cardiovascular Disease; Critically Ill; Lipid Profile; Probiotic