title: Low grade B cell lymphoma arising in a background of multifocal extra-adrenal myelolipoma.
abstract: Myelolipomas are rare, benign, non-functioning tumors composed of an admixture of mature adipose tissue and hematopoietic elements. Extra-adrenal myelolipomas are extremely rare, but have been reported in multiple sites including the omentum, presacral, and retroperitoneal areas, along with the thorax, kidneys, liver and stomach. We report a case of a 68-year-old man with low-grade B-cell lymphoma arising in a background of recurrent multifocal extra-adrenal myelolipoma. Pathological evaluation of the lesion and bone marrow showed foci of lymphoid aggregate that were confirmed to be monoclonal B lymphoma by flow cytometry. To our knowledge, this is only the third reported case to feature such a rare combination of diseases. The clinical, radiological, and pathological differential diagnostic findings are discussed.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA; phone: 913 588 1180, fax: 913 588 1185, e mail: otawfik@kumc.edu.
authors.forename: Aaron
authors.initials: A
authors.lastname: Noll
authors.forename: Jamie
authors.initials: J
authors.lastname: Boone
authors.forename: Mark
authors.initials: M
authors.lastname: Cunningham
authors.forename: Joshua
authors.initials: J
authors.lastname: Mammen
authors.forename: Ossama
authors.initials: O
authors.lastname: Tawfik
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology*; D008297:Male; D018209:Myelolipoma / Q000150:complications*; D012186:Retroperitoneal Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed