title: An obesity genetic risk score is associated with metabolic syndrome in Chinese children.
abstract: Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/obesity. In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (MetS) in a children population from China. A total of 431 children with MetS and 3046 controls were identified based on the modified ATPIII definition. 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265, FAIM2 rs7138803, NPC1 rs1805081, SEC16B rs10913469, SH2B1 rs4788102, PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479) were genotyped by TaqMan 7900. Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, P=0.016; BDNF rs6265: OR=1.19, 95% CI=1.03-1.39, P=0.021; FAIM2 rs7138803: OR=1.20, 95% CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95% CI=1.04-1.15, P=5.26×10(-4)). After further adjustment for BMI, none of SNPs were associated with risk of MetS (all P>0.05); the association between GRS and risk of MetS remained nominally (OR=1.02, 95%CI=0.96-1.08, P=0.557). However, after correction for multiple testing, only GRS was statistically associated with risk of MetS in the model without adjustment for BMI. The present study demonstrated that there were nominal associations of GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 with risk of MetS. The SNPs in combination have a significant effect on risk of MetS among Chinese children. These associations above were mediated by adiposity.
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Hou
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China. Electronic address: jiemi@vip.163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Mi
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000235:genetics*; D009765:Obesity / Q000150:complications* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
keywords: BCAMS; BMI; CI; Children; Chinese; DBP; FG; FTO; GRS; GWAS; HDL-C; HDL-cholesterol; HWE; Hardy–Weinberg equilibrium; LDL-C; LDL-cholesterol; MetS; Metabolic syndrome; OR; Obesity; Polymorphism; SBP; SNP; TC; TG; body mass index; confidence interval; diastolic blood pressure; fasting glucose; fat mass- and obesity associated; genetic risk score; genome-wide association study; metabolic syndrome; odds ratio; single nucleotide polymorphism; systolic blood pressure; the Beijing Child and Adolescent Metabolic Syndrome; total cholesterol; triglyceride