title: Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy.
abstract: One of the principal biochemical characteristics of malignant cells compared to normal cells is a metabolic switch from oxidative phosphorylation to increased glycolysis, even under hypoxic conditions, and is termed the Warburg effect. Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate and is considered to be a key checkpoint of anaerobic glycolysis. It is elevated in many types of cancers and has been linked to tumor growth, maintenance, and invasion; therefore, its inhibition may restrict the energy supply in tumors and thereby reduce the metastatic and invasive potential of cancer cells. This enzyme is receiving a great deal of attention as a potential diagnostic marker or a predictive biomarker for many types of cancer and as a therapeutic target for new anticancer treatments. In this review, we summarize the role of LDHA in cancer, discuss its potential significance in clinical diagnosis and prognosis of cancer, and propose LDHA as a novel target for the inhibition of tumor growth and invasiveness.
authors.affiliation: Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Miao
authors.forename: Shile
authors.initials: S
authors.lastname: Sheng
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Sun
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D004734:Energy Metabolism; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000502:physiology*; D000080864:Lactate Dehydrogenase 5; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D010085:Oxidative Phosphorylation; D011379:Prognosis; D019289:Pyruvic Acid / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5
keywords: biomarkers; cancer; chemotherapy; diagnosis; glycolysis; lactate dehydrogenase A