title: Medical therapy in adults with congenital heart disease.
abstract: Heart failure is a common late complication in adults with congenital heart defects, both repaired and unrepaired. The onset of clinical heart failure is associated with increased morbidity and mortality. Some patients with congenital heart disease may benefit from medications shown to improve survival in the population with acquired heart failure, but these same therapies may be of no benefit to other patients. Further studies are needed to better guide the choice of medical therapies.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Emory Adult Congenital Heart Center, School of Medicine, Emory University, 1365 Clifton Road Northeast, Suite A2447, Atlanta, GA 30322, USA. Electronic address: wbook@emory.edu.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Book
authors.forename: Robert E
authors.initials: RE
authors.lastname: Shaddy
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D006330:Heart Defects, Congenital / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D054539:Medication Therapy Management / Q000592:standards*; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D017410:Practice Guidelines as Topic
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000451:Mineralocorticoid Receptor Antagonists; D058986:Phosphodiesterase 5 Inhibitors
keywords: Angiotensin-converting enzyme inhibitor; Congenital heart disease; Heart failure; Medical therapy; β-blockers