title: Targeting C-myc G-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths.
abstract: G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.
authors.affiliation: Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA. dparya@clemson.edu.
authors.forename: Nihar
authors.initials: N
authors.lastname: Ranjan
authors.forename: Dev P
authors.initials: DP
authors.lastname: Arya
mesh_terms: D006690:Bisbenzimidazole / Q000737:chemistry*; D054856:G-Quadruplexes; D015394:Molecular Structure; D009355:Neomycin / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D016271:Proto-Oncogene Proteins c-myc; D009355:Neomycin; D006690:Bisbenzimidazole