title: Integrating actin dynamics, mechanotransduction and integrin activation: the multiple functions of actin binding proteins in focal adhesions.
abstract: Focal adhesions are clusters of integrin transmembrane receptors that mechanically couple the extracellular matrix to the actin cytoskeleton during cell migration. Focal adhesions sense and respond to variations in force transmission along a chain of protein-protein interactions linking successively actin filaments, actin binding proteins, integrins and the extracellular matrix to adapt cell-matrix adhesion to the composition and mechanical properties of the extracellular matrix. This review focuses on the molecular mechanisms by which actin binding proteins integrate actin dynamics, mechanotransduction and integrin activation to control force transmission in focal adhesions.
authors.affiliation: Laboratoire d'Enzymologie et Biochimie Structurales CNRS, avenue de la terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Corina
authors.initials: C
authors.lastname: Ciobanasu
authors.forename: Bruno
authors.initials: B
authors.lastname: Faivre
authors.forename: Christophe
authors.initials: C
authors.lastname: Le Clainche
mesh_terms: D000185:Actinin / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D064448:Filamins / Q000378:metabolism; D022001:Focal Adhesions / Q000502:physiology*; D016023:Integrins / Q000737:chemistry / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008840:Microfilament Proteins / Q000378:metabolism*; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016608:Talin / Q000378:metabolism; D000070876:Tensins; D016596:Vinculin / Q000378:metabolism; D000099200:Scaffold Protein ILK
chemical_list: D000185:Actinin; D000199:Actins; D064448:Filamins; D016023:Integrins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D016608:Talin; D000070876:Tensins; D016596:Vinculin; D000099200:Scaffold Protein ILK
keywords: Actin; Focal adhesions; Integrins; Mechanotransduction