title: [Conjunctival squamous cell carcinoma: paradoxical response to interferon eyedrops].
abstract: METHODS
  A 67 year-old male seen for a longstanding corneal-conjunctival tumor.
  
  
  METHODS
  topical interferon α2b (IFN-α2b) 10 U/ml. A significant increase in lesion size was observed after 8 weeks. A surgical excision with cryotherapy was then performed. Pathological examination confirmed the diagnosis of squamous cell carcinoma. At this time the patient was found to have a positive HIV serology.
  
  
  CONCLUSIONS
  Conjunctival intraepithelial neoplasia (CIN) is a pre-cancerous lesion of the ocular surface. Medical treatment of CIN is essentially with IFN-α2b due to its antiviral/antitumor properties. In patients with HIV, treatment response could be paradoxical. We recommend serology for HIV before treatment with topical IFN-α2b.
authors.affiliation: Servicio de Oftalmología, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Mata
authors.affiliation: Servicio de Oftalmología, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España. Electronic address: eduardo_conesa@hotmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Conesa
authors.affiliation: Servicio de Oftalmología, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Castro
authors.affiliation: Servicio de Oftalmología, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España.
authors.forename: L
authors.initials: L
authors.lastname: Martínez
authors.affiliation: Servicio de Oftalmología, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: de Pablo
authors.affiliation: Servicio de Anatomía Patológica, Hospital Central Cruz Roja San José y Santa Adela, Madrid, España.
authors.forename: M L
authors.initials: ML
authors.lastname: González
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D003230:Conjunctival Neoplasms / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins
keywords: Carcinoma escamoso conjuntival; Human Immunodeficiency Virus; Human Papiloma Virus; Interferon Alpha 2b; Interferón Alpha 2b; Neoplasia escamosa de la superficie ocular; Ocular surface squamous neoplasia; Squamous cell carcinoma; Virus de la Inmunodeficiencia Humana; Virus del Papiloma Humano