title: Making birth defects 'preventable': pre-conceptional vitamin supplements and the politics of risk reduction.
abstract: Since the mid-1990s, governments and health organizations around the world have adopted policies designed to increase women's intake of the B-vitamin 'folic acid' before and during the first weeks of pregnancy. Building on initial clinical research in the United Kingdom, folic acid supplementation has been shown to lower the incidence of neural tube defects (NTDs). Recent debate has focused principally on the need for mandatory fortification of grain products with this vitamin. This article takes a longer view, tracing the transformation of folic acid from a routine prenatal supplement to reduce the risk of anaemia to a routine 'pre-conceptional' supplement to 'prevent' birth defects. Understood in the 1950s in relation to social problems of poverty and malnutrition, NTDs were by the end of the century more likely to be attributed to individual failings. This transition was closely associated with a second. Folic acid supplements were initially prescribed to 'high-risk' women who had previously borne a child with a NTD. By the mid-1990s, they were recommended for all women of childbearing age. The acceptance of folic acid as a 'risk-reducing drug' both relied upon and helped to advance the development of preventive and clinical practices concerned with women's health before pregnancy.
authors.affiliation: Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge CB2 3RH, UK. Electronic address: ssa32@cam.ac.uk.
authors.forename: Salim
authors.initials: S
authors.lastname: Al-Gailani
mesh_terms: D000740:Anemia / Q000209:etiology / Q000266:history / Q000517:prevention & control; D019587:Dietary Supplements / Q000266:history*; D005260:Female; D005492:Folic Acid / Q000266:history* / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000209:etiology / Q000266:history* / Q000517:prevention & control; D011057:Politics; D011247:Pregnancy; D011295:Prenatal Care / Q000266:history*; D040242:Risk Reduction Behavior; D006113:United Kingdom; D014803:Vitamin B Complex / Q000266:history* / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid
keywords: Clinical trials; Folic acid; Pre-conception; Public health; Risk; Vitamin supplements