title: Computer-aided diagnosis based on quantitative elastographic features with supersonic shear wave imaging.
abstract: Supersonic shear wave imaging (SSI) has recently been explored as a technique to evaluate tissue elasticity modulus and has become a valuable tool for tumor characterization. The purpose of this study was to develop a novel computer-aided diagnosis (CAD) system that can acquire quantitative elastographic information from color SSI elastography images automatically and objectively for the purpose of classifying benign and malignant breast tumors. Conventional ultrasonography (US) and SSI elastography images of 125 breast tumors (81 benign, 44 malignant), in 93 consecutive patients (mean age: 40 y, age range: 16-75 y), were obtained. After reconstruction of tissue elasticity data and automatic segmentation of each breast tumor, 10 quantitative elastographic features of the tumor and peri-tumoral areas, respectively (elasticity modulus mean, maximum and standard deviation, hardness degree and elasticity ratio), were computed and evaluated. A support vector machine (SVM) classifier was used for optimum classification via combination of these features. The B-mode Breast Imaging Reporting and Data System (BI-RADS) was used to compare gray-scale US and SSI elastography with respect to diagnostic performance. Histopathologic examination was used as the reference standard. Student's t-test, the Mann-Whitney U-test, the point biserial correlation coefficient and receiver operating characteristic curve analysis were performed for statistical analysis. As a result, the accuracy, sensitivity, specificity, positive predictive value and negative predictive value of benign/malignant classification were 95.2% (119/125), 90.9% (40/44), 97.5% (79/81), 95.2% (40/42) and 95.2% (79/83) for the CAD scheme, respectively, and 79.2% (99/125), 90.9% (40/44), 72.8% (59/81), 64.5% (40/62) and 93.7% (59/63) for BI-RADS assessment, respectively. The area under the receiver operating characteristic curve (Az value) for the proposed CAD system using the combination of elastographic features was significantly higher than the Az value for visual assessment by the radiologists using BI-RADS (0.97 vs. 0.91). The results indicate that SSI elastography could be used for computer-aided feature extraction, and the proposed CAD method could improve the diagnostic accuracy of classification of breast tumors to avoid unnecessary biopsy. Furthermore, elastographic features of the peri-tumoral area have the potential to provide critical information in differential diagnosis.
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Medical Ultrasonics, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Medical Ultrasonics, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Qingjing
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Department of Medical Ultrasonics, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Congzhi
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Medical Ultrasonics, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Rongqin
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address: hr.zheng@siat.ac.cn.
authors.forename: Hairong
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006244:Hardness; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D016217:Ultrasonography, Mammary / Q000379:methods*; D055815:Young Adult
keywords: Breast Imaging Reporting and Data System; Breast tumor; Computer-aided diagnosis; Quantitative elastographic features; Supersonic shear wave imaging