title: Cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety.
abstract: The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca(2+) channels.
authors.affiliation: ;
authors.forename: Ramin
authors.initials: R
authors.lastname: Miri
authors.forename: Katayoun
authors.initials: K
authors.lastname: Javidnia
authors.forename: Zahra
authors.initials: Z
authors.lastname: Amirghofran
authors.forename: Seyyed Hossein
authors.initials: SH
authors.lastname: Salimi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sabetghadam
authors.forename: Savis
authors.initials: S
authors.lastname: Meili
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Mehdipour
keywords: 1,4-Dihydropyridines; Cytotoxicity; MTT assay; Nitroimidazole