title: Synthesis of novel compounds as new potent tyrosinase inhibitors.
abstract: In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.76-1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor. All the novel compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR, and elemental analysis.
authors.affiliation: Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran.
authors.forename: Hooshang
authors.initials: H
authors.lastname: Hamidian
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008543:Melanins / Q000096:biosynthesis; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001391:Azo Compounds; D004791:Enzyme Inhibitors; D008543:Melanins; D014442:Monophenol Monooxygenase