title: Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.
abstract: Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.
authors.affiliation: Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil.
authors.forename: Joyce Zalotti
authors.initials: JZ
authors.lastname: Brandt
authors.affiliation: Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil.
authors.forename: Lívia Teresa R
authors.initials: LT
authors.lastname: Silveira
authors.affiliation: Departament of Pathology, School of Medicine - UNESP, Botucatu, SP 18618-970, Brazil.
authors.forename: Tony Fernando
authors.initials: TF
authors.lastname: Grassi
authors.affiliation: Faculty of Dentistry, University of Sao Paulo - FORP/USP, Ribeirão Preto, SP 14040-904, Brazil.
authors.forename: Janete A
authors.initials: JA
authors.lastname: Anselmo-Franci
authors.affiliation: Institute of Biology, University of Campinas - UNICAMP, Campinas, SP 13083-862, Brazil.
authors.forename: Wagner José
authors.initials: WJ
authors.lastname: Fávaro
authors.affiliation: Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil.
authors.forename: Sérgio Luis
authors.initials: SL
authors.lastname: Felisbino
authors.affiliation: Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Barbisan
authors.affiliation: Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil. Electronic address: scarano@ibb.unesp.br.
authors.forename: Wellerson Rodrigo
authors.initials: WR
authors.lastname: Scarano
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity*; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008431:Maternal-Fetal Exchange; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism; D018179:Receptors, Thrombin / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D007211:Indoles; D010636:Phenols; D020011:Protective Agents; D011944:Receptors, Androgen; D018179:Receptors, Thrombin; C016517:indole-3-carbinol; C112908:protease-activated receptor 4; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Chemoprevention; Indole-3-carbinol; Inflammation; Prostate; Reproductive toxicology