title: The spindle assembly checkpoint: progress and persistent puzzles.
abstract: The spindle assembly checkpoint is a conserved mitotic signalling pathway that ensures the equal segregation of chromosomes to daughter cells. Despite intensive work in many model organisms, key features of this safety mechanism remain unexplained. In the present review, I briefly summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway.
authors.affiliation: *Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Hauf
mesh_terms: D020090:Chromosome Segregation; D006801:Humans; D008938:Mitosis; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*