title: Effects of consuming diets containing Agave tequilana dietary fibre and jamaica calyces on body weight gain and redox status in hypercholesterolemic rats.
abstract: Dietary fibre (DF) obtained from Agave tequilana, which is rich in fructans and insoluble DF, and jamaica calyces (Hibiscus sabdariffa), which is rich in DF and phenolic compounds, were assessed as new potential functional ingredients using the hypercholesterolemic animal model. Wistar rats (200-250 g) were divided into 3 groups (n=8) and fed with cholesterol-rich diets supplemented with cellulose (CC, control), agave DF (ADF) or ADF with jamaica calyces (ADF-JC). After consuming the test diets for 5 weeks, weight gain in the ADF-JC group was significantly lower than in the other groups. The ADF and ADF-JC groups had a reduced concentration of cholesterol transporters in the caecum tissue, although no changes were observed in the plasma lipid profile. Both treatments improved the redox status by reducing the malondialdehyde serum levels and protein oxidative damage, compared to the CC group. DF from A. tequilana alone, or in combination with jamaica calyces, shows promising potential as a bioactive ingredient.
authors.affiliation: Instituto Tecnológico de Tepic, Laboratorio Integral de Investigación en Alimentos, Av Instituto Tecnológico No 2595, Col Lagos del Country CP 63175, Tepic, Nayarit, Mexico. Electronic address: sonia.sayago@gmail.com.
authors.forename: Sonia G
authors.initials: SG
authors.lastname: Sáyago-Ayerdi
authors.forename: Raquel
authors.initials: R
authors.lastname: Mateos
authors.forename: Rosa I
authors.initials: RI
authors.lastname: Ortiz-Basurto
authors.forename: Carlota
authors.initials: C
authors.lastname: Largo
authors.forename: José
authors.initials: J
authors.lastname: Serrano
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Granado-Serrano
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sarriá
authors.forename: Laura
authors.initials: L
authors.lastname: Bravo
authors.forename: María
authors.initials: M
authors.lastname: Tabernero
mesh_terms: D027882:Agave / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D004043:Dietary Fiber / Q000378:metabolism*; D031584:Hibiscus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010084:Oxidation-Reduction; D028321:Plant Preparations / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004043:Dietary Fiber; D028321:Plant Preparations
keywords: Agave tequilana; Antioxidants; Dietary fibre; Hibiscus sabdariffa L.; Oxidative stress