title: Effects of 10-GHz microwaves on hematological parameters in Swiss albino mice and their modulation by Prunus avium.
abstract: The objective of this study was to investigate the modulatory role of Prunus avium fruit extract (PAE) on several blood parameters after exposure to 10-GHz microwaves. Swiss albino mice from an inbred colony were selected and divided into 3 groups. Mice in group I served as the control; they were placed in a Plexiglas cage (without energizing the system) for 2 hours/day for 30 consecutive days. Group II mice were exposed to 10-GHz microwaves for 2 hours/day for 30 consecutive days. Mice in group III received PAE (500 mg/kg/body weight) orally once daily 1 hour before exposure to 10-GHz microwaves (2 hours/day) for 30 consecutive days. After 30 days of treatment, blood samples were collected from mice in all groups and analyzed. Hemoglobin, monocytes, packed cell volume, red blood cells, mean corpuscular hemoglobin concentration declined significantly (P ≤ 0.01), whereas white blood cells, lymphocytes, erythrocyte sedimentation rate, and mean corpuscular volume increased significantly (P ≤ 0.01) compared to the control group (group I). Cholesterol, alkaline phosphatase, and lipid peroxidation also increased significantly (P ≤ 0.01). Depletion in blood sugar, total protein, acid phosphatase, and glutathione levels was noted after microwave exposure compared with levels in the sham-exposed (control) mice. Histopathological alterations in blood cells also were seen. Signs of improvements in the hematological, biochemical, and histopathological parameters were recorded in group III, where PAE was supplemented before exposure. Exposure to microwaves influences hematological parameters, which could be ameliorated by the supplementation of PAE.
authors.affiliation: Neurobiology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Sisodia
authors.forename: Faiza
authors.initials: F
authors.lastname: Rifat
authors.forename: Archana
authors.initials: A
authors.lastname: Sharma
authors.forename: Preeti
authors.initials: P
authors.lastname: Srivastava
authors.forename: K
authors.initials: K
authors.lastname: Sharma
mesh_terms: D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D001773:Blood Cells / Q000187:drug effects* / Q000528:radiation effects*; D001799:Blood Sedimentation / Q000187:drug effects / Q000528:radiation effects; D002784:Cholesterol / Q000378:metabolism / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008872:Microwaves / Q000009:adverse effects*; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology*; D027861:Prunus; D011837:Radiation-Protective Agents / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D002784:Cholesterol; D000469:Alkaline Phosphatase; D005978:Glutathione