title: Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders.
abstract: Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders.
authors.affiliation: Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159, Mannheim, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Schaefer
authors.forename: Frank
authors.initials: F
authors.lastname: Enning
authors.forename: Juliane K
authors.initials: JK
authors.lastname: Mueller
authors.forename: J Malte
authors.initials: JM
authors.lastname: Bumb
authors.forename: Cathrin
authors.initials: C
authors.lastname: Rohleder
authors.forename: Thorsten M
authors.initials: TM
authors.lastname: Odorfer
authors.forename: Joachim
authors.initials: J
authors.lastname: Klosterkötter
authors.forename: Martin
authors.initials: M
authors.lastname: Hellmich
authors.forename: Dagmar
authors.initials: D
authors.lastname: Koethe
authors.forename: Christian
authors.initials: C
authors.lastname: Schmahl
authors.forename: Martin
authors.initials: M
authors.lastname: Bohus
authors.forename: F Markus
authors.initials: FM
authors.lastname: Leweke
mesh_terms: D000328:Adult; D000577:Amides; D001095:Arachidonic Acids / Q000097:blood; D001883:Borderline Personality Disorder / Q000097:blood*; D063388:Endocannabinoids / Q000097:blood; D004983:Ethanolamines / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005989:Glycerides / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010169:Palmitic Acids / Q000097:blood; D053284:Polyunsaturated Alkamides / Q000097:blood; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000097:blood*; D055815:Young Adult
chemical_list: D000577:Amides; D001095:Arachidonic Acids; D063388:Endocannabinoids; D004983:Ethanolamines; D005227:Fatty Acids; D005989:Glycerides; D010169:Palmitic Acids; D053284:Polyunsaturated Alkamides; C005958:palmidrol; C094503:glyceryl 2-arachidonate; C078814:anandamide