title: Seminoma presenting as a polypoid bladder mass: a case report.
abstract: We report a case of extragonadal seminoma presenting as a polypoid mass in the urinary bladder. The patient presented with two months history of hematuria. Evaluation by CT scan and cystoscopic examination revealed a polypoid mass in the base of the bladder. Biopsy of the mass revealed a classical type of seminoma. The diagnosis of seminoma was supported by strong immunostaining of the tumor cells for C-Kit and placental alkaline phosphatase. Thorough physical examination and radiologic imaging of other organ systems failed to reveal any other tumor. Both testes were found to be normal on examination and on ultrasound imaging. Patient responded well to chemotherapy. This case is unique because to the best of our knowledge there are no previously reported cases in the literature with seminoma presenting as a bladder mass.
authors.affiliation: Department of Pathology and Laboratory Medicine, King Khalid University Hospital, RIYADH, KINGDOM of SAUDI ARABIA.
authors.forename: Afaf
authors.initials: A
authors.lastname: Alsolamı
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alotaıbı
authors.forename: Shouki
authors.initials: S
authors.lastname: Bazarbashı
authors.forename: Abdulmonem
authors.initials: A
authors.lastname: Almutawa
authors.forename: Mohammed
authors.initials: M
authors.lastname: Akhtar
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003558:Cystoscopy; D058851:GPI-Linked Proteins / Q000032:analysis; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D018239:Seminoma / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D019009:Proto-Oncogene Proteins c-kit; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental