title: [Reduction of radiation exposure during computed tomography perfusion using an iterative reconstruction method].
abstract: The purpose of this study was to evaluate the image noise reduction effect of iterative reconstruction (IR) when used to reduce radiation exposure during computed tomography (CT) perfusion. We scanned a contrast phantom using various radiation doses. Image reconstruction was via filtered back projection (FBP) and IR (adaptive iterative dose reduction 3D: AIDR3D). AIDR3D provided four levels of noise reduction (weak, mild, standard, and strong). We examined the accuracy of CTP map (cerebral blood volume: CBV, mean transist time: MTT, cerebral blood flow: CBF) low-dose IR images to create a digital perfusion phantom that simulates the dynamic curve of ischemic cases using reconstructed images. The optimal filter type of IR was evaluated in the low-frequency area of the NPS at low doses. We were able to obtain the optimal filter type of IR in the low-frequency area of the NPS that was equivalent to that of the reference (150 mA, FBP). The CTP map created using the optimal filter type of IR allowed dose reduction to 80 mA, much lower than the reference. We conclude that it is possible to reduce the dose to 46% of the reference level by using the NPS for dose reduction and IR. IR thus has the potential to contribute to reduction of radiation exposure during CT perfusion.
authors.affiliation: Department of Radiology, Research Institute for Brain and Blood Vessels-Akita.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ohmura
authors.forename: Hideto
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sato
authors.forename: Takato
authors.initials: T
authors.lastname: Ishida
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D059629:Signal-To-Noise Ratio; D014057:Tomography, X-Ray Computed / Q000379:methods*