title: Palladium-catalyzed difunctionalization of enol ethers to amino acetals with aminals and alcohols.
abstract: A new strategy was developed for intercepting the palladium-alkyl species generated in Heck reaction via nucleophilic addition prior to the step of migratory insertion, which leads to a new palladium-catalyzed difunctionalization of enol ethers with aminals and alcohols to afford amino acetals. Mechanistic studies suggested that the cationic cyclometalated Pd(II) complex generated by the oxidative addition of aminal to a Pd(0) species was crucial for this unusual transformation.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, People's Republic of China.
authors.forename: Yinjun
authors.initials: Y
authors.lastname: Xie
authors.forename: Jianhua
authors.initials: J
authors.lastname: Hu
authors.forename: Pan
authors.initials: P
authors.lastname: Xie
authors.forename: Bo
authors.initials: B
authors.lastname: Qian
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000080:Acetals; D000438:Alcohols; D004987:Ethers; D010165:Palladium