title: Dislocation is a developmental mechanism in Dictyostelium and vertebrates.
abstract: The excitable cells of Dictyostelium discoideum show traveling waves of signaling and generate a variety of complex wave forms during their morphogenesis. Important among these wave forms is the 3D spiral or scroll wave, which has been proposed previously to have a twisted variant: the "turbine wave." Herein we argue that a D. discoideum scroll or concentric wave territory containing prespore and prestalk cell types can undergo "dislocation": a wave field that initially controls aggregation of a whole developing population of Dictyostelium cells splits into two. This process leads to discontinuity between two connected domains of wave propagation and to specific phenomena, including high-frequency concentric pacemaker activity by the slime mold's scroll-wave tip. The resulting morphogenetic events reveal a unique mechanism in morphogenesis.
authors.affiliation: Molecular Cell Biology, Sylvius Laboratory, Institute of Biology, University of Leiden, Leiden 2333 BE, The Netherlands.
authors.forename: Antony J
authors.initials: AJ
authors.lastname: Durston
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D004023:Dictyostelium / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D019170:Somites / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*