title: Effect of rhodium (III) complex on experimental carcinogenesis in the livers of rats treated with thioacetamide.
abstract: Enzyme activities and protein content were determined in the cytosolic and mitochondrial fractions of liver homogenates obtained from Rh(III) complex-, thioacetamide- and thioacetamide + Rh(III) complex-treated rats.The Rh(III) complex administered to nonthioacetamide-treated rats produced no significant changes either in the enzymatic activities assayed or in the protein concentration.The Rh(III) complex administered to thioacetamide-treated rats produced significant restoration of the following altered values: cytosolic and mitochondrial aspartate aminotransferase, glutamate dehydrogenase, NADP-isocitrate dehydrogenase, and protein concentration. However, a further increase was produced in the activities of glucose-6-phosphate dehydrogenase and malic enzyme. These increases can be interpreted in terms of an enhancement of the NADPH-dependent detoxifying processes and of nucleic acid synthesis and repair.
authors.affiliation: Instituto de Bioquímica, Centro Mixto (CSIC-UCM), Facultad de Farmacia, Ciudad Universitaria, 28040, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Cascales
authors.forename: D G
authors.initials: DG
authors.lastname: Craciunescu
authors.forename: P
authors.initials: P
authors.lastname: Martín-Sanz
authors.forename: M
authors.initials: M
authors.lastname: Cascales