title: Simultaneous polymerization-induced self-assembly (PISA) and guest molecule encapsulation.
abstract: Nanoparticles with various morphologies such as micelles, worm-like/rod-like and spherical vesicles are made using a polymerization-induced self-assembly (PISA) approach via a one-pot RAFT dispersion polymerization. On polymerization/self-assembly, we report a concurrent highly efficient loading of guest molecules within the nanoparticle structures. Different nanoparticle morphologies, such as spherical micelles, worm-like, rod-like, and spherical vesicles, are achieved by gradually increasing the number-average degree of polymerization (DPn) of the PST block via increasing polymerization times (in a poor solvent) as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. In parallel, a guest molecule (Nile Red) is encapsulated during the polymerization without disturbing the morphology or the polymerization kinetics.
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, University of New South Wales, Sydney NSW, 2052, Australia; Istanbul Technical University Department of Chemistry, Maslak, 34469, Istanbul, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Karagoz
authors.forename: Cyrille
authors.initials: C
authors.lastname: Boyer
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Davis
mesh_terms: D005609:Free Radicals / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D010078:Oxazines / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D008823:Micelles; D010078:Oxazines; D011108:Polymers; C044808:nile red
keywords: dispersion polymerization; encapsulation; living radical polymerization; morphologies; nanoparticles; reversible addition fragmentation chain transfer (RAFT)