title: Imaging pancreatobiliary ductal system with optical coherence tomography: A review.
abstract: An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of the pancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions.
authors.affiliation: Mohammad S Mahmud, Carry Sun, Victor XD Yang, Department of Electrical and Computer Engineering, Biophotonics and Bioengineering Lab, Ryerson University, Toronto, M5B 2K3, Canada.
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Mahmud
authors.forename: Gray R
authors.initials: GR
authors.lastname: May
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Kamal
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Khwaja
authors.forename: Carry
authors.initials: C
authors.lastname: Sun
authors.forename: Alex
authors.initials: A
authors.lastname: Vitkin
authors.forename: Victor Xd
authors.initials: VX
authors.lastname: Yang
keywords: Benign and malignant strictures; Common bile duct; Endoscopy; Main pancreatic duct; Optical coherence tomography; Sphincter of Oddi