title: Role of familiarity versus interleukin-1 genes cluster polymorphisms in chronic periodontitis.
abstract: Periodontitis (PO) is a multifactorial disease affecting about 10% to 20% of the general population. Several studies have suggested that part of the clinical variability in PO might be explained by genetic factors. Among the candidate genes for PO, IL1 gene polymorphisms have been broadly investigated, with variable results, for their relationship with the disease. We studied three IL1 polymorphisms, IL1A C[-889]T (rs1800587), IL1B C[3953/4]T (rs1143634), and IL1RN VNTR [+2018] (rs419598) in relation to different life styles and familiarities. We did not find correlation between these IL1 polymorphisms and chronic PO, as well as between chronic PO and life styles (smoking, alcohol, coffee, fizzy drink and fish). We found a strong correlation, also after adjustment for age, between familiarity and PO onset (P=0.0062; OR 5.754, 95% CI 1.644-20.145). In conclusion, we did confirm the previously suggested association between PO and IL1 gene cluster polymorphisms, and between PO and four common risk factors (coffee, smoking, alcohol and fizzy drinks) and one common protective factor (fish). On the contrary, we found a strong role of familiarity.
authors.affiliation: Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, Italy. Electronic address: daniela.zuccarello@unipd.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zuccarello
authors.affiliation: Department of Neurosciences, Odontostomatology Institute, University of Padova, Padova, Italy.
authors.forename: M Federica
authors.initials: MF
authors.lastname: Bazzato
authors.affiliation: Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ferlin
authors.affiliation: Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pengo
authors.affiliation: Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
authors.forename: Anna Chiara
authors.initials: AC
authors.lastname: Frigo
authors.affiliation: Department of Neurosciences, Odontostomatology Institute, University of Padova, Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Favero
authors.affiliation: Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Foresta
authors.affiliation: Department of Neurosciences, Odontostomatology Institute, University of Padova, Padova, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Stellini
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007375:Interleukin-1
keywords: BMI; Familiarity; Genetics; IL1; IL1A; IL1B; IL1RN; PAG; PO; PO-associated genotype; Periodontitis; body mass index; interleukin 1; interleukin 1 receptor antagonist; periodontitis