title: [Expression of the transcription factors NF-kappaB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis].
abstract: There was studied an expression of transcription factors NF-kappaB p65, NF-kappaB p50 and HIF-1 in the tissue of squamous cell carcinomas of the head and neck. An association of development of regional metastasis of the disease with increased expression of the transcription factor NF-kappaB p50 was revealed. After treatment there were found relapses within 3 to 47 months in 10 patients, regional lymph node metastases in 3 patients, 12 patients died. Metastasis-free survival of patients with squamous cell carcinomas of the head and neck depended on the threshold level of an expression of the transcription factors NF-kappaB p65, p50, HIF-1 equal to 9.6, 7.8 and 9 CU/mg protein respectively.
authors.forename: E L
authors.initials: EL
authors.lastname: Choĭnzonov
authors.forename: L V
authors.initials: LV
authors.lastname: Spirina
authors.forename: I V
authors.initials: IV
authors.lastname: Kondrakova
authors.forename: D A
authors.initials: DA
authors.lastname: Shishkin
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Chizhevskaia
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D013997:Time Factors
chemical_list: D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B