title: Serum ferritin and paraoxonase-1 in canine leishmaniosis.
abstract: Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored for 7 months post-infection, then treated for 3 months with allopurinol, and their response to therapy was followed for 11 additional months. Naturally-infected dogs were staged based on the urine protein/creatinine (UPC) ratio into three groups as follows: group 1 (non-proteinuric; UPC ratio: <0.2), group 2 (borderline proteinuric; UPC ratio: 0.2-0.5) and group 3 (proteinuric; UPC ratio>0.5). An increase in serum ferritin values and a decrease in PON-1 activity were observed 2 months after infection. Both analytes returned to preinfection values following treatment. Significantly higher concentrations of ferritin were observed in dogs classified as either borderline or proteinuric when compared with non-proteinuric dogs whereas serum PON-1 activity was decreased only in proteinuric dogs.
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Martinez-Subiela
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain. Electronic address: jjceron@um.es.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cerón
authors.affiliation: School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Strauss-Ayali
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: J D
authors.initials: JD
authors.lastname: Garcia-Martinez
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Tecles
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.affiliation: San Marco Veterinary Hospital, Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Caldin
authors.affiliation: School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Baneth
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy / Q000469:parasitology* / Q000652:urine; D004285:Dogs; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D005293:Ferritins / Q000097:blood*; D018314:Leishmania infantum / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology / Q000652:urine / Q000662:veterinary*; D008297:Male; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D004791:Enzyme Inhibitors; D000493:Allopurinol; D002097:C-Reactive Protein; D005293:Ferritins; D003404:Creatinine; D043303:Aryldialkylphosphatase
keywords: Dog; Ferritin; Leishmaniosis; Paraoxonase-1