title: Functional roles of benzothiazole motif in antiepileptic drug research.
abstract: Benzothiazoles are promising candidates for the design of novel antiepileptic drugs. The endocyclic sulphur and nitrogen functions present in this heterocyclic nucleus have been shown to be critical for the anticonvulsant activity. The present review outlines the rational design and anticonvulsant potential of promising benzothiazole lead molecules. Particular focus has been placed on the structure activity relationship of different benzothiazole derivatives giving selected examples of molecules with significant activity being that these molecules may serve as prototypes for the development of more active antiepileptic drugs.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Amir
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110 062, India. mamir_s2003@yahoo.co.in.
authors.forename: Mohd Zaheen
authors.initials: MZ
authors.lastname: Hassan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000627:therapeutic use; D052160:Benzothiazoles / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D004597:Electroshock; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000627:therapeutic use; D015221:Potassium Channels / Q000819:agonists / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D052160:Benzothiazoles; D018696:Neuroprotective Agents; D015221:Potassium Channels; C005465:benzothiazole