title: Effects of cognitive psychotherapy on the biological rhythm of patients with depression.
abstract: BACKGROUND
  Stability between internal and external biological regulators are essential to stable mood states. However, the literature needs studies investigating the effect of brief psychotherapies in the biological rhythm regularization.
  
  
  OBJECTIVE
  To verify the capacity regulation of biological rhythms in two models of brief psychotherapy for the remission of depressive symptoms.
  
  
  METHODS
  We conducted a randomized clinical trial with young adults aged 18-29 years old who met diagnostic criteria for depression according to the Structured Clinical Interview for DSM (SCID). In order to evaluate the biological rhythm the Biological Rhythm of assessment in Neuropsychiatry (BRIAN) interview was used; whereas the severity of depression was assessed by the Hamilton Depression Rating Scale (HDRS). The psychotherapy models consisted of two cognitive psychotherapies: Cognitive Narrative Therapy (CNT) and Cognitive-Behavioral Therapy (CBT).
  
  
  RESULTS
  The sample consisted of 97 randomized into two models of brief psychotherapy. The patients regulated the biological rhythm from baseline to post-intervention (p=.001) and follow up (p=.003). We also found a positive moderate correlation between biological rhythm regularization and remission of the depressive symptoms (r=.594; p<.001).
  
  
  CONCLUSIONS
  The two models of brief psychotherapies were effective in the remission of depressive symptoms as well as the regulation of biological rhythms in the follow-up of 6 months.
  
  
  CONCLUSIONS
  We did not assess genetic, hormonal and neurochemical factors. Also, we did not include patients in pharmaceutical treatment, and with severe symptomatology.
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
authors.forename: Thaíse Campos
authors.initials: TC
authors.lastname: Mondin
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
authors.forename: Taiane
authors.initials: T
authors.lastname: de Azevedo Cardoso
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
authors.forename: Karen
authors.initials: K
authors.lastname: Jansen
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Coiro Spessato
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
authors.forename: Luciano Dias
authors.initials: LD
authors.lastname: de Mattos Souza
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil. Electronic address: ricardo.as@uol.com.br.
authors.forename: Ricardo Azevedo
authors.initials: RA
authors.lastname: da Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000503:physiopathology / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008960:Models, Psychological; D011569:Psychiatric Status Rating Scales; D011614:Psychotherapy, Brief; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
keywords: Biological rhythm; Cognitive Behavior Therapy; Cognitive Narrative Therapy; Depression; Treatment effectiveness