title: Host genetic variants in obesity-related nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a complex disease. The considerable variability in the natural history of the disease suggests an important role for genetic variants in the disease development and progression. There is evidence based on genome-wide association studies and/or candidate gene studies that genetic polymorphisms underlying insulin signaling, lipid metabolism, oxidative stress, fibrogenesis, and inflammation can predispose individuals to NAFLD. This review highlights some of the genetic variants in NAFLD.
authors.affiliation: Betty and Guy Beatty Center for Integrated Research, Center for Liver Disease, Inova Health System, Claude Moore Building, 3300 Gallows Road, Falls Church, VA 22042, USA.
authors.forename: Rohini
authors.initials: R
authors.lastname: Mehta
authors.forename: Aybike
authors.initials: A
authors.lastname: Birerdinc
authors.forename: Zobair M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D050156:Adipogenesis / Q000235:genetics; D053305:Apolipoprotein C-III / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D005234:Fatty Liver / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D056726:Genetic Association Studies; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008049:Lipase / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D008099:Liver / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D010711:Phosphatidate Phosphatase / Q000235:genetics; D050918:Phosphatidylethanolamine N-Methyltransferase / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011943:Receptors, Adrenergic, beta / Q000235:genetics; D014280:Triglycerides / Q000378:metabolism; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D053305:Apolipoprotein C-III; D002352:Carrier Proteins; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008049:Lipase; D008565:Membrane Proteins; D047492:Peroxisome Proliferator-Activated Receptors; D010711:Phosphatidate Phosphatase; D050918:Phosphatidylethanolamine N-Methyltransferase; D011943:Receptors, Adrenergic, beta; D014280:Triglycerides; C103673:HFE protein, human; C106092:microsomal triglyceride transfer protein; C494489:PEMT protein, human; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent; C485999:LPIN1 protein, human
keywords: GWAS; Polymorphism; SNP; Steatosis