title: Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis.
abstract: Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.
authors.affiliation: Department of Pathophysiology and Transplantation "Dino Ferrari" Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Fenoglio
authors.forename: Elisa
authors.initials: E
authors.lastname: Ridolfi
authors.forename: Claudia
authors.initials: C
authors.lastname: Cantoni
authors.forename: Milena
authors.initials: M
authors.lastname: De Riz
authors.forename: Rossana
authors.initials: R
authors.lastname: Bonsi
authors.forename: Maria
authors.initials: M
authors.lastname: Serpente
authors.forename: Chiara
authors.initials: C
authors.lastname: Villa
authors.forename: Anna M
authors.initials: AM
authors.lastname: Pietroboni
authors.forename: Robert T
authors.initials: RT
authors.lastname: Naismith
authors.forename: Enrique
authors.initials: E
authors.lastname: Alvarez
authors.forename: Becky J
authors.initials: BJ
authors.lastname: Parks
authors.forename: Nereo
authors.initials: N
authors.lastname: Bresolin
authors.forename: Anne H
authors.initials: AH
authors.lastname: Cross
authors.forename: Laura M
authors.initials: LM
authors.lastname: Piccio
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004185:Disability Evaluation; D015536:Down-Regulation; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D011237:Predictive Value of Tests
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs; C505361:MIRN15 microRNA, human; C525067:MIR223, human; C552430:MIRN23a microRNA, human
keywords: Multiple sclerosis; biomarkers; demyelination; microRNA; serum