title: Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia.
abstract: This study tested the hypothesis that being overweight/obese at diagnosis of childhood ALL was related to risk of relapse. In a national cohort of 1033 patients from the UK, there was no evidence that weight status at diagnosis was related significantly to risk of relapse: log-rank test (P=0.90) with overweight and obesity as the exposure (n=917); individual (P=0.42) and stepwise (P=0.96) proportional hazards models, with BMI Z score as the exposure. The study does not support the hypothesis that being overweight/obese at diagnosis impairs prognosis in childhood ALL in the UK.
authors.affiliation: *College of Medical, Veterinary and Life Sciences, Queen Mother's Hospital †School of Mathematics and Statistics, University of Glasgow ‡School of Psychological Sciences & Health, University of Strathclyde, Glasgow, Scotland.
authors.forename: Fahad K
authors.initials: FK
authors.lastname: Aldhafiri
authors.forename: John H
authors.initials: JH
authors.lastname: McColl
authors.forename: John J
authors.initials: JJ
authors.lastname: Reilly
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000209:etiology; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis; D011379:Prognosis; D012307:Risk Factors