title: A case of cutaneous polyarteritis nodosa with elevated serum interleukin-6 levels complicated by leg arterial stenosis and destructive arthropathy of the left ankle.
abstract: We report a case of a 60-year-old female with cutaneous polyarteritis nodosa (CPN) of the left ankle, accompanied by elevated serum interleukin (IL)-6 levels. Computed tomographic angiography revealed severe narrowing of medium-sized arteries in her left leg. Destructive arthropathy in the left ankle was identified by X-ray and magnetic resonance imaging. This is the first Japanese case of severe CPN complicated by destructive arthropathy. Quantification of serum IL-6 might be useful in diagnosis and evaluation of CPN.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences , 1-7-1 Sakamoto, Nagasaki 852-8501 , Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Ayuko
authors.initials: A
authors.lastname: Tokuyama
authors.forename: Remi
authors.initials: R
authors.lastname: Sumiyoshi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Akitomo
authors.initials: A
authors.lastname: Okada
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Kawashiri
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Miyashita
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000842:Ankle / Q000000981:diagnostic imaging* / Q000473:pathology; D000843:Ankle Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D003251:Constriction, Pathologic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007866:Leg / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012867:Skin / Q000473:pathology*
chemical_list: D015850:Interleukin-6