title: Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.
abstract: HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure-activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed.
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Famiglini
authors.forename: Antonio
authors.initials: A
authors.lastname: Coluccia
authors.forename: Andrea
authors.initials: A
authors.lastname: Brancale
authors.forename: Sveva
authors.initials: S
authors.lastname: Pelliccia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: La Regina
authors.forename: Romano
authors.initials: R
authors.lastname: Silvestri
mesh_terms: D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D013450:Sulfones; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase