title: PVA bio-nanocomposites: a new take-off using cellulose nanocrystals and PLGA nanoparticles.
abstract: The formation of a new generation of hybrid bio-nanocomposites is reported: these are intended at modulating the mechanical, thermal and biocompatibility properties of the poly(vinyl alcohol) (PVA) by the combination of cellulose nanocrystals (CNC) and poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with bovine serum albumin fluorescein isothiocynate conjugate (FITC-BSA). CNC were synthesized from microcrystalline cellulose by hydrolysis, while PLGA nanoparticles were produced by a double emulsion with subsequent solvent evaporation. Firstly, binary bio-nanocomposites with different CNC amounts were developed in order to select the right content of CNC. Next, ternary PVA/CNC/NPs bio-nanocomposites were developed. The addition of CNC increased the elongation properties without compromising the other mechanical responses. Thermal analysis underlined the nucleation effect of the synergic presence of cellulose and nanoparticles. Remarkably, bio-nanocomposite films are suitable to vehiculate biopolymeric nanoparticles to adult bone marrow mesenchymal stem cells successfully, thus representing a new tool for drug delivery strategies.
authors.affiliation: Institute of Polymer Science and Technology, ICTP - CSIC, Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Rescignano
authors.forename: E
authors.initials: E
authors.lastname: Fortunati
authors.forename: S
authors.initials: S
authors.lastname: Montesano
authors.forename: C
authors.initials: C
authors.lastname: Emiliani
authors.forename: J M
authors.initials: JM
authors.lastname: Kenny
authors.forename: S
authors.initials: S
authors.lastname: Martino
authors.forename: I
authors.initials: I
authors.lastname: Armentano
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D004339:Drug Compounding; D055119:Elastic Modulus; D004705:Endocytosis; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
chemical_list: D004337:Drug Carriers; C039217:fluorescein isothiocyanate bovine serum albumin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; D011142:Polyvinyl Alcohol; D002482:Cellulose; D016650:Fluorescein-5-isothiocyanate; C109691:microcrystalline cellulose
keywords: Bio-nanocomposite; Cellulose nanocrystals; Poly(vinyl alcohol); Stem cells