title: Isolated adrenocorticotropic hormone deficiency due to probable lymphocytic hypophysitis in a woman.
abstract: We report a 22-year-old woman who presented with asthenia, weight loss and hypotension in which extensive pituitary and adrenal investigations were diagnostic of isolated adrenocorticotropic hormone deficiency (IAD) of pituitary origin. Magnetic resonance imaging of the hypothalamus and pituitary showed a normal-sized pituitary, with no mass lesion. The diagnosis of IAD probably secondary to lymphocytic hypophysitis (LYH) was made. IAD is able to be the way of presentation of LYH, although the disease could or could not turn into a panhypopituitarism. Prompt recognition of this potentially fatal condition is important because of the availability of effective treatment. Indeed, regular endocrine and imaging follow up is important for patients with IAD and normal initial pituitary imaging results to detect early new-onset pituitary hormones deficiencies or imaging abnormalities.
authors.affiliation: Department of Endocrinology, HediChaker Hospital, 3029 Sfax, Tunisia.
authors.forename: Faten Hadj
authors.initials: FH
authors.lastname: Kacem
authors.forename: Nadia
authors.initials: N
authors.lastname: Charfi
authors.forename: Mouna Feki
authors.initials: MF
authors.lastname: Mnif
authors.forename: Mahdi
authors.initials: M
authors.lastname: Kamoun
authors.forename: Faouzi
authors.initials: F
authors.lastname: Akid
authors.forename: Fatma
authors.initials: F
authors.lastname: Mnif
authors.forename: Basma Ben
authors.initials: BB
authors.lastname: Naceur
authors.forename: Nabila
authors.initials: N
authors.lastname: Rekik
authors.forename: Zainab
authors.initials: Z
authors.lastname: Mnif
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abid
keywords: Autoimmunity; isolatedadrenocorticotropichormonedeficiency; lymphocytichypophysitis