title: Inhibitory effects of Juglans mandshurica leaf on allergic dermatitis-like skin lesions-induced by 2,4-dinitrochlorobenzene in mice.
abstract: Allergic dermatitis among common skin diseases is a chronic and recurrent inflammatory skin disorder caused by genetic, environmental, allergens as well as microbial factors. Allergic dermatitis patients clinically present skin erythematous plaques, eruption, elevated serum immunoglobulin E (IgE) and T helper cell type 2 (Th2) cytokine levels. The leaf of walnut tree Juglans mandshurica Maxim (JM) is consumed food and traditional phytomedicine in Asia, China, Siberia and Korea. JM has been reported to have various pharmacological activities, such as anti-tumor, anti-oxidative, and anti-bacterial effects. However, no study of the inhibitory effects of JM on allergic dermatitis has been reported. Here, we demonstrated the effect of JM against 2,4-dinitrochlorobenzene-induced allergic dermatitis-like skin lesions. 0.5% JM or 1% dexamethasone (positive control) applied to the dorsal skin inhibited development of allergic dermatitis-like skin lesions and scratching behavior. Moreover, the Th2-mediated inflammatory cytokines IgE, tumor necrosis factor-α, interleukin (IL)-1, and IL-13, were significantly reduced by JM treatment. Thus JM can inhibit development of allergic dermatitis-like skin lesions in mice by regulating immune mediators, and may be an effective alternative therapy for allergic dermatitis.
authors.affiliation: Department of Life and Nanopharmaceutical Science, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors.forename: Gunhyuk
authors.initials: G
authors.lastname: Park
authors.affiliation: Department of Life and Nanopharmaceutical Science, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea. Electronic address: msohok@khu.ac.kr.
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Oh
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D016207:Cytokines / Q000097:blood / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D004137:Dinitrochlorobenzene / Q000494:pharmacology*; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D031324:Juglans / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D001713:Biphenyl Compounds; D016207:Cytokines; D004137:Dinitrochlorobenzene; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D007073:Immunoglobulin E; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: 2,4-Dinitrochlorobenzene; Allergic dermatitis-like skin; Immunoglobulin E; Juglans mandshurica leaf; Scratching behavior