title: A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.
abstract: A case study is reported whereby an individual with known sulfite and sulfonamide allergies develops hypersensitivity to taurine above a threshold level as well as to the non-nutritive sweetener acesulfame potassium, compounds that are not normally associated with allergic reactions. Sulfites, sulfonamides, taurine and acesulfame potassium all contain a SO3 moiety. Challenge tests provide evidence for the hypersensitivities to taurine and acesulfame potassium. The subject is also allergic to thiuram mix and thimerosal, sulfur containing compounds, as well as to various food products. This may be the first case where hypersensitivities to taurine and acesulfame potassium have been documented and reported. Several mechanistic explanations are provided for the untoward reactions to taurine and acesulfame potassium.
authors.affiliation: Creighton University Medical Center, Omaha, NE 68178, USA. Electronic address: sid.stohs9@gmail.com.
authors.forename: Sidney J
authors.initials: SJ
authors.lastname: Stohs
authors.affiliation: Research and Development, AdvoCare International, Plano, TX 74074, USA.
authors.forename: Mark J S
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D013447:Sulfites / Q000009:adverse effects / Q000737:chemistry; D013449:Sulfonamides / Q000009:adverse effects / Q000737:chemistry; D013455:Sulfur / Q000009:adverse effects*; D013654:Taurine / Q000009:adverse effects / Q000737:chemistry; D013843:Thiazines / Q000009:adverse effects / Q000737:chemistry
chemical_list: D013447:Sulfites; D013449:Sulfonamides; D013843:Thiazines; D013654:Taurine; D013455:Sulfur; C006362:acetosulfame
keywords: Acesulfame potassium; Allergy; Disulfiram; Sulfite; Taurine