title: Lung cancer screening with low-dose computed tomography.
abstract: Current guidelines endorse low-dose computed tomography (LDCT) screening for smokers and former smokers aged 55 to 74, with at least a 30-pack-year smoking history. Adherence to published algorithms for nodule follow-up is strongly encouraged. Future directions for screening research include risk stratification for selection of the screening population and improvements in the diagnostic follow-up for indeterminate pulmonary nodules. Screening for lung cancer with LDCT has revealed that there are indolent lung cancers that may not be fatal. More research is necessary if the risk-benefit ratio in lung cancer screening is to be maximized.
authors.affiliation: Department of Radiology, Wake Forest University Health Sciences Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA. Electronic address: cchiles@wakehealth.edu.
authors.forename: Caroline
authors.initials: C
authors.lastname: Chiles
mesh_terms: D000368:Aged; D055088:Early Detection of Cancer / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011829:Radiation Dosage; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed / Q000009:adverse effects / Q000191:economics / Q000379:methods*
keywords: Computed tomography; Lung cancer; Lung cancer screening; Pulmonary nodule; Thoracic imaging