title: Simultaneous detection of mercury(II) and silver(I) ions with picomolar sensitivity.
abstract: We develop a new method for the simultaneous detection of Hg(2+) and Ag(+) by integrating bifunctional strand displacement amplification and multiplexed short linear quencher-fluorophore probes. This method exhibits excellent specificity and high picomolar sensitivity, which is improved by up to 4 orders of magnitude compared to the current approaches for metal ion assay.
authors.affiliation: Single-Molecule Detection and Imaging Laboratory, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. zhangcy@siat.ac.cn.
authors.forename: Guichi
authors.initials: G
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Chun-yang
authors.initials: CY
authors.lastname: Zhang
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D054856:G-Quadruplexes; D006427:Hemin / Q000737:chemistry / Q000378:metabolism; D007477:Ions / Q000737:chemistry*; D008628:Mercury / Q000032:analysis*; D012834:Silver / Q000032:analysis*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D012834:Silver; D006427:Hemin; D008628:Mercury