title: Effects of vibration in forced posture on biochemical bone metabolism indices, and morphometric and mechanical properties of the lumbar vertebra.
abstract: Epidemiological studies have shown a relatively strong association between occupational lower back pain (LBP) and long-term exposure to vibration. However, there is limited knowledge of the impact of vibration and sedentariness on bone metabolism of the lumbar vertebra and the mechanism of bone-derived LBP. The aim of this study was to investigate the effects of vibration in forced posture (a seated posture) on biochemical bone metabolism indices, and morphometric and mechanical properties of the lumbar vertebra, and provide a scientific theoretical basis for the mechanism of bone-derived LBP, serum levels of Ca(2+), (HPO4)(2-), tartrate-resistant acid phosphatase (TRAP), bone-specific alkaline phosphatase (BALP), and bone gla protein (BGP),the pathological changes and biomechanics of lumbar vertebra of New Zealand white rabbits were studied. The results demonstrate that both forced posture and vibration can cause pathological changes to the lumbar vertebra, which can result in bone-derived LBP, and vibration combined with a seated posture could cause further damage to bone metabolism. Serological changes can be used as early markers for clinical diagnosis of bone-derived LBP.
authors.affiliation: Institute of Military Training Related Medical Science, The 150th Hospital of PLA, Luoyang, Henan, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chang
authors.forename: Fuling
authors.initials: F
authors.lastname: Wei
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ju
authors.forename: Lvgang
authors.initials: L
authors.lastname: Zhu
authors.forename: Changlin
authors.initials: C
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Xincheng
authors.initials: X
authors.lastname: Zuo
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gao
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001696:Biomechanical Phenomena; D002118:Calcium / Q000097:blood; D005260:Female; D007527:Isoenzymes / Q000097:blood; D017116:Low Back Pain / Q000209:etiology; D008159:Lumbar Vertebrae / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D015675:Osteocalcin / Q000097:blood; D010756:Phosphoric Acids / Q000097:blood; D011187:Posture; D011817:Rabbits; D012149:Restraint, Physical; D000071681:Tartrate-Resistant Acid Phosphatase; D014732:Vibration / Q000009:adverse effects*
chemical_list: D007527:Isoenzymes; D010756:Phosphoric Acids; D015675:Osteocalcin; C030242:phosphoric acid; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D002118:Calcium