title: One-pot three-component approach to the synthesis of polyfunctional pyrazoles.
abstract: A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.
authors.affiliation: Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University , Hangzhou 310058, P. R. China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
authors.forename: Hangcheng
authors.initials: H
authors.lastname: Ni
authors.forename: Wenteng
authors.initials: W
authors.lastname: Chen
authors.forename: Jiaan
authors.initials: J
authors.lastname: Shao
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.forename: Binhui
authors.initials: B
authors.lastname: Chen
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D006834:Hydrazines; D011720:Pyrazoles