title: Pulmonary hypertension associated with chronic hemolytic anemia and other blood disorders.
abstract: Pulmonary hypertension (PH) has emerged as a major complication of several hematologic disorders, including hemoglobinopathies, red cell membrane disorders, chronic myeloproliferative disorders, and splenectomy. With the exception of sickle cell disease, there are a limited number of studies systematically evaluating the prevalence of PH using the gold standard right heart catheterization in these disorders. The cause of the PH in patients with hematologic disorders is multifactorial, and a thorough diagnostic evaluation is essential. More importantly, there are virtually no high-quality data on the safety and efficacy of PH-targeted therapy in this patient population.
authors.affiliation: Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, Department of Medicine, Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, M/C 719, Chicago, IL 60612, USA. Electronic address: machador@uic.edu.
authors.forename: Roberto F
authors.initials: RF
authors.lastname: Machado
authors.forename: Harrison W
authors.initials: HW
authors.lastname: Farber
mesh_terms: D000743:Anemia, Hemolytic / Q000150:complications*; D000755:Anemia, Sickle Cell / Q000150:complications; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D013156:Splenectomy / Q000009:adverse effects
keywords: Myeloproliferative disorders; Pulmonary hypertension; Sickle cell disease; Splenectomy; Thalassemia