title: Negative pressure wound therapy with saline instillation: 131 patient case series.
abstract: Negative pressure wound therapy combined with timed, cyclical instillation (NPWTi) of topical wound solutions has been recently presented as a new adjunctive modality for treating wounds with signs of infection. Normal saline, antiseptics and antimicrobials all have been proposed in scientific and clinical studies as potentially effective when used with NPWTi for treating heavily infected wounds. This is a prospective clinical study of 131 patients with 131 wounds treated with NPWTi using saline between January 2012 and December 2012 in two orthopaedic centres and one surgical wound healing centre in France. Saline was exclusively used. Results were favourable: in 98% of the cases, the wounds could be closed after debridement and following the use of NPWTi. Mean duration of NPWTi was 12·19 days. This does not preclude the need for treating the biofilm appropriately with more active antibacterial products when biofilm has been documented.
authors.affiliation: Orthopedic Department, Strasbourg University Hospital, Strasbourg, France.
authors.forename: David
authors.initials: D
authors.lastname: Brinkert
authors.forename: Mazen
authors.initials: M
authors.lastname: Ali
authors.forename: Magali
authors.initials: M
authors.lastname: Naud
authors.forename: Nicolas
authors.initials: N
authors.lastname: Maire
authors.forename: Chloé
authors.initials: C
authors.lastname: Trial
authors.forename: Luc
authors.initials: L
authors.lastname: Téot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000628:therapy; D005260:Female; D005597:Fractures, Open / Q000150:complications / Q000628:therapy; D006097:Granulation Tissue; D006406:Hematoma / Q000150:complications / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D009779:Occlusive Dressings; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*; D013529:Surgical Wound Dehiscence / Q000150:complications / Q000628:therapy; D007507:Therapeutic Irrigation; D014456:Ulcer / Q000150:complications / Q000628:therapy; D014945:Wound Healing; D014946:Wound Infection / Q000628:therapy; D014947:Wounds and Injuries / Q000209:etiology / Q000628:therapy*; D055815:Young Adult
chemical_list: D012965:Sodium Chloride
keywords: Diabetic foot ulcers; Infection; Instillation therapy; Orthopaedic wounds