title: Characteristics and outcomes of acute otitis media in children carrying streptococcus pneumoniae or haemophilus influenzae in their nasopharynx as a single otopathogen after introduction of the heptavalent pneumococcal conjugate vaccine.
abstract: After PCV7 implementation, clinical characteristics were investigated in 832 young children with acute otitis media, carrying a single S. pneumoniae or H. influenzae in their nasopharynx. As compared with H. influenzae, S. pneumoniae-associated acute otitis media was less frequently associated with treatment failure (odds ratio = 0.5; 95% confidence interval: 0.36-0.83) and recurrence (odds ratio = 0.4; 95% confidence interval: 0.22-0.75). Post-PCV7 serotype replacement seemed not to affect the acute otitis media characteristics in these children.
authors.affiliation: From the *Clinical Research Centre (CRC), Centre Hospitalier Intercommunal Créteil, France; †Service de Médecine néonatale, Centre Hospitalier Intercommunal Créteil, France; ‡National Reference Center for Pneumococci, AP-HP, Hôpital Européen Georges Pompidou, Université Paris 5, Paris; §Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), Saint Maur des Fossés; ¶Association Française de Pédiatrie Ambulatoire, Gradignan; and ‖Service de Microbiologie, Hôpital Robert-Debré (AP-HP), Université Paris-Diderot, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Caeymaex
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Varon
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Stéphane
authors.initials: S
authors.lastname: Béchet
authors.forename: Véronique
authors.initials: V
authors.lastname: Derkx
authors.forename: Véronique
authors.initials: V
authors.lastname: Desvignes
authors.forename: Catherine
authors.initials: C
authors.lastname: Doit
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
mesh_terms: D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D006193:Haemophilus influenzae; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D012008:Recurrence; D013296:Streptococcus pneumoniae; D016896:Treatment Outcome
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines