title: IL2RA Allele Increases Risk of Neuromyelitis Optica in Southern Han Chinese.
abstract: BACKGROUND
  Neuromyelitis optica (NMO) and multiple sclerosis (MS) are chronic neuro-inflammatory diseases believed to arise from complex interactions between environmental and genetic factors. Recently, single nucleotide polymorphisms (SNPs) in interleukin (IL)-2 and -7 receptor alpha genes have been identified as novel susceptibility alleles for MS in genome-wide association studies. However, similar research on NMO is limited. We aimed to investigate the association of IL2RA SNPs rs2104286 and rs12722489 and IL7RA SNP rs6897932 with Southern Han Chinese NMO and MS patients.
  
  
  METHODS
  Frequencies of the three SNPs were examined in Southern Han Chinese mS cases (n=78), NMS cases (n=67) and controls (n=133) using sequencing-based typing.
  
  
  RESULTS
  The rs2104286(G) frequency in the IL2RA gene was significantly higher in NMO patients than in controls (p(uncorr)=0.013, p(corr)=0.026, OR:1.942, 95%CI:1.146-3.291).
  
  
  CONCLUSIONS
  The rs2104286 G allele in IL2RA is present at higher frequencies in NMO patients than in healthy controls within a Southern Han Chinese population.
  
  
  
  Les allèles IL2RA augmentent le risque de neuromyélite optique chez les Chinois Han du sud.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Dai
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Zhong
authors.forename: Yuge
authors.initials: Y
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.forename: Aimin
authors.initials: A
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Bao
authors.forename: Fuhua
authors.initials: F
authors.lastname: Peng
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics; D009471:Neuromyelitis Optica / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit