title: Acute focal bacterial nephritis due to methicillin-resistant Staphylococcus aureus in an immunocompetent adult.
abstract: Acute focal bacterial nephritis (AFBN) is a rare, acute focal infection of the renal parenchyma without liquefaction. The pathogenesis is thought to be due to hematogenous infection or ascending infection from the lower urinary tract. Escherichia coli has been the major pathogen isolated in prior cases, but other Gram-negative enteric pathogens and Staphylococcus aureus have been reported as well. It is well described in children and adults with diabetes and organ transplantation, but has not been previously reported in healthy adults. We report a case of an immunocompetent adult female who presented with a methicillin-resistant Staphylococcus aureus bacteremia after a skin and soft tissue infection that resulted in AFBN.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Naval Medical Center, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA, AdamsN@state.gov.
authors.forename: N
authors.initials: N
authors.lastname: Adams
authors.forename: M D
authors.initials: MD
authors.lastname: Johnson
authors.forename: D W
authors.initials: DW
authors.lastname: Storm
authors.forename: R C
authors.initials: RC
authors.lastname: Maves
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017576:Daptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D009393:Nephritis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D018461:Soft Tissue Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin