title: Progress of FtsZ inhibitors as novel antibiotics leads.
abstract: Bacterial cell division is an attractive target for new antibiotics. FtsZ is a major cytoskeletal protein widespread among archaea and bacteria. FtsZ has a filament-forming GTPase and a structural homologue of eukaryotic tubulin. FtsZ has been validated as a target for antibiotics. This review summarizes the chemical features, binding sites, mechanisms of action, and minimum inhibitory concentration of FtsZ inhibitors.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Weiling
authors.initials: W
authors.lastname: Hong
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D001426:Bacterial Proteins / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020558:GTP Phosphohydrolases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D004791:Enzyme Inhibitors; C071525:FtsZ protein, Bacteria; D020558:GTP Phosphohydrolases