title: Acute renal artery occlusion following infliximab infusion.
abstract: We report the case of a 44-year-old male patient who presented with acute renal artery occlusion, 3 d after first injection of infliximab for steroid refractory attack of ulcerative colitis. Extensive work-up provided no evidence of predisposing factors for arterial thrombosis. Infliximab was thus suspected in the genesis of thrombosis, based on both intrinsic and extrinsic criteria. At month 3 after thrombosis with ongoing anticoagulation, angio-tomodensitometry showed complete revascularization of the left renal artery with renal atrophy. Renal function remained normal and the patient was still in steroid free remission on mercaptopurin monotherapy at maximal follow-up. Few thromboembolic events have been described with anti- tumor necrosis factor (TNF) agents, but it is the first case reported of renal artery thrombosis after infliximab infusion. In addition, we review thrombosis associated with anti-TNF agents.
authors.affiliation: Caroline Lemaitre, Isabelle Iwanicki-Caron, Nathalie Bertiaux-Vandaële, Guillaume Savoye, Department of Gastroenterology, Rouen University Hospital, 76031 Rouen, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lemaitre
authors.forename: Isabelle
authors.initials: I
authors.lastname: Iwanicki-Caron
authors.forename: Clément De
authors.initials: CD
authors.lastname: Vecchi
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bertiaux-Vandaële
authors.forename: Guillaume
authors.initials: G
authors.lastname: Savoye
keywords: Acute renal artery occlusion; Anti-tumor necrosis factor agent; Infliximab; Ulcerative colitis