title: MEFV gene variations in patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  The aim of this study was to investigate the frequency of familial Mediterranean fever (FMF)-associated MEFV gene variations in patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  The study group comprised 190 SLE patients and 101 healthy controls of Turkish origin with no clinical features of FMF. All individuals were genotyped for the four most common MEFV gene variations (M694V, M680I, V726A and E148Q) by PCR-restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The frequency of carrying any of the four MEFV gene variations under study was 15 % in patients with SLE and 10 % in the healthy controls (p = 0.23). After the exclusion of the less penetrant E148Q variation, re-analysis for the three penetrant mutations revealed a significant association between exon 10 variations and pericarditis [p = 0.038, odds ratio (OR) 3.5, 95 % confidence interval (CI) 1.0-12.1], and pleural effusion (p = 0.043, OR 5.2, 95 % CI 0.8-30.9). No significant association was detected between the MEFV gene variations and a higher acute phase response.
  
  
  CONCLUSIONS
  The MEFV gene variations analyzed in our study do not seem to increase the overall susceptibility to SLE and do not have any strong association with its clinical manifestations. The possibility of a modest effect of penetrant exon 10 MEFV variants on the development of serosal effusions needs to be explored in a larger series of patients.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine , Istanbul 34390 , Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Erer
authors.forename: Fulya
authors.initials: F
authors.lastname: Cosan
authors.forename: Basar
authors.initials: B
authors.lastname: Oku
authors.forename: Duran
authors.initials: D
authors.lastname: Ustek
authors.forename: Murat
authors.initials: M
authors.lastname: Inanc
authors.forename: Orhan
authors.initials: O
authors.lastname: Aral
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gul
mesh_terms: D000328:Adult; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010865:Pilot Projects; D000071198:Pyrin
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin