title: Age-related decline in associative learning in healthy Chinese adults.
abstract: Paired associates learning (PAL) has been widely used in aging-related research, suggesting an age-related decline in associative learning. However, there are several cognitive processes (attention, spatial and recognition memory, strategy, and associative learning) involved in PAL. It is unclear which component contributes to the decline in PAL performance associated with age effects. The present study determines whether age effects on associative learning are independent of other cognitive processes involved in PAL. Using a validated computerized cognitive program (CANTAB), we examined cognitive performance of associative learning, spatial and recognition memory, attention and strategy use in 184 Singaporean Chinese adults aged from 21 to 80 years old. Linear regression revealed significant age-related decline in associative learning, spatial and recognition memory, and the level of strategy use. This age-related decline in associative learning remains even after adjusting for attention, spatial and recognition memory, and strategy use. These results show that age effects on associative learning are independent of other cognitive processes involved in PAL.
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Annie
authors.initials: A
authors.lastname: Lee
authors.forename: Jo
authors.initials: J
authors.lastname: Archer
authors.forename: Caroline Kai Yun
authors.initials: CK
authors.lastname: Wong
authors.forename: Shen-Hsing Annabel
authors.initials: SH
authors.lastname: Chen
authors.forename: Anqi
authors.initials: A
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D010153:Paired-Associate Learning / Q000502:physiology*; D021641:Recognition, Psychology; D055815:Young Adult