title: Meta-analysis of the endogenous N200 latency event-related potential subcomponent in patients with Alzheimer's disease and mild cognitive impairment.
abstract: OBJECTIVE
  The N200 latency subcomponent has the potential to be an accurate neurophysiological marker of the cognitive deterioration seen in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
  
  
  METHODS
  Standard mean difference (SMD) estimates of the N200 latency subcomponent were compared in three treatment groups: patients with AD, patients with MCI, and an unrelated elderly control group.
  
  
  RESULTS
  Patients with AD had significantly prolonged N200 latencies compared to the control group, pooled SMD: 0.866 (95% CI: 0.517 to 1.214, z=4.87, p<0.001). Patients with MCI had significantly prolonged N200 latencies compared to the control group, pooled SMD: 0.578 (95% CI: 0.213 to 0.943, z=3.31, p=0.002). When comparing patients with AD and MCI the N200 latencies were similar, pooled SMD: 0.096 (95% CI: -0.261 to 0.453, z=0.53, p=0.598).
  
  
  CONCLUSIONS
  The abnormalities present in the N200 latency subcomponent validate previous research that N200 latency is an informative indicator of information-processing deterioration in patients with cognitive impairment.
  
  
  CONCLUSIONS
  Clinically, measurements of N200 latency can be used as a risk assessment of elderly patients that may be progressing to mild cognitive impairment and/or Alzheimer's disease.
authors.affiliation: Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Canada, M5T 1R8. Electronic address: aaron.howe@camh.ca.
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Howe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D010296:Parietal Lobe / Q000503:physiopathology; D011930:Reaction Time
keywords: Alzheimer’s disease; Cognitive potentials; Event-related potential; Mild cognitive impairment; N200; Neurophysiological marker