title: Selenium modifies carcinogen metabolism by inhibiting enzyme induction.
abstract: Since selenium has been found to exert a protective action against carcinogenesis in various systems, the mechanism where-by sodium selenite inhibits DNA binding of the carcinogen, 7,12-dimethylbenz[a]anthracene, was investigated. It was found that selenite preferentially reduced DNA binding occurring through ananti-dihydrodiol epoxide metabolite of this carcinogen by inhibiting the induction of an enzyme system that generates this specific reactive metabolite.
authors.affiliation: LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, 21701, Frederick, MD.
authors.forename: A
authors.initials: A
authors.lastname: Dipple
authors.forename: M A
authors.initials: MA
authors.lastname: Pigott
authors.forename: J A
authors.initials: JA
authors.lastname: Milner