title: Links between topology of the transition graph and limit cycles in a two-dimensional piecewise affine biological model.
abstract: A class of piecewise affine differential (PWA) models, initially proposed by Glass and Kauffman (in J Theor Biol 39:103-129, 1973), has been widely used for the modelling and the analysis of biological switch-like systems, such as genetic or neural networks. Its mathematical tractability facilitates the qualitative analysis of dynamical behaviors, in particular periodic phenomena which are of prime importance in biology. Notably, a discrete qualitative description of the dynamics, called the transition graph, can be directly associated to this class of PWA systems. Here we present a study of periodic behaviours (i.e. limit cycles) in a class of two-dimensional piecewise affine biological models. Using concavity and continuity properties of Poincaré maps, we derive structural principles linking the topology of the transition graph to the existence, number and stability of limit cycles. These results notably extend previous works on the investigation of structural principles to the case of unequal and regulated decay rates for the 2-dimensional case. Some numerical examples corresponding to minimal models of biological oscillators are treated to illustrate the use of these structural principles.
authors.affiliation: Institut de Biologie de l'Ecole Normale Supérieure, 46 rue d'Ulm, 75230 , Paris Cedex 05, France, wassim.abou-jaoude@polytechnique.org.
authors.forename: Wassim
authors.initials: W
authors.lastname: Abou-Jaoudé
authors.forename: Madalena
authors.initials: M
authors.lastname: Chaves
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Gouzé
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback; D053858:Metabolic Networks and Pathways / Q000502:physiology; D008954:Models, Biological