title: A fluorescence study on the interaction of telmisartan in triblock polymers pluronic P123 and F127.
abstract: Telmisartan is a poorly soluble drug used in treatment of hypertension. There is a recent interest to use pluronic for improving the solubility and bioavailability of these drugs. In this study the interaction of telmisartan with P123 and F127 has been carried out using steady state and time dependent fluorescence study. Quenching of telmisartan fluorescence by potassium iodide is controlled by interactions arising from collisions and complex formation. A comparison of the fluorescence of telmisartan in pluronics with the well understood fluorescence of 8-anilino-1-naphthalene-sulfonic acid, a known fluorescent molecular probe, indicates that telmisartan is generally present in a relatively polar microenvironment with restricted diffusive motion.
authors.affiliation: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: manee_03@yahoo.com.
authors.forename: Maneesha Esther
authors.initials: ME
authors.lastname: Mohanty
authors.affiliation: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: jrao@iict.res.in.
authors.forename: Vaidya Jayathirtha
authors.initials: VJ
authors.lastname: Rao
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Madras, Chennai 600 036, India. Electronic address: mishra@iit.ac.in.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Mishra
mesh_terms: D000817:Anilino Naphthalenesulfonates / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D011060:Poloxalene / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011193:Potassium Iodide / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D000077333:Telmisartan; D013696:Temperature
chemical_list: C515594:8-anilino-1-naphthalenesulfonic acid; D000817:Anilino Naphthalenesulfonates; D001562:Benzimidazoles; D001565:Benzoates; D020442:Poloxamer; D011193:Potassium Iodide; C464484:pluronic block copolymer P123; D011060:Poloxalene; D000077333:Telmisartan
keywords: Fluorescence; Pluronic; Quenching; Telmisartan