title: Investigation on XRCC1 genetic polymorphism and its relationship with breast cancer risk factors in Chinese women.
abstract: Breast cancer (BC) remains one of the most common cancers among women. The human X-ray repair cross-complementing 1 (XRCC1) gene plays key roles in base excision repair, and genetic polymorphisms of XRCC1 may be associated with the susceptibility to BC. This study aimed to evaluate the relationship between the XRCC1 genetic polymorphisms and BC susceptibility. A total of 354 BC patients and 366 cancer-free controls were enrolled in this study. Data about the risk factors of BC were collected using questionnaires. The XRCC1 genetic polymorphism was determined using created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. No significant differences in the allelic and genotypic frequencies of c.1804C>A genetic polymorphism were detected between cases and controls. The distributions of BC patients' risk factors were not significantly different between CC, CA, and AA genotypes. These findings indicate that the c.1804C>A genetic polymorphism of XRCC1 gene is not significantly associated with BC susceptibility in the Chinese women.
authors.affiliation: Department of Breast and Thyroid, Jinan Military General Hospital, Jinan, 250031, Shandong Province, People's Republic of China.
authors.forename: Luming
authors.initials: L
authors.lastname: Zheng
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Xukui
authors.initials: X
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
authors.forename: Pen
authors.initials: P
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Hou
authors.forename: Guowei
authors.initials: G
authors.lastname: Zhao
authors.forename: Qingqing
authors.initials: Q
authors.lastname: He
authors.forename: Baocheng
authors.initials: B
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human