title: Studying neurodegenerative diseases in culture models.
abstract: Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new therapeutic strategies. Although various in vivo models are currently in use, in vitro models might provide important insights about the pathogenesis of these disorders and represent an interesting approach for the screening of potential pharmacological agents. In the present review, we discuss various in vitro and ex vivo models of neurodegenerative disorders in mammalian cells and tissues.
authors.affiliation: Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.
authors.forename: Johannes C M
authors.initials: JC
authors.lastname: Schlachetzki
authors.forename: Soraya Wilke
authors.initials: SW
authors.lastname: Saliba
authors.forename: Antonio Carlos Pinheiro de
authors.initials: AC
authors.lastname: Oliveira
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology*; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000473:pathology*; D000818:Animals; D001253:Astrocytes; D002478:Cells, Cultured; D046508:Culture Techniques / Q000379:methods*; D004195:Disease Models, Animal; D006816:Huntington Disease / Q000209:etiology / Q000473:pathology*; D051379:Mice; D017628:Microglia; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000473:pathology; D010300:Parkinson Disease / Q000209:etiology / Q000473:pathology*; D051381:Rats