title: [Evaluation the effectiveness of radiation therapy high-grade gliomas based on the model of TDF (time-dose fractionation)].
abstract: There were showed the possibility of using the model of TDF, through which it was possible to take into account the selection of fractionation of radiation for high-grade gliomas and to judge the effectiveness of treatment. Currently, the basis of adjuvant radiation therapy in patients with primary high-grade gliomas is the use of the traditional mode of fractionation dose of radiation from a single focal dose of 2 Gy up to a total focal dose of 60 Gy to the tumor (bed of the removed residual tumor) in Grade 4 and Grade 3 - 54 Gy. In patients who underwent radiotherapy using a single focal dose of 3 Gy, overall survival rate was higher as compared to the group of patients, which was carried out using radiotherapy small dose fractionation.
authors.forename: T R
authors.initials: TR
authors.lastname: Izmaĭlov
authors.forename: G A
authors.initials: GA
authors.lastname: Pan'shin
authors.forename: S M
authors.initials: SM
authors.lastname: Misliukov
authors.forename: P V
authors.initials: PV
authors.lastname: Datsenko
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D019583:Dose Fractionation, Radiation; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D060787:Neoplasm Grading; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D016896:Treatment Outcome