title: [Analysis of clinical features and allergic status of asthmatic patients with positive serum mycosis-specific IgE].
abstract: OBJECTIVE
  To improve understanding of the clinical characteristics and diagnosis of allergic bronchopulmonary mycosis (ABPM).
  
  
  METHODS
  We retrospectively analyzed the clinical data, including clinical symptoms, laboratory tests, pulmonary function tests and chest CT imaging of 95 asthmatic patients with positive serum mycosis-specific IgE from January 2010 to September 2012 in Zhongshan Hospital Affiliated to Fudan University.
  
  
  RESULTS
  Of the 95 patients, 59 cases met the diagnostic criteria of ABPM. There were 34 males and 25 females, with a mean age of (53 ± 4) years and a duration of asthma for (21 ± 4) years. Thirty-six cases showed mycosis hypersensitivity (MH). There were 10 males and 26 females, with a mean age of (46 ± 6) years and a duration of asthma for (16 ± 5) years. Clinical symptoms such as wheeze (52 vs 21, χ(2) = 11.159, P = 0.001), cough (54 vs 27, χ(2) = 4.859, P = 0.030) and expectoration (43 vs 9, χ(2) = 25.731, P = 0.000) were more common in the ABPM group compared to the MH group.In the ABPM group, 58 were A. fumigatus-specific IgE antibody positive, 34 Penicillium-specific IgE antibody positive and 1 only Penicillium-specific IgE antibody positive.While in the MH group, 15 were A.fumigatus-specific IgE antibody positive, 24 Penicillium-specific IgE antibody positive and 17 only Penicillium-specific IgE antibody positive.In the ABPM group, the percentage of positive fumigatus-specific IgE antibody was higher (58 vs 15, χ(2) = 24.500, P = 0.000), while the percentages of dermatophagoides pteronyssinus(21 vs 20, χ(2) = 3.632, P = 0.045) and Dermatophagoides farinae(17 vs 21, χ(2) = 8.118, P = 0.004) were lower. Total serum IgE [(4395 ± 1437) IU/ml vs (276 ± 133) IU/ml, T = 4.384, P = 0.000], peripheral eosinophil percentage[(12.56 ± 1.20)% vs (1.30 ± 0.15)%, t = 8.175, P = 0.000] and count [(2.09 ± 0.43)×10(9)/L vs (0.19 ± 0.04)×10(9)/L, t = 7.032, P = 0.000] were higher in the ABPM group as compared to the MH group.FEV1% slightly declined in the ABPM group [(70.2 ± 2.3)% vs (78.3 ± 3.2%)%, t = 2.011, P = 0.038].Forty-one cases (69.50%) had central bronchiectasis and 18 (30.50%) had mucus plugs in the ABPM group. Chest CT scan was normal in the MH group.
  
  
  CONCLUSIONS
  ABPM is common in asthmatic patients but has long been underestimated and misdiagnosed.Efforts need to be intensified to improve the awareness among clinicians for early diagnosis and treatment of the disease.
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mou
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Gong
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Mei-ling
authors.initials: ML
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000276:immunology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D001232:Aspergillus fumigatus / Q000276:immunology; D001249:Asthma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E