title: Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy.
abstract: The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.
authors.affiliation: Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3052, Australia. Electronic address: andrew.neal@mh.org.au.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Neal
authors.affiliation: Department of Palliative and Supportive Care, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia.
authors.forename: Mary Y
authors.initials: MY
authors.lastname: Qian
authors.affiliation: Department of Palliative and Supportive Care, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Clinch
authors.affiliation: Department of Palliative and Supportive Care, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia.
authors.forename: Brian H
authors.initials: BH
authors.lastname: Le
mesh_terms: D000368:Aged; D006801:Humans; D006867:Hydrolases; D007024:Hypotension, Orthostatic / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins / Q000097:blood*; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
chemical_list: D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases
keywords: Autonomic neuropathy; CRMP-5; Orthostatic hypotension; Paraneoplastic