title: Methotrexate in refractory bilateral juvenile temporal arteritis: Report of a case.
abstract: Juvenile temporal arteritis is a rare inflammatory disease of the temporal arteries that affects young adults. The clinical course is benign and the surgical excision of the affected artery is usually curative. Here we report a case of bilateral juvenile temporal arteritis with significant peripheral eosinophilia and elevated IgE, refractory to surgical excision and even to a short course of corticosteroids. Methotrexate, added as a steroid-sparing agent, resulted in a good disease control.
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Campochiaro
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Guglielmi
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Alvise
authors.initials: A
authors.lastname: Berti
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Cavalli
authors.affiliation: b Unit of Neuroradiology, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Gerevini
authors.affiliation: c Unit of Pathology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Doglioni
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Sabbadini
authors.affiliation: a Unit of Medicine and Clinical Immunology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute , Milan , Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Dagna
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D013700:Giant Cell Arteritis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D019233:Retreatment; D013699:Temporal Arteries / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D008727:Methotrexate
keywords: Juvenile arteritis; Methotrexate; Temporal arteritis