title: Anticonvulsant and neuroprotective effects of oligosaccharides from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes).
abstract: An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)-1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10-80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.
authors.affiliation: Centro de Investigaciones Biologicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México.
authors.forename: Isaac
authors.initials: I
authors.lastname: Tello
authors.forename: Victoria
authors.initials: V
authors.lastname: Campos-Pena
authors.forename: Elizur
authors.initials: E
authors.lastname: Montiel
authors.forename: Veronica
authors.initials: V
authors.lastname: Rodriguez
authors.forename: Alma
authors.initials: A
authors.lastname: Aguirre-Moreno
authors.forename: Ismael
authors.initials: I
authors.lastname: Leon-Rivera
authors.forename: Federico
authors.initials: F
authors.lastname: Del Rio-Portilla
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.forename: Juana
authors.initials: J
authors.lastname: Villeda-Hernandez
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000378:metabolism; D007608:Kainic Acid; D008297:Male; D025282:Mycelium; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D020940:Reishi / Q000737:chemistry*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D001688:Biological Products; D004365:Drugs, Chinese Herbal; D053583:Interleukin-1beta; D018696:Neuroprotective Agents; D009844:Oligosaccharides; D014409:Tumor Necrosis Factor-alpha; D007608:Kainic Acid