title: Multi-residue analysis of emerging pollutants in sediment using QuEChERS-based extraction followed by LC-MS/MS analysis.
abstract: Emerging contaminants are suspected to cause adverse effects in humans and wildlife. Aquatic ecosystems are continuously contaminated by agricultural and industrial sources. To establish a causality relationship between the occurrence of contaminants in the environment and disease, experiments including all environmental matrices must be performed. Consequently, the current analytical tools must be improved. A new multi-residue method for analysing 15 emerging pollutants in sediments based on the Quick, Easy, Cheap, Effective, Rugged and Safe approach is reported. The development of such a multirisque, inter-family method for sediment including pharmaceuticals, pesticides, personal care products and plasticizers is reported for the first time. The procedure involves salting-out liquid-liquid extraction using acetonitrile and clean-up with dispersive solid phase extraction, followed by liquid chromatography coupled with tandem mass spectrometry. The validated analytical procedure exhibited recoveries between 40 and 98% for every target compound. This methodology facilitated the determination of pollutant contents at nanogram-per-gram concentrations.
authors.affiliation: Université de Lyon-Institut des Sciences Analytiques, UMR 5280 CNRS-Equipe TRACES, Université Lyon1, ENS-Lyon - 5 rue de la Doua, 69100, Villeurbanne, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Berlioz-Barbier
authors.forename: Antoine
authors.initials: A
authors.lastname: Vauchez
authors.forename: Laure
authors.initials: L
authors.lastname: Wiest
authors.forename: Robert
authors.initials: R
authors.lastname: Baudot
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Vulliet
authors.forename: Cécile
authors.initials: C
authors.lastname: Cren-Olivé
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004350:Drug Residues / Q000032:analysis / Q000302:isolation & purification*; D019015:Geologic Sediments / Q000737:chemistry*; D059625:Liquid-Liquid Extraction / Q000379:methods*; D052616:Solid Phase Extraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000302:isolation & purification*
chemical_list: D014874:Water Pollutants, Chemical