title: Biscembranoids from the marine sponge Petrosia nigricans.
abstract: One new biscembranoid, petronigrione (1), and five known compounds, methyl tortuoate B (2), lobophytone U (3), lobophytone H (4), (24S)-ergostane 3beta, 5alpha, 6beta, 25 tetraol-25-monoacetate (5), and (24S)-ergostane-1beta, 3beta, 5alpha, 6beta, 25-pentaol-25-monoacetate (6), were isolated from the methanol extract of the marine sponge Petrosia nigricans. Their structures were established on the basis of spectral and chemical evidence. The cytotoxicity of all compounds was evaluated by MTT assay on four human cancer cell lines, HepG2, KB, LU-1, and MCF-7. Compounds 1 and 2 exhibited moderate cytotoxic activities on the four human cancer cell lines with IC50 values ranging of 20.7 - 28.9 microg/mL.
authors.affiliation: lnstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Ngo Van
authors.initials: NV
authors.lastname: Quang
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Dan Thi Thuy
authors.initials: DT
authors.lastname: Hang
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Hoai
authors.forename: Do Cong
authors.initials: do C
authors.lastname: Thung
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D047130:Petrosia / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C585667:petronigrione