title: Spontaneous resolution of lupus nephritis following withdrawal of etanercept.
abstract: BACKGROUND
  Etanercept, a systemic inhibitor of α-TNF, is used for treatment of various autoimmune disorders. We report a case of spontaneous resolution of etanercept-induced lupus nephritis.
  
  
  METHODS
  A 57-year-old female patient taking etanercept for psoriasis presented with laboratory-and histology-confirmed lupus nephritis. After stopping etanercept, there was normalization of proteinuria, hematuria, serum complements, anti-dsDNA antibody, and resolution of the acute glomerular inflammatory process on repeat kidney biopsy.
  
  
  CONCLUSIONS
  This case demonstrates serology- and biopsy-confirmed resolution of active lupus nephritis upon withdrawal of etanercept.
authors.affiliation: Geisinger Medical Center, Suite 13-48, 100 N Academy Ave, Danville, PA 17822, USA; e mail: tmyahya@geisinger.edu.
authors.forename: Taher M
authors.initials: TM
authors.lastname: Yahya
authors.forename: Susmitha
authors.initials: S
authors.lastname: Dhanyamraju
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Harrington
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Prichard
mesh_terms: D001323:Autoantibodies / Q000187:drug effects / Q000276:immunology*; D001774:Blood Chemical Analysis; D003401:Creatine / Q000097:blood; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000648:ultrastructure; D008181:Lupus Nephritis / Q000139:chemically induced* / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D016482:Urinalysis
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D003401:Creatine; D000068800:Etanercept
keywords: etanercept; glomerulonephritis; kidney biopsy; lupus nephritis