title: An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia.
abstract: Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China ; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Jiewei
authors.initials: J
authors.lastname: Liu
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Zheng
authors.forename: Xiongjian
authors.initials: X
authors.lastname: Luo
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Ayako
authors.initials: A
authors.lastname: Nunokawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Bei
authors.forename: Siow-Ann
authors.initials: SA
authors.lastname: Chong
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lee
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Su
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*