title: Glomerular disease: the role of parietal epithelial cells in hyperplastic lesions.
abstract: Parietal epithelial cells (PECs) are increasingly recognized as key players in the pathogenesis of proliferative glomerular diseases. A new study by Rizzo and colleagues contributes to this emerging concept and identifies potential novel signalling pathways that might mediate the activation of PECs. However, the functional role of PECs remains controversial.
authors.affiliation: Department of Nephrology and Clinical Immunology, RWTH University Hospital, Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Moeller
authors.affiliation: Department of Nephrology and Clinical Immunology, RWTH University Hospital, Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kuppe
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004847:Epithelial Cells; D005260:Female; D005920:Glomerular Mesangium; D005921:Glomerulonephritis; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D013234:Stem Cells
chemical_list: D018836:Inflammation Mediators