title: Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis.
abstract: The aim of this study was to examine the role of single nucleotide polymorphisms (SNPs) and haplotypes of the tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene in Hungarians with psoriasis and psoriatic arthritis. A case-control study was performed, and five TNFSF15 SNPs (rs3810936, rs6478108, rs6478109, rs7848647, rs7869487) were genotyped in 319 patients with psoriasis, 105 of whom also have psoriatic arthritis, and in 200 healthy individuals. Three haplotypes (A, B, C) based on these five SNPs were also analyzed. Our findings suggest that the rs6478109 SNP may be a genetic risk factor in psoriasis (p=0.0046), while haplotype C may be protective (p=0.0250). These results suggest that certain variants of the TNFSF15 gene contribute to the pathogenesis of the immune-mediated, multifactorial skin disease psoriasis, and that this difference is more readily apparent when groups of patients with and without psoriatic arthritis are examined separately.
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Hungary. Electronic address: kepirolaszlo@mail.derma.szote.u-szeged.hu.
authors.forename: László
authors.initials: L
authors.lastname: Képíró
authors.affiliation: MTA-SZTE Dermatological Research Group, University of Szeged, Hungary; Department of Medical Genetics, University of Szeged, Hungary.
authors.forename: Márta
authors.initials: M
authors.lastname: Széll
authors.affiliation: Department of Rheumatology, University of Szeged, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Kovács
authors.affiliation: Department of Rheumatology, Pándy Kálmán Békés County Hospital, Gyula, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Keszthelyi
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Hungary; MTA-SZTE Dermatological Research Group, University of Szeged, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Kemény
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Hungary; Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Hungary.
authors.forename: Rolland
authors.initials: R
authors.lastname: Gyulai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015535:Arthritis, Psoriatic / Q000235:genetics / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000235:genetics*; D055815:Young Adult
chemical_list: C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15
keywords: CASPAR; CD; Classification Criteria for Psoriatic Arthritis; Crohn’s disease; DR3; HLA; IBD; PASI; Psoriasis Area Severity Index; SNP; TL1A; TNF; TNF superfamily ligand A; TNFSF15; UC; VEGI; death domain receptor 3; human leukocyte antigen; inflammatory bowel disease; single nucleotide polymorphism; tumor necrosis factor; tumor necrosis factor superfamily, member 15; ulcerative colitis; vascular endothelial cell growth inhibitor