title: Vitapex can promote the expression of BMP-2 during the bone regeneration of periapical lesions in rats.
abstract: OBJECTIVE
  To investigate the effect of Vitapex on the healing of periapical lesions and the expression of bone morphogenetic protein (BMP-2) during the periapical bone regeneration.
  
  
  METHODS
  Periapical lesions were induced in Sprague-Dawley (S-D) rats by an occlusal pulp exposure in the mandibular ﬁrst molars and were verified by X-ray. Total of 36 rats were randomly divided into three groups, and they were obturated with Zinc Oxide Eugenol (ZOE), or with Vitapex, or non-treated as negative control group. The rats of three groups were randomly killed at week 0, 2, 4, and 8 after root canal therapy, and then the mandibles were processed for histological examination and immunohistochemistry analysis.
  
  
  RESULTS
  At week 0, only a few BMP-2 positive cells could be observed in all rats. While the expression of BMP-2 was dramatically increased in case of Vitapex group at week 2 and week 4, and then climaxed at week 8. However, no apparent changes were observed in ZOE group and negative group at week 2, 4, and 8.
  
  
  CONCLUSIONS
  These observations suggested that Vitapex has a greater ability in inducing bone regeneration than ZOE by the expression of BMP-2 induction in the treatment of rats experimental periapical lesions.
authors.affiliation: Department of Dentistry, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xianyin
authors.initials: X
authors.lastname: Xia
authors.forename: Zhaozhao
authors.initials: Z
authors.lastname: Man
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.forename: Ruirui
authors.initials: R
authors.lastname: Du
authors.forename: Wenjing
authors.initials: W
authors.lastname: Sun
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism*; D001861:Bone Regeneration / Q000187:drug effects*; D002126:Calcium Hydroxide / Q000494:pharmacology*; D005260:Female; D010483:Periapical Diseases / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012387:Root Canal Filling Materials / Q000494:pharmacology; D012828:Silicones / Q000494:pharmacology*
chemical_list: C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D012387:Root Canal Filling Materials; D012828:Silicones; C029584:calcium hydroxide, iodoform, silicone oil drug combination; D002126:Calcium Hydroxide