title: The value of serum prealbumin in the diagnosis and therapeutic response of tuberculosis: a retrospective study.
abstract: OBJECTIVE
  The aim of this study was to examine serum prealbumin (PA) levels in patients with tuberculosis and lung cancer, and to evaluate the correlations of serum PA levels with clinicopathological characteristics.
  
  
  METHODS
  Total 760 patients were included in the study: 320 patients with tuberculosis, 320 patients with lung cancer, and 120 healthy subjects. Serum PA was detected using a biochemical analyzer to determine the value of serum PA in the diagnosis and therapeutic response of tuberculosis.
  
  
  RESULTS
  Compared to lung cancer and healthy individuals, TB patients were more frequent in suffering from low serum PA (75.0% vs.30.9% vs.6.7%,P<0.01), and the serum PA levels of TB patients were significantly reduced (137.5 ± 42.4 mg/L vs. 183.5 ± 49.1 mg/L vs. 240.0 ± 43.9 mg/L, P<0.01). Among various clinical characteristics, type (with pleuritis), age (≥ 60), ESR (>20 mm/h) and smoking status (≥ 20 pack × years) were associated with low serum PA levels of TB patients, while ECOG performance status (≥ 2) was associated with low serum PA levels of lung cancer patients. The change of serum PA levels was in accordance with the therapeutic effects of anti-TB drugs, which might present a valuable and objective indicator for monitoring the therapeutic effects of TB drugs on TB patients.
  
  
  CONCLUSIONS
  Low serum prealbumin levels are very common in TB patients and can be served as a potential indicator for differential diagnosis of lung cancer and monitoring the therapeutic effects of TB drugs.
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Luo
authors.forename: Bingjing
authors.initials: B
authors.lastname: Zhu
authors.forename: Liang
authors.initials: L
authors.lastname: Gong
authors.forename: Jingxiang
authors.initials: J
authors.lastname: Yang
authors.forename: Yongyuan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism*; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents; D011228:Prealbumin