title: Chronic rhinosinusitis confers an increased risk of acute myocardial infarction.
abstract: BACKGROUND
  The link between chronic inflammatory disease and cardiovascular disease (CVD) is recognized. Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases. However, whether CRS increases the risk for CVD is still unknown. This epidemiology study investigated the risk for acute myocardial infarction (AMI) in patients with CRS using a large-scale population-based cohort study.
  
  
  METHODS
  Data on all study cohorts were retrieved from the Longitudinal Health Insurance Database in Taiwan. In total, data on 7975 CRS subjects from 2001 to 2003 were extracted for the study cohort. We selected 39,875 comparison subjects whose demographic variables matched those of the study cohort. We individually tracked each subject for a 6-year period (from 2001 to 2009) to identify which subjects subsequently received a diagnosis of AMI. A stratified Cox proportional hazards regression was used to compare the 6-year risk of a subsequent AMI after a diagnosis of CRS.
  
  
  RESULTS
  Among the 47,850 sampled subjects, the incidence rate of AMI during the 6-year follow-up period was 5.66/1000 person-years; rates were 8.49 and 5.09/1000 person-years for the study and comparison cohort, respectively. The hazard ratio (HR) for AMI during the 6-year follow-up period for subjects with CRS was 1.70 (95% confidence interval [CI], 1.52~1.91). In addition, after adjusting for cardiovascular risk factors, the HR of AMI for subjects with CRS was 1.48 (95% CI, 1.32~1.67) compared with subjects without CRS.
  
  
  CONCLUSIONS
  Patients with CRS were at higher risk for AMI occurrence in the 6-year follow-up.
authors.affiliation: Department of Family Medicine, PoJen General Hospital, Taipei, Taiwan.
authors.forename: Pi-Chieh
authors.initials: PC
authors.lastname: Wang
authors.forename: Herng-Ching
authors.initials: HC
authors.lastname: Lin
authors.forename: Jiunn-Horng
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications*; D012306:Risk; D012852:Sinusitis / Q000150:complications*