title: HLA-B50 polymorphism in the Saudi population.
abstract: The HLA-B50 serologic family is very frequent in people of Arabic origin. In Saudi Arabia, HLA-B50 is the most frequent HLA-B allele. The aim of this study was to investigate the distribution of HLA-B50 alleles in healthy Saudi individuals. A total of 162 healthy Saudi individuals were selected based on low-resolution HLA typing. DNA samples were typed by sequence-based typing method for exons 2, 3 and 4 of the HLA-B locus (Genome Diagnostics B.V.). The HLA-B*50 alleles were analysed using SBT engine software. HLA-B*50:01:01 was found in 161 of 162 individuals (99.4%), while HLA-B*50:09 was found in one individual (0.6%). HLA-B*50:01:01 is the most common HLA-B50 allele in Saudi Arabia.
authors.affiliation: King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
authors.forename: D
authors.initials: D
authors.lastname: Jawdat
authors.forename: B
authors.initials: B
authors.lastname: Al-Hamad
authors.forename: M
authors.initials: M
authors.lastname: Al-Jumah
authors.forename: A
authors.initials: A
authors.lastname: Hajeer
mesh_terms: D000483:Alleles; D005091:Exons; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D011110:Polymorphism, Genetic; D012529:Saudi Arabia
chemical_list: D015235:HLA-B Antigens