title: Effects of losartan on the mobilization of endothelial progenitor cells and improvement of endothelial function.
abstract: Through investigating the effect of the angiotensin receptor blocker (ARB) losartan on the number of endothelial progenitor cells (EPCs) and blood flow-mediated endothelium-dependent function (FMD) in the peripheral blood of patients with coronary heart disease (CHD), we found that FMD was improved and the number of circulating EPCs increased in the ARB treatment group (P <0.05). In addition, the increase in the number of EPCs was positively correlated with the improvement of FMD in the ARB treatment group (r = 0.52, P <0.01). These findings suggest that losartan may mobilize EPCs in the peripheral blood, improving endothelial function in CHD.
authors.affiliation: Department of Cardiology, the General Hospital of Ji'nan Military Region, Ji'nan 250031, Shangdong, China; e mail: haosination@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Tan
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiuying
authors.initials: X
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Jin
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D001916:Brachial Artery / Q000473:pathology; D002681:China; D003327:Coronary Disease / Q000188:drug therapy* / Q000473:pathology; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan
keywords: Losartan; blood flow-mediated endothelium-dependent function (FMD); coronary artery disease (CHD); endothelial progenitor cell (EPCs)