title: Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities.
abstract: Two flavones, ladanein and 6-hydroxy-5,7,4'-trimethoxyflavone and one labdane-type diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their (1)H and (13)C-NMR data, EI mass and UV spectral data. The compounds have been subjected to antimicrobial, antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidants compared with the isolated diterpene.
authors.affiliation: Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Farjam
authors.forename: Abdolhossein
authors.initials: A
authors.lastname: Rustaiyan
authors.forename: Elham
authors.initials: E
authors.lastname: Ezzatzadeh
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jassbi
keywords: 4′-trimethoxyflavone; 6-hydroxy-5; 7; Antimicrobial; Antioxidant; Cytotoxic; Ent-13-epi-manoyloxide; TLadanein