title: Analysis of symmetries in models of multi-strain infections.
abstract: In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights. Using the example of a generic model of multi-strain diseases with cross-immunity between strains, we show that a significant understanding of the stability of steady states and possible dynamical behaviours can be achieved when the symmetry of interactions between strains is taken into account. Techniques of equivariant bifurcation theory allow one to identify the type of possible symmetry-breaking Hopf bifurcation, as well as to classify different periodic solutions in terms of their spatial and temporal symmetries. The approach is also illustrated on other models of multi-strain diseases, where the same methodology provides a systematic understanding of bifurcation scenarios and periodic behaviours. The results of the analysis are quite generic, and have wider implications for understanding the dynamics of a large class of models of multi-strain diseases.
authors.affiliation: Department of Mathematics, University of Sussex, Falmer, Brighton , BN1 9QH, UK, k.blyuss@sussex.ac.uk.
authors.forename: Konstantin B
authors.initials: KB
authors.lastname: Blyuss
mesh_terms: D000940:Antigenic Variation / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology*; D003198:Computer Simulation; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological