title: A randomized controlled trial on immediate surgery versus root planing in patients with advanced periodontal disease: a cost-effectiveness analysis.
abstract: OBJECTIVE
  To compare immediate surgery to scaling and root planing (SRP) in the treatment of advanced periodontal disease focusing on the prevalence of residual sites and cost-effectiveness (1); to evaluate the adjunctive effects of azithromycin in a second treatment phase (2).
  
  
  METHODS
  Thirty-nine patients (18 males, 21 females; mean age: 54.6) received oral hygiene instructions and were randomly allocated to surgery (n = 19) or SRP (n = 20). Patients with residual pockets (≥6 mm) at 6 months received re-debridement of these sites and systemic azithromycin. Treatment groups were followed up to 12 months and evaluated in terms of clinical response parameters and cost-effectiveness. Chair-time was used to assess the financial impact of treatment.
  
  
  RESULTS
  Both treatment arms were equally effective in terms of clinical outcome demonstrating less than 1% residual pockets at 12 months. Surgery imposed an extra 746 Euro on the patient up to 6 months when compared to SRP. At 12 months, 46 Euro of this amount could be offset as a result of a reduced need for supportive care. Only 6 patients in the surgery group needed systemic antibiotics, whereas 14 patients in the SRP needed such additional treatment.
  
  
  CONCLUSIONS
  Although 700 Euro could be saved on average by performing SRP instead of surgery, the latter significantly reduced the need for supportive care and systemic antibiotics.
authors.affiliation: Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Miremadi
authors.forename: Hugo
authors.initials: H
authors.lastname: De Bruyn
authors.forename: Harold
authors.initials: H
authors.lastname: Steyaert
authors.forename: Katrijn
authors.initials: K
authors.lastname: Princen
authors.forename: Mehran M
authors.initials: MM
authors.lastname: Sabzevar
authors.forename: Jan
authors.initials: J
authors.lastname: Cosyn
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use; D017963:Azithromycin / Q000191:economics / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000191:economics / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy / Q000191:economics; D003362:Cost-Benefit Analysis; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000191:economics / Q000379:methods*; D016527:Drug Costs; D005260:Female; D005500:Follow-Up Studies; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000601:surgery / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery / Q000628:therapy; D011446:Prospective Studies; D016745:Root Planing / Q000191:economics / Q000379:methods*; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin
keywords: azithromycin; cost effectiveness; periodontitis; randomized controlled trial; scaling and root planing; surgery