title: Pharmacokinetics of anthracyclines in dogs: evidence for structure-related body distribution and reduction to their hydroxy metabolites.
abstract: The pharmacokinetic disposition of the anthracyclines, adriamycin (doxorubicin), daunorubicin, 4'-epi-adriamycin, carminomycin, and 4-demethoxy-daunorubicin, and the formation of their reduced C13 hydroxy metabolites were studied in dogs. The presence of a C14hydroxy group (adriamycin and 4'epi-adriamycin) drastically reduces the appearance of the C13 hydroxy metabolites in plasma. Substitution of the C4-H with C4-OH and C4-OCH3, in this rank order, decreases the area under the plasma concentration-time curves of the parent compounds and their C13 hydroxy metabolites.
authors.affiliation: Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Oosterbaan
authors.forename: R J
authors.initials: RJ
authors.lastname: Dirks
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
authors.forename: E
authors.initials: E
authors.lastname: van der Kleijn