title: Efficacy of goshajinkigan for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.
abstract: Objective. To evaluate the efficacy of Goshajinkigan for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients. Patients. Colorectal cancer patients (N = 29) who received ≥4 weeks of Goshajinkigan for oxaliplatin-induced peripheral neuropathy during chemotherapy at Kyoto Prefectural University of Medicine were (Goshajinkigan group) compared to 44 patients who had not received Goshajinkigan during the same period (non-Goshajinkigan group). Main Outcome Measures. The effect of Goshajinkigan was graded as curative, effective, stabilizing, or deleterious. The relationships between the grade of peripheral neuropathy and the dose of oxaliplatin in the Goshajinkigan and non-Goshajinkigan groups were evaluated. Results. The effect of Goshajinkigan on peripheral neuropathy in the Goshajinkigan group was curative, effective, stabilizing, and deleterious in 3.4, 20.7, 69.0, and 6.9% of patients, compared to the effect in the non-Goshajinkigan group (4.5, 15.9, 45.5, and 34.1%). The ratio of deleterious effects was significantly different between these two groups (P = 0.04). A Kaplan-Meier analysis in relation to the cumulative dose of oxaliplatin showed that the incidence of grade 3 peripheral neuropathy tended to be less in the Goshajinkigan group (P = 0.05). There were no significant differences in time to treatment failure and severe adverse events between these two groups. Conclusions. Goshajinkigan prevented exacerbation of oxaliplatin-induced peripheral neuropathy. This trial is registered with UMIN000009956.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan ; Outpatient Oncology Unit, Kyoto Prefectural University of Medicine Hospital, Kyoto 602-8566, Japan.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yagi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kokura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Kokuba
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Haruo
authors.initials: H
authors.lastname: Kuroboshi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Taguchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Hosoi
authors.forename: Terukazu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tsuneharu
authors.initials: T
authors.lastname: Miki