title: Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses.
abstract: The innate system's recognition of non-self and danger signals is mediated by a limited number of germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen associated molecular patterns (PAMPs). Toll-like receptors (TLRs) are single, non-catalytic, membrane-spanning PRRs present in invertebrates and vertebrates. They act by specifically recognizing PAMPs of a variety of microbes and activate signaling cascades to induce innate immunity. A large number of TLRs have been identified in various aquatic animals of phyla Cnidaria, Annelida, Mollusca, Arthropoda, Echinodermata and Chordata. TLRs of aquatic and warm-blooded higher animals exhibit some distinctive features due to their diverse evolutionary lineages. However, majority of them share conserve signaling pathways in pathogen recognition and innate immunity. Functional analysis of novel TLRs in aquatic animals is very important in understanding the comparative immunology between warm-blooded and aquatic animals. In additions to innate immunity, recent reports have highlighted the additional roles of TLRs in adaptive immunity. Therefore, vaccines against many critical diseases of aquatic animals may be made more effective by supplementing TLR activators which will stimulate dendritic cells. This article describes updated information of TLRs in aquatic animals and their structural and functional relationship with warm-blooded animals.
authors.affiliation: Department of Life Science, National Institute of Technology, Rourkela 769 008, Odisha, India.
authors.forename: Pradipta R
authors.initials: PR
authors.lastname: Rauta
authors.affiliation: Fish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751 002, Odisha, India.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Samanta
authors.affiliation: Department of Life Science, National Institute of Technology, Rourkela 769 008, Odisha, India.
authors.forename: Hirak R
authors.initials: HR
authors.lastname: Dash
authors.affiliation: Department of Life Science, National Institute of Technology, Rourkela 769 008, Odisha, India.
authors.forename: Bismita
authors.initials: B
authors.lastname: Nayak
authors.affiliation: Department of Life Science, National Institute of Technology, Rourkela 769 008, Odisha, India. Electronic address: surajit@nitrkl.ac.in.
authors.forename: Surajit
authors.initials: S
authors.lastname: Das
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000276:immunology*; D005075:Biological Evolution; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007109:Immunity; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors
keywords: Aquatic animals; Fish; Innate immunity; Toll-like receptors