title: Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery.
abstract: OBJECTIVE
  Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer.
  
  
  METHODS
  In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m²) and overweight or obese (BMI ≥ 23.0 kg/m²). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed.
  
  
  RESULTS
  A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases.
  
  
  CONCLUSIONS
  A high BMI (≥ 23.0 kg/m²) is independently associated with poor prognosis in hormone receptor-positive breast cancer.
authors.affiliation: . xingpeng1983@hotmail.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Xing
authors.forename: Ji-Guang
authors.initials: JG
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Zhao
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Dong
authors.forename: Xiao Lin
authors.initials: XL
authors.lastname: Wei
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies