title: Low ADAMTS-13 in plavix induced thrombotic thrombocytopenic purpura.
abstract: Thrombotic thrombocytopenia purpura (TTP) was first described in 1924 as a "pathologic alteration of the microvasculature, with detachment or swelling of the endothelium, amorphous material in the sub-endothelial space, and luminal platelet aggregation leading to compromise of the microcirculation". Ticlopidine induced TTP has been highly associated with autoimmune induced reduction in ADAMTS-13 activity. These findings, to a lesser extent, have also been found in clopidogrel induced TTP. We report a case of clopidogrel associated TTP in a patient that presented with acute stroke, renal failure, and non-ST elevation myocardial infarction.
authors.affiliation: Long Bao Cao, Christopher Jones, Assad Movahed, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States.
authors.forename: Long Bao
authors.initials: LB
authors.lastname: Cao
authors.forename: Christopher
authors.initials: C
authors.lastname: Jones
authors.forename: Assad
authors.initials: A
authors.lastname: Movahed
keywords: Antiplatelet therapy; Plavix; Thrombotic thrombocytopenic purpura