title: Anxiety disorders and rapid cycling: data from a cohort of 8129 youths with bipolar disorder.
abstract: Anxiety disorders (ADs) are common in youths with bipolar disorder (BD). We examine psychiatric comorbidity, hospitalization, and treatment in youths with versus without AD and rapid cycling (four or more cycles per year). Data from the Integrated Healthcare Information Services cohort were used and included 8129 youths (ages ≤18 years). Prevalence of AD, demographic, type of AD, hospitalization, and use of psychotropics were compared between rapid and nonrapid cycling. Overall, 51% of the youths met criteria for at least one comorbid AD; they were predominantly female and were between 12 and 17 years of age. The most common comorbid ADs were generalized ADs and separation ADs. In the patients with rapid cycling, 65.5% met criteria for comorbid AD. The BD youths with AD were more likely to have major depressive disorders and other comorbid ADs, to be given more psychotropics, and to be hospitalized for depression and medical conditions more often than were those without AD.
authors.affiliation: *Temple University, Fort Washington, PA; †Institute of Psychiatry, King's College London, London, UK; ‡Sun Valley Behavioral & Research Center, Imperial, CA; §Pontificia Universidad Javeriana, Bogota, Colombia; and ∥University of California, San Diego, CA.
authors.forename: Ruby
authors.initials: R
authors.lastname: Castilla-Puentes
authors.forename: Regina
authors.initials: R
authors.lastname: Sala
authors.forename: Bernardo
authors.initials: B
authors.lastname: Ng
authors.forename: Juan
authors.initials: J
authors.lastname: Galvez
authors.forename: Alvaro
authors.initials: A
authors.lastname: Camacho
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D001010:Anxiety, Separation / Q000453:epidemiology / Q000523:psychology; D001714:Bipolar Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D002648:Child; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male