title: Post-mortem MRI as an alternative to non-forensic autopsy in foetuses and children: from research into clinical practice.
abstract: Although post-mortem MRI (PMMR) was proposed as an alternative to conventional autopsy more than a decade ago, the lack of systematic validation has limited its clinical uptake. Minimally invasive autopsy (MIA) using PMMR together with ancillary investigations has now been shown to be as accurate as conventional autopsy in foetuses, newborns and infants and is particularly useful for cerebral, cardiac and genitourinary imaging. Unlike conventional autopsy, PMMR provides a permanent three-dimensional auditable record, with accurate estimation of internal organ volumes. MIA is becoming highly acceptable to parents and professionals, and there is widespread political support and public interest in its clinical implementation in the UK. In the short to medium term, it is desirable that a supraregional network of specialist centres should be established to provide this service within the current National Health Service framework.
authors.affiliation: Perinatal Neurology and Neonatology, Imperial College London, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Addison
authors.forename: O J
authors.initials: OJ
authors.lastname: Arthurs
authors.forename: S
authors.initials: S
authors.lastname: Thayyil
mesh_terms: D001344:Autopsy / Q000379:methods / Q000592:standards; D002648:Child; D005313:Fetal Death / Q000473:pathology; D005333:Fetus; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D009929:Organ Size; D051598:Whole Body Imaging / Q000379:methods