title: Long-term outcome of endoscopic resection of superficial adenocarcinoma of the esophagogastric junction.
abstract: OBJECTIVE
  Endoscopic resection has been favored for the management of intramucosal adenocarcinoma of the esophagogastric junction (AEGJ) over standard treatment with surgical resection. Several previous studies have reported only short-term outcomes. The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ.
  
  
  METHODS
  A retrospective cohort study included 53 consecutive patients with superficial AEGJ who underwent ESD between 2001 and 2007 at the National Cancer Center Hospital, Tokyo, Japan. Rates of overall survival, recurrence-free survival, and cause-specific survival of patients with AEGJ after endoscopic resection were analyzed.
  
  
  RESULTS
  The 5-year overall, recurrence-free, and cause-specific survival rates in the 53 patients were 94.2%, 92.3% and 96.1%, respectively. The median follow-up was 6.1 years. En bloc, R0, and curative resection rates were 100 %, 79 %, 68 %, respectively. In 36 patients with curative resection, the cause-specific survival rate was 100 % and no recurrence or metastases were detected. In 17 patients with non-curative resection, recurrence was found in three patients (17 %); two of the three patients died of their disease whilst one patient received chemotherapy.
  
  
  CONCLUSIONS
  Superficial AEGJ can be well controlled by ESD when curative resection is achieved.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Oda
authors.forename: Satoru
authors.initials: S
authors.lastname: Nonaka
authors.forename: Haruhisha
authors.initials: H
authors.lastname: Suzuki
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yoshinaga
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sekine
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Takuji
authors.initials: T
authors.lastname: Gotoda
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D004210:Dissection; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000601:surgery*; D004943:Esophagogastric Junction / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome