title: Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets.
abstract: In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Science, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
authors.forename: Jos
authors.initials: J
authors.lastname: Prickaerts
authors.affiliation: Emotion & Cognition Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, University Utrecht, P.O. Box 80151, Utrecht, The Netherlands; Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
authors.forename: Elise T
authors.initials: ET
authors.lastname: Gieling
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Science, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
authors.forename: Ann K
authors.initials: AK
authors.lastname: Bruder
authors.affiliation: Emotion & Cognition Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, University Utrecht, P.O. Box 80151, Utrecht, The Netherlands; Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
authors.forename: Franz J
authors.initials: FJ
authors.lastname: van der Staay
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Science, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands. Electronic address: tim.vanmierlo@uhasselt.be.
authors.forename: Tim
authors.initials: T
authors.lastname: Vanmierlo
mesh_terms: D000818:Animals; D005260:Female; D011247:Pregnancy; D000493:Allopurinol / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D050882:CREB-Binding Protein / Q000378:metabolism; D004195:Disease Models, Animal; D000076122:Disks Large Homolog 4 Protein; D016166:Free Radical Scavengers / Q000633:toxicity; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology; D013552:Swine; D001724:Birth Weight; D000831:Animals, Newborn
chemical_list: D000493:Allopurinol; D019208:Brain-Derived Neurotrophic Factor; D050882:CREB-Binding Protein; D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; D016166:Free Radical Scavengers; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins
keywords: Allopurinol; BDNF; Low birth weight; Neuronal plasticity; Pig