title: Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.
abstract: OBJECTIVE
  Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.
  
  
  METHODS
  The study was carried out as a test-retest experiment in 20 healthy volunteers to examine the repeatability of the CBF and CBV estimates. All subjects were scanned twice with 7-20 days between investigations.
  
  
  RESULTS
  DSC-MRI returned an overestimated average whole-brain CBF of 220 ± 44 mL/100 g/min (mean ± SD) before correction and 44 ± 15 mL/100 g/min when applying the prebolus design, averaged over all scans. Average whole-brain CBV was 20 ± 2.0 mL/100 g before correction and 4.0 ± 1.0 mL/100 g after prebolus correction.
  
  
  CONCLUSIONS
  Quantitative estimates of CBF and CBV, obtained with the proposed prebolus DSC-MRI technique, approached those typically obtained by other perfusion modalities. The CBF and CBV estimates showed good repeatability.
authors.affiliation: Department of Medical Radiation Physics, Lund University, Lund, Sweden.
authors.forename: Linda
authors.initials: L
authors.lastname: Knutsson
authors.forename: Emelie
authors.initials: E
authors.lastname: Lindgren
authors.forename: André
authors.initials: A
authors.lastname: Ahlgren
authors.forename: Matthias J P
authors.initials: MJ
authors.lastname: van Osch
authors.forename: Karin Markenroth
authors.initials: KM
authors.lastname: Bloch
authors.forename: Yulia
authors.initials: Y
authors.lastname: Surova
authors.forename: Freddy
authors.initials: F
authors.lastname: Ståhlberg
authors.forename: Danielle
authors.initials: D
authors.lastname: van Westen
authors.forename: Ronnie
authors.initials: R
authors.lastname: Wirestam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology; D001811:Blood Volume Determination / Q000379:methods; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: cerebral blood flow; cerebral blood volume; dynamic susceptibility contrast MRI; perfusion; prebolus