title: Fetal alcohol spectrum disorders and childhood cancer: a concise review of case reports and future research considerations.
abstract: We reviewed the published literature on the relationship between childhood cancer and fetal alcohol spectrum disorders (FASD). A Pub Med search identified 12 subjects with the co-occurrence of FASD and cancer. We included an additional case from the author's institution. Neuroblastomas comprised 6 of the 13 (46%) case reports, yet neuroblastomas comprise only about 10% of childhood cancers (z = 4.1; P < 0.001). Other than rhabdomyosarcoma, no other cancer was reported more than once. Few cases of childhood cancer associated with FASD were identified likely due to under ascertainment of FASD.
authors.affiliation: Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota.
authors.forename: Larry
authors.initials: L
authors.lastname: Burd
authors.forename: Leah
authors.initials: L
authors.lastname: Peterson
authors.forename: Nathan
authors.initials: N
authors.lastname: Kobrinsky
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D035843:Biomedical Research; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology*; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D012196:Review Literature as Topic
keywords: alcohol; cancer; children; fetal alcohol spectrum disorders; pregnancy; prevalence