title: Protein kinase C, focal adhesions and the regulation of cell migration.
abstract: Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.
authors.affiliation: Department of Biomedical Sciences, University of Copenhagen, Denmark.
authors.forename: Betina S
authors.initials: BS
authors.lastname: Fogh
authors.forename: Hinke A B
authors.initials: HA
authors.lastname: Multhaupt
authors.forename: John R
authors.initials: JR
authors.lastname: Couchman
mesh_terms: D000818:Animals; D002465:Cell Movement; D004789:Enzyme Activation; D022001:Focal Adhesions; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D011493:Protein Kinase C
keywords: Adhesion; Cytoskeleton; Kinase; Microfilaments; Proteoglycan