title: Production of active oxygen species by blood phagocytes of pregnant women and their newborns with intrauterine infection.
abstract: We studied the relationship between changes in the maternal and newborn granulocyte functions under conditions of infection risk and realization. Women with normal gestation and their healthy newborns, pregnant women with a high risk of infection and their newborns, healthy or with intrauterine infection, were examined. Changes in the active oxygen species-dependent phagocytosis system were found in the blood of risk group patients. An inverse relationship between the parameters venous and umbilical cord blood was detected indicating a relationship between changes in functional activities of maternal and newborn granulocytes. The percentage of CD11b(+)cells in venous and umbilical cord blood strictly correlated with the percent of cells that phagocytosed FITC-labeled E. coli. Deviations in the generation of active oxygen species in phagocytosis seemed to be related to the expression of surface receptors in the risk groups.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino; V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. safronova@icb.psn.ru.
authors.forename: V G
authors.initials: VG
authors.lastname: Safronova
authors.forename: N K
authors.initials: NK
authors.lastname: Matveeva
authors.forename: N A
authors.initials: NA
authors.lastname: Lomova
authors.forename: A S
authors.initials: AS
authors.lastname: Belyaeva
authors.forename: L V
authors.initials: LV
authors.lastname: Vanko
mesh_terms: D000328:Adult; D039481:CD11b Antigen / Q000235:genetics / Q000276:immunology; D002585:Cesarean Section; D003141:Communicable Diseases / Q000097:blood* / Q000276:immunology / Q000473:pathology; D004926:Escherichia coli / Q000737:chemistry / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D058851:GPI-Linked Proteins / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D010587:Phagocytosis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D017382:Reactive Oxygen Species / Q000097:blood*; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology; D014599:Uterus / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019820:Xanthine / Q000097:blood; D019014:fas Receptor / Q000235:genetics / Q000276:immunology
chemical_list: D039481:CD11b Antigen; C491901:FAS protein, human; C428200:FCGR3B protein, human; D005456:Fluorescent Dyes; D058851:GPI-Linked Proteins; C509295:ITGAM protein, human; D017382:Reactive Oxygen Species; D017452:Receptors, IgG; D019014:fas Receptor; D019820:Xanthine; D016650:Fluorescein-5-isothiocyanate