title: Automatic classification of infant sleep based on instantaneous frequencies in a single-channel EEG signal.
abstract: This study presents a novel approach for the electroencephalogram (EEG) signal quantification in which the empirical mode decomposition method, a time-frequency method designated for nonlinear and non-stationary signals, decomposes the EEG signal into intrinsic mode functions (IMF) with corresponding frequency ranges that characterize the appropriate oscillatory modes embedded in the brain neural activity acquired using EEG. To calculate the instantaneous frequency of IMFs, an algorithm was developed using the Generalized Zero Crossing method. From the resulting frequencies, two different novel features were generated: the median instantaneous frequencies and the number of instantaneous frequency changes during a 30s segment for seven IMFs. The sleep stage classification for the daytime sleep of 20 healthy babies was determined using the Support Vector Machine classification algorithm. The results were evaluated using the cross-validation method to achieve an approximately 90% accuracy and with new examinee data to achieve 80% average accuracy of classification. The obtained results were higher than the human experts' agreement and were statistically significant, which positioned the method, based on the proposed features, as an efficient procedure for automatic sleep stage classification. The uniqueness of this study arises from newly proposed features of the time-frequency domain, which bind characteristics of the sleep signals to the oscillation modes of brain activity, reflecting the physical characteristics of sleep, and thus have the potential to highlight the congruency of twin pairs with potential implications for the genetic determination of sleep.
authors.affiliation: Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Split, R. Boškovića 32, 21000 Split, Croatia. Electronic address: maja@fesb.hr.
authors.forename: Maja
authors.initials: M
authors.lastname: Čić
authors.forename: Joško
authors.initials: J
authors.lastname: Šoda
authors.forename: Mirjana
authors.initials: M
authors.lastname: Bonković
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012815:Signal Processing, Computer-Assisted; D012894:Sleep Stages / Q000502:physiology*; D060388:Support Vector Machine
keywords: EEG quantification; Empirical Mode Decomposition (EMD); Generalized Zero Crossing (GZC); Intrinsic Mode Function (IMF); Sleep classification; Support Vector Machine (SVM)