title: Liver diseases in pregnancy: diseases not unique to pregnancy.
abstract: Pregnancy is a special clinical state with several normal physiological changes that influence body organs including the liver. Liver disease can cause significant morbidity and mortality in both pregnant women and their infants. Few challenges arise in reaching an accurate diagnosis in light of such physiological changes. Laboratory test results should be carefully interpreted and the knowledge of what normal changes to expect is prudent to avoid clinical misjudgment. Other challenges entail the methods of treatment and their safety for both the mother and the baby. This review summarizes liver diseases that are not unique to pregnancy. We focus on viral hepatitis and its mode of transmission, diagnosis, effect on the pregnancy, the mother, the infant, treatment, and breast-feeding. Autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, Wilson's disease, Budd Chiari and portal vein thrombosis in pregnancy are also discussed. Pregnancy is rare in patients with cirrhosis because of the metabolic and hormonal changes associated with cirrhosis. Variceal bleeding can happen in up to 38% of cirrhotic pregnant women. Management of portal hypertension during pregnancy is discussed. Pregnancy increases the pathogenicity leading to an increase in the rate of gallstones. We discuss some of the interventions for gallstones in pregnancy if symptoms arise. Finally, we provide an overview of some of the options in managing hepatic adenomas and hepatocellular carcinoma during pregnancy.
authors.affiliation: Ashraf A Almashhrawi, Khulood T Ahmed, Rubayat N Rahman, Ghassan M Hammoud, Jamal A Ibdah, Division of Gastroenterology and Hepatology, University of Missouri-Columbia, Columbia, MO 65212, United States.
authors.forename: Ashraf A
authors.initials: AA
authors.lastname: Almashhrawi
authors.forename: Khulood T
authors.initials: KT
authors.lastname: Ahmed
authors.forename: Rubayat N
authors.initials: RN
authors.lastname: Rahman
authors.forename: Ghassan M
authors.initials: GM
authors.lastname: Hammoud
authors.forename: Jamal A
authors.initials: JA
authors.lastname: Ibdah
mesh_terms: D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008107:Liver Diseases / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011379:Prognosis
keywords: Adenoma; Autoimmune; Cirrhosis; Gallstones; Liver; Pregnancy; Viral hepatitis