title: Highly specific enrichment of N-linked glycopeptides based on hydrazide functionalized soluble nanopolymers.
abstract: In this work, for the first time, hydrazide functionalized PAMAM was designed and synthesized for efficient and selective enrichment of N-linked glycopeptides from complex biological samples using FASP (filter-aided sample preparation) mode.
authors.affiliation: Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. luhaojie@fudan.edu.cn.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Hucong
authors.initials: H
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Yali
authors.initials: Y
authors.lastname: Wang
authors.forename: Caiyun
authors.initials: C
authors.lastname: Fang
authors.forename: Pengyuan
authors.initials: P
authors.lastname: Yang
authors.forename: Haojie
authors.initials: H
authors.lastname: Lu
mesh_terms: D000595:Amino Acid Sequence; D050091:Dendrimers / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006031:Glycosylation; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry; D043524:Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D050091:Dendrimers; D006020:Glycopeptides; C104700:PAMAM Starburst; D011108:Polymers; D043524:Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase