title: Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong.
abstract: Two new phthalides, chuanxiongdiolides A and B, were isolated from the roots of Ligusticum chuanxiong Hort. Their structures were established by UV, IR, 1D (¹H, ¹³C) and 2D (HSQC, ¹H-¹H COSY, HMBC, NOESY) NMR, and HR-ESI-MS methods, and their absolute configurations were assigned via circular dichroism exciton chirality. The two compounds showed different degrees of inhibitory effects against butyrylcholine esterase.
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Lu
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.forename: Guo-Yu
authors.initials: GY
authors.lastname: Li
authors.forename: Hang-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Li
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002091:Butyrylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D030004:Ligusticum / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D001572:Benzofurans; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; C586957:chuanxiongdiolide A; C586958:chuanxiongdiolide B; C082022:phthalide; D002091:Butyrylcholinesterase