title: Acadesine Triggers Non-apoptotic Death in Tumor Cells.
abstract: We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter Р-glycoprotein or lack of proapoptotic p53. Activity of adenosine receptors was required for acadesine-induced cell death, whereas functioning of АМР-dependent protein kinase was not required. A more pronounced cytotoxicity for tumor cells, as well as the non-canonical death mechanism(s), makes acadesine a promising candidate for antitumor therapy.
authors.affiliation: Blokhin Cancer Center, Russian Academy of Medical Sciences, 24, Kashirskoe shosse, Moscow, Russia, 115478.
authors.forename: V A
authors.initials: VA
authors.lastname: Glazunova
authors.forename: K V
authors.initials: KV
authors.lastname: Lobanov
authors.forename: R S
authors.initials: RS
authors.lastname: Shakulov
authors.forename: A S
authors.initials: AS
authors.lastname: Mironov
authors.forename: A A
authors.initials: AA
authors.lastname: Shtil
keywords: acadesine; cell death; tumor cells