title: Frailty: role of nutrition and exercise.
abstract: OBJECTIVE
  The scope of the current study is to provide an updated, comprehensive review of the recent literature (past 12 months), examining the role of nutrition and exercise on frailty.
  
  
  RESULTS
  Over the past 12 months, seven studies with different designs explored the relationship between nutrition and frailty, four examined the role of exercise on frailty, and only one study investigated the combination of the two interventions. The only study combining an exercise program with a nutritional consultation reported a short-term (3 months) improvement of the frailty status. Nevertheless, this study (a feasibility pilot trial) was characterized by a relatively small sample size, low response rates, and poor compliance. Notably, available evidence shows considerable variability in participants' selection, assessment methods, and outcomes of interest, so it is difficult to draw direct comparisons. Size effects or magnitude of associations across the different studies cannot also be determined.
  
  
  CONCLUSIONS
  The present findings suggest the need of long-term, adequately powered, randomized controlled trials testing nutrition, exercise or both interventions for the treatment of frailty in the elders. Such evidence will greatly support the future design of preventive strategies against disability in older persons.
authors.affiliation: aGérontopôle, Centre Hospitalier Universitaire de Toulouse bINSERM UMR 1027 cUniversité de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Eirini
authors.initials: E
authors.lastname: Kelaiditi
authors.forename: Gabor Abellan
authors.initials: GA
authors.lastname: van Kan
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
mesh_terms: D000368:Aged; D015444:Exercise; D016330:Frail Elderly; D006801:Humans; D009752:Nutritional Status; D064887:Observational Studies as Topic; D016032:Randomized Controlled Trials as Topic