title: Functional activity of varicose human great saphenous vein at different sites.
abstract: Experiments on isolated preparations of varicose human great saphenous vein revealed different sensitivity of the distal and proximal portions to P2X receptor agonist α,β-methylene-ATP, but not to norepinephrine and histamine. It is suggested that restructuring of the P2 receptor system plays an important role in the pathogenesis of varicose veins, which affects the trunk of the great saphenous vein in varying degrees.
authors.forename: B A
authors.initials: BA
authors.lastname: Ziganshin
authors.forename: D A
authors.initials: DA
authors.lastname: Slavin
authors.forename: A P
authors.initials: AP
authors.lastname: Ziganshina
authors.forename: R K
authors.initials: RK
authors.lastname: Dzhordzhikiya
authors.forename: A U
authors.initials: AU
authors.lastname: Ziganshin
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D017442:Histamine Agonists / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology; D058910:Purinergic P2 Receptor Agonists / Q000494:pharmacology; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D012501:Saphenous Vein / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D014648:Varicose Veins / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D017442:Histamine Agonists; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2; D014662:Vasoconstrictor Agents; D006632:Histamine; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D009638:Norepinephrine