title: Potentially simple score of late gadolinium enhancement cardiac MR in acute myocarditis outcome.
abstract: OBJECTIVE
  To determine the value of cardiac MRI for the monitoring and the prognosis of patients with acute myocarditis. Cardiac MRI plays an increasingly important role in the diagnosis of acute myocarditis. However, it is less established as a prognostic tool, which requires specific postprocessing of images.
  
  
  METHODS
  In a prospective pilot study, we assessed the prognostic value of the evolution in a simplified visual quantitative score (SQS) of late gadolinium enhancement (LGE) between initial hospitalization and 3 months later. The prognostic value was assessed at 1 year using a combination of death, heart transplant, and confirmed recurrence as main outcome.
  
  
  RESULTS
  Twenty-eight patients were included in this study. A significant correlation was found between LGE measured by SQS and planimetry (r = 0.95, P < 0.001). Intraobserver and interobserver reproducibilities were good for SQS (ICC = 0.95 [95% CI: 0.86 to 0.98], and 0.94 [95% CI: 0.84 to 0.98], respectively). At initial hospitalization, patient characteristics between the two groups were similar. Patients with stable or increased SQS suffered more frequently from clinical outcome events than patients with a decrease in SQS (P = 0.02).
  
  
  CONCLUSIONS
  Monitoring of the evolution of LGE using a simple visual score is of interest to identify patients at risk of pejorative prognosis after acute myocarditis.
authors.affiliation: Department of Cardiology, University Hospital, Grenoble, France; INSERM U 1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Barone-Rochette
authors.forename: Caroline
authors.initials: C
authors.lastname: Augier
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rodière
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Quesada
authors.forename: Alison
authors.initials: A
authors.lastname: Foote
authors.forename: Hélène
authors.initials: H
authors.lastname: Bouvaist
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Marlière
authors.forename: Daniel
authors.initials: D
authors.lastname: Fagret
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Baguet
authors.forename: Gérald
authors.initials: G
authors.lastname: Vanzetto
mesh_terms: D000208:Acute Disease; D000465:Algorithms; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008536:Meglumine; D009205:Myocarditis / Q000473:pathology* / Q000628:therapy*; D009942:Organometallic Compounds; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
keywords: cardiac magnetic resonance; delayed gadolinium-enhancement; myocarditis; prognosis