title: [Aging and inflammation: Klotho, diet and the kidney connection].
abstract: Despite renal replacement therapy mortality among chronic kidney disease patients is 10-1000-fold higher than in age-matched controls. Klotho is a kidney protein with anti-ageing hormonal properties that is also a co-receptor for the FGF23 fosfatonin. There is a bidirectional relationship between Klotho and inflammation. Thus, inflammation decreases renal Klotho and Klotho has anti-inflammatory properties. Mice with genetic defects in Klotho suffer from accelerated aging and early death. Decreasing the phosphate load improves the phenotype and prolongs survival in these mice. Unraveling the Klotho-phosphate-inflammation interaction may open new avenues for research that may improve the outcomes of kidney patients as well as provide new tools to retard aging in the general population.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz Arduan
mesh_terms: D000375:Aging; D000818:Animals; D004032:Diet; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D000090265:Klotho Proteins; D051379:Mice; D051436:Renal Insufficiency, Chronic / Q000209:etiology*
chemical_list: C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins