title: Splenectomy complicated by sustained extreme thrombocytosis and extensive portosplenomesenteric vein thrombosis in pyrimidine 5'-nucleotidase deficiency.
abstract: Reactive and redistributional thrombocytosis is a well-known postsplenectomy occurrence .Usually it is transient and it rarely reaches extreme levels. We report a rare case of haemolytic anaemia where splenectomy was carried out following trauma to a massively enlarged spleen and was followed by extreme sustained thrombocytosis associated with extensive portal, splenic and mesenteric vein thrombosis despite standard antithrombotic prophylaxis.
authors.affiliation: Department of Haematology, Amiri Hospital, Kuwait City, Kuwait.
authors.forename: Hassan A
authors.initials: HA
authors.lastname: Al-Jafar
authors.forename: Ali
authors.initials: A
authors.lastname: Taqi
authors.forename: John Patrick
authors.initials: JP
authors.lastname: Madda
authors.forename: Thamer A
authors.initials: TA
authors.lastname: Abdullah
mesh_terms: D015720:5'-Nucleotidase / Q000172:deficiency* / Q000235:genetics; D000745:Anemia, Hemolytic, Congenital / Q000150:complications* / Q000235:genetics / Q000473:pathology; D000925:Anticoagulants / Q000008:administration & dosage; D000963:Antimetabolites / Q000008:administration & dosage; D005260:Female; D006801:Humans; D011169:Portal Vein / Q000473:pathology*; D013156:Splenectomy / Q000009:adverse effects*; D013922:Thrombocytosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D000963:Antimetabolites; D015720:5'-Nucleotidase