title: Small molecules: an overview of emerging therapeutic options in the treatment of psoriasis.
abstract: Psoriasis is a chronic condition which requires ongoing management with therapies that have demonstrated favorable safety and efficacy profiles in long-term use. While biologics changed the way psoriasis is treated by providing effective targeted therapy, they are not without limitations. However, small molecules are emerging therapeutic options for the treatment of psoriasis. Several oral and topical small molecules, spanning different therapeutic classes, are proving to be promising treatment options in psoriasis. While studies to date have yielded positive results, further investigation of these agents are warranted for both safety and efficacy.
authors.affiliation: Skin Centre for Dermatology, Peterborough, ON, Canada.
authors.forename: Melinda
authors.initials: M
authors.lastname: Gooderham
mesh_terms: D005650:Fumarates / Q000627:therapeutic use; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors*; D058988:Phosphodiesterase 4 Inhibitors / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*; D049349:Receptors, Lysosphingolipid / Q000819:agonists*
chemical_list: D005650:Fumarates; D058988:Phosphodiesterase 4 Inhibitors; D049349:Receptors, Lysosphingolipid; D053612:Janus Kinases