title: Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata.
abstract: This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3″. This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 µM, which was associated with the medicinal functions of H. cordata.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, People's Republic of China.
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Chen
authors.affiliation: State Key Laboratory for Respiratory Disease, Laboratory of Viral Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.affiliation: State Key Laboratory for Respiratory Disease, Laboratory of Viral Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
authors.forename: Qin-Chang
authors.initials: QC
authors.lastname: Zhu
authors.affiliation: The second clinical college of Guangzhou university of Chinese medicine, Guangzhou, People's Republic of China.
authors.forename: Chuan-Jian
authors.initials: CJ
authors.lastname: Lu
authors.affiliation: State Key Laboratory for Respiratory Disease, Laboratory of Viral Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wu
authors.affiliation: State Key Laboratory for Respiratory Disease, Laboratory of Viral Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, People's Republic of China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002681:China; D002522:Chlorocebus aethiops; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D052859:Houttuynia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal; D014709:Vero Cells
chemical_list: D000447:Aldehydes; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C023969:decanoyl acetaldehyde