title: The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses.
abstract: Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Frederic
authors.initials: F
authors.lastname: Vigant
authors.forename: Axel
authors.initials: A
authors.lastname: Hollmann
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Nuno C
authors.initials: NC
authors.lastname: Santos
authors.forename: Michael E
authors.initials: ME
authors.lastname: Jung
authors.forename: Benhur
authors.initials: B
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000528:radiation effects / Q000821:virology; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000235:genetics / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008027:Light; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents