title: SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE.
abstract: We report an integrated nanochannel/nanoelectrode sensor for the detection of DNA using alternating currents. We find that DNA can be detected using platinum as the metal for the detecting electrodes, with a signal to noise ratio exceeding 10. We argue that the signal is at least in part electrochemical in nature, thus holds the promise to yield a sequence-dependent signal. However, we also find that for large voltages, DNA attaches irreversibly to the driving electrodes.
authors.affiliation: Department of Physics, North Carolina State University Campus Box 8202, Raleigh, NC 27695, USA.
authors.forename: Bret H
authors.initials: BH
authors.lastname: Davis
authors.forename: Junhan
authors.initials: J
authors.lastname: Pan
authors.forename: Chih-Kuan
authors.initials: CK
authors.lastname: Tung
authors.forename: Robert H
authors.initials: RH
authors.lastname: Austin
authors.forename: Robert
authors.initials: R
authors.lastname: Riehn
keywords: DNA sequencing; nanochannels; nanoelectrodes