title: In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconverison nanoparticles.
abstract: Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and NIR-activated platinum pro-drug delivery. We use the core-shell structured upconversion nanoparticles to convert the absorbed NIR light into UV to activate the trans-platinum(IV) pro-drug, trans,trans,trans-[Pt(N3)2(NH3)(py)(O2CCH2CH2COOH)2]. Compared with using the UV directly, the NIR has a higher tissue penetration depth and is less harmful to health. Meanwhile, the upconversion nanoparticles can effectively deliver the platinum(IV) pro-drugs into the cells by endocytosis. The mice treated with pro-drug-conjugated nanoparticles under near-infrared (NIR) irradiation demonstrated better inhibition of tumor growth than that under direct UV irradiation. This multifunctional nanocomposite could be used as multimodality bioimaging contrast agents and transducers by converting NIR light into UV for control of drug activity in practical cancer therapy.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, 130022, People's Republic of China.
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Yuan
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Hou
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D046529:Microscopy, Electron, Transmission; D064847:Multimodal Imaging; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D010984:Platinum / Q000008:administration & dosage*; D011355:Prodrugs / Q000008:administration & dosage*; D013056:Spectrophotometry, Ultraviolet; D014057:Tomography, X-Ray Computed
chemical_list: D011355:Prodrugs; D010984:Platinum