title: While waiting: early recognition and initial management of neonatal hypoxic-ischemic encephalopathy.
abstract: Hypoxic-ischemic encephalopathy (HIE) occurring during the perinatal period is one of the primary causes of severe, long-term neurological deficits in children. Initial systemic supportive therapy remains a critical aspect of HIE management. In addition to support therapy, the widespread use of hypothermia has demonstrated a reduction in death and neurodevelopmental disability in infants with moderate to severe HIE. Neonates with HIE born outside of tertiary care centers must be rapidly identified as hypothermia candidates and have emergent transport arranged. While waiting for the transport team to arrive, these neonates often require intensive stabilization, including meticulous temperature management. This article examines the need for HIE outreach teaching programs, assists in the identification of a neonate for hypothermia therapy, and supplies evidence-based recommendations for the initial stabilization and care of neonates delivered at nontertiary care facilities. The guidelines and materials supplied represent the outreach model used by our regional hypothermia center and disseminated to the surrounding referral hospitals.
authors.affiliation: Department of Pediatrics, Division of Neonatology, University of Florida, Jacksonville (Dr Sussman); and Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville (Dr Weiss).
authors.forename: Craig B
authors.initials: CB
authors.lastname: Sussman
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiss
mesh_terms: D000138:Acidosis / Q000150:complications / Q000628:therapy; D042241:Early Diagnosis; D061345:Early Medical Intervention; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000628:therapy; D015931:Intensive Care, Neonatal / Q000379:methods*; D010360:Patient Transfer / Q000379:methods*; D012017:Referral and Consultation; D012640:Seizures / Q000150:complications / Q000628:therapy; D018805:Sepsis / Q000150:complications / Q000628:therapy; D062606:Tertiary Care Centers; D014187:Transportation of Patients; D016896:Treatment Outcome