title: Effects of multiwalled carbon nanotubes received orally during 6 days on the gastrointestinal tract.
abstract: The effects of multiwalled carbon nanotubes on epitheliocytes of different compartments of the gastrointestinal tract and urothelium of different compartments of the renal nephron were studied in CBA mice. The nanotubes affected mouse gastrointestinal mucosa and renal urothelium. The cell reaction in the macula densa of the renal distal tubules and the immune system reaction to oral nanotubes were detected. A possible effect of nanotubes administered orally on the renal filtration function was hypothesized.
authors.affiliation: Far-Eastern Federal University, Vladivostok; Vladivostok Affiliated Department of Far-Eastern Center of Respiratory Pathology and Physiology, Siberian Division of the Russian Academy of Medical Sciences, Institute of Medical Climatology and Rehabilitative Treatment; G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences, Novosibirsk; G. B. Elyakov Pacific Institute of Organic Biochemistry, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia. RevaGal@yandex.ru.
authors.forename: K S
authors.initials: KS
authors.lastname: Golokhvast
authors.forename: V V
authors.initials: VV
authors.lastname: Chaika
authors.forename: L V
authors.initials: LV
authors.lastname: Kuznetsov
authors.forename: K V
authors.initials: KV
authors.lastname: Elumeeva
authors.forename: M I
authors.initials: MI
authors.lastname: Kusaikin
authors.forename: A M
authors.initials: AM
authors.lastname: Zakharenko
authors.forename: N N
authors.initials: NN
authors.lastname: Kiselev
authors.forename: A M
authors.initials: AM
authors.lastname: Panichev
authors.forename: G V
authors.initials: GV
authors.lastname: Reva
authors.forename: V V
authors.initials: VV
authors.lastname: Usov
authors.forename: I V
authors.initials: IV
authors.lastname: Reva
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: A N
authors.initials: AN
authors.lastname: Gul'kov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000378:metabolism / Q000633:toxicity*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000187:drug effects; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D037742:Nanotubes, Carbon / Q000633:toxicity*; D019459:Urothelium / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D037742:Nanotubes, Carbon