title: [World of functional RNA].
abstract: The development of next-generation sequences has brought not only high-throughput sequencing but also new possibilities for various kinds of analysis methods of genetic information. Dr. Hayashizaki et al. developed new technologies to construct the full-length cDNA library and applied them to high-throughput sequencing technologies for large-scale transcriptome analysis. These analysis results overturned the conventional assumption the 2% of the genome is transcribed by showing that 70% or more of the genome is transcribed as RNA through FANTOM activities which was founded in 2000 on their initiative. Further, the existence of 23,000 non-protein coding RNAs was confirmed. These new findings redefine the central dogma into a new picture containing new interaction cascade and the unexpected complexity of combined omics. The neo central dogma shows that there are three types of final products derived from genes; long ncRNA, small ncRNA, and protein. They play essential roles by forming complexes with each other to maintain life. Long ncRNA and small ncRNA play a role as a ligand with sequence information. Long ncRNA and protein play a role as a functional molecule. Here, I would like to introduce the neo central dogma concept and some of the mechanisms of ncRNAs.
authors.affiliation: Preventive Medicine and Diagnosis Innovation Program, RIKEN Research Cluster for Innovation.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Okada
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends; D015723:Gene Library; D015894:Genome, Human / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods* / Q000639:trends; D006801:Humans; D012313:RNA / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000502:physiology; D022661:RNA, Untranslated / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012313:RNA