title: Evidence for brain activation in patients with takotsubo cardiomyopathy.
abstract: BACKGROUND
  It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy.
  
  
  RESULTS
  We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using (99m)Tc ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion.
  
  
  CONCLUSIONS
  These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.
authors.affiliation: Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sugimura
authors.forename: Jun
authors.initials: J
authors.lastname: Takahashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: Shoki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
mesh_terms: D001921:Brain / Q000098:blood supply*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon