title: [Α-synuclein as a biomarker for early diagnosis of Parkinsonism].
abstract: Although α-synuclein protein (αS) aggregates from a monomer to assemblies such as oligomer, protofibril and mature fibril, the early intermediate aggregate, that is, oligomer has been considered to be most toxic species in recent reports. While it was reported that αS concentration in cerebrospinal fluid was decreased significantly in the patients with Parkinson's disease (PD) and dementia with Lewy bodies, there were reports that αS oligomer concentration was elevated in cerebrospinal fluid of PD patients. Moreover, it was supposed that αS oligomer concentration was also elevated in blood of PD patients. Further studies of αS in cerebrospinal fluid and blood would lead to establishment of the significance of αS as a biomarker for α-synucleinopathies including PD.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ono
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D042241:Early Diagnosis; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis; D020734:Parkinsonian Disorders / Q000175:diagnosis*; D066329:Protein Aggregates; D066263:Protein Aggregation, Pathological; D051844:alpha-Synuclein / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D066329:Protein Aggregates; D051844:alpha-Synuclein