title: New alkaloids from Aconitum taipaicum and their cytotoxic activities.
abstract: Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.
authors.affiliation: a Faculty of Pharmacy, Medical College of Xi'an Jiaotong University , Xi'an 710061 , P.R. China.
authors.forename: Zeng-Jun
authors.initials: ZJ
authors.lastname: Guo
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Meng-Yi
authors.initials: MY
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Xi
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031841:Aconitum / Q000737:chemistry*; D000465:Algorithms; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004317:Doxorubicin; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C000591035:taipeinine A; C000591036:taipeinine B; C000591038:taipeinine C; D004317:Doxorubicin; D000157:Aconitine