title: MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy.
abstract: BACKGROUND
  MicroRNAs (miRNAs) are a group of noncoding RNAs,∼ 20 - 22 nucleotides in length, that repress target gene expression through mRNA degradation and translation inhibition. The gene encoding miR-323-3p, which is a biomarker in immune and inflammatory responses, exists in a miRNA cluster in chromosomal region 14q32.31. It has been shown that miR-323-3p associates with the pathogenesis of several diseases, such as rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy.
  
  
  METHODS
  This review provides a current view on the association of miR-323-3p with several human diseases and is focused on the recent studies of miR-323-3p regulation, discussing its potential as an epigenetic biomarker and therapeutic target for these diseases. In particular, the mechanisms of miR-323-3p in these diseases and how miR-323-3p is regulated are also discussed.
  
  
  CONCLUSIONS
  Although the exact role of miR-323-3p in these diseases has not been fully elucidated, targeting miR-323-3p may serve as a promising therapy strategy.
authors.affiliation: Anhui Medical University, School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products , Anhui Province, 81 Meishan Road, Hefei 230032 , China +86 551 65161001 ; +86 551 65161001 ; lj@ahmu.edu.cn , ahmuxutao@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Peng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D060825:Cognitive Dysfunction / Q000235:genetics*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics*
chemical_list: C573188:MIRN323 microRNA, human; D035683:MicroRNAs