title: [Esophageal papilloma: case report, molecular identification of human papillomavirus and literature review].
abstract: sophageal squamous papilloma is an uncommon, usually asymptomatic, benign tumor of the squamous epithelium consisting of a raised, sessile, small and round (smooth or rough) lesion. The prevalence is between 0.01 and 0.45% of cases, with a male/female ratio of 3:1. The etiology and pathogenesis appear to be a mechanical or chemical irritation of the mucosa in addition to the presence of human papillomavirus (HPV), important agent in the evolution to a squamous carcinoma, especially HPV types 16 and 18. In this paper, we describe a case of esophageal papilloma whose diagnosis involved endoscopic images, pathological studies and detection of viral DNA by polymerase chain reaction. By using molecular techniques (PCR-RFLP) a profile consistent with HPV type 16 has been obtained. The patient underwent polypectomy and currently, after 3 years of diagnosis, he remains asymptomatic. This work is one of the first national reports of a patient with esophageal papilloma in which one of the most frequently HPV genotypes associated with esophageal carcinoma (HPV 16) has been detected.
authors.affiliation: Servicio de Gastroenterología, Hospital Dr J M Cullen, Santa Fe, Argentina. yanina4381@hotmail.com
authors.forename: Yanina
authors.initials: Y
authors.lastname: Barbaglia
authors.forename: Félix
authors.initials: F
authors.lastname: Jiménez
authors.forename: Fabián
authors.initials: F
authors.lastname: Tedeschi
authors.forename: Fabián
authors.initials: F
authors.lastname: Zalazar
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000821:virology*; D052162:Human papillomavirus 16 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D010212:Papilloma / Q000473:pathology / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral