title: The duodenal-jejunal bypass liner for the treatment of type 2 diabetes mellitus and/or obesity: a systematic review.
abstract: This systematic literature review applies the GRADE approach to evaluate the efficacy and safety of the duodenal-jejunal bypass liner (DJBL) for the treatment of (a) patients with obesity ≥ grade II (with comorbidities) and (b) patients with type 2 diabetes mellitus + obesity ≥ grade I. We included ten studies with a total of 342 patients that primarily investigated a prototype of the DJBL. In high-grade obese patients, short-term excess weight loss was observed. For the remaining patient-relevant endpoints and patient populations, evidence was either not available or ambiguous. Complications (mostly minor) occurred in 64-100% of DJBL patients compared to 0-27% in the control groups. Gastrointestinal bleeding was observed in 4% of patients. We do not yet recommend the device for routine use.
authors.affiliation: Department of "Health Economics", Ludwig Boltzmann Institute for Health Technology Assessment, Garnisongasse 7/20, 1090, Vienna, Austria, ingrid.zechmeister@hta.lbg.ac.at.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Zechmeister-Koss
authors.forename: Mirjana
authors.initials: M
authors.lastname: Huić
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
mesh_terms: D050110:Bariatric Surgery / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000150:complications / Q000601:surgery*; D012074:Remission Induction; D016896:Treatment Outcome; D015431:Weight Loss