title: Study of hepatoprotective effects of xymedon.
abstract: Xymedon (1-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine), a regeneratory and wound-healing drug, exhibited hepatoprotective activity in laboratory animals with experimental toxic hepatitis. Oral drug reduced the severity of toxic involvement of the liver induced by CCl4 and reduced animal mortality. Xymedon promoted recovery of the blood biochemical parameters characterizing the liver status.
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences; Kazan (Volga Region) Federal University, Russia. eugene@kndvor.ru.
authors.forename: A B
authors.initials: AB
authors.lastname: Vyshtakalyuk
authors.forename: N G
authors.initials: NG
authors.lastname: Nazarov
authors.forename: I V
authors.initials: IV
authors.lastname: Zueva
authors.forename: A V
authors.initials: AV
authors.lastname: Lantsova
authors.forename: O A
authors.initials: OA
authors.lastname: Minnekhanova
authors.forename: D V
authors.initials: DV
authors.lastname: Busygin
authors.forename: A G
authors.initials: AG
authors.lastname: Porfiryev
authors.forename: V G
authors.initials: VG
authors.lastname: Evtyugin
authors.forename: V S
authors.initials: VS
authors.lastname: Reznik
authors.forename: V V
authors.initials: VV
authors.lastname: Zobov
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D021461:Animals, Outbred Strains; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats
chemical_list: D001786:Blood Glucose; D020011:Protective Agents; D011743:Pyrimidines; C069705:xymedon; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase