title: Endometrial stromal sarcoma arising in vagina.
abstract: Endometrial stromal sarcoma (ESS) arising in the vagina is an extremely rare extrauterine endometrial stroma sarcoma, with only 4 cases reported in the literature up to date. Here we report a case of neoplasm originating from vagina. A 32-year-old woman complained of intermittent vaginal bleeding especially after intercourse. A mass with a diameter of 1.0 cm was found in the middle and upper segments of the right posterior vaginal wall. Biopsy showed ESS. Total abdominal hysterectomy, unilateral salpingo-oophorectomy (right) and partial vaginectomy were performed. No ESS lesion was found in endometrium. The patient received six courses of platinum-containing combination chemotherapy after surgery and was free of tumor 18 months after the diagnosis of ESS. The diagnosis of ESS relies on pathologic examination. CD10 is the most useful immunohistochemical marker for the diagnosis of this tumor. The mainstay treatment of ESS is surgery. Local excision and ovarian retaining may be considered in premenopausal women.
authors.affiliation: Medical College of Nanchang University Nanchang, Jiangxi, China ; Department of Gynecology, Nanshan Affiliated Hospital of Guangdong Medical College Shenzhen, Guangdong, China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Liu
authors.forename: Jiao
authors.initials: J
authors.lastname: Ding
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Kehan
authors.initials: K
authors.lastname: Yu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007150:Immunohistochemistry; D018203:Sarcoma, Endometrial Stromal / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor
keywords: Extrauterine sarcoma; endometrial stromal; immunohistochemistry; vagina