title: Diverse roles of natural killer T lymphocytes in liver and spleen in mice with experimental autoimmune uveitis.
abstract: Natural killer T lymphocytes (NKT cells) have diverse roles in different organs. However, it is still unclear whether NKT cells play different roles in the liver and spleen in mice with experimental autoimmune uveitis. In the present study, we explored their diverse roles of NKT cells in the liver and spleen and found that liver-derived NKT cells could efficiently inhibit Th1 and Th17 differentiation, whereas the function of spleen-derived NKT cells was less potent. Meanwhile, the occurrence of the peak ratios of NKT cells/T cells in the spleen and liver was markedly asynchronous after immunization. Moreover, different methods of immunization could result in different immune responses in mice. Furthermore, the memory response was also found in the generation of NKT cells in mice when they received the same antigen. These results indicate that the functional roles of NKT cells possess diversity in the spleen and liver in mice with experimental autoimmune uveitis.
authors.affiliation: Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan, 250002, China.
authors.forename: Shengya
authors.initials: S
authors.lastname: Zhao
authors.forename: Dadong
authors.initials: D
authors.lastname: Guo
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Bi
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Xie
authors.forename: Xingrong
authors.initials: X
authors.lastname: Wang
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002450:Cell Communication; D002454:Cell Differentiation; D002478:Cells, Cultured; D018920:Coculture Techniques; D004195:Disease Models, Animal; D005136:Eye Proteins; D005260:Female; D007156:Immunologic Memory; D008099:Liver / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells / Q000276:immunology* / Q000378:metabolism; D010446:Peptide Fragments; D012177:Retinol-Binding Proteins; D013154:Spleen / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D013997:Time Factors; D014605:Uveitis / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D000099214:Retinol-Binding Proteins, Interstitial
chemical_list: D015415:Biomarkers; D005136:Eye Proteins; D010446:Peptide Fragments; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial