title: An efficient laboratory-scale preparative method for [1-(13)C]glycocholic acid.
abstract: A breath test using [1-(13)C]glycocholic acid as a substrate is a potential diagnostic method for small intestinal bacterial overgrowth syndrome. [1-(13)C]Glycocholic acid has been thus synthesized in an excellent yield from ethyl [1-(13)C]glycinate hydrochloride in a one-pot reaction. This method is suitable for the preparation of the labeled compound on a laboratory scale, which helps to perform extensive clinical studies of the breath test.
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime, 790-8578, Japan.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
authors.forename: Naoko
authors.initials: N
authors.lastname: Tokumasu
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tando
authors.forename: Teruo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Kazuki
authors.initials: K
authors.lastname: Akira
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D006000:Glycocholic Acid / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D006000:Glycocholic Acid
keywords: breath test; carbon-13; glycocholic acid; laboratory scale; one-pot reaction; stable labeled synthesis