title: Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes.
abstract: We describe three cases of J-wave syndrome in which ventricular fibrillation (VF) was probably induced by corticosteroid therapy. The patients involved were being treated with prednisolone for concomitant bronchial asthma. One of the three patients had only one episode of VF during her long follow-up period (14 years). Two patients had hypokalemia during their VF episodes. Corticosteroids have been shown to induce various types of arrhythmia and to modify cardiac potassium channels. We discuss the possible association between corticosteroid therapy and VF in J-wave syndrome based on the cases we have encountered.
authors.affiliation: Department of Cardiology, Asahikawa Medical University, Midorigaoka Higashi 2-1-1, Asahikawa, 078-8510, Japan.
authors.forename: Naka
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Masahide
authors.initials: M
authors.lastname: Goto
authors.forename: Motoi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takehara
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Ahmed Karim
authors.initials: AK
authors.lastname: Talib
authors.forename: Eitaro
authors.initials: E
authors.lastname: Sugiyama
authors.forename: Akiho
authors.initials: A
authors.lastname: Minoshima
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Kazumi
authors.initials: K
authors.lastname: Akasaka
authors.forename: Junichi
authors.initials: J
authors.lastname: Kawabe
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Doi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis; D008297:Male; D013577:Syndrome; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D005938:Glucocorticoids