title: Multiple Marjolin's ulcers arising from irradiated post-burn hypertrophic scars: a case report.
abstract: Marjolin's ulcer is an aggressive ulcerating cutaneous malignancy that may arise in chronically inflamed or traumatized skin. Frequently overlooked, this rare condition is classically associated with burn scars, with the process of malignant degeneration typically occurring over two to three decades. The most common histopathological pattern is squamous cell carcinoma; however, compared to typical squamous cell carcinomas, Marjolin's ulcers have an increased rate of metastasis. The correlation between radiotherapy for benign hypertrophic scarring and carcinogenesis is controversial, with few reports in the literature. We present a unique case of a 61 year old Caucasian male who was burned by scald at age 4, received radiotherapy for his post-burn hypertrophic scars, and later developed multiple Marjolin's ulcers on his left arm, chest, and right temporal scalp.
authors.affiliation: Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, Division of Critical Care Medicine, Firefighters' Burn Treatment Unit, Canada.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Zuo
authors.affiliation: Department of Surgery, University of Alberta, 2D2.28 WMC, 8440-112 Street, Edmonton, Alberta T6G 2B7, Canada. Electronic address: etredget@ualberta.ca.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Tredget
mesh_terms: D002056:Burns / Q000150:complications*; D002280:Basal Cell Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000532:radiotherapy*; D005543:Forearm Injuries / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D012883:Skin Ulcer / Q000150:complications / Q000175:diagnosis* / Q000601:surgery