title: Carbon-14 labeling of K777•HCl, a therapeutic agent for Chagas disease.
abstract: The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [(14) C(U)]-(l)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%.
authors.affiliation: SRI International, Biosciences Division, 333-Ravenswood Ave, Menlo Park, CA, 94025, USA.
authors.forename: Sung-Whi
authors.initials: SW
authors.lastname: Rhee
authors.forename: Wallace W
authors.initials: WW
authors.lastname: Bradford
authors.forename: Jeremiah P
authors.initials: JP
authors.lastname: Malerich
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Tanga
mesh_terms: D000042:Absorption; D002250:Carbon Radioisotopes / Q000737:chemistry / Q000627:therapeutic use; D014355:Chagas Disease / Q000532:radiotherapy*; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D055808:Drug Discovery; D007553:Isotope Labeling; D010649:Phenylalanine / Q000031:analogs & derivatives; D010879:Piperazines; D014105:Tosyl Compounds; D014753:Vinyl Compounds / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D002250:Carbon Radioisotopes; D004151:Dipeptides; D010879:Piperazines; D014105:Tosyl Compounds; D014753:Vinyl Compounds; C487484:N-pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl; D010649:Phenylalanine
keywords: Chagas disease; K777; Trypanosoma cruzi; vinyl sulfone