title: Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.
abstract: The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA, sgrayson@tulane.edu.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Grayson
authors.forename: Brittany K
authors.initials: BK
authors.lastname: Myers
authors.forename: Jonas
authors.initials: J
authors.lastname: Bengtsson
authors.forename: Michael
authors.initials: M
authors.lastname: Malkoch
mesh_terms: D002138:Calibration / Q000592:standards; D050091:Dendrimers / Q000737:chemistry*; D008958:Models, Molecular; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D012015:Reference Standards; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000592:standards*
chemical_list: D050091:Dendrimers; D011091:Polyesters