title: Galaxy High Throughput Genotyping Pipeline for GeneTitan.
abstract: Latest genotyping solutions allow for rapid testing of more than two million markers in one experiment. Fully automated instruments such as Affymetrix GeneTitan enable processing of large numbers of samples in a truly high-throughput manner. In concert with solutions like Axiom, fully customizable array plates can now utilize automated workflows that can leverage multi-channel instrumentation like the GeneTitan. With the growing size of raw data output, the serial computational architecture of the software, typically distributed by the vendors on turnkey desktop solutions for quality control and genotype calling, becomes legacy rather than an advantage. Advanced software techniques provide power, flexibility, and can be deployed in an HPC environment, but become technically inconvenient for biologists to use. Here we present a pipeline that uses Galaxy as a mechanism to lower the barrier for complex analysis, and increase efficiency by leveraging high-throughput computing.
authors.affiliation: University of Illinois at Chicago, Chicago, IL.
authors.forename: Oleksiy
authors.initials: O
authors.lastname: Karpenko
authors.forename: Neil
authors.initials: N
authors.lastname: Bahroos
authors.forename: Morris
authors.initials: M
authors.lastname: Chukhman
authors.forename: Xiao
authors.initials: X
authors.lastname: Dong
authors.forename: Pinal
authors.initials: P
authors.lastname: Kanabar
authors.forename: Zarema
authors.initials: Z
authors.lastname: Arbieva
authors.forename: Tommie
authors.initials: T
authors.lastname: Jackson
authors.forename: William
authors.initials: W
authors.lastname: Hendrickson