title: Oxime ligation: a chemoselective click-type reaction for accessing multifunctional biomolecular constructs.
abstract: There is a growing need for biocompatible click reactions in order to prepare multifunctional conjugates, which are valuable molecules for innovative biomedical applications. In this context, we review the recent advances in the implementation of oxime ligation for the synthesis of multivalent or multicomponent systems. The value of these products is emphasized by their use in cell targeting, imaging, synthetic vaccines, and surface modifications.
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, Ecole Nationale Supérieure de Chimie de Montpellier, 8 Rue de l'Ecole Normale, 34296 Montpellier cedex 5 (France), Fax: (+33) 467144353.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ulrich
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
authors.forename: Alberto
authors.initials: A
authors.lastname: Marra
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
mesh_terms: D000818:Animals; D057930:Click Chemistry; D020738:Leptin / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology; D009389:Neovascularization, Pathologic; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology
chemical_list: D020738:Leptin; D010091:Oximes; D014614:Vaccines, Synthetic
keywords: bioconjugation; biomolecular recognition; chemoselectivity; multivalency; oxime