title: Evaluation of elevated urinary enolase I levels in patients with endometriosis.
abstract: OBJECTIVE
  The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis.
  
  
  METHODS
  Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine.
  
  
  RESULTS
  Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively.
  
  
  CONCLUSIONS
  Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine , Seoul , Republic of Korea .
authors.forename: Bo Hyon
authors.initials: BH
authors.lastname: Yun
authors.forename: You Sun
authors.initials: YS
authors.lastname: Lee
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Chon
authors.forename: Yeon Soo
authors.initials: YS
authors.lastname: Jung
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Yim
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Seok Kyo
authors.initials: SK
authors.lastname: Seo
authors.forename: SiHyun
authors.initials: S
authors.lastname: Cho
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D014408:Biomarkers, Tumor / Q000652:urine*; D018394:CA-125 Antigen / Q000097:blood; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D004268:DNA-Binding Proteins / Q000652:urine*; D004715:Endometriosis / Q000175:diagnosis / Q000201:enzymology / Q000652:urine*; D005260:Female; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000652:urine*; D012372:ROC Curve; D025521:Tumor Suppressor Proteins / Q000652:urine*
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D003404:Creatinine; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase