title: Preparation of [(3) H]fluoroethyl tosylate and its use in the labelling of the dopamine transporter radioligand [(3) H]FE-PE2I.
abstract: [(3) H]Fluoroethyl tosylate, a novel alkylating tritium labelling agent, was synthesized from tritium gas with high specific activity and with 99% radiochemical purity. [(3) H]Fluoroethyl tosylate was applied in the tritium labelling of the dopamine transporter radioligand [(3) H]FE-PE2I.
authors.affiliation: University of Strathclyde, Department of Pure and Applied Chemistry, Glasgow, United Kingdom; University of Strathclyde, Pure and Applied Chemistry, 295 Cathedral Street, Glasgow, Scotland, G1 1XL, United Kingdom.
authors.forename: Alison R
authors.initials: AR
authors.lastname: Cochrane
authors.forename: William John
authors.initials: WJ
authors.lastname: Kerr
authors.forename: Johan
authors.initials: J
authors.lastname: Sandell
mesh_terms: D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000737:chemistry*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D007553:Isotope Labeling; D008024:Ligands; D009662:Nortropanes / Q000737:chemistry* / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: C543996:(E)-N-(3-iodoprop-2-enyl)-2beta-carbofluoroethoxy-3beta-(4'-methyl-phenyl) nortropane; C573194:4-methylbenzenesulfonic acid; D001557:Benzenesulfonates; D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D009662:Nortropanes; C000590219:fluoroethyl tosylate
keywords: PET radioligand; [3H]FE-PE21; [3H]fluoroethyl tosylate; dopamine transporter