title: Individuals with coronary artery disease at a young age and features of the metabolic syndrome have an increased prothrombotic potential.
abstract: The relation between coagulation and atherosclerosis has been extensively described, pointing towards a hypercoagulable state in patients with atherosclerosis, especially in young individuals. However, not all studies were conclusive. It is known that the metabolic syndrome (MetS), a risk factor for coronary artery disease (CAD), is related to a higher incidence of thrombo-embolic events. We hypothesised that individuals with CAD at a young age and MetS have an increased prothrombotic potential. It was the study objective to analyse the endogenous thrombin potential (ETP) and related thrombin generation parameters in patients with CAD before the age of 51 in men and 56 in women with and without MetS features and their healthy first-degree relatives. In this case-control study we included 118 CAD patients and 50 first-degree relatives (controls). Parameters of thrombin generation were obtained with calibrated automated thrombinography. An adjusted general linear model (GLM) showed a positive association between the peak thrombin levels and the presence of CAD at a young age. Based on the NCEP criteria we divided our patient group in CAD patients with and without MetS, and compared them to the controls without MetS. We showed that CAD patients with MetS have increased ETP levels, both in comparison with healthy first-degree relatives and with CAD patients without MetS. There were no differences in ETP between patients without MetS and healthy controls. In conclusion, this study shows that individuals with CAD at a young age and MetS features have an increased prothrombotic potential, compared to CAD patients without MetS.
authors.forename: M G M
authors.initials: MG
authors.lastname: Kok
authors.forename: J C M
authors.initials: JC
authors.lastname: Meijers
authors.affiliation: Dr. Sara-Joan Pinto-Sietsma, MD, PhD,, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Postbus 22660, Amsterdam 1100 DD, The Netherlands, E-mail: S.J.Pinto@amc.uva.nl.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Pinto-Sietsma
mesh_terms: D000328:Adult; D017668:Age of Onset; D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D011516:Prothrombin / Q000378:metabolism*; D012307:Risk Factors; D013917:Thrombin / Q000378:metabolism*; D019851:Thrombophilia / Q000453:epidemiology*
chemical_list: D011516:Prothrombin; D013917:Thrombin
keywords: Atherosclerosis; hypercoagulability; metabolic disorders; thrombin