title: Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: A prospective randomized clinical trial.
abstract: Some evidences have shown the role of antioxidant vitamins in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. We sought to determine the effect of oral vitamin C on the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
  
  
  
  One-hundred patients who underwent isolated CABG surgery were prospectively assigned into two groups: Group 1 - 50 patients received 2 g of oral vitamin C before and 500 mg twice daily lasting for 5 days after surgery; Group 2 - 50 patients as the control group did not receive any. All patients were continuously monitored after surgery in the intensive careunit (ICU), and then Holter monitoring was implemented for 72 h.
  
  
  
  The mean of patients' age was 61.31 ± 6.42 years. Postoperative AF occurred in 16 and 4 patients in control and treatment groups, respectively (32% vs. 8%, p = 0.003). The ICU stay was 1.79 ± 0.313 and 2.10 ± 0.61 days for vitamin C and control groups, respectively (p = 0.002). The hospital stay was significantly lower in vitamin C group compared with that of the control group (5.32 ± 0.59 vs. 5.74 ± 1.30 days, respectively, p = 0.041). Baseline erythrocyte sedimentation rate (OR 1.030, 95% CI 1.003-1.058, p = 0.030) and taking vitamin C (OR 8.068, 95% CI 1.783-36.517, p = 0.007) were the independent predictors of postoperative AF.
  
  
  
  Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Dehghani
authors.forename: Nader
authors.initials: N
authors.lastname: Majidi
authors.forename: Alireza
authors.initials: A
authors.lastname: Rahmani
authors.forename: Behnam
authors.initials: B
authors.lastname: Asgari
authors.affiliation: Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. yousefrezaei1986@gmail.com.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Rezaei
mesh_terms: D000284:Administration, Oral; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014815:Vitamins; D001205:Ascorbic Acid