title: Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report.
abstract: Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones were seen during the meals.
authors.affiliation: Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address:carsten.dirksen@hvh.regionh.dk.
authors.forename: Carsten
authors.initials: C
authors.lastname: Dirksen
authors.forename: Siv H
authors.initials: SH
authors.lastname: Jacobsen
authors.forename: Kirstine N
authors.initials: KN
authors.lastname: Bojsen-Møller
authors.forename: Nils B
authors.initials: NB
authors.lastname: Jørgensen
authors.forename: Lars S
authors.initials: LS
authors.lastname: Naver
authors.forename: Lisbeth E
authors.initials: LE
authors.lastname: Hvolris
authors.forename: Dorte
authors.initials: D
authors.lastname: Worm
authors.forename: Sten
authors.initials: S
authors.lastname: Madsbad
authors.forename: Jens J
authors.initials: JJ
authors.lastname: Holst
authors.forename: Dorte L
authors.initials: DL
authors.lastname: Hansen
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D050417:Insulin-Secreting Cells / Q000166:cytology*; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D012307:Risk Factors
chemical_list: D007328:Insulin