title: Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation.
abstract: Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core-shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively.
authors.affiliation: Departments of Chemistry and Chemical Engineering, Texas A&M University, P. O. Box 30012, College Station, Texas 77842, USA. wooley@chem.tamu.edu.
authors.forename: Sandani
authors.initials: S
authors.lastname: Samarajeewa
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Zentay
authors.forename: Nema D
authors.initials: ND
authors.lastname: Jhurry
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Kellie
authors.initials: K
authors.lastname: Seetho
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley
mesh_terms: D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism*; D055672:Static Electricity
chemical_list: D004798:Enzymes; D008823:Micelles; D011091:Polyesters; C033616:poly(lactide)