title: Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats.
abstract: Ethanol extract of Pleurotus eryngii (DC.) QUÉL has estrogen-like activities that protect against bone loss caused by estrogen deficiency. In the present study, we investigated the effect of P. eryngii on depression-like behavior and memory impairment in ovariectomized (OVX) rats. Immobility time during a forced swimming test was significantly longer for OVX rats than for sham-operated rats. The depression-like behavior in OVX rats was improved by long-term administration of the ethanol extract of P. eryngii (500 mg/kg body weight (b.w.)/d). Spatial memory impairment in OVX rats assessed by the Morris water maze test was also improved by P. eryngii extract without any effect on motility. These results suggested that P. eryngii extract has estrogen-like improvement activity against depression-like behavior and memory impairment in OVX rats. Additionally, increase in the amount of synaptosomal zinc after ovariectomy was inhibited by P. eryngii extract. Since zinc in synaptic vesicles is important for memory function and is linked to the pathophysiology of depression, normalization of zinc signaling would be involved in the beneficial effect of P. eryngii extract on neurological disorders after ovariectomy.
authors.affiliation: Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.
authors.forename: Akira
authors.initials: A
authors.lastname: Minami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsushita
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Horii
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ieno
authors.forename: Yukino
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Masakazu
authors.initials: M
authors.lastname: Saito
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakatsuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Kazuya I P J
authors.initials: KI
authors.lastname: Hidari
authors.forename: Vikineswary
authors.initials: V
authors.lastname: Sabaratnam
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000737:chemistry; D005260:Female; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000378:metabolism; D010052:Ovariectomy; D020076:Pleurotus; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D013574:Synaptosomes / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D001688:Biological Products; D004967:Estrogens; D012997:Solvents; D000431:Ethanol; D015032:Zinc