title: A case for neuroprotection in ophthalmology: developments in translational research.
abstract: Cellular aging occurs by the lifelong accumulation of oxidative damage leading to neuronal apoptosis, termed 'neurodegeneration', and the functional deficits of aging. Loss of visual function is one of the most important quality of life measures for older adults. We discuss recent clinical and laboratory advances in the neuroprotective treatment of the aging eye with particular emphasis on the three major ocular neurodegenerative conditions: glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR).
authors.affiliation: Department of Ophthalmology, University of Missouri, Kansas City School of Medicine, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Payne
authors.forename: Simon
authors.initials: S
authors.lastname: Kaja
authors.forename: Nelson R
authors.initials: NR
authors.lastname: Sabates
authors.forename: Peter
authors.initials: P
authors.lastname: Koulen
mesh_terms: D017209:Apoptosis; D035843:Biomedical Research / Q000639:trends*; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009885:Ophthalmology / Q000379:methods*; D011788:Quality of Life; D012164:Retinal Diseases / Q000473:pathology / Q000517:prevention & control*; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D018696:Neuroprotective Agents