title: Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.
abstract: The antiviral lectins griffithsin (GRFT), cyanovirin-N (CV-N), and scytovirin (SVN), which inhibit several enveloped viruses, including lentiviruses, were examined for their ability to inhibit entry mediated by Env proteins of delta- and gammaretroviruses. The glycoproteins from human T-cell leukemia virus type 1 (HTLV-1) were resistant to the antiviral effects of all three lectins. For gammaretroviruses, CV-N inhibited entry mediated by some but not all of the envelopes examined, whereas GRFT and SVN displayed only little or no effect.
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
authors.forename: Stig M R
authors.initials: SM
authors.lastname: Jensen
authors.forename: Francis W
authors.initials: FW
authors.lastname: Ruscetti
authors.forename: Alan
authors.initials: A
authors.lastname: Rein
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Bertolette
authors.forename: Carrie J
authors.initials: CJ
authors.lastname: Saucedo
authors.forename: Barry R
authors.initials: BR
authors.lastname: O'Keefe
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Jones
mesh_terms: D001426:Bacterial Proteins / Q000494:pharmacology*; D002352:Carrier Proteins / Q000494:pharmacology*; D017988:Gammaretrovirus / Q000187:drug effects / Q000502:physiology*; D006031:Glycosylation; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008565:Membrane Proteins; D037121:Plant Lectins / Q000494:pharmacology*; D014759:Viral Envelope Proteins / Q000378:metabolism*; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D037102:Lectins; D008565:Membrane Proteins; D037121:Plant Lectins; D014759:Viral Envelope Proteins; C474342:scytovirin protein, S varium; C107733:cyanovirin N; C499654:griffithsin protein, Griffithsia