title: Synergy of iron, high sensitivity C-reactive protein and ceruloplasmin with oxidative stress in non-diabetic normo-tensive South Indian obese men.
abstract: BACKGROUND
  Oxidative stress and inflammation are implicated in the pathogenesis of obesity and its related complications. Previous studies have suggested a potential link between obesity and altered iron metabolism. The present study was designed to evaluate iron, C-reactive protein, ceruloplasmin and oxidative stress and their association, if any, in non-diabetic normo-tensive South Indian obese men.
  
  
  METHODS
  30 obese men and 30 age-matched males with normal body weight were recruited in the study. Serum iron, copper, ceruloplasmin, high sensitivity C-reactive protein (hs-CRP), malondialdehyde, protein carbonyl, total oxidant status and total antioxidant status were estimated in all the subjects.
  
  
  RESULTS
  Serum iron, ceruloplasmin, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), protein carbonyl and total oxidant status were significantly increased and total antioxidant status was significantly reduced in obese men, compared to controls. Linear regression analysis shows highly significant positive association of iron with hs-CRP.
  
  
  CONCLUSIONS
  The data from the present study concludes that oxidative stress parameters, hs-CRP, iron and ceruloplasmin were significantly elevated in obese Indian men, suggesting they are more prone to develop cardiovascular disease, than age-matched men with normal body weight.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India. Electronic address: linkmedha@gmail.com.
authors.forename: Medha
authors.initials: M
authors.lastname: Rajappa
authors.forename: Ravichandra
authors.initials: R
authors.lastname: Tagirasa
authors.forename: Hanumanthappa
authors.initials: H
authors.lastname: Nandeesha
authors.forename: Abdoul
authors.initials: A
authors.lastname: Hamide
authors.forename: Indhumathi
authors.initials: I
authors.lastname: Sundar
authors.forename: Palghat Hariharan
authors.initials: PH
authors.lastname: Ananthanarayanan
authors.forename: A
authors.initials: A
authors.lastname: Vengattaraman
authors.forename: Durgadevi
authors.initials: D
authors.lastname: Thiyagarajan
authors.forename: K T
authors.initials: KT
authors.lastname: Harichandrakumar
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control; D002570:Ceruloplasmin / Q000378:metabolism*; D006801:Humans; D007194:India / Q000453:epidemiology; D007249:Inflammation / Q000097:blood*; D007501:Iron / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D054526:Men's Health; D009765:Obesity / Q000097:blood* / Q000150:complications; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D002097:C-Reactive Protein; D007501:Iron; D002570:Ceruloplasmin
keywords: C-reactive protein; Ceruloplasmin; Iron; Obesity; Oxidative stress