title: [Relationship between serum β2-microglobulin and lower extremity atherosclerotic occlusive disease].
abstract: OBJECTIVE
  To explore the relationship between fasting serum level of β2-microglobulin (β2-M) and the development of lower extremity atherosclerotic occlusive disease (LEAOD).
  
  
  METHODS
  A total of 59 LEAOD patients at our hospital from March 2011 to August 2012 were recruited into the LEAOD group while another 32 non-LEAOD patients into the control group. Their clinical profiles and the parameters of ankle brachial index (ABI),β2-M and high-sensitivity C-reactive protein (hsCRP) were recorded and analyzed.
  
  
  RESULTS
  The patients had higher serum levels of β2-M (5.3 ± 3.2 vs 2.6 ± 1.3) and hsCRP (15.1 ± 14.8 vs 8.0 ± 6.7) according to the severity in the LEAOD group than those in the control group (P < 0.05).β2-M was correlated with smoking (β 1.248, odds ratio[OR] 0.020, 95% confidence interval [CI] 1.221-9.942), diabetes (β 1.524,OR 4.591, 95%CI 1.493-14.118) and ABI (β-4.091,OR 0.017, 95%CI 0.002-0.136) . The receiver operating characteristic (ROC) curve showed that β2-M level had some value of predicting the occurrence of LEAOD (ROCAUC 0.821, 95%CI 0.731-0.912, P < 0.01).
  
  
  CONCLUSIONS
  Serum level of β2-M may play a role in pathologic process of LEAOD. And further studies are needed to validate its value as a biomarker for LEAOD.
authors.affiliation: Department of Vascular Surgery,General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Hai-yong
authors.initials: HY
authors.lastname: Liu
authors.forename: Xue-min
authors.initials: XM
authors.lastname: Zhang
authors.forename: Chun-fang
authors.initials: CF
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Sen-hao
authors.initials: SH
authors.lastname: Jia
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001161:Arteriosclerosis / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin; D002097:C-Reactive Protein