title: Safety and effectiveness of the Genous endothelial progenitor cell-capture stent: follow-up to 5 years.
abstract: OBJECTIVE
  To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population.
  
  
  METHODS
  All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR).
  
  
  RESULTS
  Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR.
  
  
  CONCLUSIONS
  This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population.
authors.affiliation: Cardiology Department, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisbon, Portugal. tiagopsilva@sapo.pt.
authors.forename: Tiago
authors.initials: T
authors.lastname: Pereira-da-Silva
authors.forename: Luís
authors.initials: L
authors.lastname: Bernardes
authors.forename: Duarte
authors.initials: D
authors.lastname: Cacela
authors.forename: António
authors.initials: A
authors.lastname: Fiarresga
authors.forename: Lídia
authors.initials: L
authors.lastname: Sousa
authors.forename: Lino
authors.initials: L
authors.lastname: Patrício
authors.forename: Rui Cruz
authors.initials: RC
authors.lastname: Ferreira
mesh_terms: D054058:Acute Coronary Syndrome / Q000473:pathology / Q000628:therapy*; D000368:Aged; D023903:Coronary Restenosis / Q000453:epidemiology; D003328:Coronary Thrombosis / Q000453:epidemiology; D066026:Endothelial Progenitor Cells / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation* / Q000379:methods*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome