title: Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury.
abstract: Myocardial ischemia-reperfusion (MIR) injury is a major contributor to the morbidity and mortality associated with coronary artery disease, which accounts for approximately 450,000 deaths a year in the United States alone. Chinese herbal medicine, especially combined herbal formulations, has been widely used in traditional Chinese medicine for the treatment of myocardial infarction for hundreds of years. While the efficacy of Chinese herbal medicine is well documented, the underlying molecular mechanisms remain elusive. In this review, we highlight recent studies which are focused on elucidating the cellular and molecular mechanisms using extracted compounds, single herbs, or herbal formulations in experimental settings. These studies represent recent efforts to bridge the gap between the enigma of ancient Chinese herbal medicine and the concepts of modern cell and molecular biology in the treatment of myocardial infarction.
authors.affiliation: Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA ; The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Janicki
authors.forename: Daping
authors.initials: D
authors.lastname: Fan