title: Huai Qi Huang ameliorates proteinuria and hematuria in mild IgA nephropathy patients: a prospective randomized controlled study.
abstract: OBJECTIVE
  Huai Qi Huang (HQH) is a compound Chinese herbal medicine that contains Trametes robiniophila murr, wolfberry fruit, and Polygonatum. In the present study, we investigated the effects of HQH on patients with mild immunoglobulin A nephropathy (IgAN) through a prospective randomized controlled study.
  
  
  METHODS
  Forty-five adults diagnosed with IgAN according to renal pathology, who had hematuria or/and proteinuria (≤ 2 g/day), were randomly assigned to receive HQH or no treatment for 12 weeks. Twenty-four hour urinary protein excretion and hematuria were measured at Weeks 0, 4, 8, and 12. The rate of complete remission of proteinuria and hematuria was evaluated. Any adverse events induced by HQH were also observed during the treatment period.
  
  
  RESULTS
  Twenty-four hour urinary protein excretion was significantly reduced by HQH treatment compared with that in the control group at Weeks 8 and 12. A much higher rate of complete remission of proteinuria was observed in the HQH group than in control group at Week 12. HQH administration also obviously reduced the extent of hematuria compared with that in the control group at Week 12. HQH treatment dramatically increased the rate of complete remission of hematuria compared with that in control group at Weeks 8 and 12. No obvious adverse events caused by HQH were observed.
  
  
  CONCLUSIONS
  HQH could be a new conservative therapy for IgAN patients who cannot tolerate steroids and immunosuppressive agents. The relapse rate after discontinuing treatment still needs further investigation.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Lei-Ting
authors.initials: LT
authors.lastname: Li
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Shi
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Shi-Yao
authors.initials: SY
authors.lastname: Wei
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Nephrology, Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China. Electronic address: icecreamlee@hotmail.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000188:drug therapy*; D006417:Hematuria / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D032305:Lycium; D008297:Male; D008517:Phytotherapy; D031384:Polygonatum; D011446:Prospective Studies; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D055454:Trametes; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; C000593291:huai qi huang
keywords: Huai Qi Huang granule; hematuria; immunoglobulin A nephropathy; proteinuria