title: Lack of association of three common polymorphisms in toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with cancer risk: a meta-analysis.
abstract: BACKGROUND
  Single nucleotide polymorphisms (SNPs) occurring in Toll-like receptors (TLRs) may contribute to cancer risk. Many polymorphisms of TLR2 have been studied for associations, but the findings are conflicting.
  
  
  RESULTS
  We performed a meta-analysis of 14 studies to confirm the association between TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of associations. There was no significant association between TLR2+597T>C and cancer risk in the codominant models (CC vs. TT: OR = 1.01, 95%CI = 0.86-1.17, Pheterogeneity = 0.148; CT vs. TT: OR = 0.92, 95%CI = 0.69-1.23, Pheterogeneity < 0.001), the recessive model (CC vs. CT+TT: OR = 0.86, 95%CI = 0.67-1.10, Pheterogeneity = 0.007) , the dominant model (CC+CT vs. TT: OR = 0.93, 95%CI = 0.76-1.15, Pheterogeneity = 0.001) and the allele model (C vs. T: OR = 0.93, 95%CI = 0.81-1.08, Pheterogeneity = 0.019). Similarly, no significant associations between TLR2+1350C>T, Arg753Gln polymorphisms and cancer risk were found. However, in the sub-group analysis of ethnicities, the trend of pooled ORs in Asians was opposite to Caucasians.
  
  
  CONCLUSIONS
  The present meta-analysis suggests that TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms are not associated with cancer risk.
authors.affiliation: The First Clinical College of Nanjing Medical University, Nanjing, China E-mail : xulin83cn@gmail.com, ctzs123@sina.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Wang
authors.forename: Man-Tang
authors.initials: MT
authors.lastname: Qiu
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Hu
authors.forename: Rong
authors.initials: R
authors.lastname: Yin
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D051193:Toll-Like Receptors / Q000235:genetics*
chemical_list: D051193:Toll-Like Receptors