title: Chiral amide directed assembly of a diastereo- and enantiopure supramolecular host and its application to enantioselective catalysis of neutral substrates.
abstract: The synthesis of a novel supramolecular tetrahedral assembly of K12Ga4L6 stoichiometry is reported. The newly designed chiral ligand exhibits high diastereoselective control during cluster formation, leading exclusively to a single diastereomer of the desired host. This new assembly also exhibits high stability toward oxidation or a low pH environment and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates.
authors.affiliation: Chemical Sciences Division, Lawrence Berkeley National Laboratory, and Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhao
authors.forename: Qing-Fu
authors.initials: QF
authors.lastname: Sun
authors.forename: William M
authors.initials: WM
authors.lastname: Hart-Cooper
authors.forename: Antonio G
authors.initials: AG
authors.lastname: DiPasquale
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
authors.forename: Robert G
authors.initials: RG
authors.lastname: Bergman
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Raymond
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000577:Amides