title: Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.
abstract: Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein-protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient's risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions.
authors.affiliation: Department of Cell Biology, Emory University School of Medicine, Center for Social Translational Neuroscience, Emory University, Atlanta, GA, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Mullin
authors.forename: A
authors.initials: A
authors.lastname: Gokhale
authors.forename: A
authors.initials: A
authors.lastname: Moreno-De-Luca
authors.forename: S
authors.initials: S
authors.lastname: Sanyal
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
authors.forename: V
authors.initials: V
authors.lastname: Faundez
mesh_terms: D002659:Child Development Disorders, Pervasive / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D002658:Developmental Disabilities / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D016678:Genome / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability; D020543:Proteome / Q000378:metabolism*; D012559:Schizophrenia / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D020543:Proteome