title: Combined long-acting bronchodilator single therapy for COPD.
abstract: BACKGROUND
  In COPD, the long-acting bronchodilators are not always able to provide an appropriate bronchodilator effect in terms of amplitude and duration and this can result in increased severity of respiratory symptoms and in worsening of health status. Combined long-acting bronchodilators can address this limitation.
  
  
  METHODS
  Analysis of a recent study evaluating the efficacy and safety of 26 weeks of therapy with glycopyrronium+indacaterol single inhaler (QVA149) versus each component, versus tiotropium and versus placebo.
  
  
  CONCLUSIONS
  Such a combination can provide a superior and sustained bronchodilator effect and can minimize the respiratory symptoms resulting from a suboptimally inhibited bronchoconstriction.
authors.affiliation: University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Faculty of Medicine-Pulmonary Disease , 6 B.P. Hasdeu Street, Cluj-Napoca, 400371 , Romania.
authors.forename: Ruxandra Mioara
authors.initials: RM
authors.lastname: Râjnoveanu
authors.forename: Sabina
authors.initials: S
authors.lastname: Antoniu
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Ulmeanu
mesh_terms: D001993:Bronchodilator Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005541:Forced Expiratory Volume; D006024:Glycopyrrolate / Q000008:administration & dosage*; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D008297:Male; D009330:Nebulizers and Vaporizers; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D015363:Quinolones / Q000008:administration & dosage*
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D007189:Indans; D015363:Quinolones; C510790:indacaterol; D006024:Glycopyrrolate