title: Ocular drug delivery for glaucoma management.
abstract: Current glaucoma management modalities are hindered by low patient compliance and adherence. This can be due to highly complex treatment strategies or poor patient understanding. Treatments focus on the management or reduction of intraocular pressure. This is most commonly done through the use of daily topical eye drops. Unfortunately, despite effective therapies, glaucoma continues to progress, possibly due to patients not adhering to their treatments. In order to mitigate these patient compliance issues, many sustained release treatments are being researched and are entering the clinic. Conjunctival, subconjunctival, and intravitreal inserts, punctal plugs, and drug depots are currently in clinical development. Each delivery system has hurdles, yet shows promise and could potentially mitigate the current problems associated with poor patient compliance.
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. barbara.wirostko@gmail.com.
authors.forename: Nathan
authors.initials: N
authors.lastname: Gooch
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Molokhia
authors.forename: Russell
authors.initials: R
authors.lastname: Condie
authors.forename: Randon Michael
authors.initials: RM
authors.lastname: Burr
authors.forename: Bonnie
authors.initials: B
authors.lastname: Archer
authors.forename: Balamurali K
authors.initials: BK
authors.lastname: Ambati
authors.forename: Barbara
authors.initials: B
authors.lastname: Wirostko