title: Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit.
abstract: Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gram-negative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 μg/ml against P. vulgaris, 25 μg/ml against K. pneumoniae (ESBL-3971), 8 μg/ml against M. tuberculosis (H(37)Rv) and 8 μg/ml against M. tuberculosis (Rif(R)). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.
authors.affiliation: Division of Microbiology, Entomology Research Institute, Loyola College, Chennai, 600 034 India.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Balachandran
authors.forename: Veeramuthu
authors.initials: V
authors.lastname: Duraipandiyan
authors.forename: Naif Abdullah
authors.initials: NA
authors.lastname: Al-Dhabi
authors.forename: K
authors.initials: K
authors.lastname: Balakrishna
authors.forename: Nitin Pal
authors.initials: NP
authors.lastname: Kalia
authors.forename: Vikrant Singh
authors.initials: VS
authors.lastname: Rajput
authors.forename: Inshad Ali
authors.initials: IA
authors.lastname: Khan
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
keywords: Antimicrobial; Antimycobacterial; Methyl caffeate; Solanum torvum