title: Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess.
abstract: A 73-year-old Japanese man developed chronic intractable itching due to prurigo nodularis. High-dose glucocorticoid ointment failed, and the treatment resulted in poor glycemic control. Repeated scratching caused hematogenous bacterial dissemination via cutaneous injuries, resulting in the formation of iliopsoas and spinal epidural abscesses that required long-term antibiotic treatment. Pregabalin was administered to treat the pruritus, and a considerable improvement was observed. A reduction in the dose and intensity of the topical corticosteroids improved the patient's glycemic control, resulting in the complete resolution of the abscesses. Pregabalin significantly improved the patient's pruritus and decreased the risk of infection.
authors.affiliation: Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Japan.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Imai
authors.forename: Miyako
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tsujimoto
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Yamamoto-Honda
authors.forename: Noriko
authors.initials: N
authors.lastname: Ihana
authors.forename: Kanako
authors.initials: K
authors.lastname: Ono
authors.forename: Remi
authors.initials: R
authors.lastname: Hachiya
authors.forename: Kaori
authors.initials: K
authors.lastname: Inoue
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Goto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajio
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000982:Antipruritics / Q000008:administration & dosage; D048909:Diabetes Complications / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000069583:Pregabalin; D011536:Prurigo / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D016659:Psoas Abscess / Q000150:complications* / Q000175:diagnosis; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000305:Adrenal Cortex Hormones; D000982:Antipruritics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid