title: Alum catalyzed simple, efficient, and green synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media.
abstract: Alum (KAl(SO4)2 · 12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6), and thiosemicarbazide (4) at 80 °C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR, (13)C NMR, and (1)HNMR spectroscopy.
authors.affiliation: Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, India.
authors.forename: Harshita
authors.initials: H
authors.lastname: Sachdeva
authors.forename: Diksha
authors.initials: D
authors.lastname: Dwivedi
authors.forename: Rekha
authors.initials: R
authors.lastname: Saroj
mesh_terms: D000534:Alum Compounds / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D055772:Green Chemistry Technology / Q000379:methods*; D011422:Propionates / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis; D012663:Semicarbazides / Q000138:chemical synthesis
chemical_list: D000534:Alum Compounds; D000596:Amino Acids; D011422:Propionates; D011725:Pyridines; D012663:Semicarbazides; C010835:3-acetylpyridine; C005151:thiosemicarbazide