title: N-Difluoromethylation of imidazoles and benzimidazoles using the Ruppert-Prakash reagent under neutral conditions.
abstract: Direct N-difluoromethylation of imidazoles and benzimidazoles has been achieved using TMS-CF3 (the Ruppert-Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good-to-excellent yields. Inexpensive, commercially available starting materials, neutral conditions, and shorter reaction times are advantages of this methodology. Reactions are accessible through conventional as well as microwave irradiation conditions.
authors.affiliation: Donald P. and Katherine B. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California , Los Angeles, California 90089-1661, United States.
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
authors.forename: Sankarganesh
authors.initials: S
authors.lastname: Krishnamoorthy
authors.forename: Somesh K
authors.initials: SK
authors.lastname: Ganesh
authors.forename: Aditya
authors.initials: A
authors.lastname: Kulkarni
authors.forename: Ralf
authors.initials: R
authors.lastname: Haiges
authors.forename: George A
authors.initials: GA
authors.lastname: Olah