title: Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate.
abstract: Automated synthetic procedures of [(18)F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-commercial synthesis module have been developed. The syntheses included azeotropic drying of the [(18)F]fluoride, nucleophilic (18)F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [(18)F]fluoro-[di-deutero]methyl tosylate (d2-[(18)F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated (18)F-fluoromethylated imaging probes in the future.
authors.affiliation: Institute of Nuclear Chemistry, Johannes Gutenberg-University, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Beyerlein
authors.forename: Markus
authors.initials: M
authors.lastname: Piel
authors.forename: Sabine
authors.initials: S
authors.lastname: Höhnemann
authors.forename: Frank
authors.initials: F
authors.lastname: Rösch
mesh_terms: D057205:Automation, Laboratory; D001557:Benzenesulfonates / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003903:Deuterium / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods
chemical_list: D001557:Benzenesulfonates; D005462:Fluorine Radioisotopes; C506825:methyl tosylate; D003903:Deuterium
keywords: 18F-fluoromethylation; PET; [18F]fluorine; [18F]fluoromethyl tosylate; automated synthesis