title: Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects.
abstract: Hoodia gordonii, a popular appetite suppressant, is widely used as an ingredient in many food supplements despite the fact that supporting scientific evidence is scarce. Recently alarming side effects of H. gordonii products (increased blood pressure and elevated pulse rate) have been reported. The aim of our study was to elucidate the underlying mechanism of these symptoms. A H. gordonii-containing product was tested for sympathomimetic activity. Isolated organ experiments on rat uterine rings revealed smooth muscle relaxant effect with a substantial component mediated through β -adrenergic receptors. Chromatographic comparison of the analyzed product and authentic plant material confirmed that the herbal product contained Hoodia spp. extract, and its cardiovascular effects may be linked to the compounds of the plant.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged 6720, Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Roza
authors.forename: Norbert
authors.initials: N
authors.lastname: Lovász
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
authors.forename: Dezső
authors.initials: D
authors.lastname: Csupor
mesh_terms: D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002319:Cardiovascular System / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D005260:Female; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D009119:Muscle Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013566:Sympathomimetics / Q000009:adverse effects*; D014599:Uterus / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D013566:Sympathomimetics