title: Antithrombogenic activity of antioxidant compounds.
abstract: Antithrombotic activities of enoxifol, a new antioxidant with antiaggregant activity demonstrated in vitro and in vivo, and antioxidant mexidol were compared on the rat model of arterial thrombosis induced by application of 50% ferric chloride. Acetylsalicylic acid (antiaggregant) served as the reference drug. All drugs exhibited dose-dependent antithrombotic activity. Enoxifol was more effective than mexidol, both drugs being more active than the reference drug (acetylsalicylic acid). Taking into account the pathogenesis of the thrombosis in this experimental model, we can hypothesize that the pronounced antithrombotic effect of enoxifol was due to its antiaggregant and antioxidant activities.
authors.affiliation: Department of Pharmacology, Volgograd State Medical University; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia. aspasov@mail.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheryavenko
authors.forename: V A
authors.initials: VA
authors.lastname: Kosolapov
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D002341:Carotid Artery Thrombosis / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
chemical_list: D000925:Anticoagulants; D000975:Antioxidants; D001562:Benzimidazoles; D010847:Picolines; C000589732:enoxifol; C070020:emoxypine succinate; D001241:Aspirin