title: Cytochrome p450 part 2: what nurses need to know about the cytochrome p450 family systems.
abstract: To provide the best patient care related to medication administration and prescription, an understanding of the specific enzymes is essential. Enzymes affect the metabolizing of most medications that nurses administer and that nurse practitioners and physicians prescribe on a regular basis. More specifically, the most important p450 enzymes in drug metabolism are cytochrome p450 (CYP) 1A2, the CYP2C family, CYP2D6, and CYP3A4. In addition, the enzymes are instrumental in the body's reaction to environmental factors, some of which are carcinogens.
authors.affiliation: Vanderbilt University Medical Center, School of Nursing, 461 21st Avenue South, Nashville, TN 37205, USA. Electronic address: steve.krau@vanderbillt.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Krau
mesh_terms: D002983:Clinical Competence; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D024802:Nurse's Role; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D057184:Practice Patterns, Nurses' / Q000458:organization & administration*; D057285:Precision Medicine / Q000451:nursing*
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6
keywords: CYP1; CYP2; Cytochrome p450; Drug metabolism; Enzyme families; Pharmacogenomics; Pharmacokinetics