title: Fluticasone nasal spray as an adjunct to Amoxicillin for acute sinusitis in children: a randomized controlled trial.
abstract: BACKGROUND
  Approximately 0.5-2% of upper respiratory tract infections in adults and 6-13% of viral upper respiratory tract infections in children are complicated by acute sinusitis. This study was aimed to evaluate the coadministration effect of fluticasone nasal spray (FNS) with amoxicillin for AS in children.
  
  
  METHODS
  One hundred children 2 to 14 years of age with acute sinusitis referred to Shahid Mohammadi Pediatric Hospital in Bandar Abbas were randomly allocated into two equal intervention and control groups to receive amoxicillin with fluticasone nasal spray one puff twice daily for 14 days and amoxicillin 80 to 100 mg/kg/ day for 14 days respectively.
  
  
  RESULTS
  Twenty one (42%) of children in intervention group were cured completely and 2 (4%) children in control group had complete recovery (p < 0.001). Symptom severity score was 22.98 ± 2.95 before treatment that reduced to 13.26 ± 3.20 after treatment (p < 0.001).
  
  
  CONCLUSIONS
  Use of fluticasone can reduce the severity of symptoms of sinusitis in children.
authors.affiliation: Department of Pediatrics, Department of ENT, Hormozgan University of Medical Sciences, Bandarabas, Iran. drmsrezaii@yahoo.com.
authors.forename: M B
authors.initials: MB
authors.lastname: Rahmati
authors.forename: S
authors.initials: S
authors.lastname: Mohebi
authors.forename: S
authors.initials: S
authors.lastname: Shahmohammadi
authors.forename: M S
authors.initials: MS
authors.lastname: Rezai
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage*; D000730:Androstadienes / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D000730:Androstadienes; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000658:Amoxicillin; D000068298:Fluticasone