title: Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice.
abstract: To investigate the pharmacological effects of Danggui Buxue Tang (DBT) on immune-mediated aplasia anemia mice. The model of immune-mediated aplasia anemia mice was induced by means of (60)Co γ-ray irradiation and mixed cells of thymus and lymphnode of DBA/2 mice infusion through tail vein, the parameters tested indices were as following: blood picture, bone marrow nucleated cell count (BMNC), murine colony-forming unit-megakaryocytes (CFU-GM) of bone marrow cells, murine colony-forming unit-erthroid (CFU-E) and burst forming unit-erythroid (BFU-E). The results showed that DBT could not only withstand significantly decreation of blood cells by immune-mediated, but also stimulate on the growth of bone marrow colony cell and increase the weight of hemopoietic progenitor of bone marrow. Therefore, DBT had an obvious treat effect on immune-mediated aplasia anemia models mice.
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, PR China; College of Life Sciences, Chongqing Normal University, Chongqing 401331, PR China. Electronic address: dushouying@263.net.
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.affiliation: Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China.
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Huang
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Shou-Ying
authors.initials: SY
authors.lastname: Du
authors.affiliation: College of Resources and Environment, Southwest University, Chongqing 400716, PR China.
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: Yang
authors.affiliation: Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China.
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Liu
authors.affiliation: Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China.
authors.lastname: Xian-QinLuo
authors.affiliation: Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Xu
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D011897:Random Allocation
chemical_list: D004365:Drugs, Chinese Herbal; C477279:danggui buxue decoction
keywords: Aplastic anemia mice; Bone marrow colony cell; Danggui Buxue Tang; Immune-mediated; TCM Formula