title: Effect of platelet-rich plasma on bone regeneration after removal of cysts and benign tumours of the jaws.
abstract: BACKGROUND
  Platelets are involved in regeneration at sites of pathology, apart from their role in clotting. A preparation composed mainly of platelets (platelet-rich plasma gel) applied to sites of bony pathology, after surgical treatment of lesions, may hasten bone regeneration.
  
  
  METHODS
  An autologous platelet-rich plasma (PRP) gel was prepared using a standardized technique, without using thrombin clot accelerator, and applied to surgical site in six patients of study group. Five patients were enrolled as controls, in whom PRP gel was not used. The differences in the occurrence of radiographic changes between the study and control group at 6, 12, 18 and 24 weeks after surgery were analysed with chi-square test. Intragroup radiographic changes, i.e. within the study and control groups occurring over the 24 weeks of follow-up, were analysed with Friedman test.
  
  
  RESULTS
  A trend towards more rapid healing was observed in the study group at 6, 12, 18 and 24 weeks. However, these differences between the study and control group were not statistically significant. Both the study and control group demonstrated significant healing changes over the 24 weeks of follow-up.
  
  
  CONCLUSIONS
  It is possible to prepare platelet-rich plasma gel without using thrombin clot accelerator. PRP, as prepared and applied to surgical sites in this study, was not observed to significantly enhance bone regeneration. All surgical sites, both in the PRP and control group, showed significant healing changes over 6 months.
authors.affiliation: Manipal College of Dental Sciences, Manipal University Mangalore, Mangalore, Karnataka, India, arvind_dent@yahoo.co.in.
authors.forename: Arvind
authors.initials: A
authors.lastname: Ramanathan
authors.forename: K M
authors.initials: KM
authors.lastname: Cariappa
mesh_terms: D001804:Blood Transfusion, Autologous / Q000379:methods; D001861:Bone Regeneration / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D007570:Jaw Cysts / Q000000981:diagnostic imaging / Q000601:surgery*; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011859:Radiography; D014945:Wound Healing / Q000502:physiology