title: Modeling chronic hepatitis B or C virus infection during antiviral therapy using an analogy to enzyme kinetics: long-term viral dynamics without rebound and oscillation.
abstract: The basic model for chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection during therapy enables us to analyze short-term viral kinetics. However, the model is not useful for analyzing long-term viral kinetics. Here, I suggest a new model that was obtained by introducing Michaelis-Menten kinetics into the basic model. The new model can exhibit long-term viral kinetics without rebound and oscillation, unlike the basic model. The value of the parameter K in the new model is analogous to the Michaelis constant Km and is predicted to be approximately less than 10(10)/ml.
authors.affiliation: Sapporo Ryokuai Hospital, 1-1, Kitano, Kiyota-Ku, Sapporo, Hokkaido, 004-0861, Japan. Electronic address: takayanagi@ryokuai.com.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Takayanagi
mesh_terms: D016174:Hepacivirus / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000378:metabolism / Q000628:therapy; D019698:Hepatitis C, Chronic / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007700:Kinetics; D008954:Models, Biological
keywords: Chronic viral hepatitis; Hepatitis B virus (HBV); Hepatitis C virus (HCV); Mathematical model; Michaelis–Menten; Rapid equilibrium; Viral kinetics