title: Association of RAGE gene polymorphisms with sporadic Parkinson's disease in Chinese Han population.
abstract: Previous studies have corroborated receptor for advanced glycation end-products (RAGE) ablation had a protective effect on nigral dopaminergic neurons in the MPTP model of Parkinson's disease (PD). Genetic variation of RAGE gene may be associated with the development of onset of sporadic PD. The present study aimed to explore the possible association of RAGE gene polymorphisms namely -374T/A,-429T/C, and G82S with PD. A total of 285 PD patients and 285 healthy-matched individuals in Chinese Han population were enrolled. Genotype analyses were performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Only the -429T/C polymorphism denoted a significant difference between PD patients and controls (P=0.015) of the three examined single nucleotide polymorphisms (SNPs). Our data also revealed that -429C allele carriers seem to have a decreased risk of PD (OR=0.617, P=0.007). Moreover, there were significant differences in genotype distribution in female PD group and its healthy-matched control subgroup (P=0.014), as well as between late-onset PD (LOPD) and the controls subgroup (P=0.016). However, for -374T/A and 82GS polymorphisms, there was no significant difference in the genotype and allele frequencies between PD patients and the controls, as well as gender- and age-related differences. Our present findings indicate that the RAGE -429T/C polymorphism may be associated with the susceptibility of PD and the CC genotype of -429T/C may be a protective factor for PD in Chinese Han population.
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Jijun
authors.initials: J
authors.lastname: Teng
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Neurology, Beijing Xuanwu Hospital, Chinese Human Genetic Center, Beijing, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. Electronic address: xieanmu@163.com.
authors.forename: Anmu
authors.initials: A
authors.lastname: Xie
mesh_terms: D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*
chemical_list: D000067759:Receptor for Advanced Glycation End Products
keywords: Parkinson's disease (PD); RAGE gene; Single nucleotide polymorphisms (SNPs).