title: Alloreactive T cells and 'the persistence of memory'.
abstract: Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on the presence or absence of donor-reactive effector memory T cells could influence clinical outcomes, but independent of such therapy, when 'the persistence of memory' prevails, allograft injury may occur.
authors.affiliation: Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Emilio D
authors.initials: ED
authors.lastname: Poggio
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Augustine
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007156:Immunologic Memory / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D007519:Isoantigens