title: Early treatment of Kallmann syndrome may prevent eunuchoid appearance and behavior.
abstract: Kallmann syndrome (KS) is a genetic disorder which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia due to olfactory bulb aplasia. KS treatment usually begins just before puberty, but brain sexual maturation occurs long before puberty normally at perinatal age. As brain cells implicated in the development of the olfactory and reproductive system have a rostral and a caudal origin, and the rostral origin is affected by aplasia in KS and the caudal origin does not seem to be affected, the early treatment of KS, as proposed in this paper, is to attain brain sexual maturation at the most appropriate age possible to prevent the eunuchoid behavior and appearance observed in KS.
authors.affiliation: Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain; Instituto dey Ciencias de Puerto del Rosario, Puerto del Rosario, Fuerteventura, Islas Canarias, Spain. Electronic address: acastaneyra@gmail.es.
authors.forename: Agustín
authors.initials: A
authors.lastname: Castañeyra-Perdomo
authors.affiliation: Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain; Departamento de Farmacologiıa, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain.
authors.forename: Leandro
authors.initials: L
authors.lastname: Castañeyra-Ruiz
authors.affiliation: Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: González-Marrero
authors.affiliation: Instituto dey Ciencias de Puerto del Rosario, Puerto del Rosario, Fuerteventura, Islas Canarias, Spain.
authors.forename: Agustin
authors.initials: A
authors.lastname: Castañeyra-Ruiz
authors.affiliation: Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Gonzalez-Toledo
authors.affiliation: Instituto dey Ciencias de Puerto del Rosario, Puerto del Rosario, Fuerteventura, Islas Canarias, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Castañeyra-Ruiz
authors.affiliation: Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain; Instituto dey Ciencias de Puerto del Rosario, Puerto del Rosario, Fuerteventura, Islas Canarias, Spain.
authors.forename: Emilia M
authors.initials: EM
authors.lastname: Carmona-Calero
mesh_terms: D000367:Age Factors; D001526:Behavioral Symptoms / Q000517:prevention & control*; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology; D006801:Humans; D017436:Kallmann Syndrome / Q000188:drug therapy* / Q000473:pathology*; D008954:Models, Biological; D012741:Sexual Maturation / Q000502:physiology*