title: EGF receptor trafficking: consequences for signaling and cancer.
abstract: The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of that traffic in signal transduction. Although such studies have largely focused on mitogenic signaling and dysregulated traffic in tumorigenesis, there is growing interest in the potential role of EGFR traffic in cell survival and the consequent response to cancer therapy. Here we review recent advances in our understanding of molecular mechanisms regulating ligand-stimulated EGFR activation, internalization, and post-endocytic sorting. The role of EGFR overexpression/mutation and new modulators of EGFR traffic in cancer and the response to cancer therapeutics are also discussed. Finally, we speculate on the relationship between EGFR traffic and cell survival.
authors.affiliation: University College London (UCL) Institute of Ophthalmology, London, UK.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Tomas
authors.affiliation: University College London (UCL) Institute of Ophthalmology, London, UK.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Futter
authors.affiliation: University College London (UCL) Institute of Ophthalmology, London, UK. Electronic address: e.eden@ucl.ac.uk.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Eden
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004705:Endocytosis; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D051380:GRB2 Adaptor Protein / Q000378:metabolism; D006801:Humans; D057146:Multivesicular Bodies / Q000378:metabolism; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D021381:Protein Transport; D059748:Proteolysis; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D000970:Antineoplastic Agents; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; D066246:ErbB Receptors
keywords: antineoplastic therapy; endocytosis; epidermal growth factor receptor (EGFR); oncogenes; trafficking; ubiquitination