title: Adolescents and alcohol: acute sensitivities, enhanced intake, and later consequences.
abstract: Adolescence is an evolutionarily conserved developmental period characterized by notable maturational changes in the brain along with various age-related behavioral characteristics, including the propensity to initiate alcohol and other drug use and consume more alcohol per occasion than adults. After a brief review of adolescent neurobehavioral function from an evolutionary perspective, the paper will turn to assessment of adolescent alcohol sensitivity and consequences, with a focus on work from our laboratory. After summarizing evidence showing that adolescents differ considerably from adults in their sensitivity to various effects of alcohol, potential contributors to these age-typical sensitivities will be discussed, and the degree to which these findings are generalizable to other drugs and to human adolescents will be considered. Recent studies are then reviewed to illustrate that repeated alcohol exposure during adolescence induces behavioral, cognitive, and neural alterations that are highly specific, replicable, persistent and dependent on the timing of the exposure. Research in this area is in its early stages, however, and more work will be necessary to characterize the extent of these neurobehavioral alterations and further determine the degree to which observed effects are specific to alcohol exposure during adolescence.
authors.affiliation: Department of Psychology, Developmental Exposure Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY 13902-6000, United States. Electronic address: Lspear@binghamton.edu.
authors.forename: Linda Patia
authors.initials: LP
authors.lastname: Spear
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000187:drug effects*; D000428:Alcohol Drinking / Q000503:physiopathology*; D001526:Behavioral Symptoms / Q000139:chemically induced*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008137:Longitudinal Studies
chemical_list: D000431:Ethanol
keywords: Adolescent; Alcohol; Fear conditioning; Incentive salience; Rodent model; Social anxiety