title: Unexpected conversion from hypothyroidism to an euthyroid state due to Graves' disease in a patient with an ectopic thyroid.
abstract: A 15-year-old woman was diagnosed with hypothyroidism and unilateral ectopic thyroid. Levothyroxine treatment was introduced; however, the patient was non-compliant and took the medication irregularly. When she presented to an endocrinologist at the age of 30, she had not been using levothyroxine for at least 6 months. Surprisingly, she was clinically and biochemically euthyroid. Due to decreased echogenicity on ultrasound examination, enhanced vascularization on Color Doppler examination and increased concentration of anti-TSH receptor autoantibodies, she was diagnosed with Graves' disease. Eventually, she underwent total thyroidectomy due to diagnosis of follicular neoplasm in fine-needle aspiration biopsy of the focal lesion found in the thyroid gland. To our knowledge, our patient is the first described with ectopic thyroid, presenting a nodular variant of Graves' disease and no signs of orbitopathy, who was initially hypothyroid and became euthyroid in the course of autoimmune thyroid disease.
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland, ewelinaparulska@gmail.com.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Szczepanek-Parulska
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchala
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Hernik
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D050033:Thyroid Dysgenesis / Q000097:blood* / Q000188:drug therapy; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013956:Antithyroid Agents; D013974:Thyroxine