title: BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas.
abstract: We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.
authors.affiliation: INSERM U827, Montpellier, France. albertina.de-sario@inserm.fr.
authors.forename: Erica
authors.initials: E
authors.lastname: Lana
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Brun
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rivals
authors.forename: Janick
authors.initials: J
authors.lastname: Selves
authors.forename: Sylvain
authors.initials: S
authors.lastname: Kirzin
authors.forename: Andriy P
authors.initials: AP
authors.lastname: Lutsyk
authors.forename: Vasily V
authors.initials: VV
authors.lastname: Gordiyuk
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bibeau
authors.forename: Alla
authors.initials: A
authors.lastname: Rynditch
authors.forename: Albertina
authors.initials: A
authors.lastname: De Sario