title: Triphenylphosphinecarboxamide: an effective reagent for the reduction of azides and its application to nucleic acid detection.
abstract: A series of triphenylphosphinecarboxamide (TPPc) derivatives were designed and synthesized as alternative reagents to triphenylphosphine for the facile reduction of azides. The TPPc derivatives performed as efficient reducing agents for the synthesis of primary amines without the need for an additional hydrolysis procedure. The TPPc derivatives were also applied to nucleic acid sensing using a RhAz-oligonucleotide conjugate in a DNA-templated fluorogenic reaction.
authors.affiliation: Nano Medical Engineering Laboratory, RIKEN, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Saneyoshi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ochikubo
authors.forename: Takushi
authors.initials: T
authors.lastname: Mashimo
authors.forename: Ken
authors.initials: K
authors.lastname: Hatano
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D015394:Molecular Structure; D009696:Nucleic Acids / Q000032:analysis*; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry*; D013730:Terphenyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D001386:Azides; D009696:Nucleic Acids; D010720:Phosphines; D013730:Terphenyl Compounds