title: [Retrospective analysis of effectiveness of intensity-modulated radiotherapy combined with chemotherapy or not for locoregionally advanced nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To analyze the effectiveness and toxicity of intensity-modulated radiotherapy (IMRT) combined with chemotherapy or not for locoregionally advanced nasopharyngeal carcinoma.
  
  
  METHODS
  A total of 226 patients with locoregionally advanced nasopharyngeal carcinoma were retrospectively reviewed and classified into three groups:67 patients treated by radiotherapy alone (RT group), 82 patients by concurrent chemoradiotherapy (CRT group) and 77 patients by cisplatin+5-fluorouracil (PF regimen) combined with CRT (PF+CRT group). All patients using IMRT technique.Outcomes were overall survival, failure patterns, and toxicities.
  
  
  RESULTS
  For the RT, CRT and PF+CRT group, the 5-year overall survival rate was 67.6%, 74% and 71.1% (P = 0.664), respectively; progress-free survival rate 66.9%, 72.6% and 75.6% (P = 0.410); relapse-free survival rate 82.4%, 86.4% and 86.8% (P = 0.447) and distant metastasis-free survival rate 83.8%, 83.8% and 85.8% (P = 0.827). Significantly more grade 3-4 acute toxicities happened in patients treated by chemotherapy (P = 0.002).
  
  
  CONCLUSIONS
  Comparing with IMRT alone, cisplatin-IMRT or PF regimen induction chemotherapy plus cisplatin-IMRT do not significantly improve survival, but increased grade 3-4 acute toxicities.
authors.affiliation: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center,Guangzhou 510060, China.
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Meng-zhong
authors.initials: MZ
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000628:therapy*; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult