title: Effects of metoprolol and nebivolol on exercise blood pressure in patients with mild hypertension.
abstract: OBJECTIVE
  We planned to compare the impact of two beta blockers, metoprolol and nebivolol, on arterial blood pressure during exercise in patients with mild hypertension.
  
  
  METHODS
  A total of 60 patients (13 males, 47 females; mean age: 54.3 ± 10.7 years) were enrolled in the present study. The patients were randomly selected to receive either nebivolol 5 mg/day (n = 30) or metoprolol 50 mg/day (n = 30) for 8 weeks. At the end of the 8th week, each of the patients received exercise stress test according to Bruce protocol and their blood pressures were remeasured after rest, exercise, and recovery.
  
  
  RESULTS
  Blood pressures were determined to be similar between metoprolol and nebivolol groups during rest, exercise, and recovery periods. Metoprolol and nebivolol achieved similar reductions in blood pressures during rest and exercise. However, five patients in nebivolol group and four patients in metoprolol group developed exaggerated BP response to exercise but the difference between metoprolol and nebivolol was not meaningful (P = 0.37).
  
  
  CONCLUSIONS
  The results of the present study showed that metoprolol and nebivolol established comparable effects on the control of blood pressures during exercise in the patients with mild hypertensions.
authors.affiliation: Department of Cardiology, School of Medicine, Eskişehir Osmangazi University, 26000 Eskişehir, Turkey.
authors.forename: Huseyin Ugur
authors.initials: HU
authors.lastname: Yazici
authors.forename: Hande
authors.initials: H
authors.lastname: Ozduman
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Aydar
authors.forename: Alparslan
authors.initials: A
authors.lastname: Birdane
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001578:Benzopyrans / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology*; D004983:Ethanolamines / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D000068577:Nebivolol; D005082:Physical Exertion; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol; D008790:Metoprolol