title: Synthesis of thioamides via one-pot A(3)-coupling of alkynyl bromides, amines, and sodium sulfide.
abstract: We herein describe a novel method for the synthesis of thioamides by a three component condensation of alkynyl bromides, amines, and Na2S·9H2O. The developed method is applicable for a wide range of amines and alkynyl bromides bearing different functional groups furnishing the corresponding products in moderate to excellent yields.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Sun
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
authors.forename: Jianxiao
authors.initials: J
authors.lastname: Li
mesh_terms: D000588:Amines / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D013440:Sulfides / Q000737:chemistry*; D013854:Thioamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D006842:Hydrocarbons, Brominated; D013440:Sulfides; D013854:Thioamides; C033479:sodium sulfide