title: Combined immunodeficiency presenting with vaccine-associated paralytic poliomyelitis: a case report and narrative review of literature.
abstract: Neurologic abnormalities compatible with vaccine-related poliovirus infection (VAPP) may be a first presentation of some primary immunodeficient patients. The risk of VAPP rises from 1 case per 750 000 in normal population to 1 per 7000 times higher, particularly for persons with agammaglobulinemia and hypogammaglobulinemia. However, there is no appropriate estimation for VAPP occurrence in patients with cellular immunity defects. Herein we report a case of combined immunodeficiency with paralytic complication due to oral polio vaccine and we present a literature review on this topic.
authors.affiliation: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science , Tehran , Iran .
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Shaghaghi
authors.forename: Nima
authors.initials: N
authors.lastname: Parvaneh
authors.forename: Pouya
authors.initials: P
authors.lastname: Ostad-Rahimi
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Fathi
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoodi
authors.forename: Hassan
authors.initials: H
authors.lastname: Abolhassani
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
mesh_terms: D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D007223:Infant; D007492:Iran; D018655:Lymphocyte Count; D008297:Male; D010291:Paresis / Q000209:etiology; D010543:Peroneal Nerve / Q000473:pathology / Q000821:virology; D011051:Poliomyelitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D017955:Poliovirus / Q000502:physiology*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects; D012306:Risk; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects
chemical_list: D004279:DNA, Viral; D011055:Poliovirus Vaccine, Oral