title: Clinical features in Guillain-Barré syndrome with anti-Gal-C antibody.
abstract: BACKGROUND
  Guillain-Barré syndrome (GBS) has often been associated with antibodies to glycolipids, such as galactocerebroside (Gal-C), a component of myelin. Whether patients who have GBS with anti-Gal-C antibody (Gal-C-GBS) more often have demyelinating neuropathy or axonal neuropathy remains controversial. Their clinical features have also been unestablished.
  
  
  METHODS
  We enrolled 47 patients with Gal-C-GBS. Their clinical and electrophysiological data were retrospectively reviewed and compared to 119 patients with GBS without anti-Gal-C antibody (non-Gal-C-GBS).
  
  
  RESULTS
  Demyelinating polyneuropathy occurred 4 times more frequently than axonal polyneuropathy in patients with Gal-C-GBS, but without statistical significance compared to patients with non-Gal-C-GBS (2.2:1). Patients with Gal-C-GBS had more frequent sensory deficits, autonomic involvements, and antecedent Mycoplasma pneumoniae (MP) infection than patients with non-Gal-C-GBS.
  
  
  CONCLUSIONS
  This is the largest study clarifying the clinical and electrophysiological findings that more frequent sensory deficits, autonomic involvements, and antecedent MP infection are associated with Gal-C-GBS.
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Samukawa
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Kuwahara
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takada
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan; Department of Neurology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Japan.
authors.forename: Makito
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mitsui
authors.affiliation: Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sonoo
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan. Electronic address: kusunoki-tky@umin.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005699:Galactosylceramides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000209:etiology / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D011019:Pneumonia, Mycoplasma / Q000150:complications; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D005699:Galactosylceramides; C002454:galactocerebroside
keywords: Anti-glycolipid antibody; Axonal neuropathy; Demyelinating neuropathy; Electrophysiological study; Galactocerebroside; Guillain–Barré syndrome; Mycoplasma pneumoniae