title: Attenuation of histopathological alterations of colon, liver and lung by dietary fibre of barley Rihane in azoxymethane-treated rats.
abstract: This study was carried out to determine the effect of dietary fibre (DF) of barley Rihane (BR) in the attenuation of colon, liver and lung histopathology alterations induced by azoxymethane (AOM) in rats. Rats were fed a control (C) or experimental diet containing 30% of BR. The intended rats for cancer treatment received two successive subcutaneous injections of azoxymethane (AOM) at 20mg/kg body weight. The colons were analyzed for crypt multiplicity after 12 weeks of treatment. A histological study of the colon, liver and lungs was determined. The results showed that the BR diet significantly reduced the number of aberrant crypt per focus and altered their distribution. In addition, DF of BR increased significantly the mucus secretion compared to control group. The use of the AOM as colon specific carcinogen substance altered the liver and lung architectures, whereas the presence of DF of BR could be a protective factor for these organs.
authors.affiliation: Unité de Recherche 03/UR/09-01 «Génome, Diagnostic Immunitaire et valorisation», Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, Avenue Tahar Haddad, BP 74, 5000 Monastir, Tunisia. Electronic address: lahouarlamia@yahoo.fr.
authors.forename: Lamia
authors.initials: L
authors.lastname: Lahouar
authors.forename: Fatma
authors.initials: F
authors.lastname: Ghrairi
authors.forename: Amira El
authors.initials: AE
authors.lastname: Arem
authors.forename: Wala
authors.initials: W
authors.lastname: Sghaeir
authors.forename: Mouledi El
authors.initials: ME
authors.lastname: Felah
authors.forename: Hichem Ben
authors.initials: HB
authors.lastname: Salem
authors.forename: Badreddine
authors.initials: B
authors.lastname: Sriha
authors.forename: Lotfi
authors.initials: L
authors.lastname: Achour
mesh_terms: D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003108:Colonic Diseases / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D004043:Dietary Fiber / Q000032:analysis / Q000378:metabolism*; D001467:Hordeum / Q000737:chemistry*; D006801:Humans; D008107:Liver Diseases / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002273:Carcinogens; D004043:Dietary Fiber; D001397:Azoxymethane
keywords: Azoxymethane; Barley Rihane; Colon; Histopathological; Mucus secretion