title: Left ventricular systolic and diastolic function in subjects with a bicuspid aortic valve without significant valvular dysfunction.
abstract: BACKGROUND
  The bicuspid aortic valve (BAV) represents the most common cardiac congenital malformation in adults. It is frequently associated with dilation, aneurysm and dissection of the ascending aorta.
  
  
  OBJECTIVE
  To evaluate left ventricular systolic and diastolic function in subjects with BAVs.
  
  
  METHODS
  Thirty-five subjects with BAV (mean [± SD] age 25.9±5.7 years [range 17 to 36 years]; 18 male, 17 female) with either no valvular impairment or mild valvular impairment were recruited along with 30 control subjects (24.5±4.4 years of age [range 15 to 35 years]; 15 male, 15 female) who were matched for age, sex and body surface area. Left ventricular systolic and diastolic function were evaluated using conventional and tissue Doppler echocardiography. Left ventricular systolic and diastolic parameters were compared between the two groups.
  
  
  RESULTS
  In subjects with BAVs, the ratio of mitral early diastolic velocity to late diastolic velocity was lower (0.95±0.4 versus 1.27±0.9; P=0.001), the ratio of mitral early diastolic velocity to myocardial early diastolic velocity was higher (10.1±3.2 versus 6.5±2.4; P=0.001) and the myocardial early diastolic velocity was lower (8.4±2.1 versus 15.3±3.6; P<0.001) compared with control subjects. In addition, the myocardial performance index was higher in subjects with BAVs than in control subjects (P=0.03). The left ventricular ejection fraction was also lower (53±11% versus 64±13%; P<0.001). No other statistically significant differences were observed between the two groups with regard to left ventricular systolic and diastolic parameters. In addition, the number of mitral valve prolapses and atrial septal aneurysms was higher in subjects with BAVs.
  
  
  CONCLUSIONS
  BAVs may be associated with left ventricular systolic and diastolic dysfunction.
authors.affiliation: Cardiology Department, Bursa Yüksek htisas Education and Research Hospital, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demir
keywords: Atrial septal aneurysm; Bicuspid aortic valve; Cardiomyopathy; Diastolic dysfunction; Systolic dysfunction