title: Yeast hydrolysate can reduce body weight and abdominal fat accumulation in obese adults.
abstract: OBJECTIVE
  The aim of this study was to examine the effect of yeast hydrolysate on the abdominal fat in obese humans.
  
  
  METHODS
  We observed the effects of yeast hydrolysate that had a molecular weight below 10 kDa on the anti-abdominal fat accumulation in obese men and women ages 20 to 50 y for 10 wk. The abdominal fat mass was assessed by computed tomographic scans.
  
  
  RESULTS
  By the sixth week, the reductions in energy intake in the yeast group (yeast hydrolysate 1 g/d) were significantly greater than those in the control group (placebo 1 g/d) (P < 0.05). The body weight and body mass index (BMI) were significantly reduced by week 10 compared with baseline in the yeast group, and these differences were significantly greater than those in the control group: body weight 0.83 kg versus -2.60 k g (P < 0.001), BMI 0.29 kg/m(2) versus -0.90 kg/m(2) (P < 0.001). Despite the increased loss of body weight in the yeast group, lean body mass did not significantly differ between the two groups. Body fat mass in the control group did not significantly change between baseline and week 10. However, the yeast group lost a significant amount of body fat mass after 10 wk of treatment (P < 0.01). The differences in abdominal fat thickness and abdominal circumference between the two groups were significant after 10 wk of treatment (P < 0.001). The total abdominal fat area in the yeast group was significantly lower than in the control group after 10 wk of treatment (-7.06 cm(2) versus -17.34 cm(2); P < 0.01).
  
  
  CONCLUSIONS
  Yeast hydrolysate can reduce body weight and the accumulation of abdominal fat without an adverse effect on lean body mass in obese adults, regardless of sex, via the reduction of energy intake.
authors.affiliation: Department of Home Economic Education, Jeonju University, Jeonju, Republic of Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Jung
authors.forename: Mi Kyoung
authors.initials: MK
authors.lastname: Cho
authors.forename: Yang-Hee
authors.initials: YH
authors.lastname: Hong
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Yooheon
authors.initials: Y
authors.lastname: Park
authors.forename: Un Jae
authors.initials: UJ
authors.lastname: Chang
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D011492:Protein Hydrolysates / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects*; D015003:Yeasts / Q000737:chemistry*; D055815:Young Adult
chemical_list: D011492:Protein Hydrolysates
keywords: Abdominal fat; Body weight; Computed tomography; Obesity