title: Intralesional bleomycin sclerotherapy in childhood lymphangioma.
abstract: This clinical trial was conducted to evaluate the efficacy of intralesional bleomycin sclerotherapy (IBS) in children with lymphangioma and to determine the incidence of complications in the treatment. Seventeen lymphangioma cases were treated with IBS from 2004 to 2012. Age, mode of presentation, locations and types of lesions, and results of treatment were studied. Lymphangioma was diagnosed by physical examination and imaging studies. Most of the lesions were located in the cervical region (n=8) and of macrocystic type (n=13). After the first injection, three patients were lost to follow-up. Good response was seen in 50% of the lesions, complete resolution in 35.7%, and poor response in 14.3%. No serious complications or side effects were observed after IBS. The average follow-up was 18.5 months. IBS is effective in the treatment of lymphangioma. Although no major adverse effects have been encountered, complications should be kept in mind and in the event of their occurrence be treated immediately.
authors.affiliation: Department of Pediatric Surgery, Dr. Behçet Uz Children's Hospital, İzmir, Turkey. verikci@yahoo.com.
authors.forename: Volkan
authors.initials: V
authors.lastname: Erikçi
authors.forename: Münevver
authors.initials: M
authors.lastname: Hoşgör
authors.forename: Melih
authors.initials: M
authors.lastname: Yıldız
authors.forename: Yılmazcan
authors.initials: Y
authors.lastname: Örnek
authors.forename: Nail
authors.initials: N
authors.lastname: Aksoy
authors.forename: Özkan
authors.initials: Ö
authors.lastname: Okur
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Demircan
authors.forename: İncinur
authors.initials: İ
authors.lastname: Genişol
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008202:Lymphangioma / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D015911:Sclerotherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin