title: A novel site comes into sight.
abstract: Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
authors.affiliation: Yu Wang is at the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China and the School of Pharmacy, University of Wisconsin, Madison, United States yuwang@post.harvard.edu.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
mesh_terms: D000818:Animals; D053823:Hedgehog Proteins / Q000737:chemistry*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D000072086:Smoothened Receptor; D013261:Sterols / Q000737:chemistry*; D015027:Zebrafish / Q000235:genetics*; D029961:Zebrafish Proteins / Q000737:chemistry*
chemical_list: D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; D000072086:Smoothened Receptor; D013261:Sterols; D029961:Zebrafish Proteins; C491021:smo protein, zebrafish
keywords: Hedgehog signaling; cysteine rich domain; oxysterol; smoothened