title: Human induced pluripotent stem cells from basic research to potential clinical applications in cancer.
abstract: The human induced pluripotent stem cells (hiPSCs) are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors. These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body. So, the discovery of hiPSCs opens new opportunities in biomedical sciences, since these cells may be useful for understanding the mechanisms of diseases in the production of new diseases models, in drug development/drug toxicity tests, gene therapies, and cell replacement therapies. However, the hiPSCs technology has limitations including the potential for the development of genetic and epigenetic abnormalities leading to tumorigenicity. Nowadays, basic research in the hiPSCs field has made progress in the application of new strategies with the aim to enable an efficient production of high-quality of hiPSCs for safety and efficacy, necessary to the future application for clinical practice. In this review, we show the recent advances in hiPSCs' basic research and some potential clinical applications focusing on cancer. We also present the importance of the use of statistical methods to evaluate the possible validation for the hiPSCs for future therapeutic use toward personalized cell therapies.
authors.affiliation: National Cancer Institute (INCA), Bone Marrow Transplantation Center (CEMO), Laboratory Division, 20230-130 Rio de Janeiro, RJ, Brazil.
authors.forename: Teresa de Souza
authors.initials: Tde S
authors.lastname: Fernandez
authors.forename: Cecilia
authors.initials: C
authors.lastname: de Souza Fernandez
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Mencalha
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D044127:Epigenesis, Genetic; D015316:Genetic Therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009369:Neoplasms / Q000628:therapy*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors