title: Huge Bowen's disease: a pitfall of topical photodynamic therapy.
abstract: Bowen's disease (BD) is one of the major histological types of nonmelanoma skin cancer. With challengeable "multiple and large" patches of BD, topical photodynamic therapy (PDT) has been considered as a first-line effective modality for decades. However, there was no general consensus among authors about the definition of "large BD". Herein, we have experienced two cases of huge BD which has over 10 cm in diameter with resistance to topical PDT. Our cases suggest that topical PDT is likely to show a much less satisfactory effect for huge BD than we have expected, and the previously specified indication of topical PDT ("multiple, larger lesion") seems the fallacy of hasty generalization. Therefore, it is required that further cut-off value of size for suitable candidate for topical PDT would be clarified.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Park
authors.forename: Sue Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: You Chan
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D017211:Treatment Failure; D047368:Tumor Burden
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: Bowen's disease; Photodynamic therapy