title: The effect of relaxin on the musculoskeletal system.
abstract: Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: F
authors.initials: F
authors.lastname: Dehghan
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: B S
authors.initials: BS
authors.lastname: Haerian
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Muniandy
authors.affiliation: Department of Physiology, Sports Center, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Yusof
authors.affiliation: Department of Orthopaedic Surgery, Stanford University, Redwood City, California, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Dragoo
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Salleh
mesh_terms: D001842:Bone and Bones / Q000502:physiology; D002356:Cartilage / Q000502:physiology; D006801:Humans; D008022:Ligaments / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D012065:Relaxin / Q000502:physiology*; D015398:Signal Transduction; D013583:Synovial Membrane / Q000502:physiology; D013710:Tendons / Q000502:physiology
chemical_list: D012065:Relaxin
keywords: ligament; motor organs; relaxin; skeletal muscle; tendon