title: Prediction and verification of nonlinear sleep spindle harmonic oscillations.
abstract: This paper examines nonlinear effects in a neural field model of the corticothalamic system to predict the EEG power spectrum of sleep spindles. Nonlinearity in the thalamic relay nuclei gives rise to a spindle harmonic visible in the cortical EEG. By deriving an analytic expression for nonlinear spectrum, the power in the spindle harmonic is predicted to scale quadratically with the power in the spindle oscillation. By isolating sleep spindles from background sleep in experimental EEG data, the spindle harmonic is directly observed.
authors.affiliation: School of Physics, University of Sydney, New South Wales 2006, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, New South Wales 2145, Australia; Center for Integrated Research and Understanding of Sleep, Glebe, New South Wales 2037, Australia. Electronic address: r.abeysuriya@physics.usyd.edu.au.
authors.forename: R G
authors.initials: RG
authors.lastname: Abeysuriya
authors.affiliation: School of Physics, University of Sydney, New South Wales 2006, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, New South Wales 2145, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Rennie
authors.affiliation: School of Physics, University of Sydney, New South Wales 2006, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, New South Wales 2145, Australia; Center for Integrated Research and Understanding of Sleep, Glebe, New South Wales 2037, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D017711:Nonlinear Dynamics; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology*; D013788:Thalamus / Q000502:physiology
keywords: EEG; Neural field theory; Neurophysiology