title: Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989-2010.
abstract: The temporal trend in serum concentrations of phenolic organohalogen contaminants (POCs) were investigated in two age groups of men from Kyoto, Japan, from 1989 to 2010. These concentrations and trends were compared with neutral contaminants including polychlorinated biphenyls (PCBs) and pesticides. Serum concentrations of pentachlorophenol (PenCP) and 4-hydroxy-PCB187 were age-dependent and decreased to approximately one-half during the two decades, whereas no contamination trends were observed for 2,4,6-tribromophenol (TriBP), tetrabromobisphenol A (TBBPA) and 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE47). 6-OH-BDE47 was found in all samples (up to 3000 pg/g wet weight), whereas TBBPA was detected in 17 of 60 serum samples (up to 950 pg/g wet weight). The concentrations of TriBP, TBBPA and 6-OH-BDE47 were not correlated to those of PenCP or 4-OH-PCB187 in either age group, suggesting the different kinetics on exposure routes and fate between these brominated and chlorinated POCs.
authors.affiliation: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Fujii
authors.affiliation: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
authors.forename: Kouji H
authors.initials: KH
authors.lastname: Harada
authors.affiliation: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hitomi
authors.affiliation: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
authors.forename: Hatasu
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Koizumi
authors.affiliation: Daiichi College of Pharmaceutical Sciences, Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Electronic address: k-haraguti@daiichi-cps.ac.jp.
authors.forename: Koichi
authors.initials: K
authors.lastname: Haraguchi
mesh_terms: D000328:Adult; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000097:blood*; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000097:blood*; D007564:Japan; D008297:Male; D008875:Middle Aged; D010416:Pentachlorophenol / Q000097:blood; D010575:Pesticides / Q000097:blood; D010636:Phenols / Q000097:blood*; D011075:Polybrominated Biphenyls / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000097:blood; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006846:Hydrocarbons, Halogenated; D010575:Pesticides; D010636:Phenols; D011075:Polybrominated Biphenyls; C511295:2,2',4,4'-tetrabromodiphenyl ether; D010416:Pentachlorophenol; D011078:Polychlorinated Biphenyls; C020806:tetrabromobisphenol A
keywords: 6-Hydroxy-BDE47; Human exposure; Phenolic organohalogen; Serum; Tetrabromobisphenol A