title: Building synthetic cellular organization.
abstract: The elaborate spatial organization of cells enhances, restricts, and regulates protein-protein interactions. However, the biological significance of this organization has been difficult to study without ways of directly perturbing it. We highlight synthetic biology tools for engineering novel cellular organization, describing how they have been, and can be, used to advance cell biology.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Polka
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Silver
mesh_terms: D058045:Artificial Cells / Q000378:metabolism*; D008954:Models, Biological; D013347:Subcellular Fractions / Q000378:metabolism; D058615:Synthetic Biology / Q000379:methods*