title: A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012.
abstract: A total of 165 sporotrichosis cases occurring in Nagasaki prefecture, and examined at Nagasaki University Hospital, were evaluated. Both males and females were equally affected, with no significant differences in the affected body regions. Lesions were frequently seen on the face (49 cases, 29.5%) and upper limbs (101 cases, 60.9%). The localised cutaneous type of sporotrichosis (105 cases, 62.9%) was much more frequent than the lymphocutaneous type (62 cases, 37.1%). The infection rate in patients over 50 years of age was 73.1%. The most frequent occupation among the patients was farming (52 cases, 37.4%), and 34 patients had a history of injury. Regarding the geographical distribution of sporotrichosis, 48 cases occurred in the Shimabara peninsula (31.2%) and this is much higher than expected for the population size. Before 1994, almost all sporotrichosis cases (112 cases, 96.5%) were treated with potassium iodide (KI). After 1995, the number of patients treated with KI decreased (nine cases, 23.1%), and itraconazole (ITZ) was used in 21 cases (59.0%) and terbinafine in six cases (15.3%). The time between ITZ and KI treatment and cure was 13.8 weeks and 12.5 weeks, respectively. All 116 cases, for which the outcome was known, were cured or improved.
authors.affiliation: Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Takenaka
authors.forename: Asako
authors.initials: A
authors.lastname: Yoshizaki
authors.forename: Atushi
authors.initials: A
authors.lastname: Utani
authors.forename: Katsutaro
authors.initials: K
authors.lastname: Nishimoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D013175:Sporothrix / Q000235:genetics / Q000302:isolation & purification*; D013174:Sporotrichosis / Q000175:diagnosis* / Q000188:drug therapy / Q000266:history / Q000382:microbiology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents
keywords: Nagasaki prefecture; Sporotrichosis; geographical distribution; survey; treatment