title: 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.
abstract: A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their ketone intermediates and indomethacin. The NO-donating oximes 7i and 7k achieved remarkable cell growth inhibition activity against most of the tested cell lines. Compound 7k was found to be with high selectivity against CNS subpanel with selectivity ratio of 11.99 at GI₅₀ level.
authors.affiliation: Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
authors.forename: Gamal El-Din A A
authors.initials: Gel-D
authors.lastname: Abuo-Rahma
authors.affiliation: Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: abulnil@hotmail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Aziz
authors.affiliation: Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
authors.forename: Eman A M
authors.initials: EA
authors.lastname: Beshr
authors.affiliation: Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
authors.forename: Taha F S
authors.initials: TF
authors.lastname: Ali
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D020030:Nitric Oxide Donors / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D010091:Oximes / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D014230:Triazoles / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D020030:Nitric Oxide Donors; D010091:Oximes; D014230:Triazoles; C045575:1,2,4-triazole
keywords: 1,2,4-Triazole; Anti-inflammatory; Antiproliferative; Nitric oxide donors; Ulcerogenicity