title: Multimodal instrument for high-sensitivity autofluorescence and spectral optical coherence tomography of the human eye fundus.
abstract: In this paper we present a multimodal device for imaging fundus of human eye in vivo which combines functionality of autofluorescence by confocal SLO with Fourier domain OCT. Native fluorescence of human fundus was excited by modulated laser beam (λ = 473 nm, 20 MHz) and lock-in detection was applied resulting in improving sensitivity. The setup allows for acquisition of high resolution OCT and high contrast AF images using fluorescence excitation power of 50-65 μW without averaging consecutive images. Successful functioning of constructed device have been demonstrated for 8 healthy volunteers of different age ranging from 24 to 83 years old.
authors.affiliation: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun, Poland ; authors contributed equally to presented work.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Komar
authors.forename: Patrycjusz
authors.initials: P
authors.lastname: Stremplewski
authors.forename: Marta
authors.initials: M
authors.lastname: Motoczyńska
authors.forename: Maciej
authors.initials: M
authors.lastname: Szkulmowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Wojtkowski
keywords: (110.0110) Imaging systems; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography; (170.5755) Retina scanning; (170.6280) Spectroscopy, fluorescence and luminescence