title: Disarray of glomerular and tubular cell adhesion molecules in the course of experimental Bothrops moojeni envenomation.
abstract: In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury.
authors.affiliation: Department of Histology and Embryology, Institute of Biology, P.O. Box 6109, State University of Campinas (UNICAMP), 13 087-130 Campinas, SP, Brazil.
authors.forename: Carla Beatriz
authors.initials: CB
authors.lastname: Collares-Buzato
authors.affiliation: Department of Histology and Embryology, Institute of Biology, P.O. Box 6109, State University of Campinas (UNICAMP), 13 087-130 Campinas, SP, Brazil. Electronic address: hofling@unicamp.br.
authors.forename: Maria Alice
authors.initials: MA
authors.lastname: da Cruz-Höfling
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D017837:Bothrops / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects*; D003435:Crotalid Venoms / Q000633:toxicity*; D005109:Extracellular Matrix / Q000187:drug effects*; D019084:Fluorescent Antibody Technique, Indirect; D019012:Integrin beta1 / Q000378:metabolism; D007678:Kidney Glomerulus / Q000187:drug effects*; D007684:Kidney Tubules / Q000187:drug effects*; D007797:Laminin / Q000378:metabolism; D051381:Rats; D012909:Snake Bites / Q000473:pathology*; D016596:Vinculin / Q000378:metabolism; D062826:Zonula Occludens-1 Protein / Q000378:metabolism
chemical_list: D000199:Actins; D003435:Crotalid Venoms; D019012:Integrin beta1; D007797:Laminin; C569044:Tjp1 protein, rat; D062826:Zonula Occludens-1 Protein; D016596:Vinculin
keywords: Acute kidney injury; Bothropic envenomation; Cell adhesion proteins; Cytoskeletal proteins; Glomerular injury; Nephron tubular injury