title: Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?
abstract: After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.
authors.affiliation: Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
authors.forename: Nazish
authors.initials: N
authors.lastname: Sayed
authors.forename: Wing Tak
authors.initials: WT
authors.lastname: Wong
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
mesh_terms: D054338:Cell Transdifferentiation; D002921:Cicatrix / Q000473:pathology*; D006331:Heart Diseases / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D032383:Myocytes, Cardiac / Q000473:pathology*; D044968:Regenerative Medicine / Q000379:methods*
keywords: cardiomyocytes; cardiovascular diseases; cardiovascular regeneration; transdifferentiation; transflammation