title: Application of computational lower extremity model to investigate different muscle activities and joint force patterns in knee osteoarthritis patients during walking.
abstract: Many experimental and computational studies have reported that osteoarthritis in the knee joint affects knee biomechanics, including joint kinematics, joint contact forces, and muscle activities, due to functional restriction and disability. In this study, differences in muscle activities and joint force patterns between knee osteoarthritis (OA) patients and normal subjects during walking were investigated using the inverse dynamic analysis with a lower extremity musculoskeletal model. Extensor/flexor muscle activations and torque ratios and the joint contact forces were compared between the OA and normal groups. The OA patients had higher extensor muscle forces and lateral component of the knee joint force than normal subjects as well as force and torque ratios of extensor and flexor muscles, while the other parameters had little differences. The results explained that OA patients increased the level of antagonistic cocontraction and the adduction moment on the knee joint. The presented findings and technologies provide insight into biomechanical changes in OA patients and can also be used to evaluate the postoperative functional outcomes of the OA treatments.
authors.affiliation: Department of Orthopaedic Surgery, Inje University, Ilsan Paik Hospital, Ilsan 441-706, Republic of Korea.
authors.forename: Kyung Wook
authors.initials: KW
authors.lastname: Nha
authors.forename: Ariunzaya
authors.initials: A
authors.lastname: Dorj
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Shin
authors.forename: Jong In
authors.initials: JI
authors.lastname: Kim
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Kwon
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Kim
authors.forename: Yoon Hyuk
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D005684:Gait / Q000502:physiology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007719:Knee Joint / Q000503:physiopathology; D007866:Leg / Q000503:physiopathology; D008875:Middle Aged; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D016138:Walking / Q000502:physiology*