title: Hepatitis C treatment with triple therapy in a patient with hemophilia A.
abstract: We report a case of successful treatment of chronic hepatitis C infection with telaprevir-based triple therapy in a patient with hemophilia A complicated by factor VIII inhibitor. A twenty-two years old male with hereditary hemophilia A and high-titer factor VIII inhibitor was taking maintenance doses of recombinant factor VIII. He visited our clinic for treatment of his chronic hepatitis C with the newly instituted protease inhibitor based therapy. He was diagnosed with hepatitis C genotype 1a at one year of age. He was initiated on telaprevir, ribavirin and peg-interferon for treatment of hepatitis C and qualified for response-guided therapy. He completed treatment at 24 wk with minimal adverse effects. Notably, after 4 wk of hepatitis C treatment, his factor VIII inhibitor screen was negative and the dose for recombinant factor VIII decreased by half of the initial dosing before he was treated for hepatitis C. We suspect that suppressing hepatitis C may help decrease factor VIII inhibitor level and the need for recombinant factor VIII.
authors.affiliation: Gurshawn Singh, Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
authors.forename: Gurshawn
authors.initials: G
authors.lastname: Singh
authors.forename: Reuben
authors.initials: R
authors.lastname: Sass
authors.forename: Rayan
authors.initials: R
authors.lastname: Alamiry
authors.forename: Nizar
authors.initials: N
authors.lastname: Zein
authors.forename: Naim
authors.initials: N
authors.lastname: Alkhouri
keywords: Factor VIII; Factor VIII inhibitor; Hemophilia; Hepatitis C virus; Protease inhibitor; Telaprevir