title: Dilated papilla with mucin extrusion is a potential predictor of acute pancreatitis associated with intraductal papillary mucinous neoplasms of pancreas.
abstract: OBJECTIVE
  As intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, predicting the risk of pancreatitis is as important as predicting the risk of malignancy in IPMN cases. In this study, we attempted to clarify the characteristics of IPMN associated with AP, compared to those of IPMN not associated with AP.
  
  
  METHODS
  From January 2006 to March 2013, data from 88 patients who underwent surgery for IPMN were retrospectively investigated and analyzed. We evaluated clinical and pathological variables of each patient and compared patients with IPMN with AP to those without AP. Furthermore, we presented representative cases of mild and severe pancreatitis caused by IPMN.
  
  
  RESULTS
  Overall, 12 of 88 patients with IPMN (13.6%) had AP. Seven of the 12 patients had a single episode of AP, whereas the remaining 5 patients were diagnosed with IPMN with repeated AP. Ten of 12 patients with AP were diagnosed with mild AP and the remaining 2 with severe AP. Regarding clinical findings, the proportion of dilated papilla with mucin extrusion was significantly higher in patients with IPMN with AP than in those without AP (p = 0.035). Histological findings indicated that the proportion of intestinal-subtype IPMN was significantly higher in patients with IPMN with AP (p = 0.013).
  
  
  CONCLUSIONS
  AP caused by IPMN derives mostly from intestinal IPMN. Dilated papilla with mucin extrusion can be a potential predictor of AP.
authors.affiliation: Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hata
authors.forename: Naoaki
authors.initials: N
authors.lastname: Sakata
authors.forename: Takaho
authors.initials: T
authors.lastname: Okada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Yu
authors.initials: Y
authors.lastname: Katayose
authors.forename: Shinichi
authors.initials: S
authors.lastname: Egawa
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010195:Pancreatitis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018300:Papilloma, Intraductal / Q000150:complications* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D009077:Mucins
keywords: Acute pancreatitis; Intraductal papillary mucinous neoplasm (IPMN); Papilla of Vater