title: Catheterization diastolic pressures correlate with diastolic dyssynchrony in patients with single right ventricles.
abstract: BACKGROUND
  Diastolic dyssynchrony has correlated with pulmonary capillary wedge pressures in patients with normal cardiac anatomy. No data exist in single right ventricle (sRV) patients. Goal of this study was to determine if diastolic dyssynchrony in sRV patients correlates with ventricular end-diastolic pressures (VEDP).
  
  
  METHODS
  Tissue Doppler imaging (TDI) and strain rate (SR) analysis of sRV patients undergoing catheterization were performed. Time interval from onset of QRS to peak TDI e'-wave was obtained. Differences in intervals were calculated: QRS (RV) - QRS (IVS) and QRS (RV) - QRS (LV). Time interval from onset of QRS to peak strain rate early diastolic wave (SRe) was obtained for the 6 segment model sRV. Standard deviation of the 6 SRe time intervals was calculated. Correlation of VEDP with timing intervals was analyzed.
  
  
  RESULTS
  Forty sRV patients were evaluated. Age was 2.8 ± 3.5 years. Catheterization VEDP of the sRV was 9.3 ± 3.9 mmHg (median 8 mmHg range 4-24 mmHg). QRS (RV) - QRS (IVS) was 22.3 ± 18.1 msec and QRS (RV) - QRS (LV) was 23.7 ± 19.0 msec. SRe standard deviation of the sRV was 61.6 ± 23.9 msec. There was no significant correlation with VEDP and QRS (RV) - QRS (IVS) (r = 0.1, P = NS) or with QRS (RV) - QRS (LV) (r = 0.2, P = NS). There was a significant correlation of VEDP with the SRe standard deviation value (r = 0.4, P < 0.05).
  
  
  CONCLUSIONS
  Diastolic dyssynchrony correlated with VEDP in patients with sRV physiology. Future studies are needed to determine the significance of these findings.
authors.affiliation: Heart Center, Nationwide Children's Hospital, Columbus, Ohio.
authors.forename: Corey
authors.initials: C
authors.lastname: Stiver
authors.forename: Janaki
authors.initials: J
authors.lastname: Gokhale
authors.forename: Nazia
authors.initials: N
authors.lastname: Husain
authors.forename: Lisa
authors.initials: L
authors.lastname: Nicholson
authors.forename: Joyce
authors.initials: J
authors.lastname: Cordier
authors.forename: Lindsey
authors.initials: L
authors.lastname: Van Lente
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Holzer
authors.forename: Clifford L
authors.initials: CL
authors.lastname: Cua
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006352:Heart Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008297:Male; D015588:Observer Variation; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology*
keywords: catheterization; congenital heart disease; diastole; dyssynchrony; echocardiography