title: Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan.
abstract: A novel bilayered mucoadhesive buccal patch of zolmitriptan was prepared using xanthan gum (XG) as mucoadhesive polymer. Hydroxypropyl methylcellulose E-15 was used as film-former and polyvinyl alcohol (PVA) was incorporated, to increase the tensile strength of the patches. To study the effect of independent variables viz. concentrations of XG and PVA, on various dependent variables like in vitro drug release, ex vivo mucoadhesive strength and swelling index, 3(2) factorial design was employed. In vitro drug release studies of optimized formulation showed initially, rapid drug release; 43.15% within 15 min, followed by sustained release profile over 5h. Incorporation of 4% dimethyl sulfoxide enhanced drug permeability by 3.29 folds, transported 29.10% of drug after 5h and showed no buccal mucosal damage after histopathological studies. In conclusion, XG can be used as a potential drug release modifier and mucoadhesive polymer for successful formulation of zolmitriptan buccal patches.
authors.affiliation: Department of Pharmaceutics, Sinhgad Technical Education Society's, Sinhgad Institute of Pharmacy, Narhe, Pune 411041, Maharashtra, India. Electronic address: rewathishiledar@gmail.com.
authors.forename: Rewathi R
authors.initials: RR
authors.lastname: Shiledar
authors.forename: Amol A
authors.initials: AA
authors.lastname: Tagalpallewar
authors.forename: Chandrakant R
authors.initials: CR
authors.lastname: Kokare
mesh_terms: D000268:Adhesiveness; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D009061:Mouth Mucosa / Q000378:metabolism; D023303:Oxazolidinones / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013499:Surface Properties; D013718:Tensile Strength; D013997:Time Factors; D014363:Tryptamines / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D023303:Oxazolidinones; D011135:Polysaccharides, Bacterial; D014363:Tryptamines; C089750:zolmitriptan; C002563:xanthan gum
keywords: 3(2) factorial design; Bilayered; Xanthan gum; Zolmitriptan