title: Non-lithographic patterning of phage-displayed peptides with wrinkled elastomers.
abstract: The development of controlled patterning of phage (viruses) could expand opportunities for both fundamental studies and creating various materials platforms. Inducing the elastomeric instability of PDMS film provides a non-lithographic, tuneable, controlled method for generating micro/nanoscale wrinkle patterns. Phage display has emerged as a powerful method for selecting peptides that possess enhanced selectivity and binding affinity toward a variety of targets. In this report, we demonstrate the non-lithographic patterning of phage-displayed peptides with wrinkled elastomers. Our results show that the phage-displayed peptides can be patterned on specific locations in controlled and tuneable ways, be transferred to other substrates and induce the self-assembly of hybrid materials. We anticipate that these results could open up exciting opportunities in fundamental studies and in applications ranging from sensors, hybrid materials, self-assembly, surface and interface, to micro/nanoelectronics.
authors.affiliation: Department of Biological Engineering, Utah State University, , Logan, UT 84322, USA.
authors.forename: Swathi
authors.initials: S
authors.lastname: Swaminathan
authors.forename: Mitchell
authors.initials: M
authors.lastname: Bullough
authors.forename: Qifei
authors.initials: Q
authors.lastname: Li
authors.forename: Anhong
authors.initials: A
authors.lastname: Zhou
authors.forename: Yue
authors.initials: Y
authors.lastname: Cui
mesh_terms: D004129:Dimethylpolysiloxanes / Q000737:chemistry; D020724:Elastomers / Q000737:chemistry; D004926:Escherichia coli / Q000378:metabolism; D005898:Glass; D053768:Metal Nanoparticles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004129:Dimethylpolysiloxanes; D020724:Elastomers; D019151:Peptide Library; D010455:Peptides; D012834:Silver; C013830:baysilon; D012822:Silicon Dioxide
keywords: non-lithographic patterning; phage-displayed peptides; self-assembly; wrinkle patterns