title: Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts.
abstract: Asymmetric hydrogenation of alkenes is one of the most widely used methods for the preparation of single enantiomer compounds, especially in the pharmaceutical and agrochemical industries. For more than four decades, precious metal complexes containing rhodium, iridium, and ruthenium have been predominantly used as catalysts. Here, we report rapid evaluation of libraries of chiral phosphine ligands with a set of simple cobalt precursors. From these studies, base metal precatalysts have been discovered for the hydrogenation of functionalized and unfunctionalized olefins with high enantiomeric excesses, demonstrating the potential utility of more earth-abundant metals in asymmetric hydrogenation.
authors.affiliation: Department of Chemistry, Princeton University, Princeton, NJ 08540, USA.
authors.forename: Max R
authors.initials: MR
authors.lastname: Friedfeld
authors.forename: Michael
authors.initials: M
authors.lastname: Shevlin
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Hoyt
authors.forename: Shane W
authors.initials: SW
authors.lastname: Krska
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Tudge
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Chirik
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D006865:Hydrogenation; D008024:Ligands; D010720:Phosphines / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000032:analysis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D008024:Ligands; D010720:Phosphines; D054852:Small Molecule Libraries; D003035:Cobalt