title: Encapsulation altered starch digestion: toward developing starch-based delivery systems.
abstract: Starch is an abundant biomaterial that forms a vital energy source for humans. Altering its digestion, e.g. increasing the proportions of slowly digestible starch (SDS) and resistant starch (RS), would revolutionize starch utility in addressing a number of health issues related to glucose absorption, glycemic index and colon health. The research reported in this article is based on my hypothesis that water channels present in the B-type starch crystalline matrix, particularly in tuber starches, can embed guest molecules such as nutraceuticals, drugs, flavor compounds and vitamins leading to altered starch digestion. Toward this goal, potato starch has been chosen as the model tuber starch, and ibuprofen, benzocaine, sulfapyridine, curcumin, thymol and ascorbic acid as model guest molecules. X-ray powder diffraction and FT-IR analyses clearly suggest the incorporation of guest molecules in the water channels of potato starch. Furthermore, the in vitro digestion profiles of complexes are intriguing with major variations occurring after 60 min of starch digestion and finally at 120 min. These changes are concomitantly reflected in the SDS and RS amounts, with about 24% decrease in SDS for benzocaine complex and 6% increase in RS for ibuprofen complex, attesting the ability of guest molecule encapsulation in modulating the digestion properties of potato starch. Overall, this research provides an elegant opportunity for the design and development of novel starch-based stable carriers that not only bestow tailored glucose release rates but could also transport health promoting and disease preventing compounds.
authors.affiliation: Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907-2009, USA. Electronic address: janaswam@purdue.edu.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Janaswamy
mesh_terms: D002214:Capsules; D004063:Digestion; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D013213:Starch / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002214:Capsules; D004337:Drug Carriers; D013213:Starch
keywords: Delivery; Encapsulation; FT-IR; Starch; X-ray diffraction