title: Detection of single nanoparticles and lentiviruses using microcavity resonance broadening.
abstract: A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.
authors.forename: Linbo
authors.initials: L
authors.lastname: Shao
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Jiang
authors.forename: Xiao-Chong
authors.initials: XC
authors.lastname: Yu
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Li
authors.forename: William R
authors.initials: WR
authors.lastname: Clements
authors.forename: Frank
authors.initials: F
authors.lastname: Vollmer
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Xiao
authors.forename: Qihuang
authors.initials: Q
authors.lastname: Gong
mesh_terms: D016086:Lentivirus / Q000302:isolation & purification*; D055616:Microtechnology / Q000379:methods*; D053758:Nanoparticles / Q000032:analysis*