title: Effects of naltrexone on firing activity of rat cortex neurons and its interactions with ethanol.
abstract: Naltrexone dose-dependently decreased neuron firing rate in the rat frontal cortex after intravenous (1-20 mg/kg) and microelectrophoretic administration. Microelectrophoretic applications of naltrexone reduced the excitatory neuronal response of neurons to low doses of ethanol (electroosmotic application) and potentiated depression of firing activity induced by ethanol in high doses. We concluded that opioid peptides take part in generation of spontaneous neuronal activity in the frontal cortex and neuronal excitation caused by ethanol in low doses. Naltrexone acts as a synergist of ethanol in its depressive effect on cortical neurons.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia. tunetuga@mail.ru.
authors.forename: S N
authors.initials: SN
authors.lastname: Kozhechkin
authors.forename: Yu S
authors.initials: YS
authors.lastname: Mednikova
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004357:Drug Synergism; D053841:Electroosmosis; D004586:Electrophoresis; D000431:Ethanol / Q000494:pharmacology*; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D008839:Microelectrodes; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques
chemical_list: D009292:Narcotic Antagonists; D000431:Ethanol; D009271:Naltrexone