title: Curcumin glucuronides: assessing the proliferative activity against human cell lines.
abstract: A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Pal
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Bokyung
authors.initials: B
authors.lastname: Sung
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Basvoju A
authors.initials: BA
authors.lastname: Bhanu Prasad
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Schuber
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Sahdeo
authors.initials: S
authors.lastname: Prasad
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: wbornmann@mdanderson.org.
authors.forename: William G
authors.initials: WG
authors.lastname: Bornmann
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003474:Curcumin / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D013329:Structure-Activity Relationship
chemical_list: D003474:Curcumin
keywords: Curcumin; Curcumin di-glucuronides; Curcumin mono-glucuronide; ISDDQQPRTHCEGT-XANUIUACSA-N; JCAFLHUESYYNFH-NMQQATKUSA-N; ZIUSSTSXXLLKKK-KOBPDPAPSA-N