title: Ionic liquid-supported synthesis of piperazine derivatives as potential insecticides.
abstract: With the purpose of extending our efforts on the search and synthesis of new insecticides with novel acting modes, a series of novel 4-(2-(4-(pyridin-2-yl)piperazin-1-yl)ethoxy)aniline derivatives were designed based on classical serotonin receptor ligands and synthesized through the rapid ionic liquid-supported parallel synthesis with yields up to 88 %. These products were purified through the convenient washing with appropriate solvents and isolated in good yield. In addition, 27 amide or urea derivatives of anilines were also prepared. Bioassay data showed that some of the synthesized compounds displayed selective insecticidal bioactivities against tested pests.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai,  200237, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Wang
authors.forename: Gong-Hua
authors.initials: GH
authors.lastname: Song
mesh_terms: D060326:Chemistry Techniques, Synthetic; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D052578:Ionic Liquids / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism
chemical_list: D007306:Insecticides; D052578:Ionic Liquids; D010879:Piperazines; D011985:Receptors, Serotonin; D000077489:Piperazine