title: Reactive thrombocytosis in children.
abstract: The aim of this study was to evaluate the causes of thrombocytosis, which was defined as a platelet count greater than 500 x 10(9)/L, and to compare the groups with mild and severe thrombocytosis. A total of 484 patients were evaluated for the etiology of thrombocytosis. Patients with a platelet count between 500-800 x 10(9)/L were considered to have mild thrombocytosis, while those with a count of ≥800 x 10(9)/L were considered as having severe thrombocytosis. Of 484 patients included, 63% had thrombocytosis due to an infectious disease, 11.4% had a chronic inflammatory condition, 8.5% had anemia, and 5.2% had tissue injury. The frequency of chronic inflammation was higher in the severe thrombocytosis group compared to the mild thrombocytosis group (p=0.006). In conclusion, severe infections and chronic inflammatory conditions should be considered in the differential diagnosis of a patient with severe thrombocytosis.
authors.affiliation: Department of Pediatrics, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey. celalozcan01@yahoo.com.tr.
authors.forename: Celal
authors.initials: C
authors.lastname: Özcan
authors.forename: Tülin Revide
authors.initials: TR
authors.lastname: Şaylı
authors.forename: Vildan
authors.initials: V
authors.lastname: Koşan-Çulha
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000150:complications*; D007249:Inflammation / Q000150:complications*; D008297:Male; D010976:Platelet Count; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*