title: (+)- and (-)-Cajanusine, a pair of new enantiomeric stilbene dimers with a new skeleton from the leaves of Cajanus cajan.
abstract: A pair of new enantiomeric stilbene dimers, (+)- and (-)-cajanusine [(+)-1 and (-)-1], with a unique coupling pattern were isolated from the leaves of Cajanus cajan . Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of 1 was also proposed. Additionally, (±)-1, (+)-1, and (-)-1 exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Li
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Zhao
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Li
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Jian
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds; D036561:Cajanus / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry*; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001643:Bridged Bicyclo Compounds; D013267:Stilbenes; C588102:cajanusine