title: Effect of telomere length on prognosis in men with acute coronary syndrome.
abstract: Telomere length is related to cellular aging and cardiovascular disease. Nevertheless, the specific role of cellular aging in this process is still unclear. The aim of this report was to analyze the prognostic value of telomere length in men admitted for acute coronary syndrome. Telomere length was measured by quantitative polymerase chain reaction in peripheral blood leukocytes of 203 men classified into 2 groups: those aged 50 to 75 years and those >75 years. Clinical follow-up had been done for >600 days, and a prognostic combined event was defined. In men aged 50 to 75 years, we found a statistically significant worse prognosis in patients with short telomeres (log-rank: 5.22, p <0.05) but not in men >75 years (log-rank: 0.01, p = 0.91). Cox analysis confirmed short telomeres in men aged 50 to 75 years as an independent prognostic risk factor. In conclusion, telomere length is a good predictor of cardiovascular prognosis in men admitted for acute coronary syndrome, but this relation depends on the chronological age of the population studied.
authors.affiliation: Department of Cardiology, University Hospital of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. Electronic address: jangel.perezrivera@gmail.com.
authors.forename: Jose-Angel
authors.initials: JA
authors.lastname: Perez-Rivera
authors.affiliation: Department of Cardiology, University Hospital of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Pabon-Osuna
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain; Cancer Research Centre of Salamanca (CIC-IBMCC), Spanish National Research Council (CSIC), Salamanca, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Cieza-Borrella
authors.affiliation: Department of Cardiology, University Hospital of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Duran-Bobin
authors.affiliation: Department of Cardiology, University Hospital of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Martin-Herrero
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Department of Hematology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Jose-Ramon
authors.initials: JR
authors.lastname: Gonzalez-Porras
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain; Cancer Research Centre of Salamanca (CIC-IBMCC), Spanish National Research Council (CSIC), Salamanca, Spain.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Gonzalez-Sarmiento
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012189:Retrospective Studies; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D019098:Telomerase