title: Using advanced noninvasive imaging techniques to probe the links between regional coronary artery endothelial dysfunction and atherosclerosis.
abstract: Cardiovascular disease remains the number one cause of death in the US annually. The development in recent years of imaging strategies that can identify coronary endothelial dysfunction noninvasively provides new information about the early presence and local spatial heterogeneity of endothelial function in patients with, and those at risk for, coronary artery disease. In this article, we will briefly review the mechanisms relating endothelial function and atherosclerosis, contemporary imaging strategies now able to quantify coronary endothelial function noninvasively, and recent insights on human coronary endothelial function.
authors.affiliation: Critical Care Medicine Department, National Institutes of Health, 10 Center Drive, Room 2C145, Bethesda, MD, USA; Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205 USA.
authors.forename: Micaela
authors.initials: M
authors.lastname: Iantorno
authors.affiliation: Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205 USA. Electronic address: rweiss@jhmi.edu.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Weiss
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D061330:Multidetector Computed Tomography; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests