title: H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge.
abstract: The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Florian
authors.initials: F
authors.lastname: Krammer
authors.forename: Irina
authors.initials: I
authors.lastname: Margine
authors.forename: Rong
authors.initials: R
authors.lastname: Hai
authors.forename: Alexander
authors.initials: A
authors.lastname: Flood
authors.forename: Ariana
authors.initials: A
authors.lastname: Hirsh
authors.forename: Vadim
authors.initials: V
authors.lastname: Tsvetnitsky
authors.forename: Dexiang
authors.initials: D
authors.lastname: Chen
authors.forename: Peter
authors.initials: P
authors.lastname: Palese
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D064766:Influenza A Virus, H7N9 Subtype; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D011993:Recombinant Fusion Proteins / Q000235:genetics
chemical_list: D000276:Adjuvants, Immunologic; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D011993:Recombinant Fusion Proteins