title: Genetic score of power-speed and endurance track and field athletes.
abstract: Athletic excelling capability in a specific sport results from the combined influence of hundreds of genetic polymorphisms. The aim of the current study was to characterize athletes' polygenetic scores. We developed two polygenetic scores: (a) Power Genetic Distance Score based on two polymorphisms (PGDS2; ACE(I/D), ACTN3(C/T)) or five polymorphisms (PGDS5; ACTN3(C/T), ACE(I/D), IL6(-174G/C), NOS3(T/C), AGT(MET235THR)); and (b) Endurance Genetic Distance Score based on two polymorphisms (EGDS2; ACEI / D , ACTN3C / T ) or five polymorphisms (EGDS5; PPARGC1(AGly482Ser), PPAR(Aintron7G/C), PPARD(T294C), NRF2(A/C), HIF(C/T)). Eighty-two power-speed athletes, 87 endurance athletes, and 119 nonathletic controls participated in the study. Genomic DNA was extracted from peripheral blood. Power-speed athletes' mean PGDS2 (46.1) and PGDS5 (29.4) were significantly higher compared with their mean EGDS2 (36.4) and EGDS5 (23.1; P < 0.05, P < 0.01, respectively); and compared with controls' mean PGDS2 (36.6) and PGDS5 (24.2; P < 0.05, P < 0.05, respectively). Endurance athletes' mean EGDS2 (60.3) and EGDS5 (35.3) were significantly higher compared with their mean PGDS2 (26.9) and PGDS5 (21.8; P < 0.001, P < 0.001, respectively); and compared with controls' mean EGDS2 (51.2) and EGDS5 (26.1; P < 0.05, P < 0.001, respectively). We conclude that polygenetic scores can differentiate power-speed from endurance athletes. Whether these scores may be used to identify elite power-speed or endurance athletes' needs to be addressed in future studies.
authors.affiliation: Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Ben-Zaken
authors.forename: Y
authors.initials: Y
authors.lastname: Meckel
authors.forename: D
authors.initials: D
authors.lastname: Nemet
authors.forename: A
authors.initials: A
authors.lastname: Eliakim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054874:Athletic Performance / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000235:genetics; D011110:Polymorphism, Genetic; D014142:Track and Field / Q000502:physiology*; D055815:Young Adult
chemical_list: D005819:Genetic Markers
keywords: athletic performance; endurance/power polygenic score; genetic polymorphisms