title: Anaplastic large cell lymphoma mimicking fibrosing mediastinitis.
abstract: Fibrosing mediastinitis is rare. One type of this disease is idiopathic fibrosing mediastinitis. It is necessary to rule out malignancy in order to accurately diagnose fibrosing mediastinitis. We herein report a case of anaplastic large cell lymphoma diagnosed three months after a preliminary diagnosis of fibrosing mediastinitis. Glucocorticoid therapy was not successful in controlling disease progression. Immediately after initiating chemotherapy for lymphoma, the patient's symptoms improved dramatically and the mediastinal lesion decreased in size. Although few similar cases have been reported, hidden malignancy may present as fibrosing mediastinitis. Therefore, physicians should consider the probability of malignancy in patients with fibrosing mediastinitis because treatments may vary accordingly.
authors.affiliation: Department of Respiratory Medicine, Osaka Red Cross Hospital, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Taki
authors.forename: Shinya
authors.initials: S
authors.lastname: Inada
authors.forename: Ryo
authors.initials: R
authors.lastname: Ariyasu
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Konishi
authors.forename: Natsumi
authors.initials: N
authors.lastname: Okamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
authors.forename: Kenji
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Yasukiyo
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Chie
authors.initials: C
authors.lastname: Yoshimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Wakayama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nishizaka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tsudo
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Amitani
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D003951:Diagnostic Errors; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000188:drug therapy; D008480:Mediastinitis / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000008:administration & dosage; D019275:Radiopharmaceuticals; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012598:Sclerosis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D001761:Bleomycin; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; D011241:Prednisone