title: Deep brain stimulation for tremor resulting from acquired brain injury.
abstract: OBJECTIVE
  To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).
  
  
  METHODS
  A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.
  
  
  RESULTS
  VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.
  
  
  CONCLUSIONS
  VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Sitsapesan
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: P
authors.initials: P
authors.lastname: Holland
authors.affiliation: Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Oliphant
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: N
authors.initials: N
authors.lastname: De Pennington
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Oxford University, Institute for Biomedical Engineering, Oxford, Oxfordshire, UK.
authors.forename: J-S
authors.initials: JS
authors.lastname: Brittain
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: N
authors.initials: N
authors.lastname: Jenkinson
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: C
authors.initials: C
authors.lastname: Joint
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Aziz
authors.affiliation: Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000150:complications*; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D016037:Single-Blind Method; D016896:Treatment Outcome; D014202:Tremor / Q000209:etiology / Q000628:therapy*; D055815:Young Adult
keywords: Electrical Stimulation; Head Injury; Movement Disorders; Neurosurgery; Tremor