title: Apolipoprotein A-V level may contribute to the development of obesity-associated dyslipidemia.
abstract: OBJECTIVE
  In a mice study, insulin suppressed apolipoprotein A-V (apoA-V) gene expression in a dose dependent manner. Thus, we investigated the association between apoA-V levels and dyslipidemias in obese children with hyperinsulinemia.
  
  
  METHODS
  The subjects were 17 obese children (15 male, 2 female) aged 11.8 ± 2.4 years. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglyceride (TG), apoA-V and insulin levels were determined.
  
  
  RESULTS
  Obese children with hyperinsulinemia had greater percent overweight, higher TG level, lower HDLC level and lower apoA-V level than those without hyperinsulinemia. In simple regression analysis, apoA-V level correlated negatively with TG (r = -0.613, p = 0.0152) and insulin levels (r = -0.566, p = 0.0279), and positively correlated with HDLC (r = 0.811, p = 0.0002). In stepwise regression analysis, insulin level emerged as the independent determinant of TG level after apoA-V level was taken into account, whereas apoA-V emerged as the independent determinant of HDLC level after adjusting for insulin level.
  
  
  CONCLUSIONS
  Insulin may be a potent regulator of serum apoA-V level in obesity, and apoA-V level may partly contribute to the development of obesity-associated dyslipidemia.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan. Electronic address:okada.tomoo@nihon-u.ac.jp.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Yoshino
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Abe
authors.forename: Minako
authors.initials: M
authors.lastname: Odaka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuromori
authors.forename: Ryuta
authors.initials: R
authors.lastname: Yonezawa
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Iwata
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
mesh_terms: D000293:Adolescent; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood*; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D050177:Overweight / Q000097:blood / Q000150:complications; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides