title: Homogeneity in case/control numbers and north Indian caste criteria in cervical cancer/female urology genetic- studies at a premier medical research institute in lucknow, India.
abstract: Cervical cancer has emerged as a major public health problem in Lucknow and New York in the 21st century. Cancer genetic studies are essential to identify/stratify disease-susceptible individuals in a population-based cohort. Sample size homogeneity and North Indian caste in female urology genetic-studies are significant issues in meaningful interpretation of data. A review of scientific literature using Pubmed database was conducted, including an assessment of cervical cancer genetic studies conducted as part of the author's doctoral dissertation at a premier Lucknow-based medical research Institute. Sample size numbers and caste criteria in the North Indian cohort (N≤400 subjects) were evaluated with homogeneity in the sample cohort data set(s). Subgroup caste-stratification of North Indian cohort is equally essential, for instance, Brahmin (e.g. Pandey), Vaishya (e.g. Mittal), Rajput (e.g. Singh) and Kshudra (e.g. Yadav) during the conception and design of genetics-based studies. Sample size homogeneity in histopathologically confirmed case and control numbers and caste-based stratification in a North Indian cohort is essential in single nucleotide polymorphism (SNP) studies in cervical cancer susceptible populations to draw more definitive conclusions.
authors.affiliation: Krishna Medical Centre, Lucknow, India E-mail : saumyapandey6@yahoo.com.
authors.forename: Saumya
authors.initials: S
authors.lastname: Pandey
authors.lastname: Chandravati
mesh_terms: D000047:Academies and Institutes; D005260:Female; D005828:Genetics, Population; D006801:Humans; D007194:India / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012196:Review Literature as Topic; D014572:Urology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*