title: Panthenol-stabilized cerium dioxide nanoparticles for cosmeceutic formulations against ROS-induced and UV-induced damage.
abstract: A method of panthenol-stabilized cerium dioxide nanoparticles synthesis was developed and their effect on the survival rate of human epidermoid cancer cells HEp-2 and diploid epithelial swine testicular cell line (ST-cells) under oxidative stress conditions induced by hydrogen peroxide introduction and UV irradiation was studied. The results obtained indicate that the use of panthenol as a stabilizer supposedly provides a substantial increase in the efficiency of protection. The degree of protection is determined by panthenol-to-ceria molar ratio. The combination of panthenol and nano-ceria protects biological objects under study from reactive oxygen species (ROS) and UV-irradiation more effectively than individual panthenol or ceria. The protective action of panthenol-stabilized cerium dioxide nanoparticles depends strongly on their composition and the means of their application.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
authors.forename: A B
authors.initials: AB
authors.lastname: Shcherbakov
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
authors.forename: A S
authors.initials: AS
authors.lastname: Bogorad-Kobelska
authors.affiliation: Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences, Moscow 119991, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Ivanova
authors.affiliation: Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences, Moscow 119991, Russia.
authors.forename: A Ye
authors.initials: AY
authors.lastname: Baranchikov
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
authors.forename: N Ya
authors.initials: NY
authors.lastname: Spivak
authors.affiliation: Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences, Moscow 119991, Russia; Department of Materials Science of Lomonosov Moscow State University, Moscow 119991, Russia. Electronic address: van@igic.ras.ru.
authors.forename: V K
authors.initials: VK
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002563:Cerium / Q000737:chemistry* / Q000494:pharmacology; D003358:Cosmetics; D006801:Humans; D006861:Hydrogen Peroxide; D053768:Metal Nanoparticles / Q000737:chemistry*; D016877:Oxidants; D018384:Oxidative Stress / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology; D013552:Swine; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D003358:Cosmetics; D016877:Oxidants; D011837:Radiation-Protective Agents; D010205:Pantothenic Acid; C007288:dexpanthenol; D002563:Cerium; C030583:ceric oxide; D006861:Hydrogen Peroxide
keywords: Cell lines; Cerium dioxide nanoparticles; D-panthenol; Hydrogen peroxide; Reactive oxygen species; UV-irradiation