title: International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I).
abstract: The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Stella K
authors.initials: SK
authors.lastname: Kim
authors.forename: Reza
authors.initials: R
authors.lastname: Dana
authors.forename: Janine
authors.initials: J
authors.lastname: Clayton
authors.forename: Sandeep
authors.initials: S
authors.lastname: Jain
authors.forename: Mark I
authors.initials: MI
authors.lastname: Rosenblatt
authors.forename: Victor L
authors.initials: VL
authors.lastname: Perez
authors.forename: Hasanain
authors.initials: H
authors.lastname: Shikari
authors.forename: Anjo
authors.initials: A
authors.lastname: Riemens
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005123:Eye / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D008297:Male; D055815:Young Adult