title: Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study.
abstract: BACKGROUND
  Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies.
  
  
  METHODS
  Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance.
  
  
  CONCLUSIONS
  This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.
authors.affiliation: Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina NT 0811, Darwin, Australia. louise.maple-brown@menzies.edu.au.
authors.forename: Louise J
authors.initials: LJ
authors.lastname: Maple-Brown
authors.forename: Alex
authors.initials: A
authors.lastname: Brown
authors.forename: I-Lynn
authors.initials: IL
authors.lastname: Lee
authors.forename: Christine
authors.initials: C
authors.lastname: Connors
authors.forename: Jeremy
authors.initials: J
authors.lastname: Oats
authors.forename: Harold D
authors.initials: HD
authors.lastname: McIntyre
authors.forename: Cherie
authors.initials: C
authors.lastname: Whitbread
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Moore
authors.forename: Danielle
authors.initials: D
authors.lastname: Longmore
authors.forename: Glynis
authors.initials: G
authors.lastname: Dent
authors.forename: Sumaria
authors.initials: S
authors.lastname: Corpus
authors.forename: Marie
authors.initials: M
authors.lastname: Kirkwood
authors.forename: Stacey
authors.initials: S
authors.lastname: Svenson
authors.forename: Paula
authors.initials: P
authors.lastname: van Dokkum
authors.forename: Sridhar
authors.initials: S
authors.lastname: Chitturi
authors.forename: Sujatha
authors.initials: S
authors.lastname: Thomas
authors.forename: Sandra
authors.initials: S
authors.lastname: Eades
authors.forename: Monique
authors.initials: M
authors.lastname: Stone
authors.forename: Mark
authors.initials: M
authors.lastname: Harris
authors.forename: Chrissie
authors.initials: C
authors.lastname: Inglis
authors.forename: Karen
authors.initials: K
authors.lastname: Dempsey
authors.forename: Michelle
authors.initials: M
authors.lastname: Dowden
authors.forename: Michael
authors.initials: M
authors.lastname: Lynch
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Boyle
authors.forename: Sue
authors.initials: S
authors.lastname: Sayers
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shaw
authors.forename: Paul
authors.initials: P
authors.lastname: Zimmet
authors.forename: Kerin
authors.initials: K
authors.lastname: O'Dea
mesh_terms: D000886:Anthropometry; D001724:Birth Weight; D001942:Breast Feeding; D002657:Child Development; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015876:Northern Territory / Q000453:epidemiology; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011254:Pregnancy in Diabetics / Q000453:epidemiology*; D012107:Research Design; D012923:Social Class