title: PET radioligands targeting the brain GABAA /benzodiazepine receptor complex.
abstract: The development of positron emission tomography radioligands for the GABAA /benzodiazepine receptor complex (GABAA receptor) labeled with (11) C and (18) F is examined. The review covers labeling strategies as well as brief biological evaluations of radioligands. In addition, we assess the special considerations that must be taken during a development program for radioligands targeting the GABAA receptor and explore some of the challenges that lie ahead.
authors.affiliation: Department of Clinical Neuroscience, Center for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jan D
authors.initials: JD
authors.lastname: Andersson
authors.forename: Christer
authors.initials: C
authors.lastname: Halldin
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D058785:GABA-A Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A
keywords: F-18; GABA; benzodiazepine; radiochemistry; radioligand