title: Evidence for bilateral endolymphatic hydrops in ipsilateral delayed endolymphatic hydrops: preliminary results from examination of five cases.
abstract: CONCLUSIONS
  After the administration of a standard dose of gadodiamide, an intravenous gadolinium-based contrast agent (GBCA), magnetic resonance imaging (MRI) evaluation of endolymphatic hydrops (EH) became possible in patients with ipsilateral delayed endolymphatic hydrops (DEH). We found that patients with ipsilateral DEH may also have bilateral EH.
  
  
  OBJECTIVE
  MRI evaluation contributes to understanding of the pathological conditions in patients with EH. However, double or triple the standard dose of GBCA is often required to obtain images of high quality. We attempted to examine EH bilaterally in patients with ipsilateral DEH after routine administration of an intravenous GBCA.
  
  
  METHODS
  GBCA (gadodiamide, 0.2 ml/kg) was administered intravenously to five patients with ipsilateral DEH. Three-dimensional fluid attenuated inversion recovery (3D-FLAIR) MRI was performed with a 3-T MRI scanner 4 h after GBCA administration.
  
  
  RESULTS
  In all five patients, EH was observed in the affected vestibules. Moreover, EH was observed bilaterally in four (80%) of five patients with ipsilateral DEH. The region of the deaf ear affected by EH was considerably larger compared with the normal ear in three patients. However, observed regions of EH were of approximately the same size in both ears in patients 4 and 5.
authors.affiliation: Department of Otolaryngology, Aichi Medical University , Nagakute, Aichi.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonoyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Tamaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamamuro
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ueda
mesh_terms: D000293:Adolescent; D000328:Adult; D001301:Audiometry, Pure-Tone; D003287:Contrast Media / Q000008:administration & dosage; D018159:Endolymphatic Hydrops / Q000175:diagnosis*; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage; D046088:Hearing Loss, Unilateral / Q000175:diagnosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA