title: Therapeutic perspectives of Eph-ephrin system modulation.
abstract: Eph receptors are the largest class of kinase receptors and, together with their ligands ephrins, they have a primary role in embryogenesis. Their expression has been found deregulated in several cancer tissues and, in many cases, abnormal levels of these proteins have been correlated to a poor prognosis. Recently, the Eph-ephrin system was found to be deregulated in other pathological processes, involving the nervous and cardiovascular systems. The increasing body of evidence supports the Eph-ephrin system as a target not only for the treatment of solid tumors, but also to face other critical diseases such as amyotrophic lateral sclerosis and diabetes driving current efforts toward the development of pharmacological tools potentially able to treat these pathologies.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze 27/A, 43124 Parma, Italy. Electronic address: massimiliano.tognolini@unipr.it.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Tognolini
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
authors.forename: Iftiin
authors.initials: I
authors.lastname: Hassan-Mohamed
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Giorgio
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Zanotti
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Lodola
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism; D001168:Arthritis / Q000188:drug therapy / Q000378:metabolism; D036342:Ephrins / Q000037:antagonists & inhibitors* / Q000502:physiology*; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D036081:Receptors, Eph Family / Q000037:antagonists & inhibitors* / Q000502:physiology*
chemical_list: D036342:Ephrins; D047428:Protein Kinase Inhibitors; D036081:Receptors, Eph Family