title: Aging: filtering out bad mitochondria.
abstract: During yeast cytokinesis an aged mother cell gives rise to an immaculate daughter cell. A new study now demonstrates that this rejuvenation encompasses a novel Sir2- and actin-cable-dependent filtering process that prevents feeble mitochondria from entering the daughter cell.
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, S-413 90 Göteborg, Sweden. Electronic address: Thomas.nystrom@cmb.gu.se.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nyström
mesh_terms: D000199:Actins / Q000235:genetics; D000375:Aging / Q000235:genetics*; D060049:Asymmetric Cell Division; D019070:Cell Lineage; D048749:Cytokinesis; D008928:Mitochondria / Q000473:pathology*; D009218:Myosins / Q000235:genetics; D010084:Oxidation-Reduction; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000096:biosynthesis / Q000235:genetics*; D056565:Sirtuin 2 / Q000096:biosynthesis / Q000235:genetics*; D014335:Tropomyosin / Q000235:genetics
chemical_list: D000199:Actins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D014335:Tropomyosin; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D009218:Myosins