title: Sirtuins and cancer: new insights and cell signaling.
abstract: Sirtuins are involved in the control of the cell cycle and regulation of gene transcription. While some sirtuins have tumor suppressor effects, others regulate tumors metabolism. Within this perspective, the present article is a review of the current role of sirtuins in the etiology and physiopathology of cancer. Sirtuins show strong potential to become a valuable predictive and prognostic marker for cancer and are eligible as therapeutic targets for a variety of tumors. Investigation of new molecules able to modulate sirtuins activity must be encouraged.
authors.affiliation: 1Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, MG, Brazil.
authors.forename: Marcos Vinícius Macedo
authors.initials: MV
authors.lastname: de Oliveira
authors.forename: João Marcus Oliveira
authors.initials: JM
authors.lastname: Andrade
authors.forename: Alanna Fernandes
authors.initials: AF
authors.lastname: Paraíso
authors.forename: Sérgio Henrique Sousa
authors.initials: SH
authors.lastname: Santos
mesh_terms: D014408:Biomarkers, Tumor; D002453:Cell Cycle; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D014408:Biomarkers, Tumor; D037761:Sirtuins