title: High prevalence of subclinical thyroid dysfunction and the relationship between thyrotropin levels and cardiovascular risk factors in residents of the coastal area of China.
abstract: OBJECTIVE
  To investigate the prevalence of subclinical thyroid dysfunction and the relationship between thyrotropin levels and cardiovascular risk factors in residents of the coastal area of China.
  
  
  METHODS
  Atotalof4256individuals(mean[±SD]age50.51±14.24years; 2079 males, 2177 females,) were enrolled in the present study. Sex, blood pressure, body mass index, waist-to-hip ratio, serum levels of fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid and smoking status were measured. The relationship between thyrotropin levels and cardiovascular risk factors was analyzed.
  
  
  RESULTS
  The overall prevalence of thyroid dysfunction was 11.07%. The prevalence of subclinical hypothyroidism (6.32%) was higher than that of hyperthyroidism (1.53%). The prevalence of thyroid dysfunction among female subjects was higher than that among male subjects (16.54% versus 5.34%, respectively; P<0.001). Significant differences were detected with respect to body mass index (P=0.026), waist-to-hip ratio (P<0.001), fasting glucose levels (P=0.001), total cholesterol levels (P=0.013), triglyceride levels (P=0.003) and smoking status according to different thyrotropin levels.
  
  
  CONCLUSIONS
  The prevalence of thyroid dysfunction was high in residents of China's coastal area. Significant differences were detected with regard to body mass index, waist-to-hip ratio, fasting glucose levels, total cholesterol levels, triglyceride levels and smoking status according to different thyrotropin levels.
authors.affiliation: Department of Cardiology, Binzhou Medical College, Yantai, China;
authors.forename: Jinqian
authors.initials: J
authors.lastname: Wang
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Ma
authors.forename: Shuying
authors.initials: S
authors.lastname: Qu
authors.forename: Yingzheng
authors.initials: Y
authors.lastname: Li
authors.forename: Lihui
authors.initials: L
authors.lastname: Han
authors.forename: Xun
authors.initials: X
authors.lastname: Sun
authors.forename: Peimei
authors.initials: P
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Liu
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
keywords: Cardiovascular risk factors; Coronary heart disease; Thyroid dysfunction