title: Clinical features and survival analysis of very young (age<35) breast cancer patients.
abstract: OBJECTIVE
  To compare the clinicalpathological features and prognosis between premenopausal breast cancer patients aged of <35 and ≥35 years old.
  
  
  METHODS
  The clinical data and survival status of 1498 cases premenopausal operable breast cancer treated in our hospital from 2002.1 to 2004. 12 were collected, 118 cases were aged <35. They were divided into 4 groups: Luminal A, Luminal B, HER2-positive, Triple-negative. The disease free survival (DFS) and overall survival (OS) were identified.
  
  
  RESULTS
  The 5-year DFS and OS rates were significantly lower in age<35 than in age≥35 patients. In the Luminal B, HER2-positive, Triple-negative group, the 5-year recurrence risk was higher in age<35 than in age≥35 patients, and age<35 patients' 5-year death risk was higher only in Luminal B, Triple-negative group. Regardless of whether lymph node involved, age<35 patients had a bad prognosis in both DFS and OS.
  
  
  CONCLUSIONS
  Compared with premenopausal age ≥35 breast cancer, age<35 patients had a worse outcome.
authors.affiliation: Department of Ultrasonic Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China E-mail : dr.zhangsheng@yahoo.cn.
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Wei
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Xin
authors.forename: Zhong-Sheng
authors.initials: ZS
authors.lastname: Tong
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D017697:Premenopause; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone