title: Outcome of tonsillectomy for recurrent IgA nephropathy after kidney transplantation.
abstract: Since 2007, we have performed tonsillectomies for patients with recurrent immunoglobulin A nephropathy (IgAN) after kidney transplantation. Seven patients with primary IgAN showed biopsy-proven recurrent IgAN after living-donor kidney transplantation. They had persistent proteinuria or hematuria for an average of 40.3 months, and tonsillectomy was performed, on average, 75.6 months after kidney transplantation. In six patients with observation periods of more than one year, good remission of urinary findings was observed after tonsillectomy. We classified the seven patients into three types of renal injury based on histological findings: severe, moderate, and mild. Two patients classified with severe renal injury at the time of tonsillectomy had other problems, such as refractory hypertension and bilateral sinusitis. They followed a rapidly progressive clinical course. One case already had moderate histological renal injury. He demonstrated prompt amelioration of urinary findings after tonsillectomy but immediate deviation from remission of proteinuria and hematuria. In the four cases presenting mild renal injury at tonsillectomy, the improved urinary findings and serum creatinine value after tonsillectomy have persisted. In conclusion, tonsillectomy may be a favorable treatment for cases of mild-grade IgAN. However, other treatments such as antihypertensive agents and diet therapy may be necessary in other grades.
authors.affiliation: Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Koshino
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Ushigome
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sakai
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Syuji
authors.initials: S
authors.lastname: Nobori
authors.forename: Hideaki
authors.initials: H
authors.lastname: Okajima
authors.forename: Naoko
authors.initials: N
authors.lastname: Masuzawa
authors.forename: Norio
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D006417:Hematuria / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D055502:Secondary Prevention; D014068:Tonsillectomy; D016896:Treatment Outcome
chemical_list: D003404:Creatinine
keywords: IgA nephropathy; kidney transplantation; recurrence; tonsillectomy