title: Biological activity of propolis-honey balm in the treatment of experimentally-evoked burn wounds.
abstract: Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey--products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.
authors.affiliation: Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, Poland. rstojko@sum.edu.pl.
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Jastrzębska-Stojko
authors.forename: Rafał
authors.initials: R
authors.lastname: Stojko
authors.forename: Anna
authors.initials: A
authors.lastname: Rzepecka-Stojko
authors.forename: Agata
authors.initials: A
authors.lastname: Kabała-Dzik
authors.forename: Jerzy
authors.initials: J
authors.lastname: Stojko
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy*; D003094:Collagen / Q000378:metabolism; D006722:Honey; D006909:Hydroxyproline; D011429:Propolis / Q000737:chemistry*; D013552:Swine
chemical_list: D003094:Collagen; D011429:Propolis; D006909:Hydroxyproline