title: [Respirtory distress in newborns of mothers with factor V-Leiden thrombophilia].
abstract: OBJECTIVE
  The main aim of the trial is to determine the frequency of respiratory distress syndrome / RDS/ and disorders of coagulation in infants of mothers with thrombophilia.
  
  
  METHODS
  In 51 newborns of mothers with thrombophilia were evaluated the presence of respiratory distress and maternal-fetal infection /MFI/. The children were divided in two groups: Group I--16 newborns of mothers with thrombophilia and Group II--15 healthy children. We analyzed Hb, Ht, Er, Thr, prothrombin index /INR/, activated partial thromboplastin time /aPTT/ in both groups.
  
  
  RESULTS
  The analysis of Hb, Ht, Er, Thr showed no evidence of anemia or coagulopathy with platelet consumption. In 64.7% of children was observed respiratory distress syndrome during the first days, 21.5% had severe respiratory distress /RD/, that required intubation and assisted ventilation. Only in 10/19.6%/ children with RDS there were data proving MFI/high CRP and positive microbiological samples/. There was no significant difference in the INR value in Group I/1.5 +/- 0.3/ and group II/1.6 +/- 0.1/. The children of mothers with thrombophilia had significantly more shortened aPTT/35, 1s +/- 4.2/ compared with the control group: aPTT/43.9 +/- 4,4/.
  
  
  CONCLUSIONS
  The high incidence of RDS and shortened aPTT indicate that maternal thrombophilia is a risk factor for thrombosis in newborns. MFI that are accompanied with activated PAI also lead to thrombosis, especially in children in Neonatal Intensive Care Units. These results point out that there should be prevention of other risk factors for thrombosis such as dehydration and placement of central venous catheters.
authors.forename: T
authors.initials: T
authors.lastname: Pramatarova
authors.forename: B
authors.initials: B
authors.lastname: Marinov
authors.forename: B
authors.initials: B
authors.lastname: Slancheva
authors.forename: N
authors.initials: N
authors.lastname: Yarakova
authors.forename: A
authors.initials: A
authors.lastname: Popivanova
authors.forename: E
authors.initials: E
authors.lastname: Doycheva
authors.forename: S
authors.initials: S
authors.lastname: Hitrova
authors.forename: P
authors.initials: P
authors.lastname: Radulova
authors.forename: Z
authors.initials: Z
authors.lastname: Emilova
mesh_terms: D001780:Blood Coagulation Tests; D002031:Bulgaria / Q000453:epidemiology; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood* / Q000453:epidemiology* / Q000628:therapy; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood*; D013927:Thrombosis / Q000453:epidemiology
chemical_list: C095381:factor V Leiden; D005165:Factor V