title: CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis.
abstract: OBJECTIVE
  The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD).
  
  
  METHODS
  CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls.
  
  
  RESULTS
  The mean CA 125 level in patients, 38.78 ± 35.48 U/mL, was significantly higher than that found in healthy controls (9.20 ± 4.55 U/mL; p = 0.003). Patients with elevated CA 125 levels (n = 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r = 0.596, p < 0.05) and C-reactive protein (CRP) levels (r = 0.439, p < 0.05), as well as LVEDd (r = 0.599, p < 0.001), LVESd (r = 0.750, p < 0.001) and LV mass index (r = 0.378, p < 0.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r = -0.513, p < 0.05) and hemoglobin (r = -0.475, p < 0.05) as well as the EF (r = -0.878, p < 0.0001). A depressed EF (β = -1.121, p < 0.0001) and increased CRP levels (β = 0.247, p = 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model.
  
  
  CONCLUSIONS
  Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.
authors.affiliation: Department of Internal Medicine, Section of Nephrology, Turgut Ozal University, School of Medicine , Ankara , Turkey .
authors.forename: Hakki
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Ozgül Malcok
authors.initials: OM
authors.lastname: Gürel
authors.forename: Hüseyin Tugrul
authors.initials: HT
authors.lastname: Celik
authors.forename: Enes
authors.initials: E
authors.lastname: Sahiner
authors.forename: Mehmet Erol
authors.initials: ME
authors.lastname: Yildirim
authors.forename: Mukadder Ayşe
authors.initials: MA
authors.lastname: Bilgiç
authors.forename: Nuket
authors.initials: N
authors.lastname: Bavbek
authors.forename: Ali
authors.initials: A
authors.lastname: Akcay
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D018394:CA-125 Antigen / Q000097:blood*; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D006435:Renal Dialysis; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D018394:CA-125 Antigen; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein