title: An intelligent nanotheranostic agent for targeting, redox-responsive ultrasound imaging, and imaging-guided high-intensity focused ultrasound synergistic therapy.
abstract: A novel multifunctional nanotheranostic agent with targeting, redox-responsive ultrasound imaging and ultrasound imaging-guided high-intensity focused ultrasound (HIFU) therapy (MSNC-PEG-HA(SS)-PFH, abbreviated as MPH(SS)-PFH) capabilities is developed. The redox-responsive guest molecule release and ultrasound imaging functions can be both integrated in such a "smart" theranostic agent, which is accomplished by the redox-triggered transition from the crosslinking state to retrocrosslinking state of the grafted polyethylene glycol-disulfide hyaluronic acid molecules on the particle surface when reaching a reducing environment in vitro. More importantly, under the tailored ultrasound imaging guiding, in vivo Hela tumor-bearing nude mice can be thoroughly and spatial-accurately ablated during HIFU therapy, due to the targeted accumulation, responsive ultrasound imaging guidance and the synergistic ablation functions of nanotheranostic agent MPH(SS)-PFH in the tumors. This novel multifunctional nano-platform can serve as a promising candidate for further studies on oncology therapy, due to its high stability, responsive and indicative ultrasound imaging of tumors, and enhanced HIFU therapeutic efficiency and spatial accuracy under ultrasound-guidance.
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Faqi
authors.initials: F
authors.lastname: Li
authors.forename: Deping
authors.initials: D
authors.lastname: Zeng
authors.forename: Shuguang
authors.initials: S
authors.lastname: Zheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Lixin
authors.initials: L
authors.lastname: Jiang
authors.forename: Huixiong
authors.initials: H
authors.lastname: Xu
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000327:Adsorption; D000818:Animals; D003952:Diagnostic Imaging; D006367:HeLa Cells; D056945:Hep G2 Cells; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008819:Mice, Nude; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature
chemical_list: D053769:Nanocapsules; D011108:Polymers; D012822:Silicon Dioxide
keywords: high intensity focused ultrasound; mesoporous silica nanocapsules; nanotheranostic agent; responsive ultrasound imaging