title: Complete nucleotide sequence of a norovirus GII.4 genotype: evidence for the spread of the newly emerged pandemic Sydney 2012 strain to China.
abstract: A newly emerged pandemic Sydney GII.4-like norovirus (NoV) (Jingzhou GII.4) was isolated in Jingzhou, China in April, 2013, demonstrating the rapid spread of the variant to China. The complete nucleotide sequence was compared with the prototype Sydney 2012 variant and its VP1 gene with that of Huzhou strain (isolated in January 2013 in Huzhou, China). The result demonstrates that the new variant has evolved rapidly, including mutations in the hypervariable P2 domain of the major capsid protein VP1. Our study also shows that the new Jingzhou GII.4 variant co-circulated with GII.3 and GI.2 at the same time, supporting further monitoring of the evolution of the new NoV variant in China.
authors.affiliation: Wuhan Institute of Biological Products Co., Ltd., 9 Linjiang Avenue, Wuchang, Wuhan, 430060, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Huo
authors.forename: Ailing
authors.initials: A
authors.lastname: Cai
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Mingli
authors.initials: M
authors.lastname: Zhou
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Yan
authors.forename: Dingxiang
authors.initials: D
authors.lastname: Liu
authors.forename: Shuo
authors.initials: S
authors.lastname: Shen
mesh_terms: D002681:China; D005814:Genes, Viral; D005838:Genotype; D029322:Norovirus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny