title: Polyphenols: a nutraceutical approach against diseases.
abstract: Polyphenols are abundant in red grapes and in their derived products, amongst other natural food sources. These compounds are associated with the prevention of diseases caused by oxidative stress. The present review discusses the action of grape polyphenols against diseases and the new polyphenol-rich products developed to be used as nutraceuticals. Grape polyphenols demonstrated effects such as maintenance of endothelial function, increase in antioxidant capacity and protection against LDL oxidation. Recent patents regarding polyphenols show a tendency to use a right-on-target approach and the new patented products are aiming at preventing and treating specific diseases.
authors.forename: Andréa P B
authors.initials: AP
authors.lastname: Gollucke
authors.forename: Rogério C
authors.initials: RC
authors.lastname: Peres
authors.lastname: Odair A
authors.affiliation: HEXALAB/UNISANTOS - Catholic University of Santos. Av. Conselheiro Nebias, 300. Santos-SP 11015-002. Brazil. gollucke@uol.com.br.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Ribeiro
mesh_terms: D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010330:Patents as Topic; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D059808:Polyphenols