title: Volatile oil from striped African pepper (Xylopia parviflora, Annonaceae) possesses notable chemopreventive, anti-inflammatory and antimicrobial potential.
abstract: Fruits of Xylopia parviflora, well known as striped African pepper, are sold in the Cameroonian markets as a flavouring ingredient to make traditional soups. The essential oil hydrodistilled from fruits was analysed for in vitro biological activities, namely cytotoxic, anti-inflammatory, antimicrobial and antioxidant, by MTT, nitric oxide inhibitory assay, agar disc diffusion method, and DPPH and ABTS assays. The essential oil composition, analysed by GC and GC-MS, was dominated by monoterpene hydrocarbons (50.0%) responsible for the pepper odour, such as β-pinene (34.0%) and α-pinene (10.3%). The oil induced a strong inhibitory effect on tumour cells MDA-MB 231 and HCT116, with inhibition values close to those of cisplatin. A dose-dependent decrease in NO production was noted in RAW 264.7 macrophages treated with the oil, revealing a promising anti-inflammatory potential. The essential oil showed a measurable antimicrobial activity against all the species tested, while the radical scavenging activity was low.
authors.affiliation: Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, P.O. Box 183, Dschang, Cameroon; Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Verlaine
authors.initials: V
authors.lastname: Woguem
authors.forename: Hervet P D
authors.initials: HP
authors.lastname: Fogang
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
authors.forename: Léon A
authors.initials: LA
authors.lastname: Tapondjou
authors.forename: Hilaire M
authors.initials: HM
authors.lastname: Womeni
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vitali
authors.forename: Dezemona
authors.initials: D
authors.lastname: Petrelli
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.forename: Sauro
authors.initials: S
authors.lastname: Vittori
authors.forename: Luciano
authors.initials: L
authors.lastname: Barboni
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D054336:Xylopia / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D009822:Oils, Volatile; D020011:Protective Agents
keywords: Anti-inflammatory; Antimicrobial; Cytotoxic activity; Essential oil; Xylopia parviflora