title: Injectable 3-D fabrication of medical electronics at the target biological tissues.
abstract: Conventional transplantable biomedical devices generally request sophisticated surgery which however often causes big trauma and serious pain to the patients. Here, we show an alternative way of directly making three-dimensional (3-D) medical electronics inside the biological body through sequential injections of biocompatible packaging material and liquid metal ink. As the most typical electronics, a variety of medical electrodes with different embedded structures were demonstrated to be easily formed at the target tissues. Conceptual in vitro experiments provide strong evidences for the excellent performances of the injectable electrodes. Further in vivo animal experiments disclosed that the formed electrode could serve as both highly efficient ECG (Electrocardiograph) electrode and stimulator electrode. These findings clarified the unique features and practicability of the liquid metal based injectable 3-D fabrication of medical electronics. The present strategy opens the way for directly manufacturing electrophysiological sensors or therapeutic devices in situ via a truly minimally invasive approach.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jin
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaokang
authors.initials: X
authors.lastname: Li
authors.forename: Xueyao
authors.initials: X
authors.lastname: Yang
authors.forename: Jingjing
authors.initials: J
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D004582:Electronics, Medical / Q000295:instrumentation*; D006801:Humans; D007267:Injections; D051379:Mice; D023421:Models, Animal; D019736:Prostheses and Implants; D013552:Swine