title: CLL/SLL diagnosed in an adolescent.
abstract: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a disease of older adults. Pediatric CLL/SLL is vanishingly rare in the literature. We present a case of CLL/SLL diagnosed in a 17-year-old male. The pathologic findings of this case were those of classic CLL/SLL with an ATM deletion, a characteristic genetic abnormality in CLL/SLL. Management guidelines for CLL/SLL are tailored to older adults making determination of the optimal therapy for this patient a unique challenge.
authors.affiliation: Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Marlise
authors.initials: M
authors.lastname: Luskin
authors.forename: Gerald
authors.initials: G
authors.lastname: Wertheim
authors.forename: Jennifer
authors.initials: J
authors.lastname: Morrissette
authors.forename: Robert
authors.initials: R
authors.lastname: Daber
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Biegel
authors.forename: Donna
authors.initials: D
authors.lastname: Wilmoth
authors.forename: Leslie
authors.initials: L
authors.lastname: Kersun
authors.forename: Rebecca
authors.initials: R
authors.lastname: King
authors.forename: Michele
authors.initials: M
authors.lastname: Paessler
authors.forename: Cara
authors.initials: C
authors.lastname: Simon
authors.forename: Richard
authors.initials: R
authors.lastname: Aplenc
authors.forename: Alison
authors.initials: A
authors.lastname: Loren
mesh_terms: D000293:Adolescent; D000367:Age Factors; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics; D014408:Biomarkers, Tumor; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics / Q000648:ultrastructure; D003952:Diagnostic Imaging; D018628:Gene Dosage; D016259:Genes, myc; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D017384:Sequence Deletion
chemical_list: D014408:Biomarkers, Tumor; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins
keywords: cancer genetics; non-Hodgkin lymphoma; rare tumors