title: Chronic pancreatitis and primary sclerosing cholangitis--first report of intrahepatic autologous islet transplantation.
abstract: BACKGROUND
  We are reporting first successful intrahepatic autologous islet transplantation after total pancreatectomy in a patient with chronic pancreatitis and primary sclerosing cholangitis.
  
  
  METHODS
  Total pancreatectomy and subsequent islet autotransplantation were performed in a 16-year-old boy with intractable pain due to chronic pancreatitis in the setting of ulcerative colitis and primary sclerosing cholangitis (PSC). Liver biopsy revealed PSC with focal bridging fibrosis. The pancreas was surgically removed and digested, and islets were isolated, highly purified, and infused intraportally.
  
  
  RESULTS
  Over 18-month follow-up, the patient did not show progression of chronic liver disease or signs of portal hypertension. Magnetic resonance cholangiopancreatography revealed no new changes, and liver biopsy did not show progression of the periportal fibrosis. Pain medication was weaned over 12 months at which time glycemic control was excellent without exogenous insulin supplementation. HbgA1c was 5.9. Fifteen months after the procedure, stimulation with a mixed meal led to a fourfold increase of serum C-peptide and an eightfold increase of insulin level.
  
  
  CONCLUSIONS
  Pancreatic autologous islets can be successfully transplanted into a liver affected by PSC without compromising hepatic or graft function. Durability of the procedure may be limited in the future by the natural course of the liver injury caused by PSC.
authors.affiliation: Department of Surgery, University of Chicago, Chicago, IL, USA.
authors.forename: Ling-jia
authors.initials: LJ
authors.lastname: Wang
authors.forename: Sona
authors.initials: S
authors.lastname: Young
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Misawa
authors.forename: Ruba
authors.initials: R
authors.lastname: Azzam
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wang
authors.forename: Karolina
authors.initials: K
authors.lastname: Gołąb
authors.forename: Olivia
authors.initials: O
authors.lastname: Cochet
authors.forename: Omid
authors.initials: O
authors.lastname: Savari
authors.forename: Martin
authors.initials: M
authors.lastname: Tibudan
authors.forename: J Michael
authors.initials: JM
authors.lastname: Millis
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Matthews
authors.forename: Piotr
authors.initials: P
authors.lastname: Witkowski
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000378:metabolism; D015209:Cholangitis, Sclerosing / Q000097:blood / Q000150:complications / Q000601:surgery*; D003093:Colitis, Ulcerative / Q000150:complications; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation; D008297:Male; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000097:blood / Q000150:complications / Q000601:surgery*; D014184:Transplantation, Homologous
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D007328:Insulin