title: Maternal and foetal cardiovascular effects of the anaesthetic alfaxalone in 2-hydroxypropyl-β-cyclodextrin in the pregnant ewe.
abstract: The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2-hydroxypropyl- β -cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose. Six pregnant Ripollesa sheep, weighing 47.1 ± 4.4 kg, were used. Twenty-four hours after instrumentation, sheep were anaesthetized with intravenous alfaxalone in cyclodextrin. Time to standing from anaesthesia was 30.0 ± 10.81 min. Foetal heart rate increased significantly during the first 5 min after alfaxalone administration. Significant differences were observed in maternal diastolic arterial blood pressure between minute 10 and minutes 90, 120, 150, 180, 210, and 240. Significant differences were observed for foetal systolic arterial blood pressure between 5 and 30 min after alfaxalone administration. Significant differences in foetal pH were detected during the entire study period, whereas maternal pH returned to baseline values by 60 min after alfaxalone administration. The present study indicated that alfaxalone in 2-hydroxypropyl- β -cyclodextrin administered as an intravenous bolus at 2 mg/kg body weight produced minimal adverse effects and an uneventful recovery from anaesthesia in pregnant sheep and their foetus.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universitat Autonoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Andaluz
authors.forename: Laura
authors.initials: L
authors.lastname: Santos
authors.forename: Félix
authors.initials: F
authors.lastname: García
authors.forename: Rosa I
authors.initials: RI
authors.lastname: Ferrer
authors.forename: Laura
authors.initials: L
authors.lastname: Fresno
authors.forename: Xavier
authors.initials: X
authors.lastname: Moll
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000136:Acid-Base Equilibrium / Q000187:drug effects; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D007275:Injections, Intravenous; D011247:Pregnancy; D011277:Pregnanediones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D034561:Sheep, Domestic; D047392:beta-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D018686:Anesthetics, Intravenous; D011277:Pregnanediones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C006477:alphaxalone