title: Substance P in heart failure: the good and the bad.
abstract: The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending on disease etiology and/or timing. Thus far, these studies indicate that substance P may be protective acutely following ischemia-reperfusion, but damaging long-term in non-ischemic induced remodeling and heart failure. Sensory nerves may be at the apex of the cascade of events leading to heart failure, therefore, they make a promising potential therapeutic target that warrants increased investigation.
authors.affiliation: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, United States; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Dehlin
authors.affiliation: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, United States; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, United States. Electronic address: slevick@mcw.edu.
authors.forename: Scott P
authors.initials: SP
authors.lastname: Levick
mesh_terms: D000818:Animals; D006321:Heart / Q000294:innervation / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D011984:Sensory Receptor Cells / Q000502:physiology; D013373:Substance P / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D013373:Substance P
keywords: Heart failure; Myocardial remodeling; Neuropeptide; Sensory nerve; Substance P; Tachykinin