title: [Composite lymphoma cosisting of mantle cell lymphoma and follicular lymphoma].
abstract: Herein, we report the case of a 56-year-old man with composite lymphoma (CL) comprised of mantle cell lymphoma (MCL) and follicular lymphoma (FL). Six months after developing a right brachial tumor, he was diagnosed as having grade 3 FL with normal-size mantle zone. Simultaneously, advanced stage MCL with a diffuse growth pattern in a sigmoid colon tumor and abnormal lymphoid cells in bone marrow were observed. Thereafter, the right brachial tumor was re-examined and its mantle zone cells were immunophenotypically positive for cyclin D1 (CCND1) and cytogenetically positive for the IgH-CCND1 fusion gene. Consequently, he was diagnosed with composite lymphoma (CL) comprised of FL and MCL. As MCL and FL may form CL, the possible complication of MCL should be considered and steps taken to detect MCL.
authors.affiliation: Department of Internal Medicine, Sakaide City Hospital.
authors.forename: Akihito
authors.initials: A
authors.lastname: Matsuoka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tsushima
authors.forename: Masaki
authors.initials: M
authors.lastname: Tanibuchi
authors.forename: Naomi
authors.initials: N
authors.lastname: Katsuki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Taoka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D058617:Composite Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D019938:Cyclin D1 / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D019938:Cyclin D1