title: In vivo label-free microangiography by laser speckle imaging with intensity fluctuation modulation.
abstract: We present the theory of laser speckle imaging improved with intensity fluctuation modulation, where the dynamic speckle pattern can be isolated from its stationary counterpart. A series of in vivo experiments demonstrate the effectiveness of our method in achieving microangiography and monitoring vascular self-recovering process. All results show the convincing performance of our imaging method in both structural and functional imaging of blood flow, which may have potential applications in biological research and disease diagnosis.
authors.affiliation: Beijing Normal University, Department of Physics and Applied Optics, Beijing Area Major Laboratory, Beijing 100875, China.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Wang
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xianjun
authors.initials: X
authors.lastname: Liang
authors.forename: Guanping
authors.initials: G
authors.lastname: Feng
authors.forename: Xuanlong
authors.initials: X
authors.lastname: Lu
authors.forename: Junbo
authors.initials: J
authors.lastname: Chen
authors.forename: Dingan
authors.initials: D
authors.lastname: Han
authors.forename: Guojian
authors.initials: G
authors.lastname: Yang
mesh_terms: D000792:Angiography / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D054644:Ear Auricle / Q000098:blood supply; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D011817:Rabbits