title: Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study.
abstract: BACKGROUND
  Interleukin-13 (IL-13) has been implicated to be responsible for recruitment of inflammatory cells from the blood to the lung, regulation of matrix metalloproteinase and induction of mucin production and secretion in chronic obstructive pulmonary disease (COPD). We determined plasma IL-13 levels in patients with COPD and investigated its association with common polymorphisms of IL-13 gene in a case-control study.
  
  
  METHODS
  We genotyped 160 cases and 175 control subjects in a local hospital using Mass-Array(TM) Technology Platform then tested the association of four SNPs in IL-13 (rs1295685, rs1800925, rs1881457, rs20541) with COPD, and then determined plasma IL-13 levels in patients with COPD and controls.
  
  
  RESULTS
  Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD. By linkage disequilibrium (LD) analysis, two blocks (rs1881457 and rs1800925; rs20541 and rs1295685) were found. The risk of COPD was found associated with the IL-13 gene polymorphism among southern Chinese Han population. Plasma IL-13 level was increased in COPD patients compared with controls.
  
  
  CONCLUSIONS
  The polymorphism of the IL-13 gene is associated with an increased risk of COPD in southern Chinese Han population. Plasma IL-13 levels were found elevated in patients with COPD.
authors.affiliation: Department of Respiratory Disease, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gong
authors.forename: Guo-chao
authors.initials: GC
authors.lastname: Shi
authors.forename: Huan-ying
authors.initials: HY
authors.lastname: Wan
authors.forename: Kun
authors.initials: K
authors.lastname: Yang
authors.forename: Chun-ming
authors.initials: CM
authors.lastname: Pan
authors.forename: Qi-jian
authors.initials: QJ
authors.lastname: Cheng
authors.forename: Ran-ran
authors.initials: RR
authors.lastname: Dai
authors.forename: Qing-yun
authors.initials: QY
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
chemical_list: D018793:Interleukin-13