title: 2,2,2-Trifluoroacetophenone as an organocatalyst for the oxidation of tertiary amines and azines to N-oxides.
abstract: A cheap, mild and environmentally friendly oxidation of tertiary amines and azines to the corresponding N-oxides is reported by using polyfluoroalkyl ketones as efficient organocatalysts. 2,2,2-Trifluoroacetophenone was identified as the optimum catalyst for the oxidation of aliphatic tertiary amines and azines. This oxidation is chemoselective and proceeds in high-to-quantitative yields utilizing 10 mol % of the catalyst and H2 O2 as the oxidant.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens (Greece), Fax: (+30) 2107274761.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Limnios
authors.forename: Christoforos G
authors.initials: CG
authors.lastname: Kokotos
keywords: N-oxides; green chemistry; hydrogen peroxide; organocatalysis; oxidation