title: Lipid peroxidation and antioxidant status in vagina microenvironment of patients with several common vaginitis.
abstract: OBJECTIVE
  Oxidative stress has been suggested to play an important role in many diseases, including vaginitis. To evaluate oxidative biomarkers in the secretion of cervix samples of vaginitis, this study will illustrate the status of lipid peroxidation and antioxidant status in vaginal microenvironment.
  
  
  METHODS
  A total of 257 patients with vaginitis, including candida vaginitis, bacterial vaginosis, and trichomonas vaginitis were involved in this study. Cervico-vaginal fluid was collected from these patients before and after treatment, and the malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), hydrogen peroxide (H2O2), and vitamin C levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The results revealed that the MDA and H2O2 levels were increased in the vaginitis patients, while there was no significant difference in MDA level among different kinds of vaginitis before treatment. The CAT and vitamin C levels in vaginitis were decreased before treatment. Moreover, the data also showed that the MDA and H2O2 levels were decreased, while the CAT, SOD, and vitamin C levels were increased after received treatment, respectively, and there was no significant difference between controls and vaginitis.
  
  
  CONCLUSIONS
  This study indicated that oxidative stress played an important role in vaginitis.
authors.affiliation: Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Guo
authors.forename: X M
authors.initials: XM
authors.lastname: Hu
authors.forename: D D
authors.initials: DD
authors.lastname: Han
authors.forename: Z P
authors.initials: ZP
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Meng
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D002374:Catalase / Q000378:metabolism; D060833:Cellular Microenvironment; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000378:metabolism; D014621:Vagina / Q000378:metabolism*; D014627:Vaginitis / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase