title: Late-replicating CNVs as a source of new genes.
abstract: Asynchronous replication of the genome has been associated with different rates of point mutation and copy number variation (CNV) in human populations. Here, our aim was to investigate whether the bias in the generation of CNV that is associated with DNA replication timing might have conditioned the birth of new protein-coding genes during evolution. We show that genes that were duplicated during primate evolution are more commonly found among the human genes located in late-replicating CNV regions. We traced the relationship between replication timing and the evolutionary age of duplicated genes. Strikingly, we found that there is a significant enrichment of evolutionary younger duplicates in late-replicating regions of the human and mouse genome. Indeed, the presence of duplicates in late-replicating regions gradually decreases as the evolutionary time since duplication extends. Our results suggest that the accumulation of recent duplications in late-replicating CNV regions is an active process influencing genome evolution.
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Center (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Juan
authors.forename: Daniel
authors.initials: D
authors.lastname: Rico
authors.forename: Tomas
authors.initials: T
authors.lastname: Marques-Bonet
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández-Capetillo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valencia
keywords: CNV; DNA replication timing; Duplicated genes; Evolution