title: Regenerative medicine for epilepsy: from basic research to clinical application.
abstract: Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.
authors.affiliation: Department of Neurological Surgery, Okayama University Graduate School of Medicine, 2-5-1, Shikata-cho, Okayama 700-8558, Japan. tyasu37@cc.okayama-u.ac.jp.
authors.forename: Takao
authors.initials: T
authors.lastname: Yasuhara
authors.forename: Takashi
authors.initials: T
authors.lastname: Agari
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kameda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kondo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuramoto
authors.forename: Meng
authors.initials: M
authors.lastname: Jing
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sasaki
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Toyoshima
authors.forename: Susumu
authors.initials: S
authors.lastname: Sasada
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Sato
authors.forename: Aiko
authors.initials: A
authors.lastname: Shinko
authors.forename: Takaaki
authors.initials: T
authors.lastname: Wakamori
authors.forename: Yu
authors.initials: Y
authors.lastname: Okuma
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Miyoshi
authors.forename: Naoki
authors.initials: N
authors.lastname: Tajiri
authors.forename: Cesario V
authors.initials: CV
authors.lastname: Borlongan
authors.forename: Isao
authors.initials: I
authors.lastname: Date
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D064987:Cell- and Tissue-Based Therapy; D004558:Electric Stimulation; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000637:transplantation; D018696:Neuroprotective Agents / Q000627:therapeutic use; D044968:Regenerative Medicine
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D018696:Neuroprotective Agents