title: Clinical significance of insulin-growth factor 1 and insulin-growth factor 1 receptor expression in gastrointestinal stromal tumors.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract and are mostly driven by KIT and PDGFRA-activation mutations. However, other signaling pathways are involved in pathogenesis and proliferation of GISTs. This study investigates the prognostic significance of insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) and the role of succinate dehydrogenase subunit B (SDHB) in GISTs.
  
  
  METHODS
  Immunohistochemistry (IHC) for IGF1, IGF1R and SDHB was performed in total of 165 GISTs.
  
  
  RESULTS
  The overexpression of IGF1 was evident in tumors with high mitotic count, large tumor size and was correlated with high risk of malignant behavior. IGF1R overexpression was correlated with IGF overexpression, high mitotic count and high risk of malignant behavior. Loss of expression for SDHB was found in only 2 gastric GISTs.
  
  
  CONCLUSIONS
  The overexpression of IGF1 and IGF1R can be useful marker to predict relapse and aggressive behavior in GISTs and has prognostic implications.
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Gu
authors.forename: Young-Kyung
authors.initials: YK
authors.lastname: Bae
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000032:analysis*; D013385:Succinate Dehydrogenase / Q000502:physiology
chemical_list: D007334:Insulin-Like Growth Factor I; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase; D017526:Receptor, IGF Type 1