title: Double carbometallation of alkynes: an efficient strategy for the construction of polycycles.
abstract: Cyclization reactions of alkynes, especially the double carbometallation of alkynes, have drawn much interest from organic chemists because of their high efficiency in the construction of polycycles. Utilizing different nucleophiles or catalytic systems, various efficient strategies to access challenging skeletons have been extensively explored in recent years. In this review, achievements in this field are presented in three major parts (the syn-syn, anti-anti, and syn-anti addition reactions of diynes or two alkyne molecules). Cyclization reactions of diynes initiated by nucleophiles, [2+2+n] cycloaddition, or other processes and reactions, involving two identical or different alkynes are described, which provide facile and reliable approaches to various π systems, medium-sized rings, and even macrocycles.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. jie_wu@fudan.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Pan
authors.forename: Xingxin
authors.initials: X
authors.lastname: Yu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D003500:Cyclization; D061565:Cycloaddition Reaction; D005663:Furans / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D005663:Furans; D008670:Metals; D009570:Nitriles; C039281:furan