title: Copper-Catalyzed Carboxylation of Aryl Iodides with Carbon Dioxide.
abstract: A method for carboxylation of aryl iodides with carbon dioxide has been developed. The reaction employs low loadings of copper iodide/TMEDA or DMEDA catalyst, 1 atm of CO2, DMSO or DMA solvent, and proceeds at 25-70 °C. Good functional group tolerance is observed, with ester, bromide, chloride, fluoride, ether, hydroxy, amino, and ketone functionalities tolerated. Additionally, hindered aryl iodides such as iodomesitylene can also be carboxylated.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA.
authors.forename: Hung
authors.initials: H
authors.lastname: Tran-Vu
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
keywords: Carbon dioxide; arenecarboxylic acids; aryl halides; carboxylation; copper catalysis