title: [Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy].
abstract: High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve the efficient cell-killing effect of boron neutron capture therapy (BNCT) that relies on the nuclear reaction of two essentially nontoxic species, boron-10 ((10)B) and thermal neutrons in boron-loaded tissues. Recent development of boron cluster lipids and their liposomal boron delivery system (BDS) are summarized in this article. Boron compounds that have no affinity to tumor can potentially be delivered to tumor tissues by liposomes, therefore, liposomal BDS would be one of the most attractive approaches for efficient BNCT of various cancers. There are two approaches for BDS: encapsulation of boron compounds into liposomes and incorporation of boron-conjugated lipids into the liposomal bilayer. The combination of both approaches has a potential for reduction of the total dose of liposomes without reducing the efficacy of BNCT.
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D001895:Boron / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D009369:Neoplasms / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D001895:Boron