title: CuI-catalyzed cycloisomerization of propargyl amides.
abstract: The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidized to the ketone under the reaction conditions.
authors.affiliation: Department of Chemical & Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK. w.j.moran@hud.ac.uk.
authors.forename: Ali
authors.initials: A
authors.lastname: Alhalib
authors.forename: Wesley J
authors.initials: WJ
authors.lastname: Moran
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007454:Iodides / Q000737:chemistry*; D007536:Isomerism
chemical_list: D000577:Amides; D007454:Iodides; D003300:Copper; C073870:cuprous iodide; D000433:1-Propanol