title: Single intravenous injection of coenzyme Q10 protects the myocardium after irreversible ischemia.
abstract: Experiments were performed on the model of irreversible myocardial ischemia in Wistar rats. Coenzyme Q10 was injected intravenously 10 min after coronary artery occlusion. On day 21 after myocardial infarction the content of coenzyme Q10 in the left ventricle, liver, and plasma from animals of the treatment group was higher than that in untreated rats by 23, 1042, and 87%, respectively (p<0.05). The area of the necrotic zone was lower, and postinfarction hypertrophy of the left ventricle was less pronounced in coenzyme-receiving rats. Right ventricular hypertrophy did not develop in these animals. These rats were characterized by greater stroke volume (by 24.6%, p<0.05), stroke work (by 34.9%), cardiac output (by 37.8%, p<0.05), ejection fraction (by 35.7%, p<0.05), and contractility (by 22.5%, p<0.05), but lower end-diastolic pressure (by 25.8%, p<0.05) than untreated animals. These data indicate that the development of parenteral ubiquinone preparations holds much promise for urgent therapy of acute cardiovascular disorders.
authors.affiliation: Department of Pharmacology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Russia. Address for correspondence: alexand.ivanov@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: E A
authors.initials: EA
authors.lastname: Gorodetskaya
authors.forename: E I
authors.initials: EI
authors.lastname: Kalenikova
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013318:Stroke Volume / Q000187:drug effects; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D002316:Cardiotonic Agents; D014451:Ubiquinone; C024989:coenzyme Q10