title: A retrospective analysis of the risk factors for allergic reactions induced by the administration of oxaliplatin.
abstract: This study retrospectively investigated the clinical features and risk factors of allergic reactions induced by oxaliplatin administration. This study investigated the incidence of allergic reactions and analysed the background and laboratory data in patients with colorectal cancer treated with oxaliplatin-based chemotherapy at Kyushu Medical Center between April 2012 and September 2012. A total of 62 patients were included in this study. The number of patients in the allergic and non-allergic groups was 7 and 55 respectively. The incidence of allergic reactions was 11.3%. We compared the patients' characteristics and laboratory data between the two groups and found that the average dose of dexamethasone in the allergic group was significantly lower than that observed in the non-allergic group (P = 0.0111). Furthermore, the incidence of allergic reactions in the group that received prophylaxis of less than 12 mg of dexamethasone was significantly higher than that observed in the group that received more than 12 mg of dexamethasone (P = 0.0103). In conclusion, a lower dexamethasone dose is a possible risk factor for allergic reactions induced by the administration of oxaliplatin; however, given the retrospective design used in this study, further validation of this finding is warranted.
authors.affiliation: Department of Pharmacy and Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Takayoshi
authors.forename: K
authors.initials: K
authors.lastname: Sagara
authors.forename: M
authors.initials: M
authors.lastname: Uoi
authors.forename: C
authors.initials: C
authors.lastname: Kawanabe
authors.forename: M
authors.initials: M
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Uchino
authors.forename: N
authors.initials: N
authors.lastname: Misumi
authors.forename: T
authors.initials: T
authors.lastname: Nishino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003907:Dexamethasone
keywords: allergic reaction; dexamethasone; oxaliplatin; risk factor