title: Diagnosis and whole body screening using blood pool scintigraphy for evaluating congenital vascular malformations.
abstract: BACKGROUND
  Because magnetic resonance imaging and angiography are inappropriate for whole-body screening because of high cost or invasiveness, we investigated the potential of whole-body blood pool scintigraphy (WBBPS) as a screening and diagnostic tool for congenital vascular malformations (CVMs).
  
  
  METHODS
  The subjects of the study were 137 patients (mean age: 20 ± 16 years; range: 0.3-68 years) with suspected CVM. Whole-body anterior and posterior images were acquired twenty minutes after injection of 760 MBq (99m)Tc-labeled red blood cells (pediatric dose: 13 MBq/kg). The final diagnosis was determined by clinical findings, magnetic resonance imaging, angiography, Doppler sonography, and lymphoscintigraphy.
  
  
  RESULTS
  Of these patients, 124 had venous malformations, and 13 had lymphatic malformations. WBBPS successfully detected abnormal blood pooling lesions in 96.8% (120/124) of the patients with venous malformations. None of the patients with lymphatic malformation showed abnormal uptake on WBBPS. In addition, WBBPS detected 41 additional abnormal vascular lesions that were not found during initial clinical evaluation in 16.9% (21/124) of the patients with venous malformations.
  
  
  CONCLUSIONS
  WBBPS is a valuable diagnostic and screening modality for the initial evaluation of CVM because of its high characterizing accuracy of 97.1% and the ability to image the whole body.
authors.affiliation: Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri-si, Gyeonggi-do, Korea; Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address: jynm.choi@samsung.com.
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Dong-Ik
authors.initials: DI
authors.lastname: Kim
authors.affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Do
authors.affiliation: Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.affiliation: Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Byung-Tae
authors.initials: BT
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases / Q000151:congenital / Q000000981:diagnostic imaging*; D061305:Lymphoscintigraphy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011868:Radioisotopes; D013667:Technetium; D018608:Ultrasonography, Doppler; D054079:Vascular Malformations / Q000000981:diagnostic imaging*; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D011868:Radioisotopes; D013667:Technetium