title: Acquired von Willebrand syndrome associated with Hashimoto's thyroiditis and subcutaneous mucosa-associated lymphoid tissue lymphoma.
abstract: Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease. We herein report a case of AVWS associated with Hashimoto's thyroiditis and subcutaneous mucosa-associated lymphoid tissue lymphoma. An IgG autoantibody against von Willebrand factor (VWF) was detected. The antibody bound to VWF but did not inhibit VWF activity. Rapid clearance of VWF seemed to be the cause of AVWS in the present case. VWF-containing concentrates stopped the bleeding. Even if such a complication is rare, for AVWS patients, prompt recognition of the underlying mechanism can save lives.
authors.affiliation: Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazumi
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Midori
authors.initials: M
authors.lastname: Shima
mesh_terms: D001323:Autoantibodies / Q000097:blood; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications*; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D014841:von Willebrand Factor / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D014841:von Willebrand Factor