title: Lipid levels are regionally associated with cerebral microbleeds in patients with intracerebral hemorrhage.
abstract: BACKGROUND
  Lipid levels may be involved in intracerebral hemorrhage (ICH) etiology, which suggested that lipid levels may be associated with the etiology of microbleeds (MBs) in patients with ICH. To explore this, we examined the association between lipid levels and MBs in different cerebral regions in patients with ICH.
  
  
  METHODS
  Patients admitted to our hospital with ICH were consecutively and prospectively included. Demographic and clinical information were collected and analyzed according to the occurrence and location of MBs and levels of triglycerides (TGs).
  
  
  RESULTS
  Of the 77 patients included in our study, 63 (81.8%) were found to have MBs. Prevalence of MBs in the "deep or infratentorial" region and any region increased with increasing tercile in TG concentration; however, no such trend was observed for strictly lobar MBs. The odds ratio (OR) for occurrence of MBs in deep or infratentorial region was even higher for the third tercile relative to the first: 6.77 (95% confidence interval [CI] 1.31-34.96). The OR for occurrence of MB in any region was even higher for the third tercile relative to the first: 12.24 (95% CI 1.40-106.83). However, the OR for occurrence of deep or infratentorial region and any region in the second tercile relative to the first tercile did not reach significance. Moreover, TG levels did not appear to be associated with the occurrence of strictly lobar MBs.
  
  
  CONCLUSIONS
  High TGs were associated with deep or infratentorial and any MBs but not with lobar MBs. This finding may shed light on the role of lipids in MB and ICH etiology.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China.
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China. Electronic address: dragonwbtxf@hotmail.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan Province, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: You
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D014280:Triglycerides
keywords: Lipid levels; intracerebral hemorrhage; microbleeds; triglyceride