title: Endogenous compounds labeled with radionuclides of short half-life-some perspectives.
abstract: In the article, the strategy and synthesis of some endogenous compounds labeled mainly with (11) C are presented. There are some examples illustrating how endogenous labeled compounds in connection with positron emission tomography have unique properties to describe various biological processes, and a few examples of the use of tracers labeled with (13) N and (15) O are also discussed. Labeled endogenous compounds may be an important asset to describe the conditions and the status of biological systems and might therefore be a key for the future search of individualized medicine.
authors.affiliation: Uppsala University, Department of Biochemistry and Organic Chemistry, Faculty of Technology and Science, Uppsala, Sweden; Imperial College, Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, London, UK; University of Southern Denmark, Institute of Clinical Research, Department of Nuclear Medicine, PET and Cyclotron Unit, Odense, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Långström
authors.forename: F
authors.initials: F
authors.lastname: Karimi
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis; D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry; D004295:Dihydroxyphenylalanine / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006207:Half-Life; D006801:Humans; D007553:Isotope Labeling; D053858:Metabolic Networks and Pathways; D009590:Nitrogen Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D009590:Nitrogen Radioisotopes; D019275:Radiopharmaceuticals; D004295:Dihydroxyphenylalanine
keywords: 11C-amino acids; carbohydrates; endogenous compounds; fatty acids; ketone bodies; neurotransmitters