title: Anti-diabetic activity of cassava cross-linked octenyl succinic maltodextrin in STZ-induced diabetic mice.
abstract: The effect of cassava cross-linked octenyl succinic maltodextrin (CCOMD) on diabetic mice was investigated in this study. For CCOMD-L (low dose) and CCOMD-H (high dose) groups, the body weights were recovered by 14.9% and 18.5%, respectively, which were significantly higher than that of model control group. It was also found that the blood glucose and insulin levels were ameliorated in the diabetic mice by the CCOMD diet. Moreover, the CCOMD diet decreased the plasma total cholesterol level (8.1-9.1%) and LDL cholesterol level (28.9-39.4%), and improved the plasma HDL cholesterol level (13.8-15.3%) and intestine short chain fatty acid content. The results indicated that CCOMD administration may be helpful for treating and preventing hyperlipidemia and hyperglycemia in diabetes.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China. Electronic address: wl0519@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Wuxi Cofco Engineering & Technology Co., Ltd., Wuxi 214036, Jiangsu, China.
authors.forename: Maoqiang
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Academy of State Administration of Grain, Beijing 100037, China.
authors.forename: Yingyao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: China National Research Institute of Food & Fermentation Industries, Beijing 100027, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Qi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D002365:Manihot / Q000737:chemistry*; D051379:Mice; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D013386:Succinates / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D005232:Fatty Acids, Volatile; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D011134:Polysaccharides; D013386:Succinates; C028480:octenyl succinate; C008315:maltodextrin
keywords: Blood glucose; Cassava cross-linked octenyl succinic maltodextrin; Diabetic mice