title: The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells.
abstract: The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating cells. In vitro, meddling with the expression of GPR37 affected the CAM-DR by regulating the ability of cell adhesion and the activity of Akt and ERK in MM cells. Further studies indicated the positive role of GPR37 in the proliferation of MM cells.
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xianting
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xun
authors.initials: X
authors.lastname: Nan
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China.
authors.forename: Xinxiu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Immunology, Medical College, Nantong University, Nantong, Jiangsu 226001, People's Republic of China. Electronic address: cheng_chun@yahoo.com.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Cheng
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D020935:MAP Kinase Signaling System; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: C480827:GPR37 receptor, human; D034741:RNA, Small Interfering; D043562:Receptors, G-Protein-Coupled; D051057:Proto-Oncogene Proteins c-akt
keywords: CAM-DR; GPR37; MAPK/ERK; PI3K/Akt; Proliferation