title: Management of extraglandular manifestations of primary Sjögren's syndrome.
abstract: Primary Sjögren's syndrome can have multiple extra-glandular manifestations ranging from mild to severe. Treatment for extra-glandular manifestations is organ specific and therapies are targeted based on the primary organs involved. Preferred treatment options used for extra-glandular manifestations of Sjögren's syndrome are usually extrapolated from the physician's experience in treating similar manifestations in other autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematous. The lack of immunomodulating disease modifying drugs in Sjögren's syndrome can be frustrating for patients dealing with extra-glandular manifestations, however recent advances in the field has made the future look promising for new therapeutic options.
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Department of Medicine, Winthrop University Hospital, Mineola, NY 11501, USA; Nassau University Medical Center, East Meadow, NY 11554, USA.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Wu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Carsons
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006801:Humans; D009140:Musculoskeletal Diseases / Q000209:etiology / Q000628:therapy*; D009422:Nervous System Diseases / Q000209:etiology / Q000628:therapy*; D012859:Sjogren's Syndrome / Q000150:complications*; D012871:Skin Diseases / Q000209:etiology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal
keywords: Anti-TNF; Joint pain; NSAIDs; Sjögren's syndrome