title: The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation.
abstract: Increased global connectivity has catalyzed technological development in almost all industries, in part through the facilitation of novel collaborative structures. Notably, open innovation and crowd-sourcing-of expertise and/or funding-has tremendous potential to increase the efficiency with which biomedical ecosystems interact to deliver safe, efficacious and affordable therapies to patients. Consequently, such practices offer tremendous potential in advancing development of cellular therapies. In this vein, the CASMI Translational Stem Cell Consortium (CTSCC) was formed to unite global thought-leaders, producing academically rigorous and commercially practicable solutions to a range of challenges in pluripotent stem cell translation. Critically, the CTSCC research agenda is defined through continuous consultation with its international funding and research partners. Herein, initial findings for all research focus areas are presented to inform global product development strategies, and to stimulate continued industry interaction around biomanufacturing, strategic partnerships, standards, regulation and intellectual property and clinical adoption.
authors.affiliation: 1 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford , Oxford, United Kingdom .
authors.forename: David A
authors.initials: DA
authors.lastname: Brindley
authors.forename: Anna
authors.initials: A
authors.lastname: French
authors.forename: Jane
authors.initials: J
authors.lastname: Suh
authors.forename: MacKenna
authors.initials: M
authors.lastname: Roberts
authors.forename: Benjamin
authors.initials: B
authors.lastname: Davies
authors.forename: Rafael
authors.initials: R
authors.lastname: Pinedo-Villanueva
authors.forename: Karolina
authors.initials: K
authors.lastname: Wartolowska
authors.forename: Kelly
authors.initials: K
authors.lastname: Rooke
authors.forename: Anneke
authors.initials: A
authors.lastname: Kramm
authors.forename: Andrew
authors.initials: A
authors.lastname: Judge
authors.forename: Mark
authors.initials: M
authors.lastname: Morrey
authors.forename: Amit
authors.initials: A
authors.lastname: Chandra
authors.forename: Hannah
authors.initials: H
authors.lastname: Hurley
authors.forename: Liam
authors.initials: L
authors.lastname: Grover
authors.forename: Ian
authors.initials: I
authors.lastname: Bingham
authors.forename: Bernard
authors.initials: B
authors.lastname: Siegel
authors.forename: Matt S
authors.initials: MS
authors.lastname: Rattley
authors.forename: R Lee
authors.initials: RL
authors.lastname: Buckler
authors.forename: David
authors.initials: D
authors.lastname: McKeon
authors.forename: Katie
authors.initials: K
authors.lastname: Krumholz
authors.forename: Lilian
authors.initials: L
authors.lastname: Hook
authors.forename: Michael
authors.initials: M
authors.lastname: May
authors.forename: Sarah
authors.initials: S
authors.lastname: Rikabi
authors.forename: Rosie
authors.initials: R
authors.lastname: Pigott
authors.forename: Megan
authors.initials: M
authors.lastname: Morys
authors.forename: Afsie
authors.initials: A
authors.lastname: Sabokbar
authors.forename: Emily
authors.initials: E
authors.lastname: Titus
authors.forename: Yacine
authors.initials: Y
authors.lastname: Laabi
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemaitre
authors.forename: Raymond
authors.initials: R
authors.lastname: Zahkia
authors.forename: Doug
authors.initials: D
authors.lastname: Sipp
authors.forename: Robert
authors.initials: R
authors.lastname: Horne
authors.forename: Christopher
authors.initials: C
authors.lastname: Bravery
authors.forename: David
authors.initials: D
authors.lastname: Williams
authors.forename: Ivan
authors.initials: I
authors.lastname: Wall
authors.forename: Evan Y
authors.initials: EY
authors.lastname: Snyder
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Karp
authors.forename: Richard W
authors.initials: RW
authors.lastname: Barker
authors.forename: Kim
authors.initials: K
authors.lastname: Bure
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Carr
authors.forename: Brock
authors.initials: B
authors.lastname: Reeve
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D018973:Intellectual Property; D039904:Pluripotent Stem Cells; D057905:Stem Cell Research / Q000331:legislation & jurisprudence*; D057170:Translational Research, Biomedical / Q000331:legislation & jurisprudence