title: Biotransformation, a promising technology for anti-cancer drug development.
abstract: With the high morbidity and mortality caused by cancer, finding new and more effective anti-cancer drugs is very urgent. In current research, biotransformation plays a vital role in the research and development of cancer drugs and has obtained some achievements. In this review, we have summarized four applications as follows: to exploit novel anti-cancer drugs, to improve existing anti-cancer drugs, to broaden limited anti-cancer drug resources and to investigate correlative mechanisms. Three different groups of important anti-cancer compounds were assessed to clarify the current practical applications of biotransformation in the development of anti-cancer drugs.
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan China E-mail : chaomeifu@126.com, hhlmedicine@126.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Zhang
authors.forename: Zhan-Guo
authors.initials: ZG
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Hu
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Fu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001711:Biotransformation / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents