title: Comparative proteomics analysis of mice lymphocytes in early stages of infection by different strains of rabies virus.
abstract: The CNS immune response to rabies virus has been shown to be influenced by virulence of the virus strains. There is no comprehensive report of the peripheral immune response against different strains of rabies virus. In this report we used a comparative proteome analysis to find the early events in the spleen lymphocytes of mice infected by a street strain and an attenuated strain of the rabies virus. Differentially expressed proteins were identified which play important biological roles such as T and B lymphocyte activation (coronin 1), antiviral activity (peroxiredoxin 1), and cytoskeletal reorganization (cofilin 1). These results could be strong hints of early divergence on peripheral immune response under influence of viral strain and their pathogenicity.
authors.affiliation: Protein Chemistry Unit, Biotechnology Research Center, Pasteur Institute of Iran, 69, Pasteur St, 13164 Tehran, Iran.
authors.forename: Behrouz
authors.initials: B
authors.lastname: Vaziri
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Torkashvand
authors.forename: Naser
authors.initials: N
authors.lastname: Eslami
authors.forename: Ahmad
authors.initials: A
authors.lastname: Fayaz
keywords: Comparative proteomics; Coronin 1; Rabies; Spleen lymphocyte