title: Local reactions from subcutaneous allergen immunotherapy.
abstract: Local reactions from subcutaneous allergen immunotherapy are very common during the course of immunotherapy. These local reactions are not bothersome to patients. Local reactions from immunotherapy also do not predict future local or systemic reactions. This review discusses the studies that show that local reactions are not predictive of future reactions and that dose adjustments for local reactions from allergen immunotherapy are unnecessary. The article also focuses on factors that lead to patient noncompliance with immunotherapy and evaluates methods to prevent local reactions from subcutaneous allergen immunotherapy.
authors.affiliation: Department of Allergy & Immunology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX, USA. christopher.coop@us.af.mil.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Coop
mesh_terms: D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D007073:Immunoglobulin E / Q000276:immunology; D007279:Injections, Subcutaneous; D012871:Skin Diseases / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000485:Allergens; D007073:Immunoglobulin E