title: Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and aggressive behavior in schizophrenia.
abstract: We investigated the association of the Val66Met gene polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene with aggressive behavior among Southern Han Chinese schizophrenia patients. We used polymerase chain reaction-restriction fragment length polymorphism to determine the genotypes and the Modified Overt Aggression Scale (MOAS) to measure aggressive behavior. No significant differences in genotype or allele distribution of Val66Met were identified between aggressive and non-aggressive schizophrenia patients.
authors.affiliation: School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Guan
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zai-Quan
authors.initials: ZQ
authors.lastname: Dong
authors.affiliation: Department of Anesthesia and Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Tian
authors.affiliation: School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Wu
authors.affiliation: Department of Forensic Psychiatry, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Forensic Psychiatry, Sichuan University, Chengdu, Sichuan, China. Electronic address: hezeqing@126.com.
authors.forename: Ze-Qing
authors.initials: ZQ
authors.lastname: Hu
authors.affiliation: School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China. Electronic address: medical8989@126.com.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000502:physiology* / Q000523:psychology; D000483:Alleles; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Aggression; Genetic association; Modified Overt Aggression Scale (MOAS)