title: Interleukin-6 polymorphism and prostate cancer risk in population of Eastern Croatia.
abstract: Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The -174G > C polymorphism of IL-6 gene has been associated with high IL-6 producer phenotype and an increased risk for CaP. The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP, in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p = 0.147). Also, no statistically significant difference in IL-6 high and low producer genotype frequency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 - 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibility. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP.
authors.affiliation: "J. J. Strossmayer" University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Mandić
authors.forename: Bojan
authors.initials: B
authors.lastname: Sudarević
authors.forename: Saska
authors.initials: S
authors.lastname: Marczi
authors.forename: Vesna
authors.initials: V
authors.lastname: Horvat
authors.forename: Ivan
authors.initials: I
authors.lastname: Cosić
authors.forename: Slobodan
authors.initials: S
authors.lastname: Mihaljević
authors.forename: Nevenka
authors.initials: N
authors.lastname: Milicević
authors.forename: Dalibor
authors.initials: D
authors.lastname: Simunović
authors.forename: Josip
authors.initials: J
authors.lastname: Galić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017523:Croatia / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6