title: Pathogenicity of clinical Acinetobacter baumannii isolates in a Galleria mellonella host model according to bla(OXA-40) gene and epidemiological outbreak status.
abstract: Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).
authors.affiliation: Chicago State University, Chicago, Illinois, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Esterly
authors.forename: Milena M
authors.initials: MM
authors.lastname: McLaughlin
authors.forename: Michael
authors.initials: M
authors.lastname: Malczynski
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
authors.forename: Teresa R
authors.initials: TR
authors.lastname: Zembower
authors.forename: Marc H
authors.initials: MH
authors.lastname: Scheetz
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D000818:Animals; D002641:Chicago / Q000453:epidemiology; D004196:Disease Outbreaks; D015870:Gene Expression; D006801:Humans; D007814:Larva / Q000382:microbiology*; D008954:Models, Biological; D009036:Moths / Q000382:microbiology*; D010957:Plasmids; D014774:Virulence; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics*
chemical_list: D001618:beta-Lactamases; C488541:beta-lactamase OXA-40, Acinetobacter baumannii