title: Elucidating the neurotoxicity of the star fruit.
abstract: Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.
authors.affiliation: Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil). ngcairas@fmrp.usp.br.
authors.forename: Norberto
authors.initials: N
authors.lastname: Garcia-Cairasco
authors.forename: Miguel
authors.initials: M
authors.lastname: Moyses-Neto
authors.forename: Flavio
authors.initials: F
authors.lastname: Del Vecchio
authors.forename: José A C
authors.initials: JA
authors.lastname: Oliveira
authors.forename: Francisco L
authors.initials: FL
authors.lastname: dos Santos
authors.forename: Olagide W
authors.initials: OW
authors.lastname: Castro
authors.forename: Gabriel M
authors.initials: GM
authors.lastname: Arisi
authors.forename: Márcio
authors.initials: M
authors.lastname: Dantas
authors.forename: Ruither O G
authors.initials: RO
authors.lastname: Carolino
authors.forename: Joaquim
authors.initials: J
authors.lastname: Coutinho-Netto
authors.forename: Andre L A
authors.initials: AL
authors.lastname: Dagostin
authors.forename: Marcelo C A
authors.initials: MC
authors.lastname: Rodrigues
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Leão
authors.forename: Samir A P
authors.initials: SA
authors.lastname: Quintiliano
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Silva
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gobbo-Neto
authors.forename: Norberto P
authors.initials: NP
authors.lastname: Lopes
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000818:Animals; D001688:Biological Products; D005517:Foodborne Diseases / Q000209:etiology*; D005638:Fruit / Q000737:chemistry* / Q000506:poisoning* / Q000633:toxicity; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D009498:Neurotoxins / Q000506:poisoning* / Q000633:toxicity*; D010947:Plants, Toxic / Q000737:chemistry* / Q000506:poisoning*; D051381:Rats; D017208:Rats, Wistar; D006435:Renal Dialysis
chemical_list: D001688:Biological Products; D009498:Neurotoxins
keywords: natural products; neurological agents; neurotoxins; receptors; star fruit