title: Primary neuroendocrine carcinoma of ocular adnexa.
abstract: We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological examination indicated that he had a primary NEC of the left lacrimal gland. He underwent chemotherapy followed by excision including the clinically visible margins and 50 Gy radiotherapy of the surgical margins. He had neither recurrence nor metastasis for 6 months since the last radiotherapy. An 80-year-old man noticed a nodule in the right upper eyelid and was referred to our hospital because the size was increasing rapidly. A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.
authors.affiliation: Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamanouchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Jiro
authors.initials: J
authors.lastname: Yotsukura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Asanagi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Baba
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nizawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yonemori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto