title: [Clinical efficacy and safety of megestrol acetate vaginal ring].
abstract: OBJECTIVE
  To explore the efficacy and safety of megestrol acetate silicone vaginal ring.
  
  
  METHODS
  A total of 165 healthy child-bearing age women were recruited to examine the efficacy, safety and satisfaction rate of megestrol acetate silicone vaginal ring.
  
  
  RESULTS
  The cumulative pregnancy rate of megestrol acetate silicone vaginal ring was 3.93%. And its discontinuation rate was 2.54%, the incidence of adverse events 11.52% and the incidence of adverse effects 1.81% while the symptoms were all slight. The bleeding pattern was similar to that of normal menstruation. Compared with baseline, the elevated level of triglycerides and the reduced level of low-density lipoprotein (LDL) were significantly different while no significant difference existed in high-density lipoprotein (HDL), cholesterol and hemoglobin, etc. The satisfaction rate of megestrol acetate silicone vaginal ring was 94.6% and increased with time.
  
  
  CONCLUSIONS
  Megestrol acetate silicone vaginal ring is an effective and safe option of contraceptives.
authors.affiliation: Department of Family Planning, Affiliated Obstetrics & Gynecology Hospital, Fudan University, Shanghai 200011, China.
authors.forename: Jin-feng
authors.initials: JF
authors.lastname: Qian
authors.forename: Xin-yi
authors.initials: XY
authors.lastname: Zhu
authors.forename: Yi-wen
authors.initials: YW
authors.lastname: Shen
authors.forename: Zi-rong
authors.initials: ZR
authors.lastname: Huang
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D003274:Contraceptive Devices, Female / Q000009:adverse effects; D005260:Female; D006801:Humans; D019290:Megestrol Acetate / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult
chemical_list: D019290:Megestrol Acetate