title: [Recent progress of small intestinal submucosa in application research of tissue repair and reconstruction].
abstract: OBJECTIVE
  To review the recent progress of the small intestinal submucosa (SIS) in application research of tissue repair and reconstruction.
  
  
  METHODS
  The domestic and international articles on the SIS were reviewed and summarized.
  
  
  RESULTS
  As a natural extracellular matrix, SIS has outstanding biological advantages, such as good mechanical property, tissue compatibility, and lower immunogenicity. SIS has been used to repair and reconstruct various types of tissue defects in animal models and clinical application, especially in the treatment of hernia, urinary system disease, and refractory skin trauma. The development of the tissue engineering technology expands the field of SIS repair and reconstruction and promotes the intensive study of SIS. However, the long-term effect of SIS in tissue repair and reconstruction still remains to be further observation, while the cell/SIS material construction by tissue engineering technology also needs more studies.
  
  
  CONCLUSIONS
  SIS has a widely promising application future in the tissue repair and reconstruction.
authors.affiliation: China Institute for Radiation Protection, Taiyuan Shanxi, 030006, P.R.China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Naili
authors.initials: N
authors.lastname: Zhang
authors.forename: Weijun
authors.initials: W
authors.lastname: Xu
authors.forename: Baoxing
authors.initials: B
authors.lastname: Li
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D019917:Blood Vessel Prosthesis Implantation; D006547:Hernia / Q000628:therapy*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000637:transplantation; D007421:Intestine, Small; D045164:Mesenchymal Stem Cell Transplantation; D019651:Plastic Surgery Procedures; D012038:Regeneration; D017695:Soft Tissue Injuries / Q000601:surgery; D023822:Tissue Engineering; D014570:Urologic Diseases / Q000601:surgery
chemical_list: D001672:Biocompatible Materials