title: Gene-environment interactions in heavy metal and pesticide carcinogenesis.
abstract: Cancer is a complex disease involving a sequence of gene-environment interactions. Lifestyle, genetics, dietary factors, and environmental pollutants can increase the risk of cancer. Gene-environment interactions have been studied by a candidate-gene approach focusing on metabolism, DNA repair, and apoptosis. Here, we review the influence of gene-environment interactions in carcinogenesis, with emphasis on heavy metal and pesticide exposures.
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: shamstabrez1@gmail.com.
authors.forename: Shams
authors.initials: S
authors.lastname: Tabrez
authors.affiliation: Division of Endocrinology, Department of Medicine, Feinberg School of Medicine Northwestern University, Chicago, USA.
authors.forename: Medha
authors.initials: M
authors.lastname: Priyadarshini
authors.affiliation: Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois, Chicago, USA.
authors.forename: Shubha
authors.initials: S
authors.lastname: Priyamvada
authors.affiliation: Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Saudi Arabia.
authors.forename: Mohd Shahnawaz
authors.initials: MS
authors.lastname: Khan
authors.affiliation: Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois, Chicago, USA.
authors.forename: Arivarasu
authors.initials: A
authors.lastname: Na
authors.affiliation: Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Syed Kashif
authors.initials: SK
authors.lastname: Zaidi
mesh_terms: D063646:Carcinogenesis / Q000139:chemically induced* / Q000235:genetics; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000506:poisoning*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D000075322:Heavy Metal Poisoning; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D010575:Pesticides / Q000506:poisoning*
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides
keywords: Environment; Gene; Heavy metals; Pesticides; Polymorphism