title: Avascular necrosis in a HIV patient receiving ritonavir and inhaled fluticasone.
abstract: We report a case of severe bilateral knee avascular necrosis in a HIV-positive man receiving ritonavir and inhaled fluticasone. This case highlights the need for a thorough medication history in patients on ritonavir-based antiretroviral therapy, especially where multiple prescribers are involved in the patient's care.
authors.affiliation: Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Pollett
authors.forename: B
authors.initials: B
authors.lastname: Graves
authors.forename: B
authors.initials: B
authors.lastname: Richards
authors.forename: C
authors.initials: C
authors.lastname: MacLeod
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D000068298:Fluticasone; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D019438:Ritonavir / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000730:Androstadienes; D017320:HIV Protease Inhibitors; D000068298:Fluticasone; D019438:Ritonavir
keywords: AIDS; HIV; antiretroviral therapy; avascular necrosis; drug interactions; inhaled fluticasone; ritonavir; toxicity