title: Dietary factors modulate Helicobacter-associated gastric cancer in rodent models.
abstract: Since its discovery in 1982, the global importance of Helicobacter pylori-induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, and the environmental conditions influencing the outcome of persistent H. pylori infection. Dietary factors in humans are increasingly recognized as being important factors in modulating progression and severity of H. pylori-induced gastric cancer. Studies using rodent models to verify and help explain mechanisms whereby various dietary ingredients impact disease outcome should continue to be extremely productive.
authors.affiliation: 1Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Fox
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Wang
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D003906:Developing Countries; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D005492:Folic Acid / Q000008:administration & dosage; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D051379:Mice; D012492:Salts / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000209:etiology / Q000382:microbiology* / Q000503:physiopathology
chemical_list: D004041:Dietary Fats; D012492:Salts; D005492:Folic Acid; D001205:Ascorbic Acid
keywords: Helicobacter felis; Helicobacter pylori; diet; gerbils; mice