title: Thiamin-dependent enzymes: new perspectives from the interface between chemistry and biology.
abstract: Identification and enzymological study of the multitude of thiamin (vitamin B1)-dependent enzymes open new ways to investigate metabolic regulation and disease treatments. The significant contribution of enzymes employing thiamin diphosphate as a coenzyme to solving medical and biotechnological problems is highlighted, together with the currently underestimated role of the enzymes in controlling the levels of the non-coenzyme thiamin derivatives.
authors.affiliation: A.N. Belozersky Institute of Physicochemical Biology and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Russia.
authors.forename: Victoria I
authors.initials: VI
authors.lastname: Bunik
mesh_terms: D000818:Animals; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D013379:Substrate Specificity; D013831:Thiamine / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D004798:Enzymes; D013831:Thiamine