title: Environments of B cell development.
abstract: B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Motokazu
authors.initials: M
authors.lastname: Tsuneto
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Kajikhina
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Seiler
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Reimer
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Tornack
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Corinne
authors.initials: C
authors.lastname: Bouquet
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Szandor
authors.initials: S
authors.lastname: Simmons
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Marko
authors.initials: M
authors.lastname: Knoll
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Wolf
authors.affiliation: German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
authors.forename: Koji
authors.initials: K
authors.lastname: Tokoyoda
authors.affiliation: German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Hauser
authors.affiliation: Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hara
authors.affiliation: Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Shizue
authors.initials: S
authors.lastname: Tani-ichi
authors.affiliation: Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ikuta
authors.affiliation: German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
authors.forename: Joachim R
authors.initials: JR
authors.lastname: Grün
authors.affiliation: German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Grützkau
authors.affiliation: Cellular and Molecular Immunology, University of Göttingen, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Engels
authors.affiliation: Cellular and Molecular Immunology, University of Göttingen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wienands
authors.affiliation: Department of Immunology, National Institutes of Infectious Diseases, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yanagisawa
authors.affiliation: Department of Immunology, National Institutes of Infectious Diseases, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohnishi
authors.affiliation: Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany. Electronic address: melchers@mpiib-berlin.mpg.de.
authors.forename: Fritz
authors.initials: F
authors.lastname: Melchers
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D005333:Fetus; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D038041:Lymphopoiesis / Q000502:physiology*
keywords: B cell development; Endothelial cells; Fetal liver; Mesenchymal cells