title: Homocysteine in dogs with systemic inflammatory response syndrome.
abstract: OBJECTIVE
  To compare serum concentrations of homocysteine in healthy dogs and those fitting the criteria for systemic inflammatory response syndrome and to compare these values to commonly measured B-vitamins.
  
  
  METHODS
  Study dogs were classified into non-infectious systemic inflammatory response syndrome or sepsis groups and blood was drawn on Day 1 of the patient's hospitalisation for measurement of serum homocysteine, folate and cobalamin concentrations. Homocysteine concentration was measured in 51 clinically healthy dogs to serve as the control group.
  
  
  RESULTS
  A statistically significant difference was found between the homocysteine concentrations of the healthy group when compared to non-infectious systemic inflammatory response syndrome and sepsis groups. Homocysteine values were not correlated with folate, cobalamin or APPLEfast severity scores. Homocysteine concentrations were significantly lower in sick dogs when compared to the control group, which is dissimilar to the human population.
  
  
  CONCLUSIONS
  The clinical significance of homocysteine changes in critically ill dogs is currently unknown.
authors.affiliation: Texas A&M College of Veterinary Medicine, College Station, TX, 77843, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Patterson
authors.forename: J W
authors.initials: JW
authors.lastname: Barr
authors.forename: G T
authors.initials: GT
authors.lastname: Fosgate
authors.forename: N
authors.initials: N
authors.lastname: Berghoff
authors.forename: J M
authors.initials: JM
authors.lastname: Steiner
authors.forename: J S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: D M
authors.initials: DM
authors.lastname: Black
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D008297:Male; D018805:Sepsis / Q000097:blood / Q000662:veterinary; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000662:veterinary*; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12