title: [Olfactory mucosa autograft for chronic complete spinal cord injury].
abstract: The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence of motor evoked potential (MEP) reflecting electrophysiological conductivity in the central nervous system, including the corticospinal pathway after OMA has not been clarified. We report the emergence of MEPs after OMA.
  
  
  METHODS
  Four patients, 3 men and 1 woman, were enrolled. The mean age of the cases was 30.3 ± 9.5 years (range, 19 to 40 years). All 4 cases were American Spinal Injury Association (ASISA) grade A. The mean duration from injury to OMA was 95. 8 ± 68.2 months (range, 17 to 300 months). Samples of olfactory mucosa were removed, cut into smaller pieces, and grafted into the sites of spinal cord lesions after laminectomy. Improvements in ASIA grade, variations in ASIA scores, EMG, SSEP, and improved urological function were evaluated as efficacy indicators.
  
  
  RESULTS
  There were no serious adverse events in this series. In 2 of the 4 cases, an improvement in motor function below the level of injury was recognized. The emergence of MEP was recognized in the latter case at 96 weeks after surgery.
authors.affiliation: Neurosurgery, Osaka University Medical School.
authors.forename: Koichi
authors.initials: K
authors.lastname: Iwatsuki
mesh_terms: D000328:Adult; D064592:Autografts; D002490:Central Nervous System / Q000503:physiopathology; D002908:Chronic Disease; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology; D009415:Nerve Net / Q000502:physiology; D009831:Olfactory Mucosa / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000534:rehabilitation* / Q000628:therapy*; D055815:Young Adult