title: What is the best strategy for enhancing the effects of topically applied ozonated oils in cutaneous infections?
abstract: Owing to diabetes, atherosclerosis, and ageing, there are several million patients undergoing skin lesions degenerated into infected ulcers with very little tendency to heal and implying a huge socioeconomical cost. Previous medical experience has shown that the daily application of ozonated oil eliminates the infection and promotes a rapid healing. The purpose of the study is the optimization of the antimicrobial effect of ozonated oils by testing in vitro four bacterial species and one yeast without or in the presence of different amounts of human serum. The results obtained suggest that a gentle and continuous removal of debris and exudate is an essential condition for the potent bactericidal effect of ozonated oils. In fact, even small amounts of human serum inactivate ozone derivatives and protect bacteria. The application of ozonated oil preparations is very promising in a variety of skin and mucosal infections. Moreover, ozonated oils are far less expensive than antibiotic preparations.
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Zanardi
authors.forename: S
authors.initials: S
authors.lastname: Burgassi
authors.forename: E
authors.initials: E
authors.lastname: Paccagnini
authors.forename: M
authors.initials: M
authors.lastname: Gentile
authors.forename: V
authors.initials: V
authors.lastname: Bocci
authors.forename: V
authors.initials: V
authors.lastname: Travagli
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development; D002176:Candida albicans / Q000254:growth & development; D003881:Dermatomycoses / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D010083:Oxidants, Photochemical / Q000737:chemistry*; D010126:Ozone / Q000737:chemistry*; D012715:Sesame Oil / Q000737:chemistry / Q000494:pharmacology; D017192:Skin Diseases, Bacterial / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000890:Anti-Infective Agents; D010083:Oxidants, Photochemical; D010126:Ozone; D012715:Sesame Oil