title: Effect of gold nanoparticles coated with plasma components on ADP-induced platelet aggregation.
abstract: We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.
authors.affiliation: Laboratory of Biophysical Bases of Pathology, Research Institute of Physicochemical Medicine, Russian Federal Medical Biological Agency, Moscow, Russia. aseychev@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Aseychev
authors.forename: O A
authors.initials: OA
authors.lastname: Azizova
authors.forename: E M
authors.initials: EM
authors.lastname: Beckman
authors.forename: L B
authors.initials: LB
authors.lastname: Dudnik
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000327:Adsorption; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001798:Blood Proteins / Q000737:chemistry*; D002478:Cells, Cultured; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D000244:Adenosine Diphosphate; D006046:Gold