title: Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.
abstract: Osteoporosis affects many patients with celiac disease (CD), representing the consequence of calcium malabsorption and persistent activation of mucosal inflammation. A slight increase of fracture risk is evident in this condition, particularly in those with overt malabsorption and in postmenopausal state. The adoption of a correct gluten-free diet (GFD) improves bone derangement, but is not able to normalize bone mass in all the patients. Biomarkers effective in the prediction of bone response to gluten-free diet are not yet available and the indications of guidelines are still imperfect and debated. In this review, the pathophysiology of bone loss is correlated to clinical aspects, defining an alternative proposal of management for this condition.
authors.affiliation: Department of Internal Medicine, University of Pavia, IRCCS "S.Matteo" Hospital Foundation, Pavia 27100, Italy. gr.corazza@smatteo.pv.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Di Stefano
authors.forename: Caterina
authors.initials: C
authors.lastname: Mengoli
authors.forename: Manuela
authors.initials: M
authors.lastname: Bergonzi
authors.forename: Gino Roberto
authors.initials: GR
authors.lastname: Corazza
mesh_terms: D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000503:physiopathology*; D002136:Calcium, Dietary / Q000378:metabolism*; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D055050:Diet, Gluten-Free; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D010024:Osteoporosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D015663:Osteoporosis, Postmenopausal / Q000209:etiology
chemical_list: D002136:Calcium, Dietary