title: Chlorinated didemnins from the tunicate Trididemnum solidum.
abstract: Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1-4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. ankisett@olemiss.edu.
authors.forename: Sridevi
authors.initials: S
authors.lastname: Ankisetty
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Bharathi
authors.initials: B
authors.lastname: Avula
authors.forename: Deborah
authors.initials: D
authors.lastname: Gochfeld
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: Marc
authors.initials: M
authors.lastname: Slattery
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology*; D054879:Halogenation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D047630:Depsipeptides; D016328:NF-kappa B; C030051:didemnins; D052247:Nitric Oxide Synthase Type II