title: Primary diffuse leptomeningeal gliomatosis mimicking tuberculous meningitis.
abstract: Primary diffuse leptomeningeal gliomatosis is a disease with an aggressive course that can result in death. To date, 82 cases have been reported. Here, the case of a 3-year-old male patient presenting with strabismus, headache, and restlessness is reported. Physical examination revealed paralysis of the left abducens nerve, neck stiffness, and bilateral papilledema. Tuberculous meningitis was tentatively diagnosed, and antituberculosis treatment was initiated when cranial imaging revealed contrast enhancement around the basal cistern. Craniocervical magnetic resonance imaging (MRI) was performed when there was no response to treatment, and it revealed diffuse leptomeningeal contrast enhancement around the basilar cistern, in the supratentorial and infratentorial compartments, and in the spinal region. Primary diffuse leptomeningeal gliomatosis was diagnosed by a meningeal biopsy.
authors.affiliation: Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Kosker
authors.affiliation: Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Dicle
authors.initials: D
authors.lastname: Sener
authors.affiliation: Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey omerkilic7@yahoo.com.
authors.forename: Omer
authors.initials: O
authors.lastname: Kilic
authors.affiliation: Division of Neuroradiology, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Zehra Isik
authors.initials: ZI
authors.lastname: Hasiloglu
authors.affiliation: Division of Neuroradiology, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Civan
authors.initials: C
authors.lastname: Islak
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kafadar
authors.affiliation: Division of Neuropathology, Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Sebnem
authors.initials: S
authors.lastname: Batur
authors.affiliation: Division of Neuropathology, Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Buge
authors.initials: B
authors.lastname: Oz
authors.affiliation: Division of Neuropathology, Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Cokugras
authors.affiliation: Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Necla
authors.initials: N
authors.lastname: Akcakaya
authors.affiliation: Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Camcioglu
mesh_terms: D002675:Child, Preschool; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis*; D009418:S100 Proteins / Q000378:metabolism; D014390:Tuberculosis, Meningeal / Q000503:physiopathology*
chemical_list: D003287:Contrast Media; D009418:S100 Proteins
keywords: children; glioma; leptomeningeal gliomatosis; tuberculous meningitis