title: [Experimental assessment of biodegradable polyglycolic and polylactic acid polymers for medical use].
abstract: Interrelations of biodegradable poliglicolic and polilactic acid polymers in various proportions implanted in standardized bone defects were evaluated in animal model with 40 Wister line rats. During 10 month follow-up period bone capsule surrounded all implants, but timing of bone formation and bone quality varied significantly being optimal in LactoSorb group. Destructive features of polymers were also seen in implant-bone contact area defined as inflammation, fibrous tissue formation and cell dystrophy.
authors.forename: A A
authors.initials: AA
authors.lastname: Kulakov
authors.forename: A S
authors.initials: AS
authors.lastname: Grigor'ian
authors.forename: A V
authors.initials: AV
authors.lastname: Arkhipov
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry; D018786:Bone Substitutes / Q000009:adverse effects* / Q000737:chemistry; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D005355:Fibrosis; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D019344:Lactic Acid / Q000009:adverse effects* / Q000737:chemistry; D008422:Materials Testing; D011091:Polyesters / Q000009:adverse effects* / Q000737:chemistry; D011100:Polyglycolic Acid / Q000009:adverse effects* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000009:adverse effects* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)