title: Differential toxic responses between pristine and functionalized multiwall nanotubes involve induction of autophagy accumulation in murine lung.
abstract: Carbon nanotubes (CNT) are becoming commonly used in industrial applications. However, the toxicity associated with this material remains to be established. The aim of this study was to investigate the potential toxic mechanisms associated with multiwall carbon nanotubes (MWCNT) in normal mouse lung. A total of 100 μg of two types of MWCNT, namely, pristine MWCNT (PMWCNT) and acid-treated-MWCNT (TMWCNT), was administered to male C57BL/6 mice via intratracheal (IT) instillation for a period of 6 mo. Our results indicated that PMWCNT induced pulmonary autophagy accumulation and resulted in more potent tumorigenic effects compared to TMWCNT. Accordingly, MWCNT may exert differential toxicity attributed to various physicochemical properties. Data emphasize the need for careful regulation of production and use of CNT.
authors.affiliation: a Laboratory of Toxicology, College of Veterinary Medicine , Seoul National University , Seoul , Korea.
authors.forename: Kyeong-Nam
authors.initials: KN
authors.lastname: Yu
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Hwi Won
authors.initials: HW
authors.lastname: Seo
authors.forename: Chanhee
authors.initials: C
authors.lastname: Chae
authors.forename: Myung-Haing
authors.initials: MH
authors.lastname: Cho
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D015153:Blotting, Western; D063646:Carcinogenesis / Q000139:chemically induced*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000633:toxicity*; D009389:Neovascularization, Pathologic / Q000139:chemically induced
chemical_list: D037742:Nanotubes, Carbon