title: Involuting luteinized thecoma of the ovary.
abstract: Spontaneous tumor involution in ovarian stromal tumors is a poorly understood phenomenon. In this report, we describe a rare case of luteinized thecoma that showed extensive involutional changes, such that cellular elements diagnostic of luteinized thecoma were sparse. The convoluted contour of the tumor resembled that observed in a corpus albicans; however, the neoplasm was considerably larger, and the contents of the nodule differed from that of a corpus albicans. The diagnosis of luteinized thecoma was established by the identification of residual aggregates of neoplastic theca cells and a nodule of lutein cells that were positive for inhibin and steroidogenic factor-1. Features of involution within the tumor included a few theca and lutein cells with pyknotic nuclei and abundant cytoplasmic lipid, occasional large adipocytes among the lutein cells, extensive hyalinization, dystrophic calcification, a myxohyaline nodule, and adipose metaplasia. It is likely that some of the aforementioned changes are the result of accompanying ischemia. Cleaved caspase-3 staining patterns were negative within residual lutein and theca cells; thus, we were unable to establish the occurrence of apoptotic bodies.
authors.affiliation: Departments of Pathology, Indiana University School of Medicine (L.M.R., G.E.S.), Indianapolis, Indiana Henry Ford Health System (A.R.G.), Detroit, Michigan University of California San Diego School of Medicine and Veterans Administration San Diego Healthcare System (M.D.L.), San Diego, California.
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Roth
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Gaba
authors.forename: Michael D
authors.initials: MD
authors.lastname: Linden
authors.forename: George E
authors.initials: GE
authors.lastname: Sandusky
mesh_terms: D005260:Female; D006801:Humans; D008184:Luteal Cells / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013798:Thecoma / Q000378:metabolism / Q000473:pathology*