title: The application of monoclonal antibodies in cancer diagnosis.
abstract: Cancer becomes the second leading cause of death in the world. An effective strategy for early diagnosis of the disease is key to reduce the mortality and morbidity. Development of effective monoclonal antibody (mAb)-based assays or diagnostic imaging techniques for detection of antigens and small molecules that are released from cancerous cells will enhance modern diagnostic medicine of cancer significantly. Although mAb technology is still under development, recent advances in preparation of recombinant antigen and antibody engineering techniques have dramatically enhanced the applications of this technology in cancer diagnosis. Compared with other methods, mAb-based assays may provide spatial, temporal, accurate and quantitative measurement for diagnosis of the disease. This review summarizes the progress of the mAb-based assays in the field of molecular diagnosis of cancer.
authors.affiliation: The Medical College of Dalian University, Dalian Economic & Technical Development Zone, Dalian 116622, People's Republic of China, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
authors.forename: Gamini
authors.initials: G
authors.lastname: Soori
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Dobleman
authors.forename: Gary G
authors.initials: GG
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000378:metabolism; D055088:Early Detection of Cancer; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor