title: Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis.
abstract: OBJECTIVE
  The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver cirrhosis in clinical practice.
  
  
  METHODS
  We collected preoperative information for 12 serum biochemical markers (ALB, PA, TBil, SCr, INR, ALT, AST, γ-GT, ALP, PT, APTT, and TT) from patients with liver cirrhosis, statistically analyzed the relationship between the serum biochemical markers and the extent of liver injury, and obtained the liver injury scoring formula using the matter element analysis method.
  
  
  RESULTS
  In our formula, the serum biochemical markers of patients with different degrees of liver cirrhosis damage led to different R-values, which represented the severity of the disease and the liver functional reserve. R=1 indicates that the liver tissue is normal; 0.770≤R<1 indicates that the liver is in the early stage of cirrhosis (SFLI I stage); 0.712≤R<0.770 indicates that the liver is in the intermediate state of compensated cirrhosis and decompensated cirrhosis (SFLI I+ stage); 0.629≤R<0.712 indicates that the liver is in the decompensated cirrhosis stage with ascites (SFLI II stage); 0.401≤R<0.629 indicates that the liver is in the stage of severely decompensated cirrhosis with ascites, and patients present with varying degrees of hepatic encephalopathy, hepatic coma, and other complications.
  
  
  CONCLUSIONS
  The SFLI that we constructed can sensitively and accurately reflect the conditions of liver cirrhosis damage and liver functional reserve.
authors.affiliation: Department of General Surgery, First College of Clinical Medical Science of China, Three Gorges University (Yichang Central People's Hospital), Yichang, Hubei, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Rongchun
authors.initials: R
authors.lastname: Xing
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D003661:Decision Support Techniques; D018450:Disease Progression; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010314:Partial Thromboplastin Time; D018579:Patient Selection; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011517:Prothrombin Time; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers