title: A new model for demonstrating enamel protection benefits relative to acid challenge.
abstract: OBJECTIVE
  To determine the applicability of a modified US FDA Caries Monograph test method for measuring the protective benefits of fluoride (F) against erosive, dietary acids.
  
  
  METHODS
  Acid-challenged teeth were treated in two studies with a dentifrice, rinsed, and then re-challenged in a series of tests using three dietary acids. Study 1 included dentifrices containing 1450 ppm F as sodium fluoride (NaF) + triclosan [A], 1450 ppm F (NaF) + potassium nitrate (KNO3) [B], 1000 ppm F as sodium monofluorophosphate (SMFP) [C], and 0 ppm F (placebo) [D]. Study 2 included dentifrices containing 1450 ppm F (NaF) [A]; and 0 ppm F (placebo) [B]. Acids were analyzed for phosphate removed during tooth challenges, with post-treatment results compared to baseline. Results were averaged and reported as a % protection value for each product, with higher values indicating greater protection.
  
  
  RESULTS
  Study 1: % protection for A = 16.4; B = 13.0; C = 7.1; and D = -5.2. Study 2: A = 15.2; B = -10.5, with A = B > C > D: Study 1; and A > B: Study 2. In each study, p < 0.05, ANOVA.
  
  
  CONCLUSIONS
  The model provides a viable tool for initially assessing the potential for fluoride-containing oral care products to protect teeth against erosive, dietary acids. This can then lead to further and more elaborate testing with reasonable expectations for outcomes.
authors.affiliation: Dental Product Testing, Noblesville, IN, USA. BSchemehorn@therametric.com
authors.forename: B R
authors.initials: BR
authors.lastname: Schemehorn
authors.forename: G D
authors.initials: GD
authors.lastname: Wood
authors.forename: S L
authors.initials: SL
authors.lastname: Eversole
authors.forename: R V
authors.initials: RV
authors.lastname: Faller
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D019343:Citric Acid / Q000009:adverse effects; D003124:Colorimetry; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use*; D004032:Diet; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use; D010710:Phosphates / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D010919:Placebos; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D013644:Tartrates / Q000009:adverse effects; D014077:Tooth Erosion / Q000517:prevention & control*; D014260:Triclosan / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D009566:Nitrates; D010710:Phosphates; D010919:Placebos; D017680:Potassium Compounds; D020011:Protective Agents; D013644:Tartrates; C012980:fluorophosphate; D019343:Citric Acid; D014260:Triclosan; D012969:Sodium Fluoride; D019342:Acetic Acid; D005459:Fluorides; C023844:potassium nitrate; C029768:tartaric acid