title: Efficacy of the enamel matrix derivative in direct pulp capping procedures: a systematic review.
abstract: The aim was to review the efficacy of the enamel matrix derivative (EMD) in direct pulp capping (DPC) procedures. Databases were explored using the following keywords: 'dental', 'dentine', 'enamel matrix derivative', 'pulp capping' and 'treatment'. The inclusion criteria were: (i) original studies; (ii) human and animal studies; (iii) reference list of potentially relevant original and review articles; (iv) intervention: effect of EMD on pulp-capping procedures; and (v) articles published only in English. Eight studies (four human and four animal) were included. Among the human studies, two studies reported that EMD is a more efficient DPC procedure compared with calcium hydroxide (Ca(OH)2 ). One study reported Ca(OH)2 to be more efficient for DPC than EMD. One study reported no difference in the efficacies between EMD and Ca(OH)2 for DPC. All animal studies reported EMD to be more effective in reparative dentine formation in comparison with Ca(OH)2 . EMD can provide favourable results in DPC procedures.
authors.affiliation: Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Lab, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Division of Endodontics, King Abdulaziz Medical City, National Guard Hospital, Riyadh, Saudi Arabia Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, Georgia, USA.
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hezaimi
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Fouzan
authors.forename: Franklin
authors.initials: F
authors.lastname: Tay
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003785:Dental Pulp Capping / Q000379:methods*; D003809:Dentin, Secondary / Q000187:drug effects; D006801:Humans; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; D057872:Pulp Capping and Pulpectomy Agents; C109069:enamel matrix proteins; D002126:Calcium Hydroxide
keywords: dental; dentine; direct pulp capping; enamel matrix derivative; treatment