title: Antibody-mediated functional control of a dansylated polytheonamide mimic.
abstract: We demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal anti-dansyl antibody (anti-dansyl IgG). The IgG effectively suppressed the ion transport activity and cytotoxicity of 2 in a dose-dependent manner.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. inoue@mol.f.u-tokyo.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047908:Intracellular Signaling Peptides and Proteins; D017136:Ion Transport / Q000187:drug effects; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry / Q000276:immunology*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: C496906:1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine; D000906:Antibodies; D001672:Biocompatible Materials; D047908:Intracellular Signaling Peptides and Proteins; D010455:Peptides; D010713:Phosphatidylcholines; D011506:Proteins; C111717:polytheonamide B