title: Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery.
abstract: The plasma membrane as a selectively permeable barrier of living cells is essential to cell survival and function. In many cases, however, the efficient passage of exogenous bioactive molecules through the plasma membrane remains a major hurdle for intracellular delivery of cargoes. During the last two decades, the potential of peptides for drug delivery into cells has been highlighted by the discovery of numerous cell-penetrating peptides (CPPs). CPPs serving as carriers can successfully intracellular transport cargoes such as siRNA, nucleic acids, proteins, small molecule therapeutic agents, quantum dots and MRI contrast agents. This review mainly introduces recent advances of CPPs as new carriers for the development of cellular imaging, nuclear localization, pH-sensitive and thermally targeted delivery systems. In particular, we highlight the exploiting of the synergistic effects of targeting ligands and CPPs. What's more, the classification and cellular uptake mechanisms of CPPs are briefly discussed as well.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China; Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan Beiyi Road, Shanghai 200437, PR China.
authors.forename: Feihu
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China. Electronic address: srguo@sjtu.edu.cn.
authors.forename: Shengrong
authors.initials: S
authors.lastname: Guo
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan Beiyi Road, Shanghai 200437, PR China. Electronic address: jfsipi@163.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Jin
mesh_terms: D000818:Animals; D001692:Biological Transport; D057846:Cell-Penetrating Peptides / Q000145:classification / Q000494:pharmacology; D004337:Drug Carriers; D018014:Gene Transfer Techniques; D006801:Humans
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers
keywords: Biomedical applications; Carrier; Cell penetrating peptides; Cellular uptake mechanisms; Drug delivery