title: Perfluoroalkanesulfonamide organocatalysts for asymmetric conjugate additions of branched aldehydes to vinyl sulfones.
abstract: Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.
authors.affiliation: Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. tmiura@toyaku.ac.jp.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nakashima
authors.forename: Miho
authors.initials: M
authors.lastname: Murahashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yuasa
authors.forename: Mariko
authors.initials: M
authors.lastname: Ina
authors.forename: Norihiro
authors.initials: N
authors.lastname: Tada
authors.forename: Akichika
authors.initials: A
authors.lastname: Itoh
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Hirashima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koseki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miura
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013449:Sulfonamides / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D013449:Sulfonamides; D013450:Sulfones; C009873:divinyl sulfone