title: [Vitamin B9].
abstract: Vitamin B9 is represented by the group of folate, whose structure is derived from folic acid. The biologically active form is reduced tetrahydrofolates, serving as an essential cofactor in methylation reactions, including the vitamin B12-dependent formation of methionine from homocysteine, and as a carrier of one-carbon units involved in the synthesis of purines and pyrimidines. Folate deficiency is associated with hyperhomocysteinemia, megaloblastic anemia, leuco- and thrombocytopenia, cardiovascular disease, embryonic defects, in particular neural tube defects, and, possibly, malignancies, depression and cognitive impairment.
authors.affiliation: Laboratoire de biochimie spécialisée, plateau technique de biologie, CHU de Dijon, 2170 Dijon Cedex, France. jean-claude.guilland@chu-dijon.fr
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Guilland
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aimone-Gastin
mesh_terms: D005260:Female; D005492:Folic Acid / Q000502:physiology*; D005494:Folic Acid Deficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D005492:Folic Acid