title: Tunable visible and near-IR photoactivation of light-responsive compounds by using fluorophores as light-capturing antennas.
abstract: Although the corrin ring of vitamin B12 is unable to efficiently absorb light beyond 550 nm, it is shown that commercially available fluorophores can be used as antennas to capture long-wavelength light to promote scission of the Co-C bond at wavelengths up to 800 nm. The ability to control the molecular properties of bioactive species with long visible and near-IR light has implications for drug delivery, nanotechnology, and the spatiotemporal control of cellular behavior.
authors.affiliation: Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA). tshell@email.unc.edu.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Shell
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Shell
authors.forename: Zachary L
authors.initials: ZL
authors.lastname: Rodgers
authors.forename: David S
authors.initials: DS
authors.lastname: Lawrence
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004735:Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008027:Light; D018613:Microscopy, Confocal; D010782:Photolysis; D051381:Rats; D012235:Rhodamines / Q000737:chemistry; D014805:Vitamin B 12 / Q000737:chemistry
chemical_list: C437523:5-carboxytetramethylrhodamine; D005456:Fluorescent Dyes; D012235:Rhodamines; D004317:Doxorubicin; D014805:Vitamin B 12
keywords: cobalamins; drug delivery; energy transfer; fluorescence; photochemistry