title: Reduced salience and default mode network activity in women with anorexia nervosa.
abstract: BACKGROUND
  The neurobiology of anorexia nervosa is poorly understood. Neuronal networks contributing to action selection, self-regulation and interoception could contribute to pathologic eating and body perception in people with anorexia nervosa. We tested the hypothesis that the salience network (SN) and default mode network (DMN) would show decreased intrinsic activity in women with anorexia nervosa and those who had recovered from the disease compared to controls. The basal ganglia (BGN) and sensorimotor networks (SMN) were also investigated.
  
  
  METHODS
  Between January 2008 and January 2012, women with restricting-type anorexia nervosa, women who recovered from the disease and healthy control women completed functional magnetic resonance imaging during a conditioned stimulus task. Network activity was studied using independent component analysis.
  
  
  RESULTS
  We studied 20 women with anorexia nervosa, 24 recovered women and 24 controls. Salience network activity in the anterior cingulate cortex was reduced in women with anorexia nervosa (p = 0.030; all results false-discovery rate- corrected) and recovered women (p = 0.039) compared to controls. Default mode network activity in the precuneus was reduced in women with anorexia compared to controls (p = 0.023). Sensorimotor network activity in the supplementary motor area (SMA; p = 0.008), and the left (p = 0.028) and right (p = 0.002) postcentral gyrus was reduced in women with anorexia compared to controls; SMN activity in the SMA (p = 0.019) and the right postcentral gyrus (p = 0.008) was reduced in women with anorexia compared to recovered women. There were no group differences in the BGN.
  
  
  CONCLUSIONS
  Differences between patient and control populations (e.g., depression, anxiety, medication) are potential confounds, but were included as covariates.
  
  
  CONCLUSIONS
  Reduced SN activity in women with anorexia nervosa and recovered women could be a trait-related biomarker or illness remnant, altering the drive to approach food. The alterations in the DMN and SMN observed only in women with anorexia nervosa suggest state-dependent abnormalities that could be related to altered interoception and body image in these women when they are underweight but that remit following recovery.
authors.affiliation: Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo., USA.
authors.forename: Kristina L
authors.initials: KL
authors.lastname: McFadden
authors.affiliation: Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo., USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Tregellas
authors.affiliation: Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo., USA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Shott
authors.affiliation: Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo., USA.
authors.forename: Guido K W
authors.initials: GK
authors.lastname: Frank
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D012201:Reward; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult