title: [Heat stroke related to the use of topiramate. The importance of prevention].
abstract: Heat stroke is the most severe pathology related to heat. It is defined as an increase in core body temperature accompanied by signs of neurological dysfunction. In the absence of an early treatment, it has a very high mortality rate. Topiramate is a well known drug widely used in epilepsy treatment and migraine prevention. Oligohydrosis has been described amongst topiramate side effects, favouring the risk of hyperthermia and heatstroke. We present the case of a patient who developed heat stroke due to physical exercise while under topiramate treatment.
authors.affiliation: Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address: mrosichdc@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Rosich Del Cacho
authors.affiliation: Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors.forename: J
authors.initials: J
authors.lastname: Pareja Grande
authors.affiliation: Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors.forename: M D
authors.initials: MD
authors.lastname: Martínez Jiménez
authors.affiliation: Servicio de Pediatría, Hospital Virgen de Altagracia de Valdepeñas, Ciudad Real, España.
authors.forename: J F
authors.initials: JF
authors.lastname: Latorre Latorre
authors.affiliation: Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors.forename: N
authors.initials: N
authors.lastname: Bejarano Ramírez
authors.affiliation: Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors.forename: C
authors.initials: C
authors.lastname: López-Menchero Oliva
mesh_terms: D002648:Child; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D018883:Heat Stroke / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D000077236:Topiramate
chemical_list: D000077236:Topiramate; D005632:Fructose
keywords: Golpe de calor; Heat stroke; Hipohidrosis; Oligohydrosis; Topiramate; Topiramato