title: Anti-Müllerian hormone levels in women with polycystic ovarian syndrome compared with normal women of reproductive age in China.
abstract: OBJECTIVE
  Aim was to evaluate anti-Müllerian-hormone (AMH) in women with polycystic ovary syndrome (PCOS) comparing with normo-ovulatory women, and to assess for the first time AMH levels across reproductive lifespan in Chinese women.
  
  
  METHODS
  Within the prospective cross-sectional study in PCOS cases and in normal subjects, AMH and other hormone levels were measured in early follicular phase in five age groups. Additionally ovarian ultrasound parameters were assessed.
  
  
  RESULTS
  A total of 437 PCOS patients and 150 normo-ovulatory women matched by age were included. AMH levels were 2- to 3-fold higher in PCOS cases. In both groups AMH decreased with age in a non-linear pattern. In normo-ovulatory women AMH levels were relatively constant from 18 to 25 years and then declined with age. In contrast, AMH in PCOS cases declined with an increasing rate from 18 to 45 years, narrowing the difference in older women.
  
  
  CONCLUSIONS
  AMH may be a useful parameter to assess the severity and prognosis of PCOS since certain differences exist to normo-ovulatory women. Further studies may improve the understanding of the relationship between AMH levels and age, providing more scientific basis for fertility counselling for both healthy women and PCOS cases.
authors.affiliation: Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Xuanxuan
authors.initials: X
authors.lastname: Tian
authors.forename: Xiangyan
authors.initials: X
authors.lastname: Ruan
authors.forename: Alfred O
authors.initials: AO
authors.lastname: Mueck
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Shunyu
authors.initials: S
authors.lastname: Liu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yin
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.forename: Hongqin
authors.initials: H
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone