title: A mathematical model of long-term renal sympathetic nerve activity inhibition during an increase in sodium intake.
abstract: It is well known that renal nerves directly affect renal vascular resistance, tubular sodium reabsorption, and renin secretion. Inhibition of renal sympathetic nerve activity (RSNA) decreases renal vascular resistance, tubular sodium reabsorption, and renin secretion, leading to an increase in sodium excretion. Although several studies show that inhibition of RSNA promotes sodium excretion during an acute blood volume expansion, there is limited research relating to the importance of RSNA inhibition that contributes to sodium homeostasis during a long-term increase in sodium intake. Therefore, to dissect the underlying mechanisms of sodium excretion, a mathematical model of a cardiovascular system consisting of two kidneys, each with an independent RSNA, was developed. Simulations were performed to determine the responses of RSNA and sodium excretion to an increased sodium intake. In these simulations, RSNA in the left kidney was fixed at its normal steady-state value, while RSNA in the contralateral kidney was allowed to change normally in response to the increased sodium intake. The results demonstrate that the fixed-RSNA kidney excretes less sodium than the intact-RSNA collateral kidney. Because each kidney is exposed to the same arterial pressure and circulatory hormones, the impaired sodium excretion in the absence of RSNA inhibition supports the hypothesis that RSNA inhibition contributes to natriuresis in response to a long-term increase in sodium intake.
authors.affiliation: Department of Physiology and Biophysics, Center for Computational Medicine, University of Mississippi Medical Center, Jackson, Mississippi; and.
authors.forename: Fatih
authors.initials: F
authors.lastname: Karaaslan
authors.forename: Yagmur
authors.initials: Y
authors.lastname: Denizhan
authors.forename: Robert
authors.initials: R
authors.lastname: Hester
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D008955:Models, Cardiovascular; D009318:Natriuresis / Q000502:physiology*; D012982:Sodium, Dietary; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D012982:Sodium, Dietary
keywords: homeostasis; kidney; simulation