title: Effect of flubendiamide, lead and their combined exposure on erythrocytic indices in water buffalo calves.
abstract: This study evaluated the effect of flubendiamide, lead and their combined oral administration on erythrocytic indices in water buffalo calves. Exposure to flubendiamide alone resulted in non-significant decreases in Hemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Lead acetate exposure resulted in significant declines in Hb, PCV and TEC. Combined exposure to flubendiamide and lead resulted in declines in Hb, TEC and PCV, but values did not differ significantly from corresponding values in the group treated with lead alone. Changes in MCV, MCHC and MCH were inconsistent. Plasma calcium concentration declined on day 90 in lead-exposed animals, but increased again on day 30 post-treatment. Results of the present study indicated that flubendiamide exposure results in marginal alterations in erythrocytic indices, but lead exposure caused significant declines in Hb, PCV and TEC. No interactive effects were observed for flubendiamide and lead on changes in erythrocytic indices.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India, amita_pharma@rediffmail.com.
authors.forename: Amita
authors.initials: A
authors.lastname: Ranjan
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Dumka
authors.forename: Nittin Dev
authors.initials: ND
authors.lastname: Singh
mesh_terms: D000818:Animals; D001549:Benzamides / Q000633:toxicity*; D002020:Buffaloes / Q000502:physiology*; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006400:Hematocrit; D007306:Insecticides / Q000633:toxicity*; D007854:Lead / Q000633:toxicity*; D013450:Sulfones / Q000633:toxicity*; D005466:Fluorocarbons; D010797:Phthalimides
chemical_list: D001549:Benzamides; D007306:Insecticides; D007854:Lead; D013450:Sulfones; C508762:flubendiamide; D005466:Fluorocarbons; D010797:Phthalimides