title: The chromosome-centric human proteome project at FEBS Congress.
abstract: In the summer of 2013, distinguished global representatives of proteome science gathered to discuss the futuristic visions of the chromosome-centric human proteome project (C-HPP) (Cochairs: Y. K. Paik, G. Omenn; hosted by A. Archakov, Institute of Biomedical Chemistry, Russia) that was broadcast to the annual Federation of European Biochemical Societies Congress (St. Petersburg, Russia, July 10-11, 2013). Technology breakthroughs presented included a new ultra-sensitive Tribrid mass-spectrometer from Thermo and SOMAmers-Slow Off-rate Modified Aptamers (SOMAlogic, USA), a new type of protein capture reagents. Professor Archakov's group introduced the "rectangle" concept of proteome size as a product of proteome width and depth. The discussion on proteome width culminated with the introduction of digital biomarkers-low-copied aberrant proteins that differ from their typical forms by PTMs, alternative splicing, or single amino acid polymorphisms. The aberrant proteoforms, a complement to whole-genome proteomic surveys, were presented as an ultimate goal for the proteomic community.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia; RHUPO, Russian Human Proteome Organization, Moscow, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Ponomarenko
authors.forename: Ancha
authors.initials: A
authors.lastname: Baranova
authors.forename: Andrey
authors.initials: A
authors.lastname: Lisitsa
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Albar
authors.forename: Alexander
authors.initials: A
authors.lastname: Archakov
mesh_terms: D000818:Animals; D002877:Chromosomes, Human / Q000235:genetics*; D016045:Human Genome Project; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D020543:Proteome / Q000032:analysis / Q000235:genetics*; D040901:Proteomics / Q000379:methods*; D012426:Russia
chemical_list: D020543:Proteome
keywords: Digital biomarkers; Human Proteome Project; Proteome depth; Proteome width; Technology