title: Frontal gamma noise power and cognitive domains in schizophrenia.
abstract: The cognitive deficit profile is different among individuals with schizophrenia. We quantified the amount of electroencephalographic activity unlocked to stimuli onset (noise power) over frontal regions regarding deficit in cognitive domains. Forty-six patients with schizophrenia and 27 healthy controls underwent clinical, cognitive and electrophysiological assessments. Noise power studies may be considered complementary but not equivalent to induced power studies. We compared gamma and theta noise power magnitude during a P300 paradigm between subsets of patients divided according to cognitive deficit in key domains and controls. Patients displayed higher gamma noise power activity at Fz site and significantly lower performance in all cognitive domains when compared to controls. The subset of patients with cognitive deficit for working memory and problem solving/executive functions domains displayed significantly higher frontal-lateral noise power values in comparison to the subset of patients without cognitive deficit and controls. Patients with significant cognitive deficits in domains with greater frontal contribution are also characterized by an abnormally higher gamma band noise power over the frontal region. Our data may endorse various biological subsets within schizophrenia, characterized by the presence or absence of a significant cognitive deficit in frontal domains.
authors.affiliation: Mental Health Sciences Unit, Faculty of Brain Sciences, University College London, United Kingdom.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Díez
authors.affiliation: Institute of Biomedical Research (IBSAL), Salamanca, Spain; Neuroscience Institute of Castilla y León, University of Salamanca, Salamanca, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Suazo
authors.affiliation: UCM-ISCIII Center for Human Evolution and Behavior, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Casado
authors.affiliation: UCM-ISCIII Center for Human Evolution and Behavior, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Martín-Loeches
authors.affiliation: Basic Psychology, Psychobiology and Methodology Department, School of Psychology, University of Salamanca, Salamanca, Spain.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Perea
authors.affiliation: Institute of Biomedical Research (IBSAL), Salamanca, Spain; Neuroscience Institute of Castilla y León, University of Salamanca, Salamanca, Spain; Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain; Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain. Electronic address: vmolina@med.uva.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography / Q000379:methods*; D056344:Executive Function / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D009622:Noise; D011340:Problem Solving; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012565:Schizophrenic Psychology
keywords: Executive functions; Frontal lobe; Gamma band; Noise power; Schizophrenia; Theta band