title: A cognitive framework for understanding and improving interference resolution in the brain.
abstract: All of us are familiar with the negative impact of interference on achieving our task goals. We are referring to interference by information, which either impinges on our senses from an external environmental source or is internally generated by our thoughts. Informed by more than a decade of research on the cognitive and neural processing of interference, we have developed a framework for understanding how interference impacts our neural systems and especially how it is regulated and suppressed during efficient on-task performance. Importantly, externally and internally generated interferences have distinct neural signatures, and further, distinct neural processing emerges depending on whether individuals must ignore and suppress the interference, as for distractions, or engage with them in a secondary task, as during multitasking. Here, we elaborate on this cognitive framework and how it changes throughout the human lifespan, focusing mostly on research evidence from younger adults and comparing these findings to data from older adults, children, and cognitively impaired populations. With insights gleaned from our growing understanding, we then describe three novel translational efforts in our lab directed at improving distinct aspects of interference resolution using cognitive training. Critically, these training approaches were specifically developed to target improved interference resolution based on neuroplasticity principles and have shown much success in randomized controlled first version evaluations in healthy aging. Our results show not only on-task training improvements but also robust generalization of benefit to other cognitive control abilities. This research showcases how an in-depth understanding of neural mechanisms can then inform the development of effective deficit-targeted interventions, which can in turn benefit both healthy and cognitively impaired populations.
authors.affiliation: Departments of Neurology, Physiology and Psychiatry, University of California, San Francisco, CA, USA. Electronic address: jyoti@gazzaleylab.ucsf.edu.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Mishra
authors.forename: Joaquin A
authors.initials: JA
authors.lastname: Anguera
authors.forename: David A
authors.initials: DA
authors.lastname: Ziegler
authors.forename: Adam
authors.initials: A
authors.lastname: Gazzaley
mesh_terms: D000375:Aging / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*
keywords: aging; attention; cognitive control; cognitive training; distraction; interference; multitasking; neuroplasticity