title: Effects of vinpocetine and ozagrel on behavioral recovery of rats after global brain ischemia.
abstract: Brain ischemia leads to severe disruption of the nervous system and recovery is often prolonged. Rehabilitative post-ischemia pharmacological treatment may therefore be important for behavioral recovery, especially for cognition and motor behavior. The present study investigated the effects of combined vinpocetine and ozagrel administration on the behavioral recovery of rats from global brain ischemia. The results suggest that the combined treatment leads to significantly better improvement compared to single drug administration. We conclude that the combined use of vinpocetine and ozagrel may provide beneficial effects to patients suffering from brain ischemia.
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Jincai
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China. Electronic address: tingfang_dong@163.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Tingfang
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yongheng
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhongmin
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Zhai
authors.initials: Z
authors.lastname: Kaihua
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Xiaohong
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008689:Methacrylates / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009483:Neuropsychological Tests; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D008689:Methacrylates; D018696:Neuroprotective Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; C034364:ozagrel
keywords: Behavior; Brain ischemia; Ozagrel; Pharmacology; Rat; Vinpocetine