title: MODELING AIRWAY PROBABILITY.
abstract: We present a probability model for lung airways in computed tomography (CT) images. Lung airways are tubular structures that display specific features, such as low intensity and proximity to vessels and bronchial walls. From these features, the posterior probability for the airway feature space was computed using a Bayesian model based on 20 CT images from subjects with different degrees of Chronic Obstructive Pulmonary Disease (COPD). The likelihood probability was modeled using both a Gaussian distribution and a nonparametric kernel density estimation method. After exhaustive feature selection, good specificity and sensitivity were achieved in a cross-validation study for both the Gaussian (0.83, 0.87) and the nonparametric method (0.79, 0.89). The model generalizes well when trained using images from a late stage COPD group. This probability model may facilitate airway extraction and quantitative assessment of lung diseases, which is useful in many clinical and research settings.
authors.affiliation: Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
authors.forename: Rina D
authors.initials: RD
authors.lastname: Rudyanto
authors.forename: Arrate
authors.initials: A
authors.lastname: Muñoz-Barrutia
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Diaz
authors.forename: James
authors.initials: J
authors.lastname: Ross
authors.forename: George R
authors.initials: GR
authors.lastname: Washko
authors.forename: Carlos
authors.initials: C
authors.lastname: Ortiz-de-Solorzano
authors.forename: Raul San Jose
authors.initials: RS
authors.lastname: Estepar
keywords: CT; airway segmentation; chronic obstructive pulmonary disease; lung; probability model