title: Optical imaging of resting-state functional connectivity in a novel arterial stiffness model.
abstract: This study aims to assess the impact of unilateral increases in carotid stiffness on cortical functional connectivity measures in the resting state. Using a novel animal model of induced arterial stiffness combined with optical intrinsic signals and laser speckle imaging, resting state functional networks derived from hemodynamic signals are investigated for their modulation by isolated changes in stiffness of the right common carotid artery. By means of seed-based analysis, results showed a decreasing trend of homologous correlation in the motor and cingulate cortices. Furthermore, a graph analysis indicated a randomization of the cortex functional networks, suggesting a loss of connectivity, more specifically in the motor cortex lateral to the treated carotid, which however did not translate in differentiated metabolic activity.
authors.affiliation: Department of Electrical Engineering, École Polytechnique de Montréal, 2500 Chemin de Polytechnique, Montréal, Qc, H3C 3A7 Canada ; Research Center, Montreal Heart Institute, 5000 Bélanger Est, Montréal, Qc, H3T 1J4, Canada.
authors.forename: Edgar
authors.initials: E
authors.lastname: Guevara
authors.forename: Nataliya
authors.initials: N
authors.lastname: Sadekova
authors.forename: Hélène
authors.initials: H
authors.lastname: Girouard
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lesage
keywords: (110.4234) Multispectral and hyperspectral imaging; (110.6150) Speckle imaging