title: Quantification of photocatalytic oxygenation of human blood.
abstract: Photocatalytic oxygenation of human blood is an emerging concept based on the principle of photocatalytic splitting of water into oxygen and hydrogen. This communication reports: (i) a design of a photocatalytic cell (PC) that separates the blood from UV (incident) radiation source, (ii) a pH, temperature and flow controlled circuit designed for quantifying the oxygenation of human blood by photocatalysis and (iii) measuring the current efficacy of ITO/TiO2 nano thin films in oxygenating human blood in a dynamic circuit in real time. The average increase in oxygen saturation was around 5% above baseline compared to control (p<0.0005). We believe this is one of the first attempts to quantify photocatalytic oxygenation of human blood under controlled conditions.
authors.affiliation: Department of Physics, Indian Institute of Technology - Madras, Chennai, India.
authors.forename: Aryasomayajula
authors.initials: A
authors.lastname: Subrahmanyam
authors.affiliation: Department of Physics, Indian Institute of Technology - Madras, Chennai, India; Department of Cardiothoracic Surgery, Apollo Hospital, Chennai, India. Electronic address: paulramesh@gmail.com.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Thangaraj
authors.affiliation: Department of Physics, Indian Institute of Technology - Madras, Chennai, India.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Kanuru
authors.affiliation: Department of Perfusion, Apollo Hospital, Chennai, India.
authors.forename: Albert
authors.initials: A
authors.lastname: Jayakumar
authors.affiliation: Department of Endocrinology, Apollo Hospital, Chennai, India.
authors.forename: Jayashree
authors.initials: J
authors.lastname: Gopal
mesh_terms: D001784:Blood Gas Analysis / Q000295:instrumentation*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007204:Indium / Q000737:chemistry; D036103:Nanotechnology; D010100:Oxygen / Q000097:blood*; D055668:Photochemical Processes; D010777:Photochemistry / Q000295:instrumentation*; D013696:Temperature; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D007204:Indium; C009495:titanium dioxide; C047711:indium oxide; D014025:Titanium; D010100:Oxygen
keywords: Oxygenation of human blood; Photocatalysis; Prototype PC cell; Prototype circuit; Quantification