title: HLA-DPB1 and anti-HBs titer kinetics in hepatitis B booster recipients who completed primary hepatitis B vaccination during infancy.
abstract: Previously we reported significant associations of the human leukocyte antigen (HLA)-DPB1 05:01 with memory against hepatitis B (HB) vaccination. However, the effects of HLA-DPB1 on antibodies to hepatitis B surface antigen (anti-HBs) kinetics were not explored. We followed up a cohort of 1974 HB booster recipients and quantified their 1-month and 1-year post-booster anti-HBs titers. A total of 681 subjects were randomly selected and typed for HLA-DPB1. We found that male subjects, undetectable pre-booster titers, and 05:01 homozygotes led to significantly lower post-booster anti-HBs titers. The geometric means (95% confidence interval (CI)) of 1-month post-booster anti-HBs titers were 4.68 (2.69-8.12), 23.01 (14.96-35.40) and 50.06 (27.20-92.13) mIU ml(-1) for subjects carrying two, one and no HLA-DPB1 05:01 allele. The corresponding figures for 1-year post-booster anti-HBs titers were 1.26 (0.73-2.18), 4.72 (3.08-7.25) and 7.32 (3.75-13.56) mIU ml(-1). There were significant associations of post-booster anti-HBs titers with the number of HLA-DPB1 risk and protective alleles. Among booster responders, anti-HBs decay rates were significantly reduced in subjects who had detectable pre-booster anti-HBs titers and the HLA-DPB1 05:01 allele. Our results indicated that HLA-DPB1 influences the kinetics of anti-HBs. The long-term memory against hepatitis B surface antigen (HBsAg) and the residual serum titers of anti-HBs after HB vaccination may be influenced by different mechanisms as evidenced by their inverse trend of associations with the 05:01 allele.
authors.affiliation: Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
authors.forename: T-W
authors.initials: TW
authors.lastname: Wu
authors.affiliation: 1] Immunogenetics Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei City, Taiwan [2] Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Chu
authors.affiliation: Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
authors.forename: H-W Chang
authors.initials: HW
authors.lastname: Liao
authors.affiliation: Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
authors.forename: S-K
authors.initials: SK
authors.lastname: Lin
authors.affiliation: Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
authors.forename: T-Y
authors.initials: TY
authors.lastname: Ho
authors.affiliation: Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, New Taipei City, Taiwan.
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.affiliation: 1] Department of Gastroenterology, Buddhist Tzu Chi General Hospital Taipei Branch, New Taipei City, Taiwan [2] Department of Internal Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: H H
authors.initials: HH
authors.lastname: Lin
authors.affiliation: 1] Department of Medicine, Mackay Medical College, New Taipei City, Taiwan [2] Institute of Public Health, Tzu Chi University, Hualien, Taiwan [3] Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
authors.forename: L-Y
authors.initials: LY
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D059868:HLA-DP beta-Chains / Q000235:genetics*; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D007223:Infant; D007700:Kinetics; D016014:Linear Models; D008297:Male
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines