title: A preliminary study on the effects of acute ethanol ingestion on default mode network and temporal fractal properties of the brain.
abstract: OBJECTIVE
  To study the effect of acute alcohol intoxication on the functional connectivity of the default mode network (DMN) and temporal fractal properties of the healthy adult brain.
  
  
  METHODS
  Eleven healthy male volunteers were asked to drink 0.59 g/kg of ethanol. Resting state blood oxygen level dependent (rsBOLD) MRI scans were obtained before consumption, 60 min post-consumption and 90 min post-consumption. Before each rsBOLD scan, pointed-resolved spectroscopy (PRESS) (1)H-MRS (magnetic resonance spectroscopy) scans were acquired to measure ethanol levels in the right basal ganglia.
  
  
  RESULTS
  Significant changes in DMN connectivity were found following alcohol consumption (p < 0.01). Both increased and decreased regional connectivity were found after 60 min, whereas mostly decreased connectivity was found after 90 min. The fractal behaviour of the rsBOLD signal, which is believed to help reveal complexity of small-scale neuronal circuitry, became more ordered after both 60 and 90 min of alcohol consumption (p < 0.01).
  
  
  CONCLUSIONS
  The DMN has been linked to personal identity and social behavior. As such, our preliminary findings may provide insight into the neuro-functional underpinnings of the cognitive and behavioral changes observed during acute alcohol intoxication. The reduced fractal dimension implies a change in function of small-scale neural networks towards less complex signaling.
authors.affiliation: School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Weber
authors.forename: Noam
authors.initials: N
authors.lastname: Soreni
authors.forename: Michael D
authors.initials: MD
authors.lastname: Noseworthy
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001784:Blood Gas Analysis; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D000431:Ethanol / Q000506:poisoning*; D017709:Fractals; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D010100:Oxygen / Q000097:blood*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000431:Ethanol; D010100:Oxygen