title: [Cognitive adverse effects of anticholinergic medication for overactive bladder in PD/DLB].
abstract: Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturition-inhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients.
authors.affiliation: Neurology, Sakura Medical Center, Toho University.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sakakibara
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000188:drug therapy / Q000209:etiology; D001479:Basal Ganglia / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000378:metabolism; D018680:Cholinergic Antagonists / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D003072:Cognition Disorders / Q000139:chemically induced*; D059290:Dopaminergic Neurons / Q000502:physiology; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications; D010300:Parkinson Disease / Q000150:complications; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology; D014554:Urination
chemical_list: D018680:Cholinergic Antagonists