title: Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos-Rh complex.
abstract: Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos-Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.
authors.affiliation: School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, P.R. China. wpchen@fmmu.edu.cn.
authors.forename: Quanjun
authors.initials: Q
authors.lastname: Wang
authors.forename: Xueying
authors.initials: X
authors.lastname: Liu
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Huifang
authors.initials: H
authors.lastname: Nie
authors.forename: Shengyong
authors.initials: S
authors.lastname: Zhang
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D006865:Hydrogenation; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000935:Antifungal Agents; D056831:Coordination Complexes; D009025:Morpholines; C038974:amorolfine; D012238:Rhodium