title: Isolation of Soil Microorganisms Having Antibacterial Activity and Antimigratory Effects on Sphingosylphosphorylcholine-induced Migration of PANC-1 Cells.
abstract: To obtain soil microorganisms producing antimigratory activity which is important in controlling the metastasis of cancer cells, more than three hundreds of soil microbes were isolated from sixteen soil sources including Namsan mountain and designated as DGU1001-10338. At first, their antibiotic activities were examined by paper-disc method. More than 40 soil microbes produced compounds with antibiotic activity. Then, antimigratory activities of selected soil microorganisms were examined in a sphingosylphosphorylcholine-induced migration assay in PANC-1 cells. Six of 42 soil microorganisms having antibacterial activity also had more than 45% inhibitory activity on migration of PANC-1 cells. These results suggested that selected soil microorganisms were a useful starting point to find compounds for controlling metastasis of cancer cells.
authors.affiliation: College of Pharmacy, Dongguk University, Seoul 100-715, Korea.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Kang
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Park
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kim
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Lee
keywords: Antibiotics; PANC-1 cells; Paper disc method; Soil microorganisms; Sphingosylphosphorylcholine (SPC)