title: Multidisciplinary approach to the treatment of obese adolescents: effects on cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance.
abstract: The prevention of obesity and health concerns related to body fat is a major challenge worldwide. The aim of this study was to investigate the role of a medically supervised, multidisciplinary approach, on reduction in the prevalence of obesity related comorbidities, inflammatory profile, and neuroendocrine regulation of energy balance in a sample of obese adolescents. A total of 97 postpuberty obese adolescents were enrolled in this study. Body composition, neuropeptides, and adipokines were analysed. The metabolic syndrome was defined by the International Diabetes Federation (IDF). The abdominal ultrasonography was performed to measure visceral, subcutaneous fat and hepatic steatosis. All measures were performed at baseline and after one year of therapy. The multidisciplinary management promoted the control of obesity reducing body fat mass. The prevalence of metabolic syndrome, asthma, nonalcoholic fatty liver disease (NAFLD), binge eating, and hyperleptinemia was reduced. An improvement in the inflammatory profile was demonstrated by an increase in anti-inflammatory adiponectin and reduction in proinflammatory adipokines, plasminogen activator inhibitor-1, interleukin-6 concentrations, and in the Lep/Adipo ratio. Moreover, a reduction in the AgRP and an increase in the alfa-MSH were noted. The multidisciplinary approach not only reduced obesity but also is efficacious in cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance.
authors.affiliation: Department of Biosciences, Universidade Federal de São Paulo (UNIFESP), Rua Silva Jardim, 136 Térreo, Vila Mathias, 11015-020 Santos, SP, Brazil ; Post-Graduate Program of Nutrition, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Marselhesa 630, Vila Clementino, 04020-060 São Paulo, SP, Brazil.
authors.forename: Ana Raimunda
authors.initials: AR
authors.lastname: Dâmaso
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.forename: Raquel Munhoz da Silveira
authors.initials: RM
authors.lastname: Campos
authors.forename: Flávia Campos
authors.initials: FC
authors.lastname: Corgosinho
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Siegfried
authors.forename: Danielle Arisa
authors.initials: DA
authors.lastname: Caranti
authors.forename: Deborah Cristina Landi
authors.initials: DC
authors.lastname: Masquio
authors.forename: June
authors.initials: J
authors.lastname: Carnier
authors.forename: Priscila de Lima
authors.initials: Pde L
authors.lastname: Sanches
authors.forename: Patrícia
authors.initials: P
authors.lastname: Leão da Silva
authors.forename: Cláudia Maria Oller
authors.initials: CM
authors.lastname: Nascimento
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.forename: Alexandre Dâmaso Aguilera
authors.initials: AD
authors.lastname: Dantas
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Lian
authors.initials: L
authors.lastname: Tock