title: The effective evaluation on symptoms and quality of life of chronic obstructive pulmonary disease patients treated by comprehensive therapy based on traditional Chinese medicine patterns.
abstract: OBJECTIVE
  To evaluate the efficacy of comprehensive interventions based on the three TCM patterns on symptoms and quality of life of COPD patients.
  
  
  METHODS
  An open-label, randomized, controlled trial.
  
  
  METHODS
  Four hospitals in China.
  
  
  METHODS
  352 patients were randomly divided into two groups. Patients in the trial group were given conventional Western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules and Yi-Qi Zi-Shen granules respectively; patients in the control group were given conventional Western medicine. Data collection was performed at baseline, in the 3rd and 6th month during the treatment period, and the 12th month during the follow-up period.
  
  
  RESULTS
  Symptoms, including cough, sputum, pant, chest tightness, short of breath, lassitude, cyanosis and symptom total score; quality of life, measured by the WHOQOL-BREF questionnaire and adult COPD quality of life questionnaire (COPD-QOL).
  
  
  RESULTS
  Of the 352 patients, 306 fully completed the study. After treatment and follow-up, there were significant differences between two groups in the following: cough, sputum, pant, chest tightness, shortness of breath, lassitude score and symptom total score (P<.05); physical, psychological, social and environment domain (P<.05) of the WHOQOL-BREF; daily living ability, social activity, depression symptoms and anxiety symptoms domain (P<.05) of the COPD-QOL. There were no differences between two groups in cyanosis and adverse events.
  
  
  CONCLUSIONS
  Based on the TCM patterns, Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules and Yi-Qi Zi-Shen granules have beneficial effects on symptoms and quality of life of COPD patients.
authors.affiliation: Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, No. 19 Renmin Road, Zhengzhou, PR China; The Geriatric Department, Henan University of Traditional Chinese Medicine, Longzihu University Town, Zhengdong New District, Zhengzhou, PR China. Electronic address: li_js8@163.com.
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Su-yun
authors.initials: SY
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.forename: Xue-qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Ming-hang
authors.initials: MH
authors.lastname: Wang
authors.forename: Zi-kai
authors.initials: ZK
authors.lastname: Sun
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Ma
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Jia
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Zhang
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Xu
authors.forename: Cong-xia
authors.initials: CX
authors.lastname: Hou
mesh_terms: D000368:Aged; D002681:China; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D018709:Statistics, Nonparametric
chemical_list: C574914:Bu-Fei-Yi-Shen; D004365:Drugs, Chinese Herbal
keywords: Bu-Fei Jian-Pi granules; Bu-Fei Yi-Shen granules; COPD; Chronic obstructive pulmonary disease; FAS; FEV1; FEV1 percentage of predicted value; FEV1%; FVC; PPS; QOL; Quality of life; TCM; Tradition Chinese medicine pattern; Yi-Qi Zi-Shen granules; chronic obstructive pulmonary disease; forced expiratory volume in one second; forced vital capacity; full analysis set; per-protocol analysis set; quality of life; traditional Chinese medicine