title: A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair.
abstract: Mediator of DNA-damage checkpoint 1 (MDMDC1) has a central role in repair of DNA double-strand breaks (DSBs) by both homologous recombination and nonhomologous end joining, and its function is regulated by post-translational phosphorylation, ubiquitylation and sumoylation. In this issue, a new study by Watanabe et al. reveals that methylation of MDMDC1 is also critical for its function in DSB repair and specifically affects repair through BRCA1-dependent homologous recombination.
authors.affiliation: Johns Hopkins University, Bloomberg School of Public Health, Department of Biochemistry and Molecular Biology, Baltimore, Maryland, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Matunis
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D019313:BRCA1 Protein / Q000502:physiology*; D018797:Cell Cycle Proteins; D053960:DNA Breaks; D004268:DNA-Binding Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C413163:MDC1 protein, human; D009687:Nuclear Proteins; C486521:RNF8 protein, human; D015534:Trans-Activators; C520448:JMJD1C protein, human; D056484:Jumonji Domain-Containing Histone Demethylases; D010089:Oxidoreductases, N-Demethylating; D044767:Ubiquitin-Protein Ligases