title: Oxidative stress and aging: correlation with clinical parameters.
abstract: OBJECTIVE
  The free radical theory of aging has been receiving a lot of attention in the past years. The aim of this study was to examine the correlation between oxidative damage, antioxidant enzyme activities and plasma antioxidant potential with clinical parameters in elderly people.
  
  
  METHODS
  Elderly subjects over 80 years old were included in the study. Clinical data were collected based on the Cumulative Illness Rating Scale (n = 132). In addition, blood samples were collected to determine biochemical and oxidative stress.
  
  
  RESULTS
  The results showed that the mean age of the participants was 85.1 ± 4.0 years old. Diabetic patients presented higher plasma protein carbonyl levels when compared with non-diabetic, and plasma levels of thiobarbituric acid-reactive substances were correlated to serum triglyceride and LDL fraction. In contrast, a lower plasma total antioxidant capacity presented a relation with the presence of diabetes and arterial hypertension. In addition, healthy elderly subjects presented a higher plasma total antioxidant capacity.
  
  
  CONCLUSIONS
  Thus, it seemed that plasma antioxidant potential is a better predictor of successful aging in the elderly than oxidative damage parameters or plasma antioxidant enzyme activities.
authors.affiliation: Laboratório de Fisiopatologia Experimental and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Ana Carla
authors.initials: AC
authors.lastname: da Cruz
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Claudia Cipriano Vidal
authors.initials: CC
authors.lastname: Heluany
authors.forename: Francieli
authors.initials: F
authors.lastname: Vuolo
authors.forename: Samantha Pereira
authors.initials: SP
authors.lastname: Miguel
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000975:Antioxidants