title: Agonistic approach of omega-3, omega-6 and its metabolites with BDNF: An in-silico study.
abstract: Brain derived neurotrophic factor (BDNF) is a member of neurotrophic family of growth factors, mainly found in the hippocampus and cerebral cortex of brain. Studies have shown that there is a link between BDNF and cognitive dysfunction, as well as there is a relationship between the PUFAs intake and their effect on BDNF production. Intake of PUFAs, mainly omega-3 and omega-6 has show increase in production of BDNF in brain. In our study we performed docking studies on PUFAs and their metabolites with BDNF using MVD (Molegro Virtual Docker), this has shown that the metabolites of the PUFAs mainly LXA_4, NPD1, HDHA have shown more binding affinity towards BDNF. These metabolites of PUFAs are responsible for modulation of BDNF activity.
authors.affiliation: C R RAO Advanced Institute of Mathematics Statistics and Computer Science, University of Hyderabad campus, Gachibowli, Hyderabad-500046.
authors.forename: Yadla Phani
authors.initials: YP
authors.lastname: Kumar
authors.forename: G Sri Shanmukha
authors.initials: GS
authors.lastname: Srinivas
authors.forename: Yadu Mitravinda
authors.initials: YM
authors.lastname: E
authors.forename: Lalitha
authors.initials: L
authors.lastname: Malla
authors.forename: Allam Appa
authors.initials: AA
authors.lastname: Rao
keywords: BDNF; Cognitive dysfunction; Escore; Evolutionary algorithm; HDHA; LXA_4; MVD; NPD1; PUFA; cavity detection algorithm