title: HIV antibody characterization as a method to quantify reservoir size during curative interventions.
abstract: Quantitative humoral profiling of recent samples from a human immunodeficiency virus (HIV)-infected adult who was cured following a delta32/delta32 CCR5 stem cell transplant in 2007 revealed no antibodies against p24, matrix, nucleocapsid, integrase, protease, and gp120, but low levels of antibodies against reverse transcriptase, tat, and gp41. Antibody levels to these HIV proteins persisted at high and stable levels in most noncontrollers, elite controllers, and antiretroviral-treated subjects, but a rare subset of controllers had low levels of antibodies against matrix, reverse transcriptase, integrase, and/or protease. Comprehensive HIV antibody profiles may prove useful for monitoring curative interventions.
authors.affiliation: Clinical Dental Research Core, National Institute of Dental and Craniofacial Research.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Burbelo
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bayat
authors.forename: Craig S
authors.initials: CS
authors.lastname: Rhodes
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hoh
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Martin
authors.forename: Rémi
authors.initials: R
authors.lastname: Fromentin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chomont
authors.forename: Gero
authors.initials: G
authors.lastname: Hütter
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
mesh_terms: D000328:Adult; D004279:DNA, Viral; D015967:Gene Expression Regulation, Viral; D015483:HIV Antibodies / Q000097:blood* / Q000276:immunology; D015658:HIV Infections / Q000628:therapy*; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D033581:Stem Cell Transplantation
chemical_list: D004279:DNA, Viral; D015483:HIV Antibodies; D054298:Human Immunodeficiency Virus Proteins
keywords: HIV-1; HIV-1 persistence; antibodies; elite controllers; serology; viral reservoirs