title: Intramolecular Fischer indole synthesis in combination with alkyne hydroarylation: synthesis of tetracyclic chromeno-indoles.
abstract: Aryl hydrazides bearing a carbonyl function connected through an alkyne tether underwent an intramolecular Fischer indolization and alkyne hydroarylation in a tandem fashion to afford novel tetracyclic chromeno-indoles. The accompanying isomerization of the 2H-chromene double bond can be avoided by stopping the tandem process at the indolophane stage and conducting the alkyne-hydroarylation reaction separately in the absence of a proton source.
authors.affiliation: Department of Chemistry, Hanyang University , Seoul 131-791, Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Park
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Cheon-Gyu
authors.initials: CG
authors.lastname: Cho
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D001578:Benzopyrans; D007211:Indoles