title: [Phagocytosis and cytokinesis: highlights on common themes and differences].
abstract: Eukaryotic cells use and adapt common molecular machineries. Recent findings have highlighted that actin polymerization, contractile activity and membrane remodelling with exocytosis of internal compartments are required both for successful phagocytosis, the internalization of particulate material and for cytokinesis, the last step of cell division. Phagocytosis is induced by the triggering of specific cell surface receptors, which leads to membrane deformation, pseudopod extension and contraction to engulf particles. Cytokinesis relies on intense contractile activity and eventually leads to the physical scission of sister cells. In this review, shared features of signalling, cytoskeletal reorganization and vesicular trafficking used in both phagocytosis and cytokinesis are described, and questions that remain open in these dynamic areas of research are also highlighted.
authors.affiliation: Inserm U1016, CNRS UMR 8104, université Paris Descartes et Sorbonne Paris-Cité, Institut Cochin, équipe phagocytose et invasion bactérienne, 22, rue Méchain, 75014, Paris, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Deschamps
authors.forename: Arnaud
authors.initials: A
authors.lastname: Echard
authors.forename: Florence
authors.initials: F
authors.lastname: Niedergang
mesh_terms: D000199:Actins / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D005057:Eukaryotic Cells / Q000502:physiology; D005089:Exocytosis; D020558:GTP Phosphohydrolases / Q000502:physiology; D008563:Membrane Lipids / Q000502:physiology; D008870:Microtubules; D010587:Phagocytosis / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
chemical_list: D000199:Actins; D008563:Membrane Lipids; D011956:Receptors, Cell Surface; D020558:GTP Phosphohydrolases