title: Multicomponent synthesis of unsymmetrical unsaturated N-heterocyclic carbene precursors and their related transition-metal complexes.
abstract: A low-cost, modular, and easily scalable multicomponent procedure affording access in good yields and excellent selectivity (up to 93%) to a wide range of (a)chiral unsymmetrical 1-aryl-3-cycloalkyl-imidazolium salts is disclosed. Electronic and steric properties of the corresponding unsymmetrical unsaturated N-heterocyclic carbene (U2-NHC) ligands were evaluated and evidenced strong electron donor ability, high steric discrimination, and modular steric demand.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7 (France).
authors.forename: Pierre
authors.initials: P
authors.lastname: Queval
authors.forename: Claire
authors.initials: C
authors.lastname: Jahier
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rouen
authors.forename: Isabelle
authors.initials: I
authors.lastname: Artur
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Legeay
authors.forename: Laura
authors.initials: L
authors.lastname: Falivene
authors.forename: Loic
authors.initials: L
authors.lastname: Toupet
authors.forename: Christophe
authors.initials: C
authors.lastname: Crévisy
authors.forename: Luigi
authors.initials: L
authors.lastname: Cavallo
authors.forename: Olivier
authors.initials: O
authors.lastname: Baslé
authors.forename: Marc
authors.initials: M
authors.lastname: Mauduit
keywords: N-heterocyclic carbenes; chirality; ligand design; multicomponent reactions; transition metals