title: The effects of hormone therapy on ischemia modified albumin and soluble CD40 ligand levels in obese surgical menopausal women.
abstract: OBJECTIVE
  To determine the effects of hormone therapy (HT) on ischemia modified albumin (IMA) and soluble (s)CD40 ligand in obese surgical menopausal women.
  
  
  METHODS
  A total of 52 obese surgical menopausal women with a body mass index (BMI) > 30 kg/m2 were admitted to the study. Twenty-seven women received estradiol hemihydrate two mg and 25 did not receive any menopausal therapy. At baseline and after three and six months of treatment, IMA and sCD40 ligand levels were measured.
  
  
  RESULTS
  There were no significant differences among the groups for any variables at baseline. No difference in change in the serum sCD40L levels was found in obese surgical menopausal women after three and six months of HT. Serum IMA levels were statistically lowered in obese women with HT after six months of treatment.
  
  
  CONCLUSIONS
  HT may have a beneficial reduction in IMA levels in obese surgical menopausal women.
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynecology, Trabzon, Turkey. drmaosmanaga@gmail.com
authors.forename: M A
authors.initials: MA
authors.lastname: Osmanağaoğlu
authors.forename: S C
authors.initials: SC
authors.lastname: Karahan
authors.forename: T
authors.initials: T
authors.lastname: Aran
authors.forename: S
authors.initials: S
authors.lastname: Güven
authors.forename: A
authors.initials: A
authors.lastname: Cora
authors.forename: M
authors.initials: M
authors.lastname: Kopuz
authors.forename: H
authors.initials: H
authors.lastname: Bozkaya
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D023201:CD40 Ligand / Q000097:blood*; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use; D004967:Estrogens / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009765:Obesity / Q000097:blood*; D012709:Serum Albumin / Q000187:drug effects*; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D004967:Estrogens; D012709:Serum Albumin; C561522:ischemia-modified albumin; D023201:CD40 Ligand; D004958:Estradiol; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human