title: Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes.
abstract: We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC.
authors.affiliation: UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Zach
authors.initials: Z
authors.lastname: Nadler
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Nevins
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Larry
authors.initials: L
authors.lastname: Kagemann
authors.forename: Ian A
authors.initials: IA
authors.lastname: Sigal
authors.forename: R Daniel
authors.initials: RD
authors.lastname: Ferguson
authors.forename: Daniel X
authors.initials: DX
authors.lastname: Hammer
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Grulkowski
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Liu
authors.forename: Martin F
authors.initials: MF
authors.lastname: Kraus
authors.forename: Chen D
authors.initials: CD
authors.lastname: Lu
authors.forename: Joachim
authors.initials: J
authors.lastname: Hornegger
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
keywords: (100.2000) Digital image processing; (110.4500) Optical coherence tomography; (170.1610) Clinical applications; (170.4470) Ophthalmology; (330.4460) Ophthalmic optics and devices