title: Bilateral parotid gland enlargement and palpable nephromegaly in infant acute lymphoblastic leukemia: case report and review of the literature.
abstract: Acute lymphoblastic leukemia (ALL) in infants below 1 year of age accounts for 2.5% to 5% of childhood ALL. Most children with ALL present with fever, bruising, mucosal bleeding, bone pain, pallor, hepatosplenomegaly, and lymphadenopathy. Common sites of extramedullary involvement at diagnosis include liver, spleen, lymph nodes, brain, and testes. Nephromegaly has also been reported. We present a novel case of bilateral parotid enlargement along with bilateral palpable nephromegaly in a patient with newly diagnosed infant ALL. This unique presentation highlights the importance of considering ALL in the differential diagnosis of parotid enlargement especially when associated with abnormal blood counts.
authors.affiliation: Departments of *Pediatrics, Division of Pediatric Hematology-Oncology †Radiology, NYU Langone Medical Center, New York, NY.
authors.forename: Aniket
authors.initials: A
authors.lastname: Saha
authors.forename: Smita
authors.initials: S
authors.lastname: Dandekar
authors.forename: Sarah
authors.initials: S
authors.lastname: Milla
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Roman
authors.forename: Teena
authors.initials: T
authors.lastname: Bhatla
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis*; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis*; D008206:Lymphatic Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D010306:Parotid Gland / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D011379:Prognosis; D012196:Review Literature as Topic