title: MRI in necrotizing fasciitis of the extremities.
abstract: Necrotizing fasciitis is a life-threatening soft-tissue infection of bacterial origin, which involves mainly the deep fascia. Early recognition of this condition may be hampered by the uncommon nature of the disease and non-specificity of initial clinical signs and symptoms in less fulminant cases, making the role of imaging important. MRI is the most useful imaging modality in the diagnosis of necrotizing fasciitis. The presence of thick (>3 mm) hyperintense signal in the deep fascia (particularly intermuscular fascia) on fat-suppressed T2 weighted or short tau inversion-recovery images is an important marker for necrotizing fasciitis. Contrast enhancement of the thickened necrotic fascia can be variable, with a mixed-pattern of enhancement being more commonly encountered. Involvement of multiple musculofascial compartments increases the likelihood of necrotizing fasciitis. It is important to remember that T2-hyperintense signal in the deep fascia is not specific to necrotizing fasciitis and can also be seen in cases such as non-infective inflammatory fasciitis or muscle tear. In this pictorial essay, we aim to review the MRI findings in necrotizing fasciitis, discuss its limitations and pitfalls and identify differentiating features from non-necrotizing soft-tissue infections, such as cellulitis and infective myositis/pyomyositis, conditions which may clinically mimic necrotizing fasciitis.
authors.affiliation: Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore, Singapore.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Ali
authors.forename: S
authors.initials: S
authors.lastname: Srinivasan
authors.forename: W C G
authors.initials: WC
authors.lastname: Peh
mesh_terms: D002481:Cellulitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005121:Extremities; D005205:Fascia / Q000473:pathology*; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018461:Soft Tissue Infections / Q000175:diagnosis