title: Hydroethanolic extract of Pyrostegia venusta (Ker Gawl.) Miers flowers improves inflammatory and metabolic dysfunction induced by high-refined carbohydrate diet.
abstract: BACKGROUND
  Pyrostegia venusta is used in traditional Brazilian medicine as a general tonic to treat any inflammatory disease. Several studies have demonstrated that medicinal plants constitute a therapeutic approach for the treatment of obesity-related metabolic and inflammatory disarrangement. Accordingly, we investigated the effects of hydroethanolic extract of Pyrostegia venusta flowers (PvHE) supplementation for the treatment of inflammatory and metabolic dysfunction induced by high-refined-carbohydrate (HC) diet.
  
  
  METHODS
  The BALB/c mice were fed chow or HC diet for 8 weeks. Part of these animals was fed with HC diet supplemented with PvHE on the 9th week until the 12th week. At the end of the dietary intervention, animals were sacrificed.
  
  
  RESULTS
  We observed that PvHE decreased adiposity and adipocyte area; improved glucose intolerance; reduced serum triacylglycerol levels and systemic inflammatory cells; and also reduced some inflammatory mediators levels in adipose tissue and liver.
  
  
  CONCLUSIONS
  The results showed that PvHE has beneficial effects and may treat inflammatory and metabolic dysfunction induced by HC diet, that are associated to a negative modulation of the inflammatory process at systemic and local levels.
authors.affiliation: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Clarice de Carvalho
authors.initials: Cde C
authors.lastname: Veloso
authors.affiliation: Imunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil; Department of Nutrition, Nursing School, UFMG, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Marina Chaves
authors.initials: MC
authors.lastname: de Oliveira
authors.affiliation: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Cristina da Costa
authors.initials: Cda C
authors.lastname: Oliveira
authors.affiliation: Department of Chemistry, Institute of Exact Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Vanessa Gregório
authors.initials: VG
authors.lastname: Rodrigues
authors.affiliation: Department of Physiological Sciences, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Giusti-Paiva
authors.affiliation: Imunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.affiliation: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Igor Dimitri
authors.initials: ID
authors.lastname: Duarte
authors.affiliation: Imunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil; Department of Nutrition, Nursing School, UFMG, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Adaliene Versiani Matos
authors.initials: AV
authors.lastname: Ferreira
authors.affiliation: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. Electronic address: acp@icb.ufmg.br.
authors.forename: Andrea de Castro
authors.initials: Ade C
authors.lastname: Perez
mesh_terms: D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005951:Glucose Tolerance Test; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004040:Dietary Carbohydrates; D010936:Plant Extracts
keywords: High-refined-carbohydrate diet; Inflammation; Metabolism; Obesity; Pyrostegia venusta