title: Physical exercise interventions for improving performance-based measures of physical function in community-dwelling, frail older adults: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To conduct a systematic review to determine the efficacy of exercise-based interventions on improving performance-based measures of physical function and markers of physical frailty in community-dwelling, frail older people.
  
  
  METHODS
  Comprehensive bibliographic searches in MEDLINE, the Cochrane Library, PEDro, and CINAHL databases were conducted (April 2013).
  
  
  METHODS
  Randomized controlled trials of community-dwelling older adults, defined as frail according to physical function and physical difficulties in activities of daily living (ADL). Included trials had to compare an exercise intervention with a control or another exercise intervention, and assess performance-based measures of physical function such as mobility and gait, or disability in ADL.
  
  
  METHODS
  Two review authors independently screened the search results and performed data extraction and risk of bias assessment. Nineteen trials were included, 12 of them comparing exercise with an inactive control. Most exercise programs were multicomponent.
  
  
  RESULTS
  Meta-analysis was performed for the comparison of exercise versus control with the inverse variance method under the random-effects models. When compared with control interventions, exercise was shown to improve normal gait speed (mean difference [MD]=.07m/s; 95% confidence interval [CI], .04-.09), fast gait speed (MD=.08m/s; 95% CI, .02-.14), and the Short Physical Performance Battery (MD=2.18; 95% CI, 1.56-2.80). Results are inconclusive for endurance outcomes, and no consistent effect was observed on balance and the ADL functional mobility. The evidence comparing different modalities of exercise is scarce and heterogeneous.
  
  
  CONCLUSIONS
  Exercise has some benefits in frail older people, although uncertainty still exists with regard to which exercise characteristics (type, frequency, duration) are most effective.
authors.affiliation: Department of Physical Activity and Sport Sciences, FPCEE Blanquerna, Universitat Ramon Llull, Barcelona, Spain; Department of Physical Therapy, FCS Blanquerna, Universitat Ramon Llull, Barcelona, Spain. Electronic address: mariagg@blanquerna.url.edu.
authors.forename: Maria
authors.initials: M
authors.lastname: Giné-Garriga
authors.affiliation: Institute on Aging, Universitat Autònoma de Barcelona, Barcelona, Spain; Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Roqué-Fíguls
authors.affiliation: Institute on Aging, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Coll-Planas
authors.affiliation: Department of Physical Therapy, FCS Blanquerna, Universitat Ramon Llull, Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Sitjà-Rabert
authors.affiliation: Institute on Aging, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Salvà
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D015444:Exercise; D016330:Frail Elderly; D005684:Gait / Q000502:physiology; D006801:Humans; D051346:Mobility Limitation; D004856:Postural Balance / Q000502:physiology
keywords: Exercise; Frail elderly; Meta-analysis; Rehabilitation; Review, systematic