title: Intralesional treatment for keloids and hypertrophic scars: a review.
abstract: BACKGROUND
  Although differing in clinical presentation and prognosis, keloids and hypertrophic scars are generally characterized by abnormally proliferative scar tissue and are extremely debilitating. Several intralesional therapies have been studied in attempts to find a universally safe and effective modality, of which there are currently none.
  
  
  OBJECTIVE
  To provide a comprehensive review of current intralesional treatment modalities for keloids and hypertrophic scars.
  
  
  METHODS
  A PubMed search was performed for literature pertaining to intralesional treatment modalities for keloids and hypertrophic scars. References from retrieved articles were also considered for review.
  
  
  CONCLUSIONS
  Many intralesional therapies for keloids and hypertrophic scars are currently available to physicians and patients. Mechanisms of action and side effect profiles vary between these agents, and new approaches to keloids and hypertrophic scars are frequently being explored. Randomized controlled trials are needed to assess these new and promising modalities fully.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Ledon
authors.forename: Jessica
authors.initials: J
authors.lastname: Savas
authors.forename: Katlein
authors.initials: K
authors.lastname: Franca
authors.forename: Anna
authors.initials: A
authors.lastname: Chacon
authors.forename: Keyvan
authors.initials: K
authors.lastname: Nouri
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D017439:Cicatrix, Hypertrophic / Q000628:therapy*; D003131:Combined Modality Therapy; D017679:Cryotherapy / Q000379:methods; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000628:therapy*; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000903:Antibiotics, Antineoplastic; D000963:Antimetabolites; D002121:Calcium Channel Blockers; D001761:Bleomycin; D014700:Verapamil; D005472:Fluorouracil