title: Amine-catalyzed direct photoarylation of unactivated arenes.
abstract: Constructing biaryls through direct aromatic C-H functionalization of unactivated arenes has become a popular topic in organic chemistry. Many efficient methods have been developed. In this Communication, a direct arylation of unactivated arenes with a broad range of aryl iodides is reported. This reaction proceeds through a new type of amine-catalyzed single electron transfer initiated radical coupling procedure to form biaryls in high yields under UV irradiation at room temperature. Only 20 mol% of TMEDA is used as the catalyst. No other additives are required for this transformation, thus avoiding the use of toxic transition metal catalysts, strong bases, or large amounts of other organic additives. This greener protocol provides a new strategy to achieve direct aromatic C-H functionalization and offers a new example of cost-effective and environmentally benign access to biaryls.
authors.affiliation: Institute of Chemistry & Biological Engineering, Changsha University of Science and Technology, Changsha, 410114 (P. R. China). xingliangzheng@163.com.
authors.forename: Xingliang
authors.initials: X
authors.lastname: Zheng
authors.forename: Luo
authors.initials: L
authors.lastname: Yang
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Du
authors.forename: Aishun
authors.initials: A
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
mesh_terms: D000588:Amines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D000588:Amines; D001555:Benzene Derivatives; D005609:Free Radicals; D009942:Organometallic Compounds; C450681:phenyllithium; D002244:Carbon; D006859:Hydrogen
keywords: CH functionalization; arylation; biaryls; photochemistry; radical reactions