title: Brain-derived neurotrophic factor Val66Met polymorphism and cognitive function in persons with cardiovascular disease.
abstract: OBJECTIVE
  Cognitive impairment is common among persons with cardiovascular disease (CVD), and several potential aetiological mechanisms have been described, including contributions of genetic markers such as variations in the brain-derived neurotrophic (BDNF) gene. This current study examined the associations of BDNF genotype with cognitive function among individuals with CVD.
  
  
  METHODS
  This study included 110 participants with CVD who completed a comprehensive neuropsychological battery that assessed global cognitive function, attention/executive function, memory, language, and visuospatial abilities. All participants also underwent blood draw to provide a DNA sample that was used to determine BDNF genotype. Carriers of either one or two copies of the methionine allele of BDNF were categorized into one group (n = 33); non-carriers were categorized into a second group (n = 77).
  
  
  RESULTS
  After adjustment for demographic and medical characteristics, hierarchical regression analyses revealed persons with one or more methionine alleles displayed better performance than valine/valine individuals for attention/executive function (β = 0.22, P = 0.047) and memory (β = 0.25, P = 0.03), as well as a trend for language (β = 0.19, P = 0.08) and visuospatial abilities (β = 0.21, P = 0.06).
  
  
  CONCLUSIONS
  BDNF Val66Met had little impact on cognitive functioning in a sample of older adults with CVD, and significant findings contradicted that predicted by past work. Future work is much needed to clarify the mechanisms of these findings, particularly studies examining both circulating BDNF levels and genetic variation in the BDNF gene and cognitive function over time.
authors.affiliation: Department of Psychology, Kent State University, Kent, Ohio, USA.
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Szabo
authors.forename: Michael L
authors.initials: ML
authors.lastname: Alosco
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Miller
authors.forename: John E
authors.initials: JE
authors.lastname: McGeary
authors.forename: Athena
authors.initials: A
authors.lastname: Poppas
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Cohen
authors.forename: John
authors.initials: J
authors.lastname: Gunstad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001288:Attention; D001921:Brain / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications* / Q000235:genetics*; D003071:Cognition; D003072:Cognition Disorders / Q000097:blood / Q000150:complications* / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015577:Geriatric Assessment / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008568:Memory; D008715:Methionine / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic / Q000235:genetics*; D014633:Valine / Q000097:blood / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005819:Genetic Markers; D008715:Methionine; D014633:Valine
keywords: BDNF; Met allele; cardiovascular disease; cognitive function; genetics