title: Association of single nucleotide polymorphism of GHSR and TGFB2 genes with growth and body composition traits in sire and dam lines of a broiler chicken.
abstract: Growth hormone secretagogue receptor (GHSR) modulates many physiological processes by binding to its ligand, as well as transforming growth factor-beta 2 (TGFB2) regulates cell growth and development in animals and, therefore, are candidate genes for performance in chickens. In the current study, single nucleotide polymorphisms of GHSR C3286 > T and TGFB2 T(-640) > C were genotyped in sire and dam lines of a broiler chicken to evaluate the association with the growth and body composition traits. Least squares means analysis showed that the GHSR C3286 > T SNP was significantly (P < 0.01) associated with growth (DFI and ADG) and body composition traits (AFW and %AFW). In addition, the TGFB2 T(-640) > C SNP was associated with ADG (P < 0.05) and DFI and body composition traits (DW, LBW, BAKWT, %BMW, %HNDWT and %CW) (P < 0.01). Significant associations of the single nucleotide polymorphisms (SNPs) on the traits reported in the present study might be the distinct usage of codons in avian, or relating to an enhancer element and modulating the expression of the gene in chicken. The data indicated that these SNPs could be valuable genetic elements for selection of chickens for better performance in the population.
authors.affiliation: a Department of Animal Science, Faculty of Agriculture , Tarbiat Modares University , Tehran , Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Darzi Niarami
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Masoudi
authors.forename: Rasoul
authors.initials: R
authors.lastname: Vaez Torshizi
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002645:Chickens / Q000235:genetics* / Q000254:growth & development*; D005260:Female; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054440:Receptors, Ghrelin / Q000235:genetics*; D053781:Transforming Growth Factor beta2 / Q000235:genetics*
chemical_list: D054440:Receptors, Ghrelin; D053781:Transforming Growth Factor beta2