title: Recombinant human bone morphogenetic protein-2 confined by an imperforate titanium shell over high-profile dental implants in rabbit tibiae: a pilot bone augmentation study.
abstract: OBJECTIVE
  To evaluate the use of a nonperforated titanium occlusive device over a bone morphogenetic protein-2 in an absorbable collagen sponge (BMP-2/ACS) in grafting the bone around high-profile (ie, supracrestal) dental implants in rabbit tibiae.
  
  
  METHODS
  Eight New Zealand white rabbits were used for the experiment. Two implants were placed in the right tibia of each rabbit, with 4 mm of each implant placed supracrestally ("high-profile" placement) in four groups of two rabbits each: control, titanium shell only, titanium shell over buffered collagen, and titanium shell over BMP-2/ACS. The animals were sacrificed after 3 or 6 weeks. Calcified and nondecalcified histologic preparation was carried out to evaluate bone formation and degree of osseointegration.
  
  
  RESULTS
  Three of the eight animals developed tibial fractures. The two BMP-2 test animal tibiae remained intact, with the 3-week specimen showing very little bone formation inside or outside of the titanium chamber and the 6-week specimen showing bone mostly outside of the chamber.
  
  
  CONCLUSIONS
  The placement of BMP-2 beneath an occlusive nonperforated titanium shell next to a high-profile implant did not result in significant bone formation. .
authors.forename: Nardy
authors.initials: N
authors.lastname: Casap
authors.forename: Zvi
authors.initials: Z
authors.lastname: Laster
authors.forename: Amir
authors.initials: A
authors.lastname: Laviv
authors.forename: Meir
authors.initials: M
authors.lastname: Debecco
authors.forename: Michael
authors.initials: M
authors.lastname: Alterman
authors.forename: Jared
authors.initials: J
authors.lastname: Cottam
authors.forename: Ole T
authors.initials: OT
authors.lastname: Jensen
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D008297:Male; D016348:Osseointegration; D010012:Osteogenesis; D010865:Pilot Projects; D011817:Rabbits; D011994:Recombinant Proteins / Q000627:therapeutic use; D013977:Tibia; D013978:Tibial Fractures / Q000209:etiology; D014025:Titanium; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
chemical_list: D055396:Bone Morphogenetic Protein 2; D015921:Dental Implants; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen; D014025:Titanium