title: Brain creatine depletion in vegetarians? A cross-sectional ¹H-magnetic resonance spectroscopy (¹H-MRS) study.
abstract: The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (¹H-MRS). Dietary Cr intake was assessed by 3 d food recalls. Vegetarians had lower dietary Cr intake than omnivores (0.03 (SD 0.01) v. 1.34 (SD 0.62) g/d, respectively; P=0.005). However, vegetarians and omnivores had comparable brain total Cr content (5.999 (SD 0.811) v. 5.917 (SD 0.665) IU, respectively; P=0.77). In conclusion, dietary Cr did not influence brain Cr content in healthy individuals, suggesting that in normal conditions brain is dependent on its own Cr synthesis.
authors.affiliation: Division of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Yazigi Solis
authors.affiliation: Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, Av. Prof. Mello de Moraes 65, Sao Paulo, SP 05508-030, Brazil.
authors.forename: Vítor
authors.initials: V
authors.lastname: de Salles Painelli
authors.affiliation: Division of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Giannini Artioli
authors.affiliation: Division of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Hamilton
authors.initials: H
authors.lastname: Roschel
authors.affiliation: LIM44, Division of Magnetic Resonance, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: Concepción Otaduy
authors.affiliation: Division of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001938:Brazil; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000008:administration & dosage / Q000172:deficiency / Q000378:metabolism*; D003430:Cross-Sectional Studies; D014676:Diet, Vegetarian / Q000009:adverse effects*; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009752:Nutritional Status; D015203:Reproducibility of Results
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline