title: Effect of zinc chelate and valnemulin for the treatment of swine dysentery in an experimental challenge study.
abstract: The aim of study was to determine the influence of zinc chelate, valnemulin and it's combination on Brachyspira hyodysenteriae shedding and morphological changes of colonic mucosa in an experimental model of swine dysentery (SD). The study was performed on pigs coming from a dysentery-free herd. Animals were inoculated by B. hyodysenteriae strain B204. When the clinical signs of SD and B. hyodysenteriae shedding developed, the pigs were divided into four treatment groups. The first group was treated with zinc chelate (250 ml/1000 L in water), second group was given valnemulin in feed at 75 ppm; the third group was given a combination of both and the fourth group was control. The results demonstrated therapeutic effect of valnemulin in pigs with serious SD and did not show therapeutic effect of chelated zinc.
authors.affiliation: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address: sperlingd@centrum.cz.
authors.forename: Daniel
authors.initials: D
authors.lastname: Šperling
authors.affiliation: Institute of Infectious Diseases and Microbiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
authors.forename: Alois
authors.initials: A
authors.lastname: Čížek
authors.affiliation: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Smola
mesh_terms: D000818:Animals; D017401:Brachyspira hyodysenteriae / Q000254:growth & development*; D003106:Colon / Q000473:pathology; D004224:Diterpenes / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000662:veterinary; D004403:Dysentery / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D007413:Intestinal Mucosa / Q000473:pathology; D012685:Sepharose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
chemical_list: D004224:Diterpenes; C030523:zinc chelate-sepharose; C117845:valnemulin; D012685:Sepharose
keywords: Brachyspira; Chelated zinc; Swine dysentery; Valnemulin