title: Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo.
abstract: BACKGROUND
  Some studies suggested that Glutathione S-transferases M1/T1(GSTM1/T1) null polymorphisms may be associated with the risk of vitiligo.
  
  
  OBJECTIVE
  The purpose of this study is to further evaluate the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo.
  
  
  METHODS
  We carried out a retrieval of studies in the databases. Odds ratios (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of this association. We analyzed the data using Stata 11.0.
  
  
  RESULTS
  Six case-control studies including 1358 cases and 1673 controls were included in this meta-analysis. Our overall results showed the GSTM1 or GSTT1 null polymorphism was associated with vitiligo (GSTM1:OR=1.59, 95% CI: 1.21-2.08, P=0.001; GSTT1: OR=1.30, 95% CI: 1.12-1.51, P=0.001). In the subgroup analysis, the GSTM1 null polymorphism might be a genetic risk factor to vitiligo in East Asian (OR=1.71, 95% CI: 1.12-2.63, P=0.014) but not in the Mediterranean, however individuals with the GSTT1 null polymorphism in the Mediterranean (OR=1.76, 95% CI: 1.15-2.71, P=0.010) but not in East Asian have a greater predisposition to vitiligo. In addition there was also a significant trend toward an association with the combination of the GSTM1 null and GSTT1 null in either East Asians or Mediterraneans.
  
  
  CONCLUSIONS
  The GSTM1/T1 null polymorphisms may be associated with vitiligo. More studies are needed to confirm this conclusion.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Lechun
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: heli2661@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Division of Science and Technology, Kunming Medical University, Kunming, Yunnan, China. Electronic address: glassgreen@163.com.
authors.forename: Meihua
authors.initials: M
authors.lastname: Guo
mesh_terms: D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D014820:Vitiligo / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: 95% CIs; 95% confidence intervals; ACE; CAT; CNKI; CTLA-4; China National Knowledge Infrastructure; GSTA; GSTM; GSTM1; GSTO; GSTP; GSTT; GSTT1; GSTZ; Glutathione S-transferases M1; Glutathione S-transferases T1; Glutathione S-transferases alpha; Glutathione S-transferases mu; Glutathione S-transferases omega; Glutathione S-transferases pi; Glutathione S-transferases theta; Glutathione S-transferases zeta; MeSH; Medical Subject Terms; Meta-analysis; ORs; PTPN22; Polymorphism; SOD; Vitiligo; angiotensin-converting enzyme; catalas; cytotoxic T-lymphocyte antigen-4; odds ratios; protein tyrosine phosphatase nonreceptor type 22; superoxide dismutase