title: Mesenchymal to epithelial transition in sarcomas.
abstract: Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.
authors.affiliation: Department of Bone and Soft Tissue Tumors, National Clinical Cancer Research Center, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China. Electronic address: yangjilong@tjmuch.com.
authors.forename: Jilong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Diagnostics, Tianjin Medical University, Tianjin 300060, China. Electronic address: xiaolingdu2003@163.com.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China. Electronic address: wgwhrb@126.com.
authors.forename: Guowen
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China. Electronic address: sunyan@tjmuch.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China. Electronic address: chenkexin1963@yahoo.com.
authors.forename: Kexin
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Electronic address: xiongzengzhu@163.com.
authors.forename: Xiongzeng
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: alazar@mdanderson.org.
authors.forename: Alexander J F
authors.initials: AJ
authors.lastname: Lazar
authors.affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: khunt@mdanderson.org.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Hunt
authors.affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: rpollock@mdanderson.org.
authors.forename: Raphael E
authors.initials: RE
authors.lastname: Pollock
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: wzhang@mdanderson.org.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012509:Sarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: E-cadherin; Epithelial differentiation; Mesenchymal to epithelial transition; Micro RNA; Sarcoma; Targeted therapy; Transcriptional factors