title: GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.
abstract: Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferation and genetic deletion of GABAB1 receptor subunits increased NSC proliferation and differentiation of neuroblasts in vivo. Cell-specific conditional deletion of GABAB receptors supports a cell-autonomous role in newly generated cells. Our data indicate that signaling through GABAB receptors is an inhibitor of adult neurogenesis.
authors.affiliation: Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Giachino
authors.forename: Michael
authors.initials: M
authors.lastname: Barz
authors.forename: Jan S
authors.initials: JS
authors.lastname: Tchorz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Tome
authors.forename: Martin
authors.initials: M
authors.lastname: Gassmann
authors.forename: Josef
authors.initials: J
authors.lastname: Bischofberger
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bettler
authors.forename: Verdon
authors.initials: V
authors.lastname: Taylor
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000235:genetics; D058788:GABA-B Receptor Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D058953:Neural Stem Cells / Q000187:drug effects / Q000378:metabolism*; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000235:genetics / Q000378:metabolism; D018080:Receptors, GABA-B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; C107353:CGP 54626; D005680:gamma-Aminobutyric Acid
keywords: GABAB receptors; Mouse; Neural stem cells; Neurotransmitters