title: Is human papillomavirus associated with prostate cancer survival?
abstract: The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infection on survival in 150 primary PCa patients. One hundred twelve (74.67%) patients had positive expression of HPV E7 protein, which was evaluated in tumour tissue by immunohistochemistry. DNA analysis on a subset of cases confirmed HPV infection and revealed the presence of genotype 16. In Kaplan-Meier analysis, HPV-positive cancer patients showed worse overall survival (OS) (median 4.59 years) compared to HPV-negative (median 8.24 years, P = 0.0381). In multivariate analysis age (P < 0.001), Gleason score (P < 0.001), nuclear grading (P = 0.002), and HPV status (P = 0.034) were independent prognostic factors for OS. In our cohort, we observed high prevalence of HPV nuclear E7 oncoprotein and an association between HPV infection and PCa survival. In the debate about the oncogenic activity of HPV in PCa, our results further confirm the need for additional studies to clarify the possible role of HPV in prostate carcinogenesis.
authors.affiliation: Oncology Institute of Southern Switzerland (IOSI), Ospedale San Giovanni, 6500 Bellinzona, Switzerland.
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Pascale
authors.forename: Danae
authors.initials: D
authors.lastname: Pracella
authors.forename: Renzo
authors.initials: R
authors.lastname: Barbazza
authors.forename: Barbara
authors.initials: B
authors.lastname: Marongiu
authors.forename: Enrico
authors.initials: E
authors.lastname: Roggero
authors.forename: Serena
authors.initials: S
authors.lastname: Bonin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Stanta
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000821:virology; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000201:enzymology / Q000821:virology; D052162:Human papillomavirus 16 / Q000201:enzymology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D050725:Papillomavirus E7 Proteins / Q000378:metabolism; D030361:Papillomavirus Infections / Q000401:mortality* / Q000473:pathology / Q000821:virology; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000821:virology; D046888:Tissue Array Analysis
chemical_list: D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16