title: Process of making three-dimensional microstructures using vaporization of a sacrificial component.
abstract: Vascular structures in natural systems are able to provide high mass transport through high surface areas and optimized structure. Few synthetic material fabrication techniques are able to mimic the complexity of these structures while maintaining scalability. The Vaporization of a Sacrificial Component (VaSC) process is able to do so. This process uses sacrificial fibers as a template to form hollow, cylindrical microchannels embedded within a matrix. Tin (II) oxalate (SnOx) is embedded within poly(lactic) acid (PLA) fibers which facilitates the use of this process. The SnOx catalyzes the depolymerization of the PLA fibers at lower temperatures. The lactic acid monomers are gaseous at these temperatures and can be removed from the embedded matrix at temperatures that do not damage the matrix. Here we show a method for aligning these fibers using micromachined plates and a tensioning device to create complex patterns of three-dimensionally arrayed microchannels. The process allows the exploration of virtually any arrangement of fiber topologies and structures.
authors.affiliation: Department of Physics, University of California, Irvine.
authors.forename: Du T
authors.initials: du T
authors.lastname: Nguyen
authors.forename: Y T
authors.initials: YT
authors.lastname: Leho
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Esser-Kahn
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D021621:Imaging, Three-Dimensional / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000379:methods; D008955:Models, Cardiovascular; D010070:Oxalates / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry; D014835:Volatilization
chemical_list: D010070:Oxalates; D011091:Polyesters; D011108:Polymers; D017971:Tin Compounds; D019344:Lactic Acid; C033616:poly(lactide)