title: Polyethylene glycol (PEG-400): an efficient and recyclable reaction medium for the synthesis of pyrazolo[3,4-b]pyridin-6(7H)-one derivatives.
abstract: A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.
authors.affiliation: School of Safety Engineering, China University of Mining &Technology, Xuzhou 221116, Jiangsu, China. gldoucumt@163.com.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Zhong
authors.forename: Guolan
authors.initials: G
authors.lastname: Dou
authors.forename: Deming
authors.initials: D
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*
chemical_list: C542126:1H-pyrazol-5-amine; D000447:Aldehydes; D004146:Dioxanes; D011720:Pyrazoles; D011725:Pyridines; D011092:Polyethylene Glycols; C076489:Meldrum's acid; C023666:pyridine