title: Discovery of new G-quadruplex binding chemotypes.
abstract: We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
authors.affiliation: School of Pharmacy, University College London, London WC1N 1AX, UK. s.neidle@ucl.ac.uk.
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Ohnmacht
authors.forename: Ehsan
authors.initials: E
authors.lastname: Varavipour
authors.forename: Rupesh
authors.initials: R
authors.lastname: Nanjunda
authors.forename: Ingrida
authors.initials: I
authors.lastname: Pazitna
authors.forename: Gloria
authors.initials: G
authors.lastname: Di Vita
authors.forename: Mekala
authors.initials: M
authors.lastname: Gunaratnam
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ismail
authors.forename: David W
authors.initials: DW
authors.lastname: Boykin
authors.forename: W David
authors.initials: WD
authors.lastname: Wilson
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D005663:Furans / Q000737:chemistry; D054856:G-Quadruplexes; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; C039281:furan