title: Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos.
abstract: The periconceptional period, embracing the terminal stages of oocyte growth and post-fertilisation development up to implantation, is sensitive to parental nutrition. Deficiencies or excesses in a range of macro- and micronutrients during this period can lead to impairments in fertility, fetal development and long-term offspring health. Obesity and genotype-related differences in regional adiposity are associated with impaired liver function and insulin resistance, and contribute to fatty acid-mediated impairments in sperm viability and oocyte and embryo quality, all of which are associated with endoplasmic reticulum stress and compromised fertility. Disturbances to maternal protein metabolism can elevate ammonium concentrations in reproductive tissues and disturb embryo and fetal development. Associated with this are disturbances to one-carbon metabolism, which can lead to epigenetic modifications to DNA and associated proteins in offspring that are both insulin resistant and hypertensive. Many enzymes involved in epigenetic gene regulation use metabolic cosubstrates (e.g. acetyl CoA and S-adenosyl methionine) to modify DNA and associated proteins, and so act as 'metabolic sensors' providing a link between parental nutritional status and gene regulation. Separate to their genomic contribution, spermatozoa can also influence embryo development via direct interactions with the egg and by seminal plasma components that act on oviductal and uterine tissues.
authors.affiliation: School of Biosciences, University of Nottingham, Sutton Bonington, Leicestershire, LE12 5RD, UK.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Sinclair
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Watkins
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism*; D047108:Embryonic Development; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D005260:Female; D005298:Fertility; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009752:Nutritional Status; D009865:Oocytes / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D013094:Spermatozoa / Q000378:metabolism