title: JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?
abstract: APOL1 nephropathy occurs in a minority of genetically at-risk individuals, suggesting that other factors, such as other genes or environmental factors, contribute. Divers and colleagues report that among individuals with two APOL1 risk alleles, those with JC viruria are less likely to manifest kidney disease compared with those lacking JC viruria. These data might suggest that JC virus infection confers protection against glomerular injury, perhaps by altering cell function or generating immunity against a related polyomavirus.
authors.affiliation: Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Kopp
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D007674:Kidney Diseases / Q000235:genetics* / Q000821:virology*; D008075:Lipoproteins, HDL / Q000235:genetics*; D008297:Male; D027601:Polyomavirus Infections / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology*
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL