title: Latent IgA deposition from donor kidneys does not affect transplant prognosis, irrespective of mesangial expansion.
abstract: BACKGROUND
  Latent mesangial immunoglobulin A (IgA) deposition in the donated kidney has been investigated in the context of kidney transplantation. However, few studies have examined the impact of mesangial expansion accompanied with IgA deposition. Therefore, we investigated the effects of latent IgA deposition and mesangial expansion on transplant prognosis following living-donor kidney transplantation.
  
  
  METHODS
  We retrospectively analyzed 68 consecutive adult living-donor kidney transplantations performed at Kagawa University Hospital. Biopsies were performed at pre-implantation and at one year after transplantation.
  
  
  RESULTS
  Twenty kidneys exhibited latent IgA deposition in pre-implantation biopsies, including 14 with mesangial expansion. Latent IgA deposition was not associated with renal function or donor urinalysis after donation, irrespective of mesangial expansion. Latent IgA deposition was not significantly associated with graft survival rate, allograft function, abnormal urinalysis, or the recurrence of IgA nephropathy, irrespective of mesangial expansion. At one year after transplantation, IgA deposition had disappeared in 14/20 allografts. Estimated glomerular function rate >40 mL/min/1.73 m(2) was significantly associated with the disappearance of IgA deposition.
  
  
  CONCLUSIONS
  The present study showed that latent IgA deposition from the donor kidney, irrespective of mesangial expansion, does not affect transplant prognosis following living-donor kidney transplantation.
authors.affiliation: Division of Nephrology and Dialysis, Department of CardioRenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sofue
authors.forename: Masashi
authors.initials: M
authors.lastname: Inui
authors.forename: Taiga
authors.initials: T
authors.lastname: Hara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Moritoki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishioka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nishijima
authors.forename: Kumiko
authors.initials: K
authors.lastname: Moriwaki
authors.forename: Yushi
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Nobufumi
authors.initials: N
authors.lastname: Ueda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Reiji
authors.initials: R
authors.lastname: Haba
authors.forename: Akira
authors.initials: A
authors.lastname: Nishiyama
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kakehi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kohno
mesh_terms: D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D005920:Glomerular Mesangium / Q000473:pathology*; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: IgA deposition; IgA nephropathy; kidney transplantation; living-donor; mesangial expansion