title: [Cell replacement therapy for Parkinson's disease using iPS cells].
abstract: The aim of stem cell therapy for Parkinson's disease (PD) is to reconstruct local synapse formation and/or induce the release of dopamine and cytokines from grafted cells in the putamen. Fetal ventral-midbrain cells are reported to relieve the neurological symptoms of PD patients. However, not only embryonic stem cells (ESCs), but also induced pluripotent stem cells (iPSCs) are expected to provide an alternative donor cell population because of their capacity for self-renewal and pluripotency. A protocol to generate dopaminergic (DA) neurons from ESCs and iPSCs has been developed, and human ESCs were proven to function in the brain of rat and monkey PD models. The next step will be the isolation of DA neurons as a donor cell population for a safe and efficient transplantation.
authors.affiliation: Department of Clinical Application, Kyoto University, Center for iPS Cell Research and Application.
authors.forename: Jun
authors.initials: J
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation; D017690:Cell Transplantation / Q000379:methods / Q000639:trends; D016207:Cytokines / Q000378:metabolism; D003622:Dapsone / Q000031:analogs & derivatives; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000637:transplantation; D000882:Haplorhini; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D008636:Mesencephalon / Q000166:cytology / Q000196:embryology; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D011699:Putamen / Q000601:surgery; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*; D009435:Synaptic Transmission
chemical_list: D016207:Cytokines; C036115:sulfoxone; D003622:Dapsone; D004298:Dopamine