title: Expression profile of inflammatory breast cancer.
abstract: Inflammatory breast cancer is characterized by high malignancy, early and rapid lymphogenic and hematogenic metastasizing, and high mortality. The diagnosis of this form of cancer is based fully on the clinical criteria. Whole transcriptome analysis of tumor tissue specimens from patients with inflammatory breast cancer detected 137 differentially expressed mRNA (17 genes with low expression and 120 with high expression). Genes involved in the organization of inflammatory process, chemotaxis, and transcription regulation were active in the process of pathogenesis of inflammatory breast cancer.
authors.affiliation: Institue of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences; BioClinicum Laboratory; BioClinicum Research and Technological Center, Moscow; Moscow Municipal Oncological Hospital No. 62, Department of Health of Moscow, Moscow Region, Istra; P. A. Hertsen Moscow Cancer Institute, Ministry of Health and Social Development of the Russian Federation, Russia. mshkurnikov@gmail.com.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Shkurnikov
authors.forename: I N
authors.initials: IN
authors.lastname: Nechaev
authors.forename: N A
authors.initials: NA
authors.lastname: Khaustova
authors.forename: N A
authors.initials: NA
authors.lastname: Krainova
authors.forename: N A
authors.initials: NA
authors.lastname: Savelov
authors.forename: V N
authors.initials: VN
authors.lastname: Grinevich
authors.forename: E K
authors.initials: EK
authors.lastname: Saribekyan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002633:Chemotaxis / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics*; D059467:Transcriptome
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger