title: Effects on alimentary high-fat diet on thiol disulfide homeostasis in rats.
abstract: The effects of high-fat diet on the thiol disulfide homeostasis of rats were evaluated by activities of glutathione redox system functioning in the blood and liver. A short-term (30 days) high-fat diet inhibited activities of glutathione-dependent enzymes. High-fat loading for 90 days promoted the development of a compensatory response of the glutathione redox system and restoration of the thiol disulfide homeostasis. The compensatory processes in the glutathione system failed on day 180 of alimentary loading because of redox imbalance in the thiol disulfide metabolism.
authors.affiliation: Research Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok Affiliated Department of Far-Eastern Center of Respiratory Physiology and Pathology, Siberian Division of the Russian Academy of Medical Sciences, Russia. karaman@inbox.ru.
authors.forename: Yu K
authors.initials: YK
authors.lastname: Karaman
authors.forename: T P
authors.initials: TP
authors.lastname: Novgorodtseva
authors.forename: V I
authors.initials: VI
authors.lastname: Yan'kova
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D004064:Digestive System / Q000378:metabolism; D019803:Glutathione Disulfide / Q000097:blood*; D006706:Homeostasis; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019803:Glutathione Disulfide