title: Bronchial hyperresponsiveness in patients with obstructive sleep apnea syndrome.
abstract: BACKGROUND
  The relationship between obstructive sleep apnea syndrome (OSAS) and bronchial hyperresponsiveness (BHR) is not well known. In this study, we investigated the association between BHR and disease severity in patients with OSAS.
  
  
  METHODS
  Fourty seven (37 male/10 female) OSAS patients admitted with polysomnography enrolled to the study. Histamine bronchial challenge test was performed and body mass index (BMI, kg/m2) was calculated. Presence of BHR was diagnosed as positivity of bronchial provocative test (BPT) (PD values ≤ 16 mg/mL). Patients were questioned with Epworth sleepiness scale (ESS).
  
  
  RESULTS
  Histamine bronchial challenge test was positive in 21 of 47 patients. There were significant negative correlations between PD 20 value and AHI (r= -0.47, p= 0.03), BMI (r= -0.45, p= 0.03), and ESS score (r= -0.45, p= 0.03) in the patients with BHR. In addition, AHI (p= 0.03), BMI (p= 0.02), ESS scores (p= 0.03) were higher in patients with BHR (21 patients) than in patients not having BHR (26 patients). Significant negative relation was found between PD 20 value and AHI (b=-0.45, p= 0.03) and significant positive relation was found between presence of BHR and AHI (p= 0.04), BMI (p= 0.03) independently of age and sex in multiple regression analysis.
  
  
  CONCLUSIONS
  BHR is common in patients with OSAS. As severity of OSAS increased, severity of BHR increased. In addition, obesity may trigger presence of BHR in patients with OSAS.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey. emelbulcun@hotmail.com.
authors.forename: Emel
authors.initials: E
authors.lastname: Bulcun
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ekici
authors.forename: Aydanur
authors.initials: A
authors.lastname: Ekici
authors.forename: Gökhan
authors.initials: G
authors.lastname: Tireli
authors.forename: Tülay
authors.initials: T
authors.lastname: Karakoç
authors.forename: Erol
authors.initials: E
authors.lastname: Şentürk
authors.forename: Volkan
authors.initials: V
authors.lastname: Altınkaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016535:Bronchial Hyperreactivity / Q000453:epidemiology*; D001985:Bronchial Provocation Tests; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*; D012894:Sleep Stages; D055815:Young Adult