title: Comparison of specific activity of granulocytopoiesis stimulators after treatment with cytostatics with different mechanisms of action.
abstract: We compared hemostimulating effects of glyciram, pantohematogen, granulocytic CSF, and D-glucuronic acid preparation on the granulocytic lineage hemopoiesis suppressed by cyclophosphamide or 5-fluorouracil. The effects hemostimulators against the background of 5-fluorouracil treatment were less pronounced that during cyclophosphamide treatment.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: T Y
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D020723:Glucuronic Acid / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D051379:Mice; D008808:Mice, Inbred CBA
chemical_list: D000276:Adjuvants, Immunologic; D001685:Biological Factors; D007166:Immunosuppressive Agents; C404022:pantohematogen; D016179:Granulocyte Colony-Stimulating Factor; D020723:Glucuronic Acid; D003520:Cyclophosphamide; D006034:Glycyrrhetinic Acid; D005472:Fluorouracil