title: Hematological parameters and coronary collateral circulation in patients with stable coronary artery disease.
abstract: BACKGROUND
  Although hematological parameters have been associated with prognosis in patients with various cardiovascular diseases, their relationship with coronary collateral (CC) circulation in patients with stable coronary artery disease (CAD) is unknown.
  
  
  OBJECTIVE
  To investigate the relationship between hematological parameters and CC vessel development in patients with stable CAD.
  
  
  METHODS
  A total of 96 patients who underwent coronary angiography were retrospectively enrolled. All study participants had at least one occluded major coronary artery. Development of CCs was classified using the method of Rentrop. Rentrop grades of 0 and 1 indicate poor CCs, whereas grades 2 and 3 indicate good CCs. Hematological parameters, including mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio, were measured. Multivariate logistic regression analysis was performed to identify independent variables.
  
  
  RESULTS
  The MPV and N/L ratio were significantly higher in the poor CC group compared with the good CC group. Negative correlations were found in the analyses comparing Rentrop score with MPV and N/L ratio (r=-0.274; P=0.012 and r=-0.339; P=0.001, respectively). In multivariate analysis, the N/L ratio was independently related to CC circulation (OR 0.762 [95% CI 0.587 to 0.988]; P=0.04).
  
  
  CONCLUSIONS
  The results suggest that N/L ratio and MPV are associated with poor CCs, and a high N/L ratio is a significant predictor of poor CC development in patients with stable CAD.
authors.affiliation: Abant Izzet Baysal University School of Medicine, Department of Cardiology, Bolu, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Ayhan
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozturk
authors.forename: Alim
authors.initials: A
authors.lastname: Erdem
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Ozlu
authors.forename: Tolga
authors.initials: T
authors.lastname: Memioglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozyasar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
keywords: Coronary collateral circulation; Hematological parameters; Mean platelet volume; Neutrophil/lymphocyte ratio