title: [Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
abstract: OBJECTIVE
  To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4 (ADAMTS-4) and ADAMTS-5 in osteoarthritis.
  
  
  METHODS
  Recent literature about the ADAMTS-4 and -5 in osteoarthritis was analyzed; the structure, function, inhibitors of the ADAMTS-4 and -5, and the relationship between the proteases and osteoarthritis were analyzed and summarized.
  
  
  RESULTS
  ADAMTS-4 and -5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein, which induced the pathogenesis of osteoarthritis.
  
  
  CONCLUSIONS
  ADAMTS-4 and -5 have been demonstrated to play important roles in osteoarthritis. It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and -5, and to promote the establishment of a clinical drug targets.
authors.affiliation: Department of Orthopedics, the General Hospital of Chinese PLA, Beijing, 100853, P.R.China.
authors.forename: Quanbo
authors.initials: Q
authors.lastname: Ji
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000071121:ADAMTS4 Protein; D000071116:ADAMTS5 Protein; D053674:Aggrecans / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010003:Osteoarthritis / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D011348:Procollagen N-Endopeptidase / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism* / Q000502:physiology; D053675:Versicans / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism / Q000502:physiology
chemical_list: D053674:Aggrecans; D016207:Cytokines; D019714:Tissue Inhibitor of Metalloproteinases; D000511:alpha-Macroglobulins; D053675:Versicans; D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human; D011348:Procollagen N-Endopeptidase; D000071121:ADAMTS4 Protein; C000603918:ADAMTS4 protein, human