title: The importance of regulatory RNAs in Staphylococcus aureus.
abstract: RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Tomasini
authors.affiliation: Genomic Research Laboratory, Department of Medical Specialties, Geneva University Hospitals, University of Geneva, Genève, Switzerland.
authors.forename: Patrice
authors.initials: P
authors.lastname: François
authors.affiliation: Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria, Australia; Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia; Department of Microbiology, Monash University, Clayton, Victoria, Australia.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Howden
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fechter
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Romby
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France. Electronic address: I.caldelari@ibmc-cnrs.unistra.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Caldelari
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D012329:RNA, Bacterial / Q000235:genetics* / Q000378:metabolism; D058727:RNA, Small Untranslated / Q000235:genetics* / Q000378:metabolism; D013211:Staphylococcus aureus / Q000235:genetics* / Q000472:pathogenicity; D013312:Stress, Physiological; D037521:Virulence Factors / Q000235:genetics
chemical_list: D012329:RNA, Bacterial; D058727:RNA, Small Untranslated; D037521:Virulence Factors
keywords: Regulatory RNA; Staphylococcus; Virulence