title: The association of UGT1A1*6 and UGT1A1*28 with irinotecan-induced neutropenia in Asians: a meta-analysis.
abstract: BACKGROUND
  The UGT1A1*28 polymorphism is known as a biomarker of irinotecan-induced neutropenia in Caucasians. However, in Asians, the UGT1A1*28 mutation is much less frequent.
  
  
  METHODS
  A meta-analysis was performed to assess the association of the UGT1A1*6 and UGT1A1*28 with neutropenia in Asians.
  
  
  RESULTS
  In a combination test of the two variations, patients with severe neutropenia displayed a 155% higher mutational load than those that were not neutropenic (ORG = 2.55; 95% CI: 1.82-3.58).
  
  
  CONCLUSIONS
  In Asians, a combination test of UGT1A1*6 and UGT1A1*28 might be a potential biomarker of irinotecan-induced neutropenia, an observation that will need additional trials for confirmation.
authors.affiliation: Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine , Shanghai , China.
authors.forename: Yi-Jing
authors.initials: YJ
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Hu
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Li
authors.forename: Jue-Min
authors.initials: JM
authors.lastname: Fang
authors.forename: Li
authors.initials: L
authors.lastname: Chu
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D044466:Asian People; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D000077146:Irinotecan; D009503:Neutropenia / Q000139:chemically induced / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D000099148:UGT1A1 Enzyme
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002166:Camptothecin; D014453:Glucuronosyltransferase; D000077146:Irinotecan; D000099148:UGT1A1 Enzyme