title: Asymmetric dimethylarginine and augmentation index in newly diagnosed patients with hypertension.
abstract: Pulse wave velocity (PWV), augmentation index (Aix), and central aortic pressure (CAP) are arterial stiffness markers of endothelial dysfunction (ED). We investigated the relationship between arterial stiffness parameters and asymmetric dimethylarginine (ADMA; a marker of ED), in newly diagnosed patients with hypertension (n = 101; 61 females). These patients were investigated in accordance with the recommendations of hypertension guidelines. Arterial stiffness was measured, and serum ADMA and C-reactive protein (CRP; a marker of inflammation) levels were determined. In both women and men, there was no difference in terms of age, body mass index, systolic and diastolic blood pressures, PWV, CAP and the levels of ADMA, while Aix and CRP levels were significantly higher in women (P = .004, P = .046, respectively). In the whole group, ADMA levels correlated with Aix (Pearson r = .237, P = .024). Our findings provide further evidence of a link between arterial stiffness and ED in newly diagnosed patients with hypertension.
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakar
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Bulucu
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Ay
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Kurt
authors.affiliation: Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey drsevketb@gmail.com.
authors.forename: Şevket
authors.initials: Ş
authors.lastname: Balta
authors.affiliation: Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Sarlak
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Akhan
authors.affiliation: Department of Internal Medicine, Kasımpaşa Hospital, Istanbul, Turkey.
authors.forename: Battal
authors.initials: B
authors.lastname: Altun
authors.affiliation: Department of Clinical Biochemistry, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Arslan
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Demirbaş
authors.affiliation: Department of Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Sağlam
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000009:adverse effects; D001011:Aorta / Q000503:physiopathology*; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; C018524:N,N-dimethylarginine; D002097:C-Reactive Protein; D001120:Arginine
keywords: ADMA; CRP; arterial stiffness; augmentation index; central aortic pressure; pulse wave velocity