title: Gold nanorod-assembled PEGylated graphene-oxide nanocomposites for photothermal cancer therapy.
abstract: Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60 W cm(-2)) for 5 min after treatment with the AuNR-PEG-GO nanocomposites for 24 h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.
authors.affiliation: Department of Chemistry, Soongsil University, Seoul, Korea.
authors.forename: Uuriintuya
authors.initials: U
authors.lastname: Dembereldorj
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Erdene-Ochir
authors.initials: EO
authors.lastname: Ganbold
authors.forename: Nam Woong
authors.initials: NW
authors.lastname: Song
authors.forename: Doseok
authors.initials: D
authors.lastname: Kim
authors.forename: Jaebum
authors.initials: J
authors.lastname: Choo
authors.forename: So Yeong
authors.initials: SY
authors.lastname: Lee
authors.forename: Sehun
authors.initials: S
authors.lastname: Kim
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Joo
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010087:Oxides / Q000737:chemistry; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D010087:Oxides; D011092:Polyethylene Glycols; D006046:Gold; D006108:Graphite