title: Noma and cervicofacial necrotizing fasciitis: clinicopathological differentiation and an illustrative case report of noma.
abstract: Noma predominantly affects malnourished young children. The pathogenesis of noma is complex and multifactorial, involving interaction between local polybacterial infection on the one hand, and malnutrition, immunosuppression, or systemic bacterial or viral infections on the other hand. Noma is considered to be an opportunistic disease, but the immediate cause is uncertain. Immunosuppression associated with a high HIV load may be an important risk factor in South Africa. Cervicofacial necrotizing fasciitis, on the other hand, occurs mainly in adults. It is frequently a consequence of an odontogenic infection and is characterized by an irregular pattern of rapidly spreading necrosis of fascia, muscle, and skin. We present an unusual case of noma in a 32-year-old malnourished HIV-seropositive female with AIDS in whom, within a period of 3 days, the initial intraoral necrotizing process spread rapidly and caused circular full thickness perforating destruction of the lower lip. Prompt diagnosis and treatment brought about control of the active disease and limited the extension of the established noma and of progression of the disease at other affected oral sites.
authors.affiliation: 1 Department of Maxillofacial and Oral Surgery, University of Limpopo , Medunsa Campus, Pretoria, South Africa .
authors.forename: Charles
authors.initials: C
authors.lastname: van Niekerk
authors.forename: Razia A G
authors.initials: RA
authors.lastname: Khammissa
authors.forename: Mario
authors.initials: M
authors.lastname: Altini
authors.forename: Johan
authors.initials: J
authors.lastname: Lemmer
authors.forename: Liviu
authors.initials: L
authors.lastname: Feller
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology*; D000328:Adult; D003937:Diagnosis, Differential; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D009625:Noma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D013019:South Africa