title: Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors.
abstract: Common chemotherapeutic agents such as vincristine often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is refractory to common analgesics and represents a challenging clinical issue. Angelicae dahuricae radix is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the active component(s) that attribute to the analgesic action have not been identified. This work described the anti-hyperalgesic effect of one coumarin component, auraptenol, in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. We reported that auraptenol dose-dependently reverted the mechanical hyperalgesia in mice within the dose range of 0.05-0.8 mg/kg. In addition, the anti-hyperalgesic effect of auraptenol was significantly blocked by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). Within the dose range studied, auraptenol did not significantly alter the general locomotor activity in mice. Taken together, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust analgesic efficacy in mice. These data support further studies to assess the potential of auraptenol as a novel analgesic for the management of neuropathic pain.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Xinxiang Medical University, Weihui, Henan, China 453100.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Wang
authors.forename: Shu-e
authors.initials: SE
authors.lastname: Cao
authors.forename: Jianmin
authors.initials: J
authors.lastname: Tian
authors.forename: Guozhe
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Zhang
authors.forename: Pingfa
authors.initials: P
authors.lastname: Li
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003374:Coumarins / Q000494:pharmacology*; D004195:Disease Models, Animal; D029001:Herbal Medicine / Q000379:methods; D006930:Hyperalgesia / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009437:Neuralgia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods; D044282:Receptor, Serotonin, 5-HT1A; D044263:Receptors, Serotonin, 5-HT1 / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000494:pharmacology; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D000700:Analgesics; D003374:Coumarins; D044263:Receptors, Serotonin, 5-HT1; D058829:Serotonin 5-HT1 Receptor Antagonists; C000591095:auraptenol; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin; D014750:Vincristine