title: Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose.
abstract: TEMPO-mediated surface oxidation of mesoporous highly crystalline Cladophora cellulose was used to introduce negative surface charges onto cellulose nanofibrils without significantly altering other structural characteristics. This enabled the investigation of the influence of mesoporous nanocellulose surface charges on aspirin chemical stability to be conducted. The negative surface charges (carboxylate content 0.44±0.01 mmol/g) introduced on the mesoporous crystalline nanocellulose significantly accelerated aspirin degradation, compared to the starting material which had significantly less surface charge (0.06±0.01 mmol/g). This effect followed from an increased aspirin amorphisation ability in mesopores of the oxidized nanocellulose. These results highlight the importance of surface charges in formulating nanocellulose for drug delivery.
authors.affiliation: Nanotechnology and Functional Materials, Department of Engineering Sciences, Ångström Laboratory, Uppsala University, PO Box 534, SE-75121 Uppsala, Sweden.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Carlsson
authors.affiliation: Nanotechnology and Functional Materials, Department of Engineering Sciences, Ångström Laboratory, Uppsala University, PO Box 534, SE-75121 Uppsala, Sweden.
authors.forename: Kai
authors.initials: K
authors.lastname: Hua
authors.affiliation: Nanotechnology and Functional Materials, Department of Engineering Sciences, Ångström Laboratory, Uppsala University, PO Box 534, SE-75121 Uppsala, Sweden. Electronic address: johan.forsgren@angstrom.uu.se.
authors.forename: Johan
authors.initials: J
authors.lastname: Forsgren
authors.affiliation: Nanotechnology and Functional Materials, Department of Engineering Sciences, Ångström Laboratory, Uppsala University, PO Box 534, SE-75121 Uppsala, Sweden. Electronic address: albert.mihranyan@angstrom.uu.se.
authors.forename: Albert
authors.initials: A
authors.lastname: Mihranyan
mesh_terms: D001241:Aspirin / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D000460:Chlorophyta / Q000737:chemistry; D003460:Crystallization; D003497:Cyclic N-Oxides / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D057139:Nanofibers; D010084:Oxidation-Reduction; D016062:Porosity; D013499:Surface Properties
chemical_list: D003497:Cyclic N-Oxides; D002482:Cellulose; D001241:Aspirin; C003959:TEMPO
keywords: Chemical stability; Cladophora cellulose; Mesoporous materials; Nanocellulose; TEMPO-mediated oxidation