title: Gender difference in Cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female.
abstract: BACKGROUND
  Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy.
  
  
  OBJECTIVE
  We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity.
  
  
  METHODS
  Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined.
  
  
  RESULTS
  The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05).
  
  
  CONCLUSIONS
  CP-induced nephrotoxicity is gender related for which the mechanisms should be determined.
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.forename: Shadi
authors.initials: S
authors.lastname: Ebrahimian
authors.forename: Mona
authors.initials: M
authors.lastname: Tooyserkani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Eshraghi-Jazi
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ashrafi
keywords: Cisplatin; Gender; Rats; Renal Insufficiency