title: Photodynamic therapy for intractable bronchial lung cancer.
abstract: OBJECTIVE
  To investigate the effectiveness and side effects of photofrin-photodynamic therapy (PDT) for intractable bronchial lung cancer.
  
  
  METHODS
  Thirty patients were classified as stage II-IV intractable bronchial lung cancer with lumen obstruction after they failed previous treatment regimens such as surgery, radiotherapy and chemotherapy. PDT was performed with 630 nm laser light (Diomed) delivered through cylinder diffusing tip quartz fibers that was passed through the biopsy channel of a flexible endoscope 48 h after intravenous injection of the photosensitizer photofrin (2mg/kg body weight). 72 h after the first irradiation, the endoscopic procedure was repeated, necrotic tissues were mechanically removed and the deep original lesions and newly exposed cancer lesions were re-treated, and, if necessary, the areas were cleaned repeatedly.
  
  
  RESULTS
  The total response rate CR+PR was 86.7%, and the mean percentage of obstruction due to tumors at different treated sites decreased from 90% to 16.7% at discharge after PDT. The KPS score was significantly improved after PDT.
  
  
  CONCLUSIONS
  PDT of intractable bronchial lung cancer effectively reduces the amount of lumen obstruction, and improves the patient's quality of life. It may be an effective palliative treatment with minor side effects on patients with advanced bronchial lung cancer.
authors.affiliation: Oncology Department of Nanfang Hospital, Southern Medical University, Guangzhou 51015, China.
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Cai
authors.forename: Wen-min
authors.initials: WM
authors.lastname: Li
authors.forename: Lan-ying
authors.initials: LY
authors.lastname: Zhang
authors.forename: Xian-wei
authors.initials: XW
authors.lastname: Wang
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Luo
authors.forename: Li-bo
authors.initials: LB
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001982:Bronchial Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D001984:Bronchial Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016084:Bronchoconstriction; D002908:Chronic Disease; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether
keywords: Intractable bronchial lung cancer; Obstruction; Photodynamic therapy; Photofrin