title: Central neurocytoma: case report of an 81-year-old and histopathologic findings.
abstract: Central Neurocytomas are rare and usually benign tumors found primarily in the lateral ventricles of the brain. Central Neurocytomas are composed of uniform round cells exhibiting neuronal differentiation and are found almost exclusively in young adults between 15 and 60 years of age. The authors report the case of an 81-year-old man with a history of severe psychosis and depression, who presented with progressive confusion and ataxia likely unrelated to a central neurocytoma of his right lateral ventricle. The patient underwent a stereotactic biopsy of the lesion, followed by Gamma Knife radiosurgery. Histopathology showed immunohistological staining for synaptophysin, neuron specific enolase (NSE) and neuronal nuclear antigen (NeuN). A review of published literature on central neurocytomas revealed that this tumor occurs most frequently in young adults with a median age between 25 and 30 years. This pathology has never been reported in patients over the age of 80. Gamma Knife radiosurgery was successful in decreasing the tumor volume by 20% at the four month follow-up, but the fact that the patient died of unrelated occurrences in the elderly cannot be ruled out. Patients with central neurocytomas commonly present with obstructive hydrocephalus and immediate treatment may be necessary to tide over urgent situations.
authors.affiliation: Departments of Neurosurgery, Hoag Memorial Hospital Presbyterian; Newport Beach, CA, USA - mmathews@uci.edu.
authors.forename: G
authors.initials: G
authors.lastname: Brant-Zawadzki
authors.forename: M S G
authors.initials: MS
authors.lastname: Mathews
authors.forename: C M
authors.initials: CM
authors.lastname: Duma
authors.forename: B
authors.initials: B
authors.lastname: Kim
authors.forename: P
authors.initials: P
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Heinemann
authors.forename: M
authors.initials: M
authors.lastname: Brant-Zawadzki