title: Preparation and characterization of Au nanoparticles capped with mercaptocarboranyl clusters.
abstract: The preparation of 3-4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, opening the way for the use of these monolayer protected clusters (MPCs) in medical applications, such as boron neutron capture therapy (BNCT). These newly prepared MPCs have been characterized by FTIR, (1)H and (11)B NMR spectroscopy, UV-visible, centrifugal particle sizing (CPS), and, in some cases, inductively coupled plasma atomic emission spectrometry (ICP-AES). Water dispersibility exhibited by these MPCs allowed the study of the cellular uptake by HeLa cells.
authors.affiliation: Institut de Ciència de Materials de Barcelona, Campus U.A.B., 08193 Bellaterra, Spain. clara@icmab.es.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Cioran
authors.forename: Francesc
authors.initials: F
authors.lastname: Teixidor
authors.forename: Željka
authors.initials: Ž
authors.lastname: Krpetić
authors.forename: Mathias
authors.initials: M
authors.lastname: Brust
authors.forename: Clara
authors.initials: C
authors.lastname: Viñas
mesh_terms: D001692:Biological Transport; D001896:Boron Compounds / Q000008:administration & dosage / Q000737:chemistry*; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry*; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D013057:Spectrum Analysis
chemical_list: D001896:Boron Compounds; D056831:Coordination Complexes; D006046:Gold