title: Interleukin-16 polymorphism is associated with an increased risk of ischemic stroke.
abstract: Clinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke. Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia. We aimed to examine the relationship between the IL-16 polymorphisms and the risk of ischemic stroke in a Chinese population. A total of 198 patients with ischemic stroke and 236 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method. We found that the rs11556218TG genotype and G allele of IL-16 were associated with significantly increased risks of ischemic stroke (TG versus TT, adjusted OR = 1.88; 95% CI, 1.15-3.07; G versus T, adjusted OR = 1.54; 95% CI, 1.05-2.27, resp.). However, there were no significant differences in the genotype and allele frequencies of IL-16 rs4778889 T/C and rs4072111 C/T polymorphisms between the two groups, even after stratification analyses by age, gender, and the presence or absence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia. These findings indicate that the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population.
authors.affiliation: Department of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Liu
authors.forename: Jian-zong
authors.initials: JZ
authors.lastname: Du
authors.forename: Yu-miao
authors.initials: YM
authors.lastname: Zhou
authors.forename: Qin-fen
authors.initials: QF
authors.lastname: Shu
authors.forename: Ya-guo
authors.initials: YG
authors.lastname: Li
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D002545:Brain Ischemia / Q000473:pathology*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D007962:Leukocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D020521:Stroke / Q000473:pathology*
chemical_list: D019410:Interleukin-16