title: Photoelimination of Streptococcus mutans with two methods of photodynamic and photothermal therapy.
abstract: BACKGROUND
  Increasing resistance of oral pathogens to conventional antibacterial agents has resulted to find alternative therapies to overcome resistance development problems; hence this in vitro study was carried out to investigate the efficacy of photoelimination of Streptococcus mutans with two methods of photodynamic and photothermal therapy.
  
  
  METHODS
  Standard Suspensions of S. mutans were treated in two groups of photodynamic therapy with Toluidine blue O and Rhadachlorin(®) and photothermal therapy by EmunDo(®) and their individual light sources, then Bacterial suspension from each treatment was subcultured on the surface of Mueller-Hinton agar plates and bacterial growth was assessed. The results were analyzed by analysis of variance and Tukey test (p<0.05).
  
  
  RESULTS
  After treatments significant reduction of S. mutans viability in planktonic culture was observed in both groups of photodynamic and photothermal therapy with no priority.
  
  
  CONCLUSIONS
  Photoelimination can be a novel modality in the eradication of S. mutans colonies in near future.
authors.affiliation: Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran; Laser Research Center of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Fekrazad
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Khoei
authors.forename: Neda
authors.initials: N
authors.lastname: Hakimiha
authors.forename: Abbas
authors.initials: A
authors.lastname: Bahador
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000379:methods; D004203:Disinfection / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010789:Phototherapy / Q000379:methods*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D014048:Tolonium Chloride / Q000008:administration & dosage*
chemical_list: D017319:Photosensitizing Agents; D014048:Tolonium Chloride
keywords: Antibacterial; Photodynamic therapy; Photothermal therapy; Streptococcus mutans