title: Endovascular embolization of cerebral arteriovenous malformations: results of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2.
abstract: This retrospective study constitutes a part of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2. Its purpose is to evaluate the feasibility, safety, and outcome of endovascular embolization for cerebral arteriovenous malformations (AVMs) in Japan. Nine hundred and eighty-seven embolization procedures were registered with JR-NET 1 and 2 (424 procedures in 122 institutions with JRNET 1 and 563 procedures in 150 institutions with JRNET 2). In total, 790 patients (80.1%) had favourable clinical outcomes defined as modified Rankin Scale (mRS) scores 0-2 at 30 days after embolization. Complete AVM obliteration by embolization alone was achieved in 90 procedures (9.1%). The procedural morbidity and mortality rate was 2.5% and 0.3% per procedure, respectively. In the multivariate logistic regression models, deep venous drainage and embolization of four or more feeding pedicles per session were significantly associated with any treatment-related complications (P = 0.02 and P = 0.003, respectively). About 6 cm or more in maximum nidus diameter had a negative correlation with complications (P = 0.003). Our study shows that embolization of cerebral AVMs was performed with a high degree of safety and a low rate of symptomatic complications in Japan.
authors.affiliation: Department of Neuroendovascular Therapy, Kohnan Hospital.
authors.forename: Ryushi
authors.initials: R
authors.lastname: Kondo
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Hidenori
authors.initials: H
authors.lastname: Endo
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyachi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ezura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sakai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data*; D057510:Endovascular Procedures / Q000706:statistics & numerical data; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000628:therapy*; D007564:Japan; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000706:statistics & numerical data; D011145:Polyvinyls / Q000627:therapeutic use; D012042:Registries; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; C450660:Onyx copolymer; D011145:Polyvinyls; D004121:Dimethyl Sulfoxide