title: Status epilepticus attributed to inadvertent intrathecal injection of cefazolin during myelography.
abstract: OBJECTIVE
  To describe a case of status epilepticus believed to be a consequence of inadvertent intrathecal administration of cefazolin in a dog undergoing a myelogram.
  
  
  METHODS
  A 4-year-old, 6.5 kg, male neutered Dachshund was referred for evaluation of an acute onset hind limb paraparesis. While performing a lumbar myelogram, cefazolin was inadvertently injected into the ventral subarachnoid space. Subsequent refractory seizure activity was attributed to the epileptogenic effects of intrathecally administered cefazolin. Supportive therapy led to eventual complete recovery.
  
  
  CONCLUSIONS
  Although epileptogenic effects of intrathecally administered cefazolin are well documented in the human and experimental animal model literature, to the authors' knowledge this has not been characterized in the veterinary literature. This case highlights the need to be diligent and mindful when one administers medications, and describes the management of a dog adversely affected as a consequence of a medical error.
authors.affiliation: Akron Veterinary Referral and Emergency Center, 1321 Centerview Circle, Akron, OH 44321.
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Griffith
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D007278:Injections, Spinal; D008297:Male; D008508:Medication Errors / Q000009:adverse effects / Q000662:veterinary*; D013226:Status Epilepticus / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin
keywords: canine; cephalosporins; contrast radiography; seizures; subarachnoid