title: Expression of so-called adhesion proteins and DNA cytometric analysis in malignant parotid tumours as predictors of clinical outcome.
abstract: Tumours of the salivary glands are rare, and account for only 0.5-1% of all tumours. We have analysed the cytoarchitectural structure of such tumours by studying 3 binding proteins that act on different parts of the glandular epithelial architecture: e-cadherin, laminin, and CD44. We analysed the DNA using image cytometry to evaluate ploidy, S-phase, and 5c exceeding rate, and to compare the biological aggressiveness of the proteins. Our goal was to correlate the degree of structural integrity and the histological grade of the injury, and to try to find new biological factors that would help to predict the evolution of disease in the salivary glands. The immunoexpression pattern of the so-called adhesion proteins of the salivary glands, when combined, yields important data about the aggressiveness of malignant neoplasms, and provides useful tools with which to predict the biological evolution of malignant lesions.
authors.affiliation: Investigation Group on Head and Neck Cancer, Aragon Health Sciences Institute, University of Zaragoza, Spain. Electronic address: doctorazua@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Azúa-Romeo
authors.affiliation: Clínica Saura, Gran Vía, Zaragoza, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Saura
authors.affiliation: Clínica Saura, Gran Vía, Zaragoza, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Guerrero
authors.affiliation: Beth Israel Medical Center, Jacobi Medical Center, Albert Einstein College of Medicine Residency in Oral and Maxillofacial Surgery Division, Oral and Maxillofacial Surgery Jacobi Medical Center, USA.
authors.forename: M
authors.initials: M
authors.lastname: Turner
authors.affiliation: Oral and Maxillofacial Surgery Division, University Hospital Miguel Servet, Zaragoza, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Saura
mesh_terms: D000235:Adenolymphoma / Q000473:pathology; D018249:Adenoma, Oxyphilic / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000473:pathology; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D015820:Cadherins / Q000032:analysis*; D018267:Carcinoma, Acinar Cell / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D019044:Image Cytometry; D007797:Laminin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000032:analysis; D010307:Parotid Neoplasms / Q000473:pathology*; D010309:Parotitis / Q000473:pathology; D011003:Ploidies; D011379:Prognosis; D016196:S Phase
chemical_list: C497483:CD44 protein, human; D015820:Cadherins; D004273:DNA, Neoplasm; D018960:Hyaluronan Receptors; D007797:Laminin; D009363:Neoplasm Proteins
keywords: Adhesion proteins; Cancer; Parotid gland; Ploidy