title: A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.
abstract: For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.
authors.affiliation: Osteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, Canada H2L 4M1 ; GREPAQ, Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine (FVM), Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, QC, Canada J2S 7C6.
authors.forename: Maxim
authors.initials: M
authors.lastname: Moreau
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lussier
authors.forename: Marc-André
authors.initials: MA
authors.lastname: d'Anjou
authors.forename: Laurent
authors.initials: L
authors.lastname: Blond
authors.forename: Johanne-Martel
authors.initials: JM
authors.lastname: Pelletier
authors.forename: Jérôme R E
authors.initials: JR
authors.lastname: del Castillo
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001696:Biomechanical Phenomena; D002356:Cartilage / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D008279:Magnetic Resonance Imaging; D009043:Motor Activity; D010003:Osteoarthritis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012044:Regression Analysis