title: [Glycemic variability and oxidative stress in children, with type 1 diabetes attending a summer camp].
abstract: OBJECTIVE
  To assess glycemic variability, oxidative stress and their relationship in children and adolescents with type 1 diabetes (T1DM) attending a summer camp.
  
  
  METHODS
  Cross-sectional study that included 54 children and adolescents with T1DM aged 7-16, attending a 7 day summer camp. Sociodemographic information, clinical data, and blood glucose values measured using an Accu-Chek Nano® glucose meter were recorded. Glucose variability markers (standard deviation [SD], low blood glucose index [LBGI], high blood glucose index [HBGI], mean amplitude of glycemic excursions [MAGE] and mean of daily differences [MODD]) were calculated. Oxidative stress was assessed by the measurement of 8-iso-prostaglandin F2 alpha (PGF2α) in a 24-hour urine sample collected at the end of the camp in 14 children.
  
  
  RESULTS
  The Median SD, MAGE and MODD indexes were in the high range (61, 131 and 58 mg/dl, respectively), LBGI in the moderate range (3.3), and HBGI in the low range (4.5). The mean HbA1c was 7.6% and the median urinary excretion rate of 8-iso-PGF2α was 864.39 pg/mg creatinine. The Spearman correlation coefficients between markers of glycemic variability (SD, HBGI, MAGE, MODD) were significant. Non-significant correlations were found between markers of glycemic variability and urinary 8-iso-PGF2α.
  
  
  CONCLUSIONS
  High glycemic variability was observed in children and adolescents attending a summer camp. However, no correlations were found between markers of glycemic variability and oxidative stress measured by urinary 8-iso-PGF2α. Further studies are needed to address the relationship between oxidative stress and glycemic variability in children with T1DM.
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España; CIBER de diabetes y enfermedades metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España. Electronic address: nataliacolomo@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Colomo
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Tapia
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
authors.forename: M R
authors.initials: MR
authors.lastname: Vallejo
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
authors.forename: F
authors.initials: F
authors.lastname: García-Torres
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España; CIBER de diabetes y enfermedades metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Rubio-Martín
authors.affiliation: Servicio de Psiquiatría, Universidad Autónoma de Madrid, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, España.
authors.forename: F F
authors.initials: FF
authors.lastname: Caballero
authors.affiliation: UGC de Pediatría, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Jiménez
authors.affiliation: Asociación de Diabéticos de Málaga (ADIMA), Málaga, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pelaez
authors.affiliation: Asociación de Diabéticos de Málaga (ADIMA), Málaga, España.
authors.forename: A M
authors.initials: AM
authors.lastname: Gómez
authors.affiliation: Asociación de Diabéticos de Málaga (ADIMA), Málaga, España.
authors.forename: I
authors.initials: I
authors.lastname: Sánchez
authors.affiliation: UGC de Pediatría, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
authors.forename: J P
authors.initials: JP
authors.lastname: López-Siguero
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España; CIBER de diabetes y enfermedades metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Soriguer
authors.affiliation: UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España; CIBER de diabetes y enfermedades metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España.
authors.forename: M S
authors.initials: MS
authors.lastname: Ruiz de Adana
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D012621:Seasons
chemical_list: D001786:Blood Glucose; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost
keywords: 8-iso-prostaglandin F2 alpha; 8-iso-prostaglandina F2 alfa; Children; Diabetes mellitus tipo 1; Estrés oxidativo; Glycemic variability; Niños; Oxidative stress; Type 1 diabetes; Variabilidad glucémica