title: [Epigenic modifications associated with low benzene exposure].
abstract: DNA methylation, mitochondrial DNA copy number and telomeres shortening are cellular modifications associated with an increasing number of tumors, cardiovascular and aging diseases. In our studies these modifications were evaluated in subjects occupationally exposed to low levels of benzene and in the general population. In peripheral blood lymphocytes a decrease of DNA methylation with the increase of personal benzene exposure was found, both in Alu and LINE-1 repetitive elements, and in the global DNA. Telomere length shortening in subjects exposed to traffic exhausts and an increase in mitochondrial DNA copy number correlated to benzene exposure was also found. DNA methylation measured in specimen repeats collected at intervals of 8 years decreased more markedly in exposed subjects than in controls. Our studies highlighted the association of epigenetic modifications of DNA with low benzene exposure.
authors.affiliation: Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. silvia.fustinoni@unimi.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Fustinoni
authors.forename: Valentina
authors.initials: V
authors.lastname: Bollati
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Bertazzi
mesh_terms: D001554:Benzene / Q000008:administration & dosage / Q000633:toxicity*; D019175:DNA Methylation; D004272:DNA, Mitochondrial; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D004272:DNA, Mitochondrial; D001554:Benzene