title: Cervical adenocarcinoma identification by testing for chromosomal abnormalities.
abstract: We report on a case of cervical adenocarcinoma in situ in a 42-year-old woman with a history of human papillomavirus infection. Repeat cytology, human papillomavirus testing, and colposcopy failed to identify the lesion. Testing of the cervical cell DNA identified chromosomal abnormalities, prompting a cervical cone biopsy, which identified adenocarcinoma in situ.
authors.affiliation: From the Department of Gynecologic Oncology, Tennessee Oncology, Nashville, Tennessee (Dr Dudley); and NeoDiagnostix, Rockville, Maryland (Dr Upender and Mr Endress). Dr Dittus is in private practice, Nashville, Tennessee. Dr. Upender is now the CEO of Naveenum, Potomac, Maryland. Mr Endress is a full-time employee and stockholder of NeoDiagnostix, which provided clinical lab testing during the care of the patient. The other authors have no relevant financial interest in the products or companies described in this article.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Dittus
authors.forename: Bunyan S
authors.initials: BS
authors.lastname: Dudley
authors.forename: Madhvi
authors.initials: M
authors.lastname: Upender
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Endress
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D000328:Adult; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D055088:Early Detection of Cancer; D005260:Female; D005820:Genetic Testing; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm