title: Sodium thiosulphate treatment of uraemic tumoral calcinosis.
abstract: OBJECTIVE
  The objective of this study was to describe the efficacy of sodium thiosulphate (STS) in tumoral calcinosis (TC).
  
  
  METHODS
  The methodology involved the reporting of four retrospective case reports of TC complicating end-stage renal disease (ESRD).
  
  
  RESULTS
  We investigated STS treatment in four patients (two men; ages 46-70 years) with TC. ESRD was secondary to nephronophthisis (n = 1), membranoproliferative glomerulonephritis (n = 1), diabetic nephropathy (n = 1), and thrombotic microangiopathy (n = 1). TC developed 3-28 years after dialysis began and resulted in articular pain (n = 4) and stiffness (n = 1). It involved shoulders and hips and was diffuse in one patient. Several treatments were tried without success. STS 12.5-25 g was given intravenously after each dialysis session for 11-14 months. Pain and stiffness rapidly disappeared and TC showed partial or total regression. Side effects during infusion included increased blood pressure (n = 1), nausea (n = 1) and vomiting (n = 1). TC did not recur after treatment discontinuation with follow-up of 1.5-12 years.
  
  
  CONCLUSIONS
  STS showed promising efficacy in this short series of TC. Further studies are warranted.
authors.affiliation: Service de Rhumatologie, Hôpital Lariboisière, 2 rue Ambroise Paré, F-75010 Paris, France. hang-korng.ea@lrb.aphp.fr.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Malbos
authors.forename: Pablo
authors.initials: P
authors.lastname: Urena-Torres
authors.forename: Martine
authors.initials: M
authors.lastname: Cohen-Solal
authors.forename: Hervé
authors.initials: H
authors.lastname: Trout
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lioté
authors.forename: Thomas
authors.initials: T
authors.lastname: Bardin
authors.forename: Hang-Korng
authors.initials: HK
authors.lastname: Ea
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology; D015994:Incidence; D007674:Kidney Diseases / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000453:epidemiology; D006435:Renal Dialysis; D012189:Retrospective Studies; D013885:Thiosulfates / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014511:Uremia / Q000188:drug therapy* / Q000453:epidemiology*; D014839:Vomiting / Q000139:chemically induced / Q000453:epidemiology
chemical_list: D013885:Thiosulfates; C017717:sodium thiosulfate
keywords: apatite; calcification; dialysis; renal failure; sodium thiosulphate; tumoral calcinosis