title: Serum levels of selected Th17 and Th22 cytokines in psoriatic patients.
abstract: BACKGROUND
  Psoriasis is a T cell-mediated inflammatory disease in which pathogenesis T helper (Th) lymphocytes (Th1, Th17, and Th22) play an important role. The aim of the study was to assess the serum levels of some cytokines involved in the Th17 and Th22 responses in psoriatic patients.
  
  
  METHODS
  The study comprised 60 psoriatic patients and 30 healthy controls. In the serum collected from psoriatic patients and healthy controls, the concentrations of IL-6, IL-12, IL-17, IL-20, IL-22, and IL-23 were examined with ELISA kits. Severity of psoriatic skin lesions was assessed by means of PASI, BSA, and PGA scores.
  
  
  RESULTS
  IL-6, IL-20, and IL-22 concentrations were significantly higher in psoriatic patients in comparison with the control group. The positive correlations between the concentrations of IL-22 and IL-20 and severity of psoriasis assessed with PASI and BSA scores as well as IL-17 and PASI score were found. There was also a positive correlation between IL-23 and IL-17 concentrations.
  
  
  CONCLUSIONS
  Results of the conducted studies suggest that Th22 response may contribute to the skin and systemic inflammatory disease in psoriasis. It seems that early identification of soluble biomarkers and initiation of well-matched treatment may prevent exacerbation and progression of psoriasis.
authors.affiliation: Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Radziwiłłowska 13, 20-080 Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Michalak-Stoma
authors.forename: Joanna
authors.initials: J
authors.lastname: Bartosińska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kowal
authors.forename: Maria
authors.initials: M
authors.lastname: Juszkiewicz-Borowiec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gerkowicz
authors.forename: Grażyna
authors.initials: G
authors.lastname: Chodorowska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000276:immunology / Q000473:pathology; D012720:Severity of Illness Index; D058504:Th17 Cells / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007378:Interleukins