title: Pazopanib is an active treatment in desmoid tumour/aggressive fibromatosis.
abstract: BACKGROUND
  Desmoid tumours/aggressive fibromatosis (DT/AF) are infrequent soft-tissue neoplasms. They usually behave as indolent diseases. However, they may grow locally infiltrating or compressing adjacent structures. The role of local treatment is limited and only a few drugs have shown activity.
  
  
  METHODS
  We report the outcome of two patients affected by progressive DT/AF treated with the angiogenesis inhibitor pazopanib in two different institutions. Both patients achieved dramatic improvement in their symptoms and radiological signs of response. The clinical benefit lasted for more than 1 year and it is still ongoing.
  
  
  CONCLUSIONS
  Pazopanib is an active treatment in DT/AF. It is the first time this has been reported.
authors.affiliation: The Royal Marsden Hospital, Sarcoma Unit, Fulham Road, SW3 6JJ London, UK. juan.martin@rmh.nhs.uk.
authors.forename: Juan
authors.initials: J
authors.lastname: Martin-Liberal
authors.forename: Charlotte
authors.initials: C
authors.lastname: Benson
authors.forename: Heather
authors.initials: H
authors.lastname: McCarty
authors.forename: Khin
authors.initials: K
authors.lastname: Thway
authors.forename: Christina
authors.initials: C
authors.lastname: Messiou
authors.forename: Ian
authors.initials: I
authors.lastname: Judson