title: Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment.
abstract: Autologous platelet-rich plasma (PRP) therapies have seen a dramatic increase in breadth and frequency of use for orthopaedic conditions in the past 5 years. Rich in many growth factors that have important implications in healing, PRP can potentially regenerate tissue via multiple mechanisms. Proposed clinical and surgical applications include spinal fusion, chondropathy, knee osteoarthritis, tendinopathy, acute and chronic soft-tissue injuries, enhancement of healing after ligament reconstruction, and muscle strains. However, for many conditions, there is limited reliable clinical evidence to guide the use of PRP. Furthermore, classification systems and identification of differences among products are needed to understand the implications of variability.
authors.forename: Wellington K
authors.initials: WK
authors.lastname: Hsu
authors.forename: Allan
authors.initials: A
authors.lastname: Mishra
authors.forename: Scott R
authors.initials: SR
authors.lastname: Rodeo
authors.forename: Freddie
authors.initials: F
authors.lastname: Fu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Terry
authors.forename: Pietro
authors.initials: P
authors.lastname: Randelli
authors.forename: S Terry
authors.initials: ST
authors.lastname: Canale
authors.forename: Frank B
authors.initials: FB
authors.lastname: Kelly
mesh_terms: D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods*; D053657:Platelet-Rich Plasma; D017410:Practice Guidelines as Topic; D017695:Soft Tissue Injuries / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*