title: Experiences with amine fluoride containing products in the management of dental hard tissue lesions focusing on Hungarian studies: a review.
abstract: Fluorides play a significant role in the promotion of oral health, fostering remineralization, inhibiting demineralization processes in the enamel, and having antibacterial activity. The effects of fluorides are mostly exerted by their topical effect. The beneficial effect of amine fluorides (AmF) on caries and dental plaque reduction has been known for a long time. The caries reducing and plaque-inhibiting effect of stannous fluoride (SnF2) was also reported. However, the combination of amine fluoride/stannous fluoride has shown a much better inhibition of plaque accumulation then these products alone. There have been several clinical studies with AmF or AmF/ SnF2 products, using toothpaste, gel, combination of toothpaste and gel/fluid, toothpaste and mouth rinse. The aim of this article is to review the clinical experiences with these products based on Hungarian studies. The first Hungarian studies with AmF containing gel were published by Szőke and Kozma (1989) and Dénes and Gábris (1991). Madléna et al. (2002) performed a study with an AmF-containing toothpaste and gel in high risk groups of adolescents. The first Hungarian study with AmF/SnF2 products was published by Bánóczy et al. (1989). Based on the favourable results of these products used in combination for 12 weeks, other studies (Madléna et al. 2004, 2012) assessed the effects of toothpastes and mouth rinse containing AmF/SnF2 on plaque accumulation, within a shorter period of time, in young adults and orthodontic patients.
  
  
  CONCLUSIONS
  Regular use of different oral hygienic products containing an AmF and AmF/SnF2 combination contributes to the prevention of plaque accumulation and consequently to the prevention of dental diseases.
authors.affiliation: Department of Paedodontics and Orthodontics, Semmelweis University, Budapest, Hungary. madlena.melinda@dent.semmelweis-univ.hu.
authors.forename: Melinda
authors.initials: M
authors.lastname: Madléna
mesh_terms: D000293:Adolescent; D000328:Adult; D000588:Amines / Q000627:therapeutic use*; D002648:Child; D003731:Dental Caries / Q000453:epidemiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000453:epidemiology / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D009067:Mouthwashes; D009909:Oral Health / Q000592:standards; D009911:Oral Hygiene Index; D014002:Tin Fluorides / Q000627:therapeutic use*; D014100:Toothpastes; D016896:Treatment Outcome
chemical_list: D000588:Amines; D004338:Drug Combinations; D009067:Mouthwashes; D014002:Tin Fluorides; D014100:Toothpastes; D005459:Fluorides