title: New anti-inflammatory triterpene from the root of Ricinus communis.
abstract: Liquid-liquid partitioning of Ricinus communis root methanol extract resulted in enrichment of compounds. Purification of the n-hexane fraction led to the isolation and characterisation of two triterpenes: one known compound lupeol (1) and a new diketone pentacyclic triterpene named as erandone (urs-6-ene-3,16-dione) (2), from the plant. Their structures were determined by various spectroscopic techniques. Crude methanolic, enriched n-hexane fraction and isolates at doses 100 mg/kg p.o. exhibited significant (P < 0.001) anti-inflammatory activity in carrageenan-induced hind paw oedema model.
authors.affiliation: a Analytical Chemistry Department , CSIR-Central Institute of Medicinal and Aromatic Plants , Lucknow 226 015 , India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Srivastava
authors.lastname: Jyotshna
authors.forename: Namita
authors.initials: N
authors.lastname: Gupta
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Maurya
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007194:India; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010146:Pain / Q000188:drug therapy; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012278:Ricinus / Q000737:chemistry*; D000094042:Lupanes
chemical_list: D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D053978:Pentacyclic Triterpenes; C000591419:erandone; C010480:lupeol; D000094042:Lupanes