title: Myrciaria cauliflora peel flour had a hypolipidemic effect in rats fed a moderately high-fat diet.
abstract: The aim of this study was to evaluate the hypolipidemic effects of Myrciaria cauliflora peel flour (MPF) in rats. Previously, it was determined the proximate composition, total phenolics, and anthocyanins of MPF. Then, groups of male rats were randomly assigned to one of the five treatment groups. The standard group received a basal diet as recommended by the American Institute of Nutrition (AIN93M). The control group (CTRL) received the AIN93M diet, which added 7% of pork lard. The jaboticaba groups had their diets similar to CTRL, but added MPF at 7 (JAB1), 10 (JAB2), or 15% (JAB3). Serum and liver cholesterol as well as serum levels of high-density lipoprotein (HDL), triglycerides (TG), and glucose were evaluated. Fecal output of lipids was also measured. MPF had expressive amounts of fibers (25.28±2.52 g/100 g), total phenolics (18.95±5.27 mg/100 g), and anthocyanins (6.82±0.18 mg/100 g). The inclusion of the MPF at three ratios, reduced serum cholesterol and TG compared with CTRL. JAB3 raised serum HDL and reduced liver cholesterol compared with CTRL. JAB3 and JAB2 reduced serum glucose compared with CTRL. JAB groups eliminated more feces and had pH values lower than CTRL. However, there was no difference in lipid fecal output between all groups. MPF has a hypolipidemic potential, especially on reducing serum cholesterol and TG. These effects can be attributed, at least in part, to its fiber and phenolic composition.
authors.affiliation: 1 Chemistry Department, Institute of Exact Sciences (ICEx), Federal University of Minas Gerais (UFMG) , Belo Horizonte, Minas Gerais, Brazil .
authors.forename: Clináscia R R
authors.initials: CR
authors.lastname: Araújo
authors.forename: Elizabethe A
authors.initials: EA
authors.lastname: Esteves
authors.forename: Nísia A V
authors.initials: NA
authors.lastname: Dessimoni-Pinto
authors.forename: Angela G
authors.initials: AG
authors.lastname: Batista
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004043:Dietary Fiber / Q000032:analysis / Q000378:metabolism; D005433:Flour / Q000032:analysis*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D027822:Myrtaceae / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D004043:Dietary Fiber; D000960:Hypolipidemic Agents; D014280:Triglycerides