title: Synthesis, analytical analysis, and medicinal aspect of novel benzimidazoles and their metal complexes.
abstract: Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known to express CCK receptors in biodistribution studies. Cholecystokinin (CCK1 and CCK2) receptor binding affinities of these analogs (IC50) are 0.802 ± 0.007 for compound C and 0.326 ± 0.012 for compound D in rat pancreatic acini. These studies have provided a new template for further development of novel agents for various related diseases.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Agrawal
authors.forename: Rishi Raj
authors.initials: RR
authors.lastname: Bhatnagar
authors.forename: Anjani
authors.initials: A
authors.lastname: Tiwari
authors.forename: Rakesh
authors.initials: R
authors.lastname: Srivastava
authors.forename: Upasana
authors.initials: U
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006168:Guinea Pigs; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D051379:Mice; D010179:Pancreas / Q000378:metabolism; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D043887:Receptor, Cholecystokinin B / Q000037:antagonists & inhibitors / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D001562:Benzimidazoles; D056831:Coordination Complexes; D006576:Heterocyclic Compounds, 4 or More Rings; D008024:Ligands; D010797:Phthalimides; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; C031000:benzimidazole