title: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression.
abstract: Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
authors.affiliation: Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del giochetto, 06124 Perugia, Italy. ilaria.bellezza@unipg.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bellezza
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Mierla
authors.forename: Alba
authors.initials: A
authors.lastname: Minelli