title: Class III compensation, represented by KRP2 overexpression, depends on V-ATPase activity in proliferative cells.
abstract: Compensation refers to an increase in cell size when the cell number is significantly decreased due to the mutation or gain of function of a gene that negatively affects the cell cycle. Given the importance of coordinated growth during organogenesis in both animal and plant systems, compensation is important to understand the mechanism of size regulation. In leaves, cell division precedes cell differentiation (which involves cell expansion); therefore, a decrease in cell number triggers enhanced cell expansion (compensated cell expansion; hereafter, CCE). Functional analyses of genes for which a loss or gain of function triggers compensation have increased our understanding of the molecular mechanisms underlying the decrease in cell number. Nevertheless, the mechanisms that induce enhanced cell expansion (the link between cell cycling and expansion), as well as the cellular machinery mediating CCE, have not been characterized. We recently characterized an important pathway involved in cell enlargement in KRP2-overexpressing plants. Here, we discuss the potential axial role of plant KRPs in triggering enlargement in cells with meristematic features.
authors.affiliation: Department of Biology; Tokyo Gakugei University; Koganei-shi, Japan.
authors.forename: Ali
authors.initials: A
authors.lastname: Ferjani
authors.affiliation: Department of Biology; Tokyo Gakugei University; Koganei-shi, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ishikawa
authors.affiliation: Laboratory of Cell Dynamics; Graduate School of Bioagricultural Sciences; Nagoya University; Nagoya, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Asaoka
authors.affiliation: Department of Biology; Tokyo Gakugei University; Koganei-shi, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Ishida
authors.affiliation: Department of Life Science; College of Science; Rikkyo University; Nishi-Ikebukuro, Japan; Research Center for Life Science; College of Science; Rikkyo University; Nishi-Ikebukuro, Japan.
authors.forename: Gorou
authors.initials: G
authors.lastname: Horiguchi
authors.affiliation: Laboratory of Cell Dynamics; Graduate School of Bioagricultural Sciences; Nagoya University; Nagoya, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Maeshima
authors.affiliation: Department of Biological Sciences; Graduate School of Science; University of Tokyo; Bunkyo-ku, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukaya
mesh_terms: D017360:Arabidopsis / Q000166:cytology* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D049109:Cell Proliferation; D048429:Cell Size; D018515:Plant Leaves / Q000166:cytology / Q000378:metabolism; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; C407546:ICK2 protein, Arabidopsis; D025262:Vacuolar Proton-Translocating ATPases
keywords: Arabidopsis; KRP2; V-ATPase; cell size; compensation; det3-1; leaf development; organ-size regulation