title: Therapeutic and protective effects of Caesalpinia gilliesii and Cajanus cajan proteins against acetaminophen overdose-induced renal damage.
abstract: The present work aims to evaluate the protective and ameliorative effects of two plant-derived proteins obtained from the seeds of Cajanus cajan and Caesalpinia gilliesii(Leguminosae) against the toxic effects of acetaminophen in kidney after chronic dose through determination of certain biochemical markers including total urea, creatinine, and kidney marker enzyme, that is, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In addition histopathological examination of intoxicated and treated kidney with both proteins was performed. The present results show a significant increase in serum total urea and creatinine, while significant decrease in GAPDH. Improvement in all biochemical parameters studied was demonstrated, which was documented by the amelioration signs in rats kidney architecture. Thus, both plant protein extracts can counteract the nephrotoxic process, minimize damage to the kidney, delay disease progression, and reduce its complications.
authors.affiliation: Therapeutical Chemistry Department, National Research Center, Cairo, Egypt han201355@yahoo.com.
authors.forename: Hanan F
authors.initials: HF
authors.lastname: Aly
authors.affiliation: Therapeutical Chemistry Department, National Research Center, Cairo, Egypt.
authors.forename: Maha Z
authors.initials: MZ
authors.lastname: Rizk
authors.affiliation: Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismaileya, Egypt.
authors.forename: Dina M
authors.initials: DM
authors.lastname: Abo-Elmatty
authors.affiliation: Pharmacognosy Department, National Research Center, Cairo, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Desoky
authors.affiliation: Pharmacognosy Department, National Research Center, Cairo, Egypt.
authors.forename: N A
authors.initials: NA
authors.lastname: Ibrahim
authors.affiliation: Therapeutical Chemistry Department, National Research Center, Cairo, Egypt.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Younis
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism; D000818:Animals; D036561:Cajanus; D003404:Creatinine / Q000097:blood; D007887:Fabaceae / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D014508:Urea / Q000097:blood
chemical_list: D010936:Plant Extracts; D010940:Plant Proteins; D020011:Protective Agents; D000082:Acetaminophen; D014508:Urea; D003404:Creatinine
keywords: Acetaminophen; Caesalpinia gilliesii; Cajanus cajan; antioxidants; cytokines