title: Changes in geometric configuration and biomechanical parameters of a rapidly growing abdominal aortic aneurysm may provide insight in aneurysms natural history and rupture risk.
abstract: BACKGROUND
  Abdominal aortic aneurysms (AAA) are currently being treated based on the maximum diameter criterion which has often been proven insufficient to determine rupture risk in case of every AAA. We analyzed a rare case of an AAA which presented an extremely fast growth focusing on biomechanical determinants that may indicate a high risk profile. The examination of such a case is expected to motivate future research towards patient-specific rupture risk estimations.
  
  
  METHODS
  An initially small AAA (maximum diameter: 4.5 cm) was followed-up and presented a growth of 1 cm in only 6-months of surveillance becoming suitable for surgical repair. Changes of morphometric characteristics regarding AAA, thrombus and lumen volumes, cross-sectional areas, thrombus maximum thickness and eccentricity, and maximum centerline curvature were recorded. Moreover biomechanical variables concerning Peak Wall Stress, AAA surface area exposed to high stress and redistribution of stress during follow-up were also assessed.
  
  
  RESULTS
  Total aneurysm volume increased from 85 to 120 ml which regarded thrombus deposition since lumen volume remained stable. Thrombus deposition was eccentric regarding anterior AAA segment while its thickness increased from 0.3 cm to 1.6 cm. Moreover there was an anterior bulging over time as depicted by an increase in maximum centerline curvature from 0.4 cm-1 to 0.5 cm-1. Peak Wall Stress (PWS) exerted on aneurysm wall did not change significantly over time, slightly decreasing from 22 N/cm2 to 21 N/cm2. At the same time the area under high wall stress remained practically constant (9.9 cm2 at initial vs 9.7 cm2 at final examination) but there was a marked redistribution of wall stress against the posterior aneurysmal wall over time.
  
  
  CONCLUSIONS
  Aneurysm area under high stress and redistribution of stress against the posterior wall due to changes in geometric configuration and thrombus deposition over time may have implications to aneurysms natural history and rupture risk.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kontopodis
authors.forename: Eleni
authors.initials: E
authors.lastname: Metaxa
authors.forename: Yannis
authors.initials: Y
authors.lastname: Papaharilaou
authors.forename: Efstratios
authors.initials: E
authors.lastname: Georgakarakos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tsetis
authors.affiliation: Vascular Surgery Department, University Hospital of Heraklion & University of Crete Medical School, PO Box 1352, Heraklion, Crete 711 10, Greece. ioannou@med.uoc.gr.
authors.forename: Christos V
authors.initials: CV
authors.lastname: Ioannou
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D001019:Aortic Rupture / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D006801:Humans; D008297:Male; D012307:Risk Factors; D013314:Stress, Mechanical; D013927:Thrombosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology