title: The promotion of antimicrobial activity on silicon substrates using a "click" immobilized short peptide.
abstract: We demonstrated, for the first time, that the short antimicrobial peptide Tet213 could be conjugated onto the silicon surface by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The modified surface exhibited excellent antimicrobial activity against S. aureus and E. coli, and low cytotoxicity to rat bone mesenchymal stem cells (rBMSCs).
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China. imwangyj@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Junjian
authors.initials: J
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000480:Alkynes; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001386:Azides; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D057930:Click Chemistry; D003300:Copper; D061565:Cycloaddition Reaction; D004926:Escherichia coli / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012825:Silicon / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000480:Alkynes; D000890:Anti-Infective Agents; D001386:Azides; D005456:Fluorescent Dyes; D010455:Peptides; D003300:Copper; D012825:Silicon