title: Pattern recognition receptors in innate immunity, host defense, and immunopathology.
abstract: Infection by pathogenic microbes initiates a set of complex interactions between the pathogen and the host mediated by pattern recognition receptors. Innate immune responses play direct roles in host defense during the early stages of infection, and they also exert a profound influence on the generation of the adaptive immune responses that ensue. An improved understanding of the pattern recognition receptors that mediate innate responses and their downstream effects after receptor ligation has the potential to lead to new ways to improve vaccines and prevent autoimmunity. This review focuses on the control of innate immune activation and the role that innate immune receptors play in helping to maintain tissue homeostasis.
authors.affiliation: Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland.
authors.forename: Rahul
authors.initials: R
authors.lastname: Suresh
authors.forename: David M
authors.initials: DM
authors.lastname: Mosser
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology*; D014612:Vaccines / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D014612:Vaccines
keywords: Toll-like receptors; antigen presentation; chemokines; damage-associated molecular patterns; pathogen-associated molecular patterns; pattern recognition receptors; vaccines