title: Apolipoprotein A-I as a carrier of lipopolysaccharide into rat hepatocytes.
abstract: Apolipoprotein A-I-mediated transport of LPS into isolated rat hepatocytes was demonstrated by means of fluorescent microscopy and spectrofluorometry. The efficiency of intracellular endotoxin transport in a complex with apolipoprotein A-I significantly exceeded the absorption of LPS without this carrier. Our results suggest that the mechanism of the anti-inflammatory effect of HDL and apolipoprotein A-I can be related to alternative pathway for metabolic degradation of this endotoxin with the involvement of lipoprotein receptors.
authors.affiliation: Research Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. dinasumenkova@mail.ru.
authors.forename: D V
authors.initials: DV
authors.lastname: Sumenkova
authors.forename: L M
authors.initials: LM
authors.lastname: Polyakov
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism*; D001692:Biological Transport; D002478:Cells, Cultured; D022781:Hepatocytes / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016632:Apolipoprotein A-I; D008070:Lipopolysaccharides