title: Oncologic photodynamic therapy: clinical strategies that modulate mechanisms of action.
abstract: Photodynamic therapy (PDT) is an elegant minimally invasive oncologic therapy. The clinical simplicity of photosensitizer (PS) drug application followed by appropriate illumination of target leading to the oxygen dependent tumor ablative Photodynamic Reaction (PDR) has gained this treatment worldwide acceptance. Yet the true potential of clinical PDT has not yet been achieved. This paper will review current mechanisms of action and treatment paradigms with critical commentary on means to potentially improve outcome using readily available clinical tools.
authors.affiliation: Medical Director 21st Century Oncology, 801 WH Smith Boulevard, Greenville, NC 27834, USA. Electronic address: rallison@rtsx.com.
authors.forename: Ron R
authors.initials: RR
authors.lastname: Allison
authors.forename: Keyvan
authors.initials: K
authors.lastname: Moghissi
mesh_terms: D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008027:Light; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*
chemical_list: D017319:Photosensitizing Agents
keywords: Mechanisms of action; Photodynamic reaction; Photodynamic therapy; Photosensitizers; Review article