title: Personal exposure levels of PAHs in the general population in northern rural area of Jiangsu Province, China.
abstract: Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds that are produced by incomplete combustion of organic matters. Studies in humans have shown associations between PAHs exposure and development of cancers. Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for estimating human exposure to PAHs. We collected 332 urinary samples from a nonoccupational population in northern rural area of Jiangsu. Levels of 2-hydroxynathalene (2-OHN), 2-hydroxyfluorene (2-OHF) and 1-hydroxypyrene (1-OHP) were measured as biomarkers to assess body PAHs burdens. Three PAH metabolites were detected in more than 80% of urinary samples. After being adjusted with urinary creatinine concentration, the urinary concentrations were determined as 2-OHF > 1-OHP > 2-OHN in terms. The medians of 2-OHN, 2-OHF, 1-OHP for the general population were 1.74, 30.01, 25.24 μmoL/moL creatinine, respectively. The results demonstrated that nonoccupational populations in northern rural area of Jiangsu were exposed to extremely high PAHs. The urinary concentration (median and geometric mean) of 2-OHN,2-OHF,1-OHP in males (1.90, 0.37 ± 0.46; 34.90, 1.53 ± 0.41; 27.84, 1.52 ± 0.29 μmoL/moL creatinine, respectively) was slightly higher than in females (1.56, 0.32 ± 0.42; 29.60, 1.48 ± 0.40; 23.13, 1.49 ± 0.32 μmoL/moL creatinine, respectively). However, only 2-OHN was different significantly between males and females.
authors.affiliation: a Department of Hygienic Analysis and Detection, School of Public Health , Nanjing Medical University , Nanjing , Jiangsu , P. R. China.
authors.forename: Wen Q
authors.initials: WQ
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Rui R
authors.initials: RR
authors.lastname: Li
authors.forename: Shu Y
authors.initials: SY
authors.lastname: Cao
authors.forename: Yu T
authors.initials: YT
authors.lastname: Ye
authors.forename: Lei
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine*; D002681:China; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D005449:Fluorenes / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009284:Naphthols / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000493:pharmacokinetics / Q000633:toxicity*; D011721:Pyrenes / Q000652:urine; D012424:Rural Population; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D005449:Fluorenes; D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C477779:2-hydroxyfluorene; C033146:1-hydroxypyrene; C028405:2-naphthol