title: Identification and preparation of sperm for ART.
abstract: State-of-the-art techniques attempt to select sperm with the best functional capacity to produce pregnancy and, subsequently, healthy offspring. A variety of approaches are now being evaluated. Future approaches may allow for selection of sperm based on sperm DNA integrity, degree of aneuploidy, or apoptosis. Other approaches involve attempting to improve the in vitro function of sperm with exposure to compounds such as pentoxifylline or platelet activating factor. In the future, we are likely to see significant improvements in the ability to select the best sperm for assisted-reproductive-technology procedures and the use of these procedures in routine clinical practice.
authors.affiliation: Department of Urology, Emory University School of Medicine, 1365 Clifton Road, Building B, Suite 1400, Atlanta, GA 30322, USA.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Mehta
authors.forename: Mark
authors.initials: M
authors.lastname: Sigman
mesh_terms: D000782:Aneuploidy; D001639:Bicarbonates / Q000494:pharmacology; D004249:DNA Damage; D006801:Humans; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D027724:Reproductive Techniques, Assisted; D012449:Safety; D013081:Sperm Motility / Q000187:drug effects; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000166:cytology / Q000502:physiology
chemical_list: D001639:Bicarbonates; D010972:Platelet Activating Factor; D010431:Pentoxifylline
keywords: Motile sperm organelle morphology examination; Semen processing; Sperm DNA fragmentation; Sperm aneuploidy; Sperm selection