title: Effect of soy product kinako and fish oil on serum lipids and glucose metabolism in women with metabolic syndrome.
abstract: OBJECTIVE
  At the doses typically used to treat hypertriacylglycerolemia, fish oil may increase low-density lipoprotein (LDL) cholesterol and blood glucose levels. The aim of the present study was to verify whether soy could attenuate the effects of fish oil on blood lipids and carbohydrate metabolism in patients with metabolic syndrome.
  
  
  METHODS
  Sixty-five women (47.9 ± 9.98 y) were studied with the use of a parallel, randomized design. The control group maintained the usual diet; the second group received 29.14 g/d of soy (kinako); the third group received 3 g/d of fish oil n-3 fatty acids; and the fourth group received fish oil (3 g/d) and kinako (29.14 g/d). Assessments were performed at baseline and after 45 and 90 d.
  
  
  RESULTS
  In relation to baseline values, fish oil increased (P < 0.05) total and LDL cholesterol, glucose, insulin, and homeostasis model assessment of insulin resistance levels after 90 d. Comparisons among groups demonstrated a decrease (P < 0.05) in total cholesterol in the fish oil and kinako group after 90 d as compared with the fish oil group. LDL cholesterol decreased (P < 0.01) in the kinako group as compared with the fish oil group. Blood glucose and homeostasis model assessment of insulin resistance levels decreased after 90 d (P < 0.01 and P < 0.05, respectively) and insulin levels decreased (P < 0.05) after 45 d when the kinako group was compared with the fish oil group.
  
  
  CONCLUSIONS
  The present study showed that kinako moderates the adverse effects of high doses of fish oil on LDL cholesterol, total cholesterol, and glucose metabolism levels.
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Andréa Name Colado
authors.initials: AN
authors.lastname: Simão
authors.forename: Marcell Alysson Batisti
authors.initials: MA
authors.lastname: Lozovoy
authors.forename: Isaias
authors.initials: I
authors.lastname: Dichi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition; D015992:Body Mass Index; D050260:Carbohydrate Metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000097:blood; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000188:drug therapy*; D008875:Middle Aged; D045730:Soy Foods; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D007328:Insulin
keywords: Fish oil; Metabolic syndrome; Soy; n-3 fatty acids