title: Standing-based office work shows encouraging signs of attenuating post-prandial glycaemic excursion.
abstract: OBJECTIVE
  The main aim of this study was to compare two days of continuous monitored capillary blood glucose (CGM) responses to sitting and standing in normally desk-based workers.
  
  
  METHODS
  This open repeated-measures study took place in a real office environment, during normal working hours and subsequent CGM overnight measures in 10 participants aged 21-61 years (8 female).
  
  
  RESULTS
  Postprandial (lunch) measures of: CGM, accelerometer movement counts (MC) heart rate, energy expenditure (EE) and overnight CGM following one afternoon of normal sitting work compared with one afternoon of the same work performed at a standing desk.
  
  
  RESULTS
  Area-under-the-curve analysis revealed an attenuated blood glucose excursion by 43% (p=0.022) following 185 min of standing (143, 95% CI 5.09 to 281.46 mmol/L min) compared to sitting work (326; 95% CI 228 to 425 mmol/L min). Compared to sitting, EE during an afternoon of standing work was 174 kcals greater (0.83 kcals/min; p=0.028). The accelerometer MC showed no differences between the afternoons of seated versus standing work; reported differences were thus a function of the standing work and not from additional physical movements around the office.
  
  
  CONCLUSIONS
  This is the first known 'office-based' study to provide CGM measures that add some of the needed mechanistic information to the existing evidence-base on why avoiding sedentary behaviour at work could lead to a reduced risk of cardiometabolic diseases.
authors.affiliation: Department of Clinical Sciences and Nutrition, The University of Chester, Chester, Cheshire, UK.
authors.forename: John P
authors.initials: JP
authors.lastname: Buckley
authors.forename: Duane D
authors.initials: DD
authors.lastname: Mellor
authors.forename: Michael
authors.initials: M
authors.lastname: Morris
authors.forename: Franklin
authors.initials: F
authors.lastname: Joseph
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D057185:Sedentary Behavior; D017132:Workplace; D055815:Young Adult
chemical_list: D001786:Blood Glucose