title: Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder.
abstract: OBJECTIVE
  This study aims to identify novel genes associated with major depressive disorder and pharmacological treatment response using animal and human mRNA studies.
  
  
  METHODS
  Weighted gene coexpression network analysis was used to uncover genes associated with stress factors in mice and to inform mRNA probe set selection in a post-mortem study of depression.
  
  
  RESULTS
  A total of 171 genes were found to be differentially regulated in response to both early and late stress protocols in a mouse study. Ten human genes, orthologous to mouse genes differentially expressed by stress, were also found to be dysregulated in depressed cases in a human post-mortem brain study from the Stanley Foundation Brain Collection.
  
  
  CONCLUSIONS
  Several novel genes associated with depression were uncovered, including NOVA1 and USP9X. Moreover, we found further evidence in support of hippocampal neurogenesis and peripheral inflammation in major depressive disorder.
authors.affiliation: King's College London, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
authors.forename: Karim
authors.initials: K
authors.lastname: Malki
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Tosto
authors.forename: Irfan
authors.initials: I
authors.lastname: Jumabhoy
authors.forename: Anbarasu
authors.initials: A
authors.lastname: Lourdusamy
authors.forename: Frans
authors.initials: F
authors.lastname: Sluyter
authors.forename: Ian
authors.initials: I
authors.lastname: Craig
authors.forename: Rudolf
authors.initials: R
authors.lastname: Uher
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Leonard C
authors.initials: LC
authors.lastname: Schalkwyk
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000090682:Neuro-Oncological Ventral Antigen; D055495:Neurogenesis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D043222:Ubiquitin Thiolesterase / Q000235:genetics*
chemical_list: D000951:Antigens, Neoplasm; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C506234:USP9X protein, human; D043222:Ubiquitin Thiolesterase