title: Signaling at the Golgi during mitosis.
abstract: The Golgi complex of mammalian cells is composed of interconnected stacks of flattened cisternae that form a continuous membrane system in the pericentriolar region of the cell. At the onset of mitosis, this so-called Golgi ribbon is converted into small tubular-vesicular clusters in a tightly regulated fragmentation process, which leads to a temporary loss of the physical Golgi-centrosome proximity. Mitotic Golgi breakdown is required for Golgi partitioning into the two daughter cells, cell cycle progression and may contribute to the dispersal of Golgi-associated signaling molecules. Here, we review our current understanding of the mechanisms that control mitotic Golgi reorganization, its biological significance, and assays that are used to study this process.
authors.affiliation: Institute of Protein Biochemistry, CNR, Naples, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Colanzi
authors.forename: Christine
authors.initials: C
authors.lastname: Sütterlin
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008938:Mitosis; D015398:Signal Transduction
keywords: Cell cycle progression; Fragmentation; Kinases; Mitotic entry; Reorganization