title: (11) C and (18) F PET radioligands for the serotonin transporter (SERT).
abstract: The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric disorders including depression, anxiety, and suicide, and is the target of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. The availability of SERT-specific positron emission tomography (PET) radioligands will allow the SERT to be studied noninvasively in living subjects through PET imaging of the SERT and occupancy studies of SSRIs. Numerous diaryl sulfide and tropane derivatives have been developed and radiolabeled with (11) C or (18) F for imaging the SERT with PET.
authors.affiliation: Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Stehouwer
authors.forename: Mark M
authors.initials: MM
authors.lastname: Goodman
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis*; D014326:Tropanes / Q000138:chemical synthesis*
chemical_list: D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D014326:Tropanes
keywords: carbon-11; diaryl sulfide; fluorine-18; nortropane; positron emission tomography; serotonin transporter