title: Radiation-induced Cochlea hair cell death: mechanisms and protection.
abstract: Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini- review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC) , are claimed to be effective at reducing radiation- inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre- examined in order to minimize the damage to cochlea hair cells.
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China E-mail : yuanyw66@aliyun.com.
authors.forename: Pei-Xin
authors.initials: PX
authors.lastname: Tan
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Du
authors.forename: Chen
authors.initials: C
authors.lastname: Ren
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Yao
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Yuan
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects*; D003051:Cochlea / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D006801:Humans; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D011837:Radiation-Protective Agents