title: Resting-state synchrony between anterior cingulate cortex and precuneus relates to body shape concern in anorexia nervosa and bulimia nervosa.
abstract: Cortical areas supporting cognitive control and salience demonstrate different neural responses to visual food cues in patients with eating disorders. This top-down cognitive control, which interacts with bottom-up appetitive responses, is tightly integrated not only in task conditions but also in the resting-state. The dorsal anterior cingulate cortex (dACC) is a key node of a large-scale network that is involved in self-referential processing and cognitive control. We investigated resting-state functional connectivity of the dACC and hypothesized that altered connectivity would be demonstrated in cortical midline structures involved in self-referential processing and cognitive control. Seed-based resting-state functional connectivity was analyzed in women with anorexia nervosa (N=18), women with bulimia nervosa (N=20) and age matched healthy controls (N=20). Between group comparisons revealed that the anorexia nervosa group exhibited stronger synchronous activity between the dACC and retrosplenial cortex, whereas the bulimia nervosa group showed stronger synchronous activity between the dACC and medial orbitofrontal cortex. Both groups demonstrated stronger synchronous activity between the dACC and precuneus, which correlated with higher scores of the Body Shape Questionnaire. The dACC-precuneus resting-state synchrony might be associated with the disorder-specific rumination on eating, weight and body shape in patients with eating disorders.
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Republic of Korea.
authors.forename: Seojung
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Republic of Korea.
authors.forename: Kyung
authors.initials: K
authors.lastname: Ran Kim
authors.affiliation: Department of Biomedical Engineering, Keimyung University, Republic of Korea.
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Ku
authors.affiliation: Mind & Mind Eating Disorder Clinic, Republic of Korea.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Republic of Korea.
authors.forename: Kee
authors.initials: K
authors.lastname: Namkoong
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Republic of Korea. Electronic address: eugenejung@yuhs.ac.
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Jung
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology; D001828:Body Image; D001931:Brain Mapping; D052018:Bulimia Nervosa / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D058407:Electroencephalography Phase Synchronization; D005260:Female; D005502:Food; D059907:Functional Neuroimaging; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000503:physiopathology; D012959:Socioeconomic Factors
keywords: Anorexia nervosa; Body shape; Bulimia nervosa; Precuneus; Resting state functional connectivity