title: RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment.
abstract: The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. In the blood of healthy donors, RHOA and CKAP2 gene expression was not detected, and low SEMA3B gene expression was observed. Significant elevation of expression of all the three genes was shown in the case of acute myelogenous leukaemia. In cases of remission of acute lymphoblastic leukaemia and myelodysplastic syndrome, no expression of all three genes was detected. The long isoform of the CKAP2 gene was highly expressed in most analysed types of leukaemia.
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Klimov
authors.forename: N L
authors.initials: NL
authors.lastname: Selivanova
authors.forename: G I
authors.initials: GI
authors.lastname: Razumnova
authors.forename: O I
authors.initials: OI
authors.lastname: Rudko
authors.forename: P K
authors.initials: PK
authors.lastname: Golovatenko-Abramov
mesh_terms: D000328:Adult; D003598:Cytoskeletal Proteins / Q000097:blood / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000097:blood / Q000235:genetics*; D010865:Pilot Projects; D020033:Protein Isoforms / Q000097:blood / Q000235:genetics; D039961:Semaphorins / Q000097:blood / Q000235:genetics*; D020742:rhoA GTP-Binding Protein / Q000097:blood / Q000235:genetics*
chemical_list: C114988:CKAP2 protein, human; D003598:Cytoskeletal Proteins; D008562:Membrane Glycoproteins; D020033:Protein Isoforms; C409766:SEMA3B protein, human; D039961:Semaphorins; C066737:RHOA protein, human; D020742:rhoA GTP-Binding Protein