title: Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements.
abstract: The dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC) have both been implicated in the cognitive control of saccadic eye movements by single neuron recording studies in nonhuman primates and functional imaging studies in humans, but their relative roles remain unclear. Here, we reversibly deactivated either dlPFC or ACC subregions in macaque monkeys while the animals performed randomly interleaved pro- and antisaccades. In addition, we explored the whole-brain functional connectivity of these two regions by applying a seed-based resting-state functional MRI analysis in a separate cohort of monkeys. We found that unilateral dlPFC deactivation had stronger behavioral effects on saccades than unilateral ACC deactivation, and that the dlPFC displayed stronger functional connectivity with frontoparietal areas than the ACC. We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC.
authors.affiliation: Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada;
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Koval
authors.forename: R Matthew
authors.initials: RM
authors.lastname: Hutchison
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Lomber
authors.forename: Stefan
authors.initials: S
authors.lastname: Everling
mesh_terms: D000818:Animals; D063132:Connectome; D003714:Denervation; D006179:Gyrus Cinguli / Q000502:physiology*; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance; D012438:Saccades
keywords: cortical cooling; functional connectivity; monkeys; saccades