title: Extended-spectrum-β-lactamase-producing Escherichia coli as intestinal colonizers in the German community.
abstract: We determined the presence of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli among 3,344 study participants from the German community. Intestinal colonization was detected in 211 persons (6.3%), without significant differences among the different age groups. The majority (95.2%) of isolates harbored CTX-M-type ESBL, with CTX-M-15 (46%) and CTX-M-1 (24.2%) as the most common types. The finding of ESBL producers and one isolate additionally producing carbapenemase OXA-244 indicates a risk of dissemination of resistant bacteria outside the hospitals.
authors.affiliation: Bavarian Health and Food Safety Authority, Erlangen, Germany.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Valenza
authors.forename: Silke
authors.initials: S
authors.lastname: Nickel
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Pfeifer
authors.forename: Christoph
authors.initials: C
authors.lastname: Eller
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Krupa
authors.forename: Verena
authors.initials: V
authors.lastname: Lehner-Reindl
authors.forename: Christiane
authors.initials: C
authors.lastname: Höller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D058345:Asymptomatic Infections; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D015870:Gene Expression; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases