title: Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium-99m fatty acid derivative for myocardical imaging.
abstract: This study reports the synthesis and evaluation studies of 6'-cyclopentadienyl tricarbonyl technetium-99m 6'-oxo-11-(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart-to-blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies.
authors.affiliation: Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 310009; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, China, 100875.
authors.forename: Huahui
authors.initials: H
authors.lastname: Zeng
authors.forename: Huabei
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiangxiang
authors.initials: X
authors.lastname: Wu
authors.forename: Fangfang
authors.initials: F
authors.lastname: Chao
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.forename: Liqing
authors.initials: L
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Jiang
authors.forename: Hongbiao
authors.initials: H
authors.lastname: Liu
authors.forename: Haifeng
authors.initials: H
authors.lastname: Hou
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhan
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Tian
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D055414:Myocardial Perfusion Imaging; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals
keywords: fatty acid; myocardium; technetium-99m; tissue distribution