title: [Clinico-prognostic analysis of course of thyroid medullary carcinoma].
abstract: Analysis of localization, character of development, sizes and metastatic potential of tumors in patients, suffering various forms of thyroid medullary carcinoma (THMC), was accomplished, permitting to establish a certain dependence of these characteristics from the recurrence occurrence frequency and lethality in groups of patients, owing different gender. The tumor diameter more than 2 cm and presence of metastases in time with diagnosis establishing have constituted the unfavorable factors, causing lethality enhancement in sporadic form of THMC. In women patients more frequent multifocal development coincide with lesser frequent metastasizing and lesser lethality in comparison with such in men. Lethality in men in sporadic form of THMC is twice as more, than in women patients, and it is explained by tumor diagnosis in them in later stages, although their postoperative life span is longer, taking into account the unfavorable impact of intraoperative age (bigger, than in men) on the results of treatment and prognosis. Lethality in inherited forms of THMC is significantly lesser, than in sporadic form, independently from impact of such existing factors, as more frequent multifocal tumor development, bilateral thyroid affection and similar frequency of metastasizing. In men the metastasizing is occurring more frequently, as it take place in cases of a sporadic form of the disease, causing higher lethality in them, comparing with such in women, suffering inherited forms of THMC.
authors.forename: A M
authors.initials: AM
authors.lastname: Kravcheniuk
authors.forename: D B
authors.initials: DB
authors.lastname: Reĭzin
authors.forename: A M
authors.initials: AM
authors.lastname: Pilets'kyĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Reĭzin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D018278:Carcinoma, Neuroendocrine; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012737:Sex Factors; D016019:Survival Analysis; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology