title: SysBioCube: A Data Warehouse and Integrative Data Analysis Platform Facilitating Systems Biology Studies of Disorders of Military Relevance.
abstract: SysBioCube is an integrated data warehouse and analysis platform for experimental data relating to diseases of military relevance developed for the US Army Medical Research and Materiel Command Systems Biology Enterprise (SBE). It brings together, under a single database environment, pathophysio-, psychological, molecular and biochemical data from mouse models of post-traumatic stress disorder and (pre-) clinical data from human PTSD patients.. SysBioCube will organize, centralize and normalize this data and provide an access portal for subsequent analysis to the SBE. It provides new or expanded browsing, querying and visualization to provide better understanding of the systems biology of PTSD, all brought about through the integrated environment. We employ Oracle database technology to store the data using an integrated hierarchical database schema design. The web interface provides researchers with systematic information and option to interrogate the profiles of pan-omics component across different data types, experimental designs and other covariates.
authors.affiliation: Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research/SAIC-Frederick Inc., Frederick, MD.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Chowbina
authors.forename: Rasha
authors.initials: R
authors.lastname: Hammamieh
authors.forename: Raina
authors.initials: R
authors.lastname: Kumar
authors.forename: Nabarun
authors.initials: N
authors.lastname: Chakraborty
authors.forename: Ruoting
authors.initials: R
authors.lastname: Yang
authors.forename: Uma
authors.initials: U
authors.lastname: Mudunuri
authors.forename: Marti
authors.initials: M
authors.lastname: Jett
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Palma
authors.forename: Robert
authors.initials: R
authors.lastname: Stephens