title: Configuration of bioreactors.
abstract: Lab-scale stirred-tank bioreactors (0.2-20 l) are used for fundamental research on animal cells and in process development and troubleshooting for large-scale production. In this chapter, different configurations of bioreactor systems are shortly discussed and setting up these different configurations is described. In addition, online measurement and control of bioreactor parameters is described, with special attention to controller settings (PID) and online measurement of oxygen consumption and carbon dioxide production. Finally, methods for determining the oxygen transfer coefficient are described.
authors.affiliation: Bioprocess Engineering, Wageningen University, Wageningen, The Netherlands, Dirk.Martens@wur.nl.
authors.forename: Dirk E
authors.initials: DE
authors.lastname: Martens
authors.forename: Evert J
authors.initials: EJ
authors.lastname: van den End
authors.forename: Mathieu
authors.initials: M
authors.lastname: Streefland
mesh_terms: D000818:Animals; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation*; D004867:Equipment Design; D009862:Online Systems / Q000295:instrumentation; D010100:Oxygen / Q000032:analysis
chemical_list: D010100:Oxygen