title: Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer.
abstract: OBJECTIVE
  To compare the efficacies and side effects of Iodine-125 (125I) seeds implantation with afterloading radiotherapy on tumor xenografts derived from Hela cells.
  
  
  METHODS
  Mice bearing Hela cells were randomly divided into three groups: two therapeutic groups receiving four 125I seeds implantation and afterloading therapy, respectively, and the one control group without any intervention. Comparisons were evaluated in aspects of curative efficacies (tumor volume, tumor inhibition rate and metastasis) and side effects (body weight, ovarian endocrine functions, skin lesion surrounding the tumor).
  
  
  RESULTS
  The xenografts tumor volume of therapeutic groups were significantly smaller than that of controls(p < 0.05),both of the 125I seeds implantation and afterloading therapy showed excellent tumor inhibition rate. Furthermore, 125I seeds implantation had milder side effects on skin, weight loss, ovarian endocrine functions.
  
  
  CONCLUSIONS
  (125)I seed implantation may be an alternative minimally invasive therapy for cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Yang
authors.forename: Fu-Quan
authors.initials: FQ
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006367:HeLa Cells / Q000528:radiation effects; D064593:Heterografts / Q000528:radiation effects; D006801:Humans; D007455:Iodine; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D011879:Radiotherapy Dosage; D011897:Random Allocation; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes; D007455:Iodine