title: First clinical application of octacalcium phosphate collagen composite in human bone defect.
abstract: We have previously demonstrated that octacalcium phosphate (OCP) collagen composite (OCP/collagen) promotes bone regeneration in a critical-sized bone defect of a rodent or canine model. This study was designed to investigate the bone regeneration of OCP/collagen in human bone defect as a first clinical trial. Two patients who had a radicular cyst or apical periodontitis consented to participate in our clinical study, and OCP/collagen was implanted into the defects after operation. Radiographic examination showed effective bone healing in each bone defect at 3 or 6 months. Likewise, computed tomography value significantly increased after implantation. Postoperative wound healing was uneventful, and neither infection nor allergic reaction against OCP/collagen was observed for the entire period. This study demonstrated that OCP/collagen would be safely used and enhanced bone regeneration in human bone defects. To reinforce the efficacy of OCP/collagen as a bone substitute material, it should be compared with other suitable comparators in the future.
authors.affiliation: 1 Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry , Sendai, Japan .
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kawai
authors.forename: Seishi
authors.initials: S
authors.lastname: Echigo
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsui
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanuma
authors.forename: Tetsu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamakura
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology* / Q000601:surgery; D002130:Calcium Phosphates / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D019919:Prosthesis Implantation; D054457:Tissue Scaffolds / Q000737:chemistry*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; C022045:octacalcium phosphate; D003094:Collagen