title: Somatic cell nuclear transfer in Oregon: expanding the pluripotent space and informing research ethics.
abstract: In May, Oregon Health and Science University (OHSU) announced the successful derivation, by the Mitalipov laboratory, of embryonic stem cells by somatic cell nuclear transfer. This experiment was recognized as a "formidable technical feat" and potentially a key step toward developing cell-based therapies. The OHSU report is also an example of how a scientific breakthrough can inform research ethics. This article suggests ways that nuclear transfer embryonic stem cell lines may contribute to research ethics by adding rigor to studies addressing pressing research questions important to the development of cell-based therapies.
authors.affiliation: California Institute of Regenerative Medicine , San Francisco, California.
authors.forename: Geoffrey P
authors.initials: GP
authors.lastname: Lomax
authors.forename: Natalie D
authors.initials: ND
authors.lastname: DeWitt
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D064987:Cell- and Tissue-Based Therapy / Q000639:trends*; D053595:Embryonic Stem Cells; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D053652:Nuclear Transfer Techniques; D009922:Oregon