title: Cancer stem cells in pancreatic cancer.
abstract: Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC therapy in pancreatic cancer.
authors.affiliation: Department of Surgery, Ludwig Maximilian University of Munich, Klinikum Grosshadern, Marchioninistr. 15, D-81377, Munich, Germany. christiane.bruns@med.uni-muenchen.de.
authors.forename: Qi
authors.initials: Q
authors.lastname: Bao
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Andrea
authors.initials: A
authors.lastname: Renner
authors.forename: Hanno
authors.initials: H
authors.lastname: Niess
authors.forename: Hendrik
authors.initials: H
authors.lastname: Seeliger
authors.forename: Karl-Walter
authors.initials: KW
authors.lastname: Jauch
authors.forename: Christiane J
authors.initials: CJ
authors.lastname: Bruns