title: Tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy.
abstract: OBJECTIVE
  Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.
  
  
  METHODS
  Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.
  
  
  RESULTS
  Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.
  
  
  CONCLUSIONS
  Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
authors.affiliation: Clinic of Nephrology, Clinical Center of Serbia, Pasterova 2, 11 000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Simic Ogrizovic
authors.forename: Suzana
authors.initials: S
authors.lastname: Bojic
authors.forename: Gordana
authors.initials: G
authors.lastname: Basta-Jovanovic
authors.forename: Sanja
authors.initials: S
authors.lastname: Radojevic
authors.forename: Jelena
authors.initials: J
authors.lastname: Pavlovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur Stevuljevic
authors.forename: Violeta
authors.initials: V
authors.lastname: Dopsaj
authors.forename: Radomir
authors.initials: R
authors.lastname: Naumovic
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D005260:Female; D005355:Fibrosis / Q000175:diagnosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus