title: Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.
abstract: BACKGROUND
  Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.
  
  
  METHODS
  We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.
  
  
  CONCLUSIONS
  Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.
authors.affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Scelsi
authors.forename: Niccolò
authors.initials: N
authors.lastname: Mevio
authors.forename: Giulia
authors.initials: G
authors.lastname: Bertino
authors.forename: Antonio
authors.initials: A
authors.lastname: Occhini
authors.forename: Valeria
authors.initials: V
authors.lastname: Brazzelli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Morbini
authors.forename: Marco
authors.initials: M
authors.lastname: Benazzo
keywords: Merkel cell carcinoma; electrochemotherapy; head and neck cancer; palliative treatment