title: Three new ursane-type triterpenoids from the stems of Saprosma merrillii.
abstract: Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1-3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. chgying123@163.com.
authors.forename: Dashuai
authors.initials: D
authors.lastname: Zhang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Chen
authors.forename: Wenxing
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Song
authors.forename: Changri
authors.initials: C
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Guangying
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D053978:Pentacyclic Triterpenes
chemical_list: D010936:Plant Extracts; D014315:Triterpenes; C000606873:ursane; D053978:Pentacyclic Triterpenes