title: Tumor-to-tumor metastasis with endometrial carcinoma metastatic to squamous cell carcinoma of vulva: the first reported case.
abstract: Endometrial carcinoma metastasizing to the vulva is a rare occurrence, with only 15 reported cases in the literature. To our knowledge, no cases of tumor-to-tumor metastasis involving endometrial carcinoma as a donor tumor have ever been published. We report the first case of an endometrial carcinoma as a donor tumor metastasizing to a squamous cell carcinoma of the vulva, a recipient tumor. A 79-year-old woman with a history of endometrioid adenocarcinoma of the uterus presented with a vulvar lesion. Pathologic examination of the excised lesion confirmed the presence of metastatic endometrioid adenocarcinoma; however, it was found within a well-differentiated squamous cell carcinoma of the vulva. Surrounding the squamous cell carcinoma was a background of a high-grade vulvar intraepithelial lesion (vulvar intraepithelial neoplasia 3), and immunohistochemistry confirmed the presence of 2 separate tumors involved in a tumor-to-tumor metastasis. This unique case highlights the importance of awareness of the phenomenon, and expands the current spectrum of tumor-to-tumor metastases.
authors.affiliation: From the Departments of Pathology and Genomic Medicine (Drs Wimmer, Coffey, Ayala, and Ro) and Obstetrics and Gynecology (Dr Kaplan), The Methodist Hospital, Houston, Texas; and the Departments of Pathology and Laboratory Medicine (Drs Coffey, Ayala, and Ro), and Obstetrics and Gynecology (Dr Kaplan), Weill Cornell Medical College of Cornell University, New York, New York.
authors.forename: Jana L
authors.initials: JL
authors.lastname: Wimmer
authors.forename: Donna M
authors.initials: DM
authors.lastname: Coffey
authors.forename: Alan L
authors.initials: AL
authors.lastname: Kaplan
authors.forename: Alberto G
authors.initials: AG
authors.lastname: Ayala
authors.forename: Jae Y
authors.initials: JY
authors.lastname: Ro
mesh_terms: D000368:Aged; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000556:secondary*