title: [Advances in osteogenic mechanism and osteogenic effects of bone morphogenetic protein 6].
abstract: OBJECTIVE
  To review the osteogenic mechanism and osteogenic effects of bone morphogenetic protein 6 (BMP-6) so as to provide the basis for further research of BMP-6.
  
  
  METHODS
  The related articles about the osteogenic mechanism and the osteogenic effects of BMP-6 in experimental animals were extensively summarized.
  
  
  RESULTS
  BMP-6 from bone matrix can transduct the osteogenic signal to bone marrow mesenchymal stem cells (BMSCs) by means of Smad protein signal transduction pathway. And the BMSCs which received the signals will differentiate into osteoblasts and chondroblasts. Therefore, BMP-6 plays an important role in the development and maturation of bone and cartilage. In addition, BMP-6 has a close relation with bone diseases, such as fracture, osteoporosis, and bone tumor.
  
  
  CONCLUSIONS
  The deep research of BMP-6 is expected to provide a new therapeutic approach for treating bone diseases of nonunion, osteoarthritis, and osteoporosis.
authors.affiliation: Department of Orthopaedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233004, P.R.China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Changchun
authors.initials: C
authors.lastname: Zhang
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Hongya
authors.initials: H
authors.lastname: Meng
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001847:Bone Diseases / Q000378:metabolism / Q000628:therapy*; D055418:Bone Morphogenetic Protein 6 / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism*; D052004:Bone Morphogenetic Protein Receptors / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis; D015398:Signal Transduction; D014162:Transfection
chemical_list: D055418:Bone Morphogenetic Protein 6; D052004:Bone Morphogenetic Protein Receptors; D000469:Alkaline Phosphatase