title: Copper-catalyzed trifluoromethylation of N-arylacrylamides "on water" at room temperature.
abstract: A copper-catalyzed intramolecular trifluoromethylation of arylacrylamides leads to oxindole derivatives, effected with stable and inexpensive Langlois' reagent (CF3SO2Na). These reactions proceed via a radical process in water at room temperature. The aqueous solution can be recycled.
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Piyatida
authors.initials: P
authors.lastname: Klumphu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D000078183:Oxindoles; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D007211:Indoles; D000078183:Oxindoles; D014867:Water; C022960:2-oxindole; D003300:Copper