title: Pyruvate-enriched oral rehydration solution improved intestinal absorption of water and sodium during enteral resuscitation in burns.
abstract: OBJECTIVE
  To investigate alteration in intestinal absorption during enteral resuscitation with pyruvate-enriched oral rehydration solution (Pyr-ORS) in scalded rats.
  
  
  METHODS
  To compare pyruvate-enriched oral rehydration solution (Pyr-ORS) with World Health Organisation oral rehydration solution (WHO-ORS), 120 rats were randomly divided into 6 groups and 2 subgroups. At 1.5 and 4.5 h after a 35% TBSA scald, the intestinal absorption rate, mucosal blood flow (IMBF), Na(+)-K(+)-ATPase activity and aquaporin-1 (AQP-1) expression were determined (n = 10), respectively.
  
  
  RESULTS
  The intestinal Na(+)-K(+)-ATPase activity, AQP-1 expression and IMBF were markedly decreased in scald groups, but they were profoundly preserved by enteral resuscitation with WHO-ORS and further improved significantly with Pyr-ORS at both time points. Na(+)-K+-ATPase activities remained higher in enteral resuscitation with Pyr-ORS (Group SP) than those with WHO-ORS (Group SW) at 4.5 h. AQP-1 and IMBF were significantly greater in Group SP than in Group SW at both time points. Intestinal absorption rates of water and sodium were obviously inhibited in scald groups; however, rates were also significantly preserved in Group SP than in Group SW with an over 20% increment at both time points.
  
  
  CONCLUSIONS
  The Pyr-ORS may be superior to the standard WHO-ORS in the promotion of intestinal absorption of water and sodium during enteral resuscitation.
authors.affiliation: Laboratory of Shock and Organ Dysfunction, Burns Institute, the First Hospital Affiliated to the People's Liberation Army General Hospital, No. 51 Fu-cheng Road, Beijing 100048, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Burns and Plastic Surgery, The Armed Police General Hospital of People's Liberation Army, No. 69 Yong-ding Road, Beijing 100039, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Department of Burns and Plastic Surgery, The Armed Police General Hospital of People's Liberation Army, No. 69 Yong-ding Road, Beijing 100039, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Burns and Plastic Surgery, The Armed Police General Hospital of People's Liberation Army, No. 69 Yong-ding Road, Beijing 100039, China.
authors.forename: Zhi-long
authors.initials: ZL
authors.lastname: Lin
authors.affiliation: Laboratory of Shock and Organ Dysfunction, Burns Institute, the First Hospital Affiliated to the People's Liberation Army General Hospital, No. 51 Fu-cheng Road, Beijing 100048, China.
authors.forename: Hong-min
authors.initials: HM
authors.lastname: Luo
authors.affiliation: Department of Burns and Plastic Surgery, The Armed Police General Hospital of People's Liberation Army, No. 69 Yong-ding Road, Beijing 100039, China. Electronic address: baixiaotmu@126.com.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Bai
authors.affiliation: Laboratory of Shock and Organ Dysfunction, Burns Institute, the First Hospital Affiliated to the People's Liberation Army General Hospital, No. 51 Fu-cheng Road, Beijing 100048, China.
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Sheng
authors.affiliation: Fresenius Dialysis Centers at Chicago, Rolling Meadows Facility, No. 4180 Winnetka Ave, Rolling Meadows, IL 60008, USA. Electronic address: fqzh60130@yahoo.com.
authors.forename: Fang-qiang
authors.initials: FQ
authors.lastname: Zhou
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000187:drug effects* / Q000378:metabolism; D001639:Bicarbonates / Q000494:pharmacology; D002056:Burns; D005440:Fluid Therapy; D005947:Glucose / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D017078:Laser-Doppler Flowmetry; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D019289:Pyruvic Acid / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015532:Rehydration Solutions / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism; D014867:Water / Q000378:metabolism*
chemical_list: C496022:Aqp1 protein, rat; D001639:Bicarbonates; D015532:Rehydration Solutions; C044142:World Health Organization oral rehydration solution; D014867:Water; D051398:Aquaporin 1; D012965:Sodium Chloride; D011189:Potassium Chloride; D019289:Pyruvic Acid; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose
keywords: Aquaporin-1; Burns; Intestinal absorption; Intestinal mucosal blood flow; Na(+)-K(+)-ATPase; Oral rehydration solution; Pyruvate