title: SCOP2 prototype: a new approach to protein structure mining.
abstract: We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evolutionary relationships. SCOP2 was designed to provide a more advanced framework for protein structure annotation and classification. It defines a new approach to the classification of proteins that is essentially different from SCOP, but retains its best features. The SCOP2 classification is described in terms of a directed acyclic graph in which nodes form a complex network of many-to-many relationships and are represented by a region of protein structure and sequence. The new classification project is expected to ensure new advances in the field and open new areas of research.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK and European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Antonina
authors.initials: A
authors.lastname: Andreeva
authors.forename: Dave
authors.initials: D
authors.lastname: Howorth
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chothia
authors.forename: Eugene
authors.initials: E
authors.lastname: Kulesha
authors.forename: Alexey G
authors.initials: AG
authors.lastname: Murzin
mesh_terms: D057225:Data Mining; D030562:Databases, Protein; D020407:Internet; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000145:classification
chemical_list: D011506:Proteins