title: Increased expression of costimulatory molecules CD86 and sCTLA-4 in patients with acute lymphoblastic leukemia.
abstract: We herein evaluate the role of the B7-family molecule CD86 and the Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) as a possible immunopathogenic factors in patients with ALL. The results of 60 patients with de novo ALL were compared to 40 controls. A significant statistical difference between CD86 expression and sCTLA-4 levels in patients versus their controls has been detected. During follow up period of 28 months, patients suffered from relapse (16 patients) had significantly higher CD86 expression and sCTL-4 levels compared to those remained in complete remission (44 patients) (p = 0.005 and 0.03 respectively). Patients who died from the disease (9 patients) showed significantly higher CD 86 expression and sCTLA-4 levels than surviving patients (51 patients) (p = 0.004 and 0.01 respectively). In conclusion, the higher levels of sCTLA-4 and CD86 in B-ALL patients might be candidate parameters for poor prognosis and may serve to refine treatment stratification with intensification of therapy in those patients prone to relapse.
authors.affiliation: Clinical Pathology Department, Mansoura University , Egypt.
authors.forename: Amany
authors.initials: A
authors.lastname: Mansour
authors.forename: Tawfik
authors.initials: T
authors.lastname: Elkhodary
authors.forename: Ahmad
authors.initials: A
authors.lastname: Darwish
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mabed
mesh_terms: D000293:Adolescent; D000328:Adult; D051940:B7-2 Antigen / Q000235:genetics / Q000378:metabolism*; D060908:CTLA-4 Antigen / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D055815:Young Adult
chemical_list: D051940:B7-2 Antigen; D060908:CTLA-4 Antigen
keywords: Acute lymphoblastic leukemia; CD86; immunophenotype; sCTLA-4