title: Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene.
abstract: ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also a significant decrease in MDR1 and MRP1 gene expression. A significant reduction in expression of P-gp was found; however, there was no significant decrease in the expression of MRP1 and NF-κB p65. We conclude that regulation of membrane efflux transport protein could be a factor in benzene hematotoxicity.
authors.affiliation: Department of Occupational Disease, Jinshan Hospital, Fudan University, Shanghai, China.
authors.forename: J-S
authors.initials: JS
authors.lastname: Huang
authors.forename: M-D
authors.initials: MD
authors.lastname: Zhao
authors.forename: J-M
authors.initials: JM
authors.lastname: Shi
authors.forename: J-H
authors.initials: JH
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: Y-L
authors.initials: YL
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000378:metabolism; D001554:Benzene / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000235:genetics / Q000378:metabolism*
chemical_list: D001554:Benzene; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D051996:Transcription Factor RelA; C421109:multidrug resistance-associated protein 1