title: Lipase-catalyzed ring-opening copolymerization of ε-caprolactone and β-lactam.
abstract: The enzymatic ring-opening copolymerization of ε-caprolactone (ε-CL) and β-lactam by using Candida antarctica lipase B (CAL-B) as catalyst was studied. Variation of the feed ratios of 25:75, 50:50, and 75:25 of ε-CL/β-lactam was performed. The products contain poly(ε-CL-co-β-lactam) and the homopolymers of poly(ε-CL) and poly(β-lactam). The structure of the copolymers was determined by MALDI-ToF MS. Poly(ε-CL-co-β-lactam) has an alternating and random structure consisting of alternating repeating units with oligo(ε-CL) or oligo(β-lactam). The highest fraction of the alternating copolymers resulted from the reaction with a feed ratio 50:50. The copolymer is a semicrystalline polymer with a Tm at 124 °C and Tgs at -15 and 50 °C. Interestingly, the copolymer also demonstrated cold crystallization at 29 and 74 °C, after quenching the sample from the melt in liquid nitrogen.
authors.affiliation: Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Stavila
authors.forename: G O R
authors.initials: GO
authors.lastname: Alberda van Ekenstein
authors.forename: A J J
authors.initials: AJ
authors.lastname: Woortman
authors.forename: K
authors.initials: K
authors.lastname: Loos
mesh_terms: D002208:Caproates / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D005656:Fungal Proteins / Q000737:chemistry* / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D047090:beta-Lactams / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002208:Caproates; D005656:Fungal Proteins; D007783:Lactones; D011108:Polymers; D047090:beta-Lactams; C121056:caprolactone; D008049:Lipase; C431349:lipase B, Candida antarctica