title: Association study of common variants within the G protein-coupled receptor kinase 6 gene and schizophrenia susceptibility in Han Chinese.
abstract: In this study, we examined whether common variants in the G protein-coupled receptor kinase 6 gene (GRK6) confers susceptibility to schizophrenia in Chinese. We genotyped two common variants in 697 schizophrenia patients and 563 healthy control subjects. No significant difference in either allele or genotype comparisons between the case and control groups was found. Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese.
authors.affiliation: Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Yi
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weihong
authors.initials: W
authors.lastname: Lu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D054768:G-Protein-Coupled Receptor Kinases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D054768:G-Protein-Coupled Receptor Kinases; C089176:G-protein-coupled receptor kinase 6
keywords: G protein-coupled receptor kinase 6; polymorphism; schizophrenia