title: The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults.
abstract: The influence of gender and obesity on the abundance of human colonic Feacalibacterium prausnitzii is currently unclear. We collected fecal samples from 54 obese and 54 sex- and age-matched normal-weight Chinese adults and quantified the fecal F. prausnitzii as percentage of 16S rRNA gene copies of F. prausnitzii accounting to that of total gut bacteria with quantitative PCR. The fecal F. prausnitzii amount was not significantly different between obese and lean subjects. Men possessed significantly lower level of fecal F. prausnitzii than women, and the significant and positive correlation of fecal F. prausnitzii quantity with fasting glucose level was observed in men, not in women. Our results suggest that the gender effect, in addition to other factors including the geographic location, ethnicity, diet and gut transit times of study subjects, has to be considered when studying the relationship between gut F. prausnitzii and diseases.
authors.affiliation: Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Huang
authors.initials: H
authors.lastname: Tang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Pang
authors.forename: Linghua
authors.initials: L
authors.lastname: Wang
authors.forename: Menghui
authors.initials: M
authors.lastname: Zhang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000328:Adult; D002681:China; D005243:Feces / Q000382:microbiology*; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012737:Sex Factors
chemical_list: D012336:RNA, Ribosomal, 16S