title: Anaemia and inflammatory bowel disease.
abstract: BACKGROUND
  Anaemia has been recognised as a key symptom of IBD. Although efficient therapeutic options have been developed for the treatment of IBD associated anaemia, treating anaemia often has a low priority for gastroenterologists. Compared with other manifestations of the disease, such as arthritis or osteopathy, anaemia in IBD has been given scant attention.
  
  
  OBJECTIVE
  To evaluate prevalence of anaemia in patients treated for IBD in the Department of Gastroenterology and Hepatology, Clinical Centre, University of Sarajevo.
  
  
  METHODS
  The study was conducted between January 2010 and November 2012 as a retrospective observational clinical trial. Total of 210 patients were recruited. All patients with histopatological verification of IBD were divided into three groups, according to CDAI (Chronic Disease Activity Index): Biochemical parameters were recorded: full blood count, haemoglobin, haematocrit, RBC, WBC, proteinogram, fibrinogen, CRP.
  
  
  RESULTS
  Most of patients had haemoglobin serum level in range 100-120 g/l. Lower haemoglobin serum levels were measured in 40% of pts (CDAI>220). Lower haematocrit levels were detected in 38% of subjects with verified IBD ( CDAI>220). In the comparison of haematocrit level in the group of patients with CDAI>220 (moderate activity: 220-450 and high activity: >450) and CDAI<220 (low activity: 150-220) the statistical difference was at level p<0.04. In the comparison of haemoglobin level in the group of patients with moderate or high activity and low activity, by Student t-test the statistical difference was at level p<0.03. Hypoalbuminaemia was detected in 37.6% of patients. A significantly lower albumin level was in the group of moderate and high activity of IBD, at p<0.05 (ANOVA). Increased parameters of inflammation (CRP, fibrinogen and SE) were present in 35% of cases.
  
  
  CONCLUSIONS
  Anaemia could be the most common systemic complication of acute IBD. In our study 40 % of patients with IBD had anaemia; increased parameters of inflammation were present in 35% of cases. The control of inflammation is a key point, but often is not enough to treat anaemia. Patients should be followed up after completing treatment, and anaemia and iron deficiency actively assessed in the standard investigations.
authors.affiliation: Department of Gastroenterology and Hepatology, Clinical Centre, University of Sarajevo, Sarajevo, Bosnia and Hezegovina.
authors.forename: Nenad
authors.initials: N
authors.lastname: Vanis
authors.forename: Anila
authors.initials: A
authors.lastname: Mehmedović
authors.forename: Rusmir
authors.initials: R
authors.lastname: Mesihović
authors.forename: Aida
authors.initials: A
authors.lastname: Saray
mesh_terms: D000046:Academic Medical Centers; D000740:Anemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D017522:Bosnia and Herzegovina / Q000453:epidemiology; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D018836:Inflammation Mediators / Q000097:blood; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: C422455:ALB protein, human; D015415:Biomarkers; D006454:Hemoglobins; D018836:Inflammation Mediators; D012709:Serum Albumin; D000075462:Serum Albumin, Human