title: Codendrimer from polyamidoamine (PAMAM) and oligoethylene dendron as a thermosensitive drug carrier.
abstract: The efficient synthesis of codendrimer PAMAM-co-OEG (PAG) and its properties in aqueous solution, including particle size and thermosensitivity, are described. PAG is synthesized with well-defined structure through the "attach to" route. In the aqueous solutions, PAG forms unimer and multimolecular aggregates with the respective particle sizes of approximately 8 and 200 nm, depending on the concentration. PAG shows thermosensitive behavior with sharp and fast transition, and the lower critical solution temperature is 38.2 °C. The suitability of codendrimer PAG as the thermosensitive carrier is evaluated with methotrexate (MTX) as the model drug. MTX is encapsulated in PAG with the drug-loading capacity of 39%, among which 30% of MTX is encapsulated in PAMAM core. The release behavior of MTX mediated by temperature is investigated with focus on the effects around the LCST of PAG.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College , 151 Malianwa North Road, Beijing 100193, P. R. China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Guo
authors.forename: Yanna
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Meihua
authors.initials: M
authors.lastname: Han
authors.forename: Afang
authors.initials: A
authors.lastname: Zhang
authors.forename: Xiangtao
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D006403:Hematologic Tests; D006461:Hemolysis; D008297:Male; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D011073:Polyamines / Q000737:chemistry*; D011817:Rabbits; D013499:Surface Properties; D013696:Temperature
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D005030:Ethylenes; D008823:Micelles; C531249:Poly(amidoamine); D011073:Polyamines