title: A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum.
abstract: Cy-Cl, a cationic near-infrared cyanine dye, readily reacts with hydrogen sulfide (H2S) via nucleophilic thiolation to give dose-dependent 'turn-off' fluorescence and colorimetric read-out, allowing selective detection of low levels of H2S in serum and imaging of mitochondrial H2S in living cells.
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Biology, Xiamen University, Xiamen 361005, China.
authors.forename: Xuanjun
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Biology, Xiamen University, Xiamen 361005, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Biology, Xiamen University, Xiamen 361005, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Marine genetic Resources, The Third Institute of Oceanography, State Oceanic Administration, 184 University Road, Xiamen 361005, China; State key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China.
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Biology, Xiamen University, Xiamen 361005, China. Electronic address: shoufa@xmu.edu.cn.
authors.forename: Shoufa
authors.initials: S
authors.lastname: Han
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D008928:Mitochondria / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide
keywords: Bioimaging; Cyanine dye; Hydrogen sulfide; Mitochondria; Near-infrared; Serum