title: Prolonged respiratory viral shedding in transplant patients.
abstract: Respiratory viral infections are frequent causes of morbidity in transplant patients. We screened symptomatic adult transplant recipients for respiratory viruses in a cohort of patients attending a referral medical center in Brazil. The duration of viral shedding and the prevalence of viral codetections were also determined. During a 1-year period (2011-2012), swabs were obtained from 50 patients. An in-house polymerase chain reaction panel designed to detect 10 viruses was used. Viruses were identified in 19 (38%) patients, particularly parainfluenza III (32%) and the respiratory syncytial virus (20%); multiple viruses were identified in 26% of patients. Prolonged viral shedding was observed with 60% of individuals excreting viruses for >10 days. The clinical and epidemiologic relevance of prolonged viral shedding remains to be determined.
authors.affiliation: Department of Basic Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
authors.forename: C R A
authors.initials: CR
authors.lastname: de Lima
authors.forename: T B
authors.initials: TB
authors.lastname: Mirandolli
authors.forename: L C
authors.initials: LC
authors.lastname: Carneiro
authors.forename: C
authors.initials: C
authors.lastname: Tusset
authors.forename: C M
authors.initials: CM
authors.lastname: Romer
authors.forename: H F
authors.initials: HF
authors.lastname: Andreolla
authors.forename: L F
authors.initials: LF
authors.lastname: Baethgen
authors.forename: A C
authors.initials: AC
authors.lastname: Pasqualotto
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D060085:Coinfection; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009980:Influenza A virus / Q000235:genetics; D009981:Influenza B virus / Q000235:genetics; D007251:Influenza, Human / Q000276:immunology / Q000635:transmission; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D010222:Parainfluenza Virus 1, Human / Q000235:genetics; D010223:Parainfluenza Virus 2, Human / Q000235:genetics; D010224:Parainfluenza Virus 3, Human / Q000235:genetics; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000635:transmission; D012136:Respiratory Syncytial Viruses / Q000235:genetics; D012141:Respiratory Tract Infections / Q000276:immunology / Q000635:transmission* / Q000821:virology; D010253:Respirovirus Infections / Q000276:immunology / Q000635:transmission; D013997:Time Factors; D014777:Virus Diseases / Q000276:immunology / Q000635:transmission* / Q000821:virology; D017201:Virus Shedding; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: PCR; respiratory tract infection; transplant infectious diseases; viruses