title: Reversible stabilization of transition-metal-binding DNA G-quadruplexes.
abstract: You can't top the CopperTop: Tetramolecular G-quadruplexes modified with terminal pyridine ligands exhibit metal-triggered stabilization as monitored by thermal denaturation studies, circular dichroism, and nondenaturing gel electrophoresis. Formation of the square-planar Cu(II) (pyridine)4 complex was confirmed by EPR measurements. The metal complexation is fully reversible by removal of the transition metal with ethylenediaminetetraacetic acid (edta).
authors.affiliation: Institute of Inorganic Chemistry, Georg-August University Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany) http://www.clever-lab.de.
authors.forename: David M
authors.initials: DM
authors.lastname: Engelhard
authors.forename: Roberta
authors.initials: R
authors.lastname: Pievo
authors.forename: Guido H
authors.initials: GH
authors.lastname: Clever
mesh_terms: D003300:Copper / Q000737:chemistry; D004355:Drug Stability; D054856:G-Quadruplexes; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D008670:Metals; D028561:Transition Elements; D003300:Copper; D009532:Nickel
keywords: DNA; G-quadruplexes; bioinorganic chemistry; metal-base pair; supramolecular chemistry