title: [Clinical condition and therapy of bone diseases].
abstract: Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia, hypochondroplasia, and osteogenesis imperfecta are most frequent bone diseases. There is no curative treatment for these diseases, however, supportive therapies are available ; for example, growth-hormone therapy for achondroplasia and hypochondroplasia, and bisphosphonate therapy for osteogenesis imperfecta. In addition, enzyme replacement therapy for hypophosphatasia is now on clinical trial.
authors.affiliation: Department of pediatrics, Osaka Graduate School of Medicine, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Miura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oznono
mesh_terms: D000130:Achondroplasia / Q000209:etiology / Q000628:therapy*; D000469:Alkaline Phosphatase / Q000008:administration & dosage; D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001842:Bone and Bones / Q000002:abnormalities*; D024042:Collagen Type I / Q000235:genetics; D000090602:Collagen Type I, alpha 1 Chain; D004164:Diphosphonates / Q000008:administration & dosage; D004392:Dwarfism / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007014:Hypophosphatasia / Q000209:etiology / Q000628:therapy; D017880:Limb Deformities, Congenital / Q000209:etiology / Q000628:therapy*; D008141:Lordosis / Q000209:etiology / Q000628:therapy*; D051379:Mice; D058990:Molecular Targeted Therapy; D009154:Mutation; D020098:Natriuretic Peptide, C-Type / Q000008:administration & dosage / Q000031:analogs & derivatives; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000209:etiology / Q000628:therapy*; D000077268:Pamidronate; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D004164:Diphosphonates; D011994:Recombinant Proteins; D020098:Natriuretic Peptide, C-Type; C000632572:vosoritide; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3; D000469:Alkaline Phosphatase; D000077268:Pamidronate