title: Skin Hydration and Collagen Synthesis of AF-343 in HS68 Cell Line and NC/Nga Mice by Filaggrin Expression and Suppression of Matrix Metallopreteinase.
abstract: Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and antiinflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not fully understood yet. In this study, we have focused skin hydration mechanism related filaggrin, collagen, and matrix metalloproteinase (MMP) in vitro and animal study. Herein, skin hydration mechanism of AF-343 is due to recovery of filaggrin in mice model and increased production of collagen with suppression of matrix MMP in vitro fibroblast cell line.
authors.affiliation: Department of Dermatology, School of Medicine, Keimyung University, Daegu 700-712, Korea.
authors.forename: Jae-We
authors.initials: JW
authors.lastname: Cho
authors.forename: Yeon-Su
authors.initials: YS
authors.lastname: Jeong
authors.forename: Jiwon
authors.initials: J
authors.lastname: Han
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Chun
authors.forename: Hyun Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Min Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Ki Moon
authors.initials: KM
authors.lastname: Park
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Kim
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Soo-Muk
authors.initials: SM
authors.lastname: Cho
keywords: MMP-1; Smad2/3; Taraxacum platycarpum; Type I collagen