title: Diagnostic capability of gadoxetate disodium-enhanced liver MRI for diagnosis of hepatocellular carcinoma: comparison with multi-detector CT.
abstract: The purpose of this study was to evaluate the diagnostic capability of gadoxetate disodium (Gd-EOB)-MRI for the detection of hepatocellular carcinoma (HCC) compared with multidetector CT (MDCT). Fifty patients with 57 surgically proven HCCs who underwent Gd-EOB-MRI and MDCT from March 2008 to June 2011 were evaluated. Two observers evaluated MR and CT on a lesion-by-lesion basis. We analyzed sensitivity by grading on a 5-point scale, the degree of arterial enhancement and the differences in histological grades in the diffusion-weighted images (DWI). The results showed that the sensitivity of Gd-EOB-MRI was higher than that of MDCT especially for HCCs that were 1 cm in diameter or smaller. The hepatobiliary phase was useful for the detecting of small HCC. We had few cases in which it was difficult to judge HCC in the arterial enhancement between MRI and MDCT. In the diffusion-weighted image, well differentiated HCC tended to show a low signal intensity, and poorly differentiated HCC tended to show a high signal intensity. In moderately differentiated HCC's, the mean diameter of the high signal intensity group was larger than that of the low signal intensity group (24.5 mm vs. 15.8 mm). In conclusion, Gd-EOB-MRI tended to show higher sensitivity compared to MDCT in the detection of HCC.
authors.affiliation: Department of Diagnostic Radiology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Toyota
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Hieda
authors.forename: Naoko
authors.initials: N
authors.lastname: Akiyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Terada
authors.forename: Noriaki
authors.initials: N
authors.lastname: Matsuura
authors.forename: Masayo
authors.initials: M
authors.lastname: Nishiki
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kohno
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Irei
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kuraoka
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Taniyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology*; D002454:Cell Differentiation; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA