title: [SIBLING proteins: molecular tools for tumor progression and angiogenesis].
abstract: The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis.
authors.affiliation: Laboratoire de recherche sur les métastases, GIGA (groupe interdisciplinaire de génoprotéomique appliquée)-Cancer, Université de Liège, Building 23, Sart Tilman, 4000 Liège, Belgique.
authors.forename: Virginie
authors.initials: V
authors.lastname: Lamour
authors.forename: Marie-Julie
authors.initials: MJ
authors.lastname: Nokin
authors.forename: Aurélie
authors.initials: A
authors.lastname: Henry
authors.forename: Vincent
authors.initials: V
authors.lastname: Castronovo
authors.forename: Akeila
authors.initials: A
authors.lastname: Bellahcène
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D058574:Integrin-Binding Sialoprotein / Q000097:blood / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic; D053495:Osteopontin / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D012795:Sialoglycoproteins / Q000502:physiology*; D000099311:Dentin Sialophosphoprotein
chemical_list: D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D058574:Integrin-Binding Sialoprotein; D053495:Osteopontin; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D000099311:Dentin Sialophosphoprotein; C513309:DMP1 protein, human; C486579:MEPE protein, human