title: Liver function in workers exposed of the cosmetics industry.
abstract: BACKGROUND
  The purpose of this study is to assess whether occupational exposure to substances used in the cosmetic factories may cause effects on the liver and blood counts in exposed workers.
  
  
  METHODS
  The study included 48 exposed workers and 86 unexposed controls. All workers included in the study underwent blood count, white blood count, total, direct and indirect bilirubin, transaminases, alkaline phosphatase and cholinesterase. The differences between the means and frequencies were compared using the Student's t-test and chi-square test with Yates correction and were considered significant when the p value was <0.05.
  
  
  RESULTS
  The analysis of the results shows that 35.4% of workers in the cosmetics industry had liver test values above the range. We noted a statistically significant higher prevalence of GPT (p <0.05) and total bilirubin (p <0.05) in the workers of the cosmetics industry compared with the control group.
  
  
  CONCLUSIONS
  The results obtained suggest that occupational exposure to low doses of substances used in the cosmetic industry is able to influence some liver parameters in occupationally exposed workers.
authors.affiliation: Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Casale
authors.forename: T
authors.initials: T
authors.lastname: Caciari
authors.forename: M V
authors.initials: MV
authors.lastname: Rosati
authors.forename: M
authors.initials: M
authors.lastname: Biagi
authors.forename: S
authors.initials: S
authors.lastname: De Sio
authors.forename: G
authors.initials: G
authors.lastname: Andreozzi
authors.forename: M P
authors.initials: MP
authors.lastname: Schifano
authors.forename: A
authors.initials: A
authors.lastname: Capozzella
authors.forename: B
authors.initials: B
authors.lastname: Pimpinella
authors.forename: G
authors.initials: G
authors.lastname: Tomei
authors.forename: F
authors.initials: F
authors.lastname: Tomei
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count / Q000379:methods; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002802:Cholinesterases / Q000097:blood; D003358:Cosmetics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007221:Industry; D007558:Italy / Q000453:epidemiology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence; D000637:Transaminases / Q000097:blood
chemical_list: D015415:Biomarkers; D003358:Cosmetics; D000637:Transaminases; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D001663:Bilirubin