title: Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women.
abstract: The present study investigated the impact of a Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and maintenance in obese men and women over 24 weeks. In a double-blind, placebo-controlled, randomised trial, each subject consumed two capsules per d of either a placebo or a LPR formulation (1.6 × 10(8) colony-forming units of LPR/capsule with oligofructose and inulin). Each group was submitted to moderate energy restriction for the first 12 weeks followed by 12 weeks of weight maintenance. Body weight and composition were measured at baseline, at week 12 and at week 24. The intention-to-treat analysis showed that after the first 12 weeks and after 24 weeks, mean weight loss was not significantly different between the LPR and placebo groups when all the subjects were considered. However, a significant treatment × sex interaction was observed. The mean weight loss in women in the LPR group was significantly higher than that in women in the placebo group (P = 0.02) after the first 12 weeks, whereas it was similar in men in the two groups (P= 0.53). Women in the LPR group continued to lose body weight and fat mass during the weight-maintenance period, whereas opposite changes were observed in the placebo group. Changes in body weight and fat mass during the weight-maintenance period were similar in men in both the groups. LPR-induced weight loss in women was associated not only with significant reductions in fat mass and circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in faeces. The present study shows that the Lactobacillus rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable weight loss.
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Laval University, Quebec, QC, Canada G1V 0A6.
authors.forename: Marina
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Darimont
authors.affiliation: Department of Physical Education, Faculty of Educational Sciences, Laval University, Quebec, QC, Canada G1V 0A6.
authors.forename: Vicky
authors.initials: V
authors.lastname: Drapeau
authors.affiliation: Clinical Development Unit, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Shahram
authors.initials: S
authors.lastname: Emady-Azar
authors.affiliation: Analytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Melissa
authors.initials: M
authors.lastname: Lepage
authors.affiliation: Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Enea
authors.initials: E
authors.lastname: Rezzonico
authors.affiliation: Analytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Catherine
authors.initials: C
authors.lastname: Ngom-Bru
authors.affiliation: Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Berger
authors.affiliation: Clinical Development Unit, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Lionel
authors.initials: L
authors.lastname: Philippe
authors.affiliation: Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Corinne
authors.initials: C
authors.lastname: Ammon-Zuffrey
authors.affiliation: Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Leone
authors.affiliation: Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada G1V 4G5.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Chevrier
authors.affiliation: Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada G1V 4G5.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: St-Amand
authors.affiliation: Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada G1V 4G5.
authors.forename: André
authors.initials: A
authors.lastname: Marette
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Laval University, Quebec, QC, Canada G1V 0A6.
authors.forename: Jean
authors.initials: J
authors.lastname: Doré
authors.affiliation: Department of Kinesiology, Faculty of Medicine, Laval University, Quebec, QC, Canada G1V 0A6.
authors.forename: Angelo
authors.initials: A
authors.lastname: Tremblay
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D003106:Colon / Q000382:microbiology; D019587:Dietary Supplements; D004311:Double-Blind Method; D002149:Energy Intake; D005243:Feces; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D052201:Lacticaseibacillus rhamnosus; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D019936:Probiotics / Q000627:therapeutic use*; D012737:Sex Factors; D015431:Weight Loss; D055815:Young Adult
chemical_list: D020738:Leptin