title: Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique.
abstract: The aim of this study was to prepare dextrin nanoparticles by emulsion cross-linking technique. The nanoparticles were prepared from nanoemulsion templates produced by high power ultrasonication. The influence of hydrophilic-lipophilic balance (HLB), surfactant type and concentration, water content, and sonication time on the template size were examined in order to find optimal conditions for preparing dextrin nanoparticles. Nano-scaled templates were achieved when mixed surfactants (Span80/Tween80 and Span80/Brij30) at HLB 6 were used while using Span80 or other HLB values resulted in micron-sized templates. The smallest emulsion templates were achieved when using 7% (w/w) mixture of Span80/Tween80 at HLB 6, 15% (w/w) water, and sonication time of 30min. The spherical dextrin nanoparticles possessed a slight negative charge on the surface. FTIR spectra confirmed that dextrin was cross-linked by glyoxal. This study developed a novel way of formulating dextrin nanoparticles, which may prove to be useful in future for drug delivery.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand; Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
authors.forename: Somkamol
authors.initials: S
authors.lastname: Manchun
authors.forename: Crispin R
authors.initials: CR
authors.lastname: Dass
authors.forename: Pornsak
authors.initials: P
authors.lastname: Sriamornsak
mesh_terms: D003912:Dextrins / Q000737:chemistry*; D015195:Drug Design; D004655:Emulsions; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D013010:Sonication; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D003912:Dextrins; D004655:Emulsions; D013501:Surface-Active Agents; D014867:Water
keywords: Dextrin; Emulsion crosslinking technique; Nanoparticles; Ultrasonication