title: Cost-utility of self-managed computer therapy for people with aphasia.
abstract: OBJECTIVE
  The aim of this study was to examine the potential cost-effectiveness of self-managed computer therapy for people with long-standing aphasia post stroke and to estimate the value of further research.
  
  
  METHODS
  The incremental cost-effectiveness ratio of computer therapy in addition to usual stimulation compared with usual stimulation alone was considered in people with long-standing aphasia using data from the CACTUS trial. A model-based approach was taken. Where possible the input parameters required for the model were obtained from the CACTUS trial data, a United Kingdom-based pilot randomized controlled trial that recruited thirty-four people with aphasia and randomized them to computer treatment or usual care. Cost-effectiveness was described using an incremental cost-effectiveness ratio (ICER) together with cost-effectiveness acceptability curves. A value of information analysis was undertaken to inform future research priorities.
  
  
  RESULTS
  The intervention had an ICER of £3,058 compared with usual care. The likelihood of the intervention being cost-effective was 75.8 percent at a cost-effectiveness threshold of £20,000 per QALY gained. The expected value of perfect information was £37 million.
  
  
  CONCLUSIONS
  Our results suggest that computer therapy for people with long-standing aphasia is likely to represent a cost-effective use of resources. However, our analysis is exploratory given the small size of the trial it is based upon and therefore our results are uncertain. Further research would be of high value, particularly with respect to the quality of life gain achieved by people who respond well to therapy.
authors.affiliation: School of Health and Related Research, University of Sheffield.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Latimer
authors.forename: Simon
authors.initials: S
authors.lastname: Dixon
authors.forename: Rebecca
authors.initials: R
authors.lastname: Palmer
mesh_terms: D001037:Aphasia / Q000209:etiology / Q000628:therapy*; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis / Q000379:methods; D006801:Humans; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012648:Self Care; D020521:Stroke / Q000150:complications*; D011795:Surveys and Questionnaires; D013813:Therapy, Computer-Assisted / Q000191:economics*