title: Markers for detection of prostate cancer.
abstract: Early detection of prostate cancer is problematic, not just because of uncertainly whether a diagnosis will benefit an individual patient, but also as a result of the imprecise and invasive nature of establishing a diagnosis by biopsy. Despite its low sensitivity and specificity for identifying patients harbouring prostate cancer, serum prostate specific antigen (PSA) has become established as the most reliable and widely-used diagnostic marker for this condition. In its wake, many other markers have been described and evaluated. This review focuses on the supporting evidence for the most prominent of these for detection and also for predicting outcome in prostate cancer.
authors.affiliation: Prostate Cancer Institute, Cancer Care Centre, St George Hospital Clinical School of Medicine, University of New South Wales, Kogarah, NSW 2217, Australia. f.gardiner@uq.edu.au.
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Clarke
authors.forename: Horst J
authors.initials: HJ
authors.lastname: Schirra
authors.forename: James W
authors.initials: JW
authors.lastname: Catto
authors.forename: Martin F
authors.initials: MF
authors.lastname: Lavin
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gardiner