title: Recent advances in our understanding of insulin signalling to the podocyte.
abstract: It is becoming increasingly clear that the insulin responses of a number of different cell types within the kidney are important in the maintenance of normal renal function. This review summarizes our current understanding of renal insulin signalling, with specific focus on the podocyte, presenting recent evidence that suggests these responses are altered in systemic insulin-resistant states and chronic kidney disease via a number of different mechanisms.
authors.affiliation: Academic Renal Unit, Learning and Research Building, Southmead Hospital, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK.
authors.forename: Abigail
authors.initials: A
authors.lastname: Lay
authors.affiliation: Academic Renal Unit, Learning and Research Building, Southmead Hospital, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Coward
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007249:Inflammation / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D007668:Kidney / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology; D050199:Podocytes / Q000378:metabolism / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007328:Insulin; D051057:Proto-Oncogene Proteins c-akt
keywords: AKT; diabetic nephropathy; insulin; podocyte