title: Plasma long-chain free fatty acids predict mammalian longevity.
abstract: Membrane lipid composition is an important correlate of the rate of aging of animals and, therefore, the determination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations, peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity.
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (IRBLleida), E-25198 Lleida, Spain.
authors.forename: Mariona
authors.initials: M
authors.lastname: Jové
authors.forename: Alba
authors.initials: A
authors.lastname: Naudí
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Aledo
authors.forename: Rosanna
authors.initials: R
authors.lastname: Cabré
authors.forename: Victoria
authors.initials: V
authors.lastname: Ayala
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otin
authors.forename: Gustavo
authors.initials: G
authors.lastname: Barja
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
mesh_terms: D000375:Aging / Q000097:blood*; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D015227:Lipid Peroxidation; D008136:Longevity / Q000502:physiology*; D008322:Mammals / Q000097:blood; D008563:Membrane Lipids / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D005230:Fatty Acids, Nonesterified; D008563:Membrane Lipids