title: Statin intolerance: more questions than answers.
abstract: The dramatic effectiveness of statins in improving the course of atherosclerotic cardiovascular disease tends to overshadow questions of statin intolerance. Thus after more than 25 years of clinical statin use, intolerance remains a poorly understood, frustrating issue for patients and providers. It has been extraordinarily difficult to define statin intolerance and its implications for clinical practice. Here, we briefly summarize current knowledge and raise questions that need to be addressed.
authors.affiliation: Department of Medicine, Duke University Medical Center, Division of Endocrinology, Metabolism and Nutrition, Durham, NC 27710, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Guyton
authors.forename: Kristen B
authors.initials: KB
authors.lastname: Campbell
authors.forename: Wanda C
authors.initials: WC
authors.lastname: Lakey
mesh_terms: D050197:Atherosclerosis / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors