title: Gene regulation: when analog beats digital.
abstract: Why do some genes seem to respond in a 'digital', on/off manner to a graded signal, while others produce an 'analog', graded response? A new study suggests that the DNA-binding properties of transcription factors can strongly influence the response patterns of gene networks.
authors.affiliation: Department of Cell and Developmental Biology and Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Lorberbaum
authors.forename: Scott
authors.initials: S
authors.lastname: Barolo
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000196:embryology* / Q000254:growth & development; D005786:Gene Expression Regulation; D011485:Protein Binding; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors