title: New insights into the pathogenesis of cystic fibrosis sinusitis.
abstract: BACKGROUND
  People with cystic fibrosis (CF) sinus disease have developmental sinus abnormalities with airway bacterial infection, inflammation, impaired mucociliary clearance and thick obstructive mucus. The pathophysiology of airway disease in CF is not completely understood, and current treatments in CF sinus disease ameliorate symptoms but do not provide a cure.
  
  
  METHODS
  This manuscript reviews the history of CF, its manifestations in sinus disease, and the potential impact and relationship of CF on the upper and lower airway.
  
  
  RESULTS
  There is increasing evidence that CF sinus disease may affect CF lung disease, the most common cause of mortality in CF. We have been limited in treating the symptoms of advanced CF sinus disease with our current therapies.
  
  
  CONCLUSIONS
  Recent discoveries in the pathophysiology of CF using the CF porcine animal model and exciting treatments that address the primary gene defect that may translate into improved outcomes in CF and non-CF sinusitis in humans.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.
authors.forename: Eugene H
authors.initials: EH
authors.lastname: Chang
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D001424:Bacterial Infections / Q000150:complications* / Q000235:genetics / Q000276:immunology; D003550:Cystic Fibrosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D004195:Disease Models, Animal; D055724:Electrophysiological Phenomena; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology* / Q000382:microbiology; D010256:Paranasal Sinuses / Q000276:immunology* / Q000382:microbiology; D012137:Respiratory System / Q000276:immunology* / Q000382:microbiology; D012852:Sinusitis / Q000209:etiology* / Q000235:genetics / Q000276:immunology
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: CFTR; airway biology; electrophysiology; gene therapy; ion transport