title: Impact of kidney donor hemostasis on risk of complications after transplantation--preliminary outcomes.
abstract: BACKGROUND
  This study analyzes the influence the of kidney donor hemostasis on the risk of complications in the kidney recipient after transplantation.
  
  
  METHODS
  We enrolled 38 deceased kidney donors, of whom 14 donors died from a physical injury and the others died from ischemic or bleeding central nervous system stroke. The donors were categorized into 2 subgroups. If the recipient's postoperative period proceeded smoothly, the kidney donor was assigned to the uncomplicated donors (UD) group. If the recipient's postoperative period was complicated, the donor was assigned to the complicated (CD) Group. The CD group of consisted of 9 donors who died from strokes or bleedings and 2 who died from physical injury. We examined the antithrombin (AT) protein C (PC), complexes of thrombin/antithrombin (TAT), fragments F1+2 of prothrombin (F1+2), plasminogen (Pl), complexes of plasmin/antiplasmin (PAP), and D-dimers (D-d).
  
  
  RESULTS
  In the CD group had decreased activity of AT, PC, and Pl and increased activity of F1+2, TAT, and D-d. The UD group had a higher level of PAP. The CD group had evidence of intensive blood coagulation, but the UD group had evidence of fibrinolysis. Fisher's exact test revealed an increased risk in recipients who received a kidney from the CD group.
  
  
  CONCLUSIONS
  The hemostasis of the kidney donors had a correlation with the occurrence of some complications in the kidney recipients, especially complications connected with activation of blood coagulation. It seems that the activation of fibrinolysis could be positive prognostic factor, but this requires further investigations.
authors.affiliation: Independent Laboratory of Aesthetic Dermatology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: Iza
authors.initials: I
authors.lastname: Iwan-Ziętek
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Ziętek
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Sulikowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: Marek
authors.initials: M
authors.lastname: Ostrowski
authors.forename: Danuta
authors.initials: D
authors.lastname: Rość
authors.forename: Marek
authors.initials: M
authors.lastname: Kamiński
mesh_terms: D058833:Antithrombin Proteins / Q000378:metabolism; D002102:Cadaver; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D010958:Plasminogen / Q000378:metabolism; D011044:Poland; D011183:Postoperative Complications / Q000209:etiology*; D011486:Protein C / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D051437:Renal Insufficiency / Q000601:surgery*; D018709:Statistics, Nonparametric; D014019:Tissue Donors
chemical_list: D058833:Antithrombin Proteins; D011486:Protein C; D011516:Prothrombin; D010958:Plasminogen