title: Quality of life, pulmonary spirometry, and dosage of steroid in asthmatic patients with polyposis after endoscopic sinus surgery.
abstract: BACKGROUND
  The association between asthma and sinonasal disease has been established for years. As sinonasal disease is one of the factors that exacerbates asthma, effective treatment of this disorder may also improve and stabilize the asthmatic condition. This study examines the outcome of endoscopic sinus surgery (ESS) on asthmatic patients with massive nasal polyposis.
  
  
  METHODS
  Forty-five asthmatic patients were included in the study. All were operated on and analyzed in our department. A questionnaire (SNOT-20) investigating the subjective evaluation of asthma and sinonasal states was presented to the patients, while objective evaluations including nasal rhinoscopy, forced expiratory volume in 1 second (FEV1), and steroid use were conducted with 1-2 years of follow up.
  
  
  RESULTS
  Quality of life (QoL) improved in 97.8% of patients, while clinical symptoms, emotional signs, and social signs improved in 97.7%, 84.4%, and 93.3%, respectively. Medication use for asthma showed a similar improvement, with approximately 80% of patients reducing and 75.6% of patients discontinuing steroid use. A total of 91.1% of patients showed improvement in post-operative FEV1.
  
  
  CONCLUSIONS
  ESS achieved a beneficial effect on sinonasal and asthma symptomatology in patients with nasal polyps and asthma. QoL was also improved in these patients.
authors.affiliation: Department of Otorhinolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.forename: Behrooz
authors.initials: B
authors.lastname: Gandomi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tarzi
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Yeganeh
keywords: Asthma; Endoscopy; FEV1; Polyp; Quality of Life