title: Impaired colour discrimination in Huntington's disease.
abstract: Colour discrimination and visual contrast perception were investigated in 18 patients with Huntington's disease (HD) and in 18 age- and sex-matched healthy volunteers using the Farnsworth-Munsell 100 Hue test (FM) and stationary contrast targets. The mean total error score (MTES) and the partial scores for the "red-green" and the "blue-yellow" axes in the FM of the patients with HD were significantly elevated as compared to controls (MTES in HD: 113.0 ± 90.8; MTES in controls: 19.2 ± 8.8). The spatial contrast sensitivity in HD patients was normal. The colour perception dysfunction indicates that the visual system is affected in HD. The visual disorder may be related to an imbalance of certain neurotransmitters in the visual system of HD patients. Possible anatomical sites of the dysfunction responsible for colour discrimination abnormalities could be the retinal cone system and/or impaired parvocellular central visual pathways in HD.
authors.affiliation: Department of Neurology, Ruhr-University Bochum, St.-Josef-Hospital, Bochum, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Büttner
authors.forename: S
authors.initials: S
authors.lastname: Schulz
authors.forename: W
authors.initials: W
authors.lastname: Kuhn
authors.forename: A
authors.initials: A
authors.lastname: Blumenschein
authors.forename: H
authors.initials: H
authors.lastname: Przuntek