title: An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer.
abstract: Adiponectin (ADIPOQ) is a cytokine produced by adipose tissue involved in carcinogenesis. ADIPOQ SNP rs2241766 has been extensively studied in colorectal cancer (CRC) community with contentious and conflicting conclusions. The objective of this study was to comprehensively assess the association between SNP rs2241766 and CRC risk. PubMed, Embase, CNKI, as well as the references of the retrieved articles were searched to identify the eligible studies for this meta-analysis. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the association. We also examined the heterogeneity and publication bias and performed sensitivity analyses. Seven studies with 2,414 cases and 2,796 controls together did not show any significant association between SNP rs2241766 and CRC risk. Subgroup analyses by ethnicity and sample size also failed to provide statistically significant evidence. This meta-analysis demonstrates that ADIPOQ SNP rs2241766 may not represent as an effect modifier for the risk of CRC.
authors.affiliation: Department of Oncology Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Hongyi
authors.initials: H
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Kong
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Baoqing
authors.initials: B
authors.lastname: Jia
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin