title: Kidney allograft survival of African American and Caucasian American recipients with lupus.
abstract: BACKGROUND
  African Americans with lupus who receive kidney transplants have high prevalence of predictors of allograft failure, which can explain their poor outcomes.
  
  
  METHODS
  Of 1223 African Americans and 1029 Caucasian Americans with lupus who received kidney transplants from deceased donors between 1987 and 2006 with complete records in the UNOS program, 741 pairs were matched in 16 predictors employing a predicted probability of group membership. The primary outcome was allograft failure. Main secondary outcomes were rejection, allograft failure due to rejection, and mortality.
  
  
  RESULTS
  Matched pairs were predominantly women (82%) with a mean age of 39 years. Twenty-four percent of recipients received kidneys from expanded criteria donors. African Americans and Caucasian Americans matched well (p ≥ 0.05): donor age, gender and race; recipient age, gender, education and insurance; dialysis prior to transplant, kidneys from expanded criteria donors, cold ischemia time, history of prior kidney transplant, panel reactive antibodies, human leukocyte antigens mismatch, blood type compatibility, transplant Era, and follow-up time. Contrary to the unmatched cohort with significantly higher allograft failure rate (events per 100 patient-years) in African Americans compared to Caucasian Americans (10.49 vs 6.18, p<0.001), matched pairs had similar allograft failure rates (8.41 vs 7.81, p=0.418). Matched pairs also had similar rates of rejections (9.82 vs 9.39, p=0.602), allograft failure due to rejection (6.19 vs 5.71, p=0.453), and mortality (2.79 vs 3.52, p=0.097).
  
  
  CONCLUSIONS
  In lupus recipients of kidney transplants from deceased donors, African American and Caucasian Americans have similar allograft failure rates when predictors are matched between groups.
authors.affiliation: 1Division of Nephrology and Hypertension Department of Medicine.
authors.forename: G
authors.initials: G
authors.lastname: Contreras
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez-Suarez
authors.forename: T
authors.initials: T
authors.lastname: Isakova
authors.forename: J J
authors.initials: JJ
authors.lastname: Scialla
authors.forename: F
authors.initials: F
authors.lastname: Pedraza
authors.forename: A
authors.initials: A
authors.lastname: Mattiazzi
authors.forename: R
authors.initials: R
authors.lastname: Diaz-Wong
authors.forename: J
authors.initials: J
authors.lastname: Sageshima
authors.forename: Y
authors.initials: Y
authors.lastname: Brito
authors.forename: G
authors.initials: G
authors.lastname: Guerra
authors.forename: B
authors.initials: B
authors.lastname: Acevedo
authors.forename: A
authors.initials: A
authors.lastname: Sajid Ali
authors.forename: T J
authors.initials: TJ
authors.lastname: Kershaw
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: G W
authors.initials: GW
authors.lastname: Burke
authors.forename: W
authors.initials: W
authors.lastname: Kupin
authors.forename: G
authors.initials: G
authors.lastname: Ciancio
authors.forename: D
authors.initials: D
authors.lastname: Roth
mesh_terms: D000328:Adult; D001741:Black or African American; D064591:Allografts; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects; D008181:Lupus Nephritis / Q000150:complications / Q000601:surgery*; D008297:Male; D014019:Tissue Donors; D014481:United States; D044465:White People
keywords: Nephritis; renal lupus; systemic lupus erythematosus