title: Skin involvement in atypical hemolytic uremic syndrome.
abstract: Skin involvement in atypical hemolytic uremic syndrome (aHUS) is very uncommon and therefore often unrecognized as a specific symptom of aHUS. We describe 3 cases of patients with aHUS who developed skin lesions that completely recovered when disease-specific treatment was established. These cases suggest that in individuals with aHUS, when skin lesions of unknown origin occur, the possibility that they are due to thrombotic microangiopathy should be considered.
authors.affiliation: Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: ardissino@centroseu.org.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Ardissino
authors.affiliation: Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Tel
authors.affiliation: Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Testa
authors.affiliation: Dermatology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Angelo Valerio
authors.initials: AV
authors.lastname: Marzano
authors.affiliation: Dermatology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Lazzari
authors.affiliation: Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Salardi
authors.affiliation: Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Edefonti
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D065766:Atypical Hemolytic Uremic Syndrome; D017242:Complement Factor H; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D010951:Plasma Exchange; D012867:Skin / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D017242:Complement Factor H; C481642:eculizumab
keywords: Haemolytic uremic syndrome; case report; eculizumab; plasma exchange; skin; thrombotic microangiopathy