title: Early outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a European multicenter and multinational study.
abstract: BACKGROUND
  This study was designed to evaluate the outcomes of alcohol septal ablation (ASA) under multicenter and multinational conditions.
  
  
  METHODS
  Data for 459 patients (age 57 ± 13 years) from nine European centers were prospectively collected and retrospectively analyzed.
  
  
  RESULTS
  ASA led to a significant reduction in outflow gradient (PG) and dyspnea [median of PG from 88 (58-123) mm Hg to 21 (11-41) mm Hg; median of NYHA class from 3 (2-3) to 1 (1-2); P < 0.01]. The incidence of 3-month major adverse events (death, electrical cardioversion for tachyarrhythmias, resuscitation) and mortality was 2.8% and 0.7%, respectively. Permanent pacemakers for post-ASA complete heart block were implanted in 43 patients (9%). Multivariate analysis identified higher amount of alcohol (however, in generally low-dose procedures), higher baseline left ventricular ejection fraction and higher age as independent predictors of PG decrease ≥50%.
  
  
  CONCLUSIONS
  The results of the first European multicenter and multinational study demonstrate that real-world early outcomes of ASA patients are better than was reported in observations from the first decade after ASA introduction.
authors.affiliation: Department of Cardiology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Veselka
authors.forename: Thorsten
authors.initials: T
authors.lastname: Lawrenz
authors.forename: Christoph
authors.initials: C
authors.lastname: Stellbrink
authors.forename: David
authors.initials: D
authors.lastname: Zemanek
authors.forename: Marian
authors.initials: M
authors.lastname: Branny
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Januska
authors.forename: Jan
authors.initials: J
authors.lastname: Sitar
authors.forename: Pawel
authors.initials: P
authors.lastname: Dimitrow
authors.forename: Jan
authors.initials: J
authors.lastname: Krejci
authors.forename: Maciej
authors.initials: M
authors.lastname: Dabrowski
authors.forename: Stanislav
authors.initials: S
authors.lastname: Mizera
authors.forename: Thomas
authors.initials: T
authors.lastname: Bartel
authors.forename: Horst
authors.initials: H
authors.lastname: Kuhn
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002312:Cardiomyopathy, Hypertrophic / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D000431:Ethanol / Q000494:pharmacology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult
chemical_list: D000431:Ethanol
keywords: alcohol septal ablation; cardiomyopathy; hypertrophic cardiomyopathy