title: Histophysiology of the immune system of Wistar rats at delayed terms after ovariectomy.
abstract: We studied histophysiological changes in organs of the immune system, liver, and lungs of Wistar rats at delayed terms after ovariectomy. On day 52 after surgical castration leading to a decrease in estradiol, progesterone, and testosterone levels, activation of the immune system was revealed characterized by stage I accidental thymus involution, while pulp depletion in the spleen, and enhanced IL-2 and IFN-γ production. We also observed small-droplet degeneration of hepatocytes and reactive changes in the lungs manifested in increased number of neutrophils in the interalveolar septa.
authors.affiliation: Laboratory of Immunomorphology of Inflammation, Institute Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. morfolhum@mail.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Kosyreva
authors.forename: E Yu
authors.initials: EY
authors.lastname: Simonova
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D022781:Hepatocytes / Q000276:immunology* / Q000473:pathology; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008099:Liver / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D010052:Ovariectomy; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood; D013950:Thymus Gland / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007371:Interferon-gamma; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase