title: How can we bring high drug doses to the lung?
abstract: In the last decades, dry powder inhalation has become a very attractive option for pulmonary drug delivery to treat lung diseases like cystic fibroses and lung infections. In contrast to the traditional pulmonary application of drugs for asthma and chronic obstructive pulmonary disease, these therapies require higher lung doses to be administered. The developments and improvements toward high dose powder pulmonary drug delivery are summarized and discussed in this chapter. These include the invention and improvement of novel inhaler devices as well as the further development of formulation principles and new powder engineering methods. The implementation of these strategies is subsequently described for some prototypes and formulations in research and development stage as well as for already marketed dry powder products. Finally, possible adverse effects that can occur after inhalation of high powder doses are shortly addressed.
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Claus
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany.
authors.forename: Claudius
authors.initials: C
authors.lastname: Weiler
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Schiewe
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany. Electronic address: wolfgang.friess@lrz.uni-muenchen.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Friess
mesh_terms: D000280:Administration, Inhalation; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D058995:Dry Powder Inhalers; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D036501:Metered Dose Inhalers; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations
keywords: Antibiotic inhalation; Dry powder inhalation; High dose delivery; Inhalation devices; Lung delivery; Particle engineering; Pulmonary drug delivery