title: Total synthesis of (±)-sculponeatin N.
abstract: The first total synthesis of the (±)-sculponeatin N (a 6,7-seco-ent-kaurane diterpenoid discovered by Sun and co-workers) has been achieved. The features include a regio- and stereoselective aldol reaction to form a lactone, an intramolecular Diels-Alder reaction to install B and C rings simultaneously, and a radical cyclization to forge the D ring.
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Pan
authors.forename: Cunying
authors.initials: C
authors.lastname: Zheng
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.forename: Yanhe
authors.initials: Y
authors.lastname: Chen
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhai
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013729:Terpenes; C540959:sculponeatin N