title: [Cardiac reserve in Parkinson's disease and exercise therapy].
abstract: The clinical feature of Parkinson's disease (PD) is not based on the identification of the extrapyramidal symptom such as bradykinesia, restinbg tremor, rigidity, but also other non-motor symptom (REM sleep disorder, autonomic dysfunction, hyposmia etc). According to the cardio-sympathetic dysfunction, it is well known abnormal MIBG and orthostatic hypotension finding was seen in early disease stage. Furthermore denervation supersensitivity using β1 stimulant correlates the severity of MIBG image, so that this abnormal cardiac function induces inadequate cardiac capacity for exercise. Inadequate cardiac capacity makes easy fatigability, which correlates the abnormal MIBG image and cardio-sympathetic damage. So it is difficult to prescribe a specific exercise program to meet individual PD patients needs. Music therapy and trunk exercise (for example Tai-Chi exercise) are better suited for PD patients.
authors.affiliation: Department of Medical Laboratory Sciences, Nagoya University Graduate School of Medicine.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirayama
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D058665:Adrenergic beta-1 Receptor Agonists; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D004280:Dobutamine; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005221:Fatigue; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation / Q000628:therapy*; D011712:Pyramidal Tracts / Q000503:physiopathology; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D058665:Adrenergic beta-1 Receptor Agonists; D004280:Dobutamine