title: An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae.
abstract: Although oxalic acid is common in nature our understanding of the mechanism(s) regulating its turnover remains incomplete. In this study we identify Saccharomyces cerevisiae acyl-activating enzyme 3 (ScAAE3) as an enzyme capable of catalyzing the conversion of oxalate to oxalyl-CoA. Based on our findings we propose that ScAAE3 catalyzes the first step in a novel pathway of oxalate degradation to protect the cell against the harmful effects of oxalate derived from an endogenous process or an environmental source.
authors.affiliation: USDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030-2600, United States.
authors.forename: Justin
authors.initials: J
authors.lastname: Foster
authors.affiliation: USDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030-2600, United States. Electronic address: pnakata@bcm.edu.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nakata
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D003066:Coenzyme A Ligases / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D015966:Gene Expression Regulation, Fungal; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008954:Models, Biological; D009154:Mutation; D010070:Oxalates / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000214:Acyl Coenzyme A; D010070:Oxalates; D029701:Saccharomyces cerevisiae Proteins; C523110:oxalyl-coenzyme A; D002245:Carbon Dioxide; D003066:Coenzyme A Ligases; C586634:oxalyl-CoA synthetase, S cerevisiae
keywords: Acyl-activating; Degradation; Oxalate; Oxalyl-CoA