title: Photoresponsive vesicle permeability based on intramolecular host-guest inclusion.
abstract: This article describes light-responsive vesicles that can release their contents in response to a light-sensitive molecular trigger. To this end, liposomes were equipped with amphiphilic β-cyclodextrin that was covalently labeled with azobenzene. Using dye encapsulation and confocal laser scanning microscopy, we show that the permeability of these vesicles strongly increases upon UV irradiation (λ = 350 nm) with concomitant isomerization of apolar trans-azobenzene to polar cis-azobenzene on the liposome surface.
authors.affiliation: Organic Chemistry Institute and Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany. b.j.ravoo@uni-muenster.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Kauscher
authors.forename: Avik
authors.initials: A
authors.lastname: Samanta
authors.forename: Bart Jan
authors.initials: BJ
authors.lastname: Ravoo
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010316:Particle Size; D055668:Photochemical Processes; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D014466:Ultraviolet Rays; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D008081:Liposomes; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; C009850:azobenzene; C031215:betadex