title: Prodromal posterior cortical atrophy: clinical, neuropsychological, and radiological correlation.
abstract: We present longitudinal clinical, cognitive, and neuroimaging data from a 63-year-old woman who enrolled in research as a normal control and evolved posterior cortical atrophy (PCA) over 5 year follow-up. At baseline she reported only subtle difficulty driving and performed normally on cognitive tests, but already demonstrated atrophy in left visual association cortex. With follow-up she developed insidiously progressive visuospatial and visuoperceptual deficits, correlating with progressive atrophy in bilateral visual areas. Amyloid PET was positive. This case tracks the evolution of PCA from the prodromal stage, and illustrates challenges to early diagnosis as well as the utility of imaging biomarkers.
authors.affiliation: a Memory and Aging Center, Department of Neurology , University of California San Francisco , San Francisco , USA.
authors.forename: Lung Tat Andrew
authors.initials: LT
authors.lastname: Chan
authors.forename: Whitney
authors.initials: W
authors.lastname: Lynch
authors.forename: Mary
authors.initials: M
authors.lastname: De May
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Horton
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Gil D
authors.initials: GD
authors.lastname: Rabinovici
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001284:Atrophy / Q000150:complications / Q000175:diagnosis; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology; D049268:Positron-Emission Tomography; D062706:Prodromal Symptoms
keywords: PET; VBM; atypical Alzheimer's disease; neuropsychology; posterior cortical atrophy