title: Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate.
abstract: OBJECTIVE
  To evaluate the influence of age on the relationships between biochemical and hematological variables and stability of erythrocyte membrane in relation to the sodium dodecyl sulfate (SDS) in population of 105 female volunteers between 20 and 90 years.
  
  
  METHODS
  The stability of RBC membrane was determined by non-linear regression of the dependency of the absorbance of hemoglobin released as a function of SDS concentration, represented by the half-transition point of the curve (D50) and the variation in the concentration of the detergent to promote lysis (dD).
  
  
  RESULTS
  There was an age-dependent increase in the membrane stability in relation to SDS. Analyses by multiple linear regression showed that this stability increase is significantly related to the hematological variable red cell distribution width (RDW) and the biochemical variables blood albumin and cholesterol.
  
  
  CONCLUSIONS
  The positive association between erythrocyte stability and RDW may reflect one possible mechanism involved in the clinical meaning of this hematological index.
authors.forename: Mariana V
authors.initials: MV
authors.lastname: de Freitas
authors.forename: Liandra F
authors.initials: LF
authors.lastname: Marquez-Bernardes
authors.forename: Letícia R
authors.initials: LR
authors.lastname: de Arvelos
authors.forename: Lara F
authors.initials: LF
authors.lastname: Paraíso
authors.forename: Ana Flávia M
authors.initials: AF
authors.lastname: Gonçalves E Oliveira
authors.forename: Rita de C
authors.initials: Rde C
authors.lastname: Mascarenhas Netto
authors.forename: Morun Bernardino
authors.initials: MB
authors.lastname: Neto
authors.forename: Mario S
authors.initials: MS
authors.lastname: Garrote-Filho
authors.forename: Paulo César A
authors.initials: PC
authors.lastname: de Souza
authors.forename: Nilson
authors.initials: N
authors.lastname: Penha-Silva
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004909:Erythrocyte Indices / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D012709:Serum Albumin / Q000032:analysis; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D013053:Spectrophotometry; D013501:Surface-Active Agents / Q000494:pharmacology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D008055:Lipids; D012709:Serum Albumin; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate
keywords: Aging; Albumin; Erythrocyte; Membrane; RDW