title: [Pregnancy and delivery in women with multiple sclerosis: a retrospective analysis].
abstract: We have analyzed the course of multiple sclerosis (MS) in 155 pregnant women. In 85.7% cases, pregnancy resulted in delivery and in 14.3% cases - in abortion. Patients presented with relapse very shortly after the abortion and received hormonal treatment. Patients treated with disease-modifying drugs (DMD) did not have relapses during pregnancy compared to those who did not receive DMD before the pregnancy. In the latter group, 33 (40.2%) patients presented with relapses during the I trimester. After the delivery, the relapses were noted in 31 (27.2%) patients during the first year. The maximal number of relapses was recorded to the 3rd month after the delivery (58.1%) with the gradual reduction to the end of the year (6th month - 29% and 12th month - 12.9%). Patients who did not receive DMD had more relapses to the 3rd and 6th months after delivery. In conclusion, the use of DMD before the pregnancy is an important factor for prevention of relapses during pregnancy and after delivery.
authors.forename: E V
authors.initials: EV
authors.lastname: Popova
authors.forename: T M
authors.initials: TM
authors.lastname: Kukel'
authors.forename: A I
authors.initials: AI
authors.lastname: Muravin
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
authors.forename: A V
authors.initials: AV
authors.lastname: Murashko
authors.forename: E I
authors.initials: EI
authors.lastname: Gusev
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D009103:Multiple Sclerosis / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D055815:Young Adult