title: No Association between Tumor Necrosis Factor-alpha Gene Polymorphisms and Lung Cancer Risk.
abstract: OBJECTIVE
  The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-α) for lung cancer development was evaluated.
  
  
  METHODS
  Genotypes of the TNF-α polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls.
  
  
  RESULTS
  After adjusting for body mass index and smoking, each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p>0.05).
  
  
  CONCLUSIONS
  This study found no association between common variants of the TNF-α gene and lung cancer risk.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
keywords: Lung cancer risk; Polymorphism; Tumor necrosis factor-alpha