title: Diastereoselective synthesis of epoxide-fused benzoquinolizidine derivatives using intramolecular domino aza-Michael addition/Darzens reaction.
abstract: An efficient and diastereoselective strategy based on an intramolecular domino aza-Michael/Darzens reaction to synthesize epoxide-fused benzoquinolizidines has been described. Three bonds (1 C-C, 1 C-N and 1 C-O), three rings and three chiral centers can be constructed in a single pot under very mild conditions. All the products were isolated in only one diastereomer with 40-80% yields.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. yushouyun@nju.edu.cn.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Guo
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Sun
authors.forename: Shouyun
authors.initials: S
authors.lastname: Yu
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D054837:Quinolizidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D054837:Quinolizidines