title: Age-related peculiarities of inotropic response of rat myocardium to selective block of M1-cholinoreceptors.
abstract: In vitro effect of M1-cholinoreceptor blockade on the cardiac inotropic function was examined in rats aging 1, 3, 6, 8, and 20 weeks. In 1- and 3-week old rat pups, the sympathetic control of the heart has not developed, the age of 7-8 weeks being pubertal. Adult 20-week rats were used as the controls. In rats of all age groups, preliminary blockade of M1-cholinoreceptors did not prevent the inhibitory effect of carbacholine on contractility of the atrial and ventricular myocardium. The inhibitory effect of pirenzepine on the contractile force of ventricular myocardium was revealed in 6-week rats.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Volga Riverside Federal University; Department of Normal Physiology, Kazan Federal Medical University, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003864:Depression, Chemical; D006325:Heart Atria / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010890:Pirenzepine / Q000494:pharmacology*; D051381:Rats; D043643:Receptor, Muscarinic M1 / Q000037:antagonists & inhibitors*
chemical_list: D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D043643:Receptor, Muscarinic M1; D010890:Pirenzepine; D002217:Carbachol