title: Isotretinoin and mental health in adolescents: Australian consensus.
abstract: Acne is a common condition among adolescents and has the potential to negatively impact on the psychological well-being of those who suffer from it. In particular, depression and suicidal ideation are more common in adolescents with acne. Successful treatment of acne can improve the quality of life and reduce levels of anxiety and depression in these individuals. The current treatment of choice for severe or refractive acne is isotretinoin, a retinoid. While the possible causal association between isotretinoin and mental illness remains a controversial topic, a recent systematic review has presented evidence to support this relationship. In light of this evidence, a group of dermatologists and psychiatrists have collaborated to develop these recommendations to aid the safe prescribing of isotretinoin in adolescents. These clinical suggestions are aimed at practitioners in both disciplines to increase awareness of the current evidence in support of the association between isotretinoin and adolescent depression.
authors.affiliation: University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
authors.forename: Casey
authors.initials: C
authors.lastname: Rowe
authors.forename: Lynda
authors.initials: L
authors.lastname: Spelman
authors.forename: Margaret
authors.initials: M
authors.lastname: Oziemski
authors.forename: Alexander
authors.initials: A
authors.lastname: Ryan
authors.forename: Shobhan
authors.initials: S
authors.lastname: Manoharan
authors.forename: Perry
authors.initials: P
authors.lastname: Wilson
authors.forename: Michael
authors.initials: M
authors.lastname: Daubney
authors.forename: James
authors.initials: J
authors.lastname: Scott
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D001315:Australia; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D001523:Mental Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D018579:Patient Selection; D011788:Quality of Life
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: adolescent; depression; guideline; isotretinoin; suicide