title: The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression.
abstract: The SeDeM diagram expert system has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril direct compression SR matrix tablets. The application of the SeDeM diagram expert system enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM diagram expert system as system responses.
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Saurí
authors.affiliation: Lab. Kern Pharma, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Millán
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain; IDIBELL-UB Research Group: Pharmacotherapy, Pharmacogenomics & Pharmaceutical Technology, Barcelona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Suñé-Negre
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain; IDIBELL-UB Research Group: Pharmacotherapy, Pharmacogenomics & Pharmaceutical Technology, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Lozano
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Sarrate
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fàbregas
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Carrillo
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain; IDIBELL-UB Research Group: Pharmacotherapy, Pharmacogenomics & Pharmaceutical Technology, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Miñarro
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain; IDIBELL-UB Research Group: Pharmacotherapy, Pharmacogenomics & Pharmaceutical Technology, Barcelona, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Ticó
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, Universitat de Barcelona, Barcelona, Spain; IDIBELL-UB Research Group: Pharmacotherapy, Pharmacogenomics & Pharmaceutical Technology, Barcelona, Spain. Electronic address: encarnagarcia@ub.edu.
authors.forename: E
authors.initials: E
authors.lastname: García-Montoya
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D002216:Captopril / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry*; D005103:Expert Systems; D011312:Pressure; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D002216:Captopril
keywords: Captopril; Diagram expert system; Direct compression; Index good compression (IGC); Preformulation; Quality by Design (ICH Q8); SeDeM; Slow release