title: Nondestructive analysis of structure and components of tablet coated with film by the usage of terahertz time-domain reflection spectroscopy.
abstract: Nondestructive analysis of tablet is of great importance from the aspect of productivity and safety. In terahertz (THz) region, however, the analysis of core of coated tablet has not been progressed. In this study, we have measured a flat-surface push-pull osmotic pump tablet, having no orifice, having bilayer core and a coating film layer. The bilayer core was made from the drug layer and the push layer, and acetaminophen was contained in the drug layer as a model drug. To study its structure and components, we have obtained reflection spectra from the drug layer side and the push layer side measurements using THz time-domain reflection spectroscopy (THz-TDRS). From these results, detection of the peak of acetaminophen in the spectrum from the drug layer side measurements was confirmed. We have made ridges approximated toward the peak using a general method of linear regression analysis in both spectra. Two-sample t-test was applied to their gradients, and significant difference between the drug layer and the push layer was shown. These results suggested that THz-TDRS is applicable to the analysis of structure and component of a coated tablet.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, 278-8510, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Takeuchi
authors.forename: Kemmaro
authors.initials: K
authors.lastname: Shimakura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ohtake
authors.forename: Jun
authors.initials: J
authors.lastname: Takayanagi
authors.forename: Keishiro
authors.initials: K
authors.lastname: Tomoda
authors.forename: Takehisa
authors.initials: T
authors.lastname: Nakajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terada
authors.forename: Kimiko
authors.initials: K
authors.lastname: Makino
mesh_terms: D000082:Acetaminophen / Q000737:chemistry; D009995:Osmosis; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D055068:Terahertz Spectroscopy / Q000379:methods
chemical_list: D013607:Tablets; D000082:Acetaminophen
keywords: analysis; bilayer coated tablet; coating; nondestructive analysis of component; osmotic pumps; push-pull osmotic pump; spectroscopy; structure; terahertz time-domain reflection spectroscopy