title: Quality evaluation of Panax ginseng roots using a rapid resolution LC-QTOF/MS-based metabolomics approach.
abstract: Korean ginseng (Panax ginseng C.A. Meyer) contains several types of ginsenosides, which are considered the major active medicinal components of ginseng. The types and quantities of ginsenosides found in ginseng may differ, depending on the location of cultivation, making it necessary to establish a reliable method for distinguishing cultivation locations of ginseng roots. P. ginseng roots produced in different regions of Korea, China, and Japan have been unintentionally confused in herbal markets owing to their complicated plant sources. PCA and PLS-DA using RRLC-QTOF/MS data was able to differentiate between ginsengs cultivated in Korea, China, and Japan. The chemical markers accountable for such variations were identified through a PCA loadings plot, tentatively identified by RRLC-QTOF/MS and partially verified by available reference standards. The classification result can be used to identify P. ginseng origin.
authors.affiliation: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea. nibaek@khu.ac.kr.
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Jae Kwang
authors.initials: JK
authors.lastname: Kim
authors.forename: Sabina
authors.initials: S
authors.lastname: Shrestha
authors.forename: Kyeong-Hwa
authors.initials: KH
authors.lastname: Seo
authors.forename: Youn-Hyung
authors.initials: YH
authors.lastname: Lee
authors.forename: Hyung-Jun
authors.initials: HJ
authors.lastname: Noh
authors.forename: Geum-Soog
authors.initials: GS
authors.lastname: Kim
authors.forename: Yong-Bum
authors.initials: YB
authors.lastname: Kim
authors.forename: Seung-Yu
authors.initials: SY
authors.lastname: Kim
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D036145:Ginsenosides / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods; D008518:Medicine, East Asian Traditional / Q000592:standards*; D055432:Metabolomics / Q000379:methods; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D011786:Quality Control
chemical_list: D036145:Ginsenosides