title: Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia.
abstract: Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749 (Korea).
authors.forename: Dongwon
authors.initials: D
authors.lastname: Yoo
authors.forename: Heeyeong
authors.initials: H
authors.lastname: Jeong
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Noh
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008280:Magnetics / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D023041:Xenograft Model Antitumor Assays
chemical_list: D058185:Magnetite Nanoparticles
keywords: apoptotic hyperthermia; cancer; heat shock proteins; magnetic nanoparticles; thermoresistance