title: Higher carbohydrate antigen 125 levels are associated with increased risk of coronary heart disease in elderly chinese: a population-based case-control study.
abstract: BACKGROUND
  High carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease (CHD) risk remains unclear. The aim of this study was to explore the potential association in a Chinese older population.
  
  
  METHODS
  In a population-based case-control study conducted in a Chinese older population, serum CA-125 levels were measured in 1177 diagnosed CHD patients and 3531 age and sex matched control subjects without CHD.
  
  
  RESULTS
  Serum CA-125 level was significantly higher in CHD patients than controls (P < 0.001) with adjustment for age, gender, smoking, drinking, BMI, physical activity, hypertension, dyslipidemia, diabetes mellitus, medication history and family history of CHD and myocardial infarction. CHD risk was doubled (OR: 2.10, 95%CI: 1.69-2.60) among subjects in the highest quartile compared to those in the lowest quartile of CA-125 level (P trend < 0.001). Furthermore, CA-125 levels were associated with CHD risks in subjects with age over 60 years (OR: 2.19, 95%CI: 1.75-2.73), current smokers (OR: 2.29, 95%CI: 1.50-3.49), current drinkers (OR: 2.35, 95%CI: 1.57-3.53) and subjects with hypertension (OR: 2.04, 95%CI: 1.71-2.43).
  
  
  CONCLUSIONS
  Elevated serum CA-125 level might be associated with increased risk of coronary heart disease in the Chinese older population. Further investigations are needed to identify the possible biological role of CA-125 in CHD development in the future.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China ; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Li
authors.forename: Meian
authors.initials: M
authors.lastname: He
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Xiulou
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.forename: Xinwen
authors.initials: X
authors.lastname: Min
authors.forename: Mingjian
authors.initials: M
authors.lastname: Lang
authors.forename: Handong
authors.initials: H
authors.lastname: Yang
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D062486:Public Health Surveillance; D012306:Risk; D012720:Severity of Illness Index
chemical_list: D018394:CA-125 Antigen