title: Toxicological evaluation of Antrodia cinnamomea in BALB/c mice.
abstract: Antrodia cinnamomea is a natural component of some herbal medicines used for treatment of abdominal pain, hypertension and hepatocellular carcinoma in Taiwan and other countries. Subchronic oral toxicity studies of A. cinnamomea extracts in male and female BALB/c mice were performed to evaluate its safety. Three different concentrations of A. cinnamomea (16.67, 833.3 and 1666.67 mg/kg/day) were given orally to groups of mice (10 mice/dose) for 90 consecutive days. All animals survived to the end of the study, and there were no significant differences in body weight among the control and treatment groups. No significant differences were found in hematological and serum biochemical parameters among the control and treatment groups. No abnormalities of internal organs were observed in the treated groups.
authors.affiliation: Department of Biological Science and Technology, China Medical University, No 91, Hsueh-Shih Road, Taichung 404, Taiwan. jgchung@mail.cmu.edu.tw and Dr. Chuan-Hsun Chang, Department of Nutrition Therapy, Cheng-Hsin General Hospital, No. 45 Cheng Hsin Street, Taipei 112, Taiwan, R.O.C. E-mail: hsunfang@gmail.com.
authors.forename: Jin-Biou
authors.initials: JB
authors.lastname: Chang
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Wu
authors.forename: Hsu-Feng
authors.initials: HF
authors.lastname: Lu
authors.forename: Jason
authors.initials: J
authors.lastname: Chou
authors.forename: Man-Kuan
authors.initials: MK
authors.lastname: Au
authors.forename: Nien-Chieh
authors.initials: NC
authors.lastname: Liao
authors.forename: Chuan-Hsun
authors.initials: CH
authors.lastname: Chang
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Chin-Tung
authors.initials: CT
authors.lastname: Wu
authors.forename: Jing-Gung
authors.initials: JG
authors.lastname: Chung
mesh_terms: D000818:Animals; D055491:Antrodia / Q000737:chemistry*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D062610:Fungal Polysaccharides / Q000633:toxicity*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D062610:Fungal Polysaccharides
keywords: Antrodia cinnamomea; BALB/c mice; toxicity