title: T regulatory cells in childhood arthritis--novel insights.
abstract: In recent years, there have been many new developments in the field of regulatory T cells (Treg), challenging the consensus on their behaviour, classification and role(s) in disease. The role Treg might play in autoimmune disease appears to be more complex than previously thought. Here, we discuss the current knowledge of regulatory T cells through animal and human research and illustrate the recent developments in childhood autoimmune arthritis (juvenile idiopathic arthritis (JIA)). Furthermore, this review summarises our understanding of the fields and assesses current and future implications for Treg in the treatment of JIA.
authors.affiliation: Rheumatology Unit, UCL Institute of Child Health, University College London, London, UK.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Pesenacker
authors.forename: Lucy R
authors.initials: LR
authors.lastname: Wedderburn
mesh_terms: D000293:Adolescent; D019264:Adoptive Transfer; D000818:Animals; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D002648:Child; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines