title: Assessment of serum leptin and resistin levels in association with the metabolic risk factors of pre- and post-menopausal rural women in South India.
abstract: OBJECTIVE
  Menopausal status is related with weight gain, abnormal lipid and glucose metabolism leading to metabolic syndrome susceptibility. The aim of this study is to determine circulating serum leptin and resistin levels and to correlate these levels in relationship with the metabolic factors in pre- and post-menopausal women.
  
  
  METHODS
  A cross-sectional study has been carried out for 34 subjects who were in post-menopause and 31 subjects who had regular menstruation in south Indian rural women. Anthropometric indices, blood pressure, fasting blood sugar (FBS), fasting lipid profile, fasting leptin and resistin levels were measured.
  
  
  RESULTS
  In a total of 65 subjects, the mean age of pre-menopausal group was 38.65±6.21 and that of post-menopausal group was 55.32±6.32. Fasting serum leptin level was increased considerably in post-menopausal women when compared to pre-menopausal women (P=0.018). Resistin has no significant relationship with metabolic factors except Body Mass Index (BMI) in both the groups. Triglycerides and FBS were lower in pre-menopausal group when compared to post-menopausal group (P<0.001). Leptin was well correlated with BMI in pre-menopausal women (r(2)=0.7120, P<0.0001) as well as post-menopausal women (r(2)=0.2470, P=0.0028). Leptin also had significant correlation with FBS in both pre (r(2)=0.1373, P=0.0402) and post-menopausal women (r(2)=0.2141, P=0.0401). Systolic blood pressure was positively associated with the leptin levels in post-menopausal women (P<0.001).
  
  
  CONCLUSIONS
  Leptin was found to have significant association with metabolic factors when compared to resistin in pre- and post-menopausal women and there is no doubt that association of BMI and FBS elevates the level of leptin in both the category.
authors.affiliation: Interdisciplinary School of Indian System of Medicine, SRM University, Kattankulathur 603203, Tamil Nadu, India.
authors.forename: Tanu
authors.initials: T
authors.lastname: Priya
authors.forename: Minakshi G
authors.initials: MG
authors.lastname: Chowdhury
authors.forename: Karunamoorthy
authors.initials: K
authors.lastname: Vasanth
authors.forename: Thangavel Mahalingam
authors.initials: TM
authors.lastname: Vijayakumar
authors.forename: Kaliappan
authors.initials: K
authors.lastname: Ilango
authors.forename: Aruna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Govind Prasad
authors.initials: GP
authors.lastname: Dubey
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D052243:Resistin / Q000097:blood*; D018570:Risk Assessment; D012424:Rural Population; D016387:Women's Health
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin; D052243:Resistin
keywords: Leptin; Lipid profile; Menopause; Metabolic syndrome; Obesity; Resistin