title: Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.
abstract: Organozinc reagents react with the SO2 surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones. This transformation has a broad scope and is compatible with a wide range of structural motifs of medicinal chemistry relevance including nitrile, secondary carbamates, and nitrogen-containing heterocycles.
authors.affiliation: Pfizer Worldwide Medicinal Chemistry , Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Rocke
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Bahnck
authors.forename: Michael
authors.initials: M
authors.lastname: Herr
authors.forename: Sophie
authors.initials: S
authors.lastname: Lavergne
authors.forename: Vincent
authors.initials: V
authors.lastname: Mascitti
authors.forename: Christian
authors.initials: C
authors.lastname: Perreault
authors.forename: Jana
authors.initials: J
authors.lastname: Polivkova
authors.forename: Andrei
authors.initials: A
authors.lastname: Shavnya
mesh_terms: D003622:Dapsone / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D013450:Sulfones; D003622:Dapsone; D015032:Zinc