title: Effect of peripheral D₂ dopamine receptor antagonist domperidone on metabolism, feeding behavior, and locomotor activity of rats.
abstract: We studied the possibility of activation of the central dopaminergic system compartment by modulating activity of D2 dopamine receptors in the gastrointestinal tract with domperidone, an antagonist not crossing the blood-brain barrier. Intragastric administration of 0.1 mg/kg domperidone to rats was followed by a significant decrease in feeding behavior and stimulation of basal metabolism, but had no effect on locomotor activity of animals in a Phenomaster system. These effects are typical of psychostimulant agents that stimulate dopamine release from nerve endings in the nucleus accumbens and some regions of the brain cortex. Our results indicate that physiological functions associated with activity of the central dopaminergic system can be modulated through peripheral dopamine receptors.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. s-sudakov@nphys.ru.
authors.forename: S K
authors.initials: SK
authors.lastname: Sudakov
authors.forename: V G
authors.initials: VG
authors.lastname: Bashkatova
mesh_terms: D000818:Animals; D004294:Domperidone / Q000008:administration & dosage*; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D065127:Dopamine D2 Receptor Antagonists; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004294:Domperidone