title: GISTs' classifications in predicting aggressive behavior: a single institution experience.
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. When making treatment plan it is very important to make proper tumor aggressiveness estimation. Traditionally, the best prognostic factors are tumor size and number of mitoses. The aim of this study was to define which GIST classification (Amin's or Newman's classification or Fletcher's Consensus Criteria) is the most significant determining prognosis and has the strongest impact on survival. This study included 63 GIST patients whose tumor specimens were evaluated by standard histopathological methods and classified based on histological assessment of malignant behavior to the three different systems. Comparison of those classification systems was done and none of them was proven to be statistically significantly better in predicting overall survival and probability of lethal outcome. We conclude that all three classifications are comparable in prediction of malignant behavior. The worst prognostic factor is existence of metastases at the time of disease diagnosis.
authors.affiliation: University of Zagreb, University Hospital Center "Sestre milosrdnice", University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia. rseparov@gmail.com
authors.forename: Robert
authors.initials: R
authors.lastname: Separović
authors.forename: Tajana
authors.initials: T
authors.lastname: Silovski
authors.forename: Mirjana
authors.initials: M
authors.lastname: Pavlović
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Silovski
authors.forename: Branko
authors.initials: B
authors.lastname: Dmitrović
authors.forename: Sven
authors.initials: S
authors.lastname: Kurbel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000374:Aggression / Q000523:psychology*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000145:classification* / Q000401:mortality / Q000523:psychology*; D046152:Gastrointestinal Stromal Tumors / Q000145:classification* / Q000401:mortality / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors