title: Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro-in vivo evaluations.
abstract: The present study deals with the development and evaluations of stomach-specific floating capsules containing salbutamol sulfate-loaded oil-entrapped alginate-based beads. Salbutamol sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10h (R10 h) from capsules was analyzed by 3(2) factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R10 h of 56.96 ± 2.92%. These capsules showed floatation over 6h and sustained drug release over 10h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
authors.affiliation: Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
authors.forename: Jadupati
authors.initials: J
authors.lastname: Malakar
authors.affiliation: Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
authors.forename: Prabir Kumar
authors.initials: PK
authors.lastname: Datta
authors.affiliation: Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
authors.forename: Saikat Das
authors.initials: SD
authors.lastname: Purakayastha
authors.affiliation: Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Dey
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak2003@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
mesh_terms: D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D010316:Particle Size; D011817:Rabbits; D013499:Surface Properties
chemical_list: D000464:Alginates; D002214:Capsules; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D000420:Albuterol
keywords: Floating system; Gastroretention; Salbutamol sulfate