title: Increased formation of autophagosomes in ectromelia virus-infected primary culture of murine bone marrow-derived macrophages.
abstract: Induction of autophagy by ectromelia virus (ECTV) in primary cultures of bone marrow-derived macrophages (BMDMs) was investigated. The results showed that ECTV infection of BMDMs resulted in increased formation of autophagosomes, increased level of LC3-II protein present in aggregates and extensive cytoplasmic vacuolization. These data indicate an increased autophagic activity in BMDMs during ECTV infection.
authors.forename: L
authors.initials: L
authors.lastname: Martyniszyn
authors.forename: L
authors.initials: L
authors.lastname: Szulc-Dąbrowska
authors.forename: A
authors.initials: A
authors.lastname: Boratyńska-Jasińska
authors.forename: M
authors.initials: M
authors.lastname: Niemiałtowski
mesh_terms: D000818:Animals; D001343:Autophagy; D002460:Cell Line; D002478:Cells, Cultured; D004481:Ectromelia virus / Q000502:physiology*; D004482:Ectromelia, Infectious / Q000378:metabolism / Q000503:physiopathology* / Q000821:virology; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins