title: Glioblastoma multiforme arising from dysembryoplastic neuroepithelial tumor in a child in the absence of therapy.
abstract: Dysembryoplastic neuroepithelial tumors (DNETs) are considered as low-grade tumors commonly associated with intractable seizures. We report a case of an unusual hemispheric DNET in a young child presenting with new-onset focal seizures. The tumor was notable for its atypical neuroimaging features and very rapid malignant transformation into a glioblastoma multiforme in the absence of radiation or chemotherapy, 1-year postdiagnosis. Our case highlights the malignant potential of atypical DNETs in the absence of therapy.
authors.affiliation: Departments of *Radiology †Pediatrics ‡Pathology §Neurosciences, San Diego and Rady Children's Hospital, University of California, San Diego, CA.
authors.forename: Nathaniel A
authors.initials: NA
authors.lastname: Chuang
authors.forename: Janet M
authors.initials: JM
authors.lastname: Yoon
authors.forename: Robert O
authors.initials: RO
authors.lastname: Newbury
authors.forename: John R
authors.initials: JR
authors.lastname: Crawford
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000209:etiology / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018302:Neoplasms, Neuroepithelial / Q000150:complications / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000150:complications / Q000473:pathology*