title: Synthesis of 3,4-dibenzyltetrahydrofuran lignans (9,9'-epoxylignanes).
abstract: Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels-Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, P.O. Box 55, FIN-00014, University of Helsinki, Helsinki, 00560, Finland. kristiina.wahala@helsinki.fi.
authors.forename: Monika
authors.initials: M
authors.lastname: Pohjoispää
authors.forename: Kristiina
authors.initials: K
authors.lastname: Wähälä
mesh_terms: D005663:Furans / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005663:Furans; D017705:Lignans; C018674:tetrahydrofuran