title: CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: a meta-analysis.
abstract: Previous studies proposed that CYP1A2 rs762551 polymorphism might be associated with risk of lung cancer by influencing the function of CYP1A2. However, previous studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer reported inconsistent findings. We performed a meta-analysis of the published case-control studies to assess the association between CYP1A2 rs762551 polymorphism and risk of lung cancer. PubMed and Embase were searched to identify relevant studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer, and seven studies with a total of 3,320 subjects were finally included into the meta-analysis. The pooled odds ratio (OR) and 95 % confidence interval (95%CI) was calculated to evaluate the association. Meta-analysis of total studies showed that CYP1A2 rs762551 polymorphism contributed to risk of lung cancer under all four genetic models (C versus A: OR = 1.26, 95%CI 1.13 to 1.40, P < 0.001; CC versus AA: OR = 1.61, 95%CI 1.28 to 2.04, P < 0.001; CC versus AA/AC: OR = 1.52, 95%CI 1.11 to 2.09, P = 0.009; CC/AC versus AA: OR = 1.28, 95%CI 1.10 to 1.48, P = 0.001). Subgroup analysis based on ethnicity further suggested that CYP1A2 rs762551 polymorphism was associated with risk of lung cancer in Caucasians. These results from the meta-analysis suggest that CYP1A2 rs762551 polymorphism contributes to risk of lung cancer.
authors.affiliation: Department of General Thoracic Surgery, Daping Hospital and Institute of Surgery Research, the Third Millitary Medical University, 10# Changjiang Zhilu Road, 400042, Yuzhong Distric, Chongqing, People's Republic of China, mzcqdoc@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Taiqian
authors.initials: T
authors.lastname: Gong
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Niu
authors.forename: Ru-Wen
authors.initials: RW
authors.lastname: Wang
authors.forename: Yao-Guang
authors.initials: YG
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2