title: Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study.
abstract: OBJECTIVE
  To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method.
  
  
  METHODS
  30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method.
  
  
  RESULTS
  We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013).
  
  
  CONCLUSIONS
  Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed.
authors.affiliation: Department of OB&GYN, Faculty of Medicine, Gaziantep University, Sahinbey, Turkey.
authors.forename: Özgür Bilgin
authors.initials: ÖB
authors.lastname: Yiyenoğlu
authors.forename: Mete Gürol
authors.initials: MG
authors.lastname: Uğur
authors.forename: Hüseyin Çağlayan
authors.initials: HÇ
authors.lastname: Özcan
authors.forename: Günay
authors.initials: G
authors.lastname: Can
authors.forename: Ebru
authors.initials: E
authors.lastname: Öztürk
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Balat
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy / Q000097:blood; D011261:Pregnancy Trimester, First / Q000097:blood; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants