title: Cerebrospinal fluid pressure and glaucoma: regulation of trans-lamina cribrosa pressure.
abstract: Increased trans-lamina cribrosa pressure difference (TLCPD), the difference of intraocular pressure (IOP) and orbital cerebrospinal fluid pressure (CSF-P), has been investigated as a possible risk factor in glaucoma pathogenesis. In fact, lower CSF-P in the setting of normal IOP has been implicated as a potential risk factor for normal tension glaucoma. Increased TLCPD has been associated with decreased neuroretinal rim area and increased visual field defects. Furthermore, dysregulation of systemic blood pressure has been associated with changes in IOP. Recent studies have also suggested that increased body mass index (BMI) is associated with decreased prevalence of glaucoma, which may be due to an increased CSF-P with increased BMI found in many studies. Given the interaction of various pressures, their role in glaucoma pathophysiology has come under investigation and warrants further study in order to better understand the aetiology and progression of glaucoma.
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Marek
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Kanakamedala
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Annahita
authors.initials: A
authors.lastname: Amireskandari
authors.affiliation: Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana, USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Carichino
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana, USA.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Guidoboni
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Leslie Abrams
authors.initials: LA
authors.lastname: Tobe
authors.affiliation: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, USA.
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D057066:Low Tension Glaucoma / Q000503:physiopathology*; D009898:Optic Disk / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology; D012307:Risk Factors; D014786:Vision Disorders / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology
keywords: Glaucoma; Intraocular pressure