title: Building a neurocognitive profile of thought disorder in schizophrenia using a standardized test battery.
abstract: A core symptom of schizophrenia is thought disorder (TD). The cognitive abilities of semantic processing and executive function are argued to be etiologically linked to TD. However, there has been no comprehensive investigation of neurocognition in TD to date. The neurocognitive profile of 58 schizophrenia patients and 48 healthy controls was examined using the MATRICS Consensus Cognitive Battery and the D-KEFS Color-Word Interference Test. TD patients performed more poorly than non-TD patients on the cognitive domains of Verbal Learning and Inhibition, reflective of semantic and executive function respectively, confirming their critical roles over and above other cognitive deficits in schizophrenia.
authors.affiliation: Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred Hospital, Melbourne, VIC 3004, Australia. Electronic address: Eric.Tan@monash.edu.
authors.forename: E J
authors.initials: EJ
authors.lastname: Tan
authors.affiliation: Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred Hospital, Melbourne, VIC 3004, Australia; Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: S L
authors.initials: SL
authors.lastname: Rossell
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012660:Semantics; D014706:Verbal Learning
chemical_list: D014150:Antipsychotic Agents
keywords: Executive function; MATRICS; Neurocognition; Schizophrenia; Semantic processing; Thought disorder