title: Ultrasound-promoted one-pot, four-component synthesis of pyridin-2(1H)-one derivatives.
abstract: An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
authors.affiliation: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China. imbjxwang@gmail.com.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Juxian
authors.initials: J
authors.lastname: Wang
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
mesh_terms: D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013016:Sound
chemical_list: D011725:Pyridines; C023666:pyridine