title: Comparative Genomics and Systems Biology of Malaria ParasitesPlasmodium.
abstract: Malaria is a serious infectious disease that causes over one million deaths yearly. It is caused by a group of protozoan parasites in the genusPlasmodium. No effective vaccine is currently available and the elevated levels of resistance to drugs in use underscore the pressing need for novel antimalarial targets. In this review, we survey omics centered developments inPlasmodiumbiology, which have set the stage for a quantum leap in our understanding of the fundamental processes of the parasite life cycle and mechanisms of drug resistance and immune evasion.
authors.affiliation: Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Jianying
authors.initials: J
authors.lastname: Gu
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
keywords: Plasmodium; drug; genomics; interactome; malaria; proteomics; systems biology; transcriptomics; vaccine