title: The prevalence and predictors of active brown adipose tissue in Chinese adults.
abstract: OBJECTIVE
  Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals.
  
  
  METHODS
  A total of 31,088 consecutive subjects aged ≥18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study.
  
  
  METHODS
  We measured BAT activity via (18)F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals.
  
  
  RESULTS
  In both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group.
  
  
  CONCLUSIONS
  In Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.
authors.affiliation: The Division of Endocrinology and Metabolism, the Department of Internal Medicine.
authors.forename: Zhaoyun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Cypess
authors.forename: Qing
authors.initials: Q
authors.lastname: Miao
authors.forename: Hongying
authors.initials: H
authors.lastname: Ye
authors.forename: Chong Wee
authors.initials: CW
authors.lastname: Liew
authors.forename: Qiongyue
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ruidan
authors.initials: R
authors.lastname: Xue
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Xu
authors.forename: Qiqun
authors.initials: Q
authors.lastname: Tang
authors.forename: Renming
authors.initials: R
authors.lastname: Hu
authors.forename: Yihui
authors.initials: Y
authors.lastname: Guan
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D015995:Prevalence; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose