title: Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease.
abstract: Development and fate of the stem cell are regulated by extrinsic signals from the environment. Endocrine-disrupting chemicals which perturb hormonal signaling in utero and during early childhood may cause deregulation of multiple developmental processes, ranging from breakdown of stem cell niche architecture, developmental reprograming and altered stem cell fate to impaired organ and gonad development and sexual differentiation. Therefore, study of the environmental effects on stem cell integrity and normal development is a new and emerging focus for developmental biologists and cell toxicologists. When combined with new human and mouse stem cell-based models, stem cell differentiation dynamics can be studied in more biologically relevant ways. In this study, we review the current status of our understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis.
authors.affiliation: Department of Environmental Heath, University of Cincinnati, 3223 Eden Avenue, Cincinnati, Ohio 45267-0056, USA Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267-0575, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Kopras
authors.forename: Veena
authors.initials: V
authors.lastname: Potluri
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Bermudez
authors.forename: Karin
authors.initials: K
authors.lastname: Williams
authors.forename: Scott
authors.initials: S
authors.lastname: Belcher
authors.forename: Susan
authors.initials: S
authors.lastname: Kasper
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D004194:Disease; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D005854:Germ Cells / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008297:Male; D042361:Mammary Glands, Human / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D013234:Stem Cells / Q000187:drug effects*
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants
keywords: cancer stem cell; endocrine disruptors; organ development; stem cell/progenitor cell; steroid hormone receptors