title: Effects of antibodies to glutamate on focal penicillin-induced epileptic activity.
abstract: The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h before application of penicillin (30,000 U/ml) on the sensorimotor cortex was demonstrated: the latency of ictal discharges increased and their frequency decreased.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. karpova777@inbox.ru.
authors.forename: L V
authors.initials: LV
authors.lastname: Kuznetsova
authors.forename: M N
authors.initials: MN
authors.lastname: Karpova
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrile
authors.forename: N Yu
authors.initials: NY
authors.lastname: Klishina
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D018698:Glutamic Acid / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000906:Antibodies; D000927:Anticonvulsants; D010406:Penicillins; D018698:Glutamic Acid