title: Palladium-catalyzed arylation of cyclopropanes via directing group-mediated C(sp3)-H bond activation to construct quaternary carbon centers: synthesis of cis- and trans-1,1,2-trisubstituted chiral cyclopropanes.
abstract: Pd(II)-catalyzed tertiary C(sp(3))-H arylation of cyclopropanes via directing group-mediated C-H activation for the construction of a chiral quaternary carbon center on cyclopropanes using aryl iodides as a coupling partner is reported. The arylation had a wide substrate scope and good functional group tolerance, including heteroaryl iodides, to provide various chiral arylcyclopropanes with the cis- and trans-1,1,2-trisubstituted structures.
authors.affiliation: Faculty of Pharmaceutical Sciences and Center for Research and Education on Drug Development, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hoshiya
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Arisawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D009942:Organometallic Compounds; D010165:Palladium; D002244:Carbon