title: Positron emission tomography radiotracers for imaging hypoxia.
abstract: Localized hypoxia, the physiological hallmark of many clinical pathologies, is the consequence of acute or chronic ischemia in the affected region or tissue. The versatility, sensitivity, quantitative nature, and increasing availability of positron emission tomography (PET) make it the preclinical and clinical method of choice for functional imaging of tissue hypoxia at the molecular level. The progress and current status of radiotracers for hypoxia-specific PET imaging are reviewed in this article including references mainly focused on radiochemistry and also relevant to molecular imaging of hypoxia in preclinical and clinical studies.
authors.affiliation: Department of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
authors.forename: Melinda
authors.initials: M
authors.lastname: Wuest
authors.forename: Frank
authors.initials: F
authors.lastname: Wuest
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging*; D007553:Isotope Labeling; D009593:Nitroimidazoles / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D009593:Nitroimidazoles; D019275:Radiopharmaceuticals
keywords: fluorine-18; radiochemistry; radiotracers; tumor hypoxia