title: Nickel oxide hollow microsphere for non-enzyme glucose detection.
abstract: A facile strategy has been developed to fabricate nickel oxide hollow microspheres (NiO-HMSs) through a solvothermal method by using a mixed solvent of ethanol and water with the assistance of sodium dodecyl sulfate (SDS). Various techniques, including transmission electron microscopy (TEM), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), were used to characterize the morphology and the structure of as-prepared samples. It was confirmed that the products possess a hollow microsphere structure that is constructed by interconnecting porous nanoplate framework. Electrochemical studies indicate that the NiO-HMS exhibits excellent stability and high catalytic activity for electrocatalytic oxidation of glucose in alkaline solutions, which enables the NiO-HMS to be used in enzyme-free amperometric sensors for glucose determination. It was demonstrated that the NiO-HMS-based glucose biosensor offers a variety of merits, such as a wide linear response window for glucose concentrations of 1.67 μM-6.87 mM, short response time (3 s), a lower detection limit of 0.53 μM (S/N=3), high sensitivity (~2.39 mA mM(-1) cm(-2)) as well as good stability and repeatability.
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States.
authors.forename: Suqin
authors.initials: S
authors.lastname: Ci
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States.
authors.forename: Taizhong
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States. Electronic address: wenzhenhai@yahoo.com.
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Wen
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States.
authors.forename: Shumao
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States.
authors.forename: Shun
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Milwaukee, 3209 North Maryland Ave Milwaukee, WI 53211, United States.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Steeber
authors.affiliation: Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States. Electronic address: jhchen@uwm.edu.
authors.forename: Junhong
authors.initials: J
authors.lastname: Chen
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods; D006801:Humans; D057230:Limit of Detection; D008863:Microspheres; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D001786:Blood Glucose; D009532:Nickel; C028007:nickel monoxide
keywords: Electrocatalyst; Glucose biosensor; Hollow microsphere; NiO