title: The effects of two different doses of calcium lactate on blood pH, bicarbonate, and repeated high-intensity exercise performance.
abstract: We investigated the effects of low- and high-dose calcium lactate supplementation on blood pH and bicarbonate (Study A) and on repeated high-intensity performance (Study B). In Study A, 10 young, physically active men (age: 24 ± 2.5 years; weight: 79.2 ± 9.45 kg; height: 1.79 ± 0.06 m) were assigned to acutely receive three different treatments, in a crossover fashion: high-dose calcium lactate (HD: 300 mg · kg(-1) body mass), low-dose calcium lactate (LD: 150 mg · kg(-1) body mass) and placebo (PL). During each visit, participants received one of these treatments and were assessed for blood pH and bicarbonate 0, 60, 90, 120, 150, 180, and 240 min following ingestion. In Study B, 12 young male participants (age: 26 ± 4.5 years; weight: 82.0 ± 11.0 kg; height: 1.81 ± 0.07 m) received the same treatments of Study A. Ninety minutes after ingestion, participants underwent 3 bouts of the upper-body Wingate test and were assessed for blood pH and bicarbonate 0 and 90 min following ingestion and immediately after exercise. In Study A, both HD and LD promoted slight but significant increases in blood bicarbonate (31.47 ± 1.57 and 31.69 ± 1.04 mmol · L(-1, respectively) and pH levels (7.36 ± 0.02 and 7.36 ± 0.01, respectively), with no effect of PL. In Study B, total work done, peak power, mean power output were not affected by treatments. In conclusion, low- and high-dose calcium lactate supplementation induced similar, yet very discrete, increases in blood pH and bicarbonate, which were not sufficiently large to improve repeated high-intensity performance.
authors.affiliation: Laboratory of Applied Nutrition and Metabolism, University of São Paulo, São Paulo, Brazil.
authors.forename: Vitor de Salles
authors.initials: Vde S
authors.lastname: Painelli
authors.forename: Rafael Pires
authors.initials: RP
authors.lastname: da Silva
authors.forename: Odilon Marques
authors.initials: OM
authors.lastname: de Oliveira
authors.forename: Luana Farias
authors.initials: LF
authors.lastname: de Oliveira
authors.forename: Fabiana Braga
authors.initials: FB
authors.lastname: Benatti
authors.forename: Tobias
authors.initials: T
authors.lastname: Rabelo
authors.forename: João Paulo Limongi França
authors.initials: JP
authors.lastname: Guilherme
authors.forename: Antonio Herbert
authors.initials: AH
authors.lastname: Lancha
authors.forename: Guilherme Giannini
authors.initials: GG
authors.lastname: Artioli
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000097:blood*; D017610:Calcium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion / Q000187:drug effects*; D055815:Young Adult
chemical_list: D001639:Bicarbonates; D017610:Calcium Compounds; D007773:Lactates; C110051:calcium lactate