title: A convenient method to produce [(14) C]carbon monoxide and its application to the radiosynthesis of [carboxyl-(14) C]celivarone, [carboxyl-(14) C]SSR149744.
abstract: [carboxyl-(14) C]Celivarone was synthesised from barium [(14) C]carbonate with overall radiochemical yields in the range 49-53%. The synthetic route involves [(14) C]carbonylation methodology, which both decreased the number of synthetic steps and increased the yields obtained from previous synthetic routes.
authors.affiliation: Department of Isotope Chemistry and Metabolite Synthesis, Covance Laboratories Ltd., Willowburn Avenue, Alnwick, Northumberland, NE66 2JH, UK; Department of Isotope Chemistry and Metabolite Synthesis, sanofi-aventis, Willowburn Avenue, Alnwick, Northumberland, NE66 2JH, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Whitehead
authors.forename: Sascha
authors.initials: S
authors.lastname: Hartmann
authors.forename: Tenzeela
authors.initials: T
authors.lastname: Ilyas
authors.forename: Keith R
authors.initials: KR
authors.lastname: Taylor
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Kohler
authors.forename: George J
authors.initials: GJ
authors.lastname: Ellames
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001464:Barium; D001572:Benzofurans / Q000138:chemical synthesis*; D002248:Carbon Monoxide / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002254:Carbonates / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D000889:Anti-Arrhythmia Agents; D001572:Benzofurans; D002250:Carbon Radioisotopes; D002254:Carbonates; D019275:Radiopharmaceuticals; D001464:Barium; C006685:barium carbonate; D002248:Carbon Monoxide; C499879:celivarone
keywords: [14C]carbonylation; [carboxyl-14C]celivarone; antiarrhythmic; lithium [14C]formate