title: Functionalized NaA nanozeolites labeled with224,225Ra for targeted alpha therapy.
abstract: The223Ra,224Ra, and225Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides has been studied.224Ra and225Ra, α-particle emitting radionuclides, have been absorbed in the nanometer-sized NaA zeolite (30-70 nm) through simple ion exchange.224,225Ra-nanozeolites exhibited very high stability in solutions containing physiological salt, EDTA, amino acids, and human serum. To make NaA nanozeolite particles dispersed in water their surface was modified with a silane coupling agent containing poly(ethylene glycol) molecules. This functionalization approach let us covalently attach a biomolecule to the NaA nanozeolite surface.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Piotrowska
authors.forename: Edyta
authors.initials: E
authors.lastname: Leszczuk
authors.forename: Frank
authors.initials: F
authors.lastname: Bruchertseifer
authors.forename: Alfred
authors.initials: A
authors.lastname: Morgenstern
authors.forename: Aleksander
authors.initials: A
authors.lastname: Bilewicz
keywords: Drug delivery; Nanomedicine; Nanozeolite; Radiotherapy; Radium radionuclides