title: An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model.
abstract: OBJECTIVE
  To assess the role of the Th1 and Th2 cellular response in the etiology of endometriosis observed in a rat model, with the use of the RESAN immunomodulator.
  
  
  METHODS
  A comparative analysis of cytokines in blood serum typical of Th1 (TNF-α and INF-γ ) and Th2 (IL-4, IL-6, IL-10) cell response in groups of rats, in which RESAN preparation was used as prophylaxis (Gr. I) or treatment (Gr. II) of endometriosis.
  
  
  RESULTS
  The results indicated an increase in the level of cytokines in blood serum typical of Th2 cell response by comparing the second and third stages of the experiment in the second group of rats and a decrease in IL-4 and IL-10 between III and IV stages. There was a significant difference in cytokine levels during the third stage of the experiment by comparing I and II groups of rats. In the III group of rats, levels of IL-10 significantly increased between the II and III stages of the experiment.
  
  
  CONCLUSIONS
  RESAN preparation shows Th2 cell response, inhibiting the development of endometriosis in a rat model. Due to successful prophylactic action, one may speculate that RESAN vaccine may be effective as a complementary treatment after surgical excision.
authors.affiliation: Department of Mother's and Child's Health, K. Marcinkowski University of Medical Sciences, Polna Street 33, 60-535 Poznań, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Szymanowski
authors.forename: J
authors.initials: J
authors.lastname: Niepsuj-Biniaś
authors.forename: A
authors.initials: A
authors.lastname: Dera-Szymanowska
authors.forename: M
authors.initials: M
authors.lastname: Wołuń-Cholewa
authors.forename: A
authors.initials: A
authors.lastname: Yantczenko
authors.forename: E
authors.initials: E
authors.lastname: Florek
authors.forename: T
authors.initials: T
authors.lastname: Opala
authors.forename: M
authors.initials: M
authors.lastname: Murawski
authors.forename: K
authors.initials: K
authors.lastname: Wiktorowicz
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004715:Endometriosis / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D007155:Immunologic Factors / Q000627:therapeutic use; D056747:Immunomodulation; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D019496:Cancer Vaccines; D007155:Immunologic Factors; D015850:Interleukin-6; C540762:RESAN vaccine; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma