title: Thermosensitive methyl cellulose-based injectable hydrogels for post-operation anti-adhesion.
abstract: Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K(+) and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO3 macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO3 loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties.
authors.affiliation: Huanhu Hospital, Tianjin 300060, PR China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Gao
authors.forename: Xiulan
authors.initials: X
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianping
authors.initials: J
authors.lastname: Gao
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D002432:Cecum / Q000166:cytology / Q000187:drug effects / Q000601:surgery; D002478:Cells, Cultured; D005260:Female; D020100:Hydrogels; D007267:Injections; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects; D011184:Postoperative Period; D051381:Rats; D013696:Temperature; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D020100:Hydrogels; D002266:Carboxymethylcellulose Sodium
keywords: Anti-adhesion; Biomaterial; Chitosan; Hydrogel; Methyl cellulose; PEG