title: [Current status and perspectives on the development of AD therapeutics based on amyloid cascade hypothesis].
authors.affiliation: Department of Neuropathology, School of Medicine, The University of Tokyo.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwatsubo
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D015415:Biomarkers; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation; D059906:Neuroimaging; D010446:Peptide Fragments / Q000378:metabolism; D053763:Presenilins / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers; D010446:Peptide Fragments; D053763:Presenilins; C075222:amyloid beta-protein (1-42)