title: Sex-specific genomic biomarkers for individualized treatment of life-threatening diseases.
abstract: Numerous studies have demonstrated sex differences in drug reactions to the same drug treatment, steering away from the traditional view of one-size-fits-all medicine. A premise of this study is that the sex of a patient influences difference in disease characteristics and risk factors. In this study, we intend to exploit and to obtain better sex-specific biomarkers from gene-expression data. We propose a procedure to isolate a set of important genes as sex-specific genomic biomarkers, which may enable more effective patient treatment. A set of sex-specific genes is obtained by a variable importance ranking using a combination of cross-validation methods. The proposed procedure is applied to three gene-expression datasets.
authors.affiliation: Department of Mathematics and Statistics, California State University, 1250 Bellflower Boulevard, Long Beach, CA 90840-1001, USA.
authors.forename: Hojin
authors.initials: H
authors.lastname: Moon
authors.forename: Karen L
authors.initials: KL
authors.lastname: Lopez
authors.forename: Grace I
authors.initials: GI
authors.lastname: Lin
authors.forename: James J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000465:Algorithms; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D008957:Models, Genetic; D057285:Precision Medicine; D011379:Prognosis; D012307:Risk Factors; D012727:Sex Characteristics; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D005819:Genetic Markers