title: Evaluating DAPK as a therapeutic target.
abstract: Death associated protein kinase 1 (DAPK) is an important serine/theoreine kinase involved in various cellular processes such as apoptosis, autophagy and inflammation. DAPK expression and activity are misregulated in multiple diseases including cancer, neuronal death, stoke, et al. Methylation of the DAPK gene is common in many types of cancer and can lead to loss of DAPK expression. In this review, we summarize the pathological status and functional roles of DAPK in disease and compare the published reagents that can manipulate the expression or activity of DAPK. The pleiotropic functions of DAPK make it an intriguing target and the barriers and opportunities for targeting DAPK for future clinical application are discussed.
authors.affiliation: Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350108, Fujian, People's Republic of China.
authors.forename: Yide
authors.initials: Y
authors.lastname: Huang
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Libin
authors.initials: L
authors.lastname: Guo
authors.forename: Ted R
authors.initials: TR
authors.lastname: Hupp
authors.forename: Yao
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D016923:Cell Death; D064550:Death-Associated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020536:Enzyme Activators / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000473:pathology
chemical_list: D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D064550:Death-Associated Protein Kinases