title: Synthesis, characterization, and evaluation of radiometal-containing peptide nucleic acids.
abstract: Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities, PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this book chapter, we report on the current developments towards the preparation of radiometal-containing PNA constructs and summarize the protocols for labeling these probes with (99m)Tc, (111)In, (64)Cu, (90)Y, and (177)Lu.
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz- Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Stephan
authors.forename: Christian
authors.initials: C
authors.lastname: Foerster
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
mesh_terms: D001483:Base Sequence; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D007553:Isotope Labeling; D008670:Metals / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000235:genetics; D011725:Pyridines / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D008670:Metals; D020135:Peptide Nucleic Acids; D011725:Pyridines; D011868:Radioisotopes; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C023666:pyridine