title: The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds.
abstract: Hard-to-heal wounds represent a significant problem to patients, health care professionals, and health care system. They can be formed as a result of mechanical injuries and burns, and any co-existing chronic disease increases the risk of their emergence. Diabetics are at a greater risk of developing chronic wounds because of poor circulation, slow healing times, vascular disease and neuropathy. The aim of this study was to determine the antimicrobial activity of geranium oil against Gram-negative bacterial clinical strains. Clinical strains were isolated from patients with difficult-to-treat wounds and a comprehensive evaluation of their sensitivity to antibiotics was carried out. The constituents of geranium oil were specified by GC-FID-MS analysis. The micro-dilution broth method was used to check the inhibition of microbial growth at various concentrations of geranium oil. The tested geranium oil was efficacious against Gram-negative pathogens responsible for problems with wound treatment. The results suggest that geranium oil may be considered an effective component of therapy in the case of frequent recurrences of infections caused by resistant pathogens.
authors.affiliation: Medical and Sanitary Microbiology Department, Medical University of Lodz, Lodz, Pl Hallera 1, 90-647, Poland. Electronic address: monika.sienkiewicz@umed.lodz.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Sienkiewicz
authors.affiliation: Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland. Electronic address: dermatologia@umed.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Poznańska-Kurowska
authors.affiliation: Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kaszuba
authors.affiliation: Pharmacology and Toxicology Department, Medical University of Lodz, Lodz, Pl. Hallera 1, 90-647, Poland. Electronic address: edward.kowalczyk@umed.lodz.pl.
authors.forename: Edward
authors.initials: E
authors.lastname: Kowalczyk
mesh_terms: D016971:Citrobacter freundii / Q000187:drug effects* / Q000302:isolation & purification; D044083:Cronobacter sakazakii / Q000187:drug effects* / Q000302:isolation & purification; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D031315:Geranium; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009822:Oils, Volatile / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects* / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014946:Wound Infection / Q000382:microbiology*
chemical_list: D009822:Oils, Volatile
keywords: Geranium oil; Gram-negative pathogens; Inhibiting activity; Wounds