title: CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population.
abstract: BACKGROUND
  Coronary atherosclerosis, the most common form of coronary artery disease (CAD), is characterized by accumulation of lipid in the walls of coronary arteries. Recent data from clinical trials have showed that high-density lipoprotein cholesterol (HDL-C) has causal role in the pathogenesis and development of coronary atherosclerosis. Cholesteryl ester transfer protein (CETP) is an important regulator of plasma HDL-C. Several genetic mutations in the CETP gene were found to be associated with HDL-C levels. The aim of the present study is to evaluate the association of HDL-C-related CETP polymorphisms and risk of coronary atherosclerosis.
  
  
  METHODS
  We investigated the association of seven single nucleotide polymorphisms (SNP) (rs1800775, rs708272, rs5882, rs1532624, rs1864163, rs7499892, and rs9989419) in the CETP gene with the risk of coronary atherosclerosis and levels of HDL-C in a case-control study in China. Included in the study were 420 patients with coronary atherosclerosis and 424 healthy controls. SNP genotyping was performed by TaqMan allelic discrimination assay and serum lipid levels were measured by standard laboratory methods.
  
  
  RESULTS
  Carriers of the AA and GA + AA genotypes of rs708272 had significant lower risks of coronary atherosclerosis (OR = 0.55, 95% CI: 0.36-0.85, p = 0.003; OR = 0.67, 95% CI: 0.50-0.90, p = 0.007, respectively) compared to those with GG genotype. These relations remained significant after adjustment for confounding effects of age, smoking, diabetes and hypertension. The rs1800775 polymorphism was significantly associated with serum levels of HDL-C in healthy controls (p = 0.04). Besides, rs708272 was in close linkage disequilibrium (LD) with rs1800775 in this study.
  
  
  CONCLUSIONS
  Our findings indicated that CETP rs708272 may be associated with the risk of coronary atherosclerosis and rs1800775 may influence serum HDL-C levels in healthy controls in Chinese.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Li Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhong
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Jia Qing
authors.initials: JQ
authors.lastname: Shao
authors.affiliation: Departments of Cardiology, School of Medicine, Nanjing University, Jinling Hospital/Nanjing General Hospital of Nanjing Military Command, 305 Zhongshan East Road, Nanjing, Jiangsu Province 210002, China. zero991127@hotmail.com.
authors.forename: Shi Sen
authors.initials: SS
authors.lastname: Jiang
authors.forename: Jian Bin
authors.initials: JB
authors.lastname: Gong
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL