title: W. W. "Mo" Cleland: a catalytic life.
abstract: Professor W. Wallace Cleland, the architect of modern steady-state enzyme kinetics, died on March 6, 2013, from injuries sustained in a fall outside of his home. He will be most remembered for giving the enzyme community Ping-Pong kinetics and the invention of dithiothreitol (DTT). He pioneered the utilization of heavy atom isotope effects for the elucidation of the chemical mechanisms of enzyme-catalyzed reactions. His favorite research journal was Biochemistry, in which he published more than 135 papers beginning in 1964 with the disclosure of DTT.
authors.affiliation: Department of Chemistry and Chemical Biology, University of New Mexico , Albuquerque, New Mexico 87131, United States.
authors.forename: Debra
authors.initials: D
authors.lastname: Dunaway-Mariano
authors.forename: Hazel M
authors.initials: HM
authors.lastname: Holden
authors.forename: Frank M
authors.initials: FM
authors.lastname: Raushel
mesh_terms: D055162:Biocatalysis / Q000187:drug effects; D001671:Biochemistry / Q000266:history*; D041961:Deuterium Exchange Measurement / Q000266:history; D004229:Dithiothreitol / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D007700:Kinetics; D050538:Malate Dehydrogenase (NADP+) / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D010084:Oxidation-Reduction / Q000187:drug effects; D010678:Philately / Q000266:history; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D019163:Reducing Agents / Q000737:chemistry / Q000494:pharmacology; D013053:Spectrophotometry / Q000266:history; D013439:Sulfhydryl Reagents / Q000737:chemistry / Q000494:pharmacology; D014481:United States; D014922:Wisconsin
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D011506:Proteins; D019163:Reducing Agents; D013439:Sulfhydryl Reagents; D050538:Malate Dehydrogenase (NADP+); D004229:Dithiothreitol