title: Long-term depression: a cell biological view.
abstract: Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.
authors.affiliation: Department of Neuroscience, Genentech, Inc., , 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Morgan
authors.initials: M
authors.lastname: Sheng
authors.forename: Ali
authors.initials: A
authors.lastname: Ertürk
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D020169:Caspases
keywords: caspase; dendritic spine; local apoptosis; long-term depression; long-term potentiation; spine elimination