title: [Amyotrophic lateral sclerosis in totally locked-in state].
abstract: Seven autopsy patients with amyotrophic lateral sclerosis (ALS) in totally locked-in state (TLS) were examined neuropathologically. The patients were composed of 4 males and 3 females, and 3 with familial, 1 sporadic but with mutation in SOD1 gene, and 3 sporadic patients with unremarkable gene mutation. The brains weighed 715, 783, 1,019, 1,050, 1,170, 1,190 or 1,233 g. The tegmentum of the brain stem was markedly degenerated in every patient, and the tracts relating to the somatic sensory and auditory were involved in the lesions.
authors.affiliation: Department of Brain Disease Research, Shinshu University School of Medicine.
authors.forename: Kiyomitsu
authors.initials: K
authors.lastname: Oyanagi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimizu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagao
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Mineo
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Shiro
authors.initials: S
authors.lastname: Matsubara
authors.forename: Takashi
authors.initials: T
authors.lastname: Komori
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D062207:Brain-Computer Interfaces; D003142:Communication; D003143:Communication Devices for People with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology