title: Mechanically driven accumulation of microscale material at coupled solid-fluid interfaces in biological channels.
abstract: The accumulation of microscale materials at solid-fluid interfaces in biological channels is often the initial stage of certain growth processes, which are present in some forms of atherosclerosis. The objective of this work is to develop a relatively simple model for such accumulation, which researchers can use to qualitatively guide their analyses. Specifically, the approach is to construct rate equations for the accumulation at the solid-fluid interface as a function of the intensity of the shear stress. The accumulation of material subsequently reduces the cross-sectional area of the channel until the fluid-induced shear stress at the solid-fluid interface reaches a critical value, which terminates the accumulation rate. Characteristics of the model are explored analytically and numerically.
authors.affiliation: Department of Mechanical Engineering, University of California, , 6195 Etcheverry Hall, Berkeley, CA 94720-1740, USA.
authors.forename: T I
authors.initials: TI
authors.lastname: Zohdi
mesh_terms: D000465:Algorithms; D050197:Atherosclerosis / Q000503:physiopathology*; D003198:Computer Simulation; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical; D013499:Surface Properties; D013997:Time Factors
keywords: accumulation; channel flow; solid–fluid interfaces