title: A vinyl chloride-exposed worker with an adrenal gland angiosarcoma: a case report.
abstract: Adrenal epithelioidangiosarcoma (AEA) is a rare neoplasm that accounts for less than 1% of sarcomas. Due to its rarity, it can easily be misdiagnosed, both by the clinician and the pathologist. Data on the patient's occupational history was collected and analyzed. The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma". We report a case of adrenal epithelioidangiosarcoma (AEA) in a 68 yr-old Caucasian male factory worker exposed to Vinyl Chloride (VC) for 15 yr. He underwent surgery, chemotherapy and radiotherapy. Hepatic angiosarcoma is a known consequence of VC exposure, but occupational causality of extra-hepatic angiosarcoma is controversial. Extra-hepatic angiosarcomas have been reported in VC workers, but never AEA. Cancerogenic effects of VC involve all endothelial areas of the body and extra-hepatic endothelial tumors may also be caused by this substance. This is the first published report of AEA diagnosed in a worker exposed to VC.
authors.affiliation: Pathology Department, "Perrino" Hospital, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Criscuolo
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Valerio
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Gianicolo
authors.forename: Emilio A L
authors.initials: EA
authors.lastname: Gianicolo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Portaluri
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology; D000368:Aged; D002273:Carcinogens / Q000633:toxicity*; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D014752:Vinyl Chloride / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D014752:Vinyl Chloride