title: Hypofractionated stereotactic radiosurgery in a large bilateral thalamic and Basal Ganglia arteriovenous malformation.
abstract: Purpose. Arteriovenous malformations (AVMs) in the basal ganglia and thalamus have a more aggressive natural history with a higher morbidity and mortality than AVMs in other locations. Optimal treatment-complete obliteration without new neurological deficits-is often challenging. We present a patient with a large bilateral basal ganglia and thalamic AVM successfully treated with hypofractionated stereotactic radiosurgery (HFSRS) with intensity modulated radiotherapy (IMRT). Methods. The patient was treated with hypofractionated stereotactic radiosurgery to 30 Gy at margin in 5 fractions of 9 static fields with a minimultileaf collimator and intensity modulated radiotherapy. Results. At 10 months following treatment, digital subtraction angiography showed complete obliteration of the AVM. Conclusions. Large bilateral thalamic and basal ganglia AVMs can be successfully treated with complete obliteration by HFSRS with IMRT with relatively limited toxicity. Appropriate caution is recommended.
authors.affiliation: Division of Neurological Surgery, University of Missouri-Columbia School of Medicine, One Hospital Drive, MC 321, Columbia, MO 65212, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Lee
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Steven
authors.initials: S
authors.lastname: Westgate
authors.forename: Ashish
authors.initials: A
authors.lastname: Nanda
authors.forename: Marshall
authors.initials: M
authors.lastname: Cress
authors.forename: N Scott
authors.initials: NS
authors.lastname: Litofsky