title: Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling.
abstract: Apart from their endocrine functions renin-expressing cells play an important functional role as mural cells of the developing preglomerular arteriolar vessel tree in the kidney. The recruitment of renin-expressing cells from the mesenchyme to the vessel wall is not well understood. Assuming that it may follow more general lines of pericyte recruitment to endothelial tubes we have now investigated the relevance of the platelet-derived growth factor (PDGF)-B-PDGFR-β signaling pathway in this context. We studied renin expression in kidneys lacking PDGFR-β in these cells and in kidneys with reduced endothelial PDGF-B expression. We found that expression of renin in the kidneys under normal and stimulated conditions was not different from wild-type kidneys. As expected, PDGFR-β immunoreactivity was found in mesangial, adventitial and tubulo-interstitial cells but not in renin-expressing cells. These findings suggest that the PDGF-B-PDGFR-β signaling pathway is not essential for the recruitment of renin-expressing cells to preglomerular vessel walls in the kidney.
authors.affiliation: Institute of Physiology, University of Regensburg Regensburg, Germany.
authors.forename: Bjoern
authors.initials: B
authors.lastname: Neubauer
authors.forename: Katharina
authors.initials: K
authors.lastname: Machura
authors.forename: Verena
authors.initials: V
authors.lastname: Rupp
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Tallquist
authors.forename: Christer
authors.initials: C
authors.lastname: Betsholtz
authors.forename: Maria Luisa S
authors.initials: ML
authors.lastname: Sequeira-Lopez
authors.forename: R
authors.initials: R
authors.lastname: Ariel Gomez
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wagner
keywords: Mural cells; PDGF-B; PDGF-β receptor; pericyte; renin