title: Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences.
abstract: Transcranial MRI-guided focused ultrasound (TcMRgFUS) is an old idea but a new technology that may change the entire clinical field of the neurosciences. TcMRgFUS has no cumulative effect, and it is applicable for repeatable treatments, controlled by real-time dosimetry, and capable of immediate tissue destruction. Most importantly, it has extremely accurate targeting and constant monitoring. It is potentially more precise than proton beam therapy and definitely more cost effective. Neuro-oncology may be the most promising area of future TcMRgFUS applications.
authors.affiliation: Division of MRI, National Center for Image-Guided Therapy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: jolesz@bwh.harvard.edu.
authors.forename: Ferenc A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: McDannold
mesh_terms: D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009488:Neurosciences / Q000379:methods / Q000639:trends; D019635:Neurosurgical Procedures / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D059708:Ultrasonic Surgical Procedures / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods
keywords: Blood-brain-barrier; Brain tumor; Chemotherapy; Focused ultrasound; Magnetic resonance imaging; Neuromodulation; Neurosurgery; Targeted drug delivery