title: Point-to-axial chirality transfer--a new probe for "sensing" the absolute configurations of monoamines.
abstract: A host molecule, capable of freely adopting P or M helicity, is described for molecular recognition and chirality sensing. The host, consisting of a biphenol core, binds chiral amines via hydrogen-bonding interactions. The diastereomeric complex will favor either P or M helicity as a result of minimizing steric interactions of the guest molecule with the binding cavity of the host, resulting in a detectable exciton-coupled circular dichroic spectrum. A working model is proposed that enables non-empirical prediction of the chirality of the bound amine.
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Mercy
authors.initials: M
authors.lastname: Anyika
authors.forename: Hadi
authors.initials: H
authors.lastname: Gholami
authors.forename: Kumar D
authors.initials: KD
authors.lastname: Ashtekar
authors.forename: Robert
authors.initials: R
authors.lastname: Acho
authors.forename: Babak
authors.initials: B
authors.lastname: Borhan