title: Study of antitumor activity of antibodies to TNF-α on Walker carcinosarcoma model.
abstract: The effect of release-active antibodies to TNF-α (Artrofoon) on the development of Walker carcinosarcoma 256 was studied in Wistar rats. Intragastric dose of this drug significantly inhibited the growth of tumor node (55% inhibition of tumor growth), but less effectively than the reference drug cyclophosphamide (80%). The studied drug significantly prolonged animal' lifespan (+97%) and its efficiency in this respect was comparable to that of cyclophosphamide (+96%).
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Materia Medica Holding, Moscow, Russia. JurlovaEI@materiamedica.ru.
authors.forename: E I
authors.initials: EI
authors.lastname: Yurlova
authors.forename: S G
authors.initials: SG
authors.lastname: Krylova
authors.forename: J L
authors.initials: JL
authors.lastname: Dugina
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D058956:Administration, Mucosal; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000276:immunology; D008136:Longevity / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D047368:Tumor Burden / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide