title: A systems neuroscience approach to the pathophysiology of pediatric mood and anxiety disorders.
abstract: Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments. The chapter concludes with directions for future research.
authors.affiliation: Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD, 20892, USA, wan-ling.tseng@nih.gov.
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Tseng
authors.forename: Ellen
authors.initials: E
authors.lastname: Leibenluft
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Brotman
mesh_terms: D001008:Anxiety Disorders / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D004644:Emotions / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D019964:Mood Disorders / Q000473:pathology / Q000503:physiopathology*; D012201:Reward