title: Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study.
abstract: BACKGROUND
  The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.
  
  
  METHODS
  We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case-control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking.
  
  
  RESULTS
  Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer.
  
  
  CONCLUSIONS
  A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.
authors.affiliation: Centre for Research in Epidemiology and Population Health (CESP), Inserm U1018, Epidemiology of Occupational and Social Determinants of Health Team, F-94807 Villejuif, France. daniele.luce@inserm.fr.
authors.forename: Loredana
authors.initials: L
authors.lastname: Radoï
authors.forename: Sophie
authors.initials: S
authors.lastname: Paget-Bailly
authors.forename: Florence
authors.initials: F
authors.lastname: Guida
authors.forename: Diane
authors.initials: D
authors.lastname: Cyr
authors.forename: Gwenn
authors.initials: G
authors.lastname: Menvielle
authors.forename: Annie
authors.initials: A
authors.lastname: Schmaus
authors.forename: Matthieu
authors.initials: M
authors.lastname: Carton
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cénée
authors.forename: Marie
authors.initials: M
authors.lastname: Sanchez
authors.forename: Anne-Valérie
authors.initials: AV
authors.lastname: Guizard
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücker
authors.forename: Danièle
authors.initials: D
authors.lastname: Luce
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology*; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects