title: [The role of regional intra-arterial chemotherapy in the combined treatment of locally advanced laryngeal cancer].
abstract: The objective of the present study was to estimate the possibilities and prospects for the use of regional intra-arterial chemotherapy in the combined treatment of locally advanced laryngeal cancer. The results of the chemoradiotherapeutic treatment of 26 patients presenting with locally advanced laryngeal cancer were analysed. The chemical agents were selectively administered intra-arterially three times from the right-hand femoral access by the standard procedure at a total focal dose (TFD) of 26 and 50 gram prior to the onset of and during of radiotherapy. The very first administration of the chemical agent resulted in the 30% decrease the tumour size. It further decreased by 70% on the average after the TFD of 50 gram was achieved. It made possible the continuation of gamma-therapy up to the total therapeutic dose. As a result, complete regression of the tumour was documented. The dynamic endoscopic control study and CT of the larynx revealed recurrent laryngeal cancer in 1 of the 26 patients (3.8%). The remaining patients did not develop metastases during the 18 month follow-up period. It is concluded that the results of the present study confirm high (96.2%) effectiveness of the method employed in this study which allows it to be recommended for the organ-preserving treatment of locally advanced laryngeal cancer.
authors.forename: T A
authors.initials: TA
authors.lastname: Mashkova
authors.forename: M S
authors.initials: MS
authors.lastname: Ol'shanskiĭ
authors.forename: I G
authors.initials: IG
authors.lastname: Panchenko
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Ovsiannikov
authors.forename: A B
authors.initials: AB
authors.lastname: Mal'tsev
mesh_terms: D000368:Aged; D000792:Angiography; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents