title: New insights in risk stratification of differentiated thyroid cancer.
abstract: OBJECTIVE
  Numerous staging and scoring systems exist for differentiated thyroid cancer (DTC), but all harbor limitations. This has prompted investigation for new factors with prognostic implications for DTC.
  
  
  RESULTS
  Several new factors that may be involved in DTC risk stratification have emerged, such as thyroid stimulating hormone and molecular markers. In addition, others are controversial and being challenged, such as age, sex and lymph node involvement.
  
  
  CONCLUSIONS
  The purpose of this review is to present recent updates in the literature on new potential risk stratification predictors for DTC.
authors.affiliation: aDivision of Metabolism, Endocrinology and Diabetes bDivision of Metabolism, Endocrinology and Diabetes, and Hematology/Oncology, Department of Medicine, Ann Arbor, Michigan, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Papaleontiou
authors.forename: Megan R
authors.initials: MR
authors.lastname: Haymart
mesh_terms: D000367:Age Factors; D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009367:Neoplasm Staging / Q000379:methods; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D013972:Thyrotropin / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D013972:Thyrotropin