title: The two faces of hydrogen-bond strength on triple AAA-DDD arrays.
abstract: Systems that are connected through multiple hydrogen bonds are the cornerstone of molecular recognition processes in biology, and they are increasingly being employed in supramolecular chemistry, specifically in molecular self-assembly processes. For this reason, the effects of different substituents (NO2, CN, F, Cl, Br, OCH3 and NH2) on the electronic structure, and consequently on the magnitude of hydrogen bonds in triple AAA-DDD arrays (A=acceptor, D=donor) were evaluated in the light of topological [electron localization function (ELF) and quantum theory of atoms in molecules (QTAIM)], energetic [Su-Li energy-decomposition analysis (EDA) and natural bond orbital analysis (NBO)], and geometrical analysis. The results based on local H-bond descriptors (geometries, QTAIM, ELF, and NBO) indicate that substitutions with electron-withdrawing groups on the AAA module tend to strengthen, whereas electron-donating substituents tend to weaken the covalent character of the AAA-DDD intermolecular H-bonds, and also indicate that the magnitude of the effect is dependent on the position of substitution. In contrast, Su-Li EDA results show an opposite behavior when compared to local H-bond descriptors, indicating that electron-donating substituents tend to increase the magnitude of H-bonds in AAA-DDD arrays, and thus suggesting that the use of local H-bond descriptors describes the nature of H bonds only partially, not providing enough insight about the strength of such H bonds.
authors.affiliation: Department of Chemistry, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-900 (Brazil), Fax: (+55) 48-3721-6852.
authors.forename: Alfredo Henrique Duarte
authors.initials: AH
authors.lastname: Lopez
authors.forename: Giovanni Finoto
authors.initials: GF
authors.lastname: Caramori
authors.forename: Daniel Fernando
authors.initials: DF
authors.lastname: Coimbra
authors.forename: Renato Luis Tame
authors.initials: RL
authors.lastname: Parreira
authors.forename: Éder Henrique
authors.initials: ÉH
authors.lastname: da Silva
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D004095:Dihydropyridines / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D004095:Dihydropyridines; D009287:Naphthyridines; D006859:Hydrogen
keywords: hydrogen bonding; natural bond orbital theory; quantum theory of atoms in molecules; self-assembly; topology