title: Single-dose oral toxicity of fermented scutellariae radix extract in rats and dogs.
abstract: The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu- 100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.
authors.affiliation: Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheung, Korea.
authors.forename: Myoung-Seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Seoung-Ho
authors.initials: SH
authors.lastname: Ham
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Jin
authors.initials: J
authors.lastname: Oh
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Kim
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: Beom-Su
authors.initials: BS
authors.lastname: Jang
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Cho
keywords: Dog; Rat; Scutellariae Radix; Single oral toxicity