title: Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis - a clinical evaluation.
abstract: OBJECTIVE
  To develop a low-dose controlled-release delivery system for the treatment of periodontal infections. A new sustained release drug system of Poly e-caprolactone (PCL) nanofibers containing doxycycline (DOX) was successfully electrospun and evaluated clinically for periodontal diseases. The retentive doxycycline nanofibres were shown to provide a controlled delivery of the drug.
  
  
  METHODS
  Nanofibers were prepared with DOX in PCL by electrospinning technique. The drug-coated nanofibres provided sustained effect up to a period of 11 days (264 h) and followed first order release. Forty sites in 7 patients (4 females and 3 males) with chronic periodontitis (5-8mm probing depth) were allocated in 2 experimental treatment groups, Group A-SRP (Scaling and Root Planing) + DOX nanofibers and Group B -SRP (Scaling and Root Planing) alone (control group). All these patients were evaluated clinically for probing depth (PD), plaque index (PI) and gingival index (GI).
  
  
  RESULTS
  Both the treatment groups were found to be efficacious in the treatment of periodontal disease as demonstrated by improvement in PD, PI and GI.
  
  
  CONCLUSIONS
  Combination of SRP (Scaling and Root Planing) + DOX nanofibers (Group A) resulted in added benefits compared to the control group.
authors.affiliation: Professor and Head, Faculty of Dental Sciences, I.M.S, Banaras Hindu University , Varanasi- 221005, Uttar Pradesh, India .
authors.forename: T P
authors.initials: TP
authors.lastname: Chaturvedi
authors.forename: Ruchi
authors.initials: R
authors.lastname: Srivastava
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Varun
authors.initials: V
authors.lastname: Gupta
authors.forename: Pushpendra Kumar
authors.initials: PK
authors.lastname: Verma
keywords: Chronic periodontitis; Doxycycline; Nanofibers; Poly e-caprolactone