title: Patterned friction and cell attachment on schizophobic polyelectrolyte surfaces.
abstract: A series of copolyelectrolytes with randomly positioned fluorinated (hydrophobic) and zwitterionic (hydrophilic) repeat units was synthesized and used to assemble multilayers. Regular layer-by-layer growth was observed for polymers with a charge density as low as 6%. The hydrophobicity of these "schizophobic" surfaces increased with increasing fluorine content. Polymer-on-polymer stamping was used to create patterned areas of low and high friction, probed by lateral force microscopy using a modified hydrophobic tip. "Contractile" A7r5 smooth muscle cells adhered to the fluorinated surfaces, but the introduction of zwitterion functionality induced a motile, less firmly attached morphology consistent with the "synthetic" motile phenotype of this cell line. In contrast with cells well adhered (on fluorinated) or completely nonadhering (on zwitterionic) films, incorporation of closely spaced repeat units with strongly contrasting hydrophobicity appears to generate intermediate cell adhesion behavior.
authors.affiliation: Department of Physical Sciences, West Virginia University Institute of Technology , Montgomery, West Virginia, 25136, United States.
authors.forename: Rana M
authors.initials: RM
authors.lastname: Jisr
authors.forename: Thomas C S
authors.initials: TC
authors.lastname: Keller
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Schlenoff
mesh_terms: D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D017276:Friction; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011108:Polymers