title: Update on the OMERACT magnetic resonance imaging task force: research and future directions.
abstract: Magnetic resonance imaging (MRI) provides an important biomarker across a range of rheumatological diseases. At the Outcome Measures in Rheumatology (OMERACT) 11 meeting, the MRI task force continued its work of developing and improving the use of MRI outcomes for use in clinical trials. The breadth of pathology in the Rheumatoid Arthritis MRI Score has been strengthened with further work on the development of a joint space narrowing score, and a series of exercises presented at OMERACT 11 demonstrated good reliability and construct validity for this assessment. Understanding the importance of residual inflammation after RA treatment remains a major focus of the group's work. Analyses were presented on defining the level of synovitis (using MRI scores of a single hand) that would predict absence of erosion progression. The development of the OMERACT Hand Osteoarthritis MRI score has continued with substantial work presented on its iterative development, including pathology definition, scaling, and subsequent reliability of the score. Optimizing the role of MRI as a robust biomarker and surrogate outcome remains a priority for this group.
authors.affiliation: From the Section of Musculoskeletal Disease, University of Leeds, and the UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand; University of NSW, Sydney, Australia; Spire Sciences LLC, San Francisco, California, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Rheumatology, Pitie Salpetriere Hospital, APHP, Université Paris 6-UPMC, Paris, France; Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Glostrup University Hospital, Copenhagen, Denmark; Department of Rheumatology, Slagelse Hospital, Slagelse, Denmark; Department of Radiology, Charité University Hospital, Berlin, Germany; Department of Rheumatology, St. George Hospital, University of NSW, Australia; Department of Radiology, Chapel Allerton Hospital, Leeds, UK; Medicine and Orthopaedics, University of California San Francisco, San Francisco, California, USA; Department of Rheumatology, Copenhagen University Hospital at Glostrup, Denmark.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McQueen
authors.forename: Paul
authors.initials: P
authors.lastname: Bird
authors.forename: Charles
authors.initials: C
authors.lastname: Peterfy
authors.forename: Espen
authors.initials: E
authors.lastname: Haavardsholm
authors.forename: Frédérique
authors.initials: F
authors.lastname: Gandjbakhch
authors.forename: Iris
authors.initials: I
authors.lastname: Eshed
authors.forename: Ida K
authors.initials: IK
authors.lastname: Haugen
authors.forename: Siri
authors.initials: S
authors.lastname: Lillegraven
authors.forename: Uffe Møller
authors.initials: UM
authors.lastname: Døhn
authors.forename: Bo
authors.initials: B
authors.lastname: Ejbjerg
authors.forename: Violaine
authors.initials: V
authors.lastname: Foltz
authors.forename: Laura
authors.initials: L
authors.lastname: Coates
authors.forename: Pernille
authors.initials: P
authors.lastname: Bøyesen
authors.forename: Kay-Geert
authors.initials: KG
authors.lastname: Hermann
authors.forename: Jane
authors.initials: J
authors.lastname: Freeston
authors.forename: Marissa
authors.initials: M
authors.lastname: Lassere
authors.forename: Philip
authors.initials: P
authors.lastname: O'Connor
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
authors.forename: Harry
authors.initials: H
authors.lastname: Genant
authors.forename: Mikkel
authors.initials: M
authors.lastname: Østergaard
mesh_terms: D001172:Arthritis, Rheumatoid / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010003:Osteoarthritis / Q000473:pathology*; D017063:Outcome Assessment, Health Care; D015203:Reproducibility of Results; D012219:Rheumatology; D012720:Severity of Illness Index; D013585:Synovitis / Q000473:pathology*
keywords: HAND OSTEOARTHRITIS; JOINT SPACE NARROWING; MAGNETIC RESONANCE IMAGING