title: Synthesis of C-13-labeled atrazine.
abstract: Atrazine is a long-lasting herbicide that has been shown to affect hormone levels in amphibians. Using the C-13 labeled atrazine to detect its residue is effective and essential. This study presents three steps for the synthesis of [(13) C3 ]atrazine, which starts from [(13) C]urea, and results in the incorporation of C-13 atoms at the 1, 3 and 5 positions of the S-triazine ring of atrazine. The method prepares the product in an overall yield of 57.6% and chemical purity of 98.6%, for use as an internal standard.
authors.affiliation: State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institution of Plant Protection-Pesticide, Beijing, 100193, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Chen
authors.forename: Dejie
authors.initials: D
authors.lastname: Lin
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Beibei
authors.initials: B
authors.lastname: Gao
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Mei
authors.forename: Jun
authors.initials: J
authors.lastname: Ning
authors.forename: Dongmei
authors.initials: D
authors.lastname: She
mesh_terms: D001280:Atrazine / Q000138:chemical synthesis*; D002247:Carbon Isotopes / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D002247:Carbon Isotopes; D001280:Atrazine
keywords: C-13; atrazine synthesis; cyanuric acid; cyanuric chlorine; internal standards; isotopically labeled synthesis