title: Differences in coagulation between hemodialysis and peritoneal dialysis.
abstract: BACKGROUND
  End-stage renal disease patients have significant cardiovascular morbidity and mortality, but little is known about differences in coagulation profiles between patients on hemodialysis (HD) and on peritoneal dialysis (PD). Given their long-term exposure to glucose-based dialysate, patients on PD can experience metabolic derangements. Theoretically, that exposure should create a more prothrombotic environment than occurs in HD patients. The objective of the present study was to quantify potential differences in baseline coagulation between PD and HD patients. ♢
  
  
  METHODS
  Our single-center cross-sectional study at a large academic health science center enrolled 50 age-, race-, and sex-matched subjects (10 control subjects, 20 HD patients, and 20 PD patients). Measurements included platelet function, platelet receptor distribution, and coagulation dynamics by thromboelastography and Hemodyne hemostasis assay (Hemodyne, Richmond, VA, USA). ♢
  
  
  RESULTS
  Compared with healthy control subjects, patients on both forms of dialysis showed prothrombotic coagulation protein profiles. The tissue-factor pathway was markedly elevated in both groups, but PD was associated with significantly greater concentrations of tissue factor (p = 0.0056) and tissue-factor pathway inhibitor (p = 0.0138). Similarly, compared with patients receiving HD, patients on PD had greater concentrations of fibrinogen (p = 0.0325), which corresponded with platelet hyperfunction as measured by platelet contractile force and clot elastic modulus (p = 0.003 and 0.017 respectively, compared with values in HD patients). Platelet receptor distribution was similar between the groups. ♢
  
  
  CONCLUSIONS
  Compared with patients on HD, patients on PD appear to have a more prothrombotic profile. The clinical relevance of these findings needs to be studied in a prospective manner.
authors.affiliation: Division of Nephrology,1 Department of Internal Medicine, Virginia Commonwealth University (VCU) School of Medicine;
authors.forename: Donald F
authors.initials: DF
authors.lastname: Brophy
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Carl
authors.forename: Bassem M
authors.initials: BM
authors.lastname: Mohammed
authors.forename: Jingmei
authors.initials: J
authors.lastname: Song
authors.forename: Erika J
authors.initials: EJ
authors.lastname: Martin
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Bostic
authors.forename: Todd W B
authors.initials: TW
authors.lastname: Gehr
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010865:Pilot Projects; D006435:Renal Dialysis
keywords: Hemodialysis; coagulation