title: Assessing resistance of ivermectin and moxidectin against nematodes in cattle naturally infected using three different methodologies.
abstract: The objective of this study was to evaluate the accuracy of the faecal egg count reduction test (FECRT) and the faecal egg count efficacy test (FECET) to assess the resistance status of ivermectin (630 μg/kg) and moxidectin (200 μg/kg), using the controlled efficacy test as a reference, and whether the results of the EPG are equivalent to the efficacy results from the parasitological necropsies. Two experiments were conducted. The results demonstrate that it was not possible to demonstrate that the EPG values were equivalent with the ivermectin and moxidectin efficacy obtained by parasitological necropsies, mainly if the phenomenon of parasites resistance is not advanced in a determined field population. Maybe the FECET technique would be possibly better than the FECRT. The high anthelmintic efficacy of 200 μg/kg moxidectin, in naturally infected cattle, against field population of nematodes that are resistant to 630 μg/kg ivermectin, was observed in this study.
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil. Electronic address: wdzlopes@hotmail.com.
authors.forename: Welber Daniel Zanetti
authors.initials: WD
authors.lastname: Lopes
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Weslen Fabricio Pires
authors.initials: WF
authors.lastname: Teixeira
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Felippelli
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Breno Cayeiro
authors.initials: BC
authors.lastname: Cruz
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Willian Giquelin
authors.initials: WG
authors.lastname: Maciel
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil; UNICASTELO - Universidade Camilo Castelo Branco, Brazil.
authors.forename: Vando Edésio
authors.initials: VE
authors.lastname: Soares
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Thais Rabelo
authors.initials: TR
authors.lastname: dos Santos
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Lucas Vinicius Shigaki
authors.initials: LV
authors.lastname: de Matos
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Flávia Carolina
authors.initials: FC
authors.lastname: Fávero
authors.affiliation: CPPAR, Animal Health Research Center, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Via de acesso prof. Paulo Donatto Castellani, s/n CEP: 14884-900, Jaboticabal, São Paulo, Brazil.
authors.forename: Alvimar José
authors.initials: AJ
authors.lastname: da Costa
mesh_terms: D000818:Animals; D001938:Brazil; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018942:Macrolides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D009348:Nematoda / Q000254:growth & development*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000379:methods / Q000592:standards / Q000662:veterinary; D011897:Random Allocation
chemical_list: D018942:Macrolides; D007559:Ivermectin; C027837:moxidectin
keywords: Anthelmintic; Cattle; Ivermectin; Moxidectin; Resistance