title: Contribution of long noncoding RNAs to autism spectrum disorder risk.
abstract: Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. We review here the known functions of lncRNAs and the potential contributions of lncRNAs to ASD.
authors.affiliation: Program in Biological and Biomedical Sciences, University of Southern California, Los Angeles, California, USA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
authors.forename: Brent
authors.initials: B
authors.lastname: Wilkinson
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Campbell
mesh_terms: D002659:Child Development Disorders, Pervasive / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Biomarkers; Epigenetics; Gene regulation; Long noncoding RNA; Noncoding RNA; Transcriptional regulation; lncRNA; ncRNA