title: Sequence control in polymer chemistry through the Passerini three-component reaction.
abstract: A new strategy to achieve sequence control in polymer chemistry based on the iterative application of the versatile Passerini three-component reaction (P-3CR) in combination with efficient thiol-ene addition reactions is introduced. First, stearic acid was used as a starting substrate to build up a sequence-defined tetramer with a molecular weight of 1.6 kDa. Using an acid-functionalized PEG allowed for an easier isolation of the sequence-defined macromolecules by simple precipitation and led to a sequence-defined pentamer in a block-copolymer architecture. Importantly, this new strategy completely avoids protecting group chemistry. By following this strategy, a different side chain can be introduced to the polymer/oligomer backbone in a simple way and at a defined position within the macromolecule.
authors.affiliation: Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany) http://www.meier-michael.com.
authors.forename: Susanne C
authors.initials: SC
authors.lastname: Solleder
authors.forename: Michael A R
authors.initials: MA
authors.lastname: Meier
keywords: Passerini reactions; block copolymers; defined polymers; multicomponent reactions; sequence control