title: Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.
abstract: The aim of the present study was to examine the effects of green tea epigallocatechin-3-gallate (EGCG) on changes in body composition, energy and substrate metabolism, cardiometabolic risk factors and liver function enzymes after an energy-restricted diet intervention in obese women. In the present randomised, double-blind, placebo-controlled study, eighty-three obese (30 kg/m² > BMI < 40 kg/m²) pre-menopausal women consumed 300 mg/d of EGCG or placebo (lactose). We measured body weight and adiposity (dual-energy X-ray absorptiometry), energy expenditure and fat oxidation rates (indirect calorimetry), blood lipid levels (TAG, total cholesterol, LDL-cholesterol and HDL-cholesterol), insulin resistance, C-reactive protein and liver function markers (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, urea, bilirubin and 2-keto[1-¹³C]isocaproate oxidation) before and after the intervention in the EGCG and control groups. We did not find any significant difference in the changes in body weight (-0.3 kg, 95% CI -5.0, 4.3), fat mass (-0.7 kg, 95% CI -3.5, 2.1), energy (0.3 kJ/kg per d, 95% CI -3.1, 2.7) and fat (-0.1 g/min, 95% CI -0.03, 0.01) metabolism, homeostasis assessment model for insulin resistance (0.2, 95% CI -0.2, 0.7), total cholesterol (-0.21 mmol/l, 95% CI -0.55, 0.13), LDL-cholesterol (-0.15 mmol/l, 95% CI -0.50, 0.20), TAG (-0.4 mmol/l, 95% CI -0.56, 0.29) and liver function markers between the EGCG and control groups. In conclusion, the present results suggest that dietary supplementation with 300 mg/d of EGCG for 12 weeks did not enhance energy-restricted diet-induced adiposity reductions, and did not improve weight-loss-induced changes in cardiometabolic risk factors in obese Caucasian women. The intake of 300 mg/d of EGCG for 12 weeks did not cause any adverse effect on liver function biomarkers.
authors.affiliation: Department of Nutrition and Food Sciences, University of the Basque Country, UPV/EHU, Vitoria, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Mielgo-Ayuso
authors.affiliation: Department of Medicine, University of the Basque Country, Vitoria, Spain.
authors.forename: Lurdes
authors.initials: L
authors.lastname: Barrenechea
authors.affiliation: Department of Nuclear Medicine, Hospital of Santiago Apóstol, UPV/EHU, Vitoria, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Alcorta
authors.affiliation: Biomedical Research Area, Tecnalia, Miñano, Spain.
authors.forename: Eider
authors.initials: E
authors.lastname: Larrarte
authors.affiliation: Biomedical Research Area, Tecnalia, Miñano, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Margareto
authors.affiliation: Department of Nutrition and Food Sciences, University of the Basque Country, UPV/EHU, Vitoria, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Labayen
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000975:Antioxidants / Q000009:adverse effects / Q000627:therapeutic use*; D015992:Body Mass Index; D028241:Camellia sinensis / Q000737:chemistry; D002392:Catechin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004038:Diet, Reducing; D019587:Dietary Supplements; D004311:Double-Blind Method; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D010936:Plant Extracts; D002392:Catechin; C045651:epigallocatechin gallate