title: Induced pluripotent stem cells (iPSc) for gene therapy.
abstract: The generation of autologous pluripotent stem cells by reprogramming and then their differentiation into any cell type is a very attractive prospect for biomedicine. Additionally, if it were possible to repair malfunctioning genes it would mean that there is hope for patients suffering from incurable diseases in which conventional treatment does not give satisfactory results. Data from animal models are promising. But there are still issues that must be solved, such as the low efficiency of the derivation of induced pluripotent cells, and most importantly, making sure that the techniques used both for reprogramming cells, as well as for gene therapy are safe.
authors.affiliation: Department of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland, 0048 572-09-65, maciej.malecki@wum.edu.pl.
authors.forename: Ilona
authors.initials: I
authors.lastname: Szabłowska-Gadomska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Górska
authors.forename: Maciej
authors.initials: M
authors.lastname: Małecki
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation*; D023421:Models, Animal