title: Influence of family history on survival in patients with colon and rectal cancer.
abstract: OBJECTIVE
  We aimed to investigate the association between a family history (FH) of colorectal cancer (CRC) and cancer recurrence and survival in patients with stage III CRC.
  
  
  METHODS
  From April 2001 to December 2007, 1102 patients with stage III CRC were enrolled and their data including FH, clinicopathological characteristics of the tumor were retrospectively analyzed.
  
  
  RESULTS
  Of 971 patients that were finally enrolled, 63 (6.5%) reported CRC in at least one first-degree relative. Death occurred in 12.7% of the CRC patients with an FH and 21.8% in those without an FH. A multivariate analysis showed that patients with an FH of CRC, compared with those without FH, had an adjusted hazard ratios (HR) of 0.674 (P = 0.281) for overall survival (OS) and 0.672 (P = 0.220) for disease-free survival (DFS). However, the location of tumor, preoperative carcinoembryonic antigen (CEA) level, tumor invasion (T) stage and lymph node (N) metastasis significantly affected OS and DFS. Furthermore, whereas the FH of CRC patients was associated with a favorable prognosis in stage III colon cancer (HR 0.224, P = 0.040) but not in rectal cancer (HR 1.225, P = 0.640).
  
  
  CONCLUSIONS
  In patients with stage III CRC, tumor location (especially in the rectum), a high preoperative CEA level and advanced T and N stages indicate a poor prognosis. However, in stage III colon cancer FH is associated with improved survival.
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
authors.forename: Seong Dae
authors.initials: SD
authors.lastname: Lee
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.forename: Sung Chan
authors.initials: SC
authors.lastname: Park
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Baek
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Chang
authors.forename: Dae Yong
authors.initials: DY
authors.lastname: Kim
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002272:Carcinoembryonic Antigen
keywords: colon cancer; family history; prognosis; rectal cancer; survival