title: Cyclopentane peptide nucleic acids.
abstract: Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
authors.affiliation: Section on Synthetic Bioactive Molecules, Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Englund
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Appella
mesh_terms: D001483:Base Sequence; D003517:Cyclopentanes / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000235:genetics
chemical_list: D003517:Cyclopentanes; D020135:Peptide Nucleic Acids