title: The role of bacterial phytotoxins in inhibiting the eukaryotic proteasome.
abstract: The ubiquitin-26S proteasome degradation system (UPS) plays a pivotal role in almost all aspects of plant life, including defending against pathogens. Although the proteasome is important for plant immunity, it has been found to be also exploited by pathogens using effectors to increase their virulence. Recent work on the XopJ effector and syringolin A/syrbactins has highlighted host proteasome inhibition as a virulence strategy of pathogens. This review will focus on these recent developments.
authors.affiliation: Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, CH-8008 Zurich, Switzerland. Electronic address: rdudler@botinst.uzh.ch.
authors.forename: Robert
authors.initials: R
authors.lastname: Dudler
mesh_terms: D001419:Bacteria / Q000254:growth & development* / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000378:metabolism*; D010944:Plants / Q000187:drug effects* / Q000382:microbiology*; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects* / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D037521:Virulence Factors; D046988:Proteasome Endopeptidase Complex
keywords: proteasome inhibitor; syrbactin; syringolin; type III effectors; virulence factor