title: Use of stem cells in heart failure treatment: where we stand and where we are going.
abstract: End-stage heart failure is the final common pathway of an irreversible process associated with loss of myocardial cells. In this process, the capacity for renewal and repair of myocardial tissue is inadequate and ultimately leads to ventricular remodeling. Novel therapeutic strategies have been developed to prevent it, one being cell therapy, which has emerged as a potential approach to directly repopulate and repair the damaged heart. Here, we review the use of regenerative cell therapy for different cardiac diseases and discuss the positive effect of cell therapy mediated by paracrine factors instead of turning directly into cardiomyocytes.
authors.affiliation: Cátedra de Cardiología y Medicina Vascular, Escuela de Medicina, Tecnológico de Monterrey, Monterrey, México.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Sánchez
authors.forename: Carlos Enrique
authors.initials: CE
authors.lastname: Guerrero-Beltrán
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Cordero-Reyes
authors.forename: Gerardo
authors.initials: G
authors.lastname: García-Rivas
authors.forename: Guillermo
authors.initials: G
authors.lastname: Torre-Amione
mesh_terms: D001854:Bone Marrow Cells; D002311:Cardiomyopathy, Dilated / Q000628:therapy*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D044968:Regenerative Medicine / Q000639:trends*; D033581:Stem Cell Transplantation / Q000639:trends*
keywords: bone marrow-derived cell therapy; cardiac stem cell therapy; dilated cardiomyopathy; heart failure