title: Acute toxicity and genotoxic activity of avocado seed extract (Persea americana Mill., c.v. Hass).
abstract: The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.
authors.affiliation: Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Padilla-Camberos
authors.forename: Moisés
authors.initials: M
authors.lastname: Martínez-Velázquez
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Flores-Fernández
authors.forename: Socorro
authors.initials: S
authors.lastname: Villanueva-Rodríguez
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D027421:Persea / Q000737:chemistry*; D010936:Plant Extracts / Q000633:toxicity*; D012639:Seeds / Q000737:chemistry; D023382:Toxicity Tests, Acute / Q000379:methods
chemical_list: D010936:Plant Extracts