title: [Local therapy of infectious complications of allergic rhinitis in the children].
abstract: The objective of the present investigation was to estimate the effectiveness and safety of rinorin used for the prevention and treatment of infectious complications of allergic rhinitis in the children. A total of 70 children varying in the age from 5 to 15 years and presenting with the mild and moderate-to-severe form of seasonal allergic rhinitis were included in the study; they were divided into two groups. The study failed to reveal statistically significant difference between the groups in terms of adverse reactions to the treatment with rinorin. During the 21 day study period, infectious rhinitis was diagnosed in 2 (5.7%) children given rinorin compared with 5 (14.3%) ones in the control group (p>0.05). However, the patients of the latter group suffered a more severe form of this infectious complication of allergic rhinitis. It is concluded that rinorin is characterized by a high level of safety even though the antimicrobial potency of benzalkonium chloride, its active ingredient, needs further studies and evaluation.
authors.forename: E P
authors.initials: EP
authors.lastname: Karpova
authors.forename: D A
authors.initials: DA
authors.lastname: Tulupov
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001548:Benzalkonium Compounds / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications* / Q000188:drug therapy; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds