title: Analysis of purine metabolites in maternal serum for evaluating the risk of gestosis.
abstract: Metabolome analysis of the serum from pregnant patients aimed at detection of low-molecular-weight biomarkers of gestation process disorders indicated a relationship between the metabolic profile of maternal serum and risk of gestosis. In women with pre-eclampsia or preterm delivery, analysis of serum purine metabolites revealed changes in the metabolite concentrations, associated with pregnancy complications.
authors.affiliation: BioClinicum Center; V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. senyavina@physics.msu.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Senyavina
authors.forename: S A
authors.initials: SA
authors.lastname: Khaustova
authors.forename: T K
authors.initials: TK
authors.lastname: Grebennik
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlovich
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D056148:Chromatography, Reverse-Phase; D005260:Female; D005865:Gestational Age; D006801:Humans; D019271:Hypoxanthine / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011247:Pregnancy; D012306:Risk; D014527:Uric Acid / Q000097:blood*; D019820:Xanthine / Q000097:blood*
chemical_list: D015415:Biomarkers; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine