title: [The association of indicators of serum lipids and bile in individuals with the family history, burdened by a bile stone disease].
abstract: OBJECTIVE
  To evaluate serum and bile lipids levels in persons with and without positive family history of gallstone disease (PFH GSD).
  
  
  METHODS
  165 people were surveyed: 71 people with PFH GSD and 94 persons without PFH GSD. was evaluated: in serum--total cholesterol--TCh, triglycerides--TG, HDL, in the gallbladder bile--cholesterol (BCh), total bile acids (TBA), TBA/BCh coefficient (TBC), sialic (SA) and cholic acid (CA).
  
  
  RESULTS
  TCh (5.3 +/- 0.13 mmol/L), TG (2.1 +/- 0.13 mmol/L) blood serum levels and BCh (3.6 +/- 0.2 g/l) were higher in persons with PFH GSD than in those without PFH GSD (4.8 +/- 0.1; 1.2 +/- 0.09 and 2.8 +/- 0.2, respectively), and HDL (1.0 +/- 0.04 mmol/L) and TBC levels (6.9 +/- 0.5 Units) in persons with PFH GSD were lower than in those without PFH GSD (1.5 +/- 0.03 and 9.3 +/- 0.8, respectively), p < 0.05 in all cases. TBA, SA and CA levels did not differ between two groups.
  
  
  CONCLUSIONS
  PFH GSD was associated with blood serum lipid profile (total cholesterol, triglycerides, HDL) and the composition of bile (bile cholesterol, TBA/BCh coefficient).
authors.forename: I N
authors.initials: IN
authors.lastname: Grigor'eva
authors.forename: M A
authors.initials: MA
authors.lastname: Slobodchikova
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism*; D005260:Female; D042882:Gallstones / Q000097:blood*; D030342:Genetic Diseases, Inborn / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male
chemical_list: D008055:Lipids