title: Emerging role of high-mobility group box 1 (HMGB1) in liver diseases.
abstract: Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP molecule. Recent research indicates that aberrant activation of HMGB1 signaling can promote the onset of inflammatory and autoimmune diseases, raising interest in the development of therapeutic strategies to control their function. The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review.
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Ruochan
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
authors.forename: Wen
authors.initials: W
authors.lastname: Hou
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
authors.forename: Rui
authors.initials: R
authors.lastname: Kang
authors.affiliation: Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Fan
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
authors.forename: Daolin
authors.initials: D
authors.lastname: Tang
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004195:Disease Models, Animal; D024243:HMGB1 Protein / Q000502:physiology*; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D024243:HMGB1 Protein