title: Reduced STMN1 expression induced by RNA interference inhibits the bioactivity of pancreatic cancer cell line Panc-1.
abstract: Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Suppression of STMN1 expression via transfection with STMN1-specific siRNA could not only significantly inhibit the proliferation, migration and invasion ability of Panc-1 cells, but also enhance the apoptosis of Panc-1 cells. In addition, downregulation of STMN1 obviously enhanced the acetylation level of α-tubulin. All these results indicated that STMN1 plays an important role in pancreatic cancer development, and might serve as a potential therapeutic target for pancreatic cancer.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: G H
authors.initials: GH
authors.lastname: Hu
authors.forename: F J
authors.initials: FJ
authors.lastname: Kong
authors.forename: K M
authors.initials: KM
authors.lastname: Wu
authors.forename: B
authors.initials: B
authors.lastname: He
authors.forename: K
authors.initials: K
authors.lastname: Song
authors.forename: W J
authors.initials: WJ
authors.lastname: Sun
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D034622:RNA Interference; D034741:RNA, Small Interfering; D050777:Stathmin / Q000235:genetics* / Q000378:metabolism
chemical_list: D034741:RNA, Small Interfering; C493995:STMN1 protein, human; D050777:Stathmin
keywords: pancreatic cancer, STMN1, Panc-1, RNA interference (RNAi), cancer therapy