title: [Identification of osteogenic signal and the development of artificial bones].
abstract: Mammalian skeletons are formed through two distinct processes, intramembranous ossification and endochondral ossification. During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and the layer of hypertrophic chondrocytes. Ihh also stimulates bone formation. Based on such knowledge, bioactive molecule-loaded artificial bones are expected to achieve efficient bone regeneration without cell transplantation.
authors.affiliation: Department of Bioengineering, The University of Tokyo Graduate School of Engineering, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ohba
authors.forename: Ung-il
authors.initials: UI
authors.lastname: Chung
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tei
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D002130:Calcium Phosphates; D019902:Chondrocytes / Q000473:pathology / Q000502:physiology; D004838:Epiphyses / Q000473:pathology / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D006984:Hypertrophy; D010012:Osteogenesis / Q000235:genetics* / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein / Q000502:physiology*; D019736:Prostheses and Implants / Q000639:trends*; D011474:Prosthesis Design / Q000639:trends*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology
chemical_list: D002130:Calcium Phosphates; D053823:Hedgehog Proteins; C509246:IHH protein, human; D044162:Parathyroid Hormone-Related Protein; C018392:tricalcium phosphate