title: Ultrasound diagnosis in two cases of severe craniofacial anomalies.
abstract: Holoprosencephaly (HPE) is a rare anomaly of the brain consisting of an absent or incomplete separation of the forebrain in early gestation. We present 2 variants of HPE, diagnosed by ultrasound, which combined with the clinical features led to HPE subtypes differentiation.
authors.affiliation: University of Medicine and Pharmacy "Carol Davila", 1st Pediatric Department Prof Dr "A.Rusescu", Bucharest,Romania; Email: ioanaalina@yahoo.com.
authors.forename: Mirela
authors.initials: M
authors.lastname: Ritivoiu
authors.forename: Florin
authors.initials: F
authors.lastname: Brezan
authors.forename: Ioana
authors.initials: I
authors.lastname: Codreanu
authors.forename: Mircea
authors.initials: M
authors.lastname: Stamate
authors.forename: Ioana
authors.initials: I
authors.lastname: Anca
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D015599:Trauma Severity Indices; D014463:Ultrasonography / Q000379:methods*