title: The Effect of Diluted Penetration Enhancer in Nebulized Mist versus Liquid Drop Preparation Forms on Retrobulbar Blood Flow in Healthy Human Subjects.
abstract: The aim of this study was to compare the effects of nebulized mist and liquid drop applications on retrobulbar blood flow. A prospective, non-randomized clinical trial was used to collect data from 40 healthy human eyes. Color Doppler Imaging determined peak systolic (PSV) and end diastolic (EDV) blood flow velocities and resistance index (RI) in the ophthalmic artery after both applications. Measurements were taken at baseline and at 1 min post-treatment in both eyes with 5 min measurements in the treatment eye only. p values ≤ 0.05 were considered statistically significant. Mist application to treatment eye produced an increase in 1 min and 5 min PSV and EDV (0.001 < p < 0.03) and a decrease in 5 min RI (p = 0.01), with no significant changes in PSV, EDV or RI of control eye or in treatment eye 1 min RI (p > 0.05). Drop application to treatment eye produced an increase in PSV (p < 0.001) and EDV (p = 0.01) at 1 min, with an increase in control eye 1 min PSV and EDV (p = 0.03). There were no statistically significant changes in treatment eye PSV, EDV and RI after 5 min (p > 0.05). The use of nebulized mist may provide an effective alternative to liquid drop medication application.
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. alharris@indiana.edu.
authors.forename: Sally
authors.initials: S
authors.lastname: Primus
authors.forename: Ingrida
authors.initials: I
authors.lastname: Januleviciene
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
authors.forename: Austin
authors.initials: A
authors.lastname: Gerber
authors.forename: Patrick
authors.initials: P
authors.lastname: Egan
authors.forename: Annahita
authors.initials: A
authors.lastname: Amireskandari
authors.forename: Lina
authors.initials: L
authors.lastname: Siaudvytyte
authors.forename: Ruta
authors.initials: R
authors.lastname: Barsauskaite
authors.forename: Alon
authors.initials: A
authors.lastname: Harris