title: Mutations in NSCLC and their link with lung cancer-associated thrombosis: a case-control study.
abstract: BACKGROUND
  The association of venous thromboembolic events (VTE) and lung cancer is highly prevalent. Additionally, the occurrence of a VTE with cancer has been associated with a worse prognosis and a poor quality of life. Underlying cancer biological features such as tumour mutations may contribute to VTE risk and cancer prognosis. Since preclinical data suggest a link between thrombosis and KRAS mutations in tumours, we aimed to validate this association in a patient registry cohort.
  
  
  METHODS
  A retrospective case control study was performed using the CHUM NSCLC registry. Cases had VTE occurring 6months previous to or after a diagnosis of NSCLC. Diagnosis of VTE (venous thrombosis, pulmonary embolism, and migratory superficial thrombophlebitis) was confirmed by a review of the imaging reports. Controls were patients with NSCLC without thrombosis matched for age and stage (I-IIIA/IIIB-IV). Exclusion criteria included insufficient tissue for KRAS/EGFR mutation analysis or insufficient clinical information.
  
  
  RESULTS
  Between Jan 2000 and Dec 2009 a total of 57 cases with VTE and 102 controls without VTE were included. The OR for thrombosis in KRAS and EGFR mutated NSCLC patients are respectively 2.67 (1.12-6.42; p=0.014) and 0.99 (0.27-3.48; p=0.99).
  
  
  CONCLUSIONS
  KRAS mutation is associated with an increased risk of VTE in this NSCLC cohort. These findings are consistent with preclinical studies. Prospective data on VTE rates from clinical trials with molecularly defined NSCLC are needed to confirm these findings.
authors.affiliation: Medical Oncologist, Grupo Costarricense contra el Cáncer/Hospital San Juan de Dios, CCSS San José, Costa Rica.
authors.forename: Luis
authors.initials: L
authors.lastname: Corrales-Rodriguez
authors.affiliation: Medical Oncologist/Hematologist, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Soulières
authors.affiliation: Medical Oncologist/Hematologist, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Xiaoduan
authors.initials: X
authors.lastname: Weng
authors.affiliation: Medical Oncologist/Hematologist, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Tehfe
authors.affiliation: Medical Oncologist/Hematologist, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Marie
authors.initials: M
authors.lastname: Florescu
authors.affiliation: Medical Oncologist/Hematologist, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. Electronic address: n.blais@umontreal.ca.
authors.forename: Normand
authors.initials: N
authors.lastname: Blais
mesh_terms: D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012189:Retrospective Studies; D013927:Thrombosis / Q000235:genetics*; D055815:Young Adult