title: Highly stable hexacoordinated nonoxidovanadium(IV) complexes of sterically constrained ligands: syntheses, structure, and study of antiproliferative and insulin mimetic activity.
abstract: Three highly stable, hexacoordinated nonoxidovanadium(IV), V(IV)(L)2, complexes (1-3) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N3O3 donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex 3 being the most potent, which is comparable to insulin at the complex concentration of 4 μM, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes 1-3 against the HeLa cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and 2 showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs.
authors.affiliation: Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India.
authors.forename: Subhashree P
authors.initials: SP
authors.lastname: Dash
authors.forename: Sagarika
authors.initials: S
authors.lastname: Pasayat
authors.forename: Saswati
authors.initials: S
authors.lastname: Bhakat
authors.forename: Satabdi
authors.initials: S
authors.lastname: Roy
authors.forename: Rupam
authors.initials: R
authors.lastname: Dinda
authors.forename: Edward R T
authors.initials: ER
authors.lastname: Tiekink
authors.forename: Subhadip
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Sujit K
authors.initials: SK
authors.lastname: Bhutia
authors.forename: Manasi R
authors.initials: MR
authors.lastname: Hardikar
authors.forename: Bimba N
authors.initials: BN
authors.lastname: Joshi
authors.forename: Yogesh P
authors.initials: YP
authors.lastname: Patil
authors.forename: M
authors.initials: M
authors.lastname: Nethaji
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D032701:Biomimetics; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D007328:Insulin / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D015394:Molecular Structure; D032446:Myoblasts; D014639:Vanadium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007328:Insulin; D008024:Ligands; D014639:Vanadium