title: [Recurrent Clostridium difficile infections: the importance of the intestinal microbiota].
abstract: Clostridium difficile infections (CDI) represent 20-30% of diarrhea caused by antibiotics and relapse in more than 25% of cases after treatment with metronidazole or vancomycin. Given the high prevalence of CDI and the significant rate of recurrence despite successful initial treatment, CDI therapy represents a real challenge. A better understanding of the intestinal microbiota and its role in CDI opens the way to promising new therapeutic approaches, such as fecal transplantation. The studies published to date, although few, conclude a certain effectiveness of fecal transplantation in recurrent CDI. Further studies are needed to confirm its effectiveness, determine the long-term consequences as well as good administration practices.
authors.affiliation: Service de médecine interne générale, Département de médecine interne, réhabilitation et gériatrie, HUG, 1211 Genève 14. marie-celine.zanella@hcuge.ch
authors.forename: Marie-Céline
authors.initials: MC
authors.lastname: Zanella Terrier
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Frossard
authors.forename: Martine Louis
authors.initials: ML
authors.lastname: Simonet
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D003967:Diarrhea / Q000382:microbiology / Q000628:therapy*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents