title: Central role of RET in thyroid cancer.
abstract: RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita' degli Studi di Napoli Federico II, 80131 Napoli, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Santoro
authors.forename: Francesca
authors.initials: F
authors.lastname: Carlomagno
mesh_terms: D002277:Carcinoma / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D018278:Carcinoma, Neuroendocrine; D002291:Carcinoma, Papillary; D006801:Humans; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D051096:Proto-Oncogene Proteins c-ret / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics
chemical_list: D047428:Protein Kinase Inhibitors; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human