title: Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans.
abstract: Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson's disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.
authors.affiliation: Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA. michael.aschner@einstein.yu.edu.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Julia
authors.initials: J
authors.lastname: Bornhorst
authors.forename: Thuy T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Michael
authors.initials: M
authors.lastname: Aschner
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000502:physiology; D009410:Nerve Degeneration / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics / Q000502:physiology; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000502:physiology; D000099202:PTEN-Induced Putative Kinase
chemical_list: D029742:Caenorhabditis elegans Proteins; D047908:Intracellular Signaling Peptides and Proteins; D051267:NF-E2-Related Factor 2; D015513:Oncogene Proteins; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C495635:NFE2L2 protein, human; C111567:parkin protein; C105131:PARK7 protein, human