title: Commentary in support of a highly effective hypertension treatment algorithm.
abstract: A simple hypertension treatment algorithm has contributed to the achievement of control rates greater than 85% for more than 1 million adults with hypertension across the United States. It is built on the fixed-dose combination drug lisinopril/hydrochlorothiazide, which is maximized in three steps before adding amlodipine. Spironolactone is the preferred fourth drug.
authors.affiliation: Kaiser Permanente, Anaheim, CA.
authors.forename: Joel
authors.initials: J
authors.lastname: Handler
mesh_terms: D000328:Adult; D000465:Algorithms; D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril / Q000627:therapeutic use*; D013148:Spironolactone / Q000627:therapeutic use*; D016896:Treatment Outcome; D014481:United States
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; C091365:hydrochlorothiazide, lisinopril drug combination; D006852:Hydrochlorothiazide; D017311:Amlodipine; D013148:Spironolactone; D017706:Lisinopril