title: Tandem synthesis of 3-allyl-chromones from alkynones and allylic alcohols under metal-free conditions.
abstract: A novel and efficient approach to 3-allyl-chromones from alkynones and allylic alcohols via a tandem Michael addition-Claisen rearrangement-O-arylation reaction has been developed. Diversely structural 3-allyl-chromones were afforded in up to 93% yield for 24 examples. This synthetic strategy is regiospecific, highly efficient, environment friendly and metal-free.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Wang
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D002867:Chromones; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium