title: Layer-by-layer assembly of silica nanoparticles on 3D fibrous scaffolds: enhancement of osteoblast cell adhesion, proliferation, and differentiation.
abstract: Silica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration.
authors.affiliation: Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3216, Australia.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xungai
authors.initials: X
authors.lastname: Wang
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
mesh_terms: D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D002448:Cell Adhesion; D002454:Cell Differentiation; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D011091:Polyesters / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D011091:Polyesters; C016240:polycaprolactone; D012822:Silicon Dioxide
keywords: 3D scaffolds; nanostructured surface; osteoblasts; tissue engineering