title: Multifunctional polypyrrole@Fe(3)O(4) nanoparticles for dual-modal imaging and in vivo photothermal cancer therapy.
abstract: Magnetic Fe3 O4 crystals are produced in situ on preformed polypyrrole (PPY) nanoparticles by rationally converting the residual Fe species in the synthetic system. The obtained PPY@Fe(3)O(4)composite nanoparticles exhibit good photostability and biocompatibility, and they can be used as multifunctional probes for MRI, thermal imaging, and photothermal ablation of cancer cells.
authors.affiliation: Advanced Membranes and Porous Materials Center, Physical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Tian
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Ke Xin
authors.initials: KX
authors.lastname: Yao
authors.forename: Baiyang
authors.initials: B
authors.lastname: Teng
authors.forename: Jizhe
authors.initials: J
authors.lastname: Zhang
authors.forename: Shiping
authors.initials: S
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D005290:Ferric Compounds; D011108:Polymers; D011758:Pyrroles; C000499:ferric oxide; C067635:polypyrrole
keywords: MRI contrast agent; multifunctional photothermal agent; photothermal conversion; polypyrrole nanoparticles; thermal therapy