title: Determination of chlorinated phenoxy acid herbicides in tobacco by modified quechERS extraction and high-performance liquid chromatography/tandem mass spectrometry.
abstract: A new method for determination of phenoxy acid herbicide residues in tobacco based on the use of liquid extraction/partition and dispersive SPE followed by HPLC/electrospray ionization-MS/MS is reported. Formic acid (2%, v/v) in acetonitrile as the extraction solvent and inclusion of citrate buffer helped partitioning of all analytes into the acetonitrile phase. Quantitative analysis was done in the multiple-reaction monitoring mode using two combinations of selected precursor ion and product ion transition for each compound. The recoveries obtained for each pesticide ranged between 85 and 110% at two spike concentration levels. Good linear relationships were observed, with the correlation coefficient (r2) >0.998 for all analytes. The method is simple, efficient, and sensitive, and each of its performance characteristics meets the requirements for determination of phenoxy acid herbicide residues in tobacco.
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou, 450000, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bian
authors.forename: Xiaoshui
authors.initials: X
authors.lastname: Chen
authors.forename: San San
authors.initials: SS
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Gangling
authors.initials: G
authors.lastname: Tang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006540:Herbicides / Q000032:analysis*; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D006540:Herbicides