title: MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.
abstract: Our study demonstrates the downregulation of microRNA-183 (miR-183) in retinoblastoma (RB) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-183 in the RB cell lines Y79, SO-RB50 and WERI-RB1 suppresses cell viability, migration and invasion. Furthermore, the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) was identified as a new target of miR-183, and restoration of the expression of LRP6 rescues the effects induced by miR-183 in RB cells. These results indicate that miR-183 targets and downregulates LRP6 in the growth, migration and invasion of RB cells.
authors.affiliation: Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: Centre of Ophthalmology and Otorhinolaryngology, Fourth Affiliated Hospital, Harbin Medical University, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.
authors.forename: Zhongji
authors.initials: Z
authors.lastname: Li
authors.affiliation: Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Teng
mesh_terms: D020413:3' Untranslated Regions; D017209:Apoptosis / Q000235:genetics; D001483:Base Sequence; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015536:Down-Regulation; D006801:Humans; D060488:Low Density Lipoprotein Receptor-Related Protein-6 / Q000235:genetics* / Q000378:metabolism*; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000378:metabolism; D019572:Retinal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D012175:Retinoblastoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology
chemical_list: D020413:3' Untranslated Regions; C555475:LRP6 protein, human; D060488:Low Density Lipoprotein Receptor-Related Protein-6; C533449:MIRN183 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D012334:RNA, Neoplasm
keywords: LRP6; cell growth; cell invasion; microRNA-183; retinoblastoma