title: [Comparison of (18)F-FDG PET/CT and enhancement CT in diagnosing regional lymph node metastasis of colorectal cancer].
abstract: OBJECTIVE
  The aim of this study was to compare the diagnostic value of (18)F-FDG PET/CT with contrast CT for regional lymph node metastasis of colorectal cancer.
  
  
  METHODS
  Imaging results of 40 patients with colorectal cancer were retrospectively reviewed, and all the patients underwent both abdomen contrast CT and (18)F-FDG PET/CT imaging. Final diagnosis was made by histopathology.
  
  
  RESULTS
  20 colorectal cancer patients were verified with lymph node metastasis while the other 20 patients were absent. Finally, (18)F-FDG PET/CT produced 4 false-positive patients and 3 false-negative patients. (18)F-FDG PET/CT displayed sensitivity 85.0% (17/20), specificity 80.0% (16/20), positive predictive value 81.0% (17/21), negative predictive value 84.2% (16/19) and accuracy 82.5% (33/40) in the diagnosis of lymph node metastasis. Contrast CT produced 5 false-positive patients and 8 false-negative patients. Contrast CT had the sensitivity 60.0% (12/20), specificity 75.0% (15/20) , positive predictive value 70.6% (12/17), negative predictive value 65.2% (15/23) and accuracy 67.5% (27/40). Sensitivity and specificity of PET/CT was better than of contrast CT, but no statistically significant difference between PET/CT and contrast CT (P = 0.478, P = 0.893; P = 0.344. Fisher's exact test and McNemar test).
  
  
  CONCLUSIONS
  Sensitivity and specificity of PET/CT was better than of contrast CT, but no statistically significant difference. Clinical works also need to select the appropriate inspection methods based on the patient's situation.
authors.affiliation: Department of Nuclear Medicine.the First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Rao
authors.forename: Qin-qin
authors.initials: QQ
authors.lastname: Yi
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Zi-ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Xiang-song
authors.initials: XS
authors.lastname: Zhang
authors.forename: Xin-chong
authors.initials: XC
authors.lastname: Shi
authors.forename: Chang
authors.initials: C
authors.lastname: Yi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18