title: The effects of hyperlipidemia on implant osseointegration in the mouse femur.
abstract: A high-fat (HF) diet inducing hyperlipidemia has been associated with the pathophysiology of major diseases, such as atherosclerosis and osteoporosis. A HF diet has significant adverse effects on bone, including lower bone density, volume, and strength. Statins, drugs that lower serum cholesterol levels have beneficial effects on bone metabolism. Since the host's bone quantity, quality, and healing potential play a crucial role in osseointegration of dental implants, we hypothesized that hyperlipidemia may negatively affect implant osseointegration. In the present study, we evaluated the effects of hyperlipidemia on implant osseointegration in mice. Atherosclerosis susceptible C57BL/6J male mice were randomly placed on a control chow or a HF diet. After 12 weeks on the diet, each mouse received a titanium implant in the proximal metaphysis of the femur. The animals were humanely killed at 4 or 8 weeks after the implant surgery. Results showed that the mice fed a HF diet had significantly increased implant loss as well as decreased formation and strength of bone-to-implant interface. These results support the hypothesis that a HF diet can significantly compromise osseointegration, causing poor outcome in dental implant therapy.
authors.affiliation: 1  University of California, Los Angeles, Calif.
authors.forename: Armand
authors.initials: A
authors.lastname: Keuroghlian
authors.forename: Ana Dilza Viana
authors.initials: AD
authors.lastname: Barroso
authors.forename: Gary
authors.initials: G
authors.lastname: Kirikian
authors.forename: Olga
authors.initials: O
authors.lastname: Bezouglaia
authors.forename: Yin
authors.initials: Y
authors.lastname: Tintut
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tetradis
authors.forename: Peter
authors.initials: P
authors.lastname: Moy
authors.forename: Flavia
authors.initials: F
authors.lastname: Pirih
authors.forename: Tara
authors.initials: T
authors.lastname: Aghaloo
mesh_terms: D000818:Animals; D015921:Dental Implants; D005269:Femur; D006949:Hyperlipidemias; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016348:Osseointegration; D011897:Random Allocation; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium
keywords: dental implant; high-fat diet; hyperlipidemia; osseointegration