title: Pedopeptins, novel inhibitors of LPS: taxonomy of producing organism, fermentation, isolation, physicochemical properties and structural elucidation.
abstract: In the course of our screening for inhibitors of lipopolysaccharide (LPS) binding to cellular receptor CD14, potent inhibitory activity was detected in the cultured broth of Pedobacter sp. SANK 72003. Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical and spectral data to be new cyclic depsipeptides.
authors.affiliation: Discovery Science and Technology Department, Daiichi-Sankyo RD Novare Co., Ltd., Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirota-Takahata
authors.affiliation: Biologics Research Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Kozuma
authors.affiliation: Exploratory Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Nahoki
authors.initials: N
authors.lastname: Kuraya
authors.affiliation: Discovery Science and Technology Department, Daiichi-Sankyo RD Novare Co., Ltd., Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fukuda
authors.affiliation: Exploratory Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Oncology Research Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ando
mesh_terms: D003470:Culture Media; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000378:metabolism; D060485:Pedobacter / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis
chemical_list: D003470:Culture Media; D047630:Depsipeptides; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D010456:Peptides, Cyclic; C000588475:pedopeptin A; C000588476:pedopeptin B; C000588477:pedopeptin C