title: A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility.
abstract: OBJECTIVE
  The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility.
  
  
  METHODS
  Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes.
  
  
  RESULTS
  In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR=1.102, 95% CI=0.830-1.462, p=0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR=0.958, 95% CI=0.811-1.132, p=0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR=1.234, 95% CI=0.908-1.677, p=0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS.
  
  
  CONCLUSIONS
  Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000483:Alleles; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D019713:Receptors, CCR5 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D019713:Receptors, CCR5