title: Intracranial meningioma as initial clinical manifestation of occult lung carcinoma: case report.
abstract: Intracranial meningioma with intratumor metastasis have been occasionally reported. However, to our knowledge, there are almost no reports of malignant tumors initially discovered due to metastasis to meningioma. A 74-year-old woman presented with amnesia. Magnetic resonance imaging showed a well-defined mass arising from falcotentorial junction and homogeneous enhancement. Histopathologic findings showed that the mass was a meningothelial meningioma, with the majority of the tumor cells propagating in sheets, however, a single area in the tumor tissue showed the different histology. Immunohistologically, cytokeratin 7 (CK7), thyroid transcription factor-1 (TTF-1), and Napsin were positive, which led to lung adenocarcinoma metastasis. Furthermore, E-cadherin staining showed a 70% positive rate in lung adenocarcinoma and 30% in meningothelial meningioma. We report our experiences regarding a case of lung cancer that metastasized to intracranial meningioma and its clinical presentation and pathology.
authors.affiliation: Department of Neurosurgery, Nara Medical University.
authors.forename: Megumi
authors.initials: M
authors.lastname: Chatani
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakagawa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hironaka
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakase
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor