title: Cytochrome p450, part 1: what nurses really need to know.
abstract: Although knowledge about the impact of cytochrome p450 on individual variations in drug response has been known for decades, the transition to clinical practice has not evolved. Nurses who administer and prescribe medications have a responsibility to their patients to understand the responses to medications that are mediated by this family of enzymes. An overview of the variations seen in drug responses based on genetics is presented with discussion focusing on the current prescriptive practices and limitations in clinical drug trials.
authors.affiliation: Vanderbilt University Medical Center, School of Nursing, 461 21st Avenue South, Nashville, TN 37240, USA. Electronic address: steve.krau@vanderbilt.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Krau
mesh_terms: D002983:Clinical Competence; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D024802:Nurse's Role; D009736:Nursing Process / Q000458:organization & administration*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D057184:Practice Patterns, Nurses' / Q000458:organization & administration*; D057285:Precision Medicine / Q000451:nursing*
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System
keywords: Adverse drug events; Adverse drug reactions; Cytochrome p450; Medication variation; Pharmacodynamics; Pharmacogenetics; Pharmacokinetics