title: Correlation between antibodies to gonadotropin-releasing hormone and reproductive disorders in humans.
abstract: Antibodies (IgG) to gonadotropin-releasing hormone were measured by ELISA in blood serum of women with miscarriage and men with infertility. Spontaneous production of antibodies to gonadotropin-releasing hormone was observed during miscarriage and male infertility: the mean level of antibodies in these groups was higher than in healthy women and men (p<0.0001). ROC-analysis showed that test for IgG to gonadotropin-releasing hormone has high sensitivity, specificity, and AUC (more that 70%, 90%, and 0.8, respectively). Thus, the presence of antibodies to gonadotropin-releasing hormone was associated with impairments of human reproductive function.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia. i_menzhinskaya@oparina4.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Menzhinskaya
authors.forename: L V
authors.initials: LV
authors.lastname: Van'ko
authors.forename: P A
authors.initials: PA
authors.lastname: Kiryushchenkov
authors.forename: G V
authors.initials: GV
authors.lastname: Ter-Avanesov
authors.forename: Yu A
authors.initials: YA
authors.lastname: Gavrilov
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007247:Infertility, Female / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D007248:Infertility, Male / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D008297:Male; D012372:ROC Curve
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007987:Gonadotropin-Releasing Hormone