title: Centralized pan-Middle East Survey on the undertreatment of hypercholesterolemia: results from the CEPHEUS study in Arabian Gulf countries.
abstract: The Centralized pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS) survey evaluated the attainment of low-density lipoprotein cholesterol (LDL-C) goals among patients on lipid-lowering drugs (LLDs) according to the updated National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP-III) guideline. The survey was conducted in 6 Arabian Gulf countries. Patients aged ≥18 years on LLDs for at least ≥3 months (stable medication for ≥6 weeks) were recruited. Fasting blood samples were collected at a single visit. In this survey, 5276 (58.2% male) patients were included in the final analysis. The LDL-C goal was attained in 91.1% of low-risk, 52.7% of high-risk, and 32.0% in very-high-risk categories. Goal attainment was directly related to female gender, age<40 years, history of diabetes, and family history of cardiovascular disease. The results of this survey highlight the suboptimal management of hypercholesterolemia across Arabian Gulf countries.
authors.affiliation: King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Arafah
authors.affiliation: Sultan Qaboos University, College of Medicine & Health Sciences, Muscat, Oman.
authors.forename: Ali T
authors.initials: AT
authors.lastname: Al-Hinai
authors.affiliation: Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
authors.forename: Wael
authors.initials: W
authors.lastname: Al Mahmeed
authors.affiliation: Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Rasadi
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: Omer
authors.initials: O
authors.lastname: Al Tamimi
authors.affiliation: King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Shorook
authors.initials: S
authors.lastname: Al Herz
authors.affiliation: Ministry of Health, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Faisal
authors.initials: F
authors.lastname: Al Anazi
authors.affiliation: Security Force Hospital, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Al Nemer
authors.affiliation: King Fahad General Hospital, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Othman
authors.initials: O
authors.lastname: Metwally
authors.affiliation: King Fahad Hospital of the University, Khobar, Kingdom of Saudi Arabia.
authors.forename: Akram
authors.initials: A
authors.lastname: Alkhadra
authors.affiliation: King Fahad Hospital of the University, Khobar, Kingdom of Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Fakhry
authors.affiliation: Soliman Fakieh Hospital, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Hossam
authors.initials: H
authors.lastname: Elghetany
authors.affiliation: Dubai Hospital, Dubai, United Arab Emirates.
authors.forename: Abdel Razak
authors.initials: AR
authors.lastname: Medani
authors.affiliation: Dubai Hospital, Dubai, United Arab Emirates.
authors.forename: Afzal Hussein
authors.initials: AH
authors.lastname: Yusufali
authors.affiliation: Dubai Hospital, Dubai, United Arab Emirates.
authors.forename: Obaid
authors.initials: O
authors.lastname: Al Jassim
authors.affiliation: American Hospital, Dubai, United Arab Emirates.
authors.forename: Omar
authors.initials: O
authors.lastname: Al Hallaq
authors.affiliation: Rashid Hospital, Dubai, United Arab Emirates.
authors.forename: Fahad Omar Ahmed S
authors.initials: FO
authors.lastname: Baslaib
authors.affiliation: Al Amiri Hospital, Kuwait City, Kuwait.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Alawadhi
authors.affiliation: Bahrain Defence Force Hospital, Riffa, Bahrain.
authors.forename: Haitham
authors.initials: H
authors.lastname: Amin
authors.affiliation: Sultan Qaboos University, College of Medicine & Health Sciences, Muscat, Oman.
authors.forename: Khamis
authors.initials: K
authors.lastname: Al-Hashmi
authors.affiliation: UAE University, AlAin, United Arab Emirates a.shehab@uaeu.ac.ae.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Shehab
mesh_terms: D000328:Adult; D000368:Aged; D018912:Arabs; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D006306:Health Surveys; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D008877:Middle East; D011785:Quality Assurance, Health Care; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D008055:Lipids
keywords: Arabian Gulf countries; cardiovascular; coronary; guidelines; hypercholesterolemia; lipids; low-density lipoprotein