title: Primary prevention of diabetic retinopathy with fibrates: a retrospective, matched cohort study.
abstract: OBJECTIVE
  To compare the progression of diabetic retinopathy (DR) in people with type 2 diabetes treated with fibrates with that of non-exposed controls.
  
  
  METHODS
  Retrospective, matched cohort study.
  
  
  METHODS
  UK Clinical Practice Research Datalink (CPRD).
  
  
  METHODS
  5038 people with type 2 diabetes with a history of fibrate exposure but without evidence of DR were identified. Three thousand one hundred and seventy-six (63%) people could be randomly matched to one non-exposed control; of these, 2599 (81.8%) were matched without any missing blood pressure or glycated haemoglobin (HbA1c) values.
  
  
  METHODS
  The primary endpoint was first recorded DR with a secondary endpoint of all-cause mortality or first DR. Time to clinical endpoints was compared using Cox proportional hazards models.
  
  
  RESULTS
  Mean follow-up was 5.1 and 5.0 years for fibrate-exposed and non-exposed patients, respectively. For fibrate-exposed participants, there was a reduction in DR: 33.4 events/1000 person-years vs 40.4 (p=0.002), and in death or DR: 50.6 vs 60.2 (p<0.001). For those matched with full systolic blood pressure and HbA1c data, crude event rates were 34.3 versus 43.9 for DR (p<0.001) and 51.2 vs 63.4 (p<0.001) for death or DR. Following adjustment, DR was significantly delayed for those treated with fibrates, with an adjusted HR (aHR) of 0.785 (p<0.001) for participants with complete data and an aHR of 0.802 (p<0.001) for all participants.
  
  
  CONCLUSIONS
  The treatment with fibrates in people with type 2 diabetes was independently associated with reduced progression to a first diagnosis of DR.
authors.affiliation: Department of Primary Care and Public Health, School of Medicine, Cardiff University, The Pharma Research Centre, Cardiff Medicentre, Cardiff, UK.
authors.forename: Christopher Ll
authors.initials: CL
authors.lastname: Morgan
authors.forename: David R
authors.initials: DR
authors.lastname: Owens
authors.forename: Patrick
authors.initials: P
authors.lastname: Aubonnet
authors.forename: Emma S M
authors.initials: ES
authors.lastname: Carr
authors.forename: Sara
authors.initials: S
authors.lastname: Jenkins-Jones
authors.forename: Chris D
authors.initials: CD
authors.lastname: Poole
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Currie
keywords: Diabetes & Endocrinology; Fibrate