title: Regenerative nanomedicine for vision restoration.
abstract: Herein, we discuss recent applications of nanotechnology to ophthalmology, including nanoparticles for drug, gene, and trophic factor delivery; regenerative medicine (in the areas of optogenetics and optic nerve regeneration); and diagnostics (eg, minimally invasive biometric monitoring). Specific applications for the management of choroidal neovascularization, retinal neovascularization, oxidative damage, optic nerve damage, and retinal degenerative disease are considered. Nanotechnology will play an important role in early- and late-stage interventions in the management of blinding diseases.
authors.affiliation: Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University, Newark, NJ. Electronic address: zarbin@rutgers.edu.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Zarbin
authors.forename: Timothy
authors.initials: T
authors.lastname: Arlow
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
mesh_terms: D001766:Blindness / Q000209:etiology / Q000517:prevention & control*; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000628:therapy; D005128:Eye Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D050997:Nanomedicine; D036103:Nanotechnology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000628:therapy; D044968:Regenerative Medicine; D012162:Retinal Degeneration / Q000175:diagnosis / Q000628:therapy; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000628:therapy; D014786:Vision Disorders / Q000175:diagnosis / Q000628:therapy; D014785:Vision, Ocular
keywords: AAQ; CNV; ChR2; ECM; GDNF; HaloR; IOP; PCL; PEDF; PEG; RGC; RPE; VEGF; acrylamide-azobenzene-quaternary ammonium; channelrhodopsin-2; choroidal new vessel; extracellular matrix; glial cell line–derived neurotrophic factor; halorhodopsin; intraocular pressure; pigment epithelium–derived factor; poly(ε-caprolactone); polyethylene glycol; retinal ganglion cell; retinal pigment epithelium; shRNA; short hairpin RNA; siRNA; small interfering RNA; vascular endothelial growth factor