title: One-pot synthesis of biocompatible superparamagnetic iron oxide nanoparticles/hydrogel based on salep: characterization and drug delivery.
abstract: This work describes synthesis of biocompatible magnetic iron oxide nanoparticles/hydrogel based on salep (MION-salep hydrogel) by a facile one-pot strategy. The prepared sample was characterized by techniques like scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDAX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). The obtained MION had an 8 nm diameter with a narrow size distribution and was superparamagnetic with large saturation magnetization at room temperature. The most attractive feature of the obtained sample was its swelling properties under external magnetic field (EMF), different temperatures, and pHs. Moreover, MION-salep hydrogel showed ability to deferasirox release at pH=7 with non-Fickian diffusion mechanism. An in vitro cytotoxicity study implied that the as-synthesized sample is nontoxic.
authors.affiliation: Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran. Electronic address: grezanejad@ymail.com.
authors.forename: Ghasem Rezanejade
authors.initials: GR
authors.lastname: Bardajee
authors.forename: Zari
authors.initials: Z
authors.lastname: Hooshyar
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D059346:Magnets / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D029595:Orchidaceae / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Drug delivery; Hydrogel; Magnetic iron oxide nanoparticles; Salep