title: A versatile RNA vector for delivery of coding and noncoding RNAs.
abstract: The discovery that RNA viruses, lacking any DNA intermediate, can be engineered to express both coding and noncoding RNAs suggests that this platform may have therapeutic value as a delivery vehicle. Here we illustrate that a self-replicating, noninfectious RNA, modeled on influenza virus, provides one such example of a versatile in vivo delivery system for silencing and/or expressing a desired RNA for therapeutic purposes.
authors.affiliation: Dept. of Microbiology at the Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Sonja
authors.initials: S
authors.lastname: Schmid
authors.forename: Lum C
authors.initials: LC
authors.lastname: Zony
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: tenOever
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D004285:Dogs; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D061985:Madin Darby Canine Kidney Cells; D034622:RNA Interference; D012328:RNA Viruses / Q000235:genetics*; D014161:Transduction, Genetic / Q000379:methods*