title: Speciation mediated by centromeres.
abstract: Speciation accompanies reproductive isolation in natural populations through hybrid sterility or lethality. However, the molecular bases of hybrid lethality are mysterious. In this issue of Developmental Cell, Thomae et al. (2013) demonstrate that Drosophila speciation factors HMR and LHR form a centromeric complex and that increased dosage causes hybrid lethality.
authors.affiliation: Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan. Electronic address: tfukagaw@lab.nig.ac.jp.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Fukagawa
mesh_terms: D000818:Animals; D002503:Centromere / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000378:metabolism*; D005298:Fertility / Q000235:genetics*; D005804:Genes, Lethal; D008297:Male; D060047:Reproductive Isolation
chemical_list: D029721:Drosophila Proteins; C495958:Hmr protein, Drosophila; C515258:Lhr protein, Drosophila