title: The role of bacterial protein tyrosine phosphatases in the regulation of the biosynthesis of secreted polysaccharides.
abstract: CONCLUSIONS
  Tyrosine phosphorylation and associated protein tyrosine phosphatases are gaining prominence as critical mechanisms in the regulation of fundamental processes in a wide variety of bacteria. In particular, these phosphatases have been associated with the control of the biosynthesis of capsular polysaccharides and extracellular polysaccharides, critically important virulence factors for bacteria.
  
  
  BACKGROUND
  Deletion and overexpression of the phosphatases result in altered polysaccharide biosynthesis in a range of bacteria. The recent structures of associated auto-phosphorylating tyrosine kinases have suggested that the phosphatases may be critical for the cycling of the kinases between monomers and higher order oligomers.
  
  
  RESULTS
  Additional substrates of the phosphatases apart from cognate kinases are currently being identified. These are likely to be critical to our understanding of the mechanism by which polysaccharide biosynthesis is regulated.
  
  
  CONCLUSIONS
  Ultimately, these protein tyrosine phosphatases are an attractive target for the development of novel antimicrobials. This is particularly the case for the polymerase and histidinol phosphatase family, which is predominantly found in bacteria. Furthermore, the determination of bacterial tyrosine phosphoproteomes will likely help to uncover the fundamental roles, mechanism, and critical importance of these phosphatases in a wide range of bacteria.
authors.affiliation: School of Molecular and Biomedical Science, University of Adelaide , Adelaide, Australia .
authors.forename: Alistair J
authors.initials: AJ
authors.lastname: Standish
authors.forename: Renato
authors.initials: R
authors.lastname: Morona
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D008958:Models, Molecular; D011134:Polysaccharides / Q000096:biosynthesis* / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*
chemical_list: D011134:Polysaccharides; D017027:Protein Tyrosine Phosphatases