title: The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application.
abstract: A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH2 on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH2 in HaCaT cells and B16F10 cells. SFKLRY-NH2 induced no skin irritation at low concentration (10 μM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH2 in clinical use.
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-755 Korea.
authors.forename: Dong Ha
authors.initials: DH
authors.lastname: Kim
authors.forename: Yun Young
authors.initials: YY
authors.lastname: Lim
authors.forename: Hyeong Mi
authors.initials: HM
authors.lastname: Kim
authors.forename: So Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Sung-Gil
authors.initials: SG
authors.lastname: Park
authors.forename: Taehoon
authors.initials: T
authors.lastname: Lee
authors.forename: Soo-Muk
authors.initials: SM
authors.lastname: Cho
keywords: PS-SPCL; SFKLRY-NH2; Safety; Skin irritation test; W3 peptide