title: Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a randomized placebo-controlled trial.
abstract: Although antiretroviral therapy has revolutionized the care of HIV-infected patients, it has been associated with metabolic abnormalities. Hence, this study was planned to investigate the effects of fish oil on lipid profile, insulin resistance, and body fat distribution in HIV-infected Brazilian patients on antiretroviral therapy, considering that marine omega-3 fatty acids seem to improve features of the metabolic syndrome. We conducted a randomized, parallel, placebo-controlled trial that assessed the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid plus 360 mg of docosahexaenoic acid) or 3 g soy oil/day (placebo) on 83 HIV-infected Brazilian men and non-pregnant women on antiretroviral therapy. No statistically significant relationships between fish oil supplementation and longitudinal changes in triglyceride (p = 0.335), low-density lipoprotein cholesterol (p = 0.078), high-density lipoprotein cholesterol (p = 0.383), total cholesterol (p = 0.072), apolipoprotein B (p = 0.522), apolipoprotein A1 (p = 0.420), low-density lipoprotein cholesterol/apolipoprotein B ratio (p = 0.107), homeostasis model assessment for insulin resistance index (p = 0.387), body mass index (p = 0.068), waist circumference (p = 0.128), and waist/hip ratio (p = 0.359) were observed. A low dose of fish oil did not alter lipid profile, insulin resistance, and body fat distribution in HIV-infected patients on antiretroviral therapy.
authors.affiliation: School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
authors.forename: Julicristie M
authors.initials: JM
authors.lastname: Oliveira
authors.forename: Patrícia H C
authors.initials: PH
authors.lastname: Rondó
authors.forename: John S
authors.initials: JS
authors.lastname: Yudkin
authors.forename: José M P
authors.initials: JM
authors.lastname: Souza
authors.forename: Tatiane N
authors.initials: TN
authors.lastname: Pereira
authors.forename: Andrea W
authors.initials: AW
authors.lastname: Catalani
authors.forename: Camila M
authors.initials: CM
authors.lastname: Picone
authors.forename: Aluisio A C
authors.initials: AA
authors.lastname: Segurado
mesh_terms: D000328:Adult; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D050218:Body Fat Distribution; D015992:Body Mass Index; D001938:Brazil; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D013024:Soybean Oil; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D005395:Fish Oils; D007328:Insulin; D008055:Lipids; D013024:Soybean Oil
keywords: AIDS; HIV; fish oils; hypertriglyceridaemia; insulin resistance; lipid profile; lipodystrophy; low-density lipoprotein cholesterol; metabolic syndrome; omega-3 fatty acids