title: Novel putative mechanisms to link circadian clocks to healthy aging.
abstract: The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Rostock Medical School, Rostock, Germany, aurel.popa-wagner@med.uni-rostock.de.
authors.forename: Aurel
authors.initials: A
authors.lastname: Popa-Wagner
authors.forename: Bogdan
authors.initials: B
authors.lastname: Catalin
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Buga
mesh_terms: D000375:Aging / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics / Q000503:physiopathology
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins