title: Release kinetics of N-terminal pro-B-type natriuretic peptide in a clinical model of acute myocardial infarction.
abstract: BACKGROUND
  N-terminal segment of B-type natriuretic peptide prohormone (NT-proBNP) is elevated in patients with acute myocardial infarction (AMI) thus providing both diagnostic information and prognostic information. The aim of the present study was to determine the time course of NT-proBNP release in patients undergoing transcoronary ablation of septal hypertrophy (TASH) a procedure mimicking AMI.
  
  
  METHODS
  We analyzed the release kinetics of NT-proBNP in 18 consecutive patients with hypertrophic obstructive cardiomyopathy undergoing TASH. Serum samples were collected prior to and at 15, 30, 45, 60, 75, 90, and 105 min, and 2, 4, 8, and 24h after TASH.
  
  
  RESULTS
  NT-proBNP concentrations showed a continuous increase during the first 75 min with a significant percent change compared to baseline value already 15 min after TASH (105.6% [IQR 102.2-112.7]; P<0.001). All patients had a significant increase of NT-proBNP at 45 min (range of percent increase [min-max]: 103.5-137.2%; range of absolute increase [min-max]: 23.5-304.0 ng/L). NT-proBNP concentrations decreased below the baseline value until the 8th h after initiation of myocardial infarction.
  
  
  CONCLUSIONS
  NT-proBNP concentration increases immediately after induction of myocardial infarction proving early evidence of myocardial injury despite the decrease of the left ventricular wall stress due to the TASH related reduction of the left ventricular outflow gradient.
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany; Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany. Electronic address: c.liebetrau@kerckhoff-klinik.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Liebetrau
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Luise
authors.initials: L
authors.lastname: Gaede
authors.affiliation: Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Dörr
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Troidl
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Voss
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Hoffmann
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Agata
authors.initials: A
authors.lastname: Paszko
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rolf
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany; Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hamm
authors.affiliation: Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Nef
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
mesh_terms: D055011:Ablation Techniques; D000208:Acute Disease; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D005260:Female; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000150:complications / Q000628:therapy; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000378:metabolism* / Q000628:therapy; D011498:Protein Precursors / Q000378:metabolism*
chemical_list: C099254:N-terminal proatrial natriuretic peptide; D011498:Protein Precursors; D009320:Atrial Natriuretic Factor
keywords: N-terminal pro-B-type natriuretic peptide; Release kinetics; Transcoronary ablation of septal hypertrophy