title: Synthesis of [15, 16- ³H] beta-funaltrexamine.
abstract: Beta-funaltrexamine is a unique irreversible antagonist for the mu-opiate receptor and would be useful as a tritiated radioligand. Starting from high specific activity [15, 16-³H] naltrexone, [15, 16-³H] beta-funaltrexamine was synthesized and characterized by means of a two-step reductive amination-acylation process.
authors.affiliation: PerkinElmer Life Sciences & Technology Inc., 940 Winter Street, Waltham, MA, 02451, USA.
authors.forename: Crist N
authors.initials: CN
authors.lastname: Filer
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Seguin
mesh_terms: D007553:Isotope Labeling / Q000379:methods*; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014316:Tritium / Q000737:chemistry
chemical_list: D019275:Radiopharmaceuticals; D014316:Tritium; D009271:Naltrexone; C024524:beta-funaltrexamine
keywords: beta-funaltrexamine; irreversible; opiate receptor; tritium