title: Osteolineage cells and regulation of the hematopoietic stem cell.
abstract: Over the last 10 years, progress has been made in understanding the relationship between hematopoietic stem cells and their microenvironment, or niche. Increased knowledge of the microenvironment and its effects on hematopoiesis and leukemogenesis based on murine models may lead to the identification of relevant new therapeutic targets for leukemia. In particular, the chemokine CCL3 has potential as a mediator of leukemia-induced microenvironmental changes, as it has been found to be increased in human acute myeloid leukemia.
authors.affiliation: University of Rochester School of Medicine, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA. Electronic address: Laura_Calvi_@urmc.rochester.edu.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Calvi
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation; D054405:Chemokine CCL3 / Q000235:genetics* / Q000276:immunology; D004195:Disease Models, Animal; D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000473:pathology; D051379:Mice; D010006:Osteoblasts / Q000276:immunology* / Q000473:pathology; D055153:Stem Cell Niche / Q000235:genetics / Q000276:immunology
chemical_list: C515429:CCL3 protein, human; D054405:Chemokine CCL3
keywords: CCL3; acute leukemia; hematopoietic stem cell; microenvironment; niche; targets