title: Planar cell polarity and the kidney.
abstract: Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure, heart development and lung branching. In this review, we outline the evidence implicating PCP in kidney development and disease focusing initially on the function of PCP in ureteric bud branching and elongation. We then describe how defects in PCP may lead to polycystic kidney disease and discuss a newly identified role for PCP in the kidney filtration barrier.
authors.affiliation: Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Papakrivopoulou
authors.affiliation: Leukocyte Biology, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Charlotte H
authors.initials: CH
authors.lastname: Dean
authors.affiliation: Neural Development Unit, UCL Institute of Child Health, London WC1N 1EH, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Copp
authors.affiliation: Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Long
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007690:Polycystic Kidney Diseases / Q000503:physiopathology*
keywords: cell alignment; glomerular filtration barrier; kidney development; polycystic kidney disease; ureteric bud branching