title: Determining optimal noninvasive parameters for the prediction of left ventricular remodeling in chronic ischemic patients.
abstract: OBJECTIVE
  DOPPLER-CIP aims to determine the optimal noninvasive parameters (myocardial function, perfusion, ventricular blood flow, cell integrity) and methodology (ergometry, echocardiography, scintigraphy, MRI) in a given ischemic substrate that best predicts the impact of an intervention (or the lack thereof) on adverse morphological ventricular remodeling and functional recovery. Moreover, the relative predictive value of each of these parameters, in respect to the cost of extracting this information in order to enable optimization of cost-effectiveness for improved health care, will be determined by this project.
  
  
  METHODS
  DOPPLER-CIP is a multi-center registry study. All patients with ischemic heart disease included in this study undergo at least two noninvasive stress imaging examinations at baseline. The presence/or absence of left ventricular (LV) remodeling will be assessed after a follow-up of 2 years, during which all cardiac events will be registered.
  
  
  RESULTS
  676 patients were included. Currently, baseline data analysis is almost finished and the follow-up is ongoing.
  
  
  CONCLUSIONS
  After completion, DOPPLER-CIP will provide evidence-based guidelines toward the most effective use of cardiac imaging in the chronically ischemic heart disease patient. The study will generate information, knowledge, and insight into the new imaging methodologies and into the pathophysiology of chronic ischemic heart disease.
authors.affiliation: University Hospitals Leuven and KU Leuven, Department of Cardiovascular Sciences , Leuven , Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Rademakers
authors.forename: Jan
authors.initials: J
authors.lastname: Engvall
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.forename: Mark
authors.initials: M
authors.lastname: Monaghan
authors.forename: Rosa
authors.initials: R
authors.lastname: Sicari
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
authors.forename: José
authors.initials: J
authors.lastname: Zamorano
authors.forename: Heikki
authors.initials: H
authors.lastname: Ukkonen
authors.forename: Tino
authors.initials: T
authors.lastname: Ebbers
authors.forename: Vitantonio
authors.initials: V
authors.lastname: Di Bello
authors.forename: Jens-Uwe
authors.initials: JU
authors.lastname: Voigt
authors.forename: Lieven
authors.initials: L
authors.lastname: Herbots
authors.forename: Piet
authors.initials: P
authors.lastname: Claus
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
mesh_terms: D002908:Chronic Disease; D003952:Diagnostic Imaging / Q000379:methods; D015150:Echocardiography, Doppler; D025401:Echocardiography, Stress; D019560:Echocardiography, Three-Dimensional; D004562:Electrocardiography; D005060:Europe; D005080:Exercise Test; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D055420:Perfusion Imaging; D011237:Predictive Value of Tests; D011379:Prognosis; D012042:Registries; D011795:Surveys and Questionnaires; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling