title: Angiogenesis and melanoma.
abstract: Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host's blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.
authors.affiliation: Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy. ribatti@anatomia.uniba.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Annese
authors.forename: Vito
authors.initials: V
authors.lastname: Longo