title: First trimester maternal characteristics, Doppler parameters and serum analytes after preeclampsia.
abstract: OBJECTIVE
  To evaluate the impact of prior preeclampsia on first trimester assessment in subsequent pregnancy.
  
  
  METHODS
  A total of 1283 parous patients were prospectively enrolled at 9-14 weeks of gestation. Maternal biophysical characteristics, ultrasound parameters and placental analytes were compared between women with and without prior preeclampsia.
  
  
  RESULTS
  There is no association between prior preeclampsia and the first trimester ultrasound parameters or placental analytes studied. The effects of prior preeclampsia in subsequent pregnancy are exaggerated by increasing parity and are predominantly blood pressure-related, independent of other cardiovascular risk factors.
  
  
  CONCLUSIONS
  There is a potential role for lifestyle modification and stricter pregnancy blood pressure control in patients with prior preeclampsia.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine , Baltimore, MD , USA .
authors.forename: Dana M
authors.initials: DM
authors.lastname: Block-Abraham
authors.forename: Ozhan M
authors.initials: OM
authors.lastname: Turan
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Doyle
authors.forename: Jerome N
authors.initials: JN
authors.lastname: Kopelman
authors.forename: Robert O
authors.initials: RO
authors.lastname: Atlas
authors.forename: Chuka B
authors.initials: CB
authors.lastname: Jenkins
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Harman
authors.forename: Miriam G
authors.initials: MG
authors.lastname: Blitzer
authors.forename: Ahmet A
authors.initials: AA
authors.lastname: Baschat
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000502:physiology*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011446:Prospective Studies; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human