title: De novo design of functional proteins: Toward artificial hydrogenases.
abstract: Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.
authors.affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ.
authors.forename: Marina
authors.initials: M
authors.lastname: Faiella
authors.forename: Anindya
authors.initials: A
authors.lastname: Roy
authors.forename: Dayn
authors.initials: D
authors.lastname: Sommer
authors.forename: Giovanna
authors.initials: G
authors.lastname: Ghirlanda
mesh_terms: D002384:Catalysis; D006864:Hydrogenase; D007501:Iron; D010455:Peptides
chemical_list: D010455:Peptides; D007501:Iron; D006864:Hydrogenase
keywords: catalysis; de novo design; hydrogenase; iron-sulfur clusters; peptide