title: A bicyclic diterpenoid with a new 15,16-dinorlabdane carbon skeleton from Leonurus japonicus and its coagulant bioactivity.
abstract: A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3-5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, China. xiling0505@126.com.
authors.forename: Fu
authors.initials: F
authors.lastname: Peng
authors.forename: Liang
authors.initials: L
authors.lastname: Xiong
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D000818:Animals; D003029:Coagulants / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D031332:Leonurus / Q000737:chemistry*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D017207:Rats, Sprague-Dawley; D013918:Thrombin Time
chemical_list: D003029:Coagulants; D004224:Diterpenes; D005340:Fibrinogen