title: [Efficacies of bone-marrow-derived mononuclear cells with a hydroxylapatite composite in the treatment of osteonecrosis of the femoral head].
abstract: OBJECTIVE
  To evaluate the efficacies of core decompression and implantation of concentrated autologous bone marrow containing mononuclear cells (BMMCs) with porous hydroxylapatite composite in the treatment of osteonecrosis of the femoral head.
  
  
  METHODS
  A total of 35 patients with 57 osteonecrosis hips with ARCO stage I, stage II and stage IIIA disease were treated by BMMCs with a porous hydroxylapatite composite. The mean age at surgery was 39.4 (26-58) years and the mean period of follow-up 28 (12-40) months. In the control group, cell-free porous hydroxylapatite composite was implanted into 17 patients (27 hips) with osteonecrosis of the femoral head and the outcomes were compared.
  
  
  RESULTS
  At the last follow-up, postoperative Harris hip scores significantly increased in both groups (P < 0.0001). The magnitude of increase was significantly greater in the BMMCs group compared with the control group (28.3% ± 0.9% vs 18.4% ± 1.7%, P < 0.01). Postoperative visual analog scale (VAS) scores significantly decreased in both groups (P < 0.01). The magnitude of decrease was significantly greater in the BMMCs group compared with the control group (-70.2% ± 2.1% vs -51.7% ± 2.9%, P < 0.001). The clinical success rate was significantly higher in the BMMCs group compared with the control group (75.4% vs 37.0%, P < 0.01). The radiological success rates were similar between the BMMCs and control groups (59.6% vs 40.7%, P = 0.1046).
  
  
  CONCLUSIONS
  The combined regimen of core decompression and implantation of concentrated autologous BMMCs with porous hydroxylapatite composite appears to confer benefits in the treatment of in stages I-IIIA osteonecrosis of the femoral head.
authors.affiliation: Department of Orthopedic Surgery, PLA No. 307 Hospital, Beijing 100071, China.
authors.forename: Yao-sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Liu
authors.forename: Shi-guo
authors.initials: SG
authors.lastname: Zhou
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Su
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Wei-hao
authors.initials: WH
authors.lastname: Jiang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Jing-dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D016026:Bone Marrow Transplantation; D019299:Decompression, Surgical; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D017886:Durapatite