title: [Coagulation and prothrombotic state parameters: clinical analysis in early pregnancy].
abstract: OBJECTIVE
  To assess the changes in coagulation, thrombosis, anti-coagulation and fibrinolysis during early pregnancy.
  
  
  METHODS
  A total of 105 gravidas with monocytic pregnancies between 10 and 12 weeks gestational age at Sun Yat-sen Memorial Hospital, Sun Yat-sen University during April 2005 to June 2009 were recruited for study group and another 82 non-pregnant women as control group. Coagulation parameters, including thrombin time (TT), activated partial thromboplastin time (APTT), prothrombin (PT) and fibrinogen (Fg), were measured. We also tested the prothrombotic state parameters, including prothrombin fragment 1+2 (F1+2), thrombomodulin (TM), thrombin-antithrombin complex (TAT), antithrombin III(AT-III), GMP140, thromboxane B2 (TXB2), plasminogen activator inhibitor (PAI-2; performed by enzyme-linked immunosorbent assay) and D-dimer (D2; tested by latex turbidimetric immunoassay).
  
  
  RESULTS
  Fg (4.00 vs 2.52 g/L), F1+2 (0.66 vs 0.31 nmol/L), TAT (179.95 vs 39.46 µg/L), GMP140 (9.42 vs 19.13 µg/L), D2 (201.51 vs 125.02 µg/L) and PAI-2 (0.047 vs 0.006 g/L) were statistically different between the study and control groups (P < 0.01).
  
  
  CONCLUSIONS
  The coagulation, fibrinolysis and anti-fibrinolysis functions of healthy pregnant women become enhanced during early pregnancy while anti-coagulation function slightly increases. These four basic functions are balanced at a higher level so that the activation of platelets stays at a lower level.
authors.affiliation: Department of Gynecology & Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Li-bin
authors.initials: LB
authors.lastname: Chen
authors.forename: Li-li
authors.initials: LL
authors.lastname: Meng
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Bi-jun
authors.initials: BJ
authors.lastname: Du
authors.forename: Li-qiong
authors.initials: LQ
authors.lastname: Zhu
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Tan
mesh_terms: D000990:Antithrombin III / Q000032:analysis*; D001777:Blood Coagulation / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D010447:Peptide Hydrolases / Q000032:analysis*; D015539:Platelet Activation; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013929:Thromboxane B2 / Q000097:blood*
chemical_list: C046193:antithrombin III-protease complex; D013929:Thromboxane B2; D000990:Antithrombin III; D010447:Peptide Hydrolases