title: Facile preparation of dehydrodigallic acid and its derivative for the synthesis of ellagitannins.
abstract: A facile method for the synthesis of dehydrodigallic acid, which is a fundamental structure of ellagitannins, was developed. A classical Ullmann condition was effective for the formation of the highly hindered biaryl ether structure, and we clarified that the suitable protection of the phenolic hydroxy groups was crucial in this reaction. In this way, the synthesis of dehydrodigallic acid and its derivative was successfully performed. The described method would provide a synthetic utility toward ellagitannins.
authors.affiliation: Graduate School of Science and Engineering, University of Toyama.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Shioe
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishikura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Horino
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Abe
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D053630:Depsides / Q000138:chemical synthesis* / Q000737:chemistry; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D047348:Hydrolyzable Tannins / Q000138:chemical synthesis* / Q000737:chemistry; D010944:Plants / Q000737:chemistry*
chemical_list: D001688:Biological Products; D053630:Depsides; D047348:Hydrolyzable Tannins; C013515:ellagitannin; C067648:digallic acid; D005707:Gallic Acid