title: Successful treatment with fumagillin of the first pediatric case of digestive microsporidiosis in a liver-kidney transplant.
abstract: We report the first successful use, to our knowledge, of fumagillin alone in a pediatric patient to cure intestinal microsporidiosis in a liver-kidney transplanted child. Detection of Enterocytozoon bieneusi in stool became negative from the first post-therapeutic control, while digestive symptoms disappeared in 4 days. During a 9-month follow-up, polymerase chain reaction and direct examinations remained negative for microsporidia in her feces. No major undesirable effects were noted during the anti-microsporidial therapy.
authors.affiliation: Service de Parasitologie - Mycologie - Médecine tropicale, CHU de Tours, Tours, France; Faculté de Médecine, Université François Rabelais, CEPR UMR INSERM U1100/E.A. 6305, Tours, France.
authors.forename: G
authors.initials: G
authors.lastname: Desoubeaux
authors.forename: Z
authors.initials: Z
authors.lastname: Maakaroun-Vermesse
authors.forename: C
authors.initials: C
authors.lastname: Lier
authors.forename: E
authors.initials: E
authors.lastname: Bailly
authors.forename: F
authors.initials: F
authors.lastname: Morio
authors.forename: F
authors.initials: F
authors.lastname: Labarthe
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Chandenier
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003510:Cyclohexanes / Q000627:therapeutic use*; D003967:Diarrhea / Q000382:microbiology; D021862:Enterocytozoon / Q000235:genetics / Q000302:isolation & purification*; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D016881:Microsporidiosis / Q000188:drug therapy* / Q000382:microbiology; D012717:Sesquiterpenes / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; C026211:fumagillin
keywords: Enterocytozoon bieneusi; PCR; fumagillin; intestinal microsporidiosis; liver-kidney transplant; pediatrics