title: Sodium copper chlorophyllin (SCC) induces genetic damage in postmeiotic and somatic wing cells of Drosophila melanogaster.
abstract: There is no apparent evidence to indicate that sodium copper chlorophyllin (SCC) is mutagenic. The aim of the present study was thus to determine the mutagenic effect of SCC, in postmeiotic germ cells of the adult male Drosophila. This investigation was based on the ability to examine whether SCC induced sex-linked recessive lethal mutations (SLRL), as well as the somatic mutation and recombination test (SMART). Four different SCC concentrations were used: 0, 45, 69, 80, and 100 mM. For SLRL, two broods were generated to test sperm and primarily spermatids. Results showed a significant frequency of recessive lethal mutations compared with control sperm cells with SCC at 69, 80, and 100 mM. In contrast, the frequency of somatic mutations rose by 0.21 only with 100 mM of SCC. These findings provide evidence that SCC is a weak mutagen in both cell lines. The differential response may be attributed to repair mechanisms that are active in somatic cells but almost absent in germ cells.
authors.affiliation: a Departamento de Biología , Instituto Nacional de Investigaciones Nucleares (ININ), La Marquesa , Ocoyoacac , México.
authors.forename: Emilio Pimentel
authors.initials: EP
authors.lastname: Peñaloza
authors.forename: Martha Patricia
authors.initials: MP
authors.lastname: Cruces Martínez
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000633:toxicity*; D002735:Chlorophyllides / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects* / Q000235:genetics*; D008297:Male; D009152:Mutagenicity Tests; D013094:Spermatozoa / Q000187:drug effects; D014921:Wings, Animal / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D002735:Chlorophyllides; C007020:chlorophyllin