title: Mechanisms underlying effects of 1,25-Dihydroxyvitamin D3 on the Th17 cells.
abstract: Th17 cells, a class of CD4(+) T cells, have been identified as novel effector cells, which play a pivotal role in several inflammatory and autoimmune diseases. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has emerged as a direct regulator of immune system function in humans. Accumulating reports demonstrated that 1,25(OH)2D3 possessed anti-inflammatory activity on Th17 cells to maintain immunologic homeostasis. This report will review the novel immune regulatory role of 1,25(OH)2D3 in its potential use for Th17 cell-related inflammatory and autoimmune conditions.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: David Q
authors.initials: DQ
authors.lastname: Shih
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zhang
keywords: 1,25(OH)2D3; Th17; VDR; immune response