title: Biomimetic strategies incorporating enzymes into CaP coatings mimicking the in vivo environment.
abstract: Biomimetic calcium phosphate coating (CaP) methodology mimics the natural biomineralization process of bone, which involves two phases: nucleation and growth. In this chapter we present a successful method to coating biodegradable natural-origin materials with biomimetic CaP layer as a strategy to incorporate enzymes with the main aim of controlling and tailoring their degradation over time. This strategy seems to enhance the bone-bonding, osteoconductive, and osteoinductive properties of natural-origin biomaterials that per se do not present these characteristics.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Caldas das Taipas, Guimarães, 4806-909, Portugal, ana@dep.uminho.pt.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Martins
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
mesh_terms: D032701:Biomimetics / Q000379:methods*; D002130:Calcium Phosphates / Q000494:pharmacology*; D048271:Chitosan / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009113:Muramidase / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D048271:Chitosan; C020243:calcium phosphate; D009113:Muramidase