title: Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.
abstract: Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University.
authors.forename: Shinya
authors.initials: S
authors.lastname: Iida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kamiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakaya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sawada
authors.forename: Noritada
authors.initials: N
authors.lastname: Kaji
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Baba
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Harashima
mesh_terms: D000818:Animals; D001217:Aspartate-Ammonia Ligase / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis*; D055785:Gene Knockdown Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D001786:Blood Glucose; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D001217:Aspartate-Ammonia Ligase