title: Replicating damaged DNA in eukaryotes.
abstract: DNA damage is one of many possible perturbations that challenge the mechanisms that preserve genetic stability during the copying of the eukaryotic genome in S phase. This short review provides, in the first part, a general introduction to the topic and an overview of checkpoint responses. In the second part, the mechanisms of error-free tolerance in response to fork-arresting DNA damage will be discussed in some detail.
authors.affiliation: Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: Nimrat
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Wolfram
authors.initials: W
authors.lastname: Siede
mesh_terms: D002453:Cell Cycle / Q000502:physiology; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D056890:Eukaryota / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008958:Models, Molecular