title: ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi population.
abstract: Type 2 diabetes mellitus (T2DM) is a disease induced by complex interactions between environmental factors and certain genetic factors. Genetic variants in the Adenosine Binding Cassette Transporter Proteins 1 (ABCA1) have been associated with abnormalities of serum lipid levels of high-density lipoprotein (HDL-C). Decreased serum levels of HDL-C have often been observed in T2DM cases, and this condition has been considered to be involved in the mechanism of insulin resistance (IR). Therefore, we investigated possible association between ABCA1 C69T gene polymorphism and T2DMin a Saudi population. This study was carried out with 380 healthy control subjects and 376 T2DM patients. Genotyping of ABCA1 C69T polymorphism was carried out by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique. We observed that the frequency of the T allele of the ABCA1 C69T gene was significantly higher in healthy subjects compared to T2DMpatients (0.28 vs 0.45; p less than 0.0001; OR (95 percent CI) = 0.4624 (0.3732-0.5729), and therefore the T allele may be a protective factor against T2DM in the Saudi population.
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Kingdom of Saudi Arabia.
authors.forename: Khalid K
authors.initials: KK
authors.lastname: Alharbi
authors.forename: Imran Ali
authors.initials: IA
authors.lastname: Khan
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Al-Daghri
authors.forename: Anjana
authors.initials: A
authors.lastname: Munshi
authors.forename: Vandana
authors.initials: V
authors.lastname: Sharma
authors.forename: Abdul Khader
authors.initials: AK
authors.lastname: Mohammed
authors.forename: Kaiser A
authors.initials: KA
authors.lastname: Wani
authors.forename: Yazeed A
authors.initials: YA
authors.lastname: Al-Sheikh
authors.forename: May Salem
authors.initials: MS
authors.lastname: Al-Nbaheen
authors.forename: Mohammed Ghouse Ahmed
authors.initials: MG
authors.lastname: Ansari
authors.forename: Rabbani
authors.initials: R
authors.lastname: Syed
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012529:Saudi Arabia; D017422:Sequence Analysis, DNA
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1