title: Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population.
abstract: OBJECTIVE
  To assess the progression of attachment loss (AL) during a 2-year period according to the presence of JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population.
  
  
  METHODS
  A total of 500 adolescents (mean age 13.2 years, SD ± 1.5) were enrolled in the study. After 2 years, 397 (79.4%) returned for a periodontal re-examination, including the measurement of AL. The carrier status of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2 years earlier.
  
  
  RESULTS
  Individuals who carried the JP2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk (RR) = 7.3] of developing AL ≥ 3 mm. The mean AL at the follow-up and the mean 2-year progression of AL were significantly higher in the JP2 genotype-positive group (n = 38) compared with the group positive for the non-JP2 genotypes of A. actinomycetemcomitans (n = 169), and the group of A. actinomycetemcomitans-negative individuals (n = 190). The JP2 genotype was strongly associated with the progression of AL ≥ 3 mm (OR = 14.3). The non-JP2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL ≥ 3 mm (OR = 3.4).
  
  
  CONCLUSIONS
  The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL.
authors.affiliation: Division of Molecular Periodontology, Department of Odontology, Faculty of Medicine, Umeå University, Umeå, Sweden.
authors.forename: Carola
authors.initials: C
authors.lastname: Höglund Åberg
authors.forename: Francis
authors.initials: F
authors.lastname: Kwamin
authors.forename: Rolf
authors.initials: R
authors.lastname: Claesson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Dahlén
authors.forename: Anders
authors.initials: A
authors.lastname: Johansson
authors.forename: Dorte
authors.initials: D
authors.lastname: Haubek
mesh_terms: D000293:Adolescent; D016976:Aggregatibacter actinomycetemcomitans / Q000145:classification* / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D015331:Cohort Studies; D003603:Cytotoxins / Q000235:genetics; D003773:Dental Plaque / Q000382:microbiology; D018450:Disease Progression; D005098:Exotoxins / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005869:Ghana; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000382:microbiology* / Q000503:physiopathology; D011446:Prospective Studies; D012307:Risk Factors; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; D037521:Virulence Factors; C018579:leukotoxin
keywords: A. actinomycetemcomitans; Ghana; JP2 genotype; adolescent; attachment loss; leukotoxin; periodontitis; progression