title: Ecological study of hantavirus infection in wild rodents in an endemic area in Brazil.
abstract: A 3-year ecological study of small mammals was carried out in an endemic area for hantavirus pulmonary syndrome in the state of Santa Catarina in Southern Brazil. A total of 994 rodents of 14 different species corresponding to the subfamilies of Sigmodontinae, Murinae, Eumysopinae, and Caviinae were captured during 2004-2006. Oligoryzomys nigripes and Akodon montensis were the most abundant species and showed a clear seasonal pattern with higher population sizes during the winter. Rodent population outbreaks, associated within bamboo mast seeding events, were detected predominantly in areas where hantavirus pulmonary syndrome cases were notified in the state. Antibody reactivity to Hantavirus was detected in five sigmodontine species: O. nigripes (39/435), A. montensis (15/318), Akodon paranaensis (4/37), Thaptomys nigrita (1/86) and Sooretamys angouya (1/12). The highest hantavirus antibody prevalence occurred during the period of highest population size in A. montensis. For O. nigripes, hantavirus prevalence was higher in late spring, when reproduction was more frequent. Co-circulation of Juquitiba (JUQV) and Jabora (JABV) viruses was observed - JABV in A. paranaensis and A. montensis; JUQV in O. nigripes and T. nigrita. JABV occurrence was associated to gender and population size of the rodent while JUQV was related to gender, season, temperature, and locality.
authors.affiliation: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil. Electronic address: reoliveira@ioc.fiocruz.br.
authors.forename: Renata Carvalho
authors.initials: RC
authors.lastname: Oliveira
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Rosana
authors.initials: R
authors.lastname: Gentile
authors.affiliation: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Alexandro
authors.initials: A
authors.lastname: Guterres
authors.affiliation: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Jorlan
authors.initials: J
authors.lastname: Fernandes
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Bernardo Rodrigues
authors.initials: BR
authors.lastname: Teixeira
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Vanderson
authors.initials: V
authors.lastname: Vaz
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil; Departamento de Genética, Instituto Nacional de Câncer, INCA, Rio de Janeiro, Brazil.
authors.forename: Fernanda Pedone
authors.initials: FP
authors.lastname: Valdez
authors.affiliation: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Luciana Helena Bassan
authors.initials: LH
authors.lastname: Vicente
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Sócrates Fraga
authors.initials: SF
authors.lastname: da Costa-Neto
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil; Departamento de Genética, Instituto Nacional de Câncer, INCA, Rio de Janeiro, Brazil.
authors.forename: Cibele
authors.initials: C
authors.lastname: Bonvicino
authors.affiliation: Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Paulo Sergio
authors.initials: PS
authors.lastname: D'Andrea
authors.affiliation: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ-IOC, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Elba R S
authors.initials: ER
authors.lastname: Lemos
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006476:Orthohantavirus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D018804:Hantavirus Pulmonary Syndrome / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008297:Male; D011157:Population Dynamics; D015995:Prevalence; D012376:Rodent Diseases; D012377:Rodentia / Q000821:virology*; D012621:Seasons; D012737:Sex Factors
chemical_list: D000914:Antibodies, Viral
keywords: Hantavirus; Jabora virus; Juquitiba virus; Population ecology; Rodents