title: Comparison of embryo toxicity using two classes of aquatic vertebrates.
abstract: Toxicity tests of musk ketone (MK) and tetrabromobisphenol-A (TBBPA) on embryos were conducted in two amphibian species, Xenopus (Silurana) tropicalis and the Swedish native species Rana arvalis. TBBPA was also tested on fish embryos of Danio rerio. All species were tested in similar experimental setup. Musk ketone caused decreased heart rates at concentrations from 10 and 100 μg/L in R. arvalis and X. tropicalis, respectively. TBBPA caused effects at 1000 μg/L in all three species. The responses were comparable between all three species which supports the relevance for using data from non-native species in national risk assessment.
authors.affiliation: Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden. Electronic address: gunnar.carlsson@slu.se.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Carlsson
authors.affiliation: Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden.
authors.forename: Leif
authors.initials: L
authors.lastname: Norrgren
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D011898:Ranidae / Q000196:embryology*; D018570:Risk Assessment / Q000379:methods; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014981:Xenopus / Q000196:embryology*; D014992:Xylenes / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology
chemical_list: D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; D014992:Xylenes; C031448:musk ketone; C020806:tetrabromobisphenol A
keywords: Amphibians; Embryo; Fish; Toxicity