title: [Relationship between biochemical parameters of cerebrospinal fluid and the course of multiple sclerosis].
abstract: We examined 60 patients with remitting multiple sclerosis (disability 3,5±1.6 EDSS scores). The relative risk of rapid progression of neurologic impairment was associated with the higher levels of matrix metalloproteinase-2, soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the cerebrospinal fluid. The relative risk of exacerbation of the disease in the next three years was associated with the level of tumor necrosis factor alpha and matrix metalloproteinase-2.
authors.forename: I V
authors.initials: IV
authors.lastname: Smagina
authors.forename: S A
authors.initials: SA
authors.lastname: El'chaninova
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*; D019010:Vascular Cell Adhesion Molecule-1 / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1