title: Acquired pure red cell aplasia due to treatment with clopidogrel: first case report.
abstract: A 62-year-old woman with hypertension, type 2 diabetes mellitus, hyperlipemia and coronary heart disease started taking clopidogrel, with no addition of any other new drugs. However, with the addition of the drug, the patient was diagnosed as having acquired pure red cell aplasia (PRCA), and no any other inducing factors were detected from the patient. Furthermore, with the withdrawal of clopidogrel from the treatment, the patient recovered from the PRCA and did not recur. Therefore, we report PRCA as a rare side effect of clopidogrel for the first time.
authors.affiliation: Department of Pharmacy, Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Zhao-quan
authors.initials: ZQ
authors.lastname: Li
authors.forename: Qi-yu
authors.initials: QY
authors.lastname: Yang
authors.forename: Jia-dan
authors.initials: JD
authors.lastname: Yang
mesh_terms: D000077144:Clopidogrel; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy; D048909:Diabetes Complications / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine