title: Insights and perspectives on emerging inputs to weight of evidence determinations for food safety: workshop proceedings.
abstract: This workshop aimed to elucidate the contribution of computational and emerging in vitro methods to the weight of evidence used by risk assessors in food safety assessments. The following issues were discussed: using in silico and high-throughput screening (HTS) data to confirm the safety of approved food ingredients, applying in silico and HTS data in the process of assessing the safety of a new food ingredient, and utilizing in silico and HTS data in communicating the safety of food ingredients while enhancing the public's trust in the food supply. Perspectives on integrating computational modeling and HTS assays as well as recommendations for optimizing predictive methods for risk assessment were also provided. Given the need to act quickly or proceed cautiously as new data emerge, this workshop also focused on effectively identifying a path forward in communicating in silico and in vitro data.
authors.affiliation: PepsiCo Inc, 350 Columbus Ave, Valhalla, NY 10595, USA. Email: heidi.bialk@pepsico.com.
authors.forename: Heidi
authors.initials: H
authors.lastname: Bialk
authors.forename: Craig
authors.initials: C
authors.lastname: Llewellyn
authors.forename: Alison
authors.initials: A
authors.lastname: Kretser
authors.forename: Richard
authors.initials: R
authors.lastname: Canady
authors.forename: Richard
authors.initials: R
authors.lastname: Lane
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Barach
mesh_terms: D000818:Animals; D059022:Food Safety; D057166:High-Throughput Screening Assays; D006801:Humans; D018570:Risk Assessment
keywords: computational modeling; food supply; high-throughput screening; in silico; risk assessment; weight of evidence