title: Analysis of biochemical changes in rat erythrocytes induced by long-term simvastatin treatment.
abstract: Analysis of metabolic changes in rat erythrocytes against the background of long-term simvastatin treatment revealed an increase in glycolysis metabolite concentrations and glucose-6-phosphate dehydrogenase activity and oppositely directed shifts in antioxidant defense enzyme activities. It was demonstrated that hypoxia and imbalance in the antioxidant enzyme system contribute to the development of side effects of statins.
authors.affiliation: Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health Care of the Russian Federation, Russia. belousovalena@mail.ru.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Mikashinovich
authors.forename: E S
authors.initials: ES
authors.lastname: Belousova
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D019344:Lactic Acid / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D019821:Simvastatin / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; D019289:Pyruvic Acid; D019821:Simvastatin; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione