title: Effects of experimental desynchronosis on the organs of immune system in WAG and ISIAH rats.
abstract: We studied the influence of abnormal illumination regimen on cell composition of the central and peripheral organs of the immune system in ISIAH rats and control WAG rats. In ISIAH rats, 24-h illumination for 14 days led to more pronounced inhibition of cell proliferation and differentiation in the thymus and more pronounced decrease in splenocyte proliferation and T and B cell counts in the spleen in comparison with WAG rats; however, the level of antigen-presenting cells in the spleen of ISIAH increased. We concluded that ISIAH rats are more sensitive to abnormal illumination regimen than WAG rats. Twenty-four-hour illumination was associated with impairments of central differentiation of T cells and activation of systemic inflammation followed by impairment of differentiation regulation, which can aggravate metabolic dysfunctions in these animals.
authors.affiliation: Institute of Physiology, Siberian Branch of Russian Academy of Sciences; Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. anna_v_s@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Shurlygina
authors.forename: E V
authors.initials: EV
authors.lastname: Melnikova
authors.forename: N G
authors.initials: NG
authors.lastname: Panteleeva
authors.forename: M V
authors.initials: MV
authors.lastname: Tenditnik
authors.forename: M I
authors.initials: MI
authors.lastname: Dushkin
authors.forename: M V
authors.initials: MV
authors.lastname: Khrapova
authors.forename: V A
authors.initials: VA
authors.lastname: Trufakin
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000473:pathology / Q000528:radiation effects; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000528:radiation effects; D001794:Blood Pressure; D002454:Cell Differentiation; D002940:Circadian Rhythm / Q000276:immunology*; D015870:Gene Expression; D006973:Hypertension / Q000276:immunology / Q000473:pathology*; D007107:Immune System / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008027:Light; D008297:Male; D017440:Photoperiod; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000528:radiation effects; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects
chemical_list: D015703:Antigens, CD