title: Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy.
abstract: Recently, there has been growing emphasis on enhancing subjective quality of life (QOL), in addition to treating symptoms or extending one's life. However, the neurobiological basis of subjective QOL is unknown. To illuminate the neural substrates that inform subjective QOL, the association between prefrontal function and subjective QOL was explored in 72 healthy volunteers (40 women and 32 men; age, 45.1 ± 20.1 y), using 52-channel near-infrared spectroscopy (NIRS), a portable neuroimaging device that can measure brain function in a less-constrained condition. Results confirmed that subjective QOL was positively correlated with prefrontal hemodynamic response during a cognitive task and that subjective satisfaction regarding social relationships and in the physical domains were cardinal contributors to the association. These findings suggest that subjective QOL has possible involvement in prefrontal function and that NIRS potentially plays a role as a biological marker of subjective QOL.
authors.affiliation: a Department of Neuropsychiatry, Graduate School of Medicine , The University of Tokyo [Study Site] , Bunkyo-ku , Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Satomura
authors.forename: Ryu
authors.initials: R
authors.lastname: Takizawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Koike
authors.forename: Shingo
authors.initials: S
authors.lastname: Kawasaki
authors.forename: Akihide
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Eisuke
authors.initials: E
authors.lastname: Sakakibara
authors.forename: Yukika
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism*; D011788:Quality of Life; D019265:Spectroscopy, Near-Infrared; D014705:Verbal Behavior; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin