title: [Radio-induced breast morphoea: an unrecognized complication].
abstract: Morphoea is a localized scleroderma. Since the 1990s, it is described as a complication after irradiation for breast cancer. This complication is unrecognized and underdiagnosed. Irradiation seems to be a factor inducing an autoimmune process. Clinicians should be aware in case of an erythema in a treated area, appearing on average one year after the end of the irradiation. Histology alone can prove the diagnosis and rule out differential diagnoses: principally mastitis (carcinomatous, infectious), chronic radiodermatitis or radiation recall. Treatment of this rare complication is not consensual; it is most often topical steroids. The evolution is marked by a gradual decrease from the initial inflammation. Sclerosis persists, more or less substantially.
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Bauer
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: W
authors.initials: W
authors.lastname: Waisse
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Keller
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Pop
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Clavier
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Salze
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors.forename: G
authors.initials: G
authors.lastname: Noël
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001941:Breast Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001943:Breast Neoplasms / Q000532:radiotherapy*; D003646:Debridement; D018450:Disease Progression; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010789:Phototherapy; D011855:Radiodermatitis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D001323:Autoantibodies; D007166:Immunosuppressive Agents
keywords: Breast; Complication; Morphoea; Morphée; Radiotherapy; Radiothérapie; Sein; Side-effect