title: Cyclodextrin-based nanosponges: a propitious platform for enhancing drug delivery.
abstract: BACKGROUND
  Recently, Nanotechnology is receiving considerable acknowledgment due to its potential to combine features that are difficult to achieve by making use of a drug alone. Cyclodextrin-based nanosponges are yet another contemporary approach for highlighting the advancements which could be brought about in a drug delivery system. Statistical analyses have shown that around 40% of currently marketed drugs and about 90% of drugs in their developmental phase encounter solubility-related problems. Cyclodextrin-based nanosponges have the capacity to emerge as a productive approach over conventional cyclodextrins by overcoming the disadvantages associated with the latter.
  
  
  METHODS
  This review is intended to give an insight regarding cyclodextrin-based nanosponges such as their physical and chemical properties. In addition, methods of preparation and characterization are discussed along with biocompatibility, and how these nanomeric elements can be exploited in developing effective drug formulations.
  
  
  CONCLUSIONS
  This emerging technology of cyclodextrin-based nanosponges is expected to provide technical solutions to the formulation arena and to come up with some successful products in the pharmaceutical market. It also has an exciting future in the field of therapeutics wherein it can cater site-directed drug delivery and hence it possesses vibrant opportunities.
authors.affiliation: University of Mumbai, Bharati Vidyapeeth's College of Pharmacy, Department of Pharmaceutics , Sector 8, C B D Belapur, Navi Mumbai 400 614 , India +91 022 27571122 ; +91 022 27574525 ; krj24@rediffmail.com.
authors.forename: Sai V
authors.initials: SV
authors.lastname: Chilajwar
authors.forename: Priti P
authors.initials: PP
authors.lastname: Pednekar
authors.forename: Kisan R
authors.initials: KR
authors.lastname: Jadhav
authors.forename: Gajendra J C
authors.initials: GJ
authors.lastname: Gupta
authors.forename: Vilasrao J
authors.initials: VJ
authors.lastname: Kadam
mesh_terms: D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004364:Pharmaceutical Preparations