title: Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors.
abstract: Despite its abundant expression in the brain, the cannabinoid type-1 (CB1) receptor was discovered only in 1988. During the last decade, efforts from several research groups have made it possible to visualize the CB1 receptor in vivo to unravel its role in the brain physiology and pathology. This review discusses strategies for (radio)synthesis of radioligands for in vivo imaging of CB1 receptors.
authors.affiliation: Laboratory for Radiopharmacy, IMIR KU Leuven, O&N2, Herestraat 49, Box 821, BE-3000, Leuven, Belgium.
authors.forename: Muneer
authors.initials: M
authors.lastname: Ahamed
authors.forename: Alfons
authors.initials: A
authors.lastname: Verbruggen
authors.forename: Guy
authors.initials: G
authors.lastname: Bormans
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D063386:Cannabinoid Receptor Agonists / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000378:metabolism*
chemical_list: D063386:Cannabinoid Receptor Agonists; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D043884:Receptor, Cannabinoid, CB1
keywords: CB1 receptors; in vivo imaging; positron emission tomography; radiosynthesis