title: Common and specific associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies in systemic lupus erythematosus.
abstract: Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and P = 0.019, resp.) and anti-Ro52/TRIM21 (P = 0.026 and P = 0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P = 0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P = 0.041), mainly with low C4 levels (P = 0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud's phenomenon (P = 0.026) and cytopenia (P = 0.048) and negatively associated with anti-dsDNA (P = 0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P = 0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.
authors.affiliation: Department of Immunology, Hospital Universitario Central de Asturias, Celestino Villamil S/N, 33006 Oviedo, Spain.
authors.forename: Aurora
authors.initials: A
authors.lastname: Menéndez
authors.forename: Jesús
authors.initials: J
authors.lastname: Gómez
authors.forename: Luis
authors.initials: L
authors.lastname: Caminal-Montero
authors.forename: José Bernardino
authors.initials: JB
authors.lastname: Díaz-López
authors.forename: Iván
authors.initials: I
authors.lastname: Cabezas-Rodríguez
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mozo
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood; D003176:Complement C3 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology*; D008231:Lymphopenia / Q000209:etiology / Q000276:immunology; D008297:Male; D019226:Oral Ulcer / Q000209:etiology / Q000276:immunology; D010641:Phenotype; D010787:Photosensitivity Disorders / Q000209:etiology / Q000276:immunology; D011928:Raynaud Disease / Q000209:etiology / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D014985:Xerophthalmia / Q000209:etiology / Q000276:immunology; D014987:Xerostomia / Q000209:etiology / Q000276:immunology; D055815:Young Adult; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D003176:Complement C3; D003181:Complement C4; D016682:Lupus Coagulation Inhibitor; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C035356:SS-A antibodies