title: Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis.
abstract: Microfluidic systems are currently receiving a lot of attention in the PET radiochemistry field, due to their demonstrated ability to obtain higher incorporation yields with reduced total processing time and using a decreased amount of precursors. The Advion NanoTek LF was the first commercial microfluidic system available for radiochemistry that allows basic parameter optimization to be performed. In this paper we report hardware and software modifications that would allow better performing procedures, higher product throughput and flexibility to utilize the system. In particular, HPLC purification and SPE formulation have been fully integrated.
authors.affiliation: LifeSciences Division, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234, Australia; Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: gianp@ansto.gov.au.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pascali
authors.affiliation: Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Berton
authors.affiliation: Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: DeSimone
authors.affiliation: LifeSciences Division, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234, Australia.
authors.forename: Naomi
authors.initials: N
authors.lastname: Wyatt
authors.affiliation: LifeSciences Division, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234, Australia.
authors.forename: Lidia
authors.initials: L
authors.lastname: Matesic
authors.affiliation: LifeSciences Division, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234, Australia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Greguric
authors.affiliation: Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
authors.forename: Piero A
authors.initials: PA
authors.lastname: Salvadori
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004867:Equipment Design; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D044085:Microfluidics / Q000295:instrumentation; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011854:Radiochemistry / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012984:Software; D052616:Solid Phase Extraction
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals
keywords: (18)F-fluoride; Advion NanoTek; Dose On Demand; Microfluidic radiochemistry; PET