title: Home cage locomotor changes in non-human primates after prolonged welding-fume exposure.
abstract: To define the relationship between the brain concentration of manganese and neurological signs, such as locomotion, after prolonged welding-fume exposure, cynomolgus monkeys were acclimated for 1 month and then divided into three concentration groups: unexposed, low concentration (31 mg/m(3) total suspended particulate (TSP), 0.9 mg/m(3) of Mn), and high concentration (62 mg/m(3) TSP, 1.95 mg/m(3) of Mn) of TSP. The monkeys were exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h per day over 8 months in an inhalation chamber system equipped with an automatic fume generator. The home cage locomotor activity and patterns were determined using a camera system over 2-4 consecutive days. After 25 and 32 weeks of exposure, the home cage locomotor activity of the high-concentration primates was found to be 5-6 times higher than that of the unexposed primates, and this increased locomotor activity was maintained for 7 weeks after ceasing the welding-fume exposure, eventually subsiding to three times higher after 13 weeks of recovery. Therefore, the present results, along with our previous observations of a high magnetic resonance imaging (MRI) T1 signal in the globus pallidus and increased blood Mn concentration, indicate that prolonged welding-fume exposure can cause neurobehavioral changes in cynomolgus monkeys.
authors.affiliation: Daegu-Gyeongbuk Medical Innovation Foundation , Daegu , Korea .
authors.forename: Choong Yong
authors.initials: CY
authors.lastname: Kim
authors.forename: Jae Hyuck
authors.initials: JH
authors.lastname: Sung
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Chung
authors.forename: Jung Duck
authors.initials: JD
authors.lastname: Park
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Han
authors.forename: Jong Seong
authors.initials: JS
authors.lastname: Lee
authors.forename: Jeong Doo
authors.initials: JD
authors.lastname: Heo
authors.forename: Il Je
authors.initials: IJ
authors.lastname: Yu
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D008252:Macaca fascicularis; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects; D014896:Welding
chemical_list: D000393:Air Pollutants; D019216:Metals, Heavy