title: Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs.
abstract: Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed  on the basis of  FT-IR, 1H-NMR, 13C-NMR and mass spectral data. The COX-2 inhibition screening assay revealed that 4-[(E)-2-{3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl}ethenyl]benzene-1-sulfonamide had a  maximum COX-2 inhibition (47.1%), at a concentration of 20 μM.
authors.affiliation: Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia. hayun.ms@ui.ac.id.
authors.forename: Sumi
authors.initials: S
authors.lastname: Hudiyono
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanafi
authors.forename: Arry
authors.initials: A
authors.lastname: Yanuar