title: The evaluation of Lugol's iodine solution staining combined with endoscope for diagnosis of non-erosive reflux disease in clinic.
abstract: OBJECTIVE
  To evaluate the value of Lugol's iodine solution staining combined with endoscope on the diagnosis of non-erosive reflux disease (NERD).
  
  
  METHODS
  A total of 96 gastroesophageal reflux disease patients were selected to participate in this study. The patients were stained on esophageal mucosa by Lugol's iodine solution and examined at routine endoscopy. The shallow staining and/or non-staining group patients were treated with esomeprazole and mosapride citrate, and then the changes in Lugol's iodine staining, Gerd Q (Gerd questionnaire) scoring and histological characters of esophageal mucosa were recorded before and after treatment.
  
  
  RESULTS
  As the results, a total of 68 patients were diagnosed as NERD, and 36 of 68 patients were observed with uniform staining and 32 of 68 patients were observed with shallow staining and/or non-staining. After 4 weeks for treatment, 28 of 32 patients with shallow staining and/or non-staining became uniform staining and 4 of 32 patients were still with shallow staining and/or non-staining. Before and after treatment, the Gerd Q scoring of uniform staining groups and shallow staining and/or non-staining groups all had a significant difference (p < 0.05). Compared to the routine endoscopy, the detection rate of abnormal esophageal mucosa was significantly increased by Lugol's iodine solution staining combined with endoscope.
  
  
  CONCLUSIONS
  Lugol's iodine solution staining combined with routine endoscopy, Gerd Q scoring and histomorphology can be used to evaluate the diagnosis and therapeutic effect of NERD.
authors.affiliation: Department of Gastroenteroloy, Qilu Hospital, Shandong University, Jinan, Shandong Province, China. liyanqing@sdu.edu.cn  
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Xue
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: H-Y
authors.initials: HY
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: X-H
authors.initials: XH
authors.lastname: Song
authors.forename: Y-X
authors.initials: YX
authors.lastname: He
authors.forename: T
authors.initials: T
authors.lastname: Yang
authors.forename: C-Q
authors.initials: CQ
authors.lastname: Li
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Li
mesh_terms: D000328:Adult; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007454:Iodides; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling
chemical_list: D007454:Iodides; C010389:Lugol's solution