title: Streptokinase therapy in the treatment of neonatal obstructive renal candidiasis.
abstract: A 6-week-old ex-25-week gestation male infant developed candidal sepsis with subsequent bilateral acute obstructive nephropathy that was not responsive to intravenous antifungal therapy. Bilateral percutaneous nephrotomies were performed and irrigation with fluconazole started. Owing to the persistence of the candidaemia and left renal obstruction, streptokinase was administered through the nephrostomy with eventual resolution of obstruction and improvement in his kidney function. This case report discusses the use of the streptokinase therapy as an adjunct therapy in the clearance of fungal bezoars.
authors.affiliation: Royal Hospital for Women, Randwick, New South Wales, Australia.
authors.forename: Kee Thai
authors.initials: KT
authors.lastname: Yeo
authors.forename: Archana
authors.initials: A
authors.lastname: Priyadarshi
authors.forename: Srinivas
authors.initials: S
authors.lastname: Bolisetty
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D009403:Nephrostomy, Percutaneous; D012076:Renal Agents / Q000627:therapeutic use*; D013300:Streptokinase / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D012076:Renal Agents; D013300:Streptokinase