title: [Management of chronic migraine in Japan].
abstract: The Japanese Headache Society and the Japanese Society of Neurology has published the 2013 guidelines for the diagnosis and treatment of chronic headache. A new CQ has been set up in the guidelines on the topic of "How to treat chronic migraine." In the past, lomerizine was the only prophylactic medication of migraine that was eligible under insurance coverage. However, afterward in 2010, valproate was added to the list of antimigraine medications approved under insurance coverage, followed by propranolol, amitriptyline, and verapamil, with rapid advances in the treatment of migraine. Valproate, topiramate (not approved under insurance coverage until date), and amitriptyline could potentially be used in the treatment of chronic migraine in Japan; further, considering the clinical outcomes thus far, lomerizine could also be added to the list. As a drug for migraine prophylaxis, valproate is contraindicated in pregnant women and needs to be used with caution.
authors.affiliation: Department of Neurology, Dokkyo Medical University.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Takashima
authors.forename: Hisatake
authors.initials: H
authors.lastname: Iwanami
authors.forename: Shiho
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hisaka
authors.initials: H
authors.lastname: Igarashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D002908:Chronic Disease; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy*