title: Derivatives of salarin A, salarin C and tulearin A--Fascaplysinopsis sp. metabolites.
abstract: Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
authors.affiliation: School of Chemistry, Tel Aviv University, Ramat Aviv 69978, Israel. kashman@post.tau.ac.il.
authors.forename: Lee Goren
authors.initials: LG
authors.lastname: Zur
authors.forename: Ashgan
authors.initials: A
authors.lastname: Bishara
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
authors.forename: Drorit
authors.initials: D
authors.lastname: Neumann
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ben-Califa
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D020014:K562 Cells; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C526618:salarin A; C571877:salarin C; C526620:tulearin