title: Signs of cell-cell interactions in sarcoma 45 tissue under conditions of antitumor effect caused by injection of magnetite nanoparticles.
abstract: Changes in transplanted sarcoma 45 tissue in outbred albino rats with tumor regression under the effect of magnetite nanoparticles (magnetic fluid) were studied by light and electron microscopy. The ultrastructure and cell death types in regressing tumors and signs of cell-cell interactions with participation of macrophages, lymphocytes, neutrophils, and degranulating mast cells were described. Some possible mechanisms of a pronounced antitumor activity of magnetite nanoparticles were discussed.
authors.affiliation: Rostov Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. galya_57@mail.ru.
authors.forename: T N
authors.initials: TN
authors.lastname: Gudtskova
authors.forename: G V
authors.initials: GV
authors.lastname: Zhukova
authors.forename: M I
authors.initials: MI
authors.lastname: Bragina
authors.forename: L Kh
authors.initials: LKh
authors.lastname: Garkavi
authors.forename: A I
authors.initials: AI
authors.lastname: Mikholap
authors.forename: T A
authors.initials: TA
authors.lastname: Barteneva
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002450:Cell Communication; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D007962:Leukocytes / Q000276:immunology; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D008297:Male; D009368:Neoplasm Transplantation; D010587:Phagocytosis; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles