title: Synthesis, characterization and antibacterial and antifungal evaluation of some para-quinone derivatives.
abstract: Some novel Pyrrolo [2,3-f] Indole-3,7-Dicarbonitrile derivatives (1-5) were synthesized using chloranil, malononitrile and anilines. The structures of the newly synthesized compounds were characterized by elemental analysis, FT-IR, (1)H- and (13)C-NMR and mass spectroscopy. These compounds were screened for in vitro antibacterial and antifungal activities against some human pathogenic micro-organisms by employing the disc diffusion technique. Some of the compounds showed moderate to good biological activities when compared with standard drugs.
authors.affiliation: Department of Chemistry, Shiraz University of Technology, Shiraz, Iran.
authors.forename: A M
authors.initials: AM
authors.lastname: Amani
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011809:Quinones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007202:Indicators and Reagents; D011809:Quinones