title: Ethyl glyoxylate N-tosylhydrazone as sulfonyl-transfer reagent in base-catalyzed sulfa-Michael reactions.
abstract: Ethyl glyoxylate N-tosylhydrazone has been identified as an excellent sulfonyl anion surrogate in the DBU-catalyzed conjugate addition reaction with enones and enals for the synthesis of functionalized sulfones. The reaction proceeds under base-catalyzed conditions and provides a direct access to γ-keto- and γ-hydroxy sulfones in a simple and reliable way through a sulfa-Michael reaction that proceeds with high yield and chemoselectivity.
authors.affiliation: Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU , P.O. Box 644, E-48080 Bilbao, Spain.
authors.forename: Maitane
authors.initials: M
authors.lastname: Fernández
authors.forename: Uxue
authors.initials: U
authors.lastname: Uria
authors.forename: Lucia
authors.initials: L
authors.lastname: Orbe
authors.forename: Jose L
authors.initials: JL
authors.lastname: Vicario
authors.forename: Efraím
authors.initials: E
authors.lastname: Reyes
authors.forename: Luisa
authors.initials: L
authors.lastname: Carrillo