title: TERT genetic polymorphism rs2736100 was associated with lung cancer: a meta-analysis based on 14,492 subjects.
abstract: BACKGROUND
  Previous studies focused on the association of the telomerase reverse transcriptase (TERT) gene polymorphism rs2736100 with lung cancer did not reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between TERT polymorphism rs2736100 and the risk for lung cancer.
  
  
  METHODS
  We conducted a search of case-control studies on the association of TERT with susceptibility to lung cancer in PubMed, EMBASE, ISI Web of Science, Wanfang database in China, and Chinese National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted for meta-analysis. Lung cancer risk associated with rs2736100 was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).
  
  
  RESULTS
  Six independent case-control studies on rs2736100 were included in our meta-analysis. Our results showed that rs2736100 was associated with the risk of lung cancer not only in an additive model (OR=1.19, 95% CI: 1.04-1.35; p=0.01), but also in a dominant model (OR=1.14, 95% CI: 1.01-1.28; p=0.03).
  
  
  CONCLUSIONS
  This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
authors.affiliation: Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai, People's Republic of China .
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Wang
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000235:genetics*; D039781:PubMed; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins; C509186:TERT protein, human; D019098:Telomerase