title: Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.
abstract: Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
authors.forename: Heidi C
authors.initials: HC
authors.lastname: Smith-Vaughan
authors.forename: Anne B
authors.initials: AB
authors.lastname: Chang
authors.forename: Derek S
authors.initials: DS
authors.lastname: Sarovich
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Marsh
authors.forename: Keith
authors.initials: K
authors.lastname: Grimwood
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Leach
authors.forename: Peter S
authors.initials: PS
authors.lastname: Morris
authors.forename: Erin P
authors.initials: EP
authors.lastname: Price
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics*; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D005798:Genes, Bacterial; D014943:Global Health; D006192:Haemophilus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000276:immunology* / Q000302:isolation & purification; D006193:Haemophilus influenzae / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny
chemical_list: D000942:Antigens, Bacterial; D004269:DNA, Bacterial; D018073:Haemophilus Vaccines