title: The role of cognitive event-related potentials in executive dysfunction.
abstract: Frontal lobes are great and are a late-developing region of the neocortex that play a critical role in human behavior and executive function. The aim of this study was to clarify the role of event-related potentials (ERPs) in executive dysfunction and its relationship between generator mechanism and cognitive significance. We recruited 20 patients with frontal lobe lesion (FLL) and 27 age-matched controls. All patients submitted to comprehensive Frontal Test Battery and auditory ERPs measurement. In comparison with controls, the patients with FLL had significantly decreased executive function and manifested the delay of P300 latency, which reflected a delay of mental processing speed in these patients. Our findings suggest that patients with FLL may have prolonged P300 latency, which has a good correlation with executive dysfunction, poor performance, and longer P300 latencies. P300 ERPs are considered to be a useful method to identify the alteration of frontal-parietal connection.
authors.affiliation: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Chiou-Lian
authors.initials: CL
authors.lastname: Lai
authors.forename: Ruey-Tay
authors.initials: RT
authors.lastname: Lin
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Liou
authors.forename: Yuan-Han
authors.initials: YH
authors.lastname: Yang
authors.forename: Ching-Kuan
authors.initials: CK
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003071:Cognition; D005071:Evoked Potentials; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Event-related potential; Executive function; Frontal lesion; P300