title: Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.
abstract: Curcumin is well known as an antioxidant and anti-inflammatory agent. In this study, we provided convincing evidence for the function of curcumin in neurite outgrowth of cortical neurons. We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signal-regulated kinase (ERK) 1/2 antagonist. Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown. Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway.
authors.affiliation: Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid Wulumuqi Road, Shanghai 200040, PR China; Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid Wulumuqi Road, Shanghai 200040, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid Wulumuqi Road, Shanghai 200040, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China. Electronic address: drzhaohong@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid Wulumuqi Road, Shanghai 200040, PR China. Electronic address: qiang_dong163@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology*; D055785:Gene Knockdown Techniques; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000235:genetics*; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D016501:Neurites / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D008565:Membrane Proteins; C106354:flotillins; D003474:Curcumin
keywords: Curcumin; Extracellular signal-regulated kinase; Neurite outgrowth; Reggie-1/flotillin-2