title: [The phenomenon of vascular microthrombosis in mucoperichondrium associated with plastic closure of nasal septum perforations].
abstract: The objective of the present study was to identify specific hematological features characterizing the pathophysological processes of clinical significance associated with plastic closure of nasal septum perforations. Changes of clinical, biochemical, and coagulation-related blood characteristics developing as a result of the surgical treatment of the patients with ENT pathology were analysed. It was shown that D-dimer is a specific hematological characteristic that reflects the phenomenon of postoperative vascular microthrombosis in mucoperichondrial-periosteal flaps associated with plastic closure of nasal septum perforations. Based on the results of this study, the authors recommend to prescribe low-molecular weight heparins for prophylactic purposes to the patients undergoing plastic closure of nasal septum perforations.
authors.forename: A I
authors.initials: AI
authors.lastname: Kriukov
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Tsarapkin
authors.forename: O V
authors.initials: OV
authors.lastname: Margolin
authors.forename: E V
authors.initials: EV
authors.lastname: Gorovaia
authors.forename: K M
authors.initials: KM
authors.lastname: Fedotkina
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000098:blood supply* / Q000601:surgery; D061270:Nasal Septal Perforation / Q000601:surgery*; D009300:Nasal Septum / Q000098:blood supply* / Q000601:surgery; D011183:Postoperative Complications; D012225:Rhinoplasty / Q000009:adverse effects*; D013524:Surgical Flaps; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight