title: A phase I open-label study to investigate the potential drug-drug interaction between single-dose dacomitinib and steady-state paroxetine in healthy volunteers.
abstract: Dacomitinib is currently in development for the treatment of non-small cell lung cancer. Formation of the major circulating metabolite (PF-05199265) is mediated by cytochrome P450 (CYP) 2D6 and CYP2C9. This phase I, single fixed-sequence, two-period study evaluated the effect of paroxetine, a CYP2D6 inactivator, on dacomitinib pharmacokinetics in healthy volunteers who were extensive CYP2D6 metabolizers. Subjects received a single 45-mg dacomitinib dose alone and in combination with paroxetine (30 mg/day for 10 consecutive days, with dacomitinib administered on day 4) at steady-state levels. Blood samples were collected through 240 hours post-dacomitinib dosing. Dacomitinib exposure (area under the concentration-time curve from 0 to infinity; AUCinf) increased 37%; however a reduction in PF-05199265 AUCinf of approximately 90% was observed during the paroxetine treatment period. The maximum concentration of dacomitinib changed minimally. Adverse events reported with single-dose dacomitinib administered alone or in the presence of steady-state levels of paroxetine were mostly mild, and no serious adverse events were reported. While paroxetine significantly inhibited CYP2D6-mediated metabolism of a single dose of dacomitinib, the modest effect on dacomitinib exposure is unlikely to be clinically relevant when dacomitinib is given daily. Dose adjustment of dacomitinib may therefore not be required upon coadministration with a CYP2D6 inhibitor.
authors.affiliation: Pfizer, Inc, La Jolla, CA, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Ruiz-Garcia
authors.affiliation: Pfizer, Inc, La Jolla, CA, USA.
authors.forename: Nagdeep
authors.initials: N
authors.lastname: Giri
authors.affiliation: Pfizer, Inc, Groton, CT, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: LaBadie
authors.affiliation: Pfizer, Inc, Groton, CT, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Ni
authors.affiliation: Pfizer, Inc, La Jolla, CA, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Boutros
authors.affiliation: Pfizer, Inc, Cambridge, MA, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Richie
authors.affiliation: Pfizer, Inc, New Haven, CT, USA.
authors.forename: Hetal S
authors.initials: HS
authors.lastname: Kocinsky
authors.affiliation: Pfizer, Inc, Groton, CT, USA.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Checchio
authors.affiliation: Pfizer, Inc, New York, NY, USA.
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Bello
mesh_terms: D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D065690:Cytochrome P-450 CYP2D6 Inhibitors / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D052999:Quinazolinones / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D065690:Cytochrome P-450 CYP2D6 Inhibitors; D052999:Quinazolinones; D017374:Paroxetine; C525726:dacomitinib; D019389:Cytochrome P-450 CYP2D6
keywords: CYP2D6; Dacomitinib; drug interaction; healthy volunteers; paroxetine