title: Antibody response to human papillomavirus vaccine in subjects with inherited bone marrow failure syndromes.
abstract: Patients with Fanconi anemia (FA) and other inherited bone marrow failure syndromes (IBMFS) have extremely high risks of squamous cell head and neck, and gynecologic carcinomas. In the general population, these sites are often associated with infection with human papillomaviruses (HPV), particularly HPV16 and HPV18. Our objectives were to measure the levels of HPV antibodies in unvaccinated patients, and to determine whether these patients developed and maintained similar levels of antibodies as those observed in healthy women, following vaccination with the currently licensed HPV L1 virus-like particles (VLP) vaccines. We measured anti-HPV IgG antibody levels in sera from patients using an HPV16 or HPV18 L1 VLP enzyme-linked immunoabsorbent assay. Most unvaccinated patients did not have detectable antibody levels, except for a few women above age 25. Both FA and other IBMFS patients developed antibody levels following vaccination that were similar to those previously described in healthy women, and those levels appeared to be sustained out to 5 years after immunization. Thus, antibody responses to the HPV L1 VLP vaccine in patients with FA and other IBMFS appeared to be similar to the responses reported in the general population, implying potential efficacy against future infections with the HPV types contained in the vaccine.
authors.affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Electronic address: alterb@mail.nih.gov.
authors.forename: Blanche P
authors.initials: BP
authors.lastname: Alter
authors.affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA.
authors.forename: Neelam
authors.initials: N
authors.lastname: Giri
authors.affiliation: HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
authors.forename: Yuanji
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA.
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Savage
authors.affiliation: HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
authors.forename: Ligia A
authors.initials: LA
authors.lastname: Pinto
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D001855:Bone Marrow Diseases; D000080983:Bone Marrow Failure Disorders; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005199:Fanconi Anemia / Q000276:immunology*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D053918:Papillomavirus Vaccines
keywords: Fanconi anemia; Human papillomavirus; Inherited bone marrow failure syndromes; Vaccine; dyskeratosis congenita