title: Sinus arrest and asystole caused by a peripherally inserted central catheter.
abstract: BACKGROUND
  Transient bradycardia in the critical care setting is frequently caused by hypoxemia or oropharyngeal manipulation. Central lines have been associated with a variety of cardiac arrhythmias, but sinus arrest and asystole have not been previously reported.
  
  
  METHODS
  A 38-year-old woman with multisystem organ failure had several episodes of prolonged sinus arrest, slow junctional escape rhythm, and periods of asystole lasting over 6 seconds. The cause of the repetitive bradyarrhythmia was evaluated by clinical observation including the response to parasympatholytic agents, by detailed analysis of rhythm strips, and review of cardiac imaging studies.
  
  
  RESULTS
  The episodes of bradycardia did not coincide with orotracheal manipulation, were not prevented by escalating doses of glycopyrrolate, and were not accompanied by AV conduction disturbance as is frequently seen during a transient increase in vagal tone. Review of the patient's chest X-ray and chest CT revealed that the tip of a peripherally inserted central catheter migrated to the vicinity of the sinoatrial node. Removal of the catheter resulted in prompt resolution of the episodes of sinus arrest.
  
  
  CONCLUSIONS
  This case demonstrates that migration of a peripherally inserted central catheter to the sinoatrial node can provoke prolonged sinus bradycardia, sinus arrest and asystole.
authors.affiliation: Department of Internal Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Nazinitsky
authors.forename: Melody
authors.initials: M
authors.lastname: Covington
authors.forename: Laszlo
authors.initials: L
authors.lastname: Littmann
mesh_terms: D000328:Adult; D001919:Bradycardia / Q000209:etiology* / Q000503:physiopathology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D005260:Female; D006323:Heart Arrest / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D009102:Multiple Organ Failure / Q000503:physiopathology
keywords: asystole; catheter migration; intensive care unit; peripherally inserted central catheter; sinus arrest