title: Comparison of the effects of dexmedetomidine and remiphentanyl on emergence agitation after sevoflurane anesthesia in adults undergoing septoplasty operation: a randomized double-blind trial.
abstract: OBJECTIVE
  Sevoflurane is an ideal agent for anesthesia since its respiratory irritant effect is minimal during mask induction. Emergence agitation (EA) is a common problem after anesthesia with sevoflurane. In this study it was aimed to compare the effects of dexmedetomidine and remifentanyl on emergence agitation after sevoflurane anesthesia in adults undergoing septoplasty operation.
  
  
  METHODS
  This prospective, randomized, double-blind study was conducted in Yenimahalle State Hospital after obtaining local Ethics Committee approval and patient's written informed consent. The patients were randomized into dexmedetomidine and remifentanyl groups. Hemodynamic parameters including heart rat, Mean arterial pressure, and sPO2 were recorded. The patients were followed for 1 hour at the recovery room. Categorical data was analyzed using c2 test. Hemodynamic data was evaluated using unpaired t test for intergroup and paired t-test for within group comparisons. Data not normally distributed was compared using Mann Whitney U test. p < 0.05 was considered statistically significant.
  
  
  RESULTS
  Demographic data were similar in both groups (p > 0.05). Riker score was similar in both groups. VAS score was also not significantly different between both groups at the recovery room.
  
  
  CONCLUSIONS
  Our study demonstrated that Dexmedotimidine and Remifentanyl had equal effectiveness in reducing emergence agitation in patients undergoing septoplasty under Sevoflurane anesthesia.
authors.affiliation: Department of Anesthesia, Yenimahalle State Hospital, Ankara, Turkey. gkavalci@yahoo.com  
authors.forename: G
authors.initials: G
authors.lastname: Kavalci
authors.forename: F B
authors.initials: FB
authors.lastname: Ethemoglu
authors.forename: P
authors.initials: P
authors.lastname: Durukan
authors.forename: A
authors.initials: A
authors.lastname: Batuman
authors.forename: C
authors.initials: C
authors.lastname: Emre
mesh_terms: D000328:Adult; D000368:Aged; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D009300:Nasal Septum / Q000601:surgery*; D010880:Piperidines / Q000627:therapeutic use*; D011446:Prospective Studies; D011595:Psychomotor Agitation / Q000209:etiology / Q000517:prevention & control*; D000077208:Remifentanil; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D020927:Dexmedetomidine; D000077208:Remifentanil