title: Noninvasive brain stimulation can elucidate and interact with the mechanisms underlying motor learning and retention: implications for rehabilitation.
abstract: Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor learning paradigm, Cantarero et al. (J Neurosci 33: 12862-12869, 2013) recently provided novel evidence to support the hypothesis that retention of motor skill is contingent upon this postlearning occlusion.
authors.affiliation: Human Motor Control Laboratory, School of Medicine, University of Tasmania, Australia;
authors.forename: Mark R
authors.initials: MR
authors.lastname: Hinder
authors.forename: Paola
authors.initials: P
authors.lastname: Reissig
authors.forename: Hakuei
authors.initials: H
authors.lastname: Fujiyama
mesh_terms: D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*
keywords: brain plasticity; motor cortex; motor learning and retention; transcranial magnetic stimulation