title: Propylthiouracil-induced bronchiolitis obliterans organizing pneumonia.
abstract: Propylthiouracil (PTU) is commonly used to treat hyperthyroidism. However, it is also associated with a number of adverse events. In particular, pulmonary complications, although rare, can be serious. Therefore, early detection is paramount. We herein describe a first case of PTU-induced bronchiolitis obliterans organizing pneumonia (BOOP) pathologically confirmed on a surgical lung biopsy. The present case shows that early detection coupled with the immediate withdrawal of PTU can lead to a successful resolution of symptoms and radiographic abnormalities without the need for corticosteroids. Although rare, PTU-induced BOOP should be considered in the differential diagnosis of pulmonary opacity in patients receiving PTU therapy.
authors.affiliation: Department of Internal Medicine, Kyungpook National University, School of Medicine, South Korea.
authors.forename: Jaehee
authors.initials: J
authors.lastname: Lee
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Choi
authors.forename: Keum Ju
authors.initials: KJ
authors.lastname: Choi
authors.forename: Seung Ick
authors.initials: SI
authors.lastname: Cha
authors.forename: Tae In
authors.initials: TI
authors.lastname: Park
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kim
mesh_terms: D013956:Antithyroid Agents / Q000009:adverse effects*; D001706:Biopsy; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil