title: Peniciketals A-C, new spiroketals from saline soil derived Penicillium raistrichii.
abstract: Peniciketals A-C (1-3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii. Their structures including absolute configurations were established by NMR, X-ray diffraction, and ECD calculations. Their cytotoxicities were tested against A549, HL-60, and K562 cell lines, and 1-3 showed the selective effects on HL-60 cells with IC50 values of 3.2, 6.7, and 4.5 μM, respectively.
authors.affiliation: Pharmacy of College, Binzhou Medical College , Yantai 264003, People's Republic of China.
authors.forename: Wei-Zhong
authors.initials: WZ
authors.lastname: Liu
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Ma
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Liu
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Shou-Sen
authors.initials: SS
authors.lastname: Shi
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Pan
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Song
authors.forename: Rong-Xiu
authors.initials: RX
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011789:Quantum Theory; D054712:Salinity; D012987:Soil / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011714:Pyrans; D012987:Soil; D013141:Spiro Compounds; C587991:peniciketal A; C587990:peniciketal B; C587992:peniciketal C