title: Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl.
abstract: Novel mucoadhesive beads containing metformin HCl made of low methoxy (LM) pectin-tamarind seed polysaccharide (TSP) polymer-blend was developed through ionotropic-gelation technique and optimized using 3(2) factorial design. Effects of LM pectin and TSP amounts on drug encapsulation efficiency (DEE), and cumulative drug release at 10h (R10h) were analyzed using response surface methodology. The optimized calcium pectinate-TSP beads containing metformin HCl showed DEE of 95.12 ± 4.26%, R10h of 46.53 ± 3.28%, and mean diameter of 1.93 ± 0.26 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. These beads were also characterized by SEM and FTIR. The optimized beads also exhibited pH-dependent swelling, good mucoadhesivity with goat intestinal mucosa and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757 086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.forename: Kousik
authors.initials: K
authors.lastname: Santra
mesh_terms: D000268:Adhesiveness; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010368:Pectins; D008687:Metformin
keywords: Controlled drug release; Ionotropic-gelation; Metformin HCl; Mucoadhesion; Pectin; Tamarind seed polysaccharide