title: Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum.
abstract: Much attention has been paid to cholestane-type steroidal glycosides because of their importance from the perspectives of both chemical diversity and significant biological activities. A phytochemical investigation of the rhizomes of Polygonatum odoratum (Liliaceae) resulted in the isolation of three novel cholestane-type steroidal glycosides (1-3) with unique Δ(14,16)-unsaturated D-ring structures as well as two novel spirostane-type steroidal saponins (4 and 5) and three known steroidal glycosides (6-8). Their structures were determined by various spectroscopic methods and chemical reactions. Steroidal saponin 7 showed significant antifungal activity against Candida albicans JCM1542 (MIC 3.1 μg/mL) and Aspergillus fumigatus JCM1738 (MIC 6.3 μg/mL).
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China. Electronic address: baihong@gmail.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Bai
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan. Electronic address: liwei@phar.toho-u.ac.jp.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Anzai
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
authors.forename: Huanjie
authors.initials: H
authors.lastname: Guo
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Kato
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
mesh_terms: D002776:Cholestanes / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D031384:Polygonatum / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D002776:Cholestanes; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D013150:Spirostans
keywords: Antifungal activity; Cholestane glycosides; Polygonatum odoratum; Spirostane saponins