title: The influence of HIV status on prenatal genetic diagnosis choices.
abstract: BACKGROUND
  At-risk women of advanced maternal age (AMA) can choose to have second-trimester invasive testing for a prenatal genetic diagnosis on the fetus. Being HIV-positive can complicate the decision-making process.
  
  
  OBJECTIVE
  To document HIV status and prenatal genetic diagnosis choices in women of AMA attending genetic clinics in Johannesburg, South Africa, for counselling on the risks of abnormalities in their fetuses.
  
  
  METHODS
  Data on the characteristics of the sample, HIV status and prenatal diagnosis decisions were collected retrospectively from the files of 350 women (>34 years) counselled for AMA in genetic clinics in Johannesburg and Pretoria. The time period was 6 months in 2003 and 6 months in 2004. A sample of the women (n=15) who were HIV-positive were interviewed and completed questionnaires on their understanding of their situation. The data were analysed and submitted to statistical testing.
  
  
  RESULTS
  Of the 350 women, 183 (52.3%) were HIV-negative, 44 (12.6%) HIV-positive, and 123 (35.1%) of unknown status. Significantly more HIV-negative patients (79/183, 43.2%) than those who were HIV-positive (6/44, 13.6%) had amniocentesis performed for fetal diagnosis. Most of the interviewed women (12/15, 80.0%) understood the severity of HIV infection, 5 (33.3%) considered termination of pregnancy based on the transmission risk, and 4 (26.7%) would have requested amniocentesis and prenatal diagnosis if they had been HIV-negative. CONCLUSION. Decision-making regarding prenatal genetic diagnosis is influenced by HIV status among older women. Effective access to highly active antiretroviral therapy throughout pregnancy would make decision-making easier for these women.
authors.affiliation: Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa. js.oellermann@gmail.com.
authors.forename: Justine S
authors.initials: JS
authors.lastname: Bee
authors.forename: Merlyn
authors.initials: M
authors.lastname: Glass
authors.forename: Jennifer G R
authors.initials: JG
authors.lastname: Kromberg
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Christianson
mesh_terms: D002755:Choice Behavior; D002869:Chromosome Aberrations; D005260:Female; D005817:Genetic Counseling; D015658:HIV Infections; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011296:Prenatal Diagnosis; D018570:Risk Assessment