title: Biodistribution of rhenium cluster complex K₄[Re6S8(CN)6] in the body of laboratory rats.
abstract: We studied the biodistribution of luminescent octahedral rhenium cluster complex K4[Re6S8(CN)6], a promising agent for photodynamic therapy. It was shown that rhenium complex [Re6S8(CN)6](4-)is mainly accumulated in the liver, the central organ of metabolism, and can be excreted by the kidneys. The cluster complex was also accumulated in the spleen in significant amount, which makes it a promising agent for creation of preparations for diagnostics and treatment of lymphoproliferative disorders. The mean lethal dose of the cluster complex was 0.38 g/kg.
authors.affiliation: A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences; Innovation Center Vektor, Novosibirsk; Novosibirsk State National Research University, Russia; Soochow University, Waishuanghsi, Shihlin, Taipei, Taiwan. fed@niic.nsc.ru.
authors.forename: K A
authors.initials: KA
authors.lastname: Brylev
authors.forename: M A
authors.initials: MA
authors.lastname: Shestopalov
authors.forename: O P
authors.initials: OP
authors.lastname: Khripko
authors.forename: V A
authors.initials: VA
authors.lastname: Trunova
authors.forename: V V
authors.initials: VV
authors.lastname: Zvereva
authors.forename: C C
authors.initials: CC
authors.lastname: Wang
authors.forename: Yu V
authors.initials: YV
authors.lastname: Mironov
authors.forename: V E
authors.initials: VE
authors.lastname: Fedorov
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000493:pharmacokinetics* / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D007928:Lethal Dose 50; D008099:Liver / Q000378:metabolism; D020714:Maximum Tolerated Dose; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D056831:Coordination Complexes; D017319:Photosensitizing Agents