title: Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells.
abstract: Helicobacter pylori infections can induce pathologies ranging from chronic gastritis, peptic ulceration to gastric cancer. Bacterial isolates harbor numerous well-known adhesins, vacuolating cytotoxin VacA, protease HtrA, urease, peptidoglycan, and type IV secretion systems (T4SS). It appears that H. pylori targets more than 40 known host protein receptors on epithelial or immune cells. A series of T4SS components such as CagL, CagI, CagY, and CagA can bind to the integrin α 5β 1 receptor. Other targeted membrane-based receptors include the integrins αvβ 3, αvβ 5, and β 2 (CD18), RPTP-α/β, GP130, E-cadherin, fibronectin, laminin, CD46, CD74, ICAM1/LFA1, T-cell receptor, Toll-like receptors, and receptor tyrosine kinases EGFR, ErbB2, ErbB3, and c-Met. In addition, H. pylori is able to activate the intracellular receptors NOD1, NOD2, and NLRP3 with important roles in innate immunity. Here we review the interplay of various bacterial factors with host protein receptors. The contribution of these interactions to signal transduction and pathogenesis is discussed.
authors.affiliation: Friedrich Alexander University Erlangen-Nuremberg; Department of Biology, Chair of Microbiology; Erlangen, Germany.
authors.forename: Suneesh Kumar
authors.initials: SK
authors.lastname: Pachathundikandi
authors.affiliation: Friedrich Alexander University Erlangen-Nuremberg; Department of Biology, Chair of Microbiology; Erlangen, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Tegtmeyer
authors.affiliation: Friedrich Alexander University Erlangen-Nuremberg; Department of Biology, Chair of Microbiology; Erlangen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Backert
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D058947:Bacterial Secretion Systems; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D011956:Receptors, Cell Surface
keywords: E-cadherin; EGF receptor; c-Met; integrins; molecular pathogenesis; virulence