title: The role of the brain-derived neurotrophic factor SNP rs2883187 in the phenotypic expression of obsessive-compulsive disorder.
abstract: We investigated the association between a brain-derived neurotrophic factor (BDNF) gene polymorphism and clinical features in a sample of patients with obsessive-compulsive disorder (OCD). A total of 100 patients diagnosed with OCD according to the Diagnostic and Statistical Manual IV criteria and 110 control subjects were included in this study. The distribution of a single nucleotide polymorphism rs2883187 was compared in OCD patients and normal controls. Clinical features were compared between the subgroups of OCD patients with different genotypes. There was no significant difference for the allele frequencies and genotype distributions between the OCD and control groups. The Hamilton Anxiety Rating Scale, Yale-Brown Obsessive Compulsive Scale obsession and total scores were found to be higher in patients with the CC genotype than in the patients who are homozygous for the T allele. The rates of OCD in first-degree relatives of OCD patients who were homozygous for the C allele were significantly higher, compared to those with CT and TT genotypes. Our results indicate that the CC genotype may be associated with the severity and increased familial loading of OCD. Further investigation based on larger populations is needed to reveal the full association of the BDNF polymorphism with OCD.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. Electronic address: rtukel@gmail.com.
authors.forename: Raşit
authors.initials: R
authors.lastname: Tükel
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Ozata
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey.
authors.forename: Nalan
authors.initials: N
authors.lastname: Oztürk
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey.
authors.forename: Banu Aslantaş
authors.initials: BA
authors.lastname: Ertekin
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Ertekin
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey.
authors.forename: Güher Saruhan
authors.initials: GS
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Obsessive-compulsive disorder; SNP; rs2883187