title: Respiratory toxicity of repeated exposure to particles produced by traffic and sugar cane burning.
abstract: We compared the toxicity of subchronic exposure to equivalent masses of particles from sugar cane burning and traffic. BALB/c mice received 3 intranasal instillations/week during 1, 2 or 4 weeks of either distilled water (C1, C2, C4) or particles (15μg) from traffic (UP1, UP2, UP4) or biomass burning (BP1, BP2, BP4). Lung mechanics, histology and oxidative stress were analyzed 24h after the last instillation. In all instances UP and BP groups presented worse pulmonary elastance, airway and tissue resistance, alveolar collapse, bronchoconstriction and macrophage influx into the lungs than controls. UP4, BP2 and BP4 presented more alveolar collapse than UP1 and BP1, respectively. UP and BP had worse bronchial and alveolar lesion scores than their controls; BP4 had greater bronchial lesion scores than UP4. Catalase was higher in UP4 and BP4 than in C4. In conclusion, biomass particles were more toxic than those from traffic after repeated exposures.
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Universidade Federal do Rio de Janeiro, São Paulo, Brazil.
authors.forename: Flavia
authors.initials: F
authors.lastname: Mazzoli-Rocha
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Universidade Federal do Rio de Janeiro, São Paulo, Brazil.
authors.forename: Giovanna M C
authors.initials: GM
authors.lastname: Carvalho
authors.affiliation: Laboratory of Inflammation, Fundação Oswaldo Cruz, São Paulo, Brazil.
authors.forename: Manuella
authors.initials: M
authors.lastname: Lanzetti
authors.affiliation: Laboratory of Inflammation, Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, São Paulo, Brazil.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Valença
authors.affiliation: Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Luiz F F
authors.initials: LF
authors.lastname: Silva
authors.affiliation: Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Paulo H N
authors.initials: PH
authors.lastname: Saldiva
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Universidade Federal do Rio de Janeiro, São Paulo, Brazil. Electronic address: wazin@biof.ufrj.br.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Zin
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Universidade Federal do Rio de Janeiro, São Paulo, Brazil.
authors.forename: Débora S
authors.initials: DS
authors.lastname: Faffe
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001980:Bronchi / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid; D002374:Catalase / Q000378:metabolism; D005260:Female; D037502:Galectin 3 / Q000378:metabolism; D019570:Inhalation Exposure; D008168:Lung / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D012120:Respiration Disorders / Q000139:chemically induced*; D031786:Saccharum / Q000737:chemistry*; D018709:Statistics, Nonparametric; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D037502:Galectin 3; D052638:Particulate Matter; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase
keywords: Air pollution; Lung mechanics; Oxidative stress; Particulate matter; Sugar cane burning