title: Cost-effectiveness of one year dementia follow-up care by memory clinics or general practitioners: economic evaluation of a randomised controlled trial.
abstract: OBJECTIVE
  To evaluate the cost-effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared to general practitioners' care.
  
  
  METHODS
  A multicentre randomised trial with 175 community dwelling patients newly diagnosed with mild to moderate dementia, and their informal caregivers, with twelve months' follow-up. Cost-effectiveness was evaluated from a societal point of view and presented as incremental cost per quality adjusted life year. To establish cost-effectiveness, a cost-utility analysis was conducted using utilities based on the EQ-5D. Uncertainty surrounding the incremental cost-effectiveness ratio (difference in costs divided by difference in effects) was calculated by bootstrapping from the original data.
  
  
  RESULTS
  Compared to general practitioners' care, treatment by the memory clinics was on average €1024 (95% CI: -€7723 to €5674) cheaper, and showed a non-significant decrease of 0.025 (95% CI: -0.114 to 0.064) quality adjusted life years. The incremental cost-effectiveness point estimate from the bootstrap simulation was € 41 442 per QALY lost if one would use memory clinic care instead of general practitioner care.
  
  
  CONCLUSIONS
  No evidence was found that memory clinics were more cost-effective compared to general practitioners with regard to post-diagnosis treatment and coordination of care of patients with dementia in the first year after diagnosis.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00554047.
authors.affiliation: Department of Geriatrics/Radboud Alzheimer Centre, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Els
authors.initials: E
authors.lastname: Meeuwsen
authors.forename: René
authors.initials: R
authors.lastname: Melis
authors.forename: Geert
authors.initials: G
authors.lastname: van der Aa
authors.forename: Gertie
authors.initials: G
authors.lastname: Golüke-Willemse
authors.forename: Benoit
authors.initials: B
authors.lastname: de Leest
authors.forename: Frank
authors.initials: F
authors.lastname: van Raak
authors.forename: Carla
authors.initials: C
authors.lastname: Schölzel-Dorenbos
authors.forename: Desiree
authors.initials: D
authors.lastname: Verheijen
authors.forename: Frans
authors.initials: F
authors.lastname: Verhey
authors.forename: Marieke
authors.initials: M
authors.lastname: Visser
authors.forename: Claire
authors.initials: C
authors.lastname: Wolfs
authors.forename: Eddy
authors.initials: E
authors.lastname: Adang
authors.forename: Marcel
authors.initials: M
authors.lastname: Olde Rikkert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities; D017028:Caregivers; D003362:Cost-Benefit Analysis; D003704:Dementia / Q000191:economics / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D058005:General Practitioners; D006801:Humans; D008297:Male; D008568:Memory; D011788:Quality of Life; D019057:Quality-Adjusted Life Years