title: Impacts of the apoptosis inhibitor of macrophage (AIM) on obesity-associated inflammatory diseases.
abstract: Obesity is associated with various metabolic and cardiovascular diseases caused by chronic, low-grade inflammation that is initially observed in obese adipose tissue. In addition, many etiological studies in humans have shown a strong correlation between obesity and inflammatory autoimmune diseases. In this review, we focus on the involvement of apoptosis inhibitor of macrophage (AIM), a macrophage-derived blood protein, in both types of immune response. Through differential mechanisms, AIM thereby plays key roles in the pathogenesis of atherosclerosis, metabolic diseases, and obesity-associated autoimmune diseases. Thus, the regulation of blood AIM levels or AIM function has the potential to serve as a next-generation therapy against these inflammatory diseases brought about by modern lifestyle.
authors.affiliation: Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan, sarai@m.u-tokyo.ac.jp.
authors.forename: Satoko
authors.initials: S
authors.lastname: Arai
authors.forename: Toru
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D004198:Disease Susceptibility / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000209:etiology*; D051034:Inhibitor of Apoptosis Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D007333:Insulin Resistance; D008066:Lipolysis / Q000235:genetics; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D051034:Inhibitor of Apoptosis Proteins; D047495:PPAR gamma; D011961:Receptors, Fc; D051197:Toll-Like Receptor 4