title: Chemoselective N-deacetylation under mild conditions.
abstract: A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.
authors.affiliation: Mendeleev Block, Department of Chemistry, Indian Institute of Science Education & Research (IISER), Pune, 411008, Maharashtra, India. rgb@iiserpune.ac.in.
authors.forename: Prakash R
authors.initials: PR
authors.lastname: Sultane
authors.forename: Trimbak B
authors.initials: TB
authors.lastname: Mete
authors.forename: Ramakrishna G
authors.initials: RG
authors.lastname: Bhat
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000107:Acetylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013696:Temperature; D013997:Time Factors
chemical_list: D000081:Acetamides; D000588:Amines