title: Dibenzoyl and isoflavonoid glycosides from Sophora flavescens: inhibition of the cytotoxic effect of D-galactosamine on human hepatocyte HL-7702.
abstract: Twelve new dibenzoyl derivatives sophodibenzoside A-L (1-12) and five new isoflavone glycosides (13-17) have been isolated from the roots of Sophora flavescens together with eight known compounds (18-25). Notably, the use of acetic acid-d4 was required to enable identification of the dibenzoyl glycoside structures. Compounds 1, 2, 13, 14, and 19 exhibited weak inhibition of the cytotoxic effect of d-galactosamine on the human hepatic cell line HL-7702.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*
chemical_list: D001565:Benzoates; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D005688:Galactosamine; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D019342:Acetic Acid