title: The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity.
abstract: Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1-3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.
authors.affiliation: School of Chemical Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia. ohasnah@usm.my.
authors.forename: Noviany
authors.initials: N
authors.lastname: Hasan
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.forename: Suriyati
authors.initials: S
authors.lastname: Mohamad
authors.forename: Wong Keng
authors.initials: WK
authors.lastname: Chong
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Anis Safirah Mohd
authors.initials: AS
authors.lastname: Zahariluddin