title: Catalytic antioxidants: regenerable tellurium analogues of vitamin E.
abstract: In an effort to improve the chain-breaking capacity of the natural antioxidants, an octyltelluro group was introduced next to the phenolic moiety in β- and δ-tocopherol. The new vitamin E analogues quenched peroxyl radicals more efficiently than α-tocopherol and were readily regenerable by aqueous N-acetylcysteine in a simple membrane model composed of a stirring chlorobenzene/water two-phase system. The novel tocopherol analogues could also mimic the action of the glutathione peroxidase enzymes.
authors.affiliation: Uppsala University , Department of Chemistry - BMC, Box 576, SE-751 23 Uppsala, Sweden.
authors.forename: Vijay P
authors.initials: VP
authors.lastname: Singh
authors.forename: Jia-fei
authors.initials: JF
authors.lastname: Poon
authors.forename: Lars
authors.initials: L
authors.lastname: Engman
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013691:Tellurium / Q000737:chemistry*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D013691:Tellurium