title: Treatment of erectile dysfunction: new targets and strategies from recent research.
abstract: In recent years, research on penile erection has increasingly been centered on the molecular mechanisms involved. Major progress has been made in the field and at present a whole number of neurotransmitters, chemical effectors, growth factors, second-messenger molecules, ions, intercellular proteins, and hormones have been characterized as components of the complex process of erection. This knowledge has led to the discovery of several new therapeutic targets and multiple medical approaches for the treatment of erectile dysfunction (ED). This review focuses on the progress made in this field within the last few years.
authors.affiliation: Department of Pharmacology, Ghent University, Ghent, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Decaluwé
authors.affiliation: Department of Pharmacology, Ghent University, Ghent, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Pauwels
authors.affiliation: Department of Pharmacology, Ghent University, Ghent, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Boydens
authors.affiliation: Department of Pharmacology, Ghent University, Ghent, Belgium. Electronic address: johan.vandevoorde@UGent.be.
authors.forename: J
authors.initials: J
authors.lastname: Van de Voorde
mesh_terms: D000529:Complementary Therapies; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D007172:Erectile Dysfunction / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology; D011945:Receptors, Angiotensin / Q000502:physiology; D017466:Receptors, Endothelin / Q000502:physiology; D044968:Regenerative Medicine; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D023822:Tissue Engineering; D014579:Urotensins / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000502:physiology
chemical_list: D011941:Receptors, Adrenergic; D011945:Receptors, Angiotensin; D017466:Receptors, Endothelin; D014579:Urotensins; C066737:RHOA protein, human; D009569:Nitric Oxide; C029677:urotensin II; D000242:Cyclic AMP; D020742:rhoA GTP-Binding Protein; D006152:Cyclic GMP; D006862:Hydrogen Sulfide
keywords: Corpora cavernosa; Cyclic GMP; Erectile dysfunction; Innovative therapies; Nitric oxide