title: Synchronous occurrence of nasopharyngeal carcinoma and Hodgkin lymphoma.
abstract: Latent Epstein-Barr virus infection is associated with several lymphoid and epithelial malignancies. This is the first reported case of a patient presenting with synchronous nasopharyngeal carcinoma and Hodgkin lymphoma associated with Epstein-Barr virus. A 17-year-old previously healthy African-American male presented with anterior mediastinal mass and a nasopharyngeal mass. Histology from biopsy of both lesions revealed evidence of Epstein-Barr virus. The patient successfully completed sequential therapies with chemo radiation with no evidence of active disease. Simultaneous occurrence of the two malignancies is undoubtedly a rare event, and their coexistence raises the question of a common etiologic factor.
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA.
authors.forename: Janalee
authors.initials: J
authors.lastname: Stokken
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Manz
authors.affiliation: Cleveland Clinic, Department of Pediatric Hematology and Oncology, Cleveland, OH, USA.
authors.forename: Aron
authors.initials: A
authors.lastname: Flagg
authors.affiliation: Cleveland Clinic, Department of Pediatric Hematology and Oncology, Cleveland, OH, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kate Gowans
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA. Electronic address: annes@ccf.org.
authors.forename: Samantha
authors.initials: S
authors.lastname: Anne
mesh_terms: D000293:Adolescent; D002277:Carcinoma; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000628:therapy; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000473:pathology* / Q000628:therapy / Q000821:virology; D006801:Humans; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy / Q000821:virology; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery / Q000821:virology; D016133:Polymerase Chain Reaction; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
keywords: Epstein–Barr virus; Hodgkin lymphoma; Nasopharyngeal carcinoma; Viral oncogenesis