title: Spectral detection of sickle cell anemia and thalassemia.
abstract: Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common techniques for detection of these diseases are complete blood cell count, followed by electrophoresis and high performance liquid chromatography. In this connection, the results of this paper indicate the potential of a new technique, based on spectral analysis of blood plasma and cellular components, to detect SCD and Thal with accuracy of 90% and above. To the best of our knowledge this would be the first report on spectral pathology of hemoglobinopathy.
authors.affiliation: Department of Physics and Astronomy, King Saud University, KSA. Electronic address: masila123@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Masilamani
authors.forename: M S
authors.initials: MS
authors.lastname: Al Salhi
authors.forename: S
authors.initials: S
authors.lastname: Devanesan
authors.forename: Farjah H
authors.initials: FH
authors.lastname: Algahtani
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Abu-Salah
authors.forename: I
authors.initials: I
authors.lastname: Ahamad
authors.forename: P
authors.initials: P
authors.lastname: Agastian
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000175:diagnosis*; D001663:Bilirubin / Q000097:blood*; D001664:Biliverdine / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D011166:Porphyrins / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013789:Thalassemia / Q000097:blood / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011166:Porphyrins; D001664:Biliverdine; D001663:Bilirubin
keywords: Fluorescence spectra; Photo diagnosis; Sickle cell disease and thalassemia; Synchronous fluorescence