title: Bee venom ameliorates compound 48/80-induced atopic dermatitis-related symptoms.
abstract: Honeybee (Apis mellifera L.) venom (BV) has been traditionally used for the treatment of pain and inflammatory diseases such as itchy skin problems. However, the precise mechanism of BV in ameliorating the scratching behavior is not fully understood.
  
  
  OBJECTIVE
  In order to evaluate the effect of BV on atopic dermatitis-related symptoms in mice, we used a mouse skin scratching model induced by compound 48/80. The anti-itch effect of BV was investigated in a compound 48/80-induced mouse scratching behavior model. BALB/c mice were injected intraperitoneally with vehicle (saline 0.9%) or BV (0.01 and 0.1 mg/kg). One hour after treatment, the animals received a subcutaneous injection of compound 48/80. Intraperitoneal administration of BV (0.01 and 0.1 mg/kg) attenuated compound 48/80-induced scratching behaviors. The anti-scratching behavior effect of BV was in proportional to its vascular permeability effects. Treatment with BV also inhibited the degranulation of mast cells and the production of pro-inflammatory cytokines in compound 48/80-treated skin tissues. According to these results, BV may improve atopic dermatitis-related symptoms by inhibiting the mast cell degranulation and pro-inflammatory cytokine expression.
authors.affiliation: Department of Pathology, Catholic University of Daegu, College of Medicine Daegu, 705-718, Republic of Korea.
authors.forename: Kyung-Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Woo-Ram
authors.initials: WR
authors.lastname: Lee
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: An
authors.forename: Jung-Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyun
authors.initials: H
authors.lastname: Chung
authors.forename: Sang-Mi
authors.initials: SM
authors.lastname: Han
authors.forename: Myeong-Lyoel
authors.initials: ML
authors.lastname: Lee
authors.forename: Kwang-Gill
authors.initials: KG
authors.lastname: Lee
authors.forename: Sok Cheon
authors.initials: SC
authors.lastname: Pak
authors.forename: Kwan-Kyu
authors.initials: KK
authors.lastname: Park
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000982:Antipruritics / Q000008:administration & dosage / Q000494:pharmacology*; D001514:Bee Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D015550:Cell Degranulation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D000893:Anti-Inflammatory Agents; D000982:Antipruritics; D001514:Bee Venoms; D016207:Cytokines; D018836:Inflammation Mediators; D003189:p-Methoxy-N-methylphenethylamine
keywords: Bee venom; compound 48/80; inflammation; mast cell degranulation; scratching behavior