title: Poly-combing the genome for RNA.
abstract: An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.
authors.affiliation: Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, Massachusetts, USA, and the Broad Institute, Cambridge, Massachusetts, USA.
authors.forename: Loyal A
authors.initials: LA
authors.lastname: Goff
authors.forename: John L
authors.initials: JL
authors.lastname: Rinn
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism*; D006801:Humans; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D063151:Polycomb Repressive Complex 2