title: Are immunoconjugates approaching "standard of care" in AML?
abstract: It seems clear that immunoconjugates, the combinations of antibodies with toxins, will play a role in therapy of acute myeloid leukemia (AML). It is also clear that sole emphasis on an average trial result is misplaced in AML, as the example of gentuzumab ozogamicin illustrates. Gemtuzumab added to chemotherapy can improve survival in many patients with newly diagnosed disease. The future of immunoconjugates, however, may rest on further defining the relation between CD33 and the AML stem cell and its importance in therapy. Three immunoconjugates with the cell surface antigens CD33, CD45, and CD30 will be reviewed here.
authors.affiliation: University of Washington and Fred Hutchinson Cancer Research Center, 825 Eastlake Ave E, Mailstop G3-200, Seattle, WA 98109, USA. Electronic address: eestey@uw.edu.
authors.forename: Elihu
authors.initials: E
authors.lastname: Estey
mesh_terms: D000368:Aged; D000617:Aminoglycosides / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000079982:Gemtuzumab; D015870:Gene Expression; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D008875:Middle Aged; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D059039:Standard of Care; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D000617:Aminoglycosides; D061067:Antibodies, Monoclonal, Humanized; D015703:Antigens, CD; D000970:Antineoplastic Agents; D018796:Immunoconjugates; D000079982:Gemtuzumab
keywords: (225)Actinium; AML; APL; CD30; CD33; CD45; SGN-CD331; acute myeloid leukemia; acute promyelocytic leukemia; antibody; antigen; brentuximab; gentuzumab ozogamicin; immunoconjugates