title: Low high-density lipoprotein cholesterol is characterized by elevated oxidative stress.
abstract: High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for premature atherosclerosis and cardiovascular disease. Plasma HDL exerts potent antioxidant activity. We evaluated parameters associated with oxidative stress in participants with low HDL-C. This study included 32 patients with low HDL-C (≤35 mg/dL) and 33 age- and sex-matched control patients with normal HDL-C (>35 mg/dL). We evaluated clinical and laboratory parameters that are associated with oxidative stress. The oxidative stress index (OSI) levels were significantly higher in the low HDL-C group (3.32 [0.01-13.3] vs 0.74 [0.17-3.55] AU; P<.01) and negatively correlated with HDL-C levels. We suggest that change in OSI and uric acid levels in the study group might indicate increased oxidative status in patients with low HDL-C. This may be associated with increased cardiovascular risk.
authors.affiliation: Department of Cardiology, Isparta State Hospital, Isparta, Turkey drmustafa1979@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.affiliation: Department of Cardiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.affiliation: Department of Cardiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kahraman
authors.affiliation: Department of Cardiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozaydin
authors.affiliation: Department of Emergency Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Ahmet Kenan
authors.initials: AK
authors.lastname: Türkdogan
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Isparta State Hospital, Isparta, Turkey.
authors.forename: Ismail Hakkı
authors.initials: IH
authors.lastname: Ersoy
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014527:Uric Acid
keywords: high-density lipoprotein; oxidative stress; oxidative stress index