title: Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle.
abstract: Three new glycosides: thotneoside A (quercetin 3-O-(6″-O-phenylacetyl)-β-D-galactopyranoside) (1), thotneoside B (quercetin 3-O-(6″-O-phenylacetyl)-β-D-glucopyranoside) (2) and thotneoside C (3-methyl-2-butenoic acid 1-O-β-D-glucopyranoside) (3), together with nine known compounds; quercetin (4), quercetin 3-O-β-D-galactopyranoside (5), quercetin 3-O-(6″-O-galloyl)-β-D-galactopyranoside (6), quercetin 3-O-β-D-galacturonopyranoside (7), quercetin 3-O-β-D-glucuronopyranoside (8), quercetin 3-O-α-L-rhamnopyranoside (9), rutin (10), quercetin 3-O-α-L-arabinopyranoside (11) and 2,4,6-trihydroxyacetophenone 2-O-β-D-glucopyranoside (12) have been isolated from the shade dried leaves of Aconogonon molle, commonly known as "Thotne″ in Nepal. The structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from A. molle and their in vitro antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Quercetin (4) and its glycosides (1-2, 5-11) showed potent free radical scavenging activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University.
authors.forename: Khem Raj
authors.initials: KR
authors.lastname: Joshi
authors.forename: Hari Prasad
authors.initials: HP
authors.lastname: Devkota
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Shoji
authors.initials: S
authors.lastname: Yahara
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D019664:Polygonaceae / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D006027:Glycosides; D010851:Picrates; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl