title: Cardiovascular events in acromegaly: distinct role of Agatston and Framingham score in the 5-year prediction.
abstract: Prediction of ischemic cardiovascular events (ICE) in acromegalic patients stratified accordingly with Framingham (FS) and Agatston score (AS). 32 patients with active (group A (0)) and 20 with controlled (group B (0)) acromegaly have been enrolled. During the 5-year follow-up, 19 out of 32 patients in group A (0) reached disease control. At entry, FS and AS, by an eight-slice MDCT scanner, were calculated in all patients. ICE were diagnosed by autopsy, if lethal, and by electrocardiography and/or echocardiography, if non-lethal. Overall, 9.6 % of patients died for lethal ICE. AS >400, but not high FS at entry, was associated with increased risk of lethal ICE. Lethal ICE had occurred in two patients of group A (0) and three of group B (0) (p NS), while a non-lethal ICE had occurred in two cases of the former and in other two of the latter group (p NS). Either FS or AS was correlated with the risk for ICE overall (p < 0.02), but only AS correlated with that of lethal ICE (p < 0.0003). Survival analysis demonstrated reduced life expectancy in patients with high FS (p < 0.02). In acromegalics, AS >400 is associated with increased risk of lethal ICE, while high FS is associated with reduced life expectancy, regardless of disease control.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy, ragonese_m@yahoo.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Ragonese
authors.forename: Angela
authors.initials: A
authors.lastname: Alibrandi
authors.forename: Gianluca
authors.initials: G
authors.lastname: Di Bella
authors.forename: Ignazio
authors.initials: I
authors.lastname: Salamone
authors.forename: Soraya
authors.initials: S
authors.lastname: Puglisi
authors.forename: Oana Ruxandra
authors.initials: OR
authors.lastname: Cotta
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Torre
authors.forename: Francesco
authors.initials: F
authors.lastname: Ferrau
authors.forename: Rosaria Maddalena
authors.initials: RM
authors.lastname: Ruggeri
authors.forename: Francesco
authors.initials: F
authors.lastname: Trimarchi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cannavo
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000453:epidemiology*; D000236:Adenoma / Q000150:complications / Q000453:epidemiology; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000453:epidemiology; D011379:Prognosis; D012107:Research Design; D012307:Risk Factors; D055815:Young Adult