title: Catalyst assisted synthesis of initiator attached silica monolith particles via isocyanate-hydroxyl reaction for production of polystyrene bound chromatographic stationary phase of excellent separation efficiency.
abstract: Dibutyltin dichloride (DBTDC) was used as a catalyst to chemically bind 4-chloromehtylphenylisocynate (4-CPI) to porous monolithic silica particles via isocyanate-hydroxyl reaction, and the reaction product was reacted with sodium diethyldithiocarbamate (SDDC) to yield initiator attached silica monolith particles. Reversible addition-fragmentation transfer (RAFT) polymerization was taken place on them to result in polystyrene attached silica particles that showed excellent separation efficiency when packed in a chromatographic column (1.0 mm × 300 mm). The numbers of theoretical plates (N) of 56,500 is better than those of any commercially available HPLC or UHPLC column yet.
authors.affiliation: Department of Chemistry, Inha University, 100 Inharo, Namku, Incheon 402-751, South Korea.
authors.forename: Faiz
authors.initials: F
authors.lastname: Ali
authors.affiliation: Department of Chemistry, Inha University, 100 Inharo, Namku, Incheon 402-751, South Korea.
authors.forename: Yune Sung
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Inha University, 100 Inharo, Namku, Incheon 402-751, South Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Inha University, 100 Inharo, Namku, Incheon 402-751, South Korea. Electronic address: wjcheong@inha.ac.kr.
authors.forename: Won Jo
authors.initials: WJ
authors.lastname: Cheong
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D017953:Isocyanates / Q000737:chemistry*; D008024:Ligands; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011137:Polystyrenes / Q000138:chemical synthesis*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D017953:Isocyanates; D008024:Ligands; D011137:Polystyrenes; D012822:Silicon Dioxide
keywords: Catalyzed isocyanate-hydroxyl reaction; Excellent high separation efficiency; Initiator attached silica particles; Polystyrene bonded phase; RAFT polymerization