title: Hormonal relationships to bone mass in elderly Spanish men as influenced by dietary calcium and vitamin D.
abstract: We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men. Serum PTH and 25-OH-Vitamin D3 were measured in 195 healthy elderly men (mean age: 73.31 ± 5.10 year). Food intake was quantified using a dietetic scale. Participants with 25-OH-Vitamin D3 levels ≥ 30 ng/mL (75 nmol/L) and a calcium intake of 800-1200 mg/day exhibited the lowest PTH levels (41.49 ± 16.72 ng/mL). The highest PTH levels (75.60 ± 14.16 ng/mL) were observed in the <30 ng/mL group 25-OH-Vitamin D3 with a calcium intake >1200 mg/day. No significant differences in the serum PTH levels based on the serum 25-OH-Vitamin D3 levels were observed among participants with a calcium intake of 800-1200 mg/day. Serum PTH was inversely correlated with serum 25-OH-Vitamin D3 in the entire patient sample (r = -0.288, p = 0.019). No differences in any of the three densitometry techniques were observed between any of the age groups in the 800-1200 mg/day and >1200 mg/day calcium intake groups. PTH levels correlate negatively with serum 25-OH-Vitamin D3 levels, and neither calcium nor vitamin D intake exert a strong influence on either of the two parameters.
authors.affiliation: Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy, University of Extremadura, Caceres 10003, Spain. jpedrera@unex.es.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Moran
authors.forename: Luis Gonzalez
authors.initials: LG
authors.lastname: Lopez-Arza
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Lavado-Garcia
authors.forename: Maria
authors.initials: M
authors.lastname: Pedrera-Canal
authors.forename: Purificacion
authors.initials: P
authors.lastname: Rey-Sanchez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Rodriguez-Velasco
authors.forename: Pilar
authors.initials: P
authors.lastname: Fernandez
authors.forename: Juan D
authors.initials: JD
authors.lastname: Pedrera-Zamorano
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D016014:Linear Models; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D010865:Pilot Projects; D012424:Rural Population; D013030:Spain; D014463:Ultrasonography; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood
chemical_list: D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D014807:Vitamin D