title: The molecular basis of mutagenesis - 40 years of research on genomic integrity.
abstract: This article reviews the multiple mechanisms by which both prokaryotes and eukaryotes remove or tolerate various types of naturally occurring and exogenously generated base damage in DNA.
authors.affiliation: Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. errol.friedberg@utsouthwestern.edu.
authors.forename: Errol C
authors.initials: EC
authors.lastname: Friedberg
mesh_terms: D001435:Bacteriophages / Q000502:physiology; D004249:DNA Damage / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D056890:Eukaryota / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D016296:Mutagenesis / Q000235:genetics*; D011387:Prokaryotic Cells / Q000502:physiology; D014983:Xeroderma Pigmentosum; D000099270:Y-Family DNA Polymerases
chemical_list: D004259:DNA-Directed DNA Polymerase; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases