title: Combinatorial synthesis of oxazol-thiazole bis-heterocyclic compounds.
abstract: A combinatorial library of novel oxazol-thiazole bis-heterocycles was synthesized in good to excellent overall yields with high purity using a solution and solid-phase parallel synthesis approach. Oxazole amino acids, prepared from serine methyl ester and amino acids via coupling and cyclodehydration, were treated with Fmoc-NCS and α-haloketones for the parallel synthesis of diverse bis-heterocycles. Fmoc-isothiocyanate is used as a traceless reagent for thiazole formation. Oxazole diversity can be achieved by using variety of amino acids, whereas thiazole diversity is produced with various haloketones.
authors.affiliation: Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St Lucie, Florida 34987, United States.
authors.forename: Siva
authors.initials: S
authors.lastname: Murru
authors.forename: Adel
authors.initials: A
authors.lastname: Nefzi
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D010080:Oxazoles; D013844:Thiazoles