title: Novel therapies for treating familial hypercholesterolemia.
abstract: Familial hypercholesterolemia is an inherited disorder associated with early accelerated atherosclerosis with morbidity and mortality resulting from premature cardiovascular disease. Affected individuals have extreme elevations in low-density lipoprotein cholesterol levels. Patients usually do not achieve target reductions in cholesterol levels with conventional antihyperlipidemic pharmacotherapy. This unmet need has resulted in the recent development and approval of novel therapies targeting different cholesterol pathways. This article briefly summarizes familial hypercholesterolemia and then discusses the newer pharmacotherapies available in the management of familial hypercholesterolemia.
authors.affiliation: Section of Cardiology, Department of Medicine, Texas Heart Institute, St. Luke's Episcopal Hospital, 6720 Bertner, MC 1-133, Houston, TX, 77030, USA, salmanbandeali@hotmail.com.
authors.forename: Salman J
authors.initials: SJ
authors.lastname: Bandeali
authors.forename: Jad
authors.initials: J
authors.lastname: Daye
authors.forename: Salim S
authors.initials: SS
authors.lastname: Virani
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D008078:Cholesterol, LDL / Q000378:metabolism; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000188:drug therapy*; D009841:Oligonucleotides / Q000627:therapeutic use
chemical_list: D000924:Anticholesteremic Agents; C473731:BMS201038; D001562:Benzimidazoles; D008078:Cholesterol, LDL; D009841:Oligonucleotides; C524142:mipomersen