title: Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat.
abstract: OBJECTIVE
  The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity.
  
  
  METHODS
  THE ANIMALS WERE DIVIDED INTO THREE GROUPS: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternative days), and group C further to cisplatin received the aqueous extract of Rheum ribes (150 mg/rat).
  
  
  RESULTS
  Blood urea nitrogen (BUN) level increased in group B on days 14 and 42 compared to day 0 (P < 0.001); it was also increased in group B vs. group A on day 14 (P < 0.001). Rheum ribes extract decreased the serum BUN level on day 14 compared to group B (P < 0.001). Serum creatinine level in group B had a similar profile as serum BUN level but Rheum ribes had no effect on blood creatinine level. Serum cholesterol level was increased in group B on days 14 and 42 compared to day 0 (P < 0.001). Also, cholesterol level was significantly increased in group B when compared to group A on day 14 (P < 0.001). Rheum ribes decreased the blood cholesterol level on day 42 in comparison to group B (P < 0.001). Serum glucose level was increased in group B on days 14 and 42 vs. day 0 (P < 0.001). Also, glucose level was significantly increased in group B when compared to group A on day 42 (P < 0.001). Rheum ribes increased the serum glucose level on days 14 and 42 compared to day 0 (P < 0.05). Histology of kidneys exposed to cisplatin showed renal injury, but Rheum ribes had no effect on the kidney architecture.
  
  
  CONCLUSIONS
  Cisplatin-induced nephrotoxicity was confirmed in our study. Although Rheum ribes had some effects on biochemical parameters; its effect on renal histology in injured kidney was insignificant.
authors.affiliation: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; Neuroscience Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mousa-Al-Reza
authors.initials: MA
authors.lastname: Hadjzadeh
authors.forename: Ziba
authors.initials: Z
authors.lastname: Rajaei
authors.forename: Zakieh
authors.initials: Z
authors.lastname: Keshavarzi
authors.forename: Mohsen Ghasem
authors.initials: MG
authors.lastname: Shirazi
authors.forename: Vahedeh
authors.initials: V
authors.lastname: Toosi
keywords: Blood urea nitrogen; Rheum ribes; cholesterol; cisplatin; creatinine