title: Macular thickness after glaucoma filtration surgery.
abstract: The aim of present study was to analyze early postoperative changes in the macular area using optical coherence tomography (OCT) after uncomplicated glaucoma filtration surgery. This prospective study included 32 patients (34 eyes) with open-angle glaucoma, which underwent trabeculectomy with or without use of mitomycin C. Exclusion criteria were macular edema, uveitis, age-related macular degeneration, blurred optical media, secondary glaucoma and angle-closure glaucoma. All standard clinical examinations were made before surgery, at the 2nd day, 1 week and 1 month after surgery. Tomography of the macula was performed during every examination using Cirrus HD OCT for the analysis of central subfield thickness. Results show that thickening of the macula was slightly higher 1 week and 1 month after operation in comparison with baseline end 2nd day postoperativelly. There was no significant difference in the change of macular thickness in patients who have used topical prostaglandins compared with those who have used other topical medications. Also, there was no difference in macular changes between patients treated with or without mitomycin C. In conclusion, we found a slight subclinical increase in macular thickness after uncomplicated trabeculectomy, for which we considered that was the result in reduction of intraocular pressure after glaucoma surgery. Macular thickening after glaucoma filtering surgery could be a physiological reaction to the stress of the retina caused by a sudden reduction of intraocular pressure and it is the consequence of altered relationship between capillary pressure and interstitial fluid pressure.
authors.affiliation: Clinical Hospital Mostar, Department of Ophthalmology, Mostar, Bosnia and Herzegovina. antoniosesar@yahoo.com
authors.forename: Antonio
authors.initials: A
authors.lastname: Sesar
authors.forename: Ivan
authors.initials: I
authors.lastname: Cavar
authors.forename: Anita Pusić
authors.initials: AP
authors.lastname: Sesar
authors.forename: Mia Zorić
authors.initials: MZ
authors.lastname: Geber
authors.forename: Irena
authors.initials: I
authors.lastname: Sesar
authors.forename: Katia Novak
authors.initials: KN
authors.lastname: Laus
authors.forename: Zoran
authors.initials: Z
authors.lastname: Vatavuk
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Mandić
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014130:Trabeculectomy / Q000009:adverse effects* / Q000379:methods