title: Everolimus for the treatment of subependymal giant cell astrocytoma probably causing seizure aggravation in a child with tuberous sclerosis complex: a case report.
abstract: We are reporting on a 13.5-year-old girl with tuberous sclerosis complex (TSC) who was treated with everolimus because of giant cell astrocytoma and bilateral angiomyolipoma. She suffered from pharmacoresistant partial epilepsy with clusters of tonic and tonic-clonic seizures. Treatment with carbamazepine and sulthiame had led to a stable situation for more than 2.5 years. The dosage of everolimus had to be increased and refractory status epilepticus followed after 12 days. In the absence of any other possible cause, we believe that the status epilepticus was provoked by everolimus. So far, only a few cases of possible seizure aggravation by everolimus have been reported. The clinical relevance of possible negative effects in epileptic patients remains unclear. Similar observations should be documented and reported.
authors.affiliation: Epilepsy Center Kork, Kehl-Kork, Germany.
authors.forename: Adelheid
authors.initials: A
authors.lastname: Wiemer-Kruel
authors.affiliation: Klinikum Stuttgart, Olgahospital, Stuttgart, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Woerle
authors.affiliation: Epilepsy Center Kork, Kehl-Kork, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Strobl
authors.affiliation: Epilepsy Center Kork, Kehl-Kork, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bast
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001254:Astrocytoma / Q000150:complications / Q000188:drug therapy; D004828:Epilepsies, Partial / Q000150:complications; D000068338:Everolimus; D005260:Female; D006801:Humans; D012640:Seizures / Q000150:complications; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D014402:Tuberous Sclerosis / Q000150:complications / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D000068338:Everolimus; D020123:Sirolimus