title: Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors.
abstract: In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells.
authors.affiliation: Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Av. Itzaes #490 x 59, Centro, C. P. 97000, Merida, Yucatan, Mexico, talavera@uady.mx.
authors.forename: G
authors.initials: G
authors.lastname: Ayora-Talavera
authors.forename: L
authors.initials: L
authors.lastname: Cetina-Montejo
authors.forename: A
authors.initials: A
authors.lastname: Matos-Patrón
authors.forename: L
authors.initials: L
authors.lastname: Romero-Beltrán
mesh_terms: D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006388:Hemagglutinins / Q000235:genetics / Q000378:metabolism*; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D006388:Hemagglutinins; D011956:Receptors, Cell Surface; D012794:Sialic Acids; C092488:sialic acid receptor