title: Platelet-rich plasma (PRP) in chronic epicondylitis: study protocol for a randomized controlled trial.
abstract: BACKGROUND
  Tendinopathy is a difficult problem to manage and can result in significant patient morbidity. Currently, the clinical use of platelet-rich plasma (PRP) in painful tendons is widespread but its efficacy remains controversial.
  
  
  METHODS
  This study is a single-center, randomized double-blind controlled trial. Eighty patients will be allocated to have ultrasound (US)-guided needling combined with a leukocyte-depleted (that is, pure) PRP or lidocaine each alternate week for a total of two interventions. Outcome data will be collected before intervention, and at 6 weeks, 3, 6, and 12 months after intervention.
  
  
  METHODS
  Changes in pain and activity levels, as assessed by Disabilities of the Arm, Shoulder and Hand (DASH-E, Spanish version) score, at 6 months. We will compare the percentage of patients in each group that achieve a successful treatment defined as a reduction of at least 25% in the DASH-E score. Secondary outcome measures include changes in DASH-E at 3 and 12 months, changes in pain as assessed by the visual analogue scale (VAS) at the 6-week, 3-, 6-, and 12-month follow-up, changes in sonographic features and neovascularity, and percentage of patients in each group with adverse reactions at 3, 6, and 12 months.
  
  
  CONCLUSIONS
  The results of this study will provide insights into the effect of pure PRP in tendon and may contribute to identifying the best protocol for PRP application in tendinopathies.
  
  
  BACKGROUND
  ClinicalTrials.gov: NCT01945528.
authors.affiliation: Regenerative Medicine Laboratory, BioCruces Health Research Institute, Hospital Universitario Cruces, Pza Cruces s/n, Barakaldo 48903, Spain. iandia2010@hotmail.com.
authors.forename: Jose I
authors.initials: JI
authors.lastname: Martin
authors.forename: Josu
authors.initials: J
authors.lastname: Merino
authors.forename: Leire
authors.initials: L
authors.lastname: Atilano
authors.forename: Luis M
authors.initials: LM
authors.lastname: Areizaga
authors.forename: Maria C
authors.initials: MC
authors.lastname: Gomez-Fernandez
authors.forename: Natalia
authors.initials: N
authors.lastname: Burgos-Alonso
authors.forename: Isabel
authors.initials: I
authors.lastname: Andia
mesh_terms: D002908:Chronic Disease; D002985:Clinical Protocols; D004311:Double-Blind Method; D006801:Humans; D017063:Outcome Assessment, Health Care; D053657:Platelet-Rich Plasma; D012107:Research Design; D018401:Sample Size; D052256:Tendinopathy / Q000628:therapy*