title: Role of α1 adrenergic antagonism in the mechanism of action of iloperidone: reducing extrapyramidal symptoms.
abstract: The low incidence of extrapyramidal side effects associated with the atypical antipsychotic iloperidone may be linked to its unique binding profile of high affinity antagonism of both α1 adrenergic receptors and serotonin 2A receptors.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000818:Animals; D001480:Basal Ganglia Diseases / Q000188:drug therapy*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000627:therapeutic use*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D007555:Isoxazoles; D010880:Piperidines; D058830:Serotonin 5-HT2 Receptor Antagonists; C081732:iloperidone; D004298:Dopamine