title: The association of heavy metal of blood and serum in the Alzheimer's diseases.
abstract: This study has attempted to establish an analysis method through validation against heavy metals in the body (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer's disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer's disease group. In this study, Pb and Cd levels in the blood and serum were validation using ICP-MS. For analysis of Hg levels in the blood and serum, the gold amalgamation-based 'Direct Mercury Analyzer' has been used. According to an analysis on the heavy metal concentration (Pb, Cd and Hg concentration) in the blood, Cd concentration was high in the Alzheimer's disease group. In the serum, on the contrary, Pb and Hg were high in the Alzheimer's disease group. For analysis of correlations between heavy metal levels in the blood and serum and Alzheimer's disease, t-test has been performed. Even though correlations were observed between the blood lead levels and Alzheimer's disease, they were statistically insignificant because the concentration was higher in a control group. No significance was found in Cd and Hg. In the serum, on the other hand, no statistical significance was found between the heavy metal (Pb, Cd and Hg) and Alzheimer's disease. In this study, no statistical significance was observed between heavy metal and decrease in cognitive intelligence. However, it appears that a further study needs to be performed because the results of the conventional studies were inconsistent.
authors.affiliation: Advanced Analysis Center, Korea Institute of Science and Technology, Seoul 136-791, Korea ; Department of Environmental Health, College of Health Sciences, Korea University, Seoul 136-703, Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Dal-Woong
authors.initials: DW
authors.lastname: Choi
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Lee
authors.forename: Jun-Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Pyo
authors.forename: Ho-Jang
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Kyung-Su
authors.initials: KS
authors.lastname: Park
keywords: Alzheimer’s diseases; Association; Biomonitoring; Heavy metal