title: Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia.
abstract: OBJECTIVE
  To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia.
  
  
  METHODS
  Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined.
  
  
  RESULTS
  B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.
  
  
  CONCLUSIONS
  Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.
authors.affiliation: Centre for Reproductive Biology and.
authors.forename: Amie J
authors.initials: AJ
authors.lastname: Moyes
authors.forename: Gillan A
authors.initials: GA
authors.lastname: Gray
authors.forename: Fiona C
authors.initials: FC
authors.lastname: Denison
mesh_terms: D000328:Adult; D001158:Arteries / Q000378:metabolism / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009215:Myometrium / Q000098:blood supply* / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D043783:Receptor, Bradykinin B1 / Q000819:agonists / Q000378:metabolism*; D043782:Receptor, Bradykinin B2 / Q000819:agonists / Q000378:metabolism*; D014664:Vasodilation
chemical_list: D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D009569:Nitric Oxide