title: [Transcriptional regulation of chondrogenesis and articular cartilage destruction].
abstract: In 20th century, cartilage researches were performed by in vitro culture system, and current trend of mouse genetic approaches makes a good progress in the studies of molecular mechanisms underlying chondrogenesis. Sox family and Runt family transcription factors play central roles in chondrogenesis and pathogenesis of osteoarthritis. In this review, we would like to introduce recent progress in understanding of molecular regulation of transcription factors in chondrogenesis and articular cartilage destruction.
authors.affiliation: Department of Orthopedic Surgery, Gifu University, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Akiyama
authors.forename: Kazu
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D051722:ADAM Proteins / Q000502:physiology; D000071116:ADAMTS5 Protein; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002358:Cartilage, Articular / Q000473:pathology* / Q000503:physiopathology; D002454:Cell Differentiation / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology; D020219:Chondrogenesis / Q000235:genetics* / Q000502:physiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D056892:Mediator Complex / Q000502:physiology; D051379:Mice; D010003:Osteoarthritis / Q000235:genetics*; D055758:SOX9 Transcription Factor; D055755:SOXD Transcription Factors; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics* / Q000502:physiology; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; D051792:Basic Helix-Loop-Helix Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D056892:Mediator Complex; D055758:SOX9 Transcription Factor; D055755:SOXD Transcription Factors; D014157:Transcription Factors; D000099162:Endothelial PAS Domain-Containing Protein 1; C460107:MED12 protein, human; C121532:ADAMTS5 protein, human