title: Iodine-131 radiolabeling of poly ethylene glycol-coated gold nanorods for in vivo imaging.
abstract: Gold nanorods (GNRs) can be used in various biomedical applications; however, very little is known about their in vivo tissue distribution by radiolabeling. Here, we have developed a rapid and simple method with high yield and without disturbing their optical properties for radiolabeling of gold rods with iodine-131 in order to track in vivo tissue uptake of GNRs after systemic administration by biodistribution analysis and γ-imaging. Following intravenous injection into rat, PEGylated GNRs have much longer blood circulation times.
authors.affiliation: Department of Energy Engineering, Sharif University of Technology, Azadi Ave. P.O. Box 113658639, Tehran, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Eskandari
authors.forename: Kamal
authors.initials: K
authors.lastname: Yavari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Outokesh
authors.forename: Sodeh
authors.initials: S
authors.lastname: Sadjadi
authors.forename: Seyed Javad
authors.initials: SJ
authors.lastname: Ahmadi
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D007553:Isotope Labeling; D053768:Metal Nanoparticles / Q000032:analysis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011092:Polyethylene Glycols; D006046:Gold
keywords: biodistribution; gold nanorods; iodine-131; radiolabeling; γ-imaging