title: B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.
abstract: In kidney transplantation, the composition of the B-cell compartment is increasingly identified as an important determinant for graft outcome. Whereas naive and transitional B cells have been associated with long-term allograft survival and operational tolerance, memory B cells have been linked to graft rejection and graft loss. Chronic antibody-mediated rejection now represents a major complication in transplantation and is a challenge in current therapeutics. Here, we show that patients with chronic antibody-mediated rejection display a unique B-cell phenotype with a reduced ratio of activated to memory B cells associated with an impaired immunosuppressive activity. The regulatory functions of the B cells depended on their maturation status. Thus, phenotypic and functional analyses of the B-cell compartment may be indicated for appropriate follow-up after transplantation and drive therapy in the establishment of transplant tolerance processes.
authors.affiliation: EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Nouël
authors.affiliation: 1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Department of Nephrology, CHRU Cavale Blanche, Brest, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ségalen
authors.affiliation: 1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Laboratory of Immunology, CHRU Morvan, Brest, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Jamin
authors.affiliation: Department of Anatomopathology, CHRU Morvan, Brest, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Doucet
authors.affiliation: Department of Nephrology Transplantation, CHRU Strasbourg, Strasbourg, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Caillard
authors.affiliation: 1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Laboratory of Immunology, CHRU Morvan, Brest, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Renaudineau
authors.affiliation: EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
authors.affiliation: 1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Department of Nephrology, CHRU Cavale Blanche, Brest, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Le Meur
authors.affiliation: 1] EA2216 'Immunology and Pathology' Université de Brest, SFR ScinBios, LabEx IGO 'Immunotherapy Graft, Oncology', Brest, France [2] Laboratory of Immunology, CHRU Morvan, Brest, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Hillion
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000502:physiology