title: Zebrafish as a model system to study toxicology.
abstract: Monitoring and assessing the effects of contaminants in the aquatic eco-environment is critical in protecting human health and the environment. The zebrafish has been widely used as a prominent model organism in different fields because of its small size, low cost, diverse adaptability, short breeding cycle, high fecundity, and transparent embryos. Recent studies have demonstrated that zebrafish sensitivity can aid in monitoring environmental contaminants, especially with the application of transgenic technology in this area. The present review provides a brief overview of recent studies on wild-type and transgenic zebrafish as a model system to monitor toxic heavy metals, endocrine disruptors, and organic pollutants for toxicology. The authors address the new direction of developing high-throughput detection of genetically modified transparent zebrafish to open a new window for monitoring environmental pollutants.
authors.affiliation: Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Dai
authors.forename: Yong-Fang
authors.initials: YF
authors.lastname: Jia
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Bian
authors.forename: Qin-Kai
authors.initials: QK
authors.lastname: Li
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Ma
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Chen
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Pei
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis*; D023421:Models, Animal; D014116:Toxicology / Q000379:methods; D015027:Zebrafish
chemical_list: D004785:Environmental Pollutants
keywords: Environmental pollution; Model system; Monitoring; Toxicology; Transgenic zebrafish