title: miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.
abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
authors.affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan, Department of Computer Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan, Molecular Bioinformatics Center, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan, Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan, and Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Sheng-Da
authors.initials: SD
authors.lastname: Hsu
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tseng
authors.forename: Sirjana
authors.initials: S
authors.lastname: Shrestha
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Lin
authors.forename: Anas
authors.initials: A
authors.lastname: Khaleel
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Chou
authors.forename: Chao-Fang
authors.initials: CF
authors.lastname: Chu
authors.forename: Hsi-Yuan
authors.initials: HY
authors.lastname: Huang
authors.forename: Ching-Min
authors.initials: CM
authors.lastname: Lin
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Ho
authors.forename: Ting-Yan
authors.initials: TY
authors.lastname: Jian
authors.forename: Feng-Mao
authors.initials: FM
authors.lastname: Lin
authors.forename: Tzu-Hao
authors.initials: TH
authors.lastname: Chang
authors.forename: Shun-Long
authors.initials: SL
authors.lastname: Weng
authors.forename: Kuang-Wen
authors.initials: KW
authors.lastname: Liao
authors.forename: I-En
authors.initials: IE
authors.lastname: Liao
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Liu
authors.forename: Hsien-Da
authors.initials: HD
authors.lastname: Huang
mesh_terms: D030561:Databases, Nucleic Acid; D004194:Disease / Q000235:genetics; D005786:Gene Expression Regulation; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D017423:Sequence Analysis, RNA; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger