title: [Serious sepsis treatment in intensive care departments in the Czech Republic -  EPOSS Project pilot results].
abstract: BACKGROUND
  Severe sepsis is still associated with significant morbidity and mortality, which is however different, as well as its management, depending on the region. What is the situation in the Czech Republic and what is the character of patients with severe sepsis is currently not known. The aim of the project is to describe the processes of care, outcome and characteristics of patients with severe sepsis admitted to the intensive care department of the Czech Republic.
  
  
  METHODS
  This is a multicentre and observational project with retrospective enrollment of patients who meet the criteria for severe sepsis before or within 24 hours after admission to selected intensive care units (ICU EPOSS).
  
  
  RESULTS
  394 patients were analyzed. Median age at admission was 66 (56- 76) years, males predominated (58.9%) and the median APACHE II score on admission was 25 (19- 32). Patients were predominantly medical (56.9%) and most were secondary admitted from other ICU (53.6%). Meeting the criteria of severe sepsis was most frequently within the period (± 4 hours) of admission the EPOSS ICU (77.6%). Median total fluid intake during the first 24 hours was 6,680 (4,840- 9,450) ml. Most patients required mechanical ventilation (58.4%). Compliance with the resuscitation bundle of severe sepsis in our group was very good and was associated with lower mortality of patients. Most frequently, the EPOSS ICU length of stay (LOS) was 7 (3- 15) days and median hospital LOS was 13 (8- 28) days. Hospital mortality in our cohort was 35.8%.
  
  
  CONCLUSIONS
  Introducing the project, which in its first stage obtained valuable and internationally comparable data about patients with severe sepsis admitted to the involved ICU in the Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Maláska
authors.forename: M
authors.initials: M
authors.lastname: Slezák
authors.forename: D
authors.initials: D
authors.lastname: Schwarz
authors.forename: J
authors.initials: J
authors.lastname: Jarkovský
authors.forename: M
authors.initials: M
authors.lastname: Adamus
authors.forename: K
authors.initials: K
authors.lastname: Cvachovec
authors.forename: V
authors.initials: V
authors.lastname: Cerný
authors.forename: P
authors.initials: P
authors.lastname: Dostál
authors.forename: M
authors.initials: M
authors.lastname: Fořtová
authors.forename: E
authors.initials: E
authors.lastname: Havel
authors.forename: I
authors.initials: I
authors.lastname: Herold
authors.forename: E
authors.initials: E
authors.lastname: Kasal
authors.forename: R
authors.initials: R
authors.lastname: Kula
authors.forename: J
authors.initials: J
authors.lastname: Maňák
authors.forename: M
authors.initials: M
authors.lastname: Matějovič
authors.forename: D
authors.initials: D
authors.lastname: Nalos
authors.forename: R
authors.initials: R
authors.lastname: Pařízková
authors.forename: A
authors.initials: A
authors.lastname: Sobáňová
authors.forename: V
authors.initials: V
authors.lastname: Srámek
authors.forename: J
authors.initials: J
authors.lastname: Tichý
authors.forename: R
authors.initials: R
authors.lastname: Turek
authors.forename: I
authors.initials: I
authors.lastname: Zýková
authors.forename: L
authors.initials: L
authors.lastname: Dušek
authors.forename: P
authors.initials: P
authors.lastname: Sevčík
authors.forename: Za Projekt
authors.initials: ZP
authors.lastname: Eposs
authors.forename: V
authors.initials: V
authors.lastname: Agalarev
authors.forename: P
authors.initials: P
authors.lastname: Bakalík
authors.forename: V
authors.initials: V
authors.lastname: Belanová
authors.forename: J
authors.initials: J
authors.lastname: Cerman
authors.forename: L
authors.initials: L
authors.lastname: Cíž
authors.forename: L
authors.initials: L
authors.lastname: Dadák
authors.forename: J
authors.initials: J
authors.lastname: Duba
authors.forename: J
authors.initials: J
authors.lastname: Fortunato
authors.forename: T
authors.initials: T
authors.lastname: Gabrhelík
authors.forename: R
authors.initials: R
authors.lastname: Gál
authors.forename: R
authors.initials: R
authors.lastname: Hůlek
authors.forename: O
authors.initials: O
authors.lastname: Hrdý
authors.forename: M
authors.initials: M
authors.lastname: Huchý
authors.forename: I
authors.initials: I
authors.lastname: Chytra
authors.forename: D
authors.initials: D
authors.lastname: Klimeš
authors.forename: J
authors.initials: J
authors.lastname: Klučka
authors.forename: M
authors.initials: M
authors.lastname: Kratochvíl
authors.forename: L
authors.initials: L
authors.lastname: Kosková
authors.forename: J
authors.initials: J
authors.lastname: Máca
authors.forename: O
authors.initials: O
authors.lastname: Mašlík
authors.forename: M
authors.initials: M
authors.lastname: Matysová
authors.forename: P
authors.initials: P
authors.lastname: Minarčíková
authors.forename: J
authors.initials: J
authors.lastname: Molnárová
authors.forename: H
authors.initials: H
authors.lastname: Ondrášková
authors.forename: M
authors.initials: M
authors.lastname: Pelichovská
authors.forename: J
authors.initials: J
authors.lastname: Polák
authors.forename: R
authors.initials: R
authors.lastname: Schwarz
authors.forename: J
authors.initials: J
authors.lastname: Sťásek
authors.forename: E
authors.initials: E
authors.lastname: Straževská
authors.forename: H
authors.initials: H
authors.lastname: Suchomelová
authors.forename: P
authors.initials: P
authors.lastname: Suk
authors.forename: P
authors.initials: P
authors.lastname: Stourač
authors.forename: J
authors.initials: J
authors.lastname: Tichý
authors.forename: M
authors.initials: M
authors.lastname: Wolfová
authors.forename: R
authors.initials: R
authors.lastname: Uvízl
authors.forename: H
authors.initials: H
authors.lastname: Zapletalová
authors.forename: J
authors.initials: J
authors.lastname: Zatloukal
authors.forename: I
authors.initials: I
authors.lastname: Zimová
mesh_terms: D000328:Adult; D000368:Aged; D003428:Cross Infection / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D018153:Czech Republic; D005260:Female; D019983:Guideline Adherence; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012121:Respiration, Artificial; D012151:Resuscitation; D012189:Retrospective Studies; D018805:Sepsis / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*