title: Healing of donor site in bone-tendon-bone ACL reconstruction accelerated with plasma rich in growth factors: a randomized clinical trial.
abstract: OBJECTIVE
  To determine whether the use of plasma rich in growth factors accelerates healing of the donor site in bone-tendon-bone anterior cruciate ligament (ACL) reconstruction (patellar graft). The use of the patellar graft presents post-operative problems such as anterior knee pain, which limits its use and leads to preference being taken for alternative grafts.
  
  
  METHODS
  A double-blind, randomized, clinical trial was performed comparing two groups of patients who underwent ACL reconstruction using patellar tendon graft and comparing the use of plasma rich in growth factors at the donor site after graft harvest in terms of local regeneration by ultrasound assessment.
  
  
  RESULTS
  The plasma rich in growth factors group shows earlier donor site regeneration in comparison with the control group (2 months earlier), with significant differences in the first 4 months of the follow-up.
  
  
  CONCLUSIONS
  The application of plasma rich in growth factors shows accelerated tissue regeneration processes with respect to the control group. This fact, together with the previously published with similar conclusions, can create a knowledge basis in order to set out new recovery guidelines following ACL reconstruction.
  
  
  METHODS
  Therapeutic study, Level I.
authors.affiliation: Orthopaedic Surgery, Artroscopia G.C., Fundación García-Cugat, Hospital Quirón Barcelona, Pza. Alfonso Comín 5-7, 08023, Barcelona, Spain, roberto6jas@gmail.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Seijas
authors.forename: Marta
authors.initials: M
authors.lastname: Rius
authors.forename: Oscar
authors.initials: O
authors.lastname: Ares
authors.forename: Montserrat
authors.initials: M
authors.lastname: García-Balletbó
authors.forename: Iván
authors.initials: I
authors.lastname: Serra
authors.forename: Ramón
authors.initials: R
authors.lastname: Cugat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D007718:Knee Injuries / Q000628:therapy*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D017847:Patellar Ligament / Q000637:transplantation*; D010949:Plasma; D011446:Prospective Studies; D013997:Time Factors; D014945:Wound Healing; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins