title: Centriole biogenesis in multiciliated cells.
abstract: Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost simultaneously. The molecular control mechanisms that govern centriole amplification in multiciliated cells are largely unknown. Two studies highlight Deup1 and CCDC78 as key players in this process.
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
authors.forename: Tang K
authors.initials: TK
authors.lastname: Tang
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000502:physiology*; D002502:Centrioles / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins
chemical_list: D018797:Cell Cycle Proteins; C586106:Cep63 protein, mouse; C586107:Deup1 protein, mouse; D008869:Microtubule-Associated Proteins