title: Disruptive influence.
abstract: Cachexia, a condition that kills about one-fifth of cancer patients, may be linked to Rb-a protein that is already linked to various cancers-moving from the cell nucleus to the cytoplasm.
authors.affiliation: Giulio Cossu is an eLife reviewing editor and is at the Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom giulio.cossu@manchester.ac.uk.
authors.forename: Giulio
authors.initials: G
authors.lastname: Cossu
authors.forename: Artal
authors.initials: A
authors.lastname: Moreno-Fortuny
authors.forename: Urmas
authors.initials: U
authors.lastname: Roostalu
mesh_terms: D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D016160:Retinoblastoma Protein / Q000378:metabolism*; D012518:Sarcomeres
chemical_list: D016160:Retinoblastoma Protein
keywords: CDK; Rb; phosphorylation; retinoblastoma protein; sarcomeric organization