title: Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide.
abstract: N-Acyl-N,O-acetals are present in a number of bioactive natural products, and this unusual functional group can act as a synthetic precursor to unstable reactive N-acylimines. In this paper, a variety of N-acyl-O-ethyl-N,O-acetals was concisely prepared under mild conditions mediated by titanium ethoxide (Ti(OEt)4). The method also offers a new strategy to make other O-alkyl-N,O-acetals. Furthermore, this strategy was extended to the synthesis of an analogue of the natural product turtschamide.
authors.affiliation: Sun Yat-sen University Cancer Center , State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Bingling
authors.initials: B
authors.lastname: Luo
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Yumin
authors.initials: Y
authors.lastname: Hu
authors.forename: A
authors.initials: A
authors.lastname: Ganesan
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Shijun
authors.initials: S
authors.lastname: Wen
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014025:Titanium / Q000737:chemistry*
chemical_list: D000080:Acetals; C009495:titanium dioxide; D014025:Titanium