title: Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers.
abstract: The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Woraphat
authors.initials: W
authors.lastname: Ratta-apha
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: hishipon@med.kobe-u.ac.jp.
authors.forename: Akitoyo
authors.initials: A
authors.lastname: Hishimoto
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Mouri
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Shiroiwa
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Sasada
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Masakuni
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okazaki
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Irwan
authors.initials: I
authors.lastname: Supriyanto
authors.affiliation: Department of Legal Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Migiwa
authors.initials: M
authors.lastname: Asano
authors.affiliation: Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ueno
authors.affiliation: Department of Neuropsychiatry, Kinki University School of Medicine, Osaka, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirakawa
authors.affiliation: Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013405:Suicide
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins
keywords: Completed suicide; Disrupted-in-schizophrenia 1; Haplotype analysis