title: Palladium-catalyzed asymmetric 1,6-addition of diarylphosphines to α,β,γ,δ-unsaturated sulfonic esters: controlling regioselectivity by rational selection of electron-withdrawing groups.
abstract: Palladium-catalyzed asymmetric 1,6-addition of diarylphosphines to electron-deficient dienes was developed through rational selection of electron-withdrawing groups on the dienes. Various chiral allylic phosphine derivatives were synthesized in good yields with high enantioselectivity (up to 96% ee).
authors.affiliation: School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Junzhu
authors.initials: J
authors.lastname: Lu
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Duan
mesh_terms: D002384:Catalysis; D004583:Electrons; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry*
chemical_list: D004952:Esters; D010720:Phosphines; D013451:Sulfonic Acids; D010165:Palladium; C044646:phosphine