title: Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2.
abstract: Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus. Nausea, vomiting, diarrhea, abdominal pain, and anorexia are the most common adverse effects encountered during treatment. Lactic acidosis is a serious side effect seen with metformin use, and while the incidence of lactic acidosis is similar to other oral antidiabetics, metformin is not recommended to patients with certain risk factors, such as cardiovascular, pulmonary, and renal and liver failure. We describe a chronic hemodialysis patient treated with metformin, presenting to the nephrology department with altered mental status.
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Altun
authors.forename: Bülent
authors.initials: B
authors.lastname: Kaya
authors.forename: Saime
authors.initials: S
authors.lastname: Paydaş
authors.forename: Barış
authors.initials: B
authors.lastname: Sarıakçalı
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Karayaylalı
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000368:Aged; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D006435:Renal Dialysis / Q000379:methods*; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin
keywords: Hemodialysis; lactic acidosis; metformin; type 2 diabetes mellitus