title: Polymeric complexes of isonicotinic acid hydrazide with antituberculosis effects.
abstract: We studied the effects of an analogue of isonicotinic acid hydrazide on the treatment course of experimental tuberculosis. Complex analysis has demonstrated the efficiency of isonicotinic acid hydrazide immobilized on a carrier that consisted of water-soluble cation-active analogue of chitosan (N-chlorohydroxypropyl chitosan) in a complex with cobalt ions in the therapy of experimental tuberculosis. Immunostimulating activity of the polymeric metal complex was revealed. The obtained data can be used for the development of highly effective methods for tuberculosis treatment.
authors.affiliation: Voronezh State University; Peoples' Friendship University of Russia, Moscow; N. S. Pokhvisneva Voronezh Regional Clinical Tuberculosis Dispensary, Voronezh, Russia. pfi.pharm@mail.ru.
authors.forename: A I
authors.initials: AI
authors.lastname: Slivkin
authors.forename: V L
authors.initials: VL
authors.lastname: Lapenko
authors.forename: A I
authors.initials: AI
authors.lastname: Bychuk
authors.forename: S N
authors.initials: SN
authors.lastname: Suslina
authors.forename: D A
authors.initials: DA
authors.lastname: Slivkin
authors.forename: S V
authors.initials: SV
authors.lastname: Kornienko
authors.forename: A S
authors.initials: AS
authors.lastname: Belenova
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007538:Isoniazid / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012756:Sheep; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D056831:Coordination Complexes; D003035:Cobalt; D007538:Isoniazid