title: Chlorhexidine gel associated with papain in pulp tissue dissolution.
abstract: OBJECTIVE
  This study aimed to evaluate the capacity of 2% chlorhexidine gel associated with 8% papain gel in comparison with 5.25% sodium hypochlorite in bovine pulp tissue dissolution.
  
  
  METHODS
  Ninety bovine pulps of standardized sizes were used and fragmented into 5-mm sizes. The fragments were removed from the root middle third region. They were divided into 6 experimental groups (n = 15), 1) 8% papain; 2) 2% chlorhexidine; 3) 2% chlorhexidine associated with 8% papain; 4) 0.9% saline solution; 5) 2.5% sodium hypochlorite; and 6) 5.25% sodium hypochlorite. The pulp fragments were weighed and put into immobile test tubes for dissolution for time intervals of 30, 60, 90, and 120 min.
  
  
  RESULTS
  The 5.25% sodium hypochlorite had greater dissolution potential than the pure papain, and when associated with chlorhexidine, both promoted greater dissolution than did the saline solution and 2% chlorhexidine groups (p < 0.05). The 2.5% sodium hypochlorite promoted dissolution to a lesser extent than the groups with papain within a period of 30 min (p < 0.05), but, was comparable to the saline solution and chlorhexidine. After 120 min, the 2.5% and 5.25% sodium hypochlorite promoted dissolution of 100% of the pulp fragments, and papain, 61%, while chlorhexidine associated with papain and chlorhexidine alone dissolved only 55% and 3%, respectively.
  
  
  CONCLUSIONS
  The 8% papain in gel, both alone and in association with chlorhexidine, was able to dissolve bovine pulp tissue, but to a lesser extent than did 5.25% sodium hypochlorite.
authors.affiliation: Southwest Bahia State University-UESB, Jequié, Bahia, Brazil.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Couto De Oliveira
authors.forename: Caio Souza
authors.initials: CS
authors.lastname: Ferraz
authors.forename: Carlos Vieira
authors.initials: CV
authors.lastname: Andrade Júnior
authors.forename: Matheus Melo
authors.initials: MM
authors.lastname: Pithon
keywords: Chlorhexidine; Endodontics; Papain