title: Association of a VDR gene polymorphism with risk of colorectal cancer in Kashmir.
abstract: Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.
authors.affiliation: Department of Biochemistry, University of Kashmir, Kashmir, India E-mail : bbcganai@gmail.com.
authors.forename: Sabha
authors.initials: S
authors.lastname: Rasool
authors.forename: Showkat Ahmad
authors.initials: SA
authors.lastname: Kadla
authors.forename: Tanzeela
authors.initials: T
authors.lastname: Khan
authors.forename: Falak
authors.initials: F
authors.lastname: Qazi
authors.forename: Nisar Ahmad
authors.initials: NA
authors.lastname: Shah
authors.forename: Javed
authors.initials: J
authors.lastname: Basu
authors.forename: Bilal Ahmad
authors.initials: BA
authors.lastname: Khan
authors.forename: Qulsum
authors.initials: Q
authors.lastname: Ahktar
authors.forename: Aga Syed
authors.initials: AS
authors.lastname: Sameer
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Ganai
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: D018167:Receptors, Calcitriol