title: A new cyclic tetrapeptide from an endophytic Streptomyces sp. YIM67005.
abstract: One new cyclic tetrapeptide, cyclo(L-Tyr-L-Pro-L-Phe-trans-4-hydroxy-L-Pro) (1), together with two known cyclodipeptides, cyclo(L-Phe-trans-4-hydroxy-L-Pro) (2) and cyclo(L-Val-L-Tyr) (3), were isolated from the fermentation broth of Streptomyces sp. YIM67005 associated with Inula cappa DC. The planar structure of compound 1 was determined on the basis of spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by the application of the advanced Marfey method. The cytotoxicity and antimicrobial activity of compound 1 were investigated.
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Zijun
authors.initials: Z
authors.lastname: Xiong
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents; D001408:Bacillus anthracis / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002681:China; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010456:Peptides, Cyclic; C000591420:cyclo(L-Tyr-L-Pro-L-Phe-trans-4-hydroxy-L-Pro)