title: High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus.
abstract: The involvement of the hippocampus (HC) in episodic memory is well accepted; however it is unclear how each subfield within the HC contributes to memory function. Recent magnetic resonance imaging (MRI) studies suggest differential involvement of hippocampal subfields and subregions in episodic memory. However, most structural MRI studies have examined the HC subfields within a single subregion of the HC and used specialised experimental memory paradigms. The purpose of the present study was to determine the association between volumes of HC subfields throughout the entire HC structure and performance on standard neuropsychological memory tests in a young, healthy population. We recruited 34 healthy participants under the age of 50. MRI data was acquired with a fast spin echo (FSE) sequence yielding a 0.52×0.68×1.0 mm(3) native resolution. The HC subfields - the cornu ammonis 1-3 (CA), dentate gyrus (DG), and subiculum (SUB) - were segmented manually within three hippocampal subregions using a previously defined protocol. Participants were administered the Wechsler Memory Scale, 4th edition (WMS-IV) to assess performance in episodic memory using verbal (Logical Memory, LM) and visual (Designs, DE; visual-spatial memory, DE-Spatial; visual-content memory, DE-Content) memory subtests. Working memory subtests (Spatial Addition, SA; and Symbol Span, SSP) were included as well. Working memory was not associated with any HC volumes. Volumes of the DG were correlated with verbal memory (LM) and visual-spatial memory (DE-Spatial). Posterior CA volumes correlated with both visual-spatial and visual-object memory (DE-Spatial, DE-Content). In general, anterior subregion volumes (HC head) correlated with verbal memory, while some anterior and many posterior HC subregion volumes (body and tail) correlated with visual memory scores (DE-Spatial, DE-Content). In addition, while verbal memory showed left-lateralized associations with HC volumes, visual memory was associated with HC volumes bilaterally. This the first study to examine the associations between hippocampal subfield volumes across the entire hippocampal formation with performance in a set of standard memory tasks.
authors.affiliation: Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: S G
authors.initials: SG
authors.lastname: Travis
authors.affiliation: Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Fujiwara
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Radomski
authors.affiliation: Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2V2.
authors.forename: F
authors.initials: F
authors.lastname: Olsen
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Carter
authors.affiliation: Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2V2.
authors.forename: P
authors.initials: P
authors.lastname: Seres
authors.affiliation: Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2V2. Electronic address: nikolai@ualberta.ca.
authors.forename: N V
authors.initials: NV
authors.lastname: Malykhin
mesh_terms: D000328:Adult; D000367:Age Factors; D001931:Brain Mapping; D018891:Dentate Gyrus / Q000033:anatomy & histology; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D061212:Memory, Episodic; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size; D013028:Space Perception; D013067:Speech Perception; D014796:Visual Perception; D055815:Young Adult
keywords: Episodic memory; Hippocampus; Medial temporal lobe; Structural MRI; Subfields; Wechsler Memory Scale