title: Peri-infarct zone characterized by cardiac magnetic resonance imaging is directly associated with the inflammatory activity during acute phase myocardial infarction.
abstract: Enhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 ± 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type α (TNF-α; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-α (r = 0.5), delta-TNF-α (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ.
authors.affiliation: University of Brasilia Medical School (UnB), Brasília, DF, Brazil.
authors.forename: Jose C
authors.initials: JC
authors.lastname: Quinaglia e Silva
authors.forename: Otavio Rizzi
authors.initials: OR
authors.lastname: Coelho-Filho
authors.forename: Joalbo M
authors.initials: JM
authors.lastname: Andrade
authors.forename: Thiago
authors.initials: T
authors.lastname: Quinaglia
authors.forename: Rodrigo G P
authors.initials: RG
authors.lastname: Modolo
authors.forename: Breno O
authors.initials: BO
authors.lastname: Almeida
authors.forename: Rob J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: Michael
authors.initials: M
authors.lastname: Jerosch-Herold
authors.forename: Otavio Rizzi
authors.initials: OR
authors.lastname: Coelho
authors.forename: Andrei C
authors.initials: AC
authors.lastname: Sposito
mesh_terms: D001145:Arrhythmias, Cardiac / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D016757:Death, Sudden, Cardiac / Q000473:pathology*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007376:Interleukin-2 / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology* / Q000473:pathology*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508594:IL2 protein, human; D007376:Interleukin-2; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein