title: Stimulatory effect of volatile urinary components from intact mice on the proliferative activity of splenic lymphoid tissue in irradiated animals.
abstract: Immunohistochemical and morphometric analyses have demonstrated long-distance stimulatory effects of the natural volatile components of the urine of intact mice on the proliferation of splenic lymphocytes in mice exposed to a single total γ-irradiation in a dose of 1 Gy. These results are in line with the data on stimulation of the humoral immune response to thymus-dependent antigen in irradiated mice exposed to urine specimens of intact animals.
authors.affiliation: Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk, Russia. surinov@mrrc.obninsk.ru.
authors.forename: A F
authors.initials: AF
authors.lastname: Tsyb
authors.forename: B P
authors.initials: BP
authors.lastname: Surinov
authors.forename: V V
authors.initials: VV
authors.lastname: Yuzhakov
authors.forename: D V
authors.initials: DV
authors.lastname: Shpagin
authors.forename: L N
authors.initials: LN
authors.lastname: Bandurko
authors.forename: L N
authors.initials: LN
authors.lastname: Mihina
authors.forename: N K
authors.initials: NK
authors.lastname: Fomina
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002678:Chimera / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005720:Gamma Rays; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000528:radiation effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012756:Sheep; D015398:Signal Transduction / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D055549:Volatile Organic Compounds / Q000494:pharmacology* / Q000652:urine; D014916:Whole-Body Irradiation
chemical_list: D000906:Antibodies; D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen; D055549:Volatile Organic Compounds