title: Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model.
abstract: Alzheimer's disease (AD), the most common age-dependent neurodegenerative disorder, produces a progressive decline in cognitive function. The metabolic mechanism of AD has emerged in recent years. In this study, we used multivariate analyses of gas chromatography-mass spectrometry measurements to determine that learning and retention-related metabolic profiles are altered during aging in the hippocampus of the senescence-accelerated mouse prone 8 (SAMP8). Alterations in 17 metabolites were detected in mature and aged mice compared to young mice (13 decreased and 4 increased metabolites), including metabolites related to dysfunctional lipid metabolism (significantly increased cholesterol, oleic acid, and phosphoglyceride levels), decreased amino acid (alanine, serine, glycine, aspartic acid, glutamate, and gamma-aminobutyric acid), and energy-related metabolite levels (malic acid, butanedioic acid, fumaric acid, and citric acid), and other altered metabolites (increased N-acetyl-aspartic acid and decreased pyroglutamic acid, urea, and lactic acid) in the hippocampus. All of these alterations indicated that the metabolic mechanisms of age-related cognitive impairment in SAMP8 mice were related to multiple pathways and networks. Lipid metabolism, especially cholesterol metabolism, appears to play a distinct role in the hippocampus in AD.
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Hualong
authors.initials: H
authors.lastname: Wang
authors.affiliation: The School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Kaoqi
authors.initials: K
authors.lastname: Lian
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Columbia University, New York, NY, USA.
authors.forename: Sheng-Han
authors.initials: SH
authors.lastname: Kuo
authors.affiliation: Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Geng
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qiang
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, PR China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D055442:Metabolome / Q000502:physiology*; D051379:Mice
keywords: Aging; Alzheimer's disease; cholesterol; gas chromatography-mass spectrometry; hippocampus; metabolic profiles