title: Quantitative comparison of analysis methods for spectroscopic optical coherence tomography.
abstract: Spectroscopic optical coherence tomography (sOCT) enables the mapping of chromophore concentrations and image contrast enhancement in tissue. Acquisition of depth resolved spectra by sOCT requires analysis methods with optimal spectral/spatial resolution and spectral recovery. In this article, we quantitatively compare the available methods, i.e. the short time Fourier transform (STFT), wavelet transforms, the Wigner-Ville distribution and the dual window method through simulations in tissue-like media. We conclude that all methods suffer from the trade-off in spectral/spatial resolution, and that the STFT is the optimal method for the specific application of the localized quantification of hemoglobin concentration and oxygen saturation.
authors.affiliation: Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, P.O Box 22700, NL-1100 DE Amsterdam, The Netherlands.
authors.forename: Nienke
authors.initials: N
authors.lastname: Bosschaart
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
authors.forename: Maurice C G
authors.initials: MC
authors.lastname: Aalders
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Faber
keywords: (030.1640) Coherence; (070.4790) Spectrum analysis; (160.4760) Optical properties; (170.6510) Spectroscopy, tissue diagnostics