title: Endometrial injury may increase the clinical pregnancy rate in normoresponders undergoing long agonist protocol ICSI cycles with single embryo transfer.
abstract: OBJECTIVE
  To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo transfer.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  One hundred and eighteen women (age <35 years, normoresponders with Grade I or II embryos for transfer) were included. Women in the intervention group (n=56) underwent endometrial biopsy on Day 3 of the menstrual cycle following downregulation. Women in the control group (n=62) did not undergo endometrial biopsy.
  
  
  RESULTS
  The clinical and embryological characteristics were comparable in the two groups, and no significant difference was found in the fertilization rates (66.32% in the intervention group vs. 70.23% in the control group). The clinical pregnancy rate was 48.2% in the intervention group and 29.0% in the control group (p=0.025). Endometrial injury may increase the clinical pregnancy rate (odds ratio 2.27). The 'take home baby' rates were 33.9% and 17.7% in the intervention and control groups, respectively (p=0.035).
  
  
  CONCLUSIONS
  Assisted reproductive technology treatment that is preceded by endometrial injury may increase the clinical pregnancy rate in women undergoing long agonist protocol ICSI cycles with single embryo transfer.
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey. Electronic address: drsuleymanguven@yahoo.com.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
authors.forename: Cavit
authors.initials: C
authors.lastname: Kart
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
authors.forename: Mesut A
authors.initials: MA
authors.lastname: Unsal
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Yildirim
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
authors.forename: Ersan
authors.initials: E
authors.lastname: Odaci
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Yulug
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D004717:Endometrium / Q000293:injuries*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D056826:Single Embryo Transfer / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
keywords: ART; Clinical pregnancy; Endometrial injury; Single embryo transfer