title: A nonadjuvanted transcutaneous tetanus patch is effective in boosting anti-tetanus toxoid immune responses.
abstract: Dry tetanus toxoid (TTx) patches were formulated without any adjuvant, with excipients to impart antigen stabilization and to enhance skin delivery. The booster effects of the TTx patches were assessed using a guinea pig model. The study revealed significant rises in TTx IgG titers induced by the TTx patches after a low-dose subcutaneous (s.c.) prime with TTx adsorbed to aluminum hydroxide. The TTx patch can therefore be considered an effective alternative to a subcutaneous booster.
authors: Valneva Austria GmbH, Vienna, Austria.
authors: Robert C
authors: RC
authors: Seid
authors: Christoph
authors: C
authors: Reinisch
authors: Robert
authors: R
authors: Schlegl
authors: Michael
authors: M
authors: Moehlen
authors: Andreas
authors: A
authors: Meinke
authors: Urban
authors: U
authors: Lundberg
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000992:Antitoxins / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D007117:Immunization, Secondary / Q000379:methods*; D007074:Immunoglobulin G / Q000097:blood; D013742:Tetanus / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000992:Antitoxins; D007074:Immunoglobulin G; D013745:Tetanus Toxoid