title: FokI polymorphism in vitamin D receptor gene and risk of breast cancer among Caucasian women.
abstract: Vitamin D plays a central role in cellular proliferation, apoptosis induction, and tumor growth suppression. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. A series of epidemiological studies have examined the association between the VDR FokI polymorphism and breast cancer risk, but the findings remain inconclusive. Fifteen eligible case-control studies involving 15,681 cancer cases and 20,632 control subjects were identified through searching PubMed, Embase, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association. Heterogeneity across studies was examined with the chi-square-based Q test and the I (2) index. Begg's and Egger's test were also performed to determine publication bias. All statistical data were analyzed by STATA software. The combined estimates did not show significant risks correlated with the FokI polymorphism. However, we found an increased risk in the subgroup analysis by source of control (OR = 1.11, 95% CI = 1.01-1.22; heterogeneity test: P = 0.116, I(2) = 0.0% for ff vs FF; OR = 1.10, 95% CI = 1.01-1.21; heterogeneity test: P = 0.832, I(2) = 0.0% for ff vs Ff + FF). This meta-analysis suggests that the presence of FokI polymorphism may contribute to the risk of breast cancer in Caucasians.
authors: Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, No.10 Changjiang Zhilu, Yuzhong District, Chongqing, 400042, China.
authors: Jin-lu
authors: JL
authors: Shan
authors: Nan
authors: N
authors: Dai
authors: Xue-qin
authors: XQ
authors: Yang
authors: Cheng-yuan
authors: CY
authors: Qian
authors: Zhen-zhou
authors: ZZ
authors: Yang
authors: Feng
authors: F
authors: Jin
authors: Mengxia
authors: M
authors: Li
authors: Dong
authors: D
authors: Wang
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific