title: Risk of preterm delivery associated with prior treatment of cervical precancerous lesion according to the depth of the cone.
abstract: The aim of this study was to evaluate the impact of the surgical excisional procedures for cervical intraepithelial neoplasia (CIN) treatment both on subsequent fertility (cervical factor) and pregnancy complication (risk of spontaneous preterm delivery). We retrospectively analyzed 236 fertile women who underwent conization for CIN. We included in the study 47 patients who carried on pregnancy and delivered a viable fetus. Patients were asked about postconization pregnancies, obstetrical outcomes, and a possible diagnosis of secondary infertility caused by cervical stenosis. We evaluated the depth of surgical excision, the timing between cervical conization and subsequent pregnancies, surgical technique, and maternal age at delivery. We recorded 47 deliveries, 10 cases of preterm delivery; 8 of them were spontaneous. The depth of surgical excision showed a statistically significant inverse correlation with gestational age at birth. The risk of spontaneous preterm delivery increased when conization depth exceeded a cut-off value of 1.5 cm. Our data do not demonstrated a relation between conization and infertility due to cervical stenosis.
authors: Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
authors: Roberto
authors: R
authors: Berretta
authors: Salvatore
authors: S
authors: Gizzo
authors: Andrea
authors: A
authors: Dall'Asta
authors: Eleonora
authors: E
authors: Mazzone
authors: Michela
authors: M
authors: Monica
authors: Laura
authors: L
authors: Franchi
authors: Francesca
authors: F
authors: Peri
authors: Tito Silvio
authors: TS
authors: Patrelli
authors: Alberto
authors: A
authors: Bacchi Modena
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery; D019092:Conization; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*