title: An autochthonous case of canine visceral leishmaniasis in Korea.
abstract: A 12-year-old spayed female mixed-bred dog presented with nasal bleeding of 2 days duration and a skin nodule in the left flank. No abnormalities were found in coagulation profiles and blood pressure. Cytological evaluation of the nodule revealed numerous characteristic round organisms having a nucleus and a bar within macrophages and in the background, consistent with leishmaniasis. In vitro culture was unsuccessful but PCR of the nodular aspirate identified the organisms as Leishmania infantum, and the final diagnosis was canine leishmaniasis. No history of travel to endemic countries was noted. Because the dog had received a blood transfusion 2 years before the illness, serological screening tests were performed in all donor dogs of the commercial blood bank using the commercial Leishmania ELISA test kit, and there were no positive results. Additional 113 dogs with hyperglobulinemia from Seoul were also screened with the same kits but no positive results were obtained. To the best of the author's knowledge this is the first autochthonous case of canine leishmaniasis in Korea.
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors: Dong Ha
authors: DH
authors: Bhang
authors: Ul Soo
authors: US
authors: Choi
authors: Hyun Jeong
authors: HJ
authors: Kim
authors: Kyoung-Oh
authors: KO
authors: Cho
authors: Sung-Shik
authors: SS
authors: Shin
authors: Hee-Jeong
authors: HJ
authors: Youn
authors: Cheol-Yong
authors: CY
authors: Hwang
authors: Hwa-Young
authors: HY
authors: Youn
mesh_terms: D000818:Animals; D001483:Base Sequence; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000175:diagnosis* / Q000453:epidemiology; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D015726:Giant Cells / Q000473:pathology; D018314:Leishmania infantum / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000662:veterinary*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015800:Protozoan Proteins / Q000235:genetics; D056910:Republic of Korea; D017422:Sequence Analysis, DNA / Q000662:veterinary; D012698:Serologic Tests / Q000662:veterinary
chemical_list: D016054:DNA, Protozoan; D004275:DNA, Ribosomal; D015800:Protozoan Proteins
keywords: Korea; Leishmania infantum; autochthonous leishmaniasis; dog