title: Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity.
abstract: Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrophage (TAM) entry into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with this pathway entraps TAMs in oxygenated areas, preventing their tumorigenic function.
authors: Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
authors: Lee B
authors: LB
authors: Rivera
authors: Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: gabriele.bergers@ucsf.edu.
authors: Gabriele
authors: G
authors: Bergers
mesh_terms: D000818:Animals; D008264:Macrophages / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D039942:Neuropilin-1 / Q000502:physiology*; D040121:Semaphorin-3A / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C488217:Sema3a protein, mouse; D040121:Semaphorin-3A; D039942:Neuropilin-1