title: Seroprevalence of measles IgG among HIV-1-infected and uninfected Kenyan adults.
abstract: Despite global efforts to reduce measles incidence, outbreaks continue to occur in developing countries where HIV-1-infected adults represent a vulnerable population. Immunization campaigns have targeted children, although little is known about the levels of measles protection in adult populations in Kenya. The objective of this study was to determine seroprevalence and titers of measles IgG among HIV-1-infected and uninfected adults in Nairobi, Kenya. The presence of anti-measles IgG was measured in cryopreserved serum of 257 HIV-1-infected and 367 uninfected adults using a commercial ELISA (Enzygnost, Germany). The measles IgG concentration was calculated for those samples that were positive. Overall, 96% of adults were measles seropositive and the mean measles IgG concentration among those who were seropositive was 4134 mIU/ml, which is well above previously reported protective levels. There was no statistical difference in seroprevalence or antibody concentration between the HIV-infected and HIV-uninfected groups. While local vaccination efforts and circulating measles infection likely contribute to this high measles seroprevalence rate, these data are unique to an urban population and may not reflect a country-wide distribution. Our results suggest that reduced immunity among HIV-1-infected adults is not a major contributor to measles resurgence in Kenya.
authors: Department of Medicine, University of Washington, Box 359909, 325 Ninth Avenue Seattle, WA 98104, USA; Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya. Electronic address: merkel.michele@yahoo.com.
authors: Michele
authors: M
authors: Merkel
authors: School of Medicine, University of Washington, Seattle, Washington, USA.
authors: Leila
authors: L
authors: Ben-Youssef
authors: Department of Epidemiology, University of Washington, Seattle, Washington, USA.
authors: Laura P
authors: LP
authors: Newman
authors: Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
authors: Veronicah
authors: V
authors: Gitome
authors: School of Public Health, Kenyatta University, Nairobi, Kenya.
authors: Ann
authors: A
authors: Gataguta
authors: Department of Medicine, University of Washington, Box 359909, 325 Ninth Avenue Seattle, WA 98104, USA; Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya; Department of Global Health, University of Washington, Seattle, Washington, USA.
authors: Barbara
authors: B
authors: Lohman-Payne
authors: Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya.
authors: Rose
authors: R
authors: Bosire
authors: Department of Medicine, University of Washington, Box 359909, 325 Ninth Avenue Seattle, WA 98104, USA; Department of Epidemiology, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA.
authors: Carey
authors: C
authors: Farquhar
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D003710:Demography; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D007109:Immunity; D007074:Immunoglobulin G / Q000097:blood*; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008457:Measles / Q000150:complications / Q000453:epidemiology*; D008459:Measles virus / Q000276:immunology*; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014505:Urban Population; D014611:Vaccination; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: Adult immunity; HIV; IgG antibody; Kenya; Measles; Sub-Saharan Africa