title: A review of the pharmacological mechanism of traditional Chinese medicine in the intervention of coronary heart disease and stroke.
abstract: In recent years, several researches have showed that Buyang Huanwu Decoction (BHD) possesses multiple target points in the intervention of diseases, and has same treatment effects on cerebrovascular diseases and cardiovascular diseases. But, there was no full report about the mechanistic and material basis in Brain-Heart concurrent treatment. The objective of the present study was to examine the pharmacological mechanism of traditional Chinese medicine in the intervention of coronary heart disease and stroke. We combined the HIT, PubChem, David Database resource and the networked pharmacology method to ultimately find out BHD's thirty-five potential brain-heart concurrent treatment target points, and preliminarily reveal BHD's material basis for treatment of cerebrovascular diseases and cardiovascular diseases. Finally, the study provided new information with the guidance meanings.
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Wenting
authors: W
authors: Zhang
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Kuo
authors: K
authors: Gao
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Jingwei
authors: J
authors: Liu
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Huihui
authors: H
authors: Zhao
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Juan
authors: J
authors: Wang
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Yubo
authors: Y
authors: Li
authors: Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
authors: Ghulam
authors: G
authors: Murtaza
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Jianxin
authors: J
authors: Chen
authors: Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
authors: Wei
authors: W
authors: Wang
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy*; D062126:Databases, Chemical; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D020521:Stroke / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; C460102:buyang huanwu
keywords: Brain-Heart concurrent treatment; Buyang Huanwu Decoction (BHD); Material basis; Pharmaceutical effect mechanism