title: Caregivers' willingness-to-pay for Alzheimer's disease medications in Canada.
abstract: We studied caregivers' willingness-to-pay for Alzheimer's disease drug therapy. We recruited 216 caregivers of persons with mild or moderate Alzheimer's disease and presented them with four scenarios describing a hypothetical Alzheimer's disease medication. The scenarios described the medication as capable of either treating the symptoms of disease or modifying the course of disease. The scenarios also presented two different probabilities of adverse effects occurrence, i.e., 0% or 30%. Most caregivers said they would pay out-of-pocket for the medication, with support for such payment ranging from 68% to 93%, depending on the specific scenario. The highest level of support was for the 'disease modifying and no adverse effects' scenario, while the lowest level was for the 'symptom treatment and 30% chance of adverse effects' scenario. On average, caregivers' monthly willingness-to-pay out-of-pocket for the medication ranged from $214 to $277 (Canadian dollars). Dollar amounts were highest for the 'disease modifying and no adverse effects' scenario and lowest for the 'symptom treatment and 30% chance of adverse effects' scenario. Support for out-of-pocket payment and specific dollar amounts were highest when the medication did not involve adverse effects. Caregivers placed more value on the absence of adverse effects than on drug efficacy.
authors: McMaster University, Canada oremusm@mcmaster.ca.
authors: Mark
authors: M
authors: Oremus
authors: McMaster University, Canada.
authors: Jean-Eric
authors: JE
authors: Tarride
authors: McMaster University, Canada.
authors: Eleanor
authors: E
authors: Pullenayegum
authors: McMaster University, Canada.
authors: Natasha
authors: N
authors: Clayton
authors: Gerry
authors: G
authors: Mugford
authors: Marshall
authors: M
authors: Godwin
authors: Allen
authors: A
authors: Huan
authors: Yves
authors: Y
authors: Bacher
authors: Juan-Manual
authors: JM
authors: Villalpando
authors: Sudeep S
authors: SS
authors: Gill
authors: Krista L
authors: KL
authors: Lanctôt
authors: Nathan
authors: N
authors: Herrmann
authors: McMaster University, Canada.
authors: Parminder
authors: P
authors: Raina
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000191:economics*; D002170:Canada; D017028:Caregivers; D003362:Cost-Benefit Analysis; D004358:Drug Therapy / Q000191:economics; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005382:Financing, Personal; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
keywords: Adverse effects; Alzheimer’s disease; caregiver; efficacy; medication; willingness-to-pay