title: The fluctuation-dissipation theorem for stochastic kinetics--implications on genetic regulations.
abstract: The Fluctuation-Dissipation theorem (FDT) connects the "memory" in the fluctuation in equilibrium to the response of a system after a perturbation, which has been a fundamental ground in many branches of physics. When viewing a cell as a stochastic biochemical system, the cell's response under a perturbation is related to its intrinsic steady-state correlation functions via the FDT, a theorem we derived and present in this work. FDT allows us to use the noise to derive dynamic response and infer dynamic properties in the system. We tested FDT's validity with gene regulation models and found that it is limited to the linear response. For an indirect regulation pathway where unknown components may exist, FDT still works within the linear response region. Thus, FDT may be used for systems with partial knowledge, and it is potentially possible to identify the existence of unobserved components. With FDT, the dynamic response can be composed of steady-state measurements without the complete detailed knowledge for the regulation or kinetics. The response function derived can give important insights into the dynamics and time scales of the system.
authors: Institute of Chemistry, Academia Sinica, 128, Section 2, Academia Road, Nankang, Taipei 115, Taiwan.
authors: Ching-Cher Sanders
authors: CC
authors: Yan
authors: Institute of Chemistry, Academia Sinica, 128, Section 2, Academia Road, Nankang, Taipei 115, Taiwan.
authors: Chao-Ping
authors: CP
authors: Hsu
mesh_terms: D007700:Kinetics; D016014:Linear Models; D008956:Models, Chemical; D017711:Nonlinear Dynamics; D011336:Probability; D013269:Stochastic Processes