title: Change in waist circumference and the progression of subclinical atherosclerosis in type 2 diabetes patients.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  We aimed to assess the effect of reducing body weight, waist circumference, and various metabolic parameters on the progression of carotid intima media thickness (IMT) in Korean type 2 diabetes patients.
  
  
  METHODS
  This study comprised of 173 patients. Anthropometric measurements, metabolic parameters, and carotid IMT were measured at baseline and 1 year later.
  
  
  RESULTS
  There were significant differences in waist circumference, HbA1c, and mean left and right IMT after 1 year. The change in waist circumference correlated with changes in HbA1c and changes in right and left IMT after adjusting for age, sex, and medications that could influence the IMT. In multiple regression analysis, the change in waist circumference was a significant predictor of the progression of maximum right and left IMT, with a marginal significance for the latter, and mean left IMT, independent of changes in body weight, BMI, HbA1c level, and the use of anti-hyperlipidemic, antiplatelet agents and thiazolidinediones.
  
  
  CONCLUSIONS
  Controlling abdominal obesity seems to have a significant impact on the progression of subclinical atherosclerosis in patients with diabetes, and therefore, more efforts should be made toward reducing waist circumference to inhibit overt atherosclerotic diseases.
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Ji Sun
authors: JS
authors: Nam
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Minho
authors: M
authors: Cho
authors: Severance Institute for Vascular and Metabolic Research, Gangnam Severance Hospital, Seoul, Republic of Korea.
authors: Jong Suk
authors: JS
authors: Park
authors: Severance Institute for Vascular and Metabolic Research, Gangnam Severance Hospital, Seoul, Republic of Korea. Electronic address:acw@yuhs.ac.
authors: Chul Woo
authors: CW
authors: Ahn
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Bong Soo
authors: BS
authors: Cha
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Eun Jig
authors: EJ
authors: Lee
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Sung Kil
authors: SK
authors: Lim
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Kyung Rae
authors: KR
authors: Kim
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Hyun Chul
authors: HC
authors: Lee