title: [A case in which chromosome 5q deletion syndrome resistant to lenalidomide therapy transformed to refractory anemia with excess blasts].
abstract: An 80-year-old man was admitted to our hospital because of pancytopenia. Bone marrow examination revealed an increase in the number of dysplastic cells indicating trilineage dysplasia. A 5q13q31 deletion was the only genetic abnormality found, and consequently, 5q deletion syndrome was diagnosed. Although lenalidomide therapy was initiated, it had to be discontinued because of Stevens-Johnson syndrome, which occurred during the second course of treatment. There was no discernible hematological improvement, and bone marrow aspiration showed transformation to refractory anemia with excess blasts-2(RAEB-2)after lenalidomide therapy. However, by changing the therapy to azacitidine, cytogenetic remission was achieved.
authors: Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
authors: Michiko
authors: M
authors: Yamada
authors: Hiroyuki
authors: H
authors: Kuroda
authors: Wataru
authors: W
authors: Jomen
authors: Masahiro
authors: M
authors: Yoshida
authors: Shogo
authors: S
authors: Miura
authors: Tomoyuki
authors: T
authors: Abe
authors: Tamaki
authors: T
authors: Sakurai
authors: Shigeyuki
authors: S
authors: Fujii
authors: Masahiro
authors: M
authors: Maeda
authors: Miri
authors: M
authors: Fujita
authors: Kazuo
authors: K
authors: Nagashima
authors: Yohei
authors: Y
authors: Arihara
authors: Tasuku
authors: T
authors: Hirako
authors: Junji
authors: J
authors: Kato
mesh_terms: D000369:Aged, 80 and over; D000748:Anemia, Macrocytic / Q000188:drug therapy*; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D017809:Fatal Outcome; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis*; D013792:Thalidomide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide