title: CT-guided needle lung biopsy is possible during apneic oxygenation: a case series.
abstract: BACKGROUND
  It can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apneic oxygenation with a pulmonary standstill these movements can be hindered.
  
  
  METHODS
  Six patients with decreased lung function and suspicious lung nodules are presented. Under general anesthesia including a muscle relaxant and a cuffed tube in the trachea CT guided biopsy was prepared. Just before the biopsy the ventilation mode was switched to a continuous positive airway pressure of 5-10 cm H2O, maintaining 100% oxygen delivery without ventilation. If the position of the lung nodule was inconvenient for biopsy the pressure was increased to up to 17 cm H2O to expand the lungs to a better biopsy position. After retrieving the biopsy controlled ventilation was re-established and a finishing control CT-scan was performed. Blood gas analyses were performed with few minutes interval.
  
  
  RESULTS
  All biopsies were diagnostic. All patients survived the procedure with no major complications, but 3 patients developed pneumothorax. The length of apneic oxygenation was median 10 minutes (8-10 minutes). No major changes in vital parameters were observed, and in all patients the peripheral oxygen saturation was 100% throughout the procedure. The arterial oxygen tension rose to very high values and the lowest pH was 7.18.
  
  
  CONCLUSIONS
  It is possible to perform lung biopsies in selected patients with decreased lung function during apneic oxygenation in at least 10 minutes in a safe way.
authors: Department of Cardiothoracic Surgery, Centre for Cardiovascular Research, and Biomedical Research Laboratory, Aalborg University Hospital, Aalborg, Denmark. benedict@dadlnet.dk.
authors: Benedict
authors: B
authors: Kjaergaard
authors: Peter R
authors: PR
authors: Zepernick
authors: Annette
authors: A
authors: Bergmann
authors: Henrik K
authors: HK
authors: Jensen
authors: Milka
authors: M
authors: Mladenovic
authors: Bodil S
authors: BS
authors: Rasmussen