title: [Pulmonary CO/NO transfer: physiological basis, technical aspects and clinical impact].
abstract: Diseases affecting the alveolar-capillary membrane or the capillary blood vessels can impair pulmonary gas exchanges and lung diffusion. The single-breath transfer factor of the lung for carbon monoxide (TL,CO) is the classical technique for measuring gas transfer from the alveolus to the pulmonary capillary blood. Pulmonary gas exchanges can also be explored by the transfer factor of the lung for nitric oxide (TL,NO). TL,NO represents a better index for the diffusing capacity of the alveolar-capillary membrane whereas TL,CO is more influenced by red blood cell resistance. Membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc) derivated from TL,CO and TL,NO by the Roughton-Forster equation can give additional insights into pulmonary pathologies. The clinical impact of the CO/NO transfer has still to be precised even if this measurement seems to provide an alternative way of investigating the alveolar membrane and the blood reacting with the gas.
authors: Physiologie-explorations fonctionnelles, EA 3920, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France. Electronic address: bruno.degano@univ-fcomte.fr.
authors: B
authors: B
authors: Degano
authors: Université de Nantes, 44093 Nantes, France; Inserm UMR 1087, 8, quai Moncousu, 44007 Nantes, France; Service de médecine interne, CHU de Nantes, 44093 Nantes, France.
authors: F
authors: F
authors: Perrin
authors: Physiologie-explorations fonctionnelles, EA 3920, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France.
authors: T
authors: T
authors: Soumagne
authors: Université de Nantes, 44093 Nantes, France; Inserm UMR 1087, 8, quai Moncousu, 44007 Nantes, France; Service de médecine interne, CHU de Nantes, 44093 Nantes, France.
authors: C
authors: C
authors: Agard
authors: Laboratoire d'explorations fonctionnelles, institut du thorax, CHU de Nantes, 44093 Nantes, France; Université de Nantes, 44093 Nantes, France; Inserm UMR 1087, 8, quai Moncousu, 44007 Nantes, France.
authors: A
authors: A
authors: Chambellan
mesh_terms: D002248:Carbon Monoxide / Q000378:metabolism*; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D008171:Lung Diseases / Q000378:metabolism / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism*; D011653:Pulmonary Diffusing Capacity / Q000379:methods* / Q000592:standards; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012015:Reference Standards; D014655:Vascular Resistance
chemical_list: D009569:Nitric Oxide; D002248:Carbon Monoxide
keywords: Carbon monoxide; Diffusion pulmonaire; Lung diffusion; Monoxyde de carbone; Monoxyde d’azote; Nitric oxide