title: Natural infection of Burkholderia pseudomallei in an imported pigtail macaque (Macaca nemestrina) and management of the exposed colony.
abstract: Identification of the select agent Burkholderia pseudomallei in macaques imported into the United States is rare. A purpose-bred, 4.5-y-old pigtail macaque (Macaca nemestrina) imported from Southeast Asia was received from a commercial vendor at our facility in March 2012. After the initial acclimation period of 5 to 7 d, physical examination of the macaque revealed a subcutaneous abscess that surrounded the right stifle joint. The wound was treated and resolved over 3 mo. In August 2012, 2 mo after the stifle joint wound resolved, the macaque exhibited neurologic clinical signs. Postmortem microbiologic analysis revealed that the macaque was infected with B. pseudomallei. This case report describes the clinical evaluation of a B. pseudomallei-infected macaque, management and care of the potentially exposed colony of animals, and protocols established for the animal care staff that worked with the infected macaque and potentially exposed colony. This article also provides relevant information on addressing matters related to regulatory issues and risk management of potentially exposed animals and animal care staff.
authors: National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Animal Resources Branch, Atlanta, Georgia, USA; Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mt Sinai, New York, New York, USA.
authors: Crystal H
authors: CH
authors: Johnson
authors: Brianna L
authors: BL
authors: Skinner
authors: Sharon M
authors: SM
authors: Dietz
authors: David
authors: D
authors: Blaney
authors: Robyn M
authors: RM
authors: Engel
authors: George W
authors: GW
authors: Lathrop
authors: Alex R
authors: AR
authors: Hoffmaster
authors: Jay E
authors: JE
authors: Gee
authors: Mindy G
authors: MG
authors: Elrod
authors: Nathaniel
authors: N
authors: Powell
authors: Henry
authors: H
authors: Walke
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D019121:Burkholderia Infections / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology; D016957:Burkholderia pseudomallei / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D008254:Macaca nemestrina; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents