title: Acute coronary syndromes are associated with a reduction of VLA-1+ peripheral blood T cells and their enrichment in coronary artery plaque aspirates.
abstract: Memory T cells producing interferon (IFN)γ and expressing very late antigen-1 (VLA-1) integrin collagen receptors are found in carotid atherosclerotic plaques, suggesting their involvement in coronary artery disease (CAD) as well. To determine the role of VLA-1+ T cells in CAD percent of CD3+ T cells binding monoclonal antibodies (mAb) to VLA-1 in peripheral blood (PB), and in coronary plaque material aspirated during coronary arterography and arterial blood, were analyzed in a cohort of 117 patients with CAD and 34 controls without CAD. % VLA-1+ T cells in PB was 0.63 ± 0.09% in controls compared to 0.96 ± 0.95% in patients with CAD (p<0.009). The increase was due to a marked elevation of % VLA-1+ T cells in stable CAD (1.6 ± 0.27%) whereas % VLA-1+ T cells during acute coronary syndromes (ACS) and in patients with ischemia by thalium SPECT scan had significantly lower levels. % VLA-1+ T cells in coronary artery plaque material aspirated during therapeutic angiography in patients with ACS was significantly higher than in arterial blood (1.39 ± 0.96% vs 0.75 ± 0.84%, p<0.035, n=3). Thus, % VLA-1+ T cells increases in the PB during stable CAD but decreases in ACS. The finding of their enrichment in coronary blood containing atherosclerotic plaque aspirates suggests that a shift of VLA-1+ T cells from blood to atherosclerotic plaques may play a role in plaque instability in patients with ACS.
authors: Department of Internal Medicine, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Arik
authors: A
authors: Asman
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Pierre
authors: P
authors: Chouraqui
authors: Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Victoria
authors: V
authors: Marcu-Malina
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Shlomo
authors: S
authors: Matetzky
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Amit
authors: A
authors: Segev
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Paul
authors: P
authors: Fefer
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Oren
authors: O
authors: Agranat
authors: Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Alexander
authors: A
authors: Koltakov
authors: Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Hanoch
authors: H
authors: Hod
authors: Department of Internal Medicine, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Avi
authors: A
authors: Livneh
authors: Department of Internal Medicine, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: ibank@post.tau.ac.il.
authors: Ilan
authors: I
authors: Bank
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000276:immunology*; D000792:Angiography; D001775:Blood Circulation / Q000276:immunology*; D002465:Cell Movement; D002469:Cell Separation; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D039222:Integrin alpha1beta1 / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D058226:Plaque, Atherosclerotic / Q000276:immunology; D013601:T-Lymphocytes / Q000000981:diagnostic imaging / Q000276:immunology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D039222:Integrin alpha1beta1
keywords: Alpha1beta1 integrin; Atherosclerosis; Coronary artery disease; Integrin; T cells; VLA-1