title: Poly(N-vinyl caprolactam) grown on nanographene oxide as an effective nanocargo for drug delivery.
abstract: This study evaluated graphene oxide functionalized covalently with poly N-vinyl caprolactam (GO-PVCL) via in situ atomic transfer radical polymerization (ATRP), as a nano-cargo carrier for the efficient delivery of drugs into cells. Water-soluble GO-PVCL exhibited excellent stability in physiological solutions. An anti-cancer drug, camptothecin (CPT), was then loaded onto GO-PVCL with a high payload (20%) through π-π stacking and hydrophobic interactions, and its release could be controlled by varying the pH. PVCL grafted onto GO offers an additional advantage of targeted delivery according to temperature. GO-PVCL showed no obvious toxicity, whereas the CPT-loaded GO-PVCL showed high potency in killing cancer cells in vitro. The drug transportation mechanism was found to be energy-dependent endocytosis. Overall, this study revealed GO-PVCL to be a promising drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, and good payload capacity owing to its small size, low cost, large specific area, ready scalability, and useful non-covalent interactions. This material is expected to be a novel material propitious for biomedical applications.
authors: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Thangavelu
authors: T
authors: Kavitha
authors: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Inn-Kyu
authors: IK
authors: Kang
authors: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea. Electronic address: psy@knu.ac.kr.
authors: Soo-Young
authors: SY
authors: Park
mesh_terms: D002166:Camptothecin / Q000494:pharmacology; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006108:Graphite / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012542:Scattering, Radiation; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D004337:Drug Carriers; D010087:Oxides; D011108:Polymers; C086861:poly-N-vinylcaprolactam; D002209:Caprolactam; D006108:Graphite; D002166:Camptothecin
keywords: Biocompatible; Graphene oxide; Molecular weight dependent LCST; Nanocargo; Poly(N-vinyl caprolactam)