title: An elucidation of neutrophil functions against Mycobacterium tuberculosis infection.
abstract: We characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M. tb) infection, with particular reference to glutathione (GSH). We examined the effects of GSH in improving the ability of neutrophils to control intracellular M. tb infection. Our findings indicate that increasing the intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted in reduction in the levels of free radicals and increased acidification of M. tb containing phagosomes leading to the inhibition in the growth of M. tb. This inhibitory mechanism is dependent on the presence of TNF-α and IL-6. Our studies demonstrate a novel regulatory mechanism adapted by the neutrophils to control M. tb infection.
authors: College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
authors: Devin
authors: D
authors: Morris
authors: Thien
authors: T
authors: Nguyen
authors: John
authors: J
authors: Kim
authors: Christine
authors: C
authors: Kassissa
authors: Melissa
authors: M
authors: Khurasany
authors: Jennifer
authors: J
authors: Luong
authors: Sarah
authors: S
authors: Kasko
authors: Shalin
authors: S
authors: Pandya
authors: Michael
authors: M
authors: Chu
authors: Po-Ting
authors: PT
authors: Chi
authors: Judy
authors: J
authors: Ly
authors: Minette
authors: M
authors: Lagman
authors: Vishwanath
authors: V
authors: Venketaraman
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D005609:Free Radicals; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D005978:Glutathione; D000111:Acetylcysteine