title: Distribution of breast cancer subtypes among Jordanian women and correlation with histopathological grade: molecular subclassification study.
abstract: OBJECTIVE
  To evaluate the hormone receptor status and human epidermal growth factor receptor 2 (HER2)/neu gene expression among Jordanian women with breast cancer. To classify our patients into molecular subtypes and to correlate the results with age of the patients and tumour grade.
  
  
  METHODS
  Evaluation of estrogen receptor (ER), PR and HER2/neu was done by standard immunohistochemical technique and subclassification into molecular subtypes.
  
  
  METHODS
  Jordan University Hospital, Amman, Jordan.
  
  
  METHODS
  One hundred and ninety-three cases of breast cancer diagnosed at Jordan University Hospital.
  
  
  METHODS
  Molecular subtypes of breast cancer, age and tumour grade.
  
  
  RESULTS
  ALL THE CASES WERE DIVIDED INTO TWO GROUPS: the young age group less or equal 50 years of age and the older age group more than 50 years of age. The cases were subclassified into luminal A, luminal B, basal cell like (BCL) and Her2/neu+. In older age group, the most common subtype was luminal A (72%). In this age group, most of the cases (48%) were of grade II. In younger age group, 47% of the cases were of luminal A subclass. In this age group, 42% were of grade I.
  
  
  CONCLUSIONS
  Molecular subtyping of breast cancer is an essential predicting factor of tumour response to hormonal therapy. This fact puts increased stress on the urgent need for the development of reliable and reproducible classification systems.
authors: Department of Histopathology, Jordan University Hospital, Amman, 11942, Jordan.
authors: Maha
authors: M
authors: Shomaf
authors: Jamal
authors: J
authors: Masad
authors: Saleh
authors: S
authors: Najjar
authors: Dana
authors: D
authors: Faydi