title: Multimodal evaluation of macular function in age-related macular degeneration.
abstract: OBJECTIVE
  To evaluate macular function using multimodality in eyes with age-related macular degeneration (AMD) at various stages.
  
  
  METHODS
  Macular function in 20 control eyes (20 subjects), 17 eyes (17 patients) with large drusen, 18 eyes (18 patients) with drusenoid pigment epithelial detachment (PED), and 19 eyes (19 patients) with neovascular AMD was examined using a Landolt chart for visual acuity; retinal sensitivity was measured by microperimetry; and focal macular electroretinography (fmERG) was performed. In all of these eyes, retinal morphology was examined using optical coherence tomography.
  
  
  RESULTS
  Eyes with neovascular AMD showed morphologic changes in the neurosensory retina as well as marked deterioration of macular function in all parameters measured with a Landolt chart, fmERG, and microperimetry. Eyes with large drusen showed only minimal morphologic changes in the neurosensory retina. In this large drusen group, although retinal sensitivity at the central point was significantly decreased (P = 0.0063), the other parameters of macular function were well preserved. In eyes with drusenoid PED, the structure of the neurosensory retina was well preserved, while the foveal thickness was significantly increased (P = 0.013). The macular function of these eyes was significantly deteriorated, with the VA, amplitude of the a-wave and b-wave, and retinal sensitivity being markedly decreased. In addition, the area of PED correlated with the latency of the a-wave and b-wave and with the retinal sensitivity within the central 4° or 8° region.
  
  
  CONCLUSIONS
  Multimodal evaluation demonstrated a significant decrease in macular function in drusenoid PED and in neovascular AMD.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.
authors: Ken
authors: K
authors: Ogino
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Kenji
authors: K
authors: Yamashiro
authors: Sotaro
authors: S
authors: Ooto
authors: Akio
authors: A
authors: Oishi
authors: Isao
authors: I
authors: Nakata
authors: Masahiro
authors: M
authors: Miyake
authors: Ayako
authors: A
authors: Takahashi
authors: Abdallah A
authors: AA
authors: Ellabban
authors: Nagahisa
authors: N
authors: Yoshimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D057092:Geographic Atrophy / Q000503:physiopathology*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D064847:Multimodal Imaging; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D057135:Wet Macular Degeneration / Q000503:physiopathology*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green