title: Differential equations with applications in cancer diseases.
abstract: Mathematical modeling is a process by which a real world problem is described by a mathematical formulation. The cancer modeling is a highly challenging problem at the frontier of applied mathematics. A variety of modeling strategies have been developed, each focusing on one or more aspects of cancer.
  
  
  METHODS
  The vast majority of mathematical models in cancer diseases biology are formulated in terms of differential equations. We propose an original mathematical model with small parameter for the interactions between these two cancer cell sub-populations and the mathematical model of a vascular tumor. We work on the assumption that, the quiescent cells' nutrient consumption is long. One the equations system includes small parameter epsilon. The smallness of epsilon is relative to the size of the solution domain.
  
  
  RESULTS
  MATLAB simulations obtained for transition rate from the quiescent cells' nutrient consumption is long, we show a similar asymptotic behavior for two solutions of the perturbed problem. In this system, the small parameter is an asymptotic variable, different from the independent variable. The graphical output for a mathematical model of a vascular tumor shows the differences in the evolution of the tumor populations of proliferating, quiescent and necrotic cells. The nutrient concentration decreases sharply through the viable rim and tends to a constant level in the core due to the nearly complete necrosis in this region.
  
  
  CONCLUSIONS
  Many mathematical models can be quantitatively characterized by ordinary differential equations or partial differential equations. The use of MATLAB in this article illustrates the important role of informatics in research in mathematical modeling. The study of avascular tumor growth cells is an exciting and important topic in cancer research and will profit considerably from theoretical input. Interpret these results to be a permanent collaboration between math's and medical oncologists.
authors: Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi.
authors: M
authors: M
authors: Ilea
authors: M
authors: M
authors: Turnea
authors: M
authors: M
authors: Rotariu
mesh_terms: D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological; D008962:Models, Theoretical; D009336:Necrosis; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D013997:Time Factors; D019043:Vascular Neoplasms / Q000473:pathology