title: Trapa natans L. root extract suppresses hyperglycemic and hepatotoxic effects in STZ-induced diabetic rat model.
abstract: BACKGROUND
  Trapa natans L. has a folkloric reputation as nutrient, appetizer and astringent. Its utility as antidiabetic, anticancer, diuretic, aphrodisiac, antidiarrhoeal and in many other maladies is well reported in the literature. Therefore, the present study has been carried out to study the antihyperglycemic effect of root extract of Trapa natans L. and its various fractions. Furthermore, hepatotoxic effects and lipid peroxidation risks have also been evaluated.
  
  
  METHODS
  The ethanol extract and its successive fractions obtained from roots of Trapa natans have been administered in sucrose loaded and STZ- induced diabetic Wistar rats at doses of 50, 100 and 200mg/kg b.w. Glibenclamide was used as positive control. The evaluation of protective effects of extract as well as fractions against hepatotoxicity and lipid peroxidation at 600mg/kg b.w. has also been carried out.
  
  
  RESULTS
  The methanol fraction emerged as the most potent antihyperglycemic fraction. It has also been found that the ethanolic extract as well as its fractions did not cause any lipid peroxidation and hepatotoxicity risks.
  
  
  CONCLUSIONS
  It can be concluded that the intense investigations of the methanol fraction obtained from Trapa natans root extract can be done to provide an alternative natural therapy for hyperglycemia.
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Chetna
authors: C
authors: Kharbanda
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India. Electronic address: msalam@jamiahamdard.ac.in.
authors: Mohammad
authors: M
authors: Sarwar Alam
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Hinna
authors: H
authors: Hamid
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Sameena
authors: S
authors: Bano
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Saqlain
authors: S
authors: Haider
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Syed
authors: S
authors: Nazreen
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Yakub
authors: Y
authors: Ali
authors: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.
authors: Kalim
authors: K
authors: Javed
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D029561:Lythraceae; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020011:Protective Agents
keywords: Antihyperglycemic; Hepatotoxic; Lipid peroxidation; RP-HPLC; Trapa natans L.