title: Evaluation of trace elements, oxidant/antioxidant status, vitamin C and β-carotene in dogs with dermatophytosis.
abstract: The aim of the study was to determine zinc, copper and iron levels, erythrocyte oxidant/antioxidant status, vitamin C and β-carotene in dogs with dermatophytosis. A total of 23 dogs with clinically established diagnosis of dermatophytosis by trichogram and positive fungal culture and six dogs as control were included in this study. On cultural examination 52.17% fungal isolates were found to be Microsporum canis, 30.43% were Trichophyton mentagrophytes and 17.39% were M. gypseum. In comparison to healthy control, the dogs with dermatophytosis had significantly lower levels of zinc (P < 0.01), copper (P < 0.05), β-carotene and vitamin C levels (P < 0.05) and activities of superoxide dismutase (SOD) (P < 0.05) and catalase (P < 0.01), whereas the iron (P < 0.05) and malondialdehyde (MDA) (P < 0.01) levels were significantly increased. On correlation analysis, SOD activity was observed to be positively correlated (P < 0.05) with zinc and copper in both healthy and dermatophytosis affected dogs. In dermatophytosis affected dogs the MDA levels were negatively correlated (P < 0.05) with iron, β-carotene levels and the activities of antioxidant enzymes; SOD and catalase. Our results demonstrated that dermatophytosis in dogs is associated with significant alteration in oxidant/antioxidant balance and trace elements. It might be secondary consequence of dermatophytosis infection or contributing factor in its pathogenesis.
authors: Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu (J & K), India.
authors: S A
authors: SA
authors: Beigh
authors: J S
authors: JS
authors: Soodan
authors: R
authors: R
authors: Singh
authors: A M
authors: AM
authors: Khan
authors: M A
authors: MA
authors: Dar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D003883:Arthrodermataceae / Q000145:classification / Q000302:isolation & purification*; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology*; D004285:Dogs; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D008297:Male; D008864:Microsporum / Q000302:isolation & purification; D016877:Oxidants / Q000097:blood*; D014005:Tinea / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D014131:Trace Elements / Q000097:blood*; D014249:Trichophyton / Q000302:isolation & purification; D014815:Vitamins / Q000097:blood*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D014131:Trace Elements; D014815:Vitamins
keywords: Antioxidants; copper; dermatophytosis; iron; oxidants; vitamin C and zinc; β-carotene