title: Inducing cellular aging: enabling neurodegeneration-in-a-dish.
abstract: The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.
authors: Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address: kristen.brennand@mssm.edu.
authors: Kristen J
authors: KJ
authors: Brennand
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D034904:Lamin Type A; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*
chemical_list: D034904:Lamin Type A; D009687:Nuclear Proteins; D011498:Protein Precursors; C090764:prelamin A