title: Retracted: FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  This article has been retracted at the request of the authors.
  
  This study provided an explanation for why loss of FoxP3 in inducible regulatory T cells results in reduced expression of interleukin (IL)-10 despite the absence of FoxP3 binding sites in the IL-10 promoter. STAT3 binding sites do exist in the promoter, and evidence for a direct molecular interaction between FoxP3 and STAT3 proteins was provided as an explanation of the effect of loss of FoxP3. As supporting evidence, we reported modeling of a structural interaction between these two transcription factors in Figure 4D. As the N-terminal region of FoxP3, which consists of the Exon-2 region, had not been solved at structural resolution, we mistakenly used what we deduced to be a FoxP3 related transcription factor, NFAT, in the modeling. The model depicted in Figure 4D therefore did not represent a putative interaction between FoxP3 and STAT3 as labeled, but rather a putative interaction between NFAT and STAT3. Given the incorrect labeling of Figure 4D, the lack of documentation in the paper describing exactly how the modeling was performed, the lack of evidence shown in the paper for the choice of NFAT as the modeling partner, and the limited supporting evidence for a cooperative interaction between FoxP3 and STAT3, the editors have concluded with the corresponding author that the appropriate course of action is to retract the paper. We apologize for any confusion and inconvenience caused to readers.
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Dewan Md Sakib
authors: DM
authors: Hossain
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Abir K
authors: AK
authors: Panda
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Argha
authors: A
authors: Manna
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Suchismita
authors: S
authors: Mohanty
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Pushpak
authors: P
authors: Bhattacharjee
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Sankar
authors: S
authors: Bhattacharyya
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Taniya
authors: T
authors: Saha
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Sreeparna
authors: S
authors: Chakraborty
authors: Department of Biophysics, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Rajiv K
authors: RK
authors: Kar
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Tanya
authors: T
authors: Das
authors: Department of Biophysics, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors: Subhrangsu
authors: S
authors: Chatterjee
authors: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India. Electronic address: gauri@jcbose.ac.in.
authors: Gaurisankar
authors: G
authors: Sa
mesh_terms: D001943:Breast Neoplasms / Q000503:physiopathology*; D045744:Cell Line, Tumor; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008958:Models, Molecular; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D050796:STAT3 Transcription Factor; D014157:Transcription Factors