title: Fly model causes neurological rethink.
abstract: A Drosophila model for a neurological disorder called type 2B Charcot-Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for a new therapeutic approach.
authors: Madhumala K
authors: MK
authors: Sadanandappa
authors: Madhumala K Sadanandappa is in the National Centre for Biological Sciences-TIFR, Bangalore, India madhumala@ncbs.res.in.
authors: Madhumala K
authors: MK
authors: Sadandappa
authors: Mani
authors: M
authors: Ramaswami
mesh_terms: D000818:Animals; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D000083083:Laminopathies; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics*; D020691:rab GTP-Binding Proteins / Q000235:genetics*; D000090802:rab7 GTP-Binding Proteins
chemical_list: D000090802:rab7 GTP-Binding Proteins; D020691:rab GTP-Binding Proteins
keywords: animal models of disease; endosome; genetics; neuropathy; synapse