title: Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation.
abstract: Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor‑derived epithelial cells but also donor-derived secondary solid tumors have also been reported in mice and humans. It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. In most reports of donor-derived secondary solid tumors, however, tumors contained a low proportion of BMDC-derived epithelial cells in mixed solid tumor tissues. To our knowledge, there are only five known cases of completely donor-derived tumor tissues, i.e., four oral SCCs and a pharyngeal SCC. In this study, we analyzed five human clinical samples of solid tumors, i.e., two esophageal squamous cell carcinomas (SCCs), two oral SCCs and a tongue carcinoma. In the oral and tongue, completely donor-derived tissues were not observed, but in esophagus a completely donor-derived esophageal epidermis and SCC were observed for the first time. In addition, in another esophageal SCC patient, a completely donor-derived dysplasia region of esophageal epidermis was observed near recipient-derived SCC. This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Yoshihiro
authors: Y
authors: Kano
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Hideshi
authors: H
authors: Ishii
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Masamitsu
authors: M
authors: Konno
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Makoto
authors: M
authors: Yamasaki
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Hiroshi
authors: H
authors: Miyata
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Shimpei
authors: S
authors: Nishikawa
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Atsushi
authors: A
authors: Hamabe
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Hisataka
authors: H
authors: Ogawa
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Hidekazu
authors: H
authors: Takahashi
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Katsuya
authors: K
authors: Ohta
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Shinichiro
authors: S
authors: Hasegawa
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Kouji
authors: K
authors: Tanaka
authors: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Takahito
authors: T
authors: Fukusumi
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Masahisa
authors: M
authors: Otsuka
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Koichi
authors: K
authors: Kawamoto
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Naotsugu
authors: N
authors: Haraguchi
authors: Laboratory of Molecular and Cellular Biology, Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Toyama, Japan.
authors: Rika
authors: R
authors: Fujimoto
authors: Laboratory of Molecular and Cellular Biology, Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Toyama, Japan.
authors: Masaharu
authors: M
authors: Isobe
authors: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors: Yasuhiko
authors: Y
authors: Tomita
authors: Department of Functional Diagnostic Science, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Nariaki
authors: N
authors: Matsuura
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Shuji
authors: S
authors: Takiguchi
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Masaki
authors: M
authors: Mori
authors: Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Yuichiro
authors: Y
authors: Doki
mesh_terms: D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000473:pathology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D019070:Cell Lineage; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics; D004817:Epidermis / Q000473:pathology*; D004848:Epithelium / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014062:Tongue Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy