title: Direct functionalization of unactivated C-H bonds catalyzed by group 3-5 metal alkyl complexes.
abstract: This perspective summarizes direct C-H bond functionalization reactions catalyzed by group 3-5 metal alkyl complexes. Metal-carbon bonds of group 3-5 metals have potentially high reactivity toward both C-H bond activation reactions through the intrinsic σ-bond metathesis pathway and insertion of unsaturated organic molecules. Upon the combination of these two elemental steps, direct C-H bond functionalization reactions of (hetero)aromatic compounds, methane, alkylamines, and terminal alkynes, proceed through C(sp)-H, C(sp(2))-H, and C(sp(3))-H bond activation reactions. Here we review as catalysts for these transformations not only simple metallocene complexes but also non-metallocene complexes supported by a variety of ligands, which are often superior in terms of catalyst design and catalytic activity.
authors: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan. mashima@chem.es.osaka-u.ac.jp.
authors: Hayato
authors: H
authors: Tsurugi
authors: Koji
authors: K
authors: Yamamoto
authors: Haruki
authors: H
authors: Nagae
authors: Hiroshi
authors: H
authors: Kaneko
authors: Kazushi
authors: K
authors: Mashima