title: Comparison of wide-field fluorescein angiography and 9-field montage angiography in uveitis.
abstract: OBJECTIVE
  To compare qualitatively and quantitatively Optos fundus camera fluorescein angiographic images of retinal vascular leakage with 9-field montage Topcon fluorescein angiography (FA) images in patients with uveitis. We hypothesized that Optos images reveal more leakage in patients with uveitis.
  
  
  METHODS
  Retrospective, observational case series.
  
  
  METHODS
  Images of all patients with uveitis imaged with same-sitting Optos FA and 9-field montage FA during a 9-month period at a single institution (52 eyes of 31 patients) were graded for the total area of retinal vascular leakage. The main outcome measure was area of fluorescein leakage.
  
  
  RESULTS
  The area of apparent FA leakage was greater in Optos images than in 9-field montage images (median 22.5 mm(2) vs 4.8 mm(2), P < 0.0001). Of the 49 (45%) eyes with gradable photos, 22 had at least 25% more leakage in the Optos image than in the montage image; 2 (4.1%) had at least 25% less leakage in Optos; and 25 (51%) were similar in the 2 modalities. There were 2 eyes that had no apparent retinal vascular leakage in 9-field montage but were found to have apparent leakage in Optos images. Of the 49 eyes, 23 had posterior pole leakage, and of these, 17 (73.9%) showed more posterior pole leakage in the Optos image. A single 200-degree Optos FA image captured a mean 1.50× the area captured by montage photography.
  
  
  CONCLUSIONS
  More retinal vascular pathology, in both the periphery and the posterior pole, is seen with Optos FA in patients with uveitis when compared with 9-field montage. The clinical implications of Optos FA findings have yet to be determined.
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Benjamin P
authors: BP
authors: Nicholson
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Divya
authors: D
authors: Nigam
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Darby
authors: D
authors: Miller
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Elvira
authors: E
authors: Agrón
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Monica
authors: M
authors: Dalal
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Naima
authors: N
authors: Jacobs-El
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Breno
authors: B
authors: da Rocha Lima
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Denise
authors: D
authors: Cunningham
authors: National Eye Institute, National Institutes of Health, Bethesda, MD.
authors: Robert
authors: R
authors: Nussenblatt
authors: National Eye Institute, National Institutes of Health, Bethesda, MD. Electronic address: senh@nei.nih.gov.
authors: H Nida
authors: HN
authors: Sen
mesh_terms: D000293:Adolescent; D000328:Adult; D002199:Capillary Permeability; D002648:Child; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*; D012189:Retrospective Studies; D015866:Uveitis, Posterior / Q000175:diagnosis*; D055815:Young Adult