title: An experience with paediatric burn wounds treated with a plant-derived wound therapeutic.
abstract: OBJECTIVE
  To observe the efficacy of a plant-derived wound dressing (1 Primary Wound Dressing®), a mixture of hypericum and neem oil, in different types of paediatric burns.
  
  
  METHODS
  A retrospective review was conducted over the complete healing course of 9 paediatric patients with a mean age of 8.17±3.35 (1-11 years), presenting mixed, partial or full-thickness burns. The treatment applied by the wound care specialist consisted of daily cleansing of the wound with a saline solution and application of 1 Primary Wound Dressing on the whole wound surface. There was no application of a secondary dressing. The time to heal, wound size, ease of handling, pain and complications were recorded. Procedural and background pain were observed in six of the patients older than 5 years (mean age 9.6±2.39, range 8-11 years). Due to the small number of patients examined during the period studied, it was not possible to perform statistical analyses.
  
  
  RESULTS
  The mean wound size was 50.76±48.32cm2 (4.63-132.0cm2). A rapid induction of granulation tissue and re-epithelialisation was observed. Time to complete healing was 16.6±4.69 days (10-22 days). No complications related to wound infection was observed. The 6 patients older than five years reported a strong relief of pain, from an initial value of 7-8 out of 10 to 0 out of 10 within the first week of treatment. This remained at the 0 out of 10 level during the second and third weeks of treatment.
  
  
  CONCLUSIONS
  This retrospective, non-controlled examination suggests that 1 Primary Wound Dressing could be an effective therapy for the treatment of burn wounds, with benefits including pain reduction and simplicity of use. Further evaluations with a larger population are required to document the effectiveness of this plant-derived wound dressing in a controlled fashion.
  
  
  BACKGROUND
  There were no external sources of funding for this study. F. Carnevali is a researcher and co-inventor of 1 Primary Wound Dressing®.
authors: DM Specialist in Anesthesiology and Emergency Medicine, Santo Spirito Hospital, Rome, Italy.
authors: S
authors: S
authors: Mainetti
authors: DVM Researcher, ENEA Casaccia Research Centre, Rome, Italy.
authors: F
authors: F
authors: Carnevali
mesh_terms: D031601:Azadirachta / Q000737:chemistry; D001838:Bolivia; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005989:Glycerides / Q000032:analysis / Q000627:therapeutic use*; D006801:Humans; D020902:Hypericum / Q000737:chemistry; D007223:Infant; D008297:Male; D009779:Occlusive Dressings; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D012189:Retrospective Studies; D013729:Terpenes / Q000032:analysis / Q000627:therapeutic use*; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005989:Glycerides; D010936:Plant Extracts; D013729:Terpenes; C002443:neem oil