title: Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol.
abstract: Circadian rhythms are a prominent and critical feature of cells, tissues, organs, and behavior that help an organism function most efficiently and anticipate things such as food availability. Therefore, it is not surprising that disrupted circadian rhythmicity, a prominent feature of modern-day society, promotes the development and/or progression of a wide variety of diseases, including inflammatory, metabolic, and alcohol-associated disorders. This article will discuss the influence of interplay between alcohol consumption and circadian rhythmicity and how circadian rhythm disruption affects immune function and metabolism as well as potential epigenetic mechanisms that may be contributing to this phenomenon.
authors: Rush University Medical Center, Chicago, Illinois, USA.
authors: Robin M
authors: RM
authors: Voigt
authors: Christopher B
authors: CB
authors: Forsyth
authors: Ali
authors: A
authors: Keshavarzian
mesh_terms: D019973:Alcohol-Related Disorders / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D021081:Chronobiology Disorders / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol