title: Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis.
abstract: We report a case of a 55-year-old immunocompromised female who presented to the emergency department with severe diarrhea and vomiting following travel to the Philippines. Stool bacteriology revealed a mixed infection involving an enteropathogenic Escherichia coli and two distinct strains of enteroaggregative Escherichia coli (EAEC). During hospitalization, urine and blood culture tested positive for one of the diarrheagenic EAEC strains, necessitating urinary catheterization, intensive care, and antimicrobial treatment with trimethoprim-sulfamethoxazole, followed by meropenem. Although known to occasionally cause urinary tract infections, EAEC have not been previously associated with sepsis. Our report highlights the potential of EAEC to cause severe extraintestinal infections.
authors: Institute of Laboratory Medicine, Cantonal Hospital Frauenfeld, 8501, Frauenfeld, Switzerland.
authors: K
authors: K
authors: Herzog
authors: J
authors: J
authors: Engeler Dusel
authors: M
authors: M
authors: Hugentobler
authors: L
authors: L
authors: Beutin
authors: G
authors: G
authors: Sägesser
authors: R
authors: R
authors: Stephan
authors: H
authors: H
authors: Hächler
authors: M
authors: M
authors: Nüesch-Inderbinen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000628:therapy; D003422:Critical Care; D003967:Diarrhea / Q000382:microbiology / Q000628:therapy; D054308:Enteropathogenic Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010679:Philippines; D018805:Sepsis / Q000382:microbiology* / Q000628:therapy; D014195:Travel; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000150:complications* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination