title: Anti-hepatoma activity and mechanism of corn silk polysaccharides in H22 tumor-bearing mice.
abstract: Corn silk is a well known traditional Chinese herbal medicine and corn silk polysaccharides (CSP) possess multiple pharmacological activities. However, the antitumor effect of CSP on hepatocarcinoma has not been studied. This study aimed to investigate the effects of CSP on tumor growth and immune functions in H22 hepatocarcinoma tumor-bearing mice. The results demonstrated that CSP could not only inhibit the tumor growth, but also extended the survival time of H22 tumor-bearing mice. Besides, CSP administration could increase the body weight, peripheral white blood cells (WBC) count, thymus index and spleen index of H22 tumor-bearing mice. Furthermore, the production of serum cytokines in H22 tumor-bearing mice, such as IL-2, IL-6 and TNF-α, was enhanced by CSP treatment. In addition, no toxicological effects were observed on hepatic function and renal function in CSP-treated mice transplanted H22 tumor cells. In summary, this experimental finding indicated that CSP could elevate the immune functions in H22 tumor-bearing mice to enhance its antitumor activity and CSP seems to be a safe and effective agent for the treatment of hepatocellular carcinoma.
authors: Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Jingyue
authors: J
authors: Yang
authors: Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
authors: Xiao
authors: X
authors: Li
authors: Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Yan
authors: Y
authors: Xue
authors: Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Electronic address: wangnanemail@126.com.
authors: Nan
authors: N
authors: Wang
authors: Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: wench_liu@126.com.
authors: Wenchao
authors: W
authors: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D047368:Tumor Burden / Q000187:drug effects; D003313:Zea mays / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016207:Cytokines; D011134:Polysaccharides
keywords: Anti-hepatoma activity; Corn silk polysaccharides; Immunomodulation