title: Biomaterials and design in occlusion devices for cardiac defects: a review.
abstract: This review examines the biomaterials used in occlusion devices for cardiac defects, and how the choice of these materials is dictated by design. Specifically, the devices used in three major applications, the atrial septal defect, the ventricular septal defect and the patent ductus arteriosus, are examined critically. A number of different devices are available, with varied performance in deployment and sealing. There is no device in any of the three categories that satisfies fully the range of requirements, and all have associated complications. The type and rate of complications are different among different devices. The short-term (immediate) complications are addressed by immediate retrieval. For longer-term complications, most of which can be fatal, currently only surgical retrieval and replacement are possible. Most of these longer-term complications can be alleviated by the use of fully degradable devices, which will eliminate concerns regarding the use of metals inside the heart, and if fully endothelialized, also minimize migration concerns. On the other hand, the lower moduli of currently available biodegradable materials need to be augmented. Improvements in the stiffness required for deployment can be accomplished with the use of fillers, nano- or micro-sized, and an example of this are radiopaque fillers.
authors: School of Materials Science and Engineering, Nanyang Technological University, Singapore S639798, Singapore.
authors: Yingying
authors: Y
authors: Huang
authors: School of Materials Science and Engineering, Nanyang Technological University, Singapore S639798, Singapore.
authors: Jen Fong
authors: JF
authors: Kong
authors: School of Materials Science and Engineering, Nanyang Technological University, Singapore S639798, Singapore. Electronic address: assubbu@ntu.edu.sg.
authors: Subbu S
authors: SS
authors: Venkatraman
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D001807:Blood Vessel Prosthesis; D006083:Graft Occlusion, Vascular / Q000628:therapy*; D006330:Heart Defects, Congenital / Q000628:therapy*; D006801:Humans; D011474:Prosthesis Design
chemical_list: D001672:Biocompatible Materials
keywords: Atrial septal defect; Biomaterials; Occlusion device; Patent ductus arteriosus; Ventricular septal defect