title: Canalicular adenoma immunoprofile: a case report.
abstract: OBJECTIVE
  To report a case of canalicular adenoma (CA) and discuss the use of immunohistochemistry to better address the diagnosis given some unusual characteristics in this patient.
  
  
  BACKGROUND
  CA is an uncommon benign neoplasm that can develop in minor salivary gland duct tissues throughout the oral cavity. At histology, it shares several features with other salivary tumors. Immunohistochemistry can be useful in the differential diagnosis.
  
  
  METHODS
  The clinical presentation consisted in a nodule on the left upper lip of an 85-year-old man. The patient's main complaint was upper denture instability secondary to soft tissue changes. The nodule was excised under local anesthesia and underwent histological and immunohistochemical examination to rule out any malignancy.
  
  
  RESULTS
  Histological findings, cytokeratin positivity and the absence of any reactivity to specific markers of myoepithelial differentiation confirmed the epithelial nature of the lesion.
  
  
  CONCLUSIONS
  The histological diagnosis of benign salivary tumors such as CA can be confirmed by immunohistochemistry.
authors: Institute of Clinical Dentistry, Department of Neurosciences, Neurological, Psychiatric, Sensorial, Reconstructive and Rehabilitative Sciences, University of Padova, Padova, Italy.
authors: Stefano
authors: S
authors: Sivolella
authors: Marialuisa
authors: M
authors: Valente
authors: Marleen
authors: M
authors: De Biagi
authors: Sergio
authors: S
authors: Mazzoleni
authors: Edoardo
authors: E
authors: Stellini
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000175:diagnosis*; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D008048:Lip Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008297:Male; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology*
chemical_list: D053552:Keratin-7
keywords: benign tumor; canalicular adenoma; immunohistochemistry; salivary glands