title: Graphene oxide based theranostic platform for T1-weighted magnetic resonance imaging and drug delivery.
abstract: Magnetic resonance imaging (MRI) is a powerful and widely used clinical technique in cancer diagnosis. MRI contrast agents (CAs) are often used to improve the quality of MRI-based diagnosis. In this work, we developed a positive T1 MRI CA based on graphene oxide (GO)-gadolinium (Gd) complexes. In our strategy, diethylenetriaminepentaacetic acid (DTPA) is chemically conjugated to GO, followed by Gd(III) complexation, to form a T1 MRI CA (GO-DTPA-Gd). We have demonstrated that the GO-DTPA-Gd system significantly improves MRI T1 relaxivity and leads to a better cellular MRI contrast effect than Magnevist, a commercially used CA. Next, an anticancer drug, doxorubicin (DOX), was loaded on the surface of GO sheets via physisorption. Thus-prepared GO-DTPA-Gd/DOX shows significant cytotoxicity to the cancer cells (HepG2). This work provides a novel strategy to build a GO-based theranostic nanoplatform with T1-weighted MRI, fluorescence imaging, and drug delivery functionalities.
authors: Suzhou Key Laboratory of Nanobiomedicine, Division of Nanobiomedicine, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences , 398 Ruoshui Road, Suzhou 215123, China.
authors: Mengxin
authors: M
authors: Zhang
authors: Yuhua
authors: Y
authors: Cao
authors: Yu
authors: Y
authors: Chong
authors: Yufei
authors: Y
authors: Ma
authors: Hailu
authors: H
authors: Zhang
authors: Zongwu
authors: Z
authors: Deng
authors: Chunhong
authors: C
authors: Hu
authors: Zhijun
authors: Z
authors: Zhang
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D003952:Diagnostic Imaging; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005682:Gadolinium / Q000737:chemistry; D006108:Graphite / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010087:Oxides / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D003287:Contrast Media; D010087:Oxides; C030581:gadolinium oxide; D006108:Graphite; D004317:Doxorubicin; D005682:Gadolinium