title: [The first experience of application of standardized genotype technique of identification of HIV-tropism].
abstract: The antagonists of co-receptor CCR5 are an ultimately new class of preparations to treat HIV-infection. The mechanism of action of the preparations of this class is in the selective binding with co-receptor CCR5. This process results in the prevention of penetration of HIV into cell. Before prescribing the CCR5 antagonists the detection of viral tropism has to be done. Recently, in Russia the genotype technique of tropism detection was registered which can be used in clinical practice. The present article describes first experience of application of the given technique to clinical samples. The high correlation was established while comparing with the results of reference laboratory.
authors: A É
authors: AÉ
authors: Lopatukhin
authors: D E
authors: DE
authors: Kireev
authors: A N
authors: AN
authors: Poliakov
authors: E K
authors: EK
authors: Bukin
authors: R
authors: R
authors: Kaiser
authors: N
authors: N
authors: Luebke
authors: D A
authors: DA
authors: Kuevda
authors: G A
authors: GA
authors: Shipulin
mesh_terms: D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D056189:Viral Tropism / Q000235:genetics*
chemical_list: C584933:CCR5 protein, human; D012367:RNA, Viral; D019713:Receptors, CCR5