title: Influence of fluoride treatment on surface properties, biodegradation and cytocompatibility of Mg-Nd-Zn-Zr alloy.
abstract: Fluoride treatment is a commonly used technique or pre-treatment to optimize the degradation kinetic and improve the biocompatibility of magnesium-based implant. The influence of changed surface properties and degradation kinetics on subsequent protein adsorption and cytocompatibility is critical to understand the biocompatibility of the implant. In this study, a patent magnesium alloy Mg-Nd-Zn-Zr alloy (JDBM) designed for cardiovascular stent application was treated by immersion in hydrofluoric acid. A 1.5 μm thick MgF2 layer was prepared. The surface roughness was increased slightly while the surface zeta potential was changed to a much more negative value after the treatment. Static contact angle test was performed, showing an increase in hydrophilicity and surface energy after the treatment. The MgF2 layer slowed down in vitro degradation rate, but lost the protection effect after 10 days. The treatment enhanced human albumin adsorption while no difference of human fibrinogen adsorption amount was observed. Direct cell adhesion test showed many more live HUVECs retained than bare magnesium alloy. Both treated and untreated JDBM showed no adverse effect on HUVEC viability and spreading morphology. The relationship between changed surface characteristics, degradation rate and protein adsorption, cytocompatibility was also discussed.
authors: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors: Jian
authors: J
authors: Zhang
authors: Ni
authors: N
authors: Kong
authors: Jialin
authors: J
authors: Niu
authors: Yongjuan
authors: Y
authors: Shi
authors: Haiyan
authors: H
authors: Li
authors: Yue
authors: Y
authors: Zhou
authors: Guangyin
authors: G
authors: Yuan
mesh_terms: D000497:Alloys / Q000138:chemical synthesis / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology*; D001826:Body Fluids / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D005459:Fluorides / Q000737:chemistry*; D006801:Humans; D017616:Magnesium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008422:Materials Testing; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D017616:Magnesium Compounds; D005459:Fluorides