title: A novel (99m)Tc labelling strategy for the development of silica based particles for medical applications.
abstract: The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.
authors: Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. braband@aci.uzh.ch.
authors: Michel A
authors: MA
authors: Wuillemin
authors: Wanda T
authors: WT
authors: Stuber
authors: Thomas
authors: T
authors: Fox
authors: Michael J
authors: MJ
authors: Reber
authors: Dominik
authors: D
authors: Brühwiler
authors: Roger
authors: R
authors: Alberto
authors: Henrik
authors: H
authors: Braband
mesh_terms: D000475:Alkenes / Q000737:chemistry; D061565:Cycloaddition Reaction; D006801:Humans; D008958:Models, Molecular; D009636:Norbornanes / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D013667:Technetium / Q000737:chemistry
chemical_list: D000475:Alkenes; C509968:MCM-41; D009636:Norbornanes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C046060:2-norbornene; D013667:Technetium; D012822:Silicon Dioxide