title: Hypolipidemic effect of the polysaccharides extracted from pumpkin by cellulase-assisted method on mice.
abstract: The fruit of pumpkin (Cucurbita moschata) is one of the most important vegetables in the world. This study was conducted to investigate the hypolipidemic effect of the polysaccharide isolated from pumpkin (PP). Male Sprague-Dawley rats were divided into three groups and treated with diets containing either high fat, PP, or normal fat. Oral administration of PP could significantly decrease the levels of plasma triacylglycerol (TG), total cholesterol (TC), and plasma low-density lipoprotein cholesterol and increase the levels of fecal fat, cholesterol, and plasma high-density lipoprotein cholesterol. Therefore, results suggest that PP had a high hypolipidemic activity and could be explored as a possible agent for hyperlipidemia.
authors: Microbiology Laboratory, The First People's Hospital of Lian Yun Gang, 182 North Tongguan Road, Xinpu 222002, China.
authors: Xin-Hua
authors: XH
authors: Zhao
authors: Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: qianlilyg@163.com.
authors: Li
authors: L
authors: Qian
authors: Microbiology Laboratory, The First People's Hospital of Lian Yun Gang, 182 North Tongguan Road, Xinpu 222002, China. Electronic address: ydllyg@sina.com.
authors: De-Lu
authors: DL
authors: Yin
authors: Microbiology Laboratory, The First People's Hospital of Lian Yun Gang, 182 North Tongguan Road, Xinpu 222002, China.
authors: Yi
authors: Y
authors: Zhou
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D028464:Cucurbita / Q000737:chemistry*; D005223:Fats / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D005223:Fats; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D011134:Polysaccharides; D002784:Cholesterol
keywords: Hypolipidemic; Polysaccharides; Pumpkin