title: Anti-citrullinated peptide antibodies is more than an accurate tool for diagnosis of rheumatoid arthritis.
abstract: Anti-citrullinated peptide antibodies (ACPA) are detected in the sera of rheumatoid arthritis (RA) patients and have a profound role in diagnosis of the disease. In this review we discuss the different cohorts of RA patients in whom the presence, sensitivity and specificity of ACPA were evaluated. The significance of ACPA in the pathogenesis and prognosis RA is also interpreted. Recent advances in the understanding of molecular pathways involved in the pathogenesis of RA have led to the identification of novel biologic agents that are now widely used in patients with RA.
authors: Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
authors: Kevin
authors: K
authors: Goldman
authors: Rheumatology Research Laboratory, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
authors: Smadar
authors: S
authors: Gertel
authors: Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
authors: Howard
authors: H
authors: Amital
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000503:physiopathology; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D010456:Peptides, Cyclic / Q000276:immunology*; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide