title: Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35-319.65 K.
abstract: Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone,n-butanol andn-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and theλhequation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van't Hoff equation.
authors: College of Biotechnology and Pharmaceutieal Engineering, Nanjing University of Technology, No. 200, North Zhongshan Road, Nanjing, 210009 China.
authors: Yihua
authors: Y
authors: Li
authors: Wenge
authors: W
authors: Yang
authors: Tuan
authors: T
authors: Zhang
authors: Chaoyuan
authors: C
authors: Wang
authors: Kai
authors: K
authors: Wang
authors: Yonghong
authors: Y
authors: Hu
keywords: Gravimetric method; Omeprazole sulfide; Purification; Solubility; Solution thermodynamics