title: Association of neutrophil-lymphocyte ratio with the presence and severity of rheumatic mitral valve stenosis.
abstract: The aim of the study is to investigate the association between the severity of rheumatic mitral valvular disease (RMVD) and the neutrophil-lymphocyte ratio (NLR). A total of 227 patients were enrolled in the study and divided into 3 groups. Patients in group 1 had rheumatic mitral stenosis (RMS), those in group 2 had RMVD without stenosis, and those in group 3 served as the control group. Group 1 was further divided into 2 groups, severe mitral stenosis (MS) and mild to moderate MS. The NLR was significantly higher in patients with severe MS when compared to those with mild to moderate MS (P = .002) while lymphocyte count was lower (P = .034). Using a cutoff level of 2.56, the NLR predicted severe RMS with a sensitivity of 75% and specificity of 74%. In conclusion, as an inexpensive, simple, and accessible marker of inflammation, the NLR may be useful in predicting the presence and severity of MS in patients with RMVD.
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey mrpolatn@gmail.com.
authors: Nihat
authors: N
authors: Polat
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Abdulkadir
authors: A
authors: Yildiz
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Murat
authors: M
authors: Yuksel
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Mehmet Zihni
authors: MZ
authors: Bilik
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Mesut
authors: M
authors: Aydin
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Halit
authors: H
authors: Acet
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Mehmet Ata
authors: MA
authors: Akil
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Mustafa
authors: M
authors: Oylumlu
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Hasan
authors: H
authors: Kaya
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Faruk
authors: F
authors: Ertas
authors: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Habib
authors: H
authors: Cil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000276:immunology*; D009504:Neutrophils; D012214:Rheumatic Heart Disease / Q000276:immunology*; D012720:Severity of Illness Index
keywords: inflammation; mitral stenosis; neutrophil to lymphocyte ratio; rheumatic valve disease