title: Biliary complications after orthotopic liver transplantation: the Hungarian experience.
abstract: Biliary complications (BC) significantly affect morbidity and mortality after orthotopic liver transplantation (OLT). The aim of this study was to analyze the incidence and types of biliary complications after OLT in Hungary. We retrospectively analyzed data of 471 adult liver transplant recipients between 1995 and 2011. Biliary complications occurred in 28% of patients. The most frequent BCs were bile duct stricture, stenosis (19%), biliary leakage (12%), and necrosis (BN: 6.4%). Biliary complications were associated with the incidence of acute rejection (51% vs 31%; P = .003), hepatic artery thrombosis (43% vs 11%; P < .001), and hepatic artery stenosis (26% vs 11%; P = .002). When cold ischemic time was longer than 12 hours, leakage (10% vs 3%; P = .043), ischemic type biliary lesion (20% vs 3.4%; P = .05), and BN (12% vs 3%; P = .067) were more often diagnosed post-OLT. Most of the biliary complications were treated by radiologic interventions (70%). Bile duct necrosis was associated with lower graft and patient survival. In conclusion, acute rejection, hepatic artery thrombosis/stenosis and cold ischemic time longer than 12 hours increase the incidence of BCs. Successful management of these risk factors can reduce the incidence of biliary complications and improve mortality.
authors: Departure of Transplantation and Surgery Budapest, Hungary. Electronic address: gyorgy.gaman@gmail.com.
authors: G
authors: G
authors: Gámán
authors: F
authors: F
authors: Gelley
authors: A
authors: A
authors: Doros
authors: G
authors: G
authors: Zádori
authors: D
authors: D
authors: Görög
authors: I
authors: I
authors: Fehérvári
authors: L
authors: L
authors: Kóbori
authors: B
authors: B
authors: Nemes
mesh_terms: D000208:Acute Disease; D057868:Anastomotic Leak / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D001157:Arterial Occlusive Diseases / Q000453:epidemiology; D002779:Cholestasis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D050377:Cold Ischemia / Q000009:adverse effects; D003141:Communicable Diseases / Q000453:epidemiology; D003251:Constriction, Pathologic; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006499:Hepatic Artery; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D009336:Necrosis; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome