title: Omentin serum levels and omentin gene Val109Asp polymorphism in patients with psoriasis.
abstract: BACKGROUND
  Psoriasis is a chronic inflammatory disease of uncertain pathogenesis. Omentin is a new adipokine with anti-inflammatory properties; however, the relationship between psoriasis and omentin has not been fully established yet.
  
  
  OBJECTIVE
  This study was designed to evaluate the relationship between psoriasis and omentin serum levels and Val109Asp polymorphism in exon 4 of the omentin gene.
  
  
  METHODS
  Forty-nine patients with plaque-type psoriasis and 39 healthy subjects were included in the study. Omentin concentrations were determined by using enzyme-linked immunosorbent assay. Val109Asp polymorphism in exon 4 of the omentin gene was assessed by the polymerase chain reaction-restriction fragment length polymorphism method. Genotypes were determined according to the bands formed in agarose electrophoresis gels. In the statistical analysis, the level of significance was set at P < 0.05.
  
  
  RESULTS
  The serum omentin levels of the patients with psoriasis (354.2 ± 152.0) were found to be significantly lower than those in the control group (488.7 ± 190.3) (P = 0.001). A moderate level negative correlation was determined between serum omentin level and body mass index and waist circumference. No significant differences were observed between the patient and control groups in terms of the genotype and allele frequency of Val109Asp polymorphism in exon 4 of the omentin gene (P > 0.05).
  
  
  CONCLUSIONS
  Omentin serum levels were determined to be low in patients with psoriasis. No significant difference was found regarding Val109Asp polymorphism of the omentin gene. To the best of our knowledge, our study is the first clinical study to examine the relationship between psoriasis and omentin in terms of serum and genomic levels.
authors: Department of Dermatology, Duzce University Medical Faculty, Duzce, Turkey.
authors: Hakan
authors: H
authors: Turan
authors: Kursat Oguz
authors: KO
authors: Yaykasli
authors: Hatice
authors: H
authors: Soguktas
authors: Emine
authors: E
authors: Yaykasli
authors: Cihangir
authors: C
authors: Aliagaoglu
authors: Teoman
authors: T
authors: Erdem
authors: Mutlu
authors: M
authors: Karkucak
authors: Ertugrul
authors: E
authors: Kaya
authors: Taner
authors: T
authors: Ucgun
authors: Anzel
authors: A
authors: Bahadir
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000097:blood* / Q000235:genetics*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins