title: Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease.
abstract: The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
authors: Cristina
authors: C
authors: Gussago
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
authors: Beatrice
authors: B
authors: Arosio
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Martina
authors: M
authors: Casati
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Evelyn
authors: E
authors: Ferri
authors: Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
authors: Federica
authors: F
authors: Gualandris
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
authors: Enzo
authors: E
authors: Tedone
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Paola
authors: P
authors: Nicolini
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Paolo Dionigi
authors: PD
authors: Rossi
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Carlo
authors: C
authors: Abbate
authors: Geriatric Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Department of Medical Sciences and Community Health, University of Milan, Geriatrics, Milan, Italy.
authors: Daniela
authors: D
authors: Mari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology; D015140:Dementia, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D043705:Receptor, Adenosine A2A / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D043705:Receptor, Adenosine A2A
keywords: Adenosine receptors; Alzheimer's disease; biomarker; vascular dementia