title: Application of Dempster-Schafer method in family-based association studies.
abstract: In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has a promising overall performance, in identifying single-nucleotide polymorphisms in the correct association class, as it has 90 percent accuracy even with 60 trios.
authors: Turgut Özal University, Ankara.
authors: Farid
authors: F
authors: Rajabli
authors: Turgut Özal University, Ankara.
authors: Unal
authors: U
authors: Göktaş
authors: Middle East Technical University, Ankara.
authors: Gül
authors: G
authors: Inan
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D020641:Polymorphism, Single Nucleotide