title: Comparison of the safety of seven iodinated contrast media.
abstract: We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared between different IOCM at the system organ level using the proportional reporting ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified as frequently reported media. 'Platelet, bleeding & clotting disorders' (PRR, 29.6; 95%CI, 1.9-472.6) and 'urinary system disorders' (PRR, 22.3; 95% CI, 17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In conclusion, the frequency of AEs by organ class was significantly different between individual media. These differences among different IOCM should be considered when selecting a medium among various IOCM and when monitoring patients during and after its use to ensure optimum usage and patient safety.
authors: Office of Drug Safety Information II, Korea Institute of Drug Safety & Risk Management, Seoul, Korea. ; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Jong-Mi
authors: JM
authors: Seong
authors: Nam-Kyong
authors: NK
authors: Choi
authors: Joongyub
authors: J
authors: Lee
authors: Yoosoo
authors: Y
authors: Chang
authors: Ye-Jee
authors: YJ
authors: Kim
authors: Bo Ram
authors: BR
authors: Yang
authors: Xue-Mei
authors: XM
authors: Jin
authors: Ju-Young
authors: JY
authors: Kim
authors: Byung-Joo
authors: BJ
authors: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001791:Blood Platelet Disorders / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000009:adverse effects*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D014570:Urologic Diseases / Q000139:chemically induced; D055815:Young Adult
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals
keywords: Adverse Drug Reaction Reporting Systems; Contrast Media; Patient Safety