title: No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis.
abstract: OBJECTIVE
  STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes.
  
  
  METHODS
  Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain.
  
  
  RESULTS
  No statistically significant differences were found when allele and genotype distributions were compared between non-anterior uveitis patients and controls for any STAT4 (rs3821236: P=0.39, OR=1.12, CI 95%=0.87-1.43; rs7574865: P=0.59 OR=1.07, CI 95%=0.84-1.37; rs7574070: P=0.26, OR=0.89, CI 95%=0.72-1.10; rs897200: P=0.22, OR=0.88, CI 95%=0.71-1.08;) or IL23R polymorphisms (rs7517847: P=0.49, OR=1.08, CI 95%=0.87-1.33; rs11209026: P=0.26, OR=0.78, CI 95%=0.51-1.21; rs1495965: P=0.51, OR=0.93, CI 95%=0.76-1.15).
  
  
  CONCLUSIONS
  Our results do not support a relevant role, similar to that described for other autoimmune diseases, of IL23R and STAT4 polymorphisms in the non-anterior uveitis genetic predisposition. Further studies are needed to discard a possible weak effect of the studied variant.
authors: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN, CSIC, Granada, Spain.
authors: María Carmen
authors: MC
authors: Cénit
authors: Ana
authors: A
authors: Márquez
authors: Miguel
authors: M
authors: Cordero-Coma
authors: Marina Begoña
authors: MB
authors: Gorroño-Echebarría
authors: Alejandro
authors: A
authors: Fonollosa
authors: Alfredo
authors: A
authors: Adán
authors: Agustín
authors: A
authors: Martínez-Berriotxoa
authors: David
authors: D
authors: Díaz Valle
authors: Esperanza
authors: E
authors: Pato
authors: Ricardo
authors: R
authors: Blanco
authors: Joaquín
authors: J
authors: Cañal
authors: Manuel
authors: M
authors: Díaz-Llopis
authors: José Luis
authors: JL
authors: García Serrano
authors: Enrique
authors: E
authors: de Ramón
authors: María José
authors: MJ
authors: Del Rio
authors: José Manuel
authors: JM
authors: Martín-Villa
authors: Blanca
authors: B
authors: Molins
authors: Norberto
authors: N
authors: Ortego-Centeno
authors: Javier
authors: J
authors: Martín
mesh_terms: D000328:Adult; D000483:Alleles; D015551:Autoimmunity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D050797:STAT4 Transcription Factor / Q000235:genetics*; D014605:Uveitis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin; D050797:STAT4 Transcription Factor