title: New furoquinoline alkaloids from the leaves of Evodia lepta.
abstract: Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 μM. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 μM.
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors: Jirapast
authors: J
authors: Sichaem
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors: Apapond
authors: A
authors: Jirasirichote
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors: Krittakorn
authors: K
authors: Sapasuntikul
authors: Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand.
authors: Suttira
authors: S
authors: Khumkratok
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors: Pattara
authors: P
authors: Sawasdee
authors: Department of Organic Chemistry, University of Science, National University-Ho Chi Minh City, 748355 Ho Chi Minh City, Viet Nam.
authors: Thi My Lien
authors: TM
authors: Do
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Santi.Ti@chula.ac.th.
authors: Santi
authors: S
authors: Tip-pyang
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032086:Evodia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: AChE and BChE activities; Evodia lepta; Furoquinoline alkaloids; Rutaceae