title: Sono-assembly of highly biocompatible polysaccharide capsules for hydrophobic drug delivery.
abstract: Cells like sugar. General synthesis and potential of intracellular hydrophobic drug delivery of single-component polysaccharide capsules are pursued. The capsules can be generally assembled through hydrogen bonding networks but show striking shell robustness. The evidenced cell internalization, stimuli-responsiveness to local pH changes and high biocompatibilities of the capsules specifically favor their potential intracellular drug delivery.
authors: Max Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany.
authors: Hongqiang
authors: H
authors: Wang
authors: Xuehai
authors: X
authors: Yan
authors: Guo Liang
authors: GL
authors: Li
authors: Christine
authors: C
authors: Pilz-Allen
authors: Helmuth
authors: H
authors: Möhwald
authors: Dmitry
authors: D
authors: Shchukin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D002214:Capsules / Q000737:chemistry / Q000378:metabolism*; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry*; D013010:Sonication; D013696:Temperature; D014050:Toluene / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D014050:Toluene; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate
keywords: biocompatibility; capsules; hydrophobic drug delivery; polysaccharide; sonochemistry