title: IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis.
abstract: BACKGROUND
  IgG4-related systemic disease (IgG4-RSD) is a recently recognised fibroinflammatory condition, characterized by a tissue infiltration and/or enlargement and typical histopathological findings.
  
  
  RESULTS
  We report on a 73-year-old male with bilateral preauricular swelling and a remote history of unexplained systemic disease. Magnetic resonance imaging showed enlargement of all major salivary glands and cervical lymph node due to a tissue infiltration with marked enhancement and restricted diffusion. Elevated serum IgG4 levels and histopathological findings on an excisional lymph node biopsy were consistent with IgG4-RSD.
  
  
  CONCLUSIONS
  Magnetic resonance imaging seems to be a useful tool to support the diagnosis of IgG4-related systemic disease of salivary glands.
authors: Department of Radiology, University Hospitals Leuven, Belgium.
authors: Laurens J
authors: LJ
authors: De Cocker
authors: Department of Diagnostic Imaging and Radiotherapy, University Federico II Naples, Italy. Electronic address: darcofel@gmail.com.
authors: Felice
authors: F
authors: D'Arco
authors: Department of Radiology, University Hospitals Leuven, Belgium.
authors: Tom
authors: T
authors: De Beule
authors: Department of Pathology, University Hospitals Leuven, Belgium.
authors: Thomas
authors: T
authors: Tousseyn
authors: Department of General Internal Medicine, University Hospitals Leuven, Belgium.
authors: Daniel
authors: D
authors: Blockmans
authors: Department of Radiology, University Hospitals Leuven, Belgium.
authors: Robert
authors: R
authors: Hermans
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D001706:Biopsy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007249:Inflammation; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000276:immunology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010306:Parotid Gland / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology; D012793:Sialadenitis / Q000276:immunology / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G
keywords: Chronic sclerosing sialadenitis; IgG4-related systemic disease; Küttner tumor; Lymphadenitis; MRI; Parotid gland