title: Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder.
abstract: Schizophrenia patients experience cognitive control disturbances, manifest in altered neural signatures during action monitoring. It remains unclear whether error- and conflict-monitoring disturbances co-occur, and whether they are observed in recent-onset psychosis patients with schizophrenia or bipolar disorder. We tested electrophysiological measures of action monitoring in these patients. Seventy-three schizophrenia patients (SZ), 26 bipolar disorder type I patients (BP), each within one year of psychosis onset, and 54 healthy control subjects (HC) underwent EEG during Stroop task performance. In the trial-averaged EEG at three midline scalp electrodes, the error-related negativity (ERN), error positivity (Pe) and conflict-related N450 were measured. Compared to HC (1) SZ exhibited an attenuated ERN and N450, and Pe unchanged and (2) BP exhibited an attenuated ERN but normal Pe and N450. Between patient groups, SZ showed an attenuated N450; ERN and Pe were not significantly different. A small (n=10) SZ subgroup that was not receiving antipsychotic medication showed normal ERPs. Altered error- and conflict-monitoring occur together in the first-episode schizophrenia patients, and these measures are comparable in patients with the first-episode bipolar disorder. Antipsychotic medication may be associated with altered measures of error-monitoring in schizophrenia.
authors: Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA, United States. Electronic address: Michael.minzenberg@ucsf.edu.
authors: Michael J
authors: MJ
authors: Minzenberg
authors: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, United States.
authors: Glenn C
authors: GC
authors: Gomes
authors: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, United States.
authors: Jong H
authors: JH
authors: Yoon
authors: Department of Psychology, University of California, Davis, CA, United States.
authors: Tamara Y
authors: TY
authors: Swaab
authors: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, United States.
authors: Cameron S
authors: CS
authors: Carter
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000150:complications* / Q000523:psychology; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011597:Psychomotor Performance / Q000502:physiology*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology
keywords: Conflict; Error positivity; Error-related negativity; N450; Performance adjustment; Stroop