title: Thin layer chromatographic analysis of Beta-lactam antibiotics.
abstract: OBJECTIVE
  The paper describes some thin layer chromatographic procedures that allow simple and rapid separation and identification of penicillins and cephalosporins from complex mixtures.
  
  
  METHODS
  Using silicagel GF254 as stationary phase and selecting different mobile phases we succeeded in the separation of the studied beta-lactamins. Our aim was not only to develop a simple, rapid and efficient method for their separation but also the optimization of the analytical conditions.
  
  
  RESULTS
  No system will separate all the beta-lactams, but they could be identified when supplementary information is used from color reactions and/or by using additional chromatographic systems.
  
  
  CONCLUSIONS
  The right combination of solvent system and detection method allows the identification of the studied penicillins and cephalosporins and can be successfully used in the preliminary analysis beta-lactam antibiotics.
  
  
  CONCLUSIONS
  The right combination of solvent system and detection method allows the identification of the studied penicillins and cephalosporins and can be successfully used in the preliminary analysis beta-lactam antibiotics.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, Târgu Mureş, Romania.
authors: Gabriel
authors: G
authors: Hancu
authors: Brigitta
authors: B
authors: Simon
authors: Hajnal
authors: H
authors: Kelemen
authors: Aura
authors: A
authors: Rusu
authors: Eleonora
authors: E
authors: Mircia
authors: Arpad
authors: A
authors: Gyeresi
keywords: Beta-lactam antibiotics; Cephalosporins; Penicillins; Separation; Thin layer chromatography