title: Complex dynamic substrate control: dual-tone hydrogel photoresists allow double-dissociation of topography and modulus.
abstract: Complex substrate control is demonstrated with a dual-tone hydrogel photoresist. By exposing a photodegradable hydrogel to UV light through a photomask, both swollen and eroded micropatterns with a decreased modulus can be created on the surface under different exposure conditions. This provides an important tool for investigating the synergistic effects of spatially heterogeneous mechanical and topological cues on cell behavior.
authors: Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, 4121 Eng V, Los Angeles, CA, 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA, 90095, USA.
authors: Changying
authors: C
authors: Xue
authors: Darice Y
authors: DY
authors: Wong
authors: Andrea M
authors: AM
authors: Kasko
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D010782:Photolysis; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols
keywords: complex topographic patterns; dual-tone photoresist; dynamic control; elastic pattern; photodegradable hydrogels