title: BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
abstract: At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of V(H)-DJ(H) gene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia suppression.
authors: Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
authors: Srividya
authors: S
authors: Swaminathan
authors: Departments of Medicine and Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
authors: Cihangir
authors: C
authors: Duy
authors: Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: markus.muschen@ucsf.edu.
authors: Markus
authors: M
authors: Müschen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000378:metabolism; D054420:Pre-B Cell Receptors / Q000276:immunology / Q000378:metabolism*; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6
chemical_list: C491123:BACH2 protein, human; C084103:BCL6 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D054420:Pre-B Cell Receptors; D051560:Proto-Oncogene Proteins c-bcl-6
keywords: BACH2; BCL6; leukemogenesis; negative selection; pre-B cell receptor checkpoint