title: Cell therapy of refractory Crohn's disease.
abstract: We analyzed medium-term efficiency and safety of biological therapy of Crohn's disease, in particular transplantation of allogenic mesenchymal stromal bone marrow cells and anticytokine therapy with selective immunosuppressive agents. It was found that both methods of biological therapy of refractory Crohn's disease resulted in clinical and in some cases endoscopic remission. In most cases, clinical remission was maintained without steroid hormone therapy. Thus, both methods produce comparable clinical results. It was concluded that transplantation of mesenchymal stromal bone marrow cells could be considered as a promising method in the therapy of refractory Crohn's disease comparable by its efficiency with infliximab therapy.
authors: Central Research Institute of Gastroenterology, Moscow Department of Health Care; Medical Radiological Research Center, Ministry of Health Care of the Russian Federation, Obninsk, Russia. oleg7@bk.ru.
authors: O V
authors: OV
authors: Knyazev
authors: A I
authors: AI
authors: Parfenov
authors: P L
authors: PL
authors: Shcherbakov
authors: I N
authors: IN
authors: Ruchkina
authors: A G
authors: AG
authors: Konoplyannikov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002478:Cells, Cultured; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D000069285:Infliximab; D001379:Azathioprine