title: Effect of genetic polymorphisms of vascular endothelial growth factor on left ventricular hypertrophy in patients with systemic hypertension.
abstract: Vascular endothelial growth factor (VEGF) is a cytokine involved in angiogenesis and upregulated during adaptive heart hypertrophy. Downregulation of VEGF seems to trigger the transition from adaptive to dilated cardiac hypertrophy. We investigated for the first time whether 3 clinically relevant polymorphisms in the VEGFA gene are associated with altered echocardiographic parameters in hypertensive patients. We determined genotypes for 3 polymorphisms in VEGFA promoter in 179 hypertensive patients and 169 healthy controls: g.-2578C>A (rs699947), g.-1154G>A (rs1570360), and g.-634G>C (rs2010963). Although the variant genotypes of the g.-634G>C (GC + CC) were associated with reduced left ventricular mass index (p = 0.030), the variant genotypes for the g.-1154G>A (GA + AA) were associated with reduced ejection fraction (p = 0.008). In addition, we found that VEGFA haplotypes were associated with altered ejection fraction (p = 0.024). The AAG haplotype was associated with reduced ejection fraction (p = 0.006), whereas the AGG haplotype was associated with increased ejection fraction (p = 0.010). Our results suggest that VEGF polymorphisms affect cardiac remodeling. Genotypes for VEGFA polymorphisms can be useful to help to identify hypertensive patients at greater intrinsic risk for heart failure.
authors: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors: Riccardo
authors: R
authors: Lacchini
authors: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors: Marcelo Rizzatti
authors: MR
authors: Luizon
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors: Sandra
authors: S
authors: Gasparini
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors: Maria C
authors: MC
authors: Ferreira-Sae
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors: Roberto
authors: R
authors: Schreiber
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors: Wilson
authors: W
authors: Nadruz
authors: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address: tanussantos@yahoo.com.
authors: Jose E
authors: JE
authors: Tanus-Santos
mesh_terms: D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D004247:DNA