title: Dopamine transporter dysfunction in Han Chinese people with chronic methamphetamine dependence after a short-term abstinence.
abstract: Single-photon emission-computed tomography (SPECT) after the administration of (99m)Tc-TRODAT-1 was performed on healthy subjects and subjects with methamphetamine (METH)dependence at time 1 (T1) after 24-48 h of abstinence, time 2 (T2) after 2 weeks of abstinence, and time 3 (T3) after 4 weeks of abstinence. In contrast to values in controls, the values of the striatal DAT specific uptake ratios (SURs) in subjects with METH dependence were significantly lower at T1 (n=25), T2 (n=9), and T3 (n=8); a mild increase in SURs was observed at T2 and T3, but values were still significantly lower than those in controls. In subjects with METH dependence, there was a trend for a negative correlation of striatal DAT SURs and craving for METH at T1. METH craving, anxiety and depression scores significantly decreased from T1 to T2 to T3. We conclude that Han Chinese people with METH dependence experience significant striatal DAT dysfunction, and that these changes may be mildly reversible after 4 weeks of abstinence, but that DAT levels still remain significantly lower than those in healthy subjects. The mild recovery of striatal DAT may parallel improvements in craving, anxiety and depression.
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
authors: Jie
authors: J
authors: Yuan
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
authors: Rongbin
authors: R
authors: Lv
authors: Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: James
authors: J
authors: Robert Brašić
authors: College of Chemistry, Beijing Normal University, Beijing, China.
authors: Mei
authors: M
authors: Han
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: xingdliu@yahoo.com.
authors: Xingdang
authors: X
authors: Liu
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
authors: Yuankai
authors: Y
authors: Wang
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
authors: Guangming
authors: G
authors: Zhang
authors: Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
authors: Congjin
authors: C
authors: Liu
authors: Drug Rehabilitation Centre, Shanghai, China.
authors: Yu
authors: Y
authors: Li
authors: Department of Clinical Pharmacology National Institute on Drug Dependence, Peking University, Beijing, China.
authors: Yanping
authors: Y
authors: Deng
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging / Q000208:ethnology* / Q000523:psychology; D001007:Anxiety / Q000000981:diagnostic imaging / Q000208:ethnology / Q000523:psychology; D044466:Asian People / Q000523:psychology / Q000706:statistics & numerical data; D001931:Brain Mapping; D016022:Case-Control Studies; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D003863:Depression / Q000000981:diagnostic imaging / Q000208:ethnology / Q000523:psychology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage* / Q000009:adverse effects; D015609:Organotechnetium Compounds / Q000378:metabolism; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D015609:Organotechnetium Compounds; D008694:Methamphetamine
keywords: (99m)Tc-TRODAT-1; Dopamine transporter (DAT) tomography; Emission-computed; Methamphetamine (METH) abuse; Single-photon