title: Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study.
abstract: BACKGROUND
  Selenium (Se) is a necessary element for the biosynthesis of thyroid hormones. We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area.
  
  
  METHODS
  We selected residents of Chengdu (over 18 years old and living in the city for more than 5 years) using a stratified cluster sampling technique. Fifteen hundred subjects were selected for the study, which involved a questionnaire survey, physical examination, thyroid ultrasound, serum thyroid function test, and determination of serum selenium level. Thyroid volume was calculated from the thickness, width, length, and a corrective factor for each lobe. Ultimately, 1,205 subjects completed the investigation and were included in our study. Additionally, 80 school-age children were selected to provide urine samples for urinary iodine analysis. We analyzed the data using appropriate nonparametric and parametric statistical tests.
  
  
  RESULTS
  The median urinary iodine value was 184 μg/L in school-age children, indicating iodine sufficiency. The median serum selenium level of the 1,205 subjects was 52.63 (interquartile range [IQR] : 40.40-67.00) μg/L. The median thyroid volume was 9.93 (IQR: 7.71-12.57) mL; both log-transformed serum selenium and log-transformed thyroid volume were Gaussian distributions (P = .638 and P = .046, respectively). The prevalences of goiter and thyroid nodules were 8.8% and 18.6%. The prevalences of positive thyroid autoantibodies, thyroperoxidase autoantibodies and thyroglobulin autoantibodies were 16.7%, 12.0%, and 11.1%, respectively. In the general linear regression model, there were positive associations between serum selenium and age, and body mass index. We found no association between serum selenium and thyroid-stimulating hormone. In simple linear regression analyses, we found no association between thyroid volume and serum selenium. There were no significant differences in serum selenium between persons with or without goiter. Serum selenium was not a risk factor for goiter.
  
  
  CONCLUSIONS
  In our study population, serum selenium was neither associated with thyroid volume nor with goiter in an iodine-sufficient area. More studies should be conducted by following non-goitrous persons over time and monitoring their selenium status.
authors: Yang
authors: Y
authors: Liu
authors: Department of Endocrinology, West China Hospital, Sichuan University, No,37 Guoxue Lane, Chengdu, Sichuan Province 610041, China. huanghui11@yahoo.com.cn.
authors: Hui
authors: H
authors: Huang
authors: Jing
authors: J
authors: Zeng
authors: Chengjun
authors: C
authors: Sun
mesh_terms: D001323:Autoantibodies / Q000097:blood; D002648:Child; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006042:Goiter / Q000453:epidemiology*; D006801:Humans; D007455:Iodine / Q000652:urine*; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015995:Prevalence; D012643:Selenium / Q000097:blood*; D018709:Statistics, Nonparametric; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000276:immunology; D016606:Thyroid Nodule / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D007455:Iodine; D012643:Selenium