title: Cancer stem cells: A contentious hypothesis now moving forward.
abstract: Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
authors: Michael L
authors: ML
authors: O'Connor
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
authors: Dongxi
authors: D
authors: Xiang
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
authors: Sarah
authors: S
authors: Shigdar
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
authors: Joanna
authors: J
authors: Macdonald
authors: Cancer Care Centre, St. George Hospital, and St. George Clinical School, Faculty of Medicine, University of New South Wales, Kensington, NSW 2052, Australia.
authors: Yong
authors: Y
authors: Li
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
authors: Tao
authors: T
authors: Wang
authors: Dalian Sixth People's Hospital, Dalian 116033, China.
authors: Chunwen
authors: C
authors: Pu
authors: Dalian Sixth People's Hospital, Dalian 116033, China.
authors: Zhidong
authors: Z
authors: Wang
authors: Storr Liver Unit, Westmead Millennium Institute, The University of Sydney at the Westmead Hospital, Westmead, NSW 2145, Australia. Electronic address: liang.qiao@sydney.edu.au.
authors: Liang
authors: L
authors: Qiao
authors: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia. Electronic address: wduan@deakin.edu.au.
authors: Wei
authors: W
authors: Duan
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*
keywords: Aptamers; Cancer stem cells; Chemoresistance; Clonal evolution; Stemness