title: Feeling at home from arrival to departure: protein export and host cell remodelling during Plasmodium liver stage and gametocyte maturation.
abstract: Obligate intracellular pathogens actively remodel their host cells to boost propagation, survival, and persistence. Plasmodium falciparum, the causative agent of the most severe form of malaria, assembles a complex secretory system in erythrocytes. Export of parasite factors to the erythrocyte membrane is essential for parasite sequestration from the blood circulation and a major factor for clinical complications in falciparum malaria. Historic and recent molecular reports show that host cell remodelling is not exclusive to P. falciparum and that parasite-induced intra-erythrocytic membrane structures and protein export occur in several Plasmodia. Comparative analyses of P. falciparum asexual and sexual blood stages and imaging of liver stages from transgenic murine Plasmodium species show that protein export occurs in all intracellular phases from liver infection to sexual differentiation, indicating that mammalian Plasmodium species evolved efficient strategies to renovate erythrocytes and hepatocytes according to the specific needs of each life cycle phase. While the repertoireof identified exported proteins is remarkably expanded in asexual P. falciparum blood stages, the putative export machinery and known targeting signatures are shared across life cycle stages. A better understanding of the molecular mechanisms underlying Plasmodium protein export could assist in designing novel strategies to interrupt transmission between Anopheles mosquitoes and humans.
authors: Max Planck Institute for Infection Biology, Parasitology Unit, 10117, Berlin, Germany.
authors: Alyssa
authors: A
authors: Ingmundson
authors: Pietro
authors: P
authors: Alano
authors: Kai
authors: K
authors: Matuschewski
authors: Francesco
authors: F
authors: Silvestrini
mesh_terms: D021961:Cell Membrane Structures / Q000469:parasitology; D049109:Cell Proliferation; D004910:Erythrocyte Membrane / Q000469:parasitology / Q000473:pathology*; D022781:Hepatocytes / Q000469:parasitology / Q000473:pathology*; D008018:Life Cycle Stages; D008099:Liver / Q000469:parasitology / Q000473:pathology; D016778:Malaria, Falciparum / Q000469:parasitology; D010963:Plasmodium falciparum / Q000254:growth & development / Q000378:metabolism*; D021381:Protein Transport; D015800:Protozoan Proteins / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan