title: Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast.
abstract: Cytotoxic effects of zinc oxide (ZnO) nanomaterials, individual and conjugated with a photosensitizer (protoporphyrin IX), were studied in the presence and absence of ultraviolet light exposure (240 nm of light wavelength for a very short time exposure) in cell cultures of human normal and cancerous skin models. Zinc Oxide nanowires (ZnO NWs) were grown on the capillary tip and conjugated with protoporphyrin IX (PpIX). This coated tip was used as tool/pointer for intracellular drug delivery protocol in suggested normal as well as carcinogenic cellular models. After true delivery of optimal drug, the labelled biological model was irradiated with UV-A, which led to a loss of mitochondrial membrane potential, as tested by neutral red assay (NRA).
authors: Department of Physics, GC University, Faisalabad, Pakistan, fakharphy@gmail.com.
authors: Muhammad
authors: M
authors: Fakhar-e-Alam
authors: S
authors: S
authors: Kishwar
authors: M
authors: M
authors: Willander
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D053770:Nanowires / Q000627:therapeutic use* / Q000648:ultrastructure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011524:Protoporphyrins / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*; D014466:Ultraviolet Rays; D015034:Zinc Oxide / Q000627:therapeutic use*
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; C028025:protoporphyrin IX; D015034:Zinc Oxide