title: New Delhi metallo-β-lactamase-producing Acinetobacter baumannii: a novel paradigm for spreading antibiotic resistance genes.
abstract: The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and Pseudomonas aeruginosa. However, recent findings regarding the spread of the blaNDM carbapenemase genes revealed that A. baumannii likely acts as a source of emerging antibiotic resistance genes. The analysis of genetic structure surrounding the blaNDM-1 gene revealed that the genetic structure (Tn125) responsible for its dissemination most probably originates from Acinetobacter. Moreover, analysis of the blaNDM-1 gene itself demonstrated that it might be constructed in Acinetobacter through a recombination event with another resistance gene found in A. baumannii (aphA6). This novel paradigm highlights a novel and unexpected role played by A. baumannii.
authors: INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France.
authors: Rémy A
authors: RA
authors: Bonnin
authors: Laurent
authors: L
authors: Poirel
authors: Patrice
authors: P
authors: Nordmann
mesh_terms: D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics*; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D019143:Evolution, Molecular; D023061:Gene Order; D022761:Gene Transfer, Horizontal; D011995:Recombination, Genetic; D026801:Synteny; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D001618:beta-Lactamases