title: Relationship between the argyrophilic proteins of the nucleolar organizer region and stage of squamous-cell carcinoma of the lung.
abstract: Argyrophilic proteins associated with chromosome nucleolar organizer regions (Ag-NOR proteins) were studied in lung squamous-cell carcinoma cells. After routine staining with silver nitrate, the area index and coefficient of variations of Ag-NOR protein were estimated by computer-aided image analysis. The Ag-NOR protein area indexes of tumor cells differed in clinical morphological variants of squamous-cell cancer (differing by T and N parameters, size of the primary node <3 cm or larger, by disease stage, and differentiation degree). Ag-NOR protein variation coefficient can be used for discriminating the tumors by size (<3 cm and larger), presence/absence of metastases, and evaluation of squamous-cell cancer differentiation degree. Ag-NOR protein area index and variation coefficient can be used as additional objective differential diagnostic criteria of clinical and morphological forms of squamous-cell carcinoma of the lung.
authors: Altai Affiliated Department of N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences; Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul; Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru.
authors: D S
authors: DS
authors: Kobyakov
authors: V V
authors: VV
authors: Klimachev
authors: A M
authors: AM
authors: Avdalyan
authors: I P
authors: IP
authors: Bobrov
authors: E Yu
authors: EY
authors: Bychkova
authors: A F
authors: AF
authors: Lazarev
authors: E L
authors: EL
authors: Lushnikova
authors: L M
authors: LM
authors: Nepomnyashchikh
mesh_terms: D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000378:metabolism*; D047368:Tumor Burden
chemical_list: D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins