title: Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran.
abstract: OBJECTIVE
  The purpose of this research was to analyze cagA and vacA genotypes status in H. pylori isolates and relationship with clinical outcomes.
  
  
  METHODS
  Gastric biopsy specimens were cultured for H. pylori isolation and cagA and vacA genes were detected in these isolates. Data were collected and the results were analyzed using χ2 and Fishers exact tests by SPSS software version. 16.
  
  
  RESULTS
  Of the total 115 H. pylori isolates, 79 (68.7 %) were cagA positive and 82 (71.3%) of isolates contained the s1 allele which 33 (28.7%) were subtype s2. s1m2 was the most frequent vacA allelic combination in the H. pylori isolates examined (63 cases), followed by s2m2 (31 cases), s1m1 (19 cases) and s2m1 (2 case). Strains cagA positive were more frequent in peptic ulcer diseases patients than non ulcer diseases patients, as 47 (59.5%) and 32 (40.5%), while cagA negative were low, as 15 (41.7%) and 21 (58.3%), respectively.
  
  
  CONCLUSIONS
  We found that the cagA and vacA status were not related to clinical outcomes in this area. Overall, in the present study, vacA s1/m2, cagA-positive strains were predominant irrespective of clinical outcome, but s2/m1 was rare.
authors: Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ; Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Reza
authors: R
authors: Ghotaslou
authors: Morteza
authors: M
authors: Milani
authors: Mohammad Taghi
authors: MT
authors: Akhi
authors: Mohammad Reza
authors: MR
authors: Nahaei
authors: Alka
authors: A
authors: Hasani
authors: Mohammad Saeid
authors: MS
authors: Hejazi
authors: Mohammad
authors: M
authors: Meshkini
keywords: H. pylori; cagA gene; vacA gene