title: The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
abstract: nPOD actively promotes a multidisciplinary and unbiased approach toward a better understanding of T1D and identify novel therapeutic targets, through its focus on the study of human samples. Unique to this effort is the coordination of collaborative efforts and real-time data sharing. Studies supported by nPOD are providing direct evidence that human T1D isa complex and heterogeneous disease, in which a multitude of pathogenic factors may be operational and may contribute to the onset of the disease. Importantly, the concept that beta cell destruction is almost completed and that the autoimmune process is almost extinguished soon after diagnosis is being challenged. nPOD investigators are exploring the hypothesis that beta cell dysfunction may also be a significant cause of hyperglycemia, at least around the time of diagnosis, and are uncovering novel molecules and pathways that are linked to the pathogenesis and etiology of human T1D. The validation of therapeutic targets is also a key component of this effort, with recent and future findings providing new strategic direction for clinical trials.
authors: Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Immunology and Microbiology, University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Alberto
authors: A
authors: Pugliese
authors: Mingder
authors: M
authors: Yang
authors: Irina
authors: I
authors: Kusmarteva
authors: Tiffany
authors: T
authors: Heiple
authors: Francesco
authors: F
authors: Vendrame
authors: Clive
authors: C
authors: Wasserfall
authors: Patrick
authors: P
authors: Rowe
authors: Jayne M
authors: JM
authors: Moraski
authors: Suzanne
authors: S
authors: Ball
authors: Les
authors: L
authors: Jebson
authors: Desmond A
authors: DA
authors: Schatz
authors: Roberto
authors: R
authors: Gianani
authors: George W
authors: GW
authors: Burke
authors: Concepcion
authors: C
authors: Nierras
authors: Teo
authors: T
authors: Staeva
authors: John S
authors: JS
authors: Kaddis
authors: Martha
authors: M
authors: Campbell-Thompson
authors: Mark A
authors: MA
authors: Atkinson
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000502:physiology; D003299:Cooperative Behavior; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000821:virology; D005260:Female; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology / Q000473:pathology; D016035:Pancreas Transplantation; D012038:Regeneration; D014015:Tissue Banks; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D001323:Autoantibodies
keywords: TID; beta cell; organ donation; pancreas; virus