title: Importance of sulfonamide moiety in current and future therapy.
abstract: Sulfonamides and their different derivatives are extensively used in therapy due to their pharmacological properties. Sulfa drugs were amongst the oldest synthesized antimicrobial agents and are still widely used today to treat different microbial infections. Clinical treatment with sulfonamides has regained confidence with the use of a combination of sulfamethoxazole and trimethoprim to treat urinary tract bacterial infections. Today, they are widely used as antimicrobial agents, chiefly because of their low cost, low toxicity and excellent activity against bacterial diseases. Over the course of time, the application of sulfonamides has been extended from their use as antimicrobial agents to anticancer agents, antiglaucoma agents, inhibitors of gamma-secretase, cyclooxgenase-2 and lipoxygenase, anticonvulsivant agents, hypoglycemic agents.
authors: Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa"- Iaşi.
authors: Oana Maria
authors: OM
authors: Parasca
authors: Florentina
authors: F
authors: Gheaţă
authors: Andreea
authors: A
authors: Pânzariu
authors: Ioana
authors: I
authors: Geangalău
authors: Lenuţa
authors: L
authors: Profire
mesh_terms: D000890:Anti-Infective Agents / Q000191:economics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000191:economics; D004358:Drug Therapy / Q000191:economics / Q000639:trends; D006801:Humans; D012383:Romania; D013449:Sulfonamides / Q000191:economics / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D013449:Sulfonamides; D015662:Trimethoprim, Sulfamethoxazole Drug Combination