title: The effect of antireflux therapy on phonomicrosurgical outcomes: a preliminary retrospective study.
abstract: OBJECTIVE
  Currently, no clinical standards exist with regard to antireflux medications in the perioperative period for patients undergoing surgery for benign vocal fold lesions. The present study sought to determine the clinical yield of these medications on operative outcomes in patients who underwent surgical treatment for benign vocal fold lesions.
  
  
  METHODS
  Retrospective, outcomes study.
  
  
  METHODS
  Medical records were reviewed from a single surgeon database between January 2011 and June 2012 to quantify outcomes in patients taking antireflux medications compared with subjects not taking medications at the time of surgery. Voice Handicap Index (VHI)-10 and Reflux Symptom Index (RSI) scores were the primary dependent variables. The t test analyses were conducted to compare VHI-10 and RSI scores. Additional multivariate regression analyses were conducted to evaluate medication effects on VHI and RSI, adjusting for potential confounds.
  
  
  RESULTS
  A total of 51 patients met inclusion criteria. Of these patients, 12 (23.5%) were using antireflux medication(s) at the time of surgery and 39 (76.5%) were not. The mean shifts in VHI-10 and RSI after surgery for the antireflux therapy (ART) group were -14.75 and -7.5, respectively. For the non-antireflux therapy (non-ART) group, mean ΔVHI-10 and ΔRSI values were -9.87 and -5.05, respectively. Both t test and regression analyses confirmed no statistical difference between the ART and non-ART groups for both ΔVHI-10 and ΔRSI. Additional regression analysis revealed a positive correlation between preoperative RSI score and ΔRSI score.
  
  
  CONCLUSIONS
  Antireflux medications did not significantly alter postoperative outcomes in this preliminary cohort of patients.
authors: Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine, New York, New York.
authors: Ryan
authors: R
authors: Ruiz
authors: Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine, New York, New York.
authors: Stratos
authors: S
authors: Achlatis
authors: Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine, New York, New York.
authors: Shaum
authors: S
authors: Sridharan
authors: Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, New York.
authors: Binhuan
authors: B
authors: Wang
authors: Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, New York.
authors: Yixin
authors: Y
authors: Fang
authors: Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine, New York, New York. Electronic address: ryan.branski@nyumc.org.
authors: Ryan C
authors: RC
authors: Branski
authors: Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine, New York, New York.
authors: Milan R
authors: MR
authors: Amin
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D055154:Dysphonia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008866:Microsurgery / Q000009:adverse effects; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D020127:Recovery of Function; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery*; D014833:Voice Quality / Q000187:drug effects; D055815:Young Adult
chemical_list: D005765:Gastrointestinal Agents
keywords: Dysphonia; Laryngopharyngeal reflux; Phonomicrosurgery; Voice