title: Differing effects of liraglutide on gastric emptying in Japanese patients with type 2 diabetes.
abstract: This study was performed to clarify the influence of liraglutide on gastric emptying in Japanese patients with type 2 diabetes. In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment. We found two patterns of response, with gastric emptying being delayed by liraglutide in seven patients (delayers) and not delayed in nine patients (non-delayers). The mean increase of the maximum gastric emptying time was 31 ± 4 min (p < 0.01 vs. baseline) in the delayers, while it was only 2 ± 3 min (p = 0.60 vs. baseline) in the non-delayers. The delayers showed a greater early decrease of AUC-PG from 0 to 60 min, despite no increase of the plasma insulin level compared with non-delayers. In conclusion, the effect of liraglutide treatment on gastric emptying shows heterogeneity, and patients can be classified as delayers or non-delayers.
authors: Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors: Y
authors: Y
authors: Nagai
authors: E
authors: E
authors: Hashimoto
authors: R
authors: R
authors: Oikawa
authors: S
authors: S
authors: Asai
authors: Y
authors: Y
authors: Terashima
authors: Y
authors: Y
authors: Nakamura
authors: Y
authors: Y
authors: Sasaki
authors: H
authors: H
authors: Tsukiyama
authors: H
authors: H
authors: Fukuda
authors: T
authors: T
authors: Ohshige
authors: H
authors: H
authors: Kato
authors: A
authors: A
authors: Ohta
authors: Y
authors: Y
authors: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects; D001944:Breath Tests; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D052216:Glucagon-Like Peptide 1 / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000069450:Liraglutide; D008297:Male; D008875:Middle Aged; D013618:Tachyphylaxis
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1
keywords: breath test; delayers; gastric emptying; liraglutide; non-delayers; type 2 diabetes