title: The clinical impact of the sum of the maximum standardized uptake value on the pretreatment with F-FDG-PET/CT in small-cell lung cancer.
abstract: OBJECTIVE
  The aim of this study was to investigate the clinical significance of the sum of the maximum standardized uptake value (sumSUVmax) on pretreatment positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in newly diagnosed small-cell lung cancer (SCLC).
  
  
  METHODS
  We retrospectively analyzed 145 SCLC patients from March 2005 to June 2013 who underwent pretreatment (18)F-FDG-PET/CT. The sumSUVmax was assessed in all malignant lesions up to a maximum of 5 lesions and a maximum of 2 lesions per organ according to RECIST 1.1.
  
  
  RESULTS
  A significant difference was found between the low and high sumSUVmax groups (low vs. high sumSUVmax, 91.5 vs. 77.3%; p = 0.018) in the response rate (RR) following frontline platinum-based chemotherapy. The group with low sumSUVmax showed significantly better overall survival (OS; p < 0.001) as well as better progression-free survival (PFS; p < 0.001) compared with the group with high sumSUVmax. Moreover, multivariate analysis revealed that a high sumSUVmax alone was an independent poor prognostic factor for OS (hazard ratio 2.676; 95% confidence interval, 1.674-4.277; p < 0.001).
  
  
  CONCLUSIONS
  This study showed that the sumSUVmax adopted from RECIST 1.1 on pretreatment (18)F-FDG PET/CT was significantly correlated with response to treatment, OS, and PFS in patients with SCLC.
authors: Division of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors: Se-Il
authors: SI
authors: Go
authors: Haa-Na
authors: HN
authors: Song
authors: Jung-Hun
authors: JH
authors: Kang
authors: Myung Hee
authors: MH
authors: Kang
authors: Moon Jin
authors: MJ
authors: Kim
authors: Jaehoon
authors: J
authors: Jung
authors: Soon Il
authors: SI
authors: Chung
authors: Bong-Hoi
authors: BH
authors: Choi
authors: In-Gyu
authors: IG
authors: Hwang
authors: Seok-Hyun
authors: SH
authors: Kim
authors: Hui
authors: H
authors: Ling
authors: Gyeong-Won
authors: GW
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging* / Q000401:mortality
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18