title: Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations.
abstract: OBJECTIVE
  To determine interleukin (IL)-17 concentrations in serum and synovial fluid from patients with knee osteoarthritis, and evaluate their correlation with disease severity.
  
  
  METHODS
  Serum and synovial fluid were collected from patients with primary knee osteoarthritis; age- and sex-matched healthy control subjects provided serum samples. This study was conducted retrospectively. IL-17 was quantified by enzyme-linked immunosorbent assay. Osteoarthritis severity and grade were assessed using the Lequesne index and Kellgren and Lawrence (KL) grading system, respectively.
  
  
  RESULTS
  Serum IL-17 concentrations were significantly higher in patients (n = 98) than in controls (n = 50). In the patient group, the synovial fluid IL-17 concentration increased significantly with KL grade and was significantly positively correlated with Lequesne index (r = 0.6232).
  
  
  CONCLUSIONS
  The synovial fluid IL-17 concentration could represent a useful biochemical marker to reflect knee osteoarthritis severity and progression.
authors: Department of Orthopaedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors: Biao
authors: B
authors: Chen
authors: Yu
authors: Y
authors: Deng
authors: Yang
authors: Y
authors: Tan
authors: Jun
authors: J
authors: Qin
authors: Liao-Bin
authors: LB
authors: Chen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D020381:Interleukin-17
keywords: Interleukin 17; knee; osteoarthritis; plasma; synovial fluid