title: CX3CL1 at the crossroad of EGF signals: Relevance for the progression of ERBB2+breast carcinoma.
abstract: Inflammatory mediators can play a dual role in oncogenesis and tumor progression. CX3CL1, a chemokine previously implicated in natural killer cell- and CD8+T cell-mediated antitumor immune responses, has now been identified as a promoter of ERBB2-expressing breast carcinomas as it cross-activates members of the epidermal growth factor receptor family.
authors: Department of Immunology and Oncology; Centro Nacional de Biotecnología/CSIC; Madrid, Spain.
authors: Manuel
authors: M
authors: Tardáguila
authors: Santos
authors: S
authors: Mañes
keywords: ERK; MAPK; chemokine; cross-activation; fractalkine; inflammation; tumor promotion