title: Evaluation of weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with the rs6923761 gene variant of glucagon-like peptide 1 receptor.
abstract: BACKGROUND
  The role of glucagon-like peptide-1 receptor (GLP-1R) variants on body weight response after dietary intervention has not been evaluated so far.
  
  
  OBJECTIVE
  Our aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs6923761.
  
  
  METHODS
  A sample of 280 obese subjects was randomized to two hypocaloric diets.
  
  
  RESULTS
  124 patients (44.3%) had the genotype GG (wild-type) and 156 (55.7%) had another genotype (mutant), i.e. GA (n = 132, 47.1%) or AA (n = 24, 8.6%). With the type I diet (low in carbohydrates) in the wild-type and mutant groups, BMI, weight, fat mass, waist circumference, insulin levels, insulin resistance and triglycerides decreased. Anthropometric parameters were higher in non-A-allele carriers than A-allele carriers. With the type II diet (low in fats) in all genotypes, BMI, weight, fat mass, waist circumference, insulin levels, total cholesterol and LDL cholesterol decreased.
  
  
  CONCLUSIONS
  Our data showed better anthropometric parameters in obese subjects with the mutant allele (A) of the rs6923761 GLP-1R polymorphism. A lack of association of this polymorphism with weight loss or biochemical parameters after two different hypocaloric diets was observed.
authors: Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
authors: Daniel Antonio
authors: DA
authors: de Luis
authors: Rocío
authors: R
authors: Aller
authors: Olatz
authors: O
authors: Izaola
authors: Beatriz
authors: B
authors: de la Fuente
authors: David
authors: D
authors: Primo
authors: Rosa
authors: R
authors: Conde
authors: Manuel González
authors: MG
authors: Sagrado
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics; D011110:Polymorphism, Genetic; D018027:Receptors, Glucagon / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss / Q000235:genetics*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D007328:Insulin; D018027:Receptors, Glucagon; D014280:Triglycerides; D002784:Cholesterol