title: [The assessment of glucose and lipid parameters in children with a positive family history of hypertension].
abstract: Arterial hypertension in adults is often associated with excess body weight, and lipid or carbohydrate disorders. The incidence of hypertension in children is growing, although its connection with metabolic disorders and family history of hypertension has not been previously understood.
  
  
  OBJECTIVE
  To evaluate the relationship between a family history of hypertension and metabolic parameters (carbohydrate and lipid metabolism) and anthropometric measurements in children and adolescents.
  
  
  METHODS
  The study group consists of 40 children (mean age 13.6 years +/-2.7 years) with a positive family history of hypertension, and a comparative group of 44 children with a negative family history of hypertension. Anthropometric measurements, blood pressure, plasma insulin, glucose, homeostasis model assessment insulin resistants (HOMA IR), and lipid profiles were determined in all children.
  
  
  RESULTS
  Body weight, BMI, WHR, and measurements of skinfolds did not differ significantly between the groups. Systolic blood pressure was significantly higher in the study group (108 vs. 100 Me mmgHg, p = 0.031) Significant differences were observed in the levels of glucose (80 vs. Me. 67 mg/dl, p < 0.001), and insulin (8.89 vs. Me. 5.34 microIU / ml, p = 0.024). The HOMA index showed values significantly higher in the study group (1.68 vs. 0.80 Me p = 0.007). Children with a positive family history of hypertension were characterized by insignificantly higher values of total cholesterol, TG, LDL-cholesterol, and lower HDL-cholesterol.
  
  
  CONCLUSIONS
  A positive family history of hypertension correlates with higher systolic blood pressure and changes in carbohydrate metabolism parameters in the direction of the development of insulin resistance in children.
authors: Department of Family Medicine and Community Nursing, Medical University of Bialystok. anna.gryko@umb.edu.pl
authors: Anna
authors: A
authors: Gryko
authors: Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok.
authors: Barbara
authors: B
authors: Glowińska-Olszewska
authors: Department of Family Medicine and Community Nursing, Medical University of Bialystok.
authors: Katarzyna
authors: K
authors: Pludowska
authors: Department of Family Medicine and Community Nursing, Medical University of Bialystok.
authors: Anna
authors: A
authors: Owlasiuk
authors: Department of Paediatric Laboratory Diagnostics, Medical University of Bialystok.
authors: Beata
authors: B
authors: Elazowska-Rutkowska
authors: Department of Statistics and Medical Informatics, Medical University of Bialystok.
authors: Robert
authors: R
authors: Milewski
authors: Department of Family Medicine and Community Nursing, Medical University of Bialystok.
authors: Joanna
authors: J
authors: Szelag
authors: Department of Family Medicine and Community Nursing, Medical University of Bialystok.
authors: Slawomir
authors: S
authors: Chlabicz
mesh_terms: D000293:Adolescent; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008487:Medical History Taking; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D005947:Glucose