title: Self-emulsifying drug delivery system and the applications in herbal drugs.
abstract: Herbal drugs have been used for thousands of years in the east and have had a recent resurgence in popularity among consumers in the west. However, most of herbal drug are poorly soluble and have hydrophobic properties and poor distribution, leading to reduced bioavailability and hence decreased treatment efficacy, requiring repeated administration or increased dose. In the past few decades, considerable attention has been focused on the development of self-emulsifying drug delivery system (SEDDS) for herbal drugs. SEDDS is isotropic and thermodynamically stable solutions consisting of oil, surfactant, co-surfactant and drug that can spontaneously form oil-in-water micro/nanoemulsion when mixed with water under gentle stirring. The formulation can be a viable alternative to classical formulations to take advantage of their lipophilic nature and to solve their problems of poor solubility, poor bioavailability, low oral absorption and instability. The mechanism of self-emulsification, solubility studies, construction of phase diagram, optimization and characterization of herbal drugs-loaded SEDDS formulation and in situ absorption evaluation of herbal drugs in rat intestine are presented in our article.
authors: Shandong Academy of Pharmaceutical Science , Jinan , PR China and.
authors: Lin
authors: L
authors: Zhang
authors: Lanying
authors: L
authors: Zhang
authors: Manhong
authors: M
authors: Zhang
authors: Yue
authors: Y
authors: Pang
authors: Zhaoming
authors: Z
authors: Li
authors: Aili
authors: A
authors: Zhao
authors: Jing
authors: J
authors: Feng
mesh_terms: D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004655:Emulsions; D007408:Intestinal Absorption; D008297:Male; D009821:Oils / Q000737:chemistry; D028321:Plant Preparations / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D004655:Emulsions; D009821:Oils; D028321:Plant Preparations; D013501:Surface-Active Agents
keywords: Herbal drugs; self-emulsifying drug delivery system