title: [Epigenetics and pain].
abstract: Chronic pain affects approximately 20 % of adults worldwide and is often associated with a decrease in the quality of life and various comorbidities. Conventional analgesic therapies are frequently insufficient and sometimes lead to severe side effects. Therefore, great efforts are still being made to elucidate the signalling pathways in pain and to develop new, safe and effective therapies. Epigenetic mechanisms which interfere with the regulation of gene expression are involved in the pathogenesis of several diseases and are gaining increasing impetus in medical research. As they are also involved in pain processing, a modulation of these mechanisms might represent a novel option for the therapy of pain patients.
authors: pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt a. M., Deutschland, e.niederberger@em.uni-frankfurt.de.
authors: E
authors: E
authors: Niederberger
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology*; D006657:Histones / Q000378:metabolism / Q000502:physiology; D006801:Humans; D010146:Pain / Q000503:physiopathology*; D059408:Pain Management; D012333:RNA, Messenger / Q000235:genetics / Q000502:physiology
chemical_list: D006657:Histones; D012333:RNA, Messenger; D004247:DNA