title: Glioblastoma, brain metastases and soft tissue sarcoma of extremities: candidate tumors for BNCT.
abstract: (10)B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for preferential (10)B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean (10)B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising targets for future BNCT research.
authors: Department of Radiotherapy and Radiation Oncology, Pilipps-University Marburg, Marburg, Germany. Electronic address: andrea.wittig@uni-due.de.
authors: Andrea
authors: A
authors: Wittig
authors: ESE Unit, Institute for Energy and Transport, Joint Research Centre, European Commission, Petten, The Netherlands.
authors: Raymond L
authors: RL
authors: Moss
authors: Department of Radiation Oncology, University Hospital Essen, NCTeam, University Duisburg-Essen, Essen, Germany.
authors: Wolfgang A G
authors: WA
authors: Sauerwein
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000493:pharmacokinetics*; D001896:Boron Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary*; D045744:Cell Line, Tumor; D005121:Extremities; D005909:Glioblastoma / Q000378:metabolism* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012509:Sarcoma / Q000378:metabolism* / Q000532:radiotherapy; D013438:Sulfhydryl Compounds / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D001894:Borohydrides; D001896:Boron Compounds; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D010649:Phenylalanine; C033685:4-boronophenylalanine
keywords: (10)B biodistribution; BPA; BSH; Glioblastoma multiforme; Murine model; Soft tissue sarcoma