title: Topology-dependent swichability of peptide secondary structures in bioconjugates with complex architectures.
abstract: Peptide sequences, which exhibit a reversible pH-responsive coil to α-helix secondary structure transition, are conjugated to polymer precursors to yield linear AB and graft ABA peptide-poly(ethylene oxide) conjugates. While the PEO B-block is comparable, the conjugates differ in topologies of the peptide bearing A-blocks. The influences of topology on the structure transitions in the peptide segments are investigated, comparing linear AB-bioconjugates with graft ABA-bioconjugates having multiple peptide segments combined in star or pom-pom topologies.
authors: Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, D-12489, Berlin, Germany.
authors: Hans G
authors: HG
authors: Börner
authors: Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, D-12489, Berlin, Germany.
authors: Romina I
authors: RI
authors: Sütterlin
authors: University of Mainz, Institute of Organic Chemistry, Duesbergweg 10-14, D-55099, Mainz, Germany.|University of Hamburg, Institute for Technical and Macromolecular Chemistry, Bundesstr 45, D-20146, Hamburg, Germany.
authors: Patrick
authors: P
authors: Theato
authors: University of Mainz, Institute of Organic Chemistry, Duesbergweg 10-14, D-55099, Mainz, Germany.
authors: Kerstin T
authors: KT
authors: Wiss
mesh_terms: D018625:Microscopy, Atomic Force; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides; D011092:Polyethylene Glycols
keywords: bioconjugates; controlled radical polymerization; peptides; responsive polymers; self-assembly