title: Rose-bengal-conjugated gold nanorods for in vivo photodynamic and photothermal oral cancer therapies.
abstract: Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532 nm green light and high photothermal efficiency under 810 nm near-infrared (NIR) irradiation. In vitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. In vivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment.
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology, Hubei-MOST & Key Laboratory of Oral Biomedicine of Ministry of Education, Department of Periodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
authors: Beike
authors: B
authors: Wang
authors: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors: Jia-Hong
authors: JH
authors: Wang
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology, Hubei-MOST & Key Laboratory of Oral Biomedicine of Ministry of Education, Department of Periodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
authors: Qian
authors: Q
authors: Liu
authors: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
authors: Hao
authors: H
authors: Huang
authors: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors: Ming
authors: M
authors: Chen
authors: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors: Kaiyang
authors: K
authors: Li
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology, Hubei-MOST & Key Laboratory of Oral Biomedicine of Ministry of Education, Department of Periodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address: l56cz@hotmail.com.
authors: Chengzhang
authors: C
authors: Li
authors: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address: yxf@whu.edu.cn.
authors: Xue-Feng
authors: XF
authors: Yu
authors: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address: paul.chu@cityu.edu.hk.
authors: Paul K
authors: PK
authors: Chu
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D006224:Cricetinae; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D020287:In Situ Nick-End Labeling; D008297:Male; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000628:therapy*; D043942:Nanotubes / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017382:Reactive Oxygen Species / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D017382:Reactive Oxygen Species; D006046:Gold
keywords: Gold nanorods; Oral cancer; Photodynamic therapy; Photothermal therapy; Rose bengal