title: Change in urinary N-acetyl-β-d-glucosaminidase levels relevant to postprandial glycemic control conditions in subjects without diabetes mellitus.
abstract: BACKGROUND
  To assess the relationship between the serum level of 1,5-anhydroglucitol (1,5-AG), a marker of postprandial hyperglycemia, and the ratio of the urinary activity of N-acetyl-β-d-glucosaminidase to creatinine (NAG index) in subjects without diabetes mellitus (DM).
  
  
  METHODS
  This was a cross-sectional study with 495 subjects without DM who had an estimated glomerular filtration rate≥30ml/min/1.73m(2). Subjects were divided into tertiles based on serum 1,5-AG levels: high (>21.0μg/ml), middle (14.0-21.0μg/ml), and low (<14.0μg/ml). Adjusted odds ratios for an elevated urinary NAG index (>5.8U/g creatinine) according to the HbA1c (≤5.4%, 5.5%-5.9%, and 6.0%-6.4%) and 1,5-AG tertiles were calculated.
  
  
  RESULTS
  The NAG index was negatively correlated with the serum 1,5-AG level in all subjects. The slopes of the regression lines for these variables did not differ significantly between elderly (≥65y) and nonelderly subjects. As compared with high 1,5-AG and HbA1c≤5.4%, the odds ratios for an elevated urinary NAG index increased progressively to 7.71 across the categories of low 1,5-AG and HbA1c of 6.0% to 6.4%.
  
  
  CONCLUSIONS
  Poor control of postprandial glucose is related to an elevated urinary NAG index in persons without DM.
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan. Electronic address: otoshi@nms.ac.jp.
authors: Motoshi
authors: M
authors: Ouchi
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan; Department of Internal Medicine, Oarai Sea Shore Core Clinic, Ibaraki, Japan.
authors: Kenzo
authors: K
authors: Oba
authors: Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan.
authors: Makoto
authors: M
authors: Ohara
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Yoshimasa
authors: Y
authors: Igari
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Shoko
authors: S
authors: Futami-Suda
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Kazuhito
authors: K
authors: Ishii
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Junya
authors: J
authors: Aoyama
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Tetsuro
authors: T
authors: Onishi
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Misako
authors: M
authors: Tsunoda-Kubota
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Hidetoshi
authors: H
authors: Yamashita
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Tatsuya
authors: T
authors: Suzuki
authors: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Nakano
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003404:Creatinine / Q000652:urine; D003847:Deoxyglucose / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose; D003404:Creatinine; D000118:Acetylglucosaminidase
keywords: 1,5-anhydroglucitol; Impaired glucose tolerance; N-acetyl-β-d-glucosaminidase; Postprandial hyperglycemia; Renal tubular damage; Renal tubular injury