title: A study on the protective effect of Silybum marianum extract on hepatic ischemia-reperfusion injury.
abstract: The objective of the study was to study the protective effect of Silybum marianum extract on hepatic ischemia-reperfusion injury. Rats were randomly divided into five groups; namely Silybum marianum extract high-, medium-, and low-dose protection groups, model group and control group. Hepatic ischemia-reperfusion injury model was prepared. Serum or plasma AST, ALT, MDA, TNF-α, IL-1β, IL-6 levels were measured. The results revealed that after liver injury, AST, ALT, MDA, TNF-α, IL-1β, and IL-6 levels significantly increased in succession, showing significant differences. We concluded that inflammatory cytokines participate in liver injury and that Silybum marianum extract can reduce the production of inflammatory cytokines, and thus can have a protective effect on hepatic ischemia and reperfusion.
authors: Department of Digestion Medicine, The Third Affiliated Hospital of Xiang Ya School of Medicine, Central South University, Changsha 410078, Hunan, People's Republic of China.
authors: Shaojun
authors: S
authors: Liu
authors: Zhiheng
authors: Z
authors: Chen
authors: Dongbo
authors: D
authors: Cao
authors: Fen
authors: F
authors: Liu
authors: Xiaoyan
authors: X
authors: Wang
authors: Lian
authors: L
authors: Zhao
authors: Rui
authors: R
authors: Liu
authors: Zhiming
authors: Z
authors: Xiao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007511:Ischemia / Q000097:blood / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D020944:Silybum marianum; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000097:blood / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D016207:Cytokines; D010936:Plant Extracts; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Silybum marianum; hepatic ischemia-reperfusion injury; protective effect