title: Patch testing with formaldehyde 2.0% in parallel with 1.0% by the Swedish contact dermatitis research group.
abstract: In a multicentre study consecutively patch-tested dermatitis patients were tested simultaneously with 1.0% and 2.0% (w/v) formaldehyde in aqua applied with a micropipette (15 µl) to the filter paper disc in Finn Chambers (0.30 mg/cm(2) and 0.60 mg/cm(2), respectively). A total of 2,122 dermatitis patients were patch-tested. In all, 77 (3.6%) patients reacted positively to formaldehyde; 37 reacted only to 2.0%, 35 reacted to both concentrations and 5 patients reacted only to 1.0%. Significantly more patients were thus diagnosed with contact allergy to formaldehyde with 2.0% compared to 1.0% (p < 0.001) without causing more irritant reactions. The detected number of isolated allergic reactions to the 2 formaldehyde-releasers in the Swedish baseline series and not to formaldehyde itself raises the question whether quaternium-15 1.0% and diazolidinyl urea 2.0% should be present in the Swedish baseline series.
authors: Department of Occupational and Environmental Dermatology, Skåne University Hospital, 205 02 Malmö, Sweden. marlene.isaksson@skane.se, marlene.isaksson@med.lu.se.
authors: Marléne
authors: M
authors: Isaksson
authors: Johanna
authors: J
authors: Bråred-Christensson
authors: Malin
authors: M
authors: Engfeldt
authors: Magnus
authors: M
authors: Lindberg
authors: Mihaly
authors: M
authors: Matura
authors: Halvor
authors: H
authors: Möller
authors: Kristina
authors: K
authors: Ryberg
authors: Berndt
authors: B
authors: Stenberg
authors: Cecilia
authors: C
authors: Svedman
authors: Magnus
authors: M
authors: Bruze
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000008:administration & dosage; D002648:Child; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011237:Predictive Value of Tests; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage; D012867:Skin / Q000276:immunology* / Q000473:pathology; D023422:Skin Irritancy Tests; D013548:Sweden; D055815:Young Adult
chemical_list: D000485:Allergens; D011310:Preservatives, Pharmaceutical; D005557:Formaldehyde