title: [Epithelioid hemangioma: a clinicopathologic analysis of 7 cases].
abstract: OBJECTIVE
  To study the clinicopathologic features, diagnosis and differential diagnosis of epithelioid hemangioma.
  
  
  METHODS
  The morphologic features of 7 cases of epithelioid hemangioma of skin, bone and venous vessels were studied.
  
  
  RESULTS
  There were altogether 4 male and 3 female patients (median age = 34 years; age range from 14 to 54 years). The 3 skin cases presented as single or multiple erythematous to bluish nodules or papules, with or without itchiness. The 2 bone cases appeared as osteolytic expansile lesions on radiologic examination. The remaining 2 cases involved medium-sized venous structures and presented as small isolated nodules in soft tissue. Histologically, the lesions were characterized by the presence of exuberant endothelial proliferations with various degree of inflammatory reaction. The neoplastic endothelial cells were plump, eosinophilic and polygonal, forming vascular channels. Occasional solid sheet-like arrangement was demonstrated. Intracytoplasmic vacuoles were commonly identified, indicating formation of primary lumen. The surrounding stroma contained various number of eosinophils and lymphoplasmacytic cells. Immunohistochemical study showed that the tumor cells were positive for endothelial markers (CD31 and CD34) and negative for epithelial marker (cytokeratin). Follow-up information was available in 6 cases. The duration of follow-up ranged from 5 to 36 months (median = 14 months). There was no evidence of recurrence or distant metastasis.
  
  
  CONCLUSIONS
  Epithelioid hemangioma is a rare benign curable lesion which can be multifocal, involving skin, soft tissue and bone. It needs to be distinguished from Kimura's disease and epithelioid hemangioendothelioma.
authors: Department of Pathology, First Affiliated Hospital to Nanjing Medical University, Nanjing 210029, China.
authors: Qi-xing
authors: QX
authors: Gong
authors: Qin-he
authors: QH
authors: Fan
authors: Jun
authors: J
authors: Xie
authors: Zhong-lan
authors: ZL
authors: Su
authors: Mei-hua
authors: MH
authors: Zhang
authors: Zhi-hong
authors: ZH
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000473:pathology; D018952:Antigens, CD34 / Q000378:metabolism; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D018323:Hemangioendothelioma, Epithelioid / Q000473:pathology; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1