title: Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers.
abstract: In this study, we select naproxen (NAP) as a reference drug and electrospun poly (ɛ-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
authors: UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey; Suleyman Demirel University, Engineering Faculty, Textile Engineering, Isparta 32260, Turkey. Electronic address: fatihcanbolat@sdu.edu.tr.
authors: M Fatih
authors: MF
authors: Canbolat
authors: UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey; Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey.
authors: Asli
authors: A
authors: Celebioglu
authors: UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey; Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey. Electronic address: tamer@unam.bilkent.edu.tr.
authors: Tamer
authors: T
authors: Uyar
mesh_terms: D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009288:Naproxen / Q000494:pharmacology*; D011091:Polyesters / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D011091:Polyesters; D047392:beta-Cyclodextrins; C016240:polycaprolactone; D009288:Naproxen; C031215:betadex
keywords: Cyclodextrin; Drug; Inclusion complex; Nanofibers; Naproxen; Release