title: Idiopathic granulomatous interstitial nephritis responsive to mycophenolate mofetil therapy.
abstract: Granulomatous interstitial nephritis (GIN) is a rare histologic disease. Various causes have been reported in the literature, including drugs, sarcoidosis, and infections. Other incidents have no discernible cause and are identified as idiopathic. We report a 68-year-old white man who presented with acute kidney injury and was given a diagnosis of idiopathic GIN. Mycophenolate mofetil treatment was elected because of steroid toxicity. He responded well to mycophenolate mofetil and has been in remission for more than 3 years. To our knowledge, this is the first report of successful treatment with mycophenolate mofetil of an adult patient with idiopathic GIN.
authors: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY. Electronic address: napat.leeaphorn@bassett.org.
authors: Napat
authors: N
authors: Leeaphorn
authors: Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY.
authors: Michael B
authors: MB
authors: Stokes
authors: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY.
authors: Patompong
authors: P
authors: Ungprasert
authors: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY.
authors: William
authors: W
authors: Lecates
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D005938:Glucocorticoids / Q000008:administration & dosage; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction; D017211:Treatment Failure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D003404:Creatinine; D009173:Mycophenolic Acid; D008775:Methylprednisolone
keywords: Granulomatous interstitial nephritis (GIN); mycophenolate mofetil