title: Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia.
abstract: OBJECTIVE
  Assess the impact of intercurrent respiratory infections in infants <29 weeks gestational age (GA).
  
  
  METHODS
  A retrospective cohort study of 111 infants born <29 weeks GA, controlling for bronchopulmonary dysplasia (BPD) severity and assessing pulmonary health over the first year of life through oxygen, diuretic and inhaled steroid use.
  
  
  RESULTS
  Regression analysis showed viral infections increased oxygen use (odds ratio (OR) of 15.5 (confidence interval (CI)=3.4, 71.3)). The trend test showed increasing numbers of viral infections were associated with increased oxygen (OR (95% CI)=6.4 (2.3 to 17.4), P=0.0003), diuretic (OR (95% CI)=2.4 (1.1to 5.2), P=0.02) and inhaled steroid use (OR (95% CI)=2.2 (1.003 to 5.2), P=0.049), whereas bacterial infections were not.
  
  
  CONCLUSIONS
  Viral infections caused more long-term pulmonary morbidity/mortality than bacterial infections on premature lung health, even when controlling for BPD.
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: J B
authors: JB
authors: Taylor
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: M F
authors: MF
authors: Nyp
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: M
authors: M
authors: Norberg
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: H
authors: H
authors: Dai
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: H
authors: H
authors: Escobar
authors: Department of Preventative Medicine, University of Kansas Medical Center, Kansas, MO, USA.
authors: E
authors: E
authors: Ellerbeck
authors: Center for Infant Pulmonary Disorders, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA.
authors: W E
authors: WE
authors: Truog
mesh_terms: D000280:Administration, Inhalation; D001424:Bacterial Infections / Q000150:complications*; D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D016015:Logistic Models; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000706:statistics & numerical data; D012141:Respiratory Tract Infections / Q000150:complications*; D012189:Retrospective Studies; D013256:Steroids / Q000627:therapeutic use*; D014777:Virus Diseases / Q000150:complications*
chemical_list: D004232:Diuretics; D013256:Steroids