title: Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.
authors: Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Salome
authors: S
authors: Scholtens
authors: Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Dirkje S
authors: DS
authors: Postma
authors: Division of Respiratory Sciences, Imperial College, London, United Kingdom.
authors: Miriam F
authors: MF
authors: Moffatt
authors: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors: Sviatlana
authors: S
authors: Panasevich
authors: ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
authors: Raquel
authors: R
authors: Granell
authors: ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
authors: A John
authors: AJ
authors: Henderson
authors: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Sachs' Children's Hospital, Stockholm, Sweden.
authors: Erik
authors: E
authors: Melén
authors: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Global Epidemiology, AstraZeneca R&D, Mölndal, Sweden.
authors: Fredrik
authors: F
authors: Nyberg
authors: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors: Göran
authors: G
authors: Pershagen
authors: Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
authors: Deborah
authors: D
authors: Jarvis
authors: Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
authors: Adaikalavan
authors: A
authors: Ramasamy
authors: Institute of Medical Statistics and Epidemiology (IMSE), Klinikum Rechts der Isar, Technical University, Munich, Germany; Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease (iLBD), Helmholtz Center Munich, Neuherberg, Germany.
authors: Matthias
authors: M
authors: Wjst
authors: Bergen Respiratory Research Group, Institute of Medicine, University of Bergen and Department of Occupational Medicine, Haukeland University Hospital Bergen, Bergen, Norway.
authors: Cecilie
authors: C
authors: Svanes
authors: Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
authors: Emmanuelle
authors: E
authors: Bouzigon
authors: Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
authors: Florence
authors: F
authors: Demenais
authors: Inserm U1018, CESP Centre for research in Epidemiology and Population Health, Respiratory and environmental epidemiology Team, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France.
authors: Francine
authors: F
authors: Kauffmann
authors: Inserm U823, Centre de Recherche Albert Bonniot, La Tronche, France; Université Joseph Fourier, Grenoble, France.
authors: Valérie
authors: V
authors: Siroux
authors: LMU Munich, University Children's Hospital, Munich, Germany.
authors: Erika
authors: E
authors: von Mutius
authors: LMU Munich, University Children's Hospital, Munich, Germany.
authors: Markus Johannes
authors: MJ
authors: Ege
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors: Charlotte
authors: C
authors: Braun-Fahrländer
authors: Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
authors: Jon
authors: J
authors: Genuneit
authors: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Bert
authors: B
authors: Brunekreef
authors: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors: Henriette A
authors: HA
authors: Smit
authors: Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors: Alet H
authors: AH
authors: Wijga
authors: Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Marjan
authors: M
authors: Kerkhof
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors: Ivan
authors: I
authors: Curjuric
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors: Medea
authors: M
authors: Imboden
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors: Gian A
authors: GA
authors: Thun
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors: Nicole
authors: N
authors: Probst-Hensch
authors: Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
authors: Maxim B
authors: MB
authors: Freidin
authors: Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
authors: Elena Iu
authors: EIu
authors: Bragina
authors: Siberian State Medical University, Tomsk, Russia.
authors: I A
authors: IA
authors: Deev
authors: Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia.
authors: V P
authors: VP
authors: Puzyrev
authors: James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Denise
authors: D
authors: Daley
authors: James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Julie
authors: J
authors: Park
authors: Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
authors: Allan
authors: A
authors: Becker
authors: Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Moira
authors: M
authors: Chan-Yeung
authors: Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada.
authors: Anita L
authors: AL
authors: Kozyrskyj
authors: James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Peter
authors: P
authors: Pare
authors: Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
authors: Ingo
authors: I
authors: Marenholz
authors: Pediatric Pneumology and Immunology, Charité-Medical University, Berlin, Germany.
authors: Susanne
authors: S
authors: Lau
authors: Institute of Social Medicine, Epidemiology and Health Economics, Charité-Medical University, Berlin, Germany.
authors: Thomas
authors: T
authors: Keil
authors: Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
authors: Young-Ae
authors: YA
authors: Lee
authors: Department of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
authors: Michael
authors: M
authors: Kabesch
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Cisca
authors: C
authors: Wijmenga
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Lude
authors: L
authors: Franke
authors: Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Ilja M
authors: IM
authors: Nolte
authors: Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Judith
authors: J
authors: Vonk
authors: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors: Ashish
authors: A
authors: Kumar
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors: Martin
authors: M
authors: Farrall
authors: Division of Respiratory Sciences, Imperial College, London, United Kingdom.
authors: William O C M
authors: WO
authors: Cookson
authors: Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom.
authors: David P
authors: DP
authors: Strachan
authors: Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Gerard H
authors: GH
authors: Koppelman
authors: Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: h.m.boezen@umcg.nl.
authors: H Marike
authors: HM
authors: Boezen
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D008840:Microfilament Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: C116887:EPB41L3 protein, human; D008840:Microfilament Proteins; D014028:Tobacco Smoke Pollution