title: [Clinical value of two methods to measure parathyroid hormone in chronic renal insufficiency, considering vitamin D metabolism].
abstract: BACKGROUND
  Parathyroid hormone levels provide important information in chronic renal failure.
  
  
  OBJECTIVE
  To compare parathyroid hormone levels measured by two assays in correlation with vitamin D supply.
  
  
  METHODS
  Parathyroid hormone and 25-hydroxi-vitamin-D were determined in 104 patients (31 patients with chronic renal failure without renal replacement therapy, 36 patients treated with peritoneal dialysis and 37 patients treated with hemodialysis).
  
  
  RESULTS
  Good correlation was found between results of the two parathyroid hormone methods, but the intact parathyroid hormone levels were higher than the biointact values. 87% and 13% of the patients had vitamin-D deficiency and insufficiency, respectively. The frequency of serious vitamin-D deficiency was higher in the peritoneal dialysis than in the hemodialysis group. Intact parathyroid hormone levels were different in dialysed patients having vitamin-D-deficiency and insufficiency, and the difference was higher for the biointact than intact values. Negative correlation was detected between biointact parathyroid hormone and 25-hydroxivitamin-D in the hemodialysis group.
  
  
  CONCLUSIONS
  Biointact parathyroid hormone levels better reflect the vitamin D supply and bone metabolism than intact levels, especially in hemodialysed patients.
authors: Markusovszky Lajos Egyetemi Oktató Kórház Általános Belgyógyászati Osztály Szombathely B. Braun Avitum Hungary Zrt. 6. sz. Dialízis Központ Szombathely.
authors: László
authors: L
authors: Kovács
authors: Markusovszky Lajos Egyetemi Oktató Kórház Általános Belgyógyászati Osztály Szombathely.
authors: Eva
authors: E
authors: Virágh
authors: Csolnoky Ferenc Kórház Központi Laboratórium Veszprém.
authors: Dóra
authors: D
authors: Balogh
authors: Markusovszky Lajos Egyetemi Oktató Kórház Kutatási és Oktatási Központ Szombathely.
authors: Bernadette
authors: B
authors: Kálmán
authors: Markusovszky Lajos Egyetemi Oktató Kórház Általános Belgyógyászati Osztály Szombathely.
authors: Zoltán
authors: Z
authors: Lőcsei
authors: Markusovszky Lajos Egyetemi Oktató Kórház Központi Laboratórium Szombathely Markusovszky u. 5. 9700 Pécsi Tudományegyetem, Egészségtudományi Kar Gyakorlati Diagnosztikai Tanszéki Csoport, Szombathelyi Képzési Központ Szombathely.
authors: Erzsébet
authors: E
authors: Toldy
mesh_terms: D000328:Adult; D000368:Aged; D001681:Biological Assay / Q000379:methods*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium
keywords: 25(OH)D-vitamin; 25(OH)vitamin D; PTH-biointakt assay; PTH-intakt; bio-intact PTH assay; intact PTH; renal osteodystrophy; renal replacement therapy; renalis osteodystrophia; vesepótló terápia