title: Polyurethane scaffold in lateral meniscus segmental defects: clinical outcomes at 24 months follow-up.
abstract: BACKGROUND
  Segmental tissue loss in the lateral meniscus is associated with pain and increased risk of osteoarthritis even when indications have been carefully considered.
  
  
  OBJECTIVE
  Repairing the defect using a novel biodegradable scaffold will reduce pain and restore the knee function.
  
  
  METHODS
  In this prospective multicenter study, a total of 54 patients (37 males/17 females; mean age: 28 years [16-50]) were enrolled. All patients presented with postmeniscectomy syndrome and segmental lateral meniscus loss, and were treated with a polyurethane biodegradable scaffold (Actifit(®), Orteq) implanted arthroscopically. Clinical outcomes were assessed at 6, 12 and 24 months using Visual Analogue Scale (VAS), International Knee Documentation Committee Score (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS).
  
  
  RESULTS
  VAS decreased from 5.5 at baseline to 3.6 at 6 months, 3.4 at 12 months and 2.9 at 24 months. IKDC improved from 47.0 at baseline to 60.2, 67.0 and 67.0 at 6, 12 and 24 months. All KOOS subscores improved between baseline and 24 months.
  
  
  CONCLUSIONS
  Clinical results of this study demonstrate clinically and statistically significant improvements of pain and function scores (VAS, IKDC, and all KOOS subscales except sport), at the 6 months follow-up and on all clinical outcomes at the 2-year follow-up. The Actifit(®) scaffold is safe and effective in treating lateral meniscus defects.
  
  
  METHODS
  continuous prospective multicenter study.
authors: Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France; Orthopaedic Surgery Center, 71, boulevard d'Anfa, Casablanca 20060, Morocco.
authors: H
authors: H
authors: Bouyarmane
authors: Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France. Electronic address: pbeaufils@ch-versailles.fr.
authors: P
authors: P
authors: Beaufils
authors: Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France.
authors: N
authors: N
authors: Pujol
authors: Catholic University Hospitals, Langdorp, Belgium.
authors: J
authors: J
authors: Bellemans
authors: Orthopaedic Hospital, Oswestry, United Kingdom.
authors: S
authors: S
authors: Roberts
authors: University Hospitals, Coventry, United Kingdom.
authors: T
authors: T
authors: Spalding
authors: Istituto Ortopedico Rizzoli, Bologna, Italy.
authors: S
authors: S
authors: Zaffagnini
authors: Istituto Ortopedico Rizzoli, Bologna, Italy.
authors: M
authors: M
authors: Marcacci
authors: Antwerpen Orthopaedic center, Antwerp, Belgium.
authors: P
authors: P
authors: Verdonk
authors: Orteq Sports Medicine, London, United Kingdom.
authors: M
authors: M
authors: Womack
authors: Ghent University Hospital, Ghent, Belgium.
authors: R
authors: R
authors: Verdonk
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008592:Menisci, Tibial / Q000601:surgery*; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods; D011140:Polyurethanes; D011446:Prospective Studies; D011474:Prosthesis Design; D013997:Time Factors; D054457:Tissue Scaffolds; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011140:Polyurethanes
keywords: Arthroscopy; Knee; Lateral meniscus; Meniscectomy; Scaffold