title: Development and characterization of nano-fiber patch for the treatment of glaucoma.
abstract: In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops.
authors: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
authors: Gagandeep
authors: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
authors: Tarun
authors: T
authors: Garg
authors: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
authors: Basant
authors: B
authors: Malik
authors: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
authors: Goutam
authors: G
authors: Rath
authors: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India. Electronic address: amitkumargoyal1979@gmail.com.
authors: Amit K
authors: AK
authors: Goyal
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005901:Glaucoma / Q000188:drug therapy*; D057139:Nanofibers / Q000008:administration & dosage*; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; C062765:dorzolamide
keywords: Draize test; Intraocular pressure; Mucoadhesive strength; Nano-fiber patch