title: HIV integration and T cell death: additional commentary.
abstract: Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here.
authors: Arik
authors: A
authors: Cooper
authors: Mayra
authors: M
authors: García
authors: Constantinos
authors: C
authors: Petrovas
authors: Takuya
authors: T
authors: Yamamoto
authors: Richard A
authors: RA
authors: Koup
authors: Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bldg, 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, MD 20892-3005, USA. Gary.Nabel@sanofi.com.
authors: Gary J
authors: GJ
authors: Nabel
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000473:pathology* / Q000821:virology*; D004249:DNA Damage; D051747:DNA-Activated Protein Kinase / Q000378:metabolism*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D011533:Proviruses / Q000472:pathogenicity*; D016662:Virus Integration
chemical_list: D051747:DNA-Activated Protein Kinase