title: Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.
abstract: OBJECTIVE
  To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity.
  
  
  METHODS
  A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats.
  
  
  RESULTS
  Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats.
  
  
  CONCLUSIONS
  Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.
authors: Center for Devices & Radiological Health, US FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
authors: Qin
authors: Q
authors: Zhang
authors: Kelly J
authors: KJ
authors: Davis
authors: Dana
authors: D
authors: Hoffmann
authors: Vishal S
authors: VS
authors: Vaidya
authors: Ronald P
authors: RP
authors: Brown
authors: Peter L
authors: PL
authors: Goering
mesh_terms: D000375:Aging; D000818:Animals; D015415:Biomarkers / Q000652:urine*; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D001835:Body Weight; D004195:Disease Models, Animal; D018450:Disease Progression; D006973:Hypertension / Q000150:complications*; D009765:Obesity / Q000150:complications*; D051381:Rats; D011918:Rats, Inbred SHR; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
chemical_list: D015415:Biomarkers