title: Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation.
abstract: Hematopoietic stem cell transplantation from a healthy donor (allo-HSCT) represents the most potent form of cellular adoptive immunotherapy to treat malignancies. In allo-HSCT, donor T cells are double edge-swords: highly potent against residual tumor cells, but potentially highly toxic, and responsible for graft versus host disease (GVHD), a major clinical complication of transplantation. Gene transfer technologies coupled with current knowledge on cancer immunology have generated a wide range of approaches aimed at fostering the immunological response to cancer cells, while avoiding or controlling GVHD. In this review, we discuss cell and gene therapy approaches currently tested in preclinical models and in clinical trials.
authors: University Vita-Salute San Raffaele, Milan, Italy; Experimental Hematology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, PIBIC, San Raffaele Scientific Institute, Milan, Italy.
authors: Nicoletta
authors: N
authors: Cieri
authors: Sara
authors: S
authors: Mastaglio
authors: Giacomo
authors: G
authors: Oliveira
authors: Monica
authors: M
authors: Casucci
authors: Attilio
authors: A
authors: Bondanza
authors: Chiara
authors: C
authors: Bonini
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment / Q000276:immunology; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D015316:Genetic Therapy; D006086:Graft vs Host Disease / Q000209:etiology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D014161:Transduction, Genetic; D014184:Transplantation, Homologous
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: CAR; TCR; adoptive cellular immunotherapy; allogeneic hematopoietic stem cell transplantation; gene therapy; suicide gene