title: Pityriasis rosea in a hepatitis B-positive patient treated with pegylated interferon α2a: report of a case and review of the literature.
abstract: Pityriasis rosea (PR) is an acute, self-limiting exanthematous disease caused by the endogenous reactivation of human herpesvirus (HHV)-6 and/or HHV-7 infection in conditions of altered immunity. In addition, many drugs have been incriminated as possible triggers of PR-like eruptions, characterized by clinical, morphological and histopathological features that differ from typical PR. Here, we report a case of PR in a patient with chronic hepatitis B, receiving pegylated interferon α2a (PEG-IFN-α2a). PR, arising after the second administration of the PEG-IFN-α2a, might be considered a clinical expression of the patient's altered immune condition as reported in the immune reconstitution inflammatory syndrome affecting patients with human immunodeficiency virus infection after high-dose antiretroviral therapy.
authors: Department of Endocrinological and Metabolic Sciences, Section of Dermatology, University of Genoa, Genoa, Italy.
authors: Francesco
authors: F
authors: Drago
authors: Sanja
authors: S
authors: Javor
authors: Linda
authors: L
authors: Bruzzone
authors: Francesca
authors: F
authors: Drago
authors: Aurora
authors: A
authors: Parodi
authors: Antonino
authors: A
authors: Picciotto
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D015654:Herpesvirus 6, Human / Q000502:physiology; D016199:Herpesvirus 7, Human / Q000502:physiology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced / Q000150:complications; D016898:Interferon-alpha / Q000009:adverse effects*; D017515:Pityriasis Rosea / Q000209:etiology*; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects; D014775:Virus Activation / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a