title: Littoral cell angioma of the spleen--a surprising cause of anemia.
abstract: Littoral cell angioma is a rare tumor of the spleen, usually being considered benign and typically discovered incidentally. There are three different modalities of presentation: tumoral splenomegaly, long-standing iron deficient anemia or thrombocytopenia due to hypersplenism. However, some of its manifestations could generate the suspicion of a lymphoma or other more serious condition. We present the case of a 46-year-old man with splenomegaly and iron deficiency anemia. The tumor affected the whole spleen, which was surgically removed. The histopathological examination, together with immunophenotyping, established the diagnosis. Six months after the procedure, the patient is in very good condition. Several differential diagnoses were discussed, as well as the prognostic factors. The case illustrates a rare cause of anemia and the importance of pathology in uncovering such unusual causes for this.
authors: "Stefan Berceanu" Center of Hematology and Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania; iuliaursuleac@yahoo.com.
authors: Iulia
authors: I
authors: Ursuleac
authors: Cristina
authors: C
authors: Iosif
authors: Rodica
authors: R
authors: Bîrlă
authors: Camelia
authors: C
authors: Dobrea
authors: Amelia Maria
authors: AM
authors: Găman
authors: D
authors: D
authors: Arsene
authors: D
authors: D
authors: Coriu
mesh_terms: D000740:Anemia / Q000000981:diagnostic imaging / Q000209:etiology*; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D006391:Hemangioma / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D013160:Splenic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C067980:CD68 antigen, human; D000097382:CD68 Molecule