title: Genetic association between NOD2 polymorphism and infection status by Mycobacterium avium ssp. paratuberculosis in German Holstein cattle.
abstract: The aim of the study was the analysis of the nucleotide-binding oligomerization domain containing 2 (NOD2, formerly CARD15) as a candidate gene for Mycobacterium avium ssp. paratuberculosis infection in cattle. Eleven SNPs in the NOD2 gene were identified, and finally, four SNPs were included in a case-control study using 324 German Holstein cows tested for paratuberculosis using fecal culture and ELISA. The SNP (GenBank) AY518738S04:g.521G>A in exon 4 showed a significant association between the fecal culture status of the animals and NOD2 allele variants. The other three SNPs showed no associations in German Holstein cows.
authors: Institut für Tierzucht und Haustiergenetik, Justus-Liebig-Universität, Gießen, 35390, Germany.
authors: J D
authors: JD
authors: Küpper
authors: H R
authors: HR
authors: Brandt
authors: G
authors: G
authors: Erhardt
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002417:Cattle / Q000235:genetics*; D002418:Cattle Diseases / Q000235:genetics* / Q000382:microbiology; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D016927:Mycobacterium avium subsp. paratuberculosis; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D010283:Paratuberculosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053473:Nod2 Signaling Adaptor Protein
keywords: CARD15; bovine; candidate gene; fecal culture; nucleotide-binding oligomerization domain containing 2; paratuberculosis