title: [Investigation of multyphytoadaptogene anti-radiation activity in mice].
abstract: The aim of the work was to elucidate the radioprotective activity of multyphytoadaptogene (MPA) in mice in various conditions of gamma radiation and MPA application. Males of CBA x C57BL/6 F1 mice were given 15% MPA solution with drinking water 2 weeks before the radiating (preventive application), 2 weeks before and 2 weeks after the radiating (preventive and therapeutic application) and also 2 weeks after the radiating only (therapeutic application). Animals of control groups received radiation or were given 5% ethanol solution in drinking water in the same application schemes. MPA increased the mice survival in preventive, preventive and therapeutic as well as therapeutic applications after 7.5 Gy radiation (66.7: 66.4 and 40.2% correspondingly). After 11.0 Gy radiation MPA increased the mice survival in preventive as well as preventive and therapeutic applications (75.0 and 76.9% correspondingly). MPA administration improved the somatic state, weight of animals, quality of life. MPA has no side effects. The data suggest the radioprotective activity of MPA.
authors: E V
authors: EV
authors: Bocharov
authors: R V
authors: RV
authors: Karpova
authors: I V
authors: IV
authors: Kazeev
authors: V G
authors: VG
authors: Kucheryanu
authors: O A
authors: OA
authors: Bocharova
mesh_terms: D000818:Animals; D000431:Ethanol / Q000627:therapeutic use; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D014916:Whole-Body Irradiation
chemical_list: D010936:Plant Extracts; D011837:Radiation-Protective Agents; D000431:Ethanol