title: Nitroxide-mediated radical ring-opening copolymerization: chain-end investigation and block copolymer synthesis.
abstract: Well-defined, degradable copolymers are successfully prepared by nitroxide-mediated radical ring opening polymerization (NMrROP) of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) or methyl methacrylate (MMA), a small amount of acrylonitrile (AN) and cyclic ketene acetals (CKAs) of different structures. Phosphorous nuclear magnetic resonance allows in-depth chain-end characterization and gives crucial insights into the nature of the copoly-mer terminal sequences and the living chain fractions. By using a small library of P(OEGMA-co-AN-co-CKA) and P(MMA-co-AN-co-CKA) as macroinitiators, chain extensions with styrene are performed to furnish (amphiphilic) block copolymers comprising a degradable segment.
authors: Institut Galien Paris-Sud, UMR CNRS 8612, Univ Paris-Sud, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296, Châtenay-Malabry cedex, France.
authors: Vianney
authors: V
authors: Delplace
authors: Simon
authors: S
authors: Harrisson
authors: Antoine
authors: A
authors: Tardy
authors: Didier
authors: D
authors: Gigmes
authors: Yohann
authors: Y
authors: Guillaneuf
authors: Julien
authors: J
authors: Nicolas
mesh_terms: D000181:Acrylonitrile / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry; D020366:Methylmethacrylate / Q000737:chemistry; D009589:Nitrogen Oxides / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005030:Ethylenes; D007659:Ketones; D008689:Methacrylates; D009589:Nitrogen Oxides; D011108:Polymers; D020366:Methylmethacrylate; D010758:Phosphorus; C039900:nitroxyl; C008223:ketene; D000181:Acrylonitrile
keywords: biodegradable; block copolymer; kinetics (polym.); living polymerization; nitroxide-mediated polymerization (NMP)