title: [Pharmacokinetics of the anterior eye].
abstract: The pharmacokinetics of the anterior eye comprises the application, resorption, bioavailability, metabolization and elimination of topically administered drugs. In addition to the necessity of the penetration of the substance through the naturally occurring barriers of the eye in the form of the tear film, cornea, conjunctiva and sclera, the correct technique for administration is necessary for an optimal effect of the drug. Several new application devices have been described in the literature but most are still in an experimental phase. The main aims are to increase drug exposure time to the anterior surface of the eye and decrease problems in administration. Furthermore, new preservative agents are in use in order to produce less toxic side effects.
authors: Augenklinik, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland, katharina.bell@unimedizin-mainz.de.
authors: K
authors: K
authors: Bell
authors: N
authors: N
authors: Pfeiffer
authors: F H
authors: FH
authors: Grus
mesh_terms: D060433:Administration, Ophthalmic; D000869:Anterior Eye Segment / Q000187:drug effects* / Q000378:metabolism*; D001682:Biological Availability; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D065587:Ocular Absorption / Q000502:physiology*; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D009883:Ophthalmic Solutions