title: [Fibrous papules of the face: a retrospective anatomoclinical study of 283 cases].
abstract: BACKGROUND
  Fibrous papules of the face are frequent benign lesions seen in the nasal and perinasal region. Their clinical aspect is indistinct and the histological signs are sometimes mild or possibly misleading in the case of atypical forms. We carried out a retrospective study of 283 fibrous papules diagnosed at our histology laboratory. The goal of this study was to characterize this type of frequent but occasionally unrecognized lesion.
  
  
  METHODS
  We performed a retrospective study of fibrous papules of the face diagnosed in the dermatopathology laboratory of our dermatology centre between January 2002 and December 2011. The study concerned the clinical information noted in the examination request and the morphological abnormalities seen at optical microscopy. An immunohistological study of factor XIIIa was performed in selected cases.
  
  
  RESULTS
  The fibrous papules of the face came from 129 men and 154 women aged between 18 and 90 years (mean: 46 years). Two hundred and thirty-seven (83.7%) lesions were taken from the nasal region and none were taken from anywhere other than the face. The clinically mentioned diagnoses varied. A diagnosis of fibrous papule of the face was stated in 42% of cases, and the main differential diagnoses were nevus (stated in 34% of cases) and basal cell carcinoma (stated in 14% of cases). The fibrous papules were classic in 85.5% of cases. We observed 6 variants of fibrous papule: hypercellular, inflammatory, pleomorphic, pigmented, clear-cell and granular-cell types. Immunohistochemistry of factor XIIIa was positive in all cases except clear-cell fibrous papules.
  
  
  CONCLUSIONS
  This study shows that despite their frequency, these lesions often go unrecognized, since the hypothesis of a fibrous papule of the face was mentioned in fewer than 50% of cases at the time of biopsy. Diagnosis is often made by the histopathologist, who may be misled by some rare types. The principal differential diagnoses are nevus and basal cell carcinoma, thus warranting methodical histological analysis of all pieces.
authors: Service de dermatologie, hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France. Electronic address: ghdcambourg@yahoo.fr.
authors: G
authors: G
authors: de Cambourg
authors: B
authors: B
authors: Cribier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D003094:Collagen / Q000032:analysis; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D026122:Factor XIIIa / Q000032:analysis; D005260:Female; D005355:Fibrosis; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000175:diagnosis; D009666:Nose / Q000473:pathology; D012189:Retrospective Studies; D017444:Skin Diseases, Papulosquamous / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis; D013194:Staining and Labeling; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003094:Collagen; D026122:Factor XIIIa
keywords: Angiofibroma; Angiofibrome; Dermatopathologie; Dermatopathology; Facteur XIIIa; Factor XIIIa; Fibrous papule; Papule fibreuse