title: Experimental infection of dogs with various Bartonella species or subspecies isolated from their natural reservoir.
abstract: Dogs can be infected by a wide variety of Bartonella species. However, limited data is available on experimental infection of dogs with Bartonella strains isolated from domestic animals or wildlife. We report the inoculation of six dogs with Bartonella henselae (feline strain 94022, 16S rRNA type II) in three sets of two dogs, each receiving a different inoculum dose), four dogs inoculated with B. vinsonii subsp. berkhoffii type I (ATCC strain, one mongrel dog) or type II (coyote strain, two beagles and one mongrel) and B. rochalimae (coyote strain, two beagles). None of the dogs inoculated with B. henselae became bacteremic, as detected by classical blood culture. However, several dogs developed severe necrotic lesions at the inoculation site and all six dogs seroconverted within one to two weeks. All dogs inoculated with the B. v. berkhoffii and B. rochalimae strains became bacteremic at levels comparable to previous experimental infections with either a dog isolate or a human isolate. Our data support that dogs are likely accidental hosts for B. henselae, just like humans, and are efficient reservoirs for both B. v. berkhoffii and B. rochalimae.
authors: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address: bbchomel@ucdavis.edu.
authors: Bruno B
authors: BB
authors: Chomel
authors: Division of Comparative Medicine, Animal Resources Center, Beckman Research Institute City of Hope, 1500 East Duarte Road, Duarte, CA 91010-3000, USA.
authors: Richard W
authors: RW
authors: Ermel
authors: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors: Rickie W
authors: RW
authors: Kasten
authors: Napa County Health and Human Services, Napa, CA, USA.
authors: Jennifer B
authors: JB
authors: Henn
authors: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors: Drew A
authors: DA
authors: Fleischman
authors: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.
authors: Chao-Chin
authors: CC
authors: Chang
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D016470:Bacteremia / Q000662:veterinary; D001473:Bartonella / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D001474:Bartonella Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D002415:Cats; D004197:Disease Reservoirs / Q000382:microbiology*; D004283:Dog Diseases / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male
chemical_list: D000907:Antibodies, Bacterial
keywords: Bartonella; Dogs; Experimental infection; Zoonosis