title: Rh(III)-catalyzed intermolecular C-H amination of 1-aryl-1H-pyrazol-5(4H)-ones with alkylamines.
abstract: An intermolecular C-H amination of 1-aryl-1H-pyrazol-5(4H)-ones was achieved under mild reaction conditions, using a low catalyst loading and with a broad scope of aminating reagents. This protocol not only provides the first example of rhodium(III)-catalyzed intermolecular aromatic C-H amination directed by an intrinsic functionality of the substrate/product but also features aminating an existing drug with either primary or secondary N-benzoate alkylamines as the coupling partners.
authors: Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China.
authors: Kui
authors: K
authors: Wu
authors: Zhoulong
authors: Z
authors: Fan
authors: Yu
authors: Y
authors: Xue
authors: Qizheng
authors: Q
authors: Yao
authors: Ao
authors: A
authors: Zhang
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D047069:Pyrazolones / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000588:Amines; D009942:Organometallic Compounds; D047069:Pyrazolones; D012238:Rhodium