title: [Can local administration of tranexamic acid reduce aspirin-induced bleeding in off-pump coronary artery bypass grafting( CABG) ?].
abstract: OBJECTIVE
  We examined the effect of local administration of tranexamic acid( TA) on reducing aspirin-induced bleeding in off-pump coronary artery bypass grafting(CABG).
  
  
  METHODS
  From July 2009 to January 2011, 88 cases with off-pump CABG were divided into 4 groups:group C including 19 cases without preoperative aspirin or local administration of TA, group A including 23 cases with preoperative aspirin alone, group T including 19 cases with local administration of TA alone, and group AT including 27 cases with both preoperative aspirin and local administration of TA.
  
  
  RESULTS
  The bleeding volume after 24 hours in group A was significantly larger than that in group C(p=0.0085). The bleeding volume in group AT was significantly smaller than that in group A (p<0.0001), and the bleeding volume in group T was also significantly smaller than that in group C (p=0.0054). There was no significant difference between group T and AT.
  
  
  CONCLUSIONS
  The use of local administration of tranexamic acid indicated the reduction of postoperative bleeding even in patients with preoperative aspirin use.
authors: Department of Cardiovascular Surgery, Toyohashi Heart Center, Toyohashi, Japan.
authors: Masakazu
authors: M
authors: Aoki
authors: Yoshihiro
authors: Y
authors: Goto
authors: Shinji
authors: S
authors: Ogawa
authors: Hiroshi
authors: H
authors: Baba
authors: Yasuhide
authors: Y
authors: Okawa
mesh_terms: D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D001241:Aspirin / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid; D001241:Aspirin