title: A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand.
abstract: An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effective strategy for identification of potential intracellular G-quadruplex targets for a ligand.
authors: Department of Chemistry, Kent State University, Kent, Ohio 44242, USA. sbasu@kent.edu.
authors: Gayan
authors: G
authors: Mirihana Arachchilage
authors: Mark J
authors: MJ
authors: Morris
authors: Soumitra
authors: S
authors: Basu
mesh_terms: D001483:Base Sequence; D002942:Circular Dichroism; D054856:G-Quadruplexes; D015723:Gene Library; D006801:Humans; D008024:Ligands; D012313:RNA / Q000737:chemistry*
chemical_list: D008024:Ligands; D012313:RNA