title: Comparison of the effect of reduced-fluence photodynamic therapy with intravitreal bevacizumab and standard-fluence alone for polypoidal choroidal vasculopathy.
abstract: BACKGROUND
  Photodynamic therapy (PDT) has previously been reported to be effective in treating polypoidal choroidal vasculopathy (PCV), with satisfactory polyp regression. However, the optimum treatment protocol remains controversial. This study compared the effect of reduced-fluence PDT combined with intravitreal bevacizumab (rPDT/IVB) and standard-fluence PDT (sPDT) alone for treating symptomatic PCV in Chinese patients.
  
  
  METHODS
  A retrospective review was carried out of the medical records of patients with PCV who were treated with rPDT/IVB (14 eyes of 13 patients) or sPDT (12 eyes of 12 patients) with at least 6 months of follow-up.
  
  
  RESULTS
  The mean best-corrected visual acuity of the rPDT/IVB group improved significantly at the 6-month follow-up (p = 0.041). Only one eye (7.1%) in the rPDT/IVB group showed a decrease in visual acuity, compared with four eyes (33.3%) in the sPDT group. A total of 40.0% of eyes in the sPDT group showed increased lipid exudate at follow-up 1 month after treatment, whereas no increase in lipid exudate was observed in the rPDT/IVB group (p = 0.015). The mean maximum area of post-treatment hemorrhage in the rPDT/IVB group was smaller than that in the sPDT group (2.57 ± 2.74 mm(2) vs. 12.69 ± 10.28 mm(2), p = 0.042).
  
  
  CONCLUSIONS
  Combination therapy with rPDT/IVB for patients with PCV showed encouraging results in vision improvement, a lower decrease in visual acuity, significantly less post-treatment lipid exudate and a smaller area of post-treatment hemorrhage at the 6-month follow-up than patients treated with sPDT.
authors: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Nai-Wen
authors: NW
authors: Fan
authors: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Ophthalmology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: leliew@vghtpe.gov.tw.
authors: Ling-Ing
authors: LI
authors: Lau
authors: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Ophthalmology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors: Shih-Jen
authors: SJ
authors: Chen
authors: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Ophthalmology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors: Chang-Sue
authors: CS
authors: Yang
authors: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Ophthalmology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors: Fenq-Lih
authors: FL
authors: Lee
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000068258:Bevacizumab; D002829:Choroid; D015862:Choroid Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D016491:Peripheral Vascular Diseases / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D011127:Polyps / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab
keywords: combination therapy; intravitreal bevacizumab; photodynamic therapy; polypoidal choroidal vasculopathy; reduced-fluence photodynamic therapy