title: [Association between CD24 polymorphism and genetic susceptibility to breast cancer: a case-control study].
abstract: OBJECTIVE
  To evaluate the association between CD24 polymorphism and genetic susceptibility to breast cancer in Chongqing women of Han nationality.
  
  
  METHODS
  In the case-control study, single nucleotide polymorphism of CD24 (rs3838646 and rs52812045) was genotyped by Sequenom MassArray®iPLEX GOLD System in 170 patients with breast cancer and 178 healthy controls. Data were analyzed via t test, Chi-square test, and logistic regression analysis.
  
  
  RESULTS
  The distribution of CD24 rs3838646 genotype and allelotype had no significant difference between the patients with breast cancer and healthy controls (χ2=3.54, P=0.17; χ2=2.29, P=0.13). Stratified by menstruation status, premenopausal individuals carrying CD24 rs3838646 Del allele significantly reduced the risk (OR=0.51, 95% CI 0.26-1.00, P=0.0485) of breast cancer compared with the individuals carrying CD24 CA/CA genotype. The distribution of CD24 rs52812045 genotypes and allelotypes had no significant difference between the patients with breast cancer and healthy controls (χ2=5.37, P=0.07; χ2=3.05, P=0.08). Compared with C/C homozygotes, CD24 rs52812045 T/T homozygotes had a significantly reduced risk (OR=0.47, 95% CI 0.23-0.95; P=0.04) for breast cancer.
  
  
  CONCLUSIONS
  CD24 polymorphism may be a marker for susceptibility to breast cancer in Han population in southwestern China. CD24 polymorphisms may be associated with a reduced risk of breast cancer in Chinese population. Further studies are needed to confirm these findings.
authors: Department of Breast Surgery, Chongqing Cancer Institute, Chongqing 400030, China.
authors: Xin
authors: X
authors: Zhou
authors: Yong
authors: Y
authors: Cao
authors: Jie
authors: J
authors: Luo
authors: Xiaohua
authors: X
authors: Zeng
mesh_terms: D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D051927:CD24 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human