title: Gradenigo's syndrome: is fusobacterium different? Two cases and review of the literature.
abstract: Gradenigo's syndrome is a rare but life threatening complication of acute otitis media (AOM), which includes a classic triad of otitis media, deep facial pain and ipsilateral abducens nerve paralysis. The incidence of Fusobacterium necrophorum infections has increased in recent years. We describe two cases of Gradenigo's syndrome caused by F. necrophorum. Additional four cases were identified in a review of the literature. Gradenigo's syndrome as well as other neurologic complications should be considered in cases of complicated acute otitis media. F. necrophorum should be empirically treated while awaiting culture results.
authors: Pediatrics Department, Shaare-Zedek Medical Center, Israel. Electronic address: meravheshin@gmail.com.
authors: Merav
authors: M
authors: Heshin-Bekenstein
authors: Pediatrics Department, Shaare-Zedek Medical Center, Israel; Faculty of Medicine, Hebrew University, Jerusalem, Israel; Pediatric Infectious Diseases Unit, Shaare-Zedek Medical Center, Israel.
authors: Orli
authors: O
authors: Megged
authors: Otolaryngology - Head and Neck Surgery Department, Shaare-Zedek Medical Center, Israel.
authors: Uri
authors: U
authors: Peleg
authors: Pediatrics Department, Shaare-Zedek Medical Center, Israel; Pediatric Intensive Care Unit, Shaare-Zedek Medical Center, Israel.
authors: Sarit
authors: S
authors: Shahroor-Karni
authors: Pediatrics Department, Shaare-Zedek Medical Center, Israel; Pediatric Intensive Care Unit, Shaare-Zedek Medical Center, Israel.
authors: Roman
authors: R
authors: Bass
authors: Pediatric Neurosurgery Unit, Hadassah-Hebrew University Medical Center, Israel.
authors: Moni
authors: M
authors: Benifla
authors: Pediatrics Department, Shaare-Zedek Medical Center, Israel; Faculty of Medicine, Hebrew University, Jerusalem, Israel; Pediatric Infectious Diseases Unit, Shaare-Zedek Medical Center, Israel.
authors: Maskit
authors: M
authors: Bar-Meir
mesh_terms: D002675:Child, Preschool; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000382:microbiology*; D005260:Female; D005674:Fusobacterium Infections / Q000175:diagnosis / Q000382:microbiology*; D005675:Fusobacterium necrophorum / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D059270:Petrositis / Q000175:diagnosis / Q000382:microbiology*
keywords: Acute otitis media; Fusobacterium necrophorum; Gradenigo's syndrome; Petrous apecitis