title: Systematic review and meta-analysis of published trials comparing the effectiveness of transanal endoscopic microsurgery and radical resection in the management of early rectal cancer.
abstract: OBJECTIVE
  A systematic analysis was conducted of trials comparing the effectiveness of transanal endoscopic microsurgery (TEMS) with radical resection (RR) for T1 and T2 rectal cancer.
  
  
  METHODS
  An electronic search was carried out of trials reporting the effectiveness of TEMS and RR in the treatment of T1 and T2 rectal cancers.
  
  
  RESULTS
  Ten trials including 942 patients were retrieved. There was a trend toward a higher risk of local recurrence (odds ratio 2.78; 95% confidence interval 1.42, 5.44; z = 2.97; P < 0.003) and overall recurrence (P < 0.01) following TEMS compared with RR. The risk of distant recurrence, overall survival (odds ratio 0.90; 95% confidence interval 0.49, 1.66; z = 0.33; P = 0.74) and mortality was similar. TEMS was associated with a shorter operation time and hospital stay and a reduced risk of postoperative complications (P < 0.0001). The included studies, however, were significantly diverse in stage and grade of rectal cancer and the use of neoadjuvant chemoradiotherapy.
  
  
  CONCLUSIONS
  Transanal endoscopic microsurgery appears to have clinically measurable advantages in patients with early rectal cancer. The studies included in this review do not allow firm conclusions as to whether TEMS is superior to RR in the management of early rectal cancer. Larger, better designed and executed prospective studies are needed to answer this question.
authors: Department of General and Laparoscopic Colorectal Surgery, Western Sussex Hospitals NHS Trust, Worthing Hospital, Worthing, UK.
authors: M S
authors: MS
authors: Sajid
authors: S
authors: S
authors: Farag
authors: P
authors: P
authors: Leung
authors: P
authors: P
authors: Sains
authors: W F A
authors: WF
authors: Miles
authors: M K
authors: MK
authors: Baig
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002277:Carcinoma / Q000473:pathology / Q000601:surgery / Q000628:therapy; D006801:Humans; D008866:Microsurgery / Q000379:methods*; D057605:Natural Orifice Endoscopic Surgery; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011351:Proctoscopy / Q000379:methods*; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D012007:Rectum / Q000601:surgery*; D016896:Treatment Outcome
keywords: abdominoperineal resection; anterior resection; lower rectal cancer; transanal endoscopic microsurgery