title: MSX1 gene variant - its presence in tooth absence - a case control genetic study.
abstract: BACKGROUND
  Non Syndromic tooth agenesis is a congenital anomaly with significant medical, psychological and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. The aim of this study was to test whether MSX1 671 T>C gene variant was involved in etiology of Non Syndromic tooth agenesis in Raichur Patients.
  
  
  METHODS
  Blood samples were collected with informed consent from 50 subjects having Non Syndromic tooth agenesis and 50 controls. Genomic DNA was extracted from the blood samples, Polymerase Chain Reaction was performed (PCR) and Restriction Fragment Length Polymorphism (RFLP) was performed for digestion products that were evaluated.
  
  
  RESULTS
  The RESULTS showed positive correlation between MSX1671 T>C gene variant and Non Syndromic tooth agenesis in Raichur Patients.
  
  
  CONCLUSIONS
  MSX1 671 T>C gene variant may be a good screening marker for Non Syndromic tooth agenesis in Raichur Patients . How to cite this article:Reddy NA, Adusumilli G, Devanna R, Pichai S, Rohra MG, Arjunan S. Msx1 Gene Variant - Its Presence in Tooth Absence - A Case Control Genetic Study. J Int Oral Health 2013; 5(5):20-6.
authors: Department of Orthodontics & Dento-facial Orthopaedics, AME's Dental College & Hospital, Raichur, Karnataka, India.
authors: Naveen Admala
authors: NA
authors: Reddy
authors: Gopinath
authors: G
authors: Adusumilli
authors: Raghu
authors: R
authors: Devanna
authors: Saravanan
authors: S
authors: Pichai
authors: Mayur Gobindram
authors: MG
authors: Rohra
authors: Sharmila
authors: S
authors: Arjunan
keywords: Case control; Msx1 mutation; tooth agenesis