title: Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.
abstract: Changes in the magnitude of the mitochondrial membrane potential occur in a range of important pathologies. To assess changes in membrane potential in patients, we set out to develop an improved mitochondria-targeted positron emission tomography probe comprising a lipophilic triphenylphosphonium cation attached to a fluorine-18 radionuclide via an 11-carbon alkyl chain, which is well-established to effectively transport to and localise within mitochondria. Here, we describe the radiosynthesis of this probe, 11-[(18) F]fluoroundecyl-triphenylphosphonium (MitoF), from no-carrier-added [(18) F]fluoride and a fully automated synthetic protocol to prepare it in good radiochemical yields (2-3 GBq at end-of-synthesis) and radiochemical purity (97-99%).
authors: Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
authors: L
authors: L
authors: Li
authors: L
authors: L
authors: Brichard
authors: L
authors: L
authors: Larsen
authors: D K
authors: DK
authors: Menon
authors: R A J
authors: RA
authors: Smith
authors: M P
authors: MP
authors: Murphy
authors: F I
authors: FI
authors: Aigbirhio
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling; D008928:Mitochondria / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: C000591007:11-fluoroundecyltriphenylphosphonium; D005462:Fluorine Radioisotopes; D009943:Organophosphorus Compounds; D019275:Radiopharmaceuticals
keywords: MitoF; PET; fluorine-18; imaging; mitochondria; triphenylphosphonium