title: Interaction of the neuropeptide S receptor gene Asn¹⁰⁷Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour.
abstract: Neuropeptide S is involved in anxiety and arousal modulation, and the functional polymorphism Asn107Ile (rs324981, A > T) of the neuropeptide S receptor gene (NPSR1) is associated with panic disorder and anxiety/fear-related traits. NPSR1 also interacts with the environment in shaping personality and impulsivity. We therefore examined whether the NPSR1 A/T polymorphism is associated with affective and anxiety disorders in a population-representative sample. Lifetime psychiatric disorders were assessed by MINI interview (n = 501) in the older cohort of the longitudinal Estonian Children Personality, Behaviour and Health Study (ECPBHS). Anxiety (STAI), self-esteem (RSES), depression (MÅDRS), suicide attempts and environmental factors were self-reported in both the younger (original n = 583) and the older cohort (original n = 593). Most of the NPSR1 effects were sex-specific and depended on environmental factors. Females with the functionally least active NPSR1 AA genotype and exposed to environmental adversity had affective/anxiety disorders more frequently; they also exhibited higher anxiety and depressiveness, and lower self-esteem. Female AA homozygotes also reported suicidal behaviour more frequently, and this was further accentuated by adverse family environment. In the general population, the NPSR1 A/T polymorphism together with environmental factors is associated with anxious, depressive and activity-related traits, increased prevalence of affective/anxiety disorders and a higher likelihood of suicidal behaviour.
authors: Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Estonia.
authors: Kariina
authors: K
authors: Laas
authors: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany.
authors: Andreas
authors: A
authors: Reif
authors: Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Estonia.
authors: Kirsti
authors: K
authors: Akkermann
authors: Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Estonia.
authors: Evelyn
authors: E
authors: Kiive
authors: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany.
authors: Katharina
authors: K
authors: Domschke
authors: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany.
authors: Klaus-Peter
authors: KP
authors: Lesch
authors: National Institute for Health Development, Estonian Centre of Behavioural and Health Sciences, Tallinn, Estonia.
authors: Toomas
authors: T
authors: Veidebaum
authors: Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Estonia.
authors: Jaanus
authors: J
authors: Harro
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001008:Anxiety Disorders / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D002648:Child; D004957:Estonia / Q000453:epidemiology; D005190:Family / Q000523:psychology; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012649:Self Concept; D012737:Sex Factors; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: C484532:NPSR1 protein, human; D043562:Receptors, G-Protein-Coupled