title: Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1.
abstract: OBJECTIVE
  To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1.
  
  
  METHODS
  Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria.
  
  
  RESULTS
  Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations.
  
  
  CONCLUSIONS
  Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
authors: José Lacerda
authors: JL
authors: Brasileiro
authors: Celso Maschaschi
authors: CM
authors: Inoye
authors: Ricardo Dutra
authors: RD
authors: Aydos
authors: Iandara Schettert
authors: IS
authors: Silva
authors: Gustavo Ribeiro
authors: GR
authors: Falcão
authors: Guido
authors: G
authors: Marks
authors: Daniel Martins
authors: DM
authors: Pereira
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*; D015203:Reproducibility of Results; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil; D010431:Pentoxifylline