title: Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis.
abstract: There has been significant interest in understanding how interactions between the host immune system and the gut microbiota regulate intestinal homeostasis. Recent data suggest that the Nod-like receptor (NLR) family of PRRs regulate both the composition of the gut microbiota and innate immune signaling pathways that prevent pathologic intestinal inflammation and tumorigenesis. In this review, we will focus on NLRP6 and NLRP12, two members of the NLR family that have emerged as important players in the maintenance of intestinal homeostasis, and discuss the signaling pathways engaged by these receptors as well as the current models of how these receptors protect against the development of colitis and tumorigenesis.
authors: Division of Hematology and Oncology, Department of Internal Medicine, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
authors: Grace Y
authors: GY
authors: Chen
mesh_terms: D003092:Colitis / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C476731:NLRP12 protein, human; C468563:NLRP6 protein, human
keywords: Cancer; Immune regulation; Immune responses; Inflammation; Innate immunity