title: An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent.
abstract: Invasive aspergillosis is a life-threatening infectious complication in immunocompromised patients, especially with malignancy, and in some cases, it causes extensive tissue destruction and subsequent systemic illness, leading to multiorgan failure and death. Skin involvement and amphotericin B resistance are very rare findings of aspergillosis. Herein, we report the case of a primary hemophagocytic syndrome patient who developed subcutaneous nodules in the 3(rd) month of bone marrow transplantation from which Aspergillus fumigatus was cultivated despite the fact that she was under antifungal therapy. In immunocompromised patients with prolonged fever, atypical presentations of invasive mycosis should be kept in mind, and early appropriate therapy should be initiated promptly to decrease morbidity and mortality.
authors: Hacettepe University Medical Faculty, Pediatric Infectious Disease Department, Ankara, Turkey. Electronic address: aslinur.o@gmail.com.
authors: Aslinur
authors: A
authors: Ozkaya-Parlakay
authors: Hacettepe University Medical Faculty, Pediatrics Department, Ankara, Turkey.
authors: Buse
authors: B
authors: Ozer-Bekmez
authors: Hacettepe University Medical Faculty, Pediatric Infectious Disease Department, Ankara, Turkey.
authors: Ates
authors: A
authors: Kara
authors: Hacettepe University Medical Faculty, Pediatric Hematology Department, Ankara, Turkey.
authors: Baris
authors: B
authors: Kuskonmaz
authors: Hacettepe University Medical Faculty, Pediatric Pathology Department, Ankara, Turkey.
authors: Zuhal
authors: Z
authors: Akcoren
authors: Hacettepe University Medical Faculty, Mycology Department, Ankara, Turkey.
authors: Sevtap
authors: S
authors: Arikan-Dagli
authors: Hacettepe University Medical Faculty, Radiology Department, Ankara, Turkey.
authors: Berna
authors: B
authors: Oguz
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D001232:Aspergillus fumigatus; D016026:Bone Marrow Transplantation; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B
keywords: Aspergillus fumigatus; child; primary hemophagocytic syndrome; skin