title: MicroRNA-128 governs neuronal excitability and motor behavior in mice.
abstract: The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.
authors: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA.
authors: Chan Lek
authors: CL
authors: Tan
authors: Joshua L
authors: JL
authors: Plotkin
authors: Morten T
authors: MT
authors: Venø
authors: Melanie
authors: M
authors: von Schimmelmann
authors: Philip
authors: P
authors: Feinberg
authors: Silas
authors: S
authors: Mann
authors: Annie
authors: A
authors: Handler
authors: Jørgen
authors: J
authors: Kjems
authors: D James
authors: DJ
authors: Surmeier
authors: Dónal
authors: D
authors: O'Carroll
authors: Paul
authors: P
authors: Greengard
authors: Anne
authors: A
authors: Schaefer
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000166:cytology; D003712:Dendrites / Q000502:physiology; D004827:Epilepsy / Q000378:metabolism; D006948:Hyperkinesis / Q000378:metabolism; D020935:MAP Kinase Signaling System; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000037:antagonists & inhibitors / Q000378:metabolism; D009043:Motor Activity; D009474:Neurons / Q000502:physiology*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000503:physiopathology; D016548:Prosencephalon / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D035683:MicroRNAs; C550324:Mirn128 microRNA, mouse; D012333:RNA, Messenger; D034743:RNA-Induced Silencing Complex; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3