title: Expression of MACC1 and c-Met in human gastric cancer and its clinical significance.
abstract: BACKGROUND
  Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters.
  
  
  METHODS
  Expressions of MACC1 and c-Met protein in a sample of 98 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features were analyzed.
  
  
  RESULTS
  The positive rates of MACC1 and c-Met protein in primary tumors were 61.22% and 59.18%, respectively. A significant correlation was found between expression of MACC1 and c-Met (P<0.05). Expression of the MACC1 protein in gastric cancer tissue was correlated with lymph node metastasis (χ2 = 10.555,P = 0.001), peritoneal metastasis (χ2 = 5.694, P = 0.017), and hepatic metastasis (χ2 = 4.540,P = 0.033), but not with age, gender, tumor size, location, clinical stage or the distant metastases (P>0.05).
  
  
  CONCLUSIONS
  The positive rate of MACC1 protein expression was related to the protein expression of c-Met. Both had a correlation with the presence of peritoneal metastasis, lymph node metastasis and hepatic metastasis, all of which contribute to a poor prognosis for gastric cancer patients.
authors: Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, 730000, PR, China.
authors: Tiankang
authors: T
authors: Guo
authors: Shandong Institute of Parasitic Diseases, Jining 272033, PR, China.
authors: Jingyu
authors: J
authors: Yang
authors: Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, 730000, PR, China.
authors: Jibin
authors: J
authors: Yao
authors: Department of Surgery, Ningxia Medical University, Yinchuan 750004, PR, China.
authors: Yongbin
authors: Y
authors: Zhang
authors: Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, 730000, PR, China.
authors: Mingxu
authors: M
authors: Da
authors: Department of Surgery, Ningxia Medical University, Yinchuan 750004, PR, China.
authors: Yaoxing
authors: Y
authors: Duan