title: Upregulation of human mammaglobin reduces migration and invasion of breast cancer cells.
abstract: Little is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.
authors: Departments of 1Physiology, 2Laboratory Medicine, and 3Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea.
authors: Eun-Ha
authors: EH
authors: Koh
authors: Young-Woo
authors: YW
authors: Cho
authors: Yun-Ja
authors: YJ
authors: Mun
authors: Ji Hyeon
authors: JH
authors: Ryu
authors: Eun-Jin
authors: EJ
authors: Kim
authors: Dae Seob
authors: DS
authors: Choi
authors: Kook-Young
authors: KY
authors: Maeng
authors: Jaehee
authors: J
authors: Han
authors: Dawon
authors: D
authors: Kang
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D060785:Mammaglobin A / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D014162:Transfection; D015854:Up-Regulation
chemical_list: D060785:Mammaglobin A; C556448:SCGB2A2 protein, human