title: Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.
abstract: Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for uncomplicated colonic diverticulosis. We conducted a prospective cross-sectional study in adults who underwent colonoscopy. Alcohol, alcohol related flushing, smoking, medications, and comorbidities were assessed by interview on the colonoscopy day. Alcohol consumption was categorized as nondrinker, light (1-180 g/week), moderate (181-360 g/week), and heavy (≥361 g/week). Smoking index was defined as the number of cigarettes per day multiplied by the number of smoking years and categorized as nonsmoker, <400, 400-799, and ≥800. A total of 2,164 consecutive patients were enrolled. Overall, 542 patients (25.1%) had uncomplicated colonic diverticulosis located on the right side (50%), bilaterally (29%), and on the left side (21%). Univariate analysis revealed age, male, smoking index, alcohol consumption, aspirin use, anticoagulants use, corticosteroid use, hypertension, and atherosclerotic disease as factors significantly associated with diverticulosis. Alcohol related flushing was not associated with the disease. Multivariate analysis showed increasing age (P<0.01), increasing alcohol consumption (P<0.01) and smoking (P<0.01), and atherosclerotic disease (P<0.01) as significantly associated factors. Alcohol and smoking were associated with right-sided and bilateral diverticula. In conclusion, one in four Japanese adults have colonic diverticulosis (50% right-sided). Age, alcohol consumption, and smoking were found to be significant risk factors for uncomplicated colonic diverticulosis, particularly right-sided and bilateral.
authors: Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
authors: Naoyoshi
authors: N
authors: Nagata
authors: Ryota
authors: R
authors: Niikura
authors: Takuro
authors: T
authors: Shimbo
authors: Yoshihiro
authors: Y
authors: Kishida
authors: Katsunori
authors: K
authors: Sekine
authors: Shohei
authors: S
authors: Tanaka
authors: Tomonori
authors: T
authors: Aoki
authors: Kazuhiro
authors: K
authors: Watanabe
authors: Junichi
authors: J
authors: Akiyama
authors: Mikio
authors: M
authors: Yanase
authors: Toshiyuki
authors: T
authors: Itoh
authors: Masashi
authors: M
authors: Mizokami
authors: Naomi
authors: N
authors: Uemura
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D003113:Colonoscopy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004241:Diverticulum, Colon / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*