title: Diagnostic utility of 123I-BMIPP imaging in patients with Takotsubo cardiomyopathy.
abstract: OBJECTIVE
  Takotsubo cardiomyopathy is a cardiac syndrome with an acute onset defined by chest symptoms and ST segment elevation on electrocardiograms. Takotsubo cardiomyopathy is sometimes misdiagnosed as acute myocardial infarction (AMI). Therefore a non-invasive diagnostic method is needed to be established for setting up appropriate strategies. The purpose of this study was to detect myocardial metabolic abnormalities and to determine the diagnostic usefulness of (123)I-beta-methy-iodophenyl pentadecanoic acid ((123)I-BMIPP) imaging in patients with takotsubo cardiomyopathy.
  
  
  RESULTS
  We examined 16 patients with takotsubo cardiomyopathy and 12 with AMI in the left anterior descending artery. All patients were studied with resting (123)I-BMIPP imaging. Total defect score (TDS) of (123)I-BMIPP and perfusion were semi-quantitatively determined with single-photon emission computed tomography (SPECT) imaging using a 17-segment 5-point model. TDS of (123)I-BMIPP were 4.8 ± 2.7 in patients with Takotsubo cardiomyopathy and 22.4 ± 10.7 in AMI. The ratio of summed BMIPP defect score of non-apical to apical segments in Takotsubo cardiomyopathy was smaller than that of the patients with AMI (0.1 ± 0.1 vs. 1.1 ± 0.7, p < 0.0001), indicating that (123)I-BMIPP abnormalities were exclusively observed the in apical area. The ratio of summed perfusion defect scores of non-apical to apical segments in takotsubo cardiomyopathy did not differ significantly from that of AMI (0.52 ± 0.6 vs. 0.57 ± 0.3, p = NS). Summed BMIPP defect score in the apical area of takotsubo cardiomyopathy was larger than that of perfusion defect score (3.9 ± 2.7 vs. 1.8 ± 1.8, p = 0.04).
  
  
  CONCLUSIONS
  Impaired metabolic metabolism exclusively in the apical region was observed by (123)I-BMIPP SPECT images in takotsubo cardiomyopathy. These typical metabolic SPECT features of the disease can be utilized on differential diagnosis of takotsubo cardiomyopathy.
authors: Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan. Electronic address: smatsuo@nmd.m.kanazawa-u.ac.jp.
authors: Shinro
authors: S
authors: Matsuo
authors: Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
authors: Kenichi
authors: K
authors: Nakajima
authors: Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
authors: Seigo
authors: S
authors: Kinuya
authors: Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors: Masakazu
authors: M
authors: Yamagishi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; C049338:iodofiltic acid
keywords: BMIPP; Diagnosis; Ischemia; Nuclear imaging; Takotsubo cardiomyopathy