title: Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.
abstract: OBJECTIVE
  Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).
  
  
  METHODS
  Biomarkers were measured in 67 KTR with AKI caused by different entities.
  
  
  RESULTS
  After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.
authors: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Vasco de Quiroga 15, Mexico City , Mexico and.
authors: Juan C
authors: JC
authors: Ramírez-Sandoval
authors: Jonatan
authors: J
authors: Barrera-Chimal
authors: Perla E
authors: PE
authors: Simancas
authors: Alejandro
authors: A
authors: Rojas-Montaño
authors: Ricardo
authors: R
authors: Correa-Rotter
authors: Norma A
authors: NA
authors: Bobadilla
authors: Luis E
authors: LE
authors: Morales-Buenrostro
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology / Q000652:urine*; D000209:Acute-Phase Proteins / Q000652:urine*; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000453:epidemiology / Q000652:urine*; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012372:ROC Curve; D012306:Risk; D017211:Treatment Failure
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine