title: Case series of probable sporadic Creutzfeldt-Jakob disease from Eastern India.
abstract: BACKGROUND
  Creutzfeldt-Jakob disease is a rapidly progressive, fatal, transmissible neurodegenerative disorder caused by prion protein. It is still considered rare in countries like India. This is probably due to nonavailability of autopsy studies in majority of the center. The recent European diagnostic criterion for sporadic CJD (sCJD) is useful for making an early diagnosis.
  
  
  OBJECTIVE
  To report a series of patients of probable sCJD from a neurology institute of eastern India.
  
  
  METHODS
  Patients of rapidly developing dementia fulfilling the diagnostic criteria for sCJD were included. All were investigated in detail to find out any possible treatable cause including electroencephalography (EEG), magnetic resonance imaging (MRI) of brain, and cerebrospinal fluid analysis.
  
  
  RESULTS
  A total 10 patients of probable sCJD diagnosed using the European diagnostic criterion between December 2011 and January 2013. The clinical features are consistent with other reported series. While 60% of patients had the classical EEG findings, 100% had typical MRI features. Eight patients died within a mean duration of 4.56 months from the disease onset.
  
  
  CONCLUSIONS
  The clinical features are similar to other reported series. Our observation raises question about the prevalence of this disease in India which needs more elaborate studies.
authors: Department of Neurology, Bangur Institute of Neurosciences, Kolkata, West Bengal, India.
authors: Atanu
authors: A
authors: Biswas
authors: Namrata
authors: N
authors: Khandelwal
authors: Alak
authors: A
authors: Pandit
authors: Arijit
authors: A
authors: Roy
authors: Deb Sankar
authors: DS
authors: Guin
authors: Goutam
authors: G
authors: Gangopadhyay
authors: Asit
authors: A
authors: Senapati
keywords: Creutzfeldt-Jakob disease; electroencephalography; magnetic resonance imaging