title: Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via both extrinsic and intrinsic pathways.
abstract: In this study, we investigated the potential for different components of the measles virus (MV) to induce apoptosis of HeLa cells and explored the apoptotic molecular mechanisms. After testing the 2 envelope glycoproteins hemagglutinin (H) and fusion (F), we found that MV H alone was sufficient to induce the apoptosis of HeLa cells, whereas MV F did not. MV F also had no influence on MV-H-mediated apoptosis. MV H could induce cellular apoptosis in HeLa cells through its interaction with the cellular receptor CD46 via both the TRAIL-mediated extrinsic pathway and the mitochondria-controlled intrinsic pathway, and that cross talk between these 2 pathways occurred during the process. These findings extend the functions of MV envelope glycoproteins in the pathogenesis of MV infection and suggest that MV H may be a potential therapeutic in the treatment of some cancers.
authors: a State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, People's Republic of China.
authors: Changhua
authors: C
authors: Yi
authors: Xin
authors: X
authors: Liu
authors: Yingle
authors: Y
authors: Liu
authors: Songya
authors: S
authors: Lu
authors: Yipeng
authors: Y
authors: Qi
mesh_terms: D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D017209:Apoptosis; D006367:HeLa Cells; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008457:Measles / Q000473:pathology / Q000821:virology*; D008459:Measles virus / Q000472:pathogenicity*; D051916:Membrane Cofactor Protein / Q000276:immunology / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D006389:Hemagglutinins, Viral; D051916:Membrane Cofactor Protein; D014759:Viral Envelope Proteins; C032397:hemagglutinin protein G, measles virus