title: Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields.
abstract: This article provides a comprehensive overview of oxygen ((17)O) magnetic resonance spectroscopy and imaging, including the advantages and challenges offered by the different methods developed thus far. The physiological role and relevance of oxygen, and its participation in aerobic metabolism, are addressed to emphasize the importance of the investigations and the efforts related to these developments. Furthermore, a number of methods employed in the determination of the cerebral metabolic rate of oxygen in neural cells will be presented, focusing primarily on methodologies enabling absolute quantification.
authors: Medical Imaging Physics, Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, 52425, Juelich, Germany.
authors: Ali
authors: A
authors: Gordji-Nejad
authors: Klaus
authors: K
authors: Möllenhoff
authors: Ana Maria
authors: AM
authors: Oros-Peusquens
authors: Deepu R
authors: DR
authors: Pillai
authors: Nadim Jon
authors: NJ
authors: Shah
mesh_terms: D001921:Brain / Q000378:metabolism*; D003952:Diagnostic Imaging; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008962:Models, Theoretical; D009474:Neurons / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010103:Oxygen Isotopes / Q000378:metabolism; D011522:Protons; D015203:Reproducibility of Results
chemical_list: D010103:Oxygen Isotopes; D011522:Protons; D010100:Oxygen