title: The value of neutrophil and lymphocyte count in frail older women.
abstract: Increasing evidence suggests that systemic inflammation is associated with many pathophysiological processes including frailty in older adults. We evaluated the relationships between white blood cell subtypes, geriatric assessment, and frailty syndrome and in particular, how they correlate with individual frailty criteria (involuntary loss of weight, low energy or exhaustion, slow mobility, muscle weakness, and low physical activity) in frail older women. There was a significant and positive correlation between the frailty score and neutrophil count, but a significantly negative correlation was found when this score was compared to the lymphocyte count. These associations were significant only for two frailty criteria: poor muscular strength and low physical activity. Further investigation into the role of white blood cell subtypes in ageing and its associated adverse outcomes in older adults is warranted, in particular in the loss of muscular strength and for poor physical activity.
authors: Department of Nursing, Faculty of Nursing, University of Valencia, Valencia, Spain.
authors: Julio
authors: J
authors: Fernández-Garrido
authors: Department of Nursing, Faculty of Nursing, University of Valencia, Valencia, Spain.
authors: Rut
authors: R
authors: Navarro-Martínez
authors: Department of Nursing, Faculty of Nursing, University of Valencia, Valencia, Spain.
authors: Cristina
authors: C
authors: Buigues-González
authors: GeroResidencias La Saleta, Valencia, Spain.
authors: Mary
authors: M
authors: Martínez-Martínez
authors: Department of Nursing, Faculty of Nursing, University of Valencia, Valencia, Spain; Cardiology Department, Hospital Clínico Universitario, Valencia, Spain.
authors: Vicente
authors: V
authors: Ruiz-Ros
authors: Department of Nursing, Faculty of Nursing, University of Valencia, Valencia, Spain. Electronic address: Omar.Cauli@uv.es.
authors: Omar
authors: O
authors: Cauli
mesh_terms: D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment / Q000379:methods; D018737:Hand Strength; D006801:Humans; D007154:Immune System Diseases / Q000097:blood; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000502:physiology*; D053580:Muscle Strength / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology; D010865:Pilot Projects; D015431:Weight Loss / Q000502:physiology
keywords: Ageing; Frailty; Lymphocyte; Muscular strength; Neutrophil; Physical activity