title: Antinociceptive actions of peripheral glucose administration.
abstract: The effects of intraperitoneal (ip) D-glucose administration on antinociception were studied in male Long-Evans rats. Rats were assessed for antinociception using the hot-water tail-withdrawal procedure (54±0.2 °C) to determine if peripheral administration of D-glucose (300, 560, or 720 mg/kg) would enhance morphine-mediated antinociception (MMA) (1.0, 3.0, 4.2, 5.6, and 10.0mg/kg cumulative-dosing regime) and if D-glucose (560, 720, or 1000 mg/kg) alone could produce antinociceptive activity that was naloxone (0.32 mg/kg) reversible. Additionally, the actions of D-glucose on MMA were compared with a stereoisomer, L-glucose, which is not metabolized. The results of these studies demonstrate that peripheral administration of D-glucose significantly enhances MMA and that D-glucose alone produces antinociceptive actions that are potentially mediated by the endogenous opioid system. Furthermore, L-glucose failed to have an effect on MMA suggesting that the alterations in antinociception seen with D-glucose are not due to stressors such as osmolality or injection. The current studies provide evidence that D-glucose alteration of antinociception is not simply a response to taste or gustation.
authors: Department of Psychology, Tufts University, Medford, MA 02155,USA. Electronic address: yamamoto@mclean.harvard.edu.
authors: Rinah T
authors: RT
authors: Yamamoto
authors: Department of Psychology, Tufts University, Medford, MA 02155,USA.
authors: Wendy
authors: W
authors: Foulds-Mathes
authors: Department of Psychology, Tufts University, Medford, MA 02155,USA.
authors: Robin B
authors: RB
authors: Kanarek
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D000700:Analgesics; D005947:Glucose
keywords: Antinociception; EOS; Glucose; MMA; Morphine; Rats; endogenous opioid system; morphine mediated antinociception