title: Synthesis, spectroscopic, X-ray crystal structure, biological and DNA interaction studies of organotin(IV) complexes of 2-(4-ethoxybenzylidene) butanoic acid.
abstract: Six organotin(IV) carboxylates of the type R2SnL2 [R=CH3 (1), n-C4H9 (2), n-C8H17 (3)] and R3SnL [R=CH3 (4), n-C4H9 (5), C6H5 (6), where L=2-(4-ethoxybenzylidene) butanoic acid, have been synthesized and characterized by elemental analysis, FT-IR and NMR ((1)H, (13)C). The complex (1) was also analyzed by single crystal X-ray analysis. The complexes were screened for antimicrobial, cytotoxic and anti-tumor activities. The results showed significant activity in each area of the activity with few exceptions. DNA interactions studies of ligand HL and representative complex 2 were investigated by UV-Visible absorption spectroscopy and viscosity measurements. The results showed that both ligand HL and complex 2 interact with SS-DNA via intercalation as well as minor groove binding.
authors: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: mtnazir@yahoo.com.
authors: Muhammad
authors: M
authors: Tariq
authors: Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.
authors: Niaz
authors: N
authors: Muhammad
authors: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: drsa54@yahoo.com.
authors: Saqib
authors: S
authors: Ali
authors: Department of Microbiology, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors: Jafir Hussain
authors: JH
authors: Shirazi
authors: Department of Physics, University of Sargodha, Sargodha, Pakistan.
authors: Muhammad Nawaz
authors: MN
authors: Tahir
authors: Chemistry Division, Pakistan Institute of Nuclear Science and Technology, Nilore, Islamabad, Pakistan.
authors: Nasir
authors: N
authors: Khalid
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D020148:Butyric Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D005399:Fishes; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008826:Microbial Sensitivity Tests; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D010941:Plant Tumors; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity / Q000187:drug effects
chemical_list: C000593950:2-(4-ethoxybenzylidene)butanoic acid; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001597:Benzylidene Compounds; D002087:Butyrates; D008024:Ligands; D009947:Organotin Compounds; D020148:Butyric Acid; D004247:DNA
keywords: Antimicrobial activity; Antitumor activity; Cytotoxic activity; Distannoxane