title: One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.
abstract: The versatile (18) F-labeled prosthetic group, 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP), was synthesized in a single step in 45 min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [(18) F]NFP, [(18) F]GalactoRGD - the current 'gold standard' tracer for imaging the expression of αV β3 integrin - was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [(18) F]fluoride.
authors: School of Chemistry, The University of Melbourne, Vic., 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Vic., 3010, Australia; The Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
authors: Mohammad B
authors: MB
authors: Haskali
authors: Peter D
authors: PD
authors: Roselt
authors: John A
authors: JA
authors: Karas
authors: Wayne
authors: W
authors: Noonan
authors: Christian W
authors: CW
authors: Wichmann
authors: Andrew
authors: A
authors: Katsifis
authors: Rodney J
authors: RJ
authors: Hicks
authors: Craig A
authors: CA
authors: Hutton
mesh_terms: D001386:Azides / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D010455:Peptides / Q000138:chemical synthesis; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D001386:Azides; D005462:Fluorine Radioisotopes; D010455:Peptides; D019275:Radiopharmaceuticals; C102277:4-nitrophenyl 2-fluoropropionate
keywords: PET imaging; RGD peptide; [18F]fluoride; fluoropropionate; radiofluorination