title: Enhanced osseointegration and antibacterial action of zinc-loaded titania-nanotube-coated titanium substrates: in vitro and in vivo studies.
abstract: Poor osseointegration and infection resulting from implants are serious medical issues, and it is not straightforward to manufacture implants that can simultaneously address both of these problems. In this study, we produced coatings containing titania nanotubes (TiO2 -NTs) incorporated with zinc (NT-Zn) on Ti substrates by anodization and hydrothermal treatment. The zinc content was controlled by varying the duration of the hydrothermal treatment. The NT-Zn implants not only exhibited improved bone formation (shown by both in vitro and in vivo studies), which enhances osseointegration between bone and implant, but also inhibited growth of bacteria. The cytotoxicity of locally high concentrations of zinc in the NT-Zn3h specimens observed during in vitro studies was mitigated by the effects of dilution in vivo.
authors: Department of Orthopedics Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Yong
authors: Y
authors: Li
authors: Wei
authors: W
authors: Xiong
authors: Chengcheng
authors: C
authors: Zhang
authors: Biao
authors: B
authors: Gao
authors: Hanfeng
authors: H
authors: Guan
authors: Hao
authors: H
authors: Cheng
authors: Jijiang
authors: J
authors: Fu
authors: Feng
authors: F
authors: Li
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005260:Female; D008422:Materials Testing / Q000379:methods; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D016348:Osseointegration; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D014025:Titanium; D015032:Zinc
keywords: antibacterial activity; osteogenic ability; preosteoblast; titania nanotubes; zinc