title: Aripiprazole: a new risk factor for pathological gambling? A report of 8 case reports.
abstract: OBJECTIVE
  It is commonly accepted that pathological gambling results from the interaction of multiple risk factors. Among these, dopamine replacement therapy (DRT) prescribed for Parkinson disease can be cited. Another dopamine agonist, aripiprazole, could be a new risk factor. We decided to explore this potential adverse drug reaction (ADR).
  
  
  METHODS
  Based on a cohort of 166 pathological gamblers starting treatment in our department, data of each of the 8 patients treated by aripiprazole at inclusion were analyzed.
  
  
  RESULTS
  The patients involved were schizophrenic or bipolar, mostly young men with a history of addictive disorders and regular gambling prior to the prescription of aripiprazole. For each one of them, the causality of aripiprazole was considered, using an algorithm. The probability that pathological gambling is actually due to aripiprazole is "possible" in 7 cases out of 8, and "doubtful" in one.
  
  
  CONCLUSIONS
  Adverse drug reactions were confronted with other already published case reports. Dopamine partial agonist mechanism of aripiprazole could explain the occurrence of pathological gambling.
authors: Pharmacology Department, Nantes University Hospital, 9, quai Moncousu., 44093 Nantes cedex 1, France.
authors: L
authors: L
authors: Gaboriau
authors: Pharmacology Department, Nantes University Hospital, 9, quai Moncousu., 44093 Nantes cedex 1, France; EA 4275 "Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences", Nantes University, 1, rue Gaston Veil, BP 53508, 44035 Nantes cedex 1, France.
authors: C
authors: C
authors: Victorri-Vigneau
authors: Pharmacology Department, Nantes University Hospital, 9, quai Moncousu., 44093 Nantes cedex 1, France; EA 4275 "Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences", Nantes University, 1, rue Gaston Veil, BP 53508, 44035 Nantes cedex 1, France.
authors: M
authors: M
authors: Gérardin
authors: Pharmacology Department, Nantes University Hospital, 9, quai Moncousu., 44093 Nantes cedex 1, France.
authors: G
authors: G
authors: Allain-Veyrac
authors: Pharmacology Department, Nantes University Hospital, 9, quai Moncousu., 44093 Nantes cedex 1, France; EA 4275 "Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences", Nantes University, 1, rue Gaston Veil, BP 53508, 44035 Nantes cedex 1, France.
authors: P
authors: P
authors: Jolliet-Evin
authors: EA 4275 "Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences", Nantes University, 1, rue Gaston Veil, BP 53508, 44035 Nantes cedex 1, France; Addictology and Psychiatry Department, Nantes University Hospital, 85, rue Saint Jacques, 44093 Nantes cedex 1, France. Electronic address: marie.bronnec@chu-nantes.fr.
authors: M
authors: M
authors: Grall-Bronnec
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D005715:Gambling / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole
keywords: Adverse drug reaction; Aripiprazole; Causality; Dopamine partial agonist; Pathological gambling