title: Copper-boxmi complexes as highly enantioselective catalysts for electrophilic trifluoromethylthiolations.
abstract: The enantioselective trifluoromethylthiolation of β-ketoesters using chiral copper-boxmi complexes as catalysts is reported. A number of α-SCF3-substituted β-ketoesters have been obtained with up to >99% enantiomeric excess (ee), and the trifluoromethylthiolated products were then transformed diastereoselectively to α-SCF3-β-hydroxyesters with two adjacent quaternary stereocenters.
authors: Catalysis Research Laboratory (CaRLa), Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors: Qing-Hai
authors: QH
authors: Deng
authors: Christoph
authors: C
authors: Rettenmeier
authors: Hubert
authors: H
authors: Wadepohl
authors: Lutz H
authors: LH
authors: Gade
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004952:Esters; D007462:Iodobenzenes; D007463:Iodobenzoates / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D004952:Esters; D007462:Iodobenzenes; D007463:Iodobenzoates; D007659:Ketones; C476101:o-iodoxybenzoic acid; D003300:Copper
keywords: asymmetric catalysis; copper; pincer ligands; trifluoromethylthiolation; β-ketoesters