title: [Effects of an insertion/deletion polymorphism of angiotensin converting enzyme gene on the changes of serum lipid ratios and blood pressure induced by a high-carbohydrate and low-fat diet].
abstract: OBJECTIVE
  To investigate the effects of an insertion/deletion (I/D) polymorphism at the intron 16 of the gene of angiotensin converting enzyme (ACE) on the changes of serum lipid ratios and blood pressure induced by a high-carbohydrate and low-fat (HC/LF) diet in healthy Chinese Han youth.
  
  
  METHODS
  Fifty six healthy Chinese Han young volunteers were enrolled. A washout diet was given for seven days followed by the HC/LF diet for six days. Serum lipids and blood pressure were measured on the 1st, 8th, and 14th days. Serum lipid ratios were calculated. The ACE I/D polymorphism was detected by PCR.
  
  
  RESULTS
  There were no significant differences of serum lipid ratios and blood pressure at baseline and before and after the HC/LF diet between the II genotype and the D carriers (ID and DD genotypes) in the whole study population, the males or the females separately. When compared with those before the HC/LF diet, all the subjects regardless of the genotype experienced statistical decreases of low density lipoprotein-cholesterol/high density lipoprotein-cholesterol (LDL-C/HDL-C) and total cholesterol (TC)/HDL-C, but significant decrease of systolic blood pressure (SBP) was only found in the subjects with the II genotype. After taking into account gender, triglyceride (TG)/HDL-C and Log (TG/HDL-C) decreased in the males with theII genotype and increased in the female counterparts. The decreases of TC/HDL-C and LDL-C/HDIL-C were observed in all the males and the female D carriers. SBP decreased only in the male D carriers.
  
  
  CONCLUSIONS
  The interaction of the HC/LF diet with the I allele of the intron 16 I/D polymorphism at the ACE gene decreases TG/HDL-C and log (TG/HDL-C) in males, but increases TG/HDL-C and log (TG/HDL-C) in females in the Chinese young population. The interplay with the D allele lowers SBP in males, and TC/HDL-C and LDL-C/ HDL-C in females.
authors: Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.
authors: Rong-Rong
authors: RR
authors: Zhang
authors: Yong-Yan
authors: YY
authors: Song
authors: Mei
authors: M
authors: Fan
authors: Yuan-Hao
authors: YH
authors: Li
authors: Zhe
authors: Z
authors: Jiang
authors: Zhen
authors: Z
authors: Zhang
authors: Ding-Zhi
authors: DZ
authors: Fang
mesh_terms: D001794:Blood Pressure; D018752:Diet, Fat-Restricted; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D007438:Introns; D008055:Lipids / Q000097:blood*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008055:Lipids; D007703:Peptidyl-Dipeptidase A