title: Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells.
abstract: The activity of gypenosides and gynogenin of Gynostemma pentaphyllum against non-small cell lung carcinoma (NSCLC) A549 cells was investigated to identify the structural characteristics of gypenosides and gynogenin to have anti-NSCLC activity. Of the tested dammarane-type compounds, 20S-dammar-24-en-2α,3β,12β,20-tetrol showed the strongest activity against A549 cells. Based on the structure and cytotoxic activity relationships of gypenosides and gynogenin, the OH group in C-2, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.
authors: Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China.
authors: Dao-Jin
authors: DJ
authors: Chen
authors: Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China.
authors: Hui-Min
authors: HM
authors: Liu
authors: Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China.
authors: Shao-Fang
authors: SF
authors: Xing
authors: Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China. Electronic address: xlpiao@163.com.
authors: Xiang-Lan
authors: XL
authors: Piao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D029774:Gynostemma / Q000737:chemistry*; D006801:Humans; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes; C588349:gynogenin; C474918:gypenoside
keywords: A549 cell; Gynogenin; Gypenoside; Non-small cell lung carcinoma (NSCLC); Saponins conversion