title: Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients.
abstract: Tumor recurrence and metastasis are pressing issues of patients with colorectal cancer who receive surgery. Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor. We aimed to investigate the clinical significance and prognostic value of matrilysin-2 in human colorectal cancer. Colorectal cancer and adjacent normal samples from 201 patients were collected. Matrilysin-2 expression level was investigated by immunohistochemistry assay, and its association with overall survival of patients was analyzed by statistical analysis. Results showed that matrilysin-2 expression level significantly elevated in colorectal cancer compared with adjacent normal specimens. Matrilysin-2 expression was also found to be associated with cancer invasion, lymph node metastasis, distant metastasis, and TNM stage. In addition, survival analysis showed that elevated matrilysin-2 expression was associated with poor overall survival of patients. Cox's proportional hazards model indicated that matrilysin-2 was an independent prognostic marker for patients with colorectal cancer. The present study found that the expression of matrilysin-2 increased in colorectal cancer and was associated with tumor progression. It also provided the first evidence that matrilysin-2 expression was an independent prognostic factor for patients with colorectal cancer, which might be a high specific biomarker for colorectal cancer.
authors: Department of General Surgery, the First Affiliated Hospital of Chengdu Medical College, Baoguang Road 278#, Chengdu, 610500, Sichuan, China, lyhqlin@163.com.
authors: Qinglin
authors: Q
authors: Hu
authors: Chuanjing
authors: C
authors: Yan
authors: Chengfei
authors: C
authors: Xu
authors: Hai
authors: H
authors: Yan
authors: Lian
authors: L
authors: Qing
authors: Yanjun
authors: Y
authors: Pu
authors: Zeyou
authors: Z
authors: He
authors: Xiaojun
authors: X
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020782:Matrix Metalloproteinases / Q000502:physiology; D053505:Matrix Metalloproteinases, Secreted / Q000032:analysis / Q000502:physiology*; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: C410599:MMP26 protein, human; D020782:Matrix Metalloproteinases; D053505:Matrix Metalloproteinases, Secreted