title: The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
abstract: BACKGROUND
  To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL), and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma.
  
  
  METHODS
  Patients with glaucomatous optic nerve damage were enrolled in this cross-sectional study. Peripapillary RNFL thickness was obtained with spectral-domain optical coherence tomography (SD-OCT). Function was assessed by patient-reported visual functioning using the Rasch-calibrated Glaucoma Activity Limitation 9 (GAL-9) questionnaire and standard automated perimetry. The impact of peripapillary RNFL loss on functional impairment was analyzed with correlation and linear regression analyses.
  
  
  RESULTS
  A total of 176 eyes from 88 glaucoma patients were included. The SD-OCT assessed temporal-superior and temporal-inferior RNFL sector of the worse eye revealed significant correlation with the GAL-9 scores (r=-0.298, p=0.011 and r=-0.251, p=0.033, respectively). In mutivariate regression analysis, the best predictors for patient-reported visual functioning were visual acuity of the better eye and mean defect of the worse eye (R(2)=0.334), while structural parameters could not enhance the prediction of GAL-9 scores.
  
  
  CONCLUSIONS
  Self-reported visual functioning of patients with glaucoma is better predicted by visual performance data than structural parameters. However, some structural changes of the worse eye are significantly correlated with patient-reported visual functioning.
authors: Ludwig-Maximilians University, Department of Ophthalmology, Klinikum der Universität Muenchen, Campus Innenstadt, Munich, Germany.
authors: Christoph
authors: C
authors: Hirneiß
authors: Lukas
authors: L
authors: Reznicek
authors: Michaela
authors: M
authors: Vogel
authors: Konrad
authors: K
authors: Pesudovs
mesh_terms: D000368:Aged; D005260:Female; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057566:Self Report; D041623:Tomography, Optical Coherence; D014785:Vision, Ocular