title: Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice.
abstract: Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 μg/kg i.p.) was administered once per day for 7 days (day 0-6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0-6) or late phase (day 7-13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain.
authors: Department of Pharmacology, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
authors: Dun
authors: D
authors: Linglu
authors: Li
authors: L
authors: Yuxiang
authors: Xu
authors: X
authors: Yaqiong
authors: Zhou
authors: Z
authors: Ru
authors: Ma
authors: M
authors: Lin
authors: Jin
authors: J
authors: Shaoju
authors: Du
authors: D
authors: Juan
authors: Sun
authors: S
authors: Tao
authors: Yu
authors: Y
authors: Jianqiang
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000188:drug therapy; D051379:Mice; D008813:Mice, Inbred ICR; D009437:Neuralgia / Q000139:chemically induced / Q000188:drug therapy*; D017288:Pain Threshold / Q000187:drug effects; D011807:Quinolizines / Q000627:therapeutic use*; D014750:Vincristine / Q000633:toxicity*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000700:Analgesics; D000972:Antineoplastic Agents, Phytogenic; D011807:Quinolizines; D014750:Vincristine; D000093842:Matrines