title: Effects of activation of maternal immune system at early stages of pregnancy on antitumor immunity of the progeny.
abstract: The effects of maternal immune system on the formation and functioning of the fetus is an important problem. Single stimulation of immune system of female C57Bl/6 mice with concanavalin A at the early stages of pregnancy before the formation of fetal immune organs was followed by impairment of antitumor immunity in the progeny by the time of puberty. These changes manifested in the increased survival rate of B16 melanoma, high rate of death of tumor-bearing animals, and low cytotoxic activity of spleen cells on L-929 fibrosarcoma cells.
authors: Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. ober@mail.ru.
authors: S S
authors: SS
authors: Obernikhin
mesh_terms: D000818:Animals; D060467:Disease Resistance / Q000276:immunology; D005260:Female; D007113:Immunity, Innate; D008297:Male; D008546:Melanoma, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D047368:Tumor Burden