title: Relation of plasma adiponectin levels and aortic stiffness after acute ST-segment elevation myocardial infarction.
abstract: BACKGROUND
  Pulse wave velocity is a measure of aortic stiffness and an independent predictor of cardiovascular morbidity and mortality. Adiponectin is involved in atherosclerosis and inflammation. In the present study we aimed to explore the association between plasma adiponectin concentrations and pulse wave velocity in the acute phase after ST-segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  Forty-six consecutive STEMI patients (mean age 57 ± 11 years) treated with primary percutaneous coronary intervention (PCI) were enrolled in this cross-sectional study. Plasma adiponectin was measured 2 days after index event by enzyme-linked immunosorbent assay. Aortic pulse wave velocity (PWV) was calculated by the transit-time method with the use of a velocity-encoded, phase-contrast cardiac magnetic resonance protocol.
  
  
  RESULTS
  Median plasma adiponectin concentration was 2385 ng/ml (interquartile range 1735-5403). Males had lower plasma adiponectin values than females and current smokers had lower values than non-smokers (all p<0.02). Adiponectin was significantly associated with PWV (r=0.505, p<0.001), age (r=0.437, p=0.002), and total cholesterol (r=0.468, p=0.001). Multiple linear regression analysis revealed adiponectin as a predictor of PWV independently of age, sex, smoking status, total cholesterol, and N-terminal pro-B-type natriuretic peptide (p=0.027).
  
  
  CONCLUSIONS
  Plasma adiponectin concentrations are strongly associated with aortic stiffness in patients after acute STEMI treated with primary PCI. Our data support a possible role for adiponectin as an independent risk marker for increased aortic stiffness in STEMI patients.
authors: Innsbruck Medical University, Innsbruck, Austria.
authors: S J
authors: SJ
authors: Reinstadler
authors: G
authors: G
authors: Klug
authors: H J
authors: HJ
authors: Feistritzer
authors: A
authors: A
authors: Mayr
authors: K
authors: K
authors: Bader
authors: J
authors: J
authors: Mair
authors: R
authors: R
authors: Esterhammer
authors: M
authors: M
authors: Schocke
authors: B
authors: B
authors: Metzler
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001013:Aorta, Thoracic / Q000473:pathology / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; ST-segment elevation myocardial infarction; aortic stiffness; cardiac magnetic resonance; pulse wave velocity