title: Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect.
abstract: Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs).
authors: College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
authors: Tran Manh
authors: TM
authors: Hung
authors: College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
authors: To Dao
authors: TD
authors: Cuong
authors: College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Jeong Ah
authors: JA
authors: Kim
authors: College of Natural Science, Kangwon National University, Kangwon 200-701, Republic of Korea.
authors: Nara
authors: N
authors: Tae
authors: College of Natural Science, Kangwon National University, Kangwon 200-701, Republic of Korea.
authors: Jeong Hyung
authors: JH
authors: Lee
authors: College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: bsmin@cu.ac.kr.
authors: Byung Sun
authors: BS
authors: Min
mesh_terms: D045784:Abietanes; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D045784:Abietanes; D000470:Alkaloids; D020533:Angiogenesis Inhibitors; D004224:Diterpenes; C010696:cassaine
keywords: Anti-angiogenesis; Cassaine diterpenoid amide; Erythrophleum fordii; Leguminosae