title: FGFR1 signaling is associated with the magnitude of morphological integration in human head shape.
abstract: OBJECTIVE
  The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compelling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signaling process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head.
  
  
  METHODS
  We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three-dimensional head landmark coordinates taken on 176 individuals.
  
  
  RESULTS
  Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed.
  
  
  CONCLUSIONS
  Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head.
authors: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul. Caixa Postal 15053, 91501-970, Porto Alegre, RS, Brazil.
authors: Tábita
authors: T
authors: Hünemeier
authors: Jorge
authors: J
authors: Gómez-Valdés
authors: Soledad
authors: S
authors: De Azevedo
authors: Mirsha
authors: M
authors: Quinto-Sánchez
authors: Luciane
authors: L
authors: Passaglia
authors: Francisco M
authors: FM
authors: Salzano
authors: Gabriela
authors: G
authors: Sánchez-Mejorada
authors: Víctor Acuña
authors: VA
authors: Alonzo
authors: Neus
authors: N
authors: Martínez-Abadías
authors: Maria-Cátira
authors: MC
authors: Bortolini
authors: Rolando
authors: R
authors: González-José
mesh_terms: D000328:Adult; D044383:Black People / Q000235:genetics; D002508:Cephalometry; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008800:Mexico; D020641:Polymorphism, Single Nucleotide; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction; D012886:Skull / Q000033:anatomy & histology*; D044465:White People / Q000235:genetics
chemical_list: D051496:Receptor, Fibroblast Growth Factor, Type 1