title: The incidence of breast tumor during experimental hyperthyroidism.
abstract: The incidence of breast tumor in inbred C3H-A mice (virgin female) from hyperthyroid, hypothyroid, and euthyroid control groups at week 44 of the experiment was 86.67, 30, and 62.5%, respectively. The percentage of metastatic lymph nodes in these groups was 65.9±16.7, 35.9±5.9, and 53.9±7.2%, respectively (p<0.005). It was shown that hyperthyroidism was associated with increased incidence and aggressiveness of breast tumor, while hypothyroidism was associated with lower incidence of breast tumor in comparison with the control.
authors: St. Petersburg State Pediatric Medical Academy, Ministry of Health of the Russian Federation; I. I. Mechnikov North-Western State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia. glushakovruslan@gmail.com.
authors: R I
authors: RI
authors: Glushakov
authors: S N
authors: SN
authors: Proshin
authors: N I
authors: NI
authors: Tapil'skaya
mesh_terms: D000818:Animals; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000453:epidemiology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000453:epidemiology*; D008207:Lymphatic Metastasis; D015674:Mammary Neoplasms, Animal / Q000453:epidemiology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D015996:Survival Rate; D013961:Thyroid Gland / Q000473:pathology; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D013974:Thyroxine