title: The Glasgow Prognostic Score accurately predicts survival in patients with biliary tract cancer not indicated for surgical resection.
abstract: The Glasgow Prognostic Score (GPS) and neutrophil to lymphocyte ratio (NLR) are associated with the survival in patients with various types of malignancy. The aim of this study was to investigate the prognostic value of the GPS and NLR in patients with biliary tract cancer (BTC) undergoing palliative chemotherapy or best supportive care (BSC). Fifty-two patients with newly diagnosed BTC were retrospectively evaluated. We investigated the correlation between the GPS, NLR, and the overall survival rates. The area under the receiver operating characteristics curve (AUC) was calculated to compare the predictive ability of each score. Both the univariate and multivariate analyses were performed to identify clinicopathological variables associated with the overall survival. There were significant differences between the GPS groups regarding the neutrophil levels (p < 0.0001), Hb (p = 0.024), Alb (p < 0.0001) and CRP (p < 0.0001). A significant difference in the overall survival was found between the groups stratified based on the GPS, NLR (p < 0.001). The GPS had a higher AUC value (0.905) in comparison to the NLR (0.648). In the multivariate analysis, the sex (p = 0.002), CA19-9 (p < 0.0001) and the GPS (p < 0.0001) were found to be independently associated with the overall survival. Our results demonstrate that the GPS is an independent marker of the prognosis in patients with BTC undergoing palliative chemotherapy or BSC, and is superior to the NLR in terms of its prognostic ability.
authors: Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital, 4-11-1 Izumihon-cho, Komae-shi, Tokyo, 201-8601, Japan.
authors: Akira
authors: A
authors: Iwaku
authors: Akiyoshi
authors: A
authors: Kinoshita
authors: Hiroshi
authors: H
authors: Onoda
authors: Nao
authors: N
authors: Fushiya
authors: Hirokazu
authors: H
authors: Nishino
authors: Masato
authors: M
authors: Matsushima
authors: Hisao
authors: H
authors: Tajiri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001661:Biliary Tract Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D002452:Cell Count; D005260:Female; D006801:Humans; D007249:Inflammation; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000166:cytology; D010166:Palliative Care / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome