title: In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles.
abstract: Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross-linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength.
authors: Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors: Sébastien
authors: S
authors: Cajot
authors: Daureen
authors: D
authors: Schol
authors: Fabienne
authors: F
authors: Danhier
authors: Véronique
authors: V
authors: Préat
authors: Marie-Claire
authors: MC
authors: Gillet De Pauw
authors: Christine
authors: C
authors: Jérôme
mesh_terms: D000818:Animals; D001692:Biological Transport; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D004339:Drug Compounding; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008823:Micelles; D010078:Oxazines / Q000737:chemistry; D010084:Oxidation-Reduction; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D003432:Cross-Linking Reagents; D004220:Disulfides; D004337:Drug Carriers; D005456:Fluorescent Dyes; D008823:Micelles; D010078:Oxazines; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols; C044808:nile red
keywords: cross-linked micelles; cytotoxicity; disulfide bridges; internalization; smart drug delivery