title: Study on anti-Ehrlich ascites tumour effect of Pinellia ternata polysaccharide in vivo.
abstract: The objectives of the study were to investigate the anti-tumour activity of Pinellia ternata polysaccharide in vivo, and to preliminarily explore the possible mechanism of its antitumour action. Mouse model of Ehrlich ascites tumour (solid tumour) was used to detect the serum SOD, MDA and GSH-Px levels in mouse and to measure the tumour inhibition rate and survival prolongation rate. The results showed that Pinellia ternata polysaccharide had some tumour inhibitory effect. Tumour weight of Pinellia ternata polysaccharide high-dose group was highly significantly different (P<0.01) compared with the model group. Tumour weight between Pinellia ternata polysaccharide medium-dose group and model group also had a significant difference (P<0.05). Moreover, in the Pinellia ternata polysaccharide high-dose group, survival prolongation rate of ascites tumour mice reached 62.23%, and mouse serum SOD, MDA and GSH-Px levels also rose in varying degrees. The study concluded that Pinellia ternata polysaccharide extract had some in vivo anti-tumour effects, which were probably associated with the enhancement of the body's ability to scavenge excess free radicals by improving the body's enzyme activity.
authors: Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Xiaogang
authors: X
authors: Li
authors: Department of Vascular Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Ping
authors: P
authors: Lu
authors: Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Wanfu
authors: W
authors: Zhang
authors: Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Bo
authors: B
authors: Li
authors: Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Rong
authors: R
authors: Yang
authors: Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China.
authors: Kaiyuan
authors: K
authors: Luo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D030021:Pinellia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010936:Plant Extracts; D011134:Polysaccharides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: GSH-Px; MDA; Pinellia ternata polysaccharide; SOD; ascites tumour