title: Relationship of meeting physical activity guidelines with health-related utility.
abstract: OBJECTIVE
  Health-related utility measures overall health status and quality of life and is commonly incorporated into cost-effectiveness analyses. This study investigates whether attainment of federal physical activity guidelines translates into better health-related utility in adults with or at risk for knee osteoarthritis (OA).
  
  
  METHODS
  Cross-sectional data from 1,908 adults with or at risk for knee OA participating in the accelerometer ancillary study of the Osteoarthritis Initiative were assessed. Physical activity was measured using 7 days of accelerometer monitoring and was classified as 1) meeting guidelines (≥150 bouted moderate-to-vigorous [MV] minutes per week); 2) insufficiently active (≥1 MV bout[s] per week but below guidelines); or 3) inactive (zero MV bouts per week). A Short Form 6D health-related utility score was derived from patient-reported health status. Relationship of physical activity levels to median health-related utility adjusted for socioeconomic and health factors was tested using quantile regression.
  
  
  RESULTS
  Only 13% of participants met physical activity guidelines, and 45% were inactive. Relative to the inactive group, median health-related utility scores were significantly greater for the meeting guidelines group (0.063; 95% confidence interval [95% CI] 0.055, 0.071) and the insufficiently active group (0.059; 95% CI 0.054, 0.064). These differences showed a statistically significant linear trend and strong cross-sectional relationship with physical activity level even after adjusting for socioeconomic and health factors.
  
  
  CONCLUSIONS
  We found a significant positive relationship between physical activity level and health-related utility. Interventions that encourage adults, including persons with knee OA, to increase physical activity even if recommended levels are not attained may improve their quality of life.
authors: Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors: Kai
authors: K
authors: Sun
authors: Jing
authors: J
authors: Song
authors: Jungwha
authors: J
authors: Lee
authors: Rowland W
authors: RW
authors: Chang
authors: Charles B
authors: CB
authors: Eaton
authors: Linda
authors: L
authors: Ehrlich-Jones
authors: Kent C
authors: KC
authors: Kwoh
authors: Larry M
authors: LM
authors: Manheim
authors: Pamela A
authors: PA
authors: Semanik
authors: Leena
authors: L
authors: Sharma
authors: Min-Woong
authors: MW
authors: Sohn
authors: Dorothy D
authors: DD
authors: Dunlop
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D019983:Guideline Adherence; D006304:Health Status; D006801:Humans; D008297:Male; D020370:Osteoarthritis, Knee / Q000191:economics / Q000517:prevention & control*