title: Protection against Cu(II)-induced oxidative stress and toxicity to Chlorella vulgaris by 2,2'-Bipyridine-5,5'-dicarboxylic acid.
abstract: In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). Both in vivo and in vitro tests were performed. Different addition orders of Bpy-COOH and Cu(II) were tried in the former, whereas different Bpy-COOH concentrations were used in both experiments. The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). Based on these results, it could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes.
authors: Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Yuhangtang Road #866, Hangzhou, 310058, China, wenyuezhong@zju.edu.cn.
authors: Yuezhong
authors: Y
authors: Wen
authors: Xiaolin
authors: X
authors: Sheng
authors: Shufang
authors: S
authors: Song
authors: Lina
authors: L
authors: Li
authors: Weiping
authors: W
authors: Liu
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D048408:Chlorella vulgaris / Q000187:drug effects* / Q000502:physiology; D003300:Copper / Q000633:toxicity*; D003998:Dicarboxylic Acids / Q000737:chemistry; D018384:Oxidative Stress; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D002614:Chelating Agents; D003998:Dicarboxylic Acids; D014874:Water Pollutants, Chemical; D015082:2,2'-Dipyridyl; D003300:Copper