title: Does reduced creatine synthesis protect against statin myopathy?
abstract: Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined.
authors: Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA.
authors: Kevin D
authors: KD
authors: Ballard
authors: Paul D
authors: PD
authors: Thompson
mesh_terms: D000579:Amidinotransferases / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D009135:Muscular Diseases / Q000139:chemically induced*; D040641:Quantitative Trait Loci / Q000235:genetics*; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D000579:Amidinotransferases