title: Serum lipoprotein(a) complexes with beta2-glycoprotein I levels in patients with ischemic stroke.
abstract: BACKGROUND
  We investigated serum lipoprotein(a) complexes with beta2-glycoprotein I [β2-GPI-Lp(a)] levels in ischemic stroke patients.
  
  
  METHODS
  Serum β2-GPI-Lp(a), oxidized Lp(a) [ox-Lp(a)] and Lp(a) levels were determined in 124 ischemic stroke patients and 64 normal controls. The severity and clinical outcome of ischemic stroke patients were evaluated by the National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI), respectively. The correlation analysis and multiple linear regression analysis were performed.
  
  
  RESULTS
  Compared with controls, serum β2-GPI-Lp(a), ox-Lp(a) and Lp(a) levels were significantly increased in ischemic stroke patients, and their levels were higher in severe stroke than in mild stroke. The β2-GPI-Lp(a) levels were positively related with ox-Lp(a) (r=0.665, P=0.000) and Lp(a) (r=0.195, P=0.035). NIHSS scores were positively correlated with β2-GPI-Lp(a) (r=0.322, P=0.000), while BI was negatively related with β2-GPI-Lp(a) (r=-0.301, P=0.012). Multiple linear regression analyses showed that β2-GPI-Lp(a) (β coefficient=0.338, P=0.010) and ox-Lp(a) (β coefficient=0.265, P=0.043) were found to account for 25.1% of the variation of NIHSS scores, and that only β2-GPI-Lp(a) (β coefficient=-0.351, P=0.005; adjusted R(2)=0.108) was an independent predictor of BI.
  
  
  CONCLUSIONS
  Serum β2-GPI-Lp(a) levels were increased in ischemic stroke patients. Elevated β2-GPI-Lp(a) levels were associated with the severity and clinical outcome of ischemic stroke.
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Lijuan
authors: L
authors: Ma
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Jia
authors: J
authors: Wu
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Dongmei
authors: D
authors: Niu
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Ruijie
authors: R
authors: Yu
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Jiaxi
authors: J
authors: Song
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
authors: Chunni
authors: C
authors: Zhang
authors: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China. Electronic address: jjwang9202@gmail.com.
authors: Junjun
authors: J
authors: Wang
mesh_terms: D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D020521:Stroke / Q000097:blood* / Q000150:complications*; D053482:beta 2-Glycoprotein I / Q000097:blood* / Q000378:metabolism*
chemical_list: D017270:Lipoprotein(a); D053482:beta 2-Glycoprotein I
keywords: Atherosclerosis; Beta2-glycoprotein I; Ischemic stroke; Lipoprotein(a); Oxidation