title: On the inhibitory effect of Drynaria fortunei extract on human myeloma SP20 cells.
abstract: The objective of the study was to investigate the inhibitory effect of Drynaria fortunei extract on human myeloma SP2 cells. Three different total extracts of Drynaria fortunei were obtained by reflux extraction method using different organic solvents including ethanol, methanol and petroleum ether. Their anticancer activities on SP20 cells were tested, and the maximum inhibition rate was obtained. The inhibitory effects on tumour cells at 12 h, 24 h, 36 h and 48 h were tested, and the inhibition curves at different time periods were plotted. The results showed that the methanol and ethanol extracts have similar inhibition rates at 24 h, which are around 55%. On the other hand, the maximum inhibition rate of petroleum ether extract is only 36% within 24 h. Moreover, within the time periods of 36 h and 48 h, its inhibition rates are all below 10%.
authors: Orthopaedics Department, The Affiliated hospital of Shandong University of Traditional Chinese Medicine, 250014, Ji Nan, China.
authors: Baofeng
authors: B
authors: Li
authors: Tingting
authors: T
authors: Duan
authors: Lei
authors: L
authors: Fan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D029621:Polypodiaceae; D012997:Solvents
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012997:Solvents
keywords: Drynaria fortunei; Flavonoid compounds; Inhibitory; Mouse SP2/0 tumour