title: Attenuating effects of omega-3 fatty acids (Omegaven) on irradiation-induced intestinal injury in mice.
abstract: Gastrointestinal injury is a major cause of death following exposure to high levels of irradiation, and no effective treatments are currently available. In this study, we examined the effect of omega-3 fatty acids (Omegaven) on intestinal injury of BALB/c mice induced by irradiation. Intravenously administered 3 days prior to irradiation for 7 consecutive days, Omegaven was shown to improve survival, intestinal morphology including villous height, crypt height and mucosal thickness and the intestinal proliferation compared with saline control. Omegaven also normalized the levels of circulating tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), attenuated the increase of diamino oxidase (DAO) activity and malondialdehyde (MDA) level and recovered the decrease of superoxide dismutase (SOD) activity. Meanwhile, Omegaven attenuated the myelosuppression caused by irradiation. In conclusion, our results suggest that Omegaven enhanced the survival of irradiated mice and minimized the effects of radiation on gastrointestinal injury.
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Mingli
authors: M
authors: Sun
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Lei
authors: L
authors: Pang
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Xuepeng
authors: X
authors: Ju
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Haigang
authors: H
authors: Sun
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Jiankun
authors: J
authors: Yu
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Haishan
authors: H
authors: Zhao
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China.
authors: Weifan
authors: W
authors: Yao
authors: Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, PR China. Electronic address: mjwei@mail.cmu.edu.cn.
authors: Minjie
authors: M
authors: Wei
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D005395:Fish Oils / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000528:radiation effects*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014916:Whole-Body Irradiation
chemical_list: D005395:Fish Oils; D015850:Interleukin-6; D011837:Radiation-Protective Agents; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C568345:fish oil triglycerides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D006631:Amine Oxidase (Copper-Containing)
keywords: Intestine injury; Irradiation; Omegaven; Survival