title: Dynamic pulmonary computed tomography angiography: a new standard for evaluation of combined airway and vascular abnormalities in infants.
abstract: Airway abnormalities are frequently associated with congenital heart disease in infants and children. Respiratory distress in these children frequently requires prolonged respiratory support. Wide-detector dynamic pulmonary computed tomography angiography (DP-CTA) is a non-invasive technique that completely evaluates vascular and airway abnormalities during a single breathe. Our purpose was to evaluate the efficacy of DP-CTA to provide unique actionable information for patient care in newborns and infants with congenital heart disease and persistent respiratory distress. 23 infants with congenital heart disease and persistent respiratory distress underwent DP-CTA. All were intubated at the time of the examinations. The most common cardiac anomalies were tetralogy of Fallot (6) and hypoplastic left heart syndrome variants (5). The most common cardiac surgeries prior to DP-CTA were Norwood (4) and hybrid (3) procedures. The protocol for DP-CTA for intubated infants is four gantry rotations in 1.4 s after intravenous contrast injection. 3D and multiplanar reconstruction with cine loops were created for combined cardiopulmonary imaging. Tracheobronchomalacia was present in 17 children. Lobar bronchomalacia was identified in six children. Branch pulmonary artery stenosis was the most common vascular finding (10 children). Medical management was changed or a surgical procedure performed based on the information resulting from DP-CTA in 16 of the 23 patients (70 %). DP-CTA is non-invasive, fast and provides unique information for the management of infants with congenital heart disease and persistent respiratory distress. DP-CTA is uniquely suited for comprehensive and simultaneous evaluation of airway and vascular abnormalities in infants.
authors: Arkansas Children's Hospital, 1 Children's Way, Slot #105, Little Rock, AR, 72202, USA, greenbergsbruce@uams.edu.
authors: S Bruce
authors: SB
authors: Greenberg
authors: Umesh
authors: U
authors: Dyamenahalli
mesh_terms: D000015:Abnormalities, Multiple; D006348:Cardiac Surgical Procedures; D002932:Cineangiography; D003251:Constriction, Pathologic; D003287:Contrast Media / Q000008:administration & dosage; D006330:Heart Defects, Congenital / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000601:surgery; D012119:Respiration; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055089:Tracheobronchomalacia / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D054079:Vascular Malformations / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D003287:Contrast Media