title: CT assessment of liver hemodynamics in patients with hepatocellular carcinoma after argon-helium cryoablation.
abstract: BACKGROUND
  Assessment of tumor response after argon-helium cryoablation is critical in guiding future therapy for unresectable hepatocellular carcinoma. This study aimed to evaluate liver hemodynamics in hepatocellular carcinoma after argon-helium cryoablation with computed tomography perfusion.
  
  
  METHODS
  The control group comprised 40 volunteers without liver disease. The experimental group was composed of 15 patients with hepatocellular carcinoma treated with argon-helium cryoablation. Computed tomography perfusion parameters were measured: hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, hepatic arterial perfusion, and hepatic portal perfusion.
  
  
  RESULTS
  After treatment, in the tumor foci, permeability of capillary vessel surface was higher, and hepatic blood flow, hepatic blood volume, hepatic arterial fraction, and hepatic arterial perfusion values were lower (P<0.05). In the liver parenchyma surrounding the tumor, hepatic arterial perfusion was significantly lower (P<0.05); however, there was no significant difference in hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, or hepatic portal perfusion (P>0.05).
  
  
  CONCLUSIONS
  Computed tomography perfusion can evaluate tumor response after argon-helium cryoablation.
authors: Department of Radiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China. jhjemail@163.com.
authors: Xue-Jia
authors: XJ
authors: Hao
authors: Jin-Ping
authors: JP
authors: Li
authors: Hui-Jie
authors: HJ
authors: Jiang
authors: Da-Qing
authors: DQ
authors: Li
authors: Zai-Sheng
authors: ZS
authors: Ling
authors: Li-Ming
authors: LM
authors: Xue
authors: Guang-Long
authors: GL
authors: Feng
mesh_terms: D001128:Argon; D001810:Blood Volume / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D016022:Case-Control Studies; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006371:Helium; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000098:blood supply*; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D006371:Helium; D001128:Argon