title: Restoration of albumin production by nucleoside analogue therapy in patients with chronic hepatitis B.
abstract: The clinical course of patients with chronic hepatitis B (CH-B) was greatly changed by the introduction of nucleoside analogues. We often encounter patients where the serum level of albumin recovers quickly following the treatment. In this study, we focused carefully on the changes in serum albumin level noted during nucleoside analogue therapy, in an effort to clarify the mechanism behind the restoration of albumin production. We observed changes in serum albumin levels during nucleoside analogue therapy in 12 patients with CH-B and studied the mechanism behind the restoration of albumin production following the therapy. The serum level of albumin was significantly increased very soon after the treatment was started. Prior to treatment with nucleoside analogues, the albumin signal for mRNA was only slightly seen in the peri-portal area, whereas 12 months after the treatment, the liver tissue presented an obvious signal of albumin mRNA. Serum levels of hepatocyte growth factor (HGF) were significantly decreased 12 months after the treatment. In this study, we demonstrated that nucleoside analogues decrease HGF through the suppression of hepatocyte damage, leading to the restoration of albumin production in patients with CH-B.
authors: Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico City, Mexico.
authors: Mineko
authors: M
authors: Shibayama
authors: Jesus
authors: J
authors: Serrano-Luna
authors: Tetsuro
authors: T
authors: Sohda
authors: Motoko
authors: M
authors: Kawashima
authors: Eri
authors: E
authors: Yamauchi
authors: Takashi
authors: T
authors: Tanaka
authors: Shu-Ichi
authors: S
authors: Ueda
authors: Daisuke
authors: D
authors: Morihara
authors: Akira
authors: A
authors: Anan
authors: Yasuaki
authors: Y
authors: Takeyama
authors: Makoto
authors: M
authors: Irie
authors: Kaoru
authors: K
authors: Iwata
authors: Satoshi
authors: S
authors: Shakado
authors: Shotaro
authors: S
authors: Sakisaka
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D015870:Gene Expression; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000188:drug therapy; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000235:genetics / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000097:blood; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; C066855:HGF protein, human; D012709:Serum Albumin; D053773:Transforming Growth Factor beta1; D019259:Lamivudine; C413685:entecavir; D006147:Guanine; D017228:Hepatocyte Growth Factor