title: [Risk factors of hepatorenal syndrome in patients with acute on chronic liver failure].
abstract: OBJECTIVE
  To identify the risk factors of hepatorenal syndrome in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure(ACLF).
  
  
  METHODS
  A total of 726 hospitalized patients with HBV-ACLF were retrospectively analyzed. Data of demographic and clinical parameters (sex, age, family history, and presence of liver cirrhosis and diabetes), common complications (spontaneous bacterial peritonitis, pulmonary infection, hepatic encephalopathy, and upper gastrointestinal hemorrhage), and baseline biochemical parameters (albumin, globulin, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, cholesterol, cholinesterase, K+, Na+, plasma thromboplastin antecedent, alpha-fetoprotein, HBV DNA, white blood cell count, hemoglobin, and platelet count) were collected from the medical records database. Univariate and multiple regression analyses were performed to determine the risk factors of hepatorenal syndrome.
  
  
  RESULTS
  Multiple logistic regression analysis indicated that upper gastrointestinal hemorrhage [risk (R) = 1.313, relative hazard (RH) = 3.716, 95% confidence interval (CI): 2.156-6.404], hepatic encephalopathy (R = 1.120, RH = 3.065, 95% CI: 1.900-4.945), spontaneous bacterial peritonitis (R = 1.005, RH = 2.733, 95% CI: 1.379-5.417), pulmonary infection (R = 1.051, RH = 2.862, 95% CI: 1.783-4.592), and white blood cell count (R = 0.056, RH = 1.058, 95% CI: 1.010-1.107) were independent risk factors for hepatorenal syndrome development in patients with HBV-ACLF.
  
  
  CONCLUSIONS
  Several risk factors were significantly associated with the development of hepatorenal syndrome in HBV-ACLF, including upper gastrointestinal hemorrhage, hepatic encephalopathy, spontaneous bacterial peritonitis, pulmonary infection, and elevated white blood cell count.
authors: Live Disease Division of Fuzhou Infectious Diseases Hospital, Fuzhou 350025, China.
authors: Dong-qing
authors: DQ
authors: Zhang
authors: Li
authors: L
authors: Chen
authors: Qiao-rong
authors: QR
authors: Gan
authors: Qing-feng
authors: QF
authors: Lin
authors: Chen
authors: C
authors: Pan
mesh_terms: D000328:Adult; D015984:Causality; D058625:End Stage Liver Disease / Q000150:complications*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D006530:Hepatorenal Syndrome / Q000209:etiology*; D006801:Humans; D017093:Liver Failure / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors