title: Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified.
abstract: Coxsackievirus A16 (CVA16) is responsible for nearly 50% of all the conﬁrmed hand, foot, and mouth disease (HFMD) cases in mainland China, sometimes it could also cause severe complications, and even death. To clarify the genetic characteristics and the epidemic patterns of CVA16 in mainland China, comprehensive bioinfomatics analyses were performed by using 35 CVA16 whole genome sequences from 1998 to 2011, 593 complete CVA16 VP1 sequences from 1981 to 2011, and prototype strains of human enterovirus species A (EV-A). Analysis on complete VP1 sequences revealed that subgenotypes B1a and B1b were prevalent strains and have been co-circulating in many Asian countries since 2000, especially in mainland China for at least 13 years. While the prevalence of subgenotype B1c (totally 20 strains) was much limited, only found in Malaysia from 2005 to 2007 and in France in 2010. Genotype B2 only caused epidemic in Japan and Malaysia from 1981 to 2000. Both subgenotypes B1a and B1b were potential recombinant viruses containing sequences from other EV-A donors in the 5'-untranslated region and P2, P3 non-structural protein encoding regions.
authors: Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P. R. of China.
authors: Xiangpeng
authors: X
authors: Chen
authors: Xiaojuan
authors: X
authors: Tan
authors: Jing
authors: J
authors: Li
authors: Yu
authors: Y
authors: Jin
authors: Liming
authors: L
authors: Gong
authors: Mei
authors: M
authors: Hong
authors: Yonglin
authors: Y
authors: Shi
authors: Shuangli
authors: S
authors: Zhu
authors: Baomin
authors: B
authors: Zhang
authors: Shuang
authors: S
authors: Zhang
authors: Yong
authors: Y
authors: Zhang
authors: Naiying
authors: N
authors: Mao
authors: Wenbo
authors: W
authors: Xu
mesh_terms: D020121:5' Untranslated Regions; D001483:Base Sequence; D002681:China; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods*; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis*; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D016679:Genome, Viral; D023281:Genomics; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D020121:5' Untranslated Regions; D017931:DNA Primers; D004279:DNA, Viral