title: Replicability and heterogeneity of awake unrestrained canine FMRI responses.
abstract: Previously, we demonstrated the possibility of fMRI in two awake and unrestrained dogs. Here, we determined the replicability and heterogeneity of these results in an additional 11 dogs for a total of 13 subjects. Based on an anatomically placed region-of-interest, we compared the caudate response to a hand signal indicating the imminent availability of a food reward to a hand signal indicating no reward. 8 of 13 dogs had a positive differential caudate response to the signal indicating reward. The mean differential caudate response was 0.09%, which was similar to a comparable human study. These results show that canine fMRI is reliable and can be done with minimal stress to the dogs.
authors: Center for Neuropolicy, Emory University, Atlanta, Georgia, United States of America.
authors: Gregory S
authors: GS
authors: Berns
authors: Andrew
authors: A
authors: Brooks
authors: Mark
authors: M
authors: Spivak
mesh_terms: D000818:Animals; D004285:Dogs; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012149:Restraint, Physical; D012201:Reward; D014851:Wakefulness / Q000502:physiology*