title: Comparative effectiveness of treatment options for pediatric craniopharyngiomas.
abstract: OBJECTIVE
  No clear treatment guidelines for pediatric craniopharyngiomas exist. The authors developed a decision analytical model to evaluate outcomes of 4 surgical approaches for craniopharyngiomas in children, including attempted gross-total resection (GTR), planned subtotal removal plus radiotherapy, biopsy plus radiotherapy, and endoscopic resections of all kinds.
  
  
  METHODS
  Pooled data, including the authors' own experience, were used to create evidence tables, from which incidence, relative risks, and summary outcomes in quality-adjusted life years (QALYs) were calculated for the 4 management strategies.
  
  
  RESULTS
  Quality-adjusted life years at the 5-year follow-up were 2.3 ± 0.1 for attempted GTR, 2.9 ± 0.2 for planned subtotal removal plus radiotherapy, 3.9 ± 0.2 for biopsy plus radiotherapy, and 3.7 ± 0.2 for endoscopic resection (F = 17,150, p < 0.001). Similarly, QALYs at 10-year follow-up were 4.5 ± 0.2 for attempted GTR, 5.7 ± 0.5 for planned subtotal removal plus radiotherapy, and 7.8 ± 0.5 for biopsy plus radiotherapy (F = 6,173, p < 0.001). On post hoc pairwise comparisons, the differences between all pairs compared were also highly significant (p < 0.001). Since follow-up data at 10 years are lacking for endoscopic cases, this category was excluded from 10-year comparisons.
  
  
  CONCLUSIONS
  Biopsy with subsequent radiotherapy is the preferred approach with respect to improved overall quality of life. While endoscopic approaches also show promise in preserving quality of life at five-year follow-up, there are not sufficient data to draw conclusions about this comparison at 10 years.
authors: Department of Neurosurgery, University of Pennsylvania; and.
authors: Zarina S
authors: ZS
authors: Ali
authors: Robert L
authors: RL
authors: Bailey
authors: Lawrence B
authors: LB
authors: Daniels
authors: Venus
authors: V
authors: Vakhshori
authors: Daniel J
authors: DJ
authors: Lewis
authors: Alisha T
authors: AT
authors: Hossain
authors: Karlyndsay Y
authors: KY
authors: Sitterley
authors: John Y K
authors: JY
authors: Lee
authors: Phillip B
authors: PB
authors: Storm
authors: Gregory G
authors: GG
authors: Heuer
authors: Sherman C
authors: SC
authors: Stein
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000473:pathology / Q000532:radiotherapy*; D003661:Decision Support Techniques; D003663:Decision Trees; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010911:Pituitary Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012306:Risk; D016896:Treatment Outcome