title: Two new ylangene-type sesquiterpenoids from cultures of the fungus Postia sp.
abstract: Two new ylangene-type sesquiterpenoids, postinins A (1) and B (2), were isolated from cultures of the fungus Postia sp. Structures 1 and 2 were elucidated on the basis of extensive spectroscopic analysis. The bioactivity evaluation showed that both compounds had significant inhibitory activities against protein tyrosine phosphatase 1B, and SH2-containing cytoplasmic tyrosine phosphatase-1 and -2 with IC₅₀ values of 1.6-6.2 μg/ml.
authors: a College of Life Science, Hebei Normal University , Shijiazhuang , 050024 , China.
authors: Qiong-Ying
authors: QY
authors: Fan
authors: Ze-Jun
authors: ZJ
authors: Dong
authors: Zheng-Hui
authors: ZH
authors: Li
authors: Xia
authors: X
authors: Yin
authors: Xiao-Yan
authors: XY
authors: Yang
authors: Tao
authors: T
authors: Feng
authors: Kun
authors: K
authors: Wei
authors: Ji-Kai
authors: JK
authors: Liu
authors: Bao-Hua
authors: BH
authors: Zhao
mesh_terms: D000818:Animals; D055453:Coriolaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; C587270:postinin A; C587271:postinin B; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1