title: Two new isoflavone glycosides from the vine stem of Millettia dielsiana.
abstract: Two new isoflavone glycosides, millesianins F (1) and G (2), along with 11 known ones (3-13) have been isolated from the n-butanol extract of the vine stems of Millettia dielsiana Harms. The structures of 1 and 2 were established as cladrastin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (1) and fujikinetin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (2) by means of spectroscopic analysis and chemical methods. Some isolates (compounds 1, 3, 4, 5, 6, and 11) were tested for their effects on the proliferation of hematopoietic progenitor cell, and the preliminary results showed that all of investigated compounds had moderate activities but not in dose-dependent manners.
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China.
authors: Ting
authors: T
authors: Gong
authors: Ting
authors: T
authors: Zhang
authors: Dong-xiao
authors: DX
authors: Wang
authors: Ruo-yun
authors: RY
authors: Chen
authors: Ping
authors: P
authors: Liu
authors: De-quan
authors: DQ
authors: Yu
mesh_terms: D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006412:Hematopoietic Stem Cells; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D007529:Isoflavones; C587149:millesianin F; C587150:millesianin G