title: Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.
abstract: OBJECTIVE
  We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.
  
  
  METHODS
  Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.
  
  
  RESULTS
  TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.
  
  
  CONCLUSIONS
  TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.
authors: Department of Global Health.
authors: Romel D
authors: RD
authors: Mackelprang
authors: Abigail W
authors: AW
authors: Bigham
authors: Connie
authors: C
authors: Celum
authors: Guy
authors: G
authors: de Bruyn
authors: Kristin
authors: K
authors: Beima-Sofie
authors: Grace
authors: G
authors: John-Stewart
authors: Allan
authors: A
authors: Ronald
authors: Nelly R
authors: NR
authors: Mugo
authors: Kati J
authors: KJ
authors: Buckingham
authors: Michael J
authors: MJ
authors: Bamshad
authors: James I
authors: JI
authors: Mullins
authors: M Juliana
authors: MJ
authors: McElrath
authors: Jairam R
authors: JR
authors: Lingappa
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D019143:Evolution, Molecular; D014644:Genetic Variation; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology / Q000821:virology; D015497:HIV-1; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D051193:Toll-Like Receptors / Q000235:genetics*; D019562:Viral Load; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D051193:Toll-Like Receptors
keywords: Acute Infection; Genetics; HIV-1 acquisition; HIV-1 set-point; Heterosexual HIV-1 transmission; Progression; Risk Factors; Toll-like Receptors; Viral load