title: Effect of side-stream smoking on random-pattern skin flap survival in rats.
abstract: The secondhand exposure to cigarette smoke is being considered evil, and damage caused by this passive exposure has been proven by several studies. To investigate the effects of sidestream smoke exposure on random-pattern skin flap survival, 20 female rats were separated into 2 groups: group A (n = 10) was exposed 6 weeks to the smoke from the burning cigarette (passive smoking) and group B (n = 10) was the control group. After 6 weeks of exposition, a dorsal McFarlane flap of 4 × 10 cm was performed in all rats. Two weeks after this procedure, the ratio of necrotic and total areas was calculated using computer programs. The median area of necrosis in group A was 29.5%, significantly higher than that in group B with 17.5% (P < 0.024). In conclusion, this study suggests increased risk of random-pattern skin flap necrosis after sidestream exposure to cigarette smoke.
authors: From the *Division of Hand Surgery and Reconstructive Microsurgery, Hospital São Lucas, and †School of Medicine at the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors: Anajara
authors: A
authors: Gazzalle
authors: Lourenço Frigeri
authors: LF
authors: Teixeira
authors: Alice Cardoso
authors: AC
authors: Pellizzari
authors: Fernanda
authors: F
authors: Cocolichio
authors: Juliana Tonietto
authors: JT
authors: Zampieri
authors: Daniel
authors: D
authors: Rauber
authors: Luíse S
authors: LS
authors: Pezzin
authors: Vanessa D
authors: VD
authors: Zago
authors: Jefferson Luis
authors: JL
authors: Braga-Silva
mesh_terms: D000818:Animals; D005260:Female; D006085:Graft Survival; D009336:Necrosis / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013524:Surgical Flaps / Q000473:pathology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution