title: Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model.
abstract: Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.
authors: Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
authors: Megan A
authors: MA
authors: O'Connor
authors: William R
authors: WR
authors: Green
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004586:Electrophoresis; D017988:Gammaretrovirus / Q000235:genetics / Q000276:immunology*; D050838:Interferon Regulatory Factor-3 / Q000235:genetics*; D050839:Interferon Regulatory Factor-7 / Q000235:genetics*; D007370:Interferon Type I / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D011506:Proteins / Q000235:genetics / Q000276:immunology; D013045:Species Specificity; D018709:Statistics, Nonparametric
chemical_list: C103189:Fv1 protein, mouse; D050838:Interferon Regulatory Factor-3; D050839:Interferon Regulatory Factor-7; D007370:Interferon Type I; D011506:Proteins