title: Is there a need to redefine the diagnostic criteria for common variable immunodeficiency?
abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased serum levels of immunoglobulins and abnormal antibody response to protein and/or polysaccharide antigens, leading to recurrent respiratory and gastrointestinal infections, autoimmunity and malignancies. Meanwhile, several monogenic defects with CVID-like phenotype have been identified during the last decade. There is a need to reach international consensus by modifying criteria for CVID, considering various areas of uncertainty in the field.
authors: Department of Medicine, Division of Infectious Diseases, Immunodeficiency Unit, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.
authors: Mikko
authors: M
authors: Seppänen
authors: Asghar
authors: A
authors: Aghamohammadi
authors: Nima
authors: N
authors: Rezaei
mesh_terms: D000917:Antibody Formation; D017074:Common Variable Immunodeficiency / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D012141:Respiratory Tract Infections / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000276:immunology
chemical_list: D007136:Immunoglobulins