title: Effect of Acuros XB algorithm on monitor units for stereotactic body radiotherapy planning of lung cancer.
abstract: Stereotactic body radiotherapy (SBRT) is a curative regimen that uses hypofractionated radiation-absorbed dose to achieve a high degree of local control in early stage non-small cell lung cancer (NSCLC). In the presence of heterogeneities, the dose calculation for the lungs becomes challenging. We have evaluated the dosimetric effect of the recently introduced advanced dose-calculation algorithm, Acuros XB (AXB), for SBRT of NSCLC. A total of 97 patients with early-stage lung cancer who underwent SBRT at our cancer center during last 4 years were included. Initial clinical plans were created in Aria Eclipse version 8.9 or prior, using 6 to 10 fields with 6-MV beams, and dose was calculated using the anisotropic analytic algorithm (AAA) as implemented in Eclipse treatment planning system. The clinical plans were recalculated in Aria Eclipse 11.0.21 using both AAA and AXB algorithms. Both sets of plans were normalized to the same prescription point at the center of mass of the target. A secondary monitor unit (MU) calculation was performed using commercial program RadCalc for all of the fields. For the planning target volumes ranging from 19 to 375cm(3), a comparison of MUs was performed for both set of algorithms on field and plan basis. In total, variation of MUs for 677 treatment fields was investigated in terms of equivalent depth and the equivalent square of the field. Overall, MUs required by AXB to deliver the prescribed dose are on an average 2% higher than AAA. Using a 2-tailed paired t-test, the MUs from the 2 algorithms were found to be significantly different (p < 0.001). The secondary independent MU calculator RadCalc underestimates the required MUs (on an average by 4% to 5%) in the lung relative to either of the 2 dose algorithms.
authors: Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Electronic address: rao.khan@albertahealthservices.ca.
authors: Rao F
authors: RF
authors: Khan
authors: Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
authors: Eduardo
authors: E
authors: Villarreal-Barajas
authors: Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
authors: Harold
authors: H
authors: Lau
authors: Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
authors: Hong-Wei
authors: HW
authors: Liu
mesh_terms: D000465:Algorithms; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D016896:Treatment Outcome
keywords: Acuros XB; Analytic anisotropic algorithm; Lung radiotherapy; SBRT planning