title: Antioxidant gene therapy against neuronal cell death.
abstract: Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy.
authors: Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; Department of Toxicology, CINVESTAV-IPN, Mexico City, Mexico.
authors: Juliana
authors: J
authors: Navarro-Yepes
authors: Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Laura
authors: L
authors: Zavala-Flores
authors: Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Annadurai
authors: A
authors: Anandhan
authors: Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Fang
authors: F
authors: Wang
authors: Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Maciej
authors: M
authors: Skotak
authors: Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Namas
authors: N
authors: Chandra
authors: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.
authors: Ming
authors: M
authors: Li
authors: Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, Alexandroupolis, Greece.
authors: Aglaia
authors: A
authors: Pappa
authors: Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City, Mexico.
authors: Daniel
authors: D
authors: Martinez-Fong
authors: Department of Toxicology, CINVESTAV-IPN, Mexico City, Mexico.
authors: Luz Maria
authors: LM
authors: Del Razo
authors: Department of Toxicology, CINVESTAV-IPN, Mexico City, Mexico.
authors: Betzabet
authors: B
authors: Quintanilla-Vega
authors: Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States. Electronic address: rfrancocruz2@unl.edu.
authors: Rodrigo
authors: R
authors: Franco
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D016923:Cell Death; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics; D014780:Viruses / Q000235:genetics
chemical_list: D000975:Antioxidants
keywords: Antioxidant gene therapy; Brain ischemia; Neurodegenerative disorders; Oxidative stress; ROS; Virus-mediated gene delivery