title: Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis.
abstract: OBJECTIVE
  The aim of this study was to examine the expression of several cancer-related long non-coding RNAs (lncRNAs) in patients with tongue squamous cell carcinoma (TSCC) and to explore its clinical significance.
  
  
  METHODS
  A total of 94 TSCC tissue specimens and matched adjacent normal tissue specimens were collected from patients undergoing surgery for TSCC. Differences in the expression of cancer-related lncRNAs were examined via quantitative reverse transcriptase polymerase chain reaction. WST-1 assay and transwell migration assay were carried out to estimate the proliferation and migration abilities of TSCC cells with different expression levels of urothelial cancer-associated 1 (UCA1) lncRNA.
  
  
  RESULTS
  The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells.
  
  
  CONCLUSIONS
  Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis.
authors: Biomedical Research Institute, Shenzhen-Peking University-Hongkong University Science and Technology (PKU-HKUST) Medical Center, Shenzhen, Guangdong Province, China.
authors: Zhengyu
authors: Z
authors: Fang
authors: Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, Guangdong Province, China.
authors: Lamei
authors: L
authors: Wu
authors: Biomedical Research Institute, Shenzhen-Peking University-Hongkong University Science and Technology (PKU-HKUST) Medical Center, Shenzhen, Guangdong Province, China.
authors: Luo
authors: L
authors: Wang
authors: Biomedical Research Institute, Shenzhen-Peking University-Hongkong University Science and Technology (PKU-HKUST) Medical Center, Shenzhen, Guangdong Province, China.
authors: Yang
authors: Y
authors: Yang
authors: Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, Guangdong Province, China.
authors: Yusheng
authors: Y
authors: Meng
authors: Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, Guangdong Province, China. Electronic address: yanghongyu_1979@163.com.
authors: Hongyu
authors: H
authors: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D054443:Cell Migration Assays; D049109:Cell Proliferation; D005260:Female; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018709:Statistics, Nonparametric; D014062:Tongue Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding; C515159:UCA1 RNA, human