title: Structure modeling using genetically engineered crosslinking.
abstract: Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.
authors: Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
authors: Kuntal
authors: K
authors: Pal
authors: Karsten
authors: K
authors: Melcher
authors: H Eric
authors: HE
authors: Xu
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D018019:Receptors, Corticotropin-Releasing Hormone / Q000737:chemistry* / Q000378:metabolism*; D054832:Urocortins / Q000737:chemistry* / Q000378:metabolism*; D000099052:CRF Receptor, Type 1
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; C576814:UCN protein, human; D054832:Urocortins; D000099052:CRF Receptor, Type 1