title: Peripheral neuropathies during biologic therapies.
abstract: Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with anti-TNF agents. One was peroneal motor neuropathy. The other case was chronic inflammatory demyelinating polyradiculoneuropathy. In addition, we summarize the previous reports on BAPN and discuss their prevalence rate, pathogenesis and management.
authors: a Department of Clinical Immunology and Rheumatology , The Tazuke-Kofukai Medical Research Institute, Kitano Hospital , Osaka , Japan.
authors: Masato
authors: M
authors: Yagita
authors: b Department of Neurology , Kansai Electric Power Hospital , Osaka , Japan.
authors: Toshiaki
authors: T
authors: Hamano
authors: a Department of Clinical Immunology and Rheumatology , The Tazuke-Kofukai Medical Research Institute, Kitano Hospital , Osaka , Japan.
authors: Saori
authors: S
authors: Hatachi
authors: c Department of Dermatology , University of California Davis School of Medicine , Sacramento , CA , USA.
authors: Masaaki
authors: M
authors: Fujita
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use; D007564:Japan; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab
keywords: Biological agents; Peripheral neuropathy