title: [Association between matrix metalloproteinase-10 gene polymorphisms and instability of carotid plaque].
abstract: OBJECTIVE
  To assess the association between 2 single nucleotide polymorphisms (SNPs) located in exonic regions of matrix metalloproteinase-10 (MMP-10) gene and instability of carotid plaques in a Han Chinese population.
  
  
  METHODS
  Five hundred and eighty-five patients were divided into carotid vulnerable plaque group (n=206) and stable plaque group (n=379) based on results of carotid B-mode ultrasonography. The SNPs were genotyped by real-time polymerase chain reaction using an ABI 7300 TaqMan platform.
  
  
  RESULTS
  The distribution of rs17435959 between the two groups was significantly different at both genotypic (GC+CC vs. GG, P=0.006, OR=2.012) and allelic levels (C vs. G, P=0.001,OR=2.160). Above differences have remained significant with binary logistic regression analysis (P=0.007, OR=2.022; P=0.002, OR=2.104). The minor allele frequency of rs17293607 was 0.56%.
  
  
  CONCLUSIONS
  Above findings suggested that rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque in ethnic Chinese Hans. The C allele may be a susceptible predictor for carotid vulnerable plaque.
authors: Department of Neurology, Taizhou Hospital Affiliated to Wenzhou Medical College, Taizhou, Zhejiang 317000, P.R. Chin. jinxp155@aliyun.com.
authors: Feng
authors: F
authors: Zhu
authors: Xiao-ping
authors: XP
authors: Jin
authors: Mi-wu
authors: MW
authors: Huang
authors: Min
authors: M
authors: Zhu
authors: Qiao-ling
authors: QL
authors: Chen
authors: Feng
authors: F
authors: Wang
authors: Xiao-fei
authors: XF
authors: Hu
authors: Wan-fen
authors: WF
authors: Wang
authors: Wei-ling
authors: WL
authors: Li
authors: Cai
authors: C
authors: Li
authors: Zong-ya
authors: ZY
authors: Zhu
authors: Zhou
authors: Z
authors: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D053506:Matrix Metalloproteinase 10 / Q000235:genetics*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000201:enzymology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053506:Matrix Metalloproteinase 10