title: Serological survey of a new type of reovirus in humans in China.
abstract: To evaluate the presence of a new type of reovirus (designated R4) in humans, we determined the prevalence of specific antibodies using a neutralization assay and ELISA. The sera from 97 healthy people and 219 patients in our hospital with measles, hand-foot-and-mouth disease, liver diseases, and diarrhoea were investigated. Although the study population was limited, our data suggested that R4 is widespread in the human population. A significantly higher level of R4-specific antibody in patients than in healthy people is worthy of consideration, since it poses a risk for aggravation of the extant illness by the reovirus.
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: B
authors: B
authors: Bai
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: H
authors: H
authors: Shen
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: Y
authors: Y
authors: Hu
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: J
authors: J
authors: Hou
authors: Treatment and Research Centre for Liver Cancer, 302 Hospital, Beijing,PR China.
authors: Z
authors: Z
authors: Liu
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: R
authors: R
authors: Li
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: Y
authors: Y
authors: Chai
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: W
authors: W
authors: Huang
authors: Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing,PR China.
authors: P
authors: P
authors: Mao
mesh_terms: D000293:Adolescent; D000328:Adult; D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000276:immunology; D064368:Healthy Volunteers; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008457:Measles / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged; D015995:Prevalence; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000453:epidemiology* / Q000276:immunology; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral