title: 7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction.
abstract: Scopolamine (Sco) can induce amyloid β (Aβ) deposition, oxidative stress, synaptic dysfunction, and learning/memory impairment as observed in Alzheimer's disease (AD), the most common form of dementia affecting more than 25 million elderly people worldwide. Herein we explored the protective effect of 7,8-dihydroxyflavone (7,8-DHF) on Sco-induced Aβ deposition, oxidative stress, synaptic dysfunction, and learning/memory defects. Rats were randomly divided into four groups (n=12 for each group). The control group received normal saline (NS); the Sco group received Sco (1 mg/kg per day) intraperitoneally (i.p.) for 2 weeks. Mice in the Sco+7,8-DHF group received 1 mg/kg per day 7,8-DHF i.p. for 2 weeks, followed by Sco (1 mg/kg per day)+1 mg/kg per day 7,8-DHF (i.p.) for another 2 weeks. The 7,8-DHF group received 1 mg/kg per day 7,8-DHF (i.p.) for 4 weeks. Results showed that the supplement of 7,8-DHF significantly reversed Aβ deposition, oxidative stress, synaptic dysfunction, and cognitive defects. Our data suggest that 7,8-DHF might serve as a promising therapeutic candidate for attenuating Sco-induced AD-like pathological dysfuntion.
authors: 1 Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics University of Chinese People's Armed Police Forces , Tianjin, China .
authors: Chong
authors: C
authors: Chen
authors: Xiao-Hong
authors: XH
authors: Li
authors: Sai
authors: S
authors: Zhang
authors: Yue
authors: Y
authors: Tu
authors: Yan-Min
authors: YM
authors: Wang
authors: Hong-Tao
authors: HT
authors: Sun
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D047309:Flavones / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000009:adverse effects*
chemical_list: C485383:6,7-dihydroxyflavone; D047309:Flavones; D012601:Scopolamine