title: [Lipid, adipokine and ghrelin concentrations in myocardial infarction patients with insulin resistance].
abstract: OBJECTIVE
  The estimate insulin resistance in myocardial infarction.
  
  
  METHODS
  The study involved 200 patients with myocardial infarction, in which on the 1st and 12th day of hospitalization measured glucose, insulin, insulin resistance index (IR), lipid profile, the concentration of adipokines and ghrelin.
  
  
  RESULTS
  IR was detected in 77% of patients and was associated with a history of factors of cardiovascular risk, adverse clinical course of the disease, lipid disorders. The most important marker was the level of free fatty acids. High risk associated with increased in 9 times the concentration of free fatty acids in blood plasma. Patients with IR observed increased concentrations of leptin, resistin, and reduced the protective effect of adiponectin. The high specificity and sensitivity characteristic of the concentration of ghrelin: its reduction by 4 times in the acute phase of myocardial infarction increases the risk of MI by 78%.
  
  
  CONCLUSIONS
  Significant risk factors for MI myocardial infarction, along with insulinemia and glycemia, is to increase the concentration of free fatty acids and the disbalance in the system adipokines against deficiency of ghrelin in acute and early recovery periods of the disease. Free fatty acids and ghrelin are promising markers to stratify the risk of insulin myocardial infarction. resistance in patients with myocardial infarction.
authors: O V
authors: OV
authors: Gruzdeva
authors: V N
authors: VN
authors: Karetnikova
authors: O E
authors: OE
authors: Akbasheva
authors: T S
authors: TS
authors: Fedorova
authors: E V
authors: EV
authors: Belik
authors: E I
authors: EI
authors: Palicheva
authors: E G
authors: EG
authors: Uchasova
authors: Iu A
authors: IuA
authors: Dyleva
authors: N G
authors: NG
authors: Brazovskaia
authors: O L
authors: OL
authors: Barbarash
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D054439:Ghrelin; D008055:Lipids