title: [Panton-Valentine leukocidin in patients with chronic wounds. Results from a clinical investigation in 100 patients].
abstract: BACKGROUND
  The toxin Panton-Valentine leukocidin (PVL) produced by S. aureus is known as a virulence factor that leads to severe infections of skin and soft tissue. However the effect of PVL on wound healing is not known yet. Therefore we examined the detection rate of PVL in patients with chronic wounds.
  
  
  METHODS
  The study included 100 patients with chronic wounds of the lower limb. We determined in all S. aureus isolates the presence of the PVL gene using a PCR technique.
  
  
  RESULTS
  Altogether 94% of the patients had a leg ulcer, while 6% had a foot ulcer; 65% were women. PVL was found in two patients. One of the strains was methicillin-resistant (MRSA) and the other was methicillin-sensitive (MSSA).
  
  
  CONCLUSIONS
  In our investigation there was detection rate for PVL of 2% of all S. aureus isolates in patients with chronic wounds of the lower extremities. Although the role of PVL as a virulence factor of S. aureus in wound healing remains unclear, the detection of PVL should be taken as a cause for a consequent topical antimicrobial wound therapy because of the increased risk of serious infections.
authors: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.
authors: C
authors: C
authors: Hammer
authors: P-M
authors: PM
authors: Rath
authors: J
authors: J
authors: Steinmann
authors: M
authors: M
authors: Stoffels-Weindorf
authors: J
authors: J
authors: Klode
authors: J
authors: J
authors: Dissemond
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001427:Bacterial Toxins / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D005098:Exotoxins / Q000032:analysis*; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012883:Skin Ulcer / Q000175:diagnosis / Q000378:metabolism* / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000175:diagnosis / Q000378:metabolism* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D037521:Virulence Factors / Q000032:analysis; D055815:Young Adult
chemical_list: D001427:Bacterial Toxins; D015415:Biomarkers; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors