title: Switchable substrates for analyzing and engineering cellular functions.
abstract: Cellular activity is highly dependent on the extracellular environment, which is composed of surrounding cells and extracellular matrices. This focus review summarizes recent advances in chemically and physically engineered switchable substrates designed to control such cellular microenvironments by application of an external stimulus. Special attention is given to their molecular design, switching strategies, and representative examples for bioanalytical and biomedical applications.
authors: WPI Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan). NAKANISHI.Jun@nims.go.jp.
authors: Jun
authors: J
authors: Nakanishi
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D002465:Cell Movement; D004353:Drug Evaluation, Preclinical; D055664:Electrochemical Techniques; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering
chemical_list: D011108:Polymers
keywords: cell adhesion; cell migration; electrochemistry; photochemistry; tissue engineering