title: [Research on molecular markers for epigenetic changes in myeloid malignancies].
abstract: Novel recurrent somatic mutations have been identified in patients with myeloid malignancies including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Mutations of tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase (IDH)1/2, enhancer of zeste homologue 2 (EZH2) and additional sex combs-like 1 (ASXL1) have been shown to play important roles in the regulation of epigenetic patterning, and may be used as molecular predictors for pathogenesis and clinical outcome for patients with myeloid malignancies.
authors: Department of Hematology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China. wokibb@gmail.com.
authors: Lin
authors: L
authors: Li
authors: Xue-mei
authors: XM
authors: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D019046:Bone Marrow Neoplasms / Q000209:etiology / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D044127:Epigenesis, Genetic; D006801:Humans; D009154:Mutation
chemical_list: D014408:Biomarkers, Tumor; C000717967:DNMT3A protein, human; D000090205:DNA Methyltransferase 3A