title: Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice.
abstract: To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.
authors: Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Yangsan 626-870, Korea.
authors: Shin Ae
authors: SA
authors: Kang
authors: Mi-Kyung
authors: MK
authors: Park
authors: Min Kyoung
authors: MK
authors: Cho
authors: Hak Sun
authors: HS
authors: Yu
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006321:Heart / Q000469:parasitology; D007378:Interleukins / Q000378:metabolism*; D007422:Intestines / Q000469:parasitology; D007816:Larva Migrans, Visceral / Q000276:immunology* / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000469:parasitology; D013154:Spleen / Q000469:parasitology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014114:Toxascaris / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D007378:Interleukins; D000094632:Thymic Stromal Lymphopoietin
keywords: Th1; Th17; Th2; Toxascaris leonina; cytokine; visceral larva migrans (VLM)