title: Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty acids in patients with acute coronary syndrome.
abstract: This study aimed to assess the balance of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS). We enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA), were compared between patients with and without ACS. We also evaluated the balance of serum n-3 to n-6 PUFAs, including EPA/AA and DHA/AA ratios. EPA/AA values were 0.46 ± 0.32 and 0.50 ± 0.32 in the ACS and non-ACS groups, respectively. DHA/AA values were 0.95 ± 0.37 and 0.96 ± 0.41 in the ACS and non-ACS groups, respectively. Next, we divided the patients into 3 groups based on the tertiles of EPA/AA or tertiles of DHA/AA to determine the independent risk factors for ACS. According to multivariate logistic regression analysis, the group with the lowest EPA/AA (≤0.33) had a greater probability of ACS (odds ratio 3.14, 95% confidence interval 1.16 to 8.49), but this was not true for DHA/AA. In conclusion, an imbalance in the ratio of serum EPA to AA, but not in the ratio of DHA to AA, was significantly associated with ACS.
authors: Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors: Yuji
authors: Y
authors: Nishizaki
authors: Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors: Kazunori
authors: K
authors: Shimada
authors: Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
authors: Shigemasa
authors: S
authors: Tani
authors: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
authors: Takayuki
authors: T
authors: Ogawa
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Jiro
authors: J
authors: Ando
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Masao
authors: M
authors: Takahashi
authors: Department of Cardiology, Sempo Takanawa Hospital, Tokyo, Japan.
authors: Masato
authors: M
authors: Yamamoto
authors: Department of Biostatistics, Graduate School of Public Health, The University of Tokyo, Tokyo, Japan.
authors: Tomohiro
authors: T
authors: Shinozaki
authors: Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors: Katsumi
authors: K
authors: Miyauchi
authors: Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
authors: Ken
authors: K
authors: Nagao
authors: Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Atsushi
authors: A
authors: Hirayama
authors: Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
authors: Michihiro
authors: M
authors: Yoshimura
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Issei
authors: I
authors: Komuro
authors: Jichi Medical University, Tochigi, Japan.
authors: Ryozo
authors: R
authors: Nagai
authors: Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: daida@juntendo.ac.jp.
authors: Hiroyuki
authors: H
authors: Daida
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6