title: Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report.
abstract: BACKGROUND
  The porphyrias are a group of disorders of the heme biosynthesis pathway that may present with acute life-threatening attacks, commonly exacerbated by a wide variety of medications. Many newer immunosuppressive medications, which are in use following kidney transplantation, have not been fully explored in acute porphyrias.
  
  
  METHODS
  A 53-year-old woman received a kidney from a deceased donor, after being on hemodialysis for 4 years. Hereditary coproporphyria was diagnosed at age 19 years. We administered tacrolimus, mycophenolate mofetil and steroid immunosuppression. In the immediate post-transplant periods she displayed abdominal pain and transient uroporphyrin elevation in parallel with slightly elevated (15 ng/mL) tacrolimus concentrations. As the target tacrolimus level was achieved, these findings disappeared.
  
  
  CONCLUSIONS
  Tacrolimus, mycophenolate- mofetil, and steroid therapy for hereditery coproporphyri was safe, in the long term.
authors: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary. Electronic address: telkes.gabor@med.semmelweis-univ.hu.
authors: G
authors: G
authors: Telkes
authors: A
authors: A
authors: Pusztai
authors: K
authors: K
authors: Földes
authors: R M
authors: RM
authors: Langer
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D046349:Coproporphyria, Hereditary / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D012307:Risk Factors; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D016559:Tacrolimus