title: Homophilic peptide inhibits growth of malignant murine and human B cells.
abstract: A homophilic peptide from the T15 plasmacytoma inhibits growth of murine and human B cell tumors. This finding confirms the hypothesis that B cell malignancies are driven by a self-binding epitope in the B cell receoptor (BCR) proposed as the pathogenesis of chronic lymphocytic leukemia (CLL).
authors: Department of Microbiology and Immunology, University of Kentucky , Lexington, Kentucky.
authors: Heinz
authors: H
authors: Kohler
authors: Ann Jay
authors: AJ
authors: Bryan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry; D019169:Jurkat Cells; D051379:Mice; D008819:Mice, Nude; D010446:Peptide Fragments / Q000494:pharmacology*; D010954:Plasmacytoma / Q000188:drug therapy*; D054730:Protein Interaction Domains and Motifs; D055503:Protein Multimerization; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D007143:Immunoglobulin Heavy Chains; D010446:Peptide Fragments; D011947:Receptors, Antigen, B-Cell