title: Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome?
abstract: We report on a 78-year old male with a positive family history for pancreatic cancer, who underwent total pancreatectomy for a suspected intraductal papillary mucinous neoplasm with extensive involvement of the main pancreatic duct and multiple branch ducts. The post operative course was uneventful. Macroscopic examination of the specimen revealed multiple solid non-mucinous tumour nodules throughout the main pancreatic duct and within multiple branch ducts. The microscopic appearance of the tumour, in particular its tubulopapillary growth pattern and immunohistochemical mucin profile (MUC1, MUC6 positive; MUC2, MUC5AC negative) were consistent with intraductal tubulopapillary neoplasia (ITPN) showing high-grade dysplasia. No evidence of stromal invasion was identified. To the best of our knowledge, this is the first report on ITPN in a high-risk patient based on a history of familial pancreatic cancer (FPC). The potential association between this entity and the spectrum of neoplastic lesions in FPC should be investigated with particular consideration of the lower biological aggressiveness of ITPN.
authors: Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden, marco.del-chiaro@karolinska.se.
authors: Marco
authors: M
authors: Del Chiaro
authors: Raffaella Pozzi
authors: RP
authors: Mucelli
authors: John
authors: J
authors: Blomberg
authors: Ralf
authors: R
authors: Segersvärd
authors: Caroline
authors: C
authors: Verbeke
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010180:Pancreatectomy; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology*; D013577:Syndrome
chemical_list: D014408:Biomarkers, Tumor