title: Enzymatic formation of a novel cell-adhesive hydrogel based on small peptides with a laterally grafted l-3,4-dihydroxyphenylalanine group.
abstract: We rationally designed a bioadhesive supramolecular hydrogel by introducing L-3,4-dihydroxylphenylalanine (DOPA) groups while properly integrating the enzymatic reactions and self-assembly processes. The effective presence of the catechol groups successfully promoted the adhesion and proliferation of human fibroblast cells.
authors: College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, 30 Puzhunan Road, Nanjing, Jiangsu, China. bingfanghe@ njut.edu.cn.
authors: J X
authors: JX
authors: Xu
authors: Z
authors: Z
authors: Zhou
authors: B
authors: B
authors: Wu
authors: B F
authors: BF
authors: He
mesh_terms: D000268:Adhesiveness; D000269:Adhesives / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D049872:Bivalvia; D002396:Catechols / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012867:Skin / Q000187:drug effects
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D002396:Catechols; D020100:Hydrogels; D010455:Peptides; D011108:Polymers; D004295:Dihydroxyphenylalanine; C034221:catechol