title: The immunogenicity of cells derived from induced pluripotent stem cells.
abstract: With their ability to undergo unlimited self-renewal in culture and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great potential for the treatment of currently incurable diseases. Two hESC-based cell therapies for spinal cord injury and macular degeneration have been advanced into human clinical trials. Despite this rapid progress, one key challenge of hESC-based cell therapy is the allogeneic immune rejection of hESC-derived cells by recipients. This problem could be mitigated by a recent breakthrough in the technology of induced pluripotent stem cells (iPSCs) by nuclear reprogramming of patient-specific somatic cells with defined factors, which could become a renewable source of autologous cells for cell therapy. However, recent studies revealing the abnormal epigenetics, genomic stability and immunogenicity of iPSCs have raised safety concerns over iPSC-based therapy. Recent findings related to the immunogenicity of iPSC derivatives will be summarized in this review.
authors: Xuemei
authors: X
authors: Fu
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D065150:Cellular Reprogramming / Q000276:immunology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000276:immunology* / Q000637:transplantation