title: Synthesis of single-enantiomer bioactive molecules: a brief overview.
abstract: Chiral-center enantiomers have been shown to differ significantly in biological activity, pharmacodynamics, pharmacokinetics and toxicity. New developments in the stereoselective organic synthesis have enriched the vast literature of synthetic methodologies applicable to access natural products as well as bioactive molecules. These compounds also include new drugs, drug candidates and reagents used to explore biological processes. The article reviews the synthesis of optically pure drugs, biologically active intermediates and amino alcohols by using different methods.
authors: Bio-organic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Jammu, India.
authors: Abdul
authors: A
authors: Rouf
authors: S C
authors: SC
authors: Taneja
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C584454:4-hydroxy-6-(3-methylhexa-3,5-dienyl)tetrahydropyran-2-one; D000605:Amino Alcohols; D001592:Benzyl Alcohols; D005231:Fatty Acids, Unsaturated; D005663:Furans; C561379:Ieodomycin A; D007783:Lactones; D011753:Pyrones; C456047:varitriol
keywords: chiral pool; drugs; dynamic kinetic resolution; enzymatic methods; single-enantiomer