title: NMR study of O and N, O-substituted 8-quinolinol derivatives.
abstract: The (1)H and (13)C NMR spectral study of several biologically active derivatives of 8-quinolinol have been made through extensive NMR studies including homodecoupling and 2D-NMR experiments such as COSY-45°, NOESY, and HeteroCOSY. Electron donating resonance and electron withdrawing inductive effect of several groups showed marked changes in chemical shifts of nuclei at the seventh positions of O-substituted quinolinols (2-15). Although in N-alkyl, 8-alkoxyquinolinium halides (16-21), ring A rightly showed low frequency chemical shift values.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi, 74600, Pakistan.
authors: Sobia
authors: S
authors: Mastoor
authors: Shaheen
authors: S
authors: Faizi
authors: Rubeena
authors: R
authors: Saleem
authors: Bina Shaheen
authors: BS
authors: Siddiqui
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D015125:Oxyquinoline / Q000031:analogs & derivatives* / Q000737:chemistry*; D012015:Reference Standards
chemical_list: D015125:Oxyquinoline
keywords: 13C; 1H; 8-quinolinol; COSY-45°; HeteroCOSY; NMR; NOESY; O-dialkyl derivatives; O-substituted quinolinol and N