title: [Distribution of 5-fluorouracil between lymphocytes and blood plasma].
abstract: In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorouracil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.
authors: M A
authors: MA
authors: Stashkevich
authors: E V
authors: EV
authors: Khomutov
authors: O P
authors: OP
authors: Shatova
authors: Iu V
authors: IuV
authors: Dumanskiĭ
authors: I I
authors: II
authors: Zinkovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism*; D001692:Biological Transport; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005472:Fluorouracil / Q000528:radiation effects*; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D061251:Primary Cell Culture
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil