title: Seasonal variation of severe hypoglycemia in hospitalized patients 60 years of age or older presenting to an emergency center hospital between 2004 and 2010.
abstract: OBJECTIVE
  To investigate the seasonal variation of severe hypoglycemia in hospitalized elderly patients.
  
  
  METHODS
  Among the patients hospitalized in our department between 2004 and 2010, we analyzed the records of 67 patients who required emergency admission for severe hypoglycemia and were aged 60 years or older. Comparisons were made between those admitted during the warm season (April-September) and those in the cold season (October-March).
  
  
  METHODS
  The mean age of the 67 patients was 76±8 years, including 45 men and 22 women. Twenty-four patients were admitted in the warm season and 43 patients were admitted in the cold season, with the average annual number being 3.4±1.9 and 6.1±2.8, respectively (p<0.05).
  
  
  RESULTS
  Admissions for patients taking insulin showed no significant difference between the warm and cold season. In contrast, significantly fewer patients taking oral hypoglycemic agents were admitted in the warm season than in the cold season (5 vs. 22, p<0.05). Among them, 26 patients (96%) were taking sulfonylurea, and anorexia associated with acute infections was the main cause of severe hypoglycemia. In the warm season, all of the patients were discharged without complications, while 8 patients had complications in the cold season.
  
  
  CONCLUSIONS
  A seasonal variation regarding hospitalization was observed for severe hypoglycemia among the patients 60 years of age or older, with a higher incidence in the cold season than the warm season, and anorexia related to infections in patients taking sulfonylureas was responsible for this variation. Accordingly, careful management of acute illness is needed for patients using sulfonylureas, especially during the cold season.
authors: Department of General Internal Medicine, Iwate Prefectural Central Hospital, Japan.
authors: Tomoko
authors: T
authors: Hashimoto
authors: Ai
authors: A
authors: Morita
authors: Yo
authors: Y
authors: Hashimoto
authors: Fukuko
authors: F
authors: Yagami
authors: Kazutaka
authors: K
authors: Sakamoto
authors: Masahiko
authors: M
authors: Owada
authors: Takashi
authors: T
authors: Sugawara
authors: Minoru
authors: M
authors: Kawamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003080:Cold Temperature; D004636:Emergency Service, Hospital / Q000639:trends*; D005260:Female; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012621:Seasons; D012720:Severity of Illness Index