title: Cystathionine beta-synthase 844ins68 polymorphism is unrelated to susceptibility to neural tube defects.
abstract: OBJECTIVE
  Cystathionine beta-synthase (CBS) 844ins68 polymorphism has been implicated in the development of neural tube defects (NTDs). However, the results of different studies are inconsistent. Thus, we conducted a meta-analysis to further investigate this association.
  
  
  METHODS
  Published studies were retrieved from PubMed, Embase, China National Knowledge Infrastructure, and Wanfang Data. Studies that evaluated the association between CBS 844ins68 polymorphism and NTD risk among mothers, children, or fathers were included. The pooled odds ratios with 95% confidence interval were calculated using a fixed effects model or a random effects model.
  
  
  RESULTS
  A total of eight studies on mothers (641 cases and 1145 controls), eight studies on children (852 cases and 1912 controls), and five studies (263 cases and 1562 controls) on fathers were included. The meta-analysis revealed no significant association between CBS 844ins68 polymorphism and NTD risk among mothers, children, and fathers under either genetic model.
  
  
  CONCLUSIONS
  The present meta-analysis indicates that CBS 844ins68 polymorphism is not a good predictor of risk for NTDs.
authors: Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
authors: Shengrong
authors: S
authors: Ouyang
authors: Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
authors: Zhuo
authors: Z
authors: Liu
authors: Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
authors: Yuanyuan
authors: Y
authors: Li
authors: Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
authors: Feifei
authors: F
authors: Ma
authors: Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China. Electronic address: wjianxin@gmail.com.
authors: Jianxin
authors: J
authors: Wu
mesh_terms: D016022:Case-Control Studies; D002648:Child; D003541:Cystathionine beta-Synthase / Q000235:genetics*; D005220:Fathers; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D009035:Mothers; D009436:Neural Tube Defects / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: D003541:Cystathionine beta-Synthase
keywords: CBS; CI; Cystathionine beta-synthase; I; Meta-analysis; NTDs; Neural tube defect; OR; Polymorphism; W; confidence interval; cystathionine beta-synthase; insertion mutation of 844ins68; neural tube defects; odds ratio; wild-type of the CBS gene