title: Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy.
abstract: Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4-1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4-1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.
authors: Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA ; The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
authors: Jessica Ann
authors: JA
authors: Chacon
authors: Shari
authors: S
authors: Pilon-Thomas
authors: Amod A
authors: AA
authors: Sarnaik
authors: Laszlo G
authors: LG
authors: Radvanyi
keywords: 4-1BB; CD137; adoptive cell therapy; co-stimulation; melanoma; tumor-infiltrating lymphocytes