title: [Genetic polymorphisms of 10 short tandem repeat loci in Lhasa Tibetans in China].
abstract: OBJECTIVE
  To investigate genetic polymorphisms of 10 short tandem repeats loci (D6S1043, D7S3048, D9S925, D10S2325, D11S2368, D14S608, D15S659, D17S1290, D20S470 and GATA198B05) in Tibetans from Lhasa, China.
  
  
  METHODS
  Following extraction, DNA from 208 unrelated Tibetan individuals was amplified with a self-designed multiplex PCR system. The amplified fragments were separated by electrophoresis on an ABI 3130 Genetic Analyzer and analyzed with GeneMapper®3.2 software.
  
  
  RESULTS
  The distributions of genotype for the 10 STR loci in the population were in accordance with Hardy-Weinberg equilibrium. The polymorphism information component for the 10 loci was 0.750-0.860, the degree of heterozygosity was 0.726-0.865, the discrimination power was 0.919-0.968, and the probability of exclusion was 0.470-0.725. The combined probability of exclusion and combined discrimination power was 0.9998 and 0.999 999 999 997, respectively.
  
  
  CONCLUSIONS
  Above STR loci have high probability of exclusion and discrimination power, which can be used as candidate markers for population genetic research and forensic practice for Tibetans from Lhasa, China.
authors: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China. zhanglin@scu.edu.cn.
authors: Li
authors: L
authors: Yuan
authors: Lei-peng
authors: LP
authors: Shang
authors: Qin-xiang
authors: QX
authors: Liao
authors: Juan
authors: J
authors: Gui
authors: Lin
authors: L
authors: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic