title: Reduced graphene oxide functionalized with a luminescent rare-earth complex for the tracking and photothermal killing of drug-resistant bacteria.
abstract: An antibacterial platform based on multifunctional reduced graphene oxide (rGO) that is responsive to near-infrared (NIR) light has been constructed. By introducing a luminescent Eu(3+) complex and vancomycin for bacteria tracking into one system, this platform could specifically recognize and light up bacteria. Antibacterial activity of this nanoscale construction under NIR illumination was investigated. Upon illumination with NIR light, this nanoscale architecture generates great heat locally, resulting in the death of drug-resistant bacteria. These results indicate that the ability of this nanoscale platform to kill drug-resistant bacteria has great potential for clinical pathogenic bacteria diagnosis and treatment.
authors: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (China), Fax: (+86) 431-85262625; University of Chinese Academy of Sciences, Beijing, 100039 (China).
authors: Xinjian
authors: X
authors: Yang
authors: Zhenhua
authors: Z
authors: Li
authors: Enguo
authors: E
authors: Ju
authors: Jinsong
authors: J
authors: Ren
authors: Xiaogang
authors: X
authors: Qu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D005063:Europium; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry* / Q000494:pharmacology; D056945:Hep G2 Cells; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D049329:Nanostructures; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D010087:Oxides; D005063:Europium; D014640:Vancomycin; D006108:Graphite
keywords: imaging; luminescent complexes; photothermal killing; rare-earth complexes; reduced graphene oxide