title: MicroRNAs in Cerebral Ischemia.
abstract: Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.
authors: Department of Biochemistry, The Stroke Program, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore.
authors: Kai-Ying
authors: KY
authors: Lim
authors: Jia-Hui
authors: JH
authors: Chua
authors: Jun-Rong
authors: JR
authors: Tan
authors: Priyadharshni
authors: P
authors: Swaminathan
authors: Sugunavathi
authors: S
authors: Sepramaniam
authors: Arunmozhiarasi
authors: A
authors: Armugam
authors: Peter Tsun-Hon
authors: PT
authors: Wong
authors: Kandiah
authors: K
authors: Jeyaseelan