title: An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs.
abstract: BACKGROUND
  Biomarkers are useful tools in research and clinical practice where they are often used to detect and monitor differences in the physiological state of an animal. The proteins IGF-1, IGFBP-3, GHR, CRP, SAA, Hp, IFN-α, IFN-γ, TNF-α, IL-1β, IL-6, IL-10, and IL-18 have been proposed as potential biomarkers for monitoring growth in livestock. The objective of this study was to determine whether hepatic gene expression of these proposed biomarkers is associated with growth performance in nursery pigs. Herd information and growth parameters were collected for 168 piglets from 8 commercial farms in southern Ontario. From these pigs, a subset of liver tissue samples (n = 74) was used for gene expression analysis of the proposed biomarkers. Multivariable linear regression methods were used to determine whether genetic expression of the proposed biomarkers was associated with growth performance in the nursery.
  
  
  RESULTS
  Modelling the herd information and individual piglet traits in relation to growth performance revealed that the weight at weaning and the age at weaning are significantly associated with nursery performance. Average daily gain (ADG) was significantly associated with hepatic IGFBP-3 and GHR expression in the liver (P < 0.05), and tended to be associated with hepatic IGF-1 expression (P = 0.071). Similarly, 9-week body weight was significantly associated with hepatic expression of IGFBP-3 and GHR expression (P < 0.05), and tended to be associated with hepatic expression of IGF-1 (P = 0.055).
  
  
  CONCLUSIONS
  The age and weight at which pigs are weaned is an important determinant for nursery performance. Hepatic gene expression of IGF-1, IGFBP-3, and GHR can be useful biomarkers for monitoring growth performance in nursery pigs.
authors: Mackenzie J
authors: MJ
authors: Slifierz
authors: Robert
authors: R
authors: Friendship
authors: Cornelius F M
authors: CF
authors: de Lange
authors: Marko
authors: M
authors: Rudar
authors: Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road, N1G 2 W1 Guelph, Ontario, Canada. afarzan@uoguelph.ca.
authors: Abdolvahab
authors: A
authors: Farzan
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000235:genetics / Q000254:growth & development; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D020869:Gene Expression Profiling; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000502:physiology; D008099:Liver / Q000737:chemistry; D008297:Male; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D011986:Receptors, Somatotropin / Q000032:analysis / Q000502:physiology; D013552:Swine / Q000235:genetics / Q000254:growth & development*
chemical_list: D015415:Biomarkers; D018972:Insulin-Like Growth Factor Binding Protein 3; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I