title: Synthesis and pharmacological activities of some new triazolo- and tetrazolopyrimidine derivatives.
abstract: A new series of fused triazolo- and tetrazolopyrimidine derivatives 2-14 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
authors: Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawara 3893, Saudi Arabia. dr_ahmedfayed14@yahoo.com.
authors: Saleh A
authors: SA
authors: Bahashwan
authors: Ahmed A
authors: AA
authors: Fayed
authors: Abd El-Galil E
authors: Ael-G
authors: Amr
authors: Eman M
authors: EM
authors: Flefel
authors: Atef
authors: A
authors: Kalmouch
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D013777:Tetrazoles; D014230:Triazoles