title: Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division.
abstract: The retinoblastoma (Rb) protein was identified as a human tumour suppressor protein that controls various stages of cell proliferation through the interaction with members of the E2F family of transcription factors. It was originally thought to be specific to animals but plants contain homologues of Rb, called RETINOBLASTOMA-RELATED (RBR). In fact, the Rb-E2F module seems to be a very early acquisition of eukaryotes. The activity of RBR depends on phosphorylation of certain amino acid residues, which in most cases are well conserved between plant and animal proteins. In addition to its role in cell-cycle progression, RBR has been shown to participate in various cellular processes such as endoreplication, transcriptional regulation, chromatin remodelling, cell growth, stem cell biology, and differentiation. Here, we discuss the most recent advances to define the role of RBR in cell proliferation and asymmetric cell division. These and other reports clearly support the idea that RBR is used as a landing platform of a plethora of cellular proteins and complexes to control various aspects of cell physiology and plant development.
authors: Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Nicolas Cabrera 1, 28049 Madrid, Spain bdesvoyes@cbm.csic.es cgutierrez@cbm.csic.es.
authors: Bénédicte
authors: B
authors: Desvoyes
authors: Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Catalonia, Spain.
authors: Alex
authors: A
authors: de Mendoza
authors: Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Catalonia, Spain.
authors: Iñaki
authors: I
authors: Ruiz-Trillo
authors: Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Nicolas Cabrera 1, 28049 Madrid, Spain bdesvoyes@cbm.csic.es cgutierrez@cbm.csic.es.
authors: Crisanto
authors: C
authors: Gutierrez
mesh_terms: D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D049109:Cell Proliferation; D018506:Gene Expression Regulation, Plant; D059828:Plant Cells; D010944:Plants / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; C487568:RBR1 protein, Arabidopsis
keywords: Arabidopsis; Rb plylogenetic tree; asymmetric cell division; cell cycle; gene expression; phosphorylation; plant; retinoblastoma-related (RBR).