title: Complementary strategies for developing Gd-free high-field T₁ MRI contrast agents based on Mn(III) porphyrins.
abstract: Mn(III) porphyrin (MnP) holds the promise of addressing the emerging challenges associated with Gd-based clinical MRI contrast agents (CAs), namely, Gd-related adverse effect and decreasing sensitivity at high clinical magnetic fields. Two complementary strategies for developing new MnPs as Gd-free CAs with optimized biocompatibility were established to improve relaxivity or clearance rate. MnPs with distinct and tunable pharmacokinetic properties can consequently be constructed for different in vivo applications at clinical field of 3 T.
authors: Department of Chemistry, University of Toronto , Toronto, Ontario, M5S 3H6, Canada.
authors: Weiran
authors: W
authors: Cheng
authors: Inga E
authors: IE
authors: Haedicke
authors: Joris
authors: J
authors: Nofiele
authors: Francisco
authors: F
authors: Martinez
authors: Kiran
authors: K
authors: Beera
authors: Timothy J
authors: TJ
authors: Scholl
authors: Hai-Ling Margaret
authors: HL
authors: Cheng
authors: Xiao-An
authors: XA
authors: Zhang
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005682:Gadolinium; D008279:Magnetic Resonance Imaging; D008345:Manganese; D008665:Metalloporphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C587455:(5,10,15,20-tetrakis(carboxy)porphyrinato)manganese(III); C587456:4,4'-bis(manganese(III) 5,10,15-tris(4-sulfonatophenyl)porphin-20-yl)biphenyl; D001713:Biphenyl Compounds; D003287:Contrast Media; D056831:Coordination Complexes; D008665:Metalloporphyrins; D011166:Porphyrins; D008345:Manganese; D005682:Gadolinium