title: Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery.
abstract: OBJECTIVE
  The PartoSure time-to-delivery (TTD) test (AmniSure International, Boston, MA, USA) is a newly available bedside test for the prediction of time to spontaneous preterm delivery via the detection of placental alpha microglobulin-1. The objective of this study was to determine the efficacy of the test in predicting imminent delivery in 7 or 14 days from the time of testing.
  
  
  METHODS
  The study population consisted of 101 consecutively recruited pregnant women with singleton pregnancies between 20+0 and 36+6 weeks of gestation with symptoms of preterm labor, clinically intact amniotic membranes, and minimal cervical dilatation (≤3 cm). The PartoSure TTD test was performed on these patients and the test-to-spontaneous-delivery interval was calculated.
  
  
  RESULTS
  The PartoSure TTD test predicted spontaneous preterm delivery within 7 days with 90.0% sensitivity, 93.8% specificity, 97.4% negative predictive value (NPV), and 78.3% positive predictive value (PPV). The test predicted spontaneous preterm delivery within 14 days with 80% sensitivity, 96.1% specificity, 93.6% NPV, and 87.0% PPV.
  
  
  CONCLUSIONS
  A positive PartoSure TTD test in patients presenting with symptoms of preterm labor, intact membranes, and minimal cervical dilatation (≤3 cm) indicated spontaneous preterm delivery will occur within 7 days with a high degree of accuracy. A negative result indicated that spontaneous preterm delivery within 14 days is highly unlikely.
authors: Tanja
authors: T
authors: Nikolova
authors: Oleg
authors: O
authors: Bayev
authors: Natasha
authors: N
authors: Nikolova
authors: Gian Carlo
authors: GC
authors: Di Renzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis*; D002584:Cervix Uteri; D005260:Female; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D047928:Premature Birth / Q000175:diagnosis*; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013997:Time Factors; D055815:Young Adult
chemical_list: D000510:Alpha-Globulins; D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; C016001:alpha-1-microglobulin