title: Kounis syndrome leads to cardiogenic shock.
abstract: Kounis syndrome has been defined as an acute coronary syndrome that manifests as unstable vasospastic or nonvasospastic angina, and even as acute myocardial infarction. It is triggered by the release of inflammatory mediators following an allergic insult or patient ill health, drug intake or environmental exposure. We report on a patient who was admitted to our hospital and diagnosed with unstable angina or acute myocardial infarction - according to analytical parameters, electrocardiographic abnormalities, and/or coronary angiography - in the context of progesterone as inducing factor. The results of a laboratory study revealed electrocardiogram changes, and increased myocardial enzymes, IgE antibodies and eosinophils. The patient experienced recurring chest pain, acute myocardial infarction, and cardiogenic shock after taking progesterone capsules; her medication history of progesterone clearly correlated with the onset of chest pain, which suggested that the cause of the vasospasm may have been related to progesterone use. We did not include patients with a history of bronchial asthma or allergic constitution. Nevertheless, the case suggests there is a correlation between Kounis syndrome and progesterone as inducing factor.
authors: Department of Cardiology, 3rd Hospital of the Chinese People's Liberation Army, 45 Dongfeng Road, Baoji, Shaanxi Province, China.
authors: Kuai-Le
authors: KL
authors: Chang
authors: Jiu
authors: J
authors: Chen
authors: Jun
authors: J
authors: Yu
authors: Xiao-Liang
authors: XL
authors: Dou
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D011374:Progesterone / Q000009:adverse effects*; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D011374:Progesterone