title: Graphene oxide doped conducting polymer nanocomposite film for electrode-tissue interface.
abstract: One of the most significant components for implantable bioelectronic devices is the interface between the microelectrodes and the tissue or cells for disease diagnosis or treatment. To make the devices work efficiently and safely in vivo, the electrode-tissue interface should not only be confined in micro scale, but also possesses excellent electrochemical characteristic, stability and biocompatibility. Considering the enhancement of many composite materials by combining graphene oxide (GO) for its multiple advantages, we dope graphene oxide into poly(3,4-ethylenedioxythiophene) (PEDOT) forming a composite film by electrochemical deposition for electrode site modification. As a consequence, not only the enlargement of efficient surface area, but also the development of impedance, charge storage capacity and charge injection limit contribute to the excellent electrochemical performance. Furthermore, the stability and biocompatibility are confirmed by numerously repeated usage test and cell proliferation and attachment examination, respectively. As electrode-tissue interface, this biomaterial opens a new gate for tissue engineering and implantable electrophysiological devices.
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Hong-Chang
authors: HC
authors: Tian
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China. Electronic address: jqliu@sjtu.edu.cn.
authors: Jing-Quan
authors: JQ
authors: Liu
authors: National Engineering Research Center for Nanotechnology, Shanghai, PR China.
authors: Dai-Xu
authors: DX
authors: Wei
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Xiao-Yang
authors: XY
authors: Kang
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Chuan
authors: C
authors: Zhang
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Jing-Cheng
authors: JC
authors: Du
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Bin
authors: B
authors: Yang
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Xiang
authors: X
authors: Chen
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Hong-Ying
authors: HY
authors: Zhu
authors: Department of Chemical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Yan-Na
authors: YN
authors: Nuli
authors: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Chun-Sheng
authors: CS
authors: Yang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites; D010087:Oxides / Q000737:chemistry*; D016716:PC12 Cells; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D011108:Polymers; D006108:Graphite
keywords: Conducting polymer; Electrochemical deposition; Electrode-tissue interface; Graphene oxide; Microelectrode; Tissue engineering