title: Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties.
abstract: Two new sesquiterpene lactones, namely feruhodin A and feruhodin B, together with six known compounds, daucoeudesmanolactone, dehydrooopodin, oopodin, badkhysin, 7-demethylplastochromenol, and scoparone, were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin possessed significant cytotoxic effects with IC₅₀ values of 15 and 5 μM against MCF7 and K562, respectively.
authors: a Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.
authors: Jamal
authors: J
authors: Kasaian
authors: Milad
authors: M
authors: Iranshahy
authors: Milena
authors: M
authors: Masullo
authors: Sonia
authors: S
authors: Piacente
authors: Fatemeh
authors: F
authors: Ebrahimi
authors: Mehrdad
authors: M
authors: Iranshahi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005309:Ferula / Q000737:chemistry*; D006801:Humans; D007492:Iran; D020014:K562 Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D007783:Lactones; D012717:Sesquiterpenes; C587269:feruhodin A; C587268:feruhodin B; C018145:scoparone