title: Effects of iron therapy on blood lead concentrations in infants.
abstract: To determine whether blood lead concentration is elevated in iron-deficient infants, blood lead and serum ferritin concentrations, serum iron/transferring iron-binding capacity (Fe/TIBC) and complete blood counts were measured in 30 iron deficient and 35 control infants, aged 6-24 months. All 30 iron-deficient infants received iron supplementation (ferric hydroxide-polymaltose complex, 6mg/kg Fe(3+)/day) for 1-6 months. Blood lead concentrations were measured in 18 of the iron deficient infants after their ferritin levels returned to the normal range. The geometric mean blood lead concentration was higher in iron deficient than in control infants (1.846 vs. 1.416μg/dL). After iron therapy, the blood lead levels of iron-deficient infants decreased significantly compared with pre-treatment levels (1.785 vs. 2.386μg/dL), and the hemoglobin and ferritin concentrations increased significantly. These findings indicate that iron deficiency increases blood lead concentrations in infants with very low blood lead concentrations.
authors: Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
authors: Sangkyu
authors: S
authors: Park
authors: Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
authors: Chang Sun
authors: CS
authors: Sim
authors: Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
authors: Heun
authors: H
authors: Lee
authors: Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. Electronic address: yanghokm@nuri.net.
authors: Yangho
authors: Y
authors: Kim
mesh_terms: D000740:Anemia / Q000097:blood / Q000188:drug therapy; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy; D001772:Blood Cell Count; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood / Q000627:therapeutic use*; D007854:Lead / Q000097:blood; D008297:Male
chemical_list: D006454:Hemoglobins; D007854:Lead; D005293:Ferritins; D007501:Iron
keywords: Anemia; Deficiency; Iron; Lead