title: Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides.
abstract: Posttraumatic stress disorder (PTSD) co-occurs highly with substance use disorders (SUDs), yet the neurobiological basis for this comorbid relationship remains unclear. PTSD and SUDs result in similar pathological states including impulsive behavior, reward deficiency, and heightened stress sensitivity. Hence, PTSD and SUD may depend on overlapping dysfunctional neurocircuitry. Here we provide a short overview of the relationship between comorbid PTSD and SUD, as well as the potential role of select neurotransmitter systems that may underlie enhanced vulnerability to drug abuse in the context of PTSD.
authors: Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: nicole.enman@temple.edu.
authors: Nicole M
authors: NM
authors: Enman
authors: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA. Electronic address: zhangyo@mail.rxockefeller.edu.
authors: Yong
authors: Y
authors: Zhang
authors: Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: ellen.unterwald@temple.edu.
authors: Ellen M
authors: EM
authors: Unterwald
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology*; D006801:Humans; D023421:Models, Animal; D009042:Motivation; D009479:Neuropeptides / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000473:pathology*; D019966:Substance-Related Disorders / Q000473:pathology*
chemical_list: D015306:Biogenic Monoamines; D009479:Neuropeptides
keywords: Addiction; Monoamines; Neuropeptides; Posttraumatic stress disorder; Substance use disorders