title: Effects of dehydroepiandrosterone sulfate on blood pressure and aldosterone level via μ-opioid receptors.
abstract: Dehydroepiandrosterone sulfate (30 mg/kg) produced a hypotensive effect by preventing stress-induced surge of hypertensive hormone aldosterone in rats after manifold repeated, but not single stress exposure. Both effects were realized via μ-opioid receptors. Thus, μ-opioid mechanism of blockage of aldosterone surge can underlay the hypotensive effects of dehydroepiandrosterone sulfate at least under conditions of manifold repeated exposures.
authors: Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. maryov@ngs.ru.
authors: T A
authors: TA
authors: Obut
authors: M V
authors: MV
authors: Ovsukova
authors: T A
authors: TA
authors: Erdinieva
authors: E T
authors: ET
authors: Obut
authors: T Yu
authors: TY
authors: Dement'eva
authors: S A
authors: SA
authors: Egorova
authors: V A
authors: VA
authors: Kozlov
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D017450:Receptors, Opioid, mu; D000450:Aldosterone; D019314:Dehydroepiandrosterone Sulfate