title: Pathogenic memory type Th2 cells in allergic inflammation.
abstract: Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as 'pathogenic memory Th cells.' Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.
authors: Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors: Yusuke
authors: Y
authors: Endo
authors: Department of Advanced Allergology of the Airway, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors: Kiyoshi
authors: K
authors: Hirahara
authors: Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors: Ryoji
authors: R
authors: Yagi
authors: Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors: Damon J
authors: DJ
authors: Tumes
authors: Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; Japan Science and Technology Agency (JST), CREST, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: tnakayama@faculty.chiba-u.jp.
authors: Toshinori
authors: T
authors: Nakayama
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D003872:Dermatitis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D020381:Interleukin-17 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D051379:Mice; D018448:Models, Immunological; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D015848:Interleukin-5
keywords: IL-5; ILC2; asthma; memory Th2 diversity; pathogenic T cells