title: Radiotherapy for early-stage primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.
abstract: BACKGROUND
  Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy.
  
  
  METHODS
  From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years.
  
  
  RESULTS
  All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy.
  
  
  CONCLUSIONS
  Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. nakam@radiol.med.kyushu-u.ac.jp.
authors: Saiji
authors: S
authors: Ohga
authors: Katsumasa
authors: K
authors: Nakamura
authors: Yoshiyuki
authors: Y
authors: Shioyama
authors: Tomonari
authors: T
authors: Sasaki
authors: Tadamasa
authors: T
authors: Yoshitake
authors: Kazushige
authors: K
authors: Atsumi
authors: Kotaro
authors: K
authors: Terashima
authors: Kaori
authors: K
authors: Asai
authors: Keiji
authors: K
authors: Matsumoto
authors: Hiroshi
authors: H
authors: Yoshikawa
authors: Yo-Ichi
authors: Y
authors: Kawano
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D055815:Young Adult
keywords: MALT lymphoma; Radiotherapy; ocular adnexal