title: Two novel anti-inflammatory 21-nordammarane saponins from tetraploid Jiaogulan ( Gynostemma pentaphyllum ).
abstract: Two novel 20-oxo-21-nordammar-22, 24-diene saponins, 21-norgypenosides A (1) and B (2), were characterized from the aerial parts of tetraploid Jiaogulan ( Gynostemma pentaphyllum ), a popular tea ingredient. Their structures, including the absolute configurations, were comprehensively elucidated by HRESIMS, 1D and 2D NMR data, chemical degradation, and through comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. The two compounds suppressed the expression of interleukin (IL)-1β, cyclooxygenase (COX)-2, and tumor necrosis factor (TNF)-α mRNAs in the lipopolysaccharide-induced RAW 264.7 mouse macrophage cells at 10 and 100 μg/mL, suggesting their potential anti-inflammatory effects.
authors: Institute of Food and Nutraceutical Science, SJTU-Rich Research Institute, School of Agriculture and Biology, Shanghai Jiao Tong University , Shanghai 200240, China.
authors: Fei
authors: F
authors: Yang
authors: Haiming
authors: H
authors: Shi
authors: Xiaowei
authors: X
authors: Zhang
authors: Liangli Lucy
authors: LL
authors: Yu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D029774:Gynostemma / Q000737:chemistry* / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D057891:Tetraploidy; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D010936:Plant Extracts; D012503:Saponins; D014409:Tumor Necrosis Factor-alpha