title: Noninvasive Measurements of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen using Magnetic Resonance Imaging.
abstract: Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expected physiological changes in humans under normal and hyperoxic hypercapnic conditions. Nine healthy human subjects were scanned while breathing through a mask, alternating inhaled gas in a sequential order as room air, carbogen (3% CO2 mixed with 97% O2), room air, carbogen, and room air. OEF, CBF, and OMI were obtained from the whole brain, gray matter (GM), and white matter (WM) at each gas inhalation state. Similar to previous positron emission tomography findings, our study consistently demonstrated a 10-12% decrease in OEF with a 10% increase of CBF and a stable OMI during carbogen inhalation. Moreover, GM/WM ratio in CBF and OMI remained constant during air and carbogen breathing. In addition, OEF, CBF, and OMI were highly reproducible if the same inhaled gas was used. In summary, our results demonstrate that noninvasive MR measurements can provide reproducible measurements of OEF, CBF, and OMI in normal subjects under normal and altered physiological conditions.
authors: Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, CB#7513, Chapel Hill, NC, 27599, USA, hongyuan@med.unc.edu.
authors: Hongyu
authors: H
authors: An
authors: Souvik
authors: S
authors: Sen
authors: Yasheng
authors: Y
authors: Chen
authors: William J
authors: WJ
authors: Powers
authors: Weili
authors: W
authors: Lin