title: In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts.
abstract: Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress in mitochondrial division by focusing on molecular and in vivo analyses of the evolutionarily conserved, central component of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms.
authors: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: hsesaki@jhmi.edu.
authors: Hiromi
authors: H
authors: Sesaki
authors: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Yoshihiro
authors: Y
authors: Adachi
authors: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Yusuke
authors: Y
authors: Kageyama
authors: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Kie
authors: K
authors: Itoh
authors: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Miho
authors: M
authors: Iijima
mesh_terms: D000818:Animals; D034281:Dynamins / Q000378:metabolism*; D055786:Gene Knockout Techniques; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D034281:Dynamins
keywords: Dynamin-related GTPase; Membrane fission; Mitochondrion; Mouse; Neurodegeneration; Yeast