title: Age-adjusted glycated albumin: a more robust parameter to establish glycaemic control in neonatal diabetes mellitus.
abstract: BACKGROUND
  We previously reported that glycated albumin (GA) levels increased in an age-dependent manner in infancy. In order to determine whether this phenomenon is true from infancy to adulthood, we investigated the GA levels in non-diabetic subjects of a wide range of age.
  
  
  METHODS
  GA levels of 376 non-diabetic subjects [average age, 31.8 ± 23.8 years (4 days-78 years)] were determined. A relationship between GA and logarithmically transformed age [log(age)] was analysed.
  
  
  RESULTS
  GA levels were significantly positively correlated with log(age) [R = 0.865, P < 0.0001, GA = 1.77 × log(day) + 6.55]. Based on a regression line, we established the formula for adjusting GA levels according to age.
  
  
  CONCLUSIONS
  We showed that GA increases with age from infancy to adulthood and that normal GA levels are demonstrated as a simple regression formula with log(age). This formula allowing us to use the adult reference range has the potential for treatment monitoring of diabetic patients regardless of age.
authors: Department of Pediatrics, Asahikawa Medical University, Japan shige5p@asahikawa-med.ac.jp.
authors: Shigeru
authors: S
authors: Suzuki
authors: Department of Internal Medicine, Kawanishi City Hospital, Japan.
authors: Masafumi
authors: M
authors: Koga
authors: Department of Medical Laboratory and Blood Center, Asahikawa Medical University Hospital, Japan.
authors: Noriyasu
authors: N
authors: Niizeki
authors: Department of Pediatrics, Asahikawa Medical University, Japan.
authors: Akiko
authors: A
authors: Furuya
authors: Department of Pediatrics, Asahikawa Medical University, Japan.
authors: Kumihiro
authors: K
authors: Matsuo
authors: Department of Pediatrics, Asahikawa Medical University, Japan.
authors: Yusuke
authors: Y
authors: Tanahashi
authors: Department of Pediatrics, Asahikawa Medical University, Japan.
authors: Hiroshi
authors: H
authors: Azuma
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis; D012709:Serum Albumin / Q000032:analysis*; D055815:Young Adult; D000093423:Glycated Serum Albumin
chemical_list: D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Neonatal diabetes mellitus; glycaemic control; glycated albumin