title: Association study between SNP rs150689919 in the DNA demethylation gene, TET1, and Parkinson's disease in Chinese Han population.
abstract: BACKGROUND
  Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson's disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedigrees were found sharing the variant c.1460C > T (rs150689919) in the coding region of the Tet methyl cytosine dioxygenase 1 (TET1) gene.
  
  
  METHODS
  In order to evaluate the possible association between sporadic PD and the single nucleotide polymorphism (SNP) rs150689919 in TET1, a case-control cohort study was conducted in 514 sporadic PD patients and 529 normal controls. Genotyping was determined by PCR and direct sequencing. Statistical significance was analyzed by the Chi-squared test.
  
  
  RESULTS
  There was no statistical significance in TET1 rs150689919 genotype or allele frequencies between the PD cases and healthy controls, even after being stratified by gender and age at onset.
  
  
  CONCLUSIONS
  Our findings suggest that rs150689919 in TET1 may not be associated with PD in Chinese population. However, due to the limited data in this study, replication studies in larger sample and other populations are required.
authors: Xin-xin
authors: XX
authors: Liao
authors: Zi-xiong
authors: ZX
authors: Zhan
authors: Ying-ying
authors: YY
authors: Luo
authors: Kai
authors: K
authors: Li
authors: Jun-ling
authors: JL
authors: Wang
authors: Ji-feng
authors: JF
authors: Guo
authors: Xin-xiang
authors: XX
authors: Yan
authors: Kun
authors: K
authors: Xia
authors: Bei-sha
authors: BS
authors: Tang
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P, R, China. shenlu2505@126.com.
authors: Lu
authors: L
authors: Shen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D016009:Chi-Square Distribution; D002648:Child; D019175:DNA Methylation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human