title: Efficient photosensitization by a chlorin-polyoxometalate supramolecular complex.
abstract: The 4:1 supramolecular complexed ionic salt between pyridinium chlorin and polyanionic [α-SiMo12O40](4-) exhibits significantly enhanced photodynamic activity against A549 cell lines because of increased singlet oxygen photogeneration through high cellular penetration and localization of the chlorin molecules on the ionic salt into the cancer cell. Confocal laser scanning microscopy images clearly represent a higher uptake and photodynamic effect of this supramolecular complex corresponding to the lower IC50 value compared to the free chlorin.
authors: PDT Research Institute, School of Nano System Engineering, Inje University , 197 Injero, Gimhae, Gyeongnam 621-749, Republic of Korea.
authors: Il
authors: I
authors: Yoon
authors: Jung Hwa
authors: JH
authors: Kim
authors: Jia Zhu
authors: JZ
authors: Li
authors: Woo Kyoung
authors: WK
authors: Lee
authors: Young Key
authors: YK
authors: Shim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D017973:Tungsten Compounds / Q000737:chemistry / Q000494:pharmacology*; D000099294:Polyoxometalates
chemical_list: D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D017319:Photosensitizing Agents; D011166:Porphyrins; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates; C006969:chlorin