title: The long-term effects of splenectomy and subsequent interferon therapy in patients with HCV-related liver cirrhosis.
abstract: Partial splenic embolization (PSE) or splenectomy is widely performed to increase platelet counts for interferon (IFN) therapy. The aim of the present study was to evaluate the long-term effects of splenectomy and subsequent IFN therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The present study included 19 patients with HCV-related LC who underwent splenectomy for thrombo-cytopenia caused by hypersplenism. IFN therapy was performed in all 19 patients. The effects of splenectomy and subsequent IFN therapy on peripheral blood counts, liver function, carcinogenesis and survival rates were evaluated. Splenectomy was safely performed in all patients without major complications with the exception of portal thrombosis, which, however, it did not affect liver function when treated appropriately. Thrombocytopenia improved and IFN therapy could be performed in all the patients. A sustained virological response (SVR) was not observed in patients with genotype 1 although it was observed in 75% of patients with genotype 2. Due to severe side effects, five patients did not undergo scheduled IFN therapy. Over 5 years, the mean platelet number increased from 5.2 x 10(4) to 16.8 x 10(4)/mm3 (P<0.01) and liver function improved following splenectomy (albumin, Alb: 3.5‑3.8 g/dl; total bilirubin, T-Bil: 1.0‑0.7 mg/dl; prothrombin time, PT: 74.1‑97.7%; total cholesterol; T-cho: 140‑168 mg/dl; P<0.05). Hepatocellular carcinoma (HCC) occurred in only one patient during long‑term observation and follow‑up of the patients not presenting with HCC at entry. The results of the present study demonstrate that splenectomy followed by interferon therapy could be beneficial in patients with HCV-related LC.
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Yuji
authors: Y
authors: Inagaki
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Kazushi
authors: K
authors: Sugimoto
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Katsuya
authors: K
authors: Shiraki
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Masahiko
authors: M
authors: Tameda
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Satoko
authors: S
authors: Kusagawa
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Keiichiro
authors: K
authors: Nojiri
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Suguru
authors: S
authors: Ogura
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Norihiko
authors: N
authors: Yamamoto
authors: Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Yoshiyuki
authors: Y
authors: Takei
authors: Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Masaaki
authors: M
authors: Ito
authors: Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Shugo
authors: S
authors: Mizuno
authors: Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Masanobu
authors: M
authors: Usui
authors: Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Hiroyuki
authors: H
authors: Sakurai
authors: Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors: Shuji
authors: S
authors: Isaji
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000601:surgery; D013156:Splenectomy
chemical_list: D007372:Interferons