title: Salivary markers of oxidative stress in patients with obstructive sleep apnea treated with continuous positive airway pressure.
abstract: OBJECTIVE
  Obstructive sleep apnea syndrome (OSAS) is characterized by elevated oxidative stress. Measurement of oxidative stress in saliva seems to be promising in long-term treatment monitoring of OSAS patients. In this study, our aim was to investigate whether short-term continuous positive airway pressure (CPAP) treatment would influence oxidative stress in saliva.
  
  
  METHODS
  Patients with diagnosed OSAS (16 women, 28 men) underwent polysomnography during the first night and CPAP treatment during the second night. Saliva samples were taken in the evening and morning on both days. Markers of oxidative stress and antioxidant status were analyzed in saliva.
  
  
  RESULTS
  Evening concentrations of the salivary thiobarbituric acid reacting substances (p < 0.001), advanced glycation end-products (p < 0.001), and advanced oxidation protein products (p < 0.01) were significantly lower than morning values during the diagnostic night. However, salivary concentrations of none of the oxidative stress markers were significantly influenced by the CPAP treatment. No changes in salivary antioxidant status after CPAP therapy were found.
  
  
  CONCLUSIONS
  Salivary markers of oxidative stress and antioxidant status do not change significantly after one night treatment with CPAP. On the contrary, after 1 month with CPAP therapy, reduced markers of oxidative stress were reported. Therefore, the future studies should be focused on finding the optimal sampling frequency to clarify the potential of saliva for the monitoring of OSAS treatment.
authors: Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovak Republic.
authors: L'ubomíra
authors: L
authors: Tóthová
authors: Július
authors: J
authors: Hodosy
authors: Imrich
authors: I
authors: Mucska
authors: Peter
authors: P
authors: Celec
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D045422:Continuous Positive Airway Pressure; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017286:Polysomnography; D012016:Reference Values; D012463:Saliva / Q000737:chemistry*; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D017127:Glycation End Products, Advanced; D017392:Thiobarbituric Acid Reactive Substances