title: Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgaris.
abstract: Psoriasis vulgaris (PV) is a chronic inflammatory and T cell-mediated autoimmune skin disease. An immune dysfunction that is manifested by abnormally activated T cells and defective regulatory T (Treg) cells may play an important role in the pathogenesis of PV. However, the precise mechanism of the immune dysfunction in PV patients still remains unclear. In this study, we found that miR-210 expression is increased significantly in CD4(+) T cells from patients with PV and confirmed that FOXP3 is a target gene of miR-210. We also found that overexpression of miR-210 inhibits FOXP3 expression and impairs the immunosuppressive functions of Treg cells in CD4(+) T cells from healthy controls. In contrast, inhibition of miR-210 increases FOXP3 expression and reverses the immune dysfunction in CD4(+) T cells from patients with PV. Our data demonstrates that increased miR-210 induces immune dysfunction via by FOXP3 in CD4(+) T cells from patients with PV.
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Ming
authors: M
authors: Zhao
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Li-tao
authors: LT
authors: Wang
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Gong-ping
authors: GP
authors: Liang
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Peng
authors: P
authors: Zhang
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Xin-jie
authors: XJ
authors: Deng
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Qian
authors: Q
authors: Tang
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China.
authors: Han-yue
authors: HY
authors: Zhai
authors: Division of Allergy, Asthma and Immunology, Department of Pediatrics, Thomas Jefferson University Hospital, USA.
authors: Christopher C
authors: CC
authors: Chang
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China. Electronic address: suyuwen@medmail.com.cn.
authors: Yu-wen
authors: YW
authors: Su
authors: Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China. Electronic address: qianlu5860@gmail.com.
authors: Qian-jin
authors: QJ
authors: Lu
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000235:genetics; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C543800:MIRN210 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger
keywords: CD4(+) T cells; FOXP3; MicroRNA; Psoriasis vulgaris; Treg cells; miR-210