title: In Vitro activity of fosfomycin against Escherichia coli isolated from patients with urinary tract infections in Canada as part of the CANWARD surveillance study.
abstract: We tested 868 urinary isolates of Escherichia coli collected from 2010 to 2013 as part of the Canadian national surveillance study CANWARD against fosfomycin by using the Clinical and Laboratory Standards Institute (CLSI) agar dilution method with MIC interpretation in accordance with the CLSI M100-S23 (2013) criteria. The concentrations of fosfomycin inhibiting 50 and 90% of the isolates were ≤1 and 4 μg/ml; 99.4% of the isolates were susceptible to fosfomycin.
authors: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada.
authors: James A
authors: JA
authors: Karlowsky
authors: Andrew J
authors: AJ
authors: Denisuik
authors: Philippe R S
authors: PR
authors: Lagacé-Wiens
authors: Heather J
authors: HJ
authors: Adam
authors: Melanie R
authors: MR
authors: Baxter
authors: Daryl J
authors: DJ
authors: Hoban
authors: George G
authors: GG
authors: Zhanel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002170:Canada; D024881:Drug Resistance, Bacterial; D062665:Epidemiological Monitoring; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D005578:Fosfomycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin