title: One-step nucleotide-programmed growth of porous upconversion nanoparticles: application to cell labeling and drug delivery.
abstract: A simple and "green" strategy has been reported for the first time to fabricate upconversion nanoparticles (UCNPs) by utilizing nucleotides as bio-templates. The influence of the functionalities present on the nucleotide on the production of nanoparticles was investigated in detail. Through the effects of nucleotides, the obtained nanoparticles possessed a porous structure. The use of the as-prepared UCNPs for cell imaging, drug delivery and versatile therapy applications were demonstrated. In view of the bright up-conversion luminescence as well as the excellent biocompatibility, and the good colloidal stability of the as-prepared UCNPs, we envision that our synthesis protocol might advance both the fields of UCNPs and biomolecule-based nanotechnology for future studies.
authors: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors: Li
authors: L
authors: Zhou
authors: Zhenhua
authors: Z
authors: Li
authors: Zhen
authors: Z
authors: Liu
authors: Meili
authors: M
authors: Yin
authors: Jinsong
authors: J
authors: Ren
authors: Xiaogang
authors: X
authors: Qu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers; D055772:Green Chemistry Technology; D006801:Humans; D049449:Luminescence; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009711:Nucleotides / Q000737:chemistry*; D010778:Photochemotherapy; D016062:Porosity; D026082:Singlet Oxygen / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003102:Colloids; D004337:Drug Carriers; D009711:Nucleotides; D012997:Solvents; D026082:Singlet Oxygen