title: Evaluation of patients with head and neck cancer performing standard treatment in relation to body composition, resting metabolic rate, and inflammatory cytokines.
abstract: BACKGROUND
  Squamous cell carcinoma of the head and neck (SCCHN) usually emerges as a set of signs and symptoms that, either alone or in combination with standard treatment, may lead to malnutrition and weight loss.
  
  
  METHODS
  This study evaluated patients with SCCHN before day 0 and 30 days after the end of treatment, with/without tumor resection. Each individual patient underwent analyses of body composition and resting metabolic rate, as well as assessment of serum glucose, insulin, leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1β, and insulin sensitivity.
  
  
  RESULTS
  There was body mass loss during treatment and significant reduction in body fat and free fat mass. Early nutritional monitoring and tumor resection before treatment led to a better nutritional status and reduced inflammatory state.
  
  
  CONCLUSIONS
  Early nutritional monitoring and resection of the tumor by surgery may be important factors for patients to better tolerate treatment.
authors: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, São Paulo, Brazil.
authors: Thalyta Morandi Ridolfi
authors: TM
authors: de Carvalho
authors: Daniela
authors: D
authors: Miguel Marin
authors: Conceição Aparecida
authors: CA
authors: da Silva
authors: Aglécio Luiz
authors: AL
authors: de Souza
authors: Maristela
authors: M
authors: Talamoni
authors: Carmen Silvia Passos
authors: CS
authors: Lima
authors: Sarah
authors: S
authors: Monte Alegre
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D059248:Chemoradiotherapy; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D006304:Health Status; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D000077195:Squamous Cell Carcinoma of Head and Neck; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D053583:Interleukin-1beta; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha
keywords: cachexia; cancer; head and neck; indirect calorimetry; metabolism