title: [Association study of PRDM16 gene polymorphisms with essential hypertension in Xinjiang Uygur population].
abstract: OBJECTIVE
  To assess the association of polymorphisms of PR domain containing 16 gene (PRDM16) with essential hypertension in ethnic Uygur population from Xinjiang, China.
  
  
  METHODS
  Functional regions of the PRDM16 gene were sequenced in 48 Uygur subjects with essential hypertension selected from 480 hypertensive patients and 819 normotensive controls. Representative variations were genotyped with TaqMan-PCR method. Association of variations of PRDM16 gene with hypertension was analyzed.
  
  
  RESULTS
  For the 4 genotyped representative variations (rs2236518, rs2282198, rs2493292 and rs870171), no significant difference in genotype distribution and allele frequencies has been found between the patient and control groups (P>0.05). By ANOVA analysis, none of the polymorphisms was significantly associated with systolic or diastolic blood pressure (P>0.05). Nor was significant difference in haplotypic frequencies between the two groups detected (P>0.05).
  
  
  CONCLUSIONS
  We have found no association between the four polymorphisms (rs2236518, rs2282198, rs2493292 and rs870171) of the PRDM16 gene with essential hypertension in ethnic Uygur population from Xinjiang.
authors: Hypertension Department of People's Hospital of Xinjiang Uygur Autonomous Region, Center of Diagnosis, Treatment and Research of Hypertension, Urumqi, Xinjiang 830001, P.R. China. lnanfang2010@sina.com.
authors: Nan-fang
authors: NF
authors: Li
authors: Hong-mei
authors: HM
authors: Wang
authors: Yun-wei
authors: YW
authors: Bi
authors: Ling
authors: L
authors: Zhou
authors: Xiao-guang
authors: XG
authors: Yao
authors: Zhi-tao
authors: ZT
authors: Yan
authors: Fei-ya
authors: FY
authors: Zu
mesh_terms: D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C416371:PRDM16 protein, human; D014157:Transcription Factors