title: Does lean tissue mass accrual during adolescence influence bone structural strength at the proximal femur in young adulthood?
abstract: The purpose of this study was to identify whether young adult bone structural strength at the hip is associated with adolescent lean tissue mass (LTM) accrual. It was observed that those individuals who accrued more LTM from adolescence to adulthood had significantly greater adult bone structural strength at the hip.
  
  
  BACKGROUND
  The purpose of this study was to identify whether young adult bone cross-sectional area (CSA), section modulus (Z), and outer diameter (OD) at the hip were associated with adolescent LTM accrual.
  
  
  METHODS
  One hundred three young adult participants (55 males, 48 females) were tertiled into adolescent LTM accrual groupings. LTM accrual was assessed by serial measures using dual energy X-ray absorptiometry (DXA) from adolescence to young adulthood (21.3 ± 1.3 years). CSA, Z, and OD at the narrow neck (NN) and femoral shaft (S) sites of the proximal femur were assessed in young adulthood (21.3 ± 4.5 years), using hip structural analysis. Group differences were assessed using an analysis of covariance, controlling for adult height, weight, sex, and physical activity levels.
  
  
  RESULTS
  It was found that individuals with higher adjusted adolescent LTM accrual had significantly greater adult adjusted values of NNCSA (2.49 ± 0.06 vs 2.77 ± 0.07 cm(2)), NN Z (1.18 ± 0.04 vs 1.37 ± 0.04 cm(3)), NN OD (3.07 ± 0.04 vs 3.21 ± 0.04 cm), SCSA (3.45 ± 0.08 vs 3.88 ± 0.09 cm(3)), and SZ (1.77 ± 0.05 vs 2.00 ± 0.05 cm(3)) than individuals with lower LTM accrual (p < 0.05).
  
  
  CONCLUSIONS
  These findings suggest that the amount of LTM accrued from adolescence to young adulthood has a positive influence on adult bone structural strength at the proximal femur.
authors: College of Kinesiology, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK, Canada, stefan.jackowski@usask.ca.
authors: S A
authors: SA
authors: Jackowski
authors: J L
authors: JL
authors: Lanovaz
authors: C
authors: C
authors: Van Oort
authors: A D G
authors: AD
authors: Baxter-Jones
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000293:Adolescent; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000886:Anthropometry / Q000379:methods; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000502:physiology*; D005272:Femur Neck / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity / Q000502:physiology