title: Simultaneous sonication assistance for the synthesis of tetrahydropyridines and its efficient catalyst ZrP2O7 nanoparticles.
abstract: In this research, a general synthetic method for the synthesis of tetrahydropyridines were developed using ZrP2O7 nanoparticles under ultrasonic irradiations. Firstly by a simple and green process, nano zirconium pyrophosphate was prepared via sonication. Subsequently, this nanoparticle was used as an efficient catalyst for the synthesis of highly functionalized tetrahydropyridines via five-component reaction of aromatic aldehyde, amine and ethyl acetoacetate in ethanol under ultrasound irradiation. The present approach offers several advantages such as high yields, environmentally benign, simple work-up, excellent yield of products, short reaction times as well as recoverability and reusability of the catalyst.
authors: Chemistry Department, Imam Hossein University, P.O. Box 16575-347, Tehran, Iran. Electronic address: Ajavidan@ihu.ac.ir.
authors: Abdollah
authors: A
authors: Javidan
authors: Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, Iran.
authors: Abolfazl
authors: A
authors: Ziarati
authors: Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, Iran. Electronic address: safaei@kashanu.ac.ir.
authors: Javad
authors: J
authors: Safaei-Ghomi
keywords: Green chemistry; Multicomponent reactions; Tetrahydropyridines; Ultrasonic irradiation; ZrP(2)O(7) nanoparticles