title: A functional polymorphism in MIR196A2 is associated with risk and progression of nasopharyngeal carcinoma in the Chinese population.
abstract: BACKGROUND
  Genetic variations in microRNAs may alter their processing, expression, and binding to target mRNAs, consequently affecting many cancer-related biological processes. Recently, a polymorphism rs11614913 in MIR196A2 was shown to affect the processing of the precursor microRNA into its mature forms and the repertoire of target mRNAs with which it interacts. We examined whether this polymorphism was relevant to the risk of occurrence or progression of nasopharyngeal carcinoma (NPC) in the Chinese population.
  
  
  METHODS
  We genotyped the MIR196A2 rs11614913 in a case-control study of 1084 patients with NPC and 1036 cancer-free controls using the TaqMan assay. The genetic associations with the risk of occurrence and progression of NPC were analyzed by logistic regression.
  
  
  RESULTS
  We observed a significantly increased occurrence of NPC associated with the rs11614913 T allele (odds ratio [OR]=1.15, 95% confidence interval [CI]=1.02-1.32, p=0.026) compared with the C allele. The T allele was also significantly associated with the advanced local tumor invasion (T₃+T₄ vs. T₁+T₂; OR=1.27, 95% CI=1.04-1.54, p=0.015) and advanced lymph node metastasis (N₂+N₃ vs. N₀+N₁; OR=1.23, 95% CI=1.02-1.49, p=0.031) of NPC compared with the C allele. Furthermore, stratified analysis indicated that the increased susceptibility to advanced lymph node metastasis of NPC related to the T allele was more pronounced in patients with a positive family history (N₂+N₃ vs. N₀+N₁; p=0.016, test for homogeneity).
  
  
  CONCLUSIONS
  Our study suggests that the functional polymorphism rs11614913 in the MIR196A2 gene may contribute to the risk of occurrence and progression of NPC in the Chinese population.
authors: 1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , Beijing, People's Republic of China .
authors: Peiyao
authors: P
authors: Li
authors: Hongbo
authors: H
authors: Yan
authors: Hongxing
authors: H
authors: Zhang
authors: Lixia
authors: L
authors: Yu
authors: Zhifu
authors: Z
authors: Wang
authors: Yun
authors: Y
authors: Zhai
authors: Xia
authors: X
authors: Xia
authors: Jiye
authors: J
authors: Zhang
authors: Yang
authors: Y
authors: Zhang
authors: Fuchao
authors: F
authors: Ma
authors: Wenfeng
authors: W
authors: Huang
authors: Mi
authors: M
authors: Cai
authors: Ying
authors: Y
authors: Cui
authors: Fuchu
authors: F
authors: He
authors: Gangqiao
authors: G
authors: Zhou
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002277:Carcinoma; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs