title: [Premature immunosenescence in triple-transgenic mice for Alzheimer's disease].
abstract: BACKGROUND
  A deterioration of the neuroimmunoendocrine network has been observed in Alzheimer's disease (AD). However, the peripheral immune response has hardly been investigated in this pathology. Since some immune function parameters have been established as good markers of the rate of ageing, and can predict longevity, the aim of the present work was to study some of these functions in splenic leucocytes in transgenic mice for AD of different ages.
  
  
  METHODS
  Young female (4 ± 1 months), adult (9 ± 1 months), and mature (12 ± 1 months) triple-transgenic mice for AD (3 xTgAD) and non-transgenic (NTg) control mice of the same ages were used. The chemotaxis, the anti-tumour activity of « natural killer » (NK) cells and the lymphoproliferative response in the presence of the mitogens concanavalin A and lipopolysaccharide, functions that decrease with age, were determined in splenic leucocytes. In addition, the differences in lifespan between 3 xTgAD and NTg were studied in parallel using other animals, until their death through natural causes.
  
  
  RESULTS
  In 3 xTgAD, with respect to NTg, chemotaxis decreased at all ages studied, whereas in lymphoproliferative response this reduction was shown at 4 months and 9 months. NK activity was diminished only in young 3 xTgAD with respect to NTg. The 3 xTgAD showed a shorter lifespan than the NTg control group.
  
  
  CONCLUSIONS
  The 3 xTgAD mice show a premature immunosenescence, which could explain their early mortality. The determination of these immune functions at peripheral level could serve as a marker of the progression of the Alzheimer's disease.
authors: Departamento de Fisiología, Facultad de Biología, Universidad Complutense de Madrid, Madrid, España.
authors: Ianire
authors: I
authors: Mate
authors: Departamento de Fisiología, Facultad de Biología, Universidad Complutense de Madrid, Madrid, España.
authors: Julia
authors: J
authors: Cruces
authors: Departamento de Fisiología, Facultad de Biología, Universidad Complutense de Madrid, Madrid, España.
authors: Carmen
authors: C
authors: Vida
authors: Instituto de Investigación Biomédica de Barcelona, Consejo Superior de Investigaciones Científicas, Barcelona, España.
authors: Coral
authors: C
authors: Sanfeliu
authors: Departamento de Fisiología, Facultad de Biología, Universidad Complutense de Madrid, Madrid, España.
authors: Rashed
authors: R
authors: Manassra
authors: Instituto de Neurociencia, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, España.
authors: Lydia
authors: L
authors: Giménez-Llort
authors: Departamento de Fisiología, Facultad de Biología, Universidad Complutense de Madrid, Madrid, España. Electronic address: mondelaf@bio.ucm.es.
authors: Mónica
authors: M
authors: De la Fuente
mesh_terms: D000375:Aging / Q000276:immunology*; D019588:Aging, Premature / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic
keywords: Alzheimer; Immunosenescence; Inmunosenescencia; Leucocitos esplénicos; Ratones triple-transgénicos para la enfermedad de Alzheimer; Splenic leucocytes; Triple-transgenic mice for Alzheimer's disease