title: Lower incidence of M2/ANXA5 carriage in recurrent pregnancy loss patients with elevated lipoprotein(a) levels.
abstract: This study compared the incidence of M2/ANXA5 haplotype carriage, a documented repeated miscarriage risk factor, in patient groups with normal and elevated lipoprotein(a) (Lp(a)) levels. A total of 138 women with ≥2 consecutive, idiopathic recurrent miscarriages, categorized in patients with elevated (≥30 mg/dL, n = 44) and normal Lp(a) level (<30 mg/dL, n = 94) were recruited at the recurrent pregnancy loss (RPL) clinic of Munich Großhadern University Hospital. A total of 500 fertile women served as controls. All patients were genotyped for ANXA5 promoter haplotypes, genetic frequencies were compared, and odds ratios (ORs) and relative risks of M2 carriers were calculated. Women with M2 haplotype had an almost 2 times higher relative risk of RPL (OR 2.6, 95% confidence interval 1.5-4.6, P = .001) than fertile controls. Furthermore, risk rises to 2.47 in patients having normal Lp(a) levels (OR 3.2, 95% confidence interval 1.7-5.9, P = .001), whereas women with high Lp(a) levels exhibit notably lower apparent RPL risk of 1.39 (OR 1.4, 95% confidence interval 0.5-4.1, P = .659).
authors: Department of Gynecology and Obstetrics, Division of Gynecological Endocrinology and Reproductive Medicine, Klinikum der Ludwig-Maximilians-University, Munich, Germany.
authors: Nina
authors: N
authors: Rogenhofer
authors: Department of Gynecology and Obstetrics, Division of Gynecological Endocrinology and Reproductive Medicine, Klinikum der Ludwig-Maximilians-University, Munich, Germany.
authors: Laura
authors: L
authors: Engels
authors: Insititute of Human Genetics, UKM and WWU Muenster, Muenster, Germany.
authors: Nadja
authors: N
authors: Bogdanova
authors: Insititute of Human Genetics, UKM and WWU Muenster, Muenster, Germany.
authors: Frank
authors: F
authors: Tüttelmann
authors: Department of Gynecology and Obstetrics, Division of Gynecological Endocrinology and Reproductive Medicine, Klinikum der Ludwig-Maximilians-University, Munich, Germany.
authors: Christian J
authors: CJ
authors: Thaler
authors: Institute of Medical Biochemistry, ZMBE and IZKF, WWU Muenster, Muenster, Germany markoff@uni-muenster.de.
authors: Arseni
authors: A
authors: Markoff
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D017304:Annexin A5 / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D017270:Lipoprotein(a) / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D017304:Annexin A5; D017270:Lipoprotein(a)
keywords: M2/ANXA5; annexin A5; lipoprotein(a); recurrent miscarriage; recurrent pregnancy loss