title: MurA as a primary target of tulipalin B and 6-tuliposide B.
abstract: (-)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.
authors: Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University.
authors: Kengo
authors: K
authors: Shigetomi
authors: Sanne Harder
authors: SH
authors: Olesen
authors: Yan
authors: Y
authors: Yang
authors: Shinya
authors: S
authors: Mitsuhashi
authors: Ernst
authors: E
authors: Schönbrunn
authors: Makoto
authors: M
authors: Ubukata
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000494:pharmacology*
chemical_list: C551332:6-tuliposide B; D004791:Enzyme Inhibitors; D005960:Glucosides; D006885:Hydroxybutyrates; C048810:tulipalin B; D019883:Alkyl and Aryl Transferases; C022566:UDP-N-acetylglucosamine 1-carboxyvinyltransferase; D015107:4-Butyrolactone