title: Bayesian latent-class mixed-effect hybrid models for dyadic longitudinal data with non-ignorable dropouts.
abstract: The analysis of longitudinal dyadic data is challenging due to the complicated correlations within and between dyads, as well as possibly non-ignorable dropouts. Based on a mixed-effects hybrid model, we propose an approach to analyze longitudinal dyadic data with non-ignorable dropouts. We factorize the joint distribution of the measurement and dropout processes into three components: the marginal distribution of random effects, the conditional distribution of the dropout process given the random effects, and the conditional distribution of the measurement process given the random effects and missing data patterns. We model the conditional dropout process using a discrete survival model, and the conditional measurement process using a latent-class pattern-mixture model. These models account for the dyadic interdependence using the "actor" and "partner" effects and dyad-specific random effects. We use the latent-dropout-class approach to address the problem of a large number of missing data patterns caused by the dyadic data structure. We evaluate the performance of the proposed method using a simulation study, and apply our method to a longitudinal dyadic data set that arose from a prostate cancer trial.
authors: Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, U.S.A.; Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, U.S.A.
authors: Jaeil
authors: J
authors: Ahn
authors: Suyu
authors: S
authors: Liu
authors: Wenyi
authors: W
authors: Wang
authors: Ying
authors: Y
authors: Yuan
mesh_terms: D001499:Bayes Theorem; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D007172:Erectile Dysfunction / Q000453:epidemiology* / Q000534:rehabilitation*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010352:Patient Dropouts / Q000706:statistics & numerical data*; D010363:Pattern Recognition, Automated / Q000379:methods; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000534:rehabilitation*; D018401:Sample Size
keywords: Dyadic; Latent class; Longitudinal; Mixed-effect; Non-ignorable missingness