title: Depo-provera effects on Wistar rat performance in the Y-maze.
abstract: Medroxyprogesterone acetate is the most commonly used progestin component of hormone therapy. The goal of the present study was to determine whether Medroxyprogesterone affects rat behavior using a Y-maze test. Twenty-four female Wistar rats were randomly selected into three groups; control group, a low dose (13 mg/ml MPA) group and a high dose (33 mg/1 ml MPA) group. Doses of Medroxyprogesterone were delivered by intramuscular injection for a period of 3 weeks. Medroxyprogesterone administration resulted in a decrease in memory and locomotion activity of rats (p < 0.05). Despite Medroxyprogesterone being effective in modulating hormonal interaction to prevent conception in actively reproducing females, cognitive impairment could be one of its adverse effects.
authors: Department of Physiology, University of Nigeria, Enugu Campus, Enugu, Nigeria, pintos4live@yahoo.com.
authors: A K
authors: AK
authors: Okojie
authors: O A
authors: OA
authors: Oyekunle
mesh_terms: D000818:Animals; D005260:Female; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D017258:Medroxyprogesterone Acetate