title: Diffusion-weighted imaging of focal renal lesions: a meta-analysis.
abstract: OBJECTIVE
  Contrast-enhanced MRI can only distinguish to a limited extent between malignant and benign focal renal lesions. The aim of this meta-analysis is to review renal diffusion-weighted imaging (DWI) to compare apparent diffusion coefficient (ADC) values for different renal lesions that can be applied in clinical practice.
  
  
  METHODS
  A PubMed search was performed to identify relevant articles published 2004-2011 on renal DWI of focal renal lesions. ADC values were extracted by lesion type to determine whether benign or malignant. The data table was finalised in a consensus read. ADC values were evaluated statistically using meta-regression based on a linear mixed model. Two-sided P value <5 % indicated statistical significance.
  
  
  RESULTS
  The meta-analysis is based on 17 studies with 764 patients. Renal cell carcinomas have significant lower ADC values than benign tissue (1.61 ± 0.08 × 10(-3) mm(2)/s vs 2.10 ± 0.09 × 10(-3) mm(2)/s; P < 0.0001). Uroepithelial malignancies can be differentiated by lowest ADC values (1.30 ± 0.11 × 10(-3) mm(2)/s). There is a significant difference between ADC values of renal cell carcinomas and oncocytomas (1.61 ± 0.08 × 10(-3) mm(2)/s vs 2.00 ± 0.08 × 10(-3) mm(2)/s; P < 0.0001).
  
  
  CONCLUSIONS
  Evaluation of ADC values can help to determine between benign and malignant lesions in general but also seems able to differentiate oncocytomas from malignant tumours, hence potentially reducing the number of unnecessarily performed nephrectomies.
  
  
  CONCLUSIONS
  • This meta-analysis assesses the role of diffusion-weighted MRI in renal lesions. • ADC values obtained by DW MRI have been compared for different renal lesions. • ADC values can help distinguish between benign and malignant tumours. • Differentiating oncocytomas from malignant tumours can potentially reduce inappropriate nephrectomies.
authors: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, elke.lassel@umm.de.
authors: E A
authors: EA
authors: Lassel
authors: R
authors: R
authors: Rao
authors: C
authors: C
authors: Schwenke
authors: S O
authors: SO
authors: Schoenberg
authors: H J
authors: HJ
authors: Michaely
mesh_terms: D002292:Carcinoma, Renal Cell / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000175:diagnosis*