title: Aminoglycosides for life-threatening infections: a plea for an individualized approach using intensive therapeutic drug monitoring.
abstract: Aminoglycosides are potent antibiotics with a renewed interest due to the increase in multidrug resistant infections. Their use in life-threatening infections ‑ in combination with other antibiotics ‑ has been debated due to the lack of clear outcome benefits. However, based on recent pharmacokinetic-pharmacodynamic studies, conventional dosing may be inefficient in a considerable number of patients, which could preclude the efficiency of this potent drug class. Toxicity on the other hand remains a concern, with nephrotoxicity as the most relevant negative effect in the critically ill. Short term, intensively monitored treatment strategies - with monitoring both peak and trough levels - may increase efficacy as well as reduce toxicity in the critically ill patient.
authors: Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium - Jan.DeWaele@UGent.be.
authors: J J
authors: JJ
authors: De Waele
authors: N
authors: N
authors: De Neve
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D016638:Critical Illness / Q000628:therapy; D016903:Drug Monitoring; D006801:Humans; D057285:Precision Medicine
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents