title: Pyrrolizines: Promising scaffolds for anticancer drugs.
abstract: Pyrrolizine derivatives constitute a class of heterocyclic compounds which can serve as promising scaffolds for anticancer drugs. The unique antitumor properties of mitomycin C inspired chemists to develop different pyrrolizine systems and assess their potential antitumor activities against a wide variety of cancer types. Here we review the different classes of pyrrolizines that possess anticancer potency, with an emphasis on their structure activity relationships, in an effort to pave the way for further development in this promising area of research.
authors: Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taif University, Taif 21974, Saudi Arabia.
authors: Amany
authors: A
authors: Belal
authors: Chemistry Department, Faculty of Science, Benha University, Benha 13518, Egypt. Electronic address: bahaaeldin.adli@fsc.bu.edu.eg.
authors: Bahaa El-Dien M
authors: Bel-D
authors: El-Gendy
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011758:Pyrroles / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles
keywords: Anticancer drugs; Indolo pyrrolizine; Perhydropyrrolizines; Pyrimido pyrrolizines; Pyrrolizines; Pyrrolo pyrrolizine; SAR; Thieno pyrrolizines