title: Increased expression of kindlin 2 in luteinized granulosa cells correlates with androgen receptor level in patients with polycystic ovary syndrome having hyperandrogenemia.
abstract: Hyperandrogenemia is the leading defect in patients with polycystic ovary syndrome (PCOS) and considered to be involved in the ovulation dysfunction of PCOS. During the process of ovulation, granulosa cells (GCs) undergo epithelial-mesenchymal transition (EMT), and integrin-interacting protein kindlin 2 is a well-known regulator in EMT. Therefore, our objective here was to compare the expression levels of kindlin 2 in luteinized GCs between patients with PCOS and control women and the relationship between kindlin 2 and PCOS pathogenesis. In this study, kindlin 2 expression was significantly increased in luteinized GCs from patients with PCOS, and kindlin 2 could be induced by testosterone both in vitro and in vivo. Meanwhile, kindlin 2 was positively correlated with androgen receptor (AR) in PCOS GCs. Taken together, kindlin 2 may play a role in luteinized GCs, especially in the case of excess androgen. Further studies are required to assess the specific role of kindlin 2 in follicular development and PCOS pathogenesis.
authors: 1Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, and Laboratory of Stem Cell, Development and Reproductive Medicine, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing, China.
authors: Mei
authors: M
authors: Yang
authors: Juan
authors: J
authors: Du
authors: Danyu
authors: D
authors: Lu
authors: Caixia
authors: C
authors: Ren
authors: Huan
authors: H
authors: Shen
authors: Jie
authors: J
authors: Qiao
authors: Xi
authors: X
authors: Chen
authors: Hongquan
authors: H
authors: Zhang
mesh_terms: D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation; D006107:Granulosa Cells / Q000378:metabolism*; D006801:Humans; D017588:Hyperandrogenism / Q000453:epidemiology / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis*; D051379:Mice; D008813:Mice, Inbred ICR; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000378:metabolism*; D011944:Receptors, Androgen / Q000096:biosynthesis*
chemical_list: C410798:AR protein, human; C477322:FERMT3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011944:Receptors, Androgen
keywords: androgen; androgen receptor; kindlin 2; luteinized granulosa cells; polycystic ovary syndrome