title: Nanoparticles strengthen intracellular tension and retard cellular migration.
abstract: Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore , 4 Engineering Drive 4, Singapore 117585, Singapore.
authors: Chor Yong
authors: CY
authors: Tay
authors: Pingqiang
authors: P
authors: Cai
authors: Magdiel I
authors: MI
authors: Setyawati
authors: Wanru
authors: W
authors: Fang
authors: Lay Poh
authors: LP
authors: Tan
authors: Catherine H L
authors: CH
authors: Hong
authors: Xiaodong
authors: X
authors: Chen
authors: David Tai
authors: DT
authors: Leong
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D009061:Mouth Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D053758:Nanoparticles / Q000008:administration & dosage*; D013718:Tensile Strength / Q000502:physiology