title: Response profiles of cytokines and chemokines against avian H9N2 influenza virus within the mouse lung.
abstract: The circulation of H9N2 viruses throughout the world, along with their expanded host range, poses a potential health risk to the public, but the host responses to H9N2 virus in mammals were little known. To obtain insight into the host immune responses to the avian H9N2 virus, the expressions of both cytokines and chemokines in the lungs of infected mice were examined by real-time polymerase chain reaction and enzyme-linked immunosorbent assay. We found that interferon gamma (IFN-γ) was the dominant antiviral component, and IFN-γ-induced protein 10 kDa, interleukin 6, chemokine (C-C motif) ligand 5 and macrophage inflammatory protein-1 alpha all played a role in pro-inflammatory responses to H9N2 viruses. In conclusion, this research can make us further understand the infection characteristics of H9N2 virus in mammalian host by providing the data on mice lung immune responses to the avian H9N2 virus.
authors: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Street 61, 271018, Tai'an, China.
authors: Rong
authors: R
authors: Huang
authors: Jiyuan
authors: J
authors: Liu
authors: Wei
authors: W
authors: Liang
authors: Airong
authors: A
authors: Wang
authors: Zhihao
authors: Z
authors: Liu
authors: Yan
authors: Y
authors: Yang
authors: Jing
authors: J
authors: Lv
authors: Ying
authors: Y
authors: Bao
authors: Yanxia
authors: Y
authors: Gao
authors: Zengmin
authors: Z
authors: Miao
authors: Tongjie
authors: T
authors: Chai
mesh_terms: D000818:Animals; D018946:Chemokine CCL5 / Q000276:immunology; D005260:Female; D053127:Influenza A Virus, H9N2 Subtype / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D008168:Lung / Q000276:immunology* / Q000821:virology*; D019402:Macrophage Inflammatory Proteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000821:virology*
chemical_list: D018946:Chemokine CCL5; D015850:Interleukin-6; D019402:Macrophage Inflammatory Proteins; D007371:Interferon-gamma