title: Associations between maternal and infant morbidities and sRAGE within the first week of life in extremely preterm infants.
abstract: BACKGROUND
  Soluble RAGE (sRAGE) has been associated with multiple inflammatory responses including maternal chorioamnionitis and preeclampsia. Analysis of umbilical cord blood levels have also indicated that sRAGE levels in the infant are affected by maternal inflammation. S100b is a ligand for RAGE and increases in circulating S100b levels are associated with poor neurological outcome in preterm infants. The objective of this study was to determine whether sRAGE or s100b levels in plasma samples from extremely preterm infants at the end of the first week of life were correlated with infant morbidities and whether sRAGE and s100b levels at this time point were still associated with maternal inflammation.
  
  
  METHODS
  Plasma samples were collected from 130 preterm infants (≤28 weeks) at days of life 5, 6, or 7. sRAGE and s100b levels were measured by ELISA and data were analyzed by Pearson's correlation or Generalized Estimating Equations.
  
  
  RESULTS
  sRAGE was negatively correlated with development of sepsis (p=0.024), the FiO2 requirement of the infant at the time of sampling (p=0.030), as well as maternal preeclampsia (p=0.046), and positively correlated with maternal chorioamnionitis (p=0.006). s100b levels were positively associated with maternal chorioamnionitis (p=0.039). No correlations were observed with other infant morbidities.
  
  
  CONCLUSIONS
  These data indicate that sRAGE could potentially be a biomarker of early severe inflammatory responses in the preterm infant. However, more studies are needed to confirm the present findings.
authors: Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America ; Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America.
authors: Lynette K
authors: LK
authors: Rogers
authors: Amanda E
authors: AE
authors: Graf
authors: Anisha
authors: A
authors: Bhatia
authors: Karen L
authors: KL
authors: Leonhart
authors: Reena
authors: R
authors: Oza-Frank
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D005260:Female; D005865:Gestational Age; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood* / Q000453:epidemiology*; D009418:S100 Proteins / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced; D009418:S100 Proteins