title: STAG2 expression in oral cancer and potentially malignant lesions.
abstract: Oral cancer is a world health problem, and one of the highest incidence rates of oral cancer worldwide occurs in Brazil. STAG2 is part of the cohesin complex which is responsible for sister chromatid cohesion. STAG2 loss of expression was reported in a range of tumors, and STAG2 loss was found to cause chromosomal instability and aneuploidy in cancer cells. On the basis of these findings, we investigated STAG2 expression in oral cancer and potentially malignant lesions. We investigated STAG2 immunoexpression in oral cancer, lip cancer, oral leukoplakia, and actinic cheilitis, including complete clinical information. Normal oral mucosa samples were included as normal controls. STAG2 protein was highly expressed in all samples. We further tested STAG2 expression in gastric adenocarcinomas and glioblastomas, as these tumor types were previously shown to lose STAG2 expression. We found homogenous expression of STAG2 by these tumor cells. Our results suggest that STAG2 loss of expression is not a common event in oral carcinogenesis.
authors: Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, 31270-901, MG, Brazil.
authors: Vanessa Fátima
authors: VF
authors: Bernardes
authors: Gefter Thiago Batista
authors: GT
authors: Correa
authors: Adriano Mota
authors: AM
authors: Loyola
authors: Sérgio Vitorino
authors: SV
authors: Cardoso
authors: Alfredo Maurício Batista
authors: AM
authors: de Paula
authors: Mônica Maria Demas Álvares
authors: MM
authors: Cabral
authors: Ricardo Santiago
authors: RS
authors: Gomez
authors: Carolina Cavaliéri
authors: CC
authors: Gomes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034961:Antigens, Nuclear / Q000032:analysis*; D018797:Cell Cycle Proteins; D002613:Cheilitis / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005909:Glioblastoma / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000737:chemistry / Q000235:genetics; D008048:Lip Neoplasms / Q000737:chemistry / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000235:genetics*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics; D000097722:Cohesins
chemical_list: D034961:Antigens, Nuclear; D018797:Cell Cycle Proteins; C508565:STAG2 protein, human; D000097722:Cohesins