title: [The standardization of diagnostic of paroxysmal night hemoglobinuria cytometry].
abstract: The flow cytometry becomes a more and more largely applied technique. However, the sufficient novelty of technique has no worked-out standards of diagnostic of many diseases. The lacking of external control of quality promotes development of large variety of approaches to diagnostic of diseases and impossibility to compare the study results from different laboratories. The paroxysmal night hemoglobinuria is an acquired clonal disease characterized by proliferation of stem cells with partial or total loss of expression of glykosylphosphosphatidyl inositol anchor needed to conjugate a number of surface proteins. The flow cytometry is a basic technique of detection and monitoring of clone of paroxysmal night hemoglobinuria. The article presents the results of paroxysmal night hemoglobinuria testing of 8 patients in 6 independent laboratories using flow cytometry by standard protocol recommended by the International society of clinical cytometrists (ICCS).
authors: E V
authors: EV
authors: Naumova
authors: M E
authors: ME
authors: Potchtar
authors: D G
authors: DG
authors: Kisilitchina
authors: O S
authors: OS
authors: Plekhanova
authors: A A
authors: AA
authors: Sipol
authors: E V
authors: EV
authors: Babenko
authors: E V
authors: EV
authors: Boyakova
authors: T V
authors: TV
authors: Glazanova
authors: T V
authors: TV
authors: Tchubukina
authors: N V
authors: NV
authors: Pronkina
authors: A M
authors: AM
authors: Popov
authors: L I
authors: LI
authors: Saveliyev
authors: V I
authors: VI
authors: Borisov
authors: S A
authors: SA
authors: Lugovskaya
mesh_terms: D000328:Adult; D005260:Female; D005434:Flow Cytometry / Q000379:methods / Q000592:standards*; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged