title: Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study.
abstract: OBJECTIVE
  To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP).
  
  
  METHODS
  Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4).
  
  
  RESULTS
  The mean MD slopes were -0.55/-0.39 (right/left eyes, n = 19) dB/year in the treated group and -1.37/-1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values.
  
  
  CONCLUSIONS
  Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.
authors: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
authors: Mitsuru
authors: M
authors: Nakazawa
authors: Yukihiko
authors: Y
authors: Suzuki
authors: Tadashi
authors: T
authors: Ito
authors: Tomomi
authors: T
authors: Metoki
authors: Takashi
authors: T
authors: Kudo
authors: Hiroshi
authors: H
authors: Ohguro
mesh_terms: D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D012174:Retinitis Pigmentosa / Q000188:drug therapy* / Q000503:physiopathology*; D014794:Visual Fields / Q000187:drug effects*
chemical_list: D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine