title: Effect of Phaleria macrocarpa on Sperm Characteristics in Adult Rats.
abstract: OBJECTIVE
  The purpose of this study was to determine the effects of Phaleria macrocarpa (PM) on male fertility by assessing its effect on the sperm characteristics which included the sperm count, motility, viability and morphology.
  
  
  METHODS
  Eighteen male rats were equally divided into three groups. Each group of rats was orally supplemented for 7 weeks either with PM aqueous extract (240 mg/kg), distilled water (0 mg/kg) or testosterone hormone, Andriol® Testocaps™ (4 mg/kg) respectively. On the last day of supplementation period, the rats were sacrificed and sperm was obtained from cauda epididymis via orchidectomy. The sperm count, motility, viability and morphology were determined.
  
  
  RESULTS
  PM aqueous extract significantly increased (p<0.05) the percentage of sperm viability. However, there was no significant effect of PM on the percentage of both sperm motility and morphology. The mean of body weight declined significantly in rats supplemented with PM aqueous extract compared to control groups (p<0.05).
  
  
  CONCLUSIONS
  The results showed that PM significantly increased sperm viability without changing the sperm motility and morphology. Hence, this study suggests that PM offers an alternative way to improve male fertility by improving the sperm quality.
authors: Medicinal Plants Research Centre, Yasuj University of Medical Sciences (YUMS), Yasuj, Iran.
authors: Saadat
authors: S
authors: Parhizkar
authors: Maryam Jamielah
authors: MJ
authors: Yusoff
authors: Mohammad Aziz
authors: MA
authors: Dollah
keywords: Phaleria macrocarpa; Rats; Sperm Characteristics