title: [Radiotherapeutic concepts in cancer of unknown primary site].
abstract: BACKGROUND
  The term cancer of unknown primary (CUP) encompasses a group of entities which differ to a great extent regarding etiology, prognosis and therapeutic management.
  
  
  OBJECTIVE
  The aim of the study was an elaboration of the role of radiotherapy in CUP syndrome.
  
  
  METHODS
  Systematic literature search and specification of the available treatment options.
  
  
  RESULTS
  Radiotherapy is an integral part of interdisciplinary management approaches for patients with CUP in both curative and palliative situations. Radio-oncological techniques, such as intensity-modulated radiotherapy and stereotactic body radiotherapy increase the therapeutic window. Modern diagnostic modalities from radiology and nuclear medicine are the cornerstone of radiotherapeutic interventions, especially in terms of target volume definition and pretherapeutic staging. In the interdisciplinary setting radiation oncology offers the possibility of curative and often organ preserving approaches in patients with axillary and cervical CUP. In addition, improvement and preservation of quality of life can be achieved in patients with metastatic disease.
  
  
  CONCLUSIONS
  Radiation oncology is a crucial component of the interdisciplinary management of patients with CUP. Therapeutic decisions in patients with CUP should be made in an interdisciplinary setting.
authors: Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland, david.krug@med.uni-heidelberg.de.
authors: D
authors: D
authors: Krug
authors: J
authors: J
authors: Debus
authors: F
authors: F
authors: Sterzing
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000532:radiotherapy* / Q000601:surgery; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*