title: Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population.
abstract: The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer's disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position -491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the potential involvement of this polymorphism as a risk factor for AD, either through an independent effect or through interaction with the existing APOE ε4 allele risk. The T allele frequency was significantly higher in the AD patients group (45.3 %) than in the controls group (32.78 %) and may possibly constitute a significant risk factor for AD. The APOE ε4 allele did not influence the distribution of the -491 polymorphism after stratification.
authors: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia, achouriafef@yahoo.fr.
authors: Afef
authors: A
authors: Achouri-Rassas
authors: Sondes
authors: S
authors: Hadj Fredj
authors: Hela
authors: H
authors: Mrabet Khiari
authors: Amina
authors: A
authors: Bibi
authors: Hajer
authors: H
authors: Siala
authors: Amel
authors: A
authors: Mrabet
authors: Taieb
authors: T
authors: Messaoud
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D014416:Tunisia
chemical_list: D001057:Apolipoproteins E; D017931:DNA Primers