title: Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
abstract: Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.
authors: Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland.
authors: Timothy J
authors: TJ
authors: Foster
authors: Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland.
authors: Joan A
authors: JA
authors: Geoghegan
authors: Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas 77030, USA.
authors: Vannakambadi K
authors: VK
authors: Ganesh
authors: Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas 77030, USA.
authors: Magnus
authors: M
authors: Höök
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D002473:Cell Wall / Q000737:chemistry; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D010457:Peptidoglycan / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D013211:Staphylococcus aureus / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D010457:Peptidoglycan; D037521:Virulence Factors