title: Intractable glaucoma necessitating dexamethasone implant (Ozurdex) removal and glaucoma surgery in a child with uveitis.
abstract: Although there are encouraging reports showing the use of dexamethasone implant (Ozurdex) in uveitis in adults, the literature is scanty regarding its benefits and side effects in children. A 12-year-old boy presented with intermediate uveitis with disc oedema. He had 20/20 visual acuity and intraocular pressure (IOP) of 18 mm Hg in both eyes. He was treated with intravitreal Ozurdex in his left eye (LE) due to progressive worsening of uveitis and disc oedema. He developed increased IOP (31 mm Hg) that could not be controlled on maximal antiglaucoma medications and required the removal of the Ozurdex implant at 2.5 months. His IOP remained persistently high leading to increased cup disc ratio necessitating glaucoma filtration surgery (GFS). At 9 months of post-GFS follow-up, IOP was 12 mm Hg in LE without any medication. Though dexamethasone implant is being increasingly used in children with uveitis, its potential risk factors such as intractable glaucoma should be considered.
authors: Advanced Eye Centre, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Neha
authors: N
authors: Kumari
authors: Swapnil
authors: S
authors: Parchand
authors: Sushmita
authors: S
authors: Kaushik
authors: Ramandeep
authors: R
authors: Singh
mesh_terms: D002648:Child; D020878:Device Removal; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004343:Drug Implants / Q000009:adverse effects; D005901:Glaucoma / Q000139:chemically induced* / Q000601:surgery*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D014605:Uveitis / Q000188:drug therapy*
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone