title: Is prepregnancy obesity associated with risk of cerebral palsy and epilepsy in children?
abstract: We conducted a retrospective cohort study to investigate the association between prepregnancy obesity in women and risk of cerebral palsy and epilepsy in their children using data from the South Carolina Medicaid program. The cohort included 83,901 maternal-child pairs; 100 cases of cerebral palsy were initially identified, followed by 53 cases that had at least 2 cerebral palsy diagnoses. For confirmed epilepsy, diagnosed on at least 5 occasions or by more than 1 provider, 83,472 observations were included with 338 cases. There was no association between maternal body mass index and risk of childhood epilepsy. A significant association between increasing maternal body mass index and any diagnosis of cerebral palsy was found, and morbid obesity was associated with increased risk of any and confirmed cerebral palsy. In conclusion, there appears to be an association of maternal body mass index with cerebral palsy, but there is no evidence to support an association with epilepsy.
authors: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
authors: Chun
authors: C
authors: Pan
authors: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
authors: Chelsea B
authors: CB
authors: Deroche
authors: Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, SC, USA| joshua.mann@uscmed.sc.edu.
authors: Joshua R
authors: JR
authors: Mann
authors: Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, SC, USA|
authors: Suzanne
authors: S
authors: McDermott
authors: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
authors: James W
authors: JW
authors: Hardin
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002547:Cerebral Palsy / Q000150:complications / Q000209:etiology*; D015331:Cohort Studies; D004827:Epilepsy / Q000150:complications / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D055815:Young Adult
keywords: body mass index; cerebral palsy; epilepsy; obesity