title: Insight into the pathogenesis of fetal growth restriction in placental malaria: decreased placental glucose transporter isoform 1 expression.
abstract: Placental malaria, especially when complicated with intervillositis, can cause fetal growth restriction. Transplacental glucose transport by glucose transporter isoform 1 (GLUT-1) on the syncytiotrophoblast microvillous and basal plasma membranes regulates fetal growth. We found that GLUT-1 expression in the microvillous plasma membrane of Plasmodium falciparum-negative placenta biopsy specimens was comparable to that in P. falciparum-positive placenta biopsy specimens with or without intervillositis, whereas GLUT-1 expression in the basal plasma membrane was lowest in P. falciparum-positive placenta biopsy specimens with intervillositis, compared with the other 2 specimen types (P ≤ .0016). GLUT-1 expression in the basal plasma membrane also correlated negatively with monocyte infiltrate density (r = -0.43; P = .003) and positively with birth weight (r = 0.28; P = .06). These findings suggest that intervillositis, more than placental malaria per se, might cause fetal growth restriction, through impaired transplacental glucose transport.
authors: Department of Medicine, University of Melbourne.
authors: Upeksha P
authors: UP
authors: Chandrasiri
authors: Caroline L L
authors: CL
authors: Chua
authors: Alexandra J
authors: AJ
authors: Umbers
authors: Ebbie
authors: E
authors: Chaluluka
authors: Jocelyn D
authors: JD
authors: Glazier
authors: Stephen J
authors: SJ
authors: Rogerson
authors: Philippe
authors: P
authors: Boeuf
mesh_terms: D000293:Adolescent; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D051272:Glucose Transporter Type 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000150:complications*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000378:metabolism; D055815:Young Adult
chemical_list: D051272:Glucose Transporter Type 1
keywords: GLUT-1; Plasmodium falciparum; fetal growth restriction; glucose transport; intervillositis; malaria; monocytes; pregnancy; syncytiotrophoblast