title: Effects of exercise training programs on physical performance and quality of life in patients with metastatic lung cancer undergoing palliative chemotherapy--a study protocol.
abstract: OBJECTIVE
  The aims of the study protocol are to investigate different adapted physical training programs in patients with advanced lung cancer undergoing palliative chemo- or radiotherapy and to evaluate their effects on physical performance, quality of life, symptom burden, and efficacy of oncologic treatment.
  
  
  METHODS
  Patients will be randomized into three study arms: interventional group 1 performing aerobic exercise, interventional group 2 performing resistance training, and a control group without specific physical training. Interventional training will be performed for 12 weeks consisting of two supervised and one self-instructed training sessions per week each. Respiratory therapy over 12 weeks is provided in all three study arms as an established supportive therapy in lung cancer patients. Primary efficacy endpoint is physical performance measured by peak oxygen consumption (VO(2)peak). Secondary efficacy endpoints include additional parameters of physical performance (resistance, lung function, perceived exertion, level of physical activity and IPAQ-questionnaire), health-related quality of life (EORTC QLQ C30-questionnaire), disease and treatment related symptoms (Memorial Symptom Assessment Scale), biologic parameter (e.g. body composition, blood values of immune system, chronic inflammation, glucose and lipid metabolisms), and parameter of efficacy of oncologic treatment.
  
  
  CONCLUSIONS
  The results of this study will offer an overview over possible effects of specific training interventions on health related quality of life, physical and psychological symptoms, and on the efficacy of oncologic treatment. The primary aim of this study is to detect adapted intervention programs for metastatic lung cancer undergoing palliative chemotherapy.
authors: Department of Oncology/Hematology/Bone marrow Transplantation/Pneumology, University Medical Center Eppendorf, Hamburg, Germany. Electronic address: w.jensen@uke.de.
authors: Wiebke
authors: W
authors: Jensen
authors: Department of Oncology/Hematology/Bone marrow Transplantation/Pneumology, University Medical Center Eppendorf, Hamburg, Germany.
authors: Karin
authors: K
authors: Oechsle
authors: Department of Oncology/Hematology/Bone marrow Transplantation/Pneumology, University Medical Center Eppendorf, Hamburg, Germany.
authors: Hans Jörg
authors: HJ
authors: Baumann
authors: Section of Psychosocial Oncology, Department of Medical Psychology and Medical Sociology, University Medical Center, Leipzig, Germany.
authors: Anja
authors: A
authors: Mehnert
authors: Department of Oncology/Hematology/Bone marrow Transplantation/Pneumology, University Medical Center Eppendorf, Hamburg, Germany.
authors: Hans
authors: H
authors: Klose
authors: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
authors: Wilhelm
authors: W
authors: Bloch
authors: Department of Oncology/Hematology/Bone marrow Transplantation/Pneumology, University Medical Center Eppendorf, Hamburg, Germany.
authors: Carsten
authors: C
authors: Bokemeyer
authors: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
authors: Freerk T
authors: FT
authors: Baumann
mesh_terms: D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D010101:Oxygen Consumption; D010166:Palliative Care; D010809:Physical Fitness; D011788:Quality of Life; D055070:Resistance Training / Q000379:methods
keywords: Aerobic exercise training; Cardio-respiratory fitness; Lung cancer; Palliative chemotherapy; Quality of life; Resistance training