title: Changes in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease.
abstract: In a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this purpose, plasma levels of von Willebrand factor (vWF), thrombomodulin, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor pathway inhibitor (TFPI) in patients with NAFLD were measured. There was a significant difference in vWF and TFPI levels between patient and control groups (P < 0.05). However, no statistically significant difference was obtained in PAI-1, uPA, and thrombomodulin levels between the two groups (P > 0.05). According to our results, an increase in vWF and TFPI levels indicates an endothelial injury in NAFLD cases.
authors: aDepartment of Hematology, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir bDepartment of Allergy and Immunology, Celal Bayar University Medical School, Manisa cDepartment of Biochemistry, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir dDepartment of Endocrine and Metabolism, Dokuz Eylul University Medical School, Izmir, Turkey.
authors: Oktay
authors: O
authors: Bilgir
authors: Ferda
authors: F
authors: Bilgir
authors: Giray
authors: G
authors: Bozkaya
authors: Mehmet
authors: M
authors: Calan
mesh_terms: D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D005234:Fatty Liver / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012307:Risk Factors; D018180:Thrombomodulin / Q000097:blood; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D014841:von Willebrand Factor; D014568:Urokinase-Type Plasminogen Activator