title: Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis.
abstract: OBJECTIVE
  To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA).
  
  
  METHODS
  Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses.
  
  
  RESULTS
  Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03).
  
  
  CONCLUSIONS
  Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA.
authors: From the Arthritis Program, Toronto Western Hospital, University Health Network; Institute of Health Policy, Management and Evaluation; Toronto Musculoskeletal Centre, University of Toronto; Division of Orthopedic Surgery, Department of Surgery, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors: Anthony V
authors: AV
authors: Perruccio
authors: Nizar N
authors: NN
authors: Mahomed
authors: Vinod
authors: V
authors: Chandran
authors: Rajiv
authors: R
authors: Gandhi
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D017281:Cost of Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000097:blood* / Q000150:complications; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000150:complications; D010146:Pain / Q000097:blood* / Q000150:complications; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: ADIPOKINES; HIP; JOINTS; KNEE; OSTEOARTHRITIS