title: Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice.
abstract: Streptozotocin (STZ)-induced diabetes in mice progresses with decreased desaturase activities and alterations in the metabolism of essential fatty acids (EFA).
  
  
  OBJECTIVE
  Based on our previous studies with soybean oil that ameliorated the STZ damage in mice, we tested here the accountability of its main EFA components, i.e. linoleic acid (LA) and alpha linolenic acid (ALA), in the prevention of pancreas damage and Δ6 desaturase decrease.
  
  
  METHODS
  Seven days after injection with STZ and EFA gavage, ICR mice were sacrificed. Plasma glucose and insulin levels, pancreas histology and liver fatty acid desaturases were analysed.
  
  
  RESULTS
  EFA reduced pancreas damage, insulin and glucose plasma levels and restored Δ6 desaturase activity and mRNA expression levels.
  
  
  CONCLUSIONS
  By reducing pancreas damage, EFA ameliorated insulin levels, Δ6 desaturase and fatty acid metabolism. LA further enhanced Fads2 promoter activity.
  
  
  CONCLUSIONS
  EFA ameliorate STZ induced diabetes in mice.
authors: Minerva Center for Cholesterol, Gallstones Research, and Lipid Metabolism in the Liver and.
authors: Lea
authors: L
authors: Canetti
authors: Haim
authors: H
authors: Werner
authors: Alicia
authors: A
authors: Leikin-Frenkel
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000517:prevention & control; D004032:Diet; D056945:Hep G2 Cells; D006801:Humans; D019787:Linoleic Acid / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D050602:Linoleoyl-CoA Desaturase / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D017962:alpha-Linolenic Acid / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D017962:alpha-Linolenic Acid; D019787:Linoleic Acid; D050602:Linoleoyl-CoA Desaturase