title: Usefulness of 18F-fluorodeoxyglucose positron emission tomography as predictor of distant metastasis in preoperative carbon-ion radiotherapy for pancreatic cancer.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the role of FDG-PET regarding the indication of preoperative carbon-ion radiotherapy (CIRT) for pancreatic cancer patients.
  
  
  METHODS
  Patients with resectable pancreatic cancer underwent preoperative CIRT. The impact of baseline SUVmax on prognosis for patients was assessed by analyzing correlations with distant metastasis-free survival (DMFS) and overall survival (OS).
  
  
  RESULTS
  Out of 21 patients, local recurrence was observed in no patient and distant metastasis was found in 13 patients (62%). 1-year DMFS and OS in low-SUVmax group were significantly higher than those in high-SUVmax group (91% vs. 20% and 91% vs. 56%). SUVmax was significantly correlated with DMFS and OS.
  
  
  CONCLUSIONS
  Our data indicated a significant correlation between SUVmax and DMFS. FDG-PET might be useful for determining the indication of preoperative short-course CIRT for patients with resectable pancreatic cancer.
authors: Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan, 415 Harakoga-machi, Tosu, 841-0071, Japan. shinoto@saga-himat.jp.
authors: Makoto
authors: M
authors: Shinoto
authors: Shigeru
authors: S
authors: Yamada
authors: Kyosan
authors: K
authors: Yoshikawa
authors: Shigeo
authors: S
authors: Yasuda
authors: Yoshiyuki
authors: Y
authors: Shioyama
authors: Hiroshi
authors: H
authors: Honda
authors: Tadashi
authors: T
authors: Kamada
authors: Hirohiko
authors: H
authors: Tsujii
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D049268:Positron-Emission Tomography / Q000379:methods*; D011300:Preoperative Care; D016019:Survival Analysis
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: FDG-PET; carbon-ion radiotherapy; distant metastasis; preoperative; prognostic factor