title: Oleanane type glycosides from Paronychia anatolica subsp. balansae.
abstract: Four new oleanane-type triterpene glycosides were isolated from the methanol extract of the roots of Paronychia anatolica subsp. balansae along with three known oleanane-type triterpene glycosides. Structures of the new compounds were established as 3-O-β-D-glucuronopyranosyl-28-O-[α-L-rhamnopyranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 3-O-β-D-glucuronopyranosyl-28-O-[β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 3-O-β-D-glucuronopyranosyl-28-O-[α-L-arabinofuranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 28-O-[α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-medicagenic acid, by using 1D and 2D-NMR techniques and mass spectrometry. The cytotoxic activity of the isolated compounds was evaluated against a small panel of cancer cell lines including human breast cancer (MCF-7), human lung adenocarcinoma (A549) and human leukemia (U937) cell lines.
authors: Chemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey. Electronic address: derya.gulcemal@ege.edu.tr.
authors: Derya
authors: D
authors: Gülcemal
authors: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, I-84084 Fisciano (SA), Italy.
authors: Milena
authors: M
authors: Masullo
authors: Chemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey.
authors: Özgen
authors: Ö
authors: Alankuş-Çalışkan
authors: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, I-84084 Fisciano (SA), Italy. Electronic address: piacente@unisa.it.
authors: Sonia
authors: S
authors: Piacente
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D010936:Plant Extracts; D012503:Saponins
keywords: Illecebraceae; Oleanane; Paronychia anatolica subsp. balansae; Saponins