title: Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.
abstract: OBJECTIVE
  The study goal was to determine the effect of weight loss (WL) alone and with aerobic exercise (WL + AEX) on serum amyloid A (SAA) levels and adipose SAA secretion from gluteal and abdominal depots.
  
  
  METHODS
  Ninety-six overweight or obese postmenopausal women undertook a 6-month WL alone (n = 47) or with AEX training (n = 49) (6 months WL and WL + AEX are considered WL when groups were combined). Their serum SAA levels, body weight, and adipose SAA secretion ex vivo from gluteal and abdominal depot were measured before and after WL interventions.
  
  
  RESULTS
  The participants lost an average of 8% body weight with a 10% decrease of serum SAA. Serum SAA levels remained significantly correlated with body weight before and after WL. However, the changes of serum SAA level did not correlate with changes of body weight. The gluteal adipose tissue secreted ∼50% more SAA than the abdominal tissue, but the changes of abdominal, but not gluteal, SAA secretion correlated (R(2) = 0.19, p < 0.01) with those of serum SAA levels during WL.
  
  
  CONCLUSIONS
  No linear correlation between the decrease in systemic SAA and WL was found. There is a depot-dependent difference in adipose SAA secretion and abdominal SAA secretion, which may partially account for the systemic SAA reduction during WL.
authors: Division of Endocrinology Diabetes and Nutrition, University of Maryland School of Medicine at Baltimore, Baltimore, Maryland, USA.
authors: Rong-Ze
authors: RZ
authors: Yang
authors: Jacob B
authors: JB
authors: Blumenthal
authors: Nicole M
authors: NM
authors: Glynn
authors: Mi-Jeong
authors: MJ
authors: Lee
authors: Andrew P
authors: AP
authors: Goldberg
authors: Da-Wei
authors: DW
authors: Gong
authors: Alice S
authors: AS
authors: Ryan
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D050177:Overweight / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D000685:Serum Amyloid A Protein / Q000032:analysis / Q000378:metabolism*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D061217:Weight Reduction Programs
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein