title: Prognostic factors and status of hormone receptors and angiogenic factors in uterine carcinosarcoma.
abstract: OBJECTIVE
  To determine novel prognostic factors and treatment modalities for uterine carcinosarcoma (UCS).
  
  
  METHODS
  We performed immunohistochemical staining of estrogen receptor (ER)-α, ER-β, progesterone receptor, gonadotropin-releasing hormone receptor, vascular endothelial growth factor (VEGF), platelet-derived endothelial cell growth factor (PD-ECGF) and platelet-derived growth factor receptor (PDGFR)-β in a clinicopathological study of 15 UCS patients.
  
  
  RESULTS
  No significant differences were found between the sarcomatous and carcinomatous components with respect to expression of ER-α, ER-β and progesterone receptor. However, VEGF was significantly more frequently expressed in the carcinomatous component, while PD-ECGF and PDGFR-β were significantly more frequently expressed in the sarcomatous component. Only one patient showed gonadotropin-releasing hormone receptor expression in the sarcomatous component. Moreover, ER-β expression in resected specimens, increased serum levels of carbohydrate antigen (CA)-125 and C-reactive protein (CRP), and thrombocytosis were determined as significant UCS prognostic factors.
  
  
  CONCLUSIONS
  Combination of anti-VEGF therapy and anti-PD-ECGF or anti-PDGFR-β therapy would be expected in advanced or recurrent UCS. Furthermore, careful monitoring for early detection of recurrence should be performed when UCS patients showed preoperative increase in serum CA-125 levels, CRP and platelet counts, and ER-β expression in biopsied or surgically resected specimens.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Kinki University, Osaka, Japan.
authors: Tomomaro
authors: T
authors: Etoh
authors: Hidekatsu
authors: H
authors: Nakai
mesh_terms: D000368:Aged; D042501:Angiogenic Proteins / Q000378:metabolism*; D002296:Carcinosarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D008875:Middle Aged; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D064887:Observational Studies as Topic; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012189:Retrospective Studies; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D042501:Angiogenic Proteins; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface
keywords: angiogenic receptor; hormone receptor; immunohistochemical staining; prognostic factor; uterine carcinosarcoma