title: Carboxylation with CO2 via Brook rearrangement: preparation of α-hydroxy acid derivatives.
abstract: In the presence of CsF, a wide range of α-substituted α-siloxy silanes were carboxylated under a CO2 atmosphere (1 atm) via Brook rearrangement. A variety of α-substituents including aryl, alkenyl, and alkyl groups were tolerated to afford α-hydroxy acids in moderate-to-high yields. One-pot synthesis from aldehydes using PhMe2SiLi and CO2 was also possible, providing α-hydroxy acids without the isolation of an α-hydroxy silane.
authors: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors: Tsuyoshi
authors: T
authors: Mita
authors: Yuki
authors: Y
authors: Higuchi
authors: Yoshihiro
authors: Y
authors: Sato
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry*; D006880:Hydroxy Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D006880:Hydroxy Acids; D009942:Organometallic Compounds; D002245:Carbon Dioxide