title: Quality of life assessed with EQ-5D in patients undergoing glioma surgery: what is the responsiveness and minimal clinically important difference?
abstract: OBJECTIVE
  To evaluate the responsiveness of EQ-5D 3L in patients undergoing intracranial glioma surgery and estimate the minimal clinically important difference (MCID).
  
  
  METHODS
  EQ-5D 3L index values from 164 patients who underwent glioma surgery in the period 2007-2012 were analysed. Responsiveness and MCID were estimated using a combination of distribution-based and anchor-based methods. Karnofsky performance status served as an anchor.
  
  
  RESULTS
  Patients who improved functionally did not report significantly higher EQ-5D 3L scores post operatively with a standardized response mean (SRM) of 0.04 (p = 0.13). Patients who deteriorated functionally reported significantly lower EQ-5D 3L scores post operatively with a SRM of 0.72 (p < 0.001). With different approaches, we determined a range of MCID values from 0.13 to 0.15.
  
  
  CONCLUSIONS
  EQ-5D 3L is responsive to changes when glioma patients are deteriorating functionally after surgery but not responsive when the patients are improving. The MCID values for EQ-5D 3L in glioma surgery seem higher than reported MCID values for other types of cancers.
authors: Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway, lisa.millgard.sagberg@ntnu.no.
authors: Lisa Millgård
authors: LM
authors: Sagberg
authors: Asgeir S
authors: AS
authors: Jakola
authors: Ole
authors: O
authors: Solheim
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000523:psychology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003430:Cross-Sectional Studies; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000523:psychology* / Q000601:surgery; D006305:Health Status Indicators; D006801:Humans; D017567:Karnofsky Performance Status / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000523:psychology; D009664:Norway; D011184:Postoperative Period; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires / Q000592:standards*; D013997:Time Factors; D016896:Treatment Outcome; D064232:Visual Analog Scale