title: Study of liver transplant rejection in alcoholism-induced cirrhosis.
abstract: Rejection is the most usual cause of primary dysfunction of hepatic allograft transplants. Acute rejection (AR) often occurs in the early post-transplantation weeks, with an incidence of 12%-19%. Chronic rejection (CR) is less usual (2.5%-17%) and irreversible. Our aim was to determine the incidence of AR and CR in patients who underwent transplantaton due to alcoholism-induced cirrhosis and the survival of these groups. We undertook a retrospective study of the 93 patients who received a liver transplant due to hepatic cirrhosis between 2005 and 2012. AR occurred in 23.7% of cases, and CR in 11.8%. The median time from implantation to the appearance of AR was 34.5 days, and for CR it was 334 days. The survival of the patients with AR and CR showed no significant differences as compared with the control group (P = .77). From our clinical appraisal, symptoms of previous AR may lead to CR, although the relationship was not significant.
authors: General Surgery and Digestive, Hepatobiliopancreatic Surgery, Virgen del Rocio University Hospitals, Seville, Spain. Electronic address: tinoko243@hotmail.com.
authors: J Tinoco
authors: JT
authors: González
authors: C Bernal
authors: CB
authors: Bellido
authors: G Jimenez
authors: GJ
authors: Riera
authors: V Camacho
authors: VC
authors: Marente
authors: L M Marín
authors: LM
authors: Gómez
authors: G Suárez
authors: GS
authors: Artacho
authors: J M Álamo
authors: JM
authors: Martínez
authors: J Serrano
authors: JS
authors: Díez-Canedo
authors: R J Padillo
authors: RJ
authors: Ruíz
authors: M A Gómez
authors: MA
authors: Bravo
mesh_terms: D000208:Acute Disease; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome