title: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
abstract: Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.
authors: Science for Life Laboratory, KTH - Royal Institute of Technology, SE-171 21 Stockholm, Sweden;
authors: Linn
authors: L
authors: Fagerberg
authors: Björn M
authors: BM
authors: Hallström
authors: Per
authors: P
authors: Oksvold
authors: Caroline
authors: C
authors: Kampf
authors: Dijana
authors: D
authors: Djureinovic
authors: Jacob
authors: J
authors: Odeberg
authors: Masato
authors: M
authors: Habuka
authors: Simin
authors: S
authors: Tahmasebpoor
authors: Angelika
authors: A
authors: Danielsson
authors: Karolina
authors: K
authors: Edlund
authors: Anna
authors: A
authors: Asplund
authors: Evelina
authors: E
authors: Sjöstedt
authors: Emma
authors: E
authors: Lundberg
authors: Cristina Al-Khalili
authors: CA
authors: Szigyarto
authors: Marie
authors: M
authors: Skogs
authors: Jenny Ottosson
authors: JO
authors: Takanen
authors: Holger
authors: H
authors: Berling
authors: Hanna
authors: H
authors: Tegel
authors: Jan
authors: J
authors: Mulder
authors: Peter
authors: P
authors: Nilsson
authors: Jochen M
authors: JM
authors: Schwenk
authors: Cecilia
authors: C
authors: Lindskog
authors: Frida
authors: F
authors: Danielsson
authors: Adil
authors: A
authors: Mardinoglu
authors: Asa
authors: A
authors: Sivertsson
authors: Kalle
authors: K
authors: von Feilitzen
authors: Mattias
authors: M
authors: Forsberg
authors: Martin
authors: M
authors: Zwahlen
authors: IngMarie
authors: I
authors: Olsson
authors: Sanjay
authors: S
authors: Navani
authors: Mikael
authors: M
authors: Huss
authors: Jens
authors: J
authors: Nielsen
authors: Fredrik
authors: F
authors: Ponten
authors: Mathias
authors: M
authors: Uhlén
mesh_terms: D000906:Antibodies / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D023281:Genomics / Q000379:methods*; D006801:Humans; D008297:Male; D009928:Organ Specificity / Q000235:genetics*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D018511:Systems Integration; D046888:Tissue Array Analysis; D059467:Transcriptome
chemical_list: D000906:Antibodies; D011506:Proteins; D020543:Proteome