title: Highly regioselective three-component domino Heck-Negishi coupling reaction for the functionalization of purines at C6.
abstract: A highly regioselective three-component domino Heck-Negishi coupling reaction has been developed. Organozinc reagents are used to trap an alkylpalladium intermediate of olefins for a first example in the domino Heck reaction. This reaction is applicable to acrylates (or acrylamides) and purine compounds, producing a series of novel purine compounds with carbon substituents at the C6 position in moderate to good yields.
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, P. R. China.
authors: Dong-Chao
authors: DC
authors: Wang
authors: Hong-Ying
authors: HY
authors: Niu
authors: Ming-Sheng
authors: MS
authors: Xie
authors: Gui-Rong
authors: GR
authors: Qu
authors: Hui-Xuan
authors: HX
authors: Wang
authors: Hai-Ming
authors: HM
authors: Guo