title: Polyketides from the halotolerant fungus Myrothecium sp. GS-17.
abstract: Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1-hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.
authors: Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China. taoliu0307@163.com.
authors: Tao
authors: T
authors: Liu
authors: Jing
authors: J
authors: Zhu
authors: Song-Ya
authors: SY
authors: Zhang
authors: Zhan-Lin
authors: ZL
authors: Li
authors: Li-Ping
authors: LP
authors: Guan
authors: Hua-Qi
authors: HQ
authors: Pan
authors: Xin
authors: X
authors: Wu
authors: Jiao
authors: J
authors: Bai
authors: Hui-Ming
authors: HM
authors: Hua
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry*
chemical_list: D061065:Polyketides