title: Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus.
abstract: Over the last decade, cytomegalovirus (CMV) has been suggested to promote the development of glioblastoma multiforme (GBM). Recent evidence demonstrates that CMV contributes to the progression of GBM in the context of oncosuppressor gene mutations. This finding provides further insights into the mechanisms whereby CMV exacerbates the malignancy of GBM.
authors: Department of Neurosurgery; University of Michigan Health System; Ann Arbor, MI USA.
authors: Todd C
authors: TC
authors: Hollon
authors: Richard L
authors: RL
authors: Price
authors: Chang-Hyuk
authors: CH
authors: Kwon
authors: E Antonio
authors: EA
authors: Chiocca
keywords: brain tumor; glioma; rhabdomyosarcoma; tumor suppressor genes; viral oncology