title: Inflammation in neurodegenerative diseases--an update.
abstract: Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal degeneration is well-known in Alzheimer's and Parkinson's diseases, it is also observed in neurotrophic infections, traumatic brain and spinal cord injury, stroke, neoplastic disorders, prion diseases, multiple sclerosis and amyotrophic lateral sclerosis, as well as neuropsychiatric disorders and genetic disorders. A common link between these diseases is chronic activation of innate immune responses including those mediated by microglia, the resident CNS macrophages. Such activation can trigger neurotoxic pathways leading to progressive degeneration. Yet, microglia are also crucial for controlling inflammatory processes, and repair and regeneration. The adaptive immune response is implicated in neurodegenerative diseases contributing to tissue damage, but also plays important roles in resolving inflammation and mediating neuroprotection and repair. The growing awareness that the immune system is inextricably involved in mediating damage as well as regeneration and repair in neurodegenerative disorders, has prompted novel approaches to modulate the immune system, although it remains whether these approaches can be used in humans. Additional factors in humans include ageing and exposure to environmental factors such as systemic infections that provide additional clues that may be human specific and therefore difficult to translate from animal models. Nevertheless, a better understanding of how immune responses are involved in neuronal damage and regeneration, as reviewed here, will be essential to develop effective therapies to improve quality of life, and mitigate the personal, economic and social impact of these diseases.
authors: Department of Pathology, VU University Medical Centre, Amsterdam, the Netherlands; Neuroimmunology Unit, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK.
authors: Sandra
authors: S
authors: Amor
authors: Laura A N
authors: LA
authors: Peferoen
authors: Daphne Y S
authors: DY
authors: Vogel
authors: Marjolein
authors: M
authors: Breur
authors: Paul
authors: P
authors: van der Valk
authors: David
authors: D
authors: Baker
authors: Johannes M
authors: JM
authors: van Noort
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000628:therapy
keywords: central nervous system; inflammation; innate; neurodegeneration; neuroprotection; repair