title: Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties.
abstract: OBJECTIVE
  Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available. Oral route is the selective method for administration of most of the drugs. The aim of this study was formulating 'for oral' cefuroxime axetil suspensions.
  
  
  METHODS
  Minitab (ver.15) was used to design the formulations containing 125 mg of cefuroxime in 5 ml vehicle. After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed.
  
  
  RESULTS
  From all 33 formulations, only 9 were selected to further investigation. Considering no sedimentation, the sedimentation volume was determined to be 1. The degrees of flocculation were also equal to 1. All selected formulations released the drug between 81-100% in 30 minutes which was acceptable according to the USP32 criteria. The results of assay test also proved that all formulations contain the drug in acceptable range (91-106%). The viscosity curves showed that the systems were pseudo plastic and thixotrop.
  
  
  CONCLUSIONS
  Designed cefuroxime axetil formulations had good qualities and could be added as a new product to Iran drug marketing.
authors: Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran ; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Hadi
authors: H
authors: Valizadeh
authors: Aynoor
authors: A
authors: Farajnia
authors: Parvin
authors: P
authors: Zakeri-Milani
keywords: cefuroxime axetil; degree of flocculation; oral suspension; sedimentation volume; viscosity; zeta potential