title: Prevalence of oral and systemic manifestations in pediatric HIV cohorts with and without drug therapy.
abstract: The prevalence of orofacial and systemic manifestations and their association with drug therapy in pediatric HIV patients is scarce in the literature. The aim of the study was to determine the prevalence of oro-facial and systemic manifestations in HIV sero-positive children with and without highly active antiretroviral therapy (HAART). The study population consisted of 100 pediatric HIV patients (n=47 on HAART and n=53 not on HAART). The majority of the children (n=56) had at least one or more oro-facial manifestation associated with HIV. Oral candidiasis was the most common oral finding present in the HAART (14/33) and non-HAART groups (19/33). Recurrent aphthous ulcers was the only significant oral finding, present more in the HAART group. The percentage of children with upper respiratory tract infection was also more in the HAART group. The other lesions which were found to be significant were seborrheic dermatitis, pulmonary tuberculosis and otitis media. There was no significant difference in the participants' oral findings based on CD4 counts in the HAART and non- HAART groups. The prevalence of oral and systemic manifestations is a persistent feature associated with pediatric HIV, though of moderate intensity in those using HAART and may vary according to individual immune status.
authors: Renju
authors: R
authors: Jose
authors: Sharath
authors: S
authors: Chandra
authors: Jaishankar H
authors: JH
authors: Puttabuddi
authors: Sajith
authors: S
authors: Vellappally
authors: Abul-Aziz A
authors: AA
authors: Al Khuraif
authors: Hassan S
authors: HS
authors: Halawany
authors: Nimmi B
authors: NB
authors: Abraham
authors: Vimal
authors: V
authors: Jacob
authors: Dental Caries Research Chair, P.O. Box 60169, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia. nimmibaksu@gmail.com.
authors: Mohamed
authors: M
authors: Hashim
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008206:Lymphatic Diseases / Q000453:epidemiology; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology; D012871:Skin Diseases / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents