title: Protective effect of ginger on gentamicin-induced apoptosis in testis of rats.
abstract: OBJECTIVE
  Ginger, the rhizome of Zingiber officinale, is one of the most widely used spices for various foods and as an herbal medicine in Asian countries. It has been shown that ginger has antioxidant power. Gentamicin is an aminoglycoside antibiotic with a very broad spectrum against microbial pathogens, especially the gram-negative. Many studies revealed that gentamicin induces an oxidative stress-status in the testis by increasing free radical formation and lipid peroxidation. The present study was designed to investigate on the effects of Ginger as a natural anioxidant on testis apoptosis after treatment with gentamicin in rats.
  
  
  METHODS
  In order to study the recovery effects of ginger on testis apoptosis after treatment with gentamicin 40 adult Wistar male rats were selected and randomly divided into four groups. Normal salin control (group I) (n=10), gentamicin control (group II), ginger control (group III) and gentamicin + ginger (group IV) each 10 rats. There was observation of negative effect of Gentamicin on testis histology in rats.
  
  
  RESULTS
  The results revealed that there was a significant increase in apoptosis in group III when compared with other groups (P<0.05).However, ginger could decrease apoptosis in group IV that received 100mg/kg/rat of Ginger.
  
  
  CONCLUSIONS
  Regarding the results, it is recommended that administration of ginger with gentamicin might be beneficial in men who receive gentamicin to treat infections.
authors: Faculty of Veterinary Medicine, Islamic Azad University, Rasht Branch, Rasht, Iran.
authors: Afshin
authors: A
authors: Zahedi
authors: Fatemeh
authors: F
authors: Fathiazad
authors: Arash
authors: A
authors: Khaki
authors: Behnam
authors: B
authors: Ahmadnejad
keywords: Antioxidant; Apoptosis; Gentamicin; Ginger; Testis; Zingiber officinale