title: Mechanisms of intracellular defense and activity of free radical oxidation in rat myocardium in the dynamics of chronic fluorine intoxication.
abstract: The mechanisms of intracellular defense and activity of free radical oxidation in the myocardium were studied in the dynamics of chronic fluorine intoxication. At the early stages of fluorine intoxication (day 3-week 3), the concentrations of defense proteins HIF-1α, HSC73, and HOx-2 and activity of the main metabolic enzymes increased, which promoted maintenance of cardiomyocyte structure and function at the normal physiological level. At late stages of fluorine intoxication (weeks 6 and 9), metabolic changes in the myocardium attest to high strain of the adaptive mechanisms.
authors: Research Institute for Complex Problems of Hygiene and Occupational Diseases, Siberian Branch of the Russian Academy of Medical Sciences; Kuzbass State Pedagogical Academy, Novokuznetsk; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia. nyara_g@mail.ru.
authors: A G
authors: AG
authors: Zhukova
authors: D A
authors: DA
authors: Alekhina
authors: T G
authors: TG
authors: Sazontova
authors: Yu A
authors: YA
authors: Prokop'ev
authors: L G
authors: LG
authors: Gorokhova
authors: N V
authors: NV
authors: Stryapko
authors: N N
authors: NN
authors: Mikhailova
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000818:Animals; D002952:Citric Acid Cycle / Q000187:drug effects; D005461:Fluorine / Q000494:pharmacology / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D050883:HSC70 Heat-Shock Proteins / Q000032:analysis; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis; D006884:Hydroxybutyrate Dehydrogenase / Q000096:biosynthesis; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000096:biosynthesis; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis
chemical_list: D005609:Free Radicals; D050883:HSC70 Heat-Shock Proteins; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D011506:Proteins; D005461:Fluorine; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D006419:Heme Oxygenase (Decyclizing); C105245:heme oxygenase-2; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase