title: [Correlation of carbon monoxide with cell apoptosis in the penile tissue of aging rats].
abstract: OBJECTIVE
  To explore the pathogenesis of male sexual dysfunction by studying cell apoptosis and carbonate monoxide (CO) contents in the penile tissue of rats at different ages.
  
  
  METHODS
  We equally divided 24 male Wistar rats into an adult group (8 months old), an elderly group (16 months old) and an aged group (24 months old), and detected cell apoptosis by HE staining and TUNEL and CO levels in the penile tissues of different groups by modified dual-wavelength spectrophotometry.
  
  
  RESULTS
  Cell apoptosis increased with aging: 4.38 +/- 1.06 in the adult, 9.38 +/- 1.69 in the elderly and 18.50 +/- 1.60 in the aged group, while the CO content decreased with aging: 12.19 +/- 0.87 in the adult, 7.93 +/- 0.63 in the elderly and 5.68 +/- 0.62 in the aged group, both with statistically significant differences among the 3 groups (P < 0.05). The change of cell apoptosis showed a good negative correlation with that of the CO content (r = -0.889, P < 0.01).
  
  
  CONCLUSIONS
  Cell apoptosis and CO content change in the penile tissue of aging rats, and CO may participate in the development of ED by regulating cell apoptosis.
authors: Department of Histology and Embryology, College of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang 154007, China.
authors: Peng-Fei
authors: PF
authors: Cheng
authors: Department of Urology, The Second Affiliated Hospital, Jiamusi University, Jiamusi, Heilongjiang 154007, China.
authors: Wen-Bo
authors: WB
authors: Qin
authors: Department of Pathophysiology, College of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang 154007, China.
authors: Shu-Qiu
authors: SQ
authors: Wang
mesh_terms: D000375:Aging; D000818:Animals; D017209:Apoptosis; D002248:Carbon Monoxide / Q000378:metabolism*; D008297:Male; D010413:Penis / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002248:Carbon Monoxide