title: Catalytic conjugate addition of acyl anion equivalents promoted by fluorodesilylation.
abstract: The conjugate addition of acyl anion equivalents derived from 2-silyl-1,3-dithianes to α,β-unsaturated ketones and esters has been achieved using a substoichiometric amount of TBAF. High yields and short reaction times are observed for the addition of aryl-1,3-dithianes to a variety of cyclic and acyclic α,β-unsaturated carbonyl acceptors. Observation of the reactive anion by (13)C NMR spectroscopy and extension to an asymmetric variant is also presented.
authors: Roger Adams Laboratory, Department of Chemistry, University of Illinois , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors: Scott E
authors: SE
authors: Denmark
authors: Lindsey R
authors: LR
authors: Cullen