title: New hydrazones with pyrazolone structure: synthesis, characterization and biological evaluation.
abstract: OBJECTIVE
  To design new hydrazones with pyrazolone structure with improved biological properties.
  
  
  METHODS
  New hydrazones of antipyrine have been prepared by reaction of 4-aminophenazone (4-aminoantipyrine) with chloracetylchoride and hydrazine hydrate and then condensation with various aromatic aldehydes.
  
  
  RESULTS
  The synthesized compounds were screened for their antibacterial activity against Gram positive (Staphylococcus aureus ATCC 25923, Sarcinalutea ATCC 9341, Bacillus cereus ATCC 14579, Bacillus subtilis) and Gram negative bacterial strains (Escherichia coli ATCC 25922) and pathogenic yeasts (Candida albicans ATCC 10231, Candida sake, Candidaglabrata). Some of them were found to have good antibacterial and antifungal activity. The antioxidant activity of these compounds was also evaluated using the total antioxidant capacity test.
  
  
  CONCLUSIONS
  The chemical modulations performed on antipyrine structure have a good influence on the biological activity of the synthesized compounds.
authors: Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa"' - Iasi.
authors: Maria
authors: M
authors: Apotrosoaei
authors: Ioana
authors: I
authors: Vasincu
authors: Cristina
authors: C
authors: Tuchiluş
authors: Florentina
authors: F
authors: Lupascu
authors: Sandra
authors: S
authors: Constantin
authors: D
authors: D
authors: Lupaşcu
authors: Lenuta
authors: L
authors: Profire
mesh_terms: D000675:Ampyrone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002855:Chromatography, Thin Layer / Q000379:methods; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D047069:Pyrazolones / Q000138:chemical synthesis
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D000975:Antioxidants; D006835:Hydrazones; D047069:Pyrazolones; D000675:Ampyrone; C038362:pyrazolone