title: Cortical projection neurons: sprung from the same root.
abstract: Whether cortical projection neurons (CPNs) are generated by multipotent or fate-restricted progenitors is not completely understood. In this issue of Neuron, Guo et al. (2013) provide evidence that mouse Fezf2-expressing radial glial cells are multipotent progenitors that sequentially generate all major CPN subtypes and glia.
authors: Department of Neurobiology and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
authors: Wenqi
authors: W
authors: Han
authors: Nenad
authors: N
authors: Sestan
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000502:physiology*; D019579:Neocortex / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C412364:Zfp312 protein, mouse