title: [Surgical interventions in patients with mast cell activation disease. Aspects relevant for surgery using the example of a cholecystectomy].
abstract: BACKGROUND
  Systemic mast cell activation disease (MCAD) is characterized by an increased and unregulated release of mast cell mediators which can evoke a multifaceted clinical picture often resembling irritable bowel syndrome or fibromyalgia. Because of the considerable prevalence (~ 17 %) of MCAD surgeons are frequently unwittingly confronted with MCAD patients in whom unexpected intraoperative and postoperative complications may occur. Therefore, knowledge of the particular requirements is of relevance for surgical treatment of MCAD patients.
  
  
  OBJECTIVE
  The present paper outlines a concept of surgical treatment of MCAD patients based on the literature which is illustrated by a case report on emergency laparoscopic cholecystectomy.
  
  
  CONCLUSIONS
  Due to the high prevalence of MCAD in the general population it can be assumed that the frequency in the surgical patient population is similar. If a patient has MCAD, specific characteristics should be taken into account in the surgical procedure to avoid increased operative and complication risks resulting from MCAD.
authors: Abteilung für Allgemein- und Viszeralchirurgie, Haus St. Elisabeth, Gemeinschaftskrankenhaus Bonn, Bonn, Deutschland.
authors: B
authors: B
authors: Sido
authors: F L
authors: FL
authors: Dumoulin
authors: J
authors: J
authors: Homann
authors: H-J
authors: HJ
authors: Hertfelder
authors: M
authors: M
authors: Bollmann
authors: G J
authors: GJ
authors: Molderings
mesh_terms: D017081:Cholecystectomy, Laparoscopic; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004630:Emergencies; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D007431:Intraoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D007946:Leukemia, Mast-Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D008297:Male; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D055553:Prescription Drugs / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D055553:Prescription Drugs