title: Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: a case-control study.
abstract: Recent population-based genome wide association studies have revealed potential susceptibility loci of lung cancer at the region of chromosome 15q25.1 containing nicotinic acetylcholine receptor genes. The loci increasing lung cancer risk has been widely identified in Caucasians, but whether this association also exists in Asians and whether this association is a direct role or mediated via tobacco smoking indirectly has not been fully established. We conducted a case-control study comprising of 210 histologically confirmed lung cancer cases and 200 healthy controls to examine rs1051730 genotyping, a single nucleotide polymorphism receiving much attention recently, and its influence on lung cancer risk as well as nicotine dependence in a Chinese Han population. Our results showed that the heterozygous C/T genotype and minor allele T conferred a significant higher risk of lung cancer than the CC homozygotes and allele C (adjusted OR=2.25, 95% CI=1.04-4.89, P=0.040 and OR=2.18, 95% CI=1.02-4.67, P=0.045 respectively). However, no association between the smoking habit and the CHRNA3 rs1051730 polymorphism was observed in this study. The results suggested that the rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population. Additional studies in vitro and in vivo are warranted to further elucidate the impact of rs1051730 on lung cancer susceptibility.
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Jing-Hua
authors: JH
authors: Ren
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Min
authors: M
authors: Jin
authors: Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Wen-Shan
authors: WS
authors: He
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Cui-Wei
authors: CW
authors: Liu
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Shun
authors: S
authors: Jiang
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Wei-Hong
authors: WH
authors: Chen
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Kun-Yu
authors: KY
authors: Yang
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Gang
authors: G
authors: Wu
authors: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China. taozhangwh@aliyun.com.
authors: Tao
authors: T
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012907:Smoking
chemical_list: D011978:Receptors, Nicotinic