title: Influence of the vehicle on the penetration of particles into hair follicles.
abstract: Recently, it has been demonstrated that particulate substances penetrate preferentially into the hair follicles and that the penetration depth depends on the particle size. In the present study, the influence of the vehicle of the particulate substances on the penetration depth was investigated. Four different formulations (ethanolic suspension, aqueous suspension, ethanolic gel and aqueous gel) containing peptide-loaded particles of 1 µm in diameter were prepared and applied on porcine ear skin. After penetration, punch biopsies were taken and the penetration depths of the particles were investigated by laser scanning microscopy. The deepest penetration was achieved with the gel formulations demonstrating an influence of the vehicle on the penetration depth of particulate substances.
authors: Center of Experimental and Applied Cutaneous Physiology (CCP), Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany. alexa.patzelt@charite.de.
authors: Alexa
authors: A
authors: Patzelt
authors: Heike
authors: H
authors: Richter
authors: Lars
authors: L
authors: Dähne
authors: Peter
authors: P
authors: Walden
authors: Karl-Heinz
authors: KH
authors: Wiesmüller
authors: Ute
authors: U
authors: Wank
authors: Wolfram
authors: W
authors: Sterry
authors: Jürgen
authors: J
authors: Lademann