title: Ultra-wideband three-dimensional optoacoustic tomography.
abstract: Broadband optoacoustic waves generated by biological tissues excited with nanosecond laser pulses carry information corresponding to a wide range of geometrical scales. Typically, the frequency content present in the signals generated during optoacoustic imaging is much larger compared to the frequency band captured by common ultrasonic detectors, the latter typically acting as bandpass filters. To image optical absorption within structures ranging from entire organs to microvasculature in three dimensions, we implemented optoacoustic tomography with two ultrasound linear arrays featuring a center frequency of 6 and 24 MHz, respectively. In the present work, we show that complementary information on anatomical features could be retrieved and provide a better understanding on the localization of structures in the general anatomy by analyzing multi-bandwidth datasets acquired on a freshly excised kidney.
authors: Jérôme
authors: J
authors: Gateau
authors: Andrei
authors: A
authors: Chekkoury
authors: Vasilis
authors: V
authors: Ntziachristos
mesh_terms: D000818:Animals; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D007668:Kidney / Q000000981:diagnostic imaging*; D007834:Lasers; D008029:Lighting / Q000295:instrumentation*; D051379:Mice; D061088:Photoacoustic Techniques / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation