title: Use of anti-Aedes aegypti salivary extract antibody concentration to correlate risk of vector exposure and dengue transmission risk in Colombia.
abstract: Norte de Santander is a region in Colombia with a high incidence of dengue virus (DENV). In this study, we examined the serum concentration of anti-Aedes salivary gland extract (SGE) antibodies as a biomarker of DENV infection and transmission, and assessed the duration of anti-SGE antibody concentration after exposure to the vector ceased. We also determined whether SGE antibody concentration could differentiate between positive and negative DENV infected individuals and whether there are differences in exposure for each DENV serotype. We observed a significant decrease in the concentration of IgG antibodies at least 40 days after returning to an "Ae. aegypti-free" area. In addition, we found significantly higher anti-SGE IgG concentrations in DENV positive patients with some difference in exposure to mosquito bites among DENV serotypes. We conclude that the concentration of IgG antibodies against SGE is an accurate indicator of risk of dengue virus transmission and disease presence.
authors: Louisiana State University, Baton Rouge, Louisiana, United States of America ; Universidad de Pamplona, Pamplona, Colombia.
authors: Berlin
authors: B
authors: Londono-Renteria
authors: Jenny C
authors: JC
authors: Cardenas
authors: Lucio D
authors: LD
authors: Cardenas
authors: Rebecca C
authors: RC
authors: Christofferson
authors: Daniel M
authors: DM
authors: Chisenhall
authors: Dawn M
authors: DM
authors: Wesson
authors: Michael K
authors: MK
authors: McCracken
authors: Daisy
authors: D
authors: Carvajal
authors: Christopher N
authors: CN
authors: Mores
mesh_terms: D000328:Adult; D000330:Aedes / Q000737:chemistry* / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology*; D003105:Colombia / Q000453:epidemiology; D045424:Complex Mixtures / Q000737:chemistry* / Q000276:immunology; D003715:Dengue / Q000097:blood / Q000276:immunology / Q000635:transmission; D003716:Dengue Virus; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007299:Insect Bites and Stings / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D007303:Insect Vectors / Q000737:chemistry* / Q000276:immunology; D008297:Male; D012307:Risk Factors; D012469:Salivary Glands / Q000737:chemistry* / Q000276:immunology
chemical_list: D000906:Antibodies; D045424:Complex Mixtures; D007074:Immunoglobulin G