title: Device-detected atrial fibrillation and risk for stroke: an analysis of >10,000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices).
abstract: OBJECTIVE
  The aim of this study was to assess the association between maximum daily atrial fibrillation (AF) burden and risk of ischaemic stroke.
  
  
  BACKGROUND
  Cardiac implanted electronic devices (CIEDs) enhance detection of AF, providing a comprehensive measure of AF burden.
  
  
  METHODS
  A pooled analysis of individual patient data from five prospective studies was performed. Patients without permanent AF, previously implanted with CIEDs, were included if they had at least 3 months of follow-up. A total of 10 016 patients (median age 70 years) met these criteria. The risk of ischaemic stroke associated with pre-specified cut-off points of AF burden (5 min, 1, 6, 12, and 23 h, respectively) was assessed.
  
  
  RESULTS
  During a median follow-up of 24 months, 43% of 10 016 patients experienced at least 1 day with at least 5 min of AF burden and for them the median time to the maximum AF burden was 6 months (inter-quartile range: 1.3-14). A Cox regression analysis adjusted for the CHADS2 score and anticoagulants at baseline demonstrated that AF burden was an independent predictor of ischaemic stroke. Among the thresholds of AF burden that we evaluated, 1 h was associated with the highest hazard ratio (HR) for ischaemic stroke, i.e. 2.11 (95% CI: 1.22-3.64, P = 0.008).
  
  
  CONCLUSIONS
  Device-detected AF burden is associated with an increased risk of ischaemic stroke in a relatively unselected population of CIEDs patients. This finding may add to the basis for timely and clinically appropriate decision-making on anticoagulation treatment.
authors: Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, University of Bologna, S.Orsola-Malpighi University Hospital, Via Massarenti 9, Bologna 40138, Italy.
authors: Giuseppe
authors: G
authors: Boriani
authors: Taya V
authors: TV
authors: Glotzer
authors: Massimo
authors: M
authors: Santini
authors: Teena M
authors: TM
authors: West
authors: Mirko
authors: M
authors: De Melis
authors: Milan
authors: M
authors: Sepsi
authors: Maurizio
authors: M
authors: Gasparini
authors: Thorsten
authors: T
authors: Lewalter
authors: John A
authors: JA
authors: Camm
authors: Daniel E
authors: DE
authors: Singer
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000628:therapy*; D017281:Cost of Illness; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000517:prevention & control; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants
keywords: Anticoagulation; Atrial fibrillation; Implantable defibrillator; Pacemaker; Stroke