title: Clinicopathological characteristics of chordoma: an institutional experience and a review of the literature.
abstract: OBJECTIVE
  To study the clinicopathologic characteristics of chordomas from a single institution.
  
  
  METHODS
  This study is a retrospective analysis of 18 cases of chordomas diagnosed over a period of 5-years at Sher-i-Kashmir Institute of Medical Sciences, Srinagar, from 2006 to 2010.
  
  
  RESULTS
  The overall mean age of the patients was 46.72 years. Males outnumbered females. Sacrum was the commonest site involved. Histopathologically, the majority of cases were conventional chordoma with four cases of chondroid variety. There was a single case of dedifferentiated chordoma that presented with bone metastasis. Most patients did well after surgery and radiotherapy. One patient had a local recurrence and one patient with dedifferentiated variant died on follow-up.
  
  
  CONCLUSIONS
  Though locally aggressive, chordomas are effectively treated with resection and postoperative radiotherapy.
authors: Skims, Department of Pathology, Srinagar, Kashmir, India.
authors: Rumana
authors: R
authors: Makhdoomi
authors: Altaf
authors: A
authors: Ramzan
authors: Nayil
authors: N
authors: Khursheed
authors: Salma
authors: S
authors: Bhat
authors: Khalil
authors: K
authors: Baba
authors: Rasool
authors: R
authors: Mohsin
authors: Mubeen
authors: M
authors: Basharat
authors: Bhat
authors: B
authors: Yameen
authors: Rayees
authors: R
authors: Ahmad
authors: Lone
authors: L
authors: Iqbal
authors: Mohammad
authors: M
authors: Maqbool
authors: Hakeem
authors: H
authors: Ajaz
authors: Mustafa
authors: M
authors: Farhat
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery*; D002817:Chordoma / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007194:India / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012447:Sacrum / Q000601:surgery; D012737:Sex Factors; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult