title: Effects of an ethinyl estradiol/gestodene transdermal contraceptive patch on the endometrium: a single-center, uncontrolled study.
abstract: OBJECTIVE
  This study aims to investigate the effect of a transdermal contraceptive patch containing ethinyl estradiol and gestodene on endometrial proliferation over 1 year.
  
  
  METHODS
  In this open-label, uncontrolled, Phase IIb study, women (aged 18-35 years) used the patch for 13 cycles of 28 days. The primary variable was histologic endometrial effects at cycle 13. Secondary objectives included contraceptive efficacy and safety.
  
  
  RESULTS
  Overall, 89 women were treated. At all visits, endometrial biopsies were devoid of any abnormalities. One woman became pregnant. The patch was well tolerated, with no safety concerns.
  
  
  CONCLUSIONS
  The ethinyl estradiol and gestodene patch had an endometrial effect consistent with suppression of endometrial proliferation in most patients. No endometrial abnormalities or other concerns were reported; compliance was good.
authors: Bayer Pharma AG, 13353 Berlin, Germany. martin.merz@bayer.com.
authors: Martin
authors: M
authors: Merz
authors: Julia
authors: J
authors: Grunert
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004717:Endometrium / Q000187:drug effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage* / Q000494:pharmacology; D011372:Progestins / Q000008:administration & dosage* / Q000494:pharmacology; D057968:Transdermal Patch; D016896:Treatment Outcome; D014621:Vagina / Q000187:drug effects; D055815:Young Adult
chemical_list: D003271:Contraceptive Agents, Female; D009652:Norpregnenes; D011372:Progestins; C033273:Gestodene; D004997:Ethinyl Estradiol