title: [Invasive streptococcal (group A) infection of soft tissues in a Moscow surgical hospital].
abstract: OBJECTIVE
  To study features and risk factors of soft tissue's invasive streptococcal infection in surgical unit's patients: a) emm-types of the most often recovered streptococcus; b) human immune response for streptococcal antigens (streptolysin-O and the group A carbohydrate antigen); c) main patient's conditions that complicate the course of soft tissue's streptococcal infection.
  
  
  METHODS
  101 surgical unit's patients with soft tissue's infection, which group A streptococcal (GAS) nature, were examined. Emm-types were determined by comparison ofemm gene sequenced part with data of CDC Streptococcus Laboratory. ASO and specific anti-group-carbohydrate IgM were measured with photometry and ELISA4 accordingly. Patient's personal data were analyzed by standard statistical programs.
  
  
  RESULTS
  Among 34 emm-types of all streptococcal isolates emm28 and emm64 were registered only in invasive infection. Emm-types 1, 49, 60, 66, 77, 84, 88 were most often. Among 23 sera from invasive GAS-infection's patients, 15(65%) were ASO-negative, 6 (26%) were ASO-low-positive, and 2 (8%) were positive, but negative for the anti-group-A-carbohydrate IgM.
  
  
  CONCLUSIONS
  Lower levels of the humoral immune response as well as risk factors such as trauma, alcoholism, diabetes, chronic venous insufficiency contributed to development of severe forms of GAS-infection. The main streptococcal emm-types for soft tissue's invasive GAS infection in one of Moscow surgical unit's patients in 2008-2011 were registered.
authors: N I
authors: NI
authors: Briko
authors: E V
authors: EV
authors: Glushkova
authors: N F
authors: NF
authors: Dmitrieva
authors: D A
authors: DA
authors: Kleĭmenov
authors: K V
authors: KV
authors: Lipatov
authors: A S
authors: AS
authors: Eshchina
authors: Iu M
authors: IuM
authors: Timofeev
authors: M A
authors: MA
authors: Mirskaia
authors: O V
authors: OV
authors: Vvedenskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000453:epidemiology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000302:isolation & purification*; D013531:Surgicenters; D055815:Young Adult