title: [Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population].
abstract: OBJECTIVE
  To explore the association between CYP11B2 gene polymorphism and essential hypertension, blood pressure level in Chinese Han population by meta-analysis.
  
  
  METHODS
  After searching database, the research quality was quantified according to NOS. Genetic model, heterogeneity, publication bias, overall OR/standardized mean difference (SMD) and 95%CI were explored by Stata, 19 studies including 9249 subjects were included in this meta-analysis.
  
  
  RESULTS
  Compared to control group, OR(95%CI) of CC vs. TT, CT vs. TT, CC vs. CT in essential hypertensive patients were 1.022(95%CI: 0.879-1.190), 1.108 (95%CI: 0.951-1.291), 1.050(95%CI:0.995-1.109), respectively; SMD (95%CI) was 0.315 (0.066-0.565, P < 0.05) for systolic pressure derived CC vs. TT, and 0.088 (0.014-0.162, P < 0.05) for CT vs.
  Individuals with -344C CYP11B2 allele are at higher risk of increased systolic blood pressure, but there is no evidence showing association between CYP11B2 polymorphism and susceptibility of essential hypertension in Chinese Han population.
authors: Department of Epidemiology and Health Statistics, Public Health College of Fujian Medical University, Fuzhou 350108, China.
authors: Wen-jing
authors: WJ
authors: Ye
authors: Email: zling2006@163.com.
authors: Ling
authors: L
authors: Zheng
authors: Zheng-hua
authors: ZH
authors: Wang
authors: Huan-huan
authors: HH
authors: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D000075222:Essential Hypertension; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019405:Cytochrome P-450 CYP11B2