title: In vitro Cytotoxic Activity of Four Plants Used in Persian Traditional Medicine.
abstract: OBJECTIVE
  The aim of this study was to investigate in vitro cytotoxic activity of four methanolic crude plant extracts against panel cell lines.
  
  
  METHODS
  Methanolic extracts were tested for their possible antitumor activity and cytotoxicity using the 3-(4,5-dimetylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay on six cancer cell lines; non-Hodgkin's B-cell lymphoma (Raji), human leukemic monocyte lymphoma (U937), human acute myelocytic leukemia (KG-1A), human breast carcinoma (MCF-7 cells), human Prostate Cancer (PC3) and mouse fibrosarcoma (WEHI-164) cell lines and one normal cell line; Human Umbilical Vein Endothelial Cells (HUVEC).
  
  
  RESULTS
  All species showed dose dependent inhibition of cell proliferation. IC50 values ranging from 25.66±1.2 to 205.11±1.3 μg/ml. The highest cytotoxic activity Chelidonium majus L> Ferulago Angulata DC> Echinophora platyloba DC> Salvia officinalis L, respectively.
  
  
  CONCLUSIONS
  all extracts demonstrate promising cytotoxicity activity as a natural resource for future bio-guided fractionation and isolation of potential antitumor agents.
authors: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Fateme
authors: F
authors: Zare Shahneh
authors: Behzad
authors: B
authors: Baradaran
authors: Mona
authors: M
authors: Orangi
authors: Fatemeh
authors: F
authors: Zamani
keywords: Anti-tumor; Apoptosis; Cancer; Cytotoxic