title: Multiple organ dysfunction caused by parathyroid adenoma-induced primary hyperparathyroidism.
abstract: We present a 27-year-old male with multiple organ dysfunction caused by parathyroid adenoma-induced primary hyperparathyroidism (PHPT). Initially, the patient experienced a sudden onset of gastrointestinal symptoms, polyuria, polydipsia, bone pain, renal dysfunction, nephrolithiasis, and acute pancreatitis, symptoms associated with hypercalcemia. Biochemical findings suggested PHPT. Renal biopsy showed an acute tubular injury and massive calcium deposits in the tubular epithelial cells and tubular lumina. Moreover, neck ultrasonography suggested the possibility of a parathyroid tumor. We excised his right parathyroid gland. Histopathological analysis revealed features of a parathyroid adenoma. Post-operatively this patient had normal serum calcium concentration, but was renally insufficient. A recent repeat biopsy showed chronic renal tubular injury. Our findings illustrate the complications of various systems that can occur in patients with PHPT caused by a parathyroid adenoma.
authors: Treatment Center for Kidney Diseases, No. 281 Hospital of Chinese People's Liberation Army, 4 Xi hai tan Road, Beidaihe District, Qinhuangdao 066100, P. R, China.
authors: Q-Y
authors: QY
authors: Fu
authors: L
authors: L
authors: Ma
authors: Z-B
authors: ZB
authors: Yang
authors: T
authors: T
authors: Pao
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000209:etiology*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed