title: Epithelial wound healing after cataract surgery comparing two different topical fluoroquinolones.
abstract: OBJECTIVE
  To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery.
  
  
  METHODS
  In this prospective, evaluator-masked, randomized clinical trial, 59 eyes of 50 patients who underwent cataract surgery were enrolled. Patients were randomized to receive moxifloxacin 0.5% (n=32 eyes) or levofloxacin 0.5% (n=27 eyes). All patients instilled moxifloxacin or levofloxain four times daily for 1 week prior to surgery and 2 weeks after surgery. The epithelial wound healing status in the corneal incision site was scanned with a raster scan mode of fourier-domain optical coherence tomography (FD-OCT). The number of eyes showing epithelial defect images and average number of corneal epithelial defect cuts per eye were compared between groups. All patients were evaluated on postoperative days 1, 2, 3, and 10.
  
  
  RESULTS
  On postoperative days 1, 2, and 3, the number of eyes showing epithelial defects in FD-OCT was not statistically different (all p>0.05). The average number of corneal epithelial defect cuts was also not statistically different between the two groups (all p>0.05). No eyes showed epithelial defects on postoperative day 10 in either group.
  
  
  CONCLUSIONS
  There were no differences on epithelial wound healing comparing these two different fluoroquinolones at the incision site of cataract surgery.
authors: Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. eungkkim@yuhs.ac.
authors: Kyung Eun
authors: KE
authors: Han
authors: Woo Suk
authors: WS
authors: Chung
authors: Tae-im
authors: TI
authors: Kim
authors: Sekyung
authors: S
authors: Kim
authors: Terry
authors: T
authors: Kim
authors: Eung Kweon
authors: EK
authors: Kim
mesh_terms: D000368:Aged; D001372:Aza Compounds / Q000627:therapeutic use; D002387:Cataract Extraction; D003315:Cornea / Q000187:drug effects / Q000601:surgery*; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D064704:Levofloxacin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D011804:Quinolines / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D064704:Levofloxacin; D000077266:Moxifloxacin
keywords: Levofloxacin; cataract surgery; epithelial wound healing; moxifloxacin