title: Relationships between body fat accumulation, aerobic capacity and insulin resistance in Japanese participants.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  This study evaluated the relationships between body fat accumulation, aerobic capacity and insulin resistance (HOMA-IR) in 61 Japanese participants.
  
  
  METHODS
  The participants were middle-aged to elderly (age: 33-73; BMI: 21.6-38.5). Body fat mass (FM) was evaluated by hydrostatic weighing. Computed tomography was used to evaluate visceral and subcutaneous fat areas (VFA and SFA), liver to spleen ratio (L/S), and low-density muscle area (LDMA). To assess aerobic capacity, VO2 at the lactate threshold (VO2@LT) and VO2 peak were measured using a bicycle ergometer.
  
  
  RESULTS
  FM, VFA, SFA, LDMA and L/S significantly correlated with HOMA-IR, but VO2@LT and VO2 peak did not. Analysis of covariance after adjustment for VFA or other body fat distribution and aerobic capacity showed that HOMA-IR had a significant linear trend across the tertile groups of L/S. However, for FM, VFA, SFA, LDMA and VO2@LT or VO2 peak, no significant trend was observed between the tertiles and insulin resistance.
  
  
  CONCLUSIONS
  Ectopic fat deposition in the liver may influence insulin resistance independently of other body fat accumulation and aerobic capacity in Japanese participants.
authors: Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors: Eiichi
authors: E
authors: Yoshimura
authors: Faculty of Nutrition Sciences, Nakamura Gakuen University, Fukuoka, Japan.
authors: Hideaki
authors: H
authors: Kumahara
authors: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
authors: Takuro
authors: T
authors: Tobina
authors: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
authors: Makoto
authors: M
authors: Ayabe
authors: Fukuoka Safety Center, Fukuoka, Japan.
authors: Sakiko
authors: S
authors: Matono
authors: Faculty of Medicine, Saga University, Saga, Japan.
authors: Keizo
authors: K
authors: Anzai
authors: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
authors: Yasuki
authors: Y
authors: Higaki
authors: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
authors: Akira
authors: A
authors: Kiyonaga
authors: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan. Electronic address:htanaka@fukuoka-u.ac.jp.
authors: Hiroaki
authors: H
authors: Tanaka