title: Synthesis and insecticidal evaluation of novel anthranilic diamides containing N-substitued nitrophenylpyrazole.
abstract: To cope with developing pest resistance and ecological problems associated with conventional insecticides and to search for potent insecticides targeting at ryanodine receptor (RyR), a series of novel anthranilic diamides containing N-substitued nitrophenylpyrazole were designed and synthesized. The insecticidal activities of target compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated in our greenhouse by bio-assay tests and the relative structure-activity relationships were briefly discussed. Most compounds exhibited moderate to high activities, in which G₇ and K₅ showed high activity against oriental armyworm and K₂ and K₄ against diamondback moth even better than the control-chlorantraniliprole. The calcium imaging technique was used to investigate the effects of several typical title compounds on the [Ca(2+)](i), especially the effects of G₇ on the intracellular calcium ion concentration ([Ca(2+)](i)) in neurons, which indicated that some title compounds were potent activators of the RyR.
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Xiulan
authors: X
authors: Zhang
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Yuxin
authors: Y
authors: Li
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Jinlong
authors: J
authors: Ma
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Hongwei
authors: H
authors: Zhu
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Baolei
authors: B
authors: Wang
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Mingzhen
authors: M
authors: Mao
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Lixia
authors: L
authors: Xiong
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors: Yongqiang
authors: Y
authors: Li
authors: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China. Electronic address: nkzml@vip.163.com.
authors: Zhengming
authors: Z
authors: Li
mesh_terms: D003958:Diamide / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D011720:Pyrazoles; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D003958:Diamide
keywords: Calcium channel; Insecticidal activity; N-substitued nitrophenylpyrazole