title: Sensitive and selective electrochemical determination of quinoxaline-2-carboxylic acid based on bilayer of novel poly(pyrrole) functional composite using one-step electro-polymerization and molecularly imprinted poly(o-phenylenediamine).
abstract: A facile and efficient molecularly imprinted polymer (MIP) recognition element of electrochemical sensor was fabricated by directly electro-polymerizing monomer o-phenylenediamine (oPD) in the presence of template quinoxaline-2-carboxylic acid (QCA), based on one-step controllable electrochemical modification of poly(pyrrole)-graphene oxide-binuclear phthalocyanine cobalt (II) sulphonate (PPY-GO-BiCoPc) functional composite on glassy carbon electrode (GCE). The MIP film coated on PPY-GO-BiCoPc functional composite decorated GCE (MIP/PPY-GO-BiCoPc/GCE) was presented for the first time. The synergistic effect and electro-catalytic activity toward QCA redox of PPY-GO-BiCoPc functional composite were discussed using various contrast tests. Also, the effect of experimental variables on the current response such as, electro-polymerization cycles, template/monomer ratio, elution condition for template removal, pH of the supporting electrolyte and accumulation time, were investigated in detail. Under the optimized conditions, the proposed MIP sensor possessed a fast rebinding dynamics and an excellent recognition capacity to QCA, while the anodic current response of square wave voltammetry (SWV) was well-proportional to the concentration of QCA in the range of 1.0×10(-8)-1.0×10(-4) and 1.0×10(-4)-5.0×10(-4) mol L(-1) with a low detection limit of 2.1 nmol L(-1). The established sensor was applied successfully to determine QCA in commercial pork and chicken muscle samples with acceptable recoveries (91.6-98.2%) and satisfactory precision (1.9-3.5% of SD), demonstrating a promising feature for applying the MIP sensor to the measurement of QCA in real samples.
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Yukun
authors: Y
authors: Yang
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Guozhen
authors: G
authors: Fang
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Xiaomin
authors: X
authors: Wang
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Mingfei
authors: M
authors: Pan
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Hailong
authors: H
authors: Qian
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
authors: Huilin
authors: H
authors: Liu
authors: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address: s.wang@tust.edu.cn.
authors: Shuo
authors: S
authors: Wang
mesh_terms: D000818:Animals; D002645:Chickens; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D054833:Isoindoles; D008460:Meat / Q000032:analysis; D054802:Molecular Imprinting; D010655:Phenylenediamines / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D011810:Quinoxalines / Q000032:analysis*; D013552:Swine
chemical_list: D007211:Indoles; D054833:Isoindoles; D010655:Phenylenediamines; D011108:Polymers; D011758:Pyrroles; D011810:Quinoxalines; C530487:poly(o-phenylenediamine); C067635:polypyrrole; D006108:Graphite; C042218:quinoxaline-2-carboxylic acid; C013647:phthalocyanine
keywords: Binuclear phthalocyanine cobalt(II) sulphonate; Electrochemical sensor; Graphene oxide; Molecularly imprinted poly(o-phenylenediamine); Poly(pyrrole); Quinoxaline-2-carboxylic acid