title: Self-assembled stimuli-responsive polyrotaxane core-shell particles.
abstract: Thermodynamically assembled core-shell nanocarriers are potential candidates for drug delivery applications due to their submicrometer size and the ability to load drugs into their hydrophobic core. Herein, we describe the formation of core-shell particles that consist of noncovalent polymers, that is, polyrotaxanes (PRXs), that form an α-cyclodextrin (αCD) core surrounded by a corona of low-fouling poly(ethylene glycol) (PEG). The PRX core-shell particles are able to sequester small organic molecules, such as pyrene and calcein, releasing these small molecules during degradation. The small, cellular peptide, glutathione, was used to degrade the particles through the reductive cleavage of disulfide bonds that stabilize the individual PRX polymers. Cleavage of a single bond allows for the degradation of the supramolecular-polymer, making these PRX core-shell particles highly responsive. Furthermore, these particles demonstrate negligible cytotoxicity in mammalian cells, making them promising carriers for future drug delivery research.
authors: Department of Chemical and Biomolecular Engineering, The University of Melbourne , Victoria 3010, Australia.
authors: Blaise L
authors: BL
authors: Tardy
authors: Henk H
authors: HH
authors: Dam
authors: Marloes M J
authors: MM
authors: Kamphuis
authors: Joseph J
authors: JJ
authors: Richardson
authors: Frank
authors: F
authors: Caruso
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003505:Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry* / Q000494:pharmacology; D043862:Rotaxanes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D043862:Rotaxanes; C475673:polyrotaxane; D020442:Poloxamer