title: [Idiopathic retroperitoneal fibrosis: a multicentric retrospective study of 30 French cases and follow-up of the renal function].
abstract: OBJECTIVE
  Idiopathic retroperitoneal fibrosis (IRF) is an inflammatory disorder, affecting the aorta and the surrounding vessels and tissues. The prognosis is mainly driven by the risks of chronic kidney disease and relapse. Our aim was to assess the prevalence of chronic kidney disease at follow-up.
  
  
  METHODS
  We retrospectively reviewed the medical records of patients diagnosed for IRF in Seine-Saint-Denis (France) between 1987 and 2011. We collected informations about presentation, radiologic findings and follow-up. Diagnosis of IRF was confirmed when all the following criteria were met: infiltration of the infrarenal aorta or iliac vessels, absence of aneurysmal dilation, lack of clinical suspicion of malignancy.
  
  
  RESULTS
  Thirty patients were identified, with a male/female ratio of 4.9. Mean age was 55±13 years old. The mean creatinine clearance was 66 mL/min/1.73 m(2) and the mean CRP was 45±36 mg/L. In 24 (80%) patients, the location of IRF was periaortic and periiliac. Eleven patients (37%) underwent a diagnostic biopsy, and 14 (47%) required an ureteral procedure. A mean follow-up of 63 months was available for 29 patients: 69% relapsed, 7 developed chronic renal disease (24%), and one died of urinary sepsis. Older age (P=0.023), diabetes (P=0.007), and initial renal insufficiency (P=0.05) were associated with a risk of chronic renal insufficiency.
  
  
  CONCLUSIONS
  The high frequency of relapses and chronic renal disease emphasizes the need of close follow-up in patients diagnosed with IRF.
authors: Service de médecine interne, hôpital Avicenne, Assistance publique-Hôpitaux de Paris (AP-HP), UPRES EA3509, laboratoire de recherche clinique et thérapeutique, université Paris-13, Sorbonne Paris-Cité, 93000 Bobigny, France. Electronic address: gs.irene@gmail.com.
authors: I
authors: I
authors: Gallais Sérézal
authors: Service de médecine interne, hôpital Avicenne, Assistance publique-Hôpitaux de Paris (AP-HP), UPRES EA3509, laboratoire de recherche clinique et thérapeutique, université Paris-13, Sorbonne Paris-Cité, 93000 Bobigny, France.
authors: S
authors: S
authors: Le Jeune
authors: Service de néphrologie, hôpital André-Grégoire, 93100 Montreuil, France.
authors: X
authors: X
authors: Belenfant
authors: Service de médecine interne, hôpital Robert-Ballanger, 93600 Aulnay-sous-Bois, France.
authors: R
authors: R
authors: Bakir
authors: Service de médecine interne, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris (AP-HP), université Paris-13, Sorbonne Paris-Cité, 93140 Bondy, France.
authors: O
authors: O
authors: Fain
authors: Service de médecine interne, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris (AP-HP), université Paris-13, Sorbonne Paris-Cité, 93140 Bondy, France.
authors: A
authors: A
authors: Mekinian
authors: Hôpital Delafontaine, 93200 Saint-Denis, France.
authors: N
authors: N
authors: Gambier
authors: Service de médecine interne, hôpital Cochin, Assistance publique-Hôpitaux de Paris (AP-HP), 75005 Paris, France.
authors: L
authors: L
authors: Mouthon
authors: Service de médecine interne, hôpital Tenon, Assistance publique-Hôpitaux de Paris (AP-HP), 75020 Paris, France.
authors: O
authors: O
authors: Steichen
authors: Service de médecine interne, hôpital Cochin, Assistance publique-Hôpitaux de Paris (AP-HP), 75005 Paris, France.
authors: P
authors: P
authors: Blanche
authors: Service de médecine interne, hôpital Avicenne, Assistance publique-Hôpitaux de Paris (AP-HP), UPRES EA3509, laboratoire de recherche clinique et thérapeutique, université Paris-13, Sorbonne Paris-Cité, 93000 Bobigny, France.
authors: J-J
authors: JJ
authors: Mourad
authors: Service de médecine interne, hôpital Avicenne, Assistance publique-Hôpitaux de Paris (AP-HP), UPRES EA3509, laboratoire de recherche clinique et thérapeutique, université Paris-13, Sorbonne Paris-Cité, 93000 Bobigny, France.
authors: R
authors: R
authors: Dhôte
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012185:Retroperitoneal Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies
keywords: Acute renal insufficiency; Chronic renal insufficiency; Fibrose rétropéritonéale; Insuffisance rénale aiguë; Insuffisance rénale chronique; Retroperitoneal fibrosis