title: Ischemic preconditioning for cell-based therapy and tissue engineering.
abstract: Cell- and tissue-based therapies are innovative strategies to repair and regenerate injured hearts. Despite major advances achieved in optimizing these strategies in terms of cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. The non-genetic approach of ischemic/hypoxic preconditioning to enhance cell- and tissue-based therapies has received much attention in recent years due to its non-invasive drug-free application. Here we discuss the current development of hypoxic/ischemic preconditioning to enhance stem cell-based cardiac repair and regeneration.
authors: Department of Cardiovascular Science, University of Sheffield, United Kingdom.
authors: Sarah T
authors: ST
authors: Hsiao
authors: Ear Science Institute Australia and Ear Sciences Centre, School of Surgery, University of Western Australia, Nedlands, Western Australia, Australia.
authors: Rodney J
authors: RJ
authors: Dilley
authors: Centre for Eye Research Australia and Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Department of Ophthalmology, University of Melbourne, East Melbourne, Victoria, Australia; Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia; O'Brien Institute, Fitzroy, Victoria, Australia.
authors: Gregory J
authors: GJ
authors: Dusting
authors: Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia; O'Brien Institute, Fitzroy, Victoria, Australia. Electronic address: maxlim@unimelb.edu.au.
authors: Shiang Y
authors: SY
authors: Lim
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D023822:Tissue Engineering; D016896:Treatment Outcome
keywords: Cell therapy; Hypoxic preconditioning; Ischemic preconditioning; Paracrine; Stem cell; Tissue engineering