title: Obesity is associated with higher risk of prostate cancer detection in a biopsy population in Korea.
abstract: OBJECTIVE
  To evaluate the impact of obesity on prostate cancer detection, as measured by the body mass index (BMI) in a Korean biopsy population.
  
  
  METHODS
  We retrospectively reviewed the records of 1213 men who underwent transrectal ultrasonography-guided prostate biopsy at our institution. Biopsy outcomes were analysed with respect to various variables, including patient age, prostate-specific antigen (PSA), prostate volume, digital rectal examination (DRE) findings and obesity, defined as BMI ≥25 kg/m(2) , an Asian BMI category.
  
  
  RESULTS
  Among 1213 men, 408 (33.6%) were obese and 344 (28.4%) had a positive biopsy. Obese men were younger (65.5 vs 67.1 years, P = 0.003), had a larger prostate (49.2 vs 42.9 mL, P < 0.001) and were less likely to have any abnormality on DRE (8.1 vs 15.9% P < 0.001) than non-obese men. In the multivariate analysis, obesity was significantly associated with a higher risk of prostate cancer detection in men undergoing biopsy (odds ratio [OR] = 1.446, P = 0.024). In addition, obesity was significantly associated with a higher rate of biopsy-detected high grade (Gleason score ≥4 + 3) disease, and this association remained after multivariate adjustment (OR = 1.498, P = 0.039).
  
  
  CONCLUSIONS
  Obese men were younger, had a larger prostate, and had less tendency to have an abnormality on DRE than non-obese men. Obesity was associated with a higher risk of prostate cancer detection as an independent factor, including high grade prostate cancer in a Korean biopsy population.
authors: Department of Urology, Aerospace Medical Center, Cheongwon-Gun, Choongchungbuk-Do, Korea.
authors: Juhyun
authors: J
authors: Park
authors: Sung Yong
authors: SY
authors: Cho
authors: Seung Bae
authors: SB
authors: Lee
authors: Hwancheol
authors: H
authors: Son
authors: Hyeon
authors: H
authors: Jeong
mesh_terms: D000368:Aged; D001706:Biopsy; D015992:Body Mass Index; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
keywords: biopsy; body mass index; obesity; prostate; prostatic neoplasms