title: Study of renal function in living kidney donors: estimated or measured glomerular filtration.
abstract: BACKGROUND
  In living kidney donations the accuracy of renal function is fundamental, especially for potential donors who have limited renal function (creatinine clearance levels [CCr] <90 mL/m/1.73 m(2)), are >50 years old, and who have cardiovascular risk factors that might favor the development of kidney diseases.
  
  
  OBJECTIVE
  To compare the direct measured glomerular filtration (mGFR) using 51Cr-EDTA and the estimations based on creatinine (estimated glomerular filtration rate [eGFR]): CCr with 24-hour urine, and estimated using Cockroft-Gault (adjusted using body surface area, Mosteller formula), modification of diet in renal disease-4 (MDRD-4), MDRD-6, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) to determine the usefulness of different methods to evaluate the kidney function.
  
  
  METHODS
  The kidney function evaluation was performed for 37 potential kidney donors using the 51Cr-EDTA method. The GFR obtained through the 51Cr-EDTA was compared with the CCr values in 24-hour urine and eGFR based on creatinine (Cockcroft-Gault, MDRD-4, MDRD-6, and CKD-EPI).
  
  
  RESULTS
  Using the Bland Altman graph, the most dispersed results were obtained with the eGFR using CCr in 24-hour urine and CKD-EPI. By means of Passing and Bablok, MDRD-4 and MDRD-6 showed the highest approximation to the reference method proposed to be substituted, whereas CCr showed a high dispersion.
  
  
  CONCLUSIONS
  The eGFR using MDRD-4 and MDRD-6 formulas revealed the best adjustment to the measure by 51Cr-EDTA. This might represent the best option if a direct eGFR measure is not available.
authors: Service of Nephrology, Virgen del Rocío University Hospital, Seville, Spain. Electronic address: lobama85@hotmail.com.
authors: L Ballestero
authors: LB
authors: Macías
authors: M Suñer
authors: MS
authors: Poblet
authors: R Iglesias
authors: RI
authors: Jerez
authors: F M Gonzalez
authors: FM
authors: Roncero
authors: G Bernal
authors: GB
authors: Blanco
authors: P Pereira
authors: PP
authors: Palomo
authors: M A Gentil
authors: MA
authors: Govantes
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000097:blood; D046148:Donor Selection; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009392:Nephrectomy; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals
chemical_list: D015415:Biomarkers; D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; D004492:Edetic Acid; D003404:Creatinine