title: Uric acid levels in obstructive sleep apnea patients with atrial fibrillation.
abstract: OBJECTIVE
  The objective of this observational study was to determine whether there is an association between atrial fibrillation (AF) and uric acid and to identify the risk markers for AF in obstructive sleep apnea (OSA).
  
  
  METHODS
  Consecutive patients with newly diagnosed OSA were screened at baseline. The final study population consisted of 516 patients. One hundred and eight patients had AF. Demographic, clinical, laboratory, and echocardiographic characteristics were carefully recorded. Logistic regression was used for the multivariate analysis of independent risk factors.
  
  
  RESULTS
  Uric acid, triglyceride, high-density lipoprotein, C-reactive protein (CRP), left atrial diameter, interventricular septum thickness, apnea hypopnea index, and Epworth sleepiness scale were significantly higher in OSA patients with AF than in those without AF (p <0.05). Among these patients, multiple logistic analyses indicated the independent risk factors for AF occurrence in the OSA subjects included serum uric acid level, left atrial diameter, percentage of time with SaO2 <90%, CRP. The diagnosis analysis showed that higher uric acid, CRP, left atrial diameter and percentage of time with SaO2 <90% had a significant ability to reflect the presence of AF occurrence.
  
  
  CONCLUSIONS
  The novel finding of this study is that the occurrence of AF in OSA patients is strongly related to serum uric acid level, left atrial diameter, percentage of time with SaO2 <90% and CRP level. These results may be helpful for monitoring AF occurrence in OSA patients.
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China. Electronic address: ggwanyufeng@163.com.
authors: Yu-feng
authors: YF
authors: Wan
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Yu-long
authors: YL
authors: Zheng
authors: Department of Clinical Laboratory, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Hong-yan
authors: HY
authors: Niu
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Chuan-qin
authors: CQ
authors: Xu
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Yuan-qiang
authors: YQ
authors: He
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Yi
authors: Y
authors: Wang
authors: Department of Respiratory Diseases, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Jian-hui
authors: JH
authors: Chen
authors: Department of Nephrology, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
authors: Dong-hui
authors: DH
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Atrial fibrillation; Obstructive sleep apnea; Risk factors; Uric acid