title: Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells.
abstract: Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8+T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.
authors: Department of Radiation and Cellular Oncology; The Ludwig Center for Metastasis Research; University of Chicago; Chicago, IL USA.
authors: Hua
authors: H
authors: Liang
authors: Liufu
authors: L
authors: Deng
authors: Byron
authors: B
authors: Burnette
authors: Ralph R
authors: RR
authors: Weichselbaum
authors: Yang-Xin
authors: YX
authors: Fu
keywords: PD-L1; T cells; equilibrium; radiation; tumor recurrence