title: [Nervous regulation of thyroid function].
abstract: Review examines the autonomic regulation of thyroid function. Review examines the issues of autonomic regulation of the thyroid gland. Activation of the central a-adrenergic mechanisms increases the release of thyroid-stimulating hormone of pituitary mainly due to the stimulation of its secretion. Dopamine inhibits the secretion of this hormone, acting on D2-receptors tireotropotsitov. Acetylcholine and other cholinomimetics inhibit the functional activity of thyrocitebl with the participation of muscarinic receptors. Along the sympathetic and parasympathetic special attention paid to the role of the serotonergic division of vegetative system. Serotonin can inhibit the secretion of thyrotropin by the pituitary gland, but has a direct stimulatory effect on thyrocytes. This stimulatory effect is mediated by the serotonin 5-HT2 receptors. In hypothyroidism synthesis and metabolism of serotonin in the brain are slowed down. Depression is accompanied by inhibition of the enzyme activity deiodinase type 2, thereby reducing the concentration of serotonin. Activation of 5-HTI receptor lead to increased levels of intracellular calcium, causing inhibition of the promoter of calcitonin gene-associated peptide.
authors: A E
authors: AE
authors: Lychkova
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D006801:Humans; D012701:Serotonin / Q000378:metabolism; D013961:Thyroid Gland / Q000294:innervation* / Q000502:physiology*
chemical_list: D012701:Serotonin