title: Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance.
abstract: Nesfatin-1 is an anorexigenic peptide that controls feeding behavior and glucose homeostasis. However, there is little data that exists regarding nesfatin-1 secretion in obese children and young adolescents. The aim of this study is to investigate serum nesfatin-1 in childhood and adolescent obesity and to study potential correlations with food intake, anthropometric indices, body composition and insulin resistance. Forty obese children and adolescents and 40 healthy control subjects were studied. Anthropometric measurements were assessed, dietary food intake was evaluated based on 3-days food record and body composition indices were evaluated using bioelectrical impedance analysis. Lipid profile, fasting blood sugar, fasting insulin and HOMA-IR were measured. Fasting serum nesfatin-1 was quantitatively assayed by ELISA. Serum nesfatin-1 was significantly higher in obese group (2.49±1.96 ng/ml) than in control group (0.70±0.81 ng/ml), P=0.001. Positive correlations with serum insulin (P=0.001), HOMA-IR (P=0.000), BMI-SDS (P=0.04), body fat % (P=0.000), fat mass (P=0.000), fat free mass (P=0.03), CHO % (P=0.000), and saturated fat % (P=0.01) were found. While significant negative correlation with protein % (P=0.000) was observed. In conclusion, our results denote that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of insulin resistance in obese children and young adolescents.
authors: Pediatric Department, Cairo University, Egypt.
authors: Ghada M
authors: GM
authors: Anwar
authors: Pediatric Department, National Research Centre, Egypt.
authors: Gamal
authors: G
authors: Yamamah
authors: Pediatric Department, Cairo University, Egypt.
authors: Amani
authors: A
authors: Ibrahim
authors: Clinical and Chemical Pathology Department, National Research Centre, Egypt. Electronic address: d_lebedy@yahoo.co.uk.
authors: Dalia
authors: D
authors: El-Lebedy
authors: Pediatric Department, National Research Centre, Egypt.
authors: Tarek M
authors: TM
authors: Farid
authors: Pediatric Department, National Research Centre, Egypt.
authors: Rasha
authors: R
authors: Mahmoud
mesh_terms: D000293:Adolescent; D001823:Body Composition; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D004268:DNA-Binding Proteins / Q000097:blood*; D004032:Diet; D004435:Eating; D002149:Energy Intake; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D009765:Obesity / Q000097:blood*
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Body composition; Food intake; Insulin resistance; Nesfatin; Obesity