title: Association of C-reactive protein levels with fasting and postload glucose levels according to glucose tolerance status.
abstract: OBJECTIVE
  Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status.
  
  
  METHODS
  A total of 169 healthy males and non-pregnant females aged 18-65 years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n = 82), impaired fasting glucose (IFG) (n = 54), and impaired glucose tolerance (IGT) (n = 33). Elevated CRP was defined by CRP levels >3.0 and <10.0 mg/L, IFG by FPG ≥100 and <126 mg/dL, and IGT by plasma glucose concentration 2 h postload ≥140 and <200 mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2 h postload glucose levels (dependent variables).
  
  
  RESULTS
  Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (β = 0.536; 95% CI 1.03-5.1, p = 0.005) and 2 h postload glucose (β = 0.209; 95% CI 1.31-2.97, p = 0.01) in the IGT group, but not with FPG (β = 0.147; 95% CI 0.55-2.0, p = 0.25) and 2 h postload glucose (β = 0.151; 95% CI 0.83-3.2, p = 0.24) in the IFG group.
  
  
  CONCLUSIONS
  Elevated CRP levels are associated with FPG and 2 h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.
authors: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico.
authors: Fernando
authors: F
authors: Guerrero-Romero
authors: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico. Electronic address: luis_simental81@hotmail.com.
authors: Luis E
authors: LE
authors: Simental-Mendía
authors: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico.
authors: Martha
authors: M
authors: Rodríguez-Morán
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood*; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012306:Risk
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein
keywords: C-reactive protein; Fasting plasma glucose; Glucose tolerance status; Postload glucose