title: The ING tumor suppressor genes: status in human tumors.
abstract: ING genes (ING1-5) were identified has tumor suppressor genes. ING proteins are characterized as Type II TSGs since they are involved in the control of cell proliferation, apoptosis and senescence. They may also function as Type I TSGs since they are also involved in DNA replication and repair. Most studies have reported that they are frequently lost in human tumors and epigenetic mechanisms or misregulation of their transcription may be involved. Recently, studies have described that this loss may be caused by microRNA inhibition. Here, we summarize the current knowledge on ING functions, their involvement in tumor suppression and, in order to give a full assessment of the current knowledge, we review all the studies that have examined ING status in human cancers.
authors: INSERM U917, Microenvironnement et Cancer, Rennes, France; Université de Rennes 1, Rennes, France.
authors: Claire
authors: C
authors: Guérillon
authors: INSERM U917, Microenvironnement et Cancer, Rennes, France; Université de Rennes 1, Rennes, France.
authors: Nicolas
authors: N
authors: Bigot
authors: INSERM U917, Microenvironnement et Cancer, Rennes, France; Université de Rennes 1, Rennes, France; Etablissement Français du Sang, Rennes, France. Electronic address: remy.pedeux@univ-rennes1.fr.
authors: Rémy
authors: R
authors: Pedeux
mesh_terms: D000818:Animals; D016147:Genes, Tumor Suppressor; D006801:Humans; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C501503:ING1 protein, human; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins; D035683:MicroRNAs; D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins
keywords: ING1; ING4; MicroRNA; Tumor suppressor gene; p53