title: Serum IGF-1 levels as a clinical tool for optimizing orthodontic treatment timing.
abstract: BACKGROUND
  The study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages.
  
  
  METHODS
  The study was conducted on 45 male subjects who were at skeletal maturation stage CS-3, CS-4, and CS-5. Subjects were selected using simple random sampling technique. Serum IGF-1 levels were estimated from blood samples using chemiluminescence immunoassay (CLIA) method. CS was evaluated using a six-stage method of evaluating the cervical vertebrae. Mean IGF-1 levels between the stages were compared by analysis of variance (ANOVA) test.
  
  
  RESULTS
  One-way ANOVA showed highly significant differences between all cervical stages with p value<0.01, but post hoc Tukey test showed highly significant differences between CS-4 and CS-5 with p value 0.006. Serum IGF-1 levels showed good association with skeletal age in male subjects; 53.3% of subjects at CS-3, 66.7% subjects at CS-4, and 6.7% subjects at CS-5 showed IGF-1 levels in peak range.
  
  
  CONCLUSIONS
  Serum IGF levels can be used as an additional tool to optimize orthodontic treatment timing.
authors: Department of Orthodontics & Dentofacial Orthopedics, Government College of Dentistry, Opp, Maharaja Yashwantrao Hospital, Indore, India. sapnajainorthogdcindore@gmail.com.
authors: Sapna
authors: S
authors: Jain
authors: Sandhya
authors: S
authors: Jain
authors: Anuradha
authors: A
authors: Deoskar
authors: V S Sai
authors: VS
authors: Prasad
mesh_terms: D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D002508:Cephalometry / Q000379:methods; D002574:Cervical Vertebrae / Q000254:growth & development*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D049449:Luminescence; D008297:Male; D008311:Malocclusion, Angle Class I / Q000097:blood; D008312:Malocclusion, Angle Class II / Q000097:blood; D009971:Orthodontics, Corrective; D013997:Time Factors
chemical_list: D007334:Insulin-Like Growth Factor I