title: Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release.
abstract: The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific modification of various peptides and proteins. Herein, we present the intracellular disintegration of bis-sulfide containing somatostatin bioconjugates under controlled, tumor-relevant glutathione levels. GSH responsive release is demonstrated, which offers high potential for designing tumor responsive therapeutics.
authors: Institute of Organic Chemistry III, University of Ulm, Albert-Einstein-Allee 11, Ulm, Germany. tanja.weil@uni-ulm.de.
authors: Tao
authors: T
authors: Wang
authors: David Y W
authors: DY
authors: Ng
authors: Yuzhou
authors: Y
authors: Wu
authors: Jessica
authors: J
authors: Thomas
authors: Thuy
authors: T
authors: TamTran
authors: Tanja
authors: T
authors: Weil
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry* / Q000378:metabolism*; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D013004:Somatostatin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D004220:Disulfides; D004337:Drug Carriers; D013004:Somatostatin; D004317:Doxorubicin; D005978:Glutathione