title: The expression of matrix metalloproteinases in placental tissue depends on the severity of undifferentiated connective tissue dysplasia.
abstract: Immunohistochemical study of MMP-2 and MMP-9 expression in placental tissue of pregnant patients with undifferentiated connective tissue dysplasia of different severity showed that more severe condition was associated with higher expression of these MMP, this underlying the development of pregnancy and labor complications. The most pronounced elevation of the studied MMP levels was found in the basal plate decidual cells in women with undifferentiated connective tissue dysplasia of more than 18 score.
authors: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. e_dubova@oparina4.ru.
authors: E A
authors: EA
authors: Dubova
authors: I V
authors: IV
authors: Klimantsev
authors: K A
authors: KA
authors: Pavlov
authors: G V
authors: GV
authors: Kulikova
authors: N E
authors: NE
authors: Kan
authors: A I
authors: AI
authors: Shchyogolev
authors: G T
authors: GT
authors: Sukhikh
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009928:Organ Specificity; D010920:Placenta / Q000201:enzymology* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology* / Q000473:pathology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9