title: Next-generation transgenic mice for optogenetic analysis of neural circuits.
abstract: Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
authors: Department of Neurobiology, Duke University Medical Center Durham, NC, USA.
authors: Brent
authors: B
authors: Asrican
authors: George J
authors: GJ
authors: Augustine
authors: Ken
authors: K
authors: Berglund
authors: Susu
authors: S
authors: Chen
authors: Nick
authors: N
authors: Chow
authors: Karl
authors: K
authors: Deisseroth
authors: Guoping
authors: G
authors: Feng
authors: Bernd
authors: B
authors: Gloss
authors: Riichiro
authors: R
authors: Hira
authors: Carolin
authors: C
authors: Hoffmann
authors: Haruo
authors: H
authors: Kasai
authors: Malvika
authors: M
authors: Katarya
authors: Jinsook
authors: J
authors: Kim
authors: John
authors: J
authors: Kudolo
authors: Li Ming
authors: LM
authors: Lee
authors: Shun Qiang
authors: SQ
authors: Lo
authors: James
authors: J
authors: Mancuso
authors: Masanori
authors: M
authors: Matsuzaki
authors: Ryuichi
authors: R
authors: Nakajima
authors: Li
authors: L
authors: Qiu
authors: Gregory
authors: G
authors: Tan
authors: Yanxia
authors: Y
authors: Tang
authors: Jonathan T
authors: JT
authors: Ting
authors: Sachiko
authors: S
authors: Tsuda
authors: Lei
authors: L
authors: Wen
authors: Xuying
authors: X
authors: Zhang
authors: Shengli
authors: S
authors: Zhao
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D051379:Mice; D008822:Mice, Transgenic; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D062308:Optogenetics / Q000379:methods*; D012243:Rhodopsin / Q000235:genetics
chemical_list: D012243:Rhodopsin
keywords: cerebellum; channelrhodopsin; cortex; hippocampus; optogenetics; photoinhibition; photostimulation; pons