title: Bedside to bench: The risk of bleeding with parenteral omega-3 lipid emulsion therapy.
abstract: Our clinical experience led us to reassess the effect of sole omega-3 lipid therapy on hemostasis. We compared thromboelastography platelet mapping in neonatal piglets given sole omega-3 lipid. We identified abnormalities in reaction time (P = .025) and the arachidonic acid pathway (P = .025). The potential for bleeding complications from parenteral omega-3 lipid emulsion therapy in high-risk infants with liver disease has been dismissed but, on the basis of this data, should be reconsidered.
authors: Pediatric General Surgery, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Electronic address: bdicken@ualberta.ca.
authors: Bryan J
authors: BJ
authors: Dicken
authors: Pediatric Hematology and Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: Aisha
authors: A
authors: Bruce
authors: Pediatric Gastroenterology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada.
authors: Tarah M
authors: TM
authors: Samuel
authors: Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Pediatric General Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
authors: Paul W
authors: PW
authors: Wales
authors: Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
authors: Susan
authors: S
authors: Nahirniak
authors: Pediatric Gastroenterology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Agriculture, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada.
authors: Justine M
authors: JM
authors: Turner
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D002405:Catheterization, Central Venous / Q000009:adverse effects; D004195:Disease Models, Animal; D004655:Emulsions / Q000008:administration & dosage; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005395:Fish Oils / Q000008:administration & dosage / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000150:complications / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology; D008297:Male; D010288:Parenteral Nutrition; D010743:Phospholipids / Q000008:administration & dosage; D010979:Platelet Function Tests; D013024:Soybean Oil / Q000008:administration & dosage; D013552:Swine; D013916:Thrombelastography; D014280:Triglycerides
chemical_list: D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D010743:Phospholipids; D014280:Triglycerides; C568345:fish oil triglycerides; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil