title: Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder characterized by the progressive and selective loss of both upper and lower motoneurons. The neurodegenerative process is accompanied by a sustained inflammation in the brain and spinal cord. The neuron-immune interaction, implicating resident microglia of the central nervous system and blood-derived immune cells, is highly dynamic over the course of the disease. Here, we discuss the timely controlled neuroprotective and neurotoxic cues that are provided by the immune environment of motoneurons and their potential therapeutic applications for ALS.
authors: The Neuroscience Institute of Montpellier, INM, INSERM UMR1051, Saint Eloi Hospital Montpellier, France.
authors: Melissa
authors: M
authors: Bowerman
authors: Thierry
authors: T
authors: Vincent
authors: Frédérique
authors: F
authors: Scamps
authors: Florence E
authors: FE
authors: Perrin
authors: William
authors: W
authors: Camu
authors: Cédric
authors: C
authors: Raoul
keywords: astrocytes; cytokine; hyperexcitability; inflammation; lymphocytes; microglia; therapy