title: Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality.
abstract: Gold nanoparticles (AuNPs) coated with ester-headed or ether-headed PEG ligands were synthesized. Ester-headed AuNPs, but not ether-headed, were transferred from the organic phase (CH2Cl2) to the alkali aqueous phase, indicating that the hydrolysis of the ester moiety triggered the phase transfer of the AuNPs. We found that AuNPs with ester-headed ligands (ester-AuNPs) were internalized into HeLa cells at a greater level than were ether-headed AuNPs.
authors: Nano Medical Engineering Laboratory, RIKEN, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
authors: Kenya
authors: K
authors: Kobayashi
authors: Kenichi
authors: K
authors: Niikura
authors: Chie
authors: C
authors: Takeuchi
authors: Shota
authors: S
authors: Sekiguchi
authors: Takafumi
authors: T
authors: Ninomiya
authors: Kyoji
authors: K
authors: Hagiwara
authors: Hideyuki
authors: H
authors: Mitomo
authors: Yoshihiro
authors: Y
authors: Ito
authors: Yoshihito
authors: Y
authors: Osada
authors: Kuniharu
authors: K
authors: Ijiro
mesh_terms: D004952:Esters / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D013054:Spectrophotometry, Atomic
chemical_list: D004952:Esters; D006046:Gold