title: Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: emerging role of supracricoid partial laryngectomy.
abstract: BACKGROUND
  Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences of laryngeal squamous cell carcinoma (SCC) after a first attempt of organ preservation.
  
  
  METHODS
  The clinical records of 68 consecutive patients primarily treated by irradiation or endoscopic surgery and surgically salvaged by total laryngectomy or supracricoid partial laryngectomy in 2 large university hospitals in Italy from 2004 to 2010 were reviewed.
  
  
  RESULTS
  The survival was not affected by the primary treatment or by salvage modality. The only parameter always keeping a prognostic value is the involvement of resection margins of salvage surgery. Patients with early relapse seem to have a worse prognosis than patients with a delayed relapse (p = .05 at Cox multivariate analysis and p = .048 at Wilcoxon test for overall survival [OS] from the primary treatment).
  
  
  CONCLUSIONS
  Supracricoid operations, if the indications are careful, can prove reliable salvage procedures.
authors: Department of Sensorial Organs, Ear, Nose, and Throat Section, "Sapienza" University of Rome, Italy.
authors: Marco
authors: M
authors: de Vincentiis
authors: Armando
authors: A
authors: De Virgilio
authors: Francesco
authors: F
authors: Bussu
authors: Roberto
authors: R
authors: Gallus
authors: Andrea
authors: A
authors: Gallo
authors: Giovanni
authors: G
authors: Bastanza
authors: Claudio
authors: C
authors: Parrilla
authors: Antonio
authors: A
authors: Greco
authors: Jacopo
authors: J
authors: Galli
authors: Rosaria
authors: R
authors: Turchetta
authors: Giovanni
authors: G
authors: Almadori
authors: Giulio
authors: G
authors: Pagliuca
authors: Vincenzo
authors: V
authors: Valentini
authors: Gaetano
authors: G
authors: Paludetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003413:Cricoid Cartilage; D005260:Female; D006801:Humans; D007558:Italy; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D016896:Treatment Outcome
keywords: laryngeal squamous cell carcinoma (SCC); organ preservation; prognostic factors; salvage surgery; supracricoid surgery