title: [Level of sIgA, IgG, IgA in vaginal secretion in women with chronic inflammatory disease of small pelvis organs].
abstract: OBJECTIVE
  Determine levels of sIgA, IgG, IgA in vaginal secretion and saliva of women of reproductive age with chronic inflammatory diseases of small pelvis organs (IDSPO) at exacerbation stage and remission period.
  
  
  METHODS
  Clinical-laboratory and gynecological examination of 105 women was carried out. Based on the results obtained 3 groups were formed: patients with IDSPO at exacerbation stage; patients at remission stage; clinically healthy women. sIgA, IgG, IgA parameters were studied in vaginal secretion and saliva in women with IDSPO at exacerbation stage and remission period by radial immune diffusion in gel by Manchini method.
  
  
  RESULTS
  An increase of immunoglobulin level in vaginal secretion of women with IDSPO at remission period and a sharper increase of these parameters during exacerbation of the disease compared with women of the control group were detected. During analysis of sIgA, IgG, IgA levels in saliva in the same groups of women the results were obtained that give evidence that the presence of IDSPO and local immune reaction do not lead to the changes of these parameters.
  
  
  CONCLUSIONS
  The obtained parameters on the dependence of an increase of immunoglobulin levels in vaginal secretions and the degree of intensity of the inflammatory process give basis to use them with the aim of additional diagnostics.
authors: L V
authors: LV
authors: Shibina
authors: L I
authors: LI
authors: Krasnoproshina
authors: I M
authors: IM
authors: Ordiiants
authors: O V
authors: OV
authors: Slatinova
authors: S A
authors: SA
authors: Skhodova
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology / Q000302:isolation & purification; D007071:Immunoglobulin A, Secretory / Q000276:immunology / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000276:immunology / Q000302:isolation & purification; D007239:Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D057892:Lesser Pelvis / Q000473:pathology; D008875:Middle Aged; D012463:Saliva / Q000276:immunology; D014621:Vagina / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014626:Vaginal Smears
chemical_list: D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G