title: Association between exposure to environmental tobacco smoke and biomarkers of oxidative stress among patients hospitalised with acute myocardial infarction.
abstract: OBJECTIVE
  To determine whether exposure to environmental tobacco smoke was associated with oxidative stress among patients hospitalised for acute myocardial infarction.
  
  
  METHODS
  An existing cohort study of 1,261 patients hospitalised for acute myocardial infarction.
  
  
  METHODS
  Nine acute hospitals in Scotland.
  
  
  METHODS
  Sixty never smokers who had been exposed to environmental tobacco smoke (admission serum cotinine ≥3.0 ng/mL) were compared with 60 never smokers who had not (admission serum cotinine ≤0.1 ng/mL).
  
  
  METHODS
  None.
  
  
  METHODS
  Three biomarkers of oxidative stress (protein carbonyl, malondialdehyde (MDA) and oxidised low-density lipoprotein (ox-LDL)) were measured on admission blood samples and adjusted for potential confounders.
  
  
  RESULTS
  After adjusting for baseline differences in age, sex and socioeconomic status, exposure to environmental tobacco smoke was associated with serum concentrations of both protein carbonyl (beta coefficient 7.96, 95% CI 0.76, 15.17, p = 0.031) and MDA (beta coefficient 10.57, 95% CI 4.32, 16.81, p = 0.001) but not ox-LDL (beta coefficient 2.14, 95% CI -8.94, 13.21, p = 0.703).
  
  
  CONCLUSIONS
  Exposure to environmental tobacco smoke was associated with increased oxidative stress. Further studies are requires to explore the role of oxidative stress in the association between environmental tobacco smoke and myocardial infarction.
authors: Free Radical Research Facility, Department of Diabetes and Cardiovascular Science, University of Highlands and Islands, Inverness, United Kingdom.
authors: Ian L
authors: IL
authors: Megson
authors: Sally J
authors: SJ
authors: Haw
authors: David E
authors: DE
authors: Newby
authors: Jill P
authors: JP
authors: Pell
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D012906:Smoke / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D012906:Smoke; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde