title: Clinical features in association with neurodegenerative diseases and malignancies.
abstract: OBJECTIVE
  To examine whether there are clinical features in Japanese patients with both neurodegenerative diseases and cancers.
  
  
  METHODS
  We analyzed the clinical characteristics of consecutive Japanese patients with neurodegenerative diseases during the past 5 years, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), dementia with Lewy bodies, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA).
  
  
  RESULTS
  Out of 292 patients, 39 patients had cancers, including a past history, as follows: ALS, n = 16; PD, n = 8; PSP, n = 7; CBD, n = 1, and MSA, n = 7. About 10% of patients with neurodegenerative diseases developed cancer after onset of the disease; about 30% of patients with ALS, PD, or PSP occurring with cancers died of cancer. Gastric cancer was most common before the onset of ALS (62.5%) but did not develop after the onset of ALS. Conversely, PD patients frequently developed gastric cancers after the onset of neurological signs (60.0%) in spite of no cancer before the onset of PD. The proportion of breast cancer in MSA (45.5%) was significantly higher than in other neurodegenerative diseases.
  
  
  CONCLUSIONS
  ALS, PD, or MSA patients with cancer showed clinical characteristics unique to each neurodegenerative disease in Japan compared to other countries.
authors: Department of Neurology, National Hospital Organization Iou National Hospital, Kanazawa, Japan.
authors: Ichiro
authors: I
authors: Nozaki
authors: Yuko
authors: Y
authors: Kato-Motozaki
authors: Tokuhei
authors: T
authors: Ikeda
authors: Atsuro
authors: A
authors: Tagami
authors: Kazuya
authors: K
authors: Takahashi
authors: Chiho
authors: C
authors: Ishida
authors: Kiyonobu
authors: K
authors: Komai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000453:epidemiology*; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies