title: Dynamics of fertility in patients on waiting list for kidney transplantation.
abstract: OBJECTIVE
  To evaluate the presence of hormonal abnormalities and fertility disorders in patients with chronic kidney disease (CKD) awaiting renal transplantation.
  
  
  METHODS
  From September 2009 to April 2011 all male patients with CKD awaiting kidney transplantation were investigated. The following tests were performed: semen analysis, serum concentration of testosterone, SHBG, LH, FSH and prolactin. Differences in hormone levels and sperm count parameters were statistically evaluated between the control group and the patient group.
  
  
  RESULTS
  The group of patients consisted of 74 and the control group of 41 men. Average testosterone levels were lower in patients compared to control group. In patients significantly higher levels of SHBG, LH, FSH and PRL were found, and statistically significantly lower ejaculate volume, total sperm count, sperm concentration, total and progressive sperm motility and sperm morphology than in the control group. Within the group of patients a negative correlation between testosterone and PRL was found and a positive correlation between testosterone and total sperm motility and morphology. A negative correlation was detected between the duration of haemodialysis and testosterone, sperm concentration, total and progressive motility and sperm morphology.
  
  
  CONCLUSIONS
  Significant changes in hormone levels and impaired fertility are found in haemodialyzed patients on a waiting list for kidney transplantation. The dynamics of these changes are dependent on the duration of haemodialysis (Tab. 4, Fig. 2, Ref. 15). Text in PDF www.elis.sk.
authors: R
authors: R
authors: Zachoval
authors: J
authors: J
authors: Jarabak
authors: J
authors: J
authors: Slatinska
authors: M
authors: M
authors: Burgelova
authors: V
authors: V
authors: Sobotka
authors: J
authors: J
authors: Vranova
authors: J
authors: J
authors: Krhut
mesh_terms: D000293:Adolescent; D000328:Adult; D005298:Fertility / Q000502:physiology*; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055101:Semen Analysis; D014850:Waiting Lists; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones
keywords: chronic kidney disease, fertility, haemodialysis, kidney transplantation, spermiogram.