title: [Effect of pamidronate and ibandronate on orthodontic root resorption in rats].
abstract: OBJECTIVE
  To compare the effects of pamidronate and ibandronate on orthodontic root resorption.
  
  
  METHODS
  Seventy-two 6-week-old female specific pathogen free (SPF) Wistar rats were selected to establish models for orthodontic tooth movement. The rats were randomly divided into three groups: the control group (C group), pamidronate group (Pm group) and ibandronate group (Ib group). 0.9% normal saline,0.5 mmol/L pamidronate and 0.5 mmol/L ibandronate were injected every 3 days. The rats were executed in batch on the 3rd, 7th and 14th day to make tissue sections. All statistical analysis was performed using the PASW Statistics 18 software package.
  
  
  RESULTS
  On the 7th and 14th day, the amount of cementoclast, the expression of osteoclast differentiation factor (ODF) and root resorption index were significantly lower in Pm group [the 7th day: (2.675 ± 0.002), (0.1683 ± 0.0007), (0.103 ± 0.003); the 14th day: (3.886 ± 0.048), (0.1873 ± 0.0014), (0.283 ± 0.001)] and Ib groups[the 7th day: (2.601 ± 0.001), (0.1634 ± 0.0010), (0.099 ± 0.002); the 14th day: (3.754 ± 0.019), (0.1818 ± 0.0016), (0.281 ± 0.001)] than in C group[the 7th day: (2.810 ± 0.001), (0.1792 ± 0.0008), (0.120 ± 0.001); the 14th day: (4.800 ± 0.001), (0.2060 ± 0.0007), (0.401 ± 0.001)] (P < 0.05). However, no significant difference was found between Pm and Ib groups on the 3rd, 7th and 14th day (P > 0.05).
  
  
  CONCLUSIONS
  Both pamidronate and ibandronate could inhibit orthodontic root resorption.
authors: Department of Orthodontics, School of Stomatology, Shandong University; Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China.
authors: Shu-ya
authors: SY
authors: Zhao
authors: Xu-xia
authors: XX
authors: Wang
authors: Wan-xin
authors: WX
authors: Liu
authors: Rui
authors: R
authors: Dong
authors: Jing
authors: J
authors: Li
authors: Jun
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002452:Cell Count; D004164:Diphosphonates / Q000494:pharmacology*; D005260:Female; D000077557:Ibandronic Acid; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000077268:Pamidronate; D053245:RANK Ligand / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000473:pathology / Q000517:prevention & control*; D014087:Tooth Movement Techniques
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D053245:RANK Ligand; D000077268:Pamidronate; D000077557:Ibandronic Acid