title: [Differences in pathological features of histological inflammation between benign prostatic hyperplasia and prostate cancer].
abstract: OBJECTIVE
  To study the pathologic features and differences of tissue inflammation in benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
  
  
  METHODS
  The HE stained slice obtained by prostate biopsy from 143 BPH and 106 PCa were reviewed to determine whether the tissue inflammation existed. According to the histological classification of prostatic tissue inflammation, the features of tissue inflammation and the differences of these features between the two groups were studied in detail.
  
  
  RESULTS
  There were 142 cases found tissue inflammation in 143 BPH patients and 104 cases in 106 PCa patients, so the incidences of tissue inflammation in BPH and PCa were 99. 3% and 98. 1% respectively. The anatomical location of inflammation was significant difference between BPH and PCa group (P<0. 05). The peri-glandular inflammation (56. 3%) was primary in BPH, and interstitial inflammation (56.7%) was the main pattern in PCa. The inflammation range was also significant difference between the two groups (P<0. 05). The inflammation was presented multifocally (60. 6%) in BPH, and focal lesions (51. 0%) was commonly found in PCa. Mild inflammation was most frequently observed in both groups (P>0. 05). However, there were statistically significant differences between the two groups in the degree of moderate and severe inflammation (P<0. 05).
  
  
  CONCLUSIONS
  The incidences of tissue inflammation were high in both BPH and PCa, but the pathological features of tissue inflammation were different between BPH and PCa.
authors: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Lu
authors: L
authors: Yang
authors: Kai
authors: K
authors: Zhao
authors: Ao
authors: A
authors: Zhang
authors: Liang-Ren
authors: LR
authors: Liu
authors: Zhen-Hua
authors: ZH
authors: Liu
authors: Ping
authors: P
authors: Han
authors: Qiang
authors: Q
authors: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002681:China; D003176:Complement C3 / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology*
chemical_list: D003176:Complement C3; D016209:Interleukin-8