title: Interferons beta have vasoconstrictive and procoagulant effects: a woman who developed livedo reticularis and Raynaud phenomenon in association with interferon beta treatment for multiple sclerosis.
abstract: A 31-year-old woman with MS developed livedo reticularis and secondary Raynaud phenomenon 2.5 years after introduction of interferon beta-1b. The symptoms disappeared after withdrawal of the drug. Livedo reticularis and Raynaud phenomenon as well as pulmonary arterial hypertension, venous sinus thrombosis, pulmonary embolism and renal thrombotic microangiopathy have all been described in association with interferon beta therapy. These complications strongly suggest that type I interferons have vasoconstrictive and procoagulant effects with potentially serious systemic complications.
authors: Department of Neurology, University Medical Centre, Zaloška cesta 2, 1525 Ljubljana, Slovenia. Electronic address: uros.rot@guest.arnes.si.
authors: Uroš
authors: U
authors: Rot
authors: Alenka Horvat
authors: AH
authors: Ledinek
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects*; D054068:Livedo Reticularis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011928:Raynaud Disease / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D000068576:Interferon beta-1b; D016899:Interferon-beta
keywords: Interferon beta; Livedo reticularis; Multiple sclerosis; Raynaud phenomenon; Side effects