title: Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population.
abstract: Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension in a Chinese Han population. A hospital-based case-control study in a Chinese Han population was carried out, including 500 hypertension patients and 506 healthy controls. The five SNP markers were detected using the Sequenom MassArray(®) iPLEX System. The association of genotypes with susceptibility to hypertension was analyzed using odds ratio, with 95% confidence interval and logistic regression. All five variants conformed to Hardy-Weinberg proportions in the controls. No significant differences were noted in the genotype distributions for AGTR1, PRRC2A, and CALCA polymorphisms in patients with hypertension (N = 500) and healthy controls (N = 506). SNP rs2932538, a variant in MOV10, was found to be significantly associated with an increased risk of hypertension. However, SNP rs4373814, a variant in CACNB2, showed a relevant association with a decreased risk of hypertension. In conclusion, the results of our case-control study confirmed the significant association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population, suggesting that the SNP rs2932538 may be a poor prognostic indicator for hypertension, while SNP rs4373814 may be a good prognostic indicator for hypertension in the same region. However, our findings need to be replicated in larger epidemiological and functional studies.
authors: Department of Laboratory Medicine, The Fuzhou Second Affiliated Hospital of Xiamen University, Fujian, China.
authors: G L
authors: GL
authors: Hong
authors: X Z
authors: XZ
authors: Chen
authors: Y
authors: Y
authors: Liu
authors: Y H
authors: YH
authors: Liu
authors: X
authors: X
authors: Fu
authors: S B
authors: SB
authors: Lin
authors: Q
authors: Q
authors: Zhu
mesh_terms: D000328:Adult; D044466:Asian People; D020746:Calcium Channels, L-Type / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020365:RNA Helicases / Q000235:genetics*; D012307:Risk Factors
chemical_list: C107597:CACNB2 protein, human; D020746:Calcium Channels, L-Type; C530476:Mov10 protein, human; D020365:RNA Helicases