title: [Regulation of the self-renewal and differentiation of spermatogonial stem cells].
abstract: Spermatogonial stem cells (SSCs) play an important role in spermatogenesis and have a unique mode of replication. A single SSC can produce two differentiating cells, or one stem cell and one differentiating cell. The self-renewal and differentiation of SSCs are precisely regulated as relating the niche of SSCs, glial cell line-derived neurotrophic factor, and several signaling pathways. This article reviews the self-renewal and differentiation of SSCs and their regulation mechanisms, which may offer a deeper insight into spermatogenesis and male infertility and pave a theoretical ground for studying testicular tumorigenesis and searching for new potential approaches to the treatment of testicular cancer and other related diseases.
authors: Laboratory of Immunology and Reproductive Biology, Nanjing University School of Medicine, Nanjing, Jiangsu 210093, China. lidm@nju.edu.cn
authors: Dong-Mei
authors: DM
authors: Li
authors: Laboratory of Immunology and Reproductive Biology, Nanjing University School of Medicine, Nanjing, Jiangsu 210093, China.
authors: Xiao-Dong
authors: XD
authors: Qin
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D013091:Spermatogenesis; D013093:Spermatogonia / Q000166:cytology*; D033581:Stem Cell Transplantation