title: HIF and pulmonary vascular responses to hypoxia.
abstract: In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension. Data from both human subjects and animal models implicate a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary vascular responses to both acute and chronic hypoxia. In this review, we discuss work from our laboratory and others supporting a role for HIF in modulating hypoxic pulmonary vasoconstriction and mediating hypoxia-induced pulmonary hypertension, identify some of the downstream targets of HIF, and assess the potential to pharmacologically target the HIF system.
authors: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Larissa A
authors: LA
authors: Shimoda
authors: Steven S
authors: SS
authors: Laurie
mesh_terms: D000208:Acute Disease; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D051793:Hypoxia-Inducible Factor 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D051793:Hypoxia-Inducible Factor 1; D014665:Vasodilator Agents
keywords: digoxin; hypoxia inducible factor; hypoxic pulmonary vasoconstriction; pulmonary hypertension