title: [Pre-conception factors for intrauterine growth retardation].
abstract: OBJECTIVE
  To analyze the pre-conception factors for intrauterine growth retardation.
  
  
  METHODS
  A nested case-control study was conducted in a cohort of 1368 women from 14 Child and Maternity Health Care Departments by cluster sampling method in Liuyang City, Hunan Province. Following-up until delivery, we collected their medical records and maternal health care manual materials. All neonates with intrauterine growth retardation were detected in the follow-up (the case group) and another 186 neonates without intrauterine growth retardation, matched with gender and mother's age, were randomly selected from the cohort as controls. χ2 test and multiple conditional logistic regression were used to investigate the determinants of intrauterine growth retardation.
  
  
  RESULTS
  Intrauterine growth retardation was associated with BMI (OR=64.775), waist circumference (OR=0.166), abortion (OR=6.997), level of total cholesterol (OR=0.045), folic acid (OR=0.077), and cortisol (OR=9.164).
  
  
  CONCLUSIONS
  Intrauterine growth retardation is associated with BMI, waist circumference, abortion,level of total cholesterol, folic acid, and cortisol. Effective measures to reduce intrauterine growth retardation in children include strengthening the detection of pre-pregnancy blood biochemical indicators to guide health care during pregnancy, and increasing nutrition during pregnancy according to pre-pregnancy BMI and waist circumference.
authors: Department of Epidemiology and Health Statistics, Central South University, Changsha 410078,China.
authors: Li
authors: L
authors: Hu
authors: Hongzhuan
authors: H
authors: Tan
authors: Shujin
authors: S
authors: Zhou
authors: Yue
authors: Y
authors: He
authors: Lin
authors: L
authors: Shen
authors: Yi
authors: Y
authors: Liu
authors: Shiwu
authors: S
authors: Wen
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D012307:Risk Factors