title: Innovative therapies in Ewing Sarcoma.
abstract: Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of new therapeutic targets, many questions still remain open. In this review we focus on the research on targeted therapies in this malignancy, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research.
authors: *Molecular Pathology Program, Institute of Biomedical Research of Salamanca-Centro de Investigación del Cáncer, Centro de Investigación del Cancér (IBSAL-CIC), Campus Miguel de Unamuno S/N, Salamanca †Pathology Department, Hospital Universitario Virgen del Rocio-IBiS, Sevilla, Spain.
authors: Ana Teresa
authors: AT
authors: Amaral
authors: José Luis
authors: JL
authors: Ordóñez
authors: Ana Pastora
authors: AP
authors: Otero-Motta
authors: Daniel J
authors: DJ
authors: García-Domínguez
authors: María Victoria
authors: MV
authors: Sevillano
authors: Enrique
authors: E
authors: de Álava
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D012512:Sarcoma, Ewing / Q000235:genetics / Q000628:therapy*; D035703:Therapies, Investigational