title: γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
abstract: We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that γ-mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.
authors: Department of Life Science, Faculty of Science, Okayama University of Science.
authors: Nobuyasu
authors: N
authors: Matsuura
authors: Kanae
authors: K
authors: Gamo
authors: Hiroyuki
authors: H
authors: Miyachi
authors: Munekazu
authors: M
authors: Iinuma
authors: Teruo
authors: T
authors: Kawada
authors: Nobuyuki
authors: N
authors: Takahashi
authors: Yukihiro
authors: Y
authors: Akao
authors: Hideki
authors: H
authors: Tosa
mesh_terms: D000818:Animals; D002460:Cell Line; D005638:Fruit / Q000737:chemistry*; D029762:Garcinia mangostana / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D024101:Mitochondrial Proteins / Q000235:genetics; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism*; D047494:PPAR delta / Q000819:agonists* / Q000378:metabolism*; D051381:Rats; D000071247:Uncoupling Protein 3; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D047494:PPAR delta; C000604392:UCP3 protein, human; C000604394:Ucp3 protein, rat; D000071247:Uncoupling Protein 3; D044004:Xanthones; C021053:mangostin