title: Withanolides from Jaborosa caulescens var. bipinnatifida.
abstract: Withanolides 2,3-dihydrotrechonolide A (1) and 2,3-dihydro-21-hydroxytrechonolide A (2) were isolated along with two known withanolides trechonolide A (3) and jaborosalactone 39 (4) from Jaborosa caulescens var. bipinnatifida (Solanaceae). The structures of 1-2 were elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withanolide 1 was confirmed by X-ray crystallographic analysis.
authors: Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA.
authors: Huaping
authors: H
authors: Zhang
authors: Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA.
authors: Cong-Mei
authors: CM
authors: Cao
authors: Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA.
authors: Robert J
authors: RJ
authors: Gallagher
authors: The Small-Molecule X-ray Crystallography Laboratory, University of Kansas, Lawrence, KS 66047, USA.
authors: Victor W
authors: VW
authors: Day
authors: Facultad de Agronomia e Ingenieria Forestal, Universidad Católica de Chile, Vicuna Mackenna 4860 Santiago, Chile.
authors: Gloria
authors: G
authors: Montenegro
authors: Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA. Electronic address: btimmer@ku.edu.
authors: Barbara N
authors: BN
authors: Timmermann
mesh_terms: D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D019657:Solanaceae / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D054358:Withanolides
keywords: 2,3-Dihydro-21-hydroxytrechonolide A; 2,3-Dihydrotrechonolide A; Jaborosa caulescens var. bipinnatifida; Solanaceae; Withanolide