title: Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
abstract: Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
authors: Shuzhao
authors: S
authors: Li
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3].
authors: Nadine
authors: N
authors: Rouphael
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
authors: Sai
authors: S
authors: Duraisingham
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Sandra
authors: S
authors: Romero-Steiner
authors: 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
authors: Scott
authors: 0000000192036403
authors: S
authors: Presnell
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
authors: Carl
authors: C
authors: Davis
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Daniel S
authors: DS
authors: Schmidt
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Scott E
authors: SE
authors: Johnson
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Andrea
authors: A
authors: Milton
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Gowrisankar
authors: G
authors: Rajam
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Sudhir
authors: S
authors: Kasturi
authors: Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: George M
authors: GM
authors: Carlone
authors: 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
authors: Charlie
authors: C
authors: Quinn
authors: 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
authors: Damien
authors: D
authors: Chaussabel
authors: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
authors: A Karolina
authors: AK
authors: Palucka
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
authors: Mark J
authors: MJ
authors: Mulligan
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
authors: Rafi
authors: R
authors: Ahmed
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
authors: David S
authors: DS
authors: Stephens
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors: Helder I
authors: HI
authors: Nakaya
authors: 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors: Bali
authors: B
authors: Pulendran
mesh_terms: D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000235:genetics; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007110:Immunity, Active; D007136:Immunoglobulins / Q000097:blood; D007252:Influenza Vaccines / Q000276:immunology; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology*; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000276:immunology*; D049490:Systems Biology / Q000379:methods*; D059467:Transcriptome; D018074:Vaccines, Conjugate / Q000276:immunology; D022341:Yellow Fever Vaccine / Q000276:immunology; D055815:Young Adult
chemical_list: D007136:Immunoglobulins; D007252:Influenza Vaccines; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate; D022341:Yellow Fever Vaccine