title: Antioxidant, antityrosinase, anticholinesterase, and nitric oxide inhibition activities of three malaysian macaranga species.
abstract: The methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and free radical scavenging activity (IC50 = 0.063 mg/mL). All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M. gigantea exhibiting the highest inhibition of 92.21%. Most of the samples exhibited significant antioxidant potential. The bark of M. denticulata and the leaves of both M. pruinosa and M. gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M. denticulata having the highest percentage of inhibition (68.7%). The bark and leaves of M. denticulata exhibited greater than 50% inhibition (73.82% and 54.50%, resp.) of the acetylcholinesterase enzyme (AChE), while none of the samples showed any significant inhibition of butyrylcholinesterase (BChE). Only the bark of M. denticulata and M. gigantea displayed greater than 50% inhibition of nitric oxide production in cells (81.79% and 56.51%, resp.). These bioactivities indicate that some Macaranga spp. have therapeutic potential in medicinal research.
authors: Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Nor Aishah
authors: NA
authors: Mazlan
authors: Ahmed
authors: A
authors: Mediani
authors: Faridah
authors: F
authors: Abas
authors: Syahida
authors: S
authors: Ahmad
authors: Khozirah
authors: K
authors: Shaari
authors: Shamsul
authors: S
authors: Khamis
authors: N H
authors: NH
authors: Lajis
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004789:Enzyme Activation; D019665:Euphorbiaceae / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013045:Species Specificity
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide; D014442:Monophenol Monooxygenase