title: Relationships between values of antibodies to several connective tissue disease autoantigens and pulmonary function in a Japanese general population: the Takahata study.
abstract: BACKGROUND
  Accumulating evidence suggests the involvement of an autoimmune mechanism in the pathogenesis of respiratory dysfunction. The aim of this study was to investigate the relationship between pulmonary function and serum antibodies to several connective tissue disease autoantigens (ACTDA) levels, which has not been investigated in a general population.
  
  
  METHODS
  Blood sampling and spirometry were performed for subjects (n = 3,257) aged ≥40 years who participated in a community-based annual health check in Takahata, Japan, from 2004 to 2006. ACTDA was measured by enzyme immunoassay, and subjects with ACTDA values ≥20 were defined as positive.
  
  
  RESULTS
  In males, there were significant inverse relationships between logarithmically transformed ACTDA values and spirometric parameters, including % predicted values for forced expiratory volume in 1 s (FEV1) and maximal midexpiratory flow (MMF) as well as FEV1/forced vital capacity (FVC). Multiple linear regression analysis revealed that except for the relationship between ACTDA and FEV1/FVC, these relationships were still significant after adjustment for Brinkman index (a measure of inhaled cigarette consumption). The prevalence of positive ACTDA was greater in male never-smokers with mixed ventilation disorders and relatively severe airflow obstruction (% predicted FEV1 below the median value).
  
  
  CONCLUSIONS
  Autoimmunity may be involved in the mechanism of impaired pulmonary function in the general population.
authors: Department of Cardiology, Pulmonology and Nephrology, School of Medicine, Yamagata University, Yamagata City, Yamagata, Japan.
authors: Hiroshi
authors: H
authors: Nakano
authors: Yoko
authors: Y
authors: Shibata
authors: Sumito
authors: S
authors: Inoue
authors: Akira
authors: A
authors: Igarashi
authors: Keiko
authors: K
authors: Yamauchi
authors: Shuichi
authors: S
authors: Abe
authors: Masamichi
authors: M
authors: Sato
authors: Yasuko
authors: Y
authors: Aida
authors: Keiko
authors: K
authors: Nunomiya
authors: Tomomi
authors: T
authors: Kimura
authors: Takako
authors: T
authors: Nemoto
authors: Tetsu
authors: T
authors: Watanabe
authors: Tsuneo
authors: T
authors: Konta
authors: Yoshiyuki
authors: Y
authors: Ueno
authors: Takeo
authors: T
authors: Kato
authors: Takamasa
authors: T
authors: Kayama
authors: Isao
authors: I
authors: Kubota
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013147:Spirometry
chemical_list: D001323:Autoantibodies; D001324:Autoantigens