title: Ribosome-targeting antibiotics and mechanisms of bacterial resistance.
abstract: The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.
authors: Gene Center and Department for Biochemistry, Feodor-Lynenstr. 25, University of Munich, 81377 Munich, Germany.
authors: Daniel N
authors: DN
authors: Wilson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics; D001426:Bacterial Proteins / Q000096:biosynthesis; D024881:Drug Resistance, Bacterial; D014176:Protein Biosynthesis / Q000187:drug effects; D011487:Protein Conformation; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins