title: Chronic periodontitis and its possible association with oral squamous cell carcinoma - a retrospective case control study.
abstract: BACKGROUND
  Different inflammatory processes may trigger the development of malignancies. Therefore, the aim of the present study was to evaluate a potential association between radiological determined chronic periodontitis (CPA) and oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  In a retrospective study, OSCC-patients and a control group without malignant tumors were radiographically examined for bone loss. Via telephone survey and questionnaire, general clinical data on the individual oral hygiene and concomitant diseases together with tobacco and alcohol use were assessed and data were compared between the groups.
  
  
  RESULTS
  178 OSCC-patients and 123 controls were included. In univariate analysis, a statistically relevant higher mean bone loss was seen in the OSCC group (4.3 mm (SD: 1.8; 95% confidence interval (CI): 4-4.6) vs. 2.9 mm (SD: 0.7; 95% CI: 2.8-3); p < 0.001)). This was confirmed in a multivariate regression model (OR: 2.4, 95% CI: 1.5-3.8; p < 0.001). A history of periodontal treatment was associated with significantly reduced OSCC risk (p < 0.001; OR: 0.2, CI: 0.1-0.5).
  
  
  CONCLUSIONS
  CPA is a common disease and the monitoring as well as the treatment of such a chronic oral inflammation may be beneficial in reducing one potential cause of OSCC. Therefore, further clinical studies on oral neoplasms should consider clinical periodontal parameters as well.
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Mainz, Augustusplatz 2, Mainz 55131, Germany. maximilian.moergel@unimedizin-mainz.de.
authors: Maximilian
authors: M
authors: Moergel
authors: Peer
authors: P
authors: Kämmerer
authors: Adrian
authors: A
authors: Kasaj
authors: Evangelia
authors: E
authors: Armouti
authors: Abdulmonem
authors: A
authors: Alshihri
authors: Veronika
authors: V
authors: Weyer
authors: Bilal
authors: B
authors: Al-Nawas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000503:physiopathology; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D015999:Multivariate Analysis; D010518:Periodontitis / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D011322:Primary Prevention; D012189:Retrospective Studies; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck