title: [Study on patients with Creutzfeldt-Jakob disease in Shanghai, 2006-2012].
abstract: OBJECTIVE
  To describe the epidemiological characteristics of patients with Creutzfeldt-Jakob disease (CJD) in Shanghai from 2006 to 2012.
  
  
  METHODS
  Clinical and epidemiological information on CJD patients from Shanghai CJD Surveillance Network was analyzed. Cerebral spinal fluid (CSF)and blood specimens from patients were collected and used for detecting the 14-3-3 protein, and polymorphism of 129 amino acid and mutation of PRNP genes. Data was processed by EpiData(V3.0)and analyzed by SPSS(V17.0).
  
  
  RESULTS
  In totally, one definite CJD patient together with 56 probable and 17 possible sporadic CJD patients were identified. One E200K genetic CJD case was diagnosed and another one was clinically diagnosed. No period- or geographic-related events were observed for these cases, but the houses of the two genetic CJD cases were close to each other. The mean age of onset of the probable CJD patients was 62 years old which was significantly older than that of those possible CJD patients.
  
  
  CONCLUSIONS
  Most of the CJD patients identified in Shanghai were sporadic and the number was stable from 2006 to 2012. The mean age of onset of those probable CJD patients was older than that of the possible CJD patients.
authors: Department of Acute Communicable Disease Control.
authors: Pu
authors: P
authors: Huang
authors: Department of Acute Communicable Disease Control.
authors: Yi-yi
authors: YY
authors: Zhu
authors: Department of Acute Communicable Disease Control.
authors: Jia-yu
authors: JY
authors: Hu
authors: Department of Acute Communicable Disease Control.
authors: Chen-yan
authors: CY
authors: Jiang
authors: School of Public Health, Fudan University.
authors: Bo
authors: B
authors: Chen
authors: Department of Science and Education, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
authors: Hong
authors: H
authors: Zhang
authors: Department of Acute Communicable Disease Control.
authors: Jian
authors: J
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance