title: [Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in penile cancer].
abstract: OBJECTIVE
  To investigate the expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in penile cancer.
  
  
  METHODS
  A total of 96 patients with penile cancer were included, the expression of TS and DPD in tumor tissues were examined by immunohistochemistry method, the relationship of TS and DPD expressions with the clinical characters were also analyzed.
  
  
  RESULTS
  The expression of TS and DPD in penile cancer tissue were 41. 67% (40/96) and 33. 33% (32/96) respectively. There was a positive correlation between TS and DPD expression (Pearson C= 0. 362, P<0. 01). DPD was found to be more expressed in non-smoking patients (P = 0. 040).
  
  
  CONCLUSIONS
  TS and DPD were moderately expressed in penile cancer and their expressions were positively correlated. This could be helpful for the application of fluorouracil in chemotherapy for the patients with penile cancer.
authors: Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Feng
authors: F
authors: Zhao
authors: Jie
authors: J
authors: Tang
authors: Hong-Feng
authors: HF
authors: Gou
authors: Long-Hao
authors: LH
authors: Li
authors: Hang
authors: H
authors: Dong
authors: Ye
authors: Y
authors: Chen
authors: Ke
authors: K
authors: Cheng
authors: Jing
authors: J
authors: Ding
authors: Xin
authors: X
authors: Chen
authors: Hai-Tao
authors: HT
authors: Men
authors: Ji-Yan
authors: JY
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000378:metabolism*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000201:enzymology*; D013940:Thymidylate Synthase / Q000378:metabolism*
chemical_list: D042943:Dihydrouracil Dehydrogenase (NADP); D013940:Thymidylate Synthase; D005472:Fluorouracil