title: Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients.
abstract: BACKGROUND
  Diabetes increases the risk and severity of atherosclerosis. Adropin, a metabolic homeostasis-related protein, has been implicated in the maintenance of metabolic homeostasis. We examined the relationship between serum adropin level and angiographic severity of coronary atherosclerosis in diabetic and non-diabetic patients.
  
  
  METHODS
  A total of 392 patients with suspected coronary artery disease, who underwent coronary angiography, were assigned into the type 2 diabetic and non-diabetic groups and also classified into four groups according to the quartiles of adropin level. Venous serum samples were collected for adropin measurement by enzyme-linked immunosorbent assay and for biochemistry assay. The angiographic severity of coronary atherosclerosis was assessed by Gensini, Friesinger, and SYNTAX scores.
  
  
  RESULTS
  Compared with non-diabetic patients, diabetic patients had lower serum adropin level and higher Gensini, Friesinger and SYNTAX scores (all p<0.001). Serum adropin level was inversely correlated with the Gensini, Friesinger and SYNTAX scores (rs=-0.389, -0.390 and -0.386, respectively, all p<0.001) among all patients. Low adropin level was an independent predictor of clinically relevant coronary atherosclerosis (SYNTAX score >11), both in diabetic patients [odds ratio (OR) 0.66, 95% confidence interval (CI) 0.53-0.83; p<0.001] and in non-diabetic patients (OR 0.51, 95% CI 0.35-0.74; p<0.001).
  
  
  CONCLUSIONS
  Serum adropin level was significantly lower in type 2 diabetic patients than in non-diabetic patients and was inversely and independently associated with angiographic severity of coronary atherosclerosis, suggesting that serum adropin serves as a novel predictor of coronary atherosclerosis.
authors: Lingzhen
authors: L
authors: Wu
authors: Jun
authors: J
authors: Fang
authors: Lianglong
authors: L
authors: Chen
authors: Ziwen
authors: Z
authors: Zhao
authors: Yukun
authors: Y
authors: Luo
authors: Chaogui
authors: C
authors: Lin
authors: Lin
authors: L
authors: Fan
mesh_terms: D000368:Aged; D001798:Blood Proteins / Q000032:analysis*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010455:Peptides / Q000032:analysis*; D011859:Radiography
chemical_list: D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides