title: Molecular characterization of chicken-derived genotype VIId Newcastle disease virus isolates in China during 2005-2012 reveals a new length in hemagglutinin-neuraminidase.
abstract: Newcastle disease (ND) is one of the most important diseases of poultry, and causes severe economic losses in the global poultry industry. Although all Newcastle disease virus (NDV) isolates belong to a single serotype, significant genetic diversity has been described between different NDV isolates. Here, we report the molecular characterization of 23 virulent genotype VIId NDV isolates of class II circulating in China. Phylogenetic construction and analysis revealed the existence of distinctly genomic and amino acid differences that clearly distinguished these isolates from other typical NDV genotypes and vaccine strains. We also report a new 582-amino-acid hemagglutinin-neuraminidase in genotype VII NDV strains. This is believed to be the first study to investigate systematically the most predominant NDV strains, and provides more information on the genetic nature of genotype VIId NDV of class II circulating in China.
authors: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
authors: Yuan-Yuan
authors: YY
authors: Zhang
authors: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
authors: Meng-Yu
authors: MY
authors: Shao
authors: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
authors: Xiao-Hui
authors: XH
authors: Yu
authors: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
authors: Jing
authors: J
authors: Zhao
authors: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China. Electronic address: zhanggz@cau.edu.cn.
authors: Guo-Zhong
authors: GZ
authors: Zhang
mesh_terms: D000818:Animals; D002645:Chickens; D002681:China; D014644:Genetic Variation; D015707:HN Protein / Q000235:genetics*; D006388:Hemagglutinins / Q000235:genetics; D009439:Neuraminidase / Q000235:genetics; D009521:Newcastle Disease / Q000821:virology*; D009522:Newcastle disease virus / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D015707:HN Protein; D006388:Hemagglutinins; D014764:Viral Proteins; D009439:Neuraminidase
keywords: Chicken; Genotype; Newcastle disease virus; Phylogenetic analysis