title: Leukocytes and systemic inflammatory response syndrome as prognostic factors in pulmonary embolism patients.
abstract: BACKGROUND
  Hemodynamic status and cardiac function are important factors for predicting pulmonary embolism (PE) prognosis. Although inflammation is considered a risk factor for deep vein thrombosis, the prognostic significance of both systemic inflammatory response syndrome (SIRS) and leukocytosis has not been elucidated. This study evaluates PE prognostic factors, including SIRS and leukocytes.
  
  
  METHODS
  This retrospective cohort study included 667 PE patients. Risk evaluation included SIRS and leukocytosis. A prediction model was developed based on independent predictors of 30-day mortality.
  
  
  RESULTS
  Fifty-seven patients (8.5%) died within 30 days of PE. Multivariate analysis showed that SIRS satisfying the WBC criteria (odds ratio [OR], 2.8; 95% confidence interval [CI], 1.5-5.4), altered mental status (OR, 4.0; 95% CI, 1.8-8.7), shock (OR, 2.6; 95% CI, 1.0-7.1), and right-to-left ventricle diameter ratio (OR, 1.7; 95% CI, 1.0-2.8) were associated with 30-day mortality. SIRS criteria, including body temperature (OR, 4.6; 95% CI, 1.4-14.8), heart rate (OR, 2.0; 95% CI, 1.1-3.6), respiratory rate (OR, 2.5; 95% CI, 1.4-4.6), and white blood cells (WBC) count (OR, 1.9; 95% CI, 1.2-3.5) predicted short-term mortality following PE. The area under the receiver operating characteristic curve for the prognostic model performance was 0.76 (95% CI, 0.66-0.85); pulmonary embolism severity index (PESI) and PESI + WBC count were 0.72 (95% CI, 0.68-0.75) and 0.76 (95% CI, 0.72-0.79, P < 0.001 versus PESI), respectively.
  
  
  CONCLUSIONS
  Leukocytosis and SIRS are important factors in determining short-term outcomes in PE patients.
authors: Jun Yeon
authors: JY
authors: Jo
authors: Mi Young
authors: MY
authors: Lee
authors: Jin Wook
authors: JW
authors: Lee
authors: Byung Hak
authors: BH
authors: Rho
authors: Pulmonary Unit, Department of Internal Medicine, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea. wichoi@dsmc.or.kr.
authors: Won-Il
authors: WI
authors: Choi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001831:Body Temperature; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes; D007964:Leukocytosis / Q000150:complications*; D008297:Male; D001523:Mental Disorders / Q000150:complications; D008875:Middle Aged; D008954:Models, Biological; D011379:Prognosis; D011655:Pulmonary Embolism / Q000150:complications / Q000401:mortality*; D012372:ROC Curve; D056152:Respiratory Rate; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012769:Shock / Q000150:complications; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications* / Q000503:physiopathology