title: A comparative study on the effects of excess iodine and herbs with excess iodine on thyroid oxidative stress in iodine-deficient rats.
abstract: This study aimed to compare the effect of excess iodine and herbs with excess iodine on treating iodine deficiency-induced goiter from the perspective of oxidative stress and to measure selenium values in Chinese herbs. One hundred twenty 4-week-old Wistar rats were selected and randomly divided into four groups after inducing iodine-deficiency goiter: normal control group (NC), model control group (MC), iodine excess group (IE), and herbs with iodine excess group (HIE). The activities of oxidative enzymes and levels of oxidative products were measured using biochemical tests. The expression of 4-hydroxynonenal (4-HNE) in the thyroid was detected by immunohistochemistry and the expression of peroxiredoxin 5 (PRDX5) by the Western blot and immunohistochemistry. Selenium values in iodine-excessive herbs were measured by hydride generation-atomic fluorescence spectrometry. The herbs with iodine excess were tested to contain rich selenium. The activities of superoxide dismutase (SOD) and PRDX5 increased markedly, and the values of malondialdehyde (MDA) and 4-HNE decreased significantly in the HIE group. In conclusion, compared with excess iodine, herbs with excess iodine damaged thyroid follicular cells less, which may be related to the increase of antioxidant capacity and rich selenium values in iodine-excessive herbs.
authors: Chronic Disease Dept. of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No.72 Chongshan East Rd., Shenyang, 110032, China, gaotianshu67@163.com.
authors: Tianshu
authors: T
authors: Gao
authors: Rui
authors: R
authors: Shi
authors: Tengche
authors: T
authors: Qi
authors: Huisi
authors: H
authors: Yin
authors: Lan
authors: L
authors: Mei
authors: Xiaoqing
authors: X
authors: Han
authors: Peng
authors: P
authors: Cui
mesh_terms: D000447:Aldehydes / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006042:Goiter / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000473:pathology; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission; D018384:Oxidative Stress / Q000187:drug effects*; D054464:Peroxiredoxins / Q000378:metabolism; D028321:Plant Preparations / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012624:Seaweed / Q000737:chemistry; D012643:Selenium / Q000378:metabolism; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D028321:Plant Preparations; D007455:Iodine; D054464:Peroxiredoxins; D012643:Selenium; C027576:4-hydroxy-2-nonenal