title: Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits.
abstract: OBJECTIVE
  To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME).
  
  
  METHODS
  Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min.
  
  
  RESULTS
  There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions.
  
  
  CONCLUSIONS
  Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.
authors: Cristian Durço
authors: CD
authors: Paço
authors: Matheus Fachini
authors: MF
authors: Vane
authors: Rafael Bicarato de
authors: RB
authors: Andrade
authors: Maria Aparecida
authors: MA
authors: Domingues
authors: Lidia Raquel de
authors: LR
authors: Carvalho
authors: Daniela Carvalho
authors: DC
authors: dos Santos
authors: Regina Kiomi
authors: RK
authors: Takahira
authors: Norma Sueli Pinheiro
authors: NS
authors: Modolo
authors: Luiz Antonio
authors: LA
authors: Vane
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D016207:Cytokines / Q000032:analysis; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000293:injuries; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D006439:Hemodynamics; D007262:Infusions, Intravenous; D046529:Microscopy, Electron, Transmission; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D016207:Cytokines; D005217:Fat Emulsions, Intravenous; D015742:Propofol