title: Teaching an old dog new tricks: drug repositioning in small cell lung cancer.
abstract: Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.
authors: 1Departments of Bioinformatics and Computational Biology and 2Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Jing
authors: J
authors: Wang
authors: Lauren Averett
authors: LA
authors: Byers
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D058492:Drug Repositioning; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D018358:Neuroendocrine Tumors / Q000188:drug therapy*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000970:Antineoplastic Agents; D043562:Receptors, G-Protein-Coupled