title: Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model.
abstract: BACKGROUND
  Bortezomib is an anti-neoplastic drug acting against multiple myeloma but its use is associated with the onset of painful peripheral neuropathy. Tumor necrosis factor-α (TNFα) is associated with the development of neuropathic pain; several models have shown that the inactivation of TNFα leads to a reduction in pain stimuli perception. The aim of the present study was to analyze if the administration of an antibody against TNFα is able to prevent the development of bortezomib-induced neuropathic pain.
  
  
  METHODS
  Nerve conduction velocity was measured and a histopathological examination was performed to assess the extent of peripheral neuropathy. To study the onset of painful neuropathy, the response to mechanical or thermal stimuli was evaluated.
  
  
  RESULTS
  This study demonstrated that co-administration of an antibody against TNFα is able to prevent allodynia induced by bortezomib but does not reduce neuropathy.
  
  
  CONCLUSIONS
  Targeting TNFα might be useful in limiting patients' discomfort during bortezomib therapy.
authors: University of Milano Bicocca, via Cadore 48, 20900 Monza (MB), Italy. alessia.chiorazzi@unimib.it.
authors: Alessia
authors: A
authors: Chiorazzi
authors: Annalisa
authors: A
authors: Canta
authors: Cristina
authors: C
authors: Meregalli
authors: Valentina
authors: V
authors: Carozzi
authors: Barbara
authors: B
authors: Sala
authors: Norberto
authors: N
authors: Oggioni
authors: Johan
authors: J
authors: Monbaliu
authors: Helgi
authors: H
authors: VAN DE Velde
authors: Guido
authors: G
authors: Cavaletti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000139:chemically induced / Q000517:prevention & control*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D014409:Tumor Necrosis Factor-alpha; D000069286:Bortezomib
keywords: Bortezomib-induced neuropathy; allodynia; anti-TNFα; tumor necrosis factor-α