title: Stimuli-responsive biodegradable poly(methacrylic acid) based nanocapsules for ultrasound traced and triggered drug delivery system.
abstract: Ultrasound contrast agents (UCAs) have been investigated for echogenic intravenous drug delivery system. Due to the traditional UCAs with overlarge size (micro-scale), their reluctant accumulation in target organs and the instability have presented severe obstacles to the accurate response to the ultrasound and severely limited their further clinical application. Furthermore, elimination of drug carriers from the biologic system after their carrying out the diagnostic or therapeutic functions is one important aspect to be considered. The drug carriers with large sizes, avoiding renal filtration, will lead to increasing toxicity. In this present paper, we design and develop a new type of triple-stimuli responsive (ultrasound/pH/GSH) biodegradable nanocapsules, in which fill up with perfluorohexane, and the DOX-loaded PMAA with disulfide crosslinking forms the wall. These soft nanocapsules with uniform size of 300 nm can easily enter the tumor tissues via EPR effects. The PMAA shell has high DOX-loading content (36 wt%) and great drug loading efficiency (93.5%), the PFH filled can effectively enhance US imaging signal through acoustic droplet vaporization (ADV), ensuring diagnostic and image-guided therapeutic applications. What is more, the disulfide-crosslinked PMAA shell is biodegradable and thus safe for normal organisms. These merits enabled us optimize the balance of diagnostic, therapeutic and biodegradable functionalities in a multifunctional theranostic nanoplatform.
authors: State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
authors: Peng
authors: P
authors: Yang
authors: State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
authors: Dian
authors: D
authors: Li
authors: State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
authors: Sha
authors: S
authors: Jin
authors: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200092, China.
authors: Jing
authors: J
authors: Ding
authors: State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
authors: Jia
authors: J
authors: Guo
authors: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200092, China.
authors: Weibin
authors: W
authors: Shi
authors: State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China. Electronic address: ccwang@fudan.edu.cn.
authors: Changchun
authors: C
authors: Wang
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D005466:Fluorocarbons / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D053769:Nanocapsules / Q000737:chemistry* / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D011109:Polymethacrylic Acids / Q000737:chemistry*; D059005:Topoisomerase II Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D014465:Ultrasonics
chemical_list: D005466:Fluorocarbons; D053769:Nanocapsules; D011109:Polymethacrylic Acids; D059005:Topoisomerase II Inhibitors; C030613:polymethacrylic acid; D004317:Doxorubicin; C078626:perflexane
keywords: Biodegradable; Drug delivery; Imaging; Nanocapsule; Ultrasound/pH/GSH responsive