title: Contra-insular effect of calcitonin on glucose metabolism.
abstract: We studied the effects of Russian preparation of porcine calcitonin (Calcitrinum, 1 U/100 g) on the level of glucose and total calcium, glycogen concentration in the liver, and glucose consumption by the muscle and adipose tissues in vivo and in vitro. The basal level of insulin and secretion of insulin in the dynamics of glucose tolerance test were studied after treatment with calcitonin. In addition to hypocalcemic effect, this substance produced significant hyperglycemic effects, decreased glycogen amount in the liver, inhibited insulin-induced glucose consumption by muscular and adipose tissues in vivo and in vitro, slowed down insulin secretion during glucose load, and impaired glucose tolerance. Thus, calcitonin had contra-insular effects on glucose metabolism.
authors: State Scientific Center of the Russian Federation Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. butalana07@list.ru.
authors: S S
authors: SS
authors: Moisa
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002116:Calcitonin / Q000008:administration & dosage*; D002118:Calcium / Q000032:analysis; D005947:Glucose / Q000032:analysis / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000032:analysis; D050261:Glycogenolysis / Q000187:drug effects; D006943:Hyperglycemia / Q000139:chemically induced; D006996:Hypocalcemia / Q000139:chemically induced; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism; D000078790:Insulin Secretion; D008099:Liver / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D050071:Bone Density Conservation Agents; D007328:Insulin; D006003:Glycogen; D002116:Calcitonin; D005947:Glucose; D002118:Calcium