title: A study on anti-tumour effect of Solanum lyratum Thunb. extract in S₁₈₀ tumour-bearing mice.
abstract: The objective of the study was to investigate the anti-tumour effect of ethanol extract of Solanum lyratum Thunb. in S₁₈₀ tumour-bearing mice, and to preliminarily explore its mechanism of action.
  
  
  METHODS
  Mice were made into S₁₈₀ solid tumour model, grouped and administered. Tumour inhibition rate was measured by harvesting the tumours. Serum IL-2, TNF-a contents were measured by taking blood samples, and thymus index and spleen index were measured by harvesting the thymus and spleen. The results showed that the Solanum lyratum Thunb. extract had certain tumour inhibitory effect, which can elevate the serum IL-2, TNF-a contents, and increase the thymus and spleen indices to a certain extent. The study concluded that Solanum lyratum Thunb. extract has certain in vivo anti-tumour effect which may be exerted through enhancing the body immunity.
authors: Medical Oncology Department of PLA General Hospital, Beijing, China.
authors: Yin
authors: Y
authors: Guan
authors: Hong
authors: H
authors: Zhao
authors: Xiang
authors: X
authors: Yan
authors: Jing
authors: J
authors: Meng
authors: Weilan
authors: W
authors: Wang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood*; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D032322:Solanum; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016207:Cytokines; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha
keywords: S180 sarcoma; Solanum lyratum Thunb.; tumour inhibition rate