title: Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines.
abstract: OBJECTIVE
  Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor.
  
  
  METHODS
  L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubicin against A549 (adenocarcinomic human alveolar basal epithelial cells) and HT29 (human colonic adenocarcinoma) cell lines by MTT assay.
  
  
  RESULTS
  L778123 showed weak cytotoxic activity with IC50 of 100 and 125 for A549 and HT-29 cell lines, respectively. The combination of doxorubicin and L778123 can decrease IC50 of doxorubicin in both cell lines significantly.
  
  
  CONCLUSIONS
  It can be concluded that L778, 123 can be a good agent for combination therapy.
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Saeed
authors: S
authors: Ghasemi
authors: Soodabeh
authors: S
authors: Davaran
authors: Simin
authors: S
authors: Sharifi
authors: Davoud
authors: D
authors: Asgari
authors: Ali
authors: A
authors: Abdollahi
authors: Javid
authors: J
authors: Shahbazi Mojarrad
keywords: Combination therapy; Farnesyltransferase inhibitor; L-778123; MTT assay