title: Cancer-associated myositis: a 35-year retrospective study of a monocentric cohort.
abstract: This study is aimed at retrospectively studying cancer-associated inflammatory myopathies (CAM) in a cohort of patients with inflammatory myopathies. CAM were diagnosed if the tumor was diagnosed 2 years before or after disease onset. One hundred and sixty-two patients were included, 27 (17 %) had CAM. A significant association was observed between CAM and dermatomyositis (DM), older age and dysphagia at disease onset. CAM have lower creatine kinase (CK) levels at onset and a low prevalence of autoantibodies. In conclusion, the association of male sex, older age, DM, dysphagia at onset, lower CK, and autoantibodies negativity carries a high suspicion of CAM.
authors: Rheumatology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy, rneri@int.med.unipi.it.
authors: Rossella
authors: R
authors: Neri
authors: Simone
authors: S
authors: Barsotti
authors: Barsotti
authors: B
authors: Simone
authors: Valentina
authors: V
authors: Iacopetti
authors: Giacomo
authors: G
authors: Iacopetti
authors: Pasquale
authors: P
authors: Pepe
authors: Anna
authors: A
authors: d'Ascanio
authors: Antonio Gaetano
authors: AG
authors: Tavoni
authors: Marta
authors: M
authors: Mosca
authors: Stefano
authors: S
authors: Bombardieri
mesh_terms: D000367:Age Factors; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D003680:Deglutition Disorders / Q000453:epidemiology; D003882:Dermatomyositis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D003402:Creatine Kinase