title: Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.
abstract: A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.
authors: Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
authors: Sarah C
authors: SC
authors: Zimmermann
authors: Joshua M
authors: JM
authors: Sadler
authors: Graciela
authors: G
authors: Andrei
authors: Robert
authors: R
authors: Snoeck
authors: Jan
authors: J
authors: Balzarini
authors: Katherine L
authors: KL
authors: Seley-Radtke