title: Association of soluble receptor for advanced glycation end products levels with hypertensive albuminuria.
abstract: OBJECTIVE
  Soluble receptor for advanced glycation end products (sRAGE) levels have been found to be decreased in chronic inflammatory diseases including atherosclerosis, hypertension and renal failure. This study evaluated the relationship between sRAGE concentrations and urinary albumin excretion in patients with essential hypertension.
  
  
  METHODS
  A total of 200 consecutive patients with essential hypertension were enrolled and were divided into 3 groups.
  
  
  RESULTS
  Plasma sRAGE levels were significantly lower in hypertensive patients with micro- or macroalbuminuria compared with those in hypertensive patients with normoalbuminuria, and the values in the macroalbuminuria group were even lower than in the microalbuminuria group (128.6±24.2, 244.6±37.6±313.6±30.7 pg/ml, respectively). In addition, plasma sRAGE level was an independent determinant of log urinary albumin excretion in patients with essential hypertension (β=-0.267, P<0.05).
  
  
  CONCLUSIONS
  sRAGE may play a role in the pathogenic processes that link albuminuria, chronic inflammation and oxidative stress in hypertensive patients.
authors: Huan
authors: H
authors: Zheng
authors: Lingyan
authors: L
authors: Yuan
authors: Nanzi
authors: N
authors: Xie
authors: Huifeng
authors: H
authors: Xu
authors: Xiaoyun
authors: X
authors: Xie
authors: 389 Xincun Road, Tongji Hospital Affiliated to Tongji University, Shanghai, China, 200065. lmfc2013@163.com.
authors: Ming
authors: M
authors: Luo
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*
chemical_list: C000593871:AGER protein, human; D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products