title: Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform.
abstract: Convincing epidemiological data suggest an inverse association between cancer and neurodegeneration, including Alzheimer's disease (AD). Since both AD and cancer are characterized by abnormal, but opposing cellular behavior, i.e., increased cell death in AD while excessive cell growth occurs in cancer, this motivates us to initiate the study into unraveling the shared genes and cell signaling pathways linking AD and glioblastoma multiform (GBM). In this study, a comprehensive bioinformatics analysis on clinical microarray datasets of 1,091 GBM and 524 AD cohorts was performed. Significant genes and pathways were identified from the bioinformatics analyses - in particular ERK/MAPK signaling, up-regulated in GBM and Angiopoietin Signaling pathway, reciprocally up-regulated in AD - connecting GBM and AD (P < 0.001), were investigated in details for their roles in GBM growth in an AD environment. Our results showed that suppression of GBM growth in an AD background was mediated by the ERK-AKT-p21-cell cycle pathway and anti-angiogenesis pathway.
authors: 1] Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030 [2].
authors: Timothy
authors: T
authors: Liu
authors: Ding
authors: D
authors: Ren
authors: Xiaoping
authors: X
authors: Zhu
authors: Zheng
authors: Z
authors: Yin
authors: Guangxu
authors: G
authors: Jin
authors: Zhen
authors: Z
authors: Zhao
authors: Daniel
authors: D
authors: Robinson
authors: Xuping
authors: X
authors: Li
authors: Kelvin
authors: K
authors: Wong
authors: Kemi
authors: K
authors: Cui
authors: Hong
authors: H
authors: Zhao
authors: Stephen T C
authors: ST
authors: Wong
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D016022:Case-Control Studies; D002460:Cell Line; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020935:MAP Kinase Signaling System; D051379:Mice; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D016229:Amyloid beta-Peptides; D051057:Proto-Oncogene Proteins c-akt