title: Brain metastases of choriocarcinoma--a report on two cases.
abstract: BACKGROUND
  Gestational trophoblastic diseases (GTD) are a spectrum of tumors with a various of biological behavior and potential for metastases. It consists of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Choriocarcinoma presents a very aggressive tumor with high malignant potential.
  
  
  METHODS
  We presented the two cases of choriocarcinoma with brain metastases. The first one was manifested by neurological deterioration as the first sign of metastasis, while the second patient had firstly metrorrhagia and in the further couse neurological disturbances that suggested the presence of brain tumor. In both cases we applied a combined treatment of surgery, chemotherapy and radiation therapy. Both patient survived with high quality of life.
  
  
  CONCLUSIONS
  A successful outcome of brain metastases of choriocarcinoma was obtained by the use of a combined treatment of surgery, chemotherapy and radiation therapy. In cases of young women with brain metastases, gynecological malignancy should be always considered.
authors: Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Vera
authors: V
authors: Milenković
authors: Biljana
authors: B
authors: Lazović
authors: Ljiljana
authors: L
authors: Mirković
authors: Danica
authors: D
authors: Grujicić
authors: Radmila
authors: R
authors: Sparić
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000556:secondary / Q000628:therapy; D031954:Choriocarcinoma, Non-gestational / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D011859:Radiography; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents