title: Association of X-ray repair cross-complementing-6 genotypes with childhood leukemia.
abstract: BACKGROUND
  The Non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs), and has been found to be involved in the carcinogenesis of many types of cancers including oral, prostate, breast and bladder cancer. However, the contribution of XRCC6 to childhood leukemia has yet to be studied. In the present study, we investigated the association of XRCC6 genotypes with the risk of childhood leukemia.
  
  
  METHODS
  Two hundred and sixty-six patients with childhood leukemia and an equal number of age-matched healthy controls recruited in Central Taiwan, were genotyped investigating these polymorphisms' association with childhood leukemia.
  
  
  RESULTS
  As for XRCC6 promoter T-991C, patients carrying the TC genotype had a significantly increased risk of childhood leukemia compared with the TT wild-type genotype [odds ratio (OR)=2.30, 95% confidence interval (CI)=1.38-3.84, p=0.0047]. Meanwhile, the genotypes of XRCC6 promoter C-57G, A-31G and intron3 were not statistically associated with childhood leukemia risk.
  
  
  CONCLUSIONS
  Our findings suggest that the XRCC6 genotype could serve as a predictor of childhood leukemia risk and XRCC6 could serve as a target for personalized medicine and therapy.
authors: Terry Fox Cancer Research Laboratory, China Medical University and Hospital, Taichung, Taiwan 40421, Republic of China, sslin@ctust.edu.tw; artbau2@gmail.com.
authors: Jen-Sheng
authors: JS
authors: Pei
authors: Yi-Min
authors: YM
authors: Lee
authors: Hsueh-Hsia
authors: HH
authors: Lo
authors: Yuan-Nian
authors: YN
authors: Hsu
authors: Song-Shei
authors: SS
authors: Lin
authors: Da-Tian
authors: DT
authors: Bau
mesh_terms: D034961:Antigens, Nuclear / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D000072200:Ku Autoantigen; D007938:Leukemia / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D034961:Antigens, Nuclear; D017931:DNA Primers; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen
keywords: XRCC6/Ku70; childhood leukemia; genotyping; non-homologous end-joining; polymorphisms