title: Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment.
abstract: Tumor-infiltrating T cells have recently been found to upregulate immunosuppressive pathways, such as programmed cell death protein 1 ligand 1 (PD-L1), in a paracrine fashion on tumor cells, but tumor cell-intrinsic regulation of PD-L1 is another potential mechanism. In this issue of Cancer Discovery, Akbay and colleagues show that signaling via mutant EGF receptor (EGFR) in murine lung tumor cells directly upregulates tumor PD-L1 and that therapeutic blockade of this pathway improves survival in EGFR-driven preclinical models-highlighting the dynamic interplay and therapeutic opportunities of cancer cell biology and immune biology.
authors: 1Abramson Family Cancer Research Institute; 2Abramson Cancer Center; 3Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Andrew J
authors: AJ
authors: Rech
authors: Robert H
authors: RH
authors: Vonderheide
mesh_terms: D000818:Animals; D060890:B7-H1 Antigen / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*; D019139:Tumor Escape
chemical_list: D060890:B7-H1 Antigen; D016207:Cytokines; D061026:Programmed Cell Death 1 Receptor; D066246:ErbB Receptors