title: [Aberrant right subclavian artery (arteria lusoria) and the risk for trisomy 21. Retrospective study of 11,479 fetopathological examinations].
abstract: OBJECTIVE
  The aberrant right subclavian artery is a malformation of the aortic arch present at less than 2 % of the individuals in the general population. This incidence is higher in trisomy 21, making it possible use the aberrant right subclavian artery as a prenatal marker of trisomy 21.
  
  
  METHODS
  This work, which relates to a series of 11,479 consecutive fetal autopsies aims to measure the force of association between the aberrant right subclavian artery and trisomy 21, to confront our results with the sonographic series previously published and to contribute to assess the place that can have this sign in the echographic screening and the fetopathologic diagnosis of trisomy 21.
  
  
  RESULTS
  The isolated presence of an aberrant right subclavian artery does not represent an argument sufficient for the indication of a karyotype. But the detection of this anomaly must make pay a special attention in search of other associated signs.
  
  
  CONCLUSIONS
  On the results of this study, the aberrant right subclavian artery has to be considered as a part of the spectrum not only of trisomy 21, but also of many other congenital syndromes.
authors: Unité de pathologie fœtoplacentaire, service d'anatomie pathologique, université Bordeaux-Segalen, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. Electronic address: dominique.carles@sante-aquitaine.net.
authors: D
authors: D
authors: Carles
authors: Unité de pathologie fœtoplacentaire, service d'anatomie pathologique, université Bordeaux-Segalen, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
authors: F
authors: F
authors: Pelluard
authors: Unité de pathologie fœtoplacentaire, service d'anatomie pathologique, université Bordeaux-Segalen, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
authors: G
authors: G
authors: André
authors: Unité de pathologie fœtoplacentaire, service d'anatomie pathologique, université Bordeaux-Segalen, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
authors: N
authors: N
authors: Nocart
authors: Unité de pathologie fœtoplacentaire, service d'anatomie pathologique, université Bordeaux-Segalen, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
authors: F
authors: F
authors: Sauvestre
mesh_terms: D000783:Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D018376:Cardiovascular Abnormalities / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D003680:Deglutition Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D004314:Down Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D013348:Subclavian Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging; D016216:Ultrasonography, Prenatal
keywords: Aberrant subclavian artery; Arteria lusoria; Artère sous-clavière droite aberrante; Congenital polymalformation; Dépistage anténatal; Prenatal diagnosis; Syndromes polymalformatifs; Trisomie 21; Trisomy 21