title: Modigraf administration through jejunostomy in liver transplant recipient: case report.
abstract: We report our experience with a 61-year-old patient with alcoholic and hepatitis C cirrhosis who underwent liver transplantation. On the 3rd postoperative day he presented a mediastinitis secondary to esophageal perforation produced by a Linton tube. An esophagectomy with jejunostomy was performed. Tacrolimus granules for oral suspension (Modigraf) were administered through the jejunostomy. This case report highlights the use of Modigraf and the absence of secondary effects. We observed biochemical parameters during the jejunostomy period. We discuss the administration strategy applied and whether tacrolimus granules for oral suspension by jejunostomy affect the bioavailability and its side effects.
authors: Hepatobiliopancreatic Surgery Unit, General and Digestive Surgery, Virgen del Rocío University Hospitals, Seville, Spain. Electronic address: violeta.camachomarente@gmail.com.
authors: V Camacho
authors: VC
authors: Marente
authors: L M Marin
authors: LM
authors: Gomez
authors: J Gracia
authors: JG
authors: Martinez
authors: C
authors: C
authors: Bernal-Bellido
authors: G
authors: G
authors: Suárez-Artacho
authors: J M
authors: JM
authors: Alamo-Martínez
authors: L
authors: L
authors: Barrera-Pulido
authors: J
authors: J
authors: Serrano-Díaz-Canedo
authors: F J
authors: FJ
authors: Padillo-Ruiz
authors: M A
authors: MA
authors: Gómez-Bravo
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000601:surgery / Q000821:virology; D002626:Chemistry, Pharmaceutical; D004939:Esophageal Perforation / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016629:Esophagectomy; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D007582:Jejunostomy; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000601:surgery / Q000821:virology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D008113:Liver Neoplasms / Q000209:etiology / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008480:Mediastinitis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D008875:Middle Aged; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus