title: LigSearch: a knowledge-based web server to identify likely ligands for a protein target.
abstract: Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.
authors: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England.
authors: Tjaart A P
authors: TA
authors: de Beer
authors: Roman A
authors: RA
authors: Laskowski
authors: Mark-Eugene
authors: ME
authors: Duban
authors: A W Edith
authors: AW
authors: Chan
authors: Wayne F
authors: WF
authors: Anderson
authors: Janet M
authors: JM
authors: Thornton
mesh_terms: D001665:Binding Sites; D062313:Databases, Pharmaceutical; D030562:Databases, Protein; D005103:Expert Systems; D020407:Internet; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D057386:Search Engine; D012984:Software
chemical_list: D008024:Ligands; D011506:Proteins
keywords: LigSearch; ligand prediction