title: Loss of cellular cohesion in cytology composes a special subgroup of breast tumors - analysis of 37 cases.
abstract: OBJECTIVE
  We analyzed smears by fine needle aspiration (FNA) from 37 cases that displayed numerous dissociated cells and correlated the results with histological findings.
  
  
  METHODS
  Between 1996 and 2005, 1,583 patients underwent breast FNA and resection. Loss of cellular cohesion was observed in 37 of these cases.
  
  
  RESULTS
  From the cytological findings, we classified cases into 3 groups according to cell size and shape. Type A: numerous isolated spindle cells with a necrotic background. Four cases were classified into this group (3 cases of intraductal papilloma and 1 case of adenomyoepithelioma). Type B: lymphocytes and large isolated cells such as medullary carcinoma. Five cases were classified into this group [1 case of classic medullary carcinoma, 1 case of ductal carcinoma in situ (DCIS) and 3 cases of invasive carcinoma of no special type (NST)]. Type C: numerous uniform small round cells. Twenty-eight cases were classified into this group (2 cases of lobular carcinoma, 1 case of DCIS, 22 cases of invasive carcinoma NST, and 3 cases of solid papillary carcinoma).
  
  
  CONCLUSIONS
  Numerous isolated cells are sometimes seen in both benign and malignant cytology.
authors: Department of Pathology, Osaka Red Cross Hospital, Osaka, Japan.
authors: Tomoko
authors: T
authors: Wakasa
authors: Misa
authors: M
authors: Nakamura
authors: Tomoko
authors: T
authors: Kagiya
authors: Emiko
authors: E
authors: Taniguchi
authors: Takeo
authors: T
authors: Sakurai
authors: Kennichi
authors: K
authors: Kakudo
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000145:classification* / Q000378:metabolism / Q000473:pathology*; D002448:Cell Adhesion; D003581:Cytodiagnosis / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test
chemical_list: D014408:Biomarkers, Tumor