title: Two new alkaloids from the bulbs of Lycoris sprengeri.
abstract: Two new alkaloids, lycosprenine (1) and 2α-methoxy-6-O-methyllycorenine (2), along with 22 known alkaloids (3-23b), were isolated from the bulb of Lycoris sprengeri. Their structures were elucidated on the basis of spectral analysis and by comparison of the spectroscopic data with those of known compounds. Selected compounds (1-3 and 6-9) were tested for their neuroprotective activities against H2O2-, CoCl2- and Aβ25-35-induced SH-SY5Y cell injury, most of which exhibited neuroprotective effects of different degrees.
authors: a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Wuhan , 430030 , China.
authors: Wen-Ming
authors: WM
authors: Wu
authors: Yun-Yun
authors: YY
authors: Zhu
authors: Hao-Ran
authors: HR
authors: Li
authors: Heng-Yi
authors: HY
authors: Yu
authors: Peng
authors: P
authors: Zhang
authors: Hui-Fang
authors: HF
authors: Pi
authors: Han-Li
authors: HL
authors: Ruan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D031426:Lycoris / Q000737:chemistry*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: C587153:2alpha-methoxy-6-O-methyllycorenine; D000470:Alkaloids; D018696:Neuroprotective Agents; C587152:lycosprenine; D006861:Hydrogen Peroxide