title: Integral approach to evaluation of the pathogenic activity of Trypanosoma cruzi clones as exemplified by the Mexican strain.
abstract: Comparative histopathological study and analysis of parasite load in different muscle groups were carried out in BALB/c mice during the acute phase of Chagas disease. Activities of C104 clone of T. cruzi strain TPAP/MX/2002/Albarrada and the parental strain were compared. Panoramic 2D-microscopy imaging of sample surface was used and quantitative analysis of parasitism and pathologic damage was performed. The infection rates in various muscle groups were as follows: myocardium=abdominal muscles=lumbar muscles=femoral muscles<--diaphragm for the clone and myocardium¬abdominal muscles=lumbar muscles=femoral muscles-->diaphragm for the parental strain.
authors: Medical Faculty, Faculty of Telematics, University of Colima, Colima, Mexico; Medical Faculty, the Russian University of Peoples' Friendship, Moscow, Russia; Departamento de Immunologia Instituto de Investigaciones Biomedicas, UNAM (U.N.A.M.), Mexico D. F., Mexico; Center of Biomedical Investigations, University of Colima, Colima, Mexico. melnik@ucol.mx.
authors: Valery
authors: V
authors: Melnikov
authors: Francisco
authors: F
authors: Espinoza-Gomez
authors: Oscar
authors: O
authors: Newton-Sanchez
authors: Ivan
authors: I
authors: Delgado-Ensiso
authors: Oswal Antonio
authors: OA
authors: Montesinos-Lopez
authors: M V
authors: MV
authors: Dalin
authors: Bertha
authors: B
authors: Espinoza
authors: Ignacio
authors: I
authors: Martinez
authors: L A
authors: LA
authors: Sheklakova
authors: Oksana
authors: O
authors: Dobrovinskaya
authors: L P
authors: LP
authors: Karpenko
mesh_terms: D000009:Abdominal Muscles / Q000469:parasitology; D000818:Animals; D014355:Chagas Disease / Q000469:parasitology*; D003964:Diaphragm / Q000469:parasitology; D006321:Heart / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D009220:Myositis / Q000469:parasitology; D009928:Organ Specificity; D059208:Parasite Load; D014349:Trypanosoma cruzi / Q000235:genetics / Q000472:pathogenicity*