title: Absence of occult HCV infection in patients experiencing an immunodepression condition.
abstract: The aim of our study was to evaluate the presence of occult HCV infection in two settings of patients experiencing immunosuppression: patients with Human Immunodeficiency Virus (HIV) infection and those with onco-haematological disease. Sixty consecutive HIV-positive/anti-HCV-negative/HCV RNA-negative patients (HIV group) and 32 consecutive anti-HCV/HCV RNA negative patients with an onco-haematological disease first undergoing chemotherapy (Onco-haematological group) were enrolled. HCV-RNA was sought by real time RT-PCR in plasma and Peripheral Blood Mononuclear Cell (PBMC) samples obtained at enrolment and during follow-up, in the patients in the HIV group every three months and in those in the onco-haematological group at months 1 and 3 during chemotherapy and then every three months after treatment discontinuation. No plasma or PBMC sample collected at enrolment and during the follow-up in the HIV and onco-haematological groups was HCV RNA positive. The results of this study rule out the existence of occult HCV infection in patients with strong immunosuppression due to different conditions, HIV infection and onco-haematological diseases.
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Mariantonietta
authors: M
authors: Pisaturo
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Salvatore
authors: S
authors: Guastafierro
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Pietro
authors: P
authors: Filippini
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Gilda
authors: G
authors: Tonziello
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Antonello
authors: A
authors: Sica
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Filomena
authors: F
authors: Di Martino
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Caterina
authors: C
authors: Sagnelli
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Maria Giovanna
authors: MG
authors: Ferrara
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Salvatore
authors: S
authors: Martini
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Domenico
authors: D
authors: Cozzolino
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Evangelista
authors: E
authors: Sagnelli
authors: Department of Mental and Public Health, Section of Infectious Diseases; Haematology Unit; Department of Clinical and Experimental Medicine and Surgery F. Magrassi A. Lanzara; Department of Internal Medicine, Unit of Internal Medicine, Second University of Naples; Division of Infectious Diseases, Azienda Ospedaliera Santa Anna and San Sebastiano di Caserta, Italy.
authors: Nicola
authors: N
authors: Coppola
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D019337:Hematologic Neoplasms / Q000150:complications* / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult