title: Analysis of 27 vascular-related proteins reveals that NT-proBNP is a potential biomarker for Alzheimer's disease and mild cognitive impairment: a pilot-study.
abstract: Alzheimer's disease (AD) is a severe neurodegenerative disease. Cerebrovascular changes often accompany AD-related pathology. Despite a considerable progress in the diagnostic accuracy of AD, no blood biomarkers have been established so far. The aim of the present study was to search for changes in plasma levels of 27 vascular-related proteins of healthy controls, patients with mild cognitive impairment (MCI) and AD. In a sample of 80 participants we showed that out of these 27 proteins, six proteins were slightly changed (up to 1.5×) in AD (alpha2-macroglobulin, apolipoprotein-A1, plasminogen activator inhibitor, RAGE, Tissue Inhibitors of Metalloproteinases-1 and Trombospondin-2) and one marker (serum amyloid A) was enhanced up to 6× but with a very high variance. However, N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly enhanced both in MCI and AD patients (1.9×). In a second analysis of a sample of 110 subjects including younger healthy controls, we confirmed that NT-proBNP has the potential to be a stable candidate protein for both diagnosis and AD disease progression.
authors: Department of Psychiatry and Psychotherapy A, Landeskrankenhaus Hall, Austria.
authors: Josef
authors: J
authors: Marksteiner
authors: Department of Psychiatry and Psychotherapy A, Landeskrankenhaus Hall, Austria.
authors: Douglas
authors: D
authors: Imarhiagbe
authors: Memory Clinics, Department of Psychiatry and Psychotherapy Innsbruck, Innsbruck, Austria.
authors: Michaela
authors: M
authors: Defrancesco
authors: Memory Clinics, Department of Psychiatry and Psychotherapy Innsbruck, Innsbruck, Austria.
authors: Eberhard A
authors: EA
authors: Deisenhammer
authors: Laboratory for Experimental Alzheimer's Disease, Department of Psychiatry and Psychotherapy Innsbruck, Innsbruck, Austria.
authors: Georg
authors: G
authors: Kemmler
authors: Laboratory for Experimental Alzheimer's Disease, Department of Psychiatry and Psychotherapy Innsbruck, Innsbruck, Austria. Electronic address: christian.humpel@i-med.ac.at.
authors: Christian
authors: C
authors: Humpel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood / Q000175:diagnosis*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009483:Neuropsychological Tests; D018579:Patient Selection; D010446:Peptide Fragments / Q000097:blood*; D010865:Pilot Projects; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Alzheimer; Biomarker; Diagnosis; Mild cognitive impairment; Multiplex ELISA; NT-proBNP; Plasma