title: Highly efficient and versatile synthesis of lactams and N-heterocycles via Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions.
abstract: The discovery and development of an efficient and versatile method for the synthesis of N-substituted lactams is described. Pyrrolindinones, piperidones, and structurally related heterocycles were formed by Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions of corresponding nitrogen substituted ketoamides in good yields.
authors: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, P.R. China.
authors: Jianguo
authors: J
authors: Qi
authors: Chenbin
authors: C
authors: Sun
authors: Yulin
authors: Y
authors: Tian
authors: Xiaojian
authors: X
authors: Wang
authors: Gang
authors: G
authors: Li
authors: Qiong
authors: Q
authors: Xiao
authors: Dali
authors: D
authors: Yin
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D007477:Ions / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds; D007477:Ions; D007769:Lactams; D008698:Mesylates; C012077:trifluoromethanesulfonic acid