title: [The analysis of concentration of cyclosporine A in blood using liquid chromatographic mass spectrometry].
abstract: The method of analysis of concentration of immunosuppressant of cyclosporine A in whole blood was developed. The highly effective liquid chromatography with mass spectrometric detection was applied using device of "ionic trap" type. The optimal conditions of analysis are established. The tryout of method was carried out using blood samples of healthy donors and patients underwent allotransplantation of organs. The comparison was made of the developed method with method of fluorescence polarized immunoassay Abbott TDX applied in clinical diagnostic. The higher selectivity of the proposed method to cyclosporine A as compared with Abbott TDX was established.
authors: N V
authors: NV
authors: Apanasenko
authors: P V
authors: PV
authors: Kudan
authors: F S
authors: FS
authors: Baranova
authors: V Iu
authors: VIu
authors: Abramov
mesh_terms: D016572:Cyclosporine / Q000493:pharmacokinetics*; D019085:Fluorescent Antibody Technique, Direct / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine