title: [Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease].
abstract: OBJECTIVE
  To assess the association of interleukin 10 (IL10) gene -592C/A polymorphism with morbidity of coronary heart disease in a southern Chinese Han population.
  
  
  METHODS
  Frequencies of various genotypes and alleles for the IL10 -592C/A polymorphism (rs1800872) were determined by the means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in 249 patients and 132 unaffected controls.
  
  
  RESULTS
  The frequencies of both IL10 -592C/A site and different alleles have reached statistical significance (P<0.05) after correcting the difference in clinical data by logistic regression analysis. The risk of coronary heart disease in the patients with A gene (AA+CA) was 2.449 times greater than those without (95%CI:1.214-4.940, P=0.012).
  
  
  CONCLUSIONS
  IL10 gene -592C/A polymorphism is associated with the risk of coronary heart disease. Allele A may be a risk factor for this disease in the studied population.
authors: Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, P.R. China. xlx77471@163.com.
authors: Hu
authors: H
authors: Jin
authors: Yan
authors: Y
authors: Wang
authors: Li-xing
authors: LX
authors: Xu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10