title: Effective cancer cell killing by hydrophobic nanovoid-enhanced cavitation under safe low-energy ultrasound.
abstract: β-Cyclodextrin (β-CD)-capped mesoporous silica nanoparticles with hydrophobic internal nanovoids were prepared and used for effective cancer cell killing in synergistic combination with low-energy ultrasound (≤1.0 W cm(-2) , 1 MHz). The water-dispersible nanoparticles with hydrophobic internal nanovoids can be taken up by cancer cells and subsequently evoke a remarkable cavitation effect under irradiation with mild low-energy ultrasound (≤1.0 W cm(-2) , 1 MHz). A significant cancer cell killing effect was observed in cancer cells and in a mouse xenograft tumor model treated with the nanoagents together with the low-energy ultrasound, showing a distinct dependence on the concentration of nanoagents and ultrasound intensity. By contrast, an antitumor effect was not observed when either low-energy ultrasound or nanoagents were applied alone. These findings are significant as the technique promises a safe, low-cost, and effective treatment for cancer therapy.
authors: The State Key Lab of High Performance Ceramics and Superfine Microstructure, Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050 (P. R. China), Fax: (+86) 2152412632.
authors: Yang
authors: Y
authors: Zhao
authors: Yingchun
authors: Y
authors: Zhu
authors: Jingke
authors: J
authors: Fu
authors: Lianzhou
authors: L
authors: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy*; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D014464:Ultrasonic Therapy; D023041:Xenograft Model Antitumor Assays; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; C031215:betadex
keywords: cancer; cavitation; low-energy ultrasound; mesoporous materials; nanoparticles