title: Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia.
abstract: Nine patients with chronic immune thrombocytopenia and platelet counts <20 × 10(9) /L, with a median age of 7.8 (3.8-15.5) years, received three phases of 10 mcg/kg/dose of intramuscular anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥ 20 × 10(9) /L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available.
authors: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors: Nongnuch
authors: N
authors: Sirachainan
authors: Usanarat
authors: U
authors: Anurathapan
authors: Ampaiwan
authors: A
authors: Chuansumrit
authors: Duantida
authors: D
authors: Songdej
authors: Pakawan
authors: P
authors: Wongwerawattanakoon
authors: Sakara
authors: S
authors: Hutspardol
authors: Pimpun
authors: P
authors: Kitpoka
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007518:Isoantibodies / Q000008:administration & dosage*; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin; D012720:Severity of Illness Index
chemical_list: D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin
keywords: children; chronic immune thrombocytopenia; intramuscular anti-D