title: Is there an appropriate cutoff age for sampling the endometrium in premenopausal bleeding?
abstract: OBJECTIVE
  To determine a cutoff age for endometrial evaluation in premenopausal abnormal uterine bleeding (AUB).
  
  
  METHODS
  Histopathology reports of endometrial sampling performed due to AUB in women aged 50 years or less were reviewed retrospectively. Histopathological findings were categorized into three groups as follows: group 1: hyperplasia without atypia + hyperplasia with atypia + malignancy, group 2: hyperplasia with atypia + malignancy, and group 3: malignancy.
  
  
  RESULTS
  Data from 2,516 patients were analyzed for this study. Overall, 13.5% of patients had endometrial hyperplasia without atypia, 1% of patients had hyperplasia with atypia and 0.6% of patients had malignant disease. Logistic regression revealed a significant difference in the odds ratios of group 1 in the age ranges of 40-45 and 45-50 years compared with <40 years (p = 0.001 and p = 0.01, respectively). There were no significant differences between the age groups for the odds ratio of group 2 and group 3.
  
  
  CONCLUSIONS
  There is no cutoff age for sampling the endometrium in order to detect hyperplasia with atypia and cancer in premenopausal women with AUB. Therefore, the management of AUB should be tailored to each patient regardless of age, incorporating all risk factors for malignant disease.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors: Aytul
authors: A
authors: Corbacioglu Esmer
authors: Ozgur
authors: O
authors: Akbayir
authors: Behiye Pinar Cilesiz
authors: BP
authors: Goksedef
authors: Nermin
authors: N
authors: Gunduz
authors: Songul
authors: S
authors: Kisacık
authors: Hediye
authors: H
authors: Dagdeviren
authors: Birgul
authors: B
authors: Guraslan
authors: Cemal
authors: C
authors: Ark
mesh_terms: D000328:Adult; D000367:Age Factors; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D017697:Premenopause; D015995:Prevalence; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology