title: Establishment of methylation patterns in ES cells.
abstract: After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.
authors: 1] Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel. [2].
authors: Ofra
authors: O
authors: Sabag
authors: 1] Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel. [2].
authors: Ayelet
authors: A
authors: Zamir
authors: 1] Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel. [2].
authors: Ilana
authors: I
authors: Keshet
authors: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.
authors: Merav
authors: M
authors: Hecht
authors: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.
authors: Guy
authors: G
authors: Ludwig
authors: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.
authors: Amalia
authors: A
authors: Tabib
authors: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.
authors: Joshua
authors: J
authors: Moss
authors: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.
authors: Howard
authors: H
authors: Cedar
mesh_terms: D000586:Amination; D000818:Animals; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics; D053595:Embryonic Stem Cells / Q000378:metabolism*; D051379:Mice