title: Synthesis of licochalcone analogues with increased anti-inflammatory activity.
abstract: Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1-6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95μM of IC50 values, respectively.
authors: Department of Chemistry and Institute of Applied Chemistry, Hallym University, Chuncheon 200-702, Republic of Korea.
authors: Si-Jun
authors: SJ
authors: Kim
authors: Department of Chemistry and Institute of Applied Chemistry, Hallym University, Chuncheon 200-702, Republic of Korea.
authors: Cheol Gi
authors: CG
authors: Kim
authors: Department of Chemistry and Institute of Applied Chemistry, Hallym University, Chuncheon 200-702, Republic of Korea.
authors: So-Ra
authors: SR
authors: Yun
authors: Department of Biomedical Science, College of Natural Science, Catholic University of Daegu, Gyeungsan-Si 700-702, Republic of Korea.
authors: Jin-Kyung
authors: JK
authors: Kim
authors: Department of Chemistry and Institute of Applied Chemistry, Hallym University, Chuncheon 200-702, Republic of Korea. Electronic address: jgjun@hallym.ac.kr.
authors: Jong-Gab
authors: JG
authors: Jun
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008407:Mast Cells; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047188:Chalcones; D009569:Nitric Oxide; C541529:licochalcone D; C541528:licochalcone B; C070840:licochalcone A
keywords: IC(50) values of NO production; Licohalcone B; Licohalcone D; [3,3]-Sigmatropic rearrangement; anti-Inflammatory effects