title: Rosiglitazone inhibits HMC-1 cell migration and adhesion through a peroxisome proliferator-activated receptor gamma-dependent mechanism.
abstract: Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response. To investigate a possible role for PPARγ in human mast cells, we studied the effects of a PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells. It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells. In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism.
authors: Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, China. zhangguqin@yahoo.cn.
authors: Guqin
authors: G
authors: Zhang
authors: Jiong
authors: J
authors: Yang
authors: Ping
authors: P
authors: Li
authors: Jie
authors: J
authors: Cao
authors: Hanxiang
authors: H
authors: Nie
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008407:Mast Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D047495:PPAR gamma / Q000096:biosynthesis / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000276:immunology; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D047495:PPAR gamma; D012333:RNA, Messenger; D045162:Thiazolidinediones; D000077154:Rosiglitazone