title: Comparative phenotypic and cytochemical characteristics of lymphocytes of Wistar rats and rats with genetic predisposition to catalepsy after retabolil administration.
abstract: We studied the possibility of using anabolic steroid retabolil injections for complex correction of behavioral and immune parameters in rats with genetic predisposition to catalepsy. Subpopulation composition of lymphoid organ and blood cells was compared in rats with genetic predisposition to catalepsy and Wistar rats after retabolil administration. In rats predisposed to catalepsy, retabolil reduced the total content of thymus cells and increased absolute count of CD8 (+) thymocytes. In Wistar rats, retabolil increased the total cell count and the content of CD4 (+) thymocytes, but reduced the number of CD8 (+) cells. Therefore, changes in the subpopulation composition of thymus cells after retabolil administration were opposite in rats with genetic predisposition to catalepsy and Wistar rats. Retabolil injections reduced the severity of catalepsy response in rats with genetic predisposition. However, the time of freezing in Wistar rats significantly increased under these conditions.
authors: Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. panteleeva@ngs.ru.
authors: N G
authors: NG
authors: Panteleeva
authors: A V
authors: AV
authors: Shurlygina
authors: V A
authors: VA
authors: Trufakin
mesh_terms: D045930:Anabolic Agents / Q000008:administration & dosage*; D000818:Animals; D002375:Catalepsy / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006836:Hydro-Lyases / Q000378:metabolism; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D045930:Anabolic Agents; D009277:Nandrolone; D013385:Succinate Dehydrogenase; D006836:Hydro-Lyases; C045581:lactate dehydratase; D000077603:Nandrolone Decanoate