title: Psoriasis in pregnancy: a review (II).
abstract: Scarce scientific evidence is available to define the precise effects that certain drugs might have on embryonic and fetal development if taken by pregnant women with psoriasis, given the ethical concerns that preclude enrolling such women in clinical trials. The little information on the use of biologics during gestation that has been published is based on retrospective and observational studies, and experience with these drugs in this context in psoriasis is still very limited. The literature seems to suggest that biologic therapy is safe during pregnancy, but there is no certainty. This detailed review of accumulated experience with biologic therapy during pregnancy relies mainly on descriptions of the management of other types of rheumatic disease, although the use of these agents in psoriasis is growing steadily.
authors: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España. Electronic address: v.ruizsalas@hotmail.com.
authors: V
authors: V
authors: Ruiz
authors: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors: E
authors: E
authors: Manubens
authors: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors: L
authors: L
authors: Puig
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000517:prevention & control; D000818:Animals; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001688:Biological Products / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects; D011565:Psoriasis / Q000188:drug therapy*; D018570:Risk Assessment; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha
keywords: Agentes antifactor de necrosis tumoral alfa; Biologic therapy; Embarazo; Pregnancy; Psoriasis; Terapia biológica; Tumor necrosis factor alpha inhibitors