title: The use of imidazolium ionic liquid/copper complex as novel and green catalyst for chemiluminescent detection of folic acid by Mn-doped ZnS nanocrystals.
abstract: A novel chemiluminescence (CL) method using water-soluble Mn-doped ZnS quantum dots (QDs) as CL emitter is proposed for the chemiluminometric determination of folic acid in pharmaceutical formulation. Water-soluble Mn-doped ZnS QDs were synthesized by using L-cysteine as stabilizer in aqueous solutions. The nanoparticles were structurally and optically characterized by X-ray powder diffraction (XRD), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), UV-Vis absorption spectroscopy and photoluminescence (PL) emission spectroscopy. The CL of ZnS QDs induced by directly chemical oxidation and its ionic liquid-sensitized effect in aqueous solution were then investigated. It was found that oxidants, especially hydrogen peroxide, could directly oxidize ZnS QDs to produce weak CL emission in basic conditions. In the presence of 1,3-dipropylimidazolium bromide/copper a drastic light emission enhancement is observed, related to a strong interaction between Cu(2+) and the imidazolium ring. Therefore, a new CL analysis system was developed for the determination of folic acid. Under the optimum conditions, there is a good linear relationship between the relative CL intensity and the concentration of folic acid in the range of 1×10(-9)-1×10(-)(6) M of folic acid with a correlation coefficient (R(2)) of 0.9991. The limit of detection of this system was found to be 1×10(-)(10) M. This method is not only simple, sensitive and low cost, but also reliable for practical applications.
authors: Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran. Electronic address: azizi@umz.ac.ir.
authors: Seyed Naser
authors: SN
authors: Azizi
authors: Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran.
authors: Parmis
authors: P
authors: Shakeri
authors: Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran.
authors: Mohammad Javad
authors: MJ
authors: Chaichi
authors: Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Ahmadreza
authors: A
authors: Bekhradnia
authors: Department of Chemistry, Polymer Chemistry Research Laboratory, University of Mazandaran, Babolsar 47416-95447, Iran.
authors: Mehdi
authors: M
authors: Taghavi
authors: Department of Chemistry, Polymer Chemistry Research Laboratory, University of Mazandaran, Babolsar 47416-95447, Iran.
authors: Mousa
authors: M
authors: Ghaemy
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D005492:Folic Acid / Q000032:analysis*; D052578:Ionic Liquids / Q000737:chemistry*; D057230:Limit of Detection; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods; D008345:Manganese / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D045663:Quantum Dots; D013440:Sulfides / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D052578:Ionic Liquids; D013440:Sulfides; D017967:Zinc Compounds; D008345:Manganese; D003300:Copper; D005492:Folic Acid; C031238:zinc sulfide
keywords: 1,3-Dipropylimidazolium bromide; Folic acid; Ionic liquid (IL); Sensitized chemiluminescence; ZnS quantum dot