title: High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.
abstract: [(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.
authors: Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA. pkeng@mednet.ucla.edu.
authors: Muhammad Rashed
authors: MR
authors: Javed
authors: Supin
authors: S
authors: Chen
authors: Jack
authors: J
authors: Lei
authors: Jeffrey
authors: J
authors: Collins
authors: Maxim
authors: M
authors: Sergeev
authors: Hee-Kwon
authors: HK
authors: Kim
authors: Chang-Jin
authors: CJ
authors: Kim
authors: R Michael
authors: RM
authors: van Dam
authors: Pei Yuin
authors: PY
authors: Keng
mesh_terms: D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D005462:Fluorine Radioisotopes; D044085:Microfluidics; D049268:Positron-Emission Tomography
chemical_list: D001549:Benzamides; D005462:Fluorine Radioisotopes; C574003:fallypride