title: Association of human leukocyte antigen class I polymorphism with spontaneous clearance of hepatitis B surface antigen in Qidong Han population.
abstract: OBJECTIVE
  To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population.
  
  
  METHODS
  We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years.
  
  
  RESULTS
  The frequency of HLA-A∗33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B∗13:01:01G was increased in HBsAg clearance group (P value is 0.0004).
  
  
  CONCLUSIONS
  These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.
authors: Medical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, China ; Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, China.
authors: Fengqin
authors: F
authors: Miao
authors: Hang
authors: H
authors: Sun
authors: Ning
authors: N
authors: Pan
authors: Jinhuan
authors: J
authors: Xu
authors: Jie
authors: J
authors: Qiu
authors: Yuqing
authors: Y
authors: Shen
authors: Wei
authors: W
authors: Xie
authors: Jianqiong
authors: J
authors: Zhang
mesh_terms: D000483:Alleles; D002681:China; D005500:Follow-Up Studies; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006514:Hepatitis B Surface Antigens; D015395:Histocompatibility Antigens Class I