title: No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population.
abstract: OBJECTIVE
  Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of epilepsies in adults. The calcium homeostasis modulator 1 gene (CALHM1) has been considered one of the candidate genes that play a role in epileptogenesis due to its function in calcium homeostasis and amyloid β (Aβ) regulation. Recently, the association of a single nucleotide polymorphism (rs11191692) of CALHM1 has been reported to be associated with MTLE in Han Chinese, but independent replication is needed. In the present study, rs11191692 and rs2986017 of CALHM1 were determined in 512 MTLE patients and 412 control subjects to investigate the possible involvement of CALHM1 in the etiology of MTLE.
  
  
  METHODS
  Genotyping was determined by polymerase chain reaction-restriction fragment length polymorphism method. Major statistical analyses were performed by SAS.
  
  
  RESULTS
  No significant differences in the genotypic or allelic frequencies of both single-nucleotide polymorphisms were revealed between subjects with and without MTLE (rs11191692: P=0.890 and 0.230; rs2986017: P=0.581 and 0.072). Further stratification analysis by gender and age, and analysis of clinical features in relation to MTLE also yielded negative results.
  
  
  CONCLUSIONS
  rs11191692 and rs2986017 of CALHM1 do not contribute substantially to MTLE in Han Chinese.
authors: The Department of Neurosurgery at the Affiliated Hospital of Xuzhou Medical College, 99 Huaihai West Road, Xuzhou, Jiangsu 221006, China.
authors: Xiang
authors: X
authors: Li
authors: The Department of Neurosurgery at the 463rd Hospital of Chinese PLA, 46 Xiaoheyan Road, Shenyang, Liaoning 110042, China.
authors: Yongcai
authors: Y
authors: Wang
authors: The Department of Neurosurgery at the Affiliated Hospital of Xuzhou Medical College, 99 Huaihai West Road, Xuzhou, Jiangsu 221006, China.
authors: Jia
authors: J
authors: Gu
authors: The Department of Neurosurgery at the Affiliated Hospital of Xuzhou Medical College, 99 Huaihai West Road, Xuzhou, Jiangsu 221006, China.
authors: Qingming
authors: Q
authors: Meng
authors: The Department of Neurosurgery at the Affiliated Hospital of Xuzhou Medical College, 99 Huaihai West Road, Xuzhou, Jiangsu 221006, China.
authors: Yong
authors: Y
authors: Gao
authors: The Department of Neurosurgery of Shengjing Hospital Affiliated to China Medical University, 36 No. 3 Street, Shenyang, Liaoning 100004, China. Electronic address: cmuhyzhao@gmail.com.
authors: Hongyu
authors: H
authors: Zhao
authors: The Department of Neurosurgery at the 463rd Hospital of Chinese PLA, 46 Xiaoheyan Road, Shenyang, Liaoning 110042, China. Electronic address: zhongminyin@yahoo.com.
authors: Zhongmin
authors: Z
authors: Yin
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D015220:Calcium Channels / Q000235:genetics*; D015331:Cohort Studies; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C530077:CALHM1 protein, human; D015220:Calcium Channels; D008562:Membrane Glycoproteins
keywords: Calcium homeostasis modulator 1; Mesial temporal lobe epilepsy; Single nucleotide polymorphism