title: A case of NUT midline carcinoma with no HPV infection, slight EWSR1 rearrangement and strong expression of EGFR.
abstract: NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV infection, EWSR1 rearrangement, and the status of the EGFR gene.
authors: Fausto
authors: F
authors: Maffini
authors: Christopher Alexander
authors: CA
authors: French
authors: Michael James
authors: MJ
authors: Cameron
authors: Viviana
authors: V
authors: Stufano
authors: Massimo
authors: M
authors: Barberis
authors: Eleonora
authors: E
authors: Pisa
authors: Michela
authors: M
authors: Manzotti
authors: Augusto
authors: A
authors: Cattaneo
authors: Elvio
authors: E
authors: De Fiori
authors: Giuseppe
authors: G
authors: Viale
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000556:secondary / Q000601:surgery*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D018773:Genes, erbB-1; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: C471990:BRD4-NUT fusion oncogene protein, human; D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins; C512478:EGFR protein, human; D066246:ErbB Receptors