title: A case of unusual mast cell response with interstitial cystitis-like symptoms to neoadjuvant chemotherapy for muscle-invasive transitional cell carcinoma of the bladder.
abstract: Randomized trials support the use of neoadjuvant chemotherapy in muscle-invasive bladder cancer based on a noted survival advantage, which appeared to be strongly related to downstaging of the cancer to pT0 (complete pathologic response). This report presents a case of an unusual mast cell response along with bladder wall thickening after neoadjuvant chemotherapy. However, the final cystectomy specimen did not reveal any residual tumor (pT0). The authors hypothesize that neoadjuvant chemotherapy could have caused the diffuse mast cell response, and that this profound inflammatory response can be used as a biomarker of complete response to chemotherapy.
authors: From the aDivision of Medical Oncology, bDepartment of Pathology, and cDivision of Urologic Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York.
authors: Venkata
authors: V
authors: Pokuri
authors: Norbert
authors: N
authors: Sule
authors: Yousef
authors: Y
authors: Soofi
authors: Bo
authors: B
authors: Xu
authors: Khurshid
authors: K
authors: Guru
authors: Saby
authors: S
authors: George
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000150:complications* / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D018856:Cystitis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D009336:Necrosis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000188:drug therapy