title: Comparative genomic analysis of eutherian ribonuclease A genes.
abstract: The present study attempted to update comprehensive eutherian ribonuclease A gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 448 ribonuclease A potential coding sequences, the present analysis annotated 255 complete coding sequences. The most comprehensive data set of eutherian ribonuclease A genes first characterized 13 major gene clusters, 9 of which showed evidence of differential gene expansions. In addition, the present analysis described common predicted promoter regions of eutherian ribonuclease A genes. The present study also attempted to resolve discrepancies in descriptions of eutherian ribonuclease A genes. Thus, the integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis proposed new classification and nomenclature of eutherian ribonuclease A genes, as new framework of future experiments.
authors: Laboratory of Genomics, Centre of Animal Reproduction, 55 Heinzel St., 10000, Zagreb, Croatia, Marko.Premzl@alumni.anu.edu.au.
authors: Marko
authors: M
authors: Premzl
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D016678:Genome; D023281:Genomics; D008322:Mammals / Q000235:genetics*; D058977:Molecular Sequence Annotation; D010802:Phylogeny; D012259:Ribonuclease, Pancreatic / Q000145:classification / Q000235:genetics*
chemical_list: D012259:Ribonuclease, Pancreatic