title: ChAMP: 450k Chip Analysis Methylation Pipeline.
abstract: The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-throughput DNA methylation analysis. Several methods for normalization and processing of these data have been published recently. Here we present an integrated analysis pipeline offering a choice of the most popular normalization methods while also introducing new methods for calling differentially methylated regions and detecting copy number aberrations.
  
  
  METHODS
  ChAMP is implemented as a Bioconductor package in R. The package and the vignette can be downloaded at bioconductor.org
authors: Medical Genomics, and Statistical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Shanghai 200031, China and Institute of Environmental Medicine, Karolinska Instytutet, 17177 Stockholm, Sweden.
authors: Tiffany J
authors: TJ
authors: Morris
authors: Lee M
authors: LM
authors: Butcher
authors: Andrew
authors: A
authors: Feber
authors: Andrew E
authors: AE
authors: Teschendorff
authors: Ankur R
authors: AR
authors: Chakravarthy
authors: Tomasz K
authors: TK
authors: Wojdacz
authors: Stephan
authors: S
authors: Beck
mesh_terms: D056915:DNA Copy Number Variations; D019175:DNA Methylation; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software