title: Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in slovenia.
abstract: Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus-Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus),M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava-Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.
authors: Miša
authors: M
authors: Korva
authors: Nataša
authors: N
authors: Knap
authors: Katarina Resman
authors: KR
authors: Rus
authors: Luka
authors: L
authors: Fajs
authors: Gašper
authors: G
authors: Grubelnik
authors: Matejka
authors: M
authors: Bremec
authors: Tea
authors: T
authors: Knapič
authors: Tomi
authors: T
authors: Trilar
authors: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, Ljubljana 1000, Slovenia. tatjana.avsic@mf.uni-lj.si.
authors: Tatjana Avšič
authors: TA
authors: Županc
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology*; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D058974:Phylogeography; D012367:RNA, Viral / Q000235:genetics; D012377:Rodentia; D017422:Sequence Analysis, DNA; D017524:Slovenia / Q000453:epidemiology
chemical_list: D012367:RNA, Viral