title: Antioxidant and SGC-7901 cell inhibition activities of Rhizoma Dioscoreae bulbiferae. ethanol extracts.
abstract: The objective of this research was to study the pharmacology of Dioscorea bulbifera L. on antioxidant and anticancer activity. Alcohol extracts of Dioscorea bulbifera L. were made out by different concentration alcohol; they were tested by Hydroxyl radical scavenging test, reducing capacity test and total antioxidant capacity test. In the anticancer test, MTT test was used to study the inhibition rate. The results told that 70% ethanol extracts could scavenge most DPPH· at 2 mg/ml. The rate was 55.2%; 80% ethanol extract could clear the most ·OH. The clearance rate was 51.2%. 80% ethanol crude extracts possessed the strongest reducing ability per gram of the extract equal to 49.3 µmol Fe(2 +). Different concentrations of the extracts could inhibit the proliferation of line SGC-7901, and with the concentration increased, the inhibition rate was gradually increased.
authors: Department of General Surgery, Qianfoshan Hospital, Shandong University.|Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Xiang
authors: X
authors: Chen
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Shu-Hui
authors: SH
authors: Wu
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Xiao-Bing
authors: XB
authors: Zeng
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Xu-Wei
authors: XW
authors: Jiang
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Xiao-Ping
authors: XP
authors: Chen
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Jie
authors: J
authors: Yuan
authors: Department of General Surgery, Shuguang Hospital Baoshan Branch, Shanghai University of Traditional Chinese Medicine, Shanghai 201900, P.R.China.
authors: Bao-Hua
authors: BH
authors: Lu
authors: Department of General Surgery, Qianfoshan Hospital, Shandong University.
authors: Jie
authors: J
authors: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000378:metabolism; D045744:Cell Line, Tumor; D027742:Dioscorea; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism; D010084:Oxidation-Reduction; D008517:Phytotherapy; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D027343:Rhizome; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Dioscorea bulbifera L.; SGC-7901; alcohol extracts; antioxidant