title: Redox-triggered self-rolling robust hydrogel tubes for cell encapsulation.
abstract: In this study, mechanically strong hydrogels are synthesized by photopolymerization of 2-vinyl-4,6-diamino-1,3,5-triazine, poly(ethylene glycol) methacrylate, and disulfide-containing cross-linker, N'N-bis(acryloyl)cystamine. The bilayer hydrogel with distinct cross-linking density is shown to self-roll into a 3D tube, which could still be well reinforced by hydrogen bondings, upon exposing reductants such as 1,4-dithio-DL-threitol (DTT) or L-glutathione (GSH), because the redox-induced cleavage of disulfide bonds results in the imbalanced internal shrinking stress between two layers. At an intracellular level of GSH, model L929 cells-seeded bilayer gel sheet could curl up into a 3D tubular scaffold where the cells maintained good viability.
authors: Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, P. R. China.
authors: Lu
authors: L
authors: Liu
authors: Ning
authors: N
authors: Wang
authors: Yanjiao
authors: Y
authors: Han
authors: Yongmao
authors: Y
authors: Li
authors: Wenguang
authors: W
authors: Liu
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002460:Cell Line; D002477:Cells / Q000737:chemistry* / Q000166:cytology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D051379:Mice; D010084:Oxidation-Reduction; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: cell encapsulation; hydrogel; redox; self-rolling