title: Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones.
abstract: Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis. A route to this class of compound has been developed. Key steps include Noyori reduction (which establishes the stereochemistry of the product), ring-closing metathesis, and simple functional group conversions to provide a set of substituted 4-HCPs in either enantiomeric form.
authors: Department of Medicinal Chemistry, University of Kansas , Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, Kansas 66047-3761, United States.
authors: Gurpreet
authors: G
authors: Singh
authors: Angelica
authors: A
authors: Meyer
authors: Jeffrey
authors: J
authors: Aubé
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; C070238:4-hydroxy-2-cyclopentenone