title: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: a randomized controlled trial.
abstract: OBJECTIVE
  To compare the effect of two lipid emulsions on the development of retinopathy of prematurity in very low birth weight infants.
  
  
  METHODS
  Randomized controlled study.
  
  
  METHODS
  Eighty very low birth weight infants receiving parenteral nutrition from the first day of life were evaluated. One of the two lipid emulsions were used in the study infants: Group 1 (n=40) received fish-oil based lipid emulsion (SmofLipid®) and Group 2 (n=40) soybean oil based lipid emulsion (Intralipid®).
  
  
  METHODS
  The development of retinopathy of prematurity and the need for laser photocoagulation were assessed.
  
  
  RESULTS
  The maternal and perinatal characteristics were similar in both groups. The median (range) duration of parenteral nutrition [14days (10-28) vs 14 (10-21)] and hospitalization [34days (20-64) vs 34 (21-53)] did not differ between the groups. Laboratory data including complete blood count, triglyceride level, liver and kidney function tests recorded before and after parenteral nutrition also did not differ between the two groups. In Group 1, two patients (5.0%) and in Group 2, 13 patients (32.5%) were diagnosed with retinopathy of prematurity (OR: 9.1, 95% CI 1.9-43.8, p=0.004). One patient in each group needed laser photocoagulation, without significant difference. Multivariate analysis showed that only receiving fish-oil emulsion in parenteral nutrition decreased the risk of development of retinopathy of prematurity [OR: 0.76, 95% CI (0.06-0.911), p=0.04].
  
  
  CONCLUSIONS
  Premature infants with very low birth weight receiving an intravenous fat emulsion containing fish oil developed less retinopathy of prematurity.
authors: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey. Electronic address: serbeken@yahoo.com.
authors: Serdar
authors: S
authors: Beken
authors: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors: Dilek
authors: D
authors: Dilli
authors: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors: Nurdan Dinlen
authors: ND
authors: Fettah
authors: Pediatric Ophthalmology Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors: Emrah Utku
authors: EU
authors: Kabataş
authors: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors: Ayşegül
authors: A
authors: Zenciroğlu
authors: Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors: Nurullah
authors: N
authors: Okumuş
mesh_terms: D000328:Adult; D004655:Emulsions; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D012178:Retinopathy of Prematurity / Q000188:drug therapy*; D016037:Single-Blind Method; D013024:Soybean Oil / Q000627:therapeutic use*
chemical_list: D004655:Emulsions; D005395:Fish Oils; D013024:Soybean Oil
keywords: Lipid emulsion; Parenteral nutrition; Retinopathy of prematurity