title: Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system.
abstract: The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation mechanisms exist. This review solely focuses on the genus Streptococcus and, in particular, on the so-called non-activating plasminogen binding proteins. Based on structural and functional differences, as well as on their mode of surface linkaging, three groups can be assigned: M-(like) proteins, surface displayed cytoplasmatic proteins with enzymatic activities ("moonlighting proteins") and other surface proteins. Here, the plasminogen binding sites and the interaction mechanisms are compared. Recent findings on the functional consequences of these interactions on tissue degradation and immune evasion are summarized.
authors: Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Hannover, Germany.
authors: Marcus
authors: M
authors: Fulde
authors: Michael
authors: M
authors: Steinert
authors: Simone
authors: S
authors: Bergmann
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D010958:Plasminogen / Q000378:metabolism*; D011485:Protein Binding; D013291:Streptococcus / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; C084529:plasminogen-binding protein, bacteria; D010958:Plasminogen; D005341:Fibrinolysin
keywords: M-protein; SCM; Streptococcus; enolase; phagocytosis; plasminogen; transmigration