title: Inotropic effect of dopamine on rat heart during postnatal ontogeny.
abstract: We studied the effect of dopamine in concentrations of 10(-9), 10(-8), 10(-7), 10(-6), and 10(-5) M on contraction strength of isolated myocardial strips from the right atrium and right ventricle of rats aging 21, 42, 56, and 100 days. Dopamine in a concentration of 10(-9) M had a positive inotropic effect in rats of various ages. Increasing the concentration of dopamine to 10(-7)-10(-5) M was accompanied by a negative inotropic effect on the heart.
authors: Department of Anatomy, Physiology, and Human Health Care, Kazan Federal University, Kazan, Russia. g.bilalova@mail.ru.
authors: G A
authors: GA
authors: Bilalova
authors: L M
authors: LM
authors: Kazanchikova
authors: T L
authors: TL
authors: Zefirov
authors: F G
authors: FG
authors: Sitdikov
mesh_terms: D000375:Aging; D000818:Animals; D016275:Atrial Function / Q000187:drug effects* / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D016276:Ventricular Function / Q000187:drug effects* / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; D018377:Neurotransmitter Agents; D004298:Dopamine