title: RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses.
abstract: The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8+T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON inhibitors may potentially prevent the outgrowth of micrometastases in cancer patients.
authors: Department of Oncological Sciences; Huntsman Cancer Institute; University of Utah; Salt Lake City, UT USA.
authors: Henok
authors: H
authors: Eyob
authors: Huseyin Atakan
authors: HA
authors: Ekiz
authors: Alana L
authors: AL
authors: Welm
keywords: CD8+ T-cell response; MSP; RON; TNF; antitumor immunity; immunotherapy; metastasis; tumor dormancy; tumor microenvironment