title: Clinical observation of 32P metabolic mode at the level of sub-target nuclides.
abstract: OBJECTIVE
  The aim of this paper was to observe the metabolic mode of 32P at the level of sub-target nuclides.
  
  
  METHODS
  Twenty-one cancer patients were locally injected with 32P-labelled glass microspheres and then observed to determine the equalization of 32P radionuclide metabolism in the tumor target. We imaged 3 sub-target regions of interest (ROI) 1/3 the size in both the anterior and posterior directions by bremsstrahlung single-photon emission computed tomography (SPECT) X-ray imaging. The radiation dose parameters of the beta rays including the initial dose rate, the effective half-life, and the effective half-life of the cumulative radiation dose were then calculated.
  
  
  RESULTS
  The radionuclide metabolism of the 21 complete tumor targets complied with the mono-compartmental model of index metabolism, but the level of tumor control did not correlate with radiation dose parameters. In contrast, the radionuclide metabolism of the 63 sub-targets did not comply with the mono-compartmental model. Instead, 32 sub-targets were better represented by bi-compartmental or tri-compartmental metabolic models. None of the remaining 31 sub-targets complied with index metabolism.
  
  
  CONCLUSIONS
  The complexity of the radiation dose at the sub-target level partially explains poor local tumor control. Future studies will be required to improve the expression of internal exposure to radiation dose parameters.
authors: Department of radiotherapy, Xuzhou tumor hospital (Affiliated with Jiangsu University), Xuzhou, China - zxgjh1992@qq.com.
authors: X
authors: X
authors: Zhang
authors: H
authors: H
authors: Xu
authors: T
authors: T
authors: Zhang
authors: M
authors: M
authors: Shen
authors: M
authors: M
authors: He
authors: C
authors: C
authors: Geng
authors: J
authors: J
authors: Wang
authors: Y
authors: Y
authors: Li
authors: L
authors: L
authors: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010761:Phosphorus Radioisotopes / Q000032:analysis*; D011829:Radiation Dosage; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
chemical_list: D010761:Phosphorus Radioisotopes