title: [Pregnancy and delivery in a patient with pure 46,XY karyotype. Summary of actual knowledge about XY women].
abstract: METHODS
  Summary review and a case report.
  
  
  METHODS
  GEST IVF, Centre of Reproductive Medicine, Prague.
  
  
  BACKGROUND
  In scientific literature there two syndrome have been described in the presence of pure 46,XY karyotype when an individual is phenotypically and psychosexually identified as a woman. Androgen insensitivity syndrome (AIS) and pure gonadal dysgenesis XY (GD XY, Swyer syndrome). Thanks to the presence of a uterus in Swyer syndrome we can treat this type of sterility with donated oocytes.
  
  
  METHODS
  The paper describes both syndromes from prenatal, genetical, endocrinological, oncological, reproductive and perinatological points of view. A case study concerning a patient with pure gonadal dysgenesis XY, who successfully became pregnant through a donated oocytes programme, is also described. The pregnancy progressed physiologically, and a healthy boy, 3820g/52cm, was delivered in term by ceasarean section.
  
  
  CONCLUSIONS
  In world scientific literature at least fifteen successful pregnancies with pure gonadal dysgenesis XY have been described. In spite of the expectation of diminished uterine capacity, children are born to term with a normal delivery weight.
  
  
  CONCLUSIONS
  This article should be considered as a summary of all actual knowledge about these patients. This article should be available and usefull for clinicians who come across XY females. The case study provides evidence that even an individual with male genetic gender can be pregnant and deliver a healthy child.
authors: M
authors: M
authors: Poláková
authors: D
authors: D
authors: Alexander
authors: J
authors: J
authors: Sulc
authors: L
authors: L
authors: Zetová
authors: R
authors: R
authors: Vlk
authors: A
authors: A
authors: Křepelová
authors: D
authors: D
authors: Zantová
mesh_terms: D036861:Delivery, Obstetric; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D059785:Karyotype; D008297:Male; D011247:Pregnancy