title: The future of targeted peptidomics.
abstract: Targeted MS is becoming increasingly important for sensitive and specific quantitative detection of proteins and respective PTMs. In this article, Ceglarek et al. [Proteomics Clin. Appl. 2013, 7, 794-801] present an LC-MS-based method for simultaneous quantitation of seven apolipoproteins in serum specimens. The assay fulfills many necessities of routine diagnostic applications, namely, low cost, high throughput, and good reproducibility. We anticipate that validation of new biomarkers will speed up with this technology and the palette of laboratory-based diagnostic tools will hopefully be augmented significantly in the near future.
authors: Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
authors: Peter
authors: P
authors: Findeisen
mesh_terms: D001053:Apolipoproteins / Q000032:analysis*; D001774:Blood Chemical Analysis / Q000379:methods*; D002853:Chromatography, Liquid; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D001053:Apolipoproteins; D010455:Peptides
keywords: MRM; MS; Protein quantitation; Targeted peptidomics