title: Efficacy of porcine placental extract on wrinkle widths below the eye in climacteric women.
abstract: OBJECTIVE
  Injections of human placental extract, which is known to play a role in skin regulation, have long been used for the treatment of skin wrinkles and non-healing wounds. Porcine placental extract (PPE), an oral supplement, was recently developed for this purpose. The aim of this study was to assess whether PPE has a positive effect on the improvement of fine wrinkles below the eye in climacteric women.
  
  
  METHODS
  We first non-invasively measured wrinkle widths with a skin analyzer in a cross-section of 185 healthy adult Japanese women. Next, 44 climacteric women with mild or few climacteric symptoms were enrolled into an open-label, randomized, controlled study of the effect of PPE on wrinkle widths. A retrospective comparison of wrinkle widths in 123 climacteric women with climacteric symptoms with or without PPE treatment was also performed.
  
  
  RESULTS
  Wrinkle widths below the eye in women ≥ 30 years of age were significantly higher than in women 20-29 years of age. Treatment with three capsules of PPE per day was significantly (p < 0.05) effective in reducing wrinkle widths at 24 weeks compared with control subjects. Retrospective analysis showed that subjects treated with three (p < 0.05) and six (p < 0.01) capsules of PPE per day observed a significant reduction in wrinkle widths compared with untreated subjects.
  
  
  CONCLUSIONS
  Oral PPE treatment is a possible option for improving the appearance of fine wrinkles below the eye in climacteric women.
authors: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa.
authors: C
authors: C
authors: Yoshikawa
authors: K
authors: K
authors: Koike
authors: F
authors: F
authors: Takano
authors: K
authors: K
authors: Sugiur
authors: N
authors: N
authors: Suzuki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D002214:Capsules; D000529:Complementary Therapies / Q000379:methods; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005143:Eyelids / Q000473:pathology*; D005260:Female; D006801:Humans; D007564:Japan; D008593:Menopause; D008875:Middle Aged; D010924:Placental Extracts / Q000008:administration & dosage / Q000009:adverse effects; D012189:Retrospective Studies; D015595:Skin Aging / Q000187:drug effects / Q000473:pathology; D013552:Swine; D016896:Treatment Outcome
chemical_list: D002214:Capsules; D010924:Placental Extracts
keywords: ALTERNATIVE MEDICINE; CLIMACTERIC SYMPTOMS; COMPLEMENTARY MEDICINE; PORCINE PLACENTAL EXTRACT; SKIN WRINKLING