title: MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.
abstract: Human herpesvirus-6 (HHV-6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV-6 viral particles and released into the extracellular environment. In addition, HHV-6A/B-infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV-6 infection, causing MHC class I molecules to be transported to virion assembly sites.
authors: Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
authors: Megumi
authors: M
authors: Ota
authors: Satoshi
authors: S
authors: Serada
authors: Tetsuji
authors: T
authors: Naka
authors: Yasuko
authors: Y
authors: Mori
mesh_terms: D002460:Cell Line; D015536:Down-Regulation; D055354:Exosomes / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport; D013347:Subcellular Fractions / Q000378:metabolism; D014771:Virion / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: MHC class I; human herpesvirus-6A/B; viral particles