title: Interval training does not modulate diastolic function in heart transplant recipients.
abstract: OBJECTIVE
  This study investigates the effect of aerobic interval training on diastolic function at rest and during exercise in stable heart transplant (HTx) recipients.
  
  
  METHODS
  Twenty-three stable HTx recipients (74% males, mean age 50 ± 14.9 years) were recruited to a training programme. Intervention was 8 weeks intensive training or control in a randomized controlled design.
  
  
  RESULTS
  At baseline, participants had normal or mild diastolic dysfunction at rest. During exercise, mean E/e' increased from 9.0 (± 2.8) to 12.8 (± 7.7) (p = 0.09), E/A increased from 2.1 (± 0.6) to 2.6 (± 0.7) (p = 0.02), and deceleration time decreased by over 50 ms, all markers of increased filling pressure. There were no correlations between diastolic function and VO 2 peak at baseline. After intervention VO 2 peak increased from 23.9 (± 4.5) to 28.3(± 6) ml/kg/min in the training group (difference between groups p = 0.0018). No consistent pattern of improvement in diastolic function at rest or during exercise was seen.
  
  
  CONCLUSIONS
  The study does not support a role of diastolic dysfunction in the limited exercise capacity of HTx recipients and suggests that in these patients peripheral factors are of greater importance.
authors: Department of Cardiology, Bispebjerg University Hospital , Copenhagen , Denmark.
authors: Tea
authors: T
authors: Monk-Hansen
authors: Christian H
authors: CH
authors: Dall
authors: Stefan B
authors: SB
authors: Christensen
authors: Martin
authors: M
authors: Snoer
authors: Finn
authors: F
authors: Gustafsson
authors: Hanne
authors: H
authors: Rasmusen
authors: Eva
authors: E
authors: Prescott
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole; D004452:Echocardiography; D017079:Exercise Tolerance; D005260:Female; D006339:Heart Rate; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D064797:Physical Conditioning, Human / Q000502:physiology*; D013599:Systole; D016277:Ventricular Function, Left; D055815:Young Adult