title: MATRICS cognitive consensus battery (MCCB) performance in children, adolescents, and young adults.
abstract: BACKGROUND
  Neurodevelopmental models of schizophrenia suggest that cognitive deficits may be observed during childhood and adolescence, long before the onset of psychotic symptoms. Elucidating the trajectory of normal cognitive development during childhood and adolescence may therefore provide a basis for identifying specific abnormalities related to the development of schizophrenia. The MATRICS Consensus Cognitive Battery (MCCB), which was designed for use in clinical trials targeting cognitive deficits most common in schizophrenia, may provide a mechanism to understand this trajectory. To date, however, there is no performance data for the MCCB in healthy children and adolescents. The present study sought to establish performance data for the MCCB in healthy children, adolescents, and young adults.
  
  
  METHODS
  The MCCB was administered to a community sample of 190 healthy subjects between the ages of 8 and 23years. All MCCB domain scores were converted to T-scores using sample means and standard deviations and were compared for significant performance differences between sex and age strata.
  
  
  RESULTS
  Analyses revealed age effects following quadratic trends in all MCCB domains, which is consistent with research showing a leveling off of childhood cognitive improvement upon approaching late adolescence. Sex effects after controlling for age only presented for one MCCB domain, with males exhibiting well-known spatial reasoning advantages.
  
  
  CONCLUSIONS
  Utilizing this performance data may aid future research seeking to elucidate specific deficits that may be predictive of later development of SZ.
authors: Division of Psychiatry Research, The Zucker Hillside Hospital, United States. Electronic address: gnitzburg@nshs.edu.
authors: George C
authors: GC
authors: Nitzburg
authors: Division of Psychiatry Research, The Zucker Hillside Hospital, United States.
authors: Pamela
authors: P
authors: Derosse
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, United States.
authors: Katherine E
authors: KE
authors: Burdick
authors: Division of Psychiatry Research, The Zucker Hillside Hospital, United States.
authors: Bart D
authors: BD
authors: Peters
authors: Division of Psychiatry Research, The Zucker Hillside Hospital, United States; Weill-Cornell Medical College, United States.
authors: Chaya B
authors: CB
authors: Gopin
authors: Division of Psychiatry Research, The Zucker Hillside Hospital, United States.
authors: Anil K
authors: AK
authors: Malhotra
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002657:Child Development; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D055815:Young Adult
keywords: Cognition; Neurodevelopment; Neuropsychology; Pediatric; Schizophrenia