title: Generative topographic mapping-based classification models and their applicability domain: application to the biopharmaceutics Drug Disposition Classification System (BDDCS).
abstract: Earlier (Kireeva et al. Mol. Inf. 2012, 31, 301-312), we demonstrated that generative topographic mapping (GTM) can be efficiently used both for data visualization and building of classification models in the initial D-dimensional space of molecular descriptors. Here, we describe the modeling in two-dimensional latent space for the four classes of the BioPharmaceutics Drug Disposition Classification System (BDDCS) involving VolSurf descriptors. Three new definitions of the applicability domain (AD) of models have been suggested: one class-independent AD which considers the GTM likelihood and two class-dependent ADs considering respectively, either the predominant class in a given node of the map or informational entropy. The class entropy AD was found to be the most efficient for the BDDCS modeling. The predominant class AD can be directly visualized on GTM maps, which helps the interpretation of the model.
authors: Faculté de Chimie, Université de Strasbourg, UMR 7140-Laboratoire de Chémoinformatique , 1 rue Blaise Pascal, 67000 Strasbourg, France.
authors: Héléna A
authors: HA
authors: Gaspar
authors: Gilles
authors: G
authors: Marcou
authors: Dragos
authors: D
authors: Horvath
authors: Alban
authors: A
authors: Arault
authors: Sylvain
authors: S
authors: Lozano
authors: Philippe
authors: P
authors: Vayer
authors: Alexandre
authors: A
authors: Varnek
mesh_terms: D000465:Algorithms; D001688:Biological Products / Q000737:chemistry / Q000145:classification*; D001702:Biopharmaceutics; D062313:Databases, Pharmaceutical; D015507:Drugs, Investigational / Q000737:chemistry / Q000145:classification*; D019277:Entropy; D006801:Humans; D015233:Models, Statistical; D055553:Prescription Drugs / Q000737:chemistry / Q000145:classification*; D012984:Software; D012995:Solubility
chemical_list: D001688:Biological Products; D015507:Drugs, Investigational; D055553:Prescription Drugs