title: Fluoropyrimidine toxicity in patients with dihydropyrimidine dehydrogenase (DPD) splice site variant: the need for further revision of dose and schedule.
authors: Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Paul Christiaan Dirk
authors: PC
authors: Bank
authors: Henk-Jan
authors: HJ
authors: Guchelaar
authors: Joachim Jesse
authors: JJ
authors: Swen
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003841:Deoxycytidine / Q000031:analogs & derivatives*; D054067:Dihydropyrimidine Dehydrogenase Deficiency / Q000235:genetics*; D005472:Fluorouracil / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D005472:Fluorouracil