title: Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: protective role of date palm fruit.
abstract: In this study, we investigated the antioxidant and protective properties of date fruit aqueous extract (DFAE) on trichloroacetic acid (TCA)-induced nephrotoxicity in rat. Oral administration of TCA as drinking water (0.5 and 2 g/L) daily for 2 months caused nephrotoxicity as evident by elevated levels of plasma creatinine, urea, and uric acid. Activity of antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx), was decreased, whereas superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were increased along with histopathological injuries. The oral administration of DFAE (4 mL/kg/day) to TCA-treated groups proved some significant correction by increasing the antioxidant activity of the CAT and GPx enzymes and normalizing the SOD activity and the MDA level (p < 0.05). It also protected kidney's histology and normalized the functions of this organ. It could be concluded that DFAE has a protective role against TCA-induced oxidative stress in rat, thereby protecting the renal tissue from TCA-induced damage.
authors: Research Unit "Genome, Immune Diagnosis and Recovery", Higher Institute of Biotechnology of Monastir, University of Monastir, Avenue Tahar Hadded, BP 74, 5000, Monastir, Tunisia, amira.arem@yahoo.fr.
authors: Amira
authors: A
authors: El Arem
authors: Mouna
authors: M
authors: Zekri
authors: Amira
authors: A
authors: Thouri
authors: Emna Behija
authors: EB
authors: Saafi
authors: Fatma
authors: F
authors: Ghrairi
authors: Amel
authors: A
authors: Ayed
authors: Abdelfattah
authors: A
authors: Zakhama
authors: Lotfi
authors: L
authors: Achour
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D018384:Oxidative Stress; D065749:Phoeniceae / Q000737:chemistry*; D051381:Rats; D014238:Trichloroacetic Acid / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014238:Trichloroacetic Acid