title: Proconvulsant action of two GABA(B) receptor antagonists is age-dependent.
abstract: Antagonists of GABA(B) receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABA(B) receptors at very early stages of maturation.
authors: Department of Developmental Epileptology, Institute of Physiology AS CR, Prague, Czech Republic. maresp@biomed.cas.cz.
authors: P
authors: P
authors: Mareš
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000367:Age Factors; D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D003292:Convulsants; D004195:Disease Models, Animal; D004357:Drug Synergism; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000503:physiopathology*; D058788:GABA-B Receptor Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D010721:Phosphinic Acids / Q000494:pharmacology*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000502:physiology
chemical_list: D003292:Convulsants; D058788:GABA-B Receptor Antagonists; D010721:Phosphinic Acids; D011412:Propanolamines; D018079:Receptors, GABA; C086109:3-aminopropyl-cyclohexylmethylphosphinic acid; C085075:CGP 55845A