title: E23K variant in KCNJ11 gene is associated with susceptibility to type 2 diabetes in the Mauritanian population.
abstract: OBJECTIVE
  Many genetic association studies reported the contribution of KCNJ11 gene to type 2 diabetes susceptibility in different populations. We aimed to evaluate the association between E23K variant of KCNJ11 and type 2 diabetes in the Mauritanian population.
  
  
  METHODS
  We performed a case-control association study including 135 type 2 diabetes Mauritanian patients and 135 controls. Genotyping for the E23K variant was performed using a TaqMan allelic discrimination assay.
  
  
  RESULTS
  We found significant association between KCNJ11 E23K variant and type 2 diabetes (Global model, OR=2.08, 95% CI=1.09-3.97, p=0.026). In the Moor ethnic group, E23K was also associated with type 2 diabetes in the general model (OR=2.08, 95% CI=1.09-3.97, p=0.026) and under the dominant model (OR=2.49, 95% CI=1.12-5.55, p=0.026). In the Mauritanians of African descent, KK genotype was not found. Besides, E23K variant was not associated with type 2 diabetes (OR=0.69, 95% CI=0.04-11.32, p=0.793).
  
  
  CONCLUSIONS
  Our results revealed the risk of type 2 diabetes conferred by KCNJ11 E23K gene variant in the Mauritanian population.
authors: Centre Hospitalier National, B.P. 4160, Nouakchott, Mauritania.
authors: Isselmou
authors: I
authors: Abdelhamid
authors: LR11IPT05, Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunisia.
authors: Khaled
authors: K
authors: Lasram
authors: Laboratoire de Biochimie et Biologie Moléculaire, Faculté des Sciences et Techniques, B.P. 5026, Nouakchott, Mauritania.
authors: Ghlana
authors: G
authors: Meiloud
authors: LR11IPT05, Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunisia.
authors: Nizar
authors: N
authors: Ben Halim
authors: LR11IPT05, Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunisia.
authors: Rym
authors: R
authors: Kefi
authors: Département de Chimie Biologique, UCAD, Dakar, Senegal.
authors: Abdoulaye
authors: A
authors: Samb
authors: LR11IPT05, Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunisia.
authors: Sonia
authors: S
authors: Abdelhak
authors: Laboratoire de Biochimie et Biologie Moléculaire, Faculté des Sciences et Techniques, B.P. 5026, Nouakchott, Mauritania. Electronic address: houmeida@hotmail.com.
authors: Ahmed
authors: A
authors: Houmeida
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D016015:Logistic Models; D008297:Male; D008435:Mauritania; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D012307:Risk Factors; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel
keywords: Diabetes; E23K; Mauritania