title: Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.
abstract: To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy.
authors: Department of Physics and Department of Mechanical & Materials Engineering, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA. jiaoj@pdx.edu.
authors: Lester
authors: L
authors: Lampert
authors: Brittany
authors: B
authors: Timonen
authors: Sean
authors: S
authors: Smith
authors: Brittney
authors: B
authors: Davidge
authors: Haiyan
authors: H
authors: Li
authors: John F
authors: JF
authors: Conley
authors: Jeffrey D
authors: JD
authors: Singer
authors: Jun
authors: J
authors: Jiao
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D016466:CHO Cells; D053148:Caspase 3 / Q000378:metabolism; D053179:Caspase 7 / Q000378:metabolism; D061945:Caspase Inhibitors / Q000494:pharmacology*; D003412:Cricetulus; D003713:Dendritic Cells / Q000187:drug effects*; D016503:Drug Delivery Systems; D046529:Microscopy, Electron, Transmission; D053770:Nanowires / Q000737:chemistry*; D011208:Powders / Q000737:chemistry
chemical_list: D061945:Caspase Inhibitors; D011208:Powders; D053148:Caspase 3; D053179:Caspase 7; D000537:Aluminum Oxide