title: Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study.
abstract: BACKGROUND
  Serum total and low-density lipoprotein (LDL) cholesterol levels are elevated in patients with nephrotic syndrome and those with kidney failure treated by peritoneal dialysis (PD), who are characterized by heavy losses of protein in urine and peritoneal dialysate, respectively. Hypercholesterolemia in nephrotic syndrome is associated with and largely due to acquired LDL receptor (LDLR) deficiency. Because PCSK9 (proprotein convertase subtilisin/kexin type 9) promotes degradation of LDLR, we tested the hypothesis that elevation of LDL cholesterol levels in patients with nephrotic syndrome and PD patients may be due to increased PCSK9 levels.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Patients with nephrotic syndrome or treated by PD or hemodialysis and age- and sex-matched healthy Korean individuals (n=15 in each group).
  
  
  METHODS
  Group and serum total and LDL cholesterol levels.
  
  
  RESULTS
  Plasma PCSK9 concentration.
  
  
  METHODS
  Concentrations of fasting serum PCSK9, lipids, and albumin, and urine protein excretion.
  
  
  RESULTS
  Mean serum total and LDL cholesterol levels in patients with nephrotic syndrome (317.9±104.2 [SD] and 205.9±91.1mg/dL) and PD patients (200.0±27.6 and 126.7±18.5mg/dL) were significantly (P<0.05) higher than in hemodialysis patients (140.9±22.9 and 79.1±19.5mg/dL) and the control group (166.5±26.5 and 95.9±25.2mg/dL). This was associated with significantly (P<0.05) higher plasma PCSK9 levels in patients with nephrotic syndrome (15.13±4.99ng/mL) and PD patients (13.30±1.40ng/mL) than in the control (9.19±0.60ng/mL) and hemodialysis (7.30±0.50ng/mL) groups. Plasma PCSK9 level was directly related to total and LDL cholesterol concentrations in the study population (r=0.559 [P<0.001] and r=0.497 [P<0.001], respectively).
  
  
  CONCLUSIONS
  Small number of participants may limit generalizability.
  
  
  CONCLUSIONS
  Nephrotic syndrome and PD are associated with higher plasma PCSK9 concentration, which can contribute to elevation of LDL levels by promoting LDLR deficiency.
authors: Department of Medicine, Inje University, Haeundae Paik Hospital, Busan, South Korea.
authors: Kyubok
authors: K
authors: Jin
authors: Department of Medicine, Inje University, Haeundae Paik Hospital, Busan, South Korea.
authors: Bong-Soo
authors: BS
authors: Park
authors: Department of Medicine, Inje University, Haeundae Paik Hospital, Busan, South Korea.
authors: Yang-Wook
authors: YW
authors: Kim
authors: Department of Medicine, Division of Nephrology and Hypertension, University of California Irvine, Irvine, CA. Electronic address: ndvaziri@uci.edu.
authors: Nosratola D
authors: ND
authors: Vaziri
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D010530:Peritoneal Dialysis; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases / Q000097:blood*; D006435:Renal Dialysis; D012697:Serine Endopeptidases / Q000097:blood*; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL; D002784:Cholesterol; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases
keywords: PCSK9 (proprotein convertase subtilisin/kexin type 9); Proteinuria; atherosclerosis; cardiovascular disease; hyperlipidemia; low-density lipoprotein (LDL) cholesterol; low-density lipoprotein (LDL) receptor