title: Interrupted time series design: a useful approach for studying interventions targeting participation.
abstract: Comparative effectiveness research (CER) strives for evidence to inform clinical decisions for specific clients in typical health care settings. While the randomized controlled trial (RCT) is well-aligned with the objectives of CER, this design may not be feasible or applicable to all research questions, particularly those pertaining to clinical decision making and individually based change. It is important, therefore, to consider alternative approaches, especially when studying complex and subjective outcomes such as children's participation. We propose the use of interrupted time series (ITS) quasi-experimental design for its potential application in determining the effectiveness of participation-focused interventions. In this perspective, ITS design is described, ascertaining its advantages and limitations, and suggestions are provided to overcome challenges to implementation. Results of a case study using the ITS approach to evaluate changes in participation of an adolescent with physical disabilities are described. Finally, strategies to implement this design in practice are suggested.
authors: 1School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada.
authors: Dana
authors: D
authors: Anaby
authors: Shalini
authors: S
authors: Lal
authors: Justine
authors: J
authors: Huszczynski
authors: Jana
authors: J
authors: Maich
authors: Jade
authors: J
authors: Rogers
authors: Mary
authors: M
authors: Law
mesh_terms: D002547:Cerebral Palsy / Q000534:rehabilitation; D057186:Comparative Effectiveness Research / Q000379:methods*; D003627:Data Interpretation, Statistical; D003657:Decision Making; D006801:Humans; D065186:Interrupted Time Series Analysis; D008297:Male; D009788:Occupational Therapy; D010347:Patient Care Planning; D057285:Precision Medicine; D058992:Social Participation; D055815:Young Adult
keywords: Evidence-based practice; interrupted time series; intervention; participation; research design