title: Context-dependent enhancer selection confers alternate modes of notch regulation on argos.
abstract: Wiring between signaling pathways differs according to context, as exemplified by interactions between Notch and epidermal growth factor receptor (EGFR) pathways, which are cooperative in some contexts but antagonistic in others. To investigate mechanisms that underlie different modes of cross talk, we have focused on argos, an EGFR pathway regulator in Drosophila melanogaster which is upregulated by Notch in adult muscle progenitors but is repressed in the wing. Results show that the alternate modes of cross talk depend on the engagement of enhancers with opposite regulatory logic, which are selected by context-determining factors. This is likely to be a general mechanism for enabling the wiring between these pathways to switch according to context.
authors: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
authors: Benjamin E
authors: BE
authors: Housden
authors: Ana
authors: A
authors: Terriente-Felix
authors: Sarah J
authors: SJ
authors: Bray
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D018010:Receptors, Invertebrate Peptide / Q000378:metabolism; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014921:Wings, Animal / Q000254:growth & development* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D005136:Eye Proteins; D009419:Nerve Tissue Proteins; D018010:Receptors, Invertebrate Peptide; D051880:Receptors, Notch; C075638:aos protein, Drosophila; C066532:Egfr protein, Drosophila; D066246:ErbB Receptors