title: [Role of GnRH agonists in preserving female fertility].
abstract: The impact of cancer treatment on ovarian function and fertility has been known since the 70s. Preservation of fertility is now an important focus of care for patients of reproductive age with cancer. The beneficial role of GnRH agonists in fertility preservation is controversial since the early 2000s. Recent randomized studies come to overturn this role. The POEMS multicenter randomized trial with long-term follow-up is ongoing and will provide results that could help clarify the current uncertain indication of these compounds in this context.
authors: Service de gynécologie obstétrique, médecine de la reproduction, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France. Electronic address: anne.thomin@tnn.aphp.fr.
authors: A
authors: A
authors: Thomin
authors: Service de gynécologie obstétrique, médecine de la reproduction, centre hospitalier intercommunal Poissy, 78300 Saint-Germain-en-Laye, France.
authors: A
authors: A
authors: Torre
authors: Service de gynécologie obstétrique, médecine de la reproduction, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
authors: É
authors: É
authors: Daraï
authors: Service de gynécologie obstétrique, médecine de la reproduction, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
authors: N
authors: N
authors: Chabbert-Buffet
mesh_terms: D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000009:adverse effects; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced; D016729:Leuprolide / Q000737:chemistry / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D010053:Ovary / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D017329:Triptorelin Pamoate / Q000737:chemistry / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide
keywords: Agonistes de la GnRH; Cancer; Chemotherapy; Chimiothérapie; Fertility preservation; GnRH agonists; Préservation de la fertilité