title: Rheumatic manifestations and an epipharyngeal mass accompanied by myelodysplastic syndrome.
abstract: We herein report two cases of myelodysplastic syndrome with rheumatic manifestations. (Case 1) A 70-year-old man presented with fever, arthritis and bone pain and developed cranial nerve palsy caused by an epipharyngeal mass. Steroid therapy led to a prolonged remission of the febrile condition and mass lesion. (Case 2) An 82-year-old male was treated for intractable polyarthritis and fever with steroid therapy, and serious side effects resulted in lethal pneumonia. We herein describe the entire course of steroid therapy in these two cases. Various rheumatic manifestations in myelodyaplastic syndrome often require empirical steroid therapy. It was effective for the soft tissue mass in Case 1, in which indolent lymphoma could not be denied, and was only partially effective for Case 2 of the febrile and putatively benign conditions, suggesting heterogeneous nature of rheumatic complications in myelodysplastic syndrome.
authors: Division of Rheumatic Diseases, National Center for Global Health and Medicine , Tokyo , Japan.
authors: Mariko
authors: M
authors: Inoue
authors: Toshikazu
authors: T
authors: Kano
authors: Takashi
authors: T
authors: Ozaki
authors: Yuko
authors: Y
authors: Takahashi
authors: Hiroyuki
authors: H
authors: Yamashita
authors: Hiroshi
authors: H
authors: Kaneko
authors: Akio
authors: A
authors: Mimori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000150:complications; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D017809:Fatal Outcome; D005334:Fever / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010243:Paralysis; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D049268:Positron-Emission Tomography; D013256:Steroids; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D013256:Steroids
keywords: Autoimmune manifestation; Glucocorticoid; Myelodysplastic syndrome