title: The influence of anhedonia on feedback negativity in major depressive disorder.
abstract: Anhedonia is associated with reward-processing deficits of the dopamine system, which may increase the risk of depression. Nevertheless, few previous studies have examined the influence of hedonic tone on event-related potential (ERP) measures of reward processing in major depressive disorder. A simple gambling task was used to elicit feedback negativity (FN), an ERP component elicited by feedback indicating gain versus loss, in 27 patients with major depression and 27 healthy participants. We found that participants with depression were characterized by reduced FN responses, especially towards monetary gains, but not losses, compared with healthy individuals. In addition, the amplitude of FN to gain feedback in participants with depression was related to anhedonia severity and depressive symptoms. These findings indicate an association between low hedonic capacity and reduction in FN. As a neural measure of reward sensitivity, FN may be generated in part by reward-related activity.
authors: Faculty of Health Management, Guangzhou Medical University, Guangzhou, China; Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Guangzhou Psychiatric Hospital, Guangzhou, China.
authors: Wen-hua
authors: WH
authors: Liu
authors: Guangzhou Psychiatric Hospital, Guangzhou, China.
authors: Ling-zhi
authors: LZ
authors: Wang
authors: Faculty of Health Management, Guangzhou Medical University, Guangzhou, China.
authors: He-rui
authors: HR
authors: Shang
authors: Faculty of Health Management, Guangzhou Medical University, Guangzhou, China.
authors: Yue
authors: Y
authors: Shen
authors: Faculty of Health Management, Guangzhou Medical University, Guangzhou, China.
authors: Zhi
authors: Z
authors: Li
authors: Castle Peak Hospital, Hong Kong Special Administrative Region, China.
authors: Eric F C
authors: EF
authors: Cheung
authors: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.
authors: Raymond C K
authors: RC
authors: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D059445:Anhedonia / Q000502:physiology*; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D005715:Gambling / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D025341:Principal Component Analysis; D012201:Reward; D013997:Time Factors; D055815:Young Adult
keywords: Anhedonia; Depression; Event-related potential; Feedback negativity; Reward