title: Central ventilatory and cardiovascular actions of serotonin in trout.
abstract: This study was undertaken to investigate the central actions of 5-HT on ventilatory and cardiovascular variables in the unanesthetized trout. Compared to vehicle, intracerebroventricular injection (ICV) of 5-HT elevated the total ventilation. This elevation was due to its stimulatory action on ventilatory amplitude. Moreover, 5-HT produced a dose-dependent increase in mean dorsal aortic blood pressure (PDA) without change in heart rate (fH). Methysergide, a 5-HT1/5-HT2 receptor antagonist, reduced the hyperventilatory and hypertensive actions of 5-HT. 8-OH-2-(di-n-propylamino) tetralin, a 5-HT1A receptor agonist, increased PDA while α-methyl-5-HT, a 5-HT2 receptor agonist, elevated all ventilatory variables and increased PDA without changing fH. Intra-arterial injection of 5-HT was without effect on ventilation, but 5-HT initially produced hypotension followed by hypertension. These changes were accompanied by tachycardia. It remains to be determined whether endogenous 5-HT within the brain of trout may act as a potent neuroregulator causing stimulatory effects on cardio-ventilatory functions. In the periphery, 5-HT may act as local modulator involved in vasoregulatory mechanisms.
authors: Université Européenne de Bretagne, Université de Brest, INSERM U650, Laboratoire de Traitement de l'Information Médicale, Laboratoire de Neurophysiologie, SFR 148 ScInBioS, Faculté de Médecine et des Sciences de la Santé, 22 avenue Camille Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
authors: Marc
authors: M
authors: Kermorgant
authors: Université Européenne de Bretagne, Université de Brest, INSERM U650, Laboratoire de Traitement de l'Information Médicale, Laboratoire de Neurophysiologie, SFR 148 ScInBioS, Faculté de Médecine et des Sciences de la Santé, 22 avenue Camille Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
authors: Frédéric
authors: F
authors: Lancien
authors: Université Européenne de Bretagne, Université de Brest, INSERM U650, Laboratoire de Traitement de l'Information Médicale, Laboratoire de Neurophysiologie, SFR 148 ScInBioS, Faculté de Médecine et des Sciences de la Santé, 22 avenue Camille Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
authors: Nagi
authors: N
authors: Mimassi
authors: Université Européenne de Bretagne, Université de Brest, INSERM U650, Laboratoire de Traitement de l'Information Médicale, Laboratoire de Neurophysiologie, SFR 148 ScInBioS, Faculté de Médecine et des Sciences de la Santé, 22 avenue Camille Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France. Electronic address: jean-claude.lemevel@univ-brest.fr.
authors: Jean-Claude
authors: JC
authors: Le Mével
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D007276:Injections, Intraventricular; D012119:Respiration / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D018490:Serotonin Agents / Q000494:pharmacology*; D014337:Trout
chemical_list: D018490:Serotonin Agents; D012701:Serotonin
keywords: 5-HT receptors; Central 5-HT; Hypertension; Hyperventilation; Intracerebroventricular injection; Teleost