title: Predictive factors for relapse in patients on buprenorphine maintenance.
abstract: OBJECTIVE
  Despite the dramatic increase in the use of buprenorphine for the treatment of opioid dependence, clinical outcomes of this treatment approach continue to need evaluation. This study examines factors associated with relapse and retention during buprenorphine treatment in a sample of opioid dependent outpatients.
  
  
  METHODS
  In a retrospective chart review of 62 patients with opioid dependence, relapse was determined by self-report, urine toxicology screens, and by checking the state controlled substance monitoring database. Data was analyzed using two-way tests of association and logistic regression.
  
  
  RESULTS
  Patients with comorbid anxiety disorders, active benzodiazepine use (contrary to clinic policy), or active alcohol abuse, were significantly more likely to relapse. Patients who relapsed were also more likely to be on a higher buprenorphine maintenance dose.
  
  
  CONCLUSIONS
  This study identifies relapse risk factors during buprenorphine treatment for opioid dependence. Future research is needed to determine whether modifying these factors may lead to improved treatment outcomes.
authors: Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Michael
authors: M
authors: Ferri
authors: Alistair J Reid
authors: AJ
authors: Finlayson
authors: Li
authors: L
authors: Wang
authors: Peter R
authors: PR
authors: Martin
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D060046:Maintenance Chemotherapy; D008297:Male; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000517:prevention & control*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009292:Narcotic Antagonists; D002047:Buprenorphine