title: Ethical issues in adolescent HIV research in resource-limited countries.
abstract: Globally, there are 5 million young people aged 15-24 years living with HIV, and many more millions are at risk for HIV acquisition. Compelling research questions exist that require the involvement of young people and other vulnerable populations in HIV-related research in diverse settings around the world. Despite this, there remains a reluctance to involve adolescent participants, including young women, in clinical research. Complex and, at times, contradictory legal and ethical requirements can be a challenge. Ethical benchmarks can be applied to ensure that research meets high-level standards and is planned for appropriately.
authors: *The Desmond Tutu HIV Centre, University of Cape Town, Cape Town; †HIV AIDS Vaccines Ethics Group, School of Applied Human Sciences, College of Humanities, UKZN, Pietermaritzburg, South Africa; ‡Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD; and §NIH Department of Bioethics, Clinical Center and Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD.
authors: Linda-Gail
authors: LG
authors: Bekker
authors: Catherine
authors: C
authors: Slack
authors: Sonia
authors: S
authors: Lee
authors: Seema
authors: S
authors: Shah
authors: Bill
authors: B
authors: Kapogiannis
mesh_terms: D000293:Adolescent; D035843:Biomedical Research / Q000941:ethics* / Q000592:standards; D003219:Confidentiality / Q000941:ethics; D003906:Developing Countries; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006295:Health Resources; D006801:Humans; D007258:Informed Consent / Q000941:ethics; D035842:Research Subjects; D035862:Vulnerable Populations