title: Mutagenicity of smoke condensates from Canadian cigarettes with different design features.
abstract: There is currently limited knowledge regarding the impact of different cigarette designs on the toxicological properties of cigarette smoke condensate (CSC). This study used the Salmonella Mutagenicity Assay to examine the mutagenic activity of mainstream CSCs from 11 commercial Canadian cigarette brands with different design features or tobacco blend. The brands were selected to include design features that are common for cigarettes sold in the Canadian market, as well as cigarettes with alternate filters (charcoal or MicroBlue™), the super slim design, and cigarettes containing mixed blends of different tobacco types. CSCs were obtained using the International Organization for Standardization (ISO) and Health Canada Intense (HCI) smoking regimes, and mutagenic activity was assessed using Salmonella strains TA98, YG1041 and YG5185. Comparisons of the commercial brands to the Kentucky 3R4F, the Canadian Monitor 8 reference and a Canadian best seller revealed no significant reduction in CSC mutagenicity for cigarettes with alternate filters. However, the super slim design did afford some reduction in mutagenic potency. Nevertheless, since the study did not attempt to evaluate the impact of the cigarette designs on human health at the individual or population level, the super slim cigarettes cannot be considered 'reduced-harm' cigarettes.
authors: Science Division, Office of Research and Surveillance, Controlled Substances and Tobacco Directorate, Health Canada, 150 Tunney's Pasture DRWY, Ottawa, Ontario K1A 0K9, Canada.
authors: Nemanja
authors: N
authors: Mladjenovic
authors: Rebecca M
authors: RM
authors: Maertens
authors: Paul A
authors: PA
authors: White
authors: Evelyn C
authors: EC
authors: Soo
mesh_terms: D002170:Canada; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D012907:Smoking / Q000009:adverse effects; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D014026:Nicotiana
chemical_list: D009153:Mutagens; D014028:Tobacco Smoke Pollution