title: Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes.
abstract: BACKGROUND
  The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM.
  
  
  RESULTS
  The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were used for data analysis. The frequency of acute histologic chorioamnionitis was 24% in patients with preterm PROM who delivered preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Newborns born to mothers with histologic chorioamnionitis had significantly higher rates of adverse neonatal outcome (74% vs 51%; p<0.005) than those without histologic chorioamnionitis. This relationship remained significant after adjustment for gestational age at preterm PROM, gestational age at delivery, and exposure to antenatal corticosteroids.
  
  
  CONCLUSIONS
  The presence of acute histologic chorioamnionitis is associated with adverse neonatal outcome in late preterm infants born to mothers with preterm PROM.
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea ; Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors: Seung Mi
authors: SM
authors: Lee
authors: Jeong Woo
authors: JW
authors: Park
authors: Byoung Jae
authors: BJ
authors: Kim
authors: Chan-Wook
authors: CW
authors: Park
authors: Joong Shin
authors: JS
authors: Park
authors: Jong Kwan
authors: JK
authors: Jun
authors: Bo Hyun
authors: BH
authors: Yoon
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002821:Chorioamnionitis / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000188:drug therapy / Q000473:pathology*; D011247:Pregnancy; D047928:Premature Birth / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones