title: Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review).
abstract: Wnt1 inducible signalling pathway protein-2 (WISP‑2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.
authors: Department of Gastro-enterological Cancers, Peking University Cancer Hospital, Beijing, P.R. China.
authors: Jiafu
authors: J
authors: Ji
authors: Cardiff University-Peking University Joint Cancer Institute, Beijing, P.R. China.
authors: Shuqin
authors: S
authors: Jia
authors: Cardiff University-Peking University Joint Cancer Institute, Beijing, P.R. China.
authors: Ke
authors: K
authors: Ji
authors: Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
authors: Wen G
authors: WG
authors: Jiang
mesh_terms: D055511:CCN Intercellular Signaling Proteins / Q000378:metabolism*; D063646:Carcinogenesis / Q000473:pathology*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D055511:CCN Intercellular Signaling Proteins; C413323:CCN5 protein, human; D012097:Repressor Proteins