title: Prognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome.
abstract: OBJECTIVE
  Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS).
  
  
  METHODS
  This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55%), history of syncope (n=17, 25%), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20%). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19%) and 44 patients (64%), respectively.
  
  
  RESULTS
  During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28%). Fourteen patients (20%) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95% confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events.
  
  
  CONCLUSIONS
  Appropriate shock (28%) and inappropriate shock (20%) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.
authors: Division of Cardiology, Department of Internal Medicine, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. yk.on@samsung.com.
authors: Myoung Kyun
authors: MK
authors: Son
authors: Kyeongmin
authors: K
authors: Byeon
authors: Seung-Jung
authors: SJ
authors: Park
authors: June Soo
authors: JS
authors: Kim
authors: Gi-Byoung
authors: GB
authors: Nam
authors: Kee-Joon
authors: KJ
authors: Choi
authors: You-Ho
authors: YH
authors: Kim
authors: Sang Weon
authors: SW
authors: Park
authors: Young-Hoon
authors: YH
authors: Kim
authors: Hyung Wook
authors: HW
authors: Park
authors: Jeong Gwan
authors: JG
authors: Cho
authors: Young Keun
authors: YK
authors: On
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000628:therapy*; D016757:Death, Sudden, Cardiac; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D056910:Republic of Korea; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Brugada syndrome; Korea; implantable cardioverter-defibrillator; sudden death; syncope