title: miR-92a/DUSP10/JNK signalling axis promotes human pancreatic cancer cells proliferation.
abstract: Pancreatic cancer is one of the most common types of cancers in the whole world with a poor prognosis. Finding out how the cancer form and develop is the most important way to cure this cancer. miRNAs, 21-22 nucleotides regulatory small non-coding RNAs, have been found to be critical involved in the growth of pancreatic cancer. In this study, we found that miR-92a was up regulated in three kinds of human pancreatic cancer cell lines. There is a correlation between miR-92a and malignant degree of human pancreatic cancer cell lines. Then we found that miR-92a was essential for promoting cell proliferation in human pancreatic cancer. Inhibition of the function of miR-92a repressed the proliferation of pancreatic cancer cells. Further, we found that miR-92a enhanced the activation of JNK signalling pathway by directly targeting the JNK signalling inhibitor DUSP10. DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation. Altogether, our study showed a miR-92a/DUSP10/JNK signalling pathway that plays an important role in regulating the proliferation of pancreatic cancer cells.
authors: Center of Transplant Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 421001, PR China; Department of General Surgery, the First Affiliated Hospital, South China University, Hengyang, 421001 Hunan, PR China.
authors: Gengsheng
authors: G
authors: He
authors: Department of Anesthesiology, The Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, PR China.
authors: Lei
authors: L
authors: Zhang
authors: Department of Anesthesiology, Jiangsu Provincial Hospital of Integrated Chinese Traditional and Western Medicine, 100, Shizi Street, Hongshan Road, 210028 Nanjing, PR China. Electronic address: lilicat2@163.com.
authors: Qing
authors: Q
authors: Li
authors: Department of Anesthesiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, 195 Tongbai Road, Zhengzhou City, 450007 Henan Province, PR China. Electronic address: yanglongqiu2@126.com.
authors: Longqiu
authors: L
authors: Yang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D054637:Dual-Specificity Phosphatases / Q000378:metabolism*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C541874:MIRN92 microRNA, human; D035683:MicroRNAs; D048031:JNK Mitogen-Activated Protein Kinases; C120407:DUSP10 protein, human; D054639:Mitogen-Activated Protein Kinase Phosphatases; D054637:Dual-Specificity Phosphatases
keywords: DUSP10; MiR-92a; Pancreatic cancer; Proliferation