title: Synthesis and biological activity of 3-[phenyl(1,3-thiazol-2-yl)-amino]propanoic acids and their derivatives.
abstract: New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.
authors: Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania. vytautas.mickevicius@ktu.lt.
authors: Vytautas
authors: V
authors: Mickevičius
authors: Aušra
authors: A
authors: Voskienė
authors: Ilona
authors: I
authors: Jonuškienė
authors: Ramūnė
authors: R
authors: Kolosej
authors: Jūratė
authors: J
authors: Šiugždaitė
authors: Petras Rimantas
authors: PR
authors: Venskutonis
authors: Rita
authors: R
authors: Kazernavičiūtė
authors: Zita
authors: Z
authors: Brazienė
authors: Elena
authors: E
authors: Jakienė
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D029741:Brassica rapa / Q000737:chemistry / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D005227:Fatty Acids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D011422:Propionates; C029658:propionic acid