title: Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4+and CD8+T cells.
abstract: CD4+T cells promote cytotoxic T lymphocyte (CTL)-mediated anticancer immune responses. We have recently identified ideal tumor-associated antigen (TAA)-derived long peptides (LPs) that elicit not only TAA-specific TH1 response, but also CTLs, through cross-presentation. The LP-specific TH1 cell responses were augmented in cancer patients vaccinated with CTL epitopes. Our findings support the clinical application of LP-based immunotherapy.
authors: Department of Immunogenetics, Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; Department of Respiratory Medicine; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan.
authors: Yusuke
authors: Y
authors: Tomita
authors: Yasuharu
authors: Y
authors: Nishimura
keywords: Type 1 helper T cell; cDNA microarray analysis; cross-presentation; helper T-cell epitope; peptide vaccine; tumor-associated antigen