title: Fundus autofluorescence imaging in multifocal choroiditis: beyond the spots.
abstract: OBJECTIVE
  To describe fundus autofluorescence (FAF) imaging and its correlation to spectral-domain optical coherence tomography (SD-OCT) in retinal areas that appear clinically noninvolved in patients with multifocal choroiditis/punctate inner choroidopathy (MFC/PIC).
  
  
  METHODS
  Six patients with MFC or PIC were evaluated during the disease course with multimodal imaging, which included fluorescein angiography, FAF imaging, indocyanine green angiography, and SD-OCT.
  
  
  RESULTS
  Five patients had acute and/or scarred chorioretinal spots at presentation. Five patients had choroidal neovascularization. FAF imaging in all patients disclosed diffuse peripapillary and/or posterior-pole hyperautofluorescent plaques in areas that appeared clinically to be noninvolved. Corresponding SD-OCT scans revealed severe disruption of the inner segment/outer segment junction. Findings resolved with corticosteroid treatment Conclusions: FAF imaging of patients with MFC/PIC reveals extensive pathology beyond the clinically apparent spots. FAF findings highlight the areas of corresponding anatomic disruption of the photoreceptor-retinal pigment epithelium complex.
authors: Department of Ophthalmology, Rabin Medical Center , Petach Tikva , Israel .
authors: Michal
authors: M
authors: Kramer
authors: Ethan
authors: E
authors: Priel
mesh_terms: D000328:Adult; D002833:Choroiditis / Q000175:diagnosis* / Q000188:drug therapy; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D000080364:Multifocal Choroiditis; D011379:Prognosis; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D005938:Glucocorticoids; D007208:Indocyanine Green
keywords: Fundus autofluorescence (FAF); multifocal choroiditis (MFC); punctate inner choroidopathy (PIC); spectral-domain-OCT (SD-OCT)