title: Peanut sensitization profiles in Italian children and adolescents with specific IgE to peanuts.
abstract: Peanuts are one of the most relevant foods implicated in IgE-mediated adverse reactions in pediatric population. This study aimed to evaluate the pattern of sensitization towards five peanut allergenic components (rAra h 1, 2, 3, 8 and 9) in a population of Italian children and adolescents with specific IgE (sIgE) to peanut. rAra h 9 was the main allergen implicated in peanut sensitization (58%), followed by rAra h 8 (35%), rAra h 2 (27%), rAra h 3 (23%) and rAra h 1 (12.5%). rAra h 1, 2, and 3 were the main allergenic components in young children: 8/13 (62%) between 2 and 5 years, 8/23 (35%) between 6 and 11 years, and 3/12 (25%) between 1 and 16 years. No differences were found among the levels of sIgE towards rAra h 1, 2, 3, and 9 in the three groups; in contrast, the levels of sIgE against rAra h 8 showed an increasing trend according to age. In conclusion rAra h 1, 2, and 3 were the prevalent sensitizing allergens during the first years of life in Italian patients with sIgE to peanuts ("genuine" allergy); in contrast rAra h 9 and 8 were mainly involved in school-age children and adolescents with pollen allergy ("secondary" sensitization).
authors: UO Pediatria, Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
authors: Elisabetta
authors: E
authors: Calamelli
authors: Carlo
authors: C
authors: Caffarelli
authors: Giampaolo
authors: G
authors: Ricci
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000097:blood / Q000276:immunology*; D010367:Arachis / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male
chemical_list: D000485:Allergens; D007073:Immunoglobulin E