title: Synthesis of nitrogen-containing furanose sugar nucleotides for use as enzymatic probes.
abstract: The sugar nucleotides UDP-2-acetamido-2-deoxy-α-D-galactofuranose (UDP-GalfNAc) and UDP-2-azido-2-deoxy-α-D-galactofuranose (UDP-GalfN3) have been synthesized in preparative scale for the first time. These compounds are useful probes for studying the biosynthesis of glycans containing galactofuranose and/or 2-acetamido-2-deoxy-α-D-galactofuranose residues.
authors: Alberta Glycomics Centre and Department of Chemistry, Gunning-Lemieux Chemistry Centre, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.
authors: Ryan B
authors: RB
authors: Snitynsky
authors: Todd L
authors: TL
authors: Lowary
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D004926:Escherichia coli / Q000201:enzymology; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D016695:Glycosyltransferases / Q000737:chemistry / Q000378:metabolism*; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000201:enzymology; D009584:Nitrogen / Q000737:chemistry* / Q000378:metabolism; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011134:Polysaccharides / Q000096:biosynthesis / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D005663:Furans; D015335:Molecular Probes; D009705:Nucleosides; D011134:Polysaccharides; D016695:Glycosyltransferases; D009584:Nitrogen