title: Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests.
abstract: BACKGROUND
  High-resolution computed tomography (HRCT) plays an important role in the diagnosis and staging of pulmonary sarcoidosis, but implies radiation exposure. In this light, we aimed to describe HRCT findings as well as their relationship with pulmonary function tests (PFT) in children with pulmonary sarcoidosis.
  
  
  METHODS
  In a retrospective study, 18 pediatric patients with sarcoidosis, including 12 with pulmonary abnormalities (PA group) and 6 without pulmonary abnormalities (APA group) were followed over a 16-year period. Relationships between HRCT scores and PFT were studied by non-parametric Spearman's test at diagnosis and by restricted maximum likelihood (REML) analysis during follow-up.
  
  
  RESULTS
  Forty-three HRCT were scored. Twelve patients showed abnormal HRCT findings at diagnosis with multiple nodules or micronodules, while ground-glass opacities were seen in 11 patients. Ten patients exhibited pleural thickening or thickening of the fissure and 6 had interlobular septal thickening at diagnosis. No correlation between HRCT and forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), forced expiratory flow during the mid-half of the FVC (FEF(25-75)) and specific dynamical compliance (SpecC(Ldyn)) was found at diagnosis. However, linear mixed models showed that changes in total HRCT scores over time were significantly associated with SpecC(Ldyn), FVC, and FEV1 modifications.
  
  
  CONCLUSIONS
  Radiologic findings in children with pulmonary sarcoidosis were similar to those in adults. HRCT and PFT are both essential investigations at diagnosis; however, the correlation between HRCT pulmonary parenchymal findings and PFT over time suggests the possibility of reducing the number of HRCT during follow-up to decrease unnecessary radiation exposure.
authors: Université Pierre et Marie Curie, Paris, France; AP-HP, Hôpital Armand Trousseau, Service de Radiologie Pédiatrique, Paris, France.
authors: C
authors: C
authors: Sileo
authors: R
authors: R
authors: Epaud
authors: M
authors: M
authors: Mahloul
authors: N
authors: N
authors: Beydon
authors: D
authors: D
authors: Elia
authors: A
authors: A
authors: Clement
authors: H Ducou
authors: HD
authors: Le Pointe
mesh_terms: D000293:Adolescent; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002648:Child; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008137:Longitudinal Studies; D008168:Lung / Q000000981:diagnostic imaging*; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D007703:Peptidyl-Dipeptidase A
keywords: childhood; computed tomography; imaging; lung function