title: Trace elements, oxidative stress and glycemic control in young people with type 1 diabetes mellitus.
abstract: Trace elements and oxidative stress are associated with glycemic control and diabetic complications in type 1 diabetes mellitus. In this study, we analyzed the levels of serum copper, zinc, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) and urinary MDA and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in 33 type 1 diabetic patients with optimal and suboptimal glycemic control (HbA1C<9.0%) and 40 patients with poor glycemic control (HbA1C≥9%) and 27 age- and sex-matched non-diabetic controls to evaluate the differences between these markers in different glycemic control states. Diabetic patients, especially poor-glycemic-control subjects (HbA1C≥9%), exhibited significantly lower levels of serum zinc and increased levels of serum copper (and, therefore, increased serum copper-to-zinc ratios), serum SOD, blood MDA, and urinary MDA and 8-OHdG, relative to non-diabetic subjects. Furthermore, significant correlations existed in these patients between the serum copper, serum copper-to-zinc ratio, and urinary MDA (all p<0.001) and the levels of urinary 8-OHdG (p=0.007) and HbA1C. Our results suggest that high serum copper levels and oxidative stress correlate with glycemic control. Therefore, strict glycemic control, decreased oxidative stress, and a lower copper concentration might prevent diabetic complications in patients with type 1 diabetes mellitus.
authors: Community Healthcare Center, Fooyin University Hospital, Pingtung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Fooyin University, Kaohsiung, Taiwan.
authors: Ching-Chiang
authors: CC
authors: Lin
authors: Department of Laboratory Medicine, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung, Taiwan.
authors: Hsiu-Hua
authors: HH
authors: Huang
authors: Department of Public Health, Chung Shan Medical University, Taichung, Taiwan.
authors: Chiung-Wen
authors: CW
authors: Hu
authors: School and College of Medicine, Kaohsiung Medical University, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Bai-Hsiun
authors: BH
authors: Chen
authors: Division of Chest Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Inn-Wen
authors: IW
authors: Chong
authors: Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Yu-Ying
authors: YY
authors: Chao
authors: Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: yelihu@kmu.edu.tw.
authors: Yeou-Lih
authors: YL
authors: Huang
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003300:Copper / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000652:urine; D018384:Oxidative Stress / Q000502:physiology*; D014131:Trace Elements / Q000378:metabolism*; D055815:Young Adult; D015032:Zinc / Q000097:blood
chemical_list: D001786:Blood Glucose; D014131:Trace Elements; D008315:Malondialdehyde; D003300:Copper; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D015032:Zinc
keywords: 8-Hydroxy-2′-deoxyguanosine; Copper; Malondialdehyde; Type 1 diabetes mellitus; Zinc