title: Postprandial changes of lipoprotein profile: effect of abdominal obesity.
abstract: BACKGROUND
  Majority of studies that focused on the influence of abdominal obesity on lipoprotein profile, were conducted in the fasting conditions. The effects of visceral fat accumulation on postprandial lipoprotein concentrations have not yet been studied in details. We therefore focused on the postprandial lipoprotein profile in otherwise healthy men and women with abdominal obesity and their comparison with the control group of volunteers with normal waist circumference. The concentration of lipoprotein classes and subclasses was measured before and 4 hours after a standard meal by linear polyacrylamide gel electrophoresis.
  
  
  RESULTS
  A statistically significant postprandial rise in triacylglycerol concentration occurred in all subjects. VLDL increased 4 hours after meal in all subjects except the women with normal waist circumference. The concentration of large IDL particles increased in both non-obese men and women. In women with abdominal obesity, however, it decreased, while in obese men there was no statistically significant change. The concentration of small and medium-sized IDL particles decreased in all volunteers. Analyzing subclasses changes of large, medium-sized and small LDL particles we saw no significant shift in their concentrations except the subclass of large LDL particles, which decreased in men. Concentrations of medium and small HDL particles decreased postprandially in all volunteers with normal waist circumference. However, they remained unchanged in subjects with abdominal obesity.
  
  
  CONCLUSIONS
  We observed significant postprandial changes of the lipoprotein profile, but the nature and extent of these changes depended on gender and presence of abdominal obesity.
authors: Peter
authors: P
authors: Sabaka
authors: Department of Cardiovascular Diseases, International Clinical Research Center, St, Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic. peter.kruzliak@savba.sk.
authors: Peter
authors: P
authors: Kruzliak
authors: Ludovit
authors: L
authors: Gaspar
authors: Martin
authors: M
authors: Caprnda
authors: Matej
authors: M
authors: Bendzala
authors: David
authors: D
authors: Balaz
authors: Stanislav
authors: S
authors: Oravec
authors: Andrej
authors: A
authors: Dukat
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D056128:Obesity, Abdominal / Q000097:blood*; D010316:Particle Size; D019518:Postprandial Period; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D014280:Triglycerides