title: Molecular characteristics of MDR Mycobacterium tuberculosis strains isolated in Fujian, China.
abstract: Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two "false-negative" results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Qiuyang
authors: Q
authors: Chen
authors: National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Yu
authors: Y
authors: Pang
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Qingfu
authors: Q
authors: Liang
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Shufang
authors: S
authors: Lin
authors: National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Yufeng
authors: Y
authors: Wang
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Jian
authors: J
authors: Lin
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Yong
authors: Y
authors: Zhao
authors: Fujian Center for Disease Control and Prevention, Fujian, China.
authors: Shuzhen
authors: S
authors: Wei
authors: Fujian Center for Disease Control and Prevention, Fujian, China. Electronic address: Zhjf_8888@126.com.
authors: Jinfeng
authors: J
authors: Zheng
authors: Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China; Beijing Chest Hospital, Capital Medical University, Beijing, China. Electronic address: suhuazheng342@sohu.com.
authors: Suhua
authors: S
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000187:drug effects / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D002374:Catalase / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005188:False Negative Reactions; D005260:Female; D017353:Gene Deletion; D006801:Humans; D006867:Hydrolases / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D018088:Tuberculosis, Multidrug-Resistant / Q000178:diet therapy / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; D006867:Hydrolases; C527647:HsaD protein, Mycobacterium tuberculosis
keywords: MDR; Molecular characteristics; Mycobacterium tuberculosis