title: Comparison of lovastatin and hyaluronic acid/carboxymethyl cellulose on experimental created peritoneal adhesion model in rats.
abstract: OBJECTIVE
  The aim of this experimental study was to compare the effectiveness and reliability of lovastatin and hyaluronic acid + carboxymethyl cellulose (Seprafilm).
  
  
  METHODS
  Thirty two female Wistar-Albino rats weighing between 250 and 300 g were used in the study. The rats were divided into four groups as sham, control, lovastatin and Seprafilm each of which contained 8 rats. All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, microscopic adhesion and tPA, MDA and NO values were evaluated.
  
  
  RESULTS
  Macroscopic adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05). Microscopic classification adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05), and the tPA, MDA and NO values showed statistically significant differences among the groups.
  
  
  CONCLUSIONS
  Lovastatin and Seprafilm were equally effective in preventing postoperative intra abdominal adhesions. The study groups were showed significant superiority to the control group.
authors: Bozok University, Faculty of Medicine, Department of Surgery, Yozgat, Turkey. Electronic address: ergnrsln@hotmail.com.
authors: Ergin
authors: E
authors: Arslan
authors: Kayseri Training and Education Hospital, Department of Surgery, Kayseri, Turkey.
authors: Tutkun
authors: T
authors: Talih
authors: Erciyes University, Faculty of Medicine, Department of Surgery, Kayseri, Turkey.
authors: Bahadir
authors: B
authors: Oz
authors: Aksaray State Hospital, Department of Surgery, Aksaray, Turkey.
authors: Bülent
authors: B
authors: Halaclar
authors: Bozok University, Faculty of Medicine, Department of Surgery, Yozgat, Turkey.
authors: Kasim
authors: K
authors: Caglayan
authors: Bozok University, Faculty of Medicine, Department of Surgery, Yozgat, Turkey.
authors: Mesut
authors: M
authors: Sipahi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008148:Lovastatin / Q000494:pharmacology*; D010532:Peritoneal Diseases / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control
chemical_list: C118198:Seprafilm; D006820:Hyaluronic Acid; D008148:Lovastatin
keywords: Adhesion severity; Lovastatin; Peritoneal adhesion; Seprafilm