title: Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics.
abstract: Copper catalyzed coupling of Mannich reagents to aza-propargylglycine residues has been employed to synthesize constrained aza-lysine peptides. Employing growth hormone releasing peptide-6 (GHRP-6) as a model peptide and a variety of secondary amines, 18 aza-Lys analogs were synthesized by this so-called A(3)-coupling reaction. This effective method for making constrained aza-Lys-peptides offers strong potential for exploring various recognition events implicating lysine residues including post-translational peptide modification.
authors: Département de Chimie, Université de Montréal , C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.
authors: Jinqiang
authors: J
authors: Zhang
authors: Caroline
authors: C
authors: Proulx
authors: Anna
authors: A
authors: Tomberg
authors: William D
authors: WD
authors: Lubell
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D010455:Peptides; D008239:Lysine