title: Primary intraosseous schwannoma in tibial epiphysis with unique immunohistochemical phenotype: a case report.
abstract: Schwannoma is a benign peripheral nerve sheath neoplasm of soft tissue that consistently demonstrates immunohistochemical staining for S100 protein. Intraosseous location of schwannoma is very uncommon. We report the first case of an intraosseous schwannoma located in the epiphysis of tibia in an adult patient. Radiologically, it mimicked a primary bone tumor and despite benign histological appearance, the tumor eroded cortical bone. Morphologically on routine stains and electron microscopy it has features of a schwannoma. But by immunohistochemistry, the tumor was positive for both desmin and S100 protein in the same region.
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA.
authors: Tao
authors: T
authors: Wang
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA.
authors: Juan M
authors: JM
authors: Giugale
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA.
authors: Ming
authors: M
authors: Ding
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA.
authors: Mark A
authors: MA
authors: Goodman
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA.
authors: Karen
authors: K
authors: Schoedel
authors: University of Pittsburgh Medical Center, Presbyterian Shadyside Hospitals, Pittsburgh PA, USA raounm@upmc.edu.
authors: Uma N M
authors: UN
authors: Rao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000473:pathology*; D004838:Epiphyses / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009442:Neurilemmoma / Q000473:pathology*; D010641:Phenotype; D013977:Tibia / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: primary intraosseous schwannoma; tibial epiphysis