title: PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation.
abstract: Malaria is a global public health challenge, with drug resistance a major barrier to disease control and elimination. To meet the urgent need for better treatments and vaccines, a deeper knowledge of Plasmodium biology and malaria epidemiology is required. An improved understanding of the genomic variation of malaria parasites, especially the most virulent Plasmodium falciparum (Pf) species, has the potential to yield new insights in these areas. High-throughput sequencing and genotyping is generating large amounts of genomic data across multiple parasite populations. The resulting ability to identify informative variants, particularly single-nucleotide polymorphisms (SNPs), will lead to the discovery of intra- and inter-population differences and thus enable the development of genetic barcodes for diagnostic assays and clinical studies. Knowledge of genetic variability underlying drug resistance and other differential phenotypes will also facilitate the identification of novel mutations and contribute to surveillance and stratified medicine applications. The PlasmoView interactive web-browsing tool enables the research community to visualise genomic variation and annotation (eg, biological function) in a geographic setting. The first release contains over 600,000 high-quality SNPs in 631 Pf isolates from laboratory strains and four malaria-endemic regions (West Africa, East Africa, Southeast Asia and Oceania).
authors: Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.
authors: Mark D
authors: MD
authors: Preston
authors: Samuel A
authors: SA
authors: Assefa
authors: Harold
authors: H
authors: Ocholla
authors: Colin J
authors: CJ
authors: Sutherland
authors: Steffen
authors: S
authors: Borrmann
authors: Alexis
authors: A
authors: Nzila
authors: Pascal
authors: P
authors: Michon
authors: Tran Tinh
authors: TT
authors: Hien
authors: Teun
authors: T
authors: Bousema
authors: Christopher J
authors: CJ
authors: Drakeley
authors: Issaka
authors: I
authors: Zongo
authors: Jean-Bosco
authors: JB
authors: Ouédraogo
authors: Abdoulaye A
authors: AA
authors: Djimde
authors: Ogobara K
authors: OK
authors: Doumbo
authors: Francois
authors: F
authors: Nosten
authors: Rick M
authors: RM
authors: Fairhurst
authors: David J
authors: DJ
authors: Conway
authors: Cally
authors: C
authors: Roper
authors: Taane G
authors: TG
authors: Clark
mesh_terms: D000818:Animals; D001483:Base Sequence; D016054:DNA, Protozoan / Q000235:genetics; D018503:Genome, Protozoan / Q000235:genetics*; D006801:Humans; D020407:Internet; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology*; D058977:Molecular Sequence Annotation; D010963:Plasmodium falciparum / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D016054:DNA, Protozoan
keywords: Plasmodium falciparum; drug resistance; genomics; malaria; vaccine targets; visualization