title: Effects of astaxanthin-enriched yeast on mucosal IgA induction in the jejunum and ileum of weanling mice.
abstract: The present study was conducted to clarify the effects of astaxanthin-enriched yeast on the concentration of immunoglobulin A (IgA), the numbers of IgA antibody-secreting cells (ASC) and the messenger RNA (mRNA) expression of IgA C-region in the jejunum and ileum of weanling mice. Weanling mice were fed rodent feed or astaxanthin-enriched yeast-supplemented rodent feed for 7, 14 or 21 days. Supplemental astaxanthin-enriched yeast increased the numbers of IgA ASC in the jejunum and ileum after 7, 14 and 21 days of treatment. Supplemental astaxanthin-enriched yeast increased IgA concentrations in the jejunum after 21 days of treatment, but IgA concentrations in the ileum were not affected by the treatment. The mRNA expressions of IgA C-region in the jejunum after 14 and 21 days of treatment and the ileum after 14 days of treatment were enhanced by supplementation of astaxanthin-enriched yeast. These results indicate that supplementation of astaxanthin-enriched yeast is effective to enhance the numbers of IgA ASC in the jejunum and ileum and IgA concentrations in the ileum of weanling mice.
authors: Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors: Tatsuhiko
authors: T
authors: Nagayama
authors: Miki
authors: M
authors: Sugimoto
authors: Shuntaro
authors: S
authors: Ikeda
authors: Shinichi
authors: S
authors: Kume
mesh_terms: D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements; D015870:Gene Expression / Q000187:drug effects; D007082:Ileum / Q000276:immunology* / Q000378:metabolism*; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000235:genetics; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D007583:Jejunum / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000378:metabolism; D014886:Weaning; D024341:Xanthophylls / Q000008:administration & dosage / Q000494:pharmacology; D015003:Yeasts
chemical_list: D007070:Immunoglobulin A; D012333:RNA, Messenger; D024341:Xanthophylls; C005948:astaxanthine
keywords: IgA; astaxanthin; ileum; jejunum; weanling mice