title: Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy.
abstract: BACKGROUND
  Thrombotic microangiopathy (TMA) is caused by various conditions, such as decreased a ADAMTS13 level, activated or injured vascular endothelial cells or activated platelets. This study examined the soluble platelet glycoprotein VI (sGPVI) levels in patients with TMA to evaluate the activation of platelets in thrombotic states.
  
  
  METHODS
  The plasma levels of sGPVI, ADAMTS13 activity, von Willebrand factor (VWF) and VWF propeptide (VWFpp) were measured in patients with TMA.
  
  
  RESULTS
  The plasma levels of sGPVI were significantly higher in postoperative patients, patients with TMA and those with disseminated intravascular coagulation (DIC) than in those without thrombosis. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 and those were significantly reduced after plasma exchange.
  
  
  CONCLUSIONS
  The measurement of sGPVI level is therefore considered to be important for the diagnosis and evaluation of TMA.
authors: Departments of Hematology and Oncology, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Yoshiki
authors: Y
authors: Yamashita
authors: Biology Laboratory, Discovery Research, Mochida Pharmaceutical CO., LTD. Shizuoka, Japan.
authors: Katsuki
authors: K
authors: Naitoh
authors: Molecular and Laboratory Medicine, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan. Electronic address: wadahide@clin.medic.mie-u.ac.jp.
authors: Hideo
authors: H
authors: Wada
authors: Molecular and Laboratory Medicine, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Makoto
authors: M
authors: Ikejiri
authors: Blood transfusion, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Takeshi
authors: T
authors: Mastumoto
authors: Blood transfusion, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Koshi
authors: K
authors: Ohishi
authors: Biology Laboratory, Discovery Research, Mochida Pharmaceutical CO., LTD. Shizuoka, Japan.
authors: Yoshitaka
authors: Y
authors: Hosaka
authors: Clinical Research Support Center, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Masakatsu
authors: M
authors: Nishikawa
authors: Departments of Hematology and Oncology, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
authors: Naoyuki
authors: N
authors: Katayama
mesh_terms: D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D015153:Blotting, Western; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D047468:Immunoprecipitation; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D057049:Thrombotic Microangiopathies / Q000097:blood*; D055815:Young Adult; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI; D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
keywords: ADAMTS13; Platelet activation; TMA; sGPVI