title: Heterotrimetallic Ru(II)/Pd(II)/Ru(II) complexes: synthesis, crystalstructure, spectral characterization, DFT calculation and antimicrobial study.
abstract: New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)2(η(3)-triamine)]Cl (5) (triemine=N(1)-(2-aminoethyl)-1,2-ethanediamine) have been synthesized by reacting [RuCl2(PPh3)3] (1) with one mole equivalent of N(1)-(2-aminoethyl)-1,2-ethanediamine in dichloromethane. Reaction of (2) with half-equivalent of (PhCN)2PdCl2 or Pd(OAc)2 in dichloromethane as a solvent afforded two novel heterotrimetallic Ru(II)-Pd(II)-Ru(II) complexes, [Ru(II)Cl2(PPh3)2(triamine)]2[Pd(II)X2](X=Cl, OAc) (3 and 4), bearing bioactive ligand. The progress of the undertaken reactions was monitored by (31)P{1H} NMR and FTIR. Crystal structure of complex 2 was confirmed by X-ray diffraction. The absorption spectrum of 2 in dichloromethane was modeled by time-dependent density functional theory (TD-DFT). The in vitro antimicrobial studies of complex 2-5 against an array of microorganisms (bacteria and fungi) were conducted. Complexes 3 and 4 exhibit high dual antibacterial and antifungal activity inhibiting microorganisms possibly via hydrolytic pathway which further evidenced by electrochemical analyses. The complexes 3 and 4 show a high inhibitory activity at 200 μg/ml concentration, suggesting that complexes 3 and 4 are two efficient catalytic inhibitor of microorganisms and further, they should be tested against cancer strains.
authors: Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan. Electronic address: manoaimi@hu.edu.jo.
authors: Mousa
authors: M
authors: Al-Noaimi
authors: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors: Ayman
authors: A
authors: Nafady
authors: Department of Chemistry, AN-Najah National University, Nablus, Occupied Palestinian Territory. Electronic address: warad@najah.edu.
authors: Ismail
authors: I
authors: Warad
authors: Department of Chemistry, College of Science, Taiz University, P.O. Box 6803, Republic of Yemen.
authors: Rwaida
authors: R
authors: Alshwafy
authors: Department of Chemistry, AN-Najah National University, Nablus, Occupied Palestinian Territory.
authors: Ahmad
authors: A
authors: Husein
authors: Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan.
authors: Wamidh H
authors: WH
authors: Talib
authors: Laboratoire LCM, Faculty of Sciences, University Mohammed 1[er], Oujda 60000, Morocco.
authors: Taibi Ben
authors: TB
authors: Hadda
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D010165:Palladium / Q000494:pharmacology; D066244:Proton Magnetic Resonance Spectroscopy; D011789:Quantum Theory; D012428:Ruthenium / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D010165:Palladium; D012428:Ruthenium
keywords: Antimicrobial activity; DFT calculation; Electrochemistry; Ruthenium(II)/palladium(II) complexes; Triamine; X-ray diffraction