title: Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.
abstract: We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a surgical lung biopsy and by excluding other causes of granulomatous disease. In paucisymptomatic/asymptomatic patients, as in our case, therapy is not necessary, with a good prognosis and complete recovery. NSG is a rare systemic disease similar to sarcoidosis and Wegener's granulomatosis with a benign clinical course and should always be considered for patients with nodular pulmonary lesions even with subclinical or uncommon features.
authors: Department of Radiology, Venetian Oncology Institute, Padua, Italy.
authors: Chiara
authors: C
authors: Giraudo
authors: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
authors: Nazarena
authors: N
authors: Nannini
authors: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
authors: Elisabetta
authors: E
authors: Balestro
authors: Department of Medicine, Hospital of Montebelluna, Treviso, Italy.
authors: Alessia
authors: A
authors: Meneghin
authors: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
authors: Francesca
authors: F
authors: Lunardi
authors: Department of Radiology, Venetian Oncology Institute, Padua, Italy.
authors: Roberta
authors: R
authors: Polverosi
authors: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy. fiorella.calabrese@unipd.it.
authors: Fiorella
authors: F
authors: Calabrese
mesh_terms: D001416:Back Pain / Q000209:etiology; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D033162:Incidental Findings; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012075:Remission, Spontaneous
keywords: Wegener's granulomatosis; back pain; granulomatous disease; histopathology; pulmonary nodules; sarcoidosis