title: Management of erythropoiesis: cross-sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people.
abstract: Although erythroid abnormalities (anemia and polycythemia) are commonly observed pathological conditions, not much information about borderline abnormalities is available. In this study, a cross-sectional study to analyze the relationships between erythropoiesis and nutrition, physical features, and laboratory test findings was conducted in middle-aged and older men and women. The study included 3519 Japanese people (1579 men and 1940 women), age 40 years and over. Analysis of variance showed that the group with a tendency to anemia was older, had a lower body mass index and diastolic blood pressure, and had higher serum adiponectin and creatinine. Multiple regression analysis showed that adiponectin, triglycerides, and total protein were common factors that affected erythropoiesis in both men and women. Hepatic, renal, and cardiac functions were also factors involved in erythropoiesis in men and in postmenopausal women. In addition, nutrient factors such as alcohol, vitamins, and carbohydrates were also significantly involved in erythropoiesis in men, but there were no significant nutrient factors involved in erythropoiesis in either premenopausal or postmenopausal women. This study showed that factors that influence erythropoiesis differ between men, premenopausal women, and postmenopausal women, and it suggested that appropriately modifying erythropoiesis management for each group of people is essential.
authors: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata, Japan.
authors: Kei
authors: K
authors: Kohno
authors: Hiroto
authors: H
authors: Narimatsu
authors: Yosuke
authors: Y
authors: Shiono
authors: Ikuko
authors: I
authors: Suzuki
authors: Yuichi
authors: Y
authors: Kato
authors: Akira
authors: A
authors: Fukao
authors: Isao
authors: I
authors: Kubota
authors: Yoshiyuki
authors: Y
authors: Ueno
authors: Takamasa
authors: T
authors: Kayama
authors: Takeo
authors: T
authors: Kato
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism*; D000368:Aged; D000740:Anemia / Q000097:blood / Q000378:metabolism; D044466:Asian People; D003430:Cross-Sectional Studies; D004906:Erythrocyte Count; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008593:Menopause; D008875:Middle Aged; D009752:Nutritional Status; D011086:Polycythemia / Q000097:blood / Q000378:metabolism; D012307:Risk Factors
chemical_list: D052242:Adiponectin
keywords: adiponectin; cross-sectional study; erythropoiesis; nutrition