title: Cancer-associated fibroblasts and macrophages: Friendly conspirators for malignancy.
abstract: Inflammation, which is now recognized as an hallmark of cancer, is intimately linked to the reactivity of stromal fibroblasts. Accumulating evidence indicate that cancer-associated fibroblasts not only drive the epithelial-mesenchymal transition and metabolically sustain the growth of cancer cells, but also engage in a reciprocal relationship with M2 macrophages that dramatically boost malignancy.
authors: Department of Experimental and Clinical Biomedical Sciences; Tuscany Tumor Institute; University of Florence; Florence, Italy ; "Center for Research, Transfer and High Education DenoTHE"; Florence, Italy.
authors: Paola
authors: P
authors: Chiarugi
keywords: M2-macrophages; cancer associated fibroblasts; endothelial precursor cells; epithelila-mesenchymal transition; stemness; tumor microenvironment