title: High-frequency percussive ventilation improves oxygenation and ventilation in pediatric patients with acute respiratory failure.
abstract: OBJECTIVE
  High-frequency percussive ventilation (HFPV) in pediatrics has been described predominantly in burned patients. We aimed to describe its effectiveness and safety in noninhalational pediatric acute respiratory failure (ARF).
  
  
  METHODS
  We conducted an observational study in a tertiary care pediatric intensive care unit on 31 patients with ARF failing conventional ventilation transitioned to HFPV. Demographics, ventilator settings, oxygenation index, oxygen saturation index, oxygen saturation as measured by pulse oximetry/fraction of inspired oxygen (Fio2), and Pao2/Fio2 were recorded before and during HFPV.
  
  
  RESULTS
  Initiation of HFPV was associated with improvements in oxygenation index, oxygen saturation index, Pao2/Fio2, and oxygen saturation as measured by pulse oximetry/Fio2 as early as 12 hours (P < .05), which continued through 48 hours after transition. Improved oxygenation occurred without an increase in mean airway pressures. Reductions in Paco2 occurred 6 hours after initiation of HFPV and continued through 48 hours (P < .01). Improved gas exchange was accompanied by reduced peak-inflating pressures at all time intervals after initiation of HPFV (P < .01). Vasopressor scores were similar before and after initiation of HFPV in patients requiring vasoactive support. Twenty-six (83.9%) of 31 patients survived to hospital discharge.
  
  
  CONCLUSIONS
  In a heterogeneous population of pediatric ARF failing conventional ventilation, HFPV efficiently improves gas exchange in a lung-protective manner.
authors: Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors: Nicole A
authors: NA
authors: Rizkalla
authors: Department of Respiratory Care, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors: Cheryl L
authors: CL
authors: Dominick
authors: Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors: Julie C
authors: JC
authors: Fitzgerald
authors: Department of Pediatrics and Public Health Science, Division of Pediatric Critical Care Medicine, Penn State Hershey Children's Hospital, Hershey, PA.
authors: Neal J
authors: NJ
authors: Thomas
authors: Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address: yehyan@email.chop.edu.
authors: Nadir
authors: N
authors: Yehya
mesh_terms: D000208:Acute Disease; D002056:Burns / Q000150:complications; D002648:Child; D002675:Child, Preschool; D005260:Female; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000378:metabolism / Q000628:therapy*; D056152:Respiratory Rate
chemical_list: D010100:Oxygen
keywords: Acute lung injury; Acute respiratory distress syndrome; Acute respiratory failure; High-frequency percussive ventilation; High-frequency ventilation