title: Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization.
abstract: The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.
authors: Institute of Chemistry & BioMedical Sciences (ICBMS), Nanjing University, Nanjing 210093, P. R. China.
authors: Jianbin
authors: J
authors: Wu
authors: Guanghui
authors: G
authors: An
authors: Siqi
authors: S
authors: Lin
authors: Jianbo
authors: J
authors: Xie
authors: Wei
authors: W
authors: Zhou
authors: Hao
authors: H
authors: Sun
authors: Yi
authors: Y
authors: Pan
authors: Guigen
authors: G
authors: Li
mesh_terms: D002845:Chromatography; D003460:Crystallization; D004745:Enkephalins / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D004745:Enkephalins; D010455:Peptides; C053673:biphalin