title: [A case report of recurrent small bowel adenocarcinoma successfully treated with monoclonal antibody against EGFR and S-1].
abstract: A man in 30s was admitted to our hospital with a complaint of abdominal and back pain. Abdominal CT scan showed a large mass and double balloon endoscopy detected a tumor of the jejunum. The pathological diagnosis of biopsy samples was poorly differentiated adenocarcinoma. After radical resection, adjuvant chemotherapy with mFOLFOX6 was administered, however, a recurrent lesion developed. Although the lesion was successfully removed again, it did not react to the combination therapy with irinotecan and cisplatin. Because the tumor showed a high percentage of epidermal growth factor receptor (EGFR) expression and also had a wild-type KRAS status, a therapeutic strategy targeting EGFR was selected. The patient started on panitumumab associated with S-1 and obtained a complete response on CT 6 weeks later. Small bowel adenocarcinoma is an aggressive malignancy with a poor prognosis and little information about its definitive chemotherapy. Analysis of molecular characterization, an increase in reported experience, and prospective trials are needed to improve a prognosis.
authors: Dept. of Surgery, Tottori Red Cross Hospital.
authors: Yumi
authors: Y
authors: Yamaguchi
authors: Hideaki
authors: H
authors: Nishidoi
authors: Shunsuke
authors: S
authors: Shibata
authors: Yoshimi
authors: Y
authors: Ozaki
authors: Tsuyoshi
authors: T
authors: Ueta
authors: Yutaka
authors: Y
authors: Yamashiro
authors: Minoru
authors: M
authors: Ishiguro
authors: Hirofumi
authors: H
authors: Kudo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007580:Jejunal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D000077544:Panitumumab; D012008:Recurrence; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077544:Panitumumab