title: Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting.
abstract: A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
authors: Department of Preventive Cardiology, Mid America Heart Institute at Saint Luke's Hospital, University of Missouri-Kansas City, Kansas City, Missouri. Electronic address: jjdinicol@gmail.com.
authors: James J
authors: JJ
authors: DiNicolantonio
authors: Department of Pharmacy, Centennial Medical Center, Nashville, Tennessee.
authors: Craig J
authors: CJ
authors: Beavers
authors: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, Louisiana.
authors: Arthur R
authors: AR
authors: Menezes
authors: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, Louisiana; Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors: Carl J
authors: CJ
authors: Lavie
authors: Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri.
authors: James H
authors: JH
authors: O'Keefe
authors: The Heart Hospital, University College London Hospitals UCLH, London, United Kingdom.
authors: Pascal
authors: P
authors: Meier
authors: Department of Interventional Cardiology, Heart Centre, University of Pécs, Hungary.
authors: András
authors: A
authors: Vorobcsuk
authors: Department of Interventional Cardiology, Heart Centre, University of Pécs, Hungary; Department of Cardiology, Heart Center, Balatonfüred, Hungary.
authors: Dániel
authors: D
authors: Aradi
authors: Department of Interventional Cardiology, Heart Centre, University of Pécs, Hungary.
authors: András
authors: A
authors: Komócsi
authors: Cardiovascular Diseases, St. Luke's - Roosevelt Hospital Center, Division of Cardiology, New York, New York.
authors: Saurav
authors: S
authors: Chatterjee
authors: Division of Cardiology, Department of Internal Medicine, Città Della Salute e della Scienza, San Giovanni battista, Turin, Italy.
authors: Fabrizio
authors: F
authors: D'Ascenzo
authors: Department of Mathematical Sciences, Politecnico di Torino.
authors: Mauro
authors: M
authors: Gasparini
authors: Department of Cardiology, Erasmus MC Thoraxcenter, Rotterdam, The Netherlands.
authors: Jasper
authors: J
authors: Brugts
authors: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
authors: Giuseppe
authors: G
authors: Biondi-Zoccai
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000209:etiology / Q000517:prevention & control*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000601:surgery*; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use*; D011184:Postoperative Period; D011412:Propanolamines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000889:Anti-Arrhythmia Agents; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D008790:Metoprolol