title: A study on the inhibitory effect of Solanum lyratum Thunb extract on Lewis lung carcinoma lines.
abstract: The objective of this paper was to observe the effects of Solanum lyratum Thunb extract on tumour inhibition, immune function and survival time of tumour-bearing mice. Lung carcinoma-bearing mouse model was established, the tumour-bearing mice were divided into model group, CTX group, Solanum lyratum Thunb extract high-dose group and low-dose group. By the examination of tumour inhibition rate of Solanum lyratum Thunb extract in Lewis lung carcinoma-bearing mice and determination of the number of NK cells and T cell subsets, the survival rate of tumour-bearing mice was observed. Solanum lyratum Thunb extract had some anti-tumour effect in Lewis tumour-bearing mice. The tumour inhibition rate of high-dose group reached 46.28%, and the tumour inhibition rate of low-dose group was 31.42%. Solanum lyratum Thunb extract can improve the NK cell activity of Lewis tumour-bearing mice, increase the number of CD4 cells in the tumour-bearing mice, and significantly increase the survival rate of tumour-bearing mice. The study concluded that Solanum lyratum Thunb extract has some anti-tumour effect and can improve immune function and survival rate of tumour-bearing mice.
authors: Department of Gastroenterology, the Third Hospital of Xiangya, Central South University, Changsha 410013, Hunan Province, China.
authors: Zhi-Ming
authors: ZM
authors: Xiao
authors: Ai-Min
authors: AM
authors: Wang
authors: Xiao-Yan
authors: XY
authors: Wang
authors: Shou-Rong
authors: SR
authors: Shen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D018827:Carcinoma, Lewis Lung; D049109:Cell Proliferation / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008175:Lung Neoplasms; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D032322:Solanum; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Solanum lyratum Thunb; anti-tumour effect; tumour-bearing mice