title: Bone chips, fibrin glue, and osteogeneration following lateral suboccipital craniectomy: a case report.
abstract: BACKGROUND
  Suboccipital craniectomy is a conventional approach for exploring cerebellopontine angle lesions. A variety of techniques have been successfully employed to reconstruct a craniectomy. This is the first report about the histological findings after performing a cranioplasty by using a mixture of autologous bone chips and human allogenic fibrin glue.
  
  
  METHODS
  A 53-year-old German woman underwent left lateral suboccipital retrosigmoidal craniectomy for treatment of trigeminal neuralgia in 2008. Cranioplasty was perfomed by using a mixture of autologous bone chips and human allogenic fibrin glue. Due to recurrent neuralgia, a second left lateral suboccipital craniectomy was performed in 2012. The intraoperative findings revealed a complete ossification of the former craniotomy including widely mature trabecular bone tissue in the histological examination.
  
  
  CONCLUSIONS
  A mixture of autologous bone chips and human allogenic fibrin glue seems to provide sufficient bone-regeneration revealed by histological and neuroradiological examinations.
authors: Departments of Neurosurgery, University of Würzburg, Josef-Schneider-Str, 11, Würzburg D-97080, Germany. t.linsenmann@gmx.de.
authors: Thomas
authors: T
authors: Linsenmann
authors: Camelia M
authors: CM
authors: Monoranu
authors: Almuth F
authors: AF
authors: Kessler
authors: Ralf I
authors: RI
authors: Ernestus
authors: Thomas
authors: T
authors: Westermaier
mesh_terms: D001861:Bone Regeneration / Q000187:drug effects*; D003399:Craniotomy; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D009777:Occipital Bone / Q000000981:diagnostic imaging / Q000601:surgery*; D011859:Radiography; D019651:Plastic Surgery Procedures / Q000379:methods*; D014277:Trigeminal Neuralgia / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D015718:Fibrin Tissue Adhesive