title: Prophylaxis of neutropenic fever with ciprofloxacin in patients with acute myeloid leukemia treated with intensive chemotherapy.
abstract: OBJECTIVE
  Neutropenic fever is one of the most serious complications after induction chemotherapy in acute myeloid leukemia (AML). Prophylaxis with antibiotics for prevention of neutropenic fever in AML is controversial and there are few studies on this issue from developing countries.
  
  
  METHODS
  In this retrospective study, we analyzed the clinical data and outcome of patients with AML who did or did not receive prophylactic ciprofloxacin 500 mg BD for neutropenic fever.
  
  
  RESULTS
  A total of 69 AML patients were treated by "3 + 7" protocol for their first induction chemotherapy. Prophylaxis was given to 25 of them. Incidence of neutropenic fever was the same in both groups (80% vs 82%). Duration of fever and the mortality rate were also similar in both groups.
  
  
  CONCLUSIONS
  It seems that in developing countries, using prophylactic ciprofloxacin has no significant effect on the incidence of neutropenic fever and the outcome of the AML patients.
authors: Department of Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mojtaba
authors: M
authors: Ghadiany
authors: Department of Oncology, Hamedan University of Medical Sciences, Hamedan, Iran.
authors: Hossein
authors: H
authors: Rahimi
authors: Department of Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Hamid
authors: H
authors: Rezvani
authors: Department of Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Afshin
authors: A
authors: Mohammad Alizadeh
authors: Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Nasim
authors: N
authors: Zamani
authors: Department of Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mahshid
authors: M
authors: Mehdizadeh
authors: Department of Oncology, Yazd University of Medical Sciences, Yazd, Iran.
authors: Mohammad
authors: M
authors: Foratyazdi
mesh_terms: D000293:Adolescent; D000368:Aged; D019072:Antibiotic Prophylaxis / Q000379:methods*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies
chemical_list: D002939:Ciprofloxacin
keywords: ciprofloxacin; fluoroquinolone; leukemia; neutropenic fever; prophylaxis