title: Cerebral hemodynamic changes and pain perception during venipuncture: is glucose really effective?
abstract: Newborns are exposed to a considerable number of painful stimuli. This study is aimed to investigate the effects of 30% glucose solution and nonnutritive sucking on pain perception during venipuncture. Twenty-five term infants were randomized as receiving 30% dextrose (group 1) or sterile water (group 2). Neonatal Infant Pain Scale scores, skin conductance algesimeter recordings, and near-infrared spectroscopy measurements were recorded during the procedure. Neonatal Infant Pain Scale and skin conductance algesimeter results were decreased in both groups from that during venipuncture to after the procedure. Group 1 had lower Neonatal Infant Pain Scale scores compared with group 2 after venipuncture, different from the skin conductance algesimeter, where no difference was observed between groups. In group 1, cerebral blood volume increased after venipuncture. Glucose does not attenuate the Neonatal Infant Pain Scale score and skin conductance algesimeter index during venipuncture, but it leads to a lower Neonatal Infant Pain Scale score after venipuncture unlike the skin conductance algesimeter index, which was not lowered.
authors: 1Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Gazi University, Ankara, Turkey.
authors: Serdar
authors: S
authors: Beken
authors: Ibrahim Murat
authors: IM
authors: Hirfanoğlu
authors: Kıvılcım
authors: K
authors: Gücüyener
authors: Ebru
authors: E
authors: Ergenekon
authors: Ozden
authors: O
authors: Turan
authors: Sezin
authors: S
authors: Unal
authors: Nilgün
authors: N
authors: Altuntaş
authors: Ebru
authors: E
authors: Kazancı
authors: Ferit
authors: F
authors: Kulalı
authors: Canan
authors: C
authors: Turkyılmaz
authors: Yıldız
authors: Y
authors: Atalay
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005712:Galvanic Skin Response; D005865:Gestational Age; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010147:Pain Measurement; D058748:Pain Perception / Q000502:physiology*; D018962:Phlebotomy; D019265:Spectroscopy, Near-Infrared; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins
keywords: glucose; newborn; pain; venipuncture