title: Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia.
abstract: This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric acid, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD. Moreover, individuals with simultaneously high levels of homocysteine and uric acid, both well-known risk factors for cardiovascular disease, had a high probability to be affected by VAD (O.R.:10.50; 95% C.I.: 2.33-47.2), but not LOAD (O.R.: 3.0; 95% C.I.:0.86-10.76) compared with individuals with normal values. Our data suggest that, although they might share a common OxS-related pathogenesis, VAD and LOAD might maintain some distinctive features, with a predominance of "vascular component" in VAD compared with LOAD.
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy. Electronic address: crvcrl@unife.it.
authors: Carlo
authors: C
authors: Cervellati
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy.
authors: Arianna
authors: A
authors: Romani
authors: Gerontology and Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo 71013, Foggia, Italy.
authors: Davide
authors: D
authors: Seripa
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy.
authors: Eleonora
authors: E
authors: Cremonini
authors: Department of Medical Science, Section of Internal Medicine, Gerontology, and Clinical Nutrition, University of Ferrara, 44100 Ferrara, Italy.
authors: Cristina
authors: C
authors: Bosi
authors: Department of Medical Science, Section of Internal Medicine, Gerontology, and Clinical Nutrition, University of Ferrara, 44100 Ferrara, Italy.
authors: Stefania
authors: S
authors: Magon
authors: Department of Medical Science, Section of Internal Medicine, Gerontology, and Clinical Nutrition, University of Ferrara, 44100 Ferrara, Italy.
authors: Angelina
authors: A
authors: Passaro
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy.
authors: Carlo M
authors: CM
authors: Bergamini
authors: Geriatrics Unit, Azienda ULSS 16 Padova, S. Antonio Hospital, 35127 Padova, Italy.
authors: Alberto
authors: A
authors: Pilotto
authors: Department of Medical Science, Section of Internal Medicine, Gerontology, and Clinical Nutrition, University of Ferrara, 44100 Ferrara, Italy.
authors: Giovanni
authors: G
authors: Zuliani
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000503:physiopathology; D000975:Antioxidants; D060825:Cognitive Dysfunction; D015140:Dementia, Vascular / Q000097:blood* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008297:Male; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000502:physiology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014527:Uric Acid / Q000097:blood*
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D006710:Homocysteine; D014527:Uric Acid; D006861:Hydrogen Peroxide
keywords: Dementia; Homocysteine; Late Onset Alzheimer's Disease; Oxidative stress; Uric acid; Vascular Dementia