title: Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels.
abstract: Astaxanthin (AST) is a carotenoid pigment which possesses potent antioxidative, anti-inflammatory, and neuroprotective properties. The aim of this study was to investigate whether administration of AST had protective effects on D-galactose-induced brain aging in rats, and further examined its protective mechanisms. The results showed that AST treatment significantly restored the activities of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), and increased glutathione (GSH) contents and total antioxidant capacity (T-AOC), but decreased malondialdehyde (MDA), protein carbonylation and 8-hydroxy-2- deoxyguanosine (8-OHdG) levels in the brains of aging rats. Furthermore, AST increased the ratio of Bcl-2/Bax, but decreased the expression of Cyclooxygenase-2 (COX-2) in the brains of aging rats. Additionally, AST ameliorated histopathological changes in the hippocampus and restored brain derived neurotrophic factor (BDNF) levels in both the brains and hippocampus of aging rats. These results suggested that AST could alleviate brain aging, which may be due to attenuating oxidative stress, ameliorating hippocampus damage, and upregulating BDNF expression.
authors: College of Food Science and Engineering, Northwest A&F University, 28. Xi-nong Road, Yangling 712100, China. xueboliu@yahoo.com.cn.
authors: Wanqiang
authors: W
authors: Wu
authors: Xin
authors: X
authors: Wang
authors: Qisen
authors: Q
authors: Xiang
authors: Xu
authors: X
authors: Meng
authors: Ye
authors: Y
authors: Peng
authors: Na
authors: N
authors: Du
authors: Zhigang
authors: Z
authors: Liu
authors: Quancai
authors: Q
authors: Sun
authors: Chan
authors: C
authors: Wang
authors: Xuebo
authors: X
authors: Liu
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D024341:Xanthophylls / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D019208:Brain-Derived Neurotrophic Factor; D020011:Protective Agents; D024341:Xanthophylls; D008315:Malondialdehyde; C005948:astaxanthine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D053148:Caspase 3