title: A novel third chromosomal locus controls susceptibility to Autographa californica multiple nucleopolyhedrovirus in the silkworm, Bombyx mori.
abstract: Baculovirus demonstrates specific infection spectrums and thus one certain host exhibits particular response to single baculovirus isolate. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is considered to be not an innate pathogen to Bombyx mori, but some silkworm strains have been identified to be permissive to AcMNPV, indicating the positive or negative involvement of certain host factors in baculovirus replications in vivo. To provide a fundamental knowledge of this process, we performed large-scale screening to investigate the responses of 448 silkworm strains against recombinant AcMNPV inoculation. By genetic analysis between permissive and resistant strains identified, we further confirmed that a potential corresponding locus on chromosome 3 regulates host responses to AcMNPV in silkworm. Additionally, we found that it is available for AcMNPV-silkworm baculovirus expression vector system to produce proteins of interest.
authors: Laboratory of Silkworm Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, 6-10-1 Hakozaki Higashi-ku, Fukuoka, 812-8581, Japan.
authors: Jian
authors: J
authors: Xu
authors: Takahiro
authors: T
authors: Kusakabe
authors: Kimiko
authors: K
authors: Yamamoto
authors: Yoshitaka
authors: Y
authors: Suetsugu
authors: Hiroaki
authors: H
authors: Mon
authors: Zhiqing
authors: Z
authors: Li
authors: Li
authors: L
authors: Zhu
authors: Kazuhiro
authors: K
authors: Iiyama
authors: Yutaka
authors: Y
authors: Banno
authors: Kaito
authors: K
authors: Yoshimura
authors: Jae Man
authors: JM
authors: Lee
mesh_terms: D000818:Animals; D012831:Bombyx / Q000235:genetics* / Q000821:virology*; D017344:Genes, Insect; D056426:Genetic Loci; D005820:Genetic Testing; D017924:Nucleopolyhedroviruses / Q000254:growth & development / Q000502:physiology*; D014779:Virus Replication