title: Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide.
abstract: New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, [M(CO)3 L(x) (py)](+) (where M = Re(I) or (99m) Tc(I) ; L(x)  = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of [M(CO)3 L(x) (py)](+) are reported.
authors: School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Australia.
authors: Timothy U
authors: TU
authors: Connell
authors: David J
authors: DJ
authors: Hayne
authors: Uwe
authors: U
authors: Ackermann
authors: Henri J
authors: HJ
authors: Tochon-Danguy
authors: Jonathan M
authors: JM
authors: White
authors: Paul S
authors: PS
authors: Donnelly
mesh_terms: D057930:Click Chemistry; D008024:Ligands; D009842:Oligopeptides / Q000737:chemistry*; D015609:Organotechnetium Compounds / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D008024:Ligands; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D014230:Triazoles; D012211:Rhenium; D013667:Technetium; C047981:arginyl-glycyl-aspartic acid
keywords: 1,2,3-triazole bidentate ligands; RGD peptide; click chemistry; luminescent Re(CO)3 complexes; rhenium; technetium