title: Early detection of anthracycline-induced cardiotoxicity using two-dimensional speckle tracking echocardiography.
abstract: BACKGROUND
  To examine the subclinical myocardial injury shortly after epirubicin exposure in asymptomatic patients with large B-cell non-Hodgkin lymphoma using 2-dimensional (2D) speckle tracking echocardiography.
  
  
  METHODS
  Sixty-seven patients aged 52.58 ± 13.86 years with large B-cell non-Hodgkin lymphoma treated with epirubicin were studied. Echocardiography was performed at baseline and 1 day after completion of the therapy. Global and regional longitudinal (LS), circumferential (CS) and radial strain (RS), standard deviation of time to peak LS (TLS-SD), CS (TCS-SD), RS(TRS-SD) were calculated using 2D speckle tracking echocardiography.
  
  
  RESULTS
  Despite normal left ventricular ejection fraction, global LS (-18.30 ± 1.87% vs.-16.18 ± 1.92%; p < 0.01), CS (-20.37 ± 2.89% vs. -18.25 ± 2.40%, p < 0.01) and RS (39.95 ± 5.79% vs. 36.15 ± 5.79%, p < 0.01), were remarkably reduced compared to baseline values. However, TLS-SD, TCS-SD and TRS-SD showed no significant difference after epirubicin exposure. Hypertension was an independent predictor of reduction of global LS, CS and RS.
  
  
  CONCLUSIONS
  Subtle abnormalities in myocardial systolic function were present in asymptomatic patients shortly after anthracycline exposure, which could be detected by 2D speckle tracking echocardiography.
authors: Department of Cardiology, Renji Hospital of Jiaotong University, Shanghai, China Department of Echocardiography, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai, China. kang@op.pl.
authors: Yu
authors: Y
authors: Kang
authors: Leilei
authors: L
authors: Cheng
authors: Lin
authors: L
authors: Li
authors: Haiyan
authors: H
authors: Chen
authors: Minmin
authors: M
authors: Sun
authors: Zheng
authors: Z
authors: Wei
authors: Cuizhen
authors: C
authors: Pan
authors: Xianhong
authors: X
authors: Shu
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D058070:Asymptomatic Diseases; D042241:Early Diagnosis; D015251:Epirubicin / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D015588:Observer Variation; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin