title: Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection.
abstract: To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.
authors: La Réunion University Hospital Saint-Denis/Saint-Pierre, La Réunion, France.
authors: Duksha
authors: D
authors: Ramful
authors: Sylvain
authors: S
authors: Sampériz
authors: Xavier
authors: X
authors: Fritel
authors: Alain
authors: A
authors: Michault
authors: Marie-Christine
authors: MC
authors: Jaffar-Bandjee
authors: Olivier
authors: O
authors: Rollot
authors: Brahim
authors: B
authors: Boumahni
authors: Patrick
authors: P
authors: Gérardin
mesh_terms: D000328:Adult; D018354:Alphavirus Infections / Q000097:blood / Q000151:congenital* / Q000276:immunology / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D002646:Chikungunya virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Chikungunya virus; Kaplan-Meier; cohort study; congenital infection; immunization; neonate; pregnancy; serology; serum immunoglobulins G; transplacental transfer