title: CCDC62 variant rs12817488 is associated with the risk of Parkinson's disease in a Han Chinese population.
abstract: It has been recently proposed by a genome-wide association study (GWAS) meta-analysis that the CCDC62 variant rs12817488 is a new risk locus associated with Parkinson's disease (PD). In this study, we aimed to investigate the association between rs12817488 and PD in a Chinese cohort. A total of 341 PD patients and 423 matched controls were recruited in Eastern China. Our results showed that the A allele of rs12817488 was significantly associated with an aggravated risk of PD (p = 0.006) and represented a major allele in contrast to a minor one in Caucasians. Genotype distributions also differed between PD patients and controls (p = 0.011 for AA/AG/GG). Further analysis showed that the association of rs12817488 with PD only existed in females. We also investigated the protein level of CCDC62 in peripheral blood mononuclear cells from 41 AA or GG carriers and found an apparently higher expression in PD patients carrying the AA genotype. A potential interaction was found between two estrogen-related loci, i.e. rs12817488/CCDC62 and rs2697962/PRDM2, particularly in the female stratum. In conclusion, our study demonstrated for the first time a significant association between the rs12817488 polymorphism and PD predisposition in a Chinese population with gender variations and provides new insight regarding the variant's protein expression and estrogen-related genetic interaction.
authors: Department of Neurology, Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors: Rong-Rong
authors: RR
authors: Liu
authors: Li-Li
authors: LL
authors: Zhou
authors: Xing
authors: X
authors: Cheng
authors: Miao-Xuan
authors: MX
authors: Sun
authors: Yan-Bing
authors: YB
authors: Hu
authors: Song-Fang
authors: SF
authors: Chen
authors: Xiong
authors: X
authors: Zhang
authors: Jian-Hong
authors: JH
authors: Zhu
mesh_terms: D017668:Age of Onset; D000483:Alleles; D044466:Asian People / Q000235:genetics; D015153:Blotting, Western; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006579:Heterozygote; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012737:Sex Factors; D014157:Transcription Factors / Q000097:blood* / Q000235:genetics*
chemical_list: C531357:CCDC62 protein, human; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D011495:Histone-Lysine N-Methyltransferase; C093563:PRDM2 protein, human