title: New dimeric members of the phomoxanthone family: phomolactonexanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp.
abstract: Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 1-3 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cytotoxic activities against tested cancer cell lines (IC₅₀ < 10 μM).
authors: Bo
authors: B
authors: Ding
authors: Jie
authors: J
authors: Yuan
authors: Xishan
authors: X
authors: Huang
authors: Weitao
authors: W
authors: Wen
authors: Xu
authors: X
authors: Zhu
authors: Yayue
authors: Y
authors: Liu
authors: Hanxiang
authors: H
authors: Li
authors: Yongjun
authors: Y
authors: Lu
authors: Lei
authors: L
authors: He
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China. tanhm@mail.sysu.edu.cn.
authors: Hongmei
authors: H
authors: Tan
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.
authors: Zhigang
authors: Z
authors: She
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D045325:HCT116 Cells; D006801:Humans; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D044004:Xanthones; C436329:dicerandrol A; C436330:dicerandrol B; C436332:phomoxanthone A; C436333:phomoxanthone B