title: A simple method for the electrophilic cyanation of secondary amines.
abstract: Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.
authors: University of Texas Southwestern Medical Center , Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States.
authors: Chen
authors: C
authors: Zhu
authors: Ji-Bao
authors: JB
authors: Xia
authors: Chuo
authors: C
authors: Chen
mesh_terms: D000588:Amines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D009570:Nitriles