title: Mild bioconjugation through the oxidative coupling of ortho-aminophenols and anilines with ferricyanide.
abstract: Using a small-molecule-based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o-aminophenols on protein substrates. This reaction is compatible with thiols and 1,2-diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.
authors: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460 (USA).
authors: Allie C
authors: AC
authors: Obermeyer
authors: John B
authors: JB
authors: Jarman
authors: Chawita
authors: C
authors: Netirojjanakul
authors: Kareem
authors: K
authors: El Muslemany
authors: Matthew B
authors: MB
authors: Francis
mesh_terms: D000627:Aminophenols / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000627:Aminophenols; D000814:Aniline Compounds; D005292:Ferricyanides; C007931:hexacyanoferrate III; C027667:2-aminophenol; C023650:aniline
keywords: amines; bioconjugation; iron; oxidation; proteins