title: [Intra-uterine death caused by fetal akinesia].
abstract: BACKGROUND
  When two successive pregnancies end in intra-uterine fetal death (IUFD), the question of whether it is coincidental or if there is an underlying abnormality arises. Although diagnostic investigations into the underlying cause are not always carried out after IUFD, they are recommended by the professional body.
  
  
  METHODS
  A 28-year-old female attended our gynaecology outpatient clinic for a second opinion following two intra-uterine fetal deaths. Her own treating physician was of the opinion that there was no connection between the two IUFDs. After a multidisciplinary evaluation, the phenotype fetal akinesia deformation sequence (FADS) was diagnosed in both cases. This is a rare, clinically and aetiologically heterogeneous group of disorders. Thereafter the patient and her husband were offered specific pre-conception counseling.
  
  
  CONCLUSIONS
  Every IUFD justifies systemic and multidisciplinary investigation to determine any underlying aetiology such as FADS. This may contribute to better pre-conception advice and prenatal individualised diagnostics in a subsequent pregnancy.
authors: Spaarne Ziekenhuis, afd. Gynaecologie, Hoofddorp.
authors: Renée
authors: R
authors: Out
authors: P C M Pieter-Kees
authors: PC
authors: de Groot
authors: M B Gita
authors: MB
authors: Tan-Sindhunata
authors: J I P Hanneke
authors: JI
authors: de Vries
mesh_terms: D000328:Adult; D001176:Arthrogryposis / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005313:Fetal Death / Q000175:diagnosis / Q000209:etiology*; D005324:Fetal Movement / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy