title: Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer.
abstract: Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.
authors: Department of Obstetrics and Gynecology, Bethune International Peace Hospital , Shijiazhuang, Hebei , People's Republic of China .
authors: Meixiang
authors: M
authors: Sang
authors: Xiaohua
authors: X
authors: Wu
authors: Xiaojie
authors: X
authors: Fan
authors: Meijie
authors: M
authors: Sang
authors: Xinliang
authors: X
authors: Zhou
authors: Nan
authors: N
authors: Zhou
mesh_terms: D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D058950:Melanoma-Specific Antigens / Q000097:blood* / Q000235:genetics; D015999:Multivariate Analysis; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000097:blood* / Q000401:mortality / Q000556:secondary; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology
chemical_list: D018394:CA-125 Antigen; D058950:Melanoma-Specific Antigens