title: Progesterone regulates secretin expression in mouse uterus during early pregnancy.
abstract: Secretin, a classical gastrointestinal and neuroendocrine peptide, plays an important role in maintaining the body fluid balance. However, the expression and regulation of secretin in the reproductive system are still unknown. In our study, secretin is specifically expressed in the decidua on days 5 to 8 of pregnancy. Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization. Progesterone induces secretin expression in ovariectomized mice and cultured stromal cells, which is abrogated by specific LY294002. Because secretin is mainly localized in the decidua and also strongly expressed during in vitro decidualization, secretin may play a role during mouse decidualization through regulating cyclic adenosine monophosphate level.
authors: 1School of Life Science, Xiamen University, Xiamen, China.
authors: Zhu
authors: Z
authors: Huang
authors: Tong-Song
authors: TS
authors: Wang
authors: Qian-Rong
authors: QR
authors: Qi
authors: Ru-Juan
authors: RJ
authors: Zuo
authors: Xiao-Huan
authors: XH
authors: Liang
authors: Xu-Yu
authors: XY
authors: Zhao
authors: Zeng-Ming
authors: ZM
authors: Yang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology* / Q000502:physiology; D012633:Secretin / Q000096:biosynthesis*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D012633:Secretin; D011374:Progesterone
keywords: decidualization; embryo implantation; progesterone; secretin; uterus