title: First case of 18F-FACBC PET/CT-guided salvage retroperitoneal lymph node dissection for disease relapse after radical prostatectomy for prostate cancer and negative 11C-choline PET/CT: new imaging techniques may expand pioneering approaches.
abstract: We present the first case of salvage retroperitoneal lymph node dissection based on the results of (18)F-FACBC PET/CT performed for a prostate-specific antigen relapse after radical prostatectomy. The patients underwent (11)C-choline PET/CT, which turned out negative, while (18)F-FACBC PET/CT visualized two lymph node metastases confirmed at pathological examination. Preliminary clinical reports showed an improvement in the detection rate of 20-40% for (18)F-FACBC in comparison with (11)C-choline, rendering the (18)F-FACBC the potential radiotracer of the future. Salvage surgery for prostate cancer is a fascinating but controversial approach. New diagnostic tools may improve its potential by increasing the assessment and the selection of the patients.
authors: Department of Urology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors: Riccardo
authors: R
authors: Schiavina
authors: Sergio
authors: S
authors: Concetti
authors: Eugenio
authors: E
authors: Brunocilla
authors: Cristina
authors: C
authors: Nanni
authors: Marco
authors: M
authors: Borghesi
authors: Giorgio
authors: G
authors: Gentile
authors: Matteo
authors: M
authors: Cevenini
authors: Lorenzo
authors: L
authors: Bianchi
authors: Enrico
authors: E
authors: Molinaroli
authors: Stefano
authors: S
authors: Fanti
authors: Giuseppe
authors: G
authors: Martorana
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002794:Choline / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry*; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D049268:Positron-Emission Tomography / Q000379:methods; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D016879:Salvage Therapy / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D003503:Cyclobutanes; C117460:fluciclovine F-18; D017430:Prostate-Specific Antigen; D002794:Choline