title: Synthesis and antibacterial activity of novel 5,5'-(pyridine-2,6-diyl)bis(4-arylideneamino-3-mercapto-1,2,4-triazole)-related derivatives.
abstract: The reaction of 5,5'-(pyridine-2,6-diyl)bis(4-amino-3-mercapto-1,2,4-triazole) with various aromatic aldehydes in acetic acid yielded the corresponding 5,5'-(pyridine-2,6-diyl)bis(4-arylideneamino-3-mercapto-1,2,4-triazole) derivatives. The structures of the synthesized compounds as well as their intermediates were confirmed by elemental analysis, infrared spectra, (1)H NMR spectra and mass spectra studies. All the synthesized title compounds were screened for their antibacterial activities, and the preliminary results revealed that some of them showed good activities against Escherichia coli and Pseudomonas aeruginosa.
authors: College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
authors: Haihua
authors: H
authors: Xiao
authors: Pingliang
authors: P
authors: Li
authors: Jinhui
authors: J
authors: Hu
authors: Ruixia
authors: R
authors: Li
authors: Limin
authors: L
authors: Wu
authors: Dongcai
authors: D
authors: Guo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010848:Picolinic Acids / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010848:Picolinic Acids; D014230:Triazoles; C045575:1,2,4-triazole; C004860:dipicolinic acid