title: The effects of dexamethasone and levobupivacaine on postoperative pain in modified radiofrequency assisted uvulopalatoplasty (MRAUP) surgery.
abstract: The objective of this prospective, randomized study was to evaluate the effect of pre-emptive local infiltration of lidocaine, lidocaine plus dexamethasone, levobupivacaine and levobupivacaine plus dexamethasone on postoperative pain in Modified Radiofrequency Assisted Uvulopalatoplasty (MRAUP) cases. Sixty adult patients (44 males and 16 females) aged 32-51 years with simple snoring were divided into four groups. The anesthesia of the patients in the first group was achieved with lidocaine HCl, in the second group, with lidocaine HCl and dexamethasone sodium phosphate, in the third group, with levobupivacaine, and in the fourth group, levobupivacaine and dexamethasone sodium phosphate. All the patients were applied Modified Radiofrequency Assisted Uvulopalatoplasty technique. The pain experienced by the patients during swallowing and at rest on the 1st, 3rd, 5th, 7th, and 10th day and analgesic consumption were evaluated using standard 10 cm visual analog scales. The mean duration of operation in the group that received lidocaine HCl was 22 ± 3 min, while in the group that received levobupivacaine HCl was 27 ± 4 min. There were statistically significant differences between the groups for analgesic effects on the 1st, 3rd, 5th, and 7th day and for the amount of analgesics used, on the 1st, 3rd, and 5th day. The best results were obtained in the group that received levobupivacaine HCl and steroid (p < 0.001). Steroid and local anesthetic combinations are superior to controls in the management of postoperative pain in MRAUP surgery.
authors: Department of Otorhinolaryngology and Head and Neck Surgery, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors: Arzu Onder
authors: AO
authors: Tatar
authors: Ozgur
authors: O
authors: Yoruk
authors: Metin
authors: M
authors: Akgun
mesh_terms: D000328:Adult; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002045:Bupivacaine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077554:Levobupivacaine; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D010160:Palate, Soft / Q000601:surgery; D000078702:Radiofrequency Therapy; D012913:Snoring / Q000601:surgery*; D014609:Uvula / Q000601:surgery*
chemical_list: D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008012:Lidocaine; D000077554:Levobupivacaine; D002045:Bupivacaine