title: [Preoperative chemotherapy in the surgical treatment of colorectal liver metastases].
abstract: BACKGROUND
  The only curative treatment of colorectal liver metastases (CRLM) is surgical resection. Preoperative/neoadjuvant chemotherapy can be used for resectable, for borderline resectable or even for irresectable CRLM patients.
  
  
  METHODS
  Data of CRLM patients treated with surgical resection at the Uzsoki Hospital were analysed. Patients were classified into two groups, (A) who received preoperative chemotherapy before hepatic resection, and (B) who received no chemotherapy before resection.
  
  
  RESULTS
  Between 01.01.2007. and 31.12.2010. 128 CRLM patients were treated with hepatic resection. 68 patients (53%) received chemotherapy before hepatic resection, 60 patients (47%) were resected without neoadjuvant chemotherapy. There was no significant difference in the complications between the groups (p = 0.39). Median overall survival was 41 months. The progression free survival (PFS) at 3 and 5 years were 25%, the 3 and 5 year overall survival (OS) were 55% and 31%. Both PFS and OS were significantly worse in the chemotherapy group (p = 0.014, p = 0.015). The subgroup of patients receiving bevacizumab containing preoperative chemotherapy has significanly better PFS than patients receiving only cytotoxic chemotherapy (p = 0.004).
  
  
  CONCLUSIONS
  Surgical resection of CRLM patients results good survival data even in non-selected patients, although the very long survival results reported in the literature couldn't have been reproduced in this patient population. When preoperative chemotherapy was combined with bevacizumab, survival was similar to the upfront resected patients.
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: Kristóf
authors: K
authors: Dede
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: István
authors: I
authors: Láng
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: Balázs
authors: B
authors: Pörneczi
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: Gábor
authors: G
authors: Mester
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: András
authors: A
authors: Fekete
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: György
authors: G
authors: Kőszegi
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: Tamás
authors: T
authors: Mersich
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: István
authors: I
authors: Besznyák
authors: Uzsoki Utcai Kórház Sebészeti Osztály 1145 Budapest Uzsoki u. 29.
authors: Attila
authors: A
authors: Bursics
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005492:Folic Acid / Q000008:administration & dosage; D006498:Hepatectomy / Q000379:methods; D006769:Hospitals, General / Q000706:statistics & numerical data; D006801:Humans; D000077146:Irinotecan; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D061646:Operative Time; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013503:Surgery Department, Hospital / Q000706:statistics & numerical data; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000068258:Bevacizumab; D000077146:Irinotecan; D005492:Folic Acid; D005472:Fluorouracil; D002166:Camptothecin
keywords: colorectal liver metastasis; colorectalis májáttét; liver resection; májresectio; neoadjuvant chemotherapy; preoperatív/neoadjuváns kemoterápia