title: Neuromyelitis optica spectrum disorder complicated with Sjogren syndrome successfully treated with tocilizumab: A case report.
abstract: A 38-year-old woman with relapsing longitudinal extensive transverse myelitis and Sjogren's syndrome (SS) was admitted with lower extremity muscle weakness. Studies showed high serum titer of anti-aquaporin4 antibody and gadolinium-enhanced-MRI T1-weighted lesions within thoracic cord. Clinical findings suggested neuromyelitis optica-spectrum disorder (NMO-SD). High-dose corticosteroids, plasma exchange and cyclophosphamide were not effective. After starting tocilizumab, her neurological findings gradually improved. This report describes the first evidence to show tocilizumab could be effective for NMO-SD with SS.
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Toshihiko
authors: T
authors: Komai
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Hirofumi
authors: H
authors: Shoda
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Kenichi
authors: K
authors: Yamaguchi
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Keiichi
authors: K
authors: Sakurai
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Mihoko
authors: M
authors: Shibuya
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Kanae
authors: K
authors: Kubo
authors: b Department of Neurology , Tohoku University Graduate School of Medicine , Sendai, Miyagi , Japan.
authors: Toshiyuki
authors: T
authors: Takahashi
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Keishi
authors: K
authors: Fujio
authors: a Department of Allergy and Rheumatology , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D009188:Myelitis, Transverse / Q000097:blood / Q000150:complications* / Q000276:immunology; D009471:Neuromyelitis Optica / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D010956:Plasmapheresis; D012008:Recurrence; D019233:Retreatment; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D051401:Aquaporin 4; D001323:Autoantibodies; D007155:Immunologic Factors; D003520:Cyclophosphamide; C502936:tocilizumab
keywords: Anti-aquaporin4 antibody; Neuromyelitis optica; Sjogren's syndrome; Tocilizumab; Transverse myelitis