title: Modulating effect of Allium cepa on kidney apoptosis caused by Toxoplasma gondii.
abstract: OBJECTIVE
  Toxoplasma gondii is a widespread protozoan parasite that infects a broad range of warm blooded animals as well as humans. The present study was investigated to evaluate the effects of allium cepa on renal failur in male rats which experimentally infected by Toxoplasma gondii, RH strain.
  
  
  METHODS
  Wistar male rat (n=40) were allocated into four groups, group one that received tachyzoites of T. gondii (ip) (n=10), group two that received tachyzoites of T. gondii (ip), plus fresh onion juice by gavages method (n=10), group three received just fresh onion juice by gavages method (n=10) and control group (n=10) that received nothing. Animals were kept in standard condition. In 30 day after inducing Toxoplasma infection, 5cc blood was collected for serum protein and TAC levels. Kidney tissues of Rat in whole groups were removed and prepared for apopetosis analysis.
  
  
  RESULTS
  Serum protein and kidneys weights were significantly decreased in groups that were infected with T. gondii, in comparison to control and onions groups. Kidneys Apopetosis in toxoplasma group significantly increased in comparison to control group (P<0.05).level of TAC was significantly increased in groups that received onio juice (P<0.05).
  
  
  CONCLUSIONS
  This study showed that T. gondii have significantly effect on serum protein and TAC, apopetosis and fresh onion juice returned and treated this harmful effect, so it is suggested that eating of onion is useful in toxoplasma infection.
authors: Department of Parisitology,Tabriz Branch,Islamic Azad University, Tabriz, Iran.
authors: Yaghub
authors: Y
authors: Gharadaghi
authors: Saeedeh
authors: S
authors: Shojaee
authors: Arash
authors: A
authors: Khaki
authors: Amir
authors: A
authors: Hatef
authors: Hamid Reza
authors: HR
authors: Ahmadi Ashtiani
authors: Hossin
authors: H
authors: Rastegar
authors: Fatemeh
authors: F
authors: Fathiazad
keywords: Allium cepa; Apoptosis; Kidney; Protein; Toxoplasma gondii