title: On best practices: the Institute of Medicine scheme for developing, validating, and demonstrating clinical utility of omics-based diagnostic and predictive tests.
abstract: The Institute of Medicine of the US National Academy of Sciences issued a major report in 2012 that provides important guidance for the proteomics community for credible and transparent development of all kinds of omics-based diagnostic and prognostic tests. The key elements are summarized here to provide a compass that can guide the studies emerging from many laboratories as reported in this special issue of Proteomics Clinical Applications on "Diagnostic Proteomics."
authors: Departments of Computational Medicine and Bioinformatics, Internal Medicine, and Human Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Institute for Systems Biology, Seattle, WA, USA.
authors: Gilbert S
authors: GS
authors: Omenn
mesh_terms: D006801:Humans; D015969:National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division; D040901:Proteomics / Q000379:methods*; D014481:United States
keywords: Diagnostics; Institute of Medicine; Omics; Tests