title: The synthesis and structure revision of NSC-134754.
abstract: The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.
authors: CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. keith.jones@icr.ac.uk.
authors: Jennie A
authors: JA
authors: Hickin
authors: Afshan
authors: A
authors: Ahmed
authors: Katharina
authors: K
authors: Fucke
authors: Margaret
authors: M
authors: Ashcroft
authors: Keith
authors: K
authors: Jones
mesh_terms: D001681:Biological Assay; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D008156:Luciferases; D008958:Models, Molecular
chemical_list: D007546:Isoquinolines; C502338:NSC-134754; D008156:Luciferases