title: [Selection pressure analysis of H3N2 influenza virus from China between 1992 and 2012].
abstract: OBJECTIVE
  In order to investigate the relationship between selection pressure and the prevalence of antigenic clusters, we sequenced and analyzed the H3N2 influenza virus from China between 1992 and 2012.
  
  
  METHODS
  The H3N2 influenza virus (n = 1206) in China from 1992 to 2012 was analyzed, include global selection pressure and sites positive selection pressure analysis.
  
  
  RESULTS
  Considering all the H3N2 influenza viruses during these 21 years, a total of four amino acid sites subject to positive selection. The global selection pressure varies with the variation of different antigenic clusters and three years with peak bottom selection pressure were identified.
  
  
  CONCLUSIONS
  The global selection pressure rise from the peak bottom, a new antigenic clusters will appear andprevalent in the population, indicating the best time to replace the vaccine strain.
authors: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing.
authors: Yu
authors: Y
authors: Lan
authors: Xiang
authors: X
authors: Zhao
authors: Xi-Yan
authors: XY
authors: Li
authors: Ye
authors: Y
authors: Zhang
authors: Jun-Feng
authors: JF
authors: Guo
authors: Ming
authors: M
authors: Li
authors: Wei-Juan
authors: WJ
authors: Huang
authors: He-Jiang
authors: HJ
authors: Wei
authors: Yan-Hui
authors: YH
authors: Cheng
authors: Min-Ju
authors: MJ
authors: Tan
authors: Zhao
authors: Z
authors: Wang
authors: Lei
authors: L
authors: Yang
authors: Ning
authors: N
authors: Xiao
authors: Da-Yan
authors: DY
authors: Wang
authors: Yue-Long
authors: YL
authors: Shu
mesh_terms: D000956:Antigens, Viral / Q000276:immunology; D002681:China; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics* / Q000276:immunology; D007252:Influenza Vaccines; D012641:Selection, Genetic; D013997:Time Factors
chemical_list: D000956:Antigens, Viral; D007252:Influenza Vaccines