title: Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.
abstract: Previous studies have revealed that expression of allograft inflammatory factor-1 (AIF-1) protein appears to be increased in malignancies and is correlated with a poorer prognosis in cervical cancer, while its role in gastric cancer has not been reported. We analyzed the expression of AIF-1 in 78 cancer lesions and the corresponding non-cancerous tissues by immunohistochemistry. In contrast with other cancers, we found that AIF-1 protein levels were significantly decreased in 53 of the 78 (67.9%) gastric cancer tissues when compared with the matched normal tissues. This was further confirmed using 7 pairs of fresh gastric cancer tissues and matched adjacent normal tissues. Low tumoral AIF-1 expression was significantly correlated with less favorable clinicopathological characteristics, as well as with reduced overall survival (P<0.001) in the gastric cancer patients. Furthermore, knockdown of AIF-1 obviously increased proliferation, migration and β-catenin expression in BGC-823 and SGC-7901 gastric cancer cells. Taken together, for the first time, we provide evidence that the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
authors: Department of Preventive Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
authors: Yang
authors: Y
authors: Ye
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Shuhan
authors: S
authors: Miao
authors: Department of Preventive Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
authors: Rongzhu
authors: R
authors: Lu
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Xiaowei
authors: X
authors: Xia
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Yansu
authors: Y
authors: Chen
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Jianbing
authors: J
authors: Zhang
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Xuming
authors: X
authors: Wu
authors: Department of Pathology, Nantong Cancer Hospital, Nantong, Jiangsu 226361, P.R. China.
authors: Song
authors: S
authors: He
authors: Department of Pathology, Nantong Cancer Hospital, Nantong, Jiangsu 226361, P.R. China.
authors: Fulin
authors: F
authors: Qiang
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Jianwei
authors: J
authors: Zhou
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008840:Microfilament Proteins; D011379:Prognosis; D034622:RNA Interference; D034741:RNA, Small Interfering; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality; D013534:Survival; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D051176:beta Catenin / Q000096:biosynthesis*
chemical_list: C112986:AIF1 protein, human; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D008840:Microfilament Proteins; D034741:RNA, Small Interfering; D025521:Tumor Suppressor Proteins; D051176:beta Catenin