title: [Three cases of bullous lupus erythematosus].
abstract: BACKGROUND
  Bullous lupus is a subepidermal autoimmune bullous dermatosis, a rare entity that forms one of the cutaneous signs of systemic lupus erythematosus. We report on the clinical, immunopathological and progressive features of bullous lupus in three patients.
  
  
  METHODS
  Our patients consisted of two women and one man aged 34, 22 and 30 years respectively. A diagnosis of bullous lupus erythematosus was evoked by blisters or vesicular blisters and confirmed, in addition to criteria for the diagnosis of systemic lupus erythematosus, by the presence of subepidermal blistering with infiltrate containing neutrophils and eosinophils as revealed by histological analysis, and of deposits of IgG and IgM (two cases) or of IgA (one case) at the dermo-epidermal junction observed under direct immunofluorescence. Indirect immunofluorescence showed anti-collagen VII antibodies. Lupus nephritis was present in two cases. Our patients were treated with corticosteroids and immunosuppressants.
  
  
  CONCLUSIONS
  Bullous lupus erythematosus may be the first sign of systemic lupus erythematosus with severe visceral involvement, especially renal involvement, suggesting that it may be a marker of activity and prognosis.
authors: Service de médecine interne B, hôpital militaire d'instruction Mohammed V, avenue des Far, Hay Riad, Rabat, Maroc. Electronic address: jiramohamed@yahoo.fr.
authors: M
authors: M
authors: Jira
authors: M
authors: M
authors: Elqatni
authors: Y
authors: Y
authors: Sekkach
authors: N
authors: N
authors: Elomri
authors: F
authors: F
authors: Mekouar
authors: D
authors: D
authors: Ghafir
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis; D001768:Blister / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D003094:Collagen / Q000276:immunology; D003937:Diagnosis, Differential; D018450:Disease Progression; D003875:Drug Eruptions / Q000175:diagnosis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008181:Lupus Nephritis / Q000209:etiology; D008297:Male; D020556:Neutrophil Infiltration; D019226:Oral Ulcer / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000276:immunology / Q000473:pathology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents; D003094:Collagen; D011241:Prednisone
keywords: Anti-collagen VII antibody; Anticorps anti-collagène VII; Bulle sous-épidermique; Bullous lupus erythematosus; Lupus érythémateux bulleux; Sub-epidermal blistering