title: Notch2 transduction by feline leukemia virus in a naturally infected cat.
abstract: Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.
authors: Laboratory of Molecular Immunology and Infectious Disease, United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
authors: Shinya
authors: S
authors: Watanabe
authors: Jumpei
authors: J
authors: Ito
authors: Takuya
authors: T
authors: Baba
authors: Takahiro
authors: T
authors: Hiratsuka
authors: Kyohei
authors: K
authors: Kuse
authors: Haruyo
authors: H
authors: Ochi
authors: Yukari
authors: Y
authors: Anai
authors: Masaharu
authors: M
authors: Hisasue
authors: Hajime
authors: H
authors: Tsujimoto
authors: Kazuo
authors: K
authors: Nishigaki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002371:Cat Diseases / Q000235:genetics* / Q000821:virology*; D002415:Cats; D003001:Cloning, Molecular; D017931:DNA Primers / Q000235:genetics; D005260:Female; D040461:Gene Components; D015752:Genes, env / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D005256:Leukemia Virus, Feline / Q000235:genetics / Q000502:physiology*; D016582:Leukemia, Feline / Q000235:genetics* / Q000821:virology; D008156:Luciferases; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D051883:Receptor, Notch2 / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000662:veterinary; D014161:Transduction, Genetic / Q000662:veterinary*
chemical_list: D017931:DNA Primers; D051883:Receptor, Notch2; D008156:Luciferases