title: Hot flushes in women with breast cancer: state of the art and future perspectives.
abstract: Although not life-threatening, vasomotor symptoms might have a detrimental effect on quality of life and represent a major determinant of poor therapeutic compliance in breast cancer patients. Limitations of hormonal therapies have fostered the use of non-estrogenic pharmacological agents, which mainly include centrally acting compounds, antidepressant drugs, serotonin-norepinephrine reuptake inhibitors and serotonin reuptake inhibitors. Integrating therapeutic tools have recently come from a wide range of heterogeneous approaches varying from phytoestrogens use to ganglion block. We herein critically review the most updated evidence on the available treatment options for management of vasomotor symptoms. The need for a patient-oriented approach following systematic evaluation of the presence and degree of vasomotor disturbances is also discussed and future perspectives in therapeutics are summarized.
authors: Medical Oncology B-Scientific Direction, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
authors: Maddalena
authors: M
authors: Barba
authors: Laura
authors: L
authors: Pizzuti
authors: Domenico
authors: D
authors: Sergi
authors: Marcello
authors: M
authors: Maugeri-Saccà
authors: Cristina
authors: C
authors: Vincenzoni
authors: Francesca
authors: F
authors: Conti
authors: Federica
authors: F
authors: Tomao
authors: Enrico
authors: E
authors: Vizza
authors: Luigi
authors: L
authors: Di Lauro
authors: Franco
authors: F
authors: Di Filippo
authors: Silvia
authors: S
authors: Carpano
authors: Luciano
authors: L
authors: Mariani
authors: Patrizia
authors: P
authors: Vici
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D055118:Medication Adherence; D011788:Quality of Life