title: Synthesis and biological evaluation of fatty acids conjugates bearing cyclopentadienyl-donors incorporated [(99m)Tc/Re(CO)3]+ for myocardical imaging.
abstract: Four (99m)Tc-labeled fatty acid analogs, 1b, 2b, 3b, 4b were synthesized by a double ligand transfer reaction and theirs potential were investigated. The radiochemical yield of the radiotracers was from 11.7% to 30.3% (no decay corrected). Those compounds were found to be chemically stable when incubated in SD rat serum for 3 h at 37 °C. The biodistribution studies in mice showed that high radioactivity accumulated of Tc-99m complexes were observed, followed by moderate clearance from the heart. The maximum heart/blood ratio was 5.7 at 15 min postinjection of 1b. Metabolite analysis showed 1b was not metabolized by β-oxidation in the heart. These results suggest that 1b may be a promising radiotracer for evaluation of myocardial viability.
authors: Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China; Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: huahuizeng@gmail.com.
authors: Huahui
authors: H
authors: Zeng
authors: Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China. Electronic address: hbzhang@bnu.edu.cn.
authors: Huabei
authors: H
authors: Zhang
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D055414:Myocardial Perfusion Imaging; D009206:Myocardium / Q000378:metabolism*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012211:Rhenium / Q000737:chemistry; D013667:Technetium / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D003517:Cyclopentanes; D005227:Fatty Acids; D009942:Organometallic Compounds; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals; D012211:Rhenium; D013667:Technetium; D002248:Carbon Monoxide
keywords: Fatty acid; Myocardial imaging; Technetium-99m; Tissue distribution