title: Risk factors for wound infection in surgery for spinal metastasis.
abstract: Wound infection rates are generally higher in patients undergoing surgery for spinal metastasis. Risk factors of wound infection in these patients are poorly understood.
  
  
  OBJECTIVE
  To identify demographic and clinical variables that may be associated with patients experiencing a higher wound infection rate.
  
  
  METHODS
  Retrospective study with prospectively collected data of spinal metastasis patients operated consecutively at a University Teaching Hospital, adult spine division which is a tertiary referral centre for complex spinal surgery.
  
  
  METHODS
  Ninety-eight patients were all surgically treated, consecutively from January 2009 to September 2011. Three patients had to be excluded due to inadequate data.
  
  
  METHODS
  Physiological measures, with presence or absence of microbiologically proven infection.
  
  
  METHODS
  Various demographic and clinical data were recorded, including age, serum albumin level, blood total lymphocyte count, corticosteroid intake, Malnutrition Universal Screening Tool (MUST) score, neurological disability, skin closure material used, levels of surgery and administration of peri-operative corticosteroids. No funding was received from any sources for this study and as far as we are aware, there are no potential conflict of interest-associated biases in this study.
  
  
  RESULTS
  Higher probabilities of infection were associated with low albumin level, seven or more levels of surgery, use of delayed/non-absorbable skin closure material and presence of neurological disability. Of these factors, levels of surgery were found to be statistically significant at the 5 % significance level.
  
  
  CONCLUSIONS
  Risk of infection is high (17.9 %) in patients undergoing surgery for spinal metastasis. Seven or more vertebral levels of surgery increase the risk of infection significantly (p < 0.05). Low albumin level and presence of neurological disability appear to show a trend towards increased risk of infection. Use of absorbable skin closure material, age, low lymphocyte count, peri-operative administration of corticosteroids and MUST score do not appear to influence the risk of infection.
authors: Department of Spinal Surgery, Salford Royal Hospital NHS Foundation Trust, Stott Lane, Lancashire, M6 8HD, UK.
authors: S
authors: S
authors: Kumar
authors: D
authors: D
authors: van Popta
authors: R
authors: R
authors: Rodrigues-Pinto
authors: J
authors: J
authors: Stephenson
authors: S
authors: S
authors: Mohammad
authors: I
authors: I
authors: Siddique
authors: R R
authors: RR
authors: Verma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D013125:Spinal Neoplasms / Q000556:secondary* / Q000601:surgery*; D013530:Surgical Wound Infection / Q000209:etiology*