title: Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits.
abstract: OBJECTIVE
  The aim of our study was to investigate the functional roles of H3R agonist and antagonist in the development of hepatic functions impairment in immunized rabbits.
  
  
  METHODS
  The study comprised of six groups containing 18 rabbits in each. Group-I (negative control) and group-II (positive control) received sterile distilled water intramuscularly while Group III-VI received histamine (100 µgkg-1, s.c.), R-[-]-α-methylhistamine (H3R-agonist, 10 µgkg-1, s.c.), iodophenpropit (H3R-antagonist, 1 µgkg-1, i.m.), and the combination of iodophenpropit (1 µgkg-1, i.m.) plus histamine (100 µgkg-1, s.c.), respectively, b.i.d. (12 hours [8 am and 8 pm]) for 10 days. Groups II-VI were immunized on day 3 with intravenous injection of sheep red blood cells (1×109 cells/ml).
  
  
  RESULTS
  On each experimental day, the mean values of serum enzymes and bilirubin in group-I and group-II showed no changes while in groups III, IV, V, and VI, these enzymes and bilirubin levels showed significant changes (p<0.05), when compared with their values within the group. Profile of ALT and AST production revealed that ALT and AST levels moderately were changed due to degeneration of the liver.
  
  
  CONCLUSIONS
  Our results suggest that R-[-]-α-methylhistamine showed moderate, and histamine and iodophenpropit showed mild degeneration of liver functions; while iodophenpropit plus histamine showed hepatic functions similar to control group. This study suggests that H3R antagonist in combination with histamine may be a non-toxic therapeutic target for histamine research (Fig. 7, Ref. 28). Text in PDF www.elis.sk.
authors: T
authors: T
authors: Tripathi
authors: A A
authors: AA
authors: Khan
authors: M
authors: M
authors: Shahid
authors: V
authors: V
authors: Dwivedi
authors: S
authors: S
authors: Sarkar
authors: M
authors: M
authors: Siddiqui
authors: H M
authors: HM
authors: Khan
authors: A A
authors: AA
authors: Mahdi
authors: R A
authors: RA
authors: Khan
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D017442:Histamine Agonists / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology*; D007114:Immunization / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D011817:Rabbits
chemical_list: D017442:Histamine Agonists; D006633:Histamine Antagonists; D001663:Bilirubin
keywords: histamine, histamine H3 receptor, agonist, antagonist, R-[-]-α-methylhistamine, iodophenpropit, liver function test.