title: 8-Oxo-2'-deoxyguanosine ameliorates features of metabolic syndrome in obese mice.
abstract: Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose and liver tissue, frequently involved in insulin resistance. 8-Oxo-2'-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages. In this study, we explored whether 8-Oxo-dG suppressed a series of systemic inflammatory cascades, resulting in the amelioration of typical features of metabolic syndrome in obese mice. The results demonstrate that 8-Oxo-dG effectively improved hyperglycemia, dyslipidemia and fatty liver changes in obese mice. The level of biochemical markers indicative of systemic inflammation were reduced in 8-Oxo-dG treated mice, whereas serum levels of adiponectin, a crucial factor associated with improved metabolic syndrome, were enhanced. Our results demonstrate that 8-Oxo-dG effectively disrupts the pathogenesis of insulin resistance and obesity-associated metabolic syndrome.
authors: Department of Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Seoul 140-742, South Korea.
authors: Seong-Hee
authors: SH
authors: Ko
authors: Department of Pharmacology and Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, South Korea; Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Seoul 110-799, South Korea; Department of Anatomy and Cell Biology, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
authors: Jin-Ku
authors: JK
authors: Lee
authors: Department of Pharmacology and Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, South Korea; Major in Medicine, Pusan University School of Medicine, Busan 602-739, South Korea.
authors: Hyun Joo
authors: HJ
authors: Lee
authors: Department of Pharmacology and Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, South Korea; Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Sang-Kyu
authors: SK
authors: Ye
authors: Department of Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Seoul 140-742, South Korea.
authors: Hyun-Sook
authors: HS
authors: Kim
authors: Department of Pharmacology and Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, South Korea; Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea. Electronic address: mhchung@snu.ac.kr.
authors: Myung-Hee
authors: MH
authors: Chung
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D024821:Metabolic Syndrome / Q000276:immunology* / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000276:immunology* / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-Oxo-deoxyguanosine; Inflammation; Insulin resistance; Metabolic syndrome