title: Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction.
abstract: A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line.
authors: Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
authors: Pori
authors: P
authors: Buragohain
authors: Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
authors: Bishwajit
authors: B
authors: Saikia
authors: Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
authors: Naresh
authors: N
authors: Surineni
authors: Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
authors: Nabin C
authors: NC
authors: Barua
authors: Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
authors: Ajit K
authors: AK
authors: Saxena
authors: Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
authors: Nitasha
authors: N
authors: Suri
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; C031327:artemisinin
keywords: Anticancer; Artemisinin; Artemisinin dimer; Dihydroartemisinin; Sonogashira cross-coupling