title: Relationship of body fat weight and body fat ratio determined by bioelectric impedance to serum adipocytokines in patients with type 2 diabetes mellitus.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  Various adipocytokines are closely associated with both obesity and insulin resistance. We investigated how body fat weight (BFW) and body fat ratio (BFR) affected serum adipocytokines in patients with type 2 diabetes mellitus.
  
  
  METHODS
  Studies were conducted in type 2 diabetic patients (n = 41) and age-matched healthy subjects (n = 18). BFW and BFR were determined using a high-frequency bioelectric impedance method. We measured the adipocytokines such as leptin, adiponectin, and tumor necrosis factor (TNF)-α in serum.
  
  
  RESULTS
  BFW and BFR showed significant positive correlations with BMI and serum leptin concentrations in diabetic patients. A significant positive correlation was found between BFW and serum FFA. Multivariate analysis identified only BMI a significant independent determinant of BFW. Stepwise analysis disclosed a significant positive correlation between HOMA-R and serum leptin.
  
  
  CONCLUSIONS
  In diabetic patients, accumulation of body fat may increase serum leptin and FFA, which in turn would contribute to insulin resistance.
authors: Rika
authors: R
authors: Naruse
authors: Yoshihisa
authors: Y
authors: Inukai
authors: Tomoko
authors: T
authors: Terasawa
authors: Kenji
authors: K
authors: Hara
authors: Kohzo
authors: K
authors: Takebayashi
authors: Mikio
authors: M
authors: Morita
authors: Yoshimasa
authors: Y
authors: Aso
authors: Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, 2-1-50, Minami-Koshigaya, Koshigaya 343-8555, Japan. Electronic address:t-inukai@dokkyomed.ac.jp.
authors: Toshihiko
authors: T
authors: Inukai