title: A pyrene derivative for Hg(2+) -selective fluorescent sensing and its application in in vivo imaging.
abstract: An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.
authors: Key Laboratory of Medicinal Chemistry for Natural Resource, School of Chemical Science and Technology, Yunnan University, Kunming 650091 (China), Fax: (+86) 871-65033679.
authors: Guang Ke
authors: GK
authors: Wang
authors: Qi Li
authors: QL
authors: Mi
authors: Li Yun
authors: LY
authors: Zhao
authors: Jun Jie
authors: JJ
authors: Hu
authors: Lin E
authors: LE
authors: Guo
authors: Xiao Ju
authors: XJ
authors: Zou
authors: Bo
authors: B
authors: Liu
authors: Xiao Guang
authors: XG
authors: Xie
authors: Jun Feng
authors: JF
authors: Zhang
authors: Qi Hua
authors: QH
authors: Zhao
authors: Ying
authors: Y
authors: Zhou
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism; D005456:Fluorescent Dyes / Q000032:analysis* / Q000138:chemical synthesis* / Q000737:chemistry; D008628:Mercury / Q000032:analysis*; D015394:Molecular Structure; D011721:Pyrenes / Q000138:chemical synthesis / Q000737:chemistry*; D015027:Zebrafish / Q000033:anatomy & histology / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D011721:Pyrenes; C030984:pyrene; D008628:Mercury
keywords: fluorescent probes; in vivo imaging; mercury; molecular recognition; sensors