title: Lack of association between single nucleotide polymorphism rs10818488 in TRAF1/C5 region and rheumatoid arthritis in iranian population.
abstract: The association of rs10818488 SNP located in TRAF1/C5 region with Rheumatoid Arthritis (RA), has been picked up by genome-wide association studies. Independent studies in different populations revealed inconsistent results. The aim of this study was to investigate the possible association of this SNP with RA in Iranian population. A total of 362 cases and 422 healthy controls were recruited in this study. Genomic DNA was extracted from whole blood and the genotyping was performed by PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism). A set of genotypes was confirmed by sequencing. Genotype and allele frequencies were compared between the case and control groups. Analysis indicated a higher frequency of A allele in cases, although the difference was not statistically significant (Chi-square=2.8, p=0.09). Comparison of genotype frequencies, revealed higher frequencies of AA and AG genotypes in case group but statistically the difference was not significant (Chi-square=2.72, p=0.25). These findings suggest that the rs0818488 in TRAF1/C5 region is not associated with rheumatoid arthritis in Iranian population.
authors: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. ahmadlou@razi.tums.ac.ir.
authors: Somayeh
authors: S
authors: Ahmadlou
authors: Mohsen
authors: M
authors: Akhiani
authors: Ahmad
authors: A
authors: Salimzadeh
authors: Mohammad
authors: M
authors: Keramatipour
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012213:Rheumatic Fever / Q000453:epidemiology / Q000235:genetics*; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics*
chemical_list: D047990:TNF Receptor-Associated Factor 1