title: Role of matrix metalloproteinases and their inhibitor in the development of early pulmonary fibrosis in mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus.
abstract: High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2.
authors: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Vector State Research Center of Virology and Biotechnology, Novosibirsk Region, Koltsovo; Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Russia. potapova@soramn.ru.
authors: A G
authors: AG
authors: Anikina
authors: O V
authors: OV
authors: Potapova
authors: V A
authors: VA
authors: Shkurupii
authors: A M
authors: AM
authors: Shestopalov
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000201:enzymology; D053124:Influenza A Virus, H5N1 Subtype; D016676:Macrophages, Alveolar / Q000201:enzymology; D008297:Male; D053505:Matrix Metalloproteinases, Secreted / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000201:enzymology* / Q000821:virology; D012141:Respiratory Tract Infections / Q000201:enzymology* / Q000821:virology; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*
chemical_list: D019716:Tissue Inhibitor of Metalloproteinase-2; D003094:Collagen; D053505:Matrix Metalloproteinases, Secreted