title: Visual map shifts based on whisker-guided cues in the young mouse visual cortex.
abstract: Mice navigate nearby space using their vision and whiskers, and young mice learn to integrate these heterogeneous inputs in perceptual space. We found that cortical responses were depressed in the primary visual cortex of young mice after wearing a monocular prism. This depression was uniformly observed in the primary visual cortex and was eliminated by whisker trimming or lesions in the posterior parietal cortex. Compensatory visual map shifts of responses elicited via the eye that had worn the prism were also observed. As a result, cortical responses elicited via each eye were clearly separated when a visual stimulus was placed in front of the mice. A comparison of response areas before and after prism wearing indicated that the map shifts were produced by depression with spatial eccentricity. Visual map shifts based on whisker-guided cues may serve as a model for investigating the cellular and molecular mechanisms underlying higher sensory integration in the mammalian brain.
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan; Japan Science and Technology Agency, CREST, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076, Japan.
authors: Kohei
authors: K
authors: Yoshitake
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
authors: Hiroaki
authors: H
authors: Tsukano
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
authors: Manavu
authors: M
authors: Tohmi
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
authors: Seiji
authors: S
authors: Komagata
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
authors: Ryuichi
authors: R
authors: Hishida
authors: KOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; Japan Science and Technology Agency, CREST, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076, Japan.
authors: Takeshi
authors: T
authors: Yagi
authors: Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan; Japan Science and Technology Agency, CREST, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address: shibuki@bri.niigata-u.ac.jp.
authors: Katsuei
authors: K
authors: Shibuki
mesh_terms: D000818:Animals; D013181:Cortical Spreading Depression; D003463:Cues; D005074:Evoked Potentials, Visual; D051379:Mice; D008810:Mice, Inbred C57BL; D010775:Photic Stimulation; D014738:Vibrissae / Q000294:innervation* / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields