title: Sepsis in the central nervous system and antioxidant strategies with N-acetylcysteine, vitamins and statins.
abstract: Sepsis is the complex syndrome characterized by an imbalance between proinflammatory and antiinflammatory response to infection. The brain may be affected during the sepsis, and acute and long-term brain dysfunctions have been observed in both animal models and septic patients. Oxidative stress and antioxidant systems may prove the basis underling brain dysfunction in sepsis. The antioxidant therapy may be theoretically achieved by the following strategies: restoring endogenous antioxidants and nutrients and supplementation with exogenous trace elements, vitamins, and nutrients with antioxidant proprieties; or administering drugs that reduce oxidative stress, such as N-acetylcysteine (NAC), vitamins and statins. In the review, we described below the involvement of oxidative stress and antioxidants defenses and potential utility of these strategies and present data regarding their use in sepsis.
authors: Amanda Valnier
authors: AV
authors: Steckert
authors: Adalberto Alves
authors: AA
authors: de Castro
authors: Joao
authors: J
authors: Quevedo
authors: Laboratorio de Neurociências, PPGCS, UNASAU, Universidade do Extremo Sul Catarinense, Criciuma, 88806-000, SC, Brazil. adalba1@hotmail.com.
authors: Felipe
authors: F
authors: Dal-Pizzol
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy* / Q000473:pathology*; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014815:Vitamins; D000111:Acetylcysteine