title: Fabrication of highly uniform gel coatings by the conversion of surface-anchored metal-organic frameworks.
abstract: We report the fabrication of 3D, highly porous, covalently bound polymer films of homogeneous thickness. These surface-bound gels combine the advantages of metal-organic framework (MOF) materials, namely, the enormous flexibility and the large size of the maximum pore structures and, in particular, the possibility to grow them epitaxially on modified substrates, with those of covalently connected gel materials, namely, the absence of metal ions in the deposited material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stability under biological conditions. The conversion of a SURMOF (surface-mounted MOF) yields a surface-grafted gel. These SURGELs can be loaded with bioactive compounds and applied as bioactive coatings and provide a drug-release platform in in vitro cell culture studies.
authors: Institute of Functional Interfaces (IFG), ‡Soft Matter Synthesis Lab, Institute for Biological Interfaces (IBG), and §Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT) , Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
authors: Manuel
authors: M
authors: Tsotsalas
authors: Jinxuan
authors: J
authors: Liu
authors: Beatrix
authors: B
authors: Tettmann
authors: Sylvain
authors: S
authors: Grosjean
authors: Artak
authors: A
authors: Shahnas
authors: Zhengbang
authors: Z
authors: Wang
authors: Carlos
authors: C
authors: Azucena
authors: Matthew
authors: M
authors: Addicoat
authors: Thomas
authors: T
authors: Heine
authors: Joerg
authors: J
authors: Lahann
authors: Jörg
authors: J
authors: Overhage
authors: Stefan
authors: S
authors: Bräse
authors: Hartmut
authors: H
authors: Gliemann
authors: Christof
authors: C
authors: Wöll
mesh_terms: D001419:Bacteria; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D009942:Organometallic Compounds / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D013499:Surface Properties
chemical_list: D003432:Cross-Linking Reagents; D005782:Gels; D009942:Organometallic Compounds; D003300:Copper