title: Protective effects of meat from lambs on selenium nanoparticle supplemented diet in a mouse model of polycyclic aromatic hydrocarbon-induced immunotoxicity.
abstract: Increased environmental oxidative stress caused primarily by chemicals like polycyclic aromatic hydrocarbons, plays significant role in human diseases. A representative compound, 7,12-dimethylbenz(a)anthracene (DMBA), was used for modeling oxidative damages including the significant decrease of the antioxidant capacity of the blood. Selenium has antioxidant effects but with a narrow therapeutic window. In our current studies to avoid accidental overdose and toxicity selenium was given to meat-producing animals. The standard rodent diet of mice was replaced by meat from lambs either on standard or selenium-enriched diet. Selenium concentration of lamb meat was enhanced three times by nano-selenium administration and an increase in the antioxidant capacity of the blood of mice was measured after the indirect selenium supplementation. Protective effects were also observed against DMBA-induced immunotoxicity. Twice the amount of white blood cells and among them three times more phagocytes survived. Similarly, in their renewal system in bone marrow twice the amount of cells survived and regenerative capacity of granulopoiesis was four times higher than in control DMBA-damaged mice. Our findings suggest functional dietary benefits of lamb meat enriched with selenium by feeding lambs with nanoparticle selenium supplements.
authors: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors: Éva
authors: É
authors: Ungvári
authors: Research Institute of Karcag, Center for Agricultural and Applied Economic Sciences, University of Debrecen, Karcag, Hungary.
authors: István
authors: I
authors: Monori
authors: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors: Attila
authors: A
authors: Megyeri
authors: Department of Internal Medicine, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors: Zoltán
authors: Z
authors: Csiki
authors: Department of Animal Breeding, Center for Agricultural and Applied Economic Sciences University of Debrecen, Debrecen, Hungary.
authors: József
authors: J
authors: Prokisch
authors: Department of Internal Medicine, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors: Attila
authors: A
authors: Sztrik
authors: Institute of Animal Science, Biotechnology and Nature Conservation, Center for Agricultural and Applied Economic Sciences University of Debrecen, Debrecen, Hungary.
authors: András
authors: A
authors: Jávor
authors: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. Electronic address: ibenko@med.unideb.hu.
authors: Ilona
authors: I
authors: Benkő
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects; D007107:Immune System / Q000187:drug effects*; D007958:Leukocyte Count; D008460:Meat; D053768:Metal Nanoparticles; D051379:Mice; D008810:Mice, Inbred C57BL; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D012643:Selenium / Q000737:chemistry*; D012756:Sheep
chemical_list: D000975:Antioxidants; D011084:Polycyclic Aromatic Hydrocarbons; D012643:Selenium
keywords: Immunotoxicity; Nanoparticles; Oxidative stress; Polycyclic aromatic hydrocarbon (PAH); Selenium