title: First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient.
abstract: In vitro maturation (IVM) of immature oocytes retrieved from surgically resected ovaries has been proposed as a method of fertility preservation in ovarian cancer patients undergoing definitive surgery. While there had been several reports of successful derivation of mature oocytes and or embryos, there have been no reports as yet of successful pregnancies. In this case report, we present a pregnancy and live birth from a young patient, with stage IIIC ovarian cancer, who had undergone fertility sparing surgery. The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.
authors: Department of Reproductive Medicine, KKIVF Centre, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore.
authors: E B
authors: EB
authors: Prasath
authors: M L H
authors: ML
authors: Chan
authors: W H W
authors: WH
authors: Wong
authors: C J W
authors: CJ
authors: Lim
authors: M D
authors: MD
authors: Tharmalingam
authors: M
authors: M
authors: Hendricks
authors: S F
authors: SF
authors: Loh
authors: Y N
authors: YN
authors: Chia
mesh_terms: D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D009865:Oocytes / Q000166:cytology*; D010051:Ovarian Neoplasms / Q000150:complications* / Q000628:therapy*; D010052:Ovariectomy; D010053:Ovary / Q000601:surgery; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D055815:Young Adult
keywords: IVF; cryopreservation; fertility preservation; in vitro maturation; ovarian cancer