title: Implementing homo- and heterodecoupling in region-selective HSQMBC experiments.
abstract: An NMR method to enhance the sensitivity and resolution in band-selective long-range heteronuclear correlation spectra is proposed. The excellent in-phase nature of the selHSQMBC experiment allows that homonuclear and/or heteronuclear decoupling can be achieved in the detected dimension of a 2D multiple-bond correlation map, obtaining simplified cross-peaks without their characteristic fine J multiplet structure. The experimental result is a resolution improvement while the highest sensitivity is also achieved. Specifically, it is shown that the (1)H-homodecoupled band-selective (HOBS) HSQMBC experiment represents a new way to measure heteronuclear coupling constants from the simplified in-phase doublets generated along the detected dimension.
authors: Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Catalonia), Spain.
authors: Laura
authors: L
authors: Castañar
authors: Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Catalonia), Spain.
authors: Josep
authors: J
authors: Saurí
authors: Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Catalonia), Spain.
authors: Pau
authors: P
authors: Nolis
authors: Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Catalonia), Spain.
authors: Albert
authors: A
authors: Virgili
authors: Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Catalonia), Spain. Electronic address: teodor.parella@uab.cat.
authors: Teodor
authors: T
authors: Parella
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D016572:Cyclosporine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D001688:Biological Products; D016572:Cyclosporine
keywords: Band-selective HSQMBC; Homonuclear decoupling; Proton–carbon coupling constants; Pure-shift; Resolution enhancement; Sensitivity improvement