title: [A case of metastatic colorectal cancer with hyperammonemic encephalopathy induced by 5-FU in a patient continuously treated with XELOX therapy].
abstract: We report a rare case of a patient with metastatic colorectal cancer who experienced hyperammonemic encephalopathy induced by 5 -fluorouracil(5-FU)and was continuously treated with capecitabine plus oxaliplatin(XELOX)therapy. A 60 years man with anorexia and weight loss was diagnosed with Stage IV rectal cancer, and chemotherapy with XELOX was initiated. When the second course of XELOX therapy was administered, the patient found it difficult to take oral capecitabine. Subsequently, modified FOLFOX6 was administered. Complications such as nausea and vomiting were observed on day 2, with confusion and cognitive disturbances on day 3 . Laboratory examination revealed hyperammonemia, and therefore, branched-chain amino acid solutions were administered as treatment. The patient's symptoms disappeared entirely on day 4. He is currently receiving XELOX therapy.
authors: Dept. of Gastroenterology, Yamagata City Hospital Saiseikan.
authors: Eriko
authors: E
authors: Nakano
authors: Michio
authors: M
authors: Kuroki
authors: Nana
authors: N
authors: Kanno
authors: Yoshifumi
authors: Y
authors: Matsumura
authors: Atsushi
authors: A
authors: Miura
authors: Yoshifumi
authors: Y
authors: Kikuchi
authors: Hidetoshi
authors: H
authors: Hirakawa
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001928:Brain Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D010071:Oxaloacetates; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000597:Amino Acids, Branched-Chain; D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil