title: The genetics of vascular incidents associated with second-generation antipsychotic administration.
abstract: Second-generation antipsychotics (SGA) have been associated with risk of stroke in elderly patients, but the molecular and genetic background under this association has been poorly investigated. The aim of the present study was to prioritize a list of genes with an SGA altered expression in order to characterize the genetic background of the SGA-associated stroke risk. Genes with evidence of an altered expression after SGA treatments in genome-wide investigations, both in animals and men, were identified. The Genetic Association Database (GAD) served to verify which of these genes had a proven positive association with an increased stroke risk, and along with it each evidence was tested and recorded. Seven hundred and forty five genes had evidence of a change of their expression profile after SGA administration in various studies. Nine out of them have also been significantly related to an increased strokes risk. We identified and described nine genes as potential candidates for future genetic studies aimed at identifying the genetic background of the SGA-related stroke risk. Further, we identify the molecular pathways in which these genes operate in order to provide a molecular framework to understand on which basis SGA may enhance the risk for stroke.
authors: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy.
authors: Enrico
authors: E
authors: Cocchi
authors: Antonio
authors: A
authors: Drago
authors: Diana
authors: D
authors: de Ronchi
authors: Alessandro
authors: A
authors: Serretti
mesh_terms: D000368:Aged; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects*; D030541:Databases, Genetic; D005786:Gene Expression Regulation / Q000187:drug effects*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000139:chemically induced* / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents