title: Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams.
abstract: A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates diverse, sp(3)-rich mono- and bicyclic acyl sultams in a highly scalable manner. Modular pairing of stereochemically rich building blocks allows quick access to all possible isomers. Extension to include one-pot, sequential 3-, 4-, and 5-multicomponent protocols is also discussed.
authors: Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States , and The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034 Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
authors: Naeem
authors: N
authors: Asad
authors: Thiwanka B
authors: TB
authors: Samarakoon
authors: Qin
authors: Q
authors: Zang
authors: Joanna K
authors: JK
authors: Loh
authors: Salim
authors: S
authors: Javed
authors: Paul R
authors: PR
authors: Hanson
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001643:Bridged Bicyclo Compounds; D013449:Sulfonamides