title: Body fat distribution and metabolic consequences - Examination opportunities in dogs.
abstract: The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals' metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types.
authors: Szent István University Department and Clinic of Obstetrics and Animal Reproduction, Faculty of Veterinary Science István u. 2 Budapest H-1078 Hungary.
authors: Linda
authors: L
authors: Müller
authors: Szent István University Department and Clinic of Obstetrics and Animal Reproduction, Faculty of Veterinary Science István u. 2 Budapest H-1078 Hungary.
authors: Eszter
authors: E
authors: Kollár
authors: National Frédéric Joliot-Curie Institute of Radiobiology and Radiohygiene Budapest Hungary.
authors: Lajos
authors: L
authors: Balogh
authors: National Frédéric Joliot-Curie Institute of Radiobiology and Radiohygiene Budapest Hungary.
authors: Zita
authors: Z
authors: Pöstényi
authors: University of Debrecen Department of Nuclear Medicine, Faculty of Medicine Debrecen Hungary.
authors: Teréz
authors: T
authors: Márián
authors: University of Debrecen Department of Nuclear Medicine, Faculty of Medicine Debrecen Hungary.
authors: Ildikó
authors: I
authors: Garai
authors: University of Debrecen Department of Nuclear Medicine, Faculty of Medicine Debrecen Hungary.
authors: László
authors: L
authors: Balkay
authors: University of Debrecen Department of Nuclear Medicine, Faculty of Medicine Debrecen Hungary.
authors: György
authors: G
authors: Trencsényi
authors: Szent István University Department and Clinic of Obstetrics and Animal Reproduction, Faculty of Veterinary Science István u. 2 Budapest H-1078 Hungary.
authors: Julianna
authors: J
authors: Thuróczy
keywords: Leptin; abdominal fat; computed tomography; insulin resistance