title: Oxygen regulates molecular mechanisms of cancer progression and metastasis.
abstract: Oxygen is the basic molecule which supports life and it truly is "god's gift to life." Despite its immense importance, research on "oxygen biology" has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word "hypoxia." Scientists have focused on hypoxia-induced transcriptomics and molecular-cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.
authors: Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, Munich, 80636, Germany.
authors: Kartik
authors: K
authors: Gupta
authors: Esha
authors: E
authors: Madan
authors: Muzzammil
authors: M
authors: Sayyid
authors: Hugo
authors: H
authors: Arias-Pulido
authors: Eduardo
authors: E
authors: Moreno
authors: Periannan
authors: P
authors: Kuppusamy
authors: Rajan
authors: R
authors: Gogna
mesh_terms: D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000860:Hypoxia; D008957:Models, Genetic; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen