title: Effects of composition of biocomposite materials implanted into hole defects of the metaphysis on the reparative regeneration and mineralization of bone tissue.
abstract: We carried out a comparative analysis of morphological pattern and element composition of regenerated bone tissue forming in the metaphysis defects after substitution of these defects with calcium phosphate substance containing low-molecular non-collagen bone proteins with various affinities to ion exchangers. We have found that regenerated tissue in the defects grew from the edges to the center and its element composition depended on the maturity of newly formed bone tissue. Implantation material containing non-collagen bone proteins with various affinities to ion exchangers induced no significant changes in the content of analyzed elements of bone tissue around the defect. The content of analyzed elements in the areas distant from the defect area did not change during the experiment.
authors: Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health and Social Development of the Russian Federation, Kurgan, Russia. e-v-osipova@mail.ru.
authors: S N
authors: SN
authors: Luneva
authors: I A
authors: IA
authors: Talashova
authors: E V
authors: EV
authors: Osipova
authors: A N
authors: AN
authors: Nakoskin
authors: A A
authors: AA
authors: Emanov
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D001846:Bone Development; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006811:Humerus / Q000254:growth & development / Q000601:surgery*; D008297:Male; D013977:Tibia / Q000254:growth & development / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C020243:calcium phosphate