title: Modification of collagen formation by mesenchymal stem cells isolated from human adipose tissue in culture and after autotransplantation for abdominal hernia plasty.
abstract: Mesenchymal stem cells from the adipose tissue of patients with postoperative hernias produce excessive amounts of collagen III, which shifts the balance between type III and type I collagens. The proposed technique of pretransplantation preparation allows in vitro stimulation collagen formation processes with predominant activation of collagen I synthesis and normalization of proportion between different collagen types. Abdominal wall repair with polypropylene surgical mesh in combination with autotransplantation of mesenchymal stem cells reduced the collagen III to collagen I ratio due to activation of collagen I synthesis and suppression of collagen III production, which had a positive effect on the structure of in vivo formed connective tissue.
authors: Faculty of Military Medicine, Belarusian State Medical University; Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus. bogdan-5@mail.ru.
authors: V G
authors: VG
authors: Bogdan
authors: M M
authors: MM
authors: Zafranskaya
authors: Yu M
authors: YM
authors: Gain
authors: Yu E
authors: YE
authors: Demidchik
authors: S S
authors: SS
authors: Bagatka
authors: G I
authors: GI
authors: Ivanchik
mesh_terms: D052436:Adipose Tissue, White / Q000473:pathology; D064592:Autografts; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism*; D024061:Collagen Type III / Q000378:metabolism*; D003131:Combined Modality Therapy; D046449:Hernia, Abdominal / Q000378:metabolism / Q000628:therapy*; D059685:Herniorrhaphy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III