title: In Vivo response to compression of 35 breast lesions observed with a two-dimensional locally regularized strain estimation method.
abstract: The objective of this study was to assess the in vivo performance of our 2-D locally regularized strain estimation method with 35 breast lesions, mainly cysts, fibroadenomas and carcinomas. The specific 2-D deformation model used, as well as the method's adaptability, led to an algorithm that is able to track tissue motion from radiofrequency ultrasound images acquired in clinical conditions. Particular attention was paid to strain estimation reliability, implying analysis of the mean normalized correlation coefficient maps. For all lesions examined, the results indicated that strain image interpretation, as well as its comparison with B-mode data, should take into account the information provided by the mean normalized correlation coefficient map. Different trends were observed in the tissue response to compression. In particular, carcinomas appeared larger in strain images than in B-mode images, resulting in a mean strain/B-mode lesion area ratio of 2.59 ± 1.36. In comparison, the same ratio was assessed as 1.04 ± 0.26 for fibroadenomas. These results are in agreement with those of previous studies, and confirm the interest of a more thorough consideration of size difference as one parameter discriminating between malignant and benign lesions.
authors: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, France. Electronic address: elisabeth.brusseau@creatis.insa-lyon.fr.
authors: Elisabeth
authors: E
authors: Brusseau
authors: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, France.
authors: Valérie
authors: V
authors: Detti
authors: Hospices Civils de Lyon, Service de Radiologie, Hôpital de la Croix-Rousse, Lyon, France.
authors: Agnès
authors: A
authors: Coulon
authors: Hospices Civils de Lyon, Service de Radiologie, Hôpital de la Croix-Rousse, Lyon, France.
authors: Emmanuèle
authors: E
authors: Maissiat
authors: Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Lyon, France; Université Lyon 1, Equipe d'Accueil 4129, France; Centre Mémoire de Ressources et de Recherche (CMRR), Hôpital des Charpennes, Lyon, France.
authors: Nawele
authors: N
authors: Boublay
authors: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, France; Hospices Civils de Lyon, Service de Radiologie, Hôpital de la Croix-Rousse, Lyon, France.
authors: Yves
authors: Y
authors: Berthezène
authors: Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, UK.
authors: Jérémie
authors: J
authors: Fromageau
authors: Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, UK.
authors: Nigel
authors: N
authors: Bush
authors: Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, UK.
authors: Jeffrey
authors: J
authors: Bamber
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D019245:Compressive Strength; D003198:Computer Simulation; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006244:Hardness; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D010173:Palpation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength; D016217:Ultrasonography, Mammary / Q000379:methods*
keywords: Breast cancer; Correlation coefficient; Strain estimation; Ultrasound elastography