title: Electrochemical studies for the determination of quetiapine fumarate and olanzapine antipsychotic drugs.
abstract: OBJECTIVE
  Cyclic voltammetry and differential pulse voltammetry were used to explore the diffusion behavior of two antipsychotic drugs at a glassy carbon electrode. A well-defined oxidation peak was obtained in Britton-Robinson (BR) buffer (pH 2.0). The response was evaluated as a function of some variables such as the scan rate, and pH.
  
  
  METHODS
  A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of the cited drugs Olanzapine (OLZ) and Quetiapine fumarate (QUT).
  
  
  RESULTS
  A linear calibration was obtained from 3 × 10(-8) M to 4 × 10(-6) M and 2 × 10(-8) M to 5 × 10(-6) M, with R. S. D. were 1.6 % and 1.2 % for OLZ and QUT, respectively. The limit of detection (LOD) was 1 × 10(-8) M, while the limit of quantification (LOQ) was 3 × 10(-8) M.
  
  
  CONCLUSIONS
  The method was applied to the determination of investigated drugs in urine and serum samples and dosage forms.
authors: National Organization for Drug Control and Research (NODCAR), Pyramid Ave., P. O. B 29 Cairo, Egypt.
authors: Manal A
authors: MA
authors: El-Shal
keywords: Olanzapine; Pharmaceuticals; Quetiapine fumarate; Urine; Voltammetry