title: Long-term potentiation by activation of group I metabotropic glutamate receptors at excitatory synapses in the spinal trigeminal subnucleus oralis.
abstract: In this study, I examined if activation of group I metabotropic glutamate receptors (mGluRs; mGluR1 and 5) induces long-term potentiation (LTP) at excitatory synapses in the ascending pathway from the spinal trigeminal subnuclei caudalis (Vc) to oralis (Vo), in which group I mGluRs are strongly expressed. As a result, the activation of group I mGluRs produced an initial short-lasting depression and subsequently a delayed type of long-term potentiation (LTP) of excitatory synaptic transmission. Analyses of paired pulse ratio and coefficient of variation indicated that the initial short-lasting depression was induced presynaptically, whereas LTP was expressed postsynaptically. In addition, the short-lasting depression and LTP were mostly mediated by mGluR1, and only partially by mGluR5 and the N-methyl-d-aspartate receptor. Thus, this study suggests that group I mGluRs play an important role in the expression of LTP in the Vc-to-Vo pathway.
authors: Department of Oral Physiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 188-1 Samduk-2-ga, Chung-gu, Daegu 700-412, Republic of Korea. Electronic address: dyoun@knu.ac.kr.
authors: Dong-Ho
authors: DH
authors: Youn
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials; D005260:Female; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D008297:Male; D009434:Neural Pathways; D018408:Patch-Clamp Techniques; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000378:metabolism; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D014279:Trigeminal Nucleus, Spinal / Q000187:drug effects* / Q000502:physiology
chemical_list: D018094:Receptors, Metabotropic Glutamate
keywords: Group I mGluR; LTP; Oralis; Spinal trigeminal nucleus