title: Respiratory motion correction in dynamic MRI using robust data decomposition registration - application to DCE-MRI.
abstract: Motion correction in Dynamic Contrast Enhanced (DCE-) MRI is challenging because rapid intensity changes can compromise common (intensity based) registration algorithms. In this study we introduce a novel registration technique based on robust principal component analysis (RPCA) to decompose a given time-series into a low rank and a sparse component. This allows robust separation of motion components that can be registered, from intensity variations that are left unchanged. This Robust Data Decomposition Registration (RDDR) is demonstrated on both simulated and a wide range of clinical data. Robustness to different types of motion and breathing choices during acquisition is demonstrated for a variety of imaged organs including liver, small bowel and prostate. The analysis of clinically relevant regions of interest showed both a decrease of error (15-62% reduction following registration) in tissue time-intensity curves and improved areas under the curve (AUC60) at early enhancement.
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK. Electronic address: valentin.hamy.09@ucl.ac.uk.
authors: Valentin
authors: V
authors: Hamy
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Nikolaos
authors: N
authors: Dikaios
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Shonit
authors: S
authors: Punwani
authors: Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT London, UK.
authors: Andrew
authors: A
authors: Melbourne
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Arash
authors: A
authors: Latifoltojar
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Jesica
authors: J
authors: Makanyanga
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Manil
authors: M
authors: Chouhan
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Emma
authors: E
authors: Helbren
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Alex
authors: A
authors: Menys
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: Stuart
authors: S
authors: Taylor
authors: Centre for Medical Imaging, University College London, 250 Euston Road, NW1 2PG London, UK.
authors: David
authors: D
authors: Atkinson
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007410:Intestinal Diseases / Q000175:diagnosis; D007421:Intestine, Small; D008107:Liver Diseases / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009068:Movement; D025341:Principal Component Analysis; D011469:Prostatic Diseases / Q000175:diagnosis; D015203:Reproducibility of Results; D012119:Respiration; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: Dynamic contrast-enhanced MRI; Registration; Respiratory motion correction; Robust principal component analysis