title: A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
authors: Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Masha G
authors: MG
authors: Savelieff
authors: Yuzhong
authors: Y
authors: Liu
authors: Russell R P
authors: RR
authors: Senthamarai
authors: Kyle J
authors: KJ
authors: Korshavn
authors: Hyuck Jin
authors: HJ
authors: Lee
authors: Ayyalusamy
authors: A
authors: Ramamoorthy
authors: Mi Hee
authors: MH
authors: Lim
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D002614:Chelating Agents / Q000378:metabolism; D056831:Coordination Complexes; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D002614:Chelating Agents; D056831:Coordination Complexes; D054852:Small Molecule Libraries; D003300:Copper; D015032:Zinc