title: Sulfadiazine modified CS/HA PEC destined to wound dressing.
abstract: OBJECTIVE
  To present the research results concerning enhanced antimicrobial and release properties of the chitosan derivative with sulfadiazine/hyaluronic acid polyelectrolyte complex (PEC) hydrogel.
  
  
  METHODS
  The PECs have been prepared from chitosan of different molecular weight, sulfadiazine chitosan derivative and sodium hyaluronate. The complex structure was assessed by FT-IR spectroscopic method and swelling capacity was followed by weighing measurements.
  
  
  RESULTS
  It has been establish that chitosan derivative influenced both PEC properties and swelling capacity.
  
  
  CONCLUSIONS
  Incorporation in PEC of the sulfadiazine chitosan is a new way to combine bacteriostatic effect of chitosan with that of sulfadiazine, to control properties, antimicrobial activity in the treatment of the wound.
authors: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi.
authors: Lenuţa
authors: L
authors: Profire
authors: D
authors: D
authors: Pieptu
authors: Raluca Petronela
authors: RP
authors: Dumitriu
authors: Oana
authors: O
authors: Dragostin
authors: Cornelia
authors: C
authors: Vasile
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001458:Bandages; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000379:methods; D004573:Electrolytes / Q000737:chemistry; D006820:Hyaluronic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared / Q000379:methods; D013411:Sulfadiazine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055675:Viscosupplements / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D004573:Electrolytes; D055675:Viscosupplements; D013411:Sulfadiazine; D006820:Hyaluronic Acid; D048271:Chitosan