title: Palm vitamin eprotects bone against dexamethasone-induced osteoporosis in male rats.
abstract: The aim of this study was to determine the effects of palm oil-derived vitamin E on glucocorticoid-induced osteoporosis. Three-month old male Wistar rats were adrenalectomised to remove circulating glucocorticoids. The animals were then administered with Dexamethasone 120 µg/kg body weight/day. Treatment with palm vitamin E 60 mg/kg body weight/day was given simultaneously. The results showed that palm vitamin E prevented the loss in regional and whole body bone mineral density seen in the Dexamethasone treated animals. Palm vitamin E improved femoral length and calcium content in the Dexamethasone treated animals. The results confirmed that palm oil-derived vitamin E was effective in preventing glucocorticoid-induced osteoporosis.
authors: Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Pharmacology, Ja/an Rala Muda Abdul AZIZ 50300 Kuala Lumpur, Malaysia.
authors: S
authors: S
authors: Ima Nirwana
authors: H
authors: H
authors: Fakhrurazi
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000187:drug effects; D003907:Dexamethasone; D005938:Glucocorticoids; D008297:Male; D010024:Osteoporosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014815:Vitamins
chemical_list: D005938:Glucocorticoids; D014815:Vitamins; D003907:Dexamethasone