title: [Localized primary bone lymphoma: about four cases].
abstract: OBJECTIVE
  To study epidemiological, clinical, pathological anatomy and therapeutic results of localized primary bone lymphoma.
  
  
  METHODS
  Between February 1993 and February 2013, four patients were treated for localized primary bone lymphoma in Sfax's hospitals (Tunisia). Treatment was decided regarding to the age of the patient, his performance status, stage of the disease, lactate dehydrogenase (LDH) and socio-economical conditions of the patient. The therapeutic evaluation was done after chemotherapy and after radiotherapy. There was a clinical, biological and radiological follow-up.
  
  
  RESULTS
  The mean age was 59.5 years. The sex-ratio was 3. Bone localizations were clavicula, femur, humerus and mandibula. All patients had stage I large cell B lymphoma. In 3 cases, imaging showed osteolytic lesions with cortical destruction and extension to soft tissues. One patient had a fracture of the humerus. The treatment consisted in chemotherapy followed by radiotherapy. Three patients were alive with complete remission after a mean follow-up of 76 months.
  
  
  CONCLUSIONS
  The treatment of primary bone lymphoma is based on a combination of chemotherapy (with or without anti-CD20) and radiotherapy. The prognosis is excellent when it is localized.
authors: Service de radiothérapie, CHU Habib-Bourguiba, rue Majida-Boulila, 3029 Sfax, Tunisie; Faculté de médecine, université de Sfax, Sfax, Tunisie. Electronic address: ben_salah_hanen@yahoo.fr.
authors: H
authors: H
authors: Ben Salah
authors: Service de radiothérapie, CHU Habib-Bourguiba, rue Majida-Boulila, 3029 Sfax, Tunisie; Faculté de médecine, université de Sfax, Sfax, Tunisie.
authors: N
authors: N
authors: Fourati
authors: Service d'hématologie, CHU Hédi-Chaker, Sfax, Tunisie; Faculté de médecine, université de Sfax, Sfax, Tunisie.
authors: M
authors: M
authors: Elloumi
authors: Faculté de médecine, université de Sfax, Sfax, Tunisie; Service d'anatomopathologie, CHU Habib-Bourguiba, rue Majida-Boulila, 3029 Sfax, Tunisie.
authors: T
authors: T
authors: Boudawara
authors: Faculté de médecine, université de Sfax, Sfax, Tunisie; Service de carcinologie médicale, CHU Habib-Bourguiba, rue Majida-Boulila, 3029 Sfax, Tunisie.
authors: M
authors: M
authors: Frikha
authors: Service de radiothérapie, CHU Habib-Bourguiba, rue Majida-Boulila, 3029 Sfax, Tunisie; Faculté de médecine, université de Sfax, Sfax, Tunisie.
authors: J
authors: J
authors: Daoud
mesh_terms: D000328:Adult; D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D002968:Clavicle / Q000473:pathology; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005266:Femoral Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D006810:Humeral Fractures / Q000209:etiology; D006811:Humerus / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008339:Mandibular Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D011867:Radioisotope Teletherapy; D012074:Remission Induction; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001761:Bleomycin; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D014751:Vindesine; D011241:Prednisone
keywords: Chemotherapy; Chimiothérapie; Lymphomes osseux primitifs; Primary bone lymphomas; Radiotherapy; Radiothérapie; Treatment