title: [Characterisation of tear film dynamics after application of trehalose for treatment of dry eye].
abstract: The implementation of additional modalities for tear film break-up time characterisation expands the application range of the Oculus® Keratograph 5M. The aim of the present study was to evaluate the possibilities for non-invasive break-up time analysis using this device. Furthermore we applied the Oculus® Keratograph 5M to characterise possible modifications of tear break-up time after application of Thealoz® eye drops (Théa Pharma). The device allowed for a precise and solid topographical analysis of tear film dynamics. We could show that at four weeks after treatment, trehalose solution was a better treatment for dry eye compared with saline. These results are in agreement with our previous in vitro findings concerning the protective role of trehalose on desiccation-caused cell death in a corneal epithelial model.
authors: Augenklinik, Universität Rostock.
authors: T
authors: T
authors: Ramoth
authors: M
authors: M
authors: Hovakimyan
authors: R F
authors: RF
authors: Guthoff
authors: O
authors: O
authors: Stachs
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000627:therapeutic use; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013500:Surface Tension; D013666:Tears / Q000737:chemistry* / Q000187:drug effects*; D016896:Treatment Outcome; D014199:Trehalose / Q000737:chemistry / Q000627:therapeutic use*; D014783:Viscosity; D055815:Young Adult
chemical_list: D009883:Ophthalmic Solutions; D014199:Trehalose