title: Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications.
abstract: The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy.
authors: Gastroenterology and Hepatology Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University Medical School, Canberra, ACT, Australia.
authors: K
authors: K
authors: Subramaniam
authors: M
authors: M
authors: Cherian
authors: S
authors: S
authors: Jain
authors: M
authors: M
authors: Latimer
authors: M
authors: M
authors: Corbett
authors: J
authors: J
authors: D'Rozario
authors: P
authors: P
authors: Pavli
mesh_terms: D000328:Adult; D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D015122:Mercaptopurine
keywords: Epstein-Barr virus; immunosuppression; inflammatory bowel disease; lymphoma; lymphoproliferative disorder