title: Comparison of sensitivity and specificity among 15 criteria for chronic inflammatory demyelinating polyneuropathy.
abstract: BACKGROUND
  There have been 15 formal sets of criteria published for the diagnosis of CIDP. No study to date has compared the sensitivity and specificity of all published criteria in the same patient population.
  
  
  METHODS
  We conducted a retrospective chart review of patients with CIDP (n = 56) and controls with diabetic polyneuropathy (n = 37) or amyotrophic lateral sclerosis (n = 39) who were followed in an academic neuromuscular practice. The sensitivity and specificity of each CIDP criterion was calculated, including clinical, laboratory, and electrodiagnostic components.
  
  
  RESULTS
  Sensitivities ranged from 1.8% to 87.5%; the Dyck (87.5%), Neuropathy Association (75%), and European Federation of Neurological Societies (EFNS; 73.2%) criteria ranked highest. Specificities ranged from 65.6% to 100% and, among the 3 most sensitive criteria, the EFNS (90.8%) and Neuropathy Association (82.9%) criteria were most specific.
  
  
  CONCLUSIONS
  In our patient population, the EFNS and Neuropathy Association criteria stand out due to high sensitivity and specificity.
authors: Division of Neurology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
authors: Ari
authors: A
authors: Breiner
authors: Thomas H
authors: TH
authors: Brannagan
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D001706:Biopsy; D015331:Cohort Studies; D004568:Electrodiagnosis; D004576:Electromyography; D055724:Electrophysiological Phenomena; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis; D009460:Neurologic Examination; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: CIDP; diagnostic criteria; neuropathy; sensitivity; specificity