title: Inclusion complexation of isoprenaline and methyl dopa with α- and β-cyclodextrin nanocavities: spectral and theoretical study.
abstract: Inclusion complex formation of isoprenaline (ISOP) and methyldopa (MDOP) with α-CD and β-CD were investigated. Solid inclusion complex nanomaterials were characterized by SEM, TEM, FTIR, DSC, (1)H NMR and XRD methods. Spectral results showed that single emission (monomer) noticed in aqueous solution where as dual emission (excimer) in CD. Both drugs formed 1:2 (CD-drug2) inclusion complexes with CDs. Time-resolved fluorescence studies show that single exponential decay observed in water whereas biexponential decay observed in CD. Nano-sized particles were found in ISOP/CD while vesicles were obtained in MDOP/CD complexes. DSC results revealed that the thermal stability of drugs was improved when it was included in the CD nanocavity. Based on PM3 calculations, the inclusion structure of ISOP/CD and MDOP/CD complexes were proposed. Thermodynamic parameters and binding affinity of complexation of CD were determined by PM3 method.
authors: Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India. Electronic address: drrajendiran@rediffmail.com.
authors: N
authors: N
authors: Rajendiran
authors: Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
authors: J
authors: J
authors: Thulasidhasan
authors: Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
authors: J
authors: J
authors: Saravanan
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D007545:Isoproterenol / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008750:Methyldopa / Q000737:chemistry*; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D001993:Bronchodilator Agents; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D008750:Methyldopa; C031215:betadex; D007545:Isoproterenol
keywords: Cyclodextrin; Inclusion complex; Isoprenaline; Methyl dopa; Molecular modeling; Nanomaterials