title: A simple one-pot 2-stepN-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis ofN-1-quinoxaline-indoles.
abstract: A straightforward procedure for the preparation ofN-quinoxaline-indoles is presented. A base-catalyzed one-pot addition of indoles to a preformed α-iminoketone proceeds on theN-1 indole and the subsequent adduct undergoes an acid-mediated deprotection of an internal amino nucleophile, intramolecular cyclization and final oxidation generatingN-1-quinoxaline-indoles in good yield.
authors: College of Pharmacy, BIO5 Oro Valley, The University of Arizona, Oro Valley, Arizona 85737, United States.
authors: Guillermo
authors: G
authors: Martinez-Ariza
authors: Muhammad
authors: M
authors: Ayaz
authors: Christopher
authors: C
authors: Hulme
keywords: Indole; Multicomponent reaction; Privileged scaffolds; Quinoxaline; α-iminoketone