title: A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide.
abstract: DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst.
authors: Key Laboratory of Applied Surface and Colloid, Chemistry of Ministry of Education, Department of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062 (China).
authors: Xue
authors: X
authors: Jiang
authors: Chao
authors: C
authors: Wang
authors: Yawen
authors: Y
authors: Wei
authors: Dong
authors: D
authors: Xue
authors: Zhaotie
authors: Z
authors: Liu
authors: Jianliang
authors: J
authors: Xiao
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D005561:Formates / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D007553:Isotope Labeling; D008745:Methylation; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D005561:Formates; D009574:Nitro Compounds; C030544:formic acid; D003903:Deuterium; D007501:Iron; D004121:Dimethyl Sulfoxide
keywords: DMSO; amines; deuterium labelling; formic acid; methylation