title: [The salivary factors related to caries and periodontal disease in children and adolescents with diabetes mellitus].
abstract: OBJECTIVE
  To detect the salivary factors related to caries and periodontal disease and to analyze the risk of caries and periodontal disease in children and adolescents with diabetes mellitus.
  
  
  METHODS
  The study comprised 30 children with diabetic mellitus, aged 7-15 years old, and 60 healthy age-and gender-matched children. Caries and periodontal indexes were recorded and saliva related factors were analyzed.
  
  
  RESULTS
  Caries indexes of diabetes children [permanent teeth: decay missing filling tooth (DMFT) M (Q1,Q3) = 0(0, 4), deciduous teeth: decay missing filling tooth (dmft) M (Q1,Q3) = 0(0, 1)] were not significantly different with those of healthy children [DMFT M (Q1,Q3) = 1(0, 3), dmft M (Q1,Q3) = 0(0, 4)], but plaque index (PLI) (1.25 ± 0.33) and bleeding index (BI) (0.74 ± 0.45) of diabetes children were significantly higher than those of healthy children (PLI was 0.93 ± 0.31,BI was 0.34 ± 0.22) (P < 0.001). Salivary pH of diabetes children (7.68 ± 0.36) was significantly higher than that of healthy children (7.30 ± 0.32) (P < 0.05), and salivary acid buffering capacity had no significant difference between the two groups (P > 0.05). Salivary glucose, immunoglobulin sIgA and sIgG were not significantly different between the two groups (P > 0.05).Salivary lysozyme of diabetes children was significantly higher than that of healthy children (P < 0.05). Total protein was significantly lower in diabetes children than in healthy children (P < 0.05). Salivary lactate dehydrogenase had no significant difference between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  Diabetes mellitus can lead to the changes of some salivary factors related to gingivitis in diabetes children. Children and adolescents with diabetes mellitus may have a higher risk of periodontal disease.
authors: Department of Pediatrics, Peking University School and Hospital of Stomatology,Beijing 100081, China.
authors: Meng-xing
authors: MX
authors: Wang
authors: Xin
authors: X
authors: Wang
authors: Zhi
authors: Z
authors: Zhang
authors: Man
authors: M
authors: Qin
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology* / Q000378:metabolism; D003774:Dental Plaque Index; D048909:Diabetes Complications / Q000150:complications*; D005260:Female; D005891:Gingivitis / Q000209:etiology / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D045022:Lactate Dehydrogenases / Q000378:metabolism; D008297:Male; D009113:Muramidase / Q000378:metabolism*; D010510:Periodontal Diseases / Q000209:etiology* / Q000378:metabolism; D010512:Periodontal Index; D011506:Proteins / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*
chemical_list: D007071:Immunoglobulin A, Secretory; D011506:Proteins; D045022:Lactate Dehydrogenases; D009113:Muramidase; D005947:Glucose