title: [Prognostic Value of Preoperative Anaemia and Perioperative Blood Transfusion in Surgical Treatment of Rectal Cancer].
abstract: BACKGROUND
  There is evidence for the prognostic value of perioperative blood transfusion in the surgical treatment of patients with rectal cancer in the current literature. Also preoperative anaemia seems to have an impact on the outcome of these patients. The aim of this study was to evaluate the impact of preoperative anaemia and perioperative blood transfusion in patients with rectal cancer treated in our hospital.
  
  
  METHODS
  208 patients (81 females, 127 males; median age, 67 years) with rectal cancer were included in this retrospective study. All patients received surgical treatment. In 75 % of the patients an anterior rectum resection was performed while 25 % received an abdominoperineal rectum exstirpation. Patients with neoadjuvant treatment were included and statistical analyses were performed.
  
  
  RESULTS
  107 (51.4 %) patients exhibited preoperative anaemia. Patients with neoadjuvant treatment presented with significantly lower preoperative Hb (haemoglobin) values than patients without neoadjuvant treatment (p = 0.022). Patients with preoperative anaemia received significantly more blood transfusions (p = 0.001), had significantly longer hospital stays (p = 0.023) and significantly lower 5-years overall survival (p = 0.005). Blood transfusion was necessary in 82 patients (39.4 %). These patients presented with a significantly higher rate of perioperative complications (p = 0.01) and a lower 5-years overall survival (p = 0.002). In multivariate analyses neither preoperative anaemia nor perioperative transfusion was a significant prognostic factor.
  
  
  CONCLUSIONS
  In our study preoperative anaemia and perioperative blood transfusion seems to have an impact on outcome of surgical treatment of patients with rectal cancer. However, in multivariate analyses neither preoperative anaemia nor perioperative transfusion was a significant prognostic factor.
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: F
authors: F
authors: Kröpil
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: T
authors: T
authors: Nestler
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: M
authors: M
authors: Toeruen
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: G
authors: G
authors: Fluegen
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: S
authors: S
authors: Kraus
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: A
authors: A
authors: Krieg
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: A
authors: A
authors: Rehders
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: D
authors: D
authors: Vallböhmer
authors: Chirurgische Klinik (A), Heinrich-Heine-Universität und Universitätsklinikum Düsseldorf, Deutschland.
authors: W T
authors: WT
authors: Knoefel
mesh_terms: D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000209:etiology* / Q000401:mortality / Q000601:surgery*; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D005260:Female; D005858:Germany; D006801:Humans; D007902:Length of Stay; D008297:Male; D020360:Neoadjuvant Therapy; D019990:Perioperative Care; D011379:Prognosis; D012004:Rectal Neoplasms / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate