title: Vitamin E and antioxidant activity; its role in slow coronary flow.
abstract: OBJECTIVE
  Oxidative stress, which is widely recognised as an important feature of many diseases, can be defined as an increased formation of reactive oxygen species or decreased antioxidant defense. In this study we measured plasma vitamin E levels and total antioxidant activity (AOA) in patients with slow coronary flow (SCF).
  
  
  METHODS
  The plasma vitamin E levels and AOA were measured in 40 patients with angiographically diagnosed SCF. Forty subjects with normal coronary flow (NCF) served as the control group. SCF and NCF were analysed, and blood samples were taken for plasma vitamin E levels and AOA. Plasma vitamin E levels and AOA in patients with SCF were evaluated and compared to those of patients with NCF.
  
  
  RESULTS
  There was no significant difference between the two groups in terms of plasma AOA, lipid profile and C-reactive protein (CRP) levels but there was a significant difference in vitamin E levels between the two groups (p = 0.001).
  
  
  CONCLUSIONS
  Vitamin E levels were found to be lowered in patients with SCF compared to the NCF group. The association between smoking and vitamin E levels is worth further investigating in larger samples.
authors: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors: Veysel Kenan
authors: VK
authors: Celik
authors: Imge Ezgi
authors: IE
authors: Eken
authors: Gürsel
authors: G
authors: Yildiz
authors: Mehmet Birhan
authors: MB
authors: Yilmaz
authors: Ahmet
authors: A
authors: Gurlek
authors: Hüseyin
authors: H
authors: Aydin
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D017023:Coronary Angiography; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids; D014810:Vitamin E; D002097:C-Reactive Protein