title: Immunohistochemical identification of aquaporin 2 in the kidneys of young beef cattle.
abstract: Aquaporin 2 (AQP2) is a small, integral tetrameric plasma membrane protein that is expressed in mammalian kidneys. The specific constitution of this protein and its selective permeability to water means that AQP2 plays an important role in hypertonic urine production. Immunolocalization of AQP2 has been studied in humans, monkeys, sheep, dogs, rabbits, rats, mice and adult cattle. We analyzed the expression of AQP2 in kidneys of 7-month-old Polish-Friesian var. black and white male calves. AQP2 was localized in the principal cells of collecting ducts in medullary rays penetrating the renal cortex and in the collecting ducts of renal medulla. AQP2 was expressed most strongly in the apical plasma membrane, but expression was observed also in the intracellular vesicles and basolateral plasma membrane. Our study provides new information concerning the immunolocalization of AQP2 in calf kidneys.
authors: Department of Physiology, Cytobiology and Proteomics, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology , Doktora Judyma Str. 6, 71-466.
authors: K
authors: K
authors: Michałek
authors: M
authors: M
authors: Laszczyńska
authors: A K
authors: AK
authors: Ciechanowicz
authors: A
authors: A
authors: Herosimczyk
authors: I
authors: I
authors: Rotter
authors: M
authors: M
authors: Oganowska
authors: A
authors: A
authors: Lepczyński
authors: A
authors: A
authors: Dratwa-Chałupnik
mesh_terms: D000818:Animals; D051399:Aquaporin 2 / Q000032:analysis*; D002417:Cattle; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male
chemical_list: D051399:Aquaporin 2
keywords: aquaporin 2; beef; bovine; cattle; immunohistochemistry; kidney