title: Potential therapeutic effects of functionally active compounds isolated from garlic.
abstract: The medicinal properties of functionally active organosulfur compounds such as allin, diallyl disulfide, S-allylmercaptocysteine, and S-trityl-L-cysteine isolated from garlic have received great attention from a large number of investigators who have studied their pharmacological effects for the treatment of various diseases. These organosulfur compounds are able to prevent for development of cancer, cardiovascular, neurological, and liver diseases as well as allergy and arthritis. There have been also many reports on toxicities and pharmacokinetics of these compounds. The aim of this study is to review a variety of experimental and clinical reports, and describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of pharmaceutical actions of functionally active compounds isolated from garlic.
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Hyung-Mun
authors: HM
authors: Yun
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Jung Ok
authors: JO
authors: Ban
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Kyung-Ran
authors: KR
authors: Park
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Chong Kil
authors: CK
authors: Lee
authors: Department of Food Science and Technology, Chungbuk National University, Chungbuk 361-763, Republic of Korea.
authors: Heon-Sang
authors: HS
authors: Jeong
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Sang Bae
authors: SB
authors: Han
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea. Electronic address: jinthong@chungbuk.ac.kr.
authors: Jin Tae
authors: JT
authors: Hong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002491:Central Nervous System Agents / Q000627:therapeutic use; D005737:Garlic; D006801:Humans; D008517:Phytotherapy; D028321:Plant Preparations / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010946:Plants, Medicinal; D013457:Sulfur Compounds / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D028321:Plant Preparations; D013457:Sulfur Compounds
keywords: Allergy; Arthritis; Cancer; Cardiovascular disorders; Garlic; Liver diseases; Neurological diseases; Organosulfur compounds