title: Effectiveness of the immunochemical fecal test (FIT) for detection of advanced adenomas in colorectal carcinoma screening in an asymptomatic population.
abstract: OBJECTIVE
  The aim of the study was to evaluate the benefit of the immunochemical fecal blood test (FIT) for detection of advanced adenomas.
  
  
  METHODS
  We have conducted a screening study on a average-risk cohort of subjects, aged 50 -74 years. We used a rapid quantitative FIT to perform the screening. Colonoscopy was recommended in all participants with positive FIT. We assessed the participation rate and analyzed advanced adenomas detected in the screening examinations.
  
  
  RESULTS
  Our study enrolled 1111 asymptomatic participants. Immunochemical test results were positive in 72 subjects (6.5%). Colonoscopy was performed by 50/72 (69.4%) subjects. The detection rate for advanced adenomas was 2.2%. A total number of 28 advanced adenomas were detected in 24 subjects, meaning 1.2 advanced adenoma/subject. Analyzing the 3 characteristics of advanced adenomas, we observed in our study that 25/28 adenomas (89.3%) had sizes > or = 10 mm, 11/28 adenomas (39.3%) were tubulovillous/villous and 19/28 adenomas (67.9%) had high dysplasia. The majority of advanced adenomas were found in the left colon as compared to the right colon: 71.4% vs. 28.6%. p = 0.0008.
  
  
  CONCLUSIONS
  In our study was obtained a 2.2% detection rate for advanced adenomas, most of them (71.4%) being located in the left colon. The dominant feature of advanced adenomas detected was the size > or = 10 mm (89.3% of cases).
authors: University of Medicine and Pharmacy "Victor Babel" - Timişoara.
authors: B
authors: B
authors: Miuţescu
authors: I
authors: I
authors: Sporea
authors: Alina
authors: A
authors: Popescu
authors: Simona
authors: S
authors: Bota
authors: Dana
authors: D
authors: Iovănescu
authors: Amelia
authors: A
authors: Burlea
authors: Liana
authors: L
authors: Mos
authors: Mădălina
authors: M
authors: Palaghia
authors: A
authors: A
authors: Vasilescu
authors: E
authors: E
authors: Miuţescu
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000453:epidemiology; D000368:Aged; D015331:Cohort Studies; D044682:Colon, Ascending / Q000473:pathology; D044683:Colon, Descending / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007120:Immunochemistry / Q000379:methods; D015994:Incidence; D007202:Indicators and Reagents; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009780:Occult Blood; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D007202:Indicators and Reagents