title: Abnormal kalirin signaling in neuropsychiatric disorders.
abstract: Changes in dendritic spines structure and function play a critical role in a number of physiological processes, including synaptic transmission and plasticity, and are intimately linked to cognitive function. Alterations in dendritic spine morphogenesis occur in a number of neuropsychiatric disorders and likely underlie the cognitive and behavioral changes associated with these disorders. The neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. Moreover, a series of recent studies have genetically and functionally linked kalirin signaling to several disorders, including schizophrenia and Alzheimer's disease. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target.
authors: Department of Physiology, 303 E. Chicago Avenue, Chicago, IL 60611, USA.
authors: Christine
authors: C
authors: Remmers
authors: Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
authors: Robert A
authors: RA
authors: Sweet
authors: Department of Physiology, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address: p-penzes@northwestern.edu.
authors: Peter
authors: P
authors: Penzes
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020662:Guanine Nucleotide Exchange Factors; C548820:KALRN protein, mouse; C503866:KALRN protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Alzheimer's disease; Genetic; Glutamatergic; Mental disorder; Postmortem; Schizophrenia