title: Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma.
abstract: There is an urgent need to identify environmental risk and protective factors in early life for the prevention of allergy. Our study demonstrates the presence of respiratory allergen from house dust mite, Der p 1, in human breast milk. Der p 1 in milk is immunoreactive, present in similar amounts as dietary egg antigen, and can be found in breast milk from diverse regions of the world. In a mouse model of asthma, oral exposure to Der p through breast milk strongly promotes sensitization rather than protect the progeny as we reported with egg antigen. These data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important implications for the design of studies assessing early oral antigen exposure for allergic disease prevention. The up-to-now unknown worldwide presence of respiratory allergen in maternal milk allows new interpretation and design of environmental control epidemiological studies for allergic disease prevention.
authors: Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors: P
authors: P
authors: Macchiaverni
authors: A
authors: A
authors: Rekima
authors: M
authors: M
authors: Turfkruyer
authors: L
authors: L
authors: Mascarell
authors: S
authors: S
authors: Airouche
authors: P
authors: P
authors: Moingeon
authors: K
authors: K
authors: Adel-Patient
authors: A
authors: A
authors: Condino-Neto
authors: I
authors: I
authors: Annesi-Maesano
authors: S L
authors: SL
authors: Prescott
authors: M K
authors: MK
authors: Tulic
authors: V
authors: V
authors: Verhasselt
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D060829:Arthropod Proteins / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D003546:Cysteine Endopeptidases / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000276:immunology*; D011247:Pregnancy; D039981:Pyroglyphidae / Q000276:immunology*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D060829:Arthropod Proteins; D003546:Cysteine Endopeptidases; C451162:Dermatophagoides pteronyssinus antigen p 1
keywords: allergic sensitization; allergy primary prevention; house dust mite; human breast milk; neonatal oral immune tolerance