title: Plant polyphenols in the treatment of age-associated diseases: revealing the pleiotropic effects of icariin by network analysis.
abstract: Polyphenols are a broad class of compounds. Some are ingested in substantial quantities from nutritional sources, more are produced by medicinal plants, and some of them are taken as drugs. It is becoming clear, that a single polyphenol is impacting several cellular pathways. Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age-related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin, and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.
authors: Division of Immunopathology of the Nervous System, Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.
authors: Jan Kevin
authors: JK
authors: Schluesener
authors: Hermann
authors: H
authors: Schluesener
mesh_terms: D000375:Aging; D009202:Cardiomyopathies / Q000188:drug therapy / Q000235:genetics; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy / Q000235:genetics; D009135:Muscular Diseases / Q000188:drug therapy / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D059808:Polyphenols / Q000494:pharmacology; D056564:Sirtuin 1 / Q000235:genetics
chemical_list: D005419:Flavonoids; D047493:PPAR alpha; D059808:Polyphenols; D019001:Nitric Oxide Synthase; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; C517381:PDE5A protein, human; C447939:SIRT1 protein, human; D056564:Sirtuin 1; C056599:icariin
keywords: Alzheimer; Network; Osteoporosis; Toxicogenomics; Traditional Chinese Medicine (TCM)