title: Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea.
abstract: BACKGROUND
  Maternal prenatal depression is associated with lower offspring birth weight, yet the impact of gestational age on this association remains inadequately understood.
  
  
  OBJECTIVE
  We aimed to investigate the effect of prenatal depression on low birth weight, gestational age, and weight for gestational age at term.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Data were collected from 691 women in their third trimester of pregnancy who went on to give birth to a singleton at term without perinatal complications. One hundred and fifty-two women had a Center for Epidemiologic Studies Depression Scale-10 score ≥10 and were classed as prenatally depressed.
  
  
  METHODS
  Low birth weight (<2500g), gestational age at birth, and birth weight percentile for gestational age.
  
  
  RESULTS
  Offspring of prenatally depressed women were more likely to be low birth weight (Odds ratio [OR] 2.94, 95% confidence interval [CI] 1.14-7.58) than offspring of prenatally non-depressed women, but the association was attenuated (OR 1.66, 95% CI 0.55-5.02) when adjusted for gestational age. Offspring of prenatally depressed women had lower gestational age in weeks (OR for one week increase in gestational age: 0.66, 95% CI 0.47-0.93) than offspring of prenatally non-depressed women. There was no association between prenatal depression and birth weight percentile for gestational age.
  
  
  CONCLUSIONS
  Prenatal depression was not associated with low birth weight at term, but was associated with gestational age, suggesting that association between maternal depression and birth weight may be a reflection of the impact of depression on offspring gestational age.
authors: Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Epidemiology, Columbia University Mailman School of Public Health, NY, USA.
authors: Hyoung Yoon
authors: HY
authors: Chang
authors: Department of Epidemiology, Columbia University Mailman School of Public Health, NY, USA.
authors: Katherine M
authors: KM
authors: Keyes
authors: Department of Rehabilitation, Hanshin University, Gyeonggi-do, Republic of Korea.
authors: Kyung-Sook
authors: KS
authors: Lee
authors: Sewon Infant Child Development Center, Seoul, Republic of Korea.
authors: In Ae
authors: IA
authors: Choi
authors: Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Se Joo
authors: SJ
authors: Kim
authors: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Kyung Won
authors: KW
authors: Kim
authors: Department of Pediatrics, CHA Medical Center, Pochon CHA University College of Medicine, Seoul, Republic of Korea.
authors: Youn Ho
authors: YH
authors: Shin
authors: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Kang Mo
authors: KM
authors: Ahn
authors: Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: sjhong@amc.seoul.kr.
authors: Soo-Jong
authors: SJ
authors: Hong
authors: Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: yjshin@yuhs.ac.
authors: Yee-Jin
authors: YJ
authors: Shin
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D015331:Cohort Studies; D003863:Depression / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007723:Korea; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011446:Prospective Studies
keywords: Birth weight for gestational age; Gestational age; Low birth weight; Prenatal depression; Prospective study; South Korea