title: Respiratory effects of bioaerosols: exposure-response study among salmon-processing workers.
abstract: OBJECTIVE
  The aim of the study was to determine exposure-response relationships in salmon-processing workers.
  
  
  METHODS
  Cross-shift FEV1, acute respiratory symptoms, and exposure to total protein, parvalbumin and endotoxin were main variables measured during one workweek. Exposure-response relationships were analyzed by Generalized Estimation Equations of cross-week data and by multiple regressions of day-to-day data.
  
  
  RESULTS
  Exposure levels were higher in those workers who reported use of water hose. GEE showed negative coefficients for interaction between TP exposure and time (days) on cross-week change of FEV1. Multiple regressions showed significant associations between TP levels and cross-shift change of FEV1 and symptoms (cough, chest tightness) only for Monday shifts.
  
  
  CONCLUSIONS
  A tolerance effect during the course of a workweek is suggested. Use of water hose is a risk process with regard to the liberation of measured components of bioaerosols.
authors: Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, Tromsø, Norway; Department of Occupational and Environmental Medicine, University Hospital North Norway, Tromsø, Norway.
authors: Olga
authors: O
authors: Shiryaeva
authors: Lisbeth
authors: L
authors: Aasmoe
authors: Bjørn
authors: B
authors: Straume
authors: Ann-Helen
authors: AH
authors: Olsen
authors: Arild
authors: A
authors: Øvrum
authors: Eva
authors: E
authors: Kramvik
authors: Merethe
authors: M
authors: Larsen
authors: Anne
authors: A
authors: Renstrøm
authors: Anne-Sophie
authors: AS
authors: Merritt
authors: Kari Kulvik
authors: KK
authors: Heldal
authors: Berit Elisabeth
authors: BE
authors: Bang
mesh_terms: D000328:Adult; D000336:Aerosols; D000818:Animals; D003371:Cough / Q000453:epidemiology*; D004417:Dyspnea / Q000453:epidemiology*; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D005511:Food Handling; D005525:Food-Processing Industry; D005541:Forced Expiratory Volume; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D016272:Occupational Health; D010320:Parvalbumins / Q000633:toxicity*; D010612:Pharyngitis / Q000453:epidemiology; D011506:Proteins / Q000633:toxicity; D012129:Respiratory Function Tests; D012220:Rhinitis / Q000453:epidemiology; D012474:Salmon; D012912:Sneezing
chemical_list: D000336:Aerosols; D004731:Endotoxins; D010320:Parvalbumins; D011506:Proteins
keywords: bioaerosols; exposure-response; lung function; respiratory symptoms; tolerance