title: Intensity based methods for brain MRI longitudinal registration. A study on multiple sclerosis patients.
abstract: Registration is a key step in many automatic brain Magnetic Resonance Imaging (MRI) applications. In this work we focus on longitudinal registration of brain MRI for Multiple Sclerosis (MS) patients. First of all, we analyze the effect that MS lesions have on registration by synthetically eliminating some of the lesions. Our results show how a widely used method for longitudinal registration such as rigid registration is practically unconcerned by the presence of MS lesions while several non-rigid registration methods produce outputs that are significantly different. We then focus on assessing which is the best registration method for longitudinal MRI images of MS patients. In order to analyze the results obtained for all studied criteria, we use both descriptive statistics and statistical inference: one way ANOVA, pairwise t-tests and permutation tests.
authors: Computer Vision and Robotics Group, University of Girona, Campus Montilivi, Ed. P-IV, 17071, Girona, Spain, yago@eia.udg.edu.
authors: Yago
authors: Y
authors: Diez
authors: Arnau
authors: A
authors: Oliver
authors: Mariano
authors: M
authors: Cabezas
authors: Sergi
authors: S
authors: Valverde
authors: Robert
authors: R
authors: Martí
authors: Joan Carles
authors: JC
authors: Vilanova
authors: Lluís
authors: L
authors: Ramió-Torrentà
authors: Alex
authors: A
authors: Rovira
authors: Xavier
authors: X
authors: Lladó
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis*