title: Correlation between brachial artery flow-mediated dilation and endothelial microparticle levels for identifying endothelial dysfunction in children with Kawasaki disease.
abstract: BACKGROUND
  We investigated vascular endothelial dysfunction by sonographic features of flow-mediated dilation (FMD) and circulating endothelial microparticles (EMPs) in Kawasaki disease (KD).
  
  
  METHODS
  Twenty-eight patients with KD were prospectively grouped according to stage of disease: acute, subacute, and convalescent. In addition, 28 healthy children and 28 febrile children were selected as controls. And cases in the convalescent phase were divided into two subgroups: coronary artery lesion (CAL) and no coronary lesion (NCAL). CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs were measured by flow cytometry; FMD was obtained by sonography.
  
  
  RESULTS
  There were significant differences in FMD among the five groups. When compared with healthy controls, there were significantly greater numbers of CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs and a higher proportion of CD62E(+) EMPs in KD patients. The proportions and numbers of CD144(+)/CD42b(-), CD62E(+), and CD105(+) EMPs in KD patients were not statistically different than in febrile controls. There were no significant differences in FMD and EMPs between the CAL and NCAL subgroups. There were significantly negative correlations between the values of FMD and EMPs in the three phases of KD.
  
  
  CONCLUSIONS
  The increased levels of EMPs have significant correlation with decreased values of FMD, both of which may reflect endothelial dysfunction in child KD.
authors: Department of Echocardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Yue-Yue
authors: YY
authors: Ding
authors: Department of Imaging, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Yan
authors: Y
authors: Ren
authors: Institute of Pediatrics, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Xing
authors: X
authors: Feng
authors: Department of Echocardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Qiu-Qin
authors: QQ
authors: Xu
authors: Department of Cardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Ling
authors: L
authors: Sun
authors: Department of Cardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Jian-Min
authors: JM
authors: Zhang
authors: Department of Cardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Ji-Juan
authors: JJ
authors: Dou
authors: Department of Cardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Hai-Tao
authors: HT
authors: Lv
authors: Department of Cardiology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
authors: Wen-Hua
authors: WH
authors: Yan
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001916:Brachial Artery / Q000502:physiology*; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002681:China; D004452:Echocardiography; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis*; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D018709:Statistics, Nonparametric; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology*
chemical_list: D015415:Biomarkers