title: First-in-human trial of nanoelectroablation therapy for basal cell carcinoma: proof of method.
abstract: This nanoelectroablation therapy effectively treats subdermal murine allograft tumors, autochthonous basal cell carcinoma (BCC) tumors in Ptch1+/-K14-Cre-ER p53 fl/fl mice, and UV-induced melanomas in C57/BL6 HGF/SF mice. Here, we described the first human trial of this modality. We treated 10 BCCs on three subjects with 100-1000 electric pulses 100 ns in duration, 30 kV/cm in amplitude, applied at 2 pulses per second. Seven of the 10 treated lesions were completely free of basaloid cells when biopsied and two partially regressed. Two of the 7 exhibited seborrheic keratosis in the absence of basaloid cells. One of the 10 treated lesions recurred by week 10 and histologically had the appearance of a squamous cell carcinoma. No scars were visible at the healed sites of any of the successfully ablated lesions. One hundred pulses were sufficient for complete ablation of BCCs with a single, 1-min nanoelectroablation treatment.
authors: BioElectroMed Corp., Burlingame, CA, USA.
authors: Richard
authors: R
authors: Nuccitelli
authors: Ryan
authors: R
authors: Wood
authors: Mark
authors: M
authors: Kreis
authors: Brian
authors: B
authors: Athos
authors: Joanne
authors: J
authors: Huynh
authors: Kaying
authors: K
authors: Lui
authors: Pamela
authors: P
authors: Nuccitelli
authors: Ervin H
authors: EH
authors: Epstein
mesh_terms: D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D017492:Keratosis, Seborrheic / Q000473:pathology; D008297:Male; D008548:Melanosis / Q000473:pathology; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*
keywords: ablation; apoptosis; basal cell carcinoma; nanoelectroablation; nanosecond pulsed electric field