title: [Cutaneous damage after acute exposure to ionizing radiation: decisive for the prognosis of radiation accident victims].
abstract: The cutaneous radiation syndrome includes all deterministic effects on the skin and visible parts of the mucosa from ionizing radiation. The Intensity and duration of radiation-induced skin symptoms depend on the kind and quality of ionizing radiation. The aim of this study was the investigation of the importance of the time of the development of radiation induced-skin effects on the prognosis of radiation accident victims. Clinical data about radiation accident victims from the database SEARCH were used. 211 cases with good documentation regarding radiation-induced skin effects were selected. From these 211 patients, 166 survived the acute phase of the acute radiation syndrome, while 45 died during the acute phase. Among those patients who did not survive the acute phase, 82.2 % showed their first documented radiation-induced skin symptoms during the first 3 days after radiation exposure. Of those patients whose first documented radiation-induced skin symptoms appeared on or after day four, 94.2 % survived the acute phase. The time to the occurrence of the first radiation-induced skin effects is diagnostically significant. The skin plays an important role in the clinical course of radiation syndromes and in the development of radiation-induced multi-organ failure. In a retrospective data analysis like this, the quality of data might be a limitation.
authors: Institut für Radiobiologie der Bundeswehr in Verbindung mit der Universität Ulm, Neuherbergstr. 11, 80937, München, Deutschland, haralddoerr@bundeswehr.org.
authors: H
authors: H
authors: Dörr
authors: T
authors: T
authors: Baier
authors: V
authors: V
authors: Meineke
mesh_terms: D015984:Causality; D015897:Comorbidity; D016208:Databases, Factual; D004781:Environmental Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009102:Multiple Organ Failure / Q000209:etiology / Q000401:mortality*; D011379:Prognosis; D018788:Radioactive Hazard Release / Q000401:mortality*; D011855:Radiodermatitis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects*; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data*