title: Definitive fractionated re-irradiation for local recurrence following stereotactic body radiotherapy for primary lung cancer.
abstract: OBJECTIVE
  To retrospectively evaluate the efficacy and safety of definitive fractionated re-irradiation for local recurrence following stereotactic body radiotherapy (SBRT) for primary lung cancer.
  
  
  METHODS
  Between April 2003 and December 2011, 398 patients with primary lung tumor underwent SBRT at the Kyushu University Hospital, and 46 out of these developed local recurrence after SBRT. Definitive fractionated re-irradiation was performed for 17 out of the 46 patients. The median dose of re-irradiation was 60 Gy/ 30 fractions. Concurrent chemotherapy was given to four patients.
  
  
  RESULTS
  The median follow-up duration was 12.6 months. At one year post-re-irradiation, local progression-free survival was 33.8%; progression-free survival, 30.9%; cause-specific survival, 79.3%; and overall survival, 74.7%. No severe adverse events were observed during the follow-up.
  
  
  CONCLUSIONS
  Definitive fractionated re-irradiation is thought to be a safe alternative therapy for local recurrence following SBRT, although its efficacy may be not entirely satisfactory.
authors: Department of Comprehensive Clinical Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. yoshitake@radiol.med.kyushu-u.ac.jp.
authors: Tadamasa
authors: T
authors: Yoshitake
authors: Yoshiyuki
authors: Y
authors: Shioyama
authors: Katsumasa
authors: K
authors: Nakamura
authors: Tomonari
authors: T
authors: Sasaki
authors: Saiji
authors: S
authors: Ohga
authors: Makoto
authors: M
authors: Shinoto
authors: Kotaro
authors: K
authors: Terashima
authors: Kaori
authors: K
authors: Asai
authors: Keiji
authors: K
authors: Matsumoto
authors: Hideki
authors: H
authors: Hirata
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D012008:Recurrence; D014057:Tomography, X-Ray Computed
keywords: Lung cancer; fractionation; re-irradiation; stereotactic body radiotherapy