title: Everolimus-eluting stent for the treatment of bare metal in-stent restenosis: clinical and angiographic outcomes at nine-month follow-up of XERES (Xience Evaluation in bare metal stent REStenosis) trial.
abstract: Restenosis is a frequent complication of coronary stent implantation, especially bare metal stent (BMS) implantation. The everolimus-eluting stent (EES) has previously been shown to be efficacious in the treatment of de novo lesions. We performed this study to evaluate clinical, angiographic and IVUS results after EES implantation for the treatment of BMS ISR. XERES was a prospective, multicentre, nationwide study, enrolling 97 consecutive patients with in-stent restenosis (ISR) after BMS implantation across 20 centres in France. Suitable lesions had a reference vessel diameter between 2.5 mm and 4 mm, a length ≤22 mm and a diameter stenosis between 50 and 100%. The primary endpoint was angiographic in-stent late loss (LL) as determined by quantitative coronary angiography (QCA) at nine-month follow-up. QCA was required to be performed in each included patient and IVUS was performed in a subgroup of 27 patients. At nine-month follow-up, the in-stent late loss was 0.35±0.63 mm. The rate of in-stent binary restenosis was 12.22%, including two complete occlusions. The average volume of neointimal hyperplasia was 15.6±9.9 mm3. The in-stent percent volume obstruction was 8.5±5.2%. The in-segment percent area and diameter obstruction were 32±17% and 27±11%, respectively. Two initial malappositions were persistent and two other patients had late acquired stent malapposition. The cumulative incidence of major adverse cardiac events (MACE) was 10.1%. EES for the treatment of bare metal in-stent restenosis seemed safe and efficacious.
authors: Cardiology B, Cardiovascular and Metabolic Pole, Rangueil Hospital, Toulouse, France.
authors: Didier
authors: D
authors: Carrié
authors: Nicolas
authors: N
authors: Delarche
authors: Christophe
authors: C
authors: Piot
authors: Jacques
authors: J
authors: Berland
authors: Nicolas
authors: N
authors: Menneveau
authors: Laurent
authors: L
authors: Bonello
authors: Antoine
authors: A
authors: Py
authors: Emmanuel
authors: E
authors: Teiger
authors: Laurent
authors: L
authors: Leborgne
authors: Gilles
authors: G
authors: Bayet
authors: Olivier
authors: O
authors: Wittenberg
authors: François
authors: F
authors: Schiele
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000628:therapy*; D054855:Drug-Eluting Stents; D000068338:Everolimus; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D058426:Neointima / Q000000981:diagnostic imaging / Q000473:pathology; D011446:Prospective Studies; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000453:epidemiology; D018084:Ultrasonography, Interventional
chemical_list: D000068338:Everolimus; D020123:Sirolimus