title: Associations of cyclooxygenase 2 polymorphic genotypes with bladder cancer risk in Taiwan.
abstract: OBJECTIVE
  Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in southwestern Taiwan. However, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of cyclooxygenase 2 (Cox-2) polymorphic genotypes with Taiwan bladder cancer patients.
  
  
  METHODS
  Six polymorphic variants of Cox-2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same amount of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method.
  
  
  RESULTS
  Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs20417) genotypes were positively associated with bladder cancer risk (p=0.0102). Individuals with the Cox-2 -765GC genotypes were associated with higher prostate cancer risk than those with -765GG.
  
  
  CONCLUSIONS
  Our findings provide evidence that the C allele of Cox-2 promoter G-765C may be associated with the overexpression of COX-2 during bladder cancer development and may be a useful marker for the early detection of bladder cancer.
authors: Terry Fox Cancer Research Lab, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, datian@mail.cmuh.org.tw; artbau2@gmail.com.
authors: Wen-Shin
authors: WS
authors: Chang
authors: Chia-Wen
authors: CW
authors: Tsai
authors: Hong-Xue
authors: HX
authors: Ji
authors: Hsi-Chin
authors: HC
authors: Wu
authors: Yi-Ting
authors: YT
authors: Chang
authors: Chi-Shun
authors: CS
authors: Lien
authors: Wen-Ling
authors: WL
authors: Liao
authors: Wu-Chung
authors: WC
authors: Shen
authors: Chang-Hai
authors: CH
authors: Tsai
authors: Da-Tian
authors: DT
authors: Bau
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D013624:Taiwan; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D017931:DNA Primers; D051546:Cyclooxygenase 2
keywords: Cox-2; bladder cancer; genotype; polymorphism