title: The impact of glucose load on left ventricular mass in peritoneal dialysis patients.
abstract: BACKGROUND
  Cardiovascular (CV) complications are the main cause of morbidity and mortality in peritoneal dialysis (PD) patients. Left ventricular hypertrophy (LVH) is a well-known major CV risk factor.
  
  
  OBJECTIVE
  To evaluate the impact of peritoneal glucose load on left ventricular mass (LVM) in PD patients.
  
  
  METHODS
  In this cross sectional study the glucose load and LVM were evaluated in 43 stable patients on maintenance PD for 24 - 78 months. Glucose load was calculated using a unique peritoneal glucose load index (PGLI) referred to g/kg/day glucose given in the daily PD prescription. LVM index (LVMI) was calculated using the Devereux et al. formula.
  
  
  RESULTS
  The PGLI was positively correlated with HbA1c and LVMI (p < 0.001). Patients with PGLI > 3 g/kg/day had higher HbA1c and LVMI compared to those with PGLI ≤ 3 g/kg/day (p < 0.001).
  
  
  CONCLUSIONS
  Higher PGLI values were associated with worse glycemic control and increased LVMI. Efforts should be made to minimize the PGL. All other risk factors that may contribute to the development of LVH in PD patients should be identified and treated. Additional multicenter, randomized control trials are needed to determine the target objectives of PGLI.
authors: Kamal
authors: K
authors: Hassan
authors: Fadi
authors: F
authors: Hassan
authors: Dunia
authors: D
authors: Hassan
authors: Shadia
authors: S
authors: Hassan
authors: Rabia
authors: R
authors: Edgem
authors: Smadar
authors: S
authors: Moshe
authors: Shadi
authors: S
authors: Hassan
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D015314:Dialysis Solutions / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000009:adverse effects* / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D015314:Dialysis Solutions; D005947:Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human