title: Global and local brain network reorganization in attention-deficit/hyperactivity disorder.
abstract: Brain is a complex network with an anatomical and functional organization. The differences in brain organization of those with attention-deficit/hyperactivity disorder (ADHD) are still not well understood. Here, we study brain organization in ADHD subjects using a complex network derived from resting-state functional magnetic resonance imaging (fMRI) data of ADHD and normal subjects. Our results reveal that the brain networks of ADHD subjects are reorganized compared to those without ADHD in global and local brain functional networks. We find that the ADHD subjects show decreasing brain network integration and increasing brain network segregation. More interestingly, we find similarities of brain topology properties between local and global brain networks. Our finding indicates that cognitive dysfunction in ADHD is probably associated with disrupted global and local brain network topological properties. Our results can help us understand the pathophysiological mechanism of ADHD and serve as a sensitive and specific biomarker of ADHD.
authors: Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China, linpan@mail.xjtu.edu.cn.
authors: Pan
authors: P
authors: Lin
authors: Jubao
authors: J
authors: Sun
authors: Gang
authors: G
authors: Yu
authors: Ying
authors: Y
authors: Wu
authors: Yong
authors: Y
authors: Yang
authors: Meilin
authors: M
authors: Liang
authors: Xin
authors: X
authors: Liu
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest