title: Childhood inflammatory brain diseases: pathogenesis, diagnosis and therapy.
abstract: Inflammatory brain diseases (IBrainDs) are a leading cause of devastating neurological deficits or neuropsychiatric syndromes in previously healthy children. The spectrum is expanding rapidly and new disease entities have been discovered in the last decade. IBrainD can occur as a primary disease or may occur secondary to an underlying cause. This review focuses on the clinical presentation, diagnostic features, pathology and histology characteristics and treatment of the primary childhood IBrainDs.
authors: Division of Rheumatology, Department of Paediatrics and Institute of Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.Division of Rheumatology, Department of Paediatrics and Institute of Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
authors: Marinka
authors: M
authors: Twilt
authors: Division of Rheumatology, Department of Paediatrics and Institute of Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.Division of Rheumatology, Department of Paediatrics and Institute of Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada. susanne.benseler@albertahealthservices.ca.
authors: Susanne M
authors: SM
authors: Benseler
mesh_terms: D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy
keywords: NMDA receptor encephalitis; Rasmussen encephalitis; childhood primary angiitis of the central nervous system; inflammatory brain disease; multiple sclerosis; neuromyelitis optica; neurosarcoidosis