title: The regulation of the autophagic network and its implications for human disease.
abstract: Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.
authors: 1. Department of Cell Biology; University Medical Center Groningen, University of Groningen; Groningen, The Netherlands. ; 2. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Department of Biochemistry and Molecular Biology; Peking University Health Science Center, Beijing 100191, China;
authors: Jing
authors: J
authors: Yang
authors: Serena
authors: S
authors: Carra
authors: Wei-Guo
authors: WG
authors: Zhu
authors: Harm H
authors: HH
authors: Kampinga
mesh_terms: D001343:Autophagy; D004194:Disease; D006801:Humans; D015398:Signal Transduction
keywords: ATGs; Autophagy; FOXO1; HSF1; Heat Shock Proteins (HSP); Human diseases.; UPR; mTOR