title: Small animal optical diffusion tomography with targeted fluorescence.
abstract: Despite the broad impact in medicine that optics can bring, thus far practical approaches are limited to weak scatter or near-surface monitoring. We show a method that utilizes a laser topography scan and a diffusion equation model to describe the photon transport, together with a multiresolution unstructured grid solution to the nonlinear optimization measurement functional, that overcomes these limitations. We conclude that it is possible to achieve whole body optical imaging with a resolution suitable for finding cancer nodules within an organ during surgery, with the aid of a targeted imaging agent.
authors: Vaibhav
authors: V
authors: Gaind
authors: Hsiao-Rho
authors: HR
authors: Tsai
authors: Kevin J
authors: KJ
authors: Webb
authors: Venkatesh
authors: V
authors: Chelvam
authors: Philip S
authors: PS
authors: Low
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D020342:Finite Element Analysis; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007668:Kidney / Q000473:pathology; D007834:Lasers; D051379:Mice; D009369:Neoplasms / Q000473:pathology; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D017785:Photons; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013499:Surface Properties; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*