title: The Connexin37 gene C1019T polymorphism and risk of coronary artery disease: a meta-analysis.
abstract: OBJECTIVE
  Mounting data have emerged suggesting that the Connexin37 C1019T polymorphism increases susceptibility to coronary artery disease (CAD). However, previous studies yielded conflicting results. In the current study, a comprehensive meta-analysis was performed to investigate whether the C1019T polymorphism is associated with CAD risk.
  
  
  METHODS
  A total of 11 studies examining the C1019T polymorphism and CAD were identified using MEDLINE, Embase, CNKI, Wanfang and CBM, in which 5535 CAD patients and 5626 controls were analyzed. A random-effects model was used to calculate odd ratios and confidence intervals, while addressing between-study heterogeneity. Publication bias was weighed using the Egger's test, Begg-Mazemdar test and funnel plot.
  
  
  RESULTS
  In genetic models with striking heterogeneity, the risk of CAD was not associated with the C1019T polymorphism (allele comparison: p = 0.34, OR = 1.11, 95% CI 0.90-1.36). Stratification by disease endpoints indicated that the 1019T allele was significantly associated with myocardial infarction (MI) (allele comparison: p <0.001, OR = 1.59, 95% CI 1.24-2.03). Further meta-regression analysis indicated that a large proportion of heterogeneity was probably due to the varying proportions of diabetes mellitus (DM) across studies (p = 0.014).
  
  
  CONCLUSIONS
  Our results indicated that the C1019T polymorphism may be a moderate risk factor for MI and that DM was likely a potential source of between-study heterogeneity.
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors: Zhijun
authors: Z
authors: Wu
authors: Department of Pulmonary Diseases, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, PR China.
authors: Yuqing
authors: Y
authors: Lou
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors: Wei
authors: W
authors: Jin
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors: Yan
authors: Y
authors: Liu
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors: Lin
authors: L
authors: Lu
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors: Qiujing
authors: Q
authors: Chen
authors: Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Electronic address: zhangruiyan@263.net.
authors: Ruiyan
authors: R
authors: Zhang
mesh_terms: D016022:Case-Control Studies; D017630:Connexins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D012307:Risk Factors; D000097006:Gap Junction alpha-4 Protein
chemical_list: D017630:Connexins; D000097006:Gap Junction alpha-4 Protein
keywords: Connexin; Coronary artery disease; Myocardial infarction; Polymorphism Meta-analysis