title: Biopolymeric film containing bioactive naphthoquinone (shikonin) in combined therapy of inflammatory destructive lesions in the buccal mucosa.
abstract: Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
authors: Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Far-Eastern State Medical University, the Ministry of Health of the Russian Federation, Khabarovsk, Russia. pathol@soramn.ru.
authors: E B
authors: EB
authors: Zagorodnyaya
authors: G I
authors: GI
authors: Oskol'skii
authors: A Ya
authors: AY
authors: Basharov
authors: E L
authors: EL
authors: Lushnikova
authors: L M
authors: LM
authors: Nepomnyashchikh
authors: A S
authors: AS
authors: Zagorodnii
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001704:Biopolymers / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007972:Leukoplakia, Oral / Q000188:drug therapy*; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009285:Naphthoquinones / Q000627:therapeutic use*; D019226:Oral Ulcer / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001704:Biopolymers; D004365:Drugs, Chinese Herbal; D009285:Naphthoquinones; C016101:shikonin; D008747:Methylcellulose