title: Antibacterial effects of the tellurium compound OTD on E. coli isolates.
abstract: The antibacterial effects of a new organo-tellurium compound [Octa-O-bis-(R,R)-tartarate ditellurane (OTD)] on Escherichia coli isolates as a model are shown. OTD was found to be a bactericidal drug. It exhibits inhibition zones on a protein-rich agar medium but not in a protein-poor medium unless a thiol is added. When applied at the lag phase, OTD inhibits more efficiently than at the log phase. Thiols enhance the efficiency at the log phase. OTD inhibits biofilm formation of E. coli. X-ray microanalysis demonstrated damage caused to the Na⁺/K⁺ pumps and leakage of potassium and phosphorous. Scanning electron microscopy demonstrated an incomplete surface of the bacterial cell wall with a concavity in the center that looks like a hole. Transmission electron microscopy demonstrated severe damage, such as depletion, perforation, and holes in the inner membrane. These results indicate for the first time that the new tellurium compound has antibacterial activities.
authors: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002, Ramat Gan, Israel.
authors: Rina
authors: R
authors: Yalew
authors: Dvora
authors: D
authors: Kenigsbuch-Sredni
authors: Benjamin
authors: B
authors: Sredni
authors: Yeshayahu
authors: Y
authors: Nitzan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009942:Organometallic Compounds / Q000494:pharmacology*; D013644:Tartrates / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D013644:Tartrates; C530751:octa-O-bistartarate ditellurane