title: Two new alkaloids from Portulaca oleracea and their cytotoxic activities.
abstract: Two new alkaloids named (3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone (1) and 1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one (2), together with two known compounds (7'R)-N-feruloyl normetanephrine (3) and N-trans-feruloyl tyramine (4) were isolated from the air-dried aerial parts of Portulaca oleracea L. Their structures and configurations were elucidated by spectroscopic methods including 1D NMR, 2D NMR, and HR-MS techniques. In addition, compounds 1-4 were tested for in vitro cytotoxic activities against human lung (K562 and A549) and breast (MCF-7 and MDA-MB-435) cancer cell lines.
authors: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
authors: Jin-Long
authors: JL
authors: Tian
authors: Xiao
authors: X
authors: Liang
authors: Pin-Yi
authors: PY
authors: Gao
authors: Dan-Qi
authors: DQ
authors: Li
authors: Qian
authors: Q
authors: Sun
authors: Ling-Zhi
authors: LZ
authors: Li
authors: Shao-Jiang
authors: SJ
authors: Song
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020014:K562 Cells; D061986:MCF-7 Cells; D015394:Molecular Structure; D031822:Portulaca / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014227:Triazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C587273:(3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone; C587272:1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011728:Pyridones; D014227:Triazines