title: Cerebral amyloid angiopathy in an aged sooty mangabey (Cercocebus atys).
abstract: A 26-y-old male sooty mangabey (Cercocebus atys) was found at necropsy to have a moderate degree of cerebral amyloid β (Aβ) angiopathy in superficial and parenchymal blood vessels of the brain. Senile (Aβ) plaques were absent, as were neurofibrillary tangles and other signs of neurodegeneration. Affected blood vessels were arterial, capillary, and, less frequently, venous in nature. Histologically, the Aβ40 isoform was more prevalent than was Aβ42. As in humans but unlike in squirrel monkeys, the density of lesions in this mangabey increased along a rostral-to-caudal gradient. Therefore mangabeys appear to conform to the general tendency of nonhuman primates by developing cerebral Aβ angiopathy in the absence of other indices of Alzheimer-type neuropathology.
authors: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Olivia M
authors: OM
authors: D'Angelo
authors: Jeromy
authors: J
authors: Dooyema
authors: Cynthia
authors: C
authors: Courtney
authors: Lary C
authors: LC
authors: Walker
authors: Eric
authors: E
authors: Heuer
mesh_terms: D016229:Amyloid beta-Peptides / Q000502:physiology; D000818:Animals; D001921:Brain / Q000503:physiopathology; D016665:Cercocebus atys; D016657:Cerebral Amyloid Angiopathy / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male
chemical_list: D016229:Amyloid beta-Peptides