title: [Factors associated with treatment adherence for tuberculosis infection].
abstract: OBJECTIVE
  To analyze adherence to treatment of tuberculosis infection and to identify risk factors for its compliance.
  
  
  METHODS
  An observational historical cohort study.
  
  
  METHODS
  Hospital Universitari Sant Joan d'Alacant (Alicante).
  
  
  METHODS
  All patients with a tuberculin skin test (TST) done during tuberculosis contact tracing during 6 years.
  
  
  RESULTS
  We included 764 tuberculosis contacts in the analysis. 59.7% of the 566 patients who completed the contact tracing, had tuberculosis infection (TI). Of the patients with TI, 45.6% had not started treatment for tuberculosis infection (TTBI). Factors associated with not starting TTBI were: age (36-65 years, RR: 5.8; 95% CI: 1.2-27.5, and > 65 years, RR: 11.3; 95% CI: 2.0-64.0), the social relationship with TB case (RR: 2.2; 95% CI 1.2-3.8), and the TST reaction (≥ 15mm; RR: 0.5; 95% CI: 0.3-0.9). The completion rate for TTBI was 80.4% among people who started therapy. The treatment regimen was associated with greater compliance to TTBT (7-9H, RR: 12.7; 95% CI: 1.5-107.3).
  
  
  CONCLUSIONS
  The treatment compliance rate of Tuberculosis infection was high among people who started therapy. Almost a half of the contacts with TI did not start treatment, and associated factors were: age, social relationship, and the TST reaction. The treatment regimen was associated with greater compliance. It is important to know the factors associated with adherence to treatment of TI in each health area, and focus efforts on risk groups; thereby approaching the global control of tuberculosis.
authors: Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d'Alacant, Alicante, España; Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández, Elche, Alicante, España. Electronic address: carmen.gallardo@graduado.umh.es.
authors: Carmen R
authors: CR
authors: Gallardo
authors: Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d'Alacant, Alicante, España; Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández, Elche, Alicante, España.
authors: María Teresa
authors: MT
authors: Gea Velázquez de Castro
authors: Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d'Alacant, Alicante, España; Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández, Elche, Alicante, España.
authors: Juana
authors: J
authors: Requena Puche
authors: Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d'Alacant, Alicante, España; Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández, Elche, Alicante, España.
authors: Juan José
authors: JJ
authors: Miralles Bueno
authors: Sección de Epidemiología, Centro de Salud Pública de Alicante, Alicante, España.
authors: María Vicenta
authors: MV
authors: Rigo Medrano
authors: Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d'Alacant, Alicante, España; Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández, Elche, Alicante, España.
authors: Jesús M
authors: JM
authors: Aranaz Andrés
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000188:drug therapy*; D055815:Young Adult; D016903:Drug Monitoring
keywords: Cumplimiento de la medicación; Infección; Infection; Medication adherence; Tuberculosis