title: Ability of vitamin D to reduce inflammation in adults without acute illness.
abstract: In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. The objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury. Five large cross-sectional studies and two randomized controlled trials are the focus of this review. Associations between 25-hydroxyvitamin D (25OHD) and inflammation markers are significant and inverse in study populations with low 25OHD levels (<21 ng/mL). They are also inverse in adults with relatively high inflammation levels. These associations in the few available randomized controlled vitamin D intervention trials have been null; this may be because they were not examined in populations with sufficiently low levels of 25OHD or high levels of inflammation.
authors: Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
authors: Mayra
authors: M
authors: Zanetti
authors: Susan S
authors: SS
authors: Harris
authors: Bess
authors: B
authors: Dawson-Hughes
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000517:prevention & control*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000502:physiology*
chemical_list: D015415:Biomarkers; D014807:Vitamin D; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; C-reactive protein; inflammation; vitamin D