title: Wnt and Bmp fit germ cells to a T.
abstract: Reporting in Developmental Cell, Aramaki et al. (2013) identify T as a key mediator of primordial germ cell (PGC) specification in the embryo. Deconstruction of how Bmp and Wnt signals regulate the expression and targeting of T to regulatory elements of either mesodermal or PGC genes has implications for differentiation in vitro.
authors: Department of Ob/Gyn and Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.
authors: Andrea V
authors: AV
authors: Cantú
authors: Department of Ob/Gyn and Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA. Electronic address: diana.laird@ucsf.edu.
authors: Diana J
authors: DJ
authors: Laird
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D005326:Fetal Proteins / Q000378:metabolism*; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D020825:T-Box Domain Proteins / Q000378:metabolism*; D000098908:Brachyury Protein
chemical_list: D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D000098908:Brachyury Protein