title: Clinical and translational potential of MRI evaluation in knee osteoarthritis.
abstract: Magnetic resonance imaging (MRI) has become an increasingly important imaging technique in osteoarthritis (OA) research, and is widely used in the ongoing endeavor to understand the pathogenesis of OA and to develop structure and disease-modifying OA drugs. MRI offers semiquantitative, quantitative and compositional evaluation of knee OA, and enables visualization of tissues that are not seen by radiography, including but not limited to cartilage, meniscus, bone marrow lesions, synovitis, and muscles. It is now recognized that contrast-enhanced MRI enables more accurate evaluation of synovitis than MRI without contrast. Because of its ability to visualize multiple pain-related tissue pathology in three dimensions, MRI is the best modality for imaging of OA.
authors: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building 3rd Floor, Boston, MA, 02118, USA, dhayashi@bu.edu.
authors: Daichi
authors: D
authors: Hayashi
authors: Ali
authors: A
authors: Guermazi
authors: C Kent
authors: CK
authors: Kwoh
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology*; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000473:pathology; D020370:Osteoarthritis, Knee / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000473:pathology*