title: Comparison of new technology integrated and nonintegrated arterial filters used in cardiopulmonary bypass surgery: a randomized, prospective, and single blind study.
abstract: BACKGROUND
  Innovative cardiopulmonary bypass (CPB) settings have been developed in order to integrate the concepts of "surface-coating," "blood-filtration," and "miniaturization."
  
  
  OBJECTIVE
  To compare integrated and nonintegrated arterial line filters in terms of peri- and postoperative clinical variables, inflammatory response, and transfusion needs.
  
  
  METHODS
  Thirty-six patients who underwent coronary bypass surgery were randomized into integrated (Group In) and nonintegrated arterial line filter (Group NIn) groups. Arterial blood samples for the assessments of complete hemogram, biochemical screening, interleukin-6, interleukin-2R, and C-reactive protein were analyzed before and after surgery. Need for postoperative dialysis, inotropic therapy and transfusion, in addition to extubation time, total amount of drainage (mL), length of intensive care unit, and hospital stay, and mortality rates was also recorded for each patient.
  
  
  RESULTS
  Prime volume was significantly higher and mean intraoperative hematocrit value was lower in Group NIn, but need for erythrocyte transfusion was significantly higher in Group NIn. C-reactive protein values did not differ significantly except for postoperative second day's results, which were found significantly lower in Group In than in Group NIn.
  
  
  CONCLUSIONS
  Intraoperative hematocrit levels were higher and need for postoperative erythrocyte transfusion was decreased in Group In.
authors: Department of Cardiovascular Surgery, Marmara University Medical Faculty, 34668 Istanbul, Turkey.
authors: Özgür
authors: Ö
authors: Gürsu
authors: Selim
authors: S
authors: Isbir
authors: Koray
authors: K
authors: Ak
authors: Fethullah
authors: F
authors: Gerin
authors: Sinan
authors: S
authors: Arsan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D002318:Cardiovascular Diseases / Q000473:pathology / Q000601:surgery*; D005260:Female; D006400:Hematocrit; D006801:Humans; D007362:Intensive Care Units; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016037:Single-Blind Method; D062666:Vascular Access Devices
chemical_list: D053645:Interleukin-2 Receptor alpha Subunit; D015850:Interleukin-6; D002097:C-Reactive Protein