title: Five new compounds from Rhododendron mariae Hance.
abstract: Five new compounds (-)-(7R,8S,7'R,8'S)-4,9,4',9'-tetrahydroxy-3,3'-dimethoxy-7,7'-epoxylignan 9-O-β-d-xylopyranoside (1), (-)-(7'R,8'S)-5'-methoxyl(dimeric coniferyl acetate) (2), (+)-(1R,2S)-1,2-bis(4-hydroxy-3-methoxyphenyl)-3-acetyl-1,3-propanediol (3), (-)-3-((2R,3R)-2-ethoxy-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl)propan-1-ol (4), and (+)-3-((2S,3S)-2-ethoxy-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl)propan-1-ol (5), together with 12 known compounds, were isolated from an ethanol extract of the dried stems of Rhododendron mariae Hance. Their structures were elucidated by NMR, HR-MS, CD, ORD experiments and chemical methods. Compounds 2, 3, 6, and 17 exhibited significant inhibitory effects on the nitric oxide production in lipopolysaccharide activated C57BL6/J mouse macrophages.
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China.
authors: Qiang
authors: Q
authors: Guo
authors: Yong
authors: Y
authors: Li
authors: Yun-Bao
authors: YB
authors: Liu
authors: Hong-Shun
authors: HS
authors: Gu
authors: Ya-Dan
authors: YD
authors: Wang
authors: Qi
authors: Q
authors: Hou
authors: Shi-Shan
authors: SS
authors: Yu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D018547:Plant Stems / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029793:Rhododendron / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D008070:Lipopolysaccharides; D011409:Propylene Glycols; D009569:Nitric Oxide; C041787:1,3-propanediol