title: Combined liver-kidney transplantation: survey of a single center in Spain.
abstract: BACKGROUND
  Renal dysfunction is a common complication of advanced liver failure and liver transplantation. Since the introduction of the MELD criteria the proportion of patients with advanced chronic kidney disease and need for liver transplantation has increased. One alternative is the combined liver-kidney transplant (CLKT). The aim of this study was to evaluate the outcome of this type of transplant in our center.
  
  
  METHODS
  We retrospectively analyzed all combined simultaneous or sequential transplants from 1989 to 2012. We studied demographic and clinical variables. Survival analysis was performed by Kaplan-Meier method.
  
  
  RESULTS
  In the study period, 1,265 kidney and 1,050 liver transplantations were performed; 34 were CLKT (to 29 adults and 5 children); 13 of these were simultaneous and 12 sequential liver-kidney. We also carried out 4 triple liver-pancreas-kidney transplantations, 3 simultaneous and 1 sequential. The mean age was 44.1 ± 15 years, and 27 were male (93.1%); 9 (37.5%) were diabetic. The main causes of liver disease were viral (n = 11 [41.3%; hepatitis virus B, C, or both] and alcoholism (9 [31%]). The renal disease etiology was unknown in 16 (55.1%), IgA nephropathy in 2 (6.8%), membranoproliferative glomerulonephritis in 2 (6.8%), and calcineurin inhibitor toxicity in 4 (13.6%). Transjugular renal biopsy was performed in 6 sequential transplants. Survival of patients who received a CLKT was excellent: 91%, 51%, and 40%, at 1, 5, and 10 years, respectively. No significant difference was found between sequential and simultaneous transplants (log rank 0.5).
  
  
  CONCLUSIONS
  Our results of CLKT show results similar or superior to those of other series and are an alternative to consider in candidates for liver transplantation with chronic kidney disease. Transjugular biopsy is an alternative to study the etiology of renal disease in patients with hepatic dysfunction before or after liver transplantation.
authors: Nephrology Department, Reina Sofia University Hospital, Córdoba, Spain. Electronic address: crisroha@yahoo.com.
authors: C Rodelo
authors: CR
authors: Haad
authors: A
authors: A
authors: Rodriguez-Benot
authors: S
authors: S
authors: Martinez-Vaquera
authors: M D
authors: MD
authors: Navarro-Cabello
authors: M L
authors: ML
authors: Aguera-Morales
authors: M V Pendon
authors: MV
authors: Ruiz de Mier
authors: J L
authors: JL
authors: Montero-Alvarez
authors: M de la
authors: Mde L
authors: Mata-Garcia
authors: J
authors: J
authors: Briceño-Delgado
authors: P
authors: P
authors: Aljama-Garcia
mesh_terms: D000328:Adult; D001706:Biopsy; D058625:End Stage Liver Disease / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D005260:Female; D019538:Health Care Surveys; D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome