title: Effect of long-term treatment with β-adrenoceptor antagonists on blood lipid composition and survival of rats with heart failure of different severity.
abstract: Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profile of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor antagonists increased the index of plasma atherogenicity, which did not depend on the severity of a pathological process. In mild chronic heart failure, these changes were associated with a decrease in HDL concentration, while in severe chronic heart failure; they were related to a tendency towards a decrease in HDL content and an increase in LDL concentration. The increase in survival rate was associated with true antagonism of the agent to β-adrenoceptors (the absence of intrinsic sympathomimetic activity) and, to a lesser extent, with nonselective blockade of β-adrenoceptors.
authors: Department of Pharmacology, Yaroslavl' State Medical Academy, Yaroslavl', Russia. alekssidorov@ya.ru.
authors: A V
authors: AV
authors: Sidorov
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000818:Animals; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy / Q000401:mortality; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D000319:Adrenergic beta-Antagonists; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011943:Receptors, Adrenergic, beta