title: A text messaging intervention to promote medication adherence for patients with coronary heart disease: a randomized controlled trial.
abstract: OBJECTIVE
  Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM.
  
  
  METHODS
  A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA.
  
  
  RESULTS
  Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (p=0.02), percentage number of doses taken (p=0.01), and percentage of prescribed doses taken on schedule (p=0.01). TM response rates were higher for antiplatelets than statins (p=0.005). Self-reported adherence revealed no significant differences among groups.
  
  
  CONCLUSIONS
  TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses.
  
  
  CONCLUSIONS
  Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence.
authors: San Francisco VA Medical Center, Division of Geriatrics, Palliative and Extended Care, USA. Electronic address: linda.park@ucsf.edu.
authors: Linda G
authors: LG
authors: Park
authors: Department of Physiological Nursing, University of California, San Francisco, USA.
authors: Jill
authors: J
authors: Howie-Esquivel
authors: College of Nursing, University of Kentucky, USA.
authors: Misook L
authors: ML
authors: Chung
authors: Department of Physiological Nursing, University of California, San Francisco, USA.
authors: Kathleen
authors: K
authors: Dracup
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D040421:Cell Phone; D003327:Coronary Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D017060:Patient Satisfaction; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011446:Prospective Studies; D017010:Reminder Systems; D060145:Text Messaging
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors
keywords: Antiplatelets; Coronary heart disease; Medication adherence; Mobile phone; Statins; Text messaging