title: [Waldenström macroglobulinemia].
abstract: Waldenström macroglobulinemia is a rare lymphoproliferative disease of B-cell origin.These tumorous B-cells produce monoclonal IgM type protein. Diagnosis is based on the detection of lymphoplasmacytic invasion of the bone marrow and serum electrophoresis. Clinical symptoms such as anemia, hyperviscosity and neuropathy are the commom consequences of bone marrow infiltration and serum monoclonal IgM protein. Former use of alkylating agents are replaced by purine analogues, rituximab and bortezomib. Additional clinical data have also accumulated regarding autologous and allogenous stem-cell transplantation. The authors present their own clinical experience and give a detailed review of current therapeutic approaches. Orv. Hetil., 154(50), 1970-1974.
authors: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Általános Orvostudományi Kar Belgyógyászati Intézet, Hematológiai Tanszék Debrecen Pf. 20 4012.
authors: Béla
authors: B
authors: Telek
authors: Péter
authors: P
authors: Batár
authors: László
authors: L
authors: Váróczy
authors: Lajos
authors: L
authors: Gergely
authors: László
authors: L
authors: Rejtő
authors: Róbert
authors: R
authors: Szász
authors: Zsófia
authors: Z
authors: Miltényi
authors: Zsófia
authors: Z
authors: Simon
authors: Miklós
authors: M
authors: Udvardy
authors: Arpád
authors: A
authors: Illés
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001402:B-Lymphocytes; D000069286:Bortezomib; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D000069283:Rituximab; D008258:Waldenstrom Macroglobulinemia
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007075:Immunoglobulin M; D000069283:Rituximab; D000069286:Bortezomib
keywords: Waldenström macroglobulinemia; Waldenström-macroglobulinaemia; chemoimmunotherapy; fludarabin; fludarabine; kemoimmunoterápia; lymphoplasmacytic cells; lymphoplasmacytoid sejtek; monoclonal IgM protein; monoklonális IgM protein; rituximab; stem-cell transplantation; őssejt-transzplantáció