title: Genetic variations in COMT and DRD2 modulate attentional bias for affective facial expressions.
abstract: Studies have revealed that catechol-O-methyltransferase (COMT) and dopaminegic receptor2 (DRD2) modulate human attention bias for palatable food or tobacco. However, the existing evidence about the modulations of COMT and DRD2 on attentional bias for facial expressions was still limited. In the study, 650 college students were genotyped with regard to COMT Val158Met and DRD2 TaqI A polymorphisms, and the attentional bias for facial expressions was assessed using the spatial cueing task. The results indicated that COMT Val158Met underpinned the individual difference in attentional bias for negative emotional expressions (P = 0.03) and the Met carriers showed more engagement bias for negative expressions than the Val/Val homozygote. On the contrary, DRD2 TaqIA underpinned the individual difference in attentional bias for positive expressions (P = 0.003) and individuals with TT genotype showed much more engagement bias for positive expressions than the individuals with CC genotype. Moreover, the two genes exerted significant interactions on the engagements for negative and positive expressions (P = 0.046, P = 0.005). These findings suggest that the individual differences in the attentional bias for emotional expressions are partially underpinned by the genetic polymorphisms in COMT and DRD2.
authors: Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China ; Laboratory of Medical Molecular Biology, Henan University of Science and Technology, Luoyang, China ; Institute of Population and Health, College of Life Science, Northwest University, Xi'an, China.
authors: Pingyuan
authors: P
authors: Gong
authors: Guomin
authors: G
authors: Shen
authors: She
authors: S
authors: Li
authors: Guoping
authors: G
authors: Zhang
authors: Hongchao
authors: H
authors: Fang
authors: Lin
authors: L
authors: Lei
authors: Peizhe
authors: P
authors: Zhang
authors: Fuchang
authors: F
authors: Zhang
mesh_terms: D001288:Attention; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D055815:Young Adult
chemical_list: D017448:Receptors, Dopamine D2; D002394:Catechol O-Methyltransferase