title: Radical route for the alkylation of purine nucleosides at C6 via Minisci reaction.
abstract: A highly regioselective Minisci reaction with the decarboxylative alkylation of purine nucleosides under mild conditions was developed. With 5 mol % AgNO3 as a catalyst and (NH4)2S2O8 as an oxidant, a series of purine nucleosides including ribosyl, deoxyribosyl, arabinosyl purine nucleosides worked well with primary, secondary, and tertiary aliphatic carboxylic acids.
authors: School of Environment, Henan Normal University , Xinxiang, Henan Province 453007, China.
authors: Ran
authors: R
authors: Xia
authors: Ming-Sheng
authors: MS
authors: Xie
authors: Hong-Ying
authors: HY
authors: Niu
authors: Gui-Rong
authors: GR
authors: Qu
authors: Hai-Ming
authors: HM
authors: Guo
mesh_terms: D000478:Alkylation; D000645:Ammonium Sulfate / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012835:Silver Nitrate / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D016877:Oxidants; D011684:Purine Nucleosides; C031276:ammonium peroxydisulfate; D012835:Silver Nitrate; D000645:Ammonium Sulfate