title: Successful treatment of histiocytic sarcoma and concurrent HIV infection using a combination of CHOP and antiretroviral therapy.
abstract: Histiocytic sarcoma (HS) is a rare malignancy of soft tissues with an unknown etiology. The CHOP (cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride and prednisolone) regimen is often adopted as first-line chemotherapy; however, its therapeutic efficacy against HS is usually low. We herein first present the case of a patient with HS who was infected with human immunodeficiency virus-1 (HIV) in whom treatment with a combination of CHOP and antiretroviral therapy (ART) was successful. The patient has been in complete remission for 12 months following the discontinuation of chemotherapy under continuous ART. This case report may help to promote further investigation of both HS and HIV-related malignancy.
authors: Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan.
authors: Kosuke
authors: K
authors: Narita
authors: Rintaro
authors: R
authors: Noro
authors: Masahiro
authors: M
authors: Seike
authors: Masaru
authors: M
authors: Matsumoto
authors: Kazue
authors: K
authors: Fujita
authors: Jiro
authors: J
authors: Matsumura
authors: Mikiko
authors: M
authors: Takahashi
authors: Masashi
authors: M
authors: Kawamoto
authors: Akihiko
authors: A
authors: Gemma
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology / Q000821:virology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D015497:HIV-1 / Q000187:drug effects*; D054747:Histiocytic Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone