title: New sinularianin sesquiterpenes from soft coral Sinularia sp.
abstract: Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yonghongliu@scsio.ac.cn.
authors: Bin
authors: B
authors: Yang
authors: Shengrong
authors: S
authors: Liao
authors: Xiuping
authors: X
authors: Lin
authors: Junfeng
authors: J
authors: Wang
authors: Juan
authors: J
authors: Liu
authors: Xuefeng
authors: X
authors: Zhou
authors: Xianwen
authors: X
authors: Yang
authors: Yonghong
authors: Y
authors: Liu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002460:Cell Line; D002681:China; D057809:HEK293 Cells; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D009792:Oceans and Seas; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D016328:NF-kappa B; D012717:Sesquiterpenes