title: Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell.
abstract: Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67 kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention.
authors: School of Life Sciences, Shanghai University, Shanghai, 200444, China.
authors: Hong
authors: H
authors: Li
authors: Zhe
authors: Z
authors: Li
authors: Ya-Ming
authors: YM
authors: Xu
authors: Yue
authors: Y
authors: Wu
authors: Kang-Kang
authors: KK
authors: Yu
authors: Can
authors: C
authors: Zhang
authors: Yong-Hua
authors: YH
authors: Ji
authors: Gang
authors: G
authors: Ding
authors: Fu-Xue
authors: FX
authors: Chen
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism
chemical_list: D016588:Anticarcinogenic Agents; D002392:Catechin; C045651:epigallocatechin gallate; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1