title: Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis.
abstract: Epidemiological investigations have shown that overcoming the risk of cancer is related to the consumption of green vegetables and fruits. Many compounds from different origins, such as terrestrial plants and marine and microbial sources, have been reported to have therapeutic effects of which marine sources are the most important because the diversity of marine life is more varied than other sources. Fucoxanthin is one important compound with a marine origin and belongs to the group of carotenoids; it can be found in marine brown seaweeds, macroalgae, and diatoms, all of which have remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable medicinal potential and promising applications in human health. In this review, we summarize the anticancer effects of fucoxanthin through several different mechanisms including anti-proliferation, induction of apoptosis, cell cycle arrest and anti-angiogenesis, and its possible role in the treatment of cancer.
authors: NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan. nishigaki@se.starcat.ne.jp.
authors: Thamaraiselvan
authors: T
authors: Rengarajan
authors: Permaiyan
authors: P
authors: Rajendran
authors: Natarajan
authors: N
authors: Nandakumar
authors: Maruthaiveeran Periyasamy
authors: MP
authors: Balasubramanian
authors: Ikuo
authors: I
authors: Nishigaki
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D059447:Cell Cycle Checkpoints / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D012624:Seaweed / Q000737:chemistry*; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D016588:Anticarcinogenic Agents; D024341:Xanthophylls; C025164:fucoxanthin