title: Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia.
abstract: OBJECTIVE
  Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents.
  
  
  METHODS
  10 severely obese adolescents underwent either LSG (n=5) or RYGB (n=5). 17 normal weight, healthy, age- and gender-matched adolescents served as a normal weight peer group (NWPG). Pre- and 12 months postoperatively, sUA and relevant metabolic parameters (glucose homeostasis, transaminases, lipids) were compared.
  
  
  RESULTS
  Preoperatively, sUA was significantly elevated in patients with severe obesity compared to NWPG. Twelve months after LSG and RYGB, a significant decrease in sUA, BMI, CVD risk factors, hepatic transaminases, and HOMA-IR was observed. Reduction in SDS-BMI significantly correlated with changes in sUA.
  
  
  CONCLUSIONS
  sUA levels and metabolic comorbidities improved following bariatric surgery in severely obese adolescents. The impact of changes in sUA on long-term clinical complications of childhood obesity deserves further study.
authors: Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Leipzig, Germany; University of Dresden, Department of Health Sciences/Public Health, Dresden, Germany.
authors: Andreas
authors: A
authors: Oberbach
authors: Department of Urology, University of Leipzig, Leipzig, Germany.
authors: Jochen
authors: J
authors: Neuhaus
authors: Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Thomas
authors: T
authors: Inge
authors: Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany.
authors: Katharina
authors: K
authors: Kirsch
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University Leipzig, Leipzig, Germany.
authors: Nadine
authors: N
authors: Schlichting
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University Leipzig, Leipzig, Germany; Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
authors: Susann
authors: S
authors: Blüher
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University Leipzig, Leipzig, Germany.
authors: Yvonne
authors: Y
authors: Kullnick
authors: University of Dresden, Department of Health Sciences/Public Health, Dresden, Germany.
authors: Joachim
authors: J
authors: Kugler
authors: Helmholtz Centre for Environmental Research, Department of Metabolomics, Leipzig, Germany.
authors: Sven
authors: S
authors: Baumann
authors: Department of Pediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria. Electronic address: Holger.till@medunigraz.at.
authors: Holger
authors: H
authors: Till
mesh_terms: D000293:Adolescent; D050110:Bariatric Surgery / Q000379:methods; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D015897:Comorbidity; D005260:Female; D015390:Gastric Bypass; D015391:Gastroplasty; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D010535:Laparoscopy; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications / Q000601:surgery*; D010865:Pilot Projects; D014527:Uric Acid / Q000097:blood*; D015431:Weight Loss; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: ALAT; ASAT; Adolescents; BMI; CVD; FPG; FPI; LSG; Laparoscopic sleeve gastrectomy (LSG); MRM; Morbid obesity; RYGB; Roux-Y gastric bypass (RYGB); Roux-en-Y gastric bypass; TG; Uric acid; alanine aminotransferase; aspartate aminotransferase; body mass index; cardiovascular disease; dBP; diastolic blood pressure; fasting plasma glucose; fasting plasma insulin; laparoscopic sleeve gastrectomy; multiple reaction monitoring; sBP; sUA; serum uric acid; systolic blood pressure; triglycerides; γ-GT; γ-glutamyl transferase, HOMA-IR, homeostasis model assessment-insulin-resistance