title: Olive oil based novel thermo-reversible emulsion hydrogels for controlled delivery applications.
abstract: Gels have been considered as a popular mode of delivering medicament for the treatment of sexually transmitted diseases (STDs) (e.g. human immunodeficiency virus, bacterial vaginosis, epididymitis, human papillomavirus infection and condylomata acuminata etc.). The present study discusses the development of novel olive oil based emulsion hydrogels (EHs) using sorbitan monopalmitate as the structuring agent. The developed EHs may be tried as drug delivery vehicle for the treatment of STDs. The formation of EHs was confirmed by fluorescence and confocal microscopy. FTIR studies suggested intermolecular hydrogen bonding amongst the components of the EHs. X-ray diffraction study suggested the amorphous nature of the EHs. The developed EHs have shown non-Newtonian flow behavior. The EHs were found to be biocompatible. The formulations were able to effectively deliver two model antimicrobial drugs (e.g. ciprofloxacin and metronidazole), commonly used in the treatment of the STDs.
authors: Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela, 769008, Odisha, India, vinay.pharma@gmail.com.
authors: Vinay K
authors: VK
authors: Singh
authors: Sowmya
authors: S
authors: Ramesh
authors: Kunal
authors: K
authors: Pal
authors: Arfat
authors: A
authors: Anis
authors: Dillip K
authors: DK
authors: Pradhan
authors: Krishna
authors: K
authors: Pramanik
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001412:Bacillus subtilis / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004058:Diffusion; D004655:Emulsions; D006601:Hexoses / Q000737:chemistry*; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004655:Emulsions; D006601:Hexoses; D020100:Hydrogels; D000069463:Olive Oil; D010938:Plant Oils; C061705:sorbitan monopalmitate