title: Decreased sialylation of IgA1 O-glycans associated with pneumococcal hemolytic uremic syndrome.
abstract: Hemolytic uremic syndrome (HUS) in children is usually caused by Shiga-like toxin-producing Escherichia coli, but approximately 5% of cases are caused by invasive pneumococcal infection (P-HUS). Reported herein is the case of a 9-month-old HUS patient with pneumococcal meningitis who needed hemodialysis for 12 days. Decreased sialylation was characterized in both transferrin N-glycans and IgA1 O-glycans, analyzed in the acute phase on mass spectrometry, consistent with S. pneumonia-produced sialidases hydrolyzing both α2,3- and α2,6-linked sialic acids. The method will complement the T-antigen activation test and help to understand the molecular pathology related to P-HUS.
authors: Pediatric Department, Sakai Municipal Hospital, Osaka, Japan.
authors: Hisaaki
authors: H
authors: Aoki
authors: Masashi
authors: M
authors: Shiomi
authors: Tae
authors: T
authors: Ikeda
authors: Tsubura
authors: T
authors: Ishii
authors: Nobuhiko
authors: N
authors: Shimizu
authors: Masao
authors: M
authors: Togawa
authors: Nobuhiko
authors: N
authors: Okamoto
authors: Machiko
authors: M
authors: Kadoya
authors: Yoshinao
authors: Y
authors: Wada
mesh_terms: D006463:Hemolytic-Uremic Syndrome / Q000378:metabolism* / Q000382:microbiology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000150:complications* / Q000378:metabolism*; D011134:Polysaccharides / Q000378:metabolism*
chemical_list: D007070:Immunoglobulin A; D011134:Polysaccharides
keywords: O-glycan; desialylation; glycoprotein; hemolytic uremic syndrome; mass spectrometry; neuraminidase; pneumococcal infection