title: Dysarthria plus dysphagia is associated with severe sleep-disordered breathing in patients with acute intracerebral hemorrhage.
abstract: OBJECTIVE
  Sleep-disordered breathing (SDB) is a risk factor for stroke. The frequency of SDB in Japanese patients with acute intracerebral hemorrhage (ICH) was investigated, as well as factors associated with SDB severity.
  
  
  METHODS
  Between April 2010 and April 2013, patients with ICH within 24 h of onset were prospectively enrolled to participate in a sleep study within 7 days of admission. SDB was defined as a respiratory disturbance index (RDI: apnea or hypopnea events per hour) of ≥ 5. Patients were assigned to groups based on RDI values of ≥ 30 (severe SDB) and <30 (absent or not severe SDB). The frequency of SDB and factors associated with its severity were investigated using multivariate logistic regression analysis.
  
  
  RESULTS
  Of 97 patients (55 males; mean age 68.1 years) enrolled in the study, 91 (94%) had SDB. Severe SDB was evident in 29 (30%) patients. Compared with the RDI< 30 group, the RDI ≥ 30 group had a higher frequency of dysarthria plus dysphagia (76% vs. 47%, P = 0.008), larger waist circumference [86 (84-92) vs. 84 (78-88) cm, P = 0.019] and a greater body mass index [23.8 (21.1-26.8) vs. 21.5 (19.4-25.0) kg/m(2), P = 0.046]. Multivariate logistic regression analysis showed that dysarthria plus dysphagia was independently associated with severe SDB (odds ratio 3.4; 95% confidence interval 1.250-9.252, P = 0.017).
  
  
  CONCLUSIONS
  Most Japanese patients with acute ICH had SDB, and dysarthria plus dysphagia was associated with severe SDB.
authors: Department of Stroke Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
authors: K
authors: K
authors: Shibazaki
authors: K
authors: K
authors: Kimura
authors: J
authors: J
authors: Aoki
authors: J
authors: J
authors: Uemura
authors: S
authors: S
authors: Fujii
authors: K
authors: K
authors: Sakai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000503:physiopathology; D003680:Deglutition Disorders / Q000150:complications* / Q000503:physiopathology; D004401:Dysarthria / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000503:physiopathology; D055105:Waist Circumference
keywords: dysarthria; dysphagia; intracerebral hemorrhage; sleep-disordered breathing