title: A field effect transistor biosensor with a γ-pyrone derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference.
abstract: Field effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here a new type of transistor developed for the detection of Fe(3+) ions in which this sensing layer is made of a monolayer of lipids, engineered in such a way that it is not sensitive to pH in the acidic range, therefore making the device perfectly suitable for biomedical diagnosis. Probes are γ-pyrone derivatives that have been grafted to the lipid headgroups. Affinity constants derived for the chelator/Fe(3+) complexation as well as for other ions demonstrate very high sensitivity and specificity towards ferric ions with values as high as 5.10(10) M and a detected concentration as low as 50 fM.
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France; School of Engineering Physics, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: tuyenkstnk46@gmail.com.
authors: Tuyen D
authors: TD
authors: Nguyen
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: labed.abdel@gmail.com.
authors: Abdelfettah
authors: A
authors: Labed
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France.
authors: Racha
authors: R
authors: El Zein
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: lavandier@cinam.univ-mrs.fr.
authors: Sébastien
authors: S
authors: Lavandier
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: bedu@cinam.univ-mrs.fr.
authors: Fréderic
authors: F
authors: Bedu
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: ozerov@cinam.univ-mrs.fr.
authors: Igor
authors: I
authors: Ozerov
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: dallaporta@cinam.univ-mrs.fr.
authors: Hervé
authors: H
authors: Dallaporta
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: raimundo@cinam.univ-mrs.fr.
authors: Jean-Manuel
authors: JM
authors: Raimundo
authors: Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: charrier@cinam.univ-mrs.fr.
authors: Anne M
authors: AM
authors: Charrier
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D002412:Cations / Q000032:analysis; D005290:Ferric Compounds / Q000032:analysis*; D007501:Iron / Q000032:analysis*; D008055:Lipids / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*; D012680:Sensitivity and Specificity; D014173:Transistors, Electronic
chemical_list: D002412:Cations; D005290:Ferric Compounds; D008055:Lipids; D011753:Pyrones; D007501:Iron
keywords: Affinity constant; Biosensor; Chelation; FET; Ferric ions; Lipid monolayer; γ-pyrone