title: Smooth muscle cell phenotypic switching in stroke.
abstract: Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells (SMCs) in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a phenotype that will be either detrimental or beneficial to brain repair. Moreover, SMC can be primarily affected genetically or by toxic metabolic molecules. After stroke, this pathological phenotype has an impact on the incidence, pattern, severity, and outcome of the cerebral ischemic disease. Although little research has been conducted on the pathological role and molecular mechanisms of SMC in cerebrovascular ischemic diseases, some therapeutic targets have already been identified and could be considered for further pharmacological development. We examine these different aspects in this review.
authors: Université Paris Diderot, Sorbonne Paris Cité, Angiogenesis and Translational Research Center, INSERM U965, 75475, Paris, France.
authors: Marine
authors: M
authors: Poittevin
authors: Pierre
authors: P
authors: Lozeron
authors: Rose
authors: R
authors: Hilal
authors: Bernard I
authors: BI
authors: Levy
authors: Tatiana
authors: T
authors: Merkulova-Rainon
authors: Nathalie
authors: N
authors: Kubis
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D020521:Stroke / Q000378:metabolism* / Q000473:pathology; D066253:Vascular Remodeling