title: Technical implications in proximal forearm transplantation.
abstract: The field of vascularized composite allotransplantation has developed for more than a decade. Investigators are defining patient selection criteria, transplant indications, immunologic regimens, and tolerance. The majority of the current reported hand transplantations have been for treatment of distal forearm or hand amputations. In more proximal amputees, the functional outcome of the transplanted arm has some unique variables that require a different surgical approach. We present a single case of bilateral proximal forearm transplantation in effort to describe the unique technical considerations in this complex procedure. The surgical procedure is described in detail. At 19 months, our patient had 4/5 strength of finger and thumb flexors and protective extensor as well as 4/5 wrist flexors and extensors. Our patient had recovery of sensation. Our patient now lives independently and does her lower extremity prosthesis independently using her hands. These results are expected to continue to improve with more time. In hand transplantation, functional results have been very promising. The described approach of forearm transplantation allows the transfer of the entire functional unit, which should optimize the ultimate outcome for these more proximal injuries.
authors: Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA.
authors: Nicholas T
authors: NT
authors: Haddock
authors: Benjamin
authors: B
authors: Chang
authors: David J
authors: DJ
authors: Bozentka
authors: David R
authors: DR
authors: Steinberg
authors: Lawrence Scott
authors: LS
authors: Levin
mesh_terms: D000671:Amputation, Surgical; D001132:Arm / Q000637:transplantation*; D005260:Female; D006801:Humans; D018579:Patient Selection; D020127:Recovery of Function; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome; D063986:Vascularized Composite Allotransplantation / Q000379:methods*