title: Genetic cell ablation.
abstract: Targeted cell ablation has proven to be a valuable approach to study in vivo cell functions during organogenesis, tissue homeostasis, and regeneration. Over the last two decades, various approaches have been developed to refine the control of cell ablation. In this review, we give an overview of the distinct genetic tools available for targeted cell ablation, with a particular emphasis on their respective specificity.
authors: Laboratory of Genetics and Development, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, Québec, Canada.
authors: Damien
authors: D
authors: Grégoire
authors: Marie
authors: M
authors: Kmita
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D004167:Diphtheria Toxin / Q000235:genetics* / Q000378:metabolism; D039621:Eukaryotic Initiation Factor-3 / Q000235:genetics / Q000378:metabolism; D041722:Genes, Transgenic, Suicide / Q000235:genetics*; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D008967:Molecular Biology / Q000379:methods; D038081:Organogenesis / Q000235:genetics*; D012038:Regeneration / Q000235:genetics
chemical_list: D004167:Diphtheria Toxin; D039621:Eukaryotic Initiation Factor-3; C096013:EIF3I protein, human