title: Papillary squamous cell carcinoma of the trachea associated with human papillomavirus-18 infection.
abstract: A 75-year-old man presented with the chief complaints of coughing and dyspnea. Chest computed tomography revealed narrowing of the trachea. A tumor measuring 40×33×15 mm in size that caused -90% reduction in the cross-sectional area of the trachea 4 cm above the carina was cauterized with high-frequency electrocautery via a rigid bronchoscope. A pathological examination revealed papillary squamous cell carcinoma with immunohistochemical p16 overexpression. Multiplex polymerase chain reaction confirmed human papillomavirus type 18 DNA in the tumor. At the 12-month follow-up visit following the administration of radiotherapy, the patient exhibited no local recurrence or distant metastasis.
authors: Division of Thoracic Oncology, Shizuoka Cancer Center, Japan.
authors: Hisao
authors: H
authors: Imai
authors: Toshiaki
authors: T
authors: Takahashi
authors: Tetsuhiko
authors: T
authors: Taira
authors: Madoka
authors: M
authors: Kimura
authors: Yukiko
authors: Y
authors: Nakamura
authors: Hirotsugu
authors: H
authors: Kenmotsu
authors: Tateaki
authors: T
authors: Naito
authors: Reiko
authors: R
authors: Watanabe
authors: Haruyasu
authors: H
authors: Murakami
authors: Yasuhisa
authors: Y
authors: Ohde
authors: Masahiro
authors: M
authors: Endo
authors: Takashi
authors: T
authors: Nakajima
authors: Nobuyuki
authors: N
authors: Yamamoto
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002291:Carcinoma, Papillary / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D014134:Tracheal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000821:virology*
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins