title: Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever.
abstract: We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory- confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.
authors: Department of Clinical Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors: Koksal
authors: K
authors: Deveci
authors: Mehmet Burhan
authors: MB
authors: Oflaz
authors: Enver
authors: E
authors: Sancakdar
authors: Elif Bilge
authors: EB
authors: Uysal
authors: Ahmet Sami
authors: AS
authors: Guven
authors: Ali
authors: A
authors: Kaya
authors: Filiz
authors: F
authors: Alkan
authors: Omer
authors: O
authors: Cevit
mesh_terms: D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000097:blood* / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000473:pathology; D008297:Male; D015539:Platelet Activation / Q000276:immunology; D010976:Platelet Count; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*; D014421:Turkey
chemical_list: D019332:Endothelin-1; D015375:Receptors, Interleukin-2
keywords: Crimean-Congo hemorrhagic fever; endothelin-1; soluble IL-2r