title: Endurance time is the most responsive exercise measurement in idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Although pulmonary rehabilitation (PR) has been reported to improve exercise capacity in patients with idiopathic pulmonary fibrosis, it is unknown which exercise measurement is the most responsive for evaluation of PR efficacy. The purpose of this study was to compare the responsiveness of 5 exercise measurements by evaluating the efficacy of PR in subjects with idiopathic pulmonary fibrosis.
  
  
  METHODS
  We conducted a prospective observational study in which 53 subjects with idiopathic pulmonary fibrosis were enrolled. The PR group underwent a 10-week out-patient PR program. The control group was observed without any additional intervention, including PR. Five exercise measurements (endurance time [ET], peak work rate, peak oxygen consumption [V̇O2 ], 6-min walk distance, and incremental shuttle walk distance) were evaluated at baseline and after 10 weeks. The effect size was used for the assessment of responsiveness.
  
  
  RESULTS
  In each group, 24 subjects completed the 5 measurements at baseline and after 10 weeks. The changes in ET (PR: 181.6%; control: -8.2%), peak V̇O2 (PR: 7.6%; control: -5.4%), peak work rate (PR: 15.1%; control: -5.1%), 6-min walk distance (PR: 6.0%; control: -3.8%), and incremental shuttle walk distance (PR: 9.1%; control: -5.1%) were significantly different between the groups after 10 weeks (P < .05). In the PR group, ET showed the most striking improvement among the 5 measurements (P < .05), and its effect size was as large as 2.96, whereas those of the others were all < 0.5.
  
  
  CONCLUSIONS
  ET is the most responsive exercise measurement for evaluating PR efficacy in patients with idiopathic pulmonary fibrosis.
authors: Department of RehabilitationDivision of Health Science, Graduate School of Health Science, Kio University, Kita-katsurahi-gun, Nara, Japan.School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Shizuoka, Japan.
authors: Shinichi
authors: S
authors: Arizono
authors: Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan. taniguchi@tosei.or.jp.
authors: Hiroyuki
authors: H
authors: Taniguchi
authors: Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
authors: Koji
authors: K
authors: Sakamoto
authors: Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
authors: Yasuhiro
authors: Y
authors: Kondoh
authors: Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
authors: Tomoki
authors: T
authors: Kimura
authors: Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
authors: Kensuke
authors: K
authors: Kataoka
authors: Department of Rehabilitation.
authors: Tomoya
authors: T
authors: Ogawa
authors: Department of Rehabilitation.
authors: Fumiko
authors: F
authors: Watanabe
authors: Department of Respiratory Medicine and Allergy, Kinki University School of Medicine, Osaka-sayama, Osaka, Japan.
authors: Osamu
authors: O
authors: Nishiyama
authors: Department of Pulmonary Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
authors: Koichi
authors: K
authors: Nishimura
authors: Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan.
authors: Ryo
authors: R
authors: Kozu
authors: Division of Health Science, Graduate School of Health Science, Kio University, Kita-katsurahi-gun, Nara, Japan.
authors: Kazuyuki
authors: K
authors: Tabira
mesh_terms: D000368:Aged; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000503:physiopathology* / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D013147:Spirometry; D013997:Time Factors
keywords: endurance time; exercise capacity; idiopathic pulmonary fibrosis; pulmonary rehabilitation; responsiveness