title: FTIR spectroscopic comparison of serum from lung cancer patients and healthy persons.
abstract: The incidence and mortality of lung cancer remains so high that it is very urgent to develop an effective method for early detection of lung cancer. Serum can reflect physiological and pathological changes of human body, so FTIR spectroscopy was used to compare lung cancer patients' and healthy persons' serum in this study. The A1080/A1170 ratio might be potentially useful for distinguishing lung cancer patients' serum from healthy persons' serum. Moreover, the result of curve fitting indicated that the ratios of α-helix/antiparallel β-sheet were lower for lung cancer patients' serum than those for healthy persons' serum. These results indicated that IR spectra of serum might be potentially useful for detecting lung cancer.
authors: School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China.
authors: Xin
authors: X
authors: Wang
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
authors: Xiang
authors: X
authors: Shen
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: sdpmedical@126.com.
authors: Daping
authors: D
authors: Sheng
authors: School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China.
authors: Xianliang
authors: X
authors: Chen
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: xcliu1969@tom.com.
authors: Xingcun
authors: X
authors: Liu
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared
keywords: Curve fitting; FTIR spectroscopy; Healthy persons; Lung cancer; Serum