title: Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia.
abstract: OBJECTIVE
  Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.
  
  
  METHODS
  In this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.
  
  
  RESULTS
  All four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.
  
  
  CONCLUSIONS
  This case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.
authors: Gül
authors: G
authors: Eryılmaz
authors: Department of Psychiatry, Uskudar University, Neuropsychiatry Istanbul Hospital, Alemdag Caddesi Site Yolu No:29, Umraniye, Istanbul, Turkey. gokben.hizlisayar@uskudar.edu.tr.
authors: Gökben
authors: G
authors: Hızlı Sayar
authors: Eylem
authors: E
authors: Ozten
authors: Işıl
authors: I
authors: Gögcegöz Gül
authors: Oğuz
authors: O
authors: Karamustafalıoğlu