title: Relationship between IL1β-511C>T and ILRN VNTR polymorphisms and keratoconus.
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1β (IL1 β) (-511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.
  
  
  METHODS
  A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1β (-511C>T) (rs16944) (polymerase chain reaction-restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.
  
  
  RESULTS
  Genotype and allele distribution for IL1β (-511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).
  
  
  CONCLUSIONS
  Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1β-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.
authors: Departments of *Ophthalmology and †Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.
authors: Melis
authors: M
authors: Palamar
authors: Huseyin
authors: H
authors: Onay
authors: Taha Resid
authors: TR
authors: Ozdemir
authors: Esra
authors: E
authors: Arslan
authors: Sait
authors: S
authors: Egrilmez
authors: Ferda
authors: F
authors: Ozkinay
authors: Ayse
authors: A
authors: Yagci
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007640:Keratoconus / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014421:Turkey; D055815:Young Adult
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta