title: Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.
abstract: The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37%) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications.
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Peng
authors: P
authors: Huang
authors: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA).
authors: Jing
authors: J
authors: Lin
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Wanwan
authors: W
authors: Li
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Pengfei
authors: P
authors: Rong
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Zhe
authors: Z
authors: Wang
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Shouju
authors: S
authors: Wang
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Xiaoping
authors: X
authors: Wang
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Xiaolian
authors: X
authors: Sun
authors: Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, National Institutes of Health (USA).
authors: Maria
authors: M
authors: Aronova
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Gang
authors: G
authors: Niu
authors: Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, National Institutes of Health (USA).
authors: Richard D
authors: RD
authors: Leapman
authors: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA).
authors: Zhihong
authors: Z
authors: Nie
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
authors: Xiaoyuan
authors: X
authors: Chen
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D006046:Gold
keywords: biodegradable block copolymers; gold nanovesicles; photoacoustic imaging; photothermal therapy; plasmonic coupling