title: Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils.
abstract: The risk of developing multiple sclerosis (MS) is associated with increased dietary intake of saturated fatty acids. For many years it has been suspected that this disease might be associated with an imbalance between unsaturated and saturated fatty acids. We determined erythrocyte membrane fatty acids levels in Hot nature dietary intervention with co-supplemented hemp seed and evening primrose oils in multiple sclerosis patients. To determine the erythrocyte membrane fatty acids levels and correlate it with expanded disability status scale (EDSS) at baseline after 6 months intervention in MS patients by gas chromatography, in this double blind, randomized trial, 100 RRMS patients with EDSS<6 were allocated into three groups: "Group A" that received co-supplemented hemp seed and evening primrose oils with advised Hot nature diet. "Group B" received olive oil and "Group C" received the co-supplemented oils. The results showed that the mean follow-up was 180 ± 2.9SD days (N=65, 23 M and 42 F aged 34.25 ± 8.07 years with disease duration of 6.80 ± 4.33 years). There was no significant difference in the study parameters at baseline. After 6 months, EDSS, Immunological parameters and the erythrocyte cell membrane with regard to specific fatty acids showed improvement in the group A and C, whereas there was worsening condition for the group B after the intervention. We concluded that Hot-nature dietary intervention with co-supplemented hemp seed and evening primrose oils caused an increase PUFAs in MS patients and improvement in the erythrocyte membrane fatty acids composition. This could be an indication of restored plasma stores, and a reflection of disease severity reduction.
authors: School of Nutrition and Health, Tabriz University of Medical Sciences, Iran ; Neurosciences Research Center, Tabriz University of Medical Sciences, Iran.
authors: Soheila
authors: S
authors: Rezapour-Firouzi
authors: Seyed Rafie
authors: SR
authors: Arefhosseini
authors: Mehrangiz
authors: M
authors: Ebrahimi-Mamaghani
authors: Mehdi
authors: M
authors: Farhoudi
authors: Behzad
authors: B
authors: Baradaran
authors: Torbati Mohammad
authors: TM
authors: Ali
authors: Fatemeh
authors: F
authors: Zamani
mesh_terms: D000328:Adult; D002188:Cannabis; D002849:Chromatography, Gas; D019587:Dietary Supplements; D004311:Double-Blind Method; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*; D031665:Oenothera biennis; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*; D012639:Seeds; D016896:Treatment Outcome; D017965:gamma-Linolenic Acid / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D005227:Fatty Acids; D008041:Linoleic Acids; D010938:Plant Oils; C028498:evening primrose oil; D017965:gamma-Linolenic Acid
keywords: Cannabis sativa L; Cell membrane fluidity (CMF); Oenothera biennis L; Polyunsaturated fatty acid; expanded disability status scale (EDSS)