title: Changes in Otx2 and parvalbumin immunoreactivity in the superior colliculus in the platelet-derived growth factor receptor-β knockout mice.
abstract: The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR- β ) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR- β -knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR- β KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR- β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. These findings suggest that PDGFR- β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.
authors: System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan ; Department of Anatomy, Histology and Embryology, Shanghai Medical School, Fudan University, Shanghai 200032, China.
authors: Juanjuan
authors: J
authors: Zhao
authors: Susumu
authors: S
authors: Urakawa
authors: Jumpei
authors: J
authors: Matsumoto
authors: Ruixi
authors: R
authors: Li
authors: Yoko
authors: Y
authors: Ishii
authors: Masakiyo
authors: M
authors: Sasahara
authors: Yuwen
authors: Y
authors: Peng
authors: Taketoshi
authors: T
authors: Ono
authors: Hisao
authors: H
authors: Nishijo
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D051857:Otx Transcription Factors / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000172:deficiency* / Q000235:genetics; D012919:Social Behavior; D013477:Superior Colliculi / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014018:Tissue Distribution
chemical_list: D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D010320:Parvalbumins; D020797:Receptor, Platelet-Derived Growth Factor beta