title: [Effects of xenon anesthesia on cerebral blood flow in neurosurgical patients without intracranial hypertension].
abstract: Among anesthetic agents used in neurosurgery xenon appears to be the most advantageous. It preserves arterial blood pressure, assures rapid recovery and neuroprotection. But the data is lacking on xenon effect upon cerebral blood flow under anesthetic conditions. We measured flow velocity in middle cerebral artery in neurosurgical patients without intracranial hypertension during closed circuit xenon anesthesia comparing propofol and xenon effect in the same patients. In our study xenon didn't seem to induce clinically relevant changes in cerebral blood flow and preserved cerebral vascular reactivity thus proving its safety in patients without intracranial hypertension.
authors: A V
authors: AV
authors: Rylova
authors: A Iu
authors: AIu
authors: Beliaev
authors: A Iu
authors: AIu
authors: Lubnin
mesh_terms: D000769:Anesthesia, Inhalation / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D017585:Ultrasonography, Doppler, Transcranial; D014978:Xenon / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018685:Anesthetics, Inhalation; D014978:Xenon