title: Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy.
abstract: BACKGROUND
  Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE).
  
  
  METHODS
  We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-.
  
  
  RESULTS
  A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) were of the e4/-, and 14 (10%) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26% had moderate or severe disabilities. Disability prevalence was 30 and 19% among those with and without the e3/e3 genotype, 25 and 26% among those with and without the e2 allele, and 18 and 29% among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups.
  
  
  CONCLUSIONS
  Disability was not associated with the APOE genotype in this cohort of HIE survivors.
authors: Department of Pediatrics, Duke University, Durham, North Carolina.
authors: C Michael
authors: CM
authors: Cotten
authors: Department of Pediatrics, Duke University, Durham, North Carolina.
authors: Ricki F
authors: RF
authors: Goldstein
authors: Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, North Carolina.
authors: Scott A
authors: SA
authors: McDonald
authors: Department of Pediatrics, Duke University, Durham, North Carolina.
authors: Ronald N
authors: RN
authors: Goldberg
authors: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
authors: Walid A
authors: WA
authors: Salhab
authors: Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama.
authors: Waldemar A
authors: WA
authors: Carlo
authors: Department of Pediatrics, University of Texas Medical School at Houston, Houston, Texas.
authors: Jon E
authors: JE
authors: Tyson
authors: Division of Neonatology, University of California, San Diego, San Diego, California.
authors: Neil N
authors: NN
authors: Finer
authors: Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve, Cleveland, Ohio.
authors: Michele C
authors: MC
authors: Walsh
authors: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
authors: Richard A
authors: RA
authors: Ehrenkranz
authors: Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, Rhode Island.
authors: Abbot R
authors: AR
authors: Laptook
authors: University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: Ronnie
authors: R
authors: Guillet
authors: Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors: Kurt
authors: K
authors: Schibler
authors: Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
authors: Krisa P
authors: KP
authors: Van Meurs
authors: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
authors: Brenda B
authors: BB
authors: Poindexter
authors: Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.
authors: Barbara J
authors: BJ
authors: Stoll
authors: Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors: T Michael
authors: TM
authors: O'Shea
authors: University of Miami Miller School of Medicine, Miami, Florida.
authors: Shahnaz
authors: S
authors: Duara
authors: Social, Statistical, and Environmental Sciences, RTI International, Rockville, Maryland.
authors: Abhik
authors: A
authors: Das
authors: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
authors: Rosemary D
authors: RD
authors: Higgins
authors: Department of Pediatrics, Wayne State University, Detroit, Michigan.
authors: Seetha
authors: S
authors: Shankaran
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D017931:DNA Primers / Q000235:genetics; D005838:Genotype; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000235:genetics* / Q000503:physiopathology*; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence
chemical_list: D001057:Apolipoproteins E; D017931:DNA Primers