title: Hyperthyrotropinemia in relation to endothelial dysfunction in obese adolescents.
abstract: CONCLUSIONS
  
  
  
  BACKGROUND
  It has been shown that isolated elevation of thyroid stimulating hormone (hyperthyrotropinemia) is quite frequent in obese adolescents, but it is not clear whether this condition entails an increased risk related to body mass index (BMI).
  
  
  OBJECTIVE
  The aim of the current study was to investigate the relationship between hyperthyrotropinemia and endothelial dysfunction and other cardiovascular risk factors in obese adolescents.
  
  
  METHODS
  Seventeen obese adolescents with hyperthyrotropinemia (TSH ≥ 4.2 μUI/ml) (group 1), 21 obese adolescents with normal thyroid stimulating hormone (TSH) level (group 2) and 10 age- and sex-matched healthy lean controls were included in the study. Fasting blood glucose (FBG), lipid profile, insulin resistance (HOMA-IR) and thyroid hormones were determined. All participants were subjected to ultrasound recording of brachial artery diameter at rest and after reactive hyperemia (FMD) for assessment of endothelial function.
  
  
  RESULTS
  BMI and free triiodothyronine (fT3) levels were higher in obese adolescents with hyperthyrotropinemia (group 1) than in those with normal TSH (group 2) (p < 0.05), but there were no significant differences between the two groups in other metabolic parameters (lipid profile and HOMA-IR). The FMD was significantly low in obese adolescents (groups 1 and 2) relative to controls (3.4 ± 18% in group 1 and 3.6 ± 2.2% in group 2 vs. 10.4 ± 3.1% in control subjects), but there was no statistical difference between obese adolescents with hyperthyrotropinemia (group 1) and those with normal TSH (group 2). There were positive correlations between TSH and BMI (p = 0.03) and between fT3 and BMI (p = 0.04), but no correlation between TSH and lipid profile, HOMA-IR or FMD.
  
  
  CONCLUSIONS
  Hyperthyrotropinemia is not related to endothelial dysfunction or metabolic risk factors in obese adolescents.
authors: Department of Internal Medicine, Endocrinology Division, Specialized Medical Hospital, Mansoura University, Faculty of Medicine, Mansoura, Egypt. Electronic address:eman.eladawy@yahoo.com.
authors: Eman H
authors: EH
authors: El-Adawy
authors: Department of Pediatric Endocrinology, King Fahad Hofuf Hospital, Al-Ehssa, Saudi Arabia.
authors: Abdul Mohsen N
authors: AM
authors: Almulhim
authors: Department of Clinical Pathology, Alexandria University, Alexandria, Egypt.
authors: Maha
authors: M
authors: Sallam
authors: Department of Radiology, Alexandria University, Alexandria, Egypt.
authors: Mahmoud
authors: M
authors: Agha
authors: Department of Cardiology, Zagazig General Hospital, Zagazig, Egypt.
authors: Mahmoud N
authors: MN
authors: Eldien