title: Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer.
abstract: Combining oncolytic viruses with conventional therapy such as radiation is an innovative option for pancreatic cancer. We demonstrated that combination of GLV-1h151 and radiation yielded a synergistic cytotoxic effect, with the greatest effect achieved in the AsPC-1cell line. Combination treatment significantly increased apoptosis compared with either single treatment or the control group. In mice bearing human pancreatic tumor xenografts, combination treatment resulted in significantly enhanced inhibition of tumor growth. No evidence of toxicity was observed in mice. These results indicate that the combination of GLV-1h151 and radiation has great potential for translation into clinic practice.
authors: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors: M H
authors: MH
authors: Dai
authors: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors: S L
authors: SL
authors: Liu
authors: Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA; Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center, University of California, San Diego, CA 92093, USA.
authors: N G
authors: NG
authors: Chen
authors: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors: T P
authors: TP
authors: Zhang
authors: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors: L
authors: L
authors: You
authors: Department of Radiotherapy, Peking Union Medical College Hospital, Beijing 100730, China.
authors: F
authors: F
authors: Q Zhang
authors: Department of Preclinical Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors: T C
authors: TC
authors: Chou
authors: Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA; Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center, University of California, San Diego, CA 92093, USA; Department of Biochemistry, Rudolf Virchow Center for Experimental Biomedicine, Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.
authors: A A
authors: AA
authors: Szalay
authors: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address: FongY@mskcc.org.
authors: Y
authors: Y
authors: Fong
authors: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address: Zhaoyp8028@gmail.com.
authors: Y P
authors: YP
authors: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000628:therapy* / Q000821:virology; D000818:Animals; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D050130:Oncolytic Virotherapy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000532:radiotherapy / Q000628:therapy* / Q000821:virology; D011897:Random Allocation; D014616:Vaccinia virus / Q000502:physiology*; D023041:Xenograft Model Antitumor Assays
keywords: Pancreatic cancer; Synergism; Virus