title: [The variants of changes in pro- and antioxidative processes in viral hepatitis and the necessity of differential approach in their antioxidative therapy].
abstract: There was investigated the changes in pro- and antioxidative processes in viral hepatitis of different etiology. It was revealed that the mechanisms mentioned above essentially differ from each other and for their treatment, accordingly, different groups of antioxidative drugs should be used. The data obtained indicates the impossibility of "universal" antioxidative therapy. The role of oxidative stress in the mechanisms of different types of hepatitis and unforeseen negative effect of antioxidative therapy requires special caution and attention in selection of mitochondrial respiratory chain stabilizing antioxidants. In hepatitis A, which is characterized by relatively less intensity of peroxidation natural antiradical remedies should be used (e.g. tocopherol). In viral hepatitis B and especially in hepatitis C, it is desirable to use the selenium-containing antioxidants. In hepatitis B, which is characterized by relatively less content of nitric oxide, it is recommended to use the stimulants of NO synthesis.
authors: N V
authors: NV
authors: Kipiani
authors: V A
authors: VA
authors: Kipiani
authors: N S
authors: NS
authors: Pavliashvili
authors: M Sh
authors: MSh
authors: Nomaradze
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004578:Electron Spin Resonance Spectroscopy; D016174:Hepacivirus / Q000187:drug effects* / Q000472:pathogenicity; D006505:Hepatitis / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase