title: Group B Streptococci investigation in pre-term labors.
abstract: BACKGROUND
  Pre-term delivery is still a main cause of perinatal mortality and morbidities. This study was designed to find any association between maternal Group B Streptococcus (GBS) colonization and pre-term delivery.
  
  
  METHODS
  This case-control study was conducted from March 2010 to May 2011 at two referral university hospitals (Al-Zahra and Shaheed Beheshty), Isfahan University of Medical Sciences, Isfahan, Iran. The study sample of pregnant women was composed of a control group of 200 term pregnancy with at least 37 complete weeks, and a case group of another 200 women between 20 to 37 weeks of pregnancy with pre-term labor. Maternal GBS colonization was compared between two groups.
  
  
  RESULTS
  Maternal age (26.03 +/- 4.81 vs. 27.19 +/-5.60, P = 0.07) and gravid (1.75 +/- 0.88 vs. 1.83 +/-1.08, P = 0.52) were similar in case and control groups. Level of education and gestational age were significantly higher in control versus case group (P = 0.01, P = 0.00). History ofantibiotic use during pregnancywas more frequent in case group compared with control group (P = 0.00). There were 59/151 (39.1%) positive vaginal samples in case group compared with 36/178 (20.2%) in control group (P = 0.000). There were 55/151 (36.4%) positive rectal samples in case group versus 30/178 (16.9%) in control group (P = 0.000).
  
  
  CONCLUSIONS
  This study showed that GBS colonization was statistically higher in pre-term labors compared with term deliveries. To understand the mechanism of GBS effect on pregnancy, large observational studies are needed, with clearly defined outcomes, and with prognostic risk factors for pre-term delivery taken into account.
authors: Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Elahe Zarean
authors: EZ
authors: Seyyed
authors: Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Ehsan
authors: E
authors: Toossi
authors: Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Akram
authors: A
authors: Jalalvand
authors: Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mehdi
authors: M
authors: Sajadi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D015169:Colony Count, Microbial; D004522:Educational Status; D005260:Female; D005865:Gestational Age; D006801:Humans; D007492:Iran / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents