title: Changes of protein profile of human urine after long-term orbital flights.
abstract: We analyzed protein profile of urine samples obtained from 7 Russian cosmonauts (age 35-51 years), participants of space flights on the International Space Station lasting for 169-199 days. Gradient chromatography with linear increase of eluent proportion was carried out in a system consisting of an Agilent 1100 chromatograph (Agilent Technologies Inc.) and a hybrid mass-spectrometer LTQ-FT Ultra (Thermo). The obtained results help to understand changes in the human body induced by space flight factors.
authors: State Scientific Center of the Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow; Yu. A. Gagarin Research and Test Cosmonaut Training Center, Zvezdnyi Gorodok, Moscow Region; Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. lpastushkova@mail.ru.
authors: L Kh
authors: LKh
authors: Pastushkova
authors: O A
authors: OA
authors: Valeeva
authors: A S
authors: AS
authors: Kononikhin
authors: E N
authors: EN
authors: Nikolaev
authors: I M
authors: IM
authors: Larina
authors: I V
authors: IV
authors: Dobrokhotov
authors: I A
authors: IA
authors: Popov
authors: V I
authors: VI
authors: Pochuev
authors: K S
authors: KS
authors: Kireev
mesh_terms: D000328:Adult; D018480:Astronauts; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D010455:Peptides / Q000652:urine*; D011506:Proteins / Q000032:analysis*; D040901:Proteomics; D013026:Space Flight; D016482:Urinalysis; D014556:Urine / Q000737:chemistry*; D014893:Weightlessness
chemical_list: D010455:Peptides; D011506:Proteins