title: What do we need to eradicate rubella in the Islamic Republic of Iran?
abstract: To evaluate the need for congenital rubella syndrome prevention in our national health programme we aimed to determine the rate of anti-rubella positivity in umbilical cord blood samples 8 years after measles-rubella mass vaccination in the Islamic Republic of Iran. In a cross-sectional study we tested umbilical cord blood samples for anti-rubella IgG and IgM by ELISA in 154 deliveries at a university hospital in Tehran. Overall 72.7% of umbilical cord blood samples were positive for anti-rubella lgG and 27.3% were negative. All of the samples were negative for anti-rubella IgM. In the samples with a history of mothers' rubella vaccination, only 87.5% were positive for anti-rubella IgG. The results suggest the need for another mass vaccination for rubella in women of child-bearing age and continuation of routine vaccination of infants, plus consideration of obligatory anti-rubella IgG testing before pregnancy in women who were not vaccinated and vaccination of women before marriage.
authors: Department of Obstetrics and Gynaecology, Tehran University of Medical Sciences, Tehran, Islamic Republic of lran.
authors: F
authors: F
authors: Almassinokiani
authors: S
authors: S
authors: Noorbakhsh
authors: M
authors: M
authors: Rezaei
authors: A
authors: A
authors: Almasi
authors: H
authors: H
authors: Akbari
authors: S
authors: S
authors: Asadolla
authors: P
authors: P
authors: Rahimzadeh
authors: M
authors: M
authors: Saberifard
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D003430:Cross-Sectional Studies; D060740:Disease Eradication; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006785:Hospitals, University; D006801:Humans; D017589:Immunization Programs / Q000458:organization & administration; D007492:Iran / Q000453:epidemiology; D012409:Rubella / Q000276:immunology* / Q000517:prevention & control*; D012410:Rubella Syndrome, Congenital / Q000517:prevention & control; D012411:Rubella Vaccine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D012411:Rubella Vaccine; C040901:rubella antibodies