title: Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males.
abstract: The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, cross-over study to evaluate the effects of a 2-h native GLP1 infusion. Plasma proANP concentrations were measured by an automated mid-region-directed proANP immunoassay and N-terminal pro B-type natriuretic peptide (BNP) on Roche Modular E170. Urine was collected for measurements of sodium excretion. Although GLP1 infusion increased the urinary sodium excretion markedly, there were no significant changes in either proANP or proBNP concentrations. When GLP1 infusion was stopped, sodium excretion declined rapidly. As proANP concentration reflects ANP secretion, our data could not confirm the existence of a GLP1-ANP axis in humans. Especially, the natriuretic effects of GLP1 seem unlikely to be mediated exclusively via ANP.
authors: Department of Endocrinology and Internal MedicineAarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus, Denmark Novo Nordisk A/SDK-2880 Bagsvaerd, Denmark NNF center for Basic Metabolic ResearchDepartment of Biomedical Sciences, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark Department of Clinical BiochemistryRigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Department of Clinical Physiology and Molecular ImagingAarhus University Hospital, Aarhus, Denmark Department of Clinical MedicineAarhus University, DK-8000 Aarhus, Denmark.
authors: Jeppe
authors: J
authors: Skov
authors: Jens Juul
authors: JJ
authors: Holst
authors: Jens Peter
authors: JP
authors: Gøtze
authors: Jørgen
authors: J
authors: Frøkiær
authors: Jens Sandahl
authors: JS
authors: Christiansen
keywords: atrial natriuretic peptide; blood pressure; glucagon-like peptide-1; heart rate; kidney; natriuresis; proANP; proBNP