title: Refining a Jagged edge.
abstract: In a recent Cell Reports article, Chillakuri and colleagues showed that the N-terminal "MNNL" domain of the essential Notch ligand Jagged1 resembles a C2 domain and relies on calcium binding to facilitate productive signal transduction.
authors: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck Street, Boston, MA 02115, USA; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: stephen_blacklow@hms.harvard.edu.
authors: Stephen C
authors: SC
authors: Blacklow
mesh_terms: D002135:Calcium-Binding Proteins / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D050556:Fatty Acid-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins