title: Intravesical instillations with polydeoxyribonucleotides reduce symptoms of radiation-induced cystitis in patients treated with radiotherapy for pelvic cancer: a pilot study.
abstract: OBJECTIVE
  Chronic radiation cystitis (CRC) is a serious complication that can arise in patients with pelvic malignancies treated with radiotherapy. Polydeoxyribonucleotides (PDRNs) are known to reduce inflammation and improve tissue perfusion and angiogenesis. In this manuscript, we describe our observational experience regarding intravesical instillation of PDRNs in improving symptoms of CRC in subjects unresponsiveness to conventional medical therapy.
  
  
  METHODS
  Eight patients with persistent and/or worsening CRC symptoms, despite conventional therapy, received biweekly intravesical instillation of PDRNs for two consecutive months. Symptoms were scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale, before, at the end, and after 4 months following the PDRNs treatment.
  
  
  RESULTS
  Four months after instillations, a significant improvement in the subjective perception of CRC symptoms was experienced by participants. The mean LENT-SOMA score was reduced from 1.16+0.26 before to 0.34+0.035 after 4 months from instillations (p<0.001). No adverse effect related to instillations was reported.
  
  
  CONCLUSIONS
  Subjective perception of persistent and/or worsening CRC symptoms, despite conventional therapy, is improved after intravesical instillation with PDRNs without adverse events. Even though we deduced suggestive insights, the results need to be collected and verified from a large-scale study.
authors: Division of Radiotherapy, San Salvatore Hospital, 67100, L'Aquila, Italy, pier.bonfili@gmail.com.
authors: Pierluigi
authors: P
authors: Bonfili
authors: Pietro
authors: P
authors: Franzese
authors: Francesco
authors: F
authors: Marampon
authors: Maria Emilia
authors: ME
authors: La Verghetta
authors: Silvia
authors: S
authors: Parente
authors: Manuela
authors: M
authors: Cerasani
authors: Daniela
authors: D
authors: Di Genova
authors: Marta
authors: M
authors: Mancini
authors: Francesca
authors: F
authors: Vittorini
authors: Giovanni Luca
authors: GL
authors: Gravina
authors: Valeria
authors: V
authors: Ruggieri
authors: Mario
authors: M
authors: Di Staso
authors: Vladimir M
authors: VM
authors: Popov
authors: Vincenzo
authors: V
authors: Tombolini
authors: Ernesto
authors: E
authors: Di Cesare
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D010388:Pelvis / Q000528:radiation effects; D010865:Pilot Projects; D011089:Polydeoxyribonucleotides / Q000008:administration & dosage*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D011089:Polydeoxyribonucleotides