title: Maillard reaction inhibitors produced by Paecilomyces sp.
abstract: Maillard reaction inhibitors could be useful therapeutics for diabetes and other age-related diseases. We isolated for the first time 4-O-demethylsilvaticol (1) and (-)-mitorubrin (2) as Maillard reaction inhibitors from Paecilomyces sp. 3193B. Among the isolated inhibitors, 2 showed most potent inhibitory effect by an SDS-PAGE assay on cross-linked protein formation and by a fluorescent assay on AGE formation.
authors: Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University.
authors: Daxin
authors: D
authors: Li
authors: Kengo
authors: K
authors: Shigetomi
authors: Shinya
authors: S
authors: Mitsuhashi
authors: Makoto
authors: M
authors: Ubukata
mesh_terms: D000818:Animals; D001565:Benzoates / Q000378:metabolism / Q000494:pharmacology; D001688:Biological Products / Q000378:metabolism* / Q000494:pharmacology*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D015416:Maillard Reaction / Q000187:drug effects*; D010143:Paecilomyces / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D001565:Benzoates; D001688:Biological Products; D017127:Glycation End Products, Advanced; D012710:Serum Albumin, Bovine; D005947:Glucose; C521221:mitorubrin