title: Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma.
abstract: A rapidly progressive motor-dominant neuropathy associated with IgM monoclonal antibody against gangliosides with disialosyl residues, GD3, GD1b, GT1b, and GQ1b, in a 60-year-old Japanese man with mantle cell lymphoma is reported. Plasma exchange and chemotherapy for mantle cell lymphoma were performed for the neuropathy and mantle cell lymphoma. After therapy, the motor neuropathy dramatically improved concurrently with substantial reduction of the antibody activities especially in reaction to GD1b. This is the first case report of neuropathy with anti-disialosyl IgM antibodies associated with mantle cell lymphoma, and plasma exchange and chemotherapy were effective.
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan.
authors: Akio
authors: A
authors: Mori
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan. Electronic address: yuji-u@juntendo.ac.jp.
authors: Yuji
authors: Y
authors: Ueno
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan.
authors: Takuma
authors: T
authors: Kuroki
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan.
authors: Yasunobu
authors: Y
authors: Hoshino
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan.
authors: Hideki
authors: H
authors: Shimura
authors: Department of Hematology, Juntendo University Urayasu Hospital, Japan.
authors: Yasunobu
authors: Y
authors: Sekiguchi
authors: Department of Hematology, Juntendo University Urayasu Hospital, Japan.
authors: Masaaki
authors: M
authors: Noguchi
authors: Department of Neurology, Kinki University Hospital, Japan.
authors: Yukihiro
authors: Y
authors: Hamada
authors: Department of Neurology, Kinki University Hospital, Japan.
authors: Susumu
authors: S
authors: Kusunoki
authors: Department of Neurology, Juntendo University School of Medicine, Japan.
authors: Nobutaka
authors: N
authors: Hattori
authors: Department of Neurology, Juntendo University Urayasu Hospital, Japan.
authors: Takao
authors: T
authors: Urabe
mesh_terms: D015703:Antigens, CD / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D020522:Lymphoma, Mantle-Cell / Q000097:blood / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000209:etiology*; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D015703:Antigens, CD; D007075:Immunoglobulin M
keywords: Anti-disialosyl antibody; Anti-ganglioside antibody; Mantle cell lymphoma; Motor-dominant neuropathy; Plasma exchange; Sensory–motor neuropathy