title: Dual-phase cone-beam computed tomography to see, reach, and treat hepatocellular carcinoma during drug-eluting beads transarterial chemo-embolization.
abstract: The advent of cone-beam computed tomography (CBCT) in the angiography suite has been revolutionary in interventional radiology. CBCT offers 3 dimensional (3D) diagnostic imaging in the interventional suite and can enhance minimally-invasive therapy beyond the limitations of 2D angiography alone. The role of CBCT has been recognized in transarterial chemo-embolization (TACE) treatment of hepatocellular carcinoma (HCC). The recent introduction of a CBCT technique: dual-phase CBCT (DP-CBCT) improves intra-arterial HCC treatment with drug-eluting beads (DEB-TACE). DP-CBCT can be used to localize liver tumors with the diagnostic accuracy of multi-phasic multidetector computed tomography (M-MDCT) and contrast enhanced magnetic resonance imaging (CE-MRI) (See the tumor), to guide intra-arterially guidewire and microcatheter to the desired location for selective therapy (Reach the tumor), and to evaluate treatment success during the procedure (Treat the tumor). The purpose of this manuscript is to illustrate how DP-CBCT is used in DEB-TACE to see, reach, and treat HCC.
authors: Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Hospital.
authors: Vania
authors: V
authors: Tacher
authors: Mingde
authors: M
authors: Lin
authors: Nikhil
authors: N
authors: Bhagat
authors: Nadine
authors: N
authors: Abi Jaoudeh
authors: Alessandro
authors: A
authors: Radaelli
authors: Niels
authors: N
authors: Noordhoek
authors: Bart
authors: B
authors: Carelsen
authors: Bradford J
authors: BJ
authors: Wood
authors: Jean-François
authors: JF
authors: Geschwind
mesh_terms: D000792:Angiography / Q000295:instrumentation / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D054893:Cone-Beam Computed Tomography / Q000379:methods; D004317:Doxorubicin / Q000008:administration & dosage; D005471:Fluoroscopy / Q000379:methods; D006499:Hepatic Artery / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D004317:Doxorubicin