title: Ultrasound-guided percutaneous microwave ablation for submucosal uterine fibroids.
abstract: OBJECTIVE
  To prospectively evaluate the efficiency and safety of ultrasound-guided percutaneous microwave ablation (PMWA) in treating symptomatic submucosal uterine myomas.
  
  
  METHODS
  Self-controlled study (Canadian Task Force classification II-1).
  
  
  METHODS
  Single center.
  
  
  METHODS
  Twenty-two premenopausal women with 22 symptomatic submucosal uterine myomas.
  
  
  METHODS
  All patients underwent ultrasound-guided PMWA.
  
  
  RESULTS
  PMWA was performed in 22 premenopausal women with 22 symptomatic submucosal uterine myomas. Mean (SD) patient age was 42 (4.60) years (95% confidence interval [CI], 39.96-44.04). Five symptomatic submucosal uterine myomas were identified as type 0, 7 as type 1, and 10 as type 2. Contrast-enhanced ultrasound and magnetic resonance imaging were performed before and after surgery. Myoma volume, hemoglobin concentration, and scores on the UFS-QOL (Uterine Fibroid Symptom and Quality of Life) questionnaire were recorded before and at 3 and 12 months after ablation. Complications were also recorded. In all patients, therapy was completed with a single ablation. The baseline diameter of the symptomatic submucosal uterine myomas was 4.90 (1.60) cm. Mean myoma volume reduction rate was 81.46% (16.33%) (95% CI, 73.06%-89.86%) at 3 months (p < .001) and reached 90.00% (9.79%) (95% CI, 85.07-95.13) at 12 months (p < .001). At 3 months after ablation, hemoglobin concentration increased from 88.64 (21.87) g/L (95% CI, 78.94-98.34) to 123.21 (15.77) g/L (95% CI, 115.10-131.32) (p < .001), and remained stable at 12 months, with a value of 125.92 (14.90) g/L (95% CI, 117.98-133.86). Scores on the UFS-QOL were comparable, with normal levels observed at 1 year. No major complications were observed. Nine patients were discharged with necrotic masses.
  
  
  CONCLUSIONS
  PMWA seems to be effective and safe for treatment of submucosal myomas.
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Yu
authors: Y
authors: Yang
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China. Electronic address: zjbch@sina.com.
authors: Jing
authors: J
authors: Zhang
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Zhi-yu
authors: ZY
authors: Han
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Ming-an
authors: MA
authors: Yu
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Xia
authors: X
authors: Ma
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Hong-yu
authors: HY
authors: Zhou
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Yan-li
authors: YL
authors: Hao
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Lan
authors: L
authors: Zhao
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Xue-juan
authors: XJ
authors: Dong
authors: Department of Interventional Ultrasonics, Chinese PLA General Hospital, Beijing, China.
authors: Hai-long
authors: HL
authors: Ge
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D009214:Myoma; D017697:Premenopause; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D014594:Uterine Neoplasms / Q000601:surgery*
keywords: Ablation; Leiomyoma; Microwave; Ultrasound