title: N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case-control studies.
abstract: Previous evidence indicated that N-acetyltransferase 2 (NAT2) polymorphisms might be a risk factor for several cancers. A number of studies have been conducted on the association between NAT2 polymorphisms and head and neck cancer (HNC) risk. Nevertheless, the results were conflicting. Published meta-analysis on this issue has generated inconclusive results. Thus, we aimed to derive a more precise estimation of the relationship by conducting an updated meta-analysis. Published data prior to August 2013 have been searched and screened. Subgroup analysis on ethnicity, source of controls, sample size, and genotyping method were also performed. As a result, a total of 23 case-control studies including 4,028 cases and 4,872 controls were selected for analysis. Interestingly, the results showed that NAT2 polymorphisms might increase HNC risk for the overall data (OR 1.23, 95% CI 1.01-1.49). Moreover, in subgroup analyses according to ethnicity, data showed that slow acetylators might increase HNC susceptibility among Asians (OR 1.78, 95% CI 1.27-2.49), but not among Caucasians or mixed ethnicities. In conclusion, NAT2 polymorphism might be a low-penetrant risk factor for HNC among Asians.
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
authors: Liang
authors: L
authors: Zhang
authors: Zhaolan
authors: Z
authors: Xiang
authors: Rui
authors: R
authors: Hao
authors: Ru
authors: R
authors: Li
authors: Yi
authors: Y
authors: Zhu
mesh_terms: D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human