title: The risk factors of severe acute kidney injury induced by cisplatin.
abstract: OBJECTIVE
  We reported that the KDIGO (Kidney Disease: Improving Global Outcomes) criteria could stratify the risk of mortality in acute kidney injury (AKI) caused by cisplatin. The purpose of this study was to investigate risk factors of severe cisplatin-induced AKI (CIA).
  
  
  METHODS
  From January 2006 to December 2012, we identified Japanese cancer patients who were treated with cisplatin as a first-line chemotherapy at Nagoya University Hospital. Serum creatinine levels were used to define CIA.
  
  
  RESULTS
  We evaluated 1,721 patients treated with cisplatin. In multivariable analysis, cisplatin dosages/m(2) [odds ratio (OR) 1.019] or diagnosis of cancer stage 4 (OR 1.797) were risk factors of moderate CIA. History of diabetes mellitus (OR 3.454), history of cardiovascular disease (OR 3.612) or diagnosis of cancer stage 4 (OR 2.610) were risk factors of severe CIA.
  
  
  CONCLUSIONS
  Diabetes mellitus, cardiovascular disease and advanced cancer increased the risk of severe CIA. As severe CIA shortens the survival period, we should consider whether the use of cisplatin benefits these patients.
authors: Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
authors: Tomohiro
authors: T
authors: Mizuno
authors: Kazuhiro
authors: K
authors: Ishikawa
authors: Waichi
authors: W
authors: Sato
authors: Takahiro
authors: T
authors: Koike
authors: Mayu
authors: M
authors: Kushida
authors: Yasuhiro
authors: Y
authors: Miyagawa
authors: Kiyofumi
authors: K
authors: Yamada
authors: Sumio
authors: S
authors: Hirata
authors: Enyu
authors: E
authors: Imai
authors: Yukihiro
authors: Y
authors: Noda
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000401:mortality; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin