title: Clinical efficacy of autologous plasma therapy for atopic dermatitis.
abstract: BACKGROUND
  The clinical efficacy of autologous blood therapy (ABT) in patients with atopic dermatitis (AD) was demonstrated by a randomized double-blind placebo-controlled study. To characterize the blood component mediating the therapeutic efficacy of ABT for AD, we evaluated the clinical efficacy of autologous plasma therapy (APT) and autologous high-molecular-weight plasma protein fraction therapy (AHPT) in patients with AD in this study.
  
  
  METHODS
  A total of 22 patients with recalcitrant AD were treated with 8 weekly intramuscular injections of either autologous plasma (n = 11) or autologous high-molecular-weight plasma protein fraction (n = 11) for 7 weeks.
  
  
  RESULTS
  The clinical severity score of AD (SCORAD value) of 11 patients who completed AHPT significantly decreased from 79.7 ± 17.0 (mean ± SD) at baseline to 65.8 ± 16.4 at 6 weeks and 60.1 ± 16.0 at 7 weeks (Wilcoxon signed-rank test, p < 0.05). There were no significant differences among the SCORAD values measured at baseline (74.2 ± 19.6), at 6 weeks (66.3 ± 23.6) and at 7 weeks (67.5 ± 20.8) in 10 patients who completed APT (p > 0.05).
  
  
  CONCLUSIONS
  This result suggests that the blood component mediating the therapeutic efficacy of ABT in patients with AD might be present in the high-molecular-weight plasma protein fraction.
authors: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Su-Mi
authors: SM
authors: Cho
authors: Myoung-Eun
authors: ME
authors: Kim
authors: Jin-Young
authors: JY
authors: Kim
authors: Jun-Chul
authors: JC
authors: Park
authors: Dong-Ho
authors: DH
authors: Nahm
mesh_terms: D000328:Adult; D016913:Blood Component Transfusion / Q000379:methods*; D001798:Blood Proteins / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008970:Molecular Weight; D010949:Plasma / Q000737:chemistry; D011537:Pruritus / Q000150:complications; D011788:Quality of Life; D012720:Severity of Illness Index; D012890:Sleep; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D007136:Immunoglobulins