title: [Sentinel lymph node biopsy in pregnancy-associated breast cancer].
abstract: The incidence of pregnancy-associated breast cancer is rising. Sentinel lymph node biopsy is the method of choice in clinically node negative cases as the indicated minimally invasive regional staging procedure. Some reports have linked radioisotope and blue dye required for lymphatic mapping to teratogenic effects, the idea of which has become a generalized statement and, until recently, contraindication for these agents was considered during pregnancy. Today, there are many published reports of successful interventions with low-dose 99mTc-labeled human albumin nanocolloid, based on dosimetric modeling demonstrating a negligible radiation exposure of the fetus. These results contributed to the seemingly safe and successful use of sentinel lymph node biopsy during pregnancy, though generally it can not replace axillary lymphadenectomy in the absence of high-quality evidence. The possibility of sentinel lymph node biopsy should be offered to pregnancy-associated early breast cancer patients with clinically negative axilla, and patients should be involved in the decision making following extensive counselling. This paper presents the successful use of sentinel lymph node biopsy with low-dose tracer during two pregnancies (in the first and third trimesters) and, for the first time in Hungarian language, it offers a comprehensive literature review on this topic. Orv. Hetil., 154(50), 1991-1997.
authors: Országos Onkológiai Intézet Emlő- és Lágyrészsebészeti Osztály Budapest Ráth György u. 7-9. 1122.
authors: Zoltán
authors: Z
authors: Mátrai
authors: Ferenc
authors: F
authors: Bánhidy
authors: Melinda
authors: M
authors: Téglás
authors: Eszter
authors: E
authors: Kovács
authors: Akos
authors: A
authors: Sávolt
authors: Nóra
authors: N
authors: Udvarhelyi
authors: Alexandra
authors: A
authors: Bartal
authors: Miklós
authors: M
authors: Kásler
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D011247:Pregnancy; D021701:Sentinel Lymph Node Biopsy
keywords: 99mTc-jelölt humán albumin; 99mTc-labeled human albumin; pregnancy-associated breast cancer; sentinel lymph node biopsy; terhességi emlőrák; őrszemnyirokcsomó-biopszia