title: Concepts of tissue injury and cell death in inflammation: a historical perspective.
abstract: Emerging evidence indicates that the molecular mechanisms of cell death have regulatory roles in inflammation and that the molecular changes that are associated with different forms of cell death affect the course of inflammation in different ways. In this Timeline article, we discuss how our understanding of the mechanisms and functional roles of tissue injury and cell death in inflammation has evolved on the basis of almost two centuries of study. We describe how such ideas have led to our current models of cell death and inflammation, and we highlight the remaining gaps in our knowledge of the subject.
authors: Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
authors: David
authors: D
authors: Wallach
authors: Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, South Korea.
authors: Tae-Bong
authors: TB
authors: Kang
authors: Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
authors: Andrew
authors: A
authors: Kovalenko
mesh_terms: D000818:Animals; D016923:Cell Death / Q000276:immunology; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007249:Inflammation / Q000266:history* / Q000276:immunology / Q000473:pathology; D018448:Models, Immunological; D015398:Signal Transduction