title: BDNF in quinolinic acid lesioned rats after bone marrow cells transplant.
abstract: Brain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells (BMSC). The results showed a significant increase of the BDNF levels in the striatum and cortex of the lesioned animals and the ability of the transplanted cells to increase the levels of BDNF in both sites. This recovery of BDNF production and distribution might have beneficial effects and ameliorate the negative consequences of the striatal lesion, a mechanism of potential interest for the treatment of Huntington's disease (HD).
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
authors: T
authors: T
authors: Serrano Sánchez
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
authors: E
authors: E
authors: Alberti Amador
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
authors: L
authors: L
authors: Lorigados Pedre
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
authors: L
authors: L
authors: Blanco Lezcano
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba.
authors: I
authors: I
authors: Diaz Armesto
authors: International Center for Neurological Restauration (CIREN), Ave 25 # 15805 entre 158 y 160, Cubanacán, Playa, La Habana, Cuba. Electronic address: bergado@neuro.ciren.cu.
authors: J A
authors: JA
authors: Bergado
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000601:surgery; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000601:surgery; D008297:Male; D017378:Quinolinic Acid / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017378:Quinolinic Acid
keywords: Bone marrow stem cells (BMC); Brain-derived neurotrophic factor (BDNF); Huntington's disease (HD); Quinolinic acid; Transplant