title: Regulation of renal function and structure by the signaling Na/K-ATPase.
abstract: The Na/K-ATPase as an essential ion pump was discovered more than 50 years ago (Skou (1989) Biochim. Biophys. Acta 1000, 439-446; Feraille and Doucet (2001) Physiol. Rev. 81, 345-418). The signaling function of Na/K-ATPase has been gradually appreciated over the last 20 years, first from the studies of regulatory effects of ouabain on cardiac cell growth. Several reviews on this topic have been written during the last few years (Schoner and Scheiner-Bobis (2007) Am. J. Physiol. Cell. Physiol. 293, C509-C536; Xie and Cai (2003) Mol. Interv. 3, 157 - 168; Bagrov et al. (2009) Pharmacol. Rev. 61, 9-38; Tian and Xie (2008) Physiology 23, 205-211; Fontana et al. (2013) FEBS J. 280, 5450-5455; Blanco and Wallace (2013) Am. J. Physiol. Renal Physiol. 305, F797-F812). This article will focus on the molecular mechanism of Na/K-ATPase-mediated signal transduction and its potential regulatory role in renal physiology and diseases.
authors: Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA.
authors: Jeffrey X
authors: JX
authors: Xie
authors: Xin
authors: X
authors: Li
authors: Zijian
authors: Z
authors: Xie
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D019061:src-Family Kinases; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Na/K-ATPase; Src; cardiotonic steroids; cell growth; fibrosis; salt; signal transduction