title: A comparison of outcomes from in vitro fertilization cycles stimulated with either recombinant luteinizing hormone (LH) or human chorionic gonadotropin acting as an LH analogue delivered as human menopausal gonadotropins, in subjects with good or poor ovarian reserve: a retrospective analysis.
abstract: OBJECTIVE
  To compare rates of pregnancy and IVF parameters in subjects who were stimulated with FSH plus recombinant human luteinizing hormone or menopausal gonadotropins. To determine whether responses to type of LH differ in poor or good responders.
  
  
  METHODS
  Retrospective analysis at a university-based fertility center. Subjects were women with good and poor ovarian reserve, who underwent in vitro fertilization during a 2 year period, as part of a long agonist (N=122), or microdose flair (N=79) protocol. Measurements included FSH and LH dose, number of oocytes collected, number of embryos obtained, and pregnancy and clinical pregnancy rates.
  
  
  RESULTS
  Patients treated with r-hLH (n=105) had higher numbers of eggs retrieved and of embryos while using less FSH than their hMG-treated (n=96) counterparts. Pregnancy and clinical pregnancy rates were significantly higher with r-hLH than with hMG protocols (p=0.008 and 0.009, respectively). If patients had a baseline serum FSH level ≥10IU/L, clinical pregnancy rates were higher when r-hLH was used. When the antral follicle count was below 6 no significant differences in stimulation parameters or outcomes were detected between the groups.
  
  
  CONCLUSIONS
  r-hLH may be beneficial when compared to hMG and used for in-vitro fertilization, except in subjects with baseline follicle counts less than 6. Further data should be obtained.
authors: McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada. Electronic address: michael.dahan@muhc.mcgill.ca.
authors: Michael H
authors: MH
authors: Dahan
authors: McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada.
authors: Mohammed
authors: M
authors: Agdi
authors: McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada.
authors: Fady
authors: F
authors: Shehata
authors: McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada.
authors: Weonyoung
authors: W
authors: Son
authors: McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada.
authors: Seang Lin
authors: SL
authors: Tan
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007986:Luteinizing Hormone / Q000627:therapeutic use*; D008596:Menotropins / Q000627:therapeutic use*; D054315:Oocyte Retrieval / Q000379:methods; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D011994:Recombinant Proteins; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Human menopausal gonadotropins; IVF outcomes; Ovarian stimulation; Recombinant luteinizing hormone