title: [Co-administration of RJR-2403 with low dose of 17beta-estradiol on spatial learning in ovariectomized rats].
abstract: The aim of this work was to study the influence of stimulation or blockade Nalpha7-cholinoreceptors on dynamics of spatial learning in water Morris maze and on behavior in the "open field" test in adult ovariectomized (OVX) females given with a low dose of 17beta-estradiol. Agonist of Nalpha7-cholinoreceptors - RJR-2403 (1.0 mg/kg, i.p.) or antagonist of Nalpha7-cholinoreceptors - mecamylamine (1.0 mg/kg, i.p.) treated chronically (14 days) alone and in a combination with low dose of 17beta-estradiol (0.5 micro/rat, s.c.) to OVX rats. Co-administration of RJR-2403 with low dose of 17beta-estradiol completely restored impaired spatial learning in water Morris maze in OVX females. Moreover, OVX rats treated with RJR-2403 and low dose of 17beta-estradiol demonstrated increased exploratory and grooming behavior in the "open field" test. Both mecamylamine alone and in combination with low dose of 17beta-estradiol failed to influence on spatial learning and failed to modify behavior in the "open field" test in OVX rats. The results of the present study suggest a positive effect of RJR-2403 in combination with low dose of 17beta-estradiol on spatial learning at estrogen deficiency.
authors: Yu O
authors: YO
authors: Fedotova
mesh_terms: D000818:Animals; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D006120:Grooming / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects*; D009538:Nicotine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018680:Cholinergic Antagonists; D004967:Estrogens; D004958:Estradiol; C012419:metanicotine; D009538:Nicotine