title: Changes in proteasome chymotrypsin-like activity during the development of human mammary and thyroid carcinomas.
abstract: Changes in the proteasome chymotrypsin-like activity in mammary and thyroid carcinomas in comparison with the adjacent tissue were studied at stages T(1-4)N(0-3)M(0) and T(2-3)N(0-1)M(0), respectively. The activities changed in a wave-like manner over the course of mammary carcinoma growth in cases with and without metastases. The minimum increment of the activity in the tumor was recorded during the T(2)N(0) stage in the absence of local metastases. The increment of the activity reached the peak in N(1) tumors of the same size with metastases. The activities in the tumor and adjacent tissues virtually did not differ during the T(3-4)N(1-3) stages. The time course of proteasome activity changes in thyroid tumors of the studied stages was similar to that in mammary carcinoma. The results can be used for development of methods for evaluating the aggressiveness of mammary and thyroid tumors.
authors: Research Cancer Institute, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; N. K. Koltsov Institute of Developmental Biology, the Russian Academy of Sciences; N. I. Pirogov Russian National Research Medical University, the Ministry of Health and Social Development of Russia, Moscow, Russia. npsharova@bk.ru.
authors: E E
authors: EE
authors: Shashova
authors: T M
authors: TM
authors: Astakhova
authors: A S
authors: AS
authors: Plekhanova
authors: Yu V
authors: YV
authors: Bogomyagkova
authors: Yu V
authors: YV
authors: Lyupina
authors: I R
authors: IR
authors: Sumedi
authors: E M
authors: EM
authors: Slonimskaya
authors: P A
authors: PA
authors: Erokhov
authors: E B
authors: EB
authors: Abramova
authors: G V
authors: GV
authors: Rodoman
authors: N A
authors: NA
authors: Kuznetsov
authors: I V
authors: IV
authors: Kondakova
authors: N P
authors: NP
authors: Sharova
authors: E L
authors: EL
authors: Choinzonov
mesh_terms: D001897:Boronic Acids / Q000494:pharmacology; D000069286:Bortezomib; D001940:Breast / Q000201:enzymology; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology*; D002918:Chymotrypsin / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011719:Pyrazines / Q000494:pharmacology; D013961:Thyroid Gland / Q000201:enzymology; D013964:Thyroid Neoplasms / Q000201:enzymology / Q000473:pathology*
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D002918:Chymotrypsin; D046988:Proteasome Endopeptidase Complex