title: Hyperhomocysteinemia and hyperlipoproteinemia (a) in obese South Indian men: an indication for increased cardiovascular risk.
abstract: Obesity is a pathological condition which increases the risk for cardiovascular disease. The present study was designed to evaluate homocysteine, lipoprotein (a) [Lp(a)], apolipoprotein-B (apo-B), apolipoprotein-A-I (apo-A-I) and lipid indices and their association if any in obese South Indian men. Thirty obese men and thirty age-matched males with normal body weight (controls) were recruited in the study. Plasma homocysteine, Lp(a), lipid profile, apo-A-I and apo-B were estimated in all the subjects. Lipid indices such as lipid pentad index (LPI), lipid tetrad index (LTI), atherogenic index of plasma (AIP), non-high density lipoprotein (non-HDL)/high density lipoprotein (HDL) ratio and apo-B/apo-A-I ratio were calculated in all study subjects. Homocysteine, Lp(a), apo-B, apo-B/apo-A-I ratio and lipid indices were significantly increased in obese men, compared to controls. Both homocysteine and Lp(a) were positively correlated with BMI, waist, hip circumference and apo-B and negatively correlated with apo-A-I. Also we found highly significant positive correlation between homocysteine and Lp(a) levels. The data from the present study concludes that non-conventional risk factors like homocysteine, Lp (a), apo-B/apo-A-I ratio, LTI, LPI, non-HDL/HDL ratio and AIP were significantly elevated in obese Indian men, suggesting they are more prone to develop cardiovascular disease, than the age-matched men with normal body weight.
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biochemistry Puducherry 605006 India.
authors: S
authors: S
authors: Ikkruthi
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biochemistry Puducherry 605006 India.
authors: Medha
authors: M
authors: Rajappa
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biochemistry Puducherry 605006 India.
authors: H
authors: H
authors: Nandeesha
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Cardiology Puducherry India.
authors: S
authors: S
authors: Satheesh
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biochemistry Puducherry 605006 India.
authors: I
authors: I
authors: Sundar
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biochemistry Puducherry 605006 India.
authors: P H
authors: PH
authors: Ananthanarayanan
authors: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Department of Biometrics Puducherry India.
authors: K T
authors: KT
authors: Harichandrakumar
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006951:Hyperlipoproteinemias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007194:India / Q000453:epidemiology; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D015854:Up-Regulation; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D017270:Lipoprotein(a); D006710:Homocysteine
keywords: Lp(a); apolipoproteins; homocysteine; lipid pentad index and lipid tetrad index; obesity