title: Correlation of apparent diffusion coefficient value with prognostic parameters of endometrioid carcinoma.
abstract: OBJECTIVE
  To correlate the apparent diffusion coefficient (ADC) of endometrioid carcinoma with histological tumor grade and degree of myometrial invasion.
  
  
  METHODS
  3T diffusion-weighted (DW) magnetic resonance (MR) images of 63 patients were retrospectively reviewed. Two readers measured tumor ADC according to a freehand region of interest (ROI) and a round ROI. Mean and minimum ADCs were correlated with prognostic parameters.
  
  
  RESULTS
  The minimum ADC was 0.64 × 10(-3) mm(2)/s for grade 1 (G1, n = 42), 0.62 for grade 2 (G2, n = 14), 0.46 for grade 3 (G3, n = 7) on freehand ROI. There were significant differences between G1 and G3 (P = 0.007), and G2 and G3 (P = 0.038). No significant correlation was found between tumor grade and mean ADC (0.85 for G1, 0.82 for G2, and 0.72 for G3, P = 0.166). The minimum ADC was significantly lower for patients with deep (n = 21, 0.54) than for those with superficial (n = 39, 0.65) myometrial invasion. Conversely, mean ADC did not differ significantly (0.84 for superficial and 0.78 for deep myometrial invasion, P = 0.081). The same tendency was shown on round ROI.
  
  
  CONCLUSIONS
  The minimum ADC correlates with prognostic parameters of endometrial carcinoma more strongly than mean ADC. Lower minimum ADC is associated with higher histological tumor grade and higher degree of myometrial invasion.
authors: Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Japan.
authors: Chie
authors: C
authors: Inoue
authors: Shinya
authors: S
authors: Fujii
authors: Sachi
authors: S
authors: Kaneda
authors: Takeru
authors: T
authors: Fukunaga
authors: Toshio
authors: T
authors: Kaminou
authors: Junzo
authors: J
authors: Kigawa
authors: Tasuku
authors: T
authors: Harada
authors: Toshihide
authors: T
authors: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D016889:Endometrial Neoplasms / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology; D060787:Neoplasm Grading; D015588:Observer Variation; D011379:Prognosis; D012189:Retrospective Studies
keywords: ADC; MR; apparent diffusion coefficient; diffusion; endometrioid carcinoma; prognostic parameters