title: Comparison of the skin penetration of Garcinia mangostana extract in particulate and non-particulate form.
abstract: The aim of the present study was to solve the water insolubility limitation of the medically and cosmetically interesting substance Garcinia mangostana Linn (GML) extract by encapsulation, and to evaluate and investigate the penetration efficacy of free and encapsulated GML in two different vehicles (water and cream) in porcine ear skin. The follicular penetration depth was determined in 50 hair follicles for each of the four formulations by means of fluorescence microscopy. Tape stripping was used to compare the distribution properties of GML with all formulations on the stratum corneum. The results showed that encapsulated and free GML in the cream base penetrated deeper into hair follicles than if applied in an aqueous base. In addition, encapsulated GML could be distributed more homogeneously on the stratum corneum than the free GML. In conclusion, it was found that encapsulated GML in a cream base had the most effective penetration level in porcine ear skin.
authors: Department of Chemistry, Chulalongkorn University, Bangkok, Thailand.
authors: Amornset
authors: A
authors: Tachaprutinun
authors: Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: Martina C
authors: MC
authors: Meinke
authors: Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: Heike
authors: H
authors: Richter
authors: Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors: Porntip
authors: P
authors: Pan-In
authors: Department of Chemistry, Chulalongkorn University, Bangkok, Thailand.
authors: Supason
authors: S
authors: Wanichwecharungruang
authors: Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: Fanny
authors: F
authors: Knorr
authors: Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: Jürgen
authors: J
authors: Lademann
authors: Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address: alexa.patzelt@charite.de.
authors: Alexa
authors: A
authors: Patzelt
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003358:Cosmetics / Q000737:chemistry / Q000378:metabolism; D029762:Garcinia mangostana / Q000737:chemistry*; D018859:Hair Follicle / Q000378:metabolism; D014677:Pharmaceutical Vehicles / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012995:Solubility; D013552:Swine; D014867:Water / Q000737:chemistry
chemical_list: D003358:Cosmetics; D014677:Pharmaceutical Vehicles; D010936:Plant Extracts; D014867:Water
keywords: Encapsulation; Ethylcellulose; Garcinia mangostana extract; Methylcellulose; Skin penetration; Tape stripping