title: Synchronous development of intrahepatic cholangiocarcinoma and hepatocellular carcinoma in different sites of the liver with chronic B-viral hepatitis: two case reports.
abstract: BACKGROUND
  Synchronous development of primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma has been reported rarely. In literature review, there have been only 35 reported cases of synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma, and most of these tumors developed in patients with hepatitis C-related liver cirrhosis. Here, we present synchronous development of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in two patients with chronic B-viral hepatitis.
  
  
  METHODS
  Two patients with chronic hepatitis B were referred to our hospital due to a hepatic mass. Patient 1 had a 6.4 cm multinodular hepatic mass in the left lobe and a small nodule in the right lobe. Patient 2 had a 4.3 cm hypervascular mass in the right lobe and a 1.1 cm nodule in the left lobe. The pre-operative diagnosis of both cases was hepatocellular carcinoma with metastatic nodule, however, surgical resection pathology revealed that hepatocellular carcinoma and intrahepatic cholangiocarcinoma existed independently in the other side of the liver in both cases. Additionally, the background liver histology of both cases was hepatitis B-related chronic hepatitis without cirrhotic change.
  
  
  CONCLUSIONS
  Our cases suggest that hepatitis B virus infection can also predispose to development of double liver cancers.
authors: Kyu Sik
authors: KS
authors: Jung
authors: Kyeong Hyeon
authors: KH
authors: Chun
authors: Gi Hong
authors: GH
authors: Choi
authors: Hyae Min
authors: HM
authors: Jeon
authors: Hye Sun
authors: HS
authors: Shin
authors: Young Nyun
authors: YN
authors: Park
authors: Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. drpjy@yuhs.ac.
authors: Jun Yong
authors: JY
authors: Park
mesh_terms: D000368:Aged; D018281:Cholangiocarcinoma / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications*