title: Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis.
abstract: 1297C/T polymorphism of CYP4F2 gene was studied in 108 patients with chronic liver diseases. No significant correlation with predisposition to rapid liver cirrhosis was revealed without consideration for cirrhosis etiology (OR=0.93, 95% CI=0.28-2.99, p=0.885). In patients with viral cirrhosis, a tendency to association of 1297T allele genotypes with rapid cirrhosis development was found (OR=6.0, 95% CI=0.28-382.64, p=0.222). At the same time, CYP4F2 1297T allele was associated with mild (Child-Pugh class A-B) cirrhosis (OR=2.9, p=0.044).
authors: Research Institute for Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences; Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences; Vektor-Best, Novosibirsk, Russia. drugsmet@soramn.ru.
authors: V A
authors: VA
authors: Vavilin
authors: D L
authors: DL
authors: Nepomnyashchikh
authors: E G
authors: EG
authors: Shchepotina
authors: Yu Yu
authors: YY
authors: Karavaeva
authors: S I
authors: SI
authors: Makarova
authors: E V
authors: EV
authors: Vinogradova
authors: A V
authors: AV
authors: Kudryashov
authors: Zh V
authors: ZhV
authors: Nokhrina
authors: V V
authors: VV
authors: Lyakhovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001095:Arachidonic Acids / Q000378:metabolism*; D063386:Cannabinoid Receptor Agonists / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D063388:Endocannabinoids / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053284:Polyunsaturated Alkamides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001095:Arachidonic Acids; D063386:Cannabinoid Receptor Agonists; D063388:Endocannabinoids; D053284:Polyunsaturated Alkamides; D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human; C078814:anandamide