title: Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade.
abstract: An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.
authors: School of Pharmacy, East China University of Science and Technology, 130 Mei-Long Road, Shanghai 200237, China.
authors: Long
authors: L
authors: Han
authors: Chuan
authors: C
authors: Liu
authors: Wei
authors: W
authors: Zhang
authors: Xiao-Xin
authors: XX
authors: Shi
authors: Shu-Li
authors: SL
authors: You
mesh_terms: D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism; D014639:Vanadium / Q000737:chemistry*; D000438:Alcohols
chemical_list: D004852:Epoxy Compounds; D007211:Indoles; D008024:Ligands; D014639:Vanadium; C005949:tryptophol; D000438:Alcohols