title: Comorbidities in children and adolescents with AIDS acquired by HIV vertical transmission in Vitória, Brazil.
abstract: BACKGROUND
  Studying diseases associated with AIDS is essential for establishing intervention strategies because comorbidities can lead to death. The objectives were to describe the frequency of comorbidities and verify their distribution according to demographic, epidemiological and clinical data as well as to classify diseases in children and adolescents with AIDS in Vitória, Brazil.
  
  
  METHODS
  A retrospective cohort study was conducted among children with AIDS, as defined according to the criteria established by the Ministry of Health, who acquired HIV via vertical transmission, were aged 0 to 18 years, and were monitored at a referral hospital from January 2001 to December 2011.
  
  
  RESULTS
  A total of 177 patients were included, of whom 97 were female (55%). There were 60 patients (34%) <1 year old, 67 patients (38%) between the ages of 1 and 5, and 50 patients (28%) ≥6 years of age included at the time of admission to the Infectious Diseases Ward. Regarding clinical-immunological classification, 146 patients (82.5%) showed moderate/severe forms of the disease at the time of admission into the Ward, and 26 patients (14.7%) died during the study. The most common clinical signs were hepatomegaly (81.62%), splenomegaly (63.8%), lymphadenopathy (68.4%) and persistent fever (32.8%). The most common comorbidities were anaemia (67.2%), pneumonia/septicaemia/acute bacterial meningitis (ABM) (64.2%), acute otitis media (AOM)/recurrent sinusitis (55.4%), recurrent severe bacterial infections (47.4%) and dermatitis (43.1%). An association between severe clinical-immunological classification and admission to the Ward for children aged less than one year old was found for several comorbidities (p<0.001).
  
  
  CONCLUSIONS
  Delayed diagnosis was observed because the majority of patients were admitted to the Infectious Diseases Ward at ≥1 year of age and were already presenting with serious diseases. The general paediatrician should be alert to this possibility to make an early diagnosis in children infected with HIV.
authors: Infectious Diseases Ward, Nossa Senhora da Glória State Children's Hospital (Serviço de Infectologia do Hospital Estadual Infantil Nossa Senhora da Glória - SI-HEINSG), Vitória-Espírito Santo (ES), Brazil ; Post-Graduate Program in Infectious Diseases, Federal University of Espírito Santo (Universidade Federal do Espírito Santo - UFES). Vitória-Espírito Santo (ES), Brazil.
authors: Sandra F
authors: SF
authors: Moreira-Silva
authors: Eliana
authors: E
authors: Zandonade
authors: Diana O
authors: DO
authors: Frauches
authors: Elisa A
authors: EA
authors: Machado
authors: Lays Ignacia A
authors: LI
authors: Lopes
authors: Lívia L
authors: LL
authors: Duque
authors: Polyana P
authors: PP
authors: Querido
authors: Angélica E
authors: AE
authors: Miranda
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology / Q000635:transmission* / Q000821:virology*; D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006678:HIV / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D013997:Time Factors