title: Total adiponectin, but not inflammatory markers C-reactive protein, tumor necrosis factor-α, interluekin-6 and monocyte chemoattractant protein-1, correlates with increasing glucose intolerance in pregnant Chinese-Americans.
abstract: BACKGROUND
  Elevated insulin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels and decreased high molecular weight adiponectin (HMW-APN) levels have been reported in Caucasians with gestational diabetes mellitus (GDM). No similar studies have been performed in Chinese women.
  
  
  METHODS
  Serum samples were obtained 1 h after a 50-g glucose challenge test (1HGCT) from Chinese-American women at 24-28 gestational weeks and total adiponectin (T-APN), HMW-APN, CRP, TNF-α, IL-6, and MCP-1 concentrations were measured. Correlation coefficients for glucose (1HGCT), HbA1c, insulin, and body mass index (BMI) were calculated against T-APN, HMW-APN, CRP, TNF-α, IL-6, and MCP-1. Significant P-values were determined using Bonferroni adjustments.
  
  
  RESULTS
  Women with GDM had higher insulin and 1HGCT and lower T-APN. In addition, T-APN was lower in non-GDM subjects who had 1HGCT ≥135 mg/dL with no abnormal or one abnormal glucose value on the 3-h oral glucose tolerance test. There were no significant differences in HMW-APN and inflammatory marker levels between non-GDM and GDM groups. There were negative correlations between T-APN and 1HGCT, insulin, BMI, and HbA1c, as well as between HMW-APN and 1HGCT, insulin, and BMI. No significant correlations were observed between 1HGCT, HbA1c, insulin, or BMI and CRP, TNF-α, IL-6, or MCP-1.
  
  
  CONCLUSIONS
  T-APN is reduced in Chinese women with GDM and those without GDM but with evidence of glucose intolerance. Unlike results reported for Caucasians, Chinese-American women with GDM do not exhibit elevated levels of CRP, TNF-α, IL-6, or MCP-1, possibly because Chinese women are relatively leaner compared with Caucasians.
authors: Division of Endocrinology and Friedman Diabetes Institute, Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, New York, New York, USA.
authors: So-Young
authors: SY
authors: Kim
authors: Vanessa
authors: V
authors: Sy
authors: Takako
authors: T
authors: Araki
authors: Nicole
authors: N
authors: Babushkin
authors: Diana
authors: D
authors: Huang
authors: Doris
authors: D
authors: Tan
authors: Emilia
authors: E
authors: Liao
authors: George
authors: G
authors: Liu
authors: Stephen
authors: S
authors: Wan
authors: Leonid
authors: L
authors: Poretsky
authors: Donna
authors: D
authors: Seto-Young
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001213:Asian; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D018932:Chemokine CCL2; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C111835:CCL2 protein, human
keywords: Chinese pregnant women; HMW-adiponectin; T-adiponectin; gestational diabetes; glucose intolerance; inflammatory markers; 华裔妊娠妇女，妊娠糖尿病，葡萄糖耐量，HMW-脂联素，炎症标志物，T-脂联素