title: Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women.
abstract: The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e.g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and β-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50-76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50-76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the cross-sectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the β-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the β-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.
authors: Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan;
authors: Tomoko
authors: T
authors: Matsubara
authors: Asako
authors: A
authors: Miyaki
authors: Nobuhiko
authors: N
authors: Akazawa
authors: Youngju
authors: Y
authors: Choi
authors: Song-Gyu
authors: SG
authors: Ra
authors: Koichiro
authors: K
authors: Tanahashi
authors: Hiroshi
authors: H
authors: Kumagai
authors: Satoshi
authors: S
authors: Oikawa
authors: Seiji
authors: S
authors: Maeda
mesh_terms: D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D000090265:Klotho Proteins; D008875:Middle Aged; D010101:Oxygen Consumption; D017698:Postmenopause / Q000097:blood / Q000502:physiology*; D059289:Vascular Stiffness
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Klotho; aerobic exercise; arterial stiffness