title: Role of cAMP and IKK-2-dependent signaling in the realization of growth potential of mesenchymal progenitor cells.
abstract: We studied the role of cAMP- and IKK-2-mediated pathways in the realization of growth potential of mesenchymal progenitor cells in vitro. It had been found that adenylate cyclase inhibitor 2',5'-dideoxyadenosine had no effect on the proliferation and differentiation of fibroblastic CFU. A decrease in differentiation rate of progenitor cells was observed after the treatment with specific IKK-2 blocker inhibitor-kinase complex.
authors: Research Institute of Pharmacology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia. zgn@pharm.tsu.ru.
authors: G N
authors: GN
authors: Zyuz'kov
authors: V V
authors: VV
authors: Zhdanov
authors: M G
authors: MG
authors: Danilets
authors: E V
authors: EV
authors: Udut
authors: L A
authors: LA
authors: Miroshnichenko
authors: A A
authors: AA
authors: Ligacheva
authors: E V
authors: EV
authors: Simanina
authors: E S
authors: ES
authors: Trofimova
authors: M Yu
authors: MY
authors: Minakova
authors: A V
authors: AV
authors: Chaikovskii
authors: A M
authors: AM
authors: Dygai
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D000242:Cyclic AMP / Q000378:metabolism; D016048:Dideoxyadenosine / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D016048:Dideoxyadenosine; D000242:Cyclic AMP; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse; D000262:Adenylyl Cyclases