title: A closed-loop control scheme for steering steady states of glycolysis and glycogenolysis pathway.
abstract: Biochemical networks normally operate in the neighborhood of one of its multiple steady states. It may reach from one steady state to other within a finite time span. In this paper, a closed-loop control scheme is proposed to steer states of the glycolysis and glycogenolysis (GG) pathway from one of its steady states to other. The GG pathway is modeled in the synergism and saturation system formalism, known as S-system. This S-system model is linearized into the controllable Brunovsky canonical form using a feedback linearization technique. For closed-loop control, the linear-quadratic regulator (LQR) and the linear-quadratic gaussian (LQG) regulator are invoked to design a controller for tracking prespecified steady states. In the feedback linearization technique, a global diffeomorphism function is proposed that facilitates in achieving the regulation requirement. The robustness of the regulated GG pathway is studied considering input perturbation and with measurement noise.
authors: Indian Institute of Technology, Kharagpur.
authors: Surajit
authors: S
authors: Panja
authors: Indian Institute of Technology, Kharagpur.
authors: Sourav
authors: S
authors: Patra
authors: Indian Institute of Technology, Kharagpur.
authors: Anirban
authors: A
authors: Mukherjee
authors: University of Calcutta, Kolkata.
authors: Madhumita
authors: M
authors: Basu
authors: University of Calcutta, Kolkata.
authors: Sanghamitra
authors: S
authors: Sengupta
authors: Indian Institute of Technology, Kharagpur.
authors: Pranab K
authors: PK
authors: Dutta
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005246:Feedback; D050261:Glycogenolysis / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology*; D016014:Linear Models; D008954:Models, Biological