title: Tubulin inhibitors: a patent review.
abstract: BACKGROUND
  Microtubules play an important role in several cellular processes, particularly in the formation of the mitotic spindle during the process of mitosis. These highly dynamic mitotic-spindle microtubules have become a successful target of cancer therapy. Microtubule-targeting agents, such as vinca alkaloids and taxanes, were used in clinic over 50 years. In past decades, development of new antimicrotubule agents that possess different structure and binding sites of tubulin has shown potent activity against the proliferation of various cancer cells, as well as in multidrug-resistant cancers. Interestingly, many of these agents represent an attractive ability that targeting the tumor blood vessels results in tumor vascular disruption. Therefore, exploring new agents and strategies may provide more effective therapeutic options in the related treatment of cancer.
  
  
  METHODS
  In past few years, there are many chemical compounds that successfully interferes the microtubules and display antitumor effect. In these, published compounds supply the fresh minds in modification of present drugs and new insights into the development of tubulin inhibitors.
  
  
  CONCLUSIONS
  This article arranges the microtubule-targeting agents that have published in patent in recent years. It may help in the investigation of new tubulin binding site and development of novel drug candidate in the future.
authors: Taipei Medical University, School of Pharmacy, College of Pharmacy , 250 Wuxing Street, Taipei 11031, Taiwan , Republic of China +886 2 2736 1661, ext 6130 ; jpl@tmu.edu.tw.
authors: Yi-Min
authors: YM
authors: Liu
authors: Hsiao-Ling
authors: HL
authors: Chen
authors: Hsueh-Yun
authors: HY
authors: Lee
authors: Jing-Ping
authors: JP
authors: Liou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007880:Legislation, Drug; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010330:Patents as Topic; D013329:Structure-Activity Relationship; D050257:Tubulin Modulators / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D050257:Tubulin Modulators