title: Hepatic steatosis: effect on hepatocyte enhancement with gadoxetate disodium-enhanced liver MR imaging.
abstract: OBJECTIVE
  To investigate the effect of hepatic steatosis on enhancement of liver parenchyma with gadoxetate disodium-enhanced MR imaging.
  
  
  METHODS
  Gadoxetate disodium-enhanced MR images of 166 patients were analyzed. Liver-spleen contrast and liver-spleen relative enhancement ratio on three-dimensional gradient echo T1-weighted images with fat suppression 20 minutes after injection of gadoxetate disodium were evaluated in correlation with fat signal fraction using the Pearson correlation coefficient and also compared between patients with normal liver parenchyma (n = 115) and with liver steatosis (n = 51) using the Student t-test.
  
  
  RESULTS
  The liver-spleen contrast at hepatobiliary phase showed inverse correlations with the fat signal fraction (r = -0.36; P < 0.01), while the liver-spleen relative enhancement ratio showed no statistical correlation with the fat signal fraction (P = 0.80). The liver-spleen contrast in the group with steatotic liver was significantly lower than that in the group with normal livers (P < 0.001). There was no significant difference in the relative enhancement ratio between the two groups (P = 0.85).
  
  
  CONCLUSIONS
  Our results may suggest that hepatic steatosis does not affect the uptake of gadoxetate disodium into hepatocytes and are considered crucial as background knowledge in extending the use of gadoxetate disodium-enhanced MR imaging to quantitate liver function.
authors: Institute for Clinical Radiology, Ludwig Maximilians-University Hospital Munich, Germany; Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Hiromitsu
authors: H
authors: Onishi
authors: Daniel
authors: D
authors: Theisen
authors: Olaf
authors: O
authors: Dietrich
authors: Maximilian F
authors: MF
authors: Reiser
authors: Christoph J
authors: CJ
authors: Zech
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000737:chemistry; D005234:Fatty Liver / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D019786:Gadolinium DTPA / Q000737:chemistry*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007089:Image Enhancement; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology; D055815:Young Adult
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Dixon technique; gadoxetate disodium (Gd-EOB-DTPA); liver; magnetic resonance imaging; steatosis