title: Long-term survival of patients with hepatocellular carcinoma with inferior vena cava tumor thrombus treated with sorafenib combined with transarterial chemoembolization: report of two cases and literature review.
abstract: The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus formation in the main vasculature is extremely poor. Sorafenib combined with transarterial chemoembolization is a novel treatment approach for advanced HCC. In this study, we report two HCC patients with inferior vena cava tumor thrombus who underwent the combination treatment. The overall survival times for these two patients were 44 months and 35 months, respectively. Our report suggests that sorafenib combined with transarterial chemoembolization may be a viable choice for patients with advanced HCC even with inferior vena cava tumor thrombus. Further studies are required to verify the efficacy and safety of this combination therapy for patients with advanced HCC with inferior vena cava tumor thrombus.
authors: Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51060, P. R. China. xuli@sysucc.org.cn.
authors: Heng-Jun
authors: HJ
authors: Gao
authors: Li
authors: L
authors: Xu
authors: Yao-Jun
authors: YJ
authors: Zhang
authors: Min-Shan
authors: MS
authors: Chen
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002406:Catheterization, Peripheral; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011379:Prognosis; D000077157:Sorafenib; D013927:Thrombosis; D014682:Vena Cava, Inferior
chemical_list: D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib