title: (9)Be(d,n)(10)B-based neutron sources for BNCT.
abstract: In the frame of accelerator-based BNCT, the (9)Be(d,n)(10)B reaction was investigated as a possible source of epithermal neutrons. In order to determine the configuration in terms of bombarding energy, target thickness and Beam Shaping Assembly (BSA) design that results in the best possible beam quality, a systematic optimization study was carried out. From this study, the optimal configuration resulted in tumor doses ≥40Gy-Eq, with a maximum value of 51Gy-Eq at a depth of about 2.7cm, in a 60min treatment. The optimal configuration was considered for the treatment planning assessment of a real Glioblastoma Multiforme case. From this, the resulted dose performances were comparable to those obtained with an optimized (7)Li(p,n)-based neutron source, under identical conditions and subjected to the same clinical protocol.
authors: Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina. Electronic address: capoulat@tandar.cnea.gov.ar.
authors: M E
authors: ME
authors: Capoulat
authors: Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
authors: M S
authors: MS
authors: Herrera
authors: Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
authors: D M
authors: DM
authors: Minsky
authors: Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
authors: S J
authors: SJ
authors: González
authors: Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
authors: A J
authors: AJ
authors: Kreiner
mesh_terms: D001895:Boron / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007554:Isotopes / Q000627:therapeutic use; D008422:Materials Testing; D009502:Neutrons / Q000627:therapeutic use; D010315:Particle Accelerators / Q000295:instrumentation*; D011874:Radiometry / Q000295:instrumentation*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012542:Scattering, Radiation
chemical_list: D007554:Isotopes; D001895:Boron
keywords: (9)Be(d,n)(10)B reaction; Accelerator-based BNCT; Beam-Shaping-Assembly; Brain tumor treatment; Monte-Carlo-simulations