title: Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestational age infants.
abstract: Congenital cytomegalovirus (CMV) infection affects many organs: reticuloendothelial and central nervous system are particularly involved. Congenital CMV infection is the leading cause of non-genetic sensorineural hearing loss. Hearing impairment can be present at birth or it can occur months or even years after birth. It is as well an important risk factor for antenatal stillbirth, preterm birth and small for gestational age (SGA) condition. For these reasons we should early identify congenital CMV infection investigating at least at risk newborns such as preterm or SGA babies given that a simple and standardized method for a large scale screening program is lacking. In our study, we found an association between congenital CMV infection and preterm births (3.03%) and with SGA condition (3.7%). Consequently, routine CMV urine detection should be performed at least in all babies born before 37 weeks of gestational age and in term SGA newborns.
authors: Neonatal Unit and Neonatal Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa , Pisa , Italy and.
authors: F
authors: F
authors: Lorenzoni
authors: S
authors: S
authors: Lunardi
authors: A
authors: A
authors: Liumbruno
authors: G
authors: G
authors: Ferri
authors: V
authors: V
authors: Madrigali
authors: E
authors: E
authors: Fiorentini
authors: F
authors: F
authors: Forli
authors: S
authors: S
authors: Berrettini
authors: A
authors: A
authors: Boldrini
authors: P
authors: P
authors: Ghirri
mesh_terms: D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology / Q000652:urine; D006320:Hearing Tests; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007558:Italy / Q000453:epidemiology; D015997:Neonatal Screening
keywords: Asymptomatic infection; CMV urine detection; hearing loss; hearing screening test; newborn