title: Expression of EMMPRIN modulates mediators of tumor invasion in oral squamous cell carcinoma.
abstract: Squamous cell carcinoma (SCC) accounts for 96 percent of all intraoral malignancies. The five-year survival rate is 50 percent and has not improved in 60 years. During SCC progression, subsets of SCC cells undergo an epithelial-to-mesenchymal transition (EMT) to become highly invasive. The extracellular matrix metalloproteinase inducer (EMMPRIN) contributes to EMT by activating local matrix metalloproteinases (MMPs). In this study, we found that EMMPRIN modulates the invasive phenotype and may be a potential therapeutic target.
authors: University of California, San Francisco, School of Dentistry, USA.
authors: Amanda
authors: A
authors: Siu
authors: University of California, San Francisco, School of Dentistry, USA.
authors: Joy
authors: J
authors: Chang
authors: University of California, Davis, USA.
authors: Casey
authors: C
authors: Lee
authors: University of California, San Francisco, School of Dentistry, USA.
authors: Stacey
authors: S
authors: Lee
authors: University of California, Irvine, USA.
authors: Carlin
authors: C
authors: Lee
authors: University of California, San Francisco, School of Dentistry, USA.
authors: Daniel M
authors: DM
authors: Ramos
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism*; D051926:Basigin / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D018920:Coculture Techniques; D058750:Epithelial-Mesenchymal Transition; D005347:Fibroblasts; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D039564:Integrin alphaV / Q000378:metabolism*; D016023:Integrins / Q000378:metabolism*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D014062:Tongue Neoplasms / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D039564:Integrin alphaV; D016023:Integrins; C073878:integrin alphavbeta6; D051926:Basigin