title: Design, synthesis, antiviral, and cytostatic evaluation of novel isoxazolidine analogues of C-nucleotides.
abstract: 5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations.
authors: a Bioorganic Chemistry Laboratory, Faculty of Pharmacy , Medical University of Łódź , Łódź , Poland.
authors: Magdalena
authors: M
authors: Grabkowska-Drużyc
authors: Jan
authors: J
authors: Balzarini
authors: Dorota G
authors: DG
authors: Piotrowska
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D061565:Cycloaddition Reaction; D054697:Cytostatic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004266:DNA Virus Infections / Q000188:drug therapy; D004267:DNA Viruses / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012327:RNA Virus Infections / Q000188:drug therapy; D012328:RNA Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D054697:Cytostatic Agents; D007555:Isoxazoles; D009711:Nucleotides; D063065:Organophosphonates