title: Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach.
abstract: Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian-Eulerian (ALE) approach was employed to handle the large mesh deformation induced by the beating ventricular wall and moving leaflets. Ventricular wall deformation was predefined based on MRI data, while leaflet dynamics were predicted numerically by fluid-structure interaction (FSI). Comparisons of simulation results with in vitro and in vivo measurements reported in the literature demonstrated that numerical method in combination with MRI was able to predict qualitatively the patient-specific intraventricular flow. To the best of our knowledge, we are the first to simulate patient-specific ventricular flow taking into account both mitral and aortic valves.
authors: Biofluid Mechanics Research Laboratory, 2 Engineering Drive 3, Department of Bioengineering, National University of Singapore, 117576 Singapore, Singapore; Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore.
authors: Boyang
authors: B
authors: Su
authors: Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore; Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore, Singapore. Electronic address: zhong.liang@nhcs.com.sg.
authors: Liang
authors: L
authors: Zhong
authors: Maritime Research Centre, Nanyang Technological University, Singapore.
authors: Xi-Kun
authors: XK
authors: Wang
authors: Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore.
authors: Jun-Mei
authors: JM
authors: Zhang
authors: Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, Singapore; Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore, Singapore.
authors: Ru San
authors: RS
authors: Tan
authors: Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore, Singapore.
authors: John Carson
authors: JC
authors: Allen
authors: School of Civil and Environmental Engineering, Nanyang Technological University, Singapore.
authors: Soon Keat
authors: SK
authors: Tan
authors: Department of Bioengineering, National University of Singapore, Singapore.
authors: Sangho
authors: S
authors: Kim
authors: Department of Bioengineering, National University of Singapore, Singapore.
authors: Hwa Liang
authors: HL
authors: Leo
mesh_terms: D001021:Aortic Valve / Q000033:anatomy & histology*; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008943:Mitral Valve / Q000033:anatomy & histology*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D008953:Models, Anatomic; D015233:Models, Statistical; D013599:Systole
keywords: CFD; FSI; Leaflet dynamics; Left ventricular flow