title: Therapeutic effect of mesenchymal multipotent stromal cells on memory in animals with Alzheimer-type neurodegeneration.
abstract: Transplantation of human mesenchymal multipotent stromal cells improved spatial memory in bulbectomized mice with Alzheimer-type neurodegeneration. The positive effect was observed in 1 month after intracerebral transplantation and in 3 months after systemic injection of mesenchymal multipotent stromal cells. No cases of malignant transformation were noted. These findings indicate prospects of using mesenchymal multipotent stromal cells for the therapy of Alzheimer disease and the possibility of their systemic administration for attaining the therapeutic effect.
authors: Institute of Cell Biophysics, Russian Academy of Science; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia. nbobkova@mail.ru.
authors: N V
authors: NV
authors: Bobkova
authors: R A
authors: RA
authors: Poltavtseva
authors: A N
authors: AN
authors: Samokhin
authors: G T
authors: GT
authors: Sukhikh
mesh_terms: D000544:Alzheimer Disease / Q000523:psychology / Q000628:therapy*; D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D018782:Maze Learning; D008568:Memory; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D021641:Recognition, Psychology