title: Cross-presentation by human dendritic cell subsets.
abstract: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets differ in their phenotype and functional properties, in particular in their ability to cross-present antigens (i.e. to present exogenous antigens on their MHC class I molecules). In humans, distinct DC subpopulations have also been identified but whether some human DC subsets are also specialized at cross-presentation remains debated. Here we review the DC subsets that have been identified in humans and we discuss recent work that addresses their ability to cross-present antigens and their efficiency for CD8(+) T cells activation.
authors: INSERM U932, 26 rue d'Ulm, 75005 Paris, France; Institut Curie, Section Recherche, 26 rue d'Ulm, 75005 Paris, France. Electronic address: elodie.segura@curie.fr.
authors: Elodie
authors: E
authors: Segura
authors: INSERM U932, 26 rue d'Ulm, 75005 Paris, France; Institut Curie, Section Recherche, 26 rue d'Ulm, 75005 Paris, France.
authors: Sebastian
authors: S
authors: Amigorena
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D005075:Biological Evolution; D002454:Cell Differentiation; D019070:Cell Lineage; D045142:Cross-Priming; D003713:Dendritic Cells / Q000276:immunology*; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice
chemical_list: D000941:Antigens
keywords: CD8+ T cells; Cross-presentation; Dendritic cells; Vaccination