title: Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal®) coated polypropylene mesh in rabbits.
abstract: OBJECTIVE
  To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal®) in contact with small bowel in an experimental model in rabbits.
  
  
  METHODS
  Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2 x 1 cm, in the right and left flanks. The right mesh was protected with Coseal® spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.
  
  
  RESULTS
  There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.
  
  
  CONCLUSIONS
  Polypropylene mesh coated with Coseal® showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.
authors: Reynaldo
authors: R
authors: Martins e Quinino
authors: Irami
authors: I
authors: Araújo-Filho
authors: Francisco Piganataro
authors: FP
authors: Lima
authors: André Luís Costa
authors: AL
authors: Barbosa
authors: Tatiana de Carvalho
authors: Tde C
authors: Maia
authors: Alberto
authors: A
authors: Goldenberg
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis / Q000473:pathology / Q000517:prevention & control; D005549:Foreign-Body Reaction / Q000473:pathology / Q000517:prevention & control; D046449:Hernia, Abdominal / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods; D010535:Laparoscopy; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011126:Polypropylenes / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D011817:Rabbits; D015203:Reproducibility of Results; D013526:Surgical Mesh / Q000009:adverse effects*; D013997:Time Factors; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D011126:Polypropylenes; D011092:Polyethylene Glycols; D003094:Collagen