title: Quantitative characterization of hepatocellular carcinoma and metastatic liver tumor by CT perfusion.
abstract: OBJECTIVE
  To evaluate the diagnostic value of computed tomography perfusion (CTP) in the distinction of hepatocellular carcinomas (HCCs) from metastatic liver tumors.
  
  
  METHODS
  CTP data from 90 liver tumors (HCC 38, metastasis 52) in 31 patients (16 men and 15 women; mean age 60.3 years) were studied. CTP was performed on a 16/64 multidetector-row CT scanner using a 30-s duration cine acquisition after rapid bolus injection (5-7 ml/s) of 50-70 ml of iodinated contrast medium. The CTP data were analyzed using a deconvolution model. Metastatic tumors were grouped into hypovascular (n = 36) and hypervascular (n = 16) tumors.
  
  
  CONCLUSIONS
  The hypovascular metastases showed a significantly lower blood flow (BF) and blood volume (BV), and higher mean transit time (MTT) than HCC (all P < 0.0001). BF, BV, and MTT of HCCs were substantially lower than those of hypervascular metastases (P = 0.02, P < 0.0001, P = 0.03, respectively). A receiver-operating characteristic analysis showed that BV was a useful marker to distinguish HCCs from hypervascular metastases.
authors: Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Koichi
authors: K
authors: Hayano
authors: Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Gaurav S
authors: GS
authors: Desai
authors: Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Avinash R
authors: AR
authors: Kambadakone
authors: Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Jorge M
authors: JM
authors: Fuentes
authors: Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Kenneth K
authors: KK
authors: Tanabe
authors: Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Dushyant V
authors: DV
authors: Sahani
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D055420:Perfusion Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*