title: Association of IL-6 polymorphisms with hepatocellular carcinoma risk: evidences from a meta-analysis.
abstract: The associations between IL-6 gene single nucleotide polymorphisms (SNPs) and risk of hepatocellular carcinoma (HCC) are controversial. We performed a meta-analysis to provide more credible evidence. We searched for relevant studies published up to 2013 by performing an efficient searching strategy. Odds ratios (OR) with 95% confidence interval (95% CI) was used to estimate the strength of the associations between IL-6 polymorphisms and HCC risk. We identified eight case-control studies involving 1,448 HCC cases and 3,160 controls. Our estimation specifically focused on two SNPs of the IL-6 gene, -174 G/C and -572 G/C. The combined results showed that association between IL-6-174 G/C polymorphism and risk of HCC was significant under additive model (CC vs. GG: OR 0.36; 95% CI, 0.16, 0.85) and recessive model (GG+CG vs. CC: OR 2.82; 95% CI 1.26, 6.28). However, the IL-6-572 G/C polymorphism was not associated with HCC risk. In conclusion, IL-6-174 G/C, but not -572 G/C polymorphism could be a candidate for susceptibility to HCC. However, the results should be cautiously interpreted due to the limited number of the included studies.
authors: Department of Oncology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, People's Republic of China.
authors: Ying
authors: Y
authors: Liu
authors: Su-jun
authors: SJ
authors: Gao
authors: Bo-xiang
authors: BX
authors: Du
authors: Jie-jun
authors: JJ
authors: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6