title: A study on the inhibitory effect of matrine on gastric cancer SGC-7901 cells.
abstract: The objective of this paper was to investigate the antitumour mechanism of action of matrine by studying its inhibitory effect on gastric cancer SGC-7901 cells. SGC-7901 cells were chosen, and cell-killing capacity of matrine on gastric cancer SGC-7901 cells was determined using MTT assay and single PI staining assay. The results showed that matrine had an inhibitory effect on gastric cancer SGC-7901 cells, which was somewhat dose-dependent. The study concluded that matrine has a significant in-vitro inhibitory effect on SGC-7901 tumour cells, influences cell cycle of SGC-7901 cells, and induces their apoptosis.
authors: Department of Oncology, Taihe Hospital Affiliated of Hubei University of Medicine, Shiyan 442000, China.
authors: Shimao
authors: S
authors: Song
authors: Shengming
authors: S
authors: Zhu
authors: Zhiguo
authors: Z
authors: Zhang
authors: Zhengying
authors: Z
authors: Mo
authors: Qing
authors: Q
authors: Ke
authors: Zhiguo
authors: Z
authors: Luo
mesh_terms: D000230:Adenocarcinoma; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008517:Phytotherapy; D011807:Quinolizines / Q000494:pharmacology*; D029909:Sophora; D013274:Stomach Neoplasms; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011807:Quinolizines; D000093842:Matrines
keywords: MTT assay; Matrine; SGC-7901