title: Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer.
abstract: BACKGROUND
  Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors.
  
  
  METHODS
  The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type.
  
  
  RESULTS
  Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p<0.0001). The Kruskal-Wallis test showed an association of increased expression of MCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247).
  
  
  CONCLUSIONS
  Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered.
authors: Department of Histology and Embryology, Wroclaw Medical University, Chalubinskiego 6a, 50-368 Wroclaw, Poland. piotr.dziegiel@umed.wroc.pl.
authors: Christopher
authors: C
authors: Kobierzycki
authors: Bartosz
authors: B
authors: Pula
authors: Mateusz
authors: M
authors: Skiba
authors: Karolina
authors: K
authors: Jablonska
authors: Krzysztof
authors: K
authors: Latkowski
authors: Maciej
authors: M
authors: Zabel
authors: Ewa
authors: E
authors: Nowak-Markwitz
authors: Marek
authors: M
authors: Spaczynski
authors: Witold
authors: W
authors: Kedzia
authors: Marzena
authors: M
authors: Podhorska-Okolow
authors: Piotr
authors: P
authors: Dziegiel
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D008668:Metallothionein / Q000378:metabolism*; D008875:Middle Aged; D064110:Minichromosome Maintenance Proteins / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D008668:Metallothionein; D064110:Minichromosome Maintenance Proteins
keywords: Metallothionein; minichromosome maintenance protein; ovarian cancer