title: Leptin in chronic kidney disease: a link between hematopoiesis, bone metabolism, and nutrition.
abstract: Anemia, dyslipidemia, malnutrition, together with mineral and bone disorders are common complications in patients with chronic kidney disease (CKD). All are associated with increased risk of mortality. Leptin is a small peptide hormone that is mainly but not exclusively produced in adipose tissue. It is also secreted by normal human osteoblasts, subchondral osteoblasts, placental syncytiotrophoblasts, and the gastric epithelium. Leptin binds to its receptors in the hypothalamus to regulate bone metabolism and food intake. Leptin also has several other important metabolic effects on peripheral tissues, including the liver, skeletal muscle, and bone marrow. Leptin is cleared principally by the kidney. Not surprisingly, serum leptin appears to increase concurrently with declines in the glomerular filtration rate in patients with CKD. A growing body of evidence suggests that leptin might be closely related to hematopoiesis, nutrition, and bone metabolism in CKD patients. Results are conflicting regarding leptin in patients with CKD, in whom both beneficial and detrimental effects on uremia outcome are found. This review elucidates the discovery of leptin and its receptors, changes in serum or plasma leptin levels, the functions of leptin, relationships between leptin and the complications mentioned above, and pharmaceutical interventions in serum leptin levels in patients with CKD.
authors: Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, People's Republic of China.
authors: Jingjing
authors: J
authors: Zhang
authors: Ningning
authors: N
authors: Wang
mesh_terms: D000740:Anemia / Q000209:etiology; D001851:Bone Diseases, Metabolic / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D050171:Dyslipidemias / Q000209:etiology; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000097:blood*; D044342:Malnutrition / Q000209:etiology; D009752:Nutritional Status / Q000502:physiology*; D054411:Receptors, Leptin / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications
chemical_list: D020738:Leptin; D054411:Receptors, Leptin