title: [Intra-arterial treatment of ischemic stroke--still no evidence but reason for further study].
abstract: In 3 recent randomized controlled trials of intra-arterial treatment of acute ischemic stroke - IMS-III, SYNTHESIS and MR RESCUE - intra-arterial treatment increased the proportion of patients with recanalization and the treatment appeared safe. However, the trials did not show an effect on functional recovery, although a substantial effect could not be excluded. The delay between onset of symptoms and treatment was long, and stent retrievers were used in only a few patients. In our view, a rational and ethical approach would now be to treat quickly with IV rtPA and when possible, refer and include in new randomized clinical trials that compare intra-arterial treatment with standard care, such as MR CLEAN or BASICS in the Netherlands.
authors: *Mede namens de Sectie Neuroradiologie van de Nederlandse Vereniging voor Radiologie, de Kerncommissie van het Nederlands Neurovasculair Genootschap, het Nederlands Genootschap voor Interventie Radiologie en de Nederlandse Neurovasculaire Werkgroep.
authors: Diederik W J
authors: DW
authors: Dippel
authors: Jelis
authors: J
authors: Boiten
authors: Jan Albert
authors: JA
authors: Vos
authors: Charles B M
authors: CB
authors: Majoie
mesh_terms: D019317:Evidence-Based Medicine; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007269:Injections, Intra-Arterial; D009426:Netherlands; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator