title: Effect of peritoneal dialysis modality on the 1-year rate of decline of residual renal function.
abstract: OBJECTIVE
  The effect of different peritoneal dialysis (PD) modalities on the decline in residual renal function (RRF) is unclear due to inconsistencies among studies. In particular, the effect of automated peritoneal dialysis (APD) modalities [continuous cyclic peritoneal dialysis (CCPD) and nightly intermittent peritoneal dialysis (NIPD)] on RRF has not been examined in a large cohort.
  
  
  METHODS
  We conducted a single-center retrospective study to investigate the association between PD modalities and decline in RRF in 142 incident PD patients [34 on CCPD, 36 on NIPD, and 72 on continuous ambulatory peritoneal dialysis (CAPD)]. RRF was measured within 2 months from PD start and at 1 year after PD initiation.
  
  
  RESULTS
  The RRF at 1 year after PD initiation was 1.98±2.20 mL/min/1.73 m² in CCPD patients and 3.63±3.67 mL/min/1.73 m² in NIPD patients, which were moderately lower than 4.23±3.51 mL/min/1.73 m² in CAPD patients (p=0.064). Moreover, there was no significant difference in the 1-year rate of decline of RRF between CCPD and NIPD patients, although APD patients had a faster 1-year RRF decline rate than CAPD patients (CCPD and NIPD vs. CAPD: -45.68 and -36.69 vs. 1.17%/year, p=0.045). APD was associated with a more rapid decline in RRF in patients with end-stage renal disease undergoing PD, although multivariate analysis attenuated the significance of this finding (β=-31.50; 95% CI, -63.61 to 0.62; p=0.052).
  
  
  CONCLUSIONS
  Our results suggest that CAPD might be more helpful than APD for preserving RRF during the first year of dialysis therapy, although there was no significant difference in the 1-year rate of decline of RRF between the two APD modalities.
authors: Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. khchoi6@yuhs.ac.
authors: Chan Ho
authors: CH
authors: Kim
authors: Hyung Jung
authors: HJ
authors: Oh
authors: Mi Jung
authors: MJ
authors: Lee
authors: Young Eun
authors: YE
authors: Kwon
authors: Yung Ly
authors: YL
authors: Kim
authors: Ki Heon
authors: KH
authors: Nam
authors: Kyoung Sook
authors: KS
authors: Park
authors: Seong Yeong
authors: SY
authors: An
authors: Kwang Il
authors: KI
authors: Ko
authors: Hyang Mo
authors: HM
authors: Koo
authors: Fa Mee
authors: FM
authors: Doh
authors: Seung Hyeok
authors: SH
authors: Han
authors: Tae-Hyun
authors: TH
authors: Yoo
authors: Beom Seok
authors: BS
authors: Kim
authors: Shin-Wook
authors: SW
authors: Kang
authors: Kyu Hun
authors: KH
authors: Choi
mesh_terms: D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies
keywords: Continuous ambulatory peritoneal dialysis; end-stage kidney disease; glomerular filtration rate; peritoneal dialysis