title: Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways.
abstract: BACKGROUND
  There is an association between thyroid disorders and diabetes mellitus.
  
  
  OBJECTIVE
  To investigate thyroid hormone levels in different glucose metabolic statuses, analyse relationships between thyroid hormone levels and different categories of prediabetes and metabolic parameters within a large euthyroid nondiabetic population.
  
  
  METHODS
  A total of 3328 subjects without diabetes or thyroid dysfunction were included in this cross-sectional study. Subjects were divided in to four groups [normal glucose tolerance (NGR), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI)] according to the results of oral glucose tolerance test. Participants were then divided into four groups according to the quartile of free T3 (FT3) in their blood.
  
  
  RESULTS
  Subjects with IFG had higher levels of FT3 and ratio of FT3 to FT4 (FT3/FT4), but lower level of free T4 (FT4) than subjects with IGT. FT3/FT4 was negatively associated with postprandial plasma glucose (PPG) [standardized β (β) = -0·087; P < 0·001]. The prevalence of IFG and CGI was increased with the level of FT3, while the prevalence of IGT was decreased with the level of FT3 (P for trend: <0·001, 0·003 and <0·001, respectively). FT3 was negatively associated with the risk of IGT (OR = 0·409, 95% CI 0·179-0·935), whereas FT4 was positively associated with the risk of IGT (OR = 1·296, 95% CI 1·004-1·673).
  
  
  CONCLUSIONS
  Free thyroid hormone levels were different between subjects with IFG and IGT. FT3 affects the prevalence of IFG and IGT in opposite ways. The difference in thyroid hormone levels may play an important role in the different pathological mechanisms of IFG and IGT.
authors: Department of Endocrinology and Metabolism, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Su
authors: S
authors: Jing
authors: Ding
authors: D
authors: Xiaoying
authors: Xu
authors: X
authors: Ying
authors: Liu
authors: L
authors: Rui
authors: Gu
authors: G
authors: Mingyu
authors: Chen
authors: C
authors: Yuting
authors: Yin
authors: Y
authors: Yanhua
authors: Wang
authors: W
authors: Yufan
authors: Sun
authors: S
authors: Haiyan
authors: Peng
authors: P
authors: Yongde
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D013959:Thyroid Diseases / Q000097:blood* / Q000150:complications; D013961:Thyroid Gland / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D001786:Blood Glucose; D013963:Thyroid Hormones; D014284:Triiodothyronine