title: Serum levels of osteopontin as a prognostic factor in patients with oral squamous cell carcinoma.
abstract: Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this study was to determine osteopontin serum levels in patients with oral squamous cell carcinoma (OSCC) and investigated its correlation with clinicopathological features of tumor. Using an ELISA kit, we assessed and compared the circulating levels of OPN in blood serum of 45 oral squamous cell carcinoma patients with 45 healthy control samples. The serum osteopontin level in patients with OSCC was significantly higher (145.8 ± 14.6 ng/ml, n = 45) compared with the healthy controls (53.9 ± 9.6 ng/ml, n = 45, p < 0.001). Mean serum osteopontin level was significantly higher in patients with nodal metastasis (p = 0.03) and higher stage (p = 0.02). Findings of the present study suggest that OPN may have a potential role in pathogenesis of OSCC and it may be used as a tool for monitoring tumor progression.
authors: Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Maryam
authors: M
authors: Mardani
authors: Azadeh
authors: A
authors: Andisheh-Tadbir
authors: Bijan
authors: B
authors: Khademi
authors: Mohammad Javad
authors: MJ
authors: Fattahi
authors: Shapour
authors: S
authors: Shafiee
authors: Maryam
authors: M
authors: Asad-Zadeh
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000209:etiology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000209:etiology / Q000473:pathology*; D053495:Osteopontin / Q000097:blood / Q000502:physiology*; D011379:Prognosis
chemical_list: D053495:Osteopontin