title: Innate immune cells in transplantation.
abstract: OBJECTIVE
  To examine the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets.
  
  
  RESULTS
  Current research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system.
  
  
  CONCLUSIONS
  This review highlights the new therapeutic targets in the innate immune system that may be useful in the treatment of transplant recipients. It also emphasizes the need to use caution in exploring these new therapeutics.
authors: aDepartment of Surgery bDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors: Jessica H
authors: JH
authors: Spahn
authors: Wenjun
authors: W
authors: Li
authors: Daniel
authors: D
authors: Kreisel
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D014181:Transplantation Immunology