title: Fully automated biometry of in situ intraocular lenses using long scan depth spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  Spectral-domain optical coherence tomography (SD-OCT) was used to automatically measure accommodative biometric changes in the anterior segment of eyes implanted with an intraocular lens (IOL). The repeatability and reliability of the automated measurements were also evaluated.
  
  
  METHODS
  Long scan depth SD-OCT was used to image the anterior segment of eyes implanted with IOLs. A fully automated algorithm was used to detect the boundaries of the cornea and IOL and yielded the measurements. The results included anterior segment dimensions in IOL eyes and the deflection of the IOLs. Automated measurements were validated in vitro and compared with the manual results in vivo on 15 cross-sectional images from patients with IOLs. Five eyes with five different types of IOLs, respectively, were enrolled to test the repeatability of the automated measurements during accommodation.
  
  
  RESULTS
  Intraocular lens central thickness and anterior and posterior curvature radii measured by long scan depth SD-OCT in vitro and in a model eye matched well with those determined by a micrometer caliper and interferometer. In vivo, there was good correlation of the biometric data determined by automated and manual segmentations (P<0.05, r-value range: 0.635-0.997). There were no significant differences for any variable between the two measurements at each accommodative state (P>0.05). Anterior chamber depth and pupil diameter showed significant changes between the nonaccommodative and 2.5-D accommodative states (P<0.05), whereas the shape of the IOLs did not change significantly (P>0.05).
  
  
  CONCLUSIONS
  The long scan depth SD-OCT with the automated algorithm was verified to have a great potential in studying accommodative biometric changes of the anterior segment in eyes with IOLs and IOL deflections.
authors: School of Ophthalmology and Optometry (Q.C., L.L., D.Z., Y.W., Y.S., F.L., M.S.), Wenzhou Medical University, Wenzhou, Zhejiang, China; and Department of Ophthalmology (J.W.), Bascom Palmer Eye Institute, University of Miami, Miami, FL.
authors: Qi
authors: Q
authors: Chen
authors: Lin
authors: L
authors: Leng
authors: Dexi
authors: D
authors: Zhu
authors: Yaozeng
authors: Y
authors: Wang
authors: Yilei
authors: Y
authors: Shao
authors: Jianhua
authors: J
authors: Wang
authors: Fan
authors: F
authors: Lu
authors: Meixiao
authors: M
authors: Shen
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000368:Aged; D000465:Algorithms; D000869:Anterior Eye Segment / Q000033:anatomy & histology*; D001699:Biometry / Q000379:methods*; D003315:Cornea / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011680:Pupil / Q000502:physiology; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods