title: Effect of pravastatin on echocardiographic circulation parameters in dogs.
abstract: The purpose of this study was to determine the effect of pravastatin (PS) on hemodynamic parameters in healthy dogs. Five beagle dogs were repeatedly used in each of the 4 groups. One group was not medicated (control). Dogs in other groups received 0.5, 1.0 or 2.0 mg/kg PS orally q24hr, for 4 weeks. Physical examination, blood biochemical tests, blood pressure measurements and Doppler echocardiography were performed before and 1, 2 and 4 weeks after PS administration in all dogs. PS significantly reduced the left atrial-to-aortic diameter ratio (LA/Ao), early diastolic transmitral flow (E) wave, E/early diastolic mitral annulus motion velocity (Em) ratio, left ventricular (LV) fractional shortening, LV ejection fraction, mid systolic myocardial velocity gradient, stroke volume (SV), cardiac output (CO), right and left ventricular Tei indices and elevated Em and early diastolic myocardial velocity gradient. Heart rate was not significantly altered during PS administration, but mean blood pressure decreased slightly. The hematological and blood biochemical values were within normal limits during PS administration. These results revealed that PS administration increases LV expansion capacity and decreases LV constriction and left atrial pressure. It has been suggested that PS may be effective in improving heart failures with LV diastolic dysfunction or elevated left atrial pressure in dogs.
authors: Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan.
authors: Shinji
authors: S
authors: Arita
authors: Noboru
authors: N
authors: Arita
authors: Yoshiaki
authors: Y
authors: Hikasa
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000187:drug effects; D001774:Blood Chemical Analysis / Q000662:veterinary; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015150:Echocardiography, Doppler / Q000662:veterinary; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D017035:Pravastatin / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors
chemical_list: D017035:Pravastatin