title: Uterine volume and endometrial thickness in the early follicular phase in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  We aimed to evaluate uterine volume and endometrial thickness during the early follicular phase in patients with polycystic ovary syndrome (PCOS) and healthy controls.
  
  
  METHODS
  We studied 1,016 PCOS patients and 182 healthy controls. The anthropometric, endocrine, and metabolic characteristics of PCOS were determined. Uterine volume and endometrial thickness were also recorded.
  
  
  RESULTS
  Uterine volume progressively increased with age both in PCOS patients and controls. Patients with PCOS and body mass index (BMI) ≥25 kg/m2 had greater uterine volumes than PCOS patients with BMI <25 kg/m2 (P<.001). Patients with the classic PCOS phenotypes (i.e., with oligo-ovulation and/or anovulation [ANOV] and hyperandrogenemia [HA] with or without polycystic ovaries [PCO]) had smaller uterine volume than PCOS patients with the additional phenotypes introduced by the Rotterdam criteria (i.e., with PCO and either ANOV or HA; P = .033) and controls (P = .045).
  
  
  CONCLUSIONS
  Uterine volume increases progressively with age and obesity in PCOS patients. The smaller uterine volumes and endometrial thicknesses in the classic PCOS phenotypes might be attributed to the more severe HA of these patients.
authors: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Dimitrios
authors: D
authors: Panidis
authors: First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Konstantinos
authors: K
authors: Tziomalos
authors: Third Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Efstathios
authors: E
authors: Papadakis
authors: Third Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Christos
authors: C
authors: Vosnakis
authors: Third Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Georgios
authors: G
authors: Betsas
authors: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Ekaterini
authors: E
authors: Tsourdi
authors: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Ilias
authors: I
authors: Katsikis
mesh_terms: D000328:Adult; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005498:Follicular Phase / Q000502:physiology*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000473:pathology*; D011446:Prospective Studies; D014599:Uterus / Q000473:pathology*