title: Experimental model of cutaneous radiation injury in rabbits.
abstract: OBJECTIVE
  To describe an experimental model of cutaneous radiation injury in rabbits.
  
  
  METHODS
  On this study eight six-month-old New Zealand male rabbits, with an average weight of 2.5 kg were used. They were distributed in four groups (n=2 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 2000, 3000 and 4500 cGy, respectively. Photographic analysis and histopathological evaluation of the irradiated areas were carried out.
  
  
  RESULTS
  After 30 days, the animals from the control group had all their hair grown. In spite of that, the animals from group 2000 cGy had a 60-day alopecia and from group 3000 cGy, a 90-day alopecia. After the 30th day, the 3000 cGy group demonstrated 90-day cutaneous radiation injuries, graded 3 and 4. One of the animals from group 4500 cGy died on the 7th day with visceral necrosis. The other from the same group had total skin necrosis. A progressive reduction of glands and blood vessels count and an increase on collagen deposition was observed.
  
  
  CONCLUSIONS
  The proposed experimental model is reproductable. This study suggests that the dosage 4500 cGy is excessive and the 3000 cGy is the most effective for this experimental model of cutaneous radiation injury in rabbits.
authors: Rafael Panisi de Campos
authors: RP
authors: Meirelles
authors: Bernardo
authors: B
authors: Hochman
authors: Americo
authors: A
authors: Helene Junior
authors: Rute
authors: R
authors: Lellis
authors: Murillo Francisco Pires
authors: MF
authors: Fraga
authors: Lydia Masako
authors: LM
authors: Ferreira
mesh_terms: D000505:Alopecia / Q000209:etiology; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009336:Necrosis; D011817:Rabbits; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology; D015203:Reproducibility of Results; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology; D013997:Time Factors