title: Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives.
abstract: A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.
authors: Department of Chemistry, Manipal Institute of Technology, Manipal University, 576 104, India.
authors: B
authors: B
authors: Chandrakantha
authors: Medicinal Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, Karnataka, India. Electronic address: isloor@yahoo.com.
authors: Arun M
authors: AM
authors: Isloor
authors: Department of Printing and Media Engineering, Manipal Institute of Technology, Manipal University, 576 104, India.
authors: Prakash
authors: P
authors: Shetty
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors: Hoong Kun
authors: HK
authors: Fun
authors: Faculty of Industrial Science and Technology, Universiti Malaysia Pahang, Gambang, Kuantan 26300, Pahang Darul Makmur, Malaysia.
authors: Gurumurthy
authors: G
authors: Hegde
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole
keywords: 1,3,4-Thiadiazole; 2,6-Diaryl imidazo [2,1-b] [1,3,4] thiadiazole; Antibacterial; Antifungal activity