title: APOE gene polymorphisms and susceptibility to Creutzfeldt-Jakob disease.
abstract: Associations between apolipoprotein E (APOE) gene polymorphisms and Creutzfeldt-Jakob disease (CJD) have been reported, but the results from many of these studies are conflicting. To investigate the association between APOE polymorphisms and CJD risk, we performed a meta-analysis. We used odds ratios (OR) with 95% confidence intervals (CI) to assess the strength of the association. The frequency of putative risk alleles in control subjects was estimated with the Mantel-Haenszel method. Cochran's Q statistic and the inconsistency index (I(2)) were used to test heterogeneity. Egger's test and an inverted funnel plot were used to assess bias. Our study included 11 published case-control studies with APOE genotyping, involving a total of 1001 CJD patients and 1211 controls. Overall, the APOE 34 (OR 1.37, 95% CI: 1.09-1.72), and APOE 44 (OR 3.16, 95% CI: 1.37-7.26) genotypes and the APOE 4 (OR 1.41, 95% CI: 1.08-1.85) allele were associated with an increased risk of CJD, and the APOE 33 (OR 0.81, 95% CI: 0.67-0.97) genotype tended to protect against CJD. However, we did not find significant evidence supporting associations of the APOE 22 (OR 1.15, 95% CI: 0.45-2.93), APOE 23 (OR 0.84, 95% CI: 0.64-1.09), or APOE 24 (OR 1.40, 95% CI: 0.70-2.77) genotypes, nor the APOE 2 (OR 1.02, 95% CI: 0.73-1.42) or APOE 3 (OR 0.82, 95% CI: 0.65-1.02) alleles with CJD using a fixed-effects model. Our results support a genetic association between APOE polymorphisms and CJD.
authors: Department of Neurology, First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning 530021, Guangxi, China.
authors: Yunfei
authors: Y
authors: Wei
authors: Department of Neurology, First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning 530021, Guangxi, China.
authors: Yanyan
authors: Y
authors: Tang
authors: Department of Cardiothoracic Surgery, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, China.
authors: Wenwu
authors: W
authors: He
authors: Department of Neurology, First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning 530021, Guangxi, China.
authors: Zhanli
authors: Z
authors: Qu
authors: Department of Anesthesiology, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, China.
authors: Jinming
authors: J
authors: Zeng
authors: Department of Neurology, First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning 530021, Guangxi, China. Electronic address: Mdqc6639@126.com.
authors: Chao
authors: C
authors: Qin
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D001057:Apolipoproteins E
keywords: APOE; Apolipoprotein E; Creutzfeldt–Jakob disease; Meta-analysis; Polymorphism