title: The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients.
abstract: Schizophrenia is characterized by a wide spectrum of clinical manifestations, including strong effects on mood and behavior. Patients can also suffer from serious comorbidities including immune system or metabolic abnormalities. Recent advances using proteomic profiling approaches have increased our understanding of these molecular effects and have laid the groundwork for unraveling the heterogeneity of this broadly defined disease. These findings could lead to improved diagnosis and stratification of patients through identification of biochemically different disease subtypes and personalized medicine approaches. The inclusion of molecular signatures in psychiatry will be an important leap forward in providing more effective treatment of patients suffering from this debilitating disorder.
authors: Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK.
authors: Paul C
authors: PC
authors: Guest
authors: Man K
authors: MK
authors: Chan
authors: Michael G
authors: MG
authors: Gottschalk
authors: Sabine
authors: S
authors: Bahn
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D018384:Oxidative Stress; D057285:Precision Medicine; D040901:Proteomics; D012559:Schizophrenia / Q000175:diagnosis*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers