title: [Valproate-induced hyperammonemic encephalopathy in a neonate: treatment with carglumic acid].
abstract: Valproate-induced hyperammonemic encephalopathy (VHE) is an unusual and serious complication of valproate (VA) treatment. When an early diagnosis is made, it can be reversed with VA withdrawal and early treatment for hyperammonemia. We describe the case of a 20 days old male, who developed a serious VHE after receiving VA for refractory neonatal seizures. The VHE was resolved with VA withdrawal in association with carglumic acid and other measures for hyperammonemia treatment.
authors: Servicio de Neonatología, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España. Electronic address: bcolomer@gmail.com.
authors: B
authors: B
authors: Fernández Colomer
authors: AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: S
authors: S
authors: Rekarte García
authors: Servicio de Neonatología, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: J E
authors: JE
authors: García López
authors: AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: C
authors: C
authors: Pérez González
authors: AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: M
authors: M
authors: Montes Granda
authors: Servicio de Neonatología, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: G D
authors: GD
authors: Coto Cotallo
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D005971:Glutamates / Q000627:therapeutic use*; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced* / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000209:etiology*; D012640:Seizures / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D005971:Glutamates; C528449:carglumic acid; D014635:Valproic Acid
keywords: Adverse effect; Carglumic acid; Efecto adverso; Hiperamoniemia; Hyperammonemia; Infant; Neonato; Newborn; Valproate; Valproico; Ácido carglúmico ;