title: Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  Adiponectin receptor 1 (ADIPOR1) is an identified receptor for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. The ADIPOR1 gene is a potential candidate gene in polycystic ovary syndrome (PCOS). The aim of this study is to assess the association between single-nucleotide polymorphism (SNP) rs1539355 in the ADIPOR1 gene and PCOS in Chinese women.
  
  
  METHODS
  302 patients with PCOS and 312 healthy controls were included in this study. The ADIPOR1 genotype distribution was detected using the polymerase chain reaction melting temperature shift method.
  
  
  RESULTS
  The genotypic distributions of SNP rs1539355 did not differ in patients with PCOS compared to controls. However, the frequency of the G allele in the PCOS group was significantly higher than that in the control group (p = 0.037). Patients with the AG or GG genotype had a higher homeostasis model assessment for insulin resistance (HOMA-IR) (p < 0.05) compared to patients with the AA genotype. The fasting insulin levels in subjects with the GG genotype were significantly higher than those in patients with the AA genotype (p < 0.05).
  
  
  CONCLUSIONS
  SNP rs1539355 in the ADIPOR1 gene is associated with insulin resistance in Chinese PCOS patients.
authors: Department of Gynecological Ultrasound, Affiliated Hospital of Qingdao University Medical College, Qingdao, PR China.
authors: Zongli
authors: Z
authors: Yang
authors: Xiaojv
authors: X
authors: Yang
authors: Jine
authors: J
authors: Xu
authors: Yongmei
authors: Y
authors: Sun
authors: Yuhua
authors: Y
authors: Shi
authors: Shibao
authors: S
authors: Fang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: C475418:ADIPOR1 protein, human; D054419:Receptors, Adiponectin; D004247:DNA