title: Murine b7-h3 is a co-stimulatory molecule for T cell activation.
abstract: The B7 family member B7-H3 (CD276) plays a key role during an immune response but its function remains controversial. In this study, we found that murine B7-H3 up-regulated the proliferation and cytokine production of T cells. Our study suggested that there was no interaction of murine B7-H3 with a triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2). Further studies demonstrated that mouse B7-H3 specifically bound to T cells and its receptor was not murine TLT-2. Moreover, murine B7-H3 was a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
authors: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University , Suzhou, China .
authors: Ruhong
authors: R
authors: Yan
authors: Shun
authors: S
authors: Yang
authors: Aiping
authors: A
authors: Gu
authors: Fuqin
authors: F
authors: Zhan
authors: Chunyan
authors: C
authors: He
authors: Chenhao
authors: C
authors: Qin
authors: Xueguang
authors: X
authors: Zhang
authors: Ping
authors: P
authors: Feng
mesh_terms: D000818:Animals; D060887:B7 Antigens / Q000502:physiology*; D016466:CHO Cells; D049109:Cell Proliferation; D006224:Cricetinae; D003412:Cricetulus; D016207:Cytokines / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D060887:B7 Antigens; C486038:Cd276 protein, mouse; D016207:Cytokines; D011948:Receptors, Antigen, T-Cell