title: [Surgical treatment of primary hyperparathyroidism].
abstract: OBJECTIVE
  To investigate the causes of misdiagnosis and the surgical treatment of primary hyperparathyroidism (PHPT).
  
  
  METHODS
  The clinical data of 26 patients with PHPT from July 2008 to January 2013 in The Affiliated Hospital of Chengde Medical College and The Fourth Hospital of Hebei Medical University were retrospectively analyzed, including preoperative diagnosis and operative method. The level of serum calciumion and serum parathyroid hormone (PTH), Ultrasonography, CT, (99)mTc-methoxy isobutylis onitrile ((99)mTc-MIBI) were used in the diagnosis before operation. All patients accepted surgical treatment after the level of serum calciumion decreased to normal.
  
  
  RESULTS
  The level of PTH was examined 10 min after resection, which declined more than 50%. After pathological examination, 23 cases were diagnosed as parathyroid adenoma, 2 cases were parathyroid hyperplasia, and 1 case was parathyroid carcinoma. The level of serum calciumion and serum parathyroid hormone were returned to the normal level after operation. All patients recovered with no postoperative complication.Followed up lasted from 6 months to 5 years, no case recurred.Sixteen cases with symptoms experienced significant improvement in signs, including 10 cases with clinical symptoms completely disappeared.
  
  
  CONCLUSIONS
  The test of serum calciumion and serum PTH, Ultrasonography, CT, (99)mTc-MIBI are helpful to reduce the misdiagnose rate of primary hyperparathyroidism before operation. The examination of serum parathyroid hormone in operation is helpful to reduce the operation range and time.
authors: Department of Otorhinolaryngology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.
authors: Shan
authors: S
authors: Gao
authors: Department of Otorhinolaryngology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050051, China. Email: zhruili@126.com.
authors: Rui-Li
authors: RL
authors: Zhao
authors: Qin
authors: Q
authors: Xu
authors: Shu-Jun
authors: SJ
authors: Zhang
authors: Ai-Hui
authors: AH
authors: Wang
authors: Pei-Ming
authors: PM
authors: Feng
authors: Zhi-Xin
authors: ZX
authors: Cui
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D006801:Humans; D049950:Hyperparathyroidism, Primary; D009364:Neoplasm Recurrence, Local; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000601:surgery
chemical_list: D010281:Parathyroid Hormone