title: ⁶⁸Ga-DOTATOC PET-CT in the localization of source of ectopic ACTH in patients with ectopic ACTH-dependent Cushing's syndrome.
abstract: Localization of the source of adrenocorticotrophic hormone (ACTH) in ectopic ACTH-induced Cushing's syndrome is of paramount importance as definitive management mainly involves surgical resection of tumor. Many of these are occult, not identified by conventional structural imaging. Accurate localization and assessment of their functional status has become feasible with the use positron emission tomography-computerized tomography using (68)Ga-DOTATOC (1,4,7,10-tetraazacy-clododecane-NI,NII,NIII,NIIII-tetraacetic acid(D)-Phe1-thy3-octreotide), aiding in proper planning for their definitive management.
authors: Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
authors: Balasubramanian
authors: B
authors: Venkitaraman
authors: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors: Sellam
authors: S
authors: Karunanithi
authors: Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
authors: Arvind
authors: A
authors: Kumar
authors: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors: Chandrasekhar
authors: C
authors: Bal
authors: Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
authors: Ariachery C
authors: AC
authors: Ammini
authors: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: rkphulia@yahoo.com.
authors: Rakesh
authors: R
authors: Kumar
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000000981:diagnostic imaging*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D003480:Cushing Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging; D015282:Octreotide / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D000324:Adrenocorticotropic Hormone; D015282:Octreotide
keywords: (68)Ga-DOTATOC; Ectopic ACTH-dependent Cushing's syndrome; Neuroendocrine tumors; PET-CT