title: Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4 and Fe3O4 metal cores.
abstract: Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.
authors: Department of Biomedical Engineering, Technological Educational Institute of Athens, Agiou Spiridonos 28, 12210, Egaleo, Greece. Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, N.C.S.R. 'Demokritos', 15310, Agia Paraskevi, Greece.
authors: D
authors: D
authors: Psimadas
authors: G
authors: G
authors: Baldi
authors: C
authors: C
authors: Ravagli
authors: M
authors: M
authors: Comes Franchini
authors: E
authors: E
authors: Locatelli
authors: C
authors: C
authors: Innocenti
authors: C
authors: C
authors: Sangregorio
authors: G
authors: G
authors: Loudos
mesh_terms: D000818:Animals; D003035:Cobalt / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000493:pharmacokinetics; D049669:History, 16th Century; D006801:Humans; D006979:Hyperthermia, Induced; D007553:Isotope Labeling; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D019275:Radiopharmaceuticals; D014018:Tissue Distribution
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D019275:Radiopharmaceuticals; D003035:Cobalt; D052203:Ferrosoferric Oxide