title: [The effect of tanshinone II A on the transmembrance action potential of myocardial cells in LQT2 rabbit models].
abstract: OBJECTIVE
  To determine the effect of tanshinone II A on the transmembrance action potential of three layers of myocardial cells in LQT2 rabbit models.
  
  
  METHODS
  Whole-cell patch clamp technique was used to record the action potential duration 90 (APD90) and the transmural dispersion of repolarization (TDR) of the epicardium, mid-myocardium and endocardium in the LQT2 rabbits.
  
  
  RESULTS
  Of the three layers of myocardial cells, the mid-myocardium had the longest APD90 and the epicardium had the shortest APD90. The APD90 of all three layers of myocardial cells were shortened with infusion of 10 mg/mL tanshinone II A. Their TDR values also reduced by the infusion.
  
  
  CONCLUSIONS
  Tanshinone II A shortens APD90 and reduces TDR values.
authors: Department of Cardiovascular, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
authors: Ling
authors: L
authors: Liang
authors: Qiang
authors: Q
authors: Xie
authors: Wei-Hua
authors: WH
authors: Li
authors: Zhi
authors: Z
authors: Zeng
authors: Zheng-Rong
authors: ZR
authors: Huang
authors: De-long
authors: DL
authors: Li
mesh_terms: D045784:Abietanes / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D005260:Female; D008133:Long QT Syndrome / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology*; D011817:Rabbits
chemical_list: D045784:Abietanes; C021751:tanshinone