title: Dasatinib-induced haemorrhagic colitis in chronic myeloid leukaemia (CML) in blast crisis.
abstract: We report a rare case of haemorrhagic colitis attributed to dasatinib therapy in a 47-year-old African-American woman who was diagnosed with extramedullary T-lymphoblastic transformation of chronic myeloid leukaemia. The patient received intensive chemotherapy and dasatinib 100 mg/day. After achieving complete cytogenetic and major molecular response after 9 months of therapy, she developed bloody diarrhoea and pancytopenia. Colonoscopy showed inflammation of the descending colon and histopathology revealed patchy increase in intraepithelial lymphocytes. Dasatinib was stopped with prompt resolution of diarrhoea. The current literature suggests that there is an association in a subset of patients on dasatinib between clonal T-cell lymphocytosis in the peripheral blood and developing colitis and pleural effusions. These patients had a good response to dasatinib as did our patient. Our patient illustrates a unique disease presentation along with a rare drug adverse event.
authors: Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA.
authors: Mohammad Muhsin
authors: MM
authors: Chisti
authors: Amine
authors: A
authors: Khachani
authors: Govinda R
authors: GR
authors: Brahmanday
authors: Justin
authors: J
authors: Klamerus
mesh_terms: D001752:Blast Crisis / Q000188:drug therapy; D003092:Colitis / Q000139:chemically induced*; D044683:Colon, Descending; D000069439:Dasatinib; D003937:Diagnosis, Differential; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D000069439:Dasatinib