title: Lessons from ECLIPSE: a review of COPD biomarkers.
abstract: The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.
authors: Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain.
authors: Rosa
authors: R
authors: Faner
authors: GlaxoSmithKline Research and Development, King of Prussia, Pennsylvania, USA.
authors: Ruth
authors: R
authors: Tal-Singer
authors: GlaxoSmithKline Research and Development, Stevenage, UK.
authors: John H
authors: JH
authors: Riley
authors: Channing Division of Network Medicine and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors: Bartolomé
authors: B
authors: Celli
authors: Department of Respiratory Medicine, Odense University Hospital, and Clinical Institute, University of Southern Denmark, Odense, Denmark Respiratory and Allergy Research Group, Manchester Academic Health Sciences Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.
authors: Jørgen
authors: J
authors: Vestbo
authors: University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.
authors: William
authors: W
authors: MacNee
authors: Department of Thoracic Medicine, Institute of Clinical Science, University of Bergen, Haukeland University Hospital, Bergen, Norway.
authors: Per
authors: P
authors: Bakke
authors: Division of Infection and Immunity Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.
authors: Peter M A
authors: PM
authors: Calverley
authors: Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Harvey
authors: H
authors: Coxson
authors: GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
authors: Courtney
authors: C
authors: Crim
authors: GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
authors: Lisa D
authors: LD
authors: Edwards
authors: GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
authors: Nick
authors: N
authors: Locantore
authors: Division of Medicine, University College London, London, UK.
authors: David A
authors: DA
authors: Lomas
authors: GlaxoSmithKline Research and Development, King of Prussia, Pennsylvania, USA.
authors: Bruce E
authors: BE
authors: Miller
authors: Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors: Stephen I
authors: SI
authors: Rennard
authors: Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: Emiel F M
authors: EF
authors: Wouters
authors: GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
authors: Julie C
authors: JC
authors: Yates
authors: Channing Division of Network Medicine and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors: Edwin K
authors: EK
authors: Silverman
authors: Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain.
authors: Alvar
authors: A
authors: Agusti
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D008137:Longitudinal Studies; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
keywords: Emphysema