title: [Preventive administration of antibiotics to patients with benign prostatic hyperplasia before urodynamic examination].
abstract: OBJECTIVE
  To discuss the effect and safety of preventive administration of antibiotics to patients with benign prostatic hyperplasia (BPH) before urodynamic examination.
  
  
  METHODS
  A total of 256 BPH patients to undergo urodynamic examination were randomly divided into a control group (n = 118) and a trial group (n = 138). The former received no pre-treatment while the latter were given cefoxitin sodium iv at 1.0 g 30 minutes before complete urodynamic examination. Then we compared the incidence rates of urinary tract infection between the two groups.
  
  
  RESULTS
  Statistically significant differences were found in the incidence rate of urinary tract infection between the control and trial groups (20.3% [24/118] vs 7.3% [10/138], P < 0.01), as well as in those with diabetes mellitus (6.7% [3/45] vs 23.5% [8/34], P < 0.05), those with residual urine > 50 ml (5.4% [3/56] vs 18.5% [10/54], P < 0.05), and those with both diabetes mellitus and residual urine (9.5% [2/21] vs 44.4% [8/18], P < 0.05). Only 3 patients (2.2%) in the trial group had mild adverse drug reactions.
  
  
  CONCLUSIONS
  For BPH patients, particularly those with diabetes mellitus and residual urine, preventive administration of antibiotics before urodynamic examination is safe and can effectively protect the patients against urinary tract infection.
authors: Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China. liuningseu@163.com
authors: Ning
authors: N
authors: Liu
authors: Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China.
authors: Ming
authors: M
authors: Chen
authors: Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China.
authors: Shu-Qiu
authors: SQ
authors: Chen
authors: Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China.
authors: Bin
authors: B
authors: Xu
authors: Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China.
authors: Xiao-Yun
authors: XY
authors: Mao
mesh_terms: D019072:Antibiotic Prophylaxis; D002440:Cefoxitin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000175:diagnosis*; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014563:Urodynamics
chemical_list: D002440:Cefoxitin