title: Neuroprotective effects of heptapeptide mystixin.
abstract: Neuroprotective effects of heptapeptide mystixin were studied on the neurons of the olfactory cortex in cultured slices of rat brain. Repeated applications of mystixin in doses of 100 mg/ml on brain slices rapidly reduced the amplitudes of AMPA and NMDA receptor-dependent processes. The effects were reversible and activities of these processes partly restored after washout. The peptide in a dose of 250 mg/ml suppressed epileptic discharges induced by chemical convulsive agent pentylenetetrazole. Thus, heptapeptide mystixin exhibited significant neuroprotective properties.
authors: I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint-Petersburg, Russia. mok@inbox.ru.
authors: A A
authors: AA
authors: Mokrushin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D018682:GABA Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009833:Olfactory Pathways / Q000187:drug effects / Q000503:physiopathology; D009842:Oligopeptides / Q000494:pharmacology*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D018682:GABA Agents; D018696:Neuroprotective Agents; D009842:Oligopeptides; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C110632:mystixin 7; D010433:Pentylenetetrazole