title: A higher frequency of CD4⁺CXCR5⁺ T follicular helper cells in patients with newly diagnosed IgA nephropathy.
abstract: The frequency of different subsets of CD4(+)CXCR5(+) TFH cells and the levels of serum cytokines were examined in 24 patients with newly diagnosed IgAN before and 8-12 weeks after treatment and in 12 healthy controls (HC). In comparison with HC, significantly higher percentages of CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+), CD4(+)CXCR5(+)PD-1(+) TFH cells and higher levels of serum IL-17A, IFN-γ, IL-2, IL-10, IL-4 and IL-21 were detected in IgAN patients. The percentages of CD4(+)CXCR5(+) TFH cells were negatively correlated with the values of eGFR and CD4(+)CXCR5(+)PD-1(+) TFH cells were correlated positively with the levels of serum IL-21 and Gd-IgA1 as well as 24h urinary proteins. Treatment with prednisone significantly reduced the frequency of CD4(+)CXCR5(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells and the levels of serum IL-21, but increased IL-4 and IL-10 in those patients. A higher frequency of CD4(+)CXCR5(+) TFH cells existed in patients with IgAN and may be associated with the development of IgAN.
authors: Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China; Department of Nephrology, the First Hospital of Jilin University, Changchun 130021, China.
authors: Li
authors: L
authors: Zhang
authors: Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China; Department of Nephrology, the First Hospital of Jilin University, Changchun 130021, China.
authors: Yingying
authors: Y
authors: Wang
authors: Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China.
authors: Xu
authors: X
authors: Shi
authors: Department of Nephrology, the First Hospital of Jilin University, Changchun 130021, China.
authors: Hongbin
authors: H
authors: Zou
authors: Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China. Electronic address: yanfangjiang@hotmail.com.
authors: Yanfang
authors: Y
authors: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism; D056831:Coordination Complexes; D016207:Cytokines / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism; D054380:Receptors, CXCR5 / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D015704:CD4 Antigens; C095085:CXCR5 protein, human; D056831:Coordination Complexes; D016207:Cytokines; D007070:Immunoglobulin A; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D054380:Receptors, CXCR5; D011241:Prednisone
keywords: IgA nephropathy; Prednisone; TFH cell