title: Naturally occurring methyl salicylate glycosides.
abstract: As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates' without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.
authors: Ping
authors: P
authors: Mao
authors: Zizhen
authors: Z
authors: Liu
authors: Meng
authors: M
authors: Xie
authors: Rui
authors: R
authors: Jiang
authors: Weirui
authors: W
authors: Liu
authors: Xiaohong
authors: X
authors: Wang
authors: Shen
authors: S
authors: Meng
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. shegaimei@126.com.
authors: Gaimei
authors: G
authors: She
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D055808:Drug Discovery; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D012459:Salicylates / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D006027:Glycosides; D012459:Salicylates; C033069:methyl salicylate