title: Benefits of acupuncture for diabetic gastroparesis: a comparative preliminary study.
abstract: OBJECTIVE
  The aim of this preliminary study was to compare the effectiveness of domperidone and acupuncture for the management of diabetic gastroparesis.
  
  
  METHODS
  This was a preliminary, prospective non-randomised, unblinded case-crossover study conducted in patients with longstanding, uncontrolled diabetes mellitus and gastroparesis. All patients received domperidone (20 mg four times a day) for 12 weeks, followed by a 2-3 week washout period, and then biweekly acupuncture treatments for 8 weeks. Gastric emptying rate, glucose and glycated haemoglobin (HbA1C) levels were measured at start and end of each treatment period. At each of these timepoints patients completed the Gastroparesis Cardinal Symptom Index (GCSI), the Satisfaction with Life Scale (SWLS), and the Short-Form 36 Health Survey Update (SF-36).
  
  
  RESULTS
  The trial was curtailed after only eight participants could be recruited in 3 years. The mean age of patients was 57.1±9.9 years, the male:female ratio was 1:7 and mean body mass index (kg/m(2)) was 25.2±1.2. There was no change in any of the outcome parameters after treatment with domperidone. Acupuncture was associated with a decrease in scores for almost all cardinal symptoms of the GCSI, as well as in increased total score on the SWLS (p=0.002) and the social functioning domain of the SF-36 (p=0.054). Acupuncture did not lead to an improvement in gastric emptying, or glucose control from baseline.
  
  
  CONCLUSIONS
  Acupuncture treatment may lead to symptomatic improvement in patients with diabetic gastroparesis. Within the limitations of this preliminary, non-randomised and unblinded study, it appears that this effect may be due to non-specific mechanisms.
authors: The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, , Haifa, Israel.
authors: Netanella
authors: N
authors: Danielli Miller
authors: Elad
authors: E
authors: Schiff
authors: Eran
authors: E
authors: Ben-Arye
authors: Joelle
authors: J
authors: Singer
authors: Tsachi
authors: T
authors: Tsadok Perets
authors: Shlomit
authors: S
authors: Flaut
authors: Nadav
authors: N
authors: Sahar
authors: Yaron
authors: Y
authors: Niv
authors: Ram
authors: R
authors: Dickman
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005746:Gastric Emptying; D018589:Gastroparesis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: Acupuncture; Diabetes; Internal Medicine