title: Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction.
abstract: A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.
authors: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland. cvengros@inorg.chem.ethz.ch.
authors: Alex
authors: A
authors: Lauber
authors: Benjamin
authors: B
authors: Zelenay
authors: Ján
authors: J
authors: Cvengroš
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds