title: Epidemiology of head and neck squamous cell cancer among HIV-infected patients.
abstract: BACKGROUND
  HIV-infected individuals have a higher incidence of head and neck cancer (HNC).
  
  
  METHODS
  Case series of 94 HIV-infected HNC patients (HIV-HNC) at 6 tertiary care referral centers in the US between 1991 and 2011. Clinical and risk factor data were abstracted from the medical record. Risk factors for survival were analyzed using Cox proportional hazard models. Human papillomavirus (HPV) and p16 testing was performed in 46 tumors. Findings were compared with Surveillance Epidemiology and End Results HNC (US-HNC) data.
  
  
  RESULTS
  This study represents the largest HIV-HNC series reported to date. HIV-HNC cases were more likely than US-HNC to be male (91% vs. 68%), younger (median age, 50 vs. 62 years), nonwhite (49% vs. 18%), and current smokers (61% vs. 18%). Median HIV-HNC survival was not appreciably lower than US-HNC survival (63 vs. 61 months). At diagnosis, most cases were currently on highly active antiretroviral therapy (77%) but had detectable HIV viremia (99%), and median CD4 was 300 cells per microliter (interquartile range = 167-500). HPV was detected in 30% of HIV-HNC and 64% of HIV-oropharyngeal cases. Median survival was significantly lower among those with CD4 counts ≤200 than >200 cells per microliter at diagnosis (16.1 vs. 72.8 months, P < 0.001). In multivariate analysis, poorer survival was associated with CD4 <100 cells per microliter [adjusted hazard ratio (aHR) = 3.09, 95% confidence interval (CI): 1.15 to 8.30], larynx/hypopharynx site (aHR = 3.54, 95% CI: 1.34 to 9.35), and current tobacco use (aHR = 2.54, 95% CI: 0.96 to 6.76).
  
  
  CONCLUSIONS
  Risk factors for the development of HNC in patients with HIV infection are similar to the general population, including both HPV-related and tobacco/alcohol-related HNC.
authors: *Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; †Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, MI; ‡Department of Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX; §Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA; ‖Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY; ¶Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI; #Department of Otolaryngology/Head and Neck Surgery, Johns Hopkins University, Baltimore, MD; **Cancer Biology Program, University of Michigan, Ann Arbor, MI; ††Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX; §§Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA; and ‖‖Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
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mesh_terms: D000437:Alcoholism / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000453:epidemiology*; D030361:Papillomavirus Infections / Q000150:complications; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D062606:Tertiary Care Centers; D014481:United States / Q000453:epidemiology