title: Clinical, MRI, and CSF markers of disability progression in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic disorder of the central nervous system (CNS) in which the complex interplay between inflammation and neurodegeneration determines varying degrees of neurological disability. For this reason, it is very difficult to express an accurate prognosis based on purely clinical information in the individual patient at an early disease stage. Magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers are promising sources of prognostic information with a good potential of quantitative measure, sensitivity, and reliability. However, a comprehensive MS outcome prediction model combining multiple parameters is still lacking. Current relevant literature addressing the topic of clinical, MRI, and CSF markers as predictors of MS disability progression is reviewed here.
authors: Section of Clinical Neurology, Department of Neurological and Movement Sciences, University of Verona, Neurology Unit, Borgo Roma, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Ludovico Antonio Scuro 9, 37134 Verona, Italy.
authors: Alberto
authors: A
authors: Gajofatto
authors: Massimiliano
authors: M
authors: Calabrese
authors: Maria Donata
authors: MD
authors: Benedetti
authors: Salvatore
authors: S
authors: Monaco
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology; D011379:Prognosis
chemical_list: D015415:Biomarkers