title: Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.
abstract: Obesity-induced inflammation is characterized by recruitment of adipose tissue macrophages that release inflammatory cytokines and chemokines. MIP-1α (macrophage inflammatory protein 1α)/CCL3, a CC chemokine, induces monocyte/macrophage infiltration and thus is implicated in obesity-induced adipose inflammation. Quercetin has been shown to modulate obesity-induced inflammation, but the mechanism of its action remains unclear. Here we demonstrate that quercetin decreases MIP-1α release from adipocytes and macrophages and from cocultured adipocytes/macrophages; it also opposes MIP-1α-induced macrophage infiltration and activation. The inhibitory action of quercetin on the MIP-1α-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IκBα degradation. These findings suggest that quercetin may be a useful agent against obesity-induced adipose tissue inflammation.
authors: 1 Department of Food Science and Nutrition, University of Ulsan , Ulsan, South Korea .
authors: Hye-Ji
authors: HJ
authors: Noh
authors: Chu-Sook
authors: CS
authors: Kim
authors: Ji-Hye
authors: JH
authors: Kang
authors: Jun-Young
authors: JY
authors: Park
authors: Suck-Young
authors: SY
authors: Choe
authors: Soon-Myoung
authors: SM
authors: Hong
authors: Hoon
authors: H
authors: Yoo
authors: Taesun
authors: T
authors: Park
authors: Rina
authors: R
authors: Yu
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D054405:Chemokine CCL3 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects; D018920:Coculture Techniques; D017077:Culture Media, Conditioned; D015536:Down-Regulation / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009765:Obesity / Q000150:complications; D011794:Quercetin / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D054388:Receptors, CCR / Q000235:genetics*; D054389:Receptors, CCR1 / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D054405:Chemokine CCL3; D017077:Culture Media, Conditioned; D012333:RNA, Messenger; D054388:Receptors, CCR; D054389:Receptors, CCR1; D019713:Receptors, CCR5; D011794:Quercetin; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases
keywords: adipose tissue; chemokine; inflammation; obesity; quercetin