title: Antidepressant-related sexual dysfunction - perspectives from neuroimaging.
abstract: Sexual dysfunction is not only a common symptom in major depression but also a frequent side-effect of antidepressant medication, mainly of the selective serotonin reuptake-inhibitors (SSRI) that are often prescribed as a first line treatment option. Despite of the increasing incidence and prescription rates, neuronal mechanisms underlying SSRI-related sexual dysfunction are poorly understood and investigations on this topic are scarce. Neuroimaging techniques, mainly functional magnetic resonance imaging (fMRI), provide a feasible approach to investigate these mechanisms since SSRI-related sexual dysfunction is most likely related to central nervous processes. This review summarizes the recent literature regarding the basic clinical findings and imaging correlates of antidepressant-related sexual dysfunction linking brain regions and networks potentially involved to phases and subcomponents of sexual processing and antidepressant action. In particular, fMRI studies on SSRI antidepressants including paroxetine and SNRIs including bupropion are highlighted.
authors: Department of Psychiatry, Ulm University, Leimgrubenweg 12-14, 89075 Ulm, Germany. Electronic address: heiko.graf@uni-ulm.de.
authors: Heiko
authors: H
authors: Graf
authors: Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Brenneckestraße 6, 39118 Magdeburg, Germany; Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118 Magdeburg, Germany. Electronic address: martin.walter@med.ovgu.de.
authors: Martin
authors: M
authors: Walter
authors: Department of Psychiatry, Ulm University, Leimgrubenweg 12-14, 89075 Ulm, Germany; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Brenneckestraße 6, 39118 Magdeburg, Germany. Electronic address: cora@canlab.de.
authors: Coraline D
authors: CD
authors: Metzger
authors: Department of Psychiatry, Ulm University, Leimgrubenweg 12-14, 89075 Ulm, Germany. Electronic address: birgit.abler@uni-ulm.de.
authors: Birgit
authors: B
authors: Abler
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D016642:Bupropion / Q000009:adverse effects; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017374:Paroxetine / Q000009:adverse effects; D011600:Psychopharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D016642:Bupropion; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Antidepressants; Neuroimaging; SSRI; Sexual dysfunction; fMRI