title: Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes.
abstract: Myosin 1g (Myo1g) is a hematopoietic-specific myosin expressed mainly by lymphocytes. Here, we report the localization of Myo1g in B-cell membrane compartments such as lipid rafts, microvilli, and membrane extensions formed during spreading. By using Myo1g-deficient mouse B cells, we detected abnormalities in the adhesion ability and chemokine-induced directed migration of these lymphocytes. We also assessed a role for Myo1g in phagocytosis and exocytosis processes, as these were also irregular in Myo1g-deficient B cells. Taken together, our results show that Myo1g acts as a main regulator of different membrane/cytoskeleton-dependent processes in B lymphocytes.
authors: Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
authors: José L
authors: JL
authors: Maravillas-Montero
authors: Orestes
authors: O
authors: López-Ortega
authors: Genaro
authors: G
authors: Patiño-López
authors: Leopoldo
authors: L
authors: Santos-Argumedo
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D002448:Cell Adhesion / Q000235:genetics; D002465:Cell Movement / Q000235:genetics* / Q000276:immunology*; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D005260:Female; D051379:Mice; D018345:Mice, Knockout; D015778:Minor Histocompatibility Antigens; D009218:Myosins / Q000235:genetics* / Q000378:metabolism; D021381:Protein Transport
chemical_list: D015778:Minor Histocompatibility Antigens; C588241:Myo1g protein, mouse; D009218:Myosins
keywords: B lymphocyte; Chemotaxis; Cytoskeleton; Exo-endocytosis; Myosin