title: Monitoring NK cell activity in patients with hematological malignancies.
abstract: Natural killer (NK) cells are lymphocytes of the innate immune system that can recognize and kill various types of malignant cells. Monitoring the activity of peripheral NK cells in patients affected by hematological malignancies may provide prognostic information or unveil ongoing tumor-specific immune responses. Moreover, further insights into the biology of NK cells might also promote the development of novel strategies for stimulating their anticancer activity. Here, we review the main methods to monitor phenotypic and functional NK cell properties in cancer patients, focusing on individuals affected by multiple myeloma, a hematological malignancy currently treated with immunomodulatory drugs.
authors: CIRI, International Center for Infectiology Research; Université de Lyon; Lyon, France ; Inserm, U1111; Lyon, France ; Ecole Normale Supérieure de Lyon; Lyon, France ; Université Lyon 1; Centre International de Recherche en Infectiologie; Lyon, France ; CNRS, UMR5308; Lyon, France ; Laboratoire d'Immunologie; Hospices Civils de Lyon; Centre Hospitalier Lyon Sud; Lyon, France.
authors: Sébastien
authors: S
authors: Viel
authors: Emily
authors: E
authors: Charrier
authors: Antoine
authors: A
authors: Marçais
authors: Paul
authors: P
authors: Rouzaire
authors: Jacques
authors: J
authors: Bienvenu
authors: Lionel
authors: L
authors: Karlin
authors: Gilles
authors: G
authors: Salles
authors: Thierry
authors: T
authors: Walzer
keywords: Lenalidomide; cytotoxicity; flow cytometry; multiple myeloma; natural killer cells