title: Cerebral aneurysms: formation, progression, and developmental chronology.
abstract: The prevalence of unruptured intracranial aneurysms (UIAs) in the general population is up to 3%. Existing epidemiological data suggests that only a small fraction of UIAs progress towards rupture over the lifetime of an individual, but the surrogates for subsequent rupture and the natural history of UIAs are discussed very controversially at present. In case of rupture of an UIA, the case fatality is up to 50%, which therefore continues to stimulate interest in the pathogenesis of cerebral aneurysm formation and progression. Actual data on the chronological development of cerebral aneurysm has been especially difficult to obtain and, until recently, the existing knowledge in this respect is mainly derived from animal or mathematical models or short-term observational studies. Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms.
authors: Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Dusseldorf, Germany, etminan@uni-duesseldorf.de.
authors: Nima
authors: N
authors: Etminan
authors: Bruce A
authors: BA
authors: Buchholz
authors: Rita
authors: R
authors: Dreier
authors: Peter
authors: P
authors: Bruckner
authors: James C
authors: JC
authors: Torner
authors: Hans-Jakob
authors: HJ
authors: Steiger
authors: Daniel
authors: D
authors: Hänggi
authors: R Loch
authors: RL
authors: Macdonald
mesh_terms: D018450:Disease Progression; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000473:pathology*; D008962:Models, Theoretical; D012307:Risk Factors