title: Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV in Belgium: a pilot study.
abstract: BACKGROUND
  Due to highly active antiretroviral therapy (HAART), HIV-1 infection has evolved from a lethal to a chronic disease. As such, health-related quality of life (HRQoL) has become an important outcome variable. The purpose of this study was to identify socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL among people living with HIV (PLHIV).
  
  
  METHODS
  This study was conducted between 1 January and 31 December 2012 at the AIDS Reference Centre of Ghent University Hospital, a tertiary care referral centre in Belgium. Validated self-report questionnaires were administered to collect socio-demographic data, to assess HRQoL (Medical Outcomes Study-HIV), depressive symptoms (Beck Depression Inventory-II) and adherence to HAART (Short Medication Adherence Questionnaire) and to screen for neurocognitive dysfunction.
  
  
  RESULTS
  A total of 237 people participated, among whom 187 (78.9%) were male. Mean age was 45.8±10.7 years and 144 (63.7%, 144/226) participants were homosexual. Median physical and mental health score (PHS, MHS) were 55.6 (IQR 48.2-60.6) and 52.0 (IQR 44.2-57.9), respectively. Multivariable regression analysis revealed that incapacity to work, depressive symptoms, neurocognitive complaints (NCCs), dissatisfaction with the patient-physician relationship and non-adherence were all negatively associated with HRQoL.
  
  
  CONCLUSIONS
  Socio-economic (work status), behavioural (adherence) and (neuro)psychological (depressive symptoms, NCCs) determinants independently impact HRQoL among this cohort of PLHIV. Clinical parameters (viral load, CD4 cell count) were not independently associated with HRQoL.
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium; SophieM.Degroote@UGent.be.
authors: Sophie
authors: S
authors: Degroote
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium; Faculty of Medicine and Health Sciences, Department of Internal Medicine, Ghent University, Ghent, Belgium.
authors: Dirk P
authors: DP
authors: Vogelaers
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: Peter
authors: P
authors: Vermeir
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: An
authors: A
authors: Mariman
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: Ann
authors: A
authors: De Rick
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: Bea
authors: B
authors: Van Der Gucht
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: Jolanda
authors: J
authors: Pelgrom
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium.
authors: Filip
authors: F
authors: Van Wanzeele
authors: AIDS Reference Laboratory Ghent, Faculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.
authors: Chris
authors: C
authors: Verhofstede
authors: Department of General Internal Medicine, Infectious Diseases and Psychosomatics, Ghent University Hospital, Ghent, Belgium; Faculty of Medicine and Health Sciences, Department of Public Health, Ghent University, Ghent, Belgium; Department of Health Economics & Patient Safety, Hasselt University, Faculty of Business Economics, Diepenbeek, Belgium.
authors: Dominique M
authors: DM
authors: Vandijck
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001530:Belgium; D003863:Depression / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D011584:Psychology; D011788:Quality of Life / Q000523:psychology*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
keywords: AIDS; HIV; MOS-HIV; outcome; psychosocial; quality of life