title: Severe renal failure and hyperammonemia in a newborn with propionic acidemia: effects of treatment on the clinical course.
abstract: Neonatal-onset propionic acidemia (PA), the most common form, is characterized by poor feeding, vomiting, and somnolence in the first days of life in a previously healthy infant, followed by lethargy, seizures, and can progress to coma if not identified and treated appropriately. It is frequently accompanied by metabolic acidosis with anion gap, ketonuria, hypoglycemia, hyperammonemia, and cytopenias. PA is caused by deficiency of propionyl-CoA carboxylase (PCC), the enzyme that catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA. Herein, we report a case of 3-day-old neonate with PA presented with acute renal failure and metabolic acidosis was effectively treated by peritoneal dialysis and conventional methods.
authors: Pediatric Metabolic Unit .
authors: Ciğdem Seher
authors: CS
authors: Kasapkara
authors: Melek
authors: M
authors: Akar
authors: Zeynep Nagehan
authors: ZN
authors: Yürük Yıldırım
authors: Heybet
authors: H
authors: Tüzün
authors: Berat
authors: B
authors: Kanar
authors: Mehmet Nuri
authors: MN
authors: Ozbek
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000209:etiology* / Q000628:therapy*; D007231:Infant, Newborn; D010530:Peritoneal Dialysis; D056693:Propionic Acidemia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*