title: Lateralized cortical involvement and contralateral parkinsonism without basal ganglia involvement in two autopsy cases of corticobasal syndrome-Alzheimer's disease.
abstract: Corticobasal syndrome (CBS) is characterized by lateralized motor disturbance due to levodopa nonresponsive parkinsonism and progressive apraxia. Although CBS is neuropathologically heterogeneous, it remains unclear whether the clinical features of all CBS cases are the same. We report two autopsy cases diagnosed clinically as CBS and pathologically as Alzheimer's disease characterized by lateralized cerebral cortical degeneration and absence of significant nigrostriatial lesions. Cerebral cortical degeneration in both cases was contralateral to their motor disturbances. Thus, nigrostriatial lesions and contralateral cerebral cortical lesions can cause motor disturbances in CBS, necessitating the need for bedside examination in patients with CBS.
authors: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan Department of Pathology, Ebara Hospital, Tokyo, Japan Department of Pathology, Saitama Medical University, Saitama, Japan.
authors: Taku
authors: T
authors: Homma
authors: Department of Neurology, Ebara Hospital, Tokyo, Japan.
authors: Hideki
authors: H
authors: Takubo
authors: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors: Kazushi
authors: K
authors: Takahashi
authors: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors: Shiro
authors: S
authors: Matsubara
authors: Department of Pathology, Ebara Hospital, Tokyo, Japan.
authors: Manabu
authors: M
authors: Takahashi
authors: Department of Pathology, Ebara Hospital, Tokyo, Japan Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Nobuaki
authors: N
authors: Funata
authors: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center, Tokyo, Japan.
authors: Yoko
authors: Y
authors: Mochizuki
authors: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors: Toshio
authors: T
authors: Mizutani
authors: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors: Takashi
authors: T
authors: Komori
authors: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute for Medical Science, Tokyo, Japan.
authors: Toshiki
authors: T
authors: Uchihara
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001344:Autopsy; D001479:Basal Ganglia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Alzheimer's disease; cerebral cortex; corticobasal syndrome; parkinsonism; striatonigral system