title: Central retinal vein occlusion in a young patient following cannabis smoke inhalation.
abstract: OBJECTIVE
  To report a case of central retinal vein occlusion (CRVO) following cannabis smoke inhalation in a young patient.
  
  
  METHODS
  An otherwise healthy 18-year-old man without risk factors for retinal vein occlusion presented with reduced visual acuity (20/200) secondary to CRVO following cannabis smoke inhalation. Central retinal vein occlusion was diagnosed on the basis of slit-lamp fundus biomicroscopy and fluorescein angiography.
  
  
  RESULTS
  Tests for systemic causes were negative. Following one intravitreal dexamethasone implant (Ozurdex) and one ranibizumab injection (Lucentis), functional (20/20 visual acuity) and anatomic improvement was recorded. Fluorescein angiography showed a decrease in the vascular caliber and tortuosity, with no signs of retinal ischemia or edema.
  
  
  CONCLUSIONS
  We report CRVO in a young adult following cannabis smoke inhalation. Its occurrence immediately after cannabis smoking further supports a link between the use of cannabis and vascular alterations.
authors: 1 Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan - Italy.
authors: Federico
authors: F
authors: Corvi
authors: Giuseppe
authors: G
authors: Querques
authors: Rosangela
authors: R
authors: Lattanzio
authors: Chiara
authors: C
authors: Preziosa
authors: Maurizio Battaglia
authors: MB
authors: Parodi
authors: Francesco
authors: F
authors: Bandello
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D002188:Cannabis; D003907:Dexamethasone / Q000008:administration & dosage; D004343:Drug Implants; D004359:Drug Therapy, Combination; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008385:Marijuana Smoking / Q000009:adverse effects*; D000069579:Ranibizumab; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D004343:Drug Implants; D005938:Glucocorticoids; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D003907:Dexamethasone; D000069579:Ranibizumab