title: Orbital immunoglobulin-G4-related disease: case series and literature review.
abstract: Immunoglobulin-G4-related disease (IgG4-RD) is a distinct group of diseases characterized by elevated serum IgG4 titres and infiltration of affected organs by IgG4-positive plasma cells. IgG4-RD can involve any ocular adnexal tissue. They have a distinct prognosis and pattern of tissue involvement and hence need to be differentiated from orbital lesions with similar clinicopathological features. We report three cases of IgG4-RD and review the literature extensively discussing various aspects of this novel entity.
authors: National Reporting Centre for Ophthalmic Pathology (NRCOP), Centre for Sight, Hyderabad, India; Ophthalmic Pathology Service, L.V. Prasad Eye Institute, Hyderabad, India.
authors: Kaustubh
authors: K
authors: Mulay
authors: Ekta
authors: E
authors: Aggarwal
authors: Mehul
authors: M
authors: Jariwala
authors: Santosh G
authors: SG
authors: Honavar
mesh_terms: D001327:Autoimmune Diseases; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007765:Lacrimal Apparatus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents
keywords: IgG4-related disease; extraocular muscle; immunoglobulin-G4; orbital