title: In vivo antinociceptive and anticonvulsant activity of extracts of Heliotropium strigosum.
abstract: Natural healing agents are primarily focused to overcome unwanted side effects with synthetic drugs worldwide. In the proposed study, crude extracts and subsequent solvent fractions of Heliotropium strigosum were evaluated for antinociceptive and anticonvulsant activity in animal paradigms. In post acetic acid-induced writhing test, crude extract and fractions (hexane, ethyl acetate, and aqueous) demonstrated marked attenuation of nociception at test doses (50, 100, and 200 mg/kg i.p.). When challenged against thermally induced pain model, pretreatment of extracts exhibited prominent amelioration at test dose (50, 100, and 200 mg/kg i.p.). In both tests, inhibition of noxious stimulation was in a dose-dependent manner, and ethyl acetate fraction was most dominant. However, extracts did not antagonize the seizures and mortality induced by pentylenetetrazole. In conclusion, the extracts of H. strigosum illustrated significant antinociceptive effect in both centrally and peripherally acting pain models.
authors: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.
authors: Haroon
authors: H
authors: Khan
authors: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors: Murad Ali
authors: MA
authors: Khan
authors: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors: Sajid
authors: S
authors: Hussain
authors: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
authors: Rukhsana
authors: R
authors: Gaffar
authors: International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors: Nadeem
authors: N
authors: Ashraf
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D028162:Heliotropium / Q000737:chemistry*; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010433:Pentylenetetrazole / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010936:Plant Extracts; D010433:Pentylenetetrazole
keywords: Heliotropium strigosum; anticonvulsant; antinociceptive