title: Results of liver transplants from donors aged 70 plus: analysis of Andalusian transplant register.
abstract: The progressive increase in the number of liver transplantation candidates has brought with it a consequent increase in waiting list mortality, making it necessary to revise donor selection criteria and to analyze the factors that optimize outcomes. This retrospective observational study of 1802 liver transplantations performed in Andalusia between 2000 and 2010 analyzes the outcomes from donors aged 70 years or older (n = 211) in terms of survival rates of the graft and the recipient, the type of transplant, donor age, and DMELD (Donor-Model for End-Stage Liver Disease) score. The most frequent reasons for transplantation were alcoholic cirrhosis (45.5%), hepatitis C cirrhosis (20.4%), and liver cancer (11.8%). The overall survival rate at 5 years was 67%; with a significant decrease in survival rates for recipients with a DMELD greater than 1400 (44%). In the 70-year-old-plus donor group, the overall patient and graft survival rates were 57% and 52%, respectively. The re-transplantation rate increased proportionately with donor age: 5.9% between 70 and 74 years, 9.5% from 75 to 79 years, and 17.6% from 80 to 84 years. In the alcoholic cirrhosis recipient sub-group, the overall survival rate at 5 years was 69% (P < .05) compared to 34% in hepatitis C patients (P < .05). The widening of the donor age selection criteria is therefore a safe option, provided that a DMELD score less than 1400 is obtained. Although re-transplantation rates increase progressively with donor age, they remain less than 10%. It is necessary to carefully screen recipients of older organs, taking into account that the best results are obtained for patients who have alcoholic cirrhosis, are hepatitis C negative, and have a DMELD score that is less than 1,400.
authors: Liver Transplant Unit, Virgen del Rocío University Hospital, Seville, Spain. Electronic address: carmencepedafranco@gmail.com.
authors: C C
authors: CC
authors: Franco
authors: J M A
authors: JM
authors: Martínez
authors: C B
authors: CB
authors: Bellido
authors: G S
authors: GS
authors: Artacho
authors: L M M
authors: LM
authors: Gómez
authors: J S
authors: JS
authors: Diez-Canedo
authors: C D
authors: CD
authors: Aunión
authors: F J P
authors: FJ
authors: Ruiz
authors: M A G
authors: MA
authors: Bravo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D046148:Donor Selection; D006085:Graft Survival; D006526:Hepatitis C / Q000401:mortality / Q000601:surgery; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000401:mortality / Q000601:surgery; D008107:Liver Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D018579:Patient Selection; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain; D016019:Survival Analysis; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D016896:Treatment Outcome; D014850:Waiting Lists