title: Activation and retention: a magnetic resonance probe for the detection of acute thrombosis.
abstract: Blood-clot formation that results in the complete occlusion of a blood vessel (thrombosis) often leads to serious life-threatening events, such as strokes and heart attacks. As the composition of a thrombus changes as it matures, new imaging methods that are capable of distinguishing new clots from old clots may yield important diagnostic and prognostic information. To address this need, an activatable magnetic resonance (MR) probe that is responsive to a key biochemical process associated with recently formed clots has been developed.
authors: A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129 (USA).
authors: Galen S
authors: GS
authors: Loving
authors: Peter
authors: P
authors: Caravan
mesh_terms: D000208:Acute Disease; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D005682:Gadolinium / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D019704:Protein Disulfide-Isomerases / Q000378:metabolism; D020246:Venous Thrombosis / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; C503783:EP-2104R; D010455:Peptides; D005682:Gadolinium; D019704:Protein Disulfide-Isomerases
keywords: disulfide bonds; enzymatic activation; fibrin; imaging agents; magnetic resonance imaging