title: Use of Fomepizole in Pediatric Methanol Exposure: The First Case Report in Taiwan and a Literature Review.
abstract: Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic metabolites derived from the oxidation of methanol. However, clinical experience in pediatric methanol poisoning is limited, and the safety profiles of the antidotes have not been established in children, especially in Asian populations. This is the first case to describe the use of fomepizole in a child with methanol exposure in Taiwan.
authors: Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
authors: Tzu-Hua
authors: TH
authors: Chen
authors: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
authors: Chang-Hung
authors: CH
authors: Kuo
authors: Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Chia-Tsuan
authors: CT
authors: Huang
authors: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Pediatrics, True Generation Hospital, Kaohsiung, Taiwan. Electronic address: fordrwang@yahoo.com.tw.
authors: Wei-Li
authors: WL
authors: Wang
mesh_terms: D000931:Antidotes / Q000627:therapeutic use*; D000077604:Fomepizole; D006801:Humans; D007223:Infant; D008297:Male; D000432:Methanol / Q000506:poisoning*; D011720:Pyrazoles / Q000627:therapeutic use*; D013624:Taiwan
chemical_list: D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D000432:Methanol
keywords: fomepizole; methanol; pediatric