title: Immediate mobilization after coronary angiography or percutaneous coronary intervention following hemostasis with the AngioSeal vascular closure device (the MOBS study).
abstract: BACKGROUND
  In patients undergoing coronary angiography or percutaneous coronary intervention (PCI), the standard post procedure regime includes immobilization and bed rest despite the use of vascular closure devices.
  
  
  OBJECTIVE
  In the Mobilization after Coronary Angiography or Percutaneous Coronary Intervention (MOBS) study we compared bleeding complications after cardiac catheterization with femoral artery access after mobilization immediately off the angiographic table or standard care with1 hour (MOBS I after a diagnostic angiogram) or 2 hours of bed rest before mobilization (MOBS II after PCI).
  
  
  METHODS
  Bleeding complications were defined as major (requiring surgery of the femoral artery, transfusion or increased hospital stay) and minor (hematoma <5 × 5 cm(2), oozing from the puncture site or minor bleeding that could be compressed manually).
  
  
  RESULTS
  In the MOBS I cohort (100 patients were mobilized immediately and 100 patients followed standard care) no major bleeding complications were seen. In the immediate mobilization group 2.0% experienced minor bleeding compared to 4.0% in the standard care group (p=0.41). In the MOBS II cohort after PCI (158 patients were mobilized immediately and 161 patients followed standard care), major bleeding complication rates did not differ significantly between the two groups: immediate mobilization group 26.6% vs. standard care group 28.0%, p=0.78. The majority of bleeding complications were due to oozing: immediate mobilization group 22.8% vs. standard care group 20.5%, p=0.62.
  
  
  CONCLUSIONS
  Immediate mobilization after a coronary angiogram or PCI with the femoral access site closed by the closure device AngioSeal was not associated with increased bleeding risk compared to standard care with bed rest.
authors: Department of Cardiology, Odense University Hospital, Denmark Ellen.Nyholm.Larsen@rsyd.dk.
authors: Ellen Nyholm
authors: EN
authors: Larsen
authors: Department of Cardiology, Odense University Hospital, Denmark.
authors: Charlotte Bak
authors: CB
authors: Hansen
authors: Department of Cardiology, Odense University Hospital, Denmark.
authors: Per
authors: P
authors: Thayssen
authors: Department of Cardiology, Odense University Hospital, Denmark.
authors: Lisette Okkels
authors: LO
authors: Jensen
mesh_terms: D000368:Aged; D001510:Bed Rest; D015331:Cohort Studies; D017023:Coronary Angiography / Q000009:adverse effects* / Q000379:methods*; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000517:prevention & control*; D006487:Hemostasis; D006801:Humans; D007103:Immobilization / Q000379:methods*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000379:methods*; D013548:Sweden; D065506:Vascular Closure Devices
keywords: Closure device; complications; mobilization; percutaneous coronary intervention