title: Resveratrol induces insulin gene expression in mouse pancreatic α-cells.
abstract: BACKGROUND
  Type 1 and type 2 diabetes are characterized by loss of β-cells; therefore, β-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic compound, has been shown to improve glycaemic control in diabetic patients, but its action on pancreatic α-cells is not well understood.
  
  
  RESULTS
  Using mouse α-cells (αTC9), we showed that resveratrol induces expression of pancreatic β-cell genes such as Pdx1 and Ins2 in a SirT1-dependent manner. The mRNA and protein levels of insulin were further increased by histone deacetylase (HDAC) inhibition.
  
  
  CONCLUSIONS
  In summary, we provide new mechanistic insight into the anti-diabetic action of resveratrol through its ability to express β-cell genes in α-cells.
authors: Laboratory of Hormonal Regulation, Program of Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8 College Road, Singapore, Singapore.
authors: Sherwin
authors: S
authors: Xie
authors: Laboratory of Hormonal Regulation, Program of Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8 College Road, Singapore, Singapore.
authors: Rohit Anthony
authors: RA
authors: Sinha
authors: Laboratory of Hormonal Regulation, Program of Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8 College Road, Singapore, Singapore.
authors: Brijesh K
authors: BK
authors: Singh
authors: Department of Clinical Research, Singapore General Hospital, Singapore 169857, Singapore.
authors: Guo Dong
authors: GD
authors: Li
authors: Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, ASTAR, Singapore, Singapore.
authors: Weiping
authors: W
authors: Han
authors: Laboratory of Hormonal Regulation, Program of Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8 College Road, Singapore, Singapore.
authors: Paul M
authors: PM
authors: Yen