title: Nanoneedle-assisted delivery of site-selective peptide-functionalized DNA nanocages for targeting mitochondria and nuclei.
abstract: Peptide-functionalized DNA nano-objects selectively target mitochondria and the nucleus by means of nanoneedle-assisted delivery. This technology preserves the cell viability and structural integrity of nanostructures and assists the nano-objects in escaping degradation by endocytosis. This method opens up a new avenue for further in vitro studies of intracellular behaviors of DNA assemblies and their interactions in specific organelles.
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
authors: Miu Shan
authors: MS
authors: Chan
authors: Pik Kwan
authors: PK
authors: Lo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016923:Cell Death; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D016503:Drug Delivery Systems; D031541:Fluorescence Resonance Energy Transfer; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010455:Peptides; D004247:DNA
keywords: DNA nanocages; mitochondria; nuclei; silicon nanoneedles; targeting