title: Mechanisms and treatments for renal artery stenosis.
abstract: Atherosclerotic renal artery stenosis (ARAS) is a common and complicated disease, which can result in high blood pressure and loss of kidney function. Although progress has been made in the understanding and treatment of hypertension in relation to ARAS, much less progress has been made in the area of renal function. Here we discuss current treatment options in regard to medical therapy and revascularization. We also describe the proposed mechanisms leading to renal dysfunction, including the CD40 signaling cascade, which is a particularly attractive signaling mechanism that may provide a mechanistic rationale for the development of renal disease in ARAS.
authors: Department of Medicine, University of Toledo, Toledo, Ohio 43614, USA.
authors: Steven T
authors: ST
authors: Haller
authors: Kaleigh L
authors: KL
authors: Evans
authors: David A
authors: DA
authors: Folt
authors: Christopher A
authors: CA
authors: Drummond
authors: Christopher J
authors: CJ
authors: Cooper
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications; D019013:CD40 Antigens / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation; D007511:Ischemia; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D015995:Prevalence; D012078:Renal Artery Obstruction / Q000503:physiopathology* / Q000628:therapy*; D051437:Renal Insufficiency / Q000503:physiopathology / Q000628:therapy; D015398:Signal Transduction
chemical_list: D019013:CD40 Antigens