title: [Granulocyte-colony stimulating factor-producing urothelial carcinoma of right renal pelvis : a case report].
abstract: A 78-year-old female patient with fever and general malaise was referred to our hospital. Laboratory examination showed the marked elevation of leukocyte and serum granulocyte-colony stimulating factor (GCSF) concentration without any infectious sign. A computed tomography scan demonstrated irregular enhanced mass of the right kidney with liver metastasis. The pathological findings of the needle biopsy was high-grade urothelial cancer with positive staining for G-CSF antibody. Systemic chemotherapy with gemcitabine and cisplatin was administered. The patient showed a partial response and the serum G-CSF level was normalized after 1 course of chemotherapy. After four courses of chemotherapy, the extent of liver metastasis increased and the G-CSF concentration became elevated. Although combined chemotherapy with paclitaxel and gemcitabine was administered, the patient died 7 months after her first visit.
authors: The Department of Urology, Kuwana East Medical Center.
authors: Yoshihiro
authors: Y
authors: Nomura
authors: Maki
authors: M
authors: Kobayashi
authors: Hiroko
authors: H
authors: Enomoto
authors: Hiroshi
authors: H
authors: Imai
authors: Toshiaki
authors: T
authors: Wakita
authors: Itsuo
authors: I
authors: Yamamoto
authors: Hideaki
authors: H
authors: Kise
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D007682:Kidney Pelvis; D019459:Urothelium; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D016179:Granulocyte Colony-Stimulating Factor; D002945:Cisplatin; D000093542:Gemcitabine