title: [Effect of IL-1beta on growth properties of vaginal microsymbionts].
abstract: OBJECTIVE
  Study the effect of IL-1beta in concentrations that are characteristic for vaginal normo- and pathocenosis on growth properties of vaginal microsymbionts.
  
  
  METHODS
  Concentration of IL-1beta in vaginal contents of women during bacterial vaginosis and normocenosis was determined by using enzume immunoassay. Changes of growth characteristics and biofilm formation ability of Staphylococcus aureus, Escherichia coli, Lactobacilus spp., Corynebacterium spp. under the effect of various IL-1beta concentrations by method of O'Toole G.A. (1999) were studied.
  
  
  RESULTS
  IL-1beta in concentrations characteristic for normocenosis was shown to be able to cause stimulating effect on growth properties of lactobacilli and corynebacteria and suppress growth of S. aureus and E. coli in both plankton and biofilm cultures. IL-1beta concentrations characteristic for vaginal dysbiosis on the contrary result in suppression of growth of lactobacilli biomass against the background of stimulation of growth properties and biofilm formation ability of S. aureus and E. coli.
  
  
  CONCLUSIONS
  Differential dose-dependent effect of IL-1beta on biomass growth and biofilm formation ability of vaginal microsymbionts is a mechanism of regulation of vaginal microbiocenosis.
authors: E A
authors: EA
authors: Kremleva
authors: O V
authors: OV
authors: Bukharin
mesh_terms: D000328:Adult; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D017077:Culture Media, Conditioned; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000008:administration & dosage*; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014621:Vagina / Q000187:drug effects / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
chemical_list: D017077:Culture Media, Conditioned; D053583:Interleukin-1beta