title: Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
abstract: A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.
authors: Institute of Pharmaceutical Biology and Biotechnology and §Institute of Molecular Medicine, Heinrich-Heine University , 40225 Düsseldorf, Germany.
authors: Cong-Dat
authors: CD
authors: Pham
authors: Rudolf
authors: R
authors: Hartmann
authors: Philip
authors: P
authors: Böhler
authors: Björn
authors: B
authors: Stork
authors: Sebastian
authors: S
authors: Wesselborg
authors: Wenhan
authors: W
authors: Lin
authors: Daowan
authors: D
authors: Lai
authors: Peter
authors: P
authors: Proksch
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D047128:Callyspongia / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019169:Jurkat Cells; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C588104:callyspongiolide