title: Successful unrelated umbilical cord blood transplantation for class 3 β-thalassemia major using a reduced-toxicity regimen.
abstract: Unrelated umbilical CB transplant for class 3 β-thalassemia major is associated with an increased risk of mortality and non-engraftment. We describe two patients who underwent successful unrelated umbilical CB transplant using a novel reduced-toxicity preparative regimen. This regimen may be sufficiently immunosuppressive and myeloablative to ensure engraftment with reduced risks of toxicity and mortality. Close monitoring of HHV-6 viral load is advised for patients undergoing transplant with this regimen.
authors: Division of Heme/Onc/BMT, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
authors: Sandeep
authors: S
authors: Soni
authors: Nancy
authors: N
authors: Breslin
authors: Alexandra
authors: A
authors: Cheerva
mesh_terms: D000906:Antibodies / Q000737:chemistry; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D005355:Fibrosis; D006680:HLA Antigens / Q000737:chemistry; D015654:Herpesvirus 6, Human / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008297:Male; D019653:Myeloablative Agonists / Q000627:therapeutic use; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods*; D017086:beta-Thalassemia / Q000628:therapy*
chemical_list: D000906:Antibodies; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D019653:Myeloablative Agonists
keywords: stem cell transplant; thalassemia major; umbilical cord blood