title: Fourth cranial nerve palsy and bilateral acute retinal necrosis following human herpesvirus 6 infection of the central nervous system.
abstract: Acute retinal necrosis (ARN) is a rare, potentially blinding condition typically affecting immunocompetent individuals. It is defined by the clinical triad of vitreous inflammation, occlusive vasculopathy, and progressive retinal necrosis, usually located in peripheral retina with circumferential extension. Varicella zoster virus (VZV), herpes simplex virus (HSV), Epstein-Barr virus (EBV) and occasionally cytomegalovirus (CMV) are the common causative agents of ARN. Reports of human herpesvirus 6 (HHV6) infection of the central nervous system (CNS) associated with ocular inflammatory disease are extremely rare. We here report the case of a 22-year-old immunocompetent male who presented with acute bilateral ARN and fourth nerve palsy, following HHV6 infection of the CNS and EBV infectious mononucleosis.
authors: Department of Ophthalmology, Leicester Royal Infirmary, University of Leicester , Leicester , UK.
authors: Eleni
authors: E
authors: Papageorgiou
authors: Soon
authors: S
authors: Ch'ng
authors: Archana
authors: A
authors: Kulkarni
authors: Samira
authors: S
authors: Anwar
authors: Theodoros
authors: T
authors: Empeslidis
mesh_terms: D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D015828:Eye Infections, Viral / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000209:etiology*; D019349:Roseolovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D020432:Trochlear Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: Acute retinal necrosis; EBV; HHV6; encephalitis; fourth cranial nerve palsy