title: Mesenchymal cells emerge as primary contributors to fibrosis in multiple tissues.
abstract: A longstanding controversy exists regarding the cellular origin of myofibroblasts in tissue fibrosis. A recent study by Hung and colleagues (Am J Respir Crit Care Med 188(7):820-830, 2013) used genetic fate mapping of FoxD1 embryonic progenitor cells to show a major and direct contribution of mesenchymal cells to fibrogenesis in the lung. Future studies using FoxD1-specific inducible knockout models of pro-fibrotic genes such as CCN2 will be valuable for determining anti-fibrotic drug targets. The emergence of pericyte-like myofibroblast precursors also raises the question of whether mesenchymal stem cells in various niches contribute to fibrotic responses throughout the body.
authors: Department of Physiology and Pharmacology, Western University, Dental Science Building, London, ON, N6A 5C1, Canada, mtsang24@uwo.ca.
authors: Matthew
authors: M
authors: Tsang