title: Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy.
abstract: OBJECTIVE
  To observe the effects of intermittent one-lung ventilation (OLV) before and after surgery on the inflammatory cytokines and biomarkers of oxidative stress in serum of lung cancer patients undergoing open thoracotomy.
  
  
  METHODS
  Between June 2011 to March 2012, 80 patients undergoing lobectomy were classified into four groups nonrandomly: Group A, control group; B, OLV preconditioning group; C, OLV postconditioning group; D, OLV preconditioning-combined-with-postconditioning group. Neutrophil granulocyte (PMN), interleukin 6 (IL-6), superoxide dismutase (SOD), and malondialdehyde (MDA) were assayed in plasma samples taken preoperatively (T1), intraoperatively (T2), and 2 hours postoperatively (T3).
  
  
  RESULTS
  Comparison of T1 with T2 and T3 documented significant increase in MDA, PMN, and IL-6 levels and decrease in SOD in the control group (p < 0.01). Compared with the control group, the levels of IL-6 and MDA decreased and SOD increased significantly at T2 in the OLV preconditioning group, at T3 in the OLV preconditioning combined postconditioning group (p < 0.05).
  
  
  CONCLUSIONS
  Preconditioning of intermittent OLV before thoracotomy combined with postconditioning of intermittent returning two-lung ventilation after surgery maybe alleviate systematic inflammatory response and oxidative stress for lung cancer patients.
authors: Department of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors: Yuan-Da
authors: YD
authors: Cheng
authors: Department of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors: Yang
authors: Y
authors: Gao
authors: Department of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors: Heng
authors: H
authors: Zhang
authors: Medical Science Institute of Xiangya Hospital, Central South University, Changsha, Hunan, PR China. Electronic address: duancjxy@126.com.
authors: Chao-Jun
authors: CJ
authors: Duan
authors: Department of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR China. Electronic address: zcf6636169@sina.com.
authors: Chun-Fang
authors: CF
authors: Zhang
mesh_terms: D055371:Acute Lung Injury / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D057775:Ischemic Postconditioning; D019194:Ischemic Preconditioning; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation; D018384:Oxidative Stress / Q000502:physiology; D013908:Thoracotomy
chemical_list: D015415:Biomarkers
keywords: acute lung injury; one-lung ventilation; oxidative stress; postconditioning; preconditioning