title: Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.
abstract: Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.
authors: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors: Danilo B
authors: DB
authors: Medinas
authors: Claudio
authors: C
authors: Hetz
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism*; D011108:Polymers / Q000633:toxicity*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D019892:eIF-2 Kinase / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D055504:Insulin Receptor Substrate Proteins; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; D019892:eIF-2 Kinase