title: Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.
abstract: A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based assays employing (19)F NMR and LC-MS analyses.
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
authors: Anna M
authors: AM
authors: Rydzik
authors: Ivanhoe K H
authors: IK
authors: Leung
authors: Armin
authors: A
authors: Thalhammer
authors: Grazyna T
authors: GT
authors: Kochan
authors: Timothy D W
authors: TD
authors: Claridge
authors: Christopher J
authors: CJ
authors: Schofield
mesh_terms: D002331:Carnitine / Q000737:chemistry*; D002460:Cell Line; D004925:Escherichia; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D008745:Methylation; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D005461:Fluorine; D002331:Carnitine