title: Mechanisms of obesity-induced gastrointestinal neoplasia.
abstract: Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and associated disorders, including gastrointestinal cancers, have high morbidity and mortality. An increased understanding of the mechanisms of obesity-induced carcinogenesis is required to develop methods to prevent or treat these cancers. In this report, we review the mechanisms of obesity-associated colorectal, esophageal, gastric, and pancreatic cancers and potential treatment strategies.
authors: The Rockefeller University, New York, NY, USA.
authors: José O
authors: JO
authors: Alemán
authors: Department of Medical and Surgical Sciences, University of Bologna, Italy.
authors: Leonardo H
authors: LH
authors: Eusebi
authors: Department of Medical and Surgical Sciences, and Center for Applied Biomedical Research (CRBA), University of Bologna, Italy.
authors: Luigi
authors: L
authors: Ricciardiello
authors: Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
authors: Kavish
authors: K
authors: Patidar
authors: Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
authors: Arun J
authors: AJ
authors: Sanyal
authors: The Rockefeller University, New York, NY, USA.
authors: Peter R
authors: PR
authors: Holt
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism; D004032:Diet / Q000009:adverse effects; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D064307:Microbiota; D009765:Obesity / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction
chemical_list: D015415:Biomarkers
keywords: BE; BMI; Barrett's esophagus; CRC; Colorectal Cancer; EAC; Esophageal Cancer; GCA; GI; Gastric Cancer; IGF; IGFBP; IGFR; IL; IR; LPS; MAPK; MCP-1; MSI; PAC; Pancreatic Cancer; RR; TNF; body mass index; colorectal cancer; esophageal adenocarcinoma; gastric adenocarcinoma; gastrointestinal; insulin receptor; insulin-like growth factor; insulin-like growth factor binding protein; insulin-like growth factor receptor; interleukin; lipopolysaccharides; mTOR; mammalian target of rapamycin; microsatellite instability; mitogen-activated protein kinase; monocyte chemoattractant protein 1; pancreatic adenocarcinoma; relative risk; sTNFR2; soluble tumor necrosis factor receptor 2; tumor necrosis factor