title: Complete hydatidiform mole and a coexistent fetus following ovulation induction in a patient with Sheehan's syndrome: a first case report and review of literature.
abstract: Pregnancy in Sheehan's syndrome (SS) is extremely rare. We present the first reported case of twin pregnancy with complete hydatiform mole (CHM) and a coexistent fetus (CHCF) in a patient with SS. A 29-year-old Chinese patient with SS became pregnant following one cycle of ovulation induction with human menopausal gonadotropin after secondary infertility. A normal live fetus and a low echogenic mass suspected hydatidiform mole (HM) were detected by ultrasound examinations at gestational week 8. The couple highly desired to continue the pregnancy because it is very hard to get pregnant for the patients with SS. However, the pregnancy was terminated for the size of the HM component increased rapidly at gestational week 15. Histological examinations confirmed CHCF. Genetic studies showed that the CHM genome was derived from paternal diploidy, and the normal fetus was from biparental genomes. Furthermore, a literature review on these topics is included. This case highlighted that even in a patient with SS, twin pregnancy with CHCF can still occur after ovulation induction.
authors: Reproductive Medicine Center, Department of Obstetrics and Gynaecology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong, People's Republic of China, hxkun@fsyyy.com.
authors: Xuekun
authors: X
authors: Huang
authors: Jingyao
authors: J
authors: Liang
authors: Yonghan
authors: Y
authors: Huang
authors: Juanhua
authors: J
authors: Huang
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D005260:Female; D005328:Fetal Viability; D005333:Fetus / Q000473:pathology; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications / Q000473:pathology*; D007018:Hypopituitarism / Q000150:complications*; D010062:Ovulation Induction; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D014328:Trophoblastic Neoplasms / Q000209:etiology; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology*