title: Change in oocyte yield in repeated in vitro fertilization cycles: effect of ovarian reserve.
abstract: OBJECTIVE
  To examine factors that affect variability in oocyte yield between consecutive IVF cycles.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based fertility clinic.
  
  
  METHODS
  A total of 292 women starting two IVF cycles within 12 months from 2005 to 2011.
  
  
  METHODS
  Variables evaluated included female age, body mass index, parity, infertility diagnosis, antral follicle count (AFC), ovarian stimulation protocol, change in stimulation protocol, total dose of gonadotropin used and change in dose between cycles. Possible associations were tested using a log linear regression model.
  
  
  METHODS
  Change in total and mature oocyte yield between cycles and factors that predict this change.
  
  
  RESULTS
  In cycle 1, total and mature oocyte yield were positively associated with increased AFC and negatively associated with total gonadotropin dose. In cycle 2, a significant increase was seen in both total and mature oocytes. There were no significant independent variables that predicted this change in oocyte yield. When stratified into groups based on ovarian reserve, change in oocyte yield between cycles was significant only in patients with normal ovarian reserve (AFC >10). In this group, the only independent variable associated with an increased oocyte yield was an increase in the total gonadotropin dose.
  
  
  CONCLUSIONS
  An increase in oocyte yield between cycles was found in women with normal ovarian reserve and was associated with an increased total gonadotropin dose in the second cycle.
authors: Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
authors: Erin E
authors: EE
authors: Eppsteiner
authors: Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
authors: Amy E T
authors: AE
authors: Sparks
authors: Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
authors: Dawei
authors: D
authors: Liu
authors: Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa. Electronic address: brad-van-voorhis@uiowa.edu.
authors: Bradley J
authors: BJ
authors: Van Voorhis
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult
keywords: Oocytes; gonadotropin therapy; infertility; in vitro fertilization; ovarian stimulation