title: The effect of postoperative corticosteroid administration on free vascularized fibular grafting for treating osteonecrosis of the femoral head.
abstract: Free vascularized fibular grafting (FVFG) has been reported to be an effective method of treating osteonecrosis of the femoral head (ONFH). This study evaluated whether postoperative maintenance doses of corticosteroids had an adverse effect on FVFG outcomes in patients with corticosteroid-induced ONFH. We retrospectively reviewed the records of 39 patients (67 hips) who had received maintenance doses of corticosteroids following FVFG. This group was matched to a group of patients who had not received corticosteroids treatment after operation. The mean follow-up duration was 5.4 years for the postoperative corticosteroid administration group (PCA group) and 5.0 years for the control group. At the latest follow-up, the average increase in Harris hip score was 11.1 ± 8.7 points for all hips in the PCA group and 12.6 ± 7.4 points for all hips in the control group (P > 0.05). In the PCA group, through radiographic evaluation, 49 hips were improved, 10 hips appeared unchanged, and 8 hips appeared worse. In the control group, 47 hips were improved, 13 hips appeared unchanged, and 7 hips appeared worse. The results suggested that postoperative maintenance doses of corticosteroids do not have an adverse effect on FVFG outcomes in patients with corticosteroid-induced ONFH.
authors: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Jiao Tong University, Shanghai 200233, China.
authors: Hao
authors: H
authors: Ding
authors: Sheng-Bao
authors: SB
authors: Chen
authors: Sen
authors: S
authors: Lin
authors: You-Shui
authors: YS
authors: Gao
authors: Chang-Qing
authors: CQ
authors: Zhang
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D064595:Composite Tissue Allografts / Q000187:drug effects* / Q000637:transplantation*; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000601:surgery*; D006084:Graft Rejection; D006801:Humans; D008297:Male; D011182:Postoperative Care / Q000379:methods; D016896:Treatment Outcome; D063986:Vascularized Composite Allotransplantation / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones