title: Hodgkin lymphoma transformation of chronic lymphocytic leukemia: cases report and discussion.
abstract: B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common form of leukemia affecting adults in Europe and North America. Large B-cell lymphoma known as Richter's syndrome (RS) may develop approximately in 3-15 % patients. Furthermore, other hematological malignancies may also occur as RS variants, among them-Hodgkin lymphoma (HL). CLL/SLL transformation into HL is observed in about 0.5 % of patients, and till now, fewer than 100 cases have been reported in the medical literature. We present two cases of HL transformation of CLL/SLL and review the previously published literature.
authors: Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569, Poznan, Poland, maciej.kazmierczak@onet.eu.
authors: Maciej
authors: M
authors: Kaźmierczak
authors: Renata
authors: R
authors: Kroll-Balcerzak
authors: Andrzej
authors: A
authors: Balcerzak
authors: Elżbieta
authors: E
authors: Czechowska
authors: Lidia
authors: L
authors: Gil
authors: Krzysztof
authors: K
authors: Sawiński
authors: Andrzej
authors: A
authors: Szczepaniak
authors: Mieczysław
authors: M
authors: Komarnicki
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents