title: Immunochemical fecal occult blood test for detection of advanced colonic adenomas and colorectal cancer: comparison with colonoscopy results.
abstract: Background. Fecal immunochemical tests (FITs) have been used for colorectal cancer (CRC) screening in several countries. There is lack of information concerning diagnostic performances of this method in Brazil. Methods. Patients scheduled for elective colonoscopy provided one stool sample one week before colonoscopy. The accuracy of a qualitative FIT for detection of CRC and advanced adenomas was determined. Results. Overall 302 patients completed the study. Among them, 53.5% were high risk patients referred for screening or surveillance. Nine (3%) CRCs and 11 (3.6%) advanced adenomas were detected by colonoscopy. Sensitivity and specificity for CRC were, respectively, 88.9% and 87.6%. For advanced adenomas, sensitivity was 63.6% and specificity 87.6%. Conclusion. Our results showed good sensitivity and specificity of the FIT for detecting advanced neoplasias. This method may be a valuable tool for future screening programs in Brazil.
authors: Disciplina de Gastroenterologia, Departamento de Clínica Médica, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo 126, Campinas 13083-887, Brazil.
authors: Bianca Rosa
authors: BR
authors: Viana Freitas
authors: Cristiane
authors: C
authors: Kibune Nagasako
authors: Celia Regina
authors: CR
authors: Pavan
authors: Sônia Letícia
authors: SL
authors: Silva Lorena
authors: Fabio
authors: F
authors: Guerrazzi
authors: Cláudio
authors: C
authors: Saddy Rodrigues Coy
authors: Maria de Lourdes S
authors: Mde L
authors: Ayrizono
authors: Maria Aparecida
authors: MA
authors: Mesquita