title: Effect of exercise intensity on cerebrospinal fluid interleukin-6 concentration during recovery from exhaustive exercise in rats.
abstract: The purpose of this study was to investigate the possible role of moderate and strenuous swimming training on plasma and cerebrospinal fluid (CSF) IL-6 (interleukin-6) levels during recovery from exhaustive exercise in rats. Wistar rats were divided into three groups: sedentary control (C), moderately trained (MT) and strenuously trained (ST). MT rats underwent swimming exercise for one hour/day and 5 days/week for 8 weeks. Animals in the ST group began swimming with 1 h/day and swimming duration was progressively increased by 30 min/wk, reaching 2.5 h/day by week 4 and stayed constant for an additional 4 weeks. After all animals underwent an acute exhaustive swimming exercise, animals were divided into 3 groups, and decapitated immediately, 24 and 48 hours after exhaustion to obtain tissue samples. Muscle citrate synthase activity, plasma and CSF IL-6 levels were determined. The citrate synthase activity was found to be higher in MT and ST groups compared to the C group. Although plasma IL-6 levels were found unaltered among all groups, the CSF IL-6 concentration was found to be increased 24 hours after exhaustive exercise of the ST group. We conclude that exercise training intensity is an important factor determining cerebrospinal IL-6 concentration after exhaustive exercise.
authors: Akdeniz University School of Physical Education and Sports Arapsuyu-Antalya Turkey.
authors: M
authors: M
authors: Kılıç
authors: Akdeniz University Faculty of Arts and Sciences, Department of Biology Arapsuyu-Antalya Turkey.
authors: Ö
authors: Ö
authors: Ulusoy
authors: Akdeniz University Faculty of Medicine, Department of Physiology Arapsuyu-Antalya Turkey.
authors: S
authors: S
authors: Cırrık
authors: Akdeniz University School of Physical Education and Sports Arapsuyu-Antalya Turkey.
authors: I E
authors: IE
authors: Hindistan
authors: Akdeniz University School of Physical Education and Sports Arapsuyu-Antalya Turkey.
authors: Y Gül
authors: YG
authors: Ozkaya
mesh_terms: D000818:Animals; D001835:Body Weight; D002950:Citrate (si)-Synthase / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000378:metabolism*; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D057185:Sedentary Behavior; D013550:Swimming; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D002950:Citrate (si)-Synthase
keywords: cerebrospinal fluid; cytokines; exhaustion; glycogen supercompensation; interleukin-6; strenuous training; swimming