title: Pigment epithelium-derived factor as a new predictor of mortality among chronic kidney disease patients treated with hemodialysis.
abstract: Pigment epithelium-derived factor (PEDF) plays a protective role against atherosclerosis. Although serum PEDF level is increased in patients undergoing regular hemodialysis (HD), the pathophysiological role of PEDF in HD patients is unknown. We measured serum PEDF levels in 74 HD patients, and the association between serum PEDF and adverse events such as all-cause death and cardiovascular accident was evaluated prospectively. During the follow up of 45.4 ± 25.1 months, 24 patients (32.4%) experienced cardiovascular accident and 18 (24.3%) died. Significantly higher incidences of all-cause mortality and cardiovascular accident were observed in the lower PEDF group than in the higher PEDF group. After adjusting for propensity score calculated from multiple confounding factors (age, gender, systolic blood pressure, history of previous cardiovascular disease, level of carbonyl content, albumin, hemoglobin, total cholesterol, creatinine, C-reactive protein, dialysis vintage, Kt/V-urea and history of diabetes), lower predialytic PEDF was a significant risk factor for all-cause mortality (relative hazard = 6.060, standard error = 0.68467, P = 0.0085). Lower levels of predialytic PEDF was associated with an increased risk of mortality.
authors: Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.
authors: Hiroyuki
authors: H
authors: Terawaki
authors: Sho-ichi
authors: S
authors: Yamagishi
authors: Yoichi
authors: Y
authors: Funakoshi
authors: Yukie
authors: Y
authors: Matsuyama
authors: Tomoyoshi
authors: T
authors: Terada
authors: Keisuke
authors: K
authors: Nakayama
authors: Makoto
authors: M
authors: Ogura
authors: Tatsuo
authors: T
authors: Hosoya
authors: Sadayoshi
authors: S
authors: Ito
authors: Seiichi
authors: S
authors: Era
authors: Masaaki
authors: M
authors: Nakayama
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000401:mortality; D015331:Cohort Studies; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D011446:Prospective Studies; D006435:Renal Dialysis / Q000401:mortality*; D051436:Renal Insufficiency, Chronic / Q000401:mortality* / Q000628:therapy; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor
keywords: Cardiovascular disease; Hemodialysis; Mortality; Oxidative stress; Pigment epithelium-derived factor