title: Clinical value of plasma pentraxin 3 levels for predicting cardiac troponin elevation after percutaneous coronary intervention.
abstract: OBJECTIVE
  Post-procedural myocardial necrosis manifested by elevated cardiac troponin T (cTnT) often complicates percutaneous coronary intervention (PCI). Plasma pentraxin 3 (PTX3) levels are increased in patients with arterial inflammation and especially unstable angina pectoris (UAP). This study tested whether plasma PTX3 levels can predict post-PCI cTnT elevation.
  
  
  METHODS
  We evaluated 94 consecutive patients with AP and normal pre-PCI cTnT levels who underwent PCI. Pre-PCI virtual histology-intravascular ultrasound was performed to assess culprit plaque composition. Plasma PTX3 and serum hs-CRP levels were measured pre-PCI. Patients were divided into 2 groups according to presence (Group I, n=34) or absence (Group II, n=60) of post-PCI cTnT elevation >3 × the upper limit of normal at 24h after PCI.
  
  
  RESULTS
  Plasma PTX3 (4.06 ± 2.05 ng/ml vs 2.17 ± 1.02 ng/ml, p<0.001), serum hs-CRP levels (0.25 ± 0.03 vs 0.16 ± 0.03 mg/dl, p=0.048), plaque burden (80.9 ± 5.3 vs 75.4 ± 10.6%, p=0.047), presence of positive remodeling (59 vs 25%, p=0.034), and percent necrotic core area (19.0 ± 7.4 vs 14.0 ± 5.9%, p=0.046) were significantly higher in Group I than in Group II. Receiver-operating characteristic curve analysis showed that with a best cut-off value of 2.83 ng/ml, plasma PTX3 level (AUC 0.823) predicted post-PCI cardiac TnT elevation better than did serum hs-CRP level (AUC 0.618). Multiple logistic regression analysis showed that plasma PTX3 level was the most independent predictor of post-PCI cardiac cTnT elevation (OR: 2.65; 95% CI: 1.56-10.1; p=0.003).
  
  
  CONCLUSIONS
  Plasma PTX3 level may be a useful marker for predicting post-PCI cardiac cTnT elevation, which is associated with inflammatory status of culprit lesions.
authors: Cardiovascular Division, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
authors: Zheng
authors: Z
authors: Wang
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: asato@md.tsukuba.ac.jp.
authors: Akira
authors: A
authors: Sato
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Daiki
authors: D
authors: Akiyama
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Taizo
authors: T
authors: Kimura
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Kazuko
authors: K
authors: Tajiri
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Tomoya
authors: T
authors: Hoshi
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Satoshi
authors: S
authors: Sakai
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Akira
authors: A
authors: Koike
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Takashi
authors: T
authors: Miyauchi
authors: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors: Kazutaka
authors: K
authors: Aonuma
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000473:pathology; D012372:ROC Curve; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D020107:Troponin T / Q000097:blood*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D020107:Troponin T; D000099153:Pentraxins
keywords: Coronary plaque; Pentraxin 3; Troponin; hs-CRP