title: Long-Term Cost-Effectiveness Analysis of Etanercept and Adalimumab for Plaque Psoriasis not Associated with Arthritis.
abstract: BACKGROUND
  Pharmacoeconomic studies examining the cost-effectiveness of biological agents to treat moderate-to-severe psoriasis in real-life clinical practice are scarce. The aim of this study was to assess the efficiency, in terms of incremental cost-effectiveness, of etanercept and adalimumab in a real clinical setting.
  
  
  METHODS
  Direct and indirect costs were assessed from a Spanish societal perspective in a historical hospital cohort of patients with moderate-to-severe psoriasis attending a tertiary referral hospital over a 1-year period. The data examined included drug-related variables, use of health-care resources, transportation and work productivity losses. Effectiveness was measured as the proportion of patients achieving a reduction of at least 75% with respect to the baseline value for the Psoriasis Area Severity Index (PASI 75) during the first 52 weeks of treatment.
  
  
  RESULTS
  No statistically significant differences in effectiveness between etanercept (n = 135) and adalimumab (n = 48) were found (PASI 75 80% vs. 85.7%; RR = 1.07 [0.90, 1.27]; RRA = 5.7 [-8.9, 20.2]; p = 0.943). There were no significant differences in total cost per patient with etanercept as compared to adalimumab (14,843.73 ± 6,178.98 <euro> vs. 15,405.91 ± 9,106.50 <euro>; p = 0.768).
  
  
  CONCLUSIONS
  Under conditions of daily clinical practice in our hospital, total health-care costs associated with the treatment of moderate-to-severe psoriasis with etanercept appear to be equivalent to those with adalimumab in the first year of treatment.
authors: Department of Dermatology, Reina Sofía University Hospital, Avda Menéndez Pidal s/n, 14004, Córdoba, Spain, juanruanoruiz@mac.com.
authors: Juan
authors: J
authors: Ruano
authors: Beatriz
authors: B
authors: Isla-Tejera
authors: Rafael
authors: R
authors: Jiménez-Puya
authors: Ana
authors: A
authors: Rodriguez-Martin
authors: Manuel
authors: M
authors: Cárdenas
authors: Francisco
authors: F
authors: Gómez
authors: A Antonio
authors: AA
authors: Vélez
authors: José R
authors: JR
authors: Del Prado-Llergo
authors: José C
authors: JC
authors: Moreno-Giménez