title: 5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
abstract: BACKGROUND
  Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT(1A)) subtype, in both disorders.
  
  
  OBJECTIVE
  In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
  
  
  RESULTS
  It is difficult to unambiguously distinguish the effects of different populations of the 5-HT(1A) receptors with traditional genetic animal models and pharmacological approaches. However, with the advent of novel genetic systems and subpopulation-selective pharmacological agents, direct evidence for the distinct roles of these populations in governing emotion-related behavior is emerging.
  
  
  CONCLUSIONS
  There is strong and growing evidence for a functional dissociation between auto- and heteroreceptor populations in mediating anxiety and depressive-like behaviors, respectively. Furthermore, while it is well established that 5-HT(1A) receptors act developmentally to establish normal anxiety-like behaviors, the developmental role of 5-HT(1A) heteroreceptors is less clear, and the specific mechanisms underlying the developmental role of each subpopulation are likely to be key elements determining mood control in adult subjects.
authors: Department of Psychiatry, Division of Integrative Neuroscience, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr. Box 87, New York, NY, 10032, USA, ag3149@columbia.edu.
authors: Alvaro L
authors: AL
authors: Garcia-Garcia
authors: Adrian
authors: A
authors: Newman-Tancredi
authors: E David
authors: ED
authors: Leonardo
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D017660:Autoreceptors / Q000235:genetics / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism*; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D017660:Autoreceptors; D018490:Serotonin Agents; D044282:Receptor, Serotonin, 5-HT1A