title: Timely deposition of macromolecular structures is necessary for peer review.
abstract: Most of the macromolecular structures in the Protein Data Bank (PDB), which are used daily by thousands of educators and scientists alike, are determined by X-ray crystallography. It was examined whether the crystallographic models and data were deposited to the PDB at the same time as the publications that describe them were submitted for peer review. This condition is necessary to ensure pre-publication validation and the quality of the PDB public archive. It was found that a significant proportion of PDB entries were submitted to the PDB after peer review of the corresponding publication started, and many were only submitted after peer review had ended. It is argued that clear description of journal policies and effective policing is important for pre-publication validation, which is key in ensuring the quality of the PDB and of peer-reviewed literature.
authors: Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors: Robbie P
authors: RP
authors: Joosten
authors: Hayssam
authors: H
authors: Soueidan
authors: Lodewyk F A
authors: LF
authors: Wessels
authors: Anastassis
authors: A
authors: Perrakis
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D035081:Editorial Policies; D006801:Humans; D010380:Peer Review; D010506:Periodicals as Topic; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: Protein Data Bank; deposition; validation