title: The microenvironment in T-cell lymphomas: emerging themes.
abstract: Peripheral T-cell lymphomas (PTCLs) are heterogeneous and uncommon malignancies characterized by an aggressive clinical course and a mostly poor outcome with current treatment strategies. Despite novel insights into their pathobiology provided by recent genome-wide molecular studies, several entities remain poorly characterized. In addition to the neoplastic cell population, PTCLs have a microenvironment component, composed of non-tumor cells and stroma, which is quantitatively and qualitatively variable, and which may have an effect on their pathological and clinical features. The best example is provided by angioimmunoblastic T-cell lymphoma (AITL), a designation reflecting the typical vascularization and reactive immunoblastic content of the tumor tissues. In this disease, a complex network of interactions between the lymphoma cells and the microenvironment exists, presumably mediated by the neoplastic T cells with follicular helper T-cell properties. A better understanding of the crosstalk between neoplastic T or NK cells and their microenvironment may have important implications for guiding the development of novel therapies.
authors: Department of Pathology, AP-HP, Groupe hospitalier Henri Mondor - Albert Chenevier, Créteil, France; Université Paris-Est, Faculté de Médecine, Créteil, France; INSERM, U955, Institut Mondor de Recherche Biomédicale, Créteil, France. Electronic address: philippe.gaulard@hmn.aphp.fr.
authors: Philippe
authors: P
authors: Gaulard
authors: Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors: Laurence
authors: L
authors: de Leval
mesh_terms: D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics / Q000473:pathology*; D007694:Killer Cells, Natural / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics*
keywords: Angiogenesis; Angioimmunoblastic T-cell lymphoma; Folliclar helper T cell; Macrophages; Microenvironment; T-cell lymphoma