title: Multicellular assembly and light-regulation of cell-cell communication by conjugated polymer materials.
abstract: Using cell-surface modification and biotin-streptavidin interactions, immune cells and target tumor cells are made to form multicellular assemblies. A polythiophene derivative can undergo cellular uptake, allowing the sensitization of oxygen under light irradiation. The subsequent generation of reactive oxygen species (ROS) regulates cell-cell communication in time and space.
authors: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Bing
authors: B
authors: Wang
authors: Jinzhao
authors: J
authors: Song
authors: Huanxiang
authors: H
authors: Yuan
authors: Chenyao
authors: C
authors: Nie
authors: Fengting
authors: F
authors: Lv
authors: Libing
authors: L
authors: Liu
authors: Shu
authors: S
authors: Wang
mesh_terms: D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D006801:Humans; D019169:Jurkat Cells; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D008027:Light; D018613:Microscopy, Confocal; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding; D019809:Streptavidin / Q000737:chemistry / Q000378:metabolism; D013876:Thiophenes / Q000737:chemistry
chemical_list: D011108:Polymers; D013876:Thiophenes; C066730:polythiophene; D001710:Biotin; D019809:Streptavidin
keywords: anticancer materials; biomedical applications; conjugated polymers; surface modification