title: 5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation.
abstract: 5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition of 5-LO. In this review, we summarize the established dogma and recent progress on the biochemical and pharmacological regulation of 5-LO and its diverse cellular partners. In the last decade, significant research efforts have led to the exploitation of 5-LO pathway for developing new drugs against inflammatory diseases. Despite few setbacks, a number of promising molecules have moved into clinical development. These fundamental discoveries and proof-of-concept studies will ultimately be helpful in delineating how 5-LO pathway participates in the development of disease phenotype and what are possible key biomarkers of disease progression and regression. Elucidation of molecular mechanism-of-action of 5-LO in individual cell types will pave the way for improving efficacy parameters. Taken together, this combined knowledge about the 5-LO pathway would be helpful in planning collaborative and targeted R&D efforts, by the academic laboratories and pharmaceutical/ biotech industry, for the discovery and development of novel, efficacious and safer drugs against multiple diseases.
authors: Yasir
authors: Y
authors: Anwar
authors: Jamal S M
authors: JS
authors: Sabir
authors: Muhammad I
authors: MI
authors: Qureshi
authors: Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia. ksaini@kau.edu.sa.
authors: Kulvinder S
authors: KS
authors: Saini
mesh_terms: D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D015415:Biomarkers; D016859:Lipoxygenase Inhibitors; D001094:Arachidonate 5-Lipoxygenase