title: Effects of endogenous regulators of endothelial NO synthase on nitric oxide homeostasis and blood serum lipoproteins during experimental diabetes mellitus.
abstract: Experimental diabetes mellitus was associated with the development of oxidative stress and a decrease in blood concentration of total nitric oxide (NO) metabolites. Administration of L-arginine induced positive changes in the LPO-antioxidant enzyme system and elevated NO concentration in blood serum, whereas L-NAME, inhibitor of eNOS (NOS-III) increased LPO intensity via SOD inhibition and reduced NO content. Combined administration of Q10 and L-arginine led the suppression of oxidative stress and significant increase in NO level. Combined treatment with Q10 and L-NAME partly abolished the effects of the inhibitor on the parameters of the LPO-antioxidant enzyme system and NO concentration. In all variants of the study, Q10 stimulated eNOS expression and increases NO bioavailability by reducing the levels of total cholesterol and LDL and increasing HDL content in blood serum.
authors: Institute of Biomedical Studies, Vladikavkaz Research Center, Russian Academy of Sciences and Government of the Republic of North Ossetia-Alania, Vladikavkaz; National Research Center of Preventive Medicine, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. biohimik-bog@mail.ru.
authors: S G
authors: SG
authors: Dzugkoev
authors: V A
authors: VA
authors: Metel'skaya
authors: F S
authors: FS
authors: Dzugkoeva
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage; D009569:Nitric Oxide / Q000097:blood*; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D001120:Arginine; D002784:Cholesterol; D006442:Glycated Hemoglobin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase; D014451:Ubiquinone; C496316:Nos3 protein, rat; C024989:coenzyme Q10