title: Potential use of hyperoxygenated solution as a treatment strategy for carbon monoxide poisoning.
abstract: OBJECTIVE
  Carbon monoxide (CO) poisoning can cause permanent damage in tissues that are sensitive to hypoxia. We explored the feasibility and efficacy of using a hyperoxygenated solution (HOS) to treat severe acute CO poisoning in an animal model.
  
  
  METHODS
  Male Sprague-Dawley rats were subjected to CO poisoning. The HOS was administered into the femoral vein of these rats through a catheter (10 ml/kg). Carboxyhemoglobin (COHb) and blood gases were used to assess the early damage caused by CO poisoning. S100β was measured to predict the development of late cognitive sequelae of CO. The Morris water maze test was performed to assess cognitive function, and Nissl staining was performed to observe histologic change.
  
  
  RESULTS
  The COHb concentrations rapidly decreased at 5 min after the HOS administration; however, the PaO2 and SaO2 in rats treated with HOS increased significantly 5 min after the HOS administration. The S100β concentrations, which increased significantly after CO poisoning, increased at a much slower rate in the rats treated with HOS (HOS group) compared with the rats treated with O2 inhalation (O2 group). The escape latency in the place navigation test was shortened after CO poisoning on days 11-15 and days 26-30, and the swimming time in quadrant 4 in the spatial probe test on days 15 and 30 after CO poisoning was prolonged in the rats treated with HOS injection compared with the rats treated with oxygen inhalation or normal saline injection. The neuronal degeneration in the HOS group was alleviated than that in the CO or O2 group.
  
  
  CONCLUSIONS
  HOS efficiently alleviates the brain damage in acute CO-poisoned rats and thus may serve as a new way to treat human patients with CO poisoning in clinical practice.
authors: Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
authors: Xingxing
authors: X
authors: Sun
authors: Hao
authors: H
authors: Xu
authors: Xiangzhong
authors: X
authors: Meng
authors: Jian
authors: J
authors: Qi
authors: Yuanyuan
authors: Y
authors: Cui
authors: Yunqing
authors: Y
authors: Li
authors: Hui
authors: H
authors: Zhang
authors: Lixian
authors: L
authors: Xu
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002263:Carboxyhemoglobin / Q000378:metabolism; D002540:Cerebral Cortex / Q000473:pathology; D005240:Feasibility Studies; D006624:Hippocampus / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010100:Oxygen / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism; D012996:Solutions; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit; D012996:Solutions; D002263:Carboxyhemoglobin; D010100:Oxygen