title: Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period.
abstract: BACKGROUND
  Human Enterovirus 71 and Coxsackie A16 have caused many outbreaks in the last decade in mainland China, resulting in thousands of fatal cases. Seroepidemiology which provides important information to document population immunity is rare in China.
  
  
  RESULTS
  A cross sectional study of Enterovirus 71 (EV71) and Coxsackie A16 (CA16) seroprevalence was carried out in Guangdong, China, pre- and post- the 2010 hand, foot and mouth disease (HFMD) epidemic period. The levels of EV71 and CA16 specific antibodies were evaluated by a microneutralization test and the geometric mean titer (GMT) was calculated and compared. Our results indicated frequent infection by EV71 and CA16 in Guangdong before the 2010 epidemic. Only EV71 neutralizing antibody but not CA16 seroprevalence was significantly increased after the 2010 HFMD epidemic. Children less than 3 years old especially those aged 2 years showed the lowest positive rates for EV71 and CA16 NA before epidemic and the most significantly increased EV71 seroprevalence after epidemic. CA16 GMT values declined after the 2010 epidemic.
  
  
  CONCLUSIONS
  These results indicate EV71 was the major pathogen of HFMD in Guangdong during the 2010 epidemic. The infection occurs largely in children less than 3 years, who should have first priority to receive an EV71 vaccine.
authors: Center of Pathogen Detection Research for Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China ; Key Laboratory of Pathogen Detection for Emergency Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China ; Key Laboratory of Depository and Application for Pathogenic Microbiology, Guangdong Provincial Centre for Disease Control and Prevention, Guangzhou, China.
authors: Wei
authors: W
authors: Li
authors: Lina
authors: L
authors: Yi
authors: Juan
authors: J
authors: Su
authors: Jing
authors: J
authors: Lu
authors: Changwen
authors: C
authors: Ke
authors: Hanri
authors: H
authors: Zeng
authors: Dawei
authors: D
authors: Guan
authors: Cong
authors: C
authors: Ma
authors: Wanly
authors: W
authors: Zhang
authors: Hong
authors: H
authors: Xiao
authors: Hui
authors: H
authors: Li
authors: Jinyan
authors: J
authors: Lin
authors: Yonghui
authors: Y
authors: Zhang
mesh_terms: D000328:Adult; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D007223:Infant; D008297:Male; D016036:Seroepidemiologic Studies
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral