title: Reactive angioendotheliomatosis associated with cyroglobulinemia in a marathon runner.
abstract: We report a case of a 65-year-old marathon runner who presented with painful plaques, which were worse in cold weather and progressed to ulceration. A punch biopsy revealed vascular endothelial hyperplasia and an appearance consistent with reactive angioendotheliomatosis (RAE), a rare, but benign disorder of the skin. Subsequent investigations resulted in the diagnosis of type I cryoglobulinemia; the lesions resolved completely following treatment of the underlying disorder with lenalidomide.
authors: Austin Hospital.
authors: Ann
authors: A
authors: Boyapati
authors: Sant
authors: S
authors: Khan
authors: Adrian
authors: A
authors: Mar
authors: Adam
authors: A
authors: Sheridan
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D003449:Cryoglobulinemia / Q000150:complications* / Q000175:diagnosis; D006390:Hemangioendothelioma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D012420:Running; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D013792:Thalidomide; D000077269:Lenalidomide