title: Total synthesis of the marine alkaloid Mansouramycin D.
abstract: Mansouramycin D, a cytotoxic alkaloid was isolated from a marine Streptomyces sp. in 2009. The first, simple, and concise route to the total synthesis of Mansouramycin D is reported. The core structure of the isoquinoline ring has been constructed from iminoannulation of 2-alkynylbenzaldehyde followed by oxidation/deprotection and oxidative amination via a three-step sequence from easily accessible starting materials.
authors: School of Chemistry, University of Hyderabad , Hyderabad-500 046, India.
authors: K S
authors: KS
authors: Prakash
authors: Rajagopal
authors: R
authors: Nagarajan
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C546300:3-(1H-indol-3-yl)-7-methylaminoisoquinoline-5,8-dione; D000470:Alkaloids; D007546:Isoquinolines