title: Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study.
abstract: OBJECTIVE
  The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate.
  
  
  BACKGROUND
  Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds.
  
  
  METHODS
  Excisional biopsy was performed in oral soft tissues with a potassium-titanyl-phosphate (KTP) laser (532 nm, SmartLite, DEKA, Florence, Italy) in 49 patients divided into two groups. In the study group (SG), 31 patients received a compound gel containing four amino acids and sodium hyaluronate (Aminogam(®), Errekappa, Italy) after laser surgery; in the control group (CG), 18 subjects received no treatment involving a drug or gel. Numeric rating scale (NRS) was used to evaluate pain experienced after surgery [pain index (PI)]. Using a grid as a benchmark and computer software, the lesion area was measured after surgery (T0) and after 7 days (T1). A percentage healing index (PHI) was calculated indicating healing extension in 7 days.
  
  
  RESULTS
  SG cases showed an average PHI of 64.38±26.50, whereas the average PHI in the CG was 47.88%±27.84. Mean PI was 2.67±0.96 for SG and 2.75±0.86 for CG. A statistically significant difference was detected between the groups for PHI (p=0.0447), whereas no difference was detectable for PI (p=0.77).
  
  
  CONCLUSIONS
  The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.
authors: Department of Oral Sciences, "Sapienza" University of Rome , Rome, Italy .
authors: Umberto
authors: U
authors: Romeo
authors: Fabrizio
authors: F
authors: Libotte
authors: Gaspare
authors: G
authors: Palaia
authors: Alexandros
authors: A
authors: Galanakis
authors: Gianfranco
authors: G
authors: Gaimari
authors: Gianluca
authors: G
authors: Tenore
authors: Alessandro
authors: A
authors: Del Vecchio
authors: Antonella
authors: A
authors: Polimeni
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000601:surgery*; D010147:Pain Measurement; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D006820:Hyaluronic Acid