title: Lactose as a "Trojan horse" for quantum dot cell transport.
abstract: A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK).
authors: David
authors: D
authors: Benito-Alifonso
authors: Shirley
authors: S
authors: Tremel
authors: Bo
authors: B
authors: Hou
authors: Harriet
authors: H
authors: Lockyear
authors: Judith
authors: J
authors: Mantell
authors: David J
authors: DJ
authors: Fermin
authors: Paul
authors: P
authors: Verkade
authors: Monica
authors: M
authors: Berry
authors: M Carmen
authors: MC
authors: Galan
mesh_terms: D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007785:Lactose / Q000737:chemistry / Q000378:metabolism*; D018613:Microscopy, Confocal; D011134:Polysaccharides / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity
chemical_list: D011134:Polysaccharides; D007785:Lactose
keywords: glycans; intracellular localization; multivalency; nanoparticles; quantum dots