title: Mesoporous silicon microparticles enhance MHC class I cross-antigen presentation by human dendritic cells.
abstract: The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.
authors: EM-Silicon Nano-Technologies SL, Nat. R. Cisternas 8, 46010 Valencia, Spain.
authors: A
authors: A
authors: Jiménez-Periáñez
authors: B
authors: B
authors: Abos Gracia
authors: J
authors: J
authors: López Relaño
authors: C M
authors: CM
authors: Diez-Rivero
authors: P A
authors: PA
authors: Reche
authors: E
authors: E
authors: Martínez-Naves
authors: E
authors: E
authors: Matveyeva
authors: M
authors: M
authors: Gómez del Moral
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology; D017610:Calcium Compounds / Q000737:chemistry; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D000939:Epitopes / Q000008:administration & dosage / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D010446:Peptide Fragments / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D017640:Silicates / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000956:Antigens, Viral; D017610:Calcium Compounds; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D010446:Peptide Fragments; D017640:Silicates; C031293:calcium silicate