title: Regulation of β-cell function by RNA-binding proteins.
abstract: β-cells of the pancreatic islets are highly specialized and high-throughput units for the production of insulin, the key hormone for maintenance of glucose homeostasis. Elevation of extracellular glucose and/or GLP-1 levels triggers a rapid upregulation of insulin biosynthesis through the activation of post-transcriptional mechanisms. RNA-binding proteins are emerging as key factors in the regulation of these mechanisms as well as in other aspects of β-cell function and glucose homeostasis at large, and thus may be implicated in the pathogenesis of diabetes. Here we review current research in the field, with a major emphasis on RNA-binding proteins that control biosynthesis of insulin and other components of the insulin secretory granules by modulating the stability and translation of their mRNAs.
authors: Molecular Diabetology, Paul Langerhans Institute Dresden, TU Dresden ; German Center for Diabetes Research (DZD e.V.), Fetscherstrasse 74, 01307 Dresden, Germany.
authors: Maria Grazia
authors: MG
authors: Magro
authors: Michele
authors: M
authors: Solimena
keywords: Diabetes; Insulin; RNA-binding proteins; Translation; mRNA stability; β-cells