title: A rare case of peritoneal disseminated angiosarcoma 20 years after ovarian cancer diagnosis.
abstract: Angiosarcoma is a rare form of sarcoma which may be either a primary tumor or it may result from previous irradiation because of another tumor. In this paper, we present a case of a female patient diagnosed as having peritoneal disseminated angiosarcoma 20 years after ovarian cancer treatment (surgery, chemotherapy and radiotherapy). The case was very atypical because of an extremely rare peritoneal location and disseminated nature of the changes. Based on the initial histological picture, poorly differentiated cancer metastasis was diagnosed, suggesting a recurrence of the ovarian cancer that had been diagnosed earlier. The time elapsed from the ovarian cancer diagnosis, history of the previous irradiation and concentration of tumor markers were the only additional clinical data provided to the pathologists, which ultimately contributed to a correct diagnosis. The case we present herein shows and emphasizes the importance of proper communication between a clinician and a pathologist, which is a prerequisite for a correct diagnosis and, consequently, for proper treatment of patients. It also confirms the high specificity of the HE4 (human epididymis protein 4) marker in the monitoring of ovarian cancer, which was within normal limits in spite of peritoneal tumor dissemination.
authors: Departments of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
authors: Anita
authors: A
authors: Chudecka-Głaz
authors: Janusz
authors: J
authors: Menkiszak
authors: Sławomir
authors: S
authors: Kuźniak
authors: Magdalena
authors: M
authors: Lewandowska
authors: Mirosław
authors: M
authors: Burak
authors: Anna
authors: A
authors: Walecka
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human