title: Primary glioblastoma of the medulla spinalis: a report of three cases and review of the literature.
abstract: Primary spinal glioblastoma multiforme (spinal GBM) is not a very common entity. This paper presents an outline of this rare neoplasm, its clinical presentation, course, management and outcome and reports a 3-case series of spinal GBM. In this 3-case series with spinal GBM, one of the patients was operated for hydrocephalous 10 months later following the tumor surgery and another patient had cerebral metastasis after the surgery. In the postoperative period, two of the cases received radiotherapy and one received combined radiotherapy and chemotherapy with steroid therapy together following the tumor surgery. The review of the pertinent literature has revealed that due to the scarcity of the reported cases of primary spinal GBMs, this issue requires a closer look. GBM behaves more aggressive in medulla spinalis than it behaves when it originates from cerebrum. It may disseminate to the cerebrum during its course and it may cause hydrocephalus due to this dissemination (metastasis).
authors: Ege University, Faculty of Medicine, Department of Neurosurgery, Izmir, Turkey.
authors: Erkin
authors: E
authors: Ozgiray
authors: Ali
authors: A
authors: Akay
authors: Yesim
authors: Y
authors: Ertan
authors: Sedat
authors: S
authors: Cagli
authors: Nezih
authors: N
authors: Oktar
authors: Nurcan
authors: N
authors: Ozdamar
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007150:Immunohistochemistry; D017116:Low Back Pain / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010292:Paresthesia / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000601:surgery*; D013256:Steroids / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013256:Steroids