title: Synthesis of a novel molecularly imprinted organic-inorganic hybrid polymer for the selective isolation and determination of fluoroquinolones in tilapia.
abstract: A novel molecularly imprinted organic-inorganic hybrid polymer (MI-MAA/APTS) based on a dummy molecular imprinting technique and an organic-inorganic hybrid material technique was synthesised and used as a sorbent in solid-phase extraction for the selective isolation and determination of ofloxacin (OFL), lomefloxacin (LOM), and ciprofloxacin (CIP) in tilapia samples. The MI-MAA/APTS sorbent was prepared from 3-aminopropyltriethoxysilanes (APTS) as an inorganic source and methacrylic acid (MAA) as an organic source and exhibited high mechanical strength and special affinities to the analytes. A comparison of MI-MAA/APTS with other conventional sorbents (C18 and HLB) showed that MI-MAA/APTS displayed good selectivity and affinity for OFL, LOM, and CIP, and the recoveries of the analytes at three spiked levels were in the range of 85.1-101.0%, with the relative standard deviations ≤5.1%. The presented MI-MAA/APTS-SPE-HPLC method could be potentially applied to the determination of fluoroquinolones (FQs) in complex fish samples.
authors: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China.
authors: Xun
authors: X
authors: Yang
authors: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China.
authors: Ruiling
authors: R
authors: Wang
authors: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China.
authors: Weihua
authors: W
authors: Wang
authors: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China. Electronic address: yanhy@hbu.edu.cn.
authors: Hongyuan
authors: H
authors: Yan
authors: Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
authors: Mande
authors: M
authors: Qiu
authors: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China.
authors: Yanxue
authors: Y
authors: Song
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D024841:Fluoroquinolones / Q000032:analysis* / Q000302:isolation & purification; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods; D017210:Tilapia / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011108:Polymers
keywords: Fluoroquinolones; Molecular imprinting; Organic–inorganic hybrid materials; Solid-phase extraction; Tilapia