title: Room-temperature Pd-catalyzed C-H chlorination by weak coordination: one-pot synthesis of 2-chlorophenols with excellent regioselectivity.
abstract: A room-temperature Pd(II)-catalyzed regioselective chlorination reaction has been developed for a facile one-pot synthesis of a broad range of 2-chlorophenols. The reaction demonstrates an excellent regioselectivity and reactivity for C-H chlorination. This reaction represents one of the rare examples of mild C-H functionalization at ambient temperature.
authors: MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors: Xiuyun
authors: X
authors: Sun
authors: Yonghui
authors: Y
authors: Sun
authors: Chao
authors: C
authors: Zhang
authors: Yu
authors: Y
authors: Rao
mesh_terms: D002713:Chlorine / Q000737:chemistry*; D002733:Chlorophenols / Q000138:chemical synthesis / Q000737:chemistry*; D054879:Halogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D002733:Chlorophenols; D002713:Chlorine; D010165:Palladium; C030683:2-chlorophenol