title: Delivery of intrahemocoelic peptides for insect pest management.
abstract: The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest management, a diverse range of insect-specific insecticidal peptides remains an untapped resource for pest management efforts. These toxins act within the insect hemocoel (body cavity) and hence require a delivery system to access their target site. Here, we summarize recent developments for appropriate delivery of such intrahemocoelic insect toxins, via fusion to a second protein such as a plant lectin or a luteovirus coat protein for transcytosis across the gut epithelium, or via entomopathogenic fungi.
authors: Department of Entomology, Iowa State University, Ames, IA 50011, USA. Electronic address: bbonning@iastate.edu.
authors: Bryony C
authors: BC
authors: Bonning
authors: Department of Entomology, Iowa State University, Ames, IA 50011, USA.
authors: Nanasaheb P
authors: NP
authors: Chougule
mesh_terms: D000818:Animals; D005656:Fungal Proteins / Q000493:pharmacokinetics*; D007313:Insecta / Q000187:drug effects*; D007306:Insecticides / Q000493:pharmacokinetics*; D007413:Intestinal Mucosa / Q000378:metabolism; D010571:Pest Control / Q000379:methods*; D057900:Transcytosis
chemical_list: D005656:Fungal Proteins; D007306:Insecticides
keywords: lectin; luteovirus coat protein; neuropeptide; neurotoxin; transcytosis