title: Immune ambivalence: The schizophrenic bleomycin.
abstract: In addition to cytotoxic effects, anticancer agents can exert multiple immunomodulatory functions. We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+T cell responses; and 2) induce the secretion of transforming growth factor β (TGFβ), which stimulates regulatory T cells. This suggests that bleomycin may be favorably combined with TGFβ-targeting strategies.
authors: INSERM, U866; Dijon, France ; INSERM, AVENIR Team; Dijon, France ; Faculté de Médecine; Université de Bourgogne; Dijon, France.
authors: Grégoire
authors: G
authors: Mignot
authors: Hélène
authors: H
authors: Bugaut
authors: François
authors: F
authors: Ghiringhelli
keywords: bleomycine; immunogenic cell death; mouse study; regulatory T cells; transforming growth factor beta