title: [The effects of gastric bypass procedures on blood glucose, gastric inhibitory polypeptide and glucagon-like peptide-1 of normal glucose tolerance dogs].
abstract: OBJECTIVE
  To observe postoperative glucose tolerance, gastric inhibitory polypeptide (GIP) , and glucogan-like peptide-1 (GLP-1) in normal glucose level dogs after undergoing gastric bypass procedures, and to explore the mechanism of gastric bypass procedures to treat type 2 diabetes.
  
  
  METHODS
  The 6 dogs with normal glucose tolerance had undergone gastric bypass procedures, and measure preoperative and postoperative oral and intravenous glucose tolerance (at time points 1, 2, and 4 weeks) through changes in blood glucose, insulin, gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and measure preoperative and postoperative week 4 pancreatic tissue morphology.
  
  
  RESULTS
  Second weeks after operation, the fasting blood sugar was (3.58 ± 0.33) mmol/L, and significantly lower than preoperative (t = 3.571, P < 0.05). The GLP-1 level before oral glucose tolerance test (OGTT) and 30 minutes after OGTT were (0.90 ± 0.21) and (0.91 ± 0.19) pmol/L respectively, and significantly higher than preoperative (t value were -3.660 and -2.971, P < 0.05). GLP-1 levels began to decrease in the second week after surgery. After 4 weeks, the index recovered to the preoperative level. Four weeks after surgery when compared with preoperative, islet morphology, islet number (6.8 ± 0.8 and 7.1 ± 0.8 respectively) and islet cells (16.7 ± 2.5 and 16.3 ± 3.1 respectively) did not change significantly (P > 0.05).
  
  
  CONCLUSIONS
  Gastric bypass procedures could be briefly affect normal glucose tolerance in dogs' blood glucose, insulin and diabetes-related gastrointestinal hormones.
authors: Department of General Surgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
authors: Li-Zhen
authors: LZ
authors: Pan
authors: Ri-Xing
authors: RX
authors: Bai
authors: Email: smaomin@sina.com.
authors: Mao-Min
authors: MM
authors: Song
authors: You-Guo
authors: YG
authors: Li
authors: Lisa
authors: L
authors: Zhou
authors: Zhi-Qiang
authors: ZQ
authors: Zhong
authors: Jun
authors: J
authors: Xu
authors: Hui-Sheng
authors: HS
authors: Yuan
authors: Zhen
authors: Z
authors: Cui
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D004285:Dogs; D015390:Gastric Bypass; D005749:Gastric Inhibitory Polypeptide; D005934:Glucagon; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D005947:Glucose; D007328:Insulin / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D005947:Glucose