title: Preparation and In vitro Investigation of Chitosan Compressed Tablets for Colon Targeting.
abstract: OBJECTIVE
  The aim of the present study was minimizing the drug release in upper gastro intestinal tract and targeting to colon by using the principles of compression coat.
  
  
  METHODS
  Compression coated tablets of Ibuprofen were prepared by direct compression method using chitosan (300, 250, 200 & 175 mg). Tablets were evaluated for their physicochemical properties and in vitro drug release studies. In vitro drug release studies were performed with and without rat caecal contents.
  
  
  RESULTS
  In the rat caecal contents tablets showed enhanced drug release due to degradation of chitosan coat by colonic colonic enzymes. The in vitro release studies in pH-6.8 phosphate buffer containing 2% w/v of rat caecal contents showed the cumulative percentage release of Ibuprofen after 26h as 31.94% ±0.59, 67.89% ± 0.45 and 55.87 % ± 0.45 and 82.52 % ± 0.92 respectively. Coat thickness and amount of chitosan controls the release rate. Formulations are best fitted with Korsmeyer-Peppas kinetics and mechanism of drug release was non-Fickian. FTIR studies reveals there is no drug-polysaccharide interaction. F1 formulation was a promising system for drug targeting to colon.
  
  
  CONCLUSIONS
  Based on the obtained results chitosan as a press coat could target ibuprofen to the colon.
authors: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore - 560078, Karnataka,India ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Negar
authors: N
authors: Bashardoust
authors: Josephine Leno
authors: JL
authors: Jenita
authors: Parvin
authors: P
authors: Zakeri-Milani
keywords: Chitosan; Colon targeting; Compressed coated; Ibuprofen; Polysaccharide; Tablet