title: Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate.
abstract: Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using cells derived from a patient's own cells. However, the immunogenicity of iPSCs or their derivatives has been a matter of controversy, and up to now there has been no direct comparison of autologous and allogeneic transplantation in the brains of humans or nonhuman primates. Here, using nonhuman primates, we found that the autologous transplantation of iPSC-derived neurons elicited only a minimal immune response in the brain. In contrast, the allografts caused an acquired immune response with the activation of microglia (IBA-1(+)/MHC class II(+)) and the infiltration of leukocytes (CD45(+)/CD3(+)). Consequently, a higher number of dopaminergic neurons survived in the autografts. Our results suggest that the autologous transplantation of iPSC-derived neural cells is advantageous for minimizing the immune response in the brain compared with allogeneic grafts.
authors: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
authors: Asuka
authors: A
authors: Morizane
authors: Daisuke
authors: D
authors: Doi
authors: Tetsuhiro
authors: T
authors: Kikuchi
authors: Keisuke
authors: K
authors: Okita
authors: Akitsu
authors: A
authors: Hotta
authors: Toshiyuki
authors: T
authors: Kawasaki
authors: Takuya
authors: T
authors: Hayashi
authors: Hirotaka
authors: H
authors: Onoe
authors: Takashi
authors: T
authors: Shiina
authors: Shinya
authors: S
authors: Yamanaka
authors: Jun
authors: J
authors: Takahashi
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology; D002454:Cell Differentiation; D057026:Induced Pluripotent Stem Cells / Q000276:immunology / Q000378:metabolism / Q000637:transplantation*; D008252:Macaca fascicularis; D008285:Major Histocompatibility Complex / Q000276:immunology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D019737:Transplants / Q000276:immunology*