title: Liver transplantation in children weighing less than 10 kg: Chilean experience.
abstract: BACKGROUND
  Orthotopic liver transplantation is the treatment of choice for most terminal liver diseases in children. In small children (≤ 10 kg), this procedure is challenging and has special considerations. The aim of this study is to describe the experience of a Chilean liver transplantation program in this subgroup of patients.
  
  
  METHODS
  The liver transplant database of Hospital Luis Calvo Mackenna and Clinica Las Condes was reviewed. All children less than 10 kg undergoing liver transplantation between January 1994 and July 2011 were included. Patient and graft outcomes and main complications were analyzed.
  
  
  RESULTS
  We have performed 230 pediatric liver transplantations, 49 of them in 41 patients weighing less than 10 kg. The first indication for transplantation was biliary atresia in 25 patients (61%). A living related donor was used in 23 cases (51%). Actuarial survival was 75.7% at 1 year and 67.1% at 5 years. The main cause of death was infection, and the leading cause of graft loss was vascular complication.
  
  
  CONCLUSIONS
  Our transplant program includes 2 centers that perform more than 90% of pediatric liver transplantations in Chile, including public health pediatric patients from all around the country. Patients weighing less than 10 kg represent the most challenging group in pediatric liver transplantation due to higher rates of vascular and biliary complications and postoperative infections.
authors: Hospital Luis Calvo Mackenna, Santiago, Chile. Electronic address: muribem@clc.cl.
authors: M
authors: M
authors: Uribe
authors: A
authors: A
authors: Alba
authors: B
authors: B
authors: Hunter
authors: G
authors: G
authors: González
authors: J
authors: J
authors: Godoy
authors: M
authors: M
authors: Ferrario
authors: E
authors: E
authors: Buckel
authors: S
authors: S
authors: Cavallieri
authors: C
authors: C
authors: Heine
authors: R
authors: R
authors: Rebolledo
authors: H
authors: H
authors: Auad
authors: C
authors: C
authors: Acuña
mesh_terms: D000367:Age Factors; D001835:Body Weight; D002677:Chile; D003141:Communicable Diseases / Q000209:etiology / Q000401:mortality; D003430:Cross-Sectional Studies; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000401:mortality; D006085:Graft Survival; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D019520:Living Donors; D008297:Male; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome