title: Functional respiratory imaging as a tool to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis.
abstract: A completely different treatment approach was chosen for 2 patients with unilateral diaphragmatic paralysis and complaints of dyspnea despite similar anatomic and physiologic abnormalities. These decisions were supported by results obtained by functional respiratory imaging (FRI). FRI generated functional information on lobar ventilation and local drug deposition. In the first patient, some lobes were poorly ventilated, and drug deposition simulation showed that some regions were undertreated. This patient underwent diaphragmatic plication to restore ventilation. In the second patient, all lobes were still ventilated. A conservative approach with regular follow-ups was chosen to wait for spontaneous recovery of the diaphragmatic function. Both patients improved subjectively and objectively. These cases demonstrate how novel medical imaging techniques such as FRI can be used to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis.
authors: Fluidda nv, Kontich, Belgium. cedric.vanholsbeke@fluidda.com.
authors: Cedric S
authors: CS
authors: Van Holsbeke
authors: Department of Respiratory Medicine Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk (Antwerpen), Belgium.
authors: Glenn
authors: G
authors: Leemans
authors: Fluidda nv, Kontich, Belgium.
authors: Wim G
authors: WG
authors: Vos
authors: Fluidda nv, Kontich, Belgium.
authors: Jan W
authors: JW
authors: De Backer
authors: Fluidda nv, Kontich, Belgium.
authors: Samir C
authors: SC
authors: Vinchurkar
authors: Department of Radiology, Antwerp University Hospital, Antwerpen, Belgium.
authors: Michel
authors: M
authors: Geldof
authors: bioMMeda, Ghent University, Ghent, Belgium.
authors: Pascal R
authors: PR
authors: Verdonck
authors: Department of Radiology, Antwerp University Hospital, Antwerpen, Belgium. Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk (Antwerpen), Belgium.
authors: Paul M
authors: PM
authors: Parizel
authors: Department of Thoracic and Vascular Surgery Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk (Antwerpen), Belgium.
authors: Paul E
authors: PE
authors: Van Schil
authors: Department of Respiratory Medicine Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk (Antwerpen), Belgium.
authors: Wilfried A
authors: WA
authors: De Backer
mesh_terms: D001993:Bronchodilator Agents / Q000493:pharmacokinetics*; D003964:Diaphragm / Q000601:surgery; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D057285:Precision Medicine; D012123:Pulmonary Ventilation; D012133:Respiratory Paralysis / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D001993:Bronchodilator Agents
keywords: MeSH; computer-assisted decision making; diaphragmatic paralysis; personalized medicine; pulmonary ventilation; respiratory drug administration; thoracic surgery