title: A novel bullet hits the proteasome.
abstract: An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessential for proteasome function in most normal tissues, but is overexpressed in many solid tumors.
authors: Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address: alexei.f.kisselev@dartmouth.edu.
authors: Alexei F
authors: AF
authors: Kisselev
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000188:drug therapy*; D010881:Piperidones / Q000494:pharmacology*; D061988:Proteasome Inhibitors / Q000494:pharmacology*
chemical_list: C500781:ADRM1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D010881:Piperidones; D061988:Proteasome Inhibitors