title: The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.
abstract: Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.
authors: Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California at Davis, Davis, CA 95616, USA. Electronic address: jbhahm@ucdavis.edu.
authors: Johnnie B
authors: JB
authors: Hahm
authors: Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California at Davis, Davis, CA 95616, USA. Electronic address: acshroeder@ucdavis.edu.
authors: Amy C
authors: AC
authors: Schroeder
authors: Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California at Davis, Davis, CA 95616, USA. Electronic address: mlprivalsky@ucdavis.edu.
authors: Martin L
authors: ML
authors: Privalsky
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D057809:HEK293 Cells; D006801:Humans; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D025941:Protein Interaction Mapping; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D061987:Sf9 Cells; D015398:Signal Transduction; D018411:Spodoptera; D037021:Thyroid Hormone Receptors alpha / Q000235:genetics* / Q000378:metabolism; D037042:Thyroid Hormone Receptors beta / Q000235:genetics* / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D011993:Recombinant Fusion Proteins; D037021:Thyroid Hormone Receptors alpha; D037042:Thyroid Hormone Receptors beta; D008156:Luciferases
keywords: Coactivators; Corepressors; Isoforms; Nuclear receptor partner proteins; Thyroid hormone receptors; Transcriptional regulation