title: Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30.
abstract: OBJECTIVE
  To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients.
  
  
  METHODS
  Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30).
  
  
  RESULTS
  Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. In the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. In patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL.
  
  
  CONCLUSIONS
  Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.
authors: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
authors: Gemma
authors: G
authors: Cramarossa
authors: Liang
authors: L
authors: Zeng
authors: Liying
authors: L
authors: Zhang
authors: Ling-Ming
authors: LM
authors: Tseng
authors: Ming-Feng
authors: MF
authors: Hou
authors: Alysa
authors: A
authors: Fairchild
authors: Vassilios
authors: V
authors: Vassiliou
authors: Reynaldo
authors: R
authors: Jesus-Garcia
authors: Mohamed A
authors: MA
authors: Alm El-Din
authors: Aswin
authors: A
authors: Kumar
authors: Fabien
authors: F
authors: Forges
authors: Wei-Chu
authors: WC
authors: Chie
authors: Arjun
authors: A
authors: Sahgal
authors: Henry
authors: H
authors: Lam
authors: Natalie
authors: N
authors: Pulenzas
authors: Edward
authors: E
authors: Chow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary; D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology; D005260:Female; D014943:Global Health; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011788:Quality of Life; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D055815:Young Adult