title: Analgesic activity of some 1,2,4-triazole heterocycles clubbed with pyrazole, tetrazole, isoxazole and pyrimidine.
abstract: OBJECTIVE
  In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated.
  
  
  METHODS
  Acetic acid induced writhing method and Hot plate method has been described to study analgesic activity of some 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine as a pharmacological active lead.
  
  
  RESULTS
  Thirty six different derivatives containing 1,2,4-triazole ring were subjected to study their in vivo analgesic activity. Chloro, nitro and methoxy, hydroxy and bromo substituted derivatives showed excellent analgesic activity and dimethylamino, furan and phenyl substituted derivatives showed moderate analgesic activity in both of the methods. Compounds IIIa, IIId, IIIf, IIIi, IIIj, IVa, IVb, IVd, IVf, IVh, IVj IV3a and IIj were found to be superior analgesic agents after screening by Acetic acid induced writhing method. Compounds IIIb, IIId, IIIf, IIIh, IIIj, IVa, IVb, IVd, IVf, IVh, IVi, IV3c, IV3e and IIj were showed analgesic potential after screening of Hot plate method.
  
  
  CONCLUSIONS
  All tested compounds containing 1,2,4-triazole were found to be promising analgesic agents, for this activity pyrazole, tetrazole, isoxazole and pyrimidine leads might be supported.
authors: Research scholar, Department of Pharmacy, Vinayaka Missions University, Salem, Sankari main road, NH-47, Tamilnadu, India-636308.
authors: Shantaram
authors: S
authors: Gajanan Khanage
authors: Appala
authors: A
authors: Raju
authors: Popat
authors: P
authors: Baban Mohite
authors: Ramdas
authors: R
authors: Bhanudas Pandhare
keywords: Analgesic Activity; Isoxazole; Pyrazole; Pyrimidine; Tetrazole; Triazole