title: New derivatives of aryl-propionic acid. Synthesis and biological evaluation.
abstract: OBJECTIVE
  To design new derivatives of aryl-propionic acid with potential antibacterial and antioxidant activity.
  
  
  METHODS
  New hydrazone of ibuprofen (2-(4-isobutylphenyl)propionic acid) have been synthesized by reaction of ethyl ester of ibuprofen with hydrazine hydrate and then condensation of corresponding hydrazide with various aromatic aldehydes.
  
  
  RESULTS
  The synthesized compounds were screened for their antibacterial activity against Gram positive (Staphylococcus aureus ATCC 25923, Sarcinalutea ATCC 9341, Bacillus cereus ATCC 14579, Bacillus subtilis) and Gram negative bacterial strains (Escherichia coli ATCC 25922). Some of them were found to have good antibacterial activity. The antioxidant activity of these compounds was also tested using the total antiox idant capacity test.
  
  
  CONCLUSIONS
  The chemical modulations performed on ibuprofen structure have a good influence on the biological activity of the synthesized compounds.
authors: Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Ioana
authors: I
authors: Vasincu
authors: Maria
authors: M
authors: Apotrosoaei
authors: Cristina
authors: C
authors: Tuchiluş
authors: Andreea Teodora
authors: AT
authors: Pânzariu
authors: Oana
authors: O
authors: Dragostin
authors: D
authors: D
authors: Lupaşcu
authors: Lenuta
authors: L
authors: Profire
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis*; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000975:Antioxidants; D006834:Hydrazines; D006835:Hydrazones; D011422:Propionates; C586902:ibuprofen hydrazide; C029424:hydrazine; D007052:Ibuprofen