title: Milder multiple sclerosis course in patients with concomitant inflammatory bowel disease.
abstract: An association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested. The purpose of this study was to compare the disease course of patients with both MS and IBD with that of patients with isolated MS or isolated IBD. Sixty-six MS-IBD patients were identified and were matched with 251 isolated MS and 257 isolated IBD controls. Main outcomes were scores using the Expanded Disability Status Scale (EDSS) in MS and extent of disease extension in IBD at last clinical evaluation. After a median 12 years of disease duration, the median EDSS and the percentages of patients reaching an EDSS of 3.0 and 4.0 were significantly lower in MS-IBD patients than in controls. MS had no impact on IBD. MS course appears to be milder in patients with concomitant IBD.
authors: Department of Neurology, Hôpital Roger Salengro, France Department of Immunology, University of Lille Nord de France, France helene.zephir@chru-lille.fr.
authors: Hélène
authors: H
authors: Zéphir
authors: Epidemiology Unit, Lille Hospital, France.
authors: Corinne
authors: C
authors: Gower-Rousseau
authors: Department of Biostatistics and Institut National de la Santé et de la Recherche Médicale (INSERM), Lille University Hospital, France.
authors: Julia
authors: J
authors: Salleron
authors: Department of Neurology, Hôpital Roger Salengro, France.
authors: Olivier
authors: O
authors: Simon
authors: Department of Neurology, Hôpital Central, France.
authors: Marc
authors: M
authors: Debouverie
authors: Department of Neurology, CHU Centre hospitalier Universitaire Pontchaillou, France.
authors: Emmanuelle
authors: E
authors: Le Page
authors: Department of Gastroenterology, Beaujon Hospital, France.
authors: Yoram
authors: Y
authors: Bouhnik
authors: Department of Neurology, University Hospital, Nice, France.
authors: Christine
authors: C
authors: Lebrun-Frenay
authors: Department of Neurology, Salpêtrière Hospital, France.
authors: Caroline
authors: C
authors: Papeix
authors: Gastroenterology Unit, Hôpital Huriez, France.
authors: Benoît
authors: B
authors: Vigneron
authors: Saint-Louis Hospital, APHP Assistance Publique des hôpitaux de Paris, France.
authors: Matthieu
authors: M
authors: Allez
authors: Department of Immunology, University of Lille Nord de France, France.
authors: Lionel
authors: L
authors: Prin
authors: Gastroenterology and Nutrition Unit, St-Antoine Hospital, France.
authors: Jacques
authors: J
authors: Cosnes
authors: Department of Neurology, Hôpital Roger Salengro, France Department of Immunology, University of Lille Nord de France, France.
authors: Patrick
authors: P
authors: Vermersch
authors: Gastroenterology Unit, Hôpital Huriez, France Icahn School of Medicine at Mount Sinai, USA.
authors: Jean-Frédéric
authors: JF
authors: Colombel
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D011379:Prognosis; D065840:Protective Factors; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
keywords: Multiple sclerosis; colitis; epidemiology; prognosis