title: Population genetics of insertion-deletion polymorphisms in South Koreans using Investigator DIPplex kit.
abstract: We assessed the applicability of 30 insertion-deletion polymorphisms (INDELs) in forensic use and the level of genetic diversity in South Korea (n=373) using the Investigator DIPplex kit (Qiagen). Allele frequencies, heterozygocities, and forensic efficacy parameters were determined. No deviation from Hardy-Weinberg equilibrium was observed for any of the INDEL markers. A high level of discrimination power was observed (combined power of discrimination: 0.99999999995). The combined match probability value was 2.84 × 10(-11) and the mean typical paternity indices were 0.878. Furthermore, we found one microvariant allele at HLD93 (rs2307570) that has not been reported. We expect that these 30 loci of INDEL markers will be useful for forensic identification and paternity testing in the South Korean population.
authors: Forensic DNA Center, National Forensic Service, Seoul 158-707, Republic of Korea; Department of Biological Science, Kongju National University, 182 Gongju, Chungnam 314-701, Republic of Korea.
authors: Ki Min
authors: KM
authors: Seong
authors: Ji Hye
authors: JH
authors: Park
authors: Young Se
authors: YS
authors: Hyun
authors: Pil Won
authors: PW
authors: Kang
authors: Dong Ho
authors: DH
authors: Choi
authors: Myun Soo
authors: MS
authors: Han
authors: Ki Won
authors: KW
authors: Park
authors: Ki Wha
authors: KW
authors: Chung
mesh_terms: D001483:Base Sequence; D017931:DNA Primers; D005828:Genetics, Population; D006801:Humans; D011110:Polymorphism, Genetic; D056910:Republic of Korea
chemical_list: D017931:DNA Primers
keywords: Biallelic; INDEL; Insertion–deletion polymorphisms; Investigator DIPplex(®) kit; South Korean