title: Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.
abstract: Six molecules were obtained by the combination of three biologically and medicinally significant moieties-indole, chrysin and pyrazole. Bio-evaluation of these hybrid molecules showed significant inhibition of COX-2 enzymatic activity over that of COX-1 and appreciable anti-nociceptive activity, checked at swiss albino mice.
authors: Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: palwinder_singh_2000@yahoo.com.
authors: Palwinder
authors: P
authors: Singh
authors: Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
authors: Shaveta
authors: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
authors: Surbhi
authors: S
authors: Sharma
authors: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
authors: Rajbir
authors: R
authors: Bhatti
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005260:Female; D008297:Male; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D051546:Cyclooxygenase 2
keywords: Anti-inflammatory; Anti-nociceptive; Chrysin; Indole; Molecular modeling