title: A special population of regulatory T cells potentiates muscle repair.
abstract: Long recognized to be potent suppressors of immune responses, Foxp3(+)CD4(+) regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological processes. We describe a phenotypically and functionally distinct population of Treg cells that rapidly accumulated in the acutely injured skeletal muscle of mice, just as invading myeloid-lineage cells switched from a proinflammatory to a proregenerative state. A Treg population of similar phenotype accumulated in muscles of genetically dystrophic mice. Punctual depletion of Treg cells during the repair process prolonged the proinflammatory infiltrate and impaired muscle repair, while treatments that increased or decreased Treg activities diminished or enhanced (respectively) muscle damage in a dystrophy model. Muscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite cells in vitro and improved muscle repair in vivo. Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies.
authors: Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
authors: Dalia
authors: D
authors: Burzyn
authors: Wilson
authors: W
authors: Kuswanto
authors: Dmitriy
authors: D
authors: Kolodin
authors: Jennifer L
authors: JL
authors: Shadrach
authors: Massimiliano
authors: M
authors: Cerletti
authors: Young
authors: Y
authors: Jang
authors: Esen
authors: E
authors: Sefik
authors: Tze Guan
authors: TG
authors: Tan
authors: Amy J
authors: AJ
authors: Wagers
authors: Christophe
authors: C
authors: Benoist
authors: Diane
authors: D
authors: Mathis
mesh_terms: D066258:Amphiregulin; D000818:Animals; D066255:EGF Family of Proteins; D006023:Glycoproteins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008221:Lymphoid Tissue / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000166:cytology* / Q000276:immunology / Q000293:injuries / Q000502:physiology*; D009136:Muscular Dystrophies / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D012038:Regeneration; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D059467:Transcriptome
chemical_list: D066258:Amphiregulin; C587849:Areg protein, mouse; D066255:EGF Family of Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D011948:Receptors, Antigen, T-Cell