title: Interactions between drugs and polymers influencing hot melt extrusion.
abstract: OBJECTIVE
  Hot melt extrusion (HME) as a technique for producing amorphous solid dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge for the application of HME is the thermal degradation of drug, poor physical stability of ASD and precipitation of drug during dissolution. Interactions between drugs and polymers may play an important role in overcoming these barriers. In this review, influence of drug-polymer interactions on HME and the methods for characterizing the drug-polymer interactions were reviewed.
  
  
  RESULTS
  Strong drug-polymer interactions, especially ionic interactions and hydrogen bonds, are helpful to improving the thermal stability of drug during HME, enhancing the physical stability of ASD during storage and maintaining supersaturated solution after dissolution in gastrointestinal tract. The interactions can be quantitatively and qualitatively characterized by many analysing methods.
  
  
  CONCLUSIONS
  As many factors collectively determine the properties of HME products, drug-polymer interactions play an extremely important role. However, the action mechanisms of drug-polymer interactions need intensive investigation to provide more useful information for optimizing the formulation and the process parameters of HME.
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors: Yongcheng
authors: Y
authors: Li
authors: Huishi
authors: H
authors: Pang
authors: Zhefei
authors: Z
authors: Guo
authors: Ling
authors: L
authors: Lin
authors: Yixuan
authors: Y
authors: Dong
authors: Ge
authors: G
authors: Li
authors: Ming
authors: M
authors: Lu
authors: Chuangbin
authors: C
authors: Wu
mesh_terms: D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005615:Freezing; D006358:Hot Temperature; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers; D012996:Solutions
keywords: amorphous solid dispersion; dissolution; hot melt extrusion; interaction; physical stability