title: 8-hydroxydeoxyguanosine as a useful marker for determining the severity of trichloroethylene exposure.
abstract: The aim of this study was to determine 8-hydroxydeoxyguanosine (8-OH-dG) levels in trichloroethylene (TCE)-exposed workers. Oxidative stress biomarkers and biochemical parameters were monitored among 26 TCE-exposed workers and 78 age-matched control subjects. Levels of urinary 8-OH-dG were analyzed by liquid chromatography tandem mass spectrometry. Urinary 8-OH-dG levels were significantly higher for TCE-exposed group (p < .001). Spearman's correlation test revealed positive correlations between urinary trichloroacetic acid levels and age, urinary 8-OH-dG, urinary total oxidant status, and urinary total antioxidant status (p = .042, p < .001, p < .001, and p < .001, respectively). 8-OH-dG may be a useful marker to determine the extent of TCE exposure.
authors: a Department of Biochemistry , ANKALAB Laboratory , Ankara , Turkey.
authors: Sedat
authors: S
authors: Abusoglu
authors: Huseyin Tugrul
authors: HT
authors: Celik
authors: Engin
authors: E
authors: Tutkun
authors: Hinç
authors: H
authors: Yilmaz
authors: Muhittin A
authors: MA
authors: Serdar
authors: Ceylan Demir
authors: CD
authors: Bal
authors: M
authors: M
authors: Yildirimkaya
authors: M
authors: M
authors: Avcikucuk
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D006403:Hematologic Tests; D006801:Humans; D007854:Lead / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D018384:Oxidative Stress / Q000187:drug effects; D014241:Trichloroethylene / Q000494:pharmacology*; D014421:Turkey
chemical_list: D015415:Biomarkers; D014241:Trichloroethylene; D007854:Lead; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine