title: Translational research using a mouse model of intracranial aneurysm.
abstract: We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in this model show an infiltration with inflammatory cells. This mouse model can be used to study the mechanisms and the potential preventive treatments for aneurysmal rupture.
authors: Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, No. 3C-38, San Francisco, CA, 94110, USA.
authors: Kosuke
authors: K
authors: Wada
authors: Hiroshi
authors: H
authors: Makino
authors: Kenji
authors: K
authors: Shimada
authors: Fumiaki
authors: F
authors: Shikata
authors: Atsushi
authors: A
authors: Kuwabara
authors: Tomoki
authors: T
authors: Hashimoto
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000473:pathology*; D051379:Mice; D012422:Rupture, Spontaneous / Q000473:pathology; D057170:Translational Research, Biomedical