title: Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia.
abstract: Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.
authors: Neuroscience Research Australia, Sydney, NSW, Australia.
authors: Emma C
authors: EC
authors: Flanagan
authors: Neuroscience Research Australia, Sydney, NSW, Australia School of Medical Sciences, University of New South Wales, NSW, Australia Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia.
authors: Sicong
authors: S
authors: Tu
authors: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
authors: Samrah
authors: S
authors: Ahmed
authors: Neuroscience Research Australia, Sydney, NSW, Australia School of Medical Sciences, University of New South Wales, NSW, Australia Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia.
authors: John R
authors: JR
authors: Hodges
authors: Neuroscience Research Australia, Sydney, NSW, Australia School of Medical Sciences, University of New South Wales, NSW, Australia Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors: Michael
authors: M
authors: Hornberger
mesh_terms: D000275:Adjustment Disorders / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D018888:Aphasia, Primary Progressive / Q000145:classification / Q000150:complications*; D005260:Female; D006801:Humans; D007807:Language Tests; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology*
keywords: Memory; PPA; PiB; lv-PPA; na-PPA; orientation