title: Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research.
abstract: OBJECTIVE
  To underscore recent clinical studies, which evaluate the association between dietary protein and bone health.
  
  
  RESULTS
  Epidemiologic studies show greater protein intake to be beneficial to bone health in adults. In addition, randomized controlled trials show that protein's positive effect on bone health is augmented by increased calcium intake. The relation between dietary protein and fracture risk is unclear. Dietary protein may positively impact bone health by increasing muscle mass, increasing calcium absorption, suppressing parathyroid hormone, and augmenting insulin-like growth factor 1 production; but the effects of other factors that contribute to this association, such as dietary protein dose and timing response, require further research.
  
  
  CONCLUSIONS
  The positive effects of protein intake on bone health may only be beneficial under conditions of adequate calcium intake. Dietary protein's relation with fracture risk requires further investigation.
authors: aThe Institute for Aging Research, Hebrew SeniorLife, Boston Massachusetts bDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts cDepartment of Allied Health Sciences, The University of Connecticut, Storrs, Connecticut, USA.
authors: Kelsey M
authors: KM
authors: Mangano
authors: Shivani
authors: S
authors: Sahni
authors: Jane E
authors: JE
authors: Kerstetter
mesh_terms: D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015201:Meta-Analysis as Topic; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D010281:Parathyroid Hormone; D007334:Insulin-Like Growth Factor I