title: Higher risk for meningioma in women with uterine myoma: a nationwide population-based retrospective cohort study.
abstract: OBJECTIVE
  Evidence suggests that hormones play a role in modifying both uterine myoma (UM) and meningioma. A number of studies have observed the positive association between these diseases. The aim of the current population-based study was to determine if women with UM are at a higher risk for meningioma.
  
  
  METHODS
  The authors used data from the National Health Insurance system of Taiwan for the study. The UM cohort contained 281,244 women. Each woman was randomly frequency-matched with 4 women without UM, based on age, index year of diagnosis, occupation, urbanization (urbanization level was categorized by the population density of the residential area into 4 levels, with Level 1 as the most urbanized and Level 4 as the least urbanized), and comorbidity, to form the control cohort. Cox's proportional hazard regression analysis was conducted to estimate the influence of UM on the meningioma risk.
  
  
  RESULTS
  Among women with UM, the risk of developing meningioma was significantly higher (45%) than among women without UM (95% CI 1.23-1.70). The same phenomenon was observed among most age groups, but a significant difference was only seen in the middle-age range. For women with UM, further analysis did not show a significant change after myomectomy. The cumulative incidence of meningioma between groups with and without UM differed over time.
  
  
  CONCLUSIONS
  The nationwide population-based cohort study found that Taiwanese women with UM are at higher risk for developing meningioma.
authors: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei;
authors: Yu-Shu
authors: YS
authors: Yen
authors: Li-Min
authors: LM
authors: Sun
authors: Cheng-Li
authors: CL
authors: Lin
authors: Shih-Ni
authors: SN
authors: Chang
authors: Fung-Chang
authors: FC
authors: Sung
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007889:Leiomyoma / Q000453:epidemiology* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000453:epidemiology*; D008579:Meningioma / Q000453:epidemiology*; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D063186:Uterine Myomectomy / Q000706:statistics & numerical data; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000601:surgery