title: [Risk factors associated with cardiac involvement in patients with dermatomyositis/polymyositis].
abstract: OBJECTIVE
  To identify risk factors associated with cardiac involvement (CI) in patients with dermatomyositis/polymyositis (DM/PM).
  
  
  METHODS
  Medical records of 129 DM/PM patients were reviewed retrospectively. The risk factors associated with CI in those patients were screened through Xt tests or independent tests before a multivariate logistic regression analysis was performed. ROC curves were constructed to determine diagnostic values of the identified risk factors.
  
  
  RESULTS
  CI occurred in 59 (45. 74%) of DM/PM patients, with 41 (69. 49%) showing electrocardiographic (ECG) abnormality; 25 (42. 37%) showing ultrasonic cardiogram (UCG) abnormality; 8 (13. 56%) being diagnosed with heart failure, and 2 (3. 39%) being diagnosed with myocardial infarction. Eight (13.56%) of the patients with CI died. CI was more likely to occur in patients with an older age, having interstitial lung disease, antinuclear antibody (ANA) positive, and anti-Jo-1 antibody positive (P<0.05). The logistic regression analysis revealed that interstitial lung disease (beta=1. 554), aspartic aminotransferase/creatine kinases (AST/CK) ratio (beta=1.189), positive ANA (beta= 1. 172) and age (beta=0.042) were risk factors associated with CI (P<0. 05). Notable areas under ROC curve (0. 642) was found for AST/CK in determining CI in DM/PM patients (P<0. 05), albeit with low accuracy. A cut-off of AST/CK ratio at 0. 312 was identified as a reference point for determining CI in patients with DM/PM.
  
  
  CONCLUSIONS
  Cardiac involvement is the most common complication of DM/PM, although the majority are subclinical. ECG and UCG are common tools for diagnosing cardiac involvement. Interstitial lung disease, AST/CK ratio, positive ANA and age are predictors of CI in DM/PM patients.
authors: Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Chuan
authors: C
authors: Zuo
authors: Xuan-Di
authors: XD
authors: Wei
authors: Ya-Li
authors: YL
authors: Ye
authors: Yan
authors: Y
authors: Liang
authors: Geng
authors: G
authors: Yin
authors: Min
authors: M
authors: Yang
authors: Qi-Bing
authors: QB
authors: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003882:Dermatomyositis / Q000150:complications*; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017285:Polymyositis / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult