title: [Polymorphism of helicobacter pylori and the presence of genes babA2 and sabA and endoscopic and histopathological changes in patients infected with Heicobacter pylori].
abstract: The infection of Helicobacter pylori is the main reason of a duodenal and gastric ulcer disease. Among other virulence factors of Helicobacter pylori, there are outer membrane proteins (OMPs), such as babA2 and sabA.
  
  
  OBJECTIVE
  An assessment of a relationship between the presence of genes babA2 and sabA and endoscopic and histopathologic changes during gastritis, duodenitis and an ulcer disease.
  
  
  METHODS
  We included 119 patients aged from 3 to 17 (average 13.6) with gastritis and duodenitis and the infection of Helicobacter pylori. The endoscopy was conducted with taking samples of the mucosa for the histopathologic and genetic examination. The degree of endoscopic and histopatologic changes were determined according to Sydney's classification. The patients were devided in the extra groups with a small level (without erosion) and with a large level (with erosion) of endoscopic changes. To identify the infection of Helicobacter pylori, the PCR technique was used and then the presence of the babA2 and sabA genes of Helicobacter pylori was verified. The genetic confirmation of Helicobacter pylori infection was obtained in 88 patients and material was directed to the further examination.
  
  
  RESULTS
  Not statistically significant differences were determined between endoscopic and histopathologic pictures and either the presence or absence of the genes babA2 and sabA.
  
  
  CONCLUSIONS
  The presence of the genes babA2 and sabA is not related with level of endoscopic and histopathologic changes in pediatrics patients.
authors: Collegium Medicum in Bydgoszcz, the Nicolaus Copemrnicus University of Torun, Department of Pediatrics, Allergology and Gastroenterology. klped@cm.umk.pl
authors: Joanna
authors: J
authors: Gasiorowska
authors: Collegium Medicum in Bydgoszcz, the Nicolaus Copemrnicus University of Torun, Department of Endoscopy and Gastrointestinal Functional Testing for Children and Adolescents.
authors: Monika
authors: M
authors: Parzecka
authors: Collegium Medicum in Bydgoszcz, the Nicolaus Copemrnicus University of Torun, Department of Endoscopy and Gastrointestinal Functional Testing for Children and Adolescents.
authors: Anna
authors: A
authors: Szaflarska-Poplawska
authors: Collegium Medicum in Bydgoszcz, the Nicolaus Copemrnicus University of Torun, Department of Molecular Genetics and Justice.
authors: Marta
authors: M
authors: Gorzkiewicz
authors: Collegium Medicum in Bydgoszcz, the Nicolaus Copemrnicus University of Torun, Department of Molecular Genetics and Justice.
authors: Tomasz
authors: T
authors: Grzybowski
mesh_terms: D018829:Adhesins, Bacterial / Q000302:isolation & purification*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004382:Duodenitis / Q000382:microbiology / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology*; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D013276:Stomach Ulcer / Q000382:microbiology / Q000473:pathology; D037521:Virulence Factors / Q000235:genetics
chemical_list: D018829:Adhesins, Bacterial; C400429:BabA protein, Helicobacter pylori; C500808:SabA protein, Helicobacter pylori; D037521:Virulence Factors