title: Bioreducible nanocapsules prepared from the self-assembly of branched polymer in nanodroplet.
abstract: Though great attention has been paid in constructing well-defined nano-structures via the self-assembly of amphiphilic macromolecules, the self-assembly of non-amphiphilic macromolecules in nanodroplet has drawn less attention up to now. Recently, we prepared a temperature-responsive PEG-based branched polymer with disulfide bonds in its backbone via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(2-methoxyethoxy) ethyl methacrylate, oligo(ethylene glycol) methacrylate, and N,N'-cystamine bisacrylamide. Subsequently, we loaded the branched polymer into nanodroplets, and have found that the self-assembly behaviors of this branched poly-mer in the nanodroplet are different from those in common solution. Bioreducible nanocapsules with tunable size can easily formed in nanodroplet even at high concentration.
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230036, Anhui, P. R. China.
authors: Long-Hai
authors: LH
authors: Wang
authors: Sheng-Gang
authors: SG
authors: Ding
authors: Jun-Jie
authors: JJ
authors: Yan
authors: Ye-Zi
authors: YZ
authors: You
mesh_terms: D008689:Methacrylates / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D008689:Methacrylates; D053769:Nanocapsules; D011108:Polymers; D011092:Polyethylene Glycols
keywords: branched polymer; nanocapsules; nanodroplets; self-assembly; self-cross-linking