title: Splenic hamartoma: A case report and review of the literature.
abstract: Splenic hamartoma is a rare benign malformation, composed of an anomalous mixture of normal splenic elements, often found incidentally while working up other complaints or at autopsy. A splenic mass was incidentally found while evaluating the effects of a traffic accident in a 63-year-old woman. Abdominal computed tomography revealed a well-defined splenic mass with rim enhancement. The patient underwent splenectomy. The resected spleen contained a well-defined mass lesion measuring 3.5 cm × 3.0 cm. Microscopic examination revealed disorganized slit-like vascular channels lined by plump endothelial cells without atypia. The cells lining the vascular channels were positive for CD8, CD31, CD34 and vimentin. Endothelial cells that are positive for CD8 are a key feature that differentiates hamartoma from other vascular lesions of the spleen. Although this tumor is very rare, it must be included in the differential diagnosis of splenic mass-forming lesions.
authors: Jongmin Sim, Hye In Ahn, Hulin Han, Young Jin Jun, Abdul Rehman, Se Min Jang, Kiseok Jang, Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Sungdong-ku, Seoul 133-792, South Korea.
authors: Jongmin
authors: J
authors: Sim
authors: Hye In
authors: HI
authors: Ahn
authors: Hulin
authors: H
authors: Han
authors: Young Jin
authors: YJ
authors: Jun
authors: Abdul
authors: A
authors: Rehman
authors: Se Min
authors: SM
authors: Jang
authors: Kiseok
authors: K
authors: Jang
authors: Seung Sam
authors: SS
authors: Paik
keywords: Hamartoma; Malformation; Spleen; Splenoma