title: New titanocene derivatives with high antiproliferative activity against breast cancer cells.
abstract: The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.
authors: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy.
authors: Carmela
authors: C
authors: Saturnino
authors: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy.
authors: Esther
authors: E
authors: Sirignano
authors: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy.
authors: Antonio
authors: A
authors: Botta
authors: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy. Electronic address: s.sinicropi@unical.it.
authors: Maria Stefania
authors: MS
authors: Sinicropi
authors: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
authors: Anna
authors: A
authors: Caruso
authors: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
authors: Assunta
authors: A
authors: Pisano
authors: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
authors: Rosamaria
authors: R
authors: Lappano
authors: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
authors: Marcello
authors: M
authors: Maggiolini
authors: Department of Chemistry and Biology, University of Salerno, Italy.
authors: Pasquale
authors: P
authors: Longo
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C406884:titanocene
keywords: Breast cancer cells; Metal-based anticancer drugs; Titanocene compounds