title: Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.
abstract: For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.
authors: Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Christopher R
authors: CR
authors: Bohl
authors: Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Sitaram
authors: S
authors: Harihar
authors: Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Warren L
authors: WL
authors: Denning
authors: Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Rahul
authors: R
authors: Sharma
authors: Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Danny R
authors: DR
authors: Welch
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins