title: Diabetes, dysglycemia and cognitive dysfunction.
abstract: Evidence from the last decade supports the hypothesis that diabetes may be viewed as a disease of accelerated cognitive ageing. It is a risk factor for the development of dementia, for an accelerated rate of cognitive decline and for cognitive dysfunction. Thus, 'diabetes-related cognitive dysfunction' may be viewed as another long-term complication of diabetes. This article will review the evidence supporting this hypothesis and will elaborate on the implications for patient care, as well as discuss potential treatment options and their limitation. The final section reviews possible mechanistic explanations.
authors: Tali
authors: T
authors: Cukierman-Yaffe
mesh_terms: D000368:Aged; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003704:Dementia / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007003:Hypoglycemia / Q000175:diagnosis / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011972:Receptor, Insulin / Q000502:physiology; D012307:Risk Factors; D012648:Self Care
chemical_list: D006442:Glycated Hemoglobin; D011972:Receptor, Insulin; C517652:hemoglobin A1c protein, human
keywords: Dysglycemia; cognitive dysfunction; diabetes