title: Clinical significance of serum triple monoclonal components: a report of 6 cases and a review of the literature.
abstract: A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.
authors: Division of Hematology, Second University of Naples, Naples, Italy.
authors: Salvatore
authors: S
authors: Guastafierro
authors: Division of Hematology, Second University of Naples, Naples, Italy.
authors: Antonello
authors: A
authors: Sica
authors: Division of Hematology, Second University of Naples, Naples, Italy.
authors: Rita Rosaria
authors: RR
authors: Parascandola
authors: Division of Hematology, Second University of Naples, Naples, Italy.
authors: Maria Giovanna
authors: MG
authors: Ferrara
authors: Division of Hematology, Second University of Naples, Naples, Italy.
authors: Anna
authors: A
authors: Di Martino
authors: Department of General Pathology, Second University of Naples, Naples, Italy.
authors: Luciano
authors: L
authors: Pezone
authors: Division of Hematology, Second University of Naples, Naples, Italy. Electronic address: umberto.falcone@unina2.it.
authors: Umberto
authors: U
authors: Falcone
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000097:blood*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000175:diagnosis; D008297:Male; D011087:Polycythemia Vera / Q000097:blood / Q000175:diagnosis; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000175:diagnosis
chemical_list: D000911:Antibodies, Monoclonal
keywords: Cancer; Diagnosis; Immunofixation; Intracellular immunofluorescence; Lymphoproliferative disorders; Serum electrophoresis; Triple monoclonal component