title: Nitric oxide-matrix metaloproteinase-9 interactions: biological and pharmacological significance--NO and MMP-9 interactions.
abstract: Nitric oxide (NO) and matrix metalloproteinase 9 (MMP-9) levels are found to increase in inflammation states and in cancer, and their levels may be reciprocally modulated. Understanding interactions between NO and MMP-9 is of biological and pharmacological relevance and may prove crucial in designing new therapeutics. The reciprocal interaction between NO and MMP-9 have been studied for nearly twenty years but to our knowledge, are yet to be the subject of a review. This review provides a summary of published data regarding the complex and sometimes contradictory effects of NO on MMP-9. We also analyse molecular mechanisms modulating and mediating NO-MMP-9 interactions. Finally, a potential therapeutic relevance of these interactions is presented.
authors: Shane
authors: S
authors: O'Sullivan
authors: Carlos
authors: C
authors: Medina
authors: Mark
authors: M
authors: Ledwidge
authors: Marek W
authors: MW
authors: Radomski
authors: John F
authors: JF
authors: Gilmer
mesh_terms: D000818:Animals; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D020780:Matrix Metalloproteinase 9