title: Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-γ autoantibody.
abstract: An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, he was successfully treated with rituximab to eliminate B cells and thereby the autoantibody. Subsequently, he obtained a sustained remission from infection.
authors: Division of Mycobacterial and Respiratory Infections.
authors: Christopher A
authors: CA
authors: Czaja
authors: Patricia A
authors: PA
authors: Merkel
authors: Edward D
authors: ED
authors: Chan
authors: Laurel L
authors: LL
authors: Lenz
authors: Molly L
authors: ML
authors: Wolf
authors: Rafeul
authors: R
authors: Alam
authors: Stephen K
authors: SK
authors: Frankel
authors: Aryeh
authors: A
authors: Fischer
authors: Shaila
authors: S
authors: Gogate
authors: Carlos M
authors: CM
authors: Perez-Velez
authors: Vijaya
authors: V
authors: Knight
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy* / Q000276:immunology*; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D007155:Immunologic Factors; D000069283:Rituximab; D007371:Interferon-gamma
keywords: immune deficiency; interferon gamma; nontuberculous mycobacteria; rituximab