title: The influence of Shc proteins on life span in mice.
abstract: The signaling molecule p66Shc is often described as a longevity protein. This conclusion is based on a single life span study that used a small number of mice. The purpose of the present studies was to measure life span in a sufficient number of mice to determine if longevity is altered in mice with decreased Shc levels (ShcKO). Studies were completed at UC Davis and the European Institute of Oncology (EIO). At UC Davis, male C57BL/6J WT and ShcKO mice were fed 5% or 40% calorie-restricted (CR) diets. In the 5% CR group, there was no difference in survival curves between genotypes. There was also no difference between genotypes in prevalence of neoplasms or other measures of end-of-life pathology. At 40% calorie restriction group, 70th percentile survival was increased in ShcKO, while there were no differences between genotypes in median or subsequent life span measures. At EIO, there was no increase in life span in ShcKO male or female mice on C57BL/6J, 129Sv, or hybrid C57BL/6J-129Sv backgrounds. These studies indicate that p66Shc is not a longevity protein. However, additional studies are needed to determine the extent to which Shc proteins may influence the onset and severity of specific age-related diseases.
authors: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis. jjramsey@ucdavis.edu.
authors: Jon J
authors: JJ
authors: Ramsey
authors: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis.
authors: Dianna
authors: D
authors: Tran
authors: Deparment of Experimental Oncology, European Institute of Oncology, Milan, Italy.
authors: Marco
authors: M
authors: Giorgio
authors: Comparative Pathology Laboratory, School of Veterinary Medicine.
authors: Stephen M
authors: SM
authors: Griffey
authors: Comparative Pathology Laboratory, School of Veterinary Medicine.
authors: Amanda
authors: A
authors: Koehne
authors: Comparative Pathology Laboratory, School of Veterinary Medicine.
authors: Steven T
authors: ST
authors: Laing
authors: Department of Public Health Sciences.
authors: Sandra L
authors: SL
authors: Taylor
authors: Department of Public Health Sciences.
authors: Kyoungmi
authors: K
authors: Kim
authors: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis.
authors: Gino A
authors: GA
authors: Cortopassi
authors: Department of Surgery, School of Medicine, and.
authors: K C Kent
authors: KC
authors: Lloyd
authors: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis.
authors: Kevork
authors: K
authors: Hagopian
authors: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis.
authors: Alexey A
authors: AA
authors: Tomilov
authors: Deparment of Experimental Oncology, European Institute of Oncology, Milan, Italy.
authors: Enrica
authors: E
authors: Migliaccio
authors: Deparment of Experimental Oncology, European Institute of Oncology, Milan, Italy.
authors: Pier Giuseppe
authors: PG
authors: Pelicci
authors: Department of Nutrition, University of California, Davis.
authors: Roger B
authors: RB
authors: McDonald
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D031204:Caloric Restriction; D005260:Female; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055765:Shc Signaling Adaptor Proteins / Q000502:physiology*; D013045:Species Specificity; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
chemical_list: D055765:Shc Signaling Adaptor Proteins; C528034:Shc1 protein, mouse; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
keywords: Aging; Longevity; Pathology.; Shc