title: Cellular senescence in the Penna model of aging.
abstract: Cellular senescence is thought to play a major role in age-related diseases, which cause nearly 67% of all human deaths worldwide. Recent research in mice showed that exercising mice had higher levels of telomerase, an enzyme that helps maintain telomere length, than nonexercising mice. A commonly used model for biological aging was proposed by Penna. I propose a modification of the Penna model that incorporates cellular senescence and find an analytical steady-state solution following Coe, Mao, and Cates [Phys. Rev. Lett. 89, 288103 (2002)]. I find that models corresponding to delayed cellular senescence have younger populations that live longer. I fit the model to the United Kingdom's death distribution, which the original Penna model cannot do.
authors: Montgomery Blair High School, 51 University Boulevard East, Silver Spring, Maryland 20901, USA.
authors: Avikar
authors: A
authors: Periwal
mesh_terms: D000375:Aging / Q000235:genetics; D016922:Cellular Senescence; D006801:Humans; D008954:Models, Biological; D009154:Mutation