title: Galectin-3: its role in asthma and potential as an anti-inflammatory target.
abstract: Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression are commonly seen in cancer and pre-cancerous conditions, and Gal-3 may be involved in the regulation of diverse cancer cell activities that contribute to tumourigenesis, cancer progression and metastasis. In addition, Gal-3 is a pro-inflammatory regulator in rheumatoid arthritis. Gal-3 has been shown to be involved in many aspects in allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype as well as increased expression of inflammatory mediators. In an in vivo model it was shown that bronchoalveolar lavage (BAL) fluid from ovalbumin-challenged mice contained significantly higher levels of Gal-3 compared to control mice. The molecular mechanisms of Gal-3 in human asthma have not been fully elucidated. This review will focus on what is known about the Gal-3 and its role in the pathophysiological mechanisms of asthma to evaluate the potential of Gal-3 as a biomarker and therapeutic target of asthma.
authors: Peng
authors: P
authors: Gao
authors: Jodie L
authors: JL
authors: Simpson
authors: Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle NSW2305, Australia. doctorzhangj@sina.com.
authors: Jie
authors: J
authors: Zhang
authors: Peter G
authors: PG
authors: Gibson
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D015415:Biomarkers; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D037502:Galectin 3 / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D010047:Ovalbumin / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D037502:Galectin 3; D010047:Ovalbumin