title: Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review.
abstract: Mitochondrial dysfunction has been linked to many diseases including metabolic diseases such as diabetes. Peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) is a superfamily of transcriptional co-activators which are important precursors to mitochondrial biosynthesis found in most cells including skeletal muscle. The PGC-1 superfamily consists of three variants all of which are directly involved in controlling metabolic gene expression including those regulating fatty acid oxidation and mitochondrial proteins. In contrast to previous reviews on PGC-1, this mini-review summarizes the current knowledge of many known dietary stimulators of PGC-1 and the subsequent mitochondrial biosynthesis with associated metabolic benefit in skeletal muscle.
authors: Department of Health, Exercise and Sports Science, University of New Mexico, 1 University Blvd, Albuquerque, NM, 87131, USA, vaughanr@unm.edu.
authors: Roger A
authors: RA
authors: Vaughan
authors: Christine M
authors: CM
authors: Mermier
authors: Marco
authors: M
authors: Bisoffi
authors: Kristina A
authors: KA
authors: Trujillo
authors: Carole A
authors: CA
authors: Conn
mesh_terms: D000818:Animals; D004032:Diet; D053263:Gene Regulatory Networks; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000502:physiology; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D063269:Mitochondrial Turnover; D018482:Muscle, Skeletal / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation
chemical_list: D024101:Mitochondrial Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors