title: Toward transduodenal diffuse optical tomography of proximal pancreas.
abstract: We demonstrate the feasibility of diffuse optical tomography (DOT) of the proximal pancreas by using optical applicator channels deployed longitudinally along the exterior surface of a duodenoscope. As the duodenum that nearly encircles the proximal pancreas forms a natural "C-loop" that is approximately three-quarters of a circle of 5-6 cm in diameter, a multichannel optical applicator attached to a duodenoscope has the potential to perform transduodenal DOT sampling of the bulk proximal pancreas wherein most cancers and many cystic lesions occur. The feasibility of transduodenal DOT is demonstrated on normal porcine pancreas tissues containing an introduced gelatinous inclusion of approximately 3 cm in diameter, by using nine source channels and six detector channels attached to a duodenoscope. Concurrent ultrasonography of the gelatinous inclusion in the porcine pancreas parenchyma provided a coarse, albeit indispensable, anatomic prior to transduodenal DOT in reconstructing a contrast of optical properties in the pancreas.
authors: Daqing
authors: D
authors: Piao
authors: Kenneth E
authors: KE
authors: Bartels
authors: Russell G
authors: RG
authors: Postier
authors: G Reed
authors: GR
authors: Holyoak
authors: Jerry W
authors: JW
authors: Ritchey
mesh_terms: D000818:Animals; D004386:Duodenum; D010179:Pancreas; D010182:Pancreatic Diseases / Q000175:diagnosis; D013552:Swine; D041622:Tomography, Optical / Q000379:methods*