title: Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography.
abstract: Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive coronary stenosis, and the magnitude of left ventricular (LV) hypertrophy. The patients' mean coronary artery calcium score was 198.8 ± 312.0 and was positively correlated with the number of coronary risk factors (r = 0.32; P < 0.05). Of the 51 patients with HCM, 42 (82.4 %) had some degree of stenosis and 8 (15.7 %) had obstructive stenosis. Noncalcified and mixed plaques were detected in 14 (27.5 %) and 11 (21.6 %) patients, respectively. Multivariate logistic regression revealed that diabetes was an independent indicator of the presence of obstructive stenosis in HCM patients. Multivariate linear regression revealed that low estimated glomerular filtration rates and high triglyceride concentrations were independent indicators of higher LV mass indexes. In conclusion, cardiac CT revealed that coronary artery disease was common among patients with HCM. The presence of obstructive coronary stenosis and the magnitude of LV hypertrophy were related to the presence of diabetes, triglyceride levels, and estimated glomerular filtration rate.
authors: First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan, satosi01@naramed-u.ac.jp.
authors: Satoshi
authors: S
authors: Okayama
authors: Tsunenari
authors: T
authors: Soeda
authors: Rika
authors: R
authors: Kawakami
authors: Yasuhiro
authors: Y
authors: Takami
authors: Satoshi
authors: S
authors: Somekawa
authors: Tomoya
authors: T
authors: Ueda
authors: Yu
authors: Y
authors: Sugawara
authors: Takaki
authors: T
authors: Matsumoto
authors: Ji Hee
authors: JH
authors: Sung
authors: Taku
authors: T
authors: Nishida
authors: Shiro
authors: S
authors: Uemura
authors: Yoshihiko
authors: Y
authors: Saito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D002637:Chest Pain; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D006334:Heart Function Tests; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009206:Myocardium / Q000473:pathology*; D015995:Prevalence; D012307:Risk Factors; D014057:Tomography, X-Ray Computed