title: The spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck.
abstract: OBJECTIVE
  To retrospectively investigate the clinicopathologic spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders (PTCLDs) of the head and neck.
  
  
  METHODS
  Archives of PTCLDs primarily arising in head and neck mucosa were reviewed. Immunostaining of CD20, CD3, CD4, CD8, CD30, CD56, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA), cytotoxic molecules (TIA-1, granzyme B, or perforin), and Ki67; in situ hybridization for Epstein-Barr virus; and T-cell receptor gene rearrangement analysis were performed.
  
  
  RESULTS
  Fourteen cases of primary mucosal anaplastic large cell lymphoma (M-ALCL) were identified, and no lymphomatoid papulosis (LyP) cases were found. All cases demonstrated atypical mononuclear neoplastic cells with diverse histology and cytomorphology. The typical immunophenotype of neoplastic cells was CD3-positive, CD4-positive, CD8-negative, CD30-positive, ALK-negative, and cytotoxic molecules-positive. Infiltration of inflammatory cells was common. All cases presented an indolent course, regardless of therapy.
  
  
  CONCLUSIONS
  PTCLDs of the head and neck provisionally included M-ALCL alone.
authors: Graduate student, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Graduate student, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: WeiGe
authors: W
authors: Wang
authors: Graduate student, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Graduate student, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Ying
authors: Y
authors: Cai
authors: Associate Professor, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Associate Professor, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: WeiQi
authors: W
authors: Sheng
authors: Associate Professor, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Associate Professor, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: HongFen
authors: H
authors: Lu
authors: Associate Professor, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Associate Professor, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: leexiaoqiu@hotmail.com.
authors: XiaoQiu
authors: X
authors: Li
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics; D005260:Female; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000276:immunology* / Q000473:pathology / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D017730:Ki-1 Antigen