title: Small-animal research imaging devices.
abstract: The scientific study of living animals may be dated to Aristotle's original dissections, but modern animal studies are perhaps a century in the making, and advanced animal imaging has emerged only during the past few decades. In vivo imaging now occupies a growing role in the scientific research paradigm. Imaging of small animals has been particularly useful to help understand human molecular biology and pathophysiology using rodents, especially using genetically engineered mice (GEM) with spontaneous diseases that closely mimic human diseases. Specific examples of GEM models of veterinary diseases exist, but in general, GEM for veterinary research has lagged behind human research applications. However, the development of spontaneous disease models from GEM may also hold potential for veterinary research. The imaging techniques most widely used in small-animal research are CT, PET, single-photon emission CT, MRI, and optical fluorescent and luminescent imaging.
authors: Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, Nuclear Medicine Division, Bronx, NY. Electronic address: eugene.fine@einstein.yu.edu.
authors: Eugene J
authors: EJ
authors: Fine
authors: Lawrence
authors: L
authors: Herbst
authors: Linda A
authors: LA
authors: Jelicks
authors: Wade
authors: W
authors: Koba
authors: Daniel
authors: D
authors: Theele
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D059001:Aquatic Organisms; D049628:Body Size; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000662:veterinary*; D004195:Disease Models, Animal; D006801:Humans; D011849:Radioactive Tracers; D012106:Research / Q000295:instrumentation*
chemical_list: D011849:Radioactive Tracers