title: A case of multiple extrahepatic manifestations in a patient with untreated, chronic hepatitis C virus infection.
abstract: Chronic hepatitis C virus (HCV) infection is a complex, multi-organ disorder, not just limited to the liver. Mixed cryoglobulinemia (MC) type 2 is a common extrahepatic complication, in which immunoglobulin complexes deposit in vascular endothelium. This in turn creates a diffuse inflammatory reaction, leading to a variety of disorders involving multiple systems. We report the rare case of a patient with cryoglobulinemia, cutaneous vasculitis, membroproliferative glomerulonephritis, and B cell lymphoma with a variant t(6;10) translocation in the setting of an untreated, chronic HCV infection. This case highlights the challenge associated with diagnosing and managing such a complex presentation.
authors: New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA. Electronic address: anmeilli@gmail.com.
authors: Andrew
authors: A
authors: Meillier
authors: Internal Medicine Residency Program, Department of Medicine, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
authors: Jean
authors: J
authors: McGee
authors: Internal Medicine Residency Program, Department of Medicine, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
authors: Saritha
authors: S
authors: Kartan
authors: Department of Medicine, Division of Nephrology and Hypertension, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
authors: Stuart
authors: S
authors: Baskin
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D008875:Middle Aged; D000069283:Rituximab; D014178:Translocation, Genetic; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018931:Antineoplastic Agents, Hormonal; D000069283:Rituximab; D008776:Methylprednisolone Hemisuccinate
keywords: Hepatitis C; Membroproliferative glomerulonephritis; Mixed cryoglobulinemia