title: Biotransformations of prenylated hop flavonoids for drug discovery and production.
abstract: In this review we aim to present current knowledge on biotransformation of flavonoids from hop cones with respect to type of product, catalyst and conversion. Subsequently, a comparative analysis of biological activity of prenylated hop flavonoids and their biotransformation products has been performed in order to indicate these research efforts that have good potential for application in pharmaceutical industry. There is increasing evidence that the products of biotransformation of hop prenylflavonoids, which have been little studied until recently, can be used as drugs or drug ingredients and also as standards of human drug metabolites. They can also serve as an inspiration for the design and chemical synthesis of new derivatives with higher or different biological activity. Nevertheless, much additional work, among others on determining the mechanism of action in in vivo systems, is needed to open up the way to biomedical application of these compounds.
authors: Agnieszka
authors: A
authors: Bartmańska
authors: Tomasz
authors: T
authors: Tronina
authors: Jarosław
authors: J
authors: Popłoński
authors: Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. agnieszka.bartmanska@up.wroc.pl.
authors: Ewa
authors: E
authors: Huszcza
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D001711:Biotransformation; D050071:Bone Density Conservation Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D055808:Drug Discovery; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D048789:Phytoestrogens / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D054876:Prenylation
chemical_list: D000890:Anti-Infective Agents; D019440:Anti-Obesity Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D050071:Bone Density Conservation Agents; D005419:Flavonoids; D048789:Phytoestrogens