title: An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice.
abstract: Cisplatin is used as a treatment for various types of solid tumors. Renal injury severely limits the use of cisplatin. Renal cell apoptosis, oxidative stress, and inflammation contribute to cisplatin-induced nephrotoxicity. Previously, we found that an extract of Rhodobacter sphaeroides (Lycogen™) inhibited proinflammatory cytokines and the production of nitric oxide in activated macrophages in a dextran sodium sulfate (DSS)-induced colitis model. Here, we evaluated the effect of Lycogen™, a potent anti-inflammatory agent, in mice with cisplatin-induced renal injury. We found that attenuated renal injury correlated with decreased apoptosis due to a reduction in caspase-3 expression in renal cells. Oral administration of Lycogen™ significantly reduced the expression of tumor necrosis factor-α and interleukin-1β in mice with renal injury. Lycogen™ reduces renal dysfunction in mice with cisplatin-induced renal injury. The protective effects of the treatment included blockage of the cisplatin-induced elevation in serum urea nitrogen and creatinine. Meanwhile, Lycogen™ attenuated body weight loss and significantly prolonged the survival of mice with renal injury. We propose that Lycogen™ exerts anti-inflammatory activities that represent a promising strategy for the treatment of cisplatin-induced renal injury.
authors: Wen-Wei
authors: WW
authors: Chang
authors: Jau-Jin
authors: JJ
authors: Liu
authors: Chi-Fan
authors: CF
authors: Liu
authors: Wen-Sheng
authors: WS
authors: Liu
authors: Yun-Ping
authors: YP
authors: Lim
authors: Yu-Jung
authors: YJ
authors: Cheng
authors: Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung 402, Taiwan. chlee@mail.cmu.edu.tw.
authors: Che-Hsin
authors: CH
authors: Lee
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000633:toxicity*; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000032:analysis; D053583:Interleukin-1beta / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012242:Rhodobacter sphaeroides / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D003404:Creatinine; D002945:Cisplatin