title: Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy.
abstract: Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core-shell-corona PIC nanoparticle (⊕) NP/Pt@PPC-DA as a next-generation delivery system. (⊕) NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of (⊕) NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.
authors: Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, P.R. China.
authors: Xian-Zhu
authors: XZ
authors: Yang
authors: Xiao-Jiao
authors: XJ
authors: Du
authors: Yang
authors: Y
authors: Liu
authors: Yan-Hua
authors: YH
authors: Zhu
authors: Yang-Zhong
authors: YZ
authors: Liu
authors: Ya-Ping
authors: YP
authors: Li
authors: Jun
authors: J
authors: Wang
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry; D019008:Drug Resistance, Neoplasm; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry; D010984:Platinum / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D058726:Nanoconjugates; D011355:Prodrugs; D010984:Platinum; D002945:Cisplatin
keywords: PIC nanoparticles; cisplatin resistance; drug delivery; tumor pH-responsive