title: Iontophoretic permeation of lisinopril at different current densities and drug concentrations.
abstract: OBJECTIVE
  The purpose of the present work was to assess iontophoretic permeation of Lisinopril at different current densities and concentrations for development of patient-controlled active transdermal system.
  
  
  METHODS
  In vitro iontophoretic transdermal delivery of Lisinopril across the pigskin was investigated at three different drug concentrations and three different current densities (0.25- 0.75 mA/cm2) in the donor cell of the diffusion apparatus, using cathodal iontophoresis along with the passive controls.
  
  
  RESULTS
  For passive permeation, the steady state flux significantly increased with the increasing of donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Iontophoretic transport of Lisinopril was to be found increase with current densities. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load.
  
  
  CONCLUSIONS
  The obtained results indicate that permeation rate of Lisinopril across the pigskin can be considerably enhanced, controlled or optimized by the use of Iontophoresis technique.
authors: Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
authors: Ashish
authors: A
authors: Jain
authors: Satish
authors: S
authors: Nayak
authors: Vandana
authors: V
authors: Soni
keywords: Current densities; Iontophoresis; Lisinopril; Pigskin; Transdermal drug delivery