title: Synthetic cell division system: controlling equal vs. unequal divisions by design.
abstract: Cell division is one of the most fundamental and evolutionarily conserved biological processes. Here, we report a synthetic system where we can control by design equal vs. unequal divisions. We synthesized a micro-scale inverse amphipathic droplet of which division is triggered by the increase of surface to volume ratio. Using this system, we succeeded in selectively inducing equal vs. unequal divisions of the droplet cells by adjusting the temperature or the viscosity of the solvent outside the droplet cell accordingly. Our synthetic division system may provide a platform for further development to a system where intracellular contents of the parent droplet cell could be divided into various ratios between the two daughter droplet cells to control their functions and fates.
authors: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan.
authors: Yoichi
authors: Y
authors: Sato
authors: Kazuma
authors: K
authors: Yasuhara
authors: Jun-ichi
authors: J
authors: Kikuchi
authors: Thomas N
authors: TN
authors: Sato
mesh_terms: D058045:Artificial Cells; D002455:Cell Division; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D014783:Viscosity
chemical_list: D012997:Solvents