title: A case of congenital Echovirus 11 infection acquired early in pregnancy.
abstract: Enterovirus (EV) maternal infection during pregnancy and its relation to fetal developmental pathology are seldomly described. When reported, the main manifestations of EV congenital infections are myocarditis or intra-uterine fetal demise (IUFD). No information on intrauterine Echovirus 11 infection or the effect of transplacental Echovirus 11 infection on development of the fetus has been described in literature up to date (excluding late-pregnancy infections). We report here a case of an extreme form of pulmonary hypoplasia in a neonate, characterized by total failure of development of terminal respiratory units. This pregnancy was marked by spontaneous demise of a co-twin at 14 weeks of gestation (WG), as well as by positive PCR for EV (Echovirus 11 serotype) in the amniotic fluid, performed for moderate pericardial effusion at 22WG. No signs of cardiac disease were further observed, but at 32WG a bilateral abnormal lung development was noticed After spontaneous delivery at 38WG, the child could not be resuscitated, and died at one hour after birth. Pulmonary hypoplasia is usually described following decrease intrapulmonary pressure due to oligohydramnios or compression due to intrathoracic mass of variable cause. However, rare cases of primary pulmonary hypoplasia are also described and usually of unknown etiology. The coexistence in our case of a congenital EV infection and a severe primary pulmonary hypoplasia with congenital acinar aplasia, challenges our understanding of the pathogenesis of this severe pulmonary growth arrest.
authors: Department of Obstetrics and Gynecology, AP-HP, Université Paris Sud, Antoine Béclère Hospital, Clamart, France.
authors: M
authors: M
authors: Tassin
authors: Unit of Fetal Pathology, AP-HP, Antoine Béclère Hospital, Clamart, France.
authors: J
authors: J
authors: Martinovic
authors: Laboratory of Virology EA4843, Enterovirus and Parechovirus National Reference Center - Associated Laboratory, Clermont-Ferrand University Hospital, France.
authors: A
authors: A
authors: Mirand
authors: Laboratory of Virology EA4843, Enterovirus and Parechovirus National Reference Center - Associated Laboratory, Clermont-Ferrand University Hospital, France.
authors: H
authors: H
authors: Peigue-Lafeuille
authors: Department of Obstetrics and Gynecology, Foch Hospital, Suresnes, France; Collège Français d'Echographie Foetale, France.
authors: O
authors: O
authors: Picone
authors: Department of Obstetrics and Gynecology, AP-HP, Université Paris Sud, Antoine Béclère Hospital, Clamart, France.
authors: A
authors: A
authors: Benachi
authors: INSERM UMR-S996, Université Paris Sud, AP-HP, Virology Department, Hôpital Paul Brousse, Villejuif, France. Electronic address: christelle.vauloup@abc.aphp.fr.
authors: C
authors: C
authors: Vauloup-Fellous
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D004457:Echovirus Infections / Q000150:complications* / Q000151:congenital* / Q000473:pathology / Q000821:virology; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008168:Lung / Q000002:abnormalities* / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
keywords: Congenital acinar aplasia; Congenital infection; Enterovirus; Pulmonary hypoplasia