title: Managing ulcerative colitis by increasing hydrogen production via oral administration of Acarbose.
abstract: The objective of the study was to investigate ulcerative colitis management through oral administration of acarbose. Acarbose has gained importance as a drug used widely to treat Diabetes Mellitus Type 2,as it acts on the small intestine by competitively inhibiting enzymes that delay the release of glucose from complex carbohydrates, thereby specifically reducing postprandial glucose excursion. The main side-effect of treatment with Acarbose, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in considerable amounts of hydrogen. We found that the enteric benefits of Acarbose are partly due to be their ability to neutralise oxidative stress via increased production of H₂ in the gastrointestinal tract. Therefore, some symptoms of ulcerative colitis in human beings can be ameliorated by Acarbose.
authors: Department of Digestion Internal Medicine, the First Affiliated Hospital, Soochow University, Su Zhou, 215006, P.R. China.
authors: Jian-Hong
authors: JH
authors: Zhu
authors: Department of Digestion Internal Medicine, the First Affiliated Hospital, Soochow University, Su Zhou, 215006, P.R. China.
authors: De-Qing
authors: DQ
authors: Zhang
authors: Department of Digestion Internal Medicine, the First Affiliated Hospital, Soochow University, Su Zhou, 215006, P.R. China.
authors: Wei-Chang
authors: WC
authors: Chen
mesh_terms: D020909:Acarbose / Q000494:pharmacology / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D006859:Hydrogen / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D007004:Hypoglycemic Agents; D006859:Hydrogen; D020909:Acarbose
keywords: Acarbose; Ulcerative colitis; hydrogen