title: [Drunkenness caused by isoniazid in a tuberculosis patient with extrapulmonary lesions on hemodialysis: a case report].
abstract: The patient was a 55-year-old man who had been on hemodialysis for 6 years for diabetic nephropathy. He was clinically diagnosed with pulmonary tuberculosis with extrapulmonary lesion after 3 years of chronic fever. His fever subsided immediately after the beginning of antituberculosis drug therapy and the antituberculosis drugs were discontinued 3 days after the initiation of the therapy. He experienced a sense of drunkenness when he received isoniazid, apparently not in association with any of the other antituberculosis drugs given. His blood trough concentration of isoniazid was nearly equal to the usual peak levels measured in patients with normal renal function. Isoniazid is often prescribed for patients with chronic renal failure without dose-reduction, because of its hepatic metabolism. But blood level of INH was found to accumulate at high levels in this patient. The high blood concentration of isoniazid in this patient with chronic renal failure may have elicited his neurological side effect.
authors: Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital. m-saiki1202@ych.pref.yamanashi.jp
authors: Masafumi
authors: M
authors: Saiki
authors: Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital.
authors: Takayuki
authors: T
authors: Honda
authors: Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital.
authors: Yusuke
authors: Y
authors: Sogami
authors: Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital.
authors: Kazuhiro
authors: K
authors: Fukasawa
authors: Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital.
authors: Yoshihiro
authors: Y
authors: Miyashita
authors: Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University.
authors: Kazumi
authors: K
authors: Sano
mesh_terms: D000435:Alcoholic Intoxication / Q000209:etiology*; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid