title: Therapeutic effects of garenoxacin in murine experimental secondary pneumonia by Streptococcus pneumoniae after influenza virus infection.
abstract: In a pneumococcal pneumonia murine model following influenza virus infection, garenoxacin was more effective than other fluoroquinolones and demonstrated high levels of bacterial eradication in the lung, low mortality, and potent histopathological improvements. Garenoxacin could potentially be used for the treatment of secondary pneumococcal pneumonia following influenza.
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan. Electronic address: yoshiko_fukuda@toyama-chemical.co.jp.
authors: Yoshiko
authors: Y
authors: Fukuda
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan.
authors: Yuri
authors: Y
authors: Furuya
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan.
authors: Yusuke
authors: Y
authors: Nozaki
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan.
authors: Masahiro
authors: M
authors: Takahata
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan.
authors: Nobuhiko
authors: N
authors: Nomura
authors: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan.
authors: Junichi
authors: J
authors: Mitsuyama
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D060085:Coinfection; D004195:Disease Models, Animal; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D009980:Influenza A virus; D008168:Lung / Q000382:microbiology / Q000473:pathology / Q000821:virology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000150:complications*; D011018:Pneumonia, Pneumococcal / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D020545:Respiratory Mucosa / Q000382:microbiology / Q000648:ultrastructure / Q000821:virology; D013296:Streptococcus pneumoniae
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C419689:garenoxacin
keywords: Garenoxacin; In vivo efficacy; Influenza; Secondary bacterial pneumonia; Streptococcus pneumoniae