title: Role of the trigeminal system on posterior communicating artery remodelization after bilateral common carotid artery ligation.
abstract: OBJECTIVE
  To examine whether or not there is a possible relationship between the neuron density of trigeminal ganglion (TGG) and the severity of posterior communicating artery (PComA) vasodilation values after permanent bilateral common carotid artery ligation (BCCAL).
  
  
  METHODS
  This study included 25 rabbits. Both the common carotid arteries of 20 rabbits were explored and denervated. Five animals served as controls. Permanent BCCAL was applied in 15 of the 20 rabbits, and the other 5 were used as the SHAM group without ligation. All animals were followed for 2 months and then sacrificed. Their brains and cranial nerves were extracted and fixed in 10% formalin solution. The relationship between PComA vasodilation values and TGG neuron densities were compared.
  
  
  RESULTS
  Elongation, convolution and enlargement were detected in all the basilar arteries of all ligated animals and 2 from the SHAM group. On histopathogical examination vascular wall thinning, luminal enlargement, flattened inner elastic membrane, flattened vessel muscle cells, endothelial desquamation and intimal erosions were detected. An inverse relationship was discovered between the neuron density of TGG and the severity of PComA vasodilation index.
  
  
  CONCLUSIONS
  BCCAL may lead to important beneficial and hazardous histomorphological changes at the posterior communicating artery. The high neuron density of TGG may provide a beneficial effect by facilitating PComA enlargement via its vasodilatory properties for the increase of decreased cerebral circulation, although this situation may be hazardous for certain subjects with congenital or acquired cerebrovascular pathologies.
authors: Department of Neurology, Ataturk University Medical Faculty, Erzurum.
authors: Recep
authors: R
authors: Aygul
authors: Department of Neurosurgery, Ataturk University Medical Faculty, Erzurum.
authors: Mehmet Dumlu
authors: MD
authors: Aydin
authors: Department of Neurology, Sakarya University Medical Faculty, Sakarya, Turkey.
authors: Dilcan
authors: D
authors: Kotan
authors: Department of Neurology, Ataturk University Medical Faculty, Erzurum.
authors: Recep
authors: R
authors: Demir
authors: Department of Neurology, Ataturk University Medical Faculty, Erzurum.
authors: Hizir
authors: H
authors: Ulvi
authors: Department of Neurosurgery, Silivri State Hopsital, Istanbul.
authors: Mustafa
authors: M
authors: Karalar
authors: Department of Pathology, Ataturk University Medical Faculty, Erzurum.
authors: Nesrin Gursan
authors: NG
authors: Nalbantoglu
authors: Department of Neurosurgery, Yüzüncü Yil University Medical Faculty, Van, Turkey.
authors: Metehan
authors: M
authors: Eseoglu
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000294:innervation / Q000473:pathology / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000294:innervation* / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003714:Denervation; D004195:Disease Models, Animal; D008026:Ligation; D020769:Posterior Cerebral Artery / Q000294:innervation* / Q000473:pathology* / Q000503:physiopathology; D011817:Rabbits; D012668:Trigeminal Ganglion / Q000166:cytology / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology