title: Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata.
abstract: Selaginpulvilins A-D (1-4), four new phenols with an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton, together with four known selaginellins (5-8) were isolated from Selaginella pulvinata. Their structures were elucidated by spectroscopic analysis and chemical correlation. The structure of 1 was confirmed by single-crystal X-ray diffraction. Compounds 1-8 exhibited remarkable inhibitory activities (IC50 values in the range of 0.11-5.13 μM) against phosphodiesterase-4 (PDE4), a drug target for the treatment of asthma and chronic obstructive pulmonary disease.
authors: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, Guangdong 510006, P. R. China.
authors: Xin
authors: X
authors: Liu
authors: Hai-Bin
authors: HB
authors: Luo
authors: Yi-You
authors: YY
authors: Huang
authors: Jing-Mei
authors: JM
authors: Bao
authors: Gui-Hua
authors: GH
authors: Tang
authors: Yun-Yun
authors: YY
authors: Chen
authors: Jun
authors: J
authors: Wang
authors: Sheng
authors: S
authors: Yin
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D058988:Phosphodiesterase 4 Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032503:Selaginellaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C588129:9,9-diphenyl-1-(phenylethynyl)-9H-fluorene; D001688:Biological Products; D005449:Fluorenes; D058988:Phosphodiesterase 4 Inhibitors; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4