title: Preclinical atherosclerosis in patients with prolactinoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of hyperprolactinemia on body fat, insulin sensitivity, inflammatory markers, and cardiovascular risk in patients with prolactinoma.
  
  
  METHODS
  The study included 35 untreated hyperprolactinemic patients with pituitary adenomas, and 36 age-, gender-, and body mass index (BMI)-matched healthy controls without any known disease. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and heart-type fatty acid binding protein (H-FABP) levels were measured. Waist and hip circumference (WC and HC) were measured in all the participants. The body fat percentage was measured, and the visceral fat and abdominal fat percentages were measured via bioelectrical impedance (BIA). In addition, carotid intima media thickness (CIMT) was measured using high-resolution B-mode ultrasound.
  
  
  RESULTS
  The serum glucose level, HOMA-IR, triglyceride level, and SC were significantly higher in the patient group than in the control group. The hs-CRP level and CIMT were significantly higher in the hyperprolactinemic patients. Visceral and truncal fat percentages were significantly higher in the patients with prolactinoma. H-FABP levels were similar in the 2 groups, and there was a positive correlation between the prolactin (PRL) and H-FABP protein levels.
  
  
  CONCLUSIONS
  Based on the present findings, hyperprolactinemia is associated with preclinical atherosclerosis and metabolic abnormalities. Patients with hyperprolactinemia might experience cardiovascular disease in the long term. Metabolic control should be achieved in addition to the control of hyperprolactinemia in the clinical management of patients diagnosed with prolactinoma.
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Muyesser Sayki
authors: MS
authors: Arslan
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Oya
authors: O
authors: Topaloglu
authors: School of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara University, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Sahin
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Esra
authors: E
authors: Tutal
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Askin
authors: A
authors: Gungunes
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Evrim
authors: E
authors: Cakir
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Ilknur Unsal
authors: IU
authors: Ozturk
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Basak
authors: B
authors: Karbek
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Bekir
authors: B
authors: Ucan
authors: Department of Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Zeynep
authors: Z
authors: Ginis
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Erman
authors: E
authors: Cakal
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Ozbek
authors: Department of Endocrinology and Metabolic Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey School of Medicine (Kastamonu), Hacettepe University, Ankara-Turkey.
authors: Tuncay
authors: T
authors: Delibasi
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015175:Prolactinoma / Q000150:complications*
chemical_list: D050556:Fatty Acid-Binding Proteins