title: Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke.
abstract: The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (χ (2)) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (χ (2) = 7.25, P = 0.007, OR = 1.78, 95%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke.
authors: Research Centre for Neuroscience and Department of Neurology, Jilin University First Hospital, 71 Xinmin Street, Changchun, 130021, China.
authors: Yumei
authors: Y
authors: Yang
authors: Danhua
authors: D
authors: Du
authors: Peng
authors: P
authors: Gao
authors: Xuan
authors: X
authors: Zhang
authors: Ning
authors: N
authors: Wu
authors: Feng
authors: F
authors: Wang
authors: Zhenqi
authors: Z
authors: Wang
authors: Lin
authors: L
authors: Ye
authors: Jiang
authors: J
authors: Wu
authors: Ian L
authors: IL
authors: Megson
authors: Jun
authors: J
authors: Wei