title: β-Cyclodextrin-bearing gold glyconanoparticles for the development of site specific drug delivery systems.
abstract: Three novel gold nanoparticles containing multiple long, flexible linkers decorated with lactose, β-cyclodextrin, and both simultaneously have been prepared. The interaction of such nanoparticles with β-d-galactose-recognizing lectins peanut agglutinin (PNA) and human galectin-3 (Gal-3) was demonstrated by UV-vis studies. Gal-3 is well-known to be overexpressed in several human tumors and can act as a biorecognizable target. This technique also allowed us to estimate their loading capability toward the anticancer drug methotrexate (MTX). Both results make these glyconanoparticles potential site-specific delivery systems for anticancer drugs.
authors: Department of Chemistry and Physics, University of Almería , Carretera de Sacramento s/n, 04120 Almería, Spain.
authors: Ahmet
authors: A
authors: Aykaç
authors: Manuel C
authors: MC
authors: Martos-Maldonado
authors: Juan M
authors: JM
authors: Casas-Solvas
authors: Indalecio
authors: I
authors: Quesada-Soriano
authors: Federico
authors: F
authors: García-Maroto
authors: Luís
authors: L
authors: García-Fuentes
authors: Antonio
authors: A
authors: Vargas-Berenguel
mesh_terms: D000373:Agglutinins / Q000737:chemistry; D001798:Blood Proteins; D016503:Drug Delivery Systems; D005690:Galactose / Q000737:chemistry; D037502:Galectin 3 / Q000737:chemistry; D037161:Galectins; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000373:Agglutinins; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D047392:beta-Cyclodextrins; D006046:Gold; C031215:betadex; D005690:Galactose