title: Nosocomial outbreak of a multiresistant Acinetobacter baumannii expressing OXA-23 carbapenemase in Spain.
abstract: Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 50 patients between July 2011 and July 2012 at the University Hospital A Coruña (NW Spain). These multidrug-resistant isolates, which belonged to a single clone, remained only susceptible to tigecycline, minocycline, and colistin and produced the carbapenem-hydrolyzing oxacillinase, OXA-23. This is the first reported outbreak of OXA-23-producing A. baumannii isolates in Spain.
authors: 1 Microbiology Department, Biomedical Research Institute-INIBIC, University Hospital A Coruña , A Coruña, Spain .
authors: María
authors: M
authors: Merino
authors: Margarita
authors: M
authors: Poza
authors: Ignasi
authors: I
authors: Roca
authors: María José
authors: MJ
authors: Barba
authors: Maria Dolores
authors: MD
authors: Sousa
authors: Jordi
authors: J
authors: Vila
authors: Germán
authors: G
authors: Bou
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000472:pathogenicity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015780:Carbapenems / Q000378:metabolism / Q000627:therapeutic use; D002999:Clone Cells; D003091:Colistin / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D015870:Gene Expression; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives / Q000627:therapeutic use; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000078304:Tigecycline; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases; D008911:Minocycline; D003091:Colistin