title: Collagen as a double-edged sword in tumor progression.
abstract: It has been recognized that cancer is not merely a disease of tumor cells, but a disease of imbalance, in which stromal cells and tumor microenvironment play crucial roles. Extracellular matrix (ECM) as the most abundant component in tumor microenvironment can regulate tumor cell behaviors and tissue tension homeostasis. Collagen constitutes the scaffold of tumor microenvironment and affects tumor microenvironment such that it regulates ECM remodeling by collagen degradation and re-deposition, and promotes tumor infiltration, angiogenesis, invasion and migration. While collagen was traditionally regarded as a passive barrier to resist tumor cells, it is now evident that collagen is also actively involved in promoting tumor progression. Collagen changes in tumor microenvironment release biomechanical signals, which are sensed by both tumor cells and stromal cells, trigger a cascade of biological events. In this work, we discuss how collagen can be a double-edged sword in tumor progression, both inhibiting and promoting tumor progression at different stages of cancer development.
authors: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China.
authors: Min
authors: M
authors: Fang
authors: Jingping
authors: J
authors: Yuan
authors: Chunwei
authors: C
authors: Peng
authors: Yan
authors: Y
authors: Li
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000502:physiology*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology*; D009389:Neovascularization, Pathologic / Q000209:etiology; D008249:Protein-Lysine 6-Oxidase / Q000502:physiology
chemical_list: D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D020782:Matrix Metalloproteinases