title: Cytotoxic activity of new phenolic compounds from Vietnamese Caesalpinia sappan.
abstract: Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis.
authors: Faculty of Chemistry, University of Science, Vietnam National University.
authors: Tran Manh
authors: TM
authors: Hung
authors: Nguyen Xuan
authors: NX
authors: Hai
authors: Nguyen Trung
authors: NT
authors: Nhan
authors: Ton That
authors: TT
authors: Quang
authors: Tran Le
authors: TL
authors: Quan
authors: To Dao
authors: TD
authors: Cuong
authors: Nguyen Hai
authors: NH
authors: Dang
authors: Nguyen Tien
authors: NT
authors: Dat
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D014744:Vietnam
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D010636:Phenols; D010936:Plant Extracts