title: [Experimental evaluation of actoprotective activity of nitrogen-containing heterocyclic compounds derivatives in extreme conditions].
abstract: In experiments on nonlinear male mice the ability of new derivatives of nitrogen-containing heterocyclic compounds to increase the physical working capacity in conditions of hyperthermia, hypothermia and acute normobaric hypoxia and hypercapnia has been investigated. It is established, that pyridine derivative IBHF-11 has more expressed positive action in the said conditions. It provided increase of the working capacity of animals at all kinds of extreme influence, and the value of positive action was comparable, and in conditions of acute normobaric hypoxia and hypercapnia exceeded those at the reference products bemitil and bromantan.
authors: E G
authors: EG
authors: Tsublova
authors: T G
authors: TG
authors: Ivanova
authors: T N
authors: TN
authors: Ivanova
authors: V V
authors: VV
authors: Iasnetsov
mesh_terms: D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005334:Fever / Q000188:drug therapy* / Q000503:physiopathology; D006935:Hypercapnia / Q000188:drug therapy* / Q000503:physiopathology; D007035:Hypothermia / Q000188:drug therapy* / Q000503:physiopathology; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D010807:Physical Endurance / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; C049825:bemethyl; D000547:Amantadine; C085955:bromantane