title: Resolution of acute inflammation in the lung.
abstract: Acute inflammation in the lung is essential to health. So too is its resolution. In response to invading microbes, noxious stimuli, or tissue injury, an acute inflammatory response is mounted to protect the host. To limit inflammation and prevent collateral injury of healthy, uninvolved tissue, the lung orchestrates the formation of specialized proresolving mediators, specifically lipoxins, resolvins, protectins, and maresins. These immunoresolvents are agonists for resolution that interact with specific receptors on leukocytes and structural cells to blunt further inflammation and promote catabasis. This process appears to be defective in several common lung diseases that are characterized by excess or chronic inflammation. Here, we review the molecular and cellular effectors of resolution of acute inflammation in the lung.
authors: Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; email: blevy@partners.org.
authors: Bruce D
authors: BD
authors: Levy
authors: Charles N
authors: CN
authors: Serhan
mesh_terms: D000208:Acute Disease; D000818:Animals; D001249:Asthma / Q000473:pathology; D018957:CD59 Antigens / Q000502:physiology; D004281:Docosahexaenoic Acids / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D044045:Lipoxins / Q000502:physiology; D011014:Pneumonia / Q000473:pathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology
chemical_list: C535211:7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid; D018957:CD59 Antigens; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators; D044045:Lipoxins; D004281:Docosahexaenoic Acids