title: Caesappin A and B, two novel protosappanins from Caesalpinia sappan L.
abstract: Two novel protosappanins, named Caesappin A (1) and B (2), along with three known protosappanins were isolated from Caesalpinia sappan L. Caesappin A is a new type protosappanin with a seven-membered ring fusing an acetal-type section. Compound 4 was isolated from the genus Caesalpinia for the first time. The structures were elucidated on the basis of spectral analysis and the absolute configuration was determined by the ECD experiment coupled with calculated ECD spectra. Their cytotoxic activities were evaluated using MTT assay.
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmaceutical Engineering, Hunan University of Science and Engineering, Yongzhou 425199, China.
authors: Zheng
authors: Z
authors: Wang
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors: Jian-Bo
authors: JB
authors: Sun
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors: Wei
authors: W
authors: Qu
authors: Institute of Botany, Jiangsu Province and Chinese Academy of Science, Nanjing 210014, China.
authors: Fu-Qin
authors: FQ
authors: Guan
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors: Lin-Zhen
authors: LZ
authors: Li
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jyliang08@126.com.
authors: Jing-Yu
authors: JY
authors: Liang
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D029911:Caesalpinia / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D006575:Heterocyclic Compounds, 3-Ring; D010636:Phenols; D010936:Plant Extracts; C090723:protosappanin A; D000096:Acetone
keywords: Caesalpinia sappan L.; Caesappin A and B; Cytotoxic activity; Protosappanin