title: Comparison of surgical outcomes between papillary thyroid cancer patients treated with the Harmonic ACE scalpel and LigaSure Precise instrument during conventional thyroidectomy: a single-blind prospective randomized controlled trial.
abstract: BACKGROUND
  The aim of this study was to evaluate the safety and efficacy of thyroidectomy using the Harmonic ACE scalpel (HS) or the LigaSure Precise (LS) instrument in conventional thyroidectomy.
  
  
  METHODS
  A prospective, randomized controlled trial was performed. Between August 2011 and June 2012, 832 patients who required thyroidectomy for papillary thyroid cancer were randomized into groups treated with either the HS or the LS instrument. Operative time and surgical morbidities were analyzed.
  
  
  RESULTS
  A total of 320 patients (HS group, N = 164; LS instrument group, N = 156) were randomized for analysis according to the intention-to-treat principle. There were no statistically significant differences in the operative times (HS group versus LS instrument group: 71.93 ± 18.26 versus 75.15 ± 20.13; P = 0.423), postoperative transient hypoparathyroidism (13.4% versus 14.1%; P = 0.858), and permanent recurrent laryngeal nerve injuries between the two groups.
  
  
  CONCLUSIONS
  In this study, both hemostatic devices were safe and effective in terms of postoperative results and complications without any differences.
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Hee Yong
authors: HY
authors: Kwak
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Byung Joo
authors: BJ
authors: Chae
authors: Department of Medical Life Sciences, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Yong-Gyu
authors: YG
authors: Park
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Sang Hoon
authors: SH
authors: Kim
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Eun Young
authors: EY
authors: Chang
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Eun Jin
authors: EJ
authors: Kim
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Byung Joo
authors: BJ
authors: Song
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Sang Seol
authors: SS
authors: Jung
authors: Department of Surgery, College of Medicine, Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea. Electronic address: drbae@catholic.ac.kr.
authors: Ja Seong
authors: JS
authors: Bae
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000601:surgery*; D002291:Carcinoma, Papillary; D015897:Comorbidity; D004564:Electrocoagulation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology; D011446:Prospective Studies; D016037:Single-Blind Method; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000209:etiology; D055815:Young Adult
keywords: Clinical trials; Harmonic scalpel; Hemostasis; LigaSure; Thyroid cancer; Thyroidectomy