title: Auditory Brainstem Responses (ABR) changes in children treated with high doses cisplatin.
abstract: BACKGROUND
  Cisplatin can cause cochlear damage by oxidative stress in hair cells, but there are few studies regarding toxicity in the central auditory pathways.
  
  
  OBJECTIVE
  To study cisplatin neurotoxicity in the central auditory pathways in children treated with high doses cisplatin for solid malignant tumors.
  
  
  METHODS
  Thirteen children (Group S) aged 3-19 years who had been treated with cisplatin (60-120 mg/m(2)/cycle) were studied using evoked otoacoustic emissions (EOA), conventional auditory evaluation and auditory brainstem response (ABR). Thirteen normal children matched for age and sex composed the control group (Group C).
  
  
  RESULTS
  Group S - 7.5% percent of ears showed enlargement of latencies of waves I and V, and 3.8% of wave III. Six ears (23%) showed enlarged interpeak intervals. Four ears showed increased interpeak I-III and two showed increased interpeak III-V. The results were compared using the Mann-Whitney test. Interpeak III-V differed significantly between groups S and C when only the left ears were considered. EOA results were normal in both groups.
  
  
  CONCLUSIONS
  Abnormal values in the interpeak I-III associated with normal distortion product OEA suggest neurotoxicity in the brainstem pathways. The statistical significance reached only in the left ear may be due to small number of cases studied.
authors: Lucas Moura
authors: LM
authors: Viana
authors: Andre L L
authors: AL
authors: Sampaio
authors: Nilda Agostinho
authors: NA
authors: Maia
authors: Rozania M P
authors: RM
authors: Junqueira
authors: Alessandra Ramos
authors: AR
authors: Venosa
authors: Carlos Augusto C P
authors: CA
authors: Oliveira
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001306:Auditory Pathways / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin