title: Anal fissures in infants may be a pathognomonic sign of infants with cow's milk allergy.
abstract: OBJECTIVE
  To study the association between analfissures and cow's milk allergy (CMA) in infants. METHODS AND METHOD: In a prospective study, 72 confirmed cases of CMA in infants were examined for anal fissure by pediatricians with five years' experience. A positive finding was defined as when an anal fissure was detected by at least two out of three examiners.
  
  
  RESULTS
  Of infants with CMA with and without gastrointestinal GI symptoms, 79% and 83% had anal fissures, respectively The prevalence of anal fissure in these infants is significantly higher than in normal infants.
  
  
  CONCLUSIONS
  Anal fissure may be a pathognomonic sign of cow's milk allergy in infants.
authors: Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. pipop.jir@mahidol.ac.th
authors: Pipop
authors: P
authors: Jirapinyo
authors: Narumon
authors: N
authors: Densupsoontorn
authors: Channagarn
authors: C
authors: Kangwanpornsiri
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005401:Fissure in Ano / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications* / Q000473:pathology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors