title: MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis.
abstract: Mammalian noncoding microRNAs (miRNAs) are suggested to be involved in immune system function. We found that miR-155 expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). Knockdown of miR-155 resulted in low Th1 and Th17 cells and mild EAE, and its overexpression led to more Th1 and Th17 cells and severe EAE. MiR-155 promoted the development of inflammatory Th17/Th1 cell subsets. These findings demonstrate that miR-155 confers susceptibility to EAE by affecting inflammatory T cell responses and can be a new target for therapy of multiple sclerosis.
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China.
authors: Jing
authors: J
authors: Zhang
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China.
authors: Ye
authors: Y
authors: Cheng
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China.
authors: Wei
authors: W
authors: Cui
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China.
authors: Meixi
authors: M
authors: Li
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China.
authors: Bin
authors: B
authors: Li
authors: The Department of Neurology of the Second Hospital of Hebei Medical University, China. Electronic address: docshuangq@126.com.
authors: Li
authors: L
authors: Guo
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D018417:Th1 Cells / Q000187:drug effects / Q000378:metabolism*; D058504:Th17 Cells / Q000187:drug effects / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology*
chemical_list: D016207:Cytokines; D004791:Enzyme Inhibitors; C524942:MIRN155 microRNA, human; D035683:MicroRNAs
keywords: Experimental autoimmune encephalomyelitis; MicroRNAs; Multiple sclerosis; Th1 cells; Th17 cells