title: Oxidative stress in children and adolescents with anxiety disorders.
abstract: BACKGROUND
  Anxiety disorders are common in children and adolescents, and they can significantly impair quality of life. Genetic, neurobiological, neurochemical, and psychological factors are believed to play a role in the etiopathogenesis of anxiety disorders. Recent evidence suggests that the pathophysiology of anxiety disorders may be associated with oxidative stress. In this study, we investigated whether there are associations between children with anxiety disorders and total oxidant/antioxidant status.
  
  
  METHODS
  The experimental group consisted of 40 patients (children and adolescents) with anxiety disorders. An age- and gender-matched control group composed of 35 healthy subjects was also assessed. Venous blood samples were collected and total antioxidative status (TAS), total oxidative status (TOS), and the oxidative stress index (OSI) were determined.
  
  
  RESULTS
  Both the TOS and the OSI of the experimental group were significantly higher than those of the control group. There were no significant differences in TAS between the experimental and control groups.
  
  
  CONCLUSIONS
  The main limitation of our study was the small sample size.
  
  
  CONCLUSIONS
  This study suggests that oxidative balance is impaired in children with anxiety disorders. Oxidative stress may play a role in the etiopathogenesis of anxiety disorders, and TOS may be a useful diagnostic tool in this context.
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors: Esra
authors: E
authors: Guney
authors: Yildirim Beyazit University Faculty of Medicine, Child and Adolescent Psychiatry Department, Ankara, Turkey. Electronic address: mehmetfceylan@yahoo.com.
authors: Mehmet
authors: M
authors: Fatih Ceylan
authors: Eskisehir State Hospital, Department of Medical Biochemistry, Eskisehir, Turkey.
authors: Aysegul
authors: A
authors: Tektas
authors: Yildirim Beyazit University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors: Murat
authors: M
authors: Alisik
authors: Yildirim Beyazit University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors: Merve
authors: M
authors: Ergin
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors: Zeynep
authors: Z
authors: Goker
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors: Gulser
authors: G
authors: Senses Dinc
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey.
authors: Onder
authors: O
authors: Ozturk
authors: Yildirim Beyazit University Faculty of Medicine, Department of Psychiatry, Ankara, Turkey.
authors: Alperen
authors: A
authors: Korkmaz
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Pediatrics, Ankara, Turkey.
authors: Sevda
authors: S
authors: Eker
authors: Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.
authors: Murat
authors: M
authors: Kizilgun
authors: Yildirim Beyazit University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors: Ozcan
authors: O
authors: Erel
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000032:analysis*; D001008:Anxiety Disorders / Q000097:blood / Q000503:physiopathology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: Anxiety disorders; Diagnostic performance; Oxidative stress; Oxidative stress index; Total antioxidative status; Total oxidative status