title: Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis.
abstract: BACKGROUND
  Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERCC2 rs1799793 and rs13181 polymorphisms with oral cancer risks.
  
  
  METHODS
  We retrieved the relevant articles from PubMed and Embase databases. Studies were selected using specific criteria. ORs and 95% CIs were calculated to assess the association. All analyses were performed using the Stata software.
  
  
  RESULTS
  Six studies were included in this meta-analysis. There were no significant associations between ERCC2 rs1799793 and rs13181 polymorphism with overall oral cancer risk. In the stratified analysis by ethnicity, no significant associations were found. In the stratified analysis by tumor type, the risk of oral leukoplakia was significant associated with rs13181 polymorphism (AC vs. AA: OR = 1.28, 95% CI = 1.01-1.62, P = 0.546 for heterogeneity, I² = 0.0%; CC vs. AA: OR = 1.94, 95% CI = 0.99-3.79, P = 0.057 for heterogeneity, I² = 60.1%; dominant model AC + CC vs. AA: OR = 1.35, 95% CI = 1.08-1.69, P = 0.303 for heterogeneity, I² = 17.6%; allele C vs. A: OR = 1.38, 95% CI = 1.04-1.82. P = 0.043 for heterogeneity, I² = 56.4%).
  
  
  CONCLUSIONS
  Rs13181 in ERCC2 gene might be associated with oral leukoplakia risk.
authors: Enjiao
authors: E
authors: Zhang
authors: Zhigang
authors: Z
authors: Cui
authors: Zhongfei
authors: Z
authors: Xu
authors: Weiyi
authors: W
authors: Duan
authors: Shaohui
authors: S
authors: Huang
authors: Xuexin
authors: X
authors: Tan
authors: Zhihua
authors: Z
authors: Yin
authors: Changfu
authors: C
authors: Sun
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Nanjing North Street, Shenyang, Heping District 110002, People's Republic of China. luli@mail.cmu.edu.cn.
authors: Li
authors: L
authors: Lu
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007972:Leukoplakia, Oral / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human