title: Isolation, pharmacological activity and structure determination of physalin B and 5β,6β-epoxyphysalin B isolated from Congolese Physalis angulata L.
abstract: Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (X) and (Y), were isolated from a crude CH2Cl2 extract of dried Congolese Physalis angulata L. plants and crystallized from acetone for structure elucidation. Compound (X) corresponds to a physalin B dimer acetone solvate hydrate (2C28H30O9·C3H6O·0.22H2O), while compound (Y) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5β,6β-epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C28H30O9·0.668C28H30O10·C3H6O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (X) and (Y).
authors: Chemistry Department, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven (Heverlee), Belgium.
authors: Peter
authors: P
authors: Mangwala Kimpende
authors: Mariano
authors: M
authors: Lusakibanza
authors: Kahunu
authors: K
authors: Mesia
authors: Lutete
authors: L
authors: Tona
authors: Monique
authors: M
authors: Tits
authors: Luc
authors: L
authors: Angenot
authors: Michel
authors: M
authors: Frédérich
authors: Luc
authors: L
authors: Van Meervelt
mesh_terms: D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D015394:Molecular Structure; D032321:Physalis / Q000737:chemistry*; D012632:Secosteroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D012632:Secosteroids; C033270:physalin B; C075425:physalin F
keywords: 5β,6β-epoxyphysalin B; Physalis angulata L.; antiplasmodial activity; crystal structure; physalin B