title: Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer's disease.
abstract: Mesenchymal stem cells (MSCs) promote functional recoveries in pathological experimental models of central nervous system (CNS) and are currently being tested in clinical trials for neurological disorders, but preventive mechanisms of placenta-derived MSCs (PD-MSCs) for Alzheimer's disease are poorly understood. Herein, we investigated the inhibitory effect of PD-MSCs on neuronal cell death and memory impairment in Aβ1-42-infused mice. After intracerebroventrical (ICV) infusion of Aβ1-42 for 14 days, the cognitive function was assessed by the Morris water maze test and passive avoidance test. Our results showed that the transplantation of PD-MSCs into Aβ1-42-infused mice significantly improved cognitive impairment, and behavioral changes attenuated the expression of APP, BACE1, and Aβ, as well as the activity of β-secretase and γ-secretase. In addition, the activation of glia cells and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by the transplantation of PD-MSCs. Furthermore, we also found that PD-MSCs downregulated the release of inflammatory cytokines as well as prevented neuronal cell death and promoted neuronal cell differentiation from neuronal progenitor cells in Aβ1-42-infused mice. These data indicate that PD-MSC mediates neuroprotection by regulating neuronal death, neurogenesis, glia cell activation in hippocampus, and altering cytokine expression, suggesting a close link between the therapeutic effects of MSCs and the damaged CNS in Alzheimer's disease.
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: H-M
authors: HM
authors: Yun
authors: 1] CHA Bio & Diostech Co., Ltd, 606-16 Yeoksam 1 dong, Gangnam gu, Seoul 135-970, Republic of Korea [2] Department of Applied Bioscience, CHA University, Gyeonggi-do 463-836, Republic of Korea.
authors: H S
authors: HS
authors: Kim
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: K-R
authors: KR
authors: Park
authors: 1] CHA Bio & Diostech Co., Ltd, 606-16 Yeoksam 1 dong, Gangnam gu, Seoul 135-970, Republic of Korea [2] Department of Applied Bioscience, CHA University, Gyeonggi-do 463-836, Republic of Korea.
authors: J M
authors: JM
authors: Shin
authors: 1] CHA Bio & Diostech Co., Ltd, 606-16 Yeoksam 1 dong, Gangnam gu, Seoul 135-970, Republic of Korea [2] Department of Applied Bioscience, CHA University, Gyeonggi-do 463-836, Republic of Korea.
authors: A R
authors: AR
authors: Kang
authors: 1] CHA Bio & Diostech Co., Ltd, 606-16 Yeoksam 1 dong, Gangnam gu, Seoul 135-970, Republic of Korea [2] Department of Applied Bioscience, CHA University, Gyeonggi-do 463-836, Republic of Korea.
authors: K
authors: K
authors: il Lee
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: S
authors: S
authors: Song
authors: College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Y-B
authors: 000000031340041X
authors: YB
authors: Kim
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: S B
authors: SB
authors: Han
authors: Department of Stem Cell Biology, School of Medicine, Konkuk University, 120 Neungdong-ro Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: H-M
authors: HM
authors: Chung
authors: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: J T
authors: JT
authors: Hong
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D008813:Mice, Inbred ICR; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy
chemical_list: D016229:Amyloid beta-Peptides