title: [New aspects of the pathogenesis and classification of basal-like breast carcinoma].
abstract: New approaches to the molecular classification of breast cancer are considered. Particular emphasis is placed on its basal-like type that belongs to the most aggressive and prognostically unfavorable forms of tumor. The origin of this type of breast cancer is the subject of intense debate in the scientific community. There are three basic theories that basal-like breast carcinoma may arise from the stem or myoepithelial cells and through dedifferentiation via epithelial-mesenchymal transformation. The theory of its origin from stem/progenitor cells is most valid and proven.
authors: M Z
authors: MZ
authors: Gorelik
authors: Iu Iu
authors: IuIu
authors: Andreeva
authors: L É
authors: LÉ
authors: Zavalishina
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D054337:Cell Dedifferentiation; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D018295:Neoplasms, Basal Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology