title: MicroRNAs: Suggested role in pituitary adenoma pathogenesis.
abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules that represent a major class of molecular regulators. miRNAs have been implicated in the pathogenesis of several human tumors, including pituitary adenomas. Altered expression of miRNAs has been described in pituitary adenomas, and specific miRNA signatures are related to clinical and therapeutic characteristics of the tumors. The data suggest that miRNAs influence various genes known to be associated with the pathogenesis of pituitary adenomas and in this review we summarize these currently available studies focusing on miRNAs in pituitary adenomas.
authors: Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: M R
authors: MR
authors: Gadelha
authors: L
authors: L
authors: Kasuki
authors: J
authors: J
authors: Dénes
authors: G
authors: G
authors: Trivellin
authors: M
authors: M
authors: Korbonits
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000473:pathology*; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis
chemical_list: D035683:MicroRNAs