title: Determination of 23 phthalic acid esters in food by liquid chromatography tandem mass spectrometry.
abstract: A rapid and sensitive method was developed for the determination of 23 phthalates in food samples including milk-based products, distilled liquor, wine, beverage, grain, meat, oil, biscuit (cookie), and canned food by liquid chromatography tandem mass spectrometry (LC-MS/MS). Liquid samples were exacted by acetonitrile, while solid samples were prepared by QuEChERS or glass-based SPE methods. The 23 phthalates were separated on Poroshell 120 EC-C18 column and followed by positive electrospray ionization as well as multi-reaction monitoring provided by a triple-quadrupole tandem mass spectrometer. To reduce contamination, the plastic materials were avoided in sample handling and preparation . The LODs were between 0.8 and 15 μg kg(-1) and LOQs were between 10 and 100 μg kg(-1). By using different concentrations: 100, 500, and 1000 μg kg(-1)) for DINP and DIDP; 50, 100, and 1000 μg kg(-1) for other 21 phthalate compounds, the spiked recoveries were within 75.5-115.2% and the relative standard deviations (RSDs) were in the range of 3.2-18.9%. The proposed protocol was then applied to the analysis of 623 real samples collected from the two sides of the Taiwan Straits, and the DEHP was found in almost all samples tested in this study, with levels ranging from 0.02 to 2685 mg kg(-1). The present study demonstrated a rapid, sensitive, and accurate method for determining 23 phthalates in foodstuffs.
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China. Electronic address: xudm@xmciq.gov.cn.
authors: Dunming
authors: D
authors: Xu
authors: Animal Plants & Foods Inspection and Quarantine Technical Center, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
authors: Xiaojun
authors: X
authors: Deng
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Enhua
authors: E
authors: Fang
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Xianghua
authors: X
authors: Zheng
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Yu
authors: Y
authors: Zhou
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Liyi
authors: L
authors: Lin
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Luping
authors: L
authors: Chen
authors: Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors: Ming
authors: M
authors: Wu
authors: Hunan Academy of Inspection and Quarantine, Changsha 410007, China.
authors: Zhiqiang
authors: Z
authors: Huang
mesh_terms: D000818:Animals; D002138:Calibration; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D057230:Limit of Detection; D010795:Phthalic Acids / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
chemical_list: D010795:Phthalic Acids; C032279:phthalic acid
keywords: Foodstuff; Liquid chromatography tandem mass spectrometry (LC–MS/MS; Phthalic acid esters (PAEs); QuEChERS; SPE