title: Gelucire based in situ gelling emulsions: a potential carrier for sustained stomach specific delivery of gastric irritant drugs.
abstract: Non steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications to the geriatric patients for the treatment of arthritis and other painful disorders. The major side effects of NSAIDs are related to their effects on the stomach and bowels. The present study concerns assessment of the potential of liquid in situ gelling emulsion formulations (emulgels) as patient compliant stomach specific sustained release carrier for the delivery of highly gastric irritant drug, Piroxicam. Emulgels were prepared, without using any emulgent, by mixing different concentrations of molten Gelucire 39/01 with low viscosity sodium alginate solution prepared in deionized water at 50°C. CaCO₃ was used as buoyancy imparting as well as crosslinking agent. Emulgels so prepared were homogenous, physically stable, and rapidly formed into buoyant gelled mass when exposed to simulated gastric fluid (SGF, pH 1.2). Drug release studies carried out in SGF revealed significant retardation (P < 0.05) of Piroxicam release from emulgels compared to conventional in situ gelling formulations prepared without Gelucire 39/01. Pharmacodynamic studies carried out in albino rats revealed significantly increased analgesic/anti-inflammatory response from in situ emulgels compared to conventional in situ gelling formulations. Further, in vivo toxicity studies carried out in albino rats revealed no signs of gastric ulceration upon prolonged dosing.
authors: Department of Pharmaceutics, College of Pharmacy, IFTM, Moradabad Uttar Pradesh 244001, India.
authors: Ashwin
authors: A
authors: Saxena
authors: Arun K
authors: AK
authors: Mishra
authors: Navneet
authors: N
authors: Verma
authors: Shiv S
authors: SS
authors: Bhattacharya
authors: Amitava
authors: A
authors: Ghosh
authors: Anurag
authors: A
authors: Verma
authors: Jayanta K
authors: JK
authors: Pandit
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000008:administration & dosage; D000818:Animals; D001168:Arthritis / Q000188:drug therapy; D016503:Drug Delivery Systems; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D010146:Pain / Q000188:drug therapy; D010894:Piroxicam / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry; D014783:Viscosity
chemical_list: D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D014280:Triglycerides; D010894:Piroxicam; D020723:Glucuronic Acid