title: Evaluation of VEGF-C and tumor markers in bronchoalveolar lavage fluid for lung cancer diagnosis.
abstract: A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.
authors: 1] Department of Respiratory Medicine, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China [2] Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China [3].
authors: Chao
authors: C
authors: Cao
authors: Zhong-Bo
authors: ZB
authors: Chen
authors: Shi-Fang
authors: SF
authors: Sun
authors: Yi-Ming
authors: YM
authors: Yu
authors: Qun-Li
authors: QL
authors: Ding
authors: Zai-Chun
authors: ZC
authors: Deng
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D006801:Humans; D053539:Keratin-19 / Q000378:metabolism; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D060787:Neoplasm Grading; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012372:ROC Curve; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D042582:Vascular Endothelial Growth Factor C; C102012:antigen CYFRA21.1; D010751:Phosphopyruvate Hydratase