title: [Efficacy of acitretin in IgA pemphigus].
abstract: BACKGROUND
  IgA pemphigus is a particular entity among autoimmune blistering intraepidermal diseases. IgA pemphigus is subdivided into two types: intraepidermal neutrophilic IgA dermatosis and subcorneal pustular dermatosis.
  
  
  METHODS
  We report the case of an 82-year-old woman with intraepidermal neutrophilic IgA pemphigus associated with IgA gammopathy. The histopathological findings were unusual, with numerous large subcorneal pustules, a few pustules in the stratum spinosum, and basal IgA deposition. A favourable outcome was achieved with acitretin.
  
  
  CONCLUSIONS
  This observation is significant in that it highlights the difficulty of classification of IgA pemphigus, which is currently based on clinical and histopathological findings. There is currently no therapeutic consensus attitude but simply a set of empirical data.
authors: Service de dermatologie, hôpital Saint-Vincent-de-Paul, université catholique de Lille, boulevard Belfort, BP 387, 59020 Lille cedex, France. Electronic address: astrid.bellissen@hotmail.fr.
authors: A
authors: A
authors: Bellissen
authors: D
authors: D
authors: Lebas
authors: M
authors: M
authors: Wantz
authors: P
authors: P
authors: Gosset
authors: A
authors: A
authors: Lasek
authors: P
authors: P
authors: Modiano
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000369:Aged, 80 and over; D001623:Betamethasone / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D003622:Dapsone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications*; D020556:Neutrophil Infiltration; D010392:Pemphigus / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000276:immunology / Q000473:pathology
chemical_list: D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D007641:Keratolytic Agents; D003622:Dapsone; D002097:C-Reactive Protein; D001623:Betamethasone; D017255:Acitretin
keywords: Basal IgA deposits; Dermatose neutrophilique à IgA; Dépôt d’ IgA basale; IgA pemphigus; Intraepidermal neutrophilic IgA pemphigus; Pemphigus à IgA