title: Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their α-glucosidase inhibitory activities.
abstract: A new phenylpropanoid glycoside, designated Scrophuside (1) and two new iridoid glycosides, respectively named Ningposide I (2) and Ningposide II (3), along with twelve known (4-15) iridoid and phenylpropanoid glycosides were obtained from the roots of Scrophularia ningpoensis Hemsl. by various chromatographic techniques and their structures were established through chemical methods and spectroscopic analyses. Most of the obtained compounds have been screened for α-Glucosidase inhibitory activity, in which compounds 4, 5, 7, 11, 12, 13, and 14 show significant activity.
authors: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China.
authors: Jing
authors: J
authors: Hua
authors: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China.
authors: Jin
authors: J
authors: Qi
authors: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: boyangyu59@163.com.
authors: Bo-Yang
authors: BY
authors: Yu
mesh_terms: D065089:Glycoside Hydrolase Inhibitors; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D032266:Scrophularia / Q000737:chemistry*; D000520:alpha-Glucosidases
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D057889:Iridoid Glycosides; C000595206:ningposide I; C000595207:ningposide II; C000595198:scrophuside; D000520:alpha-Glucosidases
keywords: Iridoid glycosides; Phenylpropanoid glycosides; Scrophularia ningpoensis Hemsl.; Scrophulariaceae; α-Glucosidase inhibitory activity