title: Randomised double-blind placebo-controlled study of the effect of Lactobacillus paracasei NCC 2461 on skin reactivity.
abstract: In recent decades, the prevalence of subjects with reactive skin has considerably increased in industrialised countries. 50% of women and 30% of men report cutaneous discomfort classified under reactive/sensitive skin. Several topical approaches have been proposed, in particular through improvement of galenic forms or protection of epidermal surface. We propose to act differently, deeply from inside the body via an innovative nutritional approach. To this purpose, Lactobacillus paracasei NCC 2461 (ST11) was selected because of its specific beneficial skin properties discovered in in vitro studies, i.e. diminution of neurogenic inflammation and promotion of the recovery of skin barrier function. We designed a randomised double-blind placebo-controlled clinical study with a two-month supplementation in two female treatment groups (n=32 per group). A capsaicin test was performed to monitor the time course of skin sensitivity. Moreover, transepidermal water loss was assessed to analyse the rate of skin barrier function recovery; dryness of the leg and roughness of the cheeks was investigated by a dermatologist as well as by self-assessment. The results of the present clinical trial show that oral supplementation with the probiotic decreases skin sensitivity and increases the rate of barrier function recovery. Thus, the data provide evidence that daily intake of ST11 could improve reactive skin condition.
authors: L'Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France.
authors: A
authors: A
authors: Gueniche
authors: Nestle Research Center, Vers chez les Blancs, P.O. Box 44, 1000 Lausanne 26, Switzerland.
authors: D
authors: D
authors: Philippe
authors: L'Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France.
authors: P
authors: P
authors: Bastien
authors: Nestle Research Center, Vers chez les Blancs, P.O. Box 44, 1000 Lausanne 26, Switzerland.
authors: G
authors: G
authors: Reuteler
authors: Nestle Research Center, Vers chez les Blancs, P.O. Box 44, 1000 Lausanne 26, Switzerland.
authors: S
authors: S
authors: Blum
authors: L'Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France.
authors: I
authors: I
authors: Castiel-Higounenc
authors: L'Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France.
authors: L
authors: L
authors: Breton
authors: Nestle Research Center, Vers chez les Blancs, P.O. Box 44, 1000 Lausanne 26, Switzerland.
authors: J
authors: J
authors: Benyacoub
mesh_terms: D000284:Administration, Oral; D002211:Capsaicin / Q000633:toxicity; D003681:Dehydration / Q000517:prevention & control; D003872:Dermatitis / Q000517:prevention & control; D004311:Double-Blind Method; D006801:Humans; D007778:Lactobacillus / Q000254:growth & development*; D010919:Placebos / Q000008:administration & dosage; D019936:Probiotics / Q000008:administration & dosage*; D012871:Skin Diseases / Q000517:prevention & control*; D012879:Skin Physiological Phenomena; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D002211:Capsaicin
keywords: Lactobacillus paracasei; barrier function; probiotic; reactive skin