title: [Anti-sTn antibody 3P9 and B72.3 in serological diagnosis of endometrial carcinoma].
abstract: OBJECTIVE
  To investigate the relationship between tumor-associated carbohydrate antigen sTn and endometrial carcinoma, and to evaluate the diagnostic value of 2 test methods.
  
  
  METHODS
  A total of 200 patients were enrolled, including 100 subjects with endometrial carcinoma, 42 healthy nonpregnant women, 15 pregnant women without complications, and 43 patients with benign gynecologic diseases. The serum sTn-antigen concentrations were determined by 2 test methods (3P9 combined with 4A6, and B72.3 combined with CC49).
  
  
  RESULTS
  There was a significant difference in the value and the positive rate of sTn in the serum between the subjects and the contrasts (P<0.05). The sTn level in the pregnant women was high. The sTn level in the serum and its positive rate in endometrial carcinoma became higher with the clinical stage. 3P9 combined with 4A6 was better than B72.3 combined with CC49 in the detection of sTn in the serum as to sensitivity, specificity, positive-prediction, negative-prediction, and accuracy.
  
  
  CONCLUSIONS
  The sTn antigen may become a new serological marker for the diagnosis of endometrial carcinoma, but pregnant women should be excluded. 3P9 combined with 4A6 is better than B72.3 combined with CC49 in the detection of sTn in the serum.
authors: Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
authors: Qi
authors: Q
authors: Guo
authors: Xiuqin
authors: X
authors: Chen
authors: Haibin
authors: H
authors: Sun
authors: Jianhong
authors: J
authors: Fu
authors: Shangyun
authors: S
authors: Guo
authors: Xuhua
authors: X
authors: Zhai
authors: Xiaohui
authors: X
authors: Yang
authors: Fang
authors: F
authors: Meng
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans
chemical_list: D000912:Antibodies, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; C091202:B72.3 antibody; D014408:Biomarkers, Tumor; C055491:sialosyl-Tn antigen