title: Autophagy-mediated tumor promotion.
abstract: Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
authors: Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
authors: Jessie Yanxiang
authors: JY
authors: Guo
authors: Bing
authors: B
authors: Xia
authors: Eileen
authors: E
authors: White
mesh_terms: D000818:Animals; D001343:Autophagy; D063646:Carcinogenesis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D018631:ras Proteins / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D018631:ras Proteins