title: Ivy water extracts as gastric ulcer preventive agents.
abstract: In folk medicine the ivies (Hedera L. Fam.Araliaceae) are known as plants possessing diverse curative properties. A comparative phytochemical study of the biologically active water extracts of H. colchica and H. helix and evaluation of their ulcer preventive efficacy in ethanol-induced ulcer model in rats was carried out. Water extracts of H. colchica and H. helix (300 mg/kg, i.p.) significantly (p<0.01) decrease the ulcer index (0.50 and 1.38 vs 3.17 in control) and rise macroscopic curative ratio (84.2% and 56.6%, respectively). The results clearly indicate that pretreatment with water extract of H. colchica is preferable and further experiments are required to isolate the active principals responsible for itsantiulcerogenic activity.
authors: Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Georgia; University of Quebec, Chicoutimi, Canada.
authors: K
authors: K
authors: Mulkijanyan
authors: Zh
authors: Zh
authors: Novikova
authors: M
authors: M
authors: Sulakvelidze
authors: M
authors: M
authors: Getia
authors: V
authors: V
authors: Mshvildadze
authors: G
authors: G
authors: Dekanosidze
mesh_terms: D000818:Animals; D000431:Ethanol / Q000633:toxicity; D035981:Hedera / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014867:Water / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014867:Water; D000431:Ethanol