title: Asymmetric conjugate addition to α-substituted enones/enolate trapping.
abstract: An NHC-Cu complex catalyzed the asymmetric conjugate addition (ACA) of various Grignard reagents to nonactivated α-substituted cyclic enones to give 2,3-dialkylated cyclopentanones and cyclohexanones. The Michael addition features the formation of a magnesium enolate intermediate. One-pot diastereoselective trapping of this enolate by alkyl, propargyl, allyl, and benzyl halides led to ketones with contiguous α-quaternary and β-tertiary centers.
authors: Department of Organic Chemistry, University of Geneva , Quai Ernest Ansermet, 30, 1211 Geneva 4, Switzerland.
authors: Nicolas
authors: N
authors: Germain
authors: Laure
authors: L
authors: Guénée
authors: Marc
authors: M
authors: Mauduit
authors: Alexandre
authors: A
authors: Alexakis