title: Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity.
abstract: OBJECTIVE
  To investigate the relationship between health-related quality of life (HRQoL) and different cutoff value of low level of high-density lipoprotein cholesterol (HDL-C) in Taiwanese women with different definition of obesity.
  
  
  METHODS
  Prospective observational study in women with central obesity was conducted in Taipei City Hospital. A total of 572 women were screened at our clinic, and 227 of them with a body mass index ≧27 kg/m2 defined by the Department of Health in Taiwan and weight circumference ≧80 cm were eligible for the study. We defined two groups as group A-low HDL (HDL-C < 40 mg/dL) and group B-high HDL (HDL-C < 50 mg/dL) according to different definition of hypoalphalipoproteinemia in obese women.
  
  
  RESULTS
  Significantly reduced HRQoL score was noted in group A-low HDL compared to group A-high HDL (HDL-C ≧ 40 mg/dL), but not between group B-low HDL and group B-high HDL (HDL-C ≧ 50 mg/dL). Positively correlation was noted between HDL-C level and physical domain of HRQoL score. HDL-C contributes independently to physical domain of HRQoL score after controlling for other factors. Decreased leptin and adiponectin level were noted in hypoalphalipoproteinemia groups.
  
  
  CONCLUSIONS
  Taiwanese obese women with hypoalphalipoproteinemia have adverse impact on HRQoL, especially when the HDL-C level is lower than 40 mg/dL. Both hypoalphalipoproteinemia and hypertension accounted for a great variance to lower scores of physical domain of HRQoL with positively correlation with HDL-C level observed. Decreased leptin and adiponectin were also observed in hypoalphalipoproteinemia group, which implied increased cardiovascular risk. HDL-C level may deem as another indicator for HRQoL in women with central obesity.
authors: Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
authors: I-Ju
authors: IJ
authors: Chen
authors: Wei-Chun
authors: WC
authors: Lin
authors: Chia-Yu
authors: CY
authors: Liu
authors: You-Lung
authors: YL
authors: Song
authors: Jung-Peng
authors: JP
authors: Chiu
authors: Chung-Hua
authors: CH
authors: Hsu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D052456:Hypoalphalipoproteinemias / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood / Q000150:complications / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D013624:Taiwan
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL