title: Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma?
abstract: OBJECTIVE
  An impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified albumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).
  
  
  METHODS
  Forty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy people (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated.
  
  
  RESULTS
  Serum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32).
  
  
  CONCLUSIONS
  In this study, the oxidative/antioxidant status was impaired in favor of oxidative stress in CRC patients. This observation was not confirmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers.
authors: Central Laboratories, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors: Hamit Yasar
authors: HY
authors: Ellidag
authors: Nurullah
authors: N
authors: Bulbuller
authors: Esin
authors: E
authors: Eren
authors: Sedat
authors: S
authors: Abusoglu
authors: Evren
authors: E
authors: Akgol
authors: Mustafa
authors: M
authors: Cetiner
authors: Necat
authors: N
authors: Yılmaz
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism; D000075462:Serum Albumin, Human
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014408:Biomarkers, Tumor; D016877:Oxidants; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Colorectal neoplasms; Ischemia-modified albumin; Oxidative stress