title: Muscle-specific kinase antibody associated myasthenia gravis after bone marrow transplantation.
abstract: Myasthenia gravis is a rare complication of bone marrow transplantation and graft versus host disease. We report a 30-year-old woman presented with oculobulbar and proximal limb weakness after allogeneic bone marrow transplantation for chronic myelogenous leukemia. Also, she developed graft versus host disease following bone marrow transplantation. Investigations led to the diagnosis of muscle specific kinase antibody related myasthenia gravis. There have been only two case reports of muscle specific kinase antibody positive myasthenia gravis after bone marrow transplantation in the literature, but none of the previously reported cases had graft versus host disease.
authors: Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Zeinab
authors: Z
authors: Heidarzadeh
authors: Hematology, Oncology & Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Seyyed-Asadollah
authors: SA
authors: Mousavi
authors: Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Vahid Reza
authors: VR
authors: Ostovan
authors: Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: nafisi@sina.tums.ac.ir.
authors: Shahriar
authors: S
authors: Nafissi
mesh_terms: D000328:Adult; D000906:Antibodies / Q000378:metabolism*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D009157:Myasthenia Gravis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases
keywords: Allogeneic bone marrow transplant; Graft-versus-Host Disease; Muscle-specific kinase antibody; Myasthenia gravis