title: Superselective intracerebral catheterization for administration of oncolytic virotherapy in a case of diffuse intrinsic pontine glioma.
abstract: New therapies are needed to improve current results in diffuse intrinsic pontine glioma. We present here the initial experience of administering Celyvir, autologous mesenchymal stem cells infected with ICOVIR-5, an oncolytic adenovirus that selectively replicates in cancer cells, by means of superselective intra-arterial delivery, in a patient diagnosed of diffuse intrinsic pontine glioma. Feasibility, safety, and morbidity rates of the superselective catheterization technique are comparable with those of diagnostic angiography. The intra-arterial approach warrants a greater contact of the mesenchymal stem cells with the tumor mass, and minimizes hemorrhages or vascular disruption. The tolerance to the 2 administrations was excellent, with no acute or delayed adverse effect, underscoring the feasibility of this technique for the delivery of virotherapies and/or cellular therapies in this location.
authors: Departments of *Oncohematology ‡Radiology, Hospital Universitario Niño Jesús †Department of Endovascular Therapies, Clínica Nuestra Señora del Rosario, Madrid, Spain.
authors: Fernando
authors: F
authors: Carceller
authors: Aitziber
authors: A
authors: Aleu
authors: Alfredo
authors: A
authors: Casasco
authors: Leopoldo
authors: L
authors: Guimaraens
authors: Migel A
authors: MA
authors: López-Pino
authors: Luís
authors: L
authors: Madero
authors: Manuel
authors: M
authors: Ramírez
mesh_terms: D020295:Brain Stem Neoplasms / Q000473:pathology / Q000628:therapy*; D002404:Catheterization / Q000379:methods*; D002648:Child; D017809:Fatal Outcome; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D050130:Oncolytic Virotherapy / Q000379:methods*