title: Asynchronicity of facial blood perfusion in migraine.
abstract: Asymmetrical changes in blood perfusion and asynchronous blood supply to head tissues likely contribute to migraine pathophysiology. Imaging was widely used in order to understand hemodynamic variations in migraine. However, mapping of blood pulsations in the face of migraineurs has not been performed so far. We used the Blood Pulsation Imaging (BPI) technique, which was recently developed in our group, to establish whether 2D-imaging of blood pulsations parameters can reveal new biomarkers of migraine. BPI characteristics were measured in migraineurs during the attack-free interval and compared to healthy subjects with and without a family history of migraine. We found a novel phenomenon of transverse waves of facial blood perfusion in migraineurs in contrast to healthy subjects who showed synchronous blood delivery to both sides of the face. Moreover, the amplitude of blood pulsations was symmetrically distributed over the face of healthy subjects, but asymmetrically in migraineurs and subjects with a family history of migraine. In the migraine patients we found a remarkable correlation between the side of unilateral headache and the direction of the blood perfusion wave. Our data suggest that migraine is associated with lateralization of blood perfusion and asynchronous blood pulsations in the facial area, which could be due to essential dysfunction of the autonomic vascular control in the face. These findings may further enhance our understanding of migraine pathophysiology and suggest new easily available biomarkers of this pathology.
authors: Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland ; Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
authors: Nina
authors: N
authors: Zaproudina
authors: Victor
authors: V
authors: Teplov
authors: Ervin
authors: E
authors: Nippolainen
authors: Jukka A
authors: JA
authors: Lipponen
authors: Alexei A
authors: AA
authors: Kamshilin
authors: Matti
authors: M
authors: Närhi
authors: Pasi A
authors: PA
authors: Karjalainen
authors: Rashid
authors: R
authors: Giniatullin
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000098:blood supply / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D005145:Face / Q000002:abnormalities / Q000098:blood supply* / Q000294:innervation; D005146:Facial Asymmetry / Q000473:pathology*; D005260:Female; D006261:Headache / Q000175:diagnosis* / Q000473:pathology; D006339:Heart Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007259:Infrared Rays; D008543:Melanins / Q000032:analysis; D008881:Migraine Disorders / Q000175:diagnosis* / Q000473:pathology; D011673:Pulsatile Flow; D014741:Video Recording
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D008543:Melanins