title: Prone position during ECMO is safe and improves oxygenation.
abstract: OBJECTIVE
  Combination of prone positioning (PrP) and extracorporeal membrane oxygenation (ECMO) might be beneficial in severe acute respiratory distress syndrome (ARDS), because both approaches are recommended. However, PrP during ECMO might be associated with complications such as dislocation of ECMO cannulae. We investigated complications and change of oxygenation effects of PrP during ECMO to identify "responders" and discuss our results considering different definitions of response in the literature.
  
  
  METHODS
  Retrospective analysis of complications, gas exchange, and invasiveness of mechanical ventilation during first and second PrP on ECMO at specified time points (before, during, and after PrP). We used multivariate nonparametric analysis of longitudinal data (MANOVA) to compare changes of mechanical ventilation and hemodynamics associated with the first and second procedures.
  
  
  RESULTS
  In 12 ECMO patients, 74 PrPs were performed (median ECMO duration: 10 days (IQR: 6.3- 15.5 days)). No dislocations of intravascular catheters/cannulae, endotracheal tubes or chest tubes were observed. Two PrPs had to be interrupted (endotracheal tube obstruction, acute pulmonary embolism). PaO2/FiO2-ratio increased associated with the first and second PrP (p = 0.002) and lasted after PrP in 58% of these turning procedures ("responders") without changes in ECMO blood flow, respiratory pressures, minute ventilation, portion of spontaneously triggered breathing, and compliance. Hemodynamics did not change with exception of increased mean pulmonary arterial pressure during PrP and decrease after PrP (p<0.001), while norepinephrine dosage decreased (p = 0.03) (MANOVA).
  
  
  CONCLUSIONS
  Prone position during ECMO is safe and improves oxygenation even after repositioning. This might ameliorate hypoxemia and reduce the harm from mechanical ventilation.
authors: Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin - Germany.
authors: Valesca
authors: V
authors: Kipping
authors: Steffen
authors: S
authors: Weber-Carstens
authors: Christian
authors: C
authors: Lojewski
authors: Paul
authors: P
authors: Feldmann
authors: Antje
authors: A
authors: Rydlewski
authors: Willehad
authors: W
authors: Boemke
authors: Claudia
authors: C
authors: Spies
authors: Marc
authors: M
authors: Kastrup
authors: Udo X
authors: UX
authors: Kaisers
authors: Klaus-D
authors: KD
authors: Wernecke
authors: Maria
authors: M
authors: Deja
mesh_terms: D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D016684:Prone Position; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome; D012189:Retrospective Studies