title: The role of the heme oxygenase system in the metabolic syndrome.
abstract: Molecular chaperones and the heat shock response play a major role in the maintenance of cellular homeostasis under various pathological conditions. In particular, their role is to regulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellarnetworks. Among variousheat shock proteins, Hsp32 also known as heme oxygenase-1 (HO-1), has demonstrated an important role in metabolic syndrome. In particular, the HO system seems to play a major role in the complex pathophysiological cascade involved in insulin resistance mechanisms, and adipocyte functions as measured by the release of important adipokynes. The aim of the present review is to point out the role of HO-1 in metabolic syndrome, and how to exploit its beneficial effects as a therapeutic strategy to prevent complicationsof andto improve insulin sensitivity.
authors: Ignazio
authors: I
authors: Barbagallo
authors: Anna
authors: A
authors: Nicolosi
authors: Giorgio
authors: G
authors: Calabrese
authors: Sabrina
authors: S
authors: David
authors: Sebastiano
authors: S
authors: Cimino
authors: Massimo
authors: M
authors: Madonia
authors: Department of Drug Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania (Italy). ignazio.barbagallo@unict.it.
authors: Francesco
authors: F
authors: Cappello
mesh_terms: D006360:Heat-Shock Proteins / Q000502:physiology; D051547:Heme Oxygenase-1 / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000201:enzymology* / Q000503:physiopathology*; D018832:Molecular Chaperones / Q000502:physiology
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D051547:Heme Oxygenase-1