title: Serum Eosinophilic Cationic Protein (ECP) in Asthmatic Malaysian Children.
abstract: Eosinophilic inflammation in the airways is important in the pathogenesis of childhood asthma. Serum eosinophilic cationic protein (ECP), a marker of eosinophil activation was measured in 20 asthmatic children and 19 non-asthmatic controls. There was no difference in the socio-demography, passive smoke exposure, urinary cotinine levels and family history of asthma between the 2 groups. The median serum ECP in asthmatic children was 27.0 mcg/L (IQ1 8.8, IQ3 59.0); which was higher than in non-asthmatic controls [5.9 mcg/L (IQ1 3.0, IQ3 11.9), p=0.002]. An elevated serum ECP level can be helpful as supportive evidence in the diagnosis of bronchial asthma in Malaysia children.
authors: University Hospital, Department of Paediatrics, 50603 Kuala Lumpur, Malaysia.
authors: P W K
authors: PW
authors: Chan
authors: H H
authors: HH
authors: Samsinah
authors: H Z
authors: HZ
authors: Arpin
authors: A M
authors: AM
authors: Mustafa
authors: J A
authors: JA
authors: de Bruyne
mesh_terms: D001249:Asthma / Q000175:diagnosis; D001798:Blood Proteins; D002648:Child; D047150:Eosinophil Cationic Protein; D047091:Eosinophil Granule Proteins; D004804:Eosinophils; D006801:Humans; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases; D047150:Eosinophil Cationic Protein