title: A study on the effect of aqueous extract of Lobelia chinensis on colon precancerous lesions in rats.
abstract: This paper studies the effects of Lobelia chinensis on colon precancerous lesions and on colonic epithelial proliferation and apoptosis in DMH-induced rats. After two weeks of feeding, 50 Wistar rats were randomly divided into five groups, namely the normal group, model group, Lobelia chinensis low-dose group, medium-dose group and high-dose group. Lobelia chinensis was made into ACF model, and administered to experimental groups for 10 consecutive weeks. Control group was given equivalent amount of normal saline. After feeding for 10 weeks, the rats in each group were sacrificed and the changes in colonic ACF number of rats in experimental groups were observed, and the inhibition rates were calculated. The results showed that among the rats fed for 24 h and 48 h, the number of apoptotic cells in colonic crypts of rats in DMH group did not differ significantly from the control group, while the difference was obvious between the control group and Lobelia chinensis treatment groups. The medium and high doses, that is, 0.45 g/kg and 1.35 g/kg can significantly inhibit ACF formation (P<0.01). The inhibition rates of low, medium and high doses were 8.12%, 59.42% and 65.44%, respectively.
authors: Department of Radiation Oncology, Jinan Military General Hospital, Jinan 250031, China.
authors: Shao-Rong
authors: SR
authors: Han
authors: Xiao-Yan
authors: XY
authors: Lv
authors: Yan-Ming
authors: YM
authors: Wang
authors: Hai
authors: H
authors: Gong
authors: Cong
authors: C
authors: Zhang
authors: An-Na
authors: AN
authors: Tong
authors: Ning
authors: N
authors: Yan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D029746:Lobelia; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts
keywords: DMH group; Lobelia chinensis; colonic epithelial