title: No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents.
abstract: Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Wasim
authors: W
authors: Khan
authors: King's College London, Institute of Psychiatry, London, UK.
authors: Vincent
authors: V
authors: Giampietro
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK.
authors: Cedric
authors: C
authors: Ginestet
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Flavio
authors: F
authors: Dell'Acqua
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: David
authors: D
authors: Bouls
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Steven
authors: S
authors: Newhouse
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Richard
authors: R
authors: Dobson
authors: Central Institute of Mental Health, Mannheim, Germany Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
authors: Tobias
authors: T
authors: Banaschewski
authors: King's College London, Institute of Psychiatry, London, UK.
authors: Gareth J
authors: GJ
authors: Barker
authors: Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
authors: Arun L W
authors: AL
authors: Bokde
authors: Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
authors: Christian
authors: C
authors: Büchel
authors: King's College London, Institute of Psychiatry, London, UK Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Patricia
authors: P
authors: Conrod
authors: Central Institute of Mental Health, Mannheim, Germany Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
authors: Herta
authors: H
authors: Flor
authors: Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
authors: Vincent
authors: V
authors: Frouin
authors: Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
authors: Hugh
authors: H
authors: Garavan
authors: School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
authors: Penny
authors: P
authors: Gowland
authors: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Anreas
authors: A
authors: Heinz
authors: Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Berlin, Germany.
authors: Bernd
authors: B
authors: Ittermann
authors: Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 "Imaging & Psychiatry", University Paris Sud, Orsay, and AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France.
authors: Hervé
authors: H
authors: Lemaître
authors: Central Institute of Mental Health, Mannheim, Germany Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
authors: Frauke
authors: F
authors: Nees
authors: Rotman Research Institute, University of Toronto, Toronto, Canada School of Psychology, University of Nottingham, Nottingham, UK Montreal Neurological Institute, McGill University, Montreal, Canada.
authors: Tomas
authors: T
authors: Paus
authors: The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors: Zdenka
authors: Z
authors: Pausova
authors: Central Institute of Mental Health, Mannheim, Germany Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
authors: Marcella
authors: M
authors: Rietschel
authors: Neuroimaging Center, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Germany.
authors: Michael N
authors: MN
authors: Smolka
authors: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Andreas
authors: A
authors: Ströhle
authors: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Jean
authors: J
authors: Gallinat
authors: Karolinska Institute, Stockholm, Sweden.
authors: Eric
authors: E
authors: Westman
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK.
authors: Gunther
authors: G
authors: Schumann
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Simon
authors: S
authors: Lovestone
authors: King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
authors: Andrew
authors: A
authors: Simmons
mesh_terms: D000293:Adolescent; D053327:Apolipoprotein E4 / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E
keywords: Apolipoprotein E; hippocampal volume; magnetic resonance imaging; young healthy adolescents