title: Cognitive outcome at 5 years in very premature children without severe early cerebral abnormalities. Relationships with EEG at 6 weeks after birth.
abstract: OBJECTIVE
  This prospective study aimed to analyze the relationship between EEG at 6 weeks after birth and cognitive outcome at the age of 5 in children born very preterm who did not present with severe neonatal cerebral abnormalities.
  
  
  METHODS
  EEGs were recorded at 6 weeks of age in infants born <29 weeks of gestation or weighing <1000 g at birth. At 5 years, study participants underwent a neurological assessment and cognitive evaluation with the Kaufman Assessment Battery for Children (K-ABC).
  
  
  RESULTS
  Fifty-eight children had an EEG at 6 weeks after birth. Fifty-one were evaluated at 5 years. Twenty-six children (51.0%) had one or more disabilities: neuromotor, sensory, behavioral, and/or cognitive. Children with EEG abnormalities had significantly more disabilities (20 of 25, 80%) than children with normal EEG (6 of 26, 23%) (P=0.0002). Thirty-five children underwent complete K-ABC assessment. Multiple linear regression analysis indicated a significant relationship between the overall EEG abnormalities (normal, dysmature, and/or disorganized) and two scales: mental processing composite (MPC) scales (P=0.0121), and sequential processing scales (P=0.0012). Dysmature EEGs were more predictive of lower MPC and sequential processing scales than disorganized EEGs. Immature occipital slow waves (i.e., too high for conceptional age) were consistently recorded in children with dysmature EEGs and associated with the lowest K-ABC scores.
  
  
  CONCLUSIONS
  EEG abnormalities recorded at 6 weeks after birth, such as immature occipital slow waves, were associated with later cognitive impairments. EEG at 6 weeks can be an early and reliable tool for assessing the risk of future cognitive impairment.
authors: Service de néonatologie, Maternité Régionale Universitaire, 10, rue du Docteur-Heydenreich, 54042 Nancy, France. Electronic address: d.selton@maternite.chu-nancy.fr.
authors: D
authors: D
authors: Selton
authors: M
authors: M
authors: Andre
authors: C
authors: C
authors: Debruille
authors: H
authors: H
authors: Deforge
authors: J-M
authors: JM
authors: Hascoët
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests; D011247:Pregnancy; D047928:Premature Birth / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies
keywords: Anomalies EEG au stade chronique; Chronic-stage EEG abnormalities; Cognitive disabilities; Disorganized EEG patterns; Dysmature EEG patterns; EEG dysmature; EEG désorganisé; Prognosis; Pronostic; Séquelles cognitives; Très grand prématuré; Very premature neonate