title: Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies.
abstract: Epidemiological studies have reported conflicting results between folate intake and bladder cancer risk. We conducted a meta-analysis of epidemiological studies published between 1996 and June 2013 on the relationship between folate intake and bladder cancer. We quantified associations with bladder cancer using meta-analysis of risk estimates (REs) associated to the highest versus the lowest category of folate intake using random effect models. Seven cohort and six case-control studies were eligible for inclusion. A significantly decreased risk with bladder cancer was observed in overall folate intake group (RE = 0.84; 95% CI, 0.72-0.96) and subgroup of case-control studies (RE = 0.73; 95% CI, 0.57-0.89), but not in cohort studies (RE = 0.96; 95% CI, 0.81-1.10) when comparing the highest with the lowest category of folate intake. No heterogeneity and publication bias were observed across studies. Although the current evidence, mainly based on data from case-control studies, supports an inverse association between folate intake and bladder cancer, additional large and well-designed cohort studies are needed before definitive conclusions can be drawn.
authors: Department of Urology, Hangzhou First People's Hospital, Affiliated Hangzhou Hospital of Nanjing Medical University , Hangzhou, Zhejiang , China.
authors: Huadong
authors: H
authors: He
authors: Bing
authors: B
authors: Shui
mesh_terms: D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000517:prevention & control*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid