title: Comparative study of changes in energy metabolism in rat cardiomyocytes in postinfarction cardiosclerosis and diabetes mellitus.
abstract: Cardiomyocyte energy metabolism in experimental unfolding postinfarction cardiosclerosis and diabetes mellitus was studied. Postinfarction cardiosclerosis formed 6 weeks after coronary artery occlusion. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (60 mg/kg). The rate of oxygen consumption in postinfarction cardiosclerosis and diabetes increased by 3.4 and 4.2 times, respectively. Stimulation of mitochondrial respiration (ATP, palmitic acid) significantly increased oxygen consumption in animals with postinfarction cardiosclerosis and significantly reduced this process in diabetes. The content of LDH and SDH in the myocardium of animals with diabetes and postinfarction cardiosclerosis was significantly below the control. Hence, the development of postinfarction cardiosclerosis and diabetes mellitus were characterized by reduced generation of ATP in anaerobic and aerobic pathways and oxidative phosphorylation in cardiomyocytes.
authors: Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia. dina@cardiol.tsu.ru.
authors: S A
authors: SA
authors: Afanas'ev
authors: D S
authors: DS
authors: Kondrat'eva
authors: M V
authors: MV
authors: Egorova
authors: S V
authors: SV
authors: Popov
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D019069:Cell Respiration / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004734:Energy Metabolism; D042844:L-Lactate Dehydrogenase (Cytochrome) / Q000096:biosynthesis; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012598:Sclerosis; D013385:Succinate Dehydrogenase / Q000096:biosynthesis
chemical_list: D000255:Adenosine Triphosphate; D042844:L-Lactate Dehydrogenase (Cytochrome); D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase