title: ALPPS for patients with colorectal liver metastases: effective liver hypertrophy, but early tumor recurrence.
abstract: BACKGROUND
  Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a promising method to increase resectability rates of liver tumors. Little has been published about oncological results so far. This report describes clinical evidence regarding a possible effect of ALPPS on tumor recurrence.
  
  
  METHODS
  Ten ALPPS procedures were performed for otherwise non-resectable colorectal liver metastases. Seven of these ten patients had a follow-up of at least 3 months and were analyzed for tumor recurrence.
  
  
  RESULTS
  Six of these seven patients had tumor recurrence to the liver. Three of seven patients presented with lung metastases, occurring earlier than liver metastases in two of three cases. One patient with a follow-up of 3 months had no visible recurrent disease, but increasing carcinoembryonic antigen levels.
  
  
  CONCLUSIONS
  The patient group operable only through ALPPS is at high risk for recurrence and early tumor progression. Still, this new method is the only chance for an oncological treatment strategy including a surgical approach and possibly better outcome.
authors: Division of General and Abdominal Surgery, Department of Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany, k.oldhafer@asklepios.com.
authors: Karl J
authors: KJ
authors: Oldhafer
authors: Marcello
authors: M
authors: Donati
authors: Robert M
authors: RM
authors: Jenner
authors: Axel
authors: A
authors: Stang
authors: Gregor A
authors: GA
authors: Stavrou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008026:Ligation / Q000379:methods; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D011169:Portal Vein / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D013997:Time Factors; D016896:Treatment Outcome