title: Hodgkin lymphoma and hypothermia: case report and review of the literature.
abstract: We report the development of hypothermia in a patient with Hodgkin lymphoma which resolved with chemotherapy administration. A review of the literature revealed 16 previous reports of hypothermia in patients with Hodgkin lymphoma. Overall prognosis seems to be unfavorable. To the best of our knowledge this is the first report of hypothermia in a patient with Hodgkin lymphoma transforming from chronic lymphocytic leukemia (Richter's syndrome). A possible pathophysiology could be paraneoplastic autonomic neuropathy. Physicians should be aware that Hodgkin lymphoma can present with hypothermia and should carefully monitor newly diagnosed patients with advanced disease for this complication. Likewise, patients with Hodgkin lymphoma who develop hypothermia should be screened for signs of autonomic neuropathy.
authors: Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors: Daniel
authors: D
authors: Shepshelovich
authors: Ofer
authors: O
authors: Shpilberg
authors: Meir
authors: M
authors: Lahav
authors: Gilad
authors: G
authors: Itchaki
authors: Maxim
authors: M
authors: Yakimov
authors: Pia
authors: P
authors: Raanani
authors: Amos
authors: A
authors: Cohen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007035:Hypothermia / Q000209:etiology* / Q000517:prevention & control; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control