title: The influence of cardiopulmonary by-pass on respiratory function in patients who underwent coronary disease surgery.
abstract: OBJECTIVE
  The study is designed to show influence of cardiopulmonary by-pass (CPB) on respiratory function in patients who underwent cardiac surgery.
  
  
  METHODS
  With respect on operative technique the patients were divided into two groups consisted of 40 patients, who underwent with or without CPB. On the bases of the hemodynamic measurements and counting alveolar arterial oxygen difference (A-a)DO2, saturation of mixed venous blood (SvO2), direct intrapulmonary shunt (V/Q) and hypoxemic score (PaO2/FiO2) preoperative and postoperative respiratory function in these patients is assumed. There were one preoperative and four postoperative measurements.
  
  
  CONCLUSIONS
  Statistically significant difference is found between the examined groups between mean values of alveolar arterial oxygen difference (A-a)DO2 in three postoperative measurements (p = 0.035, p = 0.015 and p = 0.011), direct intrapulmonary shunt (V/Q) in four postoperative measurements (p = 0.037, p = 0.023, p = 0.014 and p = 0.04), saturation of mixed venous blood (SvO2) in four postoperative measurements (p = 0.01, p = 0.023, p = 0.020 and p = 0.020) and hypoxemic score (PaO2/FO2) in four postoperative measurements (p = 0.018, p = 0.028, p = 0.017 and p = 0.038). The comparative analyses of parameters of respiratory function in both groups showed increased degree of acute lung injury (ALI) in group of patients underwent CPB.
  
  
  CONCLUSIONS
  Early discovering parameters of acute lung injury in early postoperative period in patients underwent cardiac surgery with cardiopulmonary by-pass can prevent development of postoperative complications and duration of hospitalization. Key words:
authors: Clinic for Cardiovascular Disease, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina. alisa@bih.net.ba
authors: Alisa
authors: A
authors: Krdzalic
authors: Department of Cardiovascular Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
authors: Tomislav
authors: T
authors: Klokocovnik
authors: Department of Thoracic Surgery, Surgery Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
authors: Goran
authors: G
authors: Krdzalic
authors: Department of General Surgery, Cantonal Hospital Bihac, Bihac, Bosnia and Herzegovina.
authors: Suad
authors: S
authors: Gaco
mesh_terms: D055371:Acute Lung Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D000328:Adult; D001784:Blood Gas Analysis / Q000379:methods; D017522:Bosnia and Herzegovina; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods; D003327:Coronary Disease / Q000601:surgery*; D042241:Early Diagnosis; D061345:Early Medical Intervention; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011182:Postoperative Care / Q000379:methods / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D012119:Respiration; D012137:Respiratory System / Q000503:physiopathology; D012189:Retrospective Studies