title: [The correlation study of HBV serological index in neonate's venus, cord blood and mother's venus blood].
abstract: OBJECTIVE
  In this study, we discussed the consistency and correlation of HBV serological indexes between neonates' venous blood and cord blood whose mothers had chronical HBV infection, as well as the correlation of thoses indexes with the mothers'.
  
  
  METHODS
  Chronically HBV infected mothers who were postive of both HBsAg and HBeAg and also had a HBV DNA virus load above 10(5) copies/ ml and their infants were enrolled. The mothers' venous blood were collected before delivery. The neonates' cord blood were collected at birth after removal of contaminants and disinfected with alcohol on the cord's surface, and the venous blood were collected before hepatitis B virus immune globin(HBIG) and hepatitis B vaccine were given. The levels of HBsAg, anti-HBs, HBeAg and anti-HBeAg were tested with Abbott microparticle chemiluminescence method (Abbott Laboratories, Abbott Architac i2000). HBV DNA quantification were tested by COBAS TagMan real-time PCR Assay.
  
  
  RESULTS
  383 mothers and their infants were enrolled. The positive rates of HBsAg in cord blood and venous blood were 61.2% and 63.9%. The positive rates of HBeAg level in cord blood and venous blood were 83.2% and 83.5%. The positive rates of HBV DNA level in cord blood and venous blood were 56.0% and 59.4%. The state of HBsAg, HBeAg and HBV DNA in cord blood and venous blood were consistency, and significant correlation was observed in their levels with correlation coefficients of 0.766, 0.857, and 0.692, respectively (P < 0.000). Significant correlation of the HBeAg levels were observed between mothers' venous blood and neonates' venous blood, as well as neonates' cord blood with correlation coefficients of 0.362 and 0.352 (P < 0.000). However, there was no significant correlation of HBsAg levels between them (r = 0.023, P = 0.785; r = 0.04, P = 0.604).
  
  
  CONCLUSIONS
  The HBV serological index of neonate's cord blood could reflect the HBV serological indexes in venous blood because of the good correlation and consistency between them.
authors: Beijing Ditan Hospital, Capital Medical University, China.
authors: Wei
authors: W
authors: Yi
authors: Lu-Xue
authors: LX
authors: Zhang
authors: Yu-Hong
authors: YH
authors: Hu
authors: Ming-Hui
authors: MH
authors: Li
authors: Hong-Xiao
authors: HX
authors: Hao
authors: Shi-Jun
authors: SJ
authors: Wang
authors: Xiu-Juan
authors: XJ
authors: Jiang
authors: Shu-Feng
authors: SF
authors: Zhang
authors: Shu-Jing
authors: SJ
authors: Song
authors: Yao
authors: Y
authors: Xie
authors: Xiao-Feng
authors: XF
authors: Liang
mesh_terms: D004279:DNA, Viral / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D014680:Veins
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens