title: Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease.
abstract: Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases.
authors: The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospital & Medical School, London, UK.
authors: A R
authors: AR
authors: Hall
authors: N
authors: N
authors: Burke
authors: R K
authors: RK
authors: Dongworth
authors: D J
authors: DJ
authors: Hausenloy
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D016923:Cell Death / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D063154:Mitochondrial Dynamics / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D009206:Myocardium / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins
keywords: Drp1; MFN1; MFN2; OPA1; mitochondrial dynamics; mitochondrial fission; mitochondrial fusion; mitochondrial morphology