title: Unilateral optic disk edema with central retinal artery and vein occlusions as the presenting signs of relapse in acute lymphoblastic leukemia.
abstract: METHODS
  A 39-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia (LAL Ph+) developed progressive vision loss to no light perception in his right eye. He had optic disk edema and later developed central artery and vein occlusions. Pan-photocoagulation, as well as radiotherapy of the whole brain were performed in several fractions. Unfortunately the patient died of hematological relapse 4 months later.
  
  
  CONCLUSIONS
  Optic nerve infiltration may appear as an isolated sign of a leukemia relapse, even before a hematological relapse occurs. Leukemic optic neuropathy is a critical sign, not only for vision, but also for life, and radiotherapy should be immediately performed before irreversible optic nerve damage occurs.
authors: Servicio de Oftalmología, Hospital Comarcal Jarrio, Coaña, Asturias, España. Electronic address: raquelsalazarmendez@gmail.com.
authors: R
authors: R
authors: Salazar Méndez
authors: Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors: M
authors: M
authors: Fonollá Gil
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D016371:Cranial Irradiation; D017809:Fatal Outcome; D006801:Humans; D017254:Leukemic Infiltration / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D008028:Light Coagulation; D008297:Male; D010211:Papilledema / Q000209:etiology* / Q000532:radiotherapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D015356:Retinal Artery Occlusion / Q000209:etiology*; D012169:Retinal Vein / Q000473:pathology*
keywords: Acute lymphoblastic leukemia; Central retinal artery occlusion; Central retinal vein occlusion; Leucemia linfoblástica aguda; Nervio óptico; Obstrucción arteria central retina; Obstrucción vena central retina; Optic nerve; Radioterapia; Radiotherapy