title: Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study.
abstract: BACKGROUND
  Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections.
  
  
  METHODS
  A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix(®))-PDT was used without success.
  
  
  METHODS
  An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL.
  
  
  CONCLUSIONS
  PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.
authors: 1 Unit of Dermatology, Hospital San Jorge , Huesca, Spain .
authors: Yolanda
authors: Y
authors: Gilaberte
authors: Carmen
authors: C
authors: Aspiroz
authors: M Carmen
authors: MC
authors: Alejandre
authors: Elena
authors: E
authors: Andres-Ciriano
authors: Blanca
authors: B
authors: Fortuño
authors: Luis
authors: L
authors: Charlez
authors: Maria Jose
authors: MJ
authors: Revillo
authors: Michael R
authors: MR
authors: Hamblin
authors: Antonio
authors: A
authors: Rezusta
mesh_terms: D000368:Aged; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D013175:Sporothrix / Q000166:cytology / Q000528:radiation effects; D013174:Sporotrichosis / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents