title: Is Mcl-1L the new anti-apoptotic effector of B-RAFV(600E) in melanoma?
abstract: A recent report has unveiled a novel mechanism by which oncogenic BRAF signalling might trigger apoptotic resistance in melanoma by selectively affecting the expression of Bcl-2 family member Mcl-1L (Exp Dermatol 2013: 22: 767). Correlation of Mcl-1 splice variants and B-RAF mutational status was determined in a panel of melanoma cell lines. In vivo validation of this mechanism, which is supported by recent literature, might provide novel therapeutic approaches such as the use of targeted Mcl-1 inhibitors to improve outcome in melanoma.
authors.affiliation: Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK.
authors.forename: Daniele
authors.initials: D
authors.lastname: Bergamaschi
keywords: B-RAF; Mcl-1; apoptosis; melanoma