title: Non-replicatingToxoplasma gondiireverses tumor-associated immunosuppression.
abstract: We examined the efficacy of using attenuated non-replicatingToxoplasma gondiiuracil auxotrophs that can be safely delivered as anticancer immunotherapeutics. This strategy exerted remarkable therapeutic activity in murine models of melanoma and ovarian carcinoma, and holds broad potential for the development of novel, highly effective anticancer vaccines.
authors.affiliation: Department of Microbiology and Immunology; Geisel School of Medicine at Dartmouth; Lebanon, NH USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Fox
authors.affiliation: Department of Microbiology and Immunology; Geisel School of Medicine at Dartmouth; Lebanon, NH USA.
authors.forename: Kiah L
authors.initials: KL
authors.lastname: Sanders
authors.affiliation: Department of Microbiology and Immunology; Geisel School of Medicine at Dartmouth; Lebanon, NH USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Bzik
keywords: CD8+ T cells; anticancer vaccines; cancer immunotherapy; non-replicating Toxoplasma gondii; reversing tumor-derived immunosuppression