title: High--valent technetium chemistry-new opportunities for radiopharmaceutical developments.
abstract: The rich coordination chemistry of (99m) Tc distinguishes this radiometal from other radiolabels applied for single-photon emission computed tomography (SPECT) or positron emission tomography (PET). This potential should be used to create novel opportunities for the development of effective imaging probes. In this context, the field of high-valent technetium chemistry has received much interest. It has been shown that fac-{(99m) TcO3 }(+) complexes are potential new synthons for radiopharmaceutical developments, due to their unique physicochemical properties and unprecedented reactivity. In this article, recent developments and the 'state of the art' in this field of technetium chemistry will be reviewed comprehensively.
authors.affiliation: Institute of Inorganic Chemistry, University of Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland.
authors.forename: Henrik
authors.initials: H
authors.lastname: Braband
mesh_terms: D055808:Drug Discovery / Q000379:methods*; D011854:Radiochemistry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium
keywords: (3 + 2)-cycloaddition; alkenes; bifunctionalization; cis-dihydroxylation reaction; coordination chemistry; labeling; radiopharmacy; technetium