title: The ACTN3 R577X polymorphism is associated with muscle power in male Japanese athletes.
abstract: In this study, we investigated whether the ACTN3 R577X polymorphism is associated with muscular power in Japanese collegiate athletes by analyzing the mean and peak power results of a 30-second Wingate anaerobic test (WAnT) with respect to the ACTN3 R577X genotype in 253 Japanese athletes (144 men and 109 women). Each athlete performed a 30-second WAnT with a resistance equal to 7.5% of his or her body weight. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. The ACTN3 R577X genotypes exhibited a Hardy-Weinberg equilibrium distribution in our population. The relative and absolute mean power results of the 30-second WAnT did not differ significantly among the genotypes. However, the relative peak power result of the WAnT was significantly higher in the R-allele-dominant model groups than in the XX group in male but not female athletes. These results suggest that the ACTN3 R allele is associated with the relative peak power during the WAnT in male Japanese collegiate athletes.
authors.affiliation: 1Sports Training Center, Nippon Sport Science University, Tokyo, Japan; 2Laboratory of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan; 3Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan; and 4Laboratory of Sports Nutrition, Nippon Sport Science University, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kikuchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakazato
authors.forename: Seok-ki
authors.initials: SK
authors.lastname: Min
authors.forename: Dai
authors.initials: D
authors.lastname: Ueda
authors.forename: Shoji
authors.initials: S
authors.lastname: Igawa
mesh_terms: D000185:Actinin / Q000235:genetics*; D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D054874:Athletic Performance / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D053580:Muscle Strength / Q000235:genetics*; D018482:Muscle, Skeletal / Q000502:physiology*; D011110:Polymorphism, Genetic; D012737:Sex Factors; D055815:Young Adult
chemical_list: C118456:ACTN3 protein, human; D000185:Actinin