title: Effect of fat free mass on serum and plasma BDNF concentrations during exercise and recovery in healthy young men.
abstract: Exercise results in release of brain derived neurotrophic factor into the circulation; however, little is known about the changes in serum and plasma brain derived neurotrophic factor concentrations and factors influencing brain derived neurotrophic factor during exercise and recovery. Serum (n=23) and plasma (n=10) brain derived neurotrophic factor concentrations were measured in healthy young men at rest, during steady-rate and after exercise to determine the maximum aerobic power. A two-way analysis of variance was used to investigate brain derived neurotrophic factor levels in blood during exercise and recovery, with one between-subject factor (a median split on: age, height, body mass, fat free mass, body mass index and aerobic fitness), and one within-subject factor (time). Serum brain derived neurotrophic factor concentrations increased in response to exercise and declined rapidly in recovery. Plasma brain derived neurotrophic factor had a greater proportional increase relative to exhaustive exercise compared with serum brain derived neurotrophic factor and was slower to return to near baseline values. There was a significant group-by-time interaction indicating a greater release and faster recovery for serum brain derived neurotrophic factor in high- compared with low-fat free mass individuals.
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Gilder
authors.affiliation: Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom. Electronic address: rramsbottom@brookes.ac.uk.
authors.forename: R
authors.initials: R
authors.lastname: Ramsbottom
authors.affiliation: Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Currie
authors.affiliation: Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Sheridan
authors.affiliation: School of Sport, Performing Arts and Leisure, University of Wolverhampton, WS1 3BD, United Kingdom.
authors.forename: A M
authors.initials: AM
authors.lastname: Nevill
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000328:Adult; D001835:Body Weight; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D015444:Exercise; D006801:Humans; D008297:Male; D010807:Physical Endurance; D010949:Plasma; D012016:Reference Values; D044967:Serum
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: BDNF; Exercise; Plasma; Serum