title: Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats.
abstract: OBJECTIVE
  The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet.
  
  
  METHODS
  Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%.
  
  
  RESULTS
  The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet.
  
  
  CONCLUSIONS
  Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.
authors.forename: Thiago
authors.initials: T
authors.lastname: Bruder-Nascimento
authors.forename: Dijon Henrique Salomé
authors.initials: DH
authors.lastname: Campos
authors.forename: Carlos
authors.initials: C
authors.lastname: Alves
authors.forename: Samuel
authors.initials: S
authors.lastname: Thomaz
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Cicogna
authors.forename: Sandra
authors.initials: S
authors.lastname: Cordellini
mesh_terms: D050154:Adiposity; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D059305:Diet, High-Fat; D004435:Eating / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000097:blood; D007103:Immobilization; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009752:Nutritional Status; D009765:Obesity / Q000378:metabolism*; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D003345:Corticosterone