title: Early weight development of goats experimentally infected with Mycobacterium avium subsp. paratuberculosis.
abstract: Johne's disease is an infectious chronic inflammatory bowel disease in ruminants. The key factor for the management of this disease is an early positive diagnosis. Unfortunately, most diagnostics detect animals with Johne's disease in the clinical stage with positive serology and/or positive fecal cultures. However, for effective management of the disease within herds, it is important to detect infected animals as early as possible. This might only be possible with the help of parameters not specific for Johne's disease but that give an early indication for chronic infections such as weight development. Here we report our findings on the development of total body weight and weight gain during the first six months of goats experimentally infected to induce Johne's disease. Twenty dairy goat kids age 2 to 5 days were included in this study. Goats were divided into two groups: a negative control group and a positive infected group. The weight was obtained weekly throughout the study. Goats of the positive group were infected at the age of seven weeks. We detected significant changes in weight gain and total body weight as early as one week after infection. Differences are significant throughout the six month time period. Weight as a non-specific parameter should be used to monitor infection especially in studies on Johne's disease using the goat model. Our study suggests that goats with Johne's disease have a reduced weight gain and reduced weight when compared with healthy goats of the same age.
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Alyssa N
authors.initials: AN
authors.lastname: Malone
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Darcy M
authors.initials: DM
authors.lastname: Fletcher
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Megan B
authors.initials: MB
authors.lastname: Vogt
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Meyer
authors.affiliation: Department of Statistics, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Hess
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
authors.forename: Torsten M
authors.initials: TM
authors.lastname: Eckstein
mesh_terms: D000818:Animals; D001835:Body Weight; D015511:Goat Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006041:Goats; D016927:Mycobacterium avium subsp. paratuberculosis; D010283:Paratuberculosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors