title: Primary effects of intravitreal bevacizumab in patients with diabetic macular edema.
abstract: OBJECTIVE
  To evaluate the efficacy of primary intra vitreal bevacizumab (IVB) injection on macular edema in diabetic patients with improvement in best corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography (OCT).
  
  
  METHODS
  This prospective interventional case series study was conducted at Retina Clinic, Al-Ibrahim Eye Hospital, and Isra Postgraduate Institute of Ophthalmology Karachi. Between December 2010 to June 2012. BCVA measurement with Early Treatment in Diabetic Retinopathy Study (ETDRS) charts and ophthalmic examination, including Slit-lamp bio microscopy, indirect ophthalmoscopy, Fundus fluorescein angiography (FFA) and OCT were done at the base line examination. At monthly interval all patients were treated with 3 injections of 0.05 ml intra vitreal injection containing 1.25 mg bevacizumab. Patients were followed up for 6 months and BCVA and OCT were taken at the final visit at 6 month.
  
  
  RESULTS
  The mean BCVA at base line was 0.42±0.14 Log Mar units. This improved to 0.34±0.13, 0.25±0.12, 0.17±0.12 and 0.16±0.14 Log Mar units at 1 month after 1(st), 2(nd) 3(rd) injections and at final visit at 6 months respectively, a difference that was statistically significant (P>0.0001) from base line. The mean 1mm CMT measurement was 452.9 ± 143.1 µm at base line, improving to 279.8 ± 65.2 µm (P<0.0001) on final visit. No serious complications were observed.
  
  
  CONCLUSIONS
  Primary IVB at a dose of 1.25 mg on monthly interval seems to provide stability and improvement in BCVA and CMT in patient with DME.
authors.affiliation: Dr. Iftikhar-ul-Haq Tareen, FCPS.
authors.forename: Iftikhar-Ul-Haq
authors.initials: IU
authors.lastname: Tareen
authors.affiliation: Prof. Azizur Rahman, MCPS, FCPS.
authors.forename: Azizur
authors.initials: A
authors.lastname: Rahman
authors.affiliation: Prof. P.S Mahar, FRCS, FRCOphth.
authors.forename: P S
authors.initials: PS
authors.lastname: Mahar
authors.affiliation: Prof. Muhammad Saleh Memon, DO, FRCS.
authors.forename: Muhammad Saleh
authors.initials: MS
authors.lastname: Memon
keywords: Best Corrected Visual Acuity (BCVA); Central Macular Thickness (CMT); Diabetic Macular Edema (DME); Intra Vitreal Bevacizumab (IVB)