title: Microfluidic paper-based devices for bioanalytical applications.
abstract: Paper has become increasingly recognized as a very interesting substrate for the construction of microfluidic devices, with potential application in a variety of areas, including health diagnosis, environmental monitoring, immunoassays and food safety. The aim of this review is to present a short history of analytical systems constructed from paper, summarize the main advantages and disadvantages of fabrication techniques, exploit alternative methods of detection such as colorimetric, electrochemical, photoelectrochemical, chemiluminescence and electrochemiluminescence, as well as to take a closer look at the novel achievements in the field of bioanalysis published during the last 2 years. Finally, the future trends for production of such devices are discussed.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry - UNICAMP, P.O.Box 6154, 13084-971, Campinas, SP, Brazil.
authors.forename: Murilo
authors.initials: M
authors.lastname: Santhiago
authors.forename: Emilia W
authors.initials: EW
authors.lastname: Nery
authors.forename: Glauco P
authors.initials: GP
authors.lastname: Santos
authors.forename: Lauro T
authors.initials: LT
authors.lastname: Kubota
mesh_terms: D001419:Bacteria / Q000302:isolation & purification; D001688:Biological Products / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D003124:Colorimetry / Q000379:methods; D055664:Electrochemical Techniques; D004784:Environmental Monitoring / Q000295:instrumentation*; D059022:Food Safety / Q000379:methods; D006801:Humans; D008163:Luminescent Measurements; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000639:trends; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D010209:Paper; D010575:Pesticides / Q000032:analysis; D055668:Photochemical Processes
chemical_list: D001688:Biological Products; D015415:Biomarkers; D010575:Pesticides