title: Myristicyclins A and B: antimalarial procyanidins from Horsfieldia spicata from Papua New Guinea.
abstract: An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-μM range.
authors.affiliation: Departments of Medicinal Chemistry and ‡Pharmacology and Toxicology, College of Pharmacy and L. S. Skaggs Pharmacy Institute, University of Utah , 30 S 2000 E, Salt Lake City, Utah 84112, United States.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Lu
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Van Wagoner
authors.forename: Cristopher D
authors.initials: CD
authors.lastname: Pond
authors.forename: Ann R
authors.initials: AR
authors.lastname: Pole
authors.forename: James B
authors.initials: JB
authors.lastname: Jensen
authors.forename: D'Arbra
authors.initials: D
authors.lastname: Blankenship
authors.forename: Brian T
authors.initials: BT
authors.lastname: Grimberg
authors.forename: Robert
authors.initials: R
authors.lastname: Kiapranis
authors.forename: Teatulohi K
authors.initials: TK
authors.lastname: Matainaho
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000188:drug therapy; D015394:Molecular Structure; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D044946:Biflavonoids; D044945:Proanthocyanidins; C000589871:myristicyclin A; C000589872:myristicyclin B; C017674:procyanidin; D002392:Catechin