title: The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.
abstract: Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome during memory formation. The ubiquitin-specific protease 14 (USP14) is a proteasomal deubiquitinating enzyme that is thought to regulate protein degradation in neurons; however, it is unknown if USP14 is involved in learning-dependent synaptic plasticity. We found that infusion of a USP14 inhibitor into the amygdala impaired long-term memory for a fear conditioning task, suggesting that USP14 is a critical regulator of long-term memory formation in the amygdala.
authors.affiliation: Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Jarome
authors.forename: Janine L
authors.initials: JL
authors.lastname: Kwapis
authors.forename: Jada J
authors.initials: JJ
authors.lastname: Hallengren
authors.forename: Scott M
authors.initials: SM
authors.lastname: Wilson
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Helmstetter
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000679:Amygdala / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000633:toxicity; D005239:Fear / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D043222:Ubiquitin Thiolesterase