title: Papillary serous carcinoma of the cervix mixed with squamous cells: A report of the first case.
abstract: OBJECTIVE
  Primary papillary serous carcinoma (PPSC) of the cervix is rarely recognized, with the aggressive and unpredictable course. Here we report a case of primary adenosquamous papillary serous carcinoma of the cervix in a woman who underwent comprehensive treatment.
  
  
  METHODS
  A 53-year-old woman presented with irregular vaginal bleeding in hospital. The patient with a diagnosis of PPSC by an intracolposcopic biopsy received radical hysterectomy with bilateral salpingo-oophorectomy, right pelvic lymphadenectomy, left pelvic lymph node dissection, and postoperative concurrent chemoradiotherapy. Postoperative immunohistochemistry showed that CK5/6, CK7, P16, CEA, CA12-5 and P53 were positive. During 17 months after operation, the patient demonstrated distant metastases of lymph nodes and finally died of brain metastasis.
  
  
  CONCLUSIONS
  Papillary serous adenocarcinoma of the cervix mixed with squamous cell carcinoma has not been reported since now, and here, this is the first documented case. Despite surgery and concurrent chemoradiotherapy, which were reported as effective therapeutic strategies for papillary serous adenocarcinoma of the cervix, the patient showed a poorer prognosis. Taken together, papillary serous adenosquamous carcinoma of the cervix could be more malignant than pure papillary serous adenocarcinoma.
authors.affiliation: Department of Gynecology and Obstetrics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100 Hongshan Road, Nanjing 210028, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Gynecology and Obstetrics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100 Hongshan Road, Nanjing 210028, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100 Hongshan Road, Nanjing 210028, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Pathology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100 Hongshan Road, Nanjing 210028, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Gynecology and Obstetrics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100 Hongshan Road, Nanjing 210028, China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Wan
keywords: AC, adenocarcinoma; Adenosquamous carcinoma; CA, cancer antigen; CEA, carcinoembryonic antigen; CT, computed tomography; MRI, magnetic resonance imaging; PPSC, Primary papillary serous carcinoma; Papillary serous carcinoma of the cervix; SCC, squamous cell carcinoma; Therapy