title: Staphylococcus aureus persistence in non-professional phagocytes.
abstract: S. aureus is a frequent cause of chronic and therapy-refractory infections. The ability of S. aureus to invade different types of non-professional phagocytes, to escape from the host lysosomal degradation machinery and to persist within the intracellular location for long time periods are most likely essential steps in pathogenesis. During the course from acute to chronic infection the bacteria need to dynamically react to the environmental changes and to adapt to the intracellular environment. In this context the bacteria change to SCV-like phenotypes that exhibit some characteristics of stable SCV-mutants, like upregulation of adhesins and downregulation of toxins. The exact formation mechanism and further typical features of these dynamically forming SCVs are largely unknown. In this review, recent data on the essential steps to establish chronic infections will be summarized and the clinical consequences of the dynamic bacterial adaptation mechanisms will be discussed.
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany. Electronic address: loeffleb@uni-muenster.de.
authors.forename: Bettina
authors.initials: B
authors.lastname: Löffler
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
authors.forename: Lorena
authors.initials: L
authors.lastname: Tuchscherr
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Niemann
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Peters
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D057131:Immune Evasion; D010586:Phagocytes / Q000276:immunology* / Q000382:microbiology*; D010588:Phagosomes / Q000276:immunology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000276:immunology / Q000502:physiology*
keywords: Chronic infections; Immune escape; Intracellular bacterial persistence; Phagosomal escape; S. aureus host cell invasion