title: [Anti-sclerostin antibody : its bone formation effect and therapeutic potential for osteoporosis].
abstract: In a rare accident of nature, some families have been found to have dense and strong bones due to a recessive loss of function mutation in the SOST gene that encodes for sclerostin, a protein expressed by osteocytes that downregulates osteoblastic bone formation. Knowledge of this molecule and its actions led rather quickly to the development of anti-sclerostin antibodies that lead to marked increases in bone mass in both animals and human subjects. Blocking sclerostin action with anti-sclerostin antibodies is a promising new therapeutic approach to osteoanabolic therapy of osteoporosis.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015519:Bone Density / Q000276:immunology / Q000502:physiology*; D001842:Bone and Bones / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D010011:Osteocytes / Q000276:immunology / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000911:Antibodies, Monoclonal