title: Interstitial lung edema triggered by marathon running.
abstract: The purpose of this study was to determine whether marathon running causes lung edema, and if so, to determine its effects on runners. Posterior/anterior (PA) radiographs were taken one day before the marathon and at 19, 55, and 98min post-marathon in 26 runners. The pre and post exercise radiographs of each runner were collated, and then read simultaneously. Two physicians interpreted the images independently in a blinded fashion. The PA radiographs were viewed together at each time-point and findings suggestive for interstitial lung edema were rated as 'mild,' 'moderate,' or 'severe' based on four different radiological criteria. Forty-six percent of the runners presented radiographic findings suggestive of mild to severe interstitial lung edema. Radiographic findings persisted until 98-min post-marathon, with at least moderate degree increases found more frequently in women (55%) than men (6%) (p<0.01). In conclusion, about half of the runners developed interstitial lung edema of varying degrees post-exercise with the incidence being higher in women compared to men.
authors.affiliation: Department of Health and Sport Sciences, University of Louisville, Louisville, KY 40292, United States; Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, United States. Electronic address: gerryzavorsky@gmail.com.
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Zavorsky
authors.affiliation: Department of Radiological Sciences, University of California - Irvine, Irvine, CA 92697, United States.
authors.forename: Eric N C
authors.initials: EN
authors.lastname: Milne
authors.affiliation: Section of Respiratory Medicine, Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Lavorini
authors.affiliation: Department of Radiology, Regional Hospital of Scranton, Scranton, PA 18510, United States.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Rienzi
authors.affiliation: Human Performance Laboratory, Ball State University, Muncie, IN 47306, United States.
authors.forename: Kaleen M
authors.initials: KM
authors.lastname: Lavin
authors.affiliation: Human Physiology Laboratory, Marywood University, Scranton, PA 18509, United States.
authors.forename: Allison M
authors.initials: AM
authors.lastname: Straub
authors.affiliation: Section of Respiratory Medicine, Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Pistolesi
mesh_terms: D000328:Adult; D001265:Athletic Injuries / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000502:physiology*; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000209:etiology*; D012420:Running / Q000293:injuries*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Endurance; Exercise; Lung fluid; Pulmonary; Water