title: Insulin resistance in non-diabetic patients of chronic Hepatitis C.
abstract: OBJECTIVE
  To determine insulin resistance in non-diabetic chronic hepatitis C patients using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).
  
  
  METHODS
  Patients having anti-HCV positive were included in this study. Patients with diabetes mellitus, thyroid disease, hyperlipidemias, hypercortisolism and infective diseases other than hepatitis C were excluded. Age, weight, height and absence of diabetes were documented. Fasting blood glucose and fasting insulin levels were done. Body mass index and insulin resistance was calculated using the formulas. Patients having insulin resistance using formula HOMA-IR>2.5 were labeled as insulin resistant. Data was analyzed using SPSS-18.
  
  
  RESULTS
  One hundred and fifty five patients according to sample size estimation were enrolled, in whom HOMA-IR was calculated, the mean value was found to be 2.47 ±1.30. A total of 79 (51%) of patients had HOMA-IR more than 2.5 showing insulin resistance.
  
  
  CONCLUSIONS
  In a third world country like Pakistan, where there is a high prevalence of hepatitis C infection, the consequences of the disease are also very common. Insulin resistance was found in 51% of patients with chronic hepatitis C.
authors.affiliation: Dr. Zareen Kiran, MBBS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Zareen
authors.initials: Z
authors.lastname: Kiran
authors.affiliation: Dr. Bader Faiyaz Zuberi, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Bader Faiyaz
authors.initials: BF
authors.lastname: Zuberi
authors.affiliation: Dr. Daniah Anis, MBBS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Daniah
authors.initials: D
authors.lastname: Anis
authors.affiliation: Dr. Rashid Qadeer, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Rashid
authors.initials: R
authors.lastname: Qadeer
authors.affiliation: Dr. Khalid Hassan, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Khalid
authors.initials: K
authors.lastname: Hassan
authors.affiliation: Prof. Salahuddin Afsar, FRCP, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Salahuddin
authors.initials: S
authors.lastname: Afsar
keywords: Chronic Hepatitis C Infection; Diabetes Mellitus; HOMA-IR; Insulin Resistance