title: Use of wave intensity analysis of carotid arteries in identifying and monitoring left ventricular systolic function dynamics in rabbits.
abstract: Wave intensity analysis (WIA) of the carotid artery was conducted to determine the changes that occur in left ventricular systolic function after administration of doxorubicin in rabbits. Each randomly selected rabbit was subject to routine ultrasound, WIA of the carotid artery, cardiac catheterization and pathologic examination every week and was followed for 16 wk. The first positive peak (WI1) of the carotid artery revealed that left ventricular systolic dysfunction occurred earlier than conventional indexes of heart function. WI1 was highly, positively correlated with the maximum rate of rise in left ventricular pressure in cardiac catheterization (r = 0.94, p < 0.01) and moderately negatively correlated with the apoptosis index of myocardial cells, an indicator of myocardial damage (r = -0.69, p < 0.01). Ultrasound WIA of the carotid artery sensitively reflects early myocardial damage and cardiac function, and the result is highly consistent with cardiac catheterization findings and the apoptosis index of myocardial cells.
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhengrongqin123@163.com.
authors.forename: Rongqin
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xiaoxian
authors.initials: X
authors.lastname: Qian
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Chengxi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Baoshun
authors.initials: B
authors.lastname: Hao
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D004317:Doxorubicin; D004452:Echocardiography / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D063177:Pulse Wave Analysis / Q000379:methods*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014665:Vasodilator Agents; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D014665:Vasodilator Agents; D004317:Doxorubicin
keywords: Carotid artery; Echocardiography; Ejection fraction; Left ventricular systolic function; Wave intensity