title: Relevance of plasma obestatin and early arteriosclerosis in patients with type 2 diabetes mellitus.
abstract: We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM according to the oral glucose tolerance test (OGTT). We found that higher levels of fasting insulin (Fins), fasting blood glucose, 2 h OGTT glucose, homeostasis model assessment of insulin resistance (HOMA-IR), low density lipoprotein cholesterol, glycated haemoglobin, and C-reactive protein (CRP), as well as lower obestatin level and higher intima-media thickness level (IMT), existed in T2DM group compared with NGT group and IGT group (P < 0.01). Also, obestatin level was independently associated with HOMA-IR and CRP, while IMT level was independently associated with HOMA-IR, triglyceride, Fins, and obestatin (P < 0.01), based on stepwise multiple regression analysis. Therefore, we deduced that the low level of plasma obestatin might be related to early arteriosclerosis in patients with T2DM via increasing IMT level, and elevated plasma obestatin levels might protect T2DM patients against carotid atherosclerosis to some extent.
authors.affiliation: Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Peng-Ying
authors.initials: PY
authors.lastname: Gu
authors.affiliation: Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Kang
authors.affiliation: Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Wang
authors.affiliation: Department of Endocrine Laboratory, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Ultrasonic Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Shan-Dong
authors.initials: SD
authors.lastname: Ye
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging; D003925:Diabetic Angiopathies / Q000097:blood / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D054439:Ghrelin / Q000097:blood*; D018149:Glucose Intolerance / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D054439:Ghrelin; C505799:obestatin, human