title: A man with oral lesions, constipation and back pain.
abstract: We describe an unusual presentation of disseminated Kaposi sarcoma in a 49-year-old African-American man with AIDS who was admitted to the hospital for constipation and back pain. Magnetic resonance imagings of the thoracic and lumbar spine were grossly abnormal, however, a biopsy of the iliac crest was interpreted as normal. The patient remained a diagnostic enigma until disseminated Kaposi sarcoma was suspected, based on vascular plaque-like lesions observed on his hard palate and right conjunctiva. Slides of the bone biopsy with were stained for human herpes virus-8 (HHV-8) antigen, and were positive. AIDS-related skeletal manifestations of Kaposi sarcoma have been reported in the literature but are infrequent.
authors.affiliation: Division of Infectious Diseases, University of California San Francisco, Fresno Medical Education Program, Fresno, CA, USA amu@fresno.ucsf.edu.
authors.forename: Anandit
authors.initials: A
authors.lastname: Mu
authors.affiliation: Division of Infectious Diseases, University of California San Francisco, Fresno Medical Education Program, Fresno, CA, USA.
authors.forename: Naiel
authors.initials: N
authors.lastname: Nassar
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D001741:Black or African American; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001416:Back Pain / Q000209:etiology*; D001706:Biopsy; D003248:Constipation / Q000209:etiology*; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D059012:Lost to Follow-Up; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D013125:Spinal Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D044966:Anti-Retroviral Agents; D000903:Antibiotics, Antineoplastic; C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: HIV/AIDS; Kaposi sarcoma; human herpes virus-8