title: Effects of n-3 polyunsaturated fatty acids (PUFAs) on circulating adiponectin and leptin in subjects with type 2 diabetes mellitus.
abstract: Recent evidence suggests that omega-3 polyunsaturated fatty acids [n-3 PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], improve insulin sensitivity in humans. In a double-blind, placebo-controlled, randomized, crossover study, we investigated the effects of EPA/DHA on paraoxonase-1 activity as well as fasting and postprandial levels of circulating adiponectin and leptin in 34 subjects with type 2 diabetes mellitus who received daily for 6 weeks either 2 g purified EPA/DHA or olive oil (placebo), separated by a 6 weeks washout. At the end of each treatment, measurements were performed in fasting state and 2, 4, and 6 h following a standardized high-fat meal (600 kcal). No significant differences in fasting and postprandial circulating adiponectin, leptin, and paraoxonase-1 activity were seen between n-3 PUFAs and placebo. Our data do not support an insulin sensitizing effect of n-3 PUFAs by means of influencing circulating adipocytokines in this population. Clinical Trial Register Number: NCT00328536.
authors.affiliation: Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stirban
authors.affiliation: Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Nandrean
authors.affiliation: Institute for Laboratory and Transfusion Medicine of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Götting
authors.affiliation: Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Stratmann
authors.affiliation: Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Tschoepe
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D015525:Fatty Acids, Omega-3; D020738:Leptin