title: The effect of helicobacter pylori eradication on liver fat content in subjects with non-alcoholic Fatty liver disease: a randomized open-label clinical trial.
abstract: BACKGROUND
  The role of Helicobacter pylori (HP) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is unclear.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effect of HP eradication on liver fat content (LFC), liver function tests (LFT), lipid profile, and homeostasis model assessment-IR (HOMA-IR) index in NAFLD.
  
  
  METHODS
  Dyspeptic patients with increased serum aminotransferase levels were enrolled in the study. The exclusion criteria were factors affecting serum aminotransferase or HP treatment strategy. Participants with persistent elevated serum aminotransferase level and ultrasound criteria for identification of fatty liver were presumed to have NAFLD. "NAFLD liver fat score" was used to classify NAFLD. Those with "NAFLD liver fat score" greater than -0.64 and positive results for urea breath test (UBT), were included. Lifestyle modification was provided to all participants. HP eradication was performed in intervention arm. LFC, fasting serum glucose (FSG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), cholesterol (CHOL), high and low-density lipoprotein (HDL, LDL), and HOMA-IR were checked at baseline and after that, at intervals of eight weeks and twenty four weeks.
  
  
  RESULTS
  One hundred (49 males) patients with the mean age of 43.46 (± 11.52) were studied. Repeated measure ANOVA showed a significant reduction in LFC, anthropometric measurements, and laboratory parameters (except for HDL) in the both groups during the study; however, no significant difference was observed between the groups.
  
  
  CONCLUSIONS
  It seems that HP eradication per se might not affect LFC, LFT, lipid profile, and insulin resistance in dyspeptic NAFLD patients.
authors.affiliation: Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Raika
authors.initials: R
authors.lastname: Jamali
authors.affiliation: Internal Medicine Ward, Sina Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mofid
authors.affiliation: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Homayoon
authors.initials: H
authors.lastname: Vahedi
authors.affiliation: Internal Medicine Ward, Sina Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Rojin
authors.initials: R
authors.lastname: Farzaneh
authors.affiliation: Internal Medicine Ward, Sina Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Shahab
authors.initials: S
authors.lastname: Dowlatshahi
keywords: Alanine Transaminase; Aspartate Aminotransferases; Helicobacter Pylori; Insulin Resistance; Non-alcoholic Fatty Liver Disease