title: Paradoxical Reaction to Golimumab: Tumor Necrosis Factor α Inhibitor Inducing Psoriasis Pustulosa.
abstract: OBJECTIVE
  Golimumab is a human monoclonal antibody, used for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Adverse reactions are increasing with this class of medication (tumor necrosis factor α inhibitors).
  
  
  METHODS
  The authors present a case of a female patient who presented with psoriasis pustulosa after the use of golimumab for rheumatoid arthritis.
  
  
  CONCLUSIONS
  Paradoxically, in this case, golimumab, which is used for psoriasis, induced the pustular form of this disease. We are observing an increasing number of patients who develop collateral effects with tumor necrosis factor α inhibitors, and the understanding of the mechanism of action and how these adverse reactions occur may contribute to avoid these sometimes severe situations.
authors.affiliation: Sector of Dermatology and Post-Graduation Course - HUCFF-UFRJ and School of Medicine, Rio de Janeiro, Brazil.
authors.forename: Marien Siqueira
authors.initials: MS
authors.lastname: Soto Lopes
authors.affiliation: Sector of Dermatology and Post-Graduation Course - HUCFF-UFRJ and School of Medicine, Rio de Janeiro, Brazil.
authors.forename: Beatriz Moritz
authors.initials: BM
authors.lastname: Trope
authors.affiliation: Sector of Dermatology and Post-Graduation Course - HUCFF-UFRJ and School of Medicine, Rio de Janeiro, Brazil.
authors.forename: Maria Paula Rua
authors.initials: MP
authors.lastname: Rochedo Rodriguez
authors.affiliation: Sector of Dermatology and Post-Graduation Course - HUCFF-UFRJ and School of Medicine, Rio de Janeiro, Brazil.
authors.forename: Rachel Lima
authors.initials: RL
authors.lastname: Grynszpan
authors.affiliation: Sector of Pathology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Tullia
authors.initials: T
authors.lastname: Cuzzi
authors.affiliation: Sector of Dermatology and Post-Graduation Course - HUCFF-UFRJ and School of Medicine, Rio de Janeiro, Brazil.
authors.forename: Marcia
authors.initials: M
authors.lastname: Ramos-E-Silva
keywords: Golimumab; Paradoxical reaction; Psoriasis pustulosa; Tumor necrosis factor α inhibitor