title: Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions.
abstract: Direct repair of UV-induced DNA lesions represents an elegant method for many organisms to deal with these highly mutagenic and cytotoxic compounds. Although the participating proteins are structurally well investigated, the exact repair mechanism of the photolyase enzymes remains a vivid subject of current research. In this review, we summarize and highlight the recent contributions to this exciting field.
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Andrea Christa
authors.initials: AC
authors.lastname: Kneuttinger
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Gengo
authors.initials: G
authors.lastname: Kashiwazaki
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Prill
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Korbinian
authors.initials: K
authors.lastname: Heil
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.affiliation: Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Carell
mesh_terms: D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000633:toxicity; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism*; D015394:Molecular Structure; D009153:Mutagens / Q000633:toxicity; D011740:Pyrimidine Dimers / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D003603:Cytotoxins; D009153:Mutagens; D011740:Pyrimidine Dimers; D004255:Deoxyribodipyrimidine Photo-Lyase