title: Making sense in antisense: therapeutic potential of noncoding RNAs in diabetes-induced vascular dysfunction.
abstract: The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important features of diabetes-induced vascular disease, which include metabolic deregulation, increased oxidative stress, release of inflammatory mediators like adipokines, and pathologic changes in vascular cells, all are depicted and governed by a certain set of noncoding RNAs. While these mechanisms are being unravelled, new diagnostic and therapeutic opportunities to treat diabetes-induced vascular disease emerge.
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine (CMM L8), Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Eken
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine (CMM L8), Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine (CMM L8), Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Chernogubova
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine (CMM L8), Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Maegdefessel
mesh_terms: D000818:Animals; D003925:Diabetic Angiopathies / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D046228:Microarray Analysis; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D007328:Insulin; D016372:RNA, Antisense; D022661:RNA, Untranslated