title: Association of esophageal candidiasis and squamous cell carcinoma.
abstract: Chronic esophageal candidiasis is an infection that is mostly seen in immunocompromised conditions, among which is chronic mucocutaneous candidiasis (CMC). Recently an association between CMC and esophageal carcinoma has been reported. Here we present two patients with chronic esophageal candidiasis who developed esophageal squamous cell carcinoma and we discuss the etiologic role of Candida-induced nitrosamine production, the loss of STAT1 function and impaired tumor surveillance and T-lymphocyte function in the development of esophageal carcinoma.
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: C E
authors.initials: CE
authors.lastname: Delsing
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: C P
authors.initials: CP
authors.lastname: Bleeker-Rovers
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: F L
authors.initials: FL
authors.lastname: van de Veerdonk
authors.affiliation: Department of medical oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Tol
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: J W M
authors.initials: JW
authors.lastname: van der Meer
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Kullberg
authors.affiliation: Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: M G
authors.initials: MG
authors.lastname: Netea
keywords: Chronic mucocutaneous candidiasis; Esophageal cancer; Esophageal candidiasis