title: Comparative study of intravenous iron versus intravenous ascorbic Acid for treatment of functional iron deficiency in patients under hemodialysis: a randomized clinical trial.
abstract: BACKGROUND
  Functional iron deficiency (FID) may cause erythropoietin resistance in patients under hemodialysis (HD). Since the role of chronic inflammation or oxidative stress in its pathogenesis is unclear, controversy remains to whether intravenous iron or intravenous ascorbic acid (an antioxidant) can improve this anemia due to decreased iron availability.
  
  
  OBJECTIVE
  The current study compared the effect of intravenous iron versus intravenous ascorbic acid in the management of FID in HD patients.
  
  
  METHODS
  Forty HD patients with hemoglobin (Hb) ≤ 11 g/dL, serum ferritin ≥ 500 ng/mL and transferrin saturation (TSAT) ≤ 25% were randomly divided into two groups. 20 patients received 100 mg of intravenous (IV) iron (group I), and 20 patients received 300 mg of IV ascorbic acid (group II) postdialysis, twice a week for 5 consecutive weeks. Hb and iron metabolism indices were measured before the onset of the study and after 12 weeks following therapy.
  
  
  RESULTS
  Twenty one percent of all HD patients, exhibited high serum ferritin, low TSAT and sufficient data for analysis. Both Group I (n = 20) and Group II (n = 20) patients showed a significant increase in Hb, serum iron, and TSAT (P < 0.001). There were no significant differences between both groups in increasing Hb (P = 0.076), serum iron (P = 0.589), serum ferritin (0.725), and TSAT (P = 0.887).
  
  
  CONCLUSIONS
  This study showed that both IV iron and IV ascorbic acid can improve FID in HD patients. A larger randomized trial is warranted to determine the optimal management of FID in HD patients.
authors.affiliation: Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Sedighi
authors.affiliation: Molecular and Cell Biology Research Center, Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Atieh
authors.initials: A
authors.lastname: Makhlough
authors.affiliation: Department of Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Janbabai
authors.affiliation: Department of Internal Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Neemi
keywords: Anemia, Iron-Deficiency; Ascorbic Acid; Renal Dialysis