title: In vitro study of the aortic interleaflet triangle reshaping.
abstract: Aortic interleaflet triangle reshaping (AITR) is a surgical approach to aortic valve incontinence that involves placing three stitches at half of the interleaflet triangles height. In this work, the relationship between the actual stitch height and valve functioning, and the safety margin that the surgeon can rely on in applying the stitches were systematically investigated in vitro. AITR surgery was applied to six swine aortic roots placing the stitches empirically at 50%, 60% and 75% of the triangle heights. Then the actual stitch heights were measured and the hydrodynamic performances were evaluated with a pulsatile hydrodynamic mock loop. Actual stitch heights were 45±2%, 61±4% and 79±6%. As compared to untreated conditions, the 50% configuration induced a significant variation in the effective orifice area. With stitches placed at 60%, the mean systolic pressure drop increased significantly with respect to the untreated case, but no significant changes were recorded with respect to the 50% configuration. At 75%, all the hydrodynamic parameters of systolic valve functioning worsened significantly. Summarizing, the AITR technique, when performed in a conservative manner did not induce significant alterations in the hydrodynamics of the aortic root in vitro, while more aggressive configurations did. The absence of a statistically significant difference between the 50% and 60% configurations suggests that there is a reasonably limited risk of inducing valve stenosis in the post-op scenario due to stitch misplacement.
authors.affiliation: Department of Electronic, Information and Bioengineering, Politecnico di Milano, via Golgi 39, Milan 20133, Italy; ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy. Electronic address: riccardo.vismara@polimi.it.
authors.forename: R
authors.initials: R
authors.lastname: Vismara
authors.affiliation: Department of Electronic, Information and Bioengineering, Politecnico di Milano, via Golgi 39, Milan 20133, Italy; ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Leopaldi
authors.affiliation: ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy; Cardiovascular Surgery Department, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mangini
authors.affiliation: ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy; Cardiovascular Surgery Department, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Romagnoni
authors.affiliation: ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy; Cardiovascular Surgery Department, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Contino
authors.affiliation: ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy; Cardiovascular Surgery Department, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Antona
authors.affiliation: Department of Electronic, Information and Bioengineering, Politecnico di Milano, via Golgi 39, Milan 20133, Italy; ForCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Fiore
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000502:physiology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001794:Blood Pressure; D006801:Humans; D057446:Hydrodynamics; D066298:In Vitro Techniques; D013536:Suture Techniques; D013552:Swine
keywords: Aortic valve; In vitro tests; Interleaflet triangle reshaping; Reparative surgery