title: Quantification of aortic regurgitation using high-pulse repetition frequency three-dimensional colour Doppler.
abstract: OBJECTIVE
  The aim of this study was to validate and assess the feasibility of a previously described method using multibeam high-pulse repetition frequency (HPRF) colour Doppler to quantify the vena contracta area (VCA) in aortic regurgitation (AR).
  
  
  METHODS
  Twenty-nine patients with mild to severe AR were studied. Regurgitant volume and fraction measured by magnetic resonance imaging (MRI) were used as the standard of reference. The VCA was measured automatically by combining the Doppler power from multiple beams with a priori knowledge of the individual beam profiles, to give an absolute measurement of the VCA. The regurgitant volume was calculated as the product of the VCA and the velocity time integral, measured separately by continuous wave Doppler.
  
  
  RESULTS
  The Spearman's rank correlation between regurgitant volume by MRI and multibeam HPRF colour Doppler was rs = 0.73 (P < 0.01), with 95% limits of agreement of -14.4 ± 29.1 mL. The mean difference between the methods in those with MRI regurgitant volume of ≥30 mL (n = 14) was -7.6 (95% confidence interval -13.9 to -1.2) mL.
  
  
  CONCLUSIONS
  There was good agreement between MRI and multibeam HPRF colour Doppler in patients with moderate to severe AR, while agreement for those with mild AR was modest.
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway Department of Cardiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway thomas.r.skaug@ntnu.no.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Skaug
authors.affiliation: Department of Cardiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway Department of Radiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway MI lab and Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
authors.forename: Brage H
authors.initials: BH
authors.lastname: Amundsen
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway.
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Hergum
authors.affiliation: Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Stig
authors.initials: S
authors.lastname: Urheim
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway.
authors.forename: Hans
authors.initials: H
authors.lastname: Torp
authors.affiliation: Department of Cardiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway MI lab and Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
authors.forename: Bjørn Olav
authors.initials: BO
authors.lastname: Haugen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002908:Chronic Disease; D015331:Cohort Studies; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult
keywords: 3D colour Doppler; Aortic regurgitation; Multibeam HPRF colour Doppler; Regurgitant volume; Vena contracta area