title: Haemoglobin A1c: comparing performance of two point of care devices with laboratory analyser.
abstract: BACKGROUND
  Measurement of HbA1c has been widely used for long-term monitoring and management of diabetes control. There is increasing use of point-of-care (POC) devices for measuring HbA1c where quicker results would allow immediate clinical management decisions to be made. Therefore, it is important to evaluate and compare the performance of such devices to the reference laboratory method.
  
  
  RESULTS
  A total of 274 venous blood was collected from normal healthy adults during the community screening programmes. The performance of POC devices, Afinion and Quo-test were compared to central laboratory HPLC method; Adams A1c HA 8160. Both POC devices showed good correlation to HA 8160 with r = 0.94 (p < 0.001) and r = 0.95 (p < 0.001) for Afinion and Quo-test respectively. The means difference were statistically higher between POC and HA 8160 with 0.23% (95% CI 0.19-0.26, p < 0.001) and 0.29% (95% CI 0.24-0.34, p < 0.001) for Afinion and Quo-test respectively.
  
  
  CONCLUSIONS
  Both POC devices could be considered in health clinics for diabetes management but not to be used for the diagnostic purposes.
authors.affiliation: Department of Diabetes & Endocrine, Cardiovascular Diabetes and Nutrition Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, 50588, Malaysia. ruziana.mona@gmail.com.
authors.forename: Ruziana Mona
authors.initials: RM
authors.lastname: Wan Mohd Zin
authors.forename: Zati Iwani
authors.initials: ZI
authors.lastname: Ahmad Kamil
authors.forename: Tuan Rosidah
authors.initials: TR
authors.lastname: Tuan Soh
authors.forename: Mustaffa
authors.initials: M
authors.lastname: Embong
authors.forename: Wan Nazaimoon
authors.initials: WN
authors.lastname: Wan Mohamud
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007753:Laboratories / Q000592:standards; D008297:Male; D008403:Mass Screening; D019095:Point-of-Care Systems / Q000592:standards*
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human