title: Increase of peripheral blood TCD8+ cells in women with recurrent miscarriage.
abstract: Recurrent miscarriage (RM) is one of the most prevalent reproductive problems faced by couples that may affect as many as 2% of women in reproductive age. The causes of its abnormality have attracted the attention of many researchers. We aim to determine the different T-cell subsets in women with RM and normal control. In this prospective case-control study, peripheral blood was taken from women with RM (n = 25) and normal women (n = 17), during the mid-luteal phase. The percentage of CD3, CD3(+)CD4(+), CD3(+)CD8(+) markers and also CD4/CD8 ratio was detected in the patients and control group by flow cytometry. The proportion of TCD8(+) was significantly higher in RM women compared with the control group (p < 0.05). However, there was no statistical difference in percentage of total TCD3(+) and TCD4(+) cells between the RM and control women. Also, the CD4/CD8 ratio was lower in the RM women compared with the control women. These observations support the concept that increase of TCD8(+) lymphocytes could be involved in the aetiology of RM.
authors.affiliation: Hemoglobinopathy and Thalassemia Research Center.
authors.forename: M
authors.initials: M
authors.lastname: Ghafourian
authors.forename: A
authors.initials: A
authors.lastname: Abuhamidy
authors.forename: N
authors.initials: N
authors.lastname: Karami
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D011247:Pregnancy