title: Synthesis, characterization, cytotoxicity and antibacterial activity of an anthracenyl-linked bis(pyrazolyl)methane ligand and its zinc(II) complexes.
abstract: Three novel Zn(II) complexes (1-3) with 1,1'-(anthracen-9-ylmethylene)bis(1H-pyrazole) (L(2)) have been prepared and structurally characterized by X-ray crystallography. Among them, 1 is a binuclear Zn(II) complex while 2 and 3 are mononuclear. The in vitro cytotoxic and antibacterial activities of these complexes were also evaluated. The three complexes exhibit cytotoxic specificity and significant antitumor activity. The MIC50 value of complex 1 against Pseudomonas putida reaching 0.011 μg/mL much lower than that the positive control chloromycin (0.182 μg/mL), indicates that complex 1 is a potent antibacterial agent.
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei 230009, PR China.
authors.forename: Ban-Feng
authors.initials: BF
authors.lastname: Ruan
authors.affiliation: Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China.
authors.forename: Ying-Zhong
authors.initials: YZ
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China.
authors.forename: Wan-Ding
authors.initials: WD
authors.lastname: Liu
authors.affiliation: Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China. Electronic address: songbaoan22@yahoo.com.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Song
authors.affiliation: Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China. Electronic address: yptian@ahu.edu.cn.
authors.forename: Yu-Peng
authors.initials: YP
authors.lastname: Tian
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011720:Pyrazoles; D015032:Zinc; D008697:Methane
keywords: 1,1′-(Anthracen-9-ylmethylene)bis(1H-pyrazole); Antibacterial activity; Crystal structure; Cytotoxicity; Zinc(II) complex