title: Epigenetic regulation of HIV-1 latency in astrocytes.
abstract: HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes. We have shown that class I histone deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significant role in silencing of HIV transcription in astrocytes. Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV.
authors.affiliation: Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA.
authors.forename: Srinivas D
authors.initials: SD
authors.lastname: Narasipura
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kim
authors.forename: Lena
authors.initials: L
authors.lastname: Al-Harthi
mesh_terms: D001253:Astrocytes / Q000378:metabolism / Q000821:virology*; D002460:Cell Line; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D015658:HIV Infections / Q000821:virology; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000502:physiology*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000378:metabolism; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000821:virology; D010879:Piperazines / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic / Q000187:drug effects; D016662:Virus Integration; D017735:Virus Latency / Q000235:genetics*
chemical_list: D056572:Histone Deacetylase Inhibitors; D010879:Piperazines; C002511:chaetocin; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D006655:Histone Deacetylases