title: Manganese acquisition and homeostasis at the host-pathogen interface.
abstract: Pathogenic bacteria acquire transition metals for cell viability and persistence of infection in competition with host nutritional defenses. The human host employs a variety of mechanisms to stress the invading pathogen with both cytotoxic metal ions and oxidative and nitrosative insults while withholding essential transition metals from the bacterium. For example, the S100 family protein calprotectin (CP) found in neutrophils is a calcium-activated chelator of extracellular Mn and Zn and is found in tissue abscesses at sites of infection by Staphylococcus aureus. In an adaptive response, bacteria have evolved systems to acquire the metals in the face of this competition while effluxing excess or toxic metals to maintain a bioavailability of transition metals that is consistent with a particular inorganic "fingerprint" under the prevailing conditions. This review highlights recent biological, chemical and structural studies focused on manganese (Mn) acquisition and homeostasis and connects this process to oxidative stress resistance and iron (Fe) availability that operates at the human host-pathogen interface.
authors.affiliation: Graduate Program in Biochemistry, Indiana University Bloomington, IN, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Lisher
authors.affiliation: Graduate Program in Biochemistry, Indiana University Bloomington, IN, USA ; Department of Chemistry, Indiana University Bloomington, IN, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Giedroc
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001424:Bacterial Infections / Q000382:microbiology; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D008345:Manganese / Q000378:metabolism*
chemical_list: D008345:Manganese
keywords: ATP-binding cassette; homeostasis; iron; manganese; metal transport; nutritional immunity