title: [Plasma cell leukemia: three case-reports and review of literature].
abstract: Plasma cell leukemia (LP) is a rare hematologic malignancy. Its prognosis is very derogatory. It is defined by the presence in circulating blood of more than 2 G/L plasmocytes or greater than 20% of the total leukocytes. It comes in two forms: secondary plasma cell leukemia complicating multiple myeloma (MM) and primary setting. Its incidence is estimated at 0.9% of patients with acute leukemia and 2-4% of patients with MM. We report, through three observations, the clinical presentation of the plasma cell leukemia, its cytological features, immunophenotypic, physiopathological and therapeutic care.
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: Hicham
authors.initials: H
authors.lastname: Eddou
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: El Mehdi
authors.initials: el M
authors.lastname: Mahtat
authors.affiliation: Laboratoire d'hématologie, Hôpital militaire d'instruction Mohamed V Rabat, Maroc.
authors.forename: Hamid
authors.initials: H
authors.lastname: Zahid
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: Hicham El
authors.initials: HE
authors.lastname: Maaroufi
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: Selim
authors.initials: S
authors.lastname: Jennane
authors.affiliation: Laboratoire d'hématologie, Hôpital militaire d'instruction Mohamed V Rabat, Maroc.
authors.forename: Nezha
authors.initials: N
authors.lastname: Messaoudi
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: Kamal
authors.initials: K
authors.lastname: Doghmi
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohamed V Rabat, Maroc, Maroc.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mikdame
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D064592:Autografts; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004164:Diphosphonates / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009018:Morocco; D011719:Pyrazines / Q000008:administration & dosage; D012074:Remission Induction; D013792:Thalidomide / Q000008:administration & dosage
chemical_list: D001897:Boronic Acids; D004164:Diphosphonates; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone
keywords: leukemia; plasma cell; plasmocyte