title: Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization.
abstract: OBJECTIVE
  To assess the effect of unilateral oophorectomy (UO) by assessing ovarian reserve (OVR) and the response to gonadotropin stimulation in women with UO undergoing in vitro fertilization (IVF) compared with the response of the ipsilateral ovary of women without UO.
  
  
  METHODS
  Historical cohort study.
  
  
  METHODS
  Academic fertility clinic.
  
  
  METHODS
  Fifty-one women with single ovary compared with a referent group with both ovaries in a 1:2 fashion.
  
  
  METHODS
  None.
  
  
  METHODS
  Day-3 follicle-stimulating hormone (FSH), estradiol, and antral follicle counts as measures of OVR, and IVF outcomes including number of follicles aspirated and oocytes retrieved.
  
  
  RESULTS
  The baseline demographics and serum markers of OVR were not different. Referent women had greater follicular yield and oocyte numbers when compared with women with UO; however, when compared with the ipsilateral ovary of the referents, women with UO had a higher antral follicle count and greater follicle and oocyte numbers. In multivariate analyses, the ovary from women with UO was more likely to yield more than the median number of follicles and oocytes than the ipsilateral ovary in referent women. Live-birth rates in both groups were similar.
  
  
  CONCLUSIONS
  Our results suggest that the remaining ovary appears to compensate in follicular yield after UO in women, confirming the animal data. Women with UO can be reassured and appropriately counseled regarding IVF.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota. Electronic address: khan.zaraq@mayo.edu.
authors.forename: Zaraq
authors.initials: Z
authors.lastname: Khan
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Gada
authors.affiliation: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Zaid M
authors.initials: ZM
authors.lastname: Tabbaa
authors.affiliation: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Shannon K
authors.initials: SK
authors.lastname: Laughlin-Tommaso
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Jani R
authors.initials: JR
authors.lastname: Jensen
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Coddington
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods*; D006080:Ovarian Follicle / Q000502:physiology*; D010052:Ovariectomy / Q000379:methods*; D010053:Ovary / Q000166:cytology / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*
keywords: Compensatory follicular recruitment; in vitro fertilization; ovarian reserve; unilateral oophorectomy