title: Causes and consequences of replication stress.
abstract: Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.
authors.affiliation: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Zeman
authors.affiliation: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Karlene A
authors.initials: KA
authors.lastname: Cimprich
mesh_terms: D004261:DNA Replication; D004194:Disease; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D013312:Stress, Physiological