title: Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs.
abstract: For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, (111)In- and (177)Lu-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling.
authors.affiliation: Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: de Blois
authors.affiliation: Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Ho Sze
authors.initials: HS
authors.lastname: Chan
authors.affiliation: Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Rory
authors.initials: R
authors.lastname: de Zanger
authors.affiliation: Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Mark
authors.initials: M
authors.lastname: Konijnenberg
authors.affiliation: Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. Electronic address: w.a.p.breeman@erasmusmc.nl.
authors.forename: Wouter A P
authors.initials: WA
authors.lastname: Breeman
mesh_terms: D001205:Ascorbic Acid; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D000431:Ethanol; D005841:Gentisates; D006801:Humans; D007205:Indium Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use; D008187:Lutetium / Q000008:administration & dosage* / Q000627:therapeutic use; D011868:Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000627:therapeutic use; D012996:Solutions; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D005841:Gentisates; D007205:Indium Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012996:Solutions; D000431:Ethanol; D013004:Somatostatin; D008187:Lutetium; D001205:Ascorbic Acid; C010925:2,5-dihydroxybenzoic acid
keywords: Ascorbic acid; Ethanol; Gentisic acid; Quenchers; Radiochemical purity; Somatostatin