title: Donor hemosiderosis does not affect liver function and regeneration in the setting of living donor liver transplantation.
abstract: Living donor liver transplantation (LDLT) demands a careful assessment of abnormal findings discovered during the evaluation process to determine if there will be any potential risks to the donor or recipient. Varying degrees of elevated hepatic iron levels are not uncommonly seen in otherwise healthy individuals. We questioned whether mild expression of hemosiderin deposition presents a safety concern when considering outcomes of living donation for both the donor and the recipient. We report on three LDLT patients who were found to have low- to moderate-grade hemosiderin deposition on liver biopsy. All other aspects of their evaluation proved satisfactory, and the decision was made to proceed with donation. There were no significant complications in the donors, and all demonstrated complete normalization of liver function postoperatively, with appropriate parenchymal regeneration. The recipients also had unremarkable postoperative recovery. We conclude that these individuals can be considered as potential donors after careful evaluation.
authors.affiliation: Department of Surgery, Division of Transplantation, Hospital of the University of Pennsylvania, Philadelphia, PA.
authors.forename: O
authors.initials: O
authors.lastname: Shaked
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez
authors.forename: R
authors.initials: R
authors.lastname: Bahirwani
authors.forename: E
authors.initials: E
authors.lastname: Furth
authors.forename: E
authors.initials: E
authors.lastname: Siegelman
authors.forename: A
authors.initials: A
authors.lastname: Shaked
authors.forename: K
authors.initials: K
authors.lastname: Olthoff
authors.forename: K R
authors.initials: KR
authors.lastname: Reddy
mesh_terms: D000328:Adult; D005260:Female; D006486:Hemosiderosis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000502:physiology; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D055815:Young Adult
keywords: Hemochromatosis; hemosiderosis; hepatic iron; liver function; living donor; regeneration