title: Validation of metrics for the detection of subclinical keratoconus in a new patient collective.
abstract: OBJECTIVE
  To validate the discriminative ability of wavefront- and pachymetry-based corneal topographic metrics to detect subclinical keratoconus in a new patient collective.
  
  
  METHODS
  Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
  
  
  METHODS
  Retrospective cross-sectional study.
  
  
  METHODS
  Normal fellow eyes with early keratoconus and preoperative eyes with an uneventful follow-up without signs of iatrogenic keratectasia 12 months after laser in situ keratoconus were included. Zernike coefficients from the anterior and posterior surfaces and corneal thickness spatial profiles and corresponding discriminant functions were assessed for their usefulness to discriminate between eyes with subclinical keratoconus and normal eyes using receiver-operating-characteristic (ROC) curve analysis. Discriminant functions were obtained from a previous study and constructed de novo from the present collective.
  
  
  RESULTS
  The anterior C(1,-1) and C(3,-1) coefficients had the highest area under the ROC curve (both 0.87). The anterior 5th-order root mean square (RMS) was the RMS value with the maximum area under the ROC curve (0.90). The discriminant function with input from anterior and posterior Zernike coefficients (DAP) and DAP including pachymetry data (DAPT) performed best (area under ROC curve 0.864 and 0.857, respectively). Applying cutoff values from a previous study resulted in a minimal drop in accuracy (0.0% to 1.3%). The construction of discriminant functions from the present dataset resulted in a gain in accuracy of between 3.5% and 9.6%, with DAPT reaching the maximum area under the ROC curve of 0.956.
  
  
  CONCLUSIONS
  Validation in a new and larger patient collective proved the usefulness of metrics based on corneal wavefront and pachymetry for the detection of subclinical keratoconus.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany. Electronic address: buehren@em.uni-frankfurt.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Bühren
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schäffeler
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
mesh_terms: D057128:Aberrometry / Q000379:methods*; D000293:Adolescent; D000328:Adult; D001699:Biometry / Q000379:methods*; D003315:Cornea / Q000473:pathology*; D063171:Corneal Pachymetry / Q000379:methods*; D019781:Corneal Topography / Q000379:methods*; D003430:Cross-Sectional Studies; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000601:surgery; D007640:Keratoconus / Q000175:diagnosis*; D020731:Keratomileusis, Laser In Situ; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult