title: Study on hyperuricemia in HBV-associated glomerulonephritis.
abstract: OBJECTIVE
  To determine the prevalence and risk factors for hyperuricemia in hepatitis B virus-associated glomerulonephritis (HBV-GN).
  
  
  METHODS
  Univariate and multivariate logistic regression analysis was applied to decide the risk factors of hyperuricemia in HBV-GN, and clinical and pathologic data were compared between HBV-GN patients with hyperuricemia and those with normal serum uric acid.
  
  
  RESULTS
  Among our 227 HBV-GN cases, 31.3% of the patients had hyperuricemia at the time of renal biopsy. Univariate analysis showed that the level of serum creatinine and the severity of glomerular and tubular interstitial injury were significantly related to hyperuricemia. Multivariate logistic regression analysis identified the levels of serum creatinine and tubular interstitial injury as independent factors for hyperuricemia. The incidence of hypertension and lower estimated glomerular filtration rate was significantly higher in hyperuricemic patients with HBV-GN than in normouricemic patients. There were also fewer membranous nephropathy, more proliferative sclerosing glomerulonephritis, and more tubular interstitial injury in hyperuricemic patients with HBV-GN.
  
  
  CONCLUSIONS
  Our study results suggest that hyperuricemia is common in HBV-GN, which may facilitate the progression of HBV-GN and renal tubular interstitial injury as well as the development of hypertension.
authors.affiliation: Dept of Nephrology, Fuzhou General Hospital of Nanjing Military Command, 156 Xier'Huan N Rd, Fuzhou, Fujian 350025, China; zhuangyongze@126.com.
authors.forename: Yongze
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Yu
authors.forename: Yingfang
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Zhong
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications* / Q000473:pathology; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D007684:Kidney Tubules / Q000293:injuries; D015995:Prevalence; D012307:Risk Factors
chemical_list: D003404:Creatinine
keywords: Glomerular filtration rate; HBV-associated glomerulonephritis; Hyperuricemia; Tubular interstitial injury