title: Levels of inflammatory cytokines in type 2 diabetes patients with different urinary albumin excretion rates and their correlation with clinical variables.
abstract: Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P < 0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P < 0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P < 0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN.
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Fen-Qin
authors.initials: FQ
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Fengtian Hospital of Shenyang Medical College, Shenyang 110000, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, The Fourth People's Hospital of Shenyang, Shenyang 110031, China.
authors.forename: Xiu-Bin
authors.initials: XB
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Dong-Wei
authors.initials: DW
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Qiu-Yue
authors.initials: QY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000418:Albumins; D016207:Cytokines; D018836:Inflammation Mediators