title: Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma.
abstract: A 57-year-old woman presented with periorbital ecchymoses, laxity in skin folds, polyneuropathy and bilateral carpal tunnel syndrome. A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. The diagnosis of primary systemic amyloidosis was made by the presence of amyloid material in the eyelid using histopathological techniques, besides this, the patient was also diagnosed with purpura, polyneuropathy, bilateral carpal tunnel syndrome and monoclonal gammopathy. She was diagnosed as suffering from multiple myeloma based on the finding of 40% plasma cells in the bone marrow, component M in the urine and anemia. The patient developed blisters with a clear content, confirmed as mucinosis by the histopathological exam. The final diagnoses were: primary systemic amyloidosis, acquired cutis laxa and mucinosis, all related to multiple myeloma.
authors.affiliation: Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Fernanda Guedes
authors.initials: FG
authors.lastname: Lavorato
authors.affiliation: Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Maria de Fátima Guimarães Scotelaro
authors.initials: Mde F
authors.lastname: Alves
authors.affiliation: Rio de Janeiro Federal University, Rio de JaneiroRJ, Brazil.
authors.forename: Juan Manuel Piñeiro
authors.initials: JM
authors.lastname: Maceira
authors.affiliation: Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Natasha
authors.initials: N
authors.lastname: Unterstell
authors.affiliation: Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Laura Araújo
authors.initials: LA
authors.lastname: Serpa
authors.affiliation: Rio de Janeiro State University.
authors.forename: Luna
authors.initials: L
authors.lastname: Azulay-Abulafia
mesh_terms: D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D003483:Cutis Laxa / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D008875:Middle Aged; D017520:Mucinoses / Q000473:pathology*; D009101:Multiple Myeloma / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*