title: Etiology of pleural effusions: analysis of more than 3,000 consecutive thoracenteses.
abstract: OBJECTIVE
  To investigate the etiology of pleural effusions (PE) in adults and the accuracy of pleural fluid (PF) cytology and cultures in malignant and infectious PE, respectively.
  
  
  METHODS
  Retrospective analysis of all consecutive patients with PE undergoing diagnostic thoracentesis during the last 19 years in a university hospital.
  
  
  RESULTS
  The leading causes of PE among the 3,077 patients were: cancer (27%), heart failure (21%), pneumonia (19%), tuberculosis (9%), abdominal surgery (4%), pericardial diseases (4%) and cirrhosis (3%). Tuberculosis was the most common etiology in patients <34 years of age (52%), whereas heart failure predominated in octogenarians (45%). The most common primary tumors in malignant PE were lung (37%) and breast (16%). The overall accuracy of PF cytology was 59%, although it was significantly lower in mesotheliomas (27%) and squamous cell lung cancer (25%). In infectious PE, only 30% of cultures yielded positive results, a percentage which increased two-fold (66%) in purulent fluids (empyemas). Viridans streptococci were the most commonly isolated pathogens (25.5%). The sensitivity of solid media cultures of PF for Mycobacterium tuberculosis was low (18.5%).
  
  
  CONCLUSIONS
  Three-quarters of patients with PE in whom a diagnostic thoracentesis was indicated had cancer, heart failure, pneumonia or tuberculosis. PF cytology and cultures give false negative results in a significant number of cases.
authors.affiliation: Unidad de Enfermedades de la Pleura, Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, Lleida, España. Electronic address: jporcelp@yahoo.es.
authors.forename: José M
authors.initials: JM
authors.lastname: Porcel
authors.affiliation: Servicio de Análisis Clínicos, Hospital Universitario Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, Lleida, España.
authors.forename: Aureli
authors.initials: A
authors.lastname: Esquerda
authors.affiliation: Servicio de Medicina Interna, idcsalud Hospital Albacete, Albacete, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Vives
authors.affiliation: Unidad de Enfermedades de la Pleura, Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, Lleida, España.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bielsa
mesh_terms: D000368:Aged; D005122:Exudates and Transudates / Q000166:cytology / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D012189:Retrospective Studies
keywords: Cancer; Cáncer; Derrame pleural; Heart failure; Insuficiencia cardiaca; Neumonía; Pleural effusion; Pneumonia; Thoracentesis; Toracocentesis; Tuberculosis