title: [Growth Hormone-Insulin Growth Factor I (GH-IGF-I) axis and growth].
abstract: Normal human linear growth results from an evolutionary process expressing the sum effect of multiple genes. The growth hormone (GH) - insulin like growth factor (IGF)-I axis is one of the main actors in the growth process. Defects in this axis can be responsible for short or tall stature. Short stature is defined as smaller than - 2 standard deviations (SD). It is a very common reason for consultation in pediatrics; indeed, 2.5 % of children are concerned. Multiple causes make diagnosis difficult. In this article, we detail the most common constitutional causes of small size, including those related to a defect in the GH-IGF-I axis. Then, we report, the first results of the clinical and genetic study conducted on 213 patients with gigantism. Tall stature is defined by a height superior to 2 SD. Finally, recent work linking epigenetics and growth - via signaling pathways of GH-IGF-I axis - will be presented.
authors.affiliation: Service d'endocrinologie, Hôpital Archet 2, 151, route Saint-Antoine-de-Ginestière, 06200 Nice, France. Electronic address: castellannelaure@live.fr.
authors.forename: A-L
authors.initials: AL
authors.lastname: Castell
authors.affiliation: Service d'endocrinologie, Hôpital Archet 2, 151, route Saint-Antoine-de-Ginestière, 06200 Nice, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Sadoul
authors.affiliation: Services d'endocrinologie pédiatrique et adulte, Hôpital Bicêtre, AP-HP, Université Paris-Sud, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouvattier
mesh_terms: D001827:Body Height; D004351:Drug Resistance; D044127:Epigenesis, Genetic; D005877:Gigantism / Q000235:genetics; D006128:Growth / Q000235:genetics / Q000502:physiology*; D006130:Growth Disorders / Q000209:etiology* / Q000235:genetics; D019382:Human Growth Hormone / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D011986:Receptors, Somatotropin / Q000235:genetics; D015398:Signal Transduction
chemical_list: D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I
keywords: Epigenetic; GH; Gigantism; Gigantisme; Growth hormone; IGF-I; Insulin-like growth factor I; Retard statural; Short stature; Épigénétique