title: [Significance of MACC1 protein expression in esophageal carcinoma].
abstract: OBJECTIVE
  To explore the expression of metastasis-associated colon cancer 1 (MACC1) proteins in esophageal carcinoma and neighboring tissues.
  
  
  METHODS
  The expressions of MACC1 were detected in 60 specimens of esophageal carcinoma and neighboring tissues with immunohistochemistry and Western blotting. All the specimens were selected from 2010-2012 of Guangfu Hospital of Jinhua, 38 males and 22 females, aged (50 ± 12) years. And the correlations of the expressions of MACC1 proteins with the clinicopathologic features of esophageal carcinoma were also analyzed.
  
  
  RESULTS
  Expression of MACC1 protein was predominantly located in cytoplasm and membrane. The positivity rates of MACC1 protein were 68.3% (41/60) in esophageal carcinoma tissue and there were significant differences from those in neighboring tissue (25.0(15/60), P < 0.01). Western blotting analysis showed that the expression level of MACC1 protein in esophageal carcinoma was greater than that in corresponding adjacent tissues (0.64 ± 0.05 vs 0.21 ± 0.10, P < 0.05). Moreover, the positivity rates and relative expressions of MACC1 showed significant correlations with TNM stage and pathology grade (all P < 0.05).
  
  
  CONCLUSIONS
  The abnormal expression of MACC1 may be associated with malignant progression of esophageal carcinoma.
authors.affiliation: Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua 321000, China. Email: 13757981180@163.com.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua 321000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hong
authors.affiliation: Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua 321000, China.
authors.forename: Cong-gang
authors.initials: CG
authors.lastname: Hu
authors.affiliation: Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua 321000, China.
authors.forename: Yue-jun
authors.initials: YJ
authors.lastname: Fang
authors.affiliation: Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua 321000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D015153:Blotting, Western; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors