title: Metastatic germ cell tumour following renal transplantation.
abstract: BACKGROUND
  Treatment of germ cell tumours with cisplatin-based chemotherapy results in cure for the majority of patients. There is, however, a small but significant mortality rate, reported to be higher in patients with multiple co-morbidities.
  
  
  METHODS
  We report our management of a renal transplant patient with spina bifida, who was diagnosed with stage IIIC, poor-risk, non-seminomatous germ cell carcinoma. A marker-negative partial response, which has been maintained more than 2 years following completion of treatment, was seen following chemotherapy with cisplatin and etoposide. Performance status has been preserved at pre-treatment levels.
  
  
  CONCLUSIONS
  Administration of cisplatin-based chemotherapy is feasible for treatment of renal transplant patients with advanced non-seminomatous germ cell tumours. Treatment strategies require careful planning and monitoring. Dose modifications may be required. This case highlights a favourable outcome in spite of multiple obstacles to ideal management.
authors.affiliation: Department of Medical Oncology, Cork University Hospital, Ireland.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Graham
authors.forename: William D
authors.initials: WD
authors.lastname: Plant
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Mayer
authors.forename: Derek G
authors.initials: DG
authors.lastname: Power
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000556:secondary*; D016135:Spinal Dysraphism / Q000150:complications; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D002945:Cisplatin