title: Circulating biomarkers for detection of ovarian cancer and predicting cancer outcomes.
abstract: BACKGROUND
  Securing a diagnosis of ovarian cancer and establishing means to predict outcomes to therapeutics remain formidable clinical challenges. Early diagnosis is particularly important since survival rates are markedly improved if tumour is detected early.
  
  
  METHODS
  Comprehensive miRNA profiles were generated on presurgical plasma samples from 42 women with confirmed serous epithelial ovarian cancer, 36 women diagnosed with a benign neoplasm, and 23 comparably age-matched women with no known pelvic mass.
  
  
  RESULTS
  Twenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P<0.05), while a six miRNA profile subset distinguished presurgical plasma from benign and ovarian cancer patients. There were also significant differences in miRNA profiles in presurgical plasma from women diagnosed with ovarian cancer who had short overall survival when compared to women with long overall survival (P<0.05).
  
  
  CONCLUSIONS
  Our preliminary data support the utility of circulating plasma miRNAs to distinguish women with ovarian cancer from those with a benign mass and identify women likely to benefit from currently available treatment for serous epithelial ovarian cancer from those who may not.
authors.affiliation: 1] Monter Cancer Center, NorthShore LIJ, 450 Lakeville Road, Lake Success, NY 11040, USA [2] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.affiliation: The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Oswald
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Gynecology/Oncology, NorthShore LIJ, 300 Community Drive, Manhasset, NY 11030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lovecchio
authors.affiliation: The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: H
authors.initials: H
authors.lastname: Khalili
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Gynecology/Oncology, NorthShore LIJ, 300 Community Drive, Manhasset, NY 11030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Menzin
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Gynecology/Oncology, NorthShore LIJ, 300 Community Drive, Manhasset, NY 11030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Whyte
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Gynecology/Oncology, NorthShore LIJ, 300 Community Drive, Manhasset, NY 11030, USA.
authors.forename: L
authors.initials: L
authors.lastname: Dos Santos
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Pathology, NorthShore LIJ, 5 Ohio Drive, New Hyde Park, NY 11040, USA.
authors.forename: S
authors.initials: S
authors.lastname: Liang
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Pathology, NorthShore LIJ, 5 Ohio Drive, New Hyde Park, NY 11040, USA.
authors.forename: T
authors.initials: T
authors.lastname: Bhuiya
authors.affiliation: The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Keogh
authors.affiliation: The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: C
authors.initials: C
authors.lastname: Mason
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] Department of Gastroenterology, NorthShore LIJ, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: K
authors.initials: K
authors.lastname: Sultan
authors.affiliation: 1] Monter Cancer Center, NorthShore LIJ, 450 Lakeville Road, Lake Success, NY 11040, USA [2] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Budman
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Gregersen
authors.affiliation: 1] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA [2] The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000235:genetics / Q000401:mortality*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000235:genetics / Q000401:mortality*; D013534:Survival; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs