title: Lhermitte-Duclos disease. A case report.
abstract: Lhermitte-Duclos disease is a rare pathologic condition consisting of a dysplastic gangliocytoma of the cerebellum. Its association with phacomatosis and an autosomal dominant neoplastic syndrome, Cowden's syndrome is also known. Modern neuroimaging contributes to a correct diagnosis and pre- and postoperative evaluation. Here we describe the morphologic and metabolic aspects of the disease as shown by conventional MRI, diffusion imaging and spectroscopy in a 31-year-old woman. In addition, the specific neuroradiologic characteristics are presented and discussed in the light of the main pathologic and clinical features, such as hypertrophy of the cerebellar folia associated with white matter atrophy.
authors.affiliation: Department of Neuroradiology, Circolo Fondazione Macchi Hospital; Varese, Italy - pellegrino.carlo82@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giorgianni
authors.forename: Carlo
authors.initials: C
authors.lastname: Pellegrino
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Benedictis
authors.forename: Anna
authors.initials: A
authors.lastname: Mercuri
authors.forename: Fabio
authors.initials: F
authors.lastname: Baruzzi
authors.forename: Renzo
authors.initials: R
authors.lastname: Minotto
authors.forename: Antonio
authors.initials: A
authors.lastname: Tabano
authors.forename: Sergio
authors.initials: S
authors.lastname: Balbi
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
keywords: CT and MR imaging; Lhermitte-Duclos disease; brain tumor