title: Amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis.
abstract: Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. The most common forms of systemic amyloidosis are primary amyloidosis (PA) of light chains and secondary amyloidosis (SA) caused by chronic inflammatory diseases such as rheumatoid arthritis (RA). Although involvement of the thyroid gland by amyloid is a relatively common phenomenon, clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. In SA, the deposition of amyloid associated (AA) protein is associated with atrophy of thyroid follicles. The clinical picture of these patients is characterized by rapid, painless thyroid gland enlargement which may be associated with dysphagia, dyspnea, or hoarseness. Thyroid function is not impaired in most cases. Although amyloid goitre secondary to systemic amyloidosis due to chronic inflammatory diseases is relatively common, specifically related to RA is much more uncommon one and it is reported less in the literature. In this report, A 52-old-year female patient with amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis is presented.
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Gungor
authors.initials: G
authors.lastname: Uzum
authors.affiliation: Department of Internal Medicine, Istanbul Education and Research Hospital, Turkey.
authors.forename: Fatih Oner
authors.initials: FO
authors.lastname: Kaya
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Ayse Kubat
authors.initials: AK
authors.lastname: Uzum
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Kucukyilmaz
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Gunes
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Yigit
authors.initials: Y
authors.lastname: Duzkoylu
authors.affiliation: Department of Pathology, Istanbul Education and Research Hospital, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Leblebici
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Koc
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Turkey.
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Sari