title: [Treatment of corneal ulcers with platelet rich plasma].
abstract: OBJECTIVE
  To assess the efficacy of platelet rich plasma (PRP) in the treatment of extensive corneal ulcers in albino rabbits.
  
  
  METHODS
  New Zealand rabbits, divided in 3 groups, were used for the study. Corneal ulcers of 10mm diameter were made. Rabbits blood was extracted for the preparation of the PRP of the corresponding group. The blood was processed by differential centrifugation. The first group, named control, was treated with sterile saline every 8h. The second group, named gel, was treated with deproteinized extract gel beef fat every 8h, and the third group, named PRP received one PRP drop on the first and third day of monitoring. The rabbits were monitored, by taking photographs, each day for the 7 days that the study lasted.
  
  
  RESULTS
  A better outcome was observed in the group with deproteinized extract gel beef fat (GE group), and the PRP group (PL group), in comparison with the control group (CO group) (P<.05).
  
  
  CONCLUSIONS
  The PRP showed to be just as effective as the commercial product (Solcoseryl®), for the regeneration of the extensive and deep corneal ulcers. Besides, it stands out as a no surgical procedure is required, and there is easy access, low cost and reduced doses.
authors.affiliation: Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Acosta
authors.affiliation: Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Castro
authors.affiliation: Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Fernandez
authors.affiliation: Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Oliveres
authors.affiliation: Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Gomez-Demmel
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: i.tartara@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Tartara
mesh_terms: D000183:Actihaemyl / Q000008:administration & dosage / Q000627:therapeutic use; D000273:Adipose Tissue; D000818:Animals; D002417:Cattle; D003320:Corneal Ulcer / Q000628:therapy*; D005782:Gels; D007322:Instillation, Drug; D053657:Platelet-Rich Plasma; D011817:Rabbits; D062326:Re-Epithelialization; D016896:Treatment Outcome
chemical_list: D005782:Gels; D000183:Actihaemyl
keywords: Autologous serum; Corneal ulcers; Plasma rico en plaqueta; Platelet-rich plasma; Rabbits; Suero autólogo Conejos; Tratamiento; Treatment; Úlcera corneal