title: Noninvasive prenatal detection of aneuploidy.
abstract: Noninvasive prenatal testing (NIPT) uses cell-free fetal DNA from the plasma of pregnant women to provide valuable information about the potential risks for fetal aneuploidy. This article provides a historical overview of both invasive diagnostic testing and serum screening approaches, both biochemical and the newer molecular noninvasive prenatal testing assays, used to identify patients who would be best served by invasive testing.
authors.affiliation: *Department of Obstetrics and Gynecology/Division of Maternal-Fetal Medicine, University of Virginia, Charlottesville, Virginia; †Sequenom Inc.; ‡Department of Obstetrics and Gynecology/Division of Reproductive Medicine, University of California San Diego, San Diego, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Robinson
authors.forename: Dirk
authors.initials: D
authors.lastname: van den Boom
authors.forename: Allan T
authors.initials: AT
authors.lastname: Bombard
mesh_terms: D000649:Amniocentesis / Q000266:history / Q000379:methods*; D000782:Aneuploidy; D015193:Chorionic Villi Sampling / Q000266:history / Q000379:methods*; D004247:DNA / Q000032:analysis*; D004314:Down Syndrome / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D004247:DNA