title: Minimally invasive management of adult craniopharyngiomas: An analysis of our series and review of literature.
abstract: BACKGROUND
  Craniopharyngiomas (CPs) are slow growing tumors with an incidence of between 1.2% and 4.6%, having a bimodal age distribution typically peaking in childhood and in adults between 45 and 60 years. Recurrences occur even after documented gross total resections necessitating a combination of therapeutic strategies. Obtaining a cure of this tumor in adults without producing major side effects continues to remain elusive.
  
  
  METHODS
  We describe our results in 11 patients with CP treated in a minimally invasive fashion using a combination of techniques like burr hole aspiration, Ommaya reservoir placement, ventriculo-peritoneal (VP) shunting and focal radiation (Gamma Knife stereotactic radiosurgery/Intensity modulated radiotherapy [GKRS/IMRT]).
  
  
  RESULTS
  Visual function remained intact in all patients; endocrine status remained stable with two patients developing new postoperative diabetes insipidus. There was no periprocedural morbidity or mortality, with hospital stays for any in-patient procedure being 48 hours or less.
  
  
  CONCLUSIONS
  Minimally invasive techniques such as cyst aspiration, insertion of a catheter with Ommaya reservoir, when combined with stereotactic radiosurgery/IMRT is an effective and safe option for management and long-term control of adult CPs. We believe the Ommaya catheter by itself could act as a stent, creating a tract allowing gradual drainage of cyst fluid and stabilization without necessitating any further interventions in selected cases.
authors.affiliation: Department of Neurosurgery, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological and Taussig Cancer Institutes, Cleveland Clinic, Cleveland, Ohio, United States ; Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida.
authors.forename: Gazanfar
authors.initials: G
authors.lastname: Rahmathulla
authors.affiliation: Department of Neurosurgery, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological and Taussig Cancer Institutes, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: Gene H
authors.initials: GH
authors.lastname: Barnett
keywords: Craniopharyngioma; focal radiotherapy; minimally invasive; radiosurgery