title: Role of Notch signaling in the mammalian heart.
abstract: Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and optimize myocardial injury repair.
authors.affiliation: Nanchang University, The First Affiliated Hospital, Department of Cardiac Surgery, Donghu DistrictNanchangJiangxi, China, Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Donghu District, Nanchang, Jiangxi, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Zhou
authors.affiliation: Nanchang University, The First Affiliated Hospital, Department of Cardiac Surgery, Donghu DistrictNanchangJiangxi, China, Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Donghu District, Nanchang, Jiangxi, China.
authors.forename: J C
authors.initials: JC
authors.lastname: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D006331:Heart Diseases / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008322:Mammals; D009206:Myocardium / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051880:Receptors, Notch