title: Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin.
abstract: Hepatitis C is an inflammatory disease of the liver caused by a single-stranded RNA virus belonging to the Hepacivirus genus in the Flaviviridae family, called the hepatitis C virus. After initial infection, 70% to 85% of the patients develop chronic hepatitis C with hepatic fibrosis. In addition to specific liver changes, various extrahepatic manifestations have been associated with the hepatitis C virus infection or with medications used to treat the condition. We report the case of a patient with chronic hepatitis C who presented with the signs and symptoms of borderline tuberculoid leprosy and type 1 reaction four months after the start of treatment with a pegylated interferon/ribavirin combination.
authors.affiliation: Alfredo da Matta Foundation, ManausAM, Brazil.
authors.forename: Mônica
authors.initials: M
authors.lastname: Santos
authors.affiliation: Getúlio Vargas University Hospital, ManausAM, Brazil.
authors.forename: Emily dos Santos
authors.initials: Edos S
authors.lastname: Franco
authors.affiliation: Tropical Medicine of Amazonas Foundation, ManausAM, Brazil.
authors.forename: Paulo Luis da Costa
authors.initials: PL
authors.lastname: Ferreira
authors.affiliation: Tropical Medicine of Amazonas Foundation, ManausAM, Brazil.
authors.forename: Wornei Silva Miranda
authors.initials: WS
authors.lastname: Braga
mesh_terms: D000210:Acute-Phase Reaction / Q000139:chemically induced; D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000009:adverse effects*; D015439:Leprosy, Borderline / Q000139:chemically induced* / Q000473:pathology; D015441:Leprosy, Tuberculoid / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin; D007372:Interferons