title: Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children.
abstract: OBJECTIVE
  To assess the association of single nucleotide polymorphisms (SNPs) in five genes - leptin, leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 - with anthropometric, metabolic, and dietary parameters in a Southern Brazilian cohort of 325 children followed up from birth to 4 years old.
  
  
  METHODS
  SNPs were analyzed using polymerase chain reaction-based procedures, and their association with phenotypes was evaluated by t-test, analysis of variance, and general linear models.
  
  
  RESULTS
  LEPR223Arg allele (rs1137101) was associated with higher daily energy intake at 4 years of age (P = 0.002; Pcorrected = 0.024). PPARG 12Ala-carriers (rs1801282) presented higher glucose levels than Pro/Pro homozygotes (P = 0.007; Pcorrected = 0.042).
  
  
  CONCLUSIONS
  Two of the six studied SNPs presented consistent associations, showing that it is already possible to detect the influences of genetic variants on susceptibility to overweight in 4-year-old children.
authors.forename: Marília Remuzzi
authors.initials: MR
authors.lastname: Zandoná
authors.forename: Raquel Olmedo
authors.initials: RO
authors.lastname: Rodrigues
authors.forename: Gabriela
authors.initials: G
authors.lastname: Albiero
authors.forename: Paula Dal Bó
authors.initials: PD
authors.lastname: Campagnolo
authors.forename: Márcia Regina
authors.initials: MR
authors.lastname: Vitolo
authors.forename: Silvana
authors.initials: S
authors.lastname: Almeida
authors.forename: Vanessa Suñé
authors.initials: VS
authors.lastname: Mattevi
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D001837:Body Weights and Measures; D001938:Brazil; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002149:Energy Intake; D005247:Feeding Behavior; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007473:Ion Channels / Q000235:genetics*; D020738:Leptin / Q000235:genetics*; D016014:Linear Models; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D054411:Receptors, Leptin / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D000071256:Uncoupling Protein 1
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007473:Ion Channels; D020738:Leptin; D024101:Mitochondrial Proteins; D047495:PPAR gamma; D054411:Receptors, Leptin; D014280:Triglycerides; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1; D002784:Cholesterol