title: Adenosine 5'-triphosphate (ATP) inhibits schwann cell demyelination during Wallerian degeneration.
abstract: Adenosine 5'-triphosphate (ATP) is implicated in intercellular communication as a neurotransmitter in the peripheral nervous system. In addition, ATP is known as lysosomal exocytosis activator. In this study, we investigated the role of extracellular ATP on demyelination during Wallerian degeneration (WD) using ex vivo and in vivo nerve degeneration models. We found that extracellular ATP inhibited myelin fragmentation and axonal degradation during WD. Furthermore, metformin and chlorpromazine, lysosomal exocytosis antagonists blocked the effect of ATP on the inhibition of demyelination. Thus, these findings indicate that ATP-induced-lysosomal exocytosis may be involved in demyelination during WD.
authors.affiliation: Department of Anatomy and Neurobiology, School of Medicine, Biomedical Science Institute, Kyung Hee University, Heogi-Dong 1, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Youn Ho
authors.initials: YH
authors.lastname: Shin
authors.forename: Hyung-Joo
authors.initials: HJ
authors.lastname: Chung
authors.forename: Chan
authors.initials: C
authors.lastname: Park
authors.forename: Junyang
authors.initials: J
authors.lastname: Jung
authors.forename: Na Young
authors.initials: NY
authors.lastname: Jeong
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D012583:Schwann Cells / Q000187:drug effects* / Q000473:pathology; D014855:Wallerian Degeneration / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000255:Adenosine Triphosphate