title: Morbidity associated with treatment of chronic anal fissure.
abstract: OBJECTIVE
  To assess the effectiveness of different modes of treatment of chronic anal fissure as regards improvement of symptoms and complications.
  
  
  METHODS
  This prospective study included 129 consecutive patients with chronic anal fissures presented to the Surgical Outpatients' Department of Islam Teaching Hospital Sialkot, Pakistan; from September 2010 to November 2012. Patients were distributed in three groups. In "OBG group", patients had attended Gynae/Obs OPD and got treated and were then referred to surgical OPD for failure of treatment or recurrence. Patients who presented with history of treatment by GPs were included in "GP Group" "SGR Group" included those who directly reported to surgical OPD for treatment. Patients were managed both pharmacologically as OPD patients and surgically as admitted patients. Patients were instructed to apply small amounts of 0.2% GTN paste in soft white paraffin, to the anoderm with finger tips three times a day. Patients were evaluated at two-week intervals and at each visit the symptoms control, adverse effects and fissure status were recorded. If there was symptomatic relief or the fissure healing was in progress, the treatment was continued for a total duration of eight weeks. Operated patients were nursed in wards after surgery i.e Internal Anal Sphicterotomy. They were advised to report to OPD weekly for one month or earlier if they experienced any symptoms suggestive of complications. Patients were declared cured in case of complete symptomatic relief with fissure healing. Success, failure and associated problems were recorded and analysed to get results.
  
  
  RESULTS
  This study included 129 patients who could be followed up for a minimum of three months. These patients were referred by gynaecologist i.e. 22 (17%) for treatment failure while 5 patients with wrong diagnosis were not included in statistical analysis; similarly 41 (32%) patients were referred by general practitioners and 9 patients with wrong diagnosis were excluded. Sixty six patients i.e. 51% were those who directly reported to surgical OPD and had no previous treatment. With surgical treatment, pain, bleeding per rectum and constipation showed significant improvement as compared to GTN ointment application. Fissure healing was 100% in surgical group as compared to 74% in medical group. Complications were recorded and were found to be headache with medical treatment; while the most feared complication with surgical treatment i.e. permanent incontinence was not encountered in our study.
  
  
  CONCLUSIONS
  Topical glyceryl trinitrate is economical, has a good healing rate, and faecal incontinence has not been reported. Its effectiveness, however, depends on patients' compliance which may be poor in view of associated headaches and a local burning sensation. It is first line of treatment for anal fissure but lateral internal sphincterotomy is superior, more effective and curative than the chemical sphincterotomy. Surgery is reserved for people with anal fissure who have tried medical therapy for at least one to three months but failed.
authors.affiliation: Dr. Ansar Latif, MBBS, FCPS, Assistant Professor, Department of Surgery, Islam Medical College, Sialkot, Pakistan.
authors.forename: Ansar
authors.initials: A
authors.lastname: Latif
authors.affiliation: Dr. Anila Ansar, MBBS, MCPS, FCPS, Assistant Professor, Department of Obstetrics and Gynaecology, Islam Medical College, Sialkot, Pakistan.
authors.forename: Anila
authors.initials: A
authors.lastname: Ansar
authors.affiliation: Dr. Muhammad Qasim Butt, MBBS, FCPS, Department of Surgery, Combined Military Hospital, Kohat, Pakistan.
authors.forename: Muhammad Qasim
authors.initials: MQ
authors.lastname: Butt
keywords: Chemical sphincterotomy; Internal sphincterotomy; Pain relief; Topical glyceryl trinitrate