title: Allogeneic stem cell transplantation for chronic myeloid leukaemia is safe and effective in high risk patients following second generation tyrosine kinase inhibitors: A single centre's experience.
abstract: Most patients now receiving a haematopoietic stem cell transplant (HSCT) for chronic myeloid leukaemia (CML) have been treated with first and second line TKIs pre-HSCT, raising concerns that these patients will have more resistant disease and accumulated greater toxicity from sequential lines of therapy, potentially compromising their outcome. We outline a series of 9 patients treated with imatinib then second generation TKIs for CML followed by HSCT and compare their outcomes with patients receiving imatinib-only pre-HSCT. Our case series demonstrates that second line and sequential tyrosine kinase inhibitors followed by HSCT is a safe and effective therapeutic approach for high risk CML.
authors.affiliation: Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
authors.forename: Anne-Louise
authors.initials: AL
authors.lastname: Latif
authors.affiliation: Bone Marrow Transplant Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 OYN, UK.
authors.forename: Grant
authors.initials: G
authors.lastname: McQuaker
authors.affiliation: Bone Marrow Transplant Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 OYN, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Parker
authors.affiliation: Bone Marrow Transplant Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 OYN, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Clark
authors.affiliation: Bone Marrow Transplant Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 OYN, UK ; Paul O'Gorman Leukaemia Research Centre, College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, 21 Shelley Road, Gartnavel General Hospital, Glasgow, G12 0ZD, UK.
authors.forename: Mhairi
authors.initials: M
authors.lastname: Copland
keywords: Chronic myeloid leukaemia (CML); Haematopoietic stem cell transplant (HSCT); Tyrosine kinase inhibitor