title: Chronic functional constipation in children: adherence and factors associated with drug treatment.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the treatment adherence of children with chronic functional constipation.
  
  
  METHODS
  The present study is a prospective and longitudinal study realized at a pediatric gastroenterology clinic of a Brazilian University Hospital, between August 2009 and October 2011. Rome III criteria and the Bristol Stool Scale were used to define constipation and to characterize feces, respectively. Drug treatment was prescribed for patients according to the protocols previously standardized in the clinic. Specific questionnaires, containing questions related to 1 dependent variable and independent variables were completed in the first and sixth months of the treatment. Independent variables related to the patients, their caregivers, the disease itself, and the therapeutic plan were analyzed and compared with the dependent variable (adherence to the treatment). Adherence was considered when the patient returned with >75% of the prescribed medicine containers empty.
  
  
  RESULTS
  Fifty children participated in both the first and sixth months of treatment. The mean age of the sample was 77.6 ± 43.8 months and the mean age of the onset of symptoms was 18.8 ± 27.9 months. The adherence rate was 38% in the first month and 30% in the sixth month. Patients who were treated with polyethylene glycol had greater adherence than patients who were prescribed other laxatives, with statistical significance in the second moment of the study (P = 0.19 and P = 0.04, respectively).
  
  
  CONCLUSIONS
  The study showed low adherence rates to drug treatment of constipation in children. It is necessary to seek new strategies to increase treatment adherence, while avoiding complications and reducing costs.
authors.affiliation: Department of Pediatrics, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Sílvia A
authors.initials: SA
authors.lastname: Steiner
authors.forename: Marcia R F
authors.initials: MR
authors.lastname: Torres
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Penna
authors.forename: Barbara F
authors.initials: BF
authors.lastname: Gazzinelli
authors.forename: Caroline G A
authors.initials: CG
authors.lastname: Corradi
authors.forename: Aline S
authors.initials: AS
authors.lastname: Costa
authors.forename: Isabela G
authors.initials: IG
authors.lastname: Ribeiro
authors.forename: Eugênio G
authors.initials: EG
authors.lastname: de Andrade
authors.forename: Maria
authors.initials: M
authors.lastname: do Carmo Barros de Melo
mesh_terms: D000293:Adolescent; D000554:Ambulatory Care Facilities; D001938:Brazil; D017028:Caregivers; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003248:Constipation / Q000188:drug therapy* / Q000523:psychology; D005220:Fathers; D005243:Feces; D005260:Female; D006801:Humans; D007182:Income; D007223:Infant; D054368:Laxatives; D008137:Longitudinal Studies; D008276:Magnesium Hydroxide / Q000008:administration & dosage; D008297:Male; D009035:Mothers; D010349:Patient Compliance / Q000523:psychology; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011446:Prospective Studies; D011620:Psyllium / Q000008:administration & dosage; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D054368:Laxatives; D011092:Polyethylene Glycols; D011620:Psyllium; D008276:Magnesium Hydroxide