title: Correlation of severity of coronary artery disease with insulin resistance.
abstract: BACKGROUND
  Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail.
  
  
  OBJECTIVE
  The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus.
  
  
  METHODS
  In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score.
  
  
  RESULTS
  There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant.
  
  
  CONCLUSIONS
  The results of our study indicate that we might able to predict the severity of CAD by measure of IR.
authors.affiliation: Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Srinivasan
authors.affiliation: Department of Cardiology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Padmanabh K
authors.initials: PK
authors.lastname: Kamath
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Poornima A
authors.initials: PA
authors.lastname: Manjrekar
authors.affiliation: Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Unnikrishnan
authors.affiliation: Jr. Resident, Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Ullal
authors.affiliation: Jr. Resident, Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Mohammed Faheem
authors.initials: MF
authors.lastname: Kotekar
authors.affiliation: Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
authors.forename: Chakrapani
authors.initials: C
authors.lastname: Mahabala
keywords: Coronary artery disease; Insulin resistance; Type 2 diabetes mellitus