title: The molecular properties of nitrobenzanthrone isomers and their mutagenic activities.
abstract: The mutagenic activity of five mono-substituted nitrobenzanthrones (NBA) has been determined in the Ames assay (Takamura-Enya et al., 2006). In the present study, a theoretical investigation of the electronic properties of all mono-substituted NBA isomers and their relation to mutagenic activity are presented. Equilibrium geometries, vertical ionization potentials (VIP), vertical electron affinities (VEA), relative energies, dipole moments and electronic dipole polarizabilities, and the IR and Raman spectra of NBA isomers calculated by Density Functional Theory (DFT) methods are presented. The position of the nitro group affects the spectral features of the IR and Raman spectra of the NBA isomers. The results show that a good linear relationship exists between the summation of Raman activities (∑ARaman) over all the 3N-6 vibrational modes and the mutagenic activity of the NBA isomers in Salmonella typhimurium strains. The spectroscopic results suggest that the unknown mutagenic activities of 4-NBA, 5-NBA, 6-NBA, 8-NBA and 10-NBA are predicted to follow the order 4-NBA>10-NBA>5-NBA>8-NBA>6-NBA.
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 14-16, 11 000 Belgrade, Serbia. Electronic address: bostojic@chem.bg.ac.rs.
authors.forename: Bojana D
authors.initials: BD
authors.lastname: Ostojić
authors.affiliation: Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11 000 Belgrade, Serbia.
authors.forename: Branislav
authors.initials: B
authors.lastname: Stanković
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 14-16, 11 000 Belgrade, Serbia.
authors.forename: Dragana S
authors.initials: DS
authors.lastname: Ðorđević
mesh_terms: D001551:Benz(a)Anthracenes / Q000737:chemistry* / Q000633:toxicity*; D004583:Electrons; D007536:Isomerism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D001551:Benz(a)Anthracenes; D009153:Mutagens; C117220:3-nitrobenzanthrone
keywords: Density Functional Theory; Environmental pollutants; IR and Raman spectra; Mutagenic activity; Nitrated benzanthrones