title: Self-rated health mediates the association between functional status and health-related quality of life in Parkinson's disease.
abstract: OBJECTIVE
  To explore whether self-rated health acts as a potential mediator in the association between functional status and health-related quality of life in Parkinson's disease.
  
  
  BACKGROUND
  Older persons (as most patients with Parkinson's disease are) who reported poor self-rated health compared with those with excellent self-rated health were two-and-a-half times more likely to have experienced a decline in functional ability.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Socio-demographic and clinical data of the patients (n = 176) were obtained during a structured interview and from medical records. Functional status was measured with the Unified Parkinson's Disease Rating Scale (total score), self-rated health with the first item of the Short-Form 36-item Health Survey Questionnaire and health-related quality of life with the disease-specific questionnaire called the Parkinson's Disease Quality of Life Questionnaire-39. Multiple linear regression analyses and the Sobel test were employed to assess mediation.
  
  
  RESULTS
  Self-rated health seems to have a mediating effect on the association between functional status and health-related quality of life. The Sobel test confirmed an indirect effect of functional status via self-rated health on health-related quality of life and showed a statistically significant indirect effect of functional status on health-related quality of life via self-rated health against the direct route without the mediator.
  
  
  CONCLUSIONS
  Self-rated health partially mediates the deteriorating effect of functional status on health-related quality of life.
  
  
  CONCLUSIONS
  Supportive and adaptation psychosocial intervention programmes leading to restored self-rated health may enhance the quality of life regardless of disability in Parkinson's disease.
authors.affiliation: Graduate School Kosice Institute for Society and Health, Faculty of Medicine, Safarik University, Kosice, Slovak Republic; Institute of Public Health, Department of Social Medicine, Faculty of Medicine, Safarik University, Kosice, Slovak Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Ghorbani Saeedian
authors.forename: Iveta
authors.initials: I
authors.lastname: Nagyova
authors.forename: Daniel
authors.initials: D
authors.lastname: Klein
authors.forename: Matej
authors.initials: M
authors.lastname: Skorvanek
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Rosenberger
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Gdovinova
authors.forename: Johan W
authors.initials: JW
authors.lastname: Groothoff
authors.forename: Jitse P
authors.initials: JP
authors.lastname: van Dijk
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000451:nursing / Q000523:psychology* / Q000534:rehabilitation; D011788:Quality of Life; D012044:Regression Analysis; D011795:Surveys and Questionnaires
keywords: Parkinson's disease; functional status; health indicator; health-related quality of life; mediator; self-rated health