title: TheTGFB1 functional polymorphism rs1800469 and susceptibility to atrial fibrillation in two Chinese Han populations.
abstract: Transforming growth factor-β1 (TGF-β1) is related to the degree of atrial fibrosis and plays critical roles in the induction and perpetuation of atrial fibrillation (AF). To investigate the association of the common promoter polymorphism rs1800469 in the TGF-β1 gene (TGFB1) with the risk of AF in Chinese Han population, we carried out a case-control study of two hospital-based independent populations: Southeast Chinese population (581 patients with AF and 723 controls), and Northeast Chinese population (308 AF patients and 292 controls). Two hundred and seventy-eight cases of AF were lone AF and 334 cases of AF were diagnosed as paroxysmal AF. In both populations, AF patients had larger left atrial diameters than the controls did. The rs1800469 genotypes in the TGFB1 gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele frequencies of rs1800469 were not different between AF patients and controls of the Southeast Chinese population, Northeast Chinese population, and total Study Population. After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models. Similar results were obtained from subanalysis of the lone and paroxymal AF subgroups. Our results do not support the role of the TGFB1 rs1800469 functional gene variant in the development of AF in the Chinese Han population.
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Shenyang General Hospital, Shenyang, China.
authors.forename: Chenghui
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Fujian Provincial Hospital, Fuzhou, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Zhurong
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Donglin
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Gai
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Mingfang
authors.initials: M
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1