title: Pyoderma gangrenosum with renal and splenic impairment--case report.
abstract: Pyoderma gangrenosum is an uncommon and recurrent neutrophilic dermatosis of unknown cause. The lesions usually start as tender sterile papulopustules or erythematous nodules that undergo necrosis followed by ulceration. The lower limbs are most commonly affected and around half of the cases are associated with systemic disorders. Although rare, cases of pyoderma gangrenosum with extramucocutaneous sterile neutrophilic infiltrate have been reported, with the lungs being the most commonly affected organ. We report a case of pyoderma gangrenosum with splenic and renal impairment. Pyoderma gangrenosum should be considered a multisystemic disease with classic cutaneous manifestations and potential involvement of internal organs.
authors.affiliation: Federal University of Minas Gerais, Teaching Hospital, Dermatology Unit, Belo HorizonteMG, Brazil.
authors.forename: Luciana Rabelo de
authors.initials: LR
authors.lastname: Carvalho
authors.affiliation: Federal University of Minas Gerais, Teaching Hospital, Dermatology Unit, Belo HorizonteMG, Brazil.
authors.forename: Virgínia Vinha
authors.initials: VV
authors.lastname: Zanuncio
authors.affiliation: Federal University of Minas Gerais, Medical School, Belo HorizonteMG, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Gontijo
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000473:pathology*; D013158:Splenic Diseases / Q000150:complications / Q000473:pathology*; D055815:Young Adult