title: Methotrexate as a treatment in ocular cicatricial moderate pemphigoid.
abstract: METHODS
  A 73 year-old woman presented with a history of non-specific symptoms and photophobia in both eyes of 1 year progression. The examination revealed a bilateral symblepharon and fornix shortening. Immunohistochemical analysis confirmed the presence of linear deposits of IgG, IgM and C3 along the conjunctival basement membrane. With the diagnosis of Ocular Cicatricial Pemphigoid, systemic treatment with subcutaneous methotrexate was prescribed.
  
  
  CONCLUSIONS
  We consider such treatment a very effective initial immunosuppressive alternative in patients with moderate conjunctival inflammation and in cases of rapid progression.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España. Electronic address: anheront@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Hervás Ontiveros
authors.affiliation: Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España.
authors.forename: D
authors.initials: D
authors.lastname: Salom
authors.affiliation: Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España; Departamento de Cirugía, Unidad Docente de Oftalmología, Universidad de Valencia, Hospital Universitario La Fe, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: España Gregori
authors.affiliation: Departamento de Anatomía Patológica, Universidad de Valencia, Hospital Universitario la Fe, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: Jiménez Herrero
authors.affiliation: Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España; Departamento de Cirugía, Unidad Docente de Oftalmología, Universidad de Valencia, Hospital Universitario La Fe, Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Llopis
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003228:Conjunctiva / Q000473:pathology; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000209:etiology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007634:Keratitis / Q000209:etiology; D008727:Methotrexate / Q000627:therapeutic use*; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D008727:Methotrexate
keywords: Agentes inmunosupresores; Complicaciones cicatriz; Complications scar; Diagnosis ocular cicatricial pemphigoid; Diagnóstico penfigoide ocular cicatricial; Etiology; Etiología; Immunosuppressive agents; Methotrexate; Metotrexate; Ocular cicatricial pemphigoid; Penfigoide ocular cicatricial; Therapeutic use; Uso terapéutico