title: Working to improve survival and health for babies born very preterm: the WISH project protocol.
abstract: BACKGROUND
  Babies born very preterm (before 30 weeks gestation) are at high risk of dying in their first weeks of life, and those who survive are at risk of developing cerebral palsy in childhood. Recent high-quality evidence has shown that giving women magnesium sulphate immediately prior to very early birth can significantly increase the chances of their babies surviving free of cerebral palsy. In 2010 Australian and New Zealand clinical practice guidelines recommended this therapy. The WISH (Working to Improve Survival and Health for babies born very preterm) Project aims to bi-nationally improve and monitor the use of this therapy to reduce the risk of very preterm babies dying or having cerebral palsy.
  
  
  METHODS
  The WISH Project is a prospective cohort study. The 25 Australian and New Zealand tertiary level maternity hospitals will be provided with a package of active implementation strategies to guide the introduction and local adaptation of guideline recommendations. Surveys will be conducted at individual hospitals to evaluate outcomes related to local implementation progress and the use and value of the WISH implementation strategies. For the hospitals participating in the 'WISH audit of uptake and health outcomes data collection', the primary health outcomes (assessed through case note review, and 24 month corrected age questionnaires) will be: the proportion of eligible women receiving antenatal magnesium sulphate; and rates of death prior to primary hospital discharge and cerebral palsy at two years corrected age in infants born to eligible mothers. For hospitals wishing to assess factors influencing translation locally, barriers and facilitators will be measured through interviews with health care professionals, to further guide implementation strategies. Study outcomes for the early phase of the project (Year 1) will be compared with the later intervention phase (Years 2 and 3).
  
  
  CONCLUSIONS
  The WISH Project will offer insight into the effectiveness of a multifaceted implementation strategy to improve the uptake of a novel neuroprotective therapy in obstetric clinical practice. The successful implementation of antenatal magnesium sulphate for fetal neuroprotection in Australia and New Zealand could lead to over 90 fewer very preterm babies dying or suffering the long-term consequences of cerebral palsy each year.
authors.affiliation: Australian Research Centre for Health of Women and Babies, Robinson Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, Australia. caroline.crowther@adelaide.edu.au.
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Crowther
authors.forename: Philippa F
authors.initials: PF
authors.lastname: Middleton
authors.forename: Emily
authors.initials: E
authors.lastname: Bain
authors.forename: Pat
authors.initials: P
authors.lastname: Ashwood
authors.forename: Tanya
authors.initials: T
authors.lastname: Bubner
authors.forename: Vicki
authors.initials: V
authors.lastname: Flenady
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morris
authors.forename: Sarah
authors.initials: S
authors.lastname: McIntyre
mesh_terms: D001315:Australia / Q000453:epidemiology; D002547:Cerebral Palsy / Q000453:epidemiology / Q000517:prevention & control*; D002675:Child, Preschool; D019317:Evidence-Based Medicine; D005260:Female; D005865:Gestational Age; D019983:Guideline Adherence; D006771:Hospitals, Maternity; D006801:Humans; D007223:Infant; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology / Q000517:prevention & control*; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008485:Medical Audit; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009520:New Zealand / Q000453:epidemiology; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D047928:Premature Birth / Q000188:drug therapy* / Q000401:mortality; D011295:Prenatal Care; D011446:Prospective Studies; D012107:Research Design
chemical_list: D018696:Neuroprotective Agents; D008278:Magnesium Sulfate