title: One-pot multi-component route to propargylamines using zinc oxide under solvent-free conditions.
abstract: In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A(3)-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.
authors.forename: Mona
authors.initials: M
authors.lastname: Hosseini-Sarvari
authors.affiliation: Department of Chemistry, Faculty of Science, Shiraz University, Shiraz 71454, I.R. Iran. hossaini@susc.ac.ir.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moeini
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000737:chemistry; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D007659:Ketones; D011437:Propylamines; C009054:propargylamine; D010293:Pargyline; D015034:Zinc Oxide