title: Effects of amygdala-hippocampal stimulation on synchronization.
abstract: Changes in EEG synchronization, i.e., spatio-temporal correlation, with amygdala-hippocampal stimulation were studied in patients with temporal lobe epilepsy. Synchronization was evaluated for high frequency, 130 Hz, pseudo-monophasic or biphasic charge-balanced pulses. Desynchronization was most frequently induced by stimulation. There was no correlation between the changes in synchronization and the changes in interictal epileptiform discharge rates. Changes in synchronization do not appear yet to be a marker of stimulation efficiency in reducing seizures.
authors.affiliation: Department of Neurology, University Hospital of Geneva, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Tyrand
authors.affiliation: Department of Neurology, University Hospital of Geneva, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Seeck
authors.affiliation: Department of Neurosurgery, Inselspital, Bern, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Pollo
authors.affiliation: Department of Neurology, University Hospital of Geneva, Switzerland. Electronic address: Colette.Boex@hcuge.ch.
authors.forename: C
authors.initials: C
authors.lastname: Boëx
mesh_terms: D000679:Amygdala / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D058407:Electroencephalography Phase Synchronization / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008875:Middle Aged
keywords: DBS; Epilepsy; Temporal lobe