title: Association of ideal cardiovascular metrics and serum high-sensitivity C-reactive protein in hypertensive population.
abstract: Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk of cardiovascular disease. However, ideal cardiovascular health indicates lower risk of cardiovascular disease. This study aimed to investigate the effect of ideal cardiovascular health behaviors and health factors on hs-CRP levels among a hypertensive population. From 2006 to 2007, a cross-sectional study was conducted to survey 41,476 hypertensive subjects among the employees of Kailuan Corporation. Data from unified questionnaires and blood biochemical examinations were collected. The effects of ideal cardiovascular health behaviors and health factors on hs-CRP levels were evaluated through multivariate logistic regression analysis. A negative correlation was observed between hs-CRP levels and the number of ideal cardiovascular health metrics. The mean hs-CRP levels of subjects with zero to one, two, three, and four to six ideal cardiovascular health metrics were 1.11, 0.96, 0.90, and 0.80 mg/L, respectively (P<0.01). Multivariate logistic regression analysis revealed that after adjustment for sex, age, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and other risk factors, the risks for subjects with two, three, and four to six ideal health metrics with serum hs-CRP >3 mg/L were lower than those with zero to one ideal health metrics, with corresponding odd ratios of 0.86 (95%CI: 0.79-0.93, P<0.01), 0.76 (95%CI: 0.69-0.83, P<0.01), and 0.68 (95%CI: 0.64-0.75, P<0.01), respectively. This finding suggests that ideal cardiovascular health behaviors and health factors were related to decreased hs-CRP levels in a hypertensive population.
  
  
  BACKGROUND
  UNIQUE IDENTIFIER: ChiCTR-TNC-11001489.
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xue
authors.affiliation: Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
authors.forename: Jingsheng
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
authors.forename: Yutang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, People's Republic of China.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein