title: Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species.
abstract: Four polysaccharides from Dendrobium huoshanense (DHP), D. officinale (DOP), D. nobile (DNP) and D. chrysotoxum (DCP), which had obvious differences in intrinsic viscosities and monosaccharide compositions, were extracted to compare their hypoglycemic and antioxidative activities in alloxan-induced diabetic mice by oral administration. The analysis of fasting blood glucose, glycosylated serum protein and serum insulin levels showed that DHP, DOP and DNP, but not DCP, possessed significant hypoglycemic effect with the decreasing order of DHP>DNP>DOP. Histopathological observation confirmed the capability of DHP, DOP and DNP to intervene the damage in pancreas tissues. The determination of superoxide dismutase, catalase, malonaldehyde and L-glutathione levels in the liver and kidney displayed that DHP, DOP and DNP had protective effects against alloxan-induced oxidative damage and the effect of DHP ranked first. These results suggested that there were significant differences in hypoglycemic and antioxidative activities between four Dendrobium polysaccharides, which may be contributed to their physicochemical properties.
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Pan
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Li
authors.affiliation: The National Orchid Conservation Center of China, The Orchid Conservation and Research Center of Shenzhen, Shenzhen 518114, China.
authors.forename: Mei-Na
authors.initials: MN
authors.lastname: Wang
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Zha
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
authors.forename: Xue-Fei
authors.initials: XF
authors.lastname: Yang
authors.affiliation: The National Orchid Conservation Center of China, The Orchid Conservation and Research Center of Shenzhen, Shenzhen 518114, China. Electronic address: liuzj@sinicaorchid.org.
authors.forename: Zhong-Jian
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China.
authors.forename: Yi-Bo
authors.initials: YB
authors.lastname: Luo
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: jianpingluo@hfut.edu.cn.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Luo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D031667:Dendrobium / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014783:Viscosity
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides
keywords: Antioxidative activity; Dendrobium polysaccharides; Hypoglycemic activity