title: Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease.
abstract: OBJECTIVE
  We aimed to investigate the serum 25-hydroxyvitamin D3 (25[OH]D3 ) levels and bone metabolism in adult Chinese patients with inflammatory bowel disease (IBD) and to evaluate the correlation between vitamin D levels and the disease activity as well as the potential risk factors.
  
  
  METHODS
  Age- and gender-matched cohort of IBD patients (124 with ulcerative colitis [UC] and 107 with Crohn's disease [CD]) and 122 healthy controls were enrolled in this study. Serum levels of 25(OH)D3 and bone mineral density (BMD) were measured, and the correlation between the two parameters and the severity of the disease as well as the clinical risk factors were analyzed.
  
  
  RESULTS
  Serum 25(OH)D3 levels were lower in UC (10.32 ± 4.46 ng/mL, P < 0.001) and CD patients (11.57 ± 5.02 ng/mL, P = 0.029) than that in healthy controls (12.87 ± 4.40 ng/mL). 25(OH)D3 levels were negatively correlated with the disease severity of both UC (r = -0.371, P < 0.001) and CD (r = -0.285, P = 0.030). The incidences of osteopenia and osteoporosis were high in the IBD patients (37.9% and 3.2% in UC and 30.8% and 4.7% in CD, respectively). Cumulative quantity of glucocorticoids use was significantly associated with osteopenia and osteoporosis in both UC (odds ratio [OR] 1.219, 95% confidence interval [CI] 1.054-1.410, P = 0.008) and CD patients (OR 1.288, 95% CI 1.033-1.606, P = 0.025).
  
  
  CONCLUSIONS
  Vitamin D deficiency is likely to occur in Chinese patients with IBD and is closely associated with the severity of the disease. Glucocorticoids accumulation is a risk factor for osteopenia and osteoporosis.
authors.affiliation: Department of Gastroenterology, Key Laboratory of Chinese Health Ministry, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Tan
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Lv
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Ou
authors.initials: O
authors.lastname: Wang
authors.forename: Xiao Ping
authors.initials: XP
authors.lastname: Xing
authors.forename: Jia Ming
authors.initials: JM
authors.lastname: Qian
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D002112:Calcifediol / Q000097:blood*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D012307:Risk Factors; D012720:Severity of Illness Index; D014808:Vitamin D Deficiency / Q000150:complications; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D002112:Calcifediol
keywords: Crohn's disease; bone mineral density; inflammatory bowel disease; ulcerative colitis; vitamin D