title: The effects of anemia on pregnancy outcome in patients with pyelonephritis.
abstract: OBJECTIVE
  Pyelonephritis is a common infectious morbidity of pregnancy. Though anemia is commonly associated with pyelonephritis, there are little data describing the effect of pyelonephritis with anemia on pregnancy outcomes. The purpose of this study was to further assess the association of anemia with infectious morbidity and pregnancy complications among women with pyelonephritis.
  
  
  METHODS
  We conducted a retrospective cohort study of pregnant women admitted to Duke University Hospital between July 2006 and May 2012 with pyelonephritis. Demographic, laboratory, and clinical data from the subject's pregnancy and hospitalizations were analyzed. Patients with pyelonephritis and anemia (a hematocrit < 32) were compared to those without anemia. Descriptive statistics were used to compare the two groups.
  
  
  RESULTS
  114 pregnant women were admitted with pyelonephritis and 45 (39.5%) had anemia on admission. There was no significant difference in age, race, preexisting medical conditions, or urine bacterial species between patients with anemia and those without. Women with anemia were more likely to deliver preterm (OR 3.3 (95% CI 1.07, 11.4), P = 0.04). When controlling for race and history of preterm delivery, women with anemia continued to have increased odds of preterm birth (OR 6.0, CI 1.4, 35, P = 0.012).
  
  
  CONCLUSIONS
  Women with pyelonephritis and anemia are at increased risk for preterm delivery.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, DUMD Box 3967, Durham, NC 27710, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Dotters-Katz
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, DUMD Box 3967, Durham, NC 27710, USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Grotegut
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, DUMD Box 3967, Durham, NC 27710, USA.
authors.forename: R Phillips
authors.initials: RP
authors.lastname: Heine
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology*; D011704:Pyelonephritis / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult