title: A rare but severe complication of filgrastim in a healthy donor: splenic rupture.
abstract: BACKGROUND
  Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.
  
  
  METHODS
  In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.
  
  
  RESULTS
  She was followed conservatively. One month later the CT scan signs of rupture disappeared.
  
  
  CONCLUSIONS
  We must pay attention to this rare but serious adverse event during filgrastim use.
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey. Electronic address: adigegul@yahoo.com.
authors.forename: Gulsah
authors.initials: G
authors.lastname: Akyol
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Pala
authors.affiliation: Radiology, Erciyes University, Kayseri, Turkey.
authors.forename: Afra
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Keklika
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Demir
authors.affiliation: Internal Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Sumeyra
authors.initials: S
authors.lastname: Dortdudak
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Sivgin
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Esera
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
authors.affiliation: Erciyes Stem Cell Transplantation Center, Erciyes University, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
mesh_terms: D015746:Abdominal Pain; D000328:Adult; D001782:Blood Donors; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011994:Recombinant Proteins / Q000009:adverse effects; D013161:Splenic Rupture / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim
keywords: Filgrastim; Splenic rupture; Stem cell transplantation