title: Mucoadhesivity and release properties of quaternary ammonium-chitosan conjugates and their nanoparticulate supramolecular aggregates: an NMR investigation.
abstract: Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium-chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone loaded nanoparticles was defined by quantitative NMR and interrupted dialysis experiments, and mucoadhesivity of empty nanoparticles was effectively probed by selective relaxation rate measurements.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, Via Risorgimento 35, 56126 Pisa, Italy. Electronic address: gloria.uccello.barretta@unipi.it.
authors.forename: Gloria
authors.initials: G
authors.lastname: Uccello-Barretta
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, Via Risorgimento 35, 56126 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Balzano
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, Via Risorgimento 35, 56126 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Aiello
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, Via Risorgimento 35, 56126 Pisa, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Senatore
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Fabiano
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
authors.forename: Ylenia
authors.initials: Y
authors.lastname: Zambito
mesh_terms: D000268:Adhesiveness; D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000737:chemistry; D003956:Dialysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009077:Mucins / Q000378:metabolism; D053758:Nanoparticles; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*
chemical_list: D009077:Mucins; D000644:Quaternary Ammonium Compounds; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone; D048271:Chitosan
keywords: Chitosan conjugates; Dynamic dialysis; Interrupted dialysis; Nanoparticles; Nuclear magnetic resonance; Selective relaxation rate