title: Vitamin C supplementation does not alter high-intensity endurance training-induced mitochondrial biogenesis in rat epitrochlearis muscle.
abstract: The purpose of this study was to investigate whether vitamin C supplementation prevents high-intensity intermittent endurance training-induced mitochondrial biogenesis in the skeletal muscle. Male Wistar-strain rats were assigned to one of five groups: a control group, training group, small dose vitamin C supplemented training group, middle dose vitamin C supplemented training group, and large dose vitamin C supplemented training group. The rats of the trained groups were subjected to intense intermittent swimming training. The vitamin C supplemented groups were administrated vitamin C for the pretraining and training periods. High-intensity intermittent swimming training without vitamin C supplementation significantly increased peroxisome proliferator-activated receptor-γ coactivator-1α protein content and citrate synthase activity in the epitrochlearis muscle. The vitamin C supplementation did not alter the training-induced increase of these regardless of the dose of vitamin C supplementation. The results demonstrate that vitamin C supplementation does not prevent high-intensity intermittent training-induced mitochondrial biogenesis in the skeletal muscle.
authors.affiliation: Laboratory of Exercise Physiology, Integrated Arts and Sciences, The University of Tokushima Graduate School, 1-1 Minamijosanjima-cho, Tokushima, 770-8502, Japan, k.yada@asagi.waseda.jp.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yada
authors.forename: Hideki
authors.initials: H
authors.lastname: Matoba
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D002950:Citrate (si)-Synthase / Q000378:metabolism; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000378:metabolism; D063269:Mitochondrial Turnover / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010807:Physical Endurance; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; D014157:Transcription Factors; D019344:Lactic Acid; D002950:Citrate (si)-Synthase; D001205:Ascorbic Acid