title: Structure and function of respiratory syncytial virus surface glycoproteins.
abstract: The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of infection. G targets the ciliated cells of the airways, and F causes the virion membrane to fuse with the target cell membrane. The F protein is the major target for antiviral drug development, and both G and F glycoproteins are the antigens targeted by neutralizing antibodies induced by infection. In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.
authors.affiliation: Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: McLellan
authors.forename: William C
authors.initials: WC
authors.lastname: Ray
authors.forename: Mark E
authors.initials: ME
authors.lastname: Peeples
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002923:Cilia / Q000276:immunology / Q000821:virology; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011991:Receptors, Virus / Q000737:chemistry / Q000502:physiology; D020545:Respiratory Mucosa / Q000276:immunology / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control*; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry* / Q000187:drug effects / Q000276:immunology; D014760:Viral Fusion Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology; D014771:Virion / Q000737:chemistry / Q000502:physiology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000998:Antiviral Agents; C526850:F protein, human respiratory syncytial virus; C502275:G glycoprotein, Respiratory syncytial virus; D011991:Receptors, Virus; D022261:Respiratory Syncytial Virus Vaccines; D014760:Viral Fusion Proteins