title: Toxic effects of maternal zearalenone exposure on uterine capacity and fetal development in gestation rats.
abstract: The objectives of this study were to determine the effects of high-dose and early gestational exposure to zearalenone (ZEN) in female Sprague-Dawley (SD) rats, to correlate the maternal uterus with the fetus, and to explore the development and malformation of fetuses. Pregnant female SD rats were fed diets containing 0.3, 48.5, 97.6, or 146.0 mg/kg ZEN on gestational days (GDs) 0 through 7. All the females survived until GD 20, at which point a cesarean section was performed to harvest the organs, blood, and fetuses. The results indicated that exposure to ZEN during early gestation can impact the maternal reproductive capability. Delayed fetal development was directly linked to maternal toxicity. The toxic effects of ZEN caused early deaths more frequently than late deaths, and the deleterious effects lasted through the end of pregnancy.
authors.affiliation: 1Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jia
authors.forename: Shutong
authors.initials: S
authors.lastname: Yin
authors.forename: Anshan
authors.initials: A
authors.lastname: Shan
authors.forename: Rui
authors.initials: R
authors.lastname: Gao
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qu
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Shaoping
authors.initials: S
authors.lastname: Nie
mesh_terms: D000818:Animals; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects* / Q000473:pathology; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D004968:Estrogens, Non-Steroidal; D015025:Zearalenone
keywords: developmental toxicity; rat; teratogenesis; uterine capacity; zearalenone