title: Bioactive compounds from the roots of Asiasarum heterotropoides.
abstract: A new tetrahydrofuran lignan, (7S,8R,7'S,8'S)-3-methoxy-3',4'-methylenedioxy-7,9'-epoxylignane-4,7',9-triol (1), and 21 known compounds 2-22 were isolated from the roots of Asiasarum heterotropoides by chromatographic separation methods. The structures of all compounds 1-22 were elucidated by spectroscopic analysis including 1D- and 2D-NMR. Fourteen of these compounds (1-3, 7, 10, 12-17, 19, 21, and 22) were isolated from this species in this study for the first time. All of the isolates were evaluated for their anticancer activities using in vitro assays. Among the 22 tested compounds, two (compounds 5 and 7) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity.
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Se-Mi
authors.initials: SM
authors.lastname: Oh
authors.forename: Jin-Mu
authors.initials: JM
authors.lastname: Yi
authors.forename: No Soo
authors.initials: NS
authors.lastname: Kim
authors.affiliation: KM-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. osbang@kiom.re.kr.
authors.forename: Ok-Sun
authors.initials: OS
authors.lastname: Bang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D051858:Forkhead Transcription Factors / Q000235:genetics; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D011401:Promoter Regions, Genetic / Q000187:drug effects; D064028:Tracheophyta / Q000737:chemistry*; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D017705:Lignans; D010936:Plant Extracts; D009569:Nitric Oxide