title: Atlas of coronavirus replicase structure.
abstract: The international response to SARS-CoV has produced an outstanding number of protein structures in a very short time. This review summarizes the findings of functional and structural studies including those derived from cryoelectron microscopy, small angle X-ray scattering, NMR spectroscopy, and X-ray crystallography, and incorporates bioinformatics predictions where no structural data is available. Structures that shed light on the function and biological roles of the proteins in viral replication and pathogenesis are highlighted. The high percentage of novel protein folds identified among SARS-CoV proteins is discussed.
authors.affiliation: School of Biological Sciences, University of Reading, Reading, UK. Electronic address: b.w.neuman@reading.ac.uk.
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Neuman
authors.affiliation: School of Biological Sciences, University of Reading, Reading, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Chamberlain
authors.affiliation: School of Biological Sciences, University of Reading, Reading, UK.
authors.forename: Fern
authors.initials: F
authors.lastname: Bowden
authors.affiliation: Dart Neuroscience, San Diego, CA, USA.
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Joseph
mesh_terms: D017934:Coronavirus / Q000737:chemistry* / Q000201:enzymology* / Q000502:physiology; D020285:Cryoelectron Microscopy; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry* / Q000378:metabolism; D053838:Scattering, Small Angle
chemical_list: D009097:Multienzyme Complexes; D012324:RNA-Dependent RNA Polymerase
keywords: Cryoelectron microscopy; NMR; Nonstructural protein; Protein structure; SARS coronavirus; Small angle X-ray scattering; X-ray crystallography