title: Safety of belatacept bridging immunosuppression in hepatitis C-positive liver transplant recipients with renal dysfunction.
abstract: BACKGROUND
  Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperative risks. The authors' experience with seven liver transplant patients who received belatacept and mycophenolic acid maintenance immunosuppression is reported.
  
  
  METHODS
  A retrospective review of adult liver transplant recipients with hepatitis C receiving belatacept was conducted under Institutional Review Board approval. All patients were Epstein-Barr virus IgG seropositive. The primary endpoint was patient and graft survival, with secondary endpoints including the incidence of acute rejection, degree of renal function recovery, and occurrence of major side effects.
  
  
  RESULTS
  Between December 19, 2011 and January 25, 2013, seven liver transplant recipients with hepatitis C received belatacept immunosuppression in the perioperative period. The primary indication for belatacept was perioperative renal dysfunction. Belatacept was initiated between 2 and 90 days posttransplant and the duration of belatacept therapy ranged from 19 to 89 days. Patients were transitioned onto calcineurin inhibitor therapy when they reached chronic kidney disease stage 2 or better. Six-month patient and graft survival was 86%. There was one episode of graft rejection on belatacept therapy in a patient who had also had early rejection before initiation of belatacept.
  
  
  CONCLUSIONS
  The results in this initial group of patients suggest that belatacept with mycophenolic acid may be a safe maintenance immunosuppression regimen in hepatitis C-positive liver transplant recipients with renal dysfunction, and that this regimen can serve as an effective bridge to calcineurin inhibitor therapy.
authors.affiliation: 1 Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD. 2 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. 3 Address correspondence to: John C. LaMattina, M.D., Division of Transplantation, University of Maryland School of Medicine 29 South Greene Street, Suite 200 Baltimore, MD 21201.
authors.forename: John C
authors.initials: JC
authors.lastname: LaMattina
authors.forename: Mihaela P
authors.initials: MP
authors.lastname: Jason
authors.forename: Steven I
authors.initials: SI
authors.lastname: Hanish
authors.forename: Shane E
authors.initials: SE
authors.lastname: Ottmann
authors.forename: David K
authors.initials: DK
authors.lastname: Klassen
authors.forename: Darryn
authors.initials: D
authors.lastname: Potosky
authors.forename: William R
authors.initials: WR
authors.lastname: Hutson
authors.forename: Rolf N
authors.initials: RN
authors.lastname: Barth
mesh_terms: D000069594:Abatacept; D000368:Aged; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D018796:Immunoconjugates / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007674:Kidney Diseases / Q000503:physiopathology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D018796:Immunoconjugates; D007166:Immunosuppressive Agents; D000069594:Abatacept