title: Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.
abstract: The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity.
authors.affiliation: School of Pharmacy and Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abdul Majid
authors.initials: AM
authors.lastname: Ayatollahi
authors.affiliation: Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, I.R. Iran.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ghanadian
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Suleiman
authors.initials: S
authors.lastname: Afsharypuor
authors.affiliation: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.forename: M Ahmad
authors.initials: MA
authors.lastname: Mesaik
authors.affiliation: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Omer Mohamed
authors.initials: OM
authors.lastname: Abdalla
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Shahlaei
authors.affiliation: Welsh School of Pharmacy Centre for Socioeconomic Research, Cardiff University, UK.
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Farzandi
authors.affiliation: Welsh School of Pharmacy Centre for Socioeconomic Research, Cardiff University, UK.
authors.forename: Hamid
authors.initials: H
authors.lastname: Mostafavi
keywords: Cycloartanes; Euphorbia aellenii; Proliferation assay; Protein kinase C (PKC); Structure-activity relationship (SAR)