title: Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication.
abstract: Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address: a-yeong@hanmail.net.
authors.forename: Jeong-Yoon
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, South Korea. Electronic address: puregirl1730@hanmail.net.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, South Korea. Electronic address: yeonsunw@naver.com.
authors.forename: Yeon Sun
authors.initials: YS
authors.lastname: Woo
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address: k1000tae@naver.com.
authors.forename: Sung Un
authors.initials: SU
authors.lastname: Kim
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address: sodium75@hanmail.net.
authors.forename: Jin-Man
authors.initials: JM
authors.lastname: Jung
authors.affiliation: Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address: kwondoya@hanmail.net.
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Kwon
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology; D000998:Antiviral Agents / Q000627:therapeutic use; D004244:Dizziness; D005260:Female; D019416:Head Movements / Q000187:drug effects*; D006801:Humans; D009759:Nystagmus, Pathologic / Q000139:chemically induced*; D000069583:Pregabalin; D014202:Tremor / Q000139:chemically induced*; D014717:Vertigo; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D000998:Antiviral Agents; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000212:Acyclovir