title: Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity.
abstract: The inspection of the mechanisms through which autophagy modulates immunogenic cell death revealed that the autophagic response of cancer cells to reactive oxygen species-dependent endoplasmic reticulum stress suppresses the exposure of calreticulin on the cell surface, the phenotypic maturation of dendritic cells (DCs) as well as their ability to release interleukin-6 and to support the proliferative expansion of (interferon γ-producing) CD4+and CD8+T lymphocytes. These findings unveil an unprecedented role for therapy-induced autophagy in suppressing key mechanisms that underlie anticancer immune responses as elicited by immunogenic cell death.
authors.affiliation: Cell Death Research & Therapy (CDRT) Unit; Department for Cellular and Molecular Medicine; KU Leuven; Leuven, Belgium.
authors.forename: Abhishek D
authors.initials: AD
authors.lastname: Garg
authors.affiliation: Cell Death Research & Therapy (CDRT) Unit; Department for Cellular and Molecular Medicine; KU Leuven; Leuven, Belgium.
authors.forename: Aleksandra M
authors.initials: AM
authors.lastname: Dudek
authors.affiliation: Cell Death Research & Therapy (CDRT) Unit; Department for Cellular and Molecular Medicine; KU Leuven; Leuven, Belgium.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Agostinis
keywords: T lymphocytes; calreticulin; chaperone-mediated autophagy; damage-associated molecular patterns; dendritic cells; immunogenic cell death; photodynamic therapy; reactive oxygen species