title: Unfolding type gastroretentive film of Cinnarizine based on ethyl cellulose and hydroxypropylmethyl cellulose.
abstract: The present work was based on the development and characterization of unfolding type gastro retentive dosage form appropriate for controlled release of Cinnarizine (CNZ), a drug with narrow therapeutic window. The drug loaded polymer film of biological macromolecules, i.e., ethyl cellulose (EC) and hydroxypropylmethyl cellulose (HPMC K15) was folded into hard gelatin capsules. The film was folded in different patterns for characterizing their unfolding behavior. The polymeric film revealed a fast release during the first hour followed by a more gradual drug release during a 12-h period following a non-Fickian diffusion process. Tensile strength of polymeric film was optimized using different amount (0.2-0.7 ml) of polyethylene glycol (PEG 400). Various physical parameters were studied for evaluating their performance as a gastroretentive dosage form. Drug and polymers were found to be compatible as revealed by differential scanning calorimetry (DSC) study and scanning electron micrograph (SEM) study revealed uniform dispersion of CNZ in polymeric matrices. The results indicate that unfolding type gastro retentive drug delivery system holds lots of potential for drug having stability problems in alkaline pH or are which mainly absorbed in acidic pH.
authors.affiliation: Jan Nayak Ch. Devilal Memorial College of Pharmacy, Sirsa 125055, Haryana, India.
authors.forename: Shakuntla
authors.initials: S
authors.lastname: Verma
authors.affiliation: School of Pharmacy, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India. Electronic address: kalpana.18082@lpu.co.in.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Nagpal
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.
authors.forename: D N
authors.initials: DN
authors.lastname: Mishra
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002936:Cinnarizine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D065347:Hypromellose Derivatives; D007700:Kinetics; D055595:Mechanical Phenomena; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D002936:Cinnarizine; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose
keywords: Gastroretentive dosage form; Hydroxypropyl cellulose, Ethyl cellulose