title: The spatiotemporal organization of ErbB receptors: insights from microscopy.
abstract: Signal transduction is regulated by protein-protein interactions. In the case of the ErbB family of receptor tyrosine kinases (RTKs), the precise nature of these interactions remains a topic of debate. In this review, we describe state-of-the-art imaging techniques that are providing new details into receptor dynamics, clustering, and interactions. We present the general principles of these techniques, their limitations, and the unique observations they provide about ErbB spatiotemporal organization.
authors.affiliation: Department of Pathology and the Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico 87131.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Valley
authors.forename: Keith A
authors.initials: KA
authors.lastname: Lidke
authors.forename: Diane S
authors.initials: DS
authors.lastname: Lidke
mesh_terms: D066246:ErbB Receptors / Q000502:physiology* / Q000648:ultrastructure; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D046529:Microscopy, Electron, Transmission / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors