title: Mesoporous silica aerogel as a drug carrier for the enhancement of the sunscreen ability of benzophenone-3.
abstract: In the present study, about 45 and 34 wt% of benzophenone-3 (BP-3), an organic UV filter, was adsorbed on a high surface area mesoporous silica (MS) drug carrier to prepare BP-3-bearing MS (MSBP) sunscreen materials MSBP-1 and MSBP-2, respectively. The effect of the adsorption of BP-3 by MS on the UV protection ability of MSBP was demonstrated and a synergistic UV protection effect was observed in the as-prepared MSBP UV filters. Compared with free BP-3, adsorbed BP-3 had greatly reduced crystallinity and the dispersion of MSBP was significantly improved in the sunscreen. The in vitro sun protection factor (SPF) and in vitro UV-A values of the MSBP-2-based sunscreen was about 17.3% and 17.0% higher than that of free BP-3-based sunscreen, respectively, indicating that the ability of the sunscreen to protect against UV-B and UV-A improved because of the BP-3 content of the MS matrix. In addition, the decrease in SPF and UV-A values over time was significantly less in the MSBP-based sunscreens than in free BP-3-based sunscreen. Results of this study reveal that MS is a promising organic sunscreen carrier as well as a potential carrier for other topical drugs.
authors.affiliation: Department of Chemistry, Center for Nanotechnology and Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC; Department of Cosmetic Science, Vanung University, 1 Van-Nung Road, Chung-Li, Taoyuan County 32061, Taiwan, ROC.
authors.forename: C C
authors.initials: CC
authors.lastname: Li
authors.affiliation: Department of Chemistry, Center for Nanotechnology and Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: Y T
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Master Program of Nanotechnology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: Y T
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Center for Nanotechnology and Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: S F
authors.initials: SF
authors.lastname: Sie
authors.affiliation: Department of Chemistry, Center for Nanotechnology and Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC. Electronic address: yuiwhei@cycu.edu.tw.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chen-Yang
mesh_terms: D001577:Benzophenones / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D008859:Microscopy, Polarization; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000494:pharmacology*; D013818:Thermogravimetry; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D001577:Benzophenones; D004337:Drug Carriers; D005782:Gels; D013473:Sunscreening Agents; D012822:Silicon Dioxide; C005290:oxybenzone
keywords: Benzophenone-3; Drug release; Mesoporous silica; Sunscreen