title: Peptide conjugates for directing the morphology and assembly of 1D nanoparticle superstructures.
abstract: Designed peptide conjugates molecules are used to direct the synthesis and assembly of gold nanoparticles into complex 1D nanoparticle superstructures with various morphologies. Four peptide conjugates, each based on the gold-binding peptide (AYSSGAPPMPPF; PEPAu ), are prepared: C12H23O-AYSSGAPPMPP (1), C12H23O-AYSSGAPPMPPF (2), C12H23O-AYSSGAPPMPPFF (3), and C12H23O-AYSSGAPPMPPFFF (4). The affect that C-terminal hydrophobic F residues have on both the soft-assembly of the peptide conjugates and the resulting assembly of gold nanoparticle superstructures is examined. It is shown that the addition of two C-terminal F residues (3) leads to thick, branched 1D gold nanoparticle superstructures, whereas the addition of three C-terminal F residues (4) leads to bundling of thin 1D nanoparticle superstructures.
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260 (USA), Fax: (+01) 412-624-8611.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Chengyi
authors.initials: C
authors.lastname: Song
authors.forename: H Christopher
authors.initials: HC
authors.lastname: Fry
authors.forename: Nathaniel L
authors.initials: NL
authors.lastname: Rosi
mesh_terms: D000595:Amino Acid Sequence; D006046:Gold / Q000737:chemistry*; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology; D010455:Peptides / Q000737:chemistry*
chemical_list: D010455:Peptides; D006046:Gold
keywords: gold; nanoparticles; peptides; self-assembly; superstructures