title: Developments in the synthesis and biological activity of glycyl-L-histydyl- L-lysine derivatives.
abstract: Three decades of extensive research on biological activity of natural tripeptide Gly-His-Lys has established the substructure for development of its novel derivatives which give hope for widening the application in the field of medicine and dermatology. Synthetic approaches to obtain Gly-His-Lys and its modifications provide both classical solution method and solid phase peptide synthesis, usage of different protecting groups and methods of peptide bond formation. In our present review, we emphasize on the methods of the synthesis described in the literature and present the aspects of Gly-His-Lys structure modifications that played a key role in scientific research.
authors.forename: M
authors.initials: M
authors.lastname: Kukowska
authors.affiliation: Department of Organic Chemistry, Gdansk University of Technology, 11/12 G. Narutowicza St, 80- 233 Gdansk, Poland. m-kukowska@wp.pl.
authors.forename: K
authors.initials: K
authors.lastname: Dzierzbicka
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D011485:Protein Binding
chemical_list: D001672:Biocompatible Materials; D009842:Oligopeptides; D011108:Polymers; C020905:glycyl-histidyl-lysine