title: Nano polymeric carrier fabrication technologies for advanced antitumor therapy.
abstract: Comparing with the traditional therapeutic methods, newly developed cancer therapy based on the nanoparticulates attracted extensively interest due to its unique advantages. However, there are still some drawbacks such as the unfavorable in vivo performance for nanomedicine and undesirable tumor escape from the immunotherapy. While as we know that the in vivo performance strongly depended on the nanocarrier structural properties, thus, the big gap between in vitro and in vivo can be overcome by nanocarrier's structural tailoring by fine chemical design and microstructural tuning. In addition, this fine nanocarrier's engineering can also provide practical solution to solve the problems in traditional cancer immunotherapy. In this paper, we review the latest development in nanomedicine, cancer therapy, and nanoimmunotherapy. We then give an explanation why fine nanocanrrie's engineering with special focus on the unique pathology of tumor microenvironments and properties of immunocells can obviously promote the in vivo performance and improve the therapeutic index of nanoimmunotherapy.
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai 201203, China ; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China.
authors.forename: Mengxin
authors.initials: M
authors.lastname: Zhao
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Ke
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
authors.forename: Huafei
authors.initials: H
authors.lastname: Li
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China.
authors.forename: Fulei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai 201203, China ; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China ; Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Dai
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai 201203, China ; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China ; Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China ; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai 201203, China ; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China ; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China ; Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Guo
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D007167:Immunotherapy; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011108:Polymers