title: High rate of HIV resuppression after viral failure on first-line antiretroviral therapy in the absence of switch to second-line therapy.
abstract: In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.
authors.affiliation: Department of Infection.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Gupta
authors.forename: Ruth L
authors.initials: RL
authors.lastname: Goodall
authors.forename: Michael
authors.initials: M
authors.lastname: Ranopa
authors.forename: Cissy
authors.initials: C
authors.lastname: Kityo
authors.forename: Paula
authors.initials: P
authors.lastname: Munderi
authors.forename: Fred
authors.initials: F
authors.lastname: Lyagoba
authors.forename: Lincoln
authors.initials: L
authors.lastname: Mugarura
authors.forename: Charles F
authors.initials: CF
authors.lastname: Gilks
authors.forename: Pontiano
authors.initials: P
authors.lastname: Kaleebu
authors.forename: Deenan
authors.initials: D
authors.lastname: Pillay
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015224:Dideoxynucleosides / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000627:therapeutic use*; D019829:Nevirapine / Q000008:administration & dosage / Q000627:therapeutic use; D019562:Viral Load / Q000187:drug effects; D014766:Viremia / Q000188:drug therapy; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use*; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D004338:Drug Combinations; D019259:Lamivudine; D019829:Nevirapine; D015215:Zidovudine; D000099227:Abacavir; C109078:lamivudine, zidovudine drug combination
keywords: Africa; HIV; failure; resistance; viral resuppression