title: Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.
abstract: Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS.
authors.affiliation: Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, CHU Clermont-Ferrand Hôpital Estaing, Université d'Auvergne CREaT - EA 7283, INSERM CIC-501, Clermont-Ferrand, F-63000, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Lemal
authors.affiliation: Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, CHU Clermont-Ferrand Hôpital Estaing, Université d'Auvergne CREaT - EA 7283, INSERM CIC-501, Clermont-Ferrand, F-63000, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Chaleteix
authors.affiliation: Service d'Oncologie, CH Vichy, Vichy, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Minard
authors.affiliation: Service de Neurologie, CH Vichy, Vichy, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Roche
authors.affiliation: Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, CHU Clermont-Ferrand Hôpital Estaing, Université d'Auvergne CREaT - EA 7283, INSERM CIC-501, Clermont-Ferrand, F-63000, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
authors.affiliation: Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, CHU Clermont-Ferrand Hôpital Estaing, Université d'Auvergne CREaT - EA 7283, INSERM CIC-501, Clermont-Ferrand, F-63000, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.affiliation: Service d'Hématologie Clinique, CHU Rennes, Université Rennes 1, INSERM UMR U917, Rennes, F-35043, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lamy
keywords: LGL leukemia; Lambert–Eaton Myasthenic Syndrome; Large granular lymphocytic leukemia