title: Effect of Xeroderma pigmentosum complementation group F polymorphisms and H.pylori infection on the risk of gastric cancer.
abstract: OBJECTIVE
  We conducted a case-control study by genotyping three potential functional SNPs to assess the association of Xeroderma pigmentosum complementation group F (XPF) polymorphisms with gastric cancer susceptibility, and role of XPF polymorphisms in combination with H.pylori infection in the risk of gastric cancer.
  
  
  METHODS
  A hospital case-control study was conducted. A total of 331 patients with gastric cancer and 355 controls were collected. Three SNPs of XPF, XPF rs180067, rs1799801 and rs2276466, were genotyped by Taqman real-time PCR method with a 7900 HT sequence detector system.
  
  
  RESULTS
  The gastric cancer patients were more likely to have smoking habit, a family history of cancer and H.pylori infection. We did not find the significant difference in the genotype distributions of XPF rs180067, rs1799801 and rs2276466 between cases and controls. Multivariate logistic analysis showed a non-significant decreased risk in patients carrying rs180067 G allele, rs1799801 T allele or rs2276466 T allele genotypes. The stratification by H.pylori infection was not significantly different in polymorphisms of XPF rs180067, rs1799801 and rs2276466.
  
  
  CONCLUSIONS
  There was no evidence that polymorphisms in rs180067, rs1799801 and rs2276466 significantly affect the risk of gastric cancer. Further large sample size studies are strongly needed to validate their association.
authors.affiliation: Li-li Zhang, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: Fang Yang, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Ting-min Chang, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Ting-Min
authors.initials: TM
authors.lastname: Chang
authors.affiliation: Shu-ping Dong, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Dong
authors.affiliation: Ying-ying Fan, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Fan
authors.affiliation: Ting Lu, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lu
keywords: Gastric cancer; H.pylori; Single Nucleotide Polymorphism; Xeroderma pigmentosum complementation group F