title: Insulin sensitivity assessed by stable isotopes with oral glucose administration: validation with euglycaemic clamp.
abstract: Methods of determining insulin sensitivity that use an oral challenge of glucose are preferred to those using intravenous administration since the measurement is made in conditions more akin to normal physiology. One previously reported protocol (ODILE) studies glucose uptake in isolation from absorption and endogenous production by the intravenous administration of tracer approximately forty-five minutes after the oral dose is given. However, this methodology has not been validated against other accredited procedures. This study utilizes the euglycemic hyperinsulinemic clamp in order to validate the ODILE method.
authors.affiliation: MRC-Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, UK.
authors.forename: Leslie
authors.initials: L
authors.lastname: Bluck
authors.affiliation: Department of Paediatrics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Williams
authors.affiliation: MRC-Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Jackson
authors.affiliation: Department of Paediatrics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Burak
authors.initials: B
authors.lastname: Salgin
authors.affiliation: Department of Paediatrics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Carlo
authors.initials: C
authors.lastname: Acerini
authors.affiliation: Department of Paediatrics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: David
authors.initials: D
authors.lastname: Dunger