title: KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.
abstract: Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, KIAA1462, a gene associated with coronary artery disease, and "rokimi", encoding an untranslated spliced RNA The genetic architecture at this locus suggests that the gene product important in this association is either "rokimi", or a different isoform of KIAA1462 than the isoform that is important in cardiovascular disease. Expression data suggests that isoform f of KIAA1462 is a more attractive candidate for association with LOAD in APOE4 carriers than "rokimi" which had no detectable expression in brain.
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Deborah G
authors.initials: DG
authors.lastname: Murdock
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Bradford
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Schnetz-Boutaud
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Ping
authors.initials: P
authors.lastname: Mayo
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Allen
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Laura N
authors.initials: LN
authors.lastname: D'Aoust
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Xueying
authors.initials: X
authors.lastname: Liang
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Sabrina L
authors.initials: SL
authors.lastname: Mitchell
authors.affiliation: Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
authors.forename: Stephan
authors.initials: S
authors.lastname: Zuchner
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.affiliation: Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
authors.forename: John R
authors.initials: JR
authors.lastname: Gilbert
authors.affiliation: Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.affiliation: Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D030541:Databases, Genetic; D005091:Exons / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008126:Lod Score; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012313:RNA / Q000302:isolation & purification; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D053327:Apolipoprotein E4; D015815:Cell Adhesion Molecules; C000632511:JCAD protein, human; D012313:RNA