title: "Forgetting to remember" in Huntington's disease: a study of laboratory, semi-naturalistic, and self-perceptions of prospective memory.
abstract: Prospective memory (PM) is dependent on executive processes known to be impaired in Huntington's disease (HD); however, no study to the authors' knowledge has investigated PM in this group. We examined performance-based, semi-naturalistic, and self-reported PM in 20 individuals diagnosed with mild-moderate HD and 20 demographically similar controls. Relative to controls, HD participants demonstrated significantly lower scores in time-based PM, event-based PM (at a trend level), and the semi-naturalistic PM trial, all of which were marked by omission errors. HD participants demonstrated comparable recognition memory for the PM intentions relative to controls. HD and control participants also showed comparable scores in self-reported PM complaints. The results suggest that HD is associated with deficits in the strategic aspects of PM. HD-associated PM deficits also are evident in real-world situations, which may relate to an apparent meta-memory deficit for PM functioning as indicated by HD participants' overestimation of their PM performance on self-report.
authors.affiliation: 1 Department of Psychology, San Diego State University, San Diego, California.
authors.forename: Diane R
authors.initials: DR
authors.lastname: Nicoll
authors.affiliation: 2 Veterans Affairs, San Diego Health Care System, San Diego, California.
authors.forename: Eva
authors.initials: E
authors.lastname: Pirogovsky
authors.affiliation: 3 Department of Psychiatry, University of California San Diego, La Jolla, California.
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
authors.affiliation: 4 San Diego State University - University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Holden
authors.affiliation: 2 Veterans Affairs, San Diego Health Care System, San Diego, California.
authors.forename: J Vincent
authors.initials: JV
authors.lastname: Filoteo
authors.affiliation: 5 Department of Neuroscience, University of California San Diego, La Jolla, California.
authors.forename: Shea
authors.initials: S
authors.lastname: Gluhm
authors.affiliation: 5 Department of Neuroscience, University of California San Diego, La Jolla, California.
authors.forename: Jody
authors.initials: J
authors.lastname: Corey-Bloom
authors.affiliation: 1 Department of Psychology, San Diego State University, San Diego, California.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Gilbert
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000523:psychology*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D012649:Self Concept; D018709:Statistics, Nonparametric