title: Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study.
abstract: OBJECTIVE
  To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Academic IVF center.
  
  
  METHODS
  One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.
  
  
  METHODS
  None.
  
  
  METHODS
  Implantation, pregnancy, and spontaneous abortion rates were collected.
  
  
  RESULTS
  Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.
  
  
  CONCLUSIONS
  Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.
authors.affiliation: Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
authors.forename: Shweta
authors.initials: S
authors.lastname: Nayak
authors.affiliation: Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania; Fertility Center, York, Pennsylvania.
authors.forename: Melanie E
authors.initials: ME
authors.lastname: Ochalski
authors.affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Bo
authors.initials: B
authors.lastname: Fu
authors.affiliation: Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Kathryn-Mary
authors.initials: KM
authors.lastname: Wakim
authors.affiliation: Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
authors.forename: Tian Jao
authors.initials: TJ
authors.lastname: Chu
authors.affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Dong
authors.affiliation: Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: wakian@mail.magee.edu.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Wakim
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000639:trends; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods* / Q000639:trends; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000639:trends
chemical_list: D015415:Biomarkers; D011374:Progesterone
keywords: Progesterone level; antagonist cycle; oocyte retrieval