title: Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
abstract: We report here that when untreated mice underwent heat stress, they displayed thermoregulatory deficit (e.g., animals display hypothermia during room temperature exposure), brain (or hypothalamic) inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment (e.g., decreased plasma levels of both adrenocorticotrophic hormone and corticosterone during heat stress), multiple organ dysfunction or failure, and lethality. Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke. Our data indicate that melatonin may improve outcomes of heat stroke by reducing brain inflammation, oxidative damage, and multiple organ dysfunction.
authors.affiliation: Division of General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan ; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Tian
authors.affiliation: Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung 821, Taiwan ; Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung 821, Taiwan.
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Hsu
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
authors.forename: Mao-Tsun
authors.initials: MT
authors.lastname: Lin
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D018883:Heat Stroke / Q000503:physiopathology*; D006358:Hot Temperature; D007249:Inflammation / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D013696:Temperature; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D000324:Adrenocorticotropic Hormone; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D008550:Melatonin; D010100:Oxygen; D003345:Corticosterone