title: [Immunohistochemical expression of p53, Bcl-2, and Ki-67 proteins in traditional serrated adenomas of colon].
abstract: OBJECTIVE
  Serrated adenomas of the colon show mixed characteristics of both hyperplastic and adenomatous polyps. Serrated adenomas are known to progress via the serrated pathway than the adenoma-carcinoma pathway. The aim of this study was to evaluate the characteristics of traditional serrated adenomas compared to hyperplastic polyps and tubular adenomas by using immunohistochemical staining for p53, Bcl-2, and Ki-67.
  
  
  METHODS
  Age, sex, location, size and the immunoexpression of p53, Bcl-2, and Ki-67 were retrospectively analyzed in 20 traditional serrated adenomas, 20 hyperplastic polyps, and 20 tubular adenomas from January 2007 to December 2012 at The Catholic University of Korea, Yeouido St. Mary's Hospital.
  
  
  RESULTS
  There was no difference in Bcl-2 and p53 expression between traditional serrated adenomas and hyperplastic polyps. Ki-67 Expression of traditional serrated adenomas was higher than that of hyperplastic polyps (p=0.001). Ki-67 and p53 expression was similar between traditional serrated and tubular adenomas. Bcl-2 expression of traditional serrated adenomas was lower than that of tubular adenomas (p=0.001). Regarding the expression of p53, Bcl-2, and Ki-67 in traditional serrated adenomas, there were no statistical differences among age, sex, location, and size.
  
  
  CONCLUSIONS
  Our study suggested that Ki-67 may be helpful in distinguishing traditional serrated adenomas from hyperplastic polyps, and p53 expression may be ineffective in distinguishing between traditional serrated and tubular adenomas. From Bcl-2 expression, it is suggested that the tumorigenesis of traditional serrated adenomas is lower than that of tubular adenomas.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea.
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Jung
authors.forename: Heon Ju
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Tae Jung
authors.initials: TJ
authors.lastname: Kim
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Cho
authors.forename: Hye Kang
authors.initials: HK
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Cheung
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Jae Kwang
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D000368:Aged; D003111:Colonic Polyps / Q000503:physiopathology; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53