title: vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.
abstract: We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.
authors.affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
authors.forename: Dereje Dadi
authors.initials: DD
authors.lastname: Gudeta
authors.forename: Arshnee
authors.initials: A
authors.lastname: Moodley
authors.forename: Valeria
authors.initials: V
authors.lastname: Bortolaia
authors.forename: Luca
authors.initials: L
authors.lastname: Guardabassi
mesh_terms: D001483:Base Sequence; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial / Q000235:genetics; D006020:Glycopeptides / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D009876:Operon / Q000235:genetics / Q000502:physiology*; D011815:R Factors / Q000235:genetics / Q000502:physiology*; D016929:Rhodococcus equi / Q000235:genetics / Q000502:physiology*
chemical_list: D006020:Glycopeptides