title: Catecholamine plasma levels, IFN-γ serum levels and antibodies production induced by rabies vaccine in dogs selected for their paw preference.
abstract: To explore the possible role of the sympathetic nervous activity in the asymmetrical crosstalk between the brain and immune system, catecholamine (E, NE) plasma levels, Interferon-γ (IFN-γ) serum levels and production of antibodies induced by rabies vaccine in dogs selected for their paw preference were measured. The results showed that the direction of behavioural lateralization influenced both epinephrine levels and immune response in dogs. A different kinetic of epinephrine levels after immunization was observed in left-pawed dogs compared to both right-pawed and ambidextrous dogs. The titers of antirabies antibodies were lower in left-pawed dogs than in right-pawed and ambidextrous dogs. Similarly, the IFN-γ serum levels were lower in left-pawed dogs than in the other two groups. Taken together, these findings showed that the left-pawed group appeared to be consistently the different group stressing the fundamental role played by the sympathetic nervous system as a mechanistic basis for the crosstalk between the brain and the immune system.
authors.affiliation: a Department of Veterinary Medicine , University of Bari "Aldo Moro," Valenzano , Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Siniscalchi
authors.forename: Francesco
authors.initials: F
authors.lastname: Cirone
authors.forename: Antonio Ciro
authors.initials: AC
authors.lastname: Guaricci
authors.forename: Angelo
authors.initials: A
authors.lastname: Quaranta
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002395:Catecholamines / Q000097:blood*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D004837:Epinephrine / Q000097:blood; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005552:Forelimb / Q000502:physiology*; D007839:Functional Laterality; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology; D009483:Neuropsychological Tests; D009638:Norepinephrine / Q000097:blood; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D002395:Catecholamines; D011819:Rabies Vaccines; D007371:Interferon-gamma; D009638:Norepinephrine; D004837:Epinephrine
keywords: Catecholamines; Dog (Canis familiaris); Lateralization; Paw preference; Physiology