title: Botulinum toxin in myotonia congenita: it does not help against rigidity and pain.
abstract: Botulinum toxin (BT) is a potent local muscle relaxant with analgetic properties. Myotonia congenita (MC) is a genetic disorder producing muscle rigidity and pain. BT injected into the trapezius produced mild paresis, but no effect on rigidity and pain. There were no signs of systemic effects. Lack of BT efficacy on MC rigidity confirms its origin from muscle membrane dysfunction rather than from inappropriate neuromuscular activation. Lack of BT efficacy on pain could be caused by lack of anti-rigidity effect. It could also be due to separate non-muscular pain mechanisms unresponsive to BT.
authors.affiliation: Movement Disorders Section, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany, dressler.dirk@mh-hannover.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Dressler
authors.forename: Fereshte
authors.initials: F
authors.lastname: Adib Saberi
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000188:drug therapy* / Q000209:etiology; D009224:Myotonia Congenita / Q000150:complications / Q000188:drug therapy*; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010291:Paresis / Q000139:chemically induced; D064171:Superficial Back Muscles / Q000187:drug effects; D017211:Treatment Failure
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA