title: Digital image correlation-based optical coherence elastography.
abstract: Optical coherence elastography (OCE) provides deformation or material properties, mapping of soft tissue. We aim to develop a robust speckle tracking OCE technique with improved resolution and accuracy. A digital image correlation (DIC)-based OCE technique was developed by combining an advanced DIC algorithm with optical coherence tomography (OCT). System calibration and measurement error evaluation demonstrated that this DIC-based OCE technique had a resolution of ~0.6 μm displacement and <0.5% strain measurement in the axial scan direction. The measured displacement ranged from 0.6 to 150 μm, obtained via phantom imaging. The capability of the DIC-based OCE technique, for differentiation of stiffness, was evaluated by imaging a candle gel phantom with an irregularly shaped stiff inclusion. OCE imaging of a chicken breast sample differentiated the fat, membrane, and muscle layers. Strain elastograms of an aneurysm sample showed heterogeneity of the tissue and clear contrast between the adventitia and media. These promising results demonstrated the capability of the DIC-based OCE for the characterization of the various components of the tissue sample. Further improvement of the system will be conducted to make this OCE technique a practical tool for measuring and differentiating material properties of soft tissue.
authors.affiliation: Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto, Ontario, Canada M5B 2K3bRyerson University, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5B 2K3cUniversity of Toronto, Faculty of Medicine, Department of Medicine, Toronto, Ontario, Canada M5S1A1.
authors.forename: Cuiru
authors.initials: C
authors.lastname: Sun
authors.affiliation: Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto, Ontario, Canada M5B 2K3bRyerson University, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5B 2K3.
authors.forename: Beau
authors.initials: B
authors.lastname: Standish
authors.affiliation: Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto, Ontario, Canada M5B 2K3bRyerson University, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5B 2K3.
authors.forename: Barry
authors.initials: B
authors.lastname: Vuong
authors.affiliation: University of Toronto, Faculty of Medicine, Department of Medicine, Toronto, Ontario, Canada M5S1A1dSt. Michael's Hospital, Li Ka Shing Knowledge Institute, Keenan Research Center, Toronto, Ontario, Canada M5B 1W8.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wen
authors.affiliation: Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto, Ontario, Canada M5B 2K3bRyerson University, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5B 2K3eUniversity of Toronto, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5S1A1fSunnybrook Health Sciences Centre, Division of Neurosurgery, Toronto, Ontario, Canada M4N 3M5gUniversity of Toronto, Faculty of Medicine, Division of Neurosurgery, Toronto, Ontario, Canada M5S1A1.
authors.forename: Victor
authors.initials: V
authors.lastname: Yang
mesh_terms: D000465:Algorithms; D000818:Animals; D002645:Chickens; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*