title: Phytochemistry, Pharmacology and Toxicology of Spilanthes acmella: A Review.
abstract: Spilanthes acmella is an important medicinal plant, found in tropical and subtropical countries mainly India and South America. Popularly, it is known as toothache plant which reduces the pain associated with toothaches and can induce saliva secretion. Various extracts and active metabolites from various parts of this plant possess useful pharmacological activities. Literature survey proposed that it has multiple pharmacological actions, which include antifungal, antipyretic, local anaesthetic, bioinsecticide, anticonvulsant, antioxidant, aphrodisiac, analgesic, pancreatic lipase inhibitor, antimicrobial, antinociception, diuretic, vasorelaxant, anti-human immunodeficiency virus, toothache relieve and anti-inflammatory effects. This review is elaborately describing the traditional uses, phytochemistry, pharmacology, and toxicology of this plant. This review would assist researchers to search scientific information in the future.
authors.affiliation: Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
authors.forename: Suchita
authors.initials: S
authors.lastname: Dubey
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Maity
authors.affiliation: Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
authors.forename: Shubhini A
authors.initials: SA
authors.lastname: Saraf
authors.affiliation: Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha