title: Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide.
abstract: A novel water-soluble chitosan oligosaccharide (COS) derivative, chitosan oligosaccharide/kojic acid grafts assigned as COS/KA, was prepared by using the selective partial alkylation of N-benzylidene COS and chlorokojic acid in the presence of dimethyl sulfoxide (DMSO) and pyridine (Py). The derivative was characterized by UV-vis spectroscopy, FTIR, (1)H NMR, TGA, SEM, and XRD techniques, which showed that the alkylation reaction took place at the C-6 and C-3 positions of COS. The results showed that the degree of substitution (DS) for COS/KA was from 0.38 to 1.21, and the product exhibited an excellent solubility in organic solvents and distilled water. The antibacterial results indicated that the antibacterial activity of COS/KA was strengthened relative to COS with the increase of DS for Staphylococcus aureus , Escherichia coli , Aspergillus niger and Saccharomyces cerevisiae . These findings provide important supports for developing new antibacterial agents and expand the scope of application of COS in the food industry.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University , Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Wenshui
authors.initials: W
authors.lastname: Xia
authors.forename: Qixing
authors.initials: Q
authors.lastname: Jiang
authors.forename: Yanshun
authors.initials: Y
authors.lastname: Xu
authors.forename: Peipei
authors.initials: P
authors.lastname: Yu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D009844:Oligosaccharides; D011753:Pyrones; C011890:kojic acid; D048271:Chitosan
keywords: antimicrobial activity; chitosan oligosaccharide; kojic acid