title: Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation.
abstract: ► Nintedanib is an anti-angiogenic agent that has demonstrated activity in relapsed ovarian cancer. ► Our patient had prolonged response to nintedanib, allowing her to have potentially curative surgery 6 years after her diagnosis. ► The relationship between angiogenesis and BRCA mutation is worth exploring in ovarian cancer.
authors.affiliation: Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Han Hsi
authors.initials: HH
authors.lastname: Wong
authors.affiliation: Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Christine
authors.initials: C
authors.lastname: Parkinson
authors.affiliation: Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, University College London, 90 Tottenham Court Road, London W1T 4TJ, UK.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ledermann
authors.affiliation: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
authors.forename: James D
authors.initials: JD
authors.lastname: Brenton
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Merger
authors.affiliation: Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Ashley
authors.initials: A
authors.lastname: Shaw
authors.affiliation: Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Aileen
authors.initials: A
authors.lastname: Patterson
authors.affiliation: Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Shafi
authors.affiliation: Experimental Cancer Medicine Centre and NIHR Cambridge Biomedical Research Centre, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Earl
keywords: Angiogenesis; BIBF 1120; BRCA; Nintedanib; Ovarian cancer; VEGF