title: A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ.
abstract: Autoantibody against interferon-γ has recently been associated with a variety of opportunistic infections, particularly among Asians. We report the case of a 64-year-old Japanese woman who suffered from concomitant or sequential infections of the skin, lungs, bronchi, uterus, and bladder with nontuberculous mycobacteriosis, cerebellar toxoplasmosis, measles,herpes zoster, and vulvar herpes. Blood mononuclear cells from the patient displayed intact cytokine production in response to various stimuli and interferon-γ. High-titer anti-interferon-γ autoantibodies were detected in her serum. The atypical pathology hampered early diagnosis, but indeterminate results of an interferon-γ release assay could offer a simple clue suggesting the presence of autoantibody.
authors.affiliation: Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine. etsuro@aichi-med-u.ac.jp.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohbayashi
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Yokoi
mesh_terms: D001323:Autoantibodies / Q000097:blood; D006801:Humans; D007371:Interferon-gamma; D059425:Interferon-gamma Release Tests; D009165:Mycobacterium Infections, Nontuberculous; D014123:Toxoplasmosis
chemical_list: D001323:Autoantibodies; D007371:Interferon-gamma