title: Antibodies in autoimmune thyroiditis affect glucose metabolism of anterior cingulate.
abstract: BACKGROUND
  Hypothyroidism induced by an autoimmune process is associated with neuropsychiatric symptoms and metabolic abnormalities in the brain. The aim of this study was to examine the relationship between autoimmune thyroiditis and regional brain function in hypothyroid patients.
  
  
  METHODS
  Cerebral glucose metabolism, as an index of brain function, was assessed in regional whole-brain analyses using positron emission tomography (PET) and [18F]fluorodeoxyglucose in thirteen hypothyroid patients with autoimmune thyroiditis suffering from neuropsychiatric symptoms. The primary biological measures were radioactivity in pre-selected brain regions, relative to whole-brain radioactivity, as a surrogate index of glucose metabolism, and serum levels of thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies as endocrine markers of autoimmune thyroiditis.
  
  
  RESULTS
  Serum levels of anti-TG antibodies in hypothyroid patients were significantly correlated with glucose metabolism in the perigenual anterior cingulate cortex, a brain region previously shown to regulate affect and emotional homeostasis.
  
  
  CONCLUSIONS
  Thyroid autoimmune processes may play an important role in the still poorly defined pathogenic correlates of disturbed function in brain regions critically involved in emotional processing in hypothyroid conditions.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pilhatsch
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schlagenhauf
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Silverman
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Berman
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: E D
authors.initials: ED
authors.lastname: London
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Martinez
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: P C
authors.initials: PC
authors.lastname: Whybrow
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: Michael.bauer@uniklinikum-dresden.de.
authors.forename: M
authors.initials: M
authors.lastname: Bauer
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology* / Q000378:metabolism*
chemical_list: D000906:Antibodies; D019788:Fluorodeoxyglucose F18
keywords: Autoimmunity; Brain activity; Hypothyroidism; Neuropsychiatry; PET; Thyroid antibodies; Thyroiditis