title: Early and intermediate prognosis of intravenous thrombolytic therapy in acute ischemic stroke subtypes according to the causative classification of stroke system.
abstract: OBJECTIVE
  Intravenous thrombolytic therapy has established acceptable results in treating ischemic stroke. However, there is little information on treatment outcome especially in different subtypes. The aim of current study was to evaluate early and intermediate prognosis in intravenous thrombolytic therapy for acute ischemic stroke subtypes.
  
  
  METHODS
  Forty eligible patients (57.5% male with mean age of 63.18±13.49 years) with definite ischemic stroke who were admitted to emergency department of Imam Reza University Hospital, in the first 180 minutes after occurrence received recombinant tissue plasminogen activator. All investigation findings were recorded and stroke subtypes were determined according to the Causative Classification of Stroke System. Stroke severity forms including modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) scores were recorded for all patients in first, seven and 90 days after stroke and disease outcome was evaluated.
  
  
  RESULTS
  The etiology of stroke was large artery atherosclerosis in 20%, cardio-aortic embolism in 45%, small artery occlusion in 17.5% and undetermined causes in 17.5%. NIHSS and mRS scores were significantly improved during time (P < 0.001 in both cases). Three months mortality rate was 25%. Among the etiologies, patients with small artery occlusion and then cardio-aortic embolism had lower NIHSS score at arrival (P = 0.04). Caplan-meier analysis showed that age, sex and symptom to needle time could predict disease outcome.
  
  
  CONCLUSIONS
  Intravenous thrombolytic therapy is accompanied by good early and intermediate outcome in most patients with ischemic stroke. Small artery occlusion subtype had less disease severity and higher improvement.
authors.affiliation: Ali Pashapour, Associate Professor, Departments of Neurology, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Pashapour
authors.affiliation: Abolfazl Atalu, Resident of Neurology, Neurosciences Research Center, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Atalu
authors.affiliation: Mehdi Farhoudi, Associate Professor, Neuroscience Research Center, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoudi
authors.affiliation: Ali-Akbar Taheraghdam, Assistant Professor, Departments of Neurology, Resident of Neurology, Neurosciences Research Center, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali-Akbar
authors.initials: AA
authors.lastname: Taheraghdam
authors.affiliation: Elyar Sadeghi Hokmabadi, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Elyar
authors.initials: E
authors.lastname: Sadeghi Hokmabadi
authors.affiliation: Ehsan Sharifipour, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Sharifipour
authors.affiliation: Mehdi NajafiNeshli, Resident of Neurology, Neurosciences Research Center, Imam Reza Teaching Hospital, School of Medicine,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Najafineshli
keywords: Etiology; Ischemic Stroke Subtypes; Ischemic stroke; Outcome; Thrombolytic therapy