title: Human growth hormone induced cholestatic hepatitis in a growth hormone deficient patient with short stature.
abstract: METHODS
  We report a patient with growth hormone deficiency that developed cholestatic hepatitis during treatment with recombinant human growth hormone (HGH). The patient developed jaundice and pruritus during treatment with growth hormone. She did not use any other medications. Her jaundice and pruritus were disappeared and liver enzyme disturbances were normalized after HGH discontinuation.
  
  
  CONCLUSIONS
  Clinician should be aware of this potential adverse drug reaction and frequent checking of liver enzymes is recommended in patients treating with HGH.
authors.forename: Mozhghan
authors.initials: M
authors.lastname: Zahmatkeshan
authors.forename: Zohre
authors.initials: Z
authors.lastname: Karamizadeh
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Department of Internal Medicine, Namazi hospital, Shiraz University of Medical Sciences, Shiraz, Iran. eshraghiana@yahoo.com.
authors.forename: Ahad
authors.initials: A
authors.lastname: Eshraghian
mesh_terms: D001827:Body Height; D001921:Brain / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000172:deficiency*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D041781:Jaundice, Obstructive / Q000139:chemically induced* / Q000473:pathology*; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D011537:Pruritus / Q000139:chemically induced; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I