title: Use of neostigmine in capecitabine-induced paralytic ileus.
abstract: Paralytic ileus is a recognised side effect of the oral agent capecitabine. We present this report on a patient with metastatic colorectal cancer who was treated with capecitabine and presented with persistent paralytic ileus which did not respond to standard conservative measures. Neostigmine was administered safely, resulting in resolution of the paralytic ileus. This approach merits further investigation.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mak
authors.forename: Robyn
authors.initials: R
authors.lastname: Ward
authors.forename: Yahya
authors.initials: Y
authors.lastname: Shehabi
authors.forename: Ramya
authors.initials: R
authors.lastname: Venkateswaran
authors.forename: Melvin
authors.initials: M
authors.lastname: Chin
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000069287:Capecitabine; D002277:Carcinoma / Q000188:drug therapy; D002430:Cecal Neoplasms / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D009388:Neostigmine / Q000627:therapeutic use*; D010277:Parasympathomimetics / Q000627:therapeutic use*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D010277:Parasympathomimetics; D003841:Deoxycytidine; D009388:Neostigmine; D000069287:Capecitabine; D005472:Fluorouracil