title: Developing novel blood-based biomarkers for Alzheimer's disease.
abstract: Alzheimer's disease is the public health crisis of the 21st century. There is a clear need for a widely available, inexpensive and reliable method to diagnosis Alzheimer's disease in the earliest stages, track disease progression, and accelerate clinical development of new therapeutics. One avenue of research being explored is blood based biomarkers. In April 2012, the Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened top scientists from around the world to discuss the state of blood based biomarker development. This manuscript summarizes the meeting and the resultant discussion, including potential next steps to move this area of research forward.
authors.affiliation: Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Snyder
authors.affiliation: Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Inc., Boston, MA, USA.
authors.forename: Francine
authors.initials: F
authors.lastname: Grodstein
authors.affiliation: Biomarker and Research Division, Nordic Biosciences, Copenhagen, Denmark.
authors.forename: Kim
authors.initials: K
authors.lastname: Henriksen
authors.affiliation: NextGen Sciences Dx, Gainesville, FL, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Jeromin
authors.affiliation: Institute of Psychiatry, Department of Medicine and Neurosciences, King's College, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Mielke
authors.affiliation: Internal Medicine Department, University of North Texas Health Sciences Center at Fort Worth, Fort Worth, TX, USA.
authors.forename: Sid
authors.initials: S
authors.lastname: O'Bryant
authors.affiliation: Araclon Biotech, Zaragoza, Spain.
authors.forename: Manual
authors.initials: M
authors.lastname: Sarasa
authors.affiliation: Diagenic ASA, Oslo, Norway.
authors.forename: Magnus
authors.initials: M
authors.lastname: Sjøgren
authors.affiliation: Bristol Myers Squibb, Co., Wallingford, CT, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Soares
authors.affiliation: University of Southampton, Southampton, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Teeling
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Trushina
authors.affiliation: Proteome Sciences plc, London, UK.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Ward
authors.affiliation: C2N Diagnostics, St Louis, MO, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: West
authors.affiliation: Independent Science Writer, Philadelphia, PA, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Bain
authors.affiliation: Alzheimer's Drug Discovery Foundation, New York, NY, USA.
authors.forename: Diana W
authors.initials: DW
authors.lastname: Shineman
authors.affiliation: School of Medicine, University of California-San Francisco, San Francisco, CA, USA; Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Weiner
authors.affiliation: Alzheimer's Drug Discovery Foundation, New York, NY, USA.
authors.forename: Howard M
authors.initials: HM
authors.lastname: Fillit
mesh_terms: D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D018450:Disease Progression; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: Alzheimer's disease; Biomarker; Blood based biomarker; Diagnostics; Early detection; Early diagnosis