title: [CDK3 expression and its clinical significance in human nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression profile and the clinical significance of CDK3 in the tissues of nasopharyngeal carcinoma.
  
  
  METHODS
  Immunohistochemistry was utilized to detect the expression of CDK3 in 94 cases of NPC and 40 cases of nasopharyngeal inflammation.
  
  
  RESULTS
  CDK3 was highly expressed in NPC cell lines. Immunohistochemistry showed that CDK3 was mostly expressed in the cytoplasm. The positive expression rate of NPC was 67% and that of nasopharyngeal inflammation was only 12. 5%. The difference between these two groups was highly statistically significant. The CDK3 expression in NPC was related to the TNM clinical staging of NPC (P < 0.01).
  
  
  CONCLUSIONS
  The expression levels of CDK3 were obviously higher in NPC tissues. The CDK3 expression in NPC was related to the TNM clinical staging of NPC. It suggests that CDK3 expression may play an important role in the occurrence and development of nasopharyngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Beijing University Shenzhen Hospital, Shenzhen, 518036, China.
authors.forename: Hongyi
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Otolaryngology, Beijing University Shenzhen Hospital, Shenzhen, 518036, China.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Otolaryngology, Beijing University Shenzhen Hospital, Shenzhen, 518036, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.affiliation: Shenzhen University Medical College, China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Shenzhen University Medical College, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Beijing University Shenzhen Hospital, Shenzhen, 518036, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Nie
authors.affiliation: Shenzhen University Medical College, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Zheng
mesh_terms: D000328:Adult; D002277:Carcinoma; D056849:Cyclin-Dependent Kinase 3 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging
chemical_list: C098776:CDK3 protein, human; D056849:Cyclin-Dependent Kinase 3