title: Sphingosine 1-phosphate signalling.
abstract: Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Mendelson
authors.forename: Todd
authors.initials: T
authors.lastname: Evans
authors.forename: Timothy
authors.initials: T
authors.lastname: Hla
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005121:Extremities / Q000196:embryology; D006321:Heart / Q000196:embryology; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*; D015398:Signal Transduction; D013109:Sphingomyelins / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; D013109:Sphingomyelins; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: S1P receptors; Sphingomyelin; Sphingosine-1-phosphate