title: Clinical efficacy and safety of transcatheter closure of ruptured sinus of valsalva aneurysm.
abstract: OBJECTIVE
  To evaluate the clinical efficacy and safety of transcatheter closure (TCC) in patients with ruptured sinus of Valsalva aneurysm (RSVA).
  
  
  BACKGROUND
  RSVA is a rare cardiovascular disease with a varied clinical presentation. The clinical efficacy and safety of TCC for RSVA still remain an ongoing concern.
  
  
  METHODS
  From January 2009 to March 2013, 22 patients with RSVA were selected for TCC. Intracardiac pressure and size of cardiac chamber were measured before and post TCC. All patients were followed up by transthoracic echocardiography at 1, 3, 6, 12 months after procedure.
  
  
  RESULTS
  RSVA was successfully occluded in 20 patients (19 cases with Amplatzer duct occluder and one with muscular ventricular septal defect occluder). Aortic root angiography showed no shunt in 18 cases and a small residual shunt in two cases. The pressures in the right atrium, right ventricle, and pulmonary artery were significantly decreased after the procedure (P < 0.01), and the aortic pressure was elevated (P < 0.001). The internal diameters of the right atrium, left atrium, and left ventricle were also significantly declined after the procedure (P < 0.05). No complications were found after 18.5 ± 6.5 (range 3-35) months follow-up. Two patients underwent acute surgical aortic valve replacement because of procedure-related aortic valve regurgitation.
  
  
  CONCLUSIONS
  Our results indicate that TCC is a promising alternative therapy to surgery in appropriate patients with RSVA. However, rare but severe procedure-related complications should be considered in the risk assessment.
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Tong
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Yao
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Li
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D001019:Aortic Rupture / Q000000981:diagnostic imaging / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055989:Septal Occluder Device; D012850:Sinus of Valsalva / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Amplatzer duct occluder; aortic valve regurgitation; sinus of Valsalva aneurysm; transcatheter closure