title: Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.
abstract: In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r(2) =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.
authors.affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Kar
authors.affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.
authors.forename: Snehamayee
authors.initials: S
authors.lastname: Mohapatra
authors.affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.
authors.forename: Satyabrata
authors.initials: S
authors.lastname: Bhanja
authors.affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.
authors.forename: Debjyoti
authors.initials: D
authors.lastname: Das
authors.affiliation: UDPS, Utkal University, Vani Vihar, Bhubaneswar, India.
authors.forename: Bhaktibhusan
authors.initials: B
authors.lastname: Barik
keywords: Isosorbide; Matrix tablet; Release rate; Sustained release; Xanthan gum