title: Immunization with a thermostable newcastle disease virus K148/08 strain originated from wild mallard duck confers protection against lethal viscerotropic velogenic newcastle disease virus infection in chickens.
abstract: Newcastle disease (ND) is one of the most devastating poultry infections because of its worldwide distribution and accompanying economical threat. In the present study, we characterized the ND virus (NDV) K148/08 strain from wild mallard duck, with regard to safety, thermostability, immunogenicity, and protective efficacy against velogenic ND viral infection. The NDV K148/08 strain offered enhanced immunogenicity and safety relative to commercially available vaccine strains. The NDV K148/08 strain was safe in 1-day-old SPF chicks after vaccination using a coarse or cabinet-type fine sprayer. We demonstrated that the NDV K148/08 strain elicited high levels of antibody responses and provided protective efficacy against lethal NDV challenge. In addition, the thermostability of the NDV K148/08 strain was as high as that of the thermostable V4 strain. Therefore, the NDV K148/08 strain may be useful to ensure NDV vaccine performance and effectiveness in developing countries, especially in remote areas without cold chains.
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Jeong
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Byoung-Yoon
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Soo-Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000821:virology*; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology* / Q000821:virology; D004372:Ducks / Q000821:virology*; D005243:Feces / Q000821:virology; D007114:Immunization / Q000009:adverse effects / Q000662:veterinary*; D009521:Newcastle Disease / Q000276:immunology / Q000401:mortality / Q000517:prevention & control* / Q000821:virology; D009522:Newcastle disease virus / Q000276:immunology*; D010802:Phylogeny; D013696:Temperature; D016896:Treatment Outcome; D062690:Vaccines, Live, Unattenuated / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use
chemical_list: D062690:Vaccines, Live, Unattenuated; D014765:Viral Vaccines