title: Safety, efficacy, and predictability of laser in situ keratomileusis to correct myopia or myopic astigmatism with a 750 Hz scanning-spot laser system.
abstract: OBJECTIVE
  To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) to correct myopia or myopic astigmatism using the Amaris 750S 750 Hz excimer laser.
  
  
  METHODS
  Private LASIK center, Tokyo, Japan.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Patients with myopia or myopic astigmatism (spherical equivalent -0.50 to -11.63 diopters [D]), a corrected distance visual acuity (CDVA) of 20/20 or better, and an estimated residual bed thickness of 300 μm or more had LASIK using the aspheric aberration-free ablation profile of the 750 Hz scanning-spot laser and the Femto LDV Crystal Line femtosecond laser for flap creation. Study parameters included uncorrected distance visual acuity (UDVA), CDVA, manifest refraction, astigmatism, and higher-order aberrations (HOAs).
  
  
  RESULTS
  The study included 1280 eyes (685 patients). At 3 months, 96.6% of eyes had a UDVA of 20/20 or better and 99.1% had 20/32 or better; 94.1% of eyes were within ± 0.50 D of the intended correction and 98.9% were within ± 1.00 D; 89.7% of eyes had no residual cylinder and 96.0% had a postoperative astigmatism of less than 0.50 D. All eyes had a postoperative CDVA of 20/20 or better. The HOAs increased postoperatively (P<.001), with mean total postoperative corneal and ocular HOAs of 0.66 μm ± 0.20 (SD) and 0.56 ± 0.23 μm, respectively. The efficacy index and safety index were 1.02 and 1.06, respectively.
  
  
  CONCLUSIONS
  Laser in situ keratomileusis with the 750 Hz scanning-spot laser was safe, effective, and predictable. No specific clinical side effects that might be associated with a high repetition rate occurred.
  
  
  BACKGROUND
  Mr. Magnago is an employee of Schwind eye-tech-solutions GmbH. No other author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany. Electronic address: tomita@shinagawa-lasik.com.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tomita
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Watabe
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yukawa
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: From Shinagawa LASIK Center (Tomita, Watabe, Yukawa, N. Nakamura, T. Nakamura), Chiyoda-ku, Tokyo, Japan; Wenzhou University (Tomita), Wenzhou, China; Schwind eye-tech-solutions GmbH (Magnano), Kleinostheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Magnago
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery*; D003315:Cornea / Q000503:physiopathology; D057108:Corneal Wavefront Aberration / Q000503:physiopathology; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects / Q000379:methods*; D054018:Lasers, Excimer / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult