title: Resistin gene variations are associated with the metabolic syndrome in Japanese men.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  Metabolic syndrome is defined as a cluster of risk factors for cardiovascular disease and is intimately related to insulin resistance. Resistin, a hormone secreted by adipocytes, may play an important role in communication between adiposity and insulin resistance. We investigated whether variations in the resistin gene associated with metabolic syndrome in a Japanese population.
  
  
  METHODS
  We analyzed five SNPs, two of which were located in the promoter region (-420C > G, -358G > A), two in intron 2 (+157C > T, +299G > A), and one in the 3'-untranslated region (3'UTR) (+1263G > C) across the resistin gene in 2968 residents from an urban Japanese cohort. The associations of SNPs and haplotypes with metabolic syndrome were analyzed.
  
  
  RESULTS
  The GAC and CGC haplotypes (comprising -420C > G, -358G > A, and +157C > T) had opposite influences on metabolic syndrome susceptibility in men; the former was associated with an increased risk and the latter with a decreased risk. We also found that the -420G allele was significantly associated with an increased risk of metabolic syndrome and significantly correlated with high diastolic blood pressure, high HOMA-IR values, high serum triglyceride levels, low HDL-cholesterol levels and high serum levels of adiponectin.
  
  
  CONCLUSIONS
  We identified a risk-conferring SNP and haplotype of the resistin gene for metabolic syndrome in a Japanese population. Our data suggested that resistin gene is a susceptibility gene for metabolic syndrome in Japanese men.
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan. Electronic address:miyamoty@hsp.ncvc.go.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyamoto
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Morisaki
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kokubo
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Yamanaka
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Hitonobu
authors.initials: H
authors.lastname: Tomoike
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Yoshimasa
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morisaki