title: Xuebijing Protects Rats from Sepsis Challenged with Acinetobacter baumannii by Promoting Annexin A1 Expression and Inhibiting Proinflammatory Cytokines Secretion.
abstract: Xuebijing (XBJ) injection is a herbal medicine that has been widely used in the treatment of sepsis in China; however, its role in the development and progression of Acinetobacter baumannii sepsis and the underlying mechanisms remain uninvestigated. In the present study, fifty-four male Wistar rats were randomly assigned to normal-control group, sepsis-control group, and sepsis + XBJ group, each containing three subgroups of different treatment time periods (6, 12, and 24 hrs following injection, resp.). The sepsis model was established by intraperitoneal injection of A. baumannii ATCC 19606. For XBJ treatment, 4 mL/kg XBJ was administrated simultaneously by intravenous injection through caudal vein every 12 hrs. All animals demonstrated ill state, obvious intestinal dysfunction, histopathological lung damages, and overactive inflammatory responses after A. baumannii infection, and these events could be partially reversed by XBJ treatment from the beginning of infection. XBJ induced an increase in the expression of anti-inflammatory mediator annexin A1; however, two proinflammatory cytokines, interleukin-8 (IL-8) and tumor necrosis factor- α (TNF- α ), were decreased at the each monitored time point. These findings suggested that XBJ via its cytokine-mediated anti-inflammatory effects might have a potential role in preventing the progression of A. baumannii infection to sepsis by early administration.
authors.affiliation: Department of Intensive Care, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
authors.forename: Xian-Di
authors.initials: XD
authors.lastname: He
authors.affiliation: Department of Nursing, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Intensive Care, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
authors.forename: Hua-Xue
authors.initials: HX
authors.lastname: Wang
authors.affiliation: Department of Intensive Care, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
authors.forename: Rong-Sheng
authors.initials: RS
authors.lastname: Zheng
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
authors.forename: Zi-Shu
authors.initials: ZS
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
authors.forename: Jun-Bin
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang