title: Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis.
abstract: Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase and increases to 40-70% in advanced disease. Progression of CML from chronic phase to accelerated phase or blast crisis is often associated with secondary chromosomal aberrations. We report an exceptional case of CML as debut in lymphoblastic blast crisis and a subsequent progression in myeloblastic blast crisis with rare cytogenetic abnormalities.
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Calderón-Cabrera
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Montero
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Morales
authors.affiliation: UGC Genética, Reproducción y Medicina Fetal. Hospital Universitario Virgen del Rocío.
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carrillo
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Caballero-Velázquez
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Prats
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Bernal
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: De Blas
authors.affiliation: UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez-Simón
keywords: Blast crisis; Chronic myeloid leukemia; Cytogenetic abnormalities