title: Association of TSH concentrations and thyroid autoimmunity with IVF outcome in women with TSH concentrations within normal adult range.
abstract: OBJECTIVE
  This study aimed to evaluate the association of thyroid-stimulating hormone (TSH) concentrations and presence of thyroid autoimmunity (TAI) with the live birth rate in euthyroid women undergoing in vitro fertilization (IVF).
  
  
  METHODS
  This study of retrospective design included 158 euthyroid women (TSH 0.5-4.5 µIU/ml) who underwent IVF from January 2006 to December 2010. Thyroid parameters were measured on day 3 of the previous nontreatment cycle. Women were subgrouped and analyzed according to their TSH concentrations (low: 0.5-2.5 vs. high: 2.6-4.5 µIU/ml) and TAI (present vs. absent).
  
  
  RESULTS
  No difference in the live birth rate was found between the TSH (low: 34.2% vs. high: 36.8%, p = 0.763) or TAI (present: 26.7% vs. absent: 34.3%, p = 0.568) subgroups.
  
  
  CONCLUSIONS
  This study found no evidence that increased TSH concentrations or the presence of TAI determined before IVF affect the live birth rate in euthyroid women. A better insight into the role of thyroid function during application of IVF is needed.
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Gesthimani
authors.initials: G
authors.lastname: Mintziori
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Goulis
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Gialamas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Dosopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Zouzoulas
authors.forename: George
authors.initials: G
authors.lastname: Gitas
authors.forename: Christos A
authors.initials: CA
authors.lastname: Venetis
authors.forename: Konstantinos A
authors.initials: KA
authors.lastname: Toulis
authors.forename: Efstratios M
authors.initials: EM
authors.lastname: Kolibianakis
authors.forename: Basil C
authors.initials: BC
authors.lastname: Tarlatzis
mesh_terms: D000328:Adult; D015551:Autoimmunity / Q000276:immunology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D050498:Live Birth; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000276:immunology / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D013972:Thyrotropin