title: Synthesis of nucleotide-amino acid conjugates designed for photo-CIDNP experiments by a phosphotriester approach.
abstract: Conjugates of 2'-deoxyguanosine, L-tryptophan and benzophenone designed to study pathways of fast radical reactions by the photo Chemically Induced Dynamic Nuclear Polarization (photo-CIDNP) method were obtained by the phosphotriester block liquid phase synthesis. The phosphotriester approach to the oligonucleotide synthesis was shown to be a versatile and economic strategy for preparing the required amount of high quality samples of nucleotide-amino acid conjugates.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia ; Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia.
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Abramova
authors.affiliation: Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia ; International Tomography Center, SB RAS, Institutskaya 3a, Novosibirsk 630090, Russia.
authors.forename: Olga B
authors.initials: OB
authors.lastname: Morozova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Silnikov
authors.affiliation: Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia ; International Tomography Center, SB RAS, Institutskaya 3a, Novosibirsk 630090, Russia.
authors.forename: Alexandra V
authors.initials: AV
authors.lastname: Yurkovskaya
keywords: CIDNP; nucleotide–amino acid conjugates; oligonucleotide synthesis; phosphotriester approach