title: Metabolic thrift and the genetic basis of human obesity.
abstract: Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust into our modern "obesogenic" environment, creates the current obesity crisis. Modern genetic analysis has identified genetic and epigenetic contributors to obesity, an understanding of which will guide the development of environmental, pharmacologic, and genetic therapeutic interventions.
authors.affiliation: From the Department of Surgery, University of Michigan and Ann Arbor VA Hospital, Ann Arbor, MI.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Oʼrourke
mesh_terms: D000273:Adipose Tissue / Q000502:physiology; D001069:Appetite Regulation; D005075:Biological Evolution; D015415:Biomarkers / Q000378:metabolism; D002980:Climate; D004734:Energy Metabolism; D004777:Environment; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020738:Leptin / Q000378:metabolism; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D015415:Biomarkers; D020738:Leptin