title: [Synthesis and bioactivities of novel dihydroartemisinin-piperazine derivatives containing sulfonamide].
abstract: Dihydroartemisinin is an important derivative of artemisinin. We used dihydroartemisinin as the starting material, through esterification, amination and acylation, a series of novel piperazine-sulfonamide contained dihydroartemisinin derivatives were firstly synthesized and their chemical structures were confirmed by IR, 1H NMR, 13C NMR and HR-MS. X-diffraction was used to determine the final configuration of the compound 3c. And the in vitro anti-HeLa activities of compounds 3 were analyzed with CCK-8 method. The preliminary bioassay test shows that compound 3 showed the best inhibition activities against HeLa with IC50 values of 0.14 micromol x L(-1).
authors.affiliation: School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
authors.forename: Xue-qiang
authors.initials: XQ
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
authors.forename: Cou-xi
authors.initials: CX
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; D010879:Piperazines; D013449:Sulfonamides; D000077489:Piperazine; C039060:artenimol