title: Association of CILP2 and ACE gene polymorphisms with cardiovascular risk factors in Slovak midlife women.
abstract: The aim of this study is to assess the association of two polymorphisms, the cartilage intermediate layer protein 2 (CILP2) G/T and angiotensin converting enzyme (ACE) I/D, with blood pressure and anthropometrical and biochemical parameters related to the development of cardiovascular disease. The entire study sample comprised 341 women ranging in age from 39 to 65 years. The CILP2 genotypes were determined by PCR-RFLP and the ACE genotypes by PCR. The Bonferroni pairwise comparisons showed the effect of the CILP2 genotype on high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), apoB-to-apoA1 ratio, the total cholesterol (TC)-to-HDL-C ratio, non-HDL-C, and the LDL-C-to-HDL-C ratio (P < 0.05). Here, higher mean levels of HDL-C and lower mean levels of the remaining above mentioned lipid parameters were registered in the GT/TT genotype carriers than in GG carriers. Statistically significant association was identified between the ACE genotype and the following parameters: TC, LDL-C, and non-HDL-C (P < 0.05). The II genotype can lower serum level of TC (B = 0.40), LDL-C (B = 0.37), and non-HDL-C levels. The results of this study suggest that the minor T allele of CILP2 gene and I allele of ACE gene have a protective effect against elevated serum lipid and lipoprotein levels.
authors.affiliation: Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska Dolina, 842 15 Bratislava, Slovakia.
authors.forename: Lenka
authors.initials: L
authors.lastname: Luptáková
authors.affiliation: Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska Dolina, 842 15 Bratislava, Slovakia.
authors.forename: Dominika
authors.initials: D
authors.lastname: Benčová
authors.affiliation: Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska Dolina, 842 15 Bratislava, Slovakia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Siváková
authors.affiliation: Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska Dolina, 842 15 Bratislava, Slovakia.
authors.forename: Marta
authors.initials: M
authors.lastname: Cvíčelová
mesh_terms: D000483:Alleles; D001794:Blood Pressure / Q000235:genetics; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood / Q000235:genetics; D008074:Lipoproteins / Q000097:blood / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D018154:Slovakia
chemical_list: D008055:Lipids; D008074:Lipoproteins; D008869:Microtubule-Associated Proteins; C109878:cytoplasmic linker protein 115; D002784:Cholesterol; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A