title: Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels.
abstract: OBJECTIVE
  To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.
  
  
  METHODS
  Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.
  
  
  RESULTS
  DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).
  
  
  CONCLUSIONS
  ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Hou
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Miao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Qiao-Xiang
authors.initials: QX
authors.lastname: Yin
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
authors.affiliation: The cadre ward of General Hospital of the Air Force PLA, No, 30, Fucheng Road, Haidian District, Beijing 100142, China. luohuilan998@163.com.
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: Luo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000473:pathology; D000075222:Essential Hypertension; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A