title: A "ship in a bottle" strategy to load a hydrophilic anticancer drug in porous metal organic framework nanoparticles: efficient encapsulation, matrix stabilization, and photodelivery.
abstract: An essential challenge in the development of nanosized metal organic framework (nanoMOF) materials in biomedicine is to develop a strategy to stabilize their supramolecular structure in biological media while being able to control drug encapsulation and release. We have developed a method to efficiently encapsulate topotecan (TPT, 1), an important cytotoxic drug, in biodegradable nanoMOFs. Once inside the pores, 1 monomers aggregate in a "ship in a bottle" fashion, thus filling practically all of the nanoMOFs' available free volume and stabilizing their crystalline supramolecular structures. Highly efficient results have been found with the human pancreatic cell line PANC1, in contrast with free 1. We also demonstrate that one- and two-photon light irradiation emerges as a highly promising strategy to promote stimuli-dependent 1 release from the nanoMOFs, hence opening new standpoints for further developments in triggered drug delivery.
authors.affiliation: Departamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica, and INAMOL, Universidad de Castilla-La Mancha , Avenida Carlos III, S/N, 45071 Toledo, Spain.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: di Nunzio
authors.forename: Valentina
authors.initials: V
authors.lastname: Agostoni
authors.forename: Boiko
authors.initials: B
authors.lastname: Cohen
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
authors.forename: Abderrazzak
authors.initials: A
authors.lastname: Douhal
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry*; D004339:Drug Compounding; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D017785:Photons; D016062:Porosity; D019772:Topotecan / Q000008:administration & dosage / Q000737:chemistry*; D014233:Tricarboxylic Acids / Q000737:chemistry; D000090324:Tumor Protein, Translationally-Controlled 1
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005290:Ferric Compounds; D014233:Tricarboxylic Acids; D000090324:Tumor Protein, Translationally-Controlled 1; D019772:Topotecan; C069849:trimesic acid