title: The crystallization of monosodium urate.
abstract: Gout is a common crystal-induced arthritis, in which monosodium urate (MSU) crystals precipitate within joints and soft tissues and elicit an inflammatory response. The causes of elevated serum urate and the inflammatory pathways activated by MSU crystals have been well studied, but less is known about the processes leading to crystal formation and growth. Uric acid, the final product of purine metabolism, is a weak acid that circulates as the deprotonated urate anion under physiologic conditions, and combines with sodium ions to form MSU. MSU crystals are known to have a triclinic structure, in which stacked sheets of purine rings form the needle-shaped crystals that are observed microscopically. Exposed, charged crystal surfaces are thought to allow for interaction with phospholipid membranes and serum factors, playing a role in the crystal-mediated inflammatory response. While hyperuricemia is a clear risk factor for gout, local factors have been hypothesized to play a role in crystal formation, such as temperature, pH, mechanical stress, cartilage components, and other synovial and serum factors. Interestingly, several studies suggest that MSU crystals may drive the generation of crystal-specific antibodies that facilitate future MSU crystallization. Here, we review MSU crystal biology, including a discussion of crystal structure, effector function, and factors thought to play a role in crystal formation. We also briefly compare MSU biology to that of uric acid stones causing nephrolithasis, and consider the potential treatment implications of MSU crystal biology.
authors.affiliation: Divisions of Rheumatology, Department of Medicine, NYU School of Medicine, New York, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Martillo
authors.forename: Lama
authors.initials: L
authors.lastname: Nazzal
authors.forename: Daria B
authors.initials: DB
authors.lastname: Crittenden
mesh_terms: D002358:Cartilage, Articular / Q000378:metabolism; D002627:Chemistry, Physical; D003460:Crystallization; D006073:Gout / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D033461:Hyperuricemia / Q000378:metabolism; D056724:Immunity, Humoral; D007669:Kidney Calculi / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism; D014527:Uric Acid / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
chemical_list: D014527:Uric Acid