title: Bilateral renal artery stenosis in a patient with chronic myeloid leukemia treated with nilotinib.
abstract: Previously authors have recently described an association between nilotinib therapy for chronic myeloid leukemia (CML) and severe peripheral artery disease, coronary artery disease and sudden death. We present a case report of a male patient with CML who received nilotinib therapy. He developed bilateral renal artery stenosis and renovascular hypertension. He had no history of hypertension, cardiovascular disease, or diabetes, and he was a nonsmoker. Together, these observations indicated that obtaining further understanding of the effects is necessary and that extreme caution is warranted when considering second-generation tyrosine kinase inhibitors for first-line therapy in CML.
authors.affiliation: Department of Internal Medicine, Viborg Regional Hospital, Viborg, Denmark.
authors.forename: Tilde
authors.initials: T
authors.lastname: Kristensen
authors.affiliation: Department of Internal Medicine, Viborg Regional Hospital, Viborg, Denmark.
authors.forename: Else
authors.initials: E
authors.lastname: Randers
authors.affiliation: Department of Hematology, University Hospital Aarhus, Aarhus, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Stentoft
keywords: Leukemia; Renal artery stenosis; Renovascular hypertension; Tyrosine kinase inhibitor