title: A comparison of small-field tissue phantom ratio data generation methods for an Elekta Agility 6 MV photon beam.
abstract: Tissue-phantom ratios (TPRs) are a common dosimetric quantity used to describe the change in dose with depth in tissue. These can be challenging and time consuming to measure. The conversion of percentage depth dose (PDD) data using standard formulae is widely employed as an alternative method in generating TPR. However, the applicability of these formulae for small fields has been questioned in the literature. Functional representation has also been proposed for small-field TPR production. This article compares measured TPR data for small 6 MV photon fields against that generated by conversion of PDD using standard formulae to assess the efficacy of the conversion data. By functionally fitting the measured TPR data for square fields greater than 4cm in length, the TPR curves for smaller fields are generated and compared with measurements. TPRs and PDDs were measured in a water tank for a range of square field sizes. The PDDs were converted to TPRs using standard formulae. TPRs for fields of 4 × 4cm(2) and larger were used to create functional fits. The parameterization coefficients were used to construct extrapolated TPR curves for 1 × 1 cm(2), 2 × 2-cm(2), and 3 × 3-cm(2) fields. The TPR data generated using standard formulae were in excellent agreement with direct TPR measurements. The TPR data for 1 × 1-cm(2), 2 × 2-cm(2), and 3 × 3-cm(2) fields created by extrapolation of the larger field functional fits gave inaccurate initial results. The corresponding mean differences for the 3 fields were 4.0%, 2.0%, and 0.9%. Generation of TPR data using a standard PDD-conversion methodology has been shown to give good agreement with our directly measured data for small fields. However, extrapolation of TPR data using the functional fit to fields of 4 × 4cm(2) or larger resulted in generation of TPR curves that did not compare well with the measured data.
authors.affiliation: Medical Physics Department, The James Cook University Hospital, Middlesbrough, United Kingdom. Electronic address: neil.richmond@stees.nhs.uk.
authors.forename: Neil
authors.initials: N
authors.lastname: Richmond
authors.affiliation: Medical Physics Department, The James Cook University Hospital, Middlesbrough, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Brackenridge
mesh_terms: D032701:Biomimetics / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D017785:Photons / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011882:Radiotherapy, High-Energy / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Dosimetry; Radiotherapy