title: Recycling metchnikoff: probiotics, the intestinal microbiome and the quest for long life.
abstract: Over a century ago, Elie Metchnikoff theorized that health could be enhanced and senility delayed by manipulating the intestinal microbiome with host-friendly bacteria found in yogurt. His theory flourished for a time, then drifted to the fringe of medical practice before re-emerging in the mid-1990s as a concept worthy of mainstream medical attention. Metchnikoff also predicted the existence of bacterial translocation and anticipated theories linking chronic inflammation with the pathogenesis of atherosclerosis and other disorders of the aged.
authors.affiliation: Medical Care Clinical Center, VA Maryland Health Care System , Baltimore, MD , USA ; Department of Medicine, University of Maryland School of Medicine , Baltimore, MD , USA.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Mackowiak
keywords: Lactobacilli; Metchnikoff; microbiome; phagocytes; senility