title: Acral pseudolymphomatous angiokeratoma: case report and literature review.
abstract: The authors describe a case of a female patient with Acral Pseudolymphomatous Angiokeratoma of Children, known as APACHE. It is a rare benign cutaneous disease, of unknown etiology, characterized by multiple, asymptomatic erythematous-violaceous papules and nodules, usually located unilaterally with acral distribution. Today, this denomination is questionable, since there are published reports of this disease in adults and in different locations. Clinically, it is similar to an angiokeratoma, whereas hystologically, it corresponds to a distinct type of pseudolymphoma. The immunohistochemical study is required to distinguish APACHE from cutaneous lymphoma.
authors.affiliation: University of Taubaté, University Hospital of Taubaté, Dermatology Service, TaubatéSP, Brazil.
authors.forename: Priscila Pacheco
authors.initials: PP
authors.lastname: Lessa
authors.affiliation: University of Taubaté, University Hospital of Taubaté, Dermatology Service, TaubatéSP, Brazil.
authors.forename: Juliana Chaib Ferreira
authors.initials: JC
authors.lastname: Jorge
authors.affiliation: Federal University of São Paulo, Paulista Medical School.
authors.forename: Flávia Regina
authors.initials: FR
authors.lastname: Ferreira
authors.affiliation: University of Taubaté, Medical Sciences department, TaubatéSP, Brazil.
authors.forename: Marcia Lanzoni de Alvarenga
authors.initials: ML
authors.lastname: Lira
authors.affiliation: University of Taubaté, University Hospital of Taubaté, Medical Sciences department, TaubatéSP, Brazil.
authors.forename: Samuel Henrique
authors.initials: SH
authors.lastname: Mandelbaum
mesh_terms: D000794:Angiokeratoma / Q000473:pathology*; D001706:Biopsy; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019310:Pseudolymphoma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*