title: In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies.
abstract: This study was performed to obtain prolonged drug release with biodegradable in situ forming implants for the local delivery of metronidazole to periodontal pockets. The effect of polymer type (capped and uncapped PLGA), solvent type (water-miscible and water-immiscible) and the polymer/drug ratio on in vitro drug release studies were investigated. In situ implants with sustained metronidazole release and low initial burst consisted of capped PLGA and N-methyl-2-pyrolidone as solvent. Mucoadhesive polymers were incorporated into the in situ implants in order to modify the properties of the delivery systems towards longer residence times in vivo. Addition of the polymers changed the adhesiveness and increased the viscosity and drug release of the formulations. However, sustained drug release over 10 days was achievable. Biodegradable in situ forming implants are therefore an attractive delivery system to achieve prolonged release of metronidazole at periodontal therapy.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University , Tandoğan, Ankara , Turkey and.
authors.forename: Muge
authors.initials: M
authors.lastname: Kilicarslan
authors.forename: Martin
authors.initials: M
authors.lastname: Koerber
authors.forename: Roland
authors.initials: R
authors.lastname: Bodmeier
mesh_terms: D020341:Absorbable Implants; D000268:Adhesiveness; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004343:Drug Implants; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008795:Metronidazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000378:metabolism; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012997:Solvents; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D012997:Solvents; D008795:Metronidazole; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid