title: A developmental program drives aggressive embryonal brain tumors.
abstract: Embryonal tumors with multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants. A new study shows that these tumors are universally driven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest human microRNA cluster, activating a fetal neural development program.
authors.affiliation: Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Tenley C
authors.initials: TC
authors.lastname: Archer
authors.affiliation: Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Pomeroy
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D000097584:DNA Methyltransferase 3B
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D008565:Membrane Proteins; D035683:MicroRNAs; D000097584:DNA Methyltransferase 3B; C417913:TTYH1 protein, human