title: Interaction of stable colloidal nanoparticles with cellular membranes.
abstract: Due to their ultra-small size, inorganic nanoparticles (NPs) have distinct properties compared to the bulk form. The unique characteristics of NPs are broadly exploited in biomedical sciences in order to develop various methods of targeted drug delivery, novel biosensors and new therapeutic pathways. However, relatively little is known in the negotiation of NPs with complex biological environments. Cell membranes (CMs) in eukaryotes have dynamic structures, which is a key property for cellular responses to NPs. In this review, we discuss the current knowledge of various interactions between advanced types of NPs and CMs.
authors.affiliation: Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Meng
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China.
authors.forename: Xing Jie
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, CA 95616, USA.
authors.forename: Masoud
authors.initials: M
authors.lastname: Rahman
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Pfeiffer
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany.
authors.forename: Raimo
authors.initials: R
authors.lastname: Hartmann
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany.
authors.forename: Pilar Rivera
authors.initials: PR
authors.lastname: Gil
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pelaz
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany; CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Spain.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany; CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Del Pino
authors.affiliation: Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany; Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Andalusian Technological Park, C/Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Carregal-Romero
authors.affiliation: Institute for Life Sciences, Physics and Astronomy, Faculty of Physical and Applied Sciences, University of Southampton, Highfield, Southampton SO17, 1BJ, United Kingdom.
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Kanaras
authors.affiliation: A*STAR Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore; National University of Singapore, Division of Bioengineering, Faculty of Engineering, 7 Engineering Drive 1, Singapore 117576, Singapore. Electronic address: subramaniant@imre.a-star.edu.sg.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Tamil Selvan
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001812:Blood-Brain Barrier; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D022082:Cellular Structures / Q000378:metabolism; D003102:Colloids / Q000737:chemistry*; D016503:Drug Delivery Systems; D005334:Fever; D015316:Genetic Therapy; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry; D013499:Surface Properties
chemical_list: D003102:Colloids; D011506:Proteins
keywords: Cell membrane; Colloid; Nanoparticle; Protein corona; Receptor; Targeted delivery