title: Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.
abstract: Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA ; Hines Veterans Affairs Medical Center, Hines, IL, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Rana
authors.affiliation: Hines Veterans Affairs Medical Center, Hines, IL, USA ; Division of Gastroenterology, Department of Medicine, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Basabi
authors.initials: B
authors.lastname: Rana
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA ; Centre for Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ranchi, India.
authors.forename: Rajakishore
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Sondarva
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA ; Department of Veterinary Parasitology, Veterinary College and Research Institute, Namakkal, India.
authors.forename: Velusamy
authors.initials: V
authors.lastname: Rangasamy
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Subhasis
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Navin
authors.initials: N
authors.lastname: Viswakarma
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: Anumantha
authors.initials: A
authors.lastname: Kanthasamy
keywords: JNK; MAPKs; MLKs; cancer; phosphorylation