title: Prevalence of vitamin D deficiency in HIV-positive, antiretroviral treatment-naïve patients in a single centre study.
abstract: The objective of this study was to describe the prevalence of vitamin D deficiency among antiretroviral treatment-naïve, HIV-positive individuals. We reviewed records of consecutive antiretroviral treatment-naïve patients, registering for care for the first time at a London clinic from 01 January 2008 to 31 December 2009. During this period, serum 25-hydroxycholecalciferol was measured routinely for all new patients. 25-hydroxycholecalciferol deficiency and severe deficiency were defined as ≤50 and ≤25 nmol/L, respectively. Among 253 patients (82% men, median age 36 years, 64% white ethnicity), 148 (58.5%) were 25-hydroxycholecalciferol-deficient, including 32 (12.6%) who were severely deficient. In all, 73.5% (61/83) patients of non-white ethnicity were 25-hydroxycholecalciferol-deficient compared with 50.7% (76/150) of those reporting white ethnicity (p < 0.001). Seven of eight (87.5%) patients with hypocalcaemia (<2.12 nmol/L) were 25-hydroxycholecalciferol-deficient. The prevalence of 25-hydroxycholecalciferol-deficiency was higher in winter and spring vs. summer and autumn (89/129 [69.0%] vs. 59/124 [47.6%],p < 0.001). Serum 25-hydroxycholecalciferol deficiency was not associated with gender, CD4 count, HIV viral load or clinical stage. Serum 25-hydroxycholecalciferol deficiency was common among antiretroviral treatment-naïve patients, with those of non-white ethnicity at highest risk. CD4 count, HIV viral load and HIV clinical staging do not help to identify those at risk, but low serum calcium should prompt investigation of 25-hydroxycholecalciferol levels.
authors.affiliation: Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK keertigedela@doctors.org.uk.
authors.forename: Keerti
authors.initials: K
authors.lastname: Gedela
authors.affiliation: Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK.
authors.forename: Simon G
authors.initials: SG
authors.lastname: Edwards
authors.affiliation: Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Benn
authors.affiliation: Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK.
authors.forename: Alison D
authors.initials: AD
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D019562:Viral Load; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxycholecalciferol; AIDS; HIV; antiretroviral therapy; bone metabolism; hypocalcaemia; hypovitaminosis; vitamin D deficiency