title: Subjective quality of life in At-Risk Mental State for psychosis patients: relationship with symptom severity and functional impairment.
abstract: OBJECTIVE
  The understanding of factors related to poor subjective quality of life (sQoL) in early psychosis patients is important for both research and treatment efforts. This study examined how sQoL is associated with age at onset of prodromal symptoms, duration of untreated illness (DUI), symptom severity, premorbid functioning and current functional impairment in At-Risk Mental State (ARMS) for psychosis patients.
  
  
  METHODS
  Forty ARMS patients were assessed for sQoL, symptom severity, premorbid functioning, and social and role functioning.
  
  
  RESULTS
  As expected, a large number of significant and negative correlations between sQoL domains and several symptom dimensions emerged, especially for negative symptoms, behavioural change and depression. Poor premorbid functioning in late adolescence was associated with impairments in the psychological health and social relationship domains of sQoL. Current functional impairment was associated with all sQoL domains. Neither age at onset of prodromal symptoms nor DUI was related with sQoL.
  
  
  CONCLUSIONS
  Findings indicate that different domains of sQoL are differentially and meaningfully associated with symptom severity and functional impairment, suggesting that greater symptom severity and poor functioning are already related with decreased sQoL in the ARMS for psychosis stage. Furthermore, findings highlight the importance of examining functional impairment and affective-motivational symptoms in future research on sQoL in ARMS populations due to their strong relationship with poor sQoL. Finally, findings underscore the importance of addressing the social and occupational dysfunctions already present in early psychosis with psychosocial interventions.
authors.affiliation: Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Tecelli
authors.initials: T
authors.lastname: Domínguez-Martínez
authors.affiliation: Department of Psychology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kwapil
authors.affiliation: Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.|Departament de Salut Mental, Sant Pere Claver- Fundació Sanitària, Barcelona, Spain.|Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.|Department of Psychology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
authors.forename: Neus
authors.initials: N
authors.lastname: Barrantes-Vidal
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D005260:Female; D006801:Humans; D008297:Male; D062706:Prodromal Symptoms; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D012917:Social Adjustment; D055815:Young Adult
keywords: early psychosis; functioning; premorbid adjustment; schizophrenia; subjective quality of life