title: Sensitisation of ovarian cancer cells to cisplatin by flavonoids from Scutellaria barbata.
abstract: Combination of natural components with anticancer drugs is a new strategy for cancer chemotherapy to increase antitumour responses. In this study, we investigated the sensitisation effects of nine flavonoids from Scutellaria barbata to cisplatin (CDDP) on human ovarian cancer cells. The combinations of three flavonoids with CDDP showed the synergistic effects. The intracellular reactive oxygen species and the antioxidant activity were measured. The data suggest that the synergistic effects of flavonoids with CDDP on ovarian cancer cells did not directly correlate with their redox properties, but could be associated with the positions of hydroxyl group and methoxy group of flavonoids.
authors.affiliation: a Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Jia-Chuan
authors.initials: JC
authors.lastname: Lei
authors.forename: Yang
authors.initials: Y
authors.lastname: Hao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Yang
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010851:Picrates / Q000494:pharmacology; D031363:Scutellaria / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D002945:Cisplatin
keywords: Scutellaria barbata; antioxidant; cisplatin; flavonoids; ovarian cancer