title: RETRACTED: Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  At the request of the University of Wyoming, this article has been retracted. Although an investigation report from Air Force Medical University found no evidence of misconduct, the University of Wyoming’s institutional investigation of the work authored by Dr. Jun Ren found evidence of data irregularities in Figures 2, 3, and 4 that affect the reported results and conclusions. All authors have been notified of the retraction of this article.
authors.affiliation: Department of Cardiology, Xijing Hospital, China; Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA. Electronic address: zhangym197951@126.com.
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA; Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Han
authors.affiliation: Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.
authors.forename: Anna F
authors.initials: AF
authors.lastname: Huff
authors.affiliation: Department of Cardiology, Xijing Hospital, China; Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Xijing Hospital, China; Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA. Electronic address: jren@uwyo.edu.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D000071189:Autophagy-Related Protein-1 Homolog; D002118:Calcium / Q000378:metabolism; D031204:Caloric Restriction; D006321:Heart / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000172:deficiency* / Q000235:genetics*; D011897:Random Allocation; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: C546843:mTOR protein, mouse; C494922:Akt2 protein, mouse; D000071189:Autophagy-Related Protein-1 Homolog; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C112444:Ulk1 protein, mouse; D002118:Calcium
keywords: AMPK; Akt2; Autophagy; Caloric restriction; Myocardial; mTOR