title: Respiratory stroke volume variation assessed by oesophageal Doppler monitoring predicts fluid responsiveness during laparoscopy.
abstract: BACKGROUND
  This study was designed to assess the ability of the stroke volume respiratory variation (ΔrespSV) determined by oesophageal Doppler monitoring (ODM) to predict the response to volume expansion (VE) during pneumoperitoneum. The predictive value of ΔrespSV was evaluated according to the concept of the 'grey zone'.
  
  
  METHODS
  Patients operated on laparoscopy and monitored by ODM were prospectively included. The exclusion criteria were frequent ectopic beats or preoperative arrhythmia, right ventricular failure, and spontaneous breathing. Haemodynamic parameters and oesophageal Doppler indices [stroke volume (SV), peak velocity (PV), cardiac output (CO), corrected flow time (FTc), respiratory variation of PV (ΔrespPV) and SV (ΔrespSV)] were collected before and after VE. Responders were defined as a ≥15% increase in SV after VE.
  
  
  RESULTS
  Thirty-eight (64%) of the 59 patients were responders. A cut-off of >14% ΔrespSV predicted fluid responsiveness with an area under the ROC curve (AUC) of 0.92 [95% confidence interval (CI): 0.82-0.98, P<0.0001]. The grey zone of ΔrespSV ranged between 13 and 15%. With an AUC of 0.71 (95% CI: 0.56-0.83, P=0.005), ΔrespPV fairly accurately predicted fluid responsiveness. FTc was unable to accurately predict fluid responsiveness.
  
  
  CONCLUSIONS
  ΔrespSV and ΔrespPV predicted fluid responsiveness during laparoscopy under strict physiological conditions. FTc was not predictive of fluid responsiveness during laparoscopy.
authors.affiliation: Anaesthesiology and Critical Care Department, Amiens University Hospital, Place Victor Pauchet, Amiens 80054, France.
authors.forename: P-G
authors.initials: PG
authors.lastname: Guinot
authors.forename: B
authors.initials: B
authors.lastname: de Broca
authors.forename: E
authors.initials: E
authors.lastname: Bernard
authors.forename: O
authors.initials: O
authors.lastname: Abou Arab
authors.forename: E
authors.initials: E
authors.lastname: Lorne
authors.forename: H
authors.initials: H
authors.lastname: Dupont
mesh_terms: D000328:Adult; D000368:Aged; D015150:Echocardiography, Doppler / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D011028:Pneumoperitoneum, Artificial; D011237:Predictive Value of Tests; D015656:Respiratory Mechanics / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology*; D055815:Young Adult
keywords: Doppler, intraoperative; anaesthesia; laparoscopy; monitoring; stroke volume