title: Pancreatic anastomosis leak 15 years after simultaneous pancreas-kidney transplantation from late-onset allograft cytomegalovirus duodenal ulcers presenting with gross hematuria.
abstract: Cytomegalovirus (CMV) infection is one of the most important causes of morbidity and mortality in solid organ transplantation. It can present with hematuria, the most common urological complication in the early post-simultaneous pancreas-kidney (SPK) transplant period. In SPK transplantation, CMV infection usually occurs 1 month after transplantation. We report an instance of bladder-drained SPK transplant presenting with recurrent gross hematuria from CMV infected duodenal graft ulcers 15 years after preserved well-functioning grafts. Serum quantitative Polymerase Chain Reaction (qPCR) for CMV was negative. Postmortem duodenal graft staining for CMV was positive, and revealed the cause of the inciting ulcer. To our knowledge, our patient is the first reported case of very late onset invasive CMV disease causing duodenal graft ulcers 15 years after transplantation, as previously reported cases of posttransplant CMV disease occurred only as late as 18 months. In addition, the absence of correlation between CMV viremia and CMV-infected duodenal allograft in SPK transplant has not been reported. Our case demonstrates that CMV viral load is -unreliable to diagnose invasive CMV disease, and tissue biopsy should be obtained to avoid missed diagnosis causing high morbidity and mortality.
authors.affiliation: Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T.).
authors.forename: Ekamol
authors.initials: E
authors.lastname: Tantisattamo
authors.affiliation: Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T.).
authors.forename: Roland C K
authors.initials: RC
authors.lastname: Ng
authors.affiliation: Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T.).
authors.forename: Heath
authors.initials: H
authors.lastname: Chung
authors.affiliation: Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T.).
authors.forename: Manami
authors.initials: M
authors.lastname: Okado
mesh_terms: D000368:Aged; D057868:Anastomotic Leak / Q000821:virology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis*; D004381:Duodenal Ulcer / Q000821:virology*; D017809:Fatal Outcome; D006417:Hematuria / Q000821:virology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000821:virology*; D013997:Time Factors
keywords: cytomegalovirus infection; duodenal graft ulcers; hematuria; pancreas-kidney transplantation; pancreatic anastomosis leak