title: Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments.
abstract: BACKGROUND
  Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity.
  
  
  METHODS
  The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements.
  
  
  RESULTS
  The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics.
  
  
  CONCLUSIONS
  It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis.
authors.forename: Juan
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Engineering Mechanics, Nanling Campus, Jilin University, No, 5988 Renmin Street, Changchun 130025, People's Republic of China. gonghe@jlu.edu.cn.
authors.forename: He
authors.initials: H
authors.lastname: Gong
authors.forename: Lingyan
authors.initials: L
authors.lastname: Kong
authors.forename: Dong
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee; D015519:Bone Density; D001862:Bone Resorption / Q000503:physiopathology; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D055595:Mechanical Phenomena; D010003:Osteoarthritis / Q000503:physiopathology; D011474:Prosthesis Design; D013977:Tibia / Q000502:physiology / Q000503:physiopathology