title: Depression and kidney transplantation.
abstract: While kidney transplantation offers several advantages in terms of improved clinical outcomes and quality of life compared to dialysis modalities, depressive symptoms are still present in approximately 25% of patients, rates comparable to that of the hemodialysis population. Correlates of depressive symptoms include marital status, income, kidney function, history of affective illness, malnutrition, and inflammation. Depressive symptoms are also associated with poor outcomes following kidney transplantation including nonadherence to immunosuppressant medication, graft failure, and all-cause mortality. Efforts to detect and treat depression should be a priority if one is to improve treatment adherence, quality of life, and outcomes in transplant recipients.
authors.affiliation: 1 Health Psychology Section, Psychology Department, Institute of Psychiatry, King's College London, UK. 2 Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK. 3 Department of Transplantation, Guy's Hospital, London, UK. 4 Address correspondence to: Joseph Chilcot, Ph.D., Health Psychology Section, Psychology Department, Institute of Psychiatry, King's College London, 5th floor Bermondsey Wing, Guy's Hospital Campus, London Bridge, London, SE1 9RT, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chilcot
authors.forename: Benjamin Walter Jack
authors.initials: BW
authors.lastname: Spencer
authors.forename: Hannah
authors.initials: H
authors.lastname: Maple
authors.forename: Nizam
authors.initials: N
authors.lastname: Mamode
mesh_terms: D003863:Depression / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000523:psychology*; D015995:Prevalence