title: Clinical and experimental observations of peripheral blood leukocytes and nucleated bone marrow cells after local irradiation.
abstract: OBJECTIVE
  Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia.
  
  
  METHODS
  For the human study, five cancer patients received local radiation therapy. Bone marrow aspiration was conducted to measure nucleated cell count and 99mTc-Sc sulfur colloid ECT imaging was carried out to examine bone marrow function. For the animal study, fifty New Zealand white rabbits were divided into 3 groups: non-irradiated control group (N.=10), abdomen irradiation group (irradiation area did not cover bone marrow) (N.=20), chest irradiation group (irradiation area covered bone marrow) (N.=20). Nucleated cell counts were taken after confirming onset of leukopenia.
  
  
  RESULTS
  Bone marrow of five patients proliferated normally. ECT imaging showed no abnormality in the pattern of red bone marrow distribution. Hematopoietic function was mildly active.
  
  
  CONCLUSIONS
  Suppressed myeloproliferative function does not fully account for irradiation-induced leukopenia.
authors.affiliation: Department of Hematology, Jiangsu University Affiliated Xuzhou Hospital (Xuzhou Tumor Hospital), Xuzhou, China - zxgjh1992@qq.com.
authors.forename: X G
authors.initials: XG
authors.lastname: Zhang
authors.forename: A N
authors.initials: AN
authors.lastname: Du
authors.forename: C
authors.initials: C
authors.lastname: Geng
authors.forename: F
authors.initials: F
authors.lastname: Guo
authors.forename: M
authors.initials: M
authors.lastname: He
authors.forename: F
authors.initials: F
authors.lastname: Gu
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: W B
authors.initials: WB
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: W
authors.initials: W
authors.lastname: Sheng
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Ye
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000528:radiation effects*; D001854:Bone Marrow Cells / Q000000981:diagnostic imaging / Q000528:radiation effects*; D049109:Cell Proliferation / Q000528:radiation effects; D004938:Esophageal Neoplasms / Q000532:radiotherapy; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007962:Leukocytes / Q000528:radiation effects*; D007970:Leukopenia / Q000209:etiology*; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D011817:Rabbits; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid