title: [Fluoroquinolones to prevent bacterial infection in children with chemotherapy induced neutropenia: is it reasonable?].
abstract: Chemotherapy-induced febrile neutropenia is a frequent event in children with cancer, with a high morbidity. Antibiotic prophylaxis has been proposed for many years to prevent infectious diseases in patients with neutropenia. Fluoroquinolone prophylaxis induced a significant reduction of mortality and infectious morbidities in these situations. Less data are available in children with neutropenia. The emergence of antimicrobial resistance involving not only quinolones, but also cephalosporins, aminoglycosides and penems, is the main long term risk. This article summarise the usefulness of the prophylactic antibiotic treatment and its perspective in children with cancer.
authors.affiliation: UDSL et EA2694 Santé publique : épidémiologie et qualité des soins, université Lille-2, université Lille-Nord-de France, rue Eugène-Avinée, 59000 Lille, France; Urgences pédiatriques et maladies infectieuses, CHRU Lille - Hôpital Roger-Salengro, 2 avenue Oscar-Lambret, 59000 Lille, France. Electronic address: francois.dubos@chru-lille.fr.
authors.forename: F
authors.initials: F
authors.lastname: Dubos
authors.affiliation: UDSL et EA2694 Santé publique : épidémiologie et qualité des soins, université Lille-2, université Lille-Nord-de France, rue Eugène-Avinée, 59000 Lille, France; Urgences pédiatriques et maladies infectieuses, CHRU Lille - Hôpital Roger-Salengro, 2 avenue Oscar-Lambret, 59000 Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Delebarre
authors.affiliation: Urgences pédiatriques et maladies infectieuses, CHRU Lille - Hôpital Roger-Salengro, 2 avenue Oscar-Lambret, 59000 Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Lagrée
mesh_terms: D019072:Antibiotic Prophylaxis; D000970:Antineoplastic Agents / Q000009:adverse effects; D001424:Bacterial Infections / Q000209:etiology* / Q000517:prevention & control*; D002648:Child; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*
chemical_list: D000970:Antineoplastic Agents; D024841:Fluoroquinolones