title: Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: a meta-analysis.
abstract: OBJECTIVE
  To perform a meta-analysis to compare the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury.
  
  
  METHODS
  Studies were included in the meta-analysis if they met the following criteria: randomized controlled trial of sedative-hypnotic agents including propofol and midazolam; patients had severe traumatic brain injury; the primary outcome was the Glasgow Outcome Scale score; secondary outcomes included mortality, therapeutic failure, intracranial pressure, and cerebral perfusion pressure. The data were analyzed using software for meta-analysis.
  
  
  RESULTS
  Seven relevant studies were identified. Three of these studies were excluded: one was a single-arm study, one compared morphine and propofol, and for one the full text article could not be obtained. The remaining 4 studies were included in the meta-analysis. The results of the meta-analysis showed that propofol and midazolam have similar effects on the Glasgow Outcome Scale score, mortality, intracranial pressure, and cerebral perfusion pressure.
  
  
  CONCLUSIONS
  Our meta-analysis of 4 studies showed that there are no important differences between propofol and midazolam when administered to provide sedation for patients with severe traumatic brain injury. Further randomized, controlled trials comparing propofol with midazolam for sedation of such patients are needed.
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China. Electronic address: gujianwen5000@gmail.com.
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Gu
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Yong-qin
authors.initials: YQ
authors.lastname: Kuang
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Hai-dong
authors.initials: HD
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Kong
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Shu
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Si-xun
authors.initials: SX
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu 610083, China.
authors.forename: Jun-hai
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000758:Anesthesia; D001930:Brain Injuries / Q000188:drug therapy* / Q000401:mortality; D002560:Cerebrovascular Circulation / Q000187:drug effects; D016292:Procedural Sedation / Q000379:methods; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D007427:Intracranial Pressure / Q000187:drug effects; D008874:Midazolam / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol
keywords: Midazolam; Propofol; Sedation; Traumatic brain injury