title: [Clinical role of evaluating vascular paralysis in septic shock patients].
abstract: OBJECTIVE
  To explore the effects of vascular paralysis upon prognosis and tissue perfusion in septic shock patients.
  
  
  METHODS
  A total of 73 septic shock patients consecutively admitted into our department from January 2010 to July 2011 were retrospectively studied. Their hemodynamic data, arterial lactate concentration and APACHEII (acute physiology & chronic health evaluation II) score at the beginning of cardiac output monitoring (0h), as well as the outcome of Day 28 post-diagnosis were recorded. Stroke volume index (SVI) and cardiac index (CI) were obtained through transpulmonary thermodilution technique by pulse induced continuous cardiac output (PiCCO) system.
  
  
  RESULTS
  (1) APACHEII score at 0h was higher in non-survivors than those in survivors ((14.6 ± 5.6) vs (20.4 ± 4.8), P < 0.01). Stroke systemic vascular resistance index (SSVRI), pulse pressure/stroke volume index (PP/SVI), effective arterial elastance index (EaI), 24h lactate clearance rate (24rLac) , 72h lactate clearance rate (72rLac) and 7d lactate clearance rate (7rLac) in non-survivors were all lower than those in survivors (P < 0.05); (2) SVRI, SSVRI, PP/SVI and EaI were all correlated significantly with 24rLac, 72rLac and 7rLac [ (212.7 ± 52.6) vs (185.4 ± 50.5) , PP/SVI: (2.8 ± 0.7) vs (2.5 ± 0.6), EaI: (5.0 ± 1.2) vs (4.3 ± 1.1), 24/72/7 rLac: (18.4 ± 46.4) vs (21.5 ± 49.7), (19.9 ± 49.6) vs (-21.5 ± 46.3), (35.5 ± 45.8) vs (-59.5 ± 64.5), P < 0.00].
  
  
  CONCLUSIONS
  Vascular paralysis is correlated with prognosis and tissue perfusion in septic shock patients. And SSVRI, PP/SVI and EaI are more significant.
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China; Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Su-wei
authors.initials: SW
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Wen-zhao
authors.initials: WZ
authors.lastname: Chai
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Xiu-kai
authors.initials: XK
authors.lastname: Chen
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Hong-min
authors.initials: HM
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China. Email: dwliu@medmail.com.cn.
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002302:Cardiac Output; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012772:Shock, Septic / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology*; D013318:Stroke Volume; D015996:Survival Rate; D014655:Vascular Resistance