title: [Effect of chemotherapy on the quality of life of lung cancer patients].
abstract: OBJECTIVE
  With development of modern medicine, eliminating patients' pain and mental disorder and improving the quality of life has become an important problem in patients with cancer. The aim of this study is to observe the impact of chemotherapy on quality of life and influencing factor of quality of life among lung cancer patients.
  
  
  METHODS
  Sixty-one lung cancer patients were assessed with clinical outcomes and the EORTC QLQ-C30 questionnaires before chemotherapy, one week after 2 cycles of chemotherapy, one week after 4 cycles of chemotherapy.
  
  
  RESULTS
  After 2 cycles of chemotherapy, effective rate was 40.0%. Social function decreased. Nause and vomiting, insomnia and appetite loss deteriorated (P<0.05). After 4 cycles of chemotherapy, effective rate was 23%. But after chemotherapy, physical, role, emotional, social function decreased; Appetite loss, nausea and vomiting, insomnia deteriorated, economics became difficult to some patients (P<0.05). In our study, we find female patients had more fatigue and appetite loss than male patients (P<0.05). Patients of low level of education had more fatigue and insomnia than patients of high level of education (P<0.05). Elder patients had more fatigue, appetite loss, nausea and vomiting than middle-aged patients (P<0.05). Grouped according to body mass index, the difference wasn't statistically significant (P>0.05). Grouped according to the plasma albumin level, the difference wasn't statistically significant (P>0.05). In hypoproteinemia group, symptoms and economic difficulties score was higher; High protein group, function and general health scores was higher.
  
  
  CONCLUSIONS
  After the chemotherapy, patients' the lesion of cancer became smaller and clinical symptoms relieved, but some patients, fatigue, appetite loss, nausea and vomiting symptom deteriorated, emotion became bad. Quality of life of lung cancer patients decrease. We should pay more attention to the adverse reactions of chemotherapy and cope with them, give positive psychological intervention and improve patients, nutrition to improve the quality of life.
authors.affiliation: Graduate School of Tianjin Medical University, Tianjin 300070, China;Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China;Department of Respiration, Tianjin Xiqing Hospital, Tianjin 300380, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Shufang
authors.initials: S
authors.lastname: Li
authors.forename: Shizhen
authors.initials: S
authors.lastname: Xin
authors.forename: Jiancun
authors.initials: J
authors.lastname: Cao
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents