title: Measles in a South African paediatric intensive care unit: again!
abstract: OBJECTIVE
  The aim of this study is to evaluate the outcomes of children with measles-related disease (MRD) admitted to a paediatric intensive care unit (PICU) and the effect on PICU resources and elective surgery of a recent measles epidemic.
  
  
  METHODS
  This was a retrospective observational study of all patients admitted to the PICU of Red Cross War Memorial Children's Hospital, Cape Town, South Africa, with MRD from January to December 2010. Patient admission characteristics, duration of PICU admission and mortality were recorded. Costs were calculated using bed days utilised and estimated daily PICU admission cost.
  
  
  RESULTS
  A total of 1274 children were admitted over the study period, 58 (4.6%) with MRD (median (interquartile range) age 7 (5-9) months). Pneumonia was the most common reason for admission (81%) and the main cause of mortality. Non-MRD mortality was 8.8% compared with MRD mortality of 31% (P < 0.0001). Standardised mortality for non-MRD was 0.7 versus 1.7 in MRD (P = 0.002). HIV comorbidity and being underweight for age were associated with increased mortality. Patients with MRD occupied 379 bed days with a median (interquartile range) duration of stay of 5.5 (3.0-9.0) days at an estimated overall cost of R4,813,300 (approximately $543,900). During the study period, 67 children booked for elective surgery, and 87 other referrals were refused PICU admission.
  
  
  CONCLUSIONS
  MRD was associated with significant morbidity and mortality, and substantial strain on scarce PICU resources.
authors.affiliation: Paediatric Intensive Care Unit, Red Cross War Memorial Children's Hospital, Cape Town, South Africa; School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
authors.forename: Saskia
authors.initials: S
authors.lastname: Coetzee
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Morrow
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Argent
mesh_terms: D005260:Female; D017721:Hospital Costs / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric / Q000191:economics / Q000706:statistics & numerical data*; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008457:Measles / Q000150:complications / Q000191:economics / Q000453:epidemiology* / Q000628:therapy; D011014:Pneumonia / Q000191:economics / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology; D016896:Treatment Outcome
keywords: HIV; intensive care; measles; measles prevention; measles-related disease; paediatric.