title: Application of 5-aminolevulinic acid-mediated photodynamic diagnosis to robot-assisted laparoscopic radical prostatectomy.
abstract: OBJECTIVE
  To determine the appropriate resection margin, we performed photodynamic diagnosis (PDD) mediated by 5-aminolevulinic acid (ALA; ALA-PDD) during robot-assisted laparoscopic radical prostatectomy (RALP).
  
  
  METHODS
  We performed ALA-PDD during RALP using da Vinci S Surgical System in 6 patients. The function of TilePro multi-image stereo-viewer enables simultaneous 2-tiered display of the real surgical field by the da Vinci S Surgical System and the ALA-PDD endoscopic system in surgeon console. The resection margins of prostate were biopsied under the observation of ALA-PDD and assessed pathologically.
  
  
  RESULTS
  The process of ALA-PDD during RALP was proceeded favorably in all the 6 patients. All 22 biopsy specimens obtained from resection margin of prostate demonstrated fluorescence-negative inside the body and also pathologically confirmed negative findings in malignancy. Moreover, no perioperative complications were observed through all procedures of ALA-PDD in all the 6 patients.
  
  
  CONCLUSIONS
  We presented particularly that application of ALA-PDD during RALP, as a novel and practical technique for decision of the correct resection margin.
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.forename: Shingo
authors.initials: S
authors.lastname: Ashida
authors.forename: Hideo
authors.initials: H
authors.lastname: Fukuhara
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iiyama
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kurabayashi
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Furihata
authors.forename: Taro
authors.initials: T
authors.lastname: Shuin
mesh_terms: D000368:Aged; D000622:Aminolevulinic Acid / Q000494:pharmacology*; D001706:Biopsy; D003936:Diagnosis, Computer-Assisted; D005453:Fluorescence; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011446:Prospective Studies; D011467:Prostate / Q000378:metabolism / Q000601:surgery*; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D012371:Robotics
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid