title: Small molecules targeting in vivo tissue regeneration.
abstract: The field of regenerative medicine has boomed in recent years thanks to milestone discoveries in stem cell biology and tissue engineering, which has been driving paradigm shifts in the pharmacotherapy of degenerative and ischemic diseases. Small molecule-mediated replenishment of lost and/or dysfunctional tissue in vivo, however, is still in its infancy due to a limited understanding of mechanisms that control such endogenous processes of tissue homeostasis or regeneration. Here, we discuss current progress using small molecules targeting in vivo aspects of regeneration, including adult stem cells, stem cell niches, and mechanisms of homing, mobilization, and engraftment as well as somatic cell proliferation. Many of these compounds derived from both knowledge-based design and screening campaigns, illustrating the feasibility of translating in vitro discovery to in vivo regeneration. These early examples of drug-mediated in vivo regeneration provide a glimpse of the future directions of in vivo regenerative medicine approaches.
authors.affiliation: Faculty of Chemistry & Chemical Biology, TU Dortmund University , Otto-Hahn-Str. 6, 44227 Dortmund, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Längle
authors.forename: Jonas
authors.initials: J
authors.lastname: Halver
authors.forename: Bernd
authors.initials: B
authors.lastname: Rathmer
authors.forename: Erik
authors.initials: E
authors.lastname: Willems
authors.forename: Dennis
authors.initials: D
authors.lastname: Schade
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D054852:Small Molecule Libraries