title: Six months of treatment with the endoscopic duodenal-jejunal bypass liner does not lead to decreased systemic inflammation in obese patients with type 2 diabetes.
abstract: Obesity is associated with chronic low-grade systemic inflammation. Bariatric surgery has been shown to reduce this inflammation. Here, the effect of a nonsurgical bariatric technique, the duodenal-jejunal bypass liner (DJBL), on systemic inflammation was investigated. Seventeen obese patients with type 2 diabetes were treated with the DJBL for 6 months. Plasma C-reactive protein (CRP), myeloperoxidase (MPO), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) were determined prior to and during DJBL treatment. Three months after initiation of DJBL treatment, TNF-α levels had increased from 1.8 ± 0.1 to 2.1 ± 0.1 pg/mL, whereas IL-6 increased from 2.7 ± 0.3 to 4.0 ± 0.5 pg/mL (both p < 0.05). CRP and MPO also increased, though the differences were not significant. After 6 months, the levels of all parameters were similar to baseline levels (CRP, 4.2 ± 0.6 mg/L; TNF-α, 2.0 ± 0.1 pg/mL; IL-6, 3.5 ± 0.5 pg/mL; MPO, 53.6 ± ng/mL; all p = ns compared to baseline). In the current study, 6 months of endoscopic DJBL treatment did not lead to decreased systemic inflammation.
authors.affiliation: Department of General Surgery and NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands, c.dejonge@maastrichtuniversity.nl.
authors.forename: Charlotte
authors.initials: C
authors.lastname: de Jonge
authors.forename: Sander S
authors.initials: SS
authors.lastname: Rensen
authors.forename: Hedwig M A
authors.initials: HM
authors.lastname: D'Agnolo
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Bouvy
authors.forename: Wim A
authors.initials: WA
authors.lastname: Buurman
authors.forename: Jan Willem M
authors.initials: JW
authors.lastname: Greve
mesh_terms: D050110:Bariatric Surgery / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000601:surgery*; D004386:Duodenum / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007249:Inflammation / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss