title: The awakening of DNA repair at Yale.
abstract: As a graduate student with Professor Richard Setlow at Yale in the late 1950s, I studied the effects of ultraviolet and visible light on the syntheses of DNA, RNA, and protein in bacteria. I reflect upon my research in the Yale Biophysics Department, my subsequent postdoctoral experiences, and the eventual analyses in the laboratories of Setlow, Paul Howard-Flanders, and myself that constituted the discovery of the ubiquitous pathway of DNA excision repair in the early 1960s. I then offer a brief perspective on a few more recent developments in the burgeoning DNA repair field and their relationships to human disease.
authors.affiliation: Department of Biology, Stanford University, California.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Hanawalt
mesh_terms: D003237:Connecticut; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects; D049673:History, 20th Century; D049674:History, 21st Century; D016296:Mutagenesis / Q000528:radiation effects; D012106:Research / Q000266:history* / Q000639:trends; D015398:Signal Transduction / Q000235:genetics*; D014466:Ultraviolet Rays; D014495:Universities
chemical_list: D004269:DNA, Bacterial
keywords: Cockayne syndrome; DNA repair history; UV sensitive syndrome; nucleotide excision repair; repair replication; transcription-coupled repair; ultraviolet light; xeroderma pigmentosum