title: [Advances in microbial genome reduction and modification].
abstract: Microbial genome reduction and modification are important strategies for constructing cellular chassis used for synthetic biology. This article summarized the essential genes and the methods to identify them in microorganisms, compared various strategies for microbial genome reduction, and analyzed the characteristics of some microorganisms with the minimized genome. This review shows the important role of genome reduction in constructing cellular chassis.
authors.forename: Jianli
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Wang
mesh_terms: D020043:Genes, Essential / Q000235:genetics*; D005818:Genetic Engineering; D064349:Genome, Microbial / Q000235:genetics*; D058615:Synthetic Biology / Q000379:methods*