title: Effect of periodontal treatment in renal transplant recipients.
abstract: OBJECTIVE
  To evaluate the effect of periodontal treatment on gingival overgrowth in a group of renal transplant patients.
  
  
  METHODS
  Twenty-five renal transplant recipients receiving immunosuppressive therapy with cyclosporine A (CsA) were randomly assigned to 2 groups. Group 1 (n = 15) included patients who had been specifically referred to a dental clinic to prevent gingival overgrowth and were given full periodontal therapy. Group 2 (n = 10) was comprised of patients who did not receive any professional periodontal cleaning. Patients from both groups were examined to determine their periodontal status before and after 3, 6 and 12 months in terms of their plaque index, gingival index and gingival overgrowth. During the examination, their overall health was stable.
  
  
  RESULTS
  For group 1, the scores were 1.89 (baseline), 0.98 (6 months) and 0.56 (12 months), and hence there were significant reductions (p = 0.0001). The gingival indices were 1.71 (baseline), 0.76 (6 months) and 0.35 (12 months), and the reductions were also significant (p = 0.0001). A significant association was observed between poor oral hygiene and the degree of gingival overgrowth. The 1-year post-treatment follow-up showed that patients in group 1 did not develop gingival overgrowth due to the use of CsA as group 2 did without prior periodontal therapy.
  
  
  CONCLUSIONS
  Oral hygiene status was the most important variable related to the development and degree of gingival overgrowth due to the use of CsA.
authors.affiliation: Department of Periodontology and Oral Medicine, Medical Faculty, University of Nis, Nis, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Pejcic
authors.forename: Vidojko
authors.initials: V
authors.lastname: Djordjevic
authors.forename: Draginja
authors.initials: D
authors.lastname: Kojovic
authors.forename: Vesna
authors.initials: V
authors.lastname: Zivkovic
authors.forename: Ivan
authors.initials: I
authors.lastname: Minic
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Mirkovic
authors.forename: Mariola
authors.initials: M
authors.lastname: Stojanovic
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects; D003774:Dental Plaque Index; D005260:Female; D019214:Gingival Overgrowth / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000379:methods*; D010512:Periodontal Index; D010517:Periodontics / Q000379:methods*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine