title: Prolonged response to trabectedin in a heavily pretreated patient with metastatic endometrial carcinoma: A case report and literature review.
abstract: ► We report the case of a heavily pretreated woman affected by metastatic endometrial carcinoma. ► Patient received Trabectedin as 10th line of treatment with an impressive clinical response. ► We evaluated BRCA1 and ERCC1 gene status which could be involved in Trabectedin sensitivity.
authors.affiliation: Medical Oncology 1, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Meoni
authors.affiliation: Medical Oncology 1, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Fabiana Letizia
authors.initials: FL
authors.lastname: Cecere
authors.affiliation: Laboratory of Molecular Biology, Universitary Hospital Germans Trial I Pujol, Badalona, Spain.
authors.forename: Imane
authors.initials: I
authors.lastname: Chaib
authors.affiliation: Medical Oncology 1, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Giommoni
authors.affiliation: Medical Oncology 1, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Costanzo
keywords: BRCA1; Chemotherapy; ERCC1; Endometrial carcinoma; Trabectedin