title: Variability in HOMA-IR, lipoprotein profile and selected hormones in young active men.
abstract: Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present study attempted to asses insulin resistance and its metabolic effects with respect to energy intake in young, lean, and active men. A total of 87 men aged 18-23 participated in the study. Plasma levels of glucose, insulin, lipoproteins, cortisol, and TSH were determined. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and calculated using homeostatic model. The median value of HOMA-IR (1.344) was used to divide subjects into two groups. Men did not differ in anthropometric parameters, daily physical activity, and plasma TSH and cortisol levels. However, in men with higher HOMA-IR significantly lower daily energy intake was observed concomitantly with higher TG, TC, and HDL-C concentrations in plasma versus their counterparts with lower HOMA-IR. Exclusively in subjects with higher HOMA-IR significant and positive correlation was noted between HOMA-IR and TC and LDL-C. We concluded that despite a normal body weight and physical activity, a subset of young men displayed unfavorable changes in insulin sensitivity and lipid profile, probably due to insufficient energy intake.
authors.affiliation: Department of Biochemistry and Biology, Józef Pilsudski University of Physical Education, P.O. Box 55, 01-968 Warsaw 45, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Keska
authors.affiliation: Department of Biochemistry and Biology, Józef Pilsudski University of Physical Education, P.O. Box 55, 01-968 Warsaw 45, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Lutoslawska
authors.affiliation: Department of Physiology, Józef Pilsudski University of Physical Education, P.O. Box 55, 01-968 Warsaw 45, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Czajkowska
authors.affiliation: Department of Biochemistry and Biology, Józef Pilsudski University of Physical Education, P.O. Box 55, 01-968 Warsaw 45, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Tkaczyk
authors.affiliation: Department of Sports Medicine, Józef Pilsudski University of Physical Education, P.O. Box 55, 01-968 Warsaw 45, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Mazurek
mesh_terms: D000328:Adult; D001786:Blood Glucose; D004734:Energy Metabolism; D006706:Homeostasis; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008954:Models, Biological; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D008074:Lipoproteins