title: Toward effective probiotics for autism and other neurodevelopmental disorders.
abstract: Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.
authors.affiliation: Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Gilbert
authors.affiliation: Swette Center for Environmental Biotechnology Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, AZ 85287-5701, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85287-5701, USA.
authors.forename: Rosa
authors.initials: R
authors.lastname: Krajmalnik-Brown
authors.affiliation: Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.
authors.forename: Dorota L
authors.initials: DL
authors.lastname: Porazinska
authors.affiliation: Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.
authors.forename: Sophie J
authors.initials: SJ
authors.lastname: Weiss
authors.affiliation: Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Boulder, CO 80309, USA. Electronic address: rob.knight@colorado.edu.
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
mesh_terms: D000818:Animals; D002659:Child Development Disorders, Pervasive / Q000382:microbiology*; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans