title: The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.
abstract: OBJECTIVE
  To evaluate the influence of type 2 diabetes on cancer-specific outcome in patients undergoing surgery for localized renal cell carcinoma (RCC).
  
  
  METHODS
  A total of 1,140 patients with localized RCC undergoing radical or partial nephrectomy were enrolled into this retrospective case-control study. Primary outcome was the cancer-specific survival comparing patients with and without type 2 diabetes at the time of surgery. Secondary outcomes were recurrence-free survival and metastases-free survival comparing the same groups. Additionally, the influence of accompanying factors on cancer-specific survival and overall survival of patients was evaluated in a multivariate analysis. Among 1,140 patients included in the analyses, 202 had diabetes at the time of surgery and 938 patients without diabetes served as control.
  
  
  RESULTS
  The univariate comparisons between patients with and without diabetes regarding recurrence-free, metastases-free, and cancer-specific survival revealed no significant differences. Multivariate results demonstrate that age, BMI, and diabetes had no significant effect on cancer-specific hazard among participants. After adjustment of the factors in terms of overall survival, however, increased age, increased BMI, and type 2 diabetes at the time of surgery were independent risk factors for the occurrence of the event death.
  
  
  CONCLUSIONS
  Type 2 diabetes and obesity at the time of surgery have no significant impact on cancer-specific and recurrence-free survival in patients with localized renal cancer.
authors.affiliation: Department of Urology, University Hospital Heidelberg, Heidelberg, Germany, kontakt@thomashoefner.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Höfner
authors.forename: Martin
authors.initials: M
authors.lastname: Zeier
authors.forename: Gencay
authors.initials: G
authors.lastname: Hatiboglu
authors.forename: Christian
authors.initials: C
authors.lastname: Eisen
authors.forename: Gita
authors.initials: G
authors.lastname: Schönberg
authors.forename: Boris
authors.initials: B
authors.lastname: Hadaschik
authors.forename: Dogu
authors.initials: D
authors.lastname: Teber
authors.forename: Stefan
authors.initials: S
authors.lastname: Duensing
authors.forename: Andreas
authors.initials: A
authors.lastname: Trumpp
authors.forename: Markus
authors.initials: M
authors.lastname: Hohenfellner
authors.forename: Sascha
authors.initials: S
authors.lastname: Pahernik
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000401:mortality* / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome