title: Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey.
abstract: OBJECTIVE
  Until the approval of patency capsule, capsule endoscopy (CE) has not been routinely applied for the diagnosis of Crohn's disease (CD) in Japan. We aimed to survey current situation of CE use for patients with CD in Japan.
  
  
  METHODS
  The nationwide survey of 40 Japanese institutions identified 94 patients with established CD (eCD) and 80 patients with suspected CD (sCD), who were examined by CE. Types and positive rates of mucosal injury under CE and capsule retention rate were investigated. In sCD, final diagnosis after CE was also analyzed.
  
  
  RESULTS
  Patients with eCD comprised 82 patients of ileitis or ileocolitis type, while 12 patients had CD of colitis type. CE identified mucosal injuries in 83 of 94 patients. Eight of 12 patients with eCD of colitis type had ileal lesions under CE, thereby being reclassified as ileocolitis type. In patients with sCD, CE detected mucosal injuries in 58 patients. Linear ulceration and cobblestone appearance were depicted in 22 and 3 patients, respectively, thereby resulting in established diagnosis of CD in 23 patients. Mucosal lesion was not found in 22 patients with sCD, who were diagnosed as not having CD. Capsule retention rate was not statistically different between patients with eCD and those with sCD (7.4% vs 6.3%, P = 1.0).
  
  
  CONCLUSIONS
  CE is useful for the evaluation of small bowel mucosal injuries in Japanese patients with sCD and eCD. Possible intestinal stricture needs to be carefully evaluated before CE even in patients with sCD.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Esaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Arakawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Minoru
authors.initials: M
authors.lastname: Matsuura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakase
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Sadaharu
authors.initials: S
authors.lastname: Nouda
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
authors.forename: Sei
authors.initials: S
authors.lastname: Kurokawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Motoya
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D053704:Capsule Endoscopy; D003424:Crohn Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D007564:Japan; D011795:Surveys and Questionnaires
keywords: Crohn's disease; capsule endoscopy; diagnosis; retention