title: Prospects for enhancement of targeted radionuclide therapy of cancer using ultrasound.
abstract: Ultrasound-mediated drug delivery is a promising means of enhancing delivery, distribution and effectiveness of drugs within tumours. In this review, prospects for exploiting ultrasound to improve the tumour delivery and distribution of radiolabelled antibodies for radioimmunotherapy and to overcome barriers imposed by tumour microenvironment are discussed.
authors.affiliation: King's College London, Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, 4th Floor Lambeth Wing, London, SE1 9EH, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Browning
authors.forename: Vineeth
authors.initials: V
authors.lastname: Rajkumar
authors.forename: R Barbara
authors.initials: RB
authors.lastname: Pedley
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Eckersley
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Blower
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000379:methods*; D014463:Ultrasonography
chemical_list: D000906:Antibodies
keywords: cancer; drug delivery; monoclonal antibodies; radioimmunotherapy; ultrasound