title: The common causes leading to pancytopenia in patients presenting to tertiary care hospital.
abstract: OBJECTIVE
  The objective of this study was to determine the frequency of common causes leading to Pancytopenia in patients presenting to tertiary care hospital at Karachi.
  
  
  METHODS
  A total of 62 patients with the diagnosis of Pancytopenia of more than one week duration were enrolled in the study. All patients underwent a detailed medical history and full physical examination followed by blood sampling for the investigations i.e. complete blood count with peripheral film, erythrocyte sedimentation rate (ESR), Malarial parasites (MP), liver function test, Renal function tests, PT and viral profile (HBsAg, Anti-HCV), Ultrasonography of abdomen. All patients underwent bone marrow aspiration and trephine biopsy for reporting and interpretation. Duration of study was six months, from May 2010 to November 2010.
  
  
  RESULTS
  The average age of the patients was 37.76 ± 16.38years. Out of 62 patients, 36 (58%) were male and 26 (42%) were female. Megaloblastic anemia was the commonest cause that was observed in 41.9% cases followed by acute myeloid leukemia 27.4%, aplastic anemia 19.4% and erythroid hyperplasia 11.3%. Conclusion : This study concluded that most common cause of pancytopenia is Megaloblastic anemia, followed by acute myeloid leukemia and aplastic anemia. Bone marrow examination is a single useful investigation which reveals the underlying cause in patients with pancytopenia.
authors.affiliation: Dr. Kirpal Das Makheja, Senior Registrar, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.forename: Kirpal
authors.initials: K
authors.lastname: Das Makheja
authors.affiliation: Dr. Bharat Kumar Maheshwari, Medical Officer, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.forename: Bharat
authors.initials: B
authors.lastname: Kumar Maheshwari
authors.affiliation: Dr. Shafique Arain, Registrar, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.forename: Shafique
authors.initials: S
authors.lastname: Arain
authors.affiliation: Dr. Suneel Kumar, Registrar, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.forename: Suneel
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Dr. Sangeeta Kumari, Medical Officer, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Kumari
authors.affiliation: Dr. Vikash, Medical Officer, Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
authors.lastname: Vikash
keywords: Aplastic Anemia; Bone Marrow Biopsy; Megaloblastic Anemia; Pancytopenia