title: Role of steroid therapy in pseudoxanthoma elasticum-like papillary dermal elastolysis.
abstract: Pseudoxanthoma Elasticum-like Papillary Dermal Elastolysis (PXE-PDE) is a peculiar idiopathic elastolytic disorder that clinically resembles Psudoxanthoma elasticum(PXE). It is histologically characterized by a total or partial loss of elastic fibers in the papillary dermis. It more often affects elderly women and is characterized by asymptomatic and symmetrical yellowish papules localized predominantly on the neck, supraclavicular regions, and flexural areas. After analyzing a series of cases and the recent literature suggesting that glucocorticoids may down-regulate the elastin gene expression and elastin mRNA, in cultured human skin fibroblasts, we think that high dose and prolonged steroid therapy may contribute to the appearance of PXE-PDE lesions.
authors.affiliation: Dermatology Unit, NESMOS Department, II School of Medicine, Sapienza University Rome, S. Andrea Hospital Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pranteda
authors.affiliation: Dermatology Unit, NESMOS Department, II School of Medicine, Sapienza University Rome, S. Andrea Hospital Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Muscianese
authors.affiliation: Dermatology Unit, NESMOS Department, II School of Medicine, Sapienza University Rome, S. Andrea Hospital Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Marmo
authors.affiliation: Dermatology Unit, NESMOS Department, II School of Medicine, Sapienza University Rome, S. Andrea Hospital Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Fidanza
authors.affiliation: Dermatology Unit, Faculty of Medicine, Umberto I Hospital, Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pranteda
authors.affiliation: Dermatology Unit, Complesso Integrato Columbus, Catholic University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tamburi
authors.affiliation: Dermatology Unit, Department of Health Sciences University Magna Graecia of Catanzaro, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Bottoni
authors.affiliation: Dermatology Unit, Department of Health Sciences University Magna Graecia of Catanzaro, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Nisticò
mesh_terms: D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011561:Pseudoxanthoma Elasticum / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone; D008775:Methylprednisolone