title: Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein: The INTERLIPID Study.
abstract: Objective. Despite considerable study, the relevance of leptin and adiponectin for atherosclerosis development is still unsettled. We investigated relations of serum leptin and adiponectin to serum C-reactive protein (CRP), using the INTERLIPID dataset on Japanese emigrants living in Hawaii and Japanese in Japan. Design and Methods. Serum leptin, adiponectin, and CRP were measured by standardized methods in men and women of ages 40 to 59 years from two population samples, one Japanese-American in Hawaii (83 men, 89 women) and the other Japanese in central Japan (111 men, 104 women). Participants with CRP >10 mg/L were excluded. Results. Sex-specific multiple linear regression analyses, with log-transformed leptin and adiponectin (log-leptin, log-adipo), site (Hawaii = 1, Japan = 0), SBP, HbA1c, smoking (cigarettes/day), and physical activity index score of the Framingham Offspring Study as covariates, showed that log-leptin directly related and log-adipo inversely related to log-CRP for both sexes (Ps < 0.05 to <0.01). Addition to the model of BMI and interaction terms (BMI × log-leptin, BMI × log-adipo, SITE × log-leptin, SITE × log-adipo) resulted in disappearance of statistical significance except for direct relation of log-leptin to log-CRP in men (P = 0.006). Conclusions. Leptin directly related to CRP independent of BMI and other confounding factors in men but not in women.
authors.affiliation: Cardiovascular Epidemiology, Kyoto Women's University, Kyoto 605-8501, Japan ; Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.affiliation: Department of Nutritional Epidemiology, National Institute of Health and Nutrition, Tokyo 162-8636, Japan.
authors.forename: Nagako
authors.initials: N
authors.lastname: Okuda
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.affiliation: Department of Preventive Medicine and Public Health, Keio University, Tokyo 160-8582, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.affiliation: First Institute for Health Promotion and Health Care, Tokyo 101-0061, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.affiliation: Department of Epidemiology and Research, National Heart Foundation Hospital & Research Institute, Dhaka 1216, Bangladesh.
authors.forename: Sohel R
authors.initials: SR
authors.lastname: Choudhury
authors.affiliation: John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rodriguez
authors.affiliation: John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
authors.forename: Kamal H
authors.initials: KH
authors.lastname: Masaki
authors.affiliation: Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Stamler