title: Comparison of the antidepressive effects of trans-resveratrol and 5-methoxy-7H-dibenzo[de,h]quinolin-7-one.
abstract: In this study we evaluate the in vivo antidepressant effect of a natural phenolic compound, trans-resveratrol, and a synthetic derivative from Menispermum dauricum DC (Menispermaceae) 5-methoxy-7H-dibenzo[de,h]quinolin-7- one known as 5-methoxyoxoisoaporphine (OXO 4). The antidepressant-like effect of trans-resveratrol and OXO 4 were evaluated through a Forced Swimming Test (FST), and they were compared with reference antidepressants: imipramine, desipramine, nomifensine, bupropion, nisoxetine, citalopram and moclobemide. Trans-resveratrol (10 mg/kg, intraperitoneally i.p. significantly decreased the immobility time in mouse model of despair test (69.03 ± 8.74 sec) p<0.05, as well as OXO 4 (1mg/kg, i.p. (60.92 ± 11.37 sec); p<0.05. We also evaluate the OXO 4 at 15, 30 and 45 min. affording the mayor reduction at 30 minutes after the administration. Thus, our results suggest that OXO 4 has a great antidepressant effect non-reported for this type of isoquinoline alkaloids. The pharmaceutical use of OXO 4 in the treatment of depressive disorders is a therapeutic alternative to be studied.
authors.forename: Miriam Cebey
authors.initials: MC
authors.lastname: López
authors.forename: José A
authors.initials: JA
authors.lastname: Fontenla
authors.forename: Eugenio
authors.initials: E
authors.lastname: Uriarte
authors.forename: Lourdes
authors.initials: L
authors.lastname: Santana
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. e.sobarzo@usc.es.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sobarzo-Sánchez
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001060:Aporphines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008815:Mice, Inbred Strains; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013550:Swimming
chemical_list: C000592626:5-methoxy-7H-dibenzo(de,h)quinolin-7-one; D000928:Antidepressive Agents; D001060:Aporphines; D013267:Stilbenes; C046292:bianfugecine; D000077185:Resveratrol