title: Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.
abstract: BACKGROUND
  Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied.
  
  
  METHODS
  One hundred and thirty non-dialysis patients with CKD were enrolled in the present study. Daily urinary excretion of sodium (representative of daily sodium intake) and BP was monitored in conditions of original eating habits. Estimated glomerular filtration rate (eGFR) was measured by the creatinine clearance (Ccr).
  
  
  RESULTS
  There was a linear positive relationship between the salt intake and systolic blood pressure (SBP) (β = 0.250, p = 0.004). It had been found that the log of BP/24-h urinary sodium (salt sensitivity index) had linear relationship with the log of eGFR (βsyst = -0.364, p = 0.000, βdiast = -0.345, p = 0.000, respectively). Multi-stepwise regression analysis showed SBP was mainly influenced by salt intake and eGFR. There was a negative correlation between diastolic blood pressure (DBP) and age.
  
  
  CONCLUSIONS
  These results demonstrated a linear relationship between the salt intake and SBP in non-dialysis patients with CKD. The salt sensitivity of BP rose with the decline of renal function.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital to Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Meng
authors.forename: Bin
authors.initials: B
authors.lastname: Fu
authors.forename: Tongyan
authors.initials: T
authors.lastname: Zhang
authors.forename: Zunmin
authors.initials: Z
authors.lastname: Han
authors.forename: Meijuan
authors.initials: M
authors.lastname: Yang
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000652:urine; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure; D003404:Creatinine / Q000652:urine; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology*; D012307:Risk Factors; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000652:urine; D013599:Systole
chemical_list: D000959:Antihypertensive Agents; D012982:Sodium, Dietary; D003404:Creatinine; D011188:Potassium