title: Complex logic functions implemented with quantum dot bionanophotonic circuits.
abstract: We combine quantum dots (QDs) with long-lifetime terbium complexes (Tb), a near-IR Alexa Fluor dye (A647), and self-assembling peptides to demonstrate combinatorial and sequential bionanophotonic logic devices that function by time-gated Förster resonance energy transfer (FRET). Upon excitation, the Tb-QD-A647 FRET-complex produces time-dependent photoluminescent signatures from multi-FRET pathways enabled by the capacitor-like behavior of the Tb. The unique photoluminescent signatures are manipulated by ratiometrically varying dye/Tb inputs and collection time. Fluorescent output is converted into Boolean logic states to create complex arithmetic circuits including the half-adder/half-subtractor, 2:1 multiplexer/1:2 demultiplexer, and a 3-digit, 16-combination keypad lock.
authors.affiliation: Center for Bio/Molecular Science and Engineering, Code 6900; ‡Optical Sciences Division, Code 5600; §Electronics Science and Technology Division, Code 6876; U.S. Naval Research Laboratory , Washington, D.C. 20375, United States.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Claussen
authors.forename: Niko
authors.initials: N
authors.lastname: Hildebrandt
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Susumu
authors.forename: Mario G
authors.initials: MG
authors.lastname: Ancona
authors.forename: Igor L
authors.initials: IL
authors.lastname: Medintz
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D036103:Nanotechnology / Q000295:instrumentation*; D055095:Optics and Photonics; D010455:Peptides / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D005456:Fluorescent Dyes; D010455:Peptides