title: [Effect of glutathione on blood coagulation function].
abstract: The purpose of this study was to investigate the effect of glutathione (GSH) on blood coagulation. The normal plasma samples and mixed plasma samples were taken randomly, and into which the normal dose and different concentration of GSH were added. The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and thrombin time (TT) were detected by using coagulation method before and after treatment with GSH. The detection results of normal plasma and mixed plasma containing GSH of different concentration were compared and analyzed with linear regression. The results showed that the APTT and FIB values of the plasma containing 2.5 mg/L glutathione or more, PT values of the plasma containing 10 mg/L glutathione or more, and TT values of the plasma containing 1250 mg/L glutathione or more were significantly different from those results of normal plasma or mixed plasma (P < 0.01) . There was a linear relation between all of the detection results of PT,APTT, FIB, TT and glutathione concentrations. The results of TT, APTT, PT and FIB detection in patient plasma were statistically different (P < 0.01) before and after treatment with normal concentration GSH. It is concluded that glutathione can influence detection results of coagulation function.
authors.affiliation: Department of Blood Transfusion, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China. E-mail:tongqingchen@126.com.
authors.forename: Tong-Qing
authors.initials: TQ
authors.lastname: Chen
authors.affiliation: Department of Neurology, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Chang-Chun
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Gastrointestinal Department, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Department of Medical Examination, Department of General Surgery, Department of Infectious, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Chen
authors.affiliation: Department of Medical Examination, Department of General Surgery, Department of Infectious, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Gu
authors.affiliation: Department of General Surgery, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Rong-Sheng
authors.initials: RS
authors.lastname: Xu
authors.affiliation: Department of Blood Transfusion, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Zhen-Xing
authors.initials: ZX
authors.lastname: Li
authors.affiliation: Department of Blood Transfusion, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wu
authors.affiliation: Department of Infectious, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei 230022,Anhui Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005978:Glutathione / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010949:Plasma; D011517:Prothrombin Time; D013918:Thrombin Time
chemical_list: D005340:Fibrinogen; D005978:Glutathione