title: The A930G polymorphism ofP22phox (CYBA) gene but not C242T variation is associated with hypertension: a meta-analysis.
abstract: BACKGROUND
  Recently, it has been reported that the A930G and C242T polymorphisms within p22phox (CYBA) gene are involved in the pathogenesis of hypertension. However, the results remain controversial. Furthermore, no previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. Therefore, we performed this meta-analysis to clarify these controversies.
  
  
  OBJECTIVE
  All of the included articles were retrieved from the PubMed and Embase databases, as well as the CNKI, CBM, Chongqing VIP and Wan Fang databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were used to assess the strength of the association. Accounting for heterogeneity, a fixed or random effects model was respectively adopted. Heterogeneity was checked using the Q test and the I(2) statistic. A cumulative meta-analysis was conducted to estimate the tendency of pooled OR. Funnel plots and Egger's tests were performed to test for possible publication bias.
  
  
  RESULTS
  Five articles on A930G with 2003 cases/2434 controls and eight articles on C242T with 2644 cases/1967 controls were identiﬁed. A signiﬁcant association of A930G polymorphisms with the risk of hypertension was found in the dominant model (OR=0.59, 95% CI: 0.38-0.92, p=0.021) and allelic model (OR=0.66, 95% CI: 0.46-0.95, p=0.024). In the stratified analysis, a signiﬁcant association could be found among the hospital-based and population-based studies. However, no evidence of a significant association of the C242T polymorphism with hypertension was found in the overall analysis and subgroup analysis.
  
  
  CONCLUSIONS
  This meta-analysis indicates that the A930G polymorphism, but not the C242T variation, might be a protective factor for hypertension.
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Yu-Wang
authors.initials: YW
authors.lastname: Qin
authors.affiliation: Pre-Clinical Faculty of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Peng
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Bao-Yun
authors.initials: BY
authors.lastname: Liang
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Xie
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D019255:NADPH Oxidases / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human