title: Sacroiliitis after use of oral isotretinoin--association with acne fulminans or adverse effect?
abstract: Acne fulminans is a rare and severe form of acne that may evolve from acne vulgaris, especially in male adolescents, or occur as an adverse effect of oral isotretinoin. Arthritis is a serious clinical manifestation when the musculoskeletal system is compromised by AF and has been reported as a rare adverse effect of isotretinoin. Involvement of the sacroiliac joints occurs in 21% of acne fulminans cases. We present the case of a 18-year-old male patient in whom acne fulminans evolved from acne vulgaris grade IV and after inflammation resolution started treatment with oral isotretinoin. Within a 30-day period of retinoid treatment he presented with back pain followed by rapid, progressive inability to deambulate.
authors.affiliation: Fundação de Dermatologia e Venereologia Alfredo da Matta, ManausAM, Brazil.
authors.forename: Ariane Silva Bastos
authors.initials: AS
authors.lastname: Geller
authors.affiliation: Fundação de Dermatologia e Venereologia Alfredo da Matta, ManausAM, Brazil.
authors.forename: Roberta Ferreira Nazareth
authors.initials: RF
authors.lastname: Alagia
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D011877:Radionuclide Imaging; D058566:Sacroiliitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin