title: Mitochondrial dysfunctions and altered metals homeostasis: new weapons to counteract HCV-related oxidative stress.
abstract: The hepatitis C virus (HCV) infection produces several pathological effects in host organism through a wide number of molecular/metabolic pathways. Today it is worldwide accepted that oxidative stress actively participates in HCV pathology, even if the antioxidant therapies adopted until now were scarcely effective. HCV causes oxidative stress by a variety of processes, such as activation of prooxidant enzymes, weakening of antioxidant defenses, organelle damage, and metals unbalance. A focal point, in HCV-related oxidative stress onset, is the mitochondrial failure. These organelles, known to be the "power plants" of cells, have a central role in energy production, metabolism, and metals homeostasis, mainly copper and iron. Furthermore, mitochondria are direct viral targets, because many HCV proteins associate with them. They are the main intracellular free radicals producers and targets. Mitochondrial dysfunctions play a key role in the metal imbalance. This event, today overlooked, is involved in oxidative stress exacerbation and may play a role in HCV life cycle. In this review, we summarize the role of mitochondria and metals in HCV-related oxidative stress, highlighting the need to consider their deregulation in the HCV-related liver damage and in the antiviral management of patients.
authors.affiliation: Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Via del Policlinico 155, 00161 Rome, Italy ; Francesco Balsano Foundation, Via G.B. Martini 6, 00198 Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Arciello
authors.affiliation: Francesco Balsano Foundation, Via G.B. Martini 6, 00198 Rome, Italy.
authors.forename: Manuele
authors.initials: M
authors.lastname: Gori
authors.affiliation: Francesco Balsano Foundation, Via G.B. Martini 6, 00198 Rome, Italy ; Institute of Molecular Biology and Pathology (IBPM); CNR, Piazzale Aldo Moro 7, 00185 Rome, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Balsano
mesh_terms: D000818:Animals; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D006706:Homeostasis; D006801:Humans; D008670:Metals / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress
chemical_list: D008670:Metals