title: [Determination of lead and isotope ratios in whole blood by inductively coupled plasma mass spectrometry].
abstract: OBJECTIVE
  To establish a method to determine lead and Isotope Ratios in whole blood by inductively coupled plasma mass spectrometry (ICP-MS).
  
  
  METHODS
  The whole blood samples was removed protein by 5% nitric acid , Online join thallium (Tl) as internal standard substance, used lyophilized bovine blood lead and cadmium standard material (GBW09139h and GBW09140h) for quality control of blood lead concentrations. Lead isotope standard substances (GBW04426) is used to determine the correction factor, lead isotope ratios will lead isotope standard reference material NIST SRM981 by icp-ms with samples for testing.
  
  
  RESULTS
  Optimize the detection method, detection of blood lead and lead isotope, and the method of linear range r >0.9999, GBW09139h and GBW09140h test results are within the scope of quality control. NIST SRM981 isotope determination precision RSD<1%, NIST SRM981 test results and the certificate of value close to.
  
  
  CONCLUSIONS
  The method is simple and convenient data is reliable, can meet the total lead (pb) in blood and former isotope simultaneous determination.
authors.affiliation: Department of Occupationgl Disease and Toxication , Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China.
authors.forename: Hui-ling
authors.initials: HL
authors.lastname: Li
authors.affiliation: Department of Occupationgl Disease and Toxication , Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Occupationgl Disease and Toxication , Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China.
authors.forename: Hong-shun
authors.initials: HS
authors.lastname: Zhang
authors.affiliation: Department of Occupationgl Disease and Toxication , Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China.
authors.forename: Cong-shen
authors.initials: CS
authors.lastname: Meng
authors.affiliation: Department of Occupationgl Disease and Toxication , Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China. E-mail: fengtonghao@sohu.com.
authors.forename: Feng-tong
authors.initials: FT
authors.lastname: Hao
mesh_terms: D000818:Animals; D002417:Cattle; D007854:Lead / Q000032:analysis / Q000097:blood; D007856:Lead Radioisotopes / Q000032:analysis / Q000097:blood; D013058:Mass Spectrometry / Q000379:methods*
chemical_list: D007856:Lead Radioisotopes; D007854:Lead