title: P2X3 and P2X2/3 receptor antagonists.
abstract: This review provides a concise summary of the molecular properties of the ligand-gated P2X receptors, in particular those containing the X3 subunit, as well as an overview comprising the most important patent applications on P2X3 and P2X2/3 receptor antagonists published since 2001. This review is mainly focused on small molecules with P2X3 and/or P2X2/3 antagonist properties. The most important classes of the patented compounds and conditions frequently claimed as their therapeutic targets are also discussed. Moreover, biological activity data from the cited patents and general prediction of druglikeness of the claimed compounds are also provided.
authors.affiliation: Gedeon Richter Plc., Budapest, 10. POB 27, H-1475, Hungary.
authors.forename: Hedvig
authors.initials: H
authors.lastname: Bölcskei
authors.forename: Bence
authors.initials: B
authors.lastname: Farkas
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D010330:Patents as Topic / Q000331:legislation & jurisprudence; D011485:Protein Binding / Q000502:physiology; D058919:Purinergic P2 Receptor Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D058476:Receptors, Purinergic P2X2 / Q000378:metabolism*; D058477:Receptors, Purinergic P2X3 / Q000378:metabolism*
chemical_list: D058919:Purinergic P2 Receptor Antagonists; D058476:Receptors, Purinergic P2X2; D058477:Receptors, Purinergic P2X3