title: Effect of Lippia sidoides in mouthrinses on de novo plaque formation: a double-blind clinical study in humans.
abstract: OBJECTIVE
  The aim of this study was to evaluate the antiplaque effect of Lippia sidoides (LS) by in vivo investigation.
  
  
  METHODS
  Ten healthy volunteers participated in a cross-over, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned initially to use just the following mouth rinses: Distilled water (negative control group), 0.12% chlorhexidine digluconate (positive control group) or 10% LS (test group). The plaque index was recorded in the six anterior upper teeth at the end of the trial and the one-way ANOVA and Bonferroni tests were used to estimate the difference among groups.
  
  
  RESULTS
  The clinical results did show statistically significant difference among three groups (P < 0.05), favoring the positive control group and test group, however, no difference in efficacy was found between them (P > 0.05).
  
  
  CONCLUSIONS
  The mouth rinses containing 0.12% chlorhexidine digluconate and 10% LS were equally able to inhibit plaque re-growth.
authors.forename: Italo Sarto Carvalho
authors.initials: IS
authors.lastname: Rodrigues
authors.forename: Danielle Braga
authors.initials: DB
authors.lastname: de Oliveira
authors.forename: Priscila Correia Bezerra
authors.initials: PC
authors.lastname: de Menezes
authors.forename: Flavio Nogueira
authors.initials: FN
authors.lastname: da Costa
authors.forename: Marlio Ximenes
authors.initials: MX
authors.lastname: Carlos
authors.affiliation: Departments of Periodontology, School of Dentistry, University of Fortaleza, UNIFOR, Fortaleza, CE, Brazil.
authors.forename: Sergio Luis da Silva
authors.initials: SL
authors.lastname: Pereira
mesh_terms: D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D032411:Lippia / Q000737:chemistry*; D009067:Mouthwashes; D012973:Sodium Hypochlorite / Q000494:pharmacology*
chemical_list: D009067:Mouthwashes; D012973:Sodium Hypochlorite