title: The management of thyroid nodules: a retrospective analysis of health insurance data.
abstract: BACKGROUND
  In Germany, about 59 000 thyroid operations are performed each year for uni- or multinodular goiter, most of them for diagnostic purposes. The rate of detection of thyroid cancer in such operations is relatively low, at 1:15. Evidence suggests that the preoperative tests recommended in guidelines for estimating the risk of cancer are not being performed as often as they should. In the present study, we determined the measures that were actually taken to diagnose and treat thyroid nodules and compared the findings with the guideline recommendations.
  
  
  METHODS
  We retrospectively analyzed data from a single, large statutory healthinsurance carrier in Germany (AOK), determining the diagnostic and therapeutic measures that were reimbursed for 25 600 patients in whom a uni- or multinodular goiter was newly diagnosed in the second quarter of 2006 (none of these patients had carried such a diagnosis 1 year previously). We recorded the diagnostic measures performed in the preceding 9 months and all other tests and treatments, including surgery and radioactive iodine treatment, in the 2 years thereafter.
  
  
  RESULTS
  Among patients who underwent surgery for uninodular goiter, the preoperative diagnostic studies included ultrasonography (in 100% of patients), scintigraphy (94%), measurement of thyroid-stimulating hormone (95%), measurement of calcitonin (9%), and fine-needle aspiration cytology (FNAC)(21%). An ultrasonographic examination was billed for only 28% of patients with uninodular goiter in the two years after the diagnosis was made. 13% of patients with uninodular goiter who were not operated on were given L-thyroxine, even though this is against guideline recommendations.
  
  
  CONCLUSIONS
  Inadequate preoperative risk stratification of thyroid nodules may explain the large number of thyroid operations that are performed for diagnostic purposes, resulting in a low percentage of malignancies detected. Preoperative FNAC and calcitonin measurement should be used in the diagnostic evaluation of thyroid nodules far more often than this is now done. As a rule, follow-up ultrasonography should be performed for all thyroid nodules that are not operated on. Patients with non-operated thyroid nodules should not be given thyroxine. A limitation of this study is that diagnostic measures were only recorded if they were performed in the 9 months before surgery, with earlier diagnostic measures (if any) being missed.
authors.affiliation: Division of Nephrology-Department of Internal Medicine, Neurology and Dermatology, Universitäts - medizin Leipzig, Wissenschaftliches Institut der AOK (WIdO, AOK's Scientific Institute), Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig.
authors.forename: Romy
authors.initials: R
authors.lastname: Wienhold
authors.forename: Markus
authors.initials: M
authors.lastname: Scholz
authors.forename: J Rgen-Bernhard
authors.initials: JR
authors.lastname: Adler
authors.forename: Christian
authors.initials: C
authors.lastname: G Nster
authors.forename: Ralf
authors.initials: R
authors.lastname: Paschke
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data*; D018579:Patient Selection; D015995:Prevalence; D011878:Radiotherapy / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D013965:Thyroidectomy / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D014463:Ultrasonography / Q000706:statistics & numerical data*; D055815:Young Adult