title: Crohn's disease susceptibility variants in Colombian tuberculosis patients.
abstract: BACKGROUND
  The molecular basis of genetic predisposition to pulmonary tuberculosis (PTB) in adults remains largely elusive. A chronic granulomatous inflammatory reaction is one of the main characteristics of the immune response to TB; however, a similar reaction is observed in other diseases, such as Crohn's disease.
  
  
  OBJECTIVE
  To assess the association of genetic polymorphisms previously associated with Crohn's disease and PTB in a Colombian population of PTB patients and controls.
  
  
  METHODS
  A case-control study was performed among 500 newly diagnosed PTB patients and 320 healthy control subjects. Thirty-one single nucleotide polymorphisms (SNPs) identified in a previous meta-analysis of genome-wide association studies of Crohn's disease were used for genotyping using MassARRAY technology.
  
  
  RESULTS
  In this study, we identified an association with borderline significance (P = 0.0009433 and P = 0.029 after multiple testing by Bonferroni's correction) of SNP rs10995271 with PTB. SNP rs10995271 is in linkage disequilibrium with SNPs belonging to the zinc finger protein (ZNF365) gene.
  
  
  CONCLUSIONS
  Our results suggest that human PTB shares a genetic basis with Crohn's disease, and that SNPs in the ZNF365 gene would have a role in the occurrence of chronic granulomatous inflammatory reaction in TB as well as Crohn's disease.
authors.affiliation: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia; Health Sciences Center, Louisiana Cancer Research Center, Louisiana State University, New Orleans, Louisiana, USA.
authors.forename: D
authors.initials: D
authors.lastname: Sánchez
authors.affiliation: Laboratory in Genetics and Genomic Medicine of Inflammation, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; ECOGENE-21 Clinical Trial Center, Centre de Médecine Génique Communautaire de l'Université de Montréal, Centre Hospitalier Affilié Universitaire Régional de Chicoutimi, Chicoutimi, Québec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Lefebvre
authors.affiliation: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia.
authors.forename: L F
authors.initials: LF
authors.lastname: García
authors.affiliation: Laboratory in Genetics and Genomic Medicine of Inflammation, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Rioux
authors.affiliation: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia.
authors.forename: L F
authors.initials: LF
authors.lastname: Barrera
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003105:Colombia / Q000453:epidemiology; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; C475725:ZNF365 protein, human