title: The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications.
abstract: Although it has long been known that mitochondria take up Ca2+, the molecular identities of the channels and transporters involved in this process were revealed only recently. Here, we discuss the recent work that has led to the characterization of the mitochondrial calcium uniporter complex, which includes the channel-forming subunit MCU (mitochondrial calcium uniporter) and its regulators MICU1, MICU2, MCUb, EMRE, MCUR1 and miR-25. We review not only the biochemical identities and structures of the proteins required for mitochondrial Ca2+ uptake but also their implications in different physiopathological contexts.
authors.affiliation: Signal Transduction Lab, c/o CUBO, via Fossato di Mortara 70, I-44121 Ferrara, Italy.  pnp@unife.it.
authors.forename: Saverio
authors.initials: S
authors.lastname: Marchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000502:physiology*; D008928:Mitochondria / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D028361:Mitochondrial Diseases / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D008956:Models, Chemical; D013329:Structure-Activity Relationship
chemical_list: D015220:Calcium Channels; C034703:mitochondrial calcium uniporter; D002118:Calcium