title: High mitochondrial accumulation of new gadolinium(III) agents within tumour cells.
abstract: The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.
authors.affiliation: School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. lou.rendina@sydney.edu.au.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Morrison
authors.forename: Jade B
authors.initials: JB
authors.lastname: Aitken
authors.forename: Martin D
authors.initials: MD
authors.lastname: de Jonge
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Ioppolo
authors.forename: Hugh H
authors.initials: HH
authors.lastname: Harris
authors.forename: Louis M
authors.initials: LM
authors.lastname: Rendina
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005682:Gadolinium / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D005682:Gadolinium