title: Hospitalization rates of complicated pneumococcal community-acquired pneumonia is increasing in Tuscan children.
abstract: To provide epidemiological data on community-acquired pneumonia (CAP) and complicated CAP, a retrospective study was conducted on a partially vaccinated paediatric population. Data from children hospitalized for CAP in Tuscan hospitals between January 1st, 1999 and December 31st, 2009 were analysed. A total of 5,450 children with CAP were hospitalized. Annual hospitalization rates for CAP did not change significantly over the study period (X2 for trend= 0.652; p=0.419). The total annual hospitalization rate for pneumococcal CAP varied according to age (28.04 per 100,000 children aged less than 5 years, 10.06 per 100,000 children aged 6-12 years and 0.98 per 100,000 children aged greater than13years). Hospitalization rates for pneumococcal CAP increased from12.84 (95 percent CI:7.35-18.34) in 2001 to 45.4 (95 percent CI:35.93-54.90) per 100,000 children aged less than 5 years in 2009 (p less than 0.0001). In addition, a significant increase of hospitalization rates for complicated CAP (from 6.07 in 1999 to 13.66 in 2009 per 100,000 children; P less than 0.0001) and pneumococcal complicated CAP (from 0.19 in 1999 to 3.41 in 2009 per 100,000 children) over the study period were highlighted. Our epidemiological data confirm the decision to introduce the PCV13 vaccine, to satisfy the need to prevent a wider group of pneumococcal serotypes.
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bonsignori
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Chiappini
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Orlandini
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Parretti
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sollai
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Resti
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Galli
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Azzari
authors.affiliation: Department of Sciences for Woman and Childs Health, Anna Meyer Childrens University Hospital, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Martino
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000150:complications*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D022242:Pneumococcal Vaccines / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000150:complications*; D012189:Retrospective Studies
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines