title: Rh(III)-catalyzed C-H amidation with N-hydroxycarbamates: a new entry to N-carbamate-protected arylamines.
abstract: An unprecedented Rh(III)-catalyzed direct intermolecular C-H amidation with N-hydroxycarbamates has been developed. Different directing groups, such as pyridine, pyrimidine, pyrazole, and N-OMe oxime, can be employed in this C-H amidation process, providing valuable N-carbamate-protected arylamines (e.g., Cbz, Moz, Ac, Boc, and Fmoc). More importantly, this process may afford a new avenue for intermolecular C-H amidation where readily available N-hydroxycarbamates can be used as the nitrogen source.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Du
authors.forename: Yaxi
authors.initials: Y
authors.lastname: Yang
authors.forename: Huijin
authors.initials: H
authors.lastname: Feng
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000577:Amides / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D002219:Carbamates; D012238:Rhodium; D009584:Nitrogen