title: Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats.
abstract: The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats. In preliminary screening, the ethanolic extract showed significant activity in Triton-treated rats. Bioassay-guided fractionation of the ethanolic extract resulted in the identification of four anthraquinone derivatives, viz. chrysophanol, emodin, chrysophanol 8-O-β-D-glucopyranoside and emodin 8-O-β-D-glucopyranoside as active constituents. All these compounds significantly reduced plasma lipid levels. The most active compound emodin showed significant lipid-lowering activity in the HFD-fed model. In addition, these compounds showed significant antioxidant activity. The effect of emodin on enzymes modulating lipid metabolism confirms and supports the efficiency of emodin as a potent antidyslipidemic agent.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Mishra
authors.forename: Shashi
authors.initials: S
authors.lastname: Tiwari
authors.forename: Atul
authors.initials: A
authors.lastname: Shrivastava
authors.forename: Shishir
authors.initials: S
authors.lastname: Srivastava
authors.forename: Goutam K
authors.initials: GK
authors.lastname: Boudh
authors.forename: Shivendra K
authors.initials: SK
authors.lastname: Chourasia
authors.forename: Upma
authors.initials: U
authors.lastname: Chaturvedi
authors.forename: Snober S
authors.initials: SS
authors.lastname: Mir
authors.forename: Anil K
authors.initials: AK
authors.lastname: Saxena
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: Vijai
authors.initials: V
authors.lastname: Lakshmi
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004642:Emodin / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011092:Polyethylene Glycols; D051381:Rats; D012250:Rheum / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D011092:Polyethylene Glycols; D004642:Emodin; C016811:tyloxapol