title: Neurotoxicity of immunosuppressive therapies in organ transplantation.
abstract: Immunosuppressive agents have revolutionized clinical transplantation medicine, allowing the avoidance of immune system attack on the transplanted graft. Nevertheless, the use of medications such as cyclosporine, tacrolimus and others also brought the side effects of these drugs. Early identification of drug-induced neurotoxicity in transplanted patients and of its specific causes is important, not only because of patient's poor clinical status but because of concomitant systemic and metabolic disorders which may obscure symptoms. Treatment and prognosis are highly dependent on the type of complication and it's early recognition. This review focuses on the clinical entities of neurotoxicity caused by immunosuppressive drugs in transplanted patients.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Fundeni Clinical Institute, Department of Neurology, Bucharest, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Anghel
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Fundeni Clinical Institute, Department of Neurology, Bucharest, Romania ; University of Nottingham, Academic Division of Clinical Neurology, Nottingham, UK.
authors.forename: Radu
authors.initials: R
authors.lastname: Tanasescu
authors.affiliation: Colentina Clinical Hospital, Department of Neurology, Bucharest, Romania.
authors.forename: Ana
authors.initials: A
authors.lastname: Campeanu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Fundeni Clinical Institute, Department of Radiology, Medical Imaging and Nuclear Medicine, Bucharest, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Lupescu
authors.affiliation: University of Nottingham, Academic Division of Clinical Neurology, Nottingham, UK.
authors.forename: Giulio
authors.initials: G
authors.lastname: Podda
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Emergency University Hospital, Department of Neurology, Bucharest, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Bajenaru
keywords: immunosuppressive drugs; neurotoxicity; posttransplant states