title: IL-7Rα: Mr Hyde's twists and turns.
abstract: In the current issue of Blood, Yokoyama et al demonstrate that an IL7R mutation similar to those found in patients with acute lymphoblastic leukemia (ALL) can be leukemogenic in vivo when expressed in normal hematopoietic progenitors.
authors.affiliation: INSTITUTO DE MEDICINA MOLECULAR.
authors.forename: João T
authors.initials: JT
authors.lastname: Barata
mesh_terms: D000818:Animals; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D015448:Leukemia, B-Cell / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000235:genetics*; D011247:Pregnancy; D020395:Receptors, Interleukin-7 / Q000235:genetics*
chemical_list: D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain