title: Evaluation of potential antidepressant-like activity of chalcone-1203 in various murine experimental depressant models.
abstract: Two classic animal behavior despair tests-the forced swimming test (FST) and the tail suspension test (TST) were used to evaluate antidepressant-like activity of a new chalcone compound, chalcone-1203 in mice. It was observed that chalcone-1203 at dose of 1, 5, and 10 mg/kg significantly reduced the immobility time in the FST and TST in mice 30 min after treatment. In addition, chalcone-1203 was found to exhibit significant oral activity in the FST in mice. It also produced a reduction in the ambulation in the open-field test in mice not previously habituated to the arena, but no effect in the locomotor activity in mice previously habituated to the open-field. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. It was found that chalcone-1203 significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus and cortex. Chalcone-1203 also significantly reduced the ratio of 5-HIAA/5-HT in the hippocampus and cortex, shown down 5-HT metabolism compared with mice treated with stress vehicle. In conclusion, chalcone-1203 produced significant antidepressant-like activity, and the mechanism of action may be due to increased 5-HT and NE in the mouse hippocampus and cortex.
authors.affiliation: Zhejiang Provincial Key Engineering Technology Research Center of Marine Biomedical Products, Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, 316000, Zhoushan, People's Republic of China, glp730@zjou.edu.cn.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Tang
authors.forename: Cheng-Yan
authors.initials: CY
authors.lastname: Pan
authors.forename: Shui-Lian
authors.initials: SL
authors.lastname: Zhao
authors.forename: Si-Hong
authors.initials: SH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D047188:Chalcones / Q000008:administration & dosage / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007103:Immobilization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013315:Stress, Psychological
chemical_list: D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D047188:Chalcones