title: Amphiphilic chitosan derivatives-based liposomes: synthesis, development, and properties as a carrier for sustained release of salidroside.
abstract: A novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesized. The structure of DCMCs was confirmed via FT-IR and (1)H NMR, and the critical micelle concentration (CMC) was investigated by fluorescence spectroscopy. The results indicated that DCMCs has hydrophilic carboxyl and hydrophobic methylene groups and the CMC value was 23.00 mg·L(-1). The polymeric liposomes (DCMCs/cholesterol liposomes, DC-Ls) were developed, and its properties were evaluated. The DC-Ls exhibited multilamellar spheres with positive charge (+73.30 mV), narrow size distribution (PDI = 0.277), and good crystal properties. Salidroside was first to encapsulate into DC-Ls. Compared with traditional liposomes (phosphatidylcholine/cholesterol liposome, PC-Ls), DC-Ls showed higher encapsulation efficiency (82.46%) and slower sustained release rate. The in vitro salidroside release from DC-Ls was governed by two distinct stages (i.e., burst release and sustained release) and was dependent on the pH of the release medium. The case II transport and case I Fichian diffusion were the main release mechanisms for the entire release procedure. These results indicated that DC-Ls may be a potential carrier system for the production of functional foods that contain salidroside or other bioactive food ingredients.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang, Jiangxi 330047, P.R. China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Peng
authors.forename: Wenjian
authors.initials: W
authors.lastname: Li
authors.forename: Fangjian
authors.initials: F
authors.lastname: Ning
authors.forename: Lihua
authors.initials: L
authors.lastname: Yao
authors.forename: Mei
authors.initials: M
authors.lastname: Luo
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Xiong
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation; D005960:Glucosides / Q000737:chemistry* / Q000493:pharmacokinetics; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D010636:Phenols / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005960:Glucosides; D008081:Liposomes; D010636:Phenols; D048271:Chitosan; D002784:Cholesterol; C009172:rhodioloside
keywords: amphiphilic chitosan; liposomes; release mechanism; salidroside; sustained release