title: Tannic Acid preferentially targets estrogen receptor-positive breast cancer.
abstract: Research efforts investigating the potential of natural compounds in the fight against cancer are growing. Tannic acid (TA) belongs to the class of hydrolysable tannins and is found in numerous plants and foods. TA is a potent collagen cross-linking agent; the purpose of this study was to generate TA-cross-linked beads and assess the effects on breast cancer cell growth. Collagen beads were stable at body temperature following crosslinking. Exposure to collagen beads with higher levels of TA inhibited proliferation and induced apoptosis in normal and cancer cells. TA-induced apoptosis involved activation of caspase 3/7 and caspase 9 but not caspase 8. Breast cancer cells expressing the estrogen receptor were more susceptible to the effects of TA. Taken together the results suggest that TA has the potential to become an anti-ER(+) breast cancer treatment or preventative agent.
authors.affiliation: Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Booth
authors.affiliation: Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Beau D
authors.initials: BD
authors.lastname: Inskeep
authors.affiliation: Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Hiral
authors.initials: H
authors.lastname: Shah
authors.affiliation: Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Jang Pyo
authors.initials: JP
authors.lastname: Park
authors.affiliation: Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Hay
authors.affiliation: Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC 29634, USA ; Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Karen J L
authors.initials: KJ
authors.lastname: Burg