title: Tandem C-2 functionalization-intramolecular azide-alkyne 1,3-dipolar cycloaddition reaction: a convenient route to highly diversified 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4]diazepines.
abstract: An efficient diversity-oriented synthetic approach to annulated 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4]diazepines has been developed using a Sc(OTf)3-catalyzed two-component tandem C-2 functionalization-intramolecular azide-alkyne 1,3-dipolar cycloaddition reaction. The reaction shows high substrate tolerance and provides a library of fused heterocycles that may lead to novel biologically active compounds or drug lead molecules.
authors.affiliation: Medicinal and Process Chemistry Division and §Molecular and Structural Biology Division, CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension, Sitapur Road Lucknow 226031, India.
authors.forename: Mohd Kamil
authors.initials: MK
authors.lastname: Hussain
authors.forename: Mohd Imran
authors.initials: MI
authors.lastname: Ansari
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.forename: Kanchan
authors.initials: K
authors.lastname: Hajela
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000480:Alkynes; D001381:Azepines; D001386:Azides; D006576:Heterocyclic Compounds, 4 or More Rings; D014230:Triazoles