title: Progressive central puberty in a toddler with partial androgen insensitivity.
abstract: A male infant was diagnosed with partial androgen insensitivity caused by a novel mutation in the androgen receptor. At 3.5 months of age, he received 100 mg of testosterone intramuscularly over the course of 3 months to increase phallic size. He developed pubic hair after 5 months and signs of progressive central precocious puberty when re-examined at 17.5 months, which subsequently was suppressed with depot leuprolide.
authors.affiliation: Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL.
authors.forename: Grace C
authors.initials: GC
authors.lastname: Dougan
authors.affiliation: Department of Pediatrics, Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH.
authors.forename: Naveen
authors.initials: N
authors.lastname: Uli
authors.affiliation: Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL. Electronic address: dshulman@health.usf.edu.
authors.forename: Dorothy I
authors.initials: DI
authors.lastname: Shulman
mesh_terms: D000374:Aggression / Q000187:drug effects; D019943:Amino Acid Substitution; D013734:Androgen-Insensitivity Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D000728:Androgens / Q000008:administration & dosage / Q000009:adverse effects*; D003692:Delayed-Action Preparations; D005091:Exons; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D057898:Hemizygote; D006801:Humans; D007021:Hypospadias / Q000209:etiology; D007231:Infant, Newborn; D016729:Leuprolide / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009154:Mutation; D010413:Penis / Q000002:abnormalities; D011629:Puberty, Precocious / Q000139:chemically induced*; D011944:Receptors, Androgen / Q000235:genetics; D012611:Scrotum / Q000002:abnormalities; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D000728:Androgens; D003692:Delayed-Action Preparations; D011944:Receptors, Androgen; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C004648:testosterone enanthate; D007986:Luteinizing Hormone; D016729:Leuprolide