title: Is leptin a predictive factor in patients with lung cancer?
abstract: OBJECTIVE
  The aim of this study was to evaluate the expression and clinical significance of leptin in lung cancer.
  
  
  METHODS
  126 patients with lung cancer ranged from 30 to 83years of age were studied. Serum leptin levels were determined by ELISA. The mRNA and protein levels of leptin in normal and lung cancer tissues were measured by RT-PCR and immunohistochemistry. The relationships between leptin levels and clinicopathological factors were evaluated by Wilcoxon rank sum or Kruskal-Wallis H test.
  
  
  RESULTS
  Serum leptin levels in lung cancer patients were significantly higher compared to those in controls and leptin expression in lung cancer tissue was markedly increased than that in normal lung tissue (both P<0.050).
  
  
  CONCLUSIONS
  Determination of leptin levels might provide useful predictive information for lung cancer.
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Cui-Hong
authors.initials: CH
authors.lastname: Song
authors.affiliation: Research Laboratory of Medical Experiment and Test Center, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liao
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Zi-Hui
authors.initials: ZH
authors.lastname: Deng
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Li
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liang
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Han
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, PR China. Electronic address: yan301@263.net.
authors.forename: Guang-Tao
authors.initials: GT
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011237:Predictive Value of Tests; D012333:RNA, Messenger / Q000097:blood; D012334:RNA, Neoplasm / Q000097:blood
chemical_list: D020738:Leptin; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm
keywords: Biomarker; Leptin; Lung cancer