title: Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
abstract: Two novel compounds, alienusolin, a 4α-deoxyphorbol ester (1), crotonimide C, a glutarimide alkaloid derivative (2), and ten known compounds, julocrotine (3), crotepoxide (4), monodeacetyl crotepoxide (5), dideacetylcrotepoxide, (6), β-senepoxide (7), α-senepoxide (8), (+)-(2S,3R-diacetoxy-1-benzoyloxymethylenecyclohex-4,6-diene (9), benzyl benzoate (10), acetyl aleuritolic (11), and 24-ethylcholesta-4,22-dien-3-one (12) were isolated from the Kenyan Croton alienus. The structures of the compounds were determined using NMR, GCMS, and HRESIMS studies.
authors.affiliation: Department of Chemistry, Nairobi University, Nairobi, Kenya.
authors.forename: Beth
authors.initials: B
authors.lastname: Ndunda
authors.affiliation: Department of Chemistry, FEPS, University of Surrey, Guildford, Surrey, United Kingdom.
authors.forename: Moses K
authors.initials: MK
authors.lastname: Langat
authors.affiliation: Department of Chemistry, Nairobi University, Nairobi, Kenya.
authors.forename: John M
authors.initials: JM
authors.lastname: Wanjohi
authors.affiliation: Department of Chemistry, Nairobi University, Nairobi, Kenya.
authors.forename: Jacob O
authors.initials: JO
authors.lastname: Midiwo
authors.affiliation: Department of Chemistry, Nairobi University, Nairobi, Kenya.
authors.forename: Leonidah O
authors.initials: LO
authors.lastname: Kerubo
mesh_terms: D000330:Aedes / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000852:Anopheles / Q000187:drug effects; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001549:Benzamides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D029802:Croton / Q000737:chemistry*; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects; D016488:Medicine, African Traditional; D015394:Molecular Structure; D010703:Phorbol Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010704:Phorbols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D001549:Benzamides; D004952:Esters; D010703:Phorbol Esters; D010704:Phorbols; D010881:Piperidones; C007864:glutarimide; C033085:phorbol