title: Palladium-catalyzed β-acyloxylation of simple amide via sp3 C-H activation.
abstract: β-Acyloxy amides are prepared in moderate to high yields by palladium-catalyzed acyloxylation of primary sp(3) C-H bonds from simple amides without any special directing group. A catalytic system of Pd(OAc)2/CF3CO2H/K2S2O8 is available to various amides with N-substituted by linear alkanes, cyclic alkanes, and electron-deficient benzyl compounds in this reaction. Acyloxylated products could be transformed easily to the corresponding β-hydroxy amides.
authors.affiliation: Department of Chemistry, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, People's Republic of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhou
authors.forename: Wenjun
authors.initials: W
authors.lastname: Lu