title: Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.
abstract: Helicase-primase inhibitors (HPIs) are the first new family of potent herpes virus (herpes simplex and varicella-zoster virus) inhibitors to go beyond the preliminary stages of investigation since the emergence of the original nucleoside analog inhibitors. To consider the clinical future of HPIs, this review puts the exciting new findings with two HPIs, amenamevir and pritelivir, into the historical context of antiviral development for the prevention and treatment of herpes simplex virus over the last century and, on this basis, the authors speculate on the potential evolution of these and other non-nucleoside inhibitors in the future.
authors.affiliation: Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Biswas
authors.forename: Soumi
authors.initials: S
authors.lastname: Sukla
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Field
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004265:DNA Helicases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D019915:DNA Primase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D010069:Oxadiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects / Q000201:enzymology*; D013449:Sulfonamides; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: C568714:ASP2151; D000998:Antiviral Agents; D010069:Oxadiazoles; D011725:Pyridines; D013449:Sulfonamides; D013844:Thiazoles; D014764:Viral Proteins; C453221:pritelivir; D019915:DNA Primase; D004265:DNA Helicases