title: EBV associated lymphomas in 2008 WHO classification.
abstract: Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that asymptomatically infects more than 90% of the world's population. The exact mechanism of EBV in oncogenesis is an area of active debate. However, EBV has been implicated in the pathogenesis of several kinds of lymphomas and lymphoproliferative disorders, including B-, T- and NK-cell derived. Subsequent studies have proven that the EBV gene expression product plays an activating and/or promoting role on lymphomagenesis, and paves the way for novel cellular therapies of EBV-associated lymphomas. This review concentrates on the pathology, morphology, treatment and prognosis of EBV-associated lymphomas in the 2008 WHO classification of tumors of hematopoietic and lymphoma tissues.
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Dalin
authors.initials: D
authors.lastname: Gao
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; Department of Pathology, General Hospital of Tianjin, Dagang, Oilfield, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Ge
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Electronic address: zhaiqiongli@126.com.
authors.forename: Qiongli
authors.initials: Q
authors.lastname: Zhai
mesh_terms: D000367:Age Factors; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000145:classification / Q000473:pathology* / Q000628:therapy; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006689:Hodgkin Disease / Q000145:classification / Q000473:pathology* / Q000628:therapy / Q000821:virology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification / Q000473:pathology* / Q000628:therapy / Q000821:virology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000145:classification / Q000473:pathology* / Q000628:therapy / Q000821:virology; D012737:Sex Factors; D014944:World Health Organization
keywords: B-cell lymphomas; Epstein-Barr virus; Hodgkin lymphoma; NK/T cell lymphomas