title: Early high volume lung lavage for acute severe smoke inhalation injury in dogs.
abstract: The aim of the present study was to investigate the safety and short‑term results of early high volume lung lavage in the treatment of acute severe smoke inhalation injuries in dogs. A high‑volume normal saline complex solution lavage in the left lung was performed 1 h subsequent to bilateral pulmonary acute severe sawdust smoke inhalation injury in dogs. Lavage of the right lung was conducted following an interval of 30 min or 4 h. The perfluorodecalin lavage was performed in dogs with unilateral pulmonary acute severe sawdust smoke inhalation injury. The present study identified that lavage with an interval of 4 h between two lungs was safer compared with a 30‑min interval. Following lavage, the increase in the levels of free radical metabolites and inflammatory mediators in the lung homogenate was reduced. Acute severe smoke inhalation injury in one lung evidently caused a secondary injury to the other lung in the dogs. Perfluorodecalin lavage did not achieve the same effect in cleansing the lungs as the normal saline, but a greater comprehensive short‑term outcome was obtained. These observations demonstrated that early high‑volume lung lavage following severe smoke inhalation injury could relieve primary injuries and secondary local and general inflammatory reactions in dogs. An improved comprehensive short‑term outcome was obtained in the perfluorodecalin‑lavaged dogs.
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Fachuan
authors.initials: F
authors.lastname: Nie
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Su
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Jinmei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Wanxiang
authors.initials: W
authors.lastname: Qin
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Suxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pain Care and Nonvascular Intervention, The First Subordinate Hospital, Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid; D002263:Carboxyhemoglobin / Q000032:analysis; D004195:Disease Models, Animal; D004285:Dogs; D005466:Fluorocarbons / Q000737:chemistry / Q000627:therapeutic use; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006439:Hemodynamics; D008297:Male; D010100:Oxygen / Q000097:blood; D011659:Pulmonary Gas Exchange; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D015208:Smoke Inhalation Injury / Q000473:pathology / Q000628:therapy*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D005466:Fluorocarbons; D005609:Free Radicals; D012462:Saline Solution, Hypertonic; C008805:perfluorodecalin; D002263:Carboxyhemoglobin; D010100:Oxygen