title: Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy.
abstract: We present an ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy (SD-OCPM) system that combines submicrometer transverse spatial resolution and subnanometer optical path length sensitivity, with an acquisition speed of over 217,000 voxels/s. The proposed SD-OCPM system overcomes two significant drawbacks of traditional common-path interferometers-limited transverse spatial resolution and suboptimal detection sensitivity-while maintaining phase stability that is comparable with common-path interferometer setups. The transverse and axial spatial resolution of the setup is measured to be 0.6 and 1.9 μm, respectively, with a phase sensitivity of 0.0027 rad (corresponds to optical path length sensitivity of 110 pm). High-speed acquisition allows for phase-sensitive 4D imaging of biological samples with subcellular resolution.
authors.forename: Rehman
authors.initials: R
authors.lastname: Ansari
authors.forename: Christian
authors.initials: C
authors.lastname: Myrtus
authors.forename: Redouane
authors.initials: R
authors.lastname: Aherrahrou
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Achim
authors.initials: A
authors.lastname: Schweikard
authors.forename: Gereon
authors.initials: G
authors.lastname: Hüttmann
mesh_terms: D032383:Myocytes, Cardiac / Q000166:cytology; D041623:Tomography, Optical Coherence / Q000379:methods*