title: The A640G polymorphism in the NAD(P)H oxidase p22phox gene (CYBA) is associated with risk reduction of coronary heart disease: a meta-analysis.
abstract: BACKGROUND
  Recently, studies have focused on the association between the p22phox gene A640G polymorphism and coronary heart disease (CHD). However, the results are inconsistent. In this study, we aimed to further evaluate this association by using meta-analysis.
  
  
  METHODS
  The PubMed, Embase, CBM, CNKI, WanFang and Chongqing VIP databases were searched for relevant articles. Hardy-Weinberg equilibrium (HWE) of the distribution of genotypes was tested using Pearson's chi-squared test. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were used to assess the strength of the association; Cochran's Q test and the I(2) statistic were used to evaluate heterogeneity. The random effects model and the fixed effects model were used according to heterogeneity; Begg's test and Egger's test were used to analyze publication bias. Sensitivity analysis was carried out to guarantee the stability of the results. Cumulative analysis was used to evaluate tendencies in the pooled OR.
  
  
  RESULTS
  A total of eight articles including 3904 CHD cases and 3498 controls were included. A significant association between the A640G polymorphism and CHD was observed in codominant model 2 (AG versus AA: OR=0.86, 95% CI: 0.77-0.96). In the subgroup analysis, a significant association was observed between the A640G polymorphism and CHD in Caucasians, and in PB (population-based), non-PB, HWE (studies followed HWE) and non-HWE studies.
  
  
  CONCLUSIONS
  Our results reveal that the A640G polymorphism may play a protective role in CHD.
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Baoyun
authors.initials: B
authors.lastname: Liang
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Qiugui
authors.initials: Q
authors.lastname: Wei
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Shen
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China. Electronic address: lujianqi@163.com.
authors.forename: Jianqi
authors.initials: J
authors.lastname: Lu
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003327:Coronary Disease / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D040242:Risk Reduction Behavior
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human
keywords: A640G; Coronary heart disease; Meta-analysis; NADPH oxidase; Polymorphism; p22phox