title: Bubble size distribution in acoustic droplet vaporization via dissolution using an ultrasound wide-beam method.
abstract: Performance and efficiency of numerous cavitation enhanced applications in a wide range of areas depend on the cavitation bubble size distribution. Therefore, cavitation bubble size estimation would be beneficial for biological and industrial applications that rely on cavitation. In this study, an acoustic method using a wide beam with low pressure is proposed to acquire the time intensity curve of the dissolution process for the cavitation bubble population and then determine the bubble size distribution. Dissolution of the cavitation bubbles in saline and in phase-shift nanodroplet emulsion diluted with undegassed or degassed saline was obtained to quantify the effects of pulse duration (PD) and acoustic power (AP) or peak negative pressure (PNP) of focused ultrasound on the size distribution of induced cavitation bubbles. It was found that an increase of PD will induce large bubbles while AP had only a little effect on the mean bubble size in saline. It was also recognized that longer PD and higher PNP increases the proportions of large and small bubbles, respectively, in suspensions of phase-shift nanodroplet emulsions. Moreover, degassing of the suspension tended to bring about smaller mean bubble size than the undegassed suspension. In addition, condensation of cavitation bubble produced in diluted suspension of phase-shift nanodroplet emulsion was involved in the calculation to discuss the effect of bubble condensation in the bubble size estimation in acoustic droplet vaporization. It was shown that calculation without considering the condensation might underestimate the mean bubble size and the calculation with considering the condensation might have more influence over the size distribution of small bubbles, but less effect on that of large bubbles. Without or with considering bubble condensation, the accessible minimum bubble radius was 0.4 or 1.7 μm and the step size was 0.3 μm. This acoustic technique provides an approach to estimate the size distribution of cavitation bubble population in opaque media and might be a promising tool for applications where it is desirable to tune the ultrasound parameters to control the size distribution of cavitation bubbles.
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Zong
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Wusong
authors.initials: W
authors.lastname: Li
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China. Electronic address: mxwan@mail.xjtu.edu.cn.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Wan
mesh_terms: D005740:Gases / Q000737:chemistry; D007700:Kinetics; D045423:Microbubbles; D011312:Pressure; D015203:Reproducibility of Results; D012965:Sodium Chloride / Q000737:chemistry; D013010:Sonication / Q000379:methods*; D013696:Temperature; D014835:Volatilization
chemical_list: D005740:Gases; D012965:Sodium Chloride
keywords: Acoustic droplet vaporization; Bubble dissolution; Bubble size distribution; Cavitation bubbles; Plane wave ultrasound