title: Neuronal rebound spiking, resonance frequency and theta cycle skipping may contribute to grid cell firing in medial entorhinal cortex.
abstract: Data show a relationship of cellular resonance and network oscillations in the entorhinal cortex to the spatial periodicity of grid cells. This paper presents a model that simulates the resonance and rebound spiking properties of entorhinal neurons to generate spatial periodicity dependent upon phasic input from medial septum. The model shows that a difference in spatial periodicity can result from a difference in neuronal resonance frequency that replicates data from several experiments. The model also demonstrates a functional role for the phenomenon of theta cycle skipping in the medial entorhinal cortex.
authors.affiliation: Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, , 2 Cummington St., Boston, MA 02215, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Hasselmo
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology*
chemical_list: D000109:Acetylcholine
keywords: entorhinal cortex; grid cells; head direction; place cells; rat; theta rhythm