title: [Correlation of single nucleotide polymorphisms of X-ray repair cross complementing group 1 gene to hereditary susceptibility of colorectal cancer].
abstract: OBJECTIVE
  To investigate the correlation of single nucleotide polymorphisms (SNP) of XRCC1 gene to hereditary susceptibility of colorectal cancer.
  
  
  METHODS
  XRCC1 genotypes in 124 colorectal cancer patients and 214 matched healthy people as control were analyzed by SnaP Shot SNP-typing technique. Five different inheritance models including codominant, dominant, recessive, overdominant and log-additive were analyzed using logistic regression model. The haplotype distribution was estimated with phase and its correlation with the risk of colorectal cancer was evaluated.
  
  
  RESULTS
  The frequencies of mutant 25487G-A, 25489C-T and 1799782C-T alleles were 0.20, 0.11, 0.32 respectively in the patients, and 0.23, 0.13, 0.34 in the controls. There was no significant correlation of polymophisms of XRCC1 gene to the risk of colorectal cancer in 5 different inheritance models (P>0.05). GCT, GCC, ACC and GTC were the most common haplotypes and the odds ratios were 1, 1.35, 0.90 and 0.84 respectively. There was no significant difference of distribution between 2 groups in haplotypes.
  
  
  CONCLUSIONS
  Polymorphisms of XRCC1 gene, including rs25487, rs25489, rs1799782, are not associated with to the risk of colorectal cancer.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital, Suzhou University, Suzhou 215004, China. xingcg@126.com.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Yang
authors.forename: Chun-gen
authors.initials: CG
authors.lastname: Xing
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Yong-you
authors.initials: YY
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Feng-yun
authors.initials: FY
authors.lastname: Zhong
authors.forename: Teng-fei
authors.initials: TF
authors.lastname: He
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human