title: Solitary lesions with fibrosis and increased IgG4+ plasma cells: part of the expanding spectrum of IgG4-related disease or a nonspecific inflammatory response?
abstract: We assessed 6 cases acquired during routine surgical sign-out for IgG4-related disease (IRD) according to criteria from a recent consensus meeting. These cases fulfilled the morphologic criteria-that is, dense lymphoplasmacytic infiltrates, IgG4:IgG ratio greater than or equal to 0.4, and fibrosis (storiform in 4 cases-but were associated with malignancy or did not fulfill the criteria for a new site. These criteria include increased serum IgG4 (normal in the majority of IRD) and a response to glucocorticoids, which is not appropriate treatment for resectable lesions as in our cases. Until more is known about the natural history of the disease, we propose that the possibility of an early, localized, or forme fruste of IRD should be considered and that cases associated with malignancy should at least be documented. Although we acknowledge the value of the consensus criteria, their strict application may result in missed opportunities to study the disease.
authors.affiliation: 1Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Lik Hang
authors.initials: LH
authors.lastname: Lee
authors.forename: Eldon A
authors.initials: EA
authors.lastname: Shaffer
authors.forename: Vincent
authors.initials: V
authors.lastname: Falck
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Kelly
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D003111:Colonic Polyps / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4-related disease; autoimmune diseases; immunoglobulin G; plasma cells