title: [Epithelial cell in intestinal homeostasis and inflammatory bowel diseases].
abstract: Crohn's disease (CD) and ulcerative colitis (UC) are the principal inflammatory bowel diseases (IBD) which physiopathology is currently poorly elucidated. During these diseases, the participation of the epithelial cell in the installation and the perpetuation of the intestinal inflammation is now clearly implicated. In fact, the intestinal epithelium located at the interface between the internal environment and the intestinal luminal, is key to the homeostatic regulation of the intestinal barrier. This barrier can schematically be regarded as being three barriers in one: a physical, chemical and immune barrier. The barrier function of epithelial cell can be altered by various mechanisms as occurs in IBD. The goal of this article is to review the literature on the role of the epithelial cell in intestinal homeostasis and its implication in the IBD.
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie - Service de gastro-entérologie A, rue Jabbari, hôpital La Rabta, 1007 Tunis, Tunisie.
authors.forename: Lilia
authors.initials: L
authors.lastname: Zouiten-Mekki
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Meriem
authors.initials: M
authors.lastname: Serghini
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Monia
authors.initials: M
authors.lastname: Fekih
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Lamia
authors.initials: L
authors.lastname: Kallel
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Samira
authors.initials: S
authors.lastname: Matri
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Nadia
authors.initials: N
authors.lastname: Ben Mustapha
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Jalel
authors.initials: J
authors.lastname: Boubaker
authors.affiliation: Laboratoire de physiologie, faculté de médecine de Tunis, Tunis, Tunisie.
authors.forename: Azza
authors.initials: A
authors.lastname: Filali
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative; D003424:Crohn Disease; D004847:Epithelial Cells / Q000276:immunology / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000503:physiopathology*; D007422:Intestines / Q000503:physiopathology*