title: Lycorine: a potential broad-spectrum agent against crop pathogenic fungi.
abstract: A screening test showed that lycorine exhibited significant antifungal activity against 24 pathogenic crop fungi at concentrations of 500 μg/ml and 100 μg/ml, respectively. Fusarium graminearum was selected for antifungal mechanism studies by observing its mycelial morphology and investigating the variations in its conductivity. In addition, the substance absorption and metabolism of F. graminearum were explored. The mechanism was revealed as being one by which lycorine destroyed the cellular membrane and further influenced substance absorption and cell metabolism.
authors.affiliation: College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Shen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Bing-Ji
authors.initials: BJ
authors.lastname: Ma
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Zheng
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D005670:Fusarium / Q000166:cytology / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D025282:Mycelium / Q000166:cytology / Q000187:drug effects; D010617:Phenanthridines / Q000494:pharmacology*; D010944:Plants / Q000382:microbiology*
chemical_list: D047151:Amaryllidaceae Alkaloids; D000935:Antifungal Agents; D010617:Phenanthridines; C015330:lycorine