title: Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly.
abstract: BACKGROUND
  Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.
  
  
  METHODS
  In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
  
  
  RESULTS
  After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
  
  
  CONCLUSIONS
  Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.
authors.affiliation: Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France. emmanuelle.duron@brc.aphp.fr.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Duron
authors.affiliation: Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Vidal
authors.affiliation: INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Funalot
authors.affiliation: IINSERM, UMRS. 938, Centre de Recherche St-Antoine, Paris, France.
authors.forename: Nadège
authors.initials: N
authors.lastname: Brunel
authors.affiliation: INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Viollet
authors.affiliation: Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Seux
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. Unite d'Epidemiologie et de Biostatistique, Hotel Dieu, Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Treluyer
authors.affiliation: INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.affiliation: IINSERM, UMRS. 938, Centre de Recherche St-Antoine, Paris, France.
authors.forename: Yves Le
authors.initials: YL
authors.lastname: Bouc
authors.affiliation: Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. emmanuelle.duron@brc.aphp.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D016015:Logistic Models; D008297:Male
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: Atrial fibrillation; Elderly participants; Insulin-like growth factor binding protein-3.; Insulin-like growth factor-I