title: Interferon gamma, interleukin 8 and interleukin 10 in serum of patients with the cervical infection and symptoms of the imminent preterm delivery.
abstract: BACKGROUND
  Preterm delivery (PTD), defined as a delivery between 24th and 37th completed week, increases the risk of neonatal morbidity and mortality. There is a growing body of evidence that the intrauterine infection as well as cervicovaginal bacterial infections and Chlamydia infections are possible causes of preterm delivery. Host response to cervicovaginal and/or intrauterine infections is coupled with a release of various inflammatory mediators, many of which are cytokines.
  
  
  OBJECTIVE
  The aim of the study was to find out if cervical infection influenced the serum levels of interferon-gamma (IFN-gamma), interleukin 8 (IL-8) and interleukin 10 (IL-10) in patients with the clinical symptoms of the imminent preterm delivery.
  
  
  METHODS
  A total of 128 pregnant women (from 24 to 30 weeks of gestation) with the clinical symptoms of the imminent preterm delivery were divided in: study group--85 patients with the cervical infection, and control group--43 patients without the cervical infection. The level of cytokines in the serum was measured with commercial ELISA tests.
  
  
  RESULTS
  No significant difference could be found in serum levels of IFN-gamma (p = 0.632), IL-8 (p = 0.712) and IL-10 (p = 0.676) between these two investigated groups.
  
  
  CONCLUSIONS
  The results of our study suggest that there is no significant difference in serum IFN-gamma, IL-8 and IL-10 concentrations between pregnant women with the symptoms of the imminent preterm delivery who had and had no cervical infection.
authors.affiliation: Faculty of Medicine, University of Novi Sad, Serbia. mbogavac@yahoo.com
authors.forename: Mirjana
authors.initials: M
authors.lastname: Bogavac
authors.affiliation: Faculty of Medicine, University of Novi Sad, Serbia.
authors.forename: Snezana
authors.initials: S
authors.lastname: Brkić
authors.affiliation: Faculty of Medicine, University of Novi Sad, Serbia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Celić
authors.affiliation: Department of Chemistry, Faculty of Sciences, Novi Sad, Serbia.
authors.forename: Nataja
authors.initials: N
authors.lastname: Simin
authors.affiliation: Faculty of Medicine, University of Novi Sad, Serbia.
authors.forename: Jovan
authors.initials: J
authors.lastname: Matijasević
authors.affiliation: Faculty of Medicine, University of Novi Sad, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ilić
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000382:microbiology; D002577:Uterine Cervical Diseases / Q000097:blood* / Q000382:microbiology; D055815:Young Adult
chemical_list: D016209:Interleukin-8; D016753:Interleukin-10; D007371:Interferon-gamma