title: Inhibition of the mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine by indenopyridines in the Salmonella typhimurium tester strain 1537 and E. coli.
abstract: The goal of the present research was to determine the protective potential of five newly synthesized indenopyridine derivatives against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA) induced mutagenesis. MNNG sensitive Escherichia coli WP2uvrA and 9-AA sensitive Salmonella typhimurium TA1537 were chosen as the bacterial tester strains. All of the test compounds showed significant antimutagenic activity at various tested concentrations. The inhibition rates ranged from 25.6% (Compound 2 - 1 mM/plate) to 68.2% (Compound 1 - 2.5 mM/plate) for MNNG and from 25.7% (Compound 4 - 1 mM/plate) to 76.1% (Compound 3 - 2.5 mM/plate) for 9-AA genotoxicity. Moreover, the mutagenicity of the test compounds was investigated by using the same strains. None of the test compounds has mutagenic properties on the bacterial strains at the highest concentration of 2.5 mM. Thus, the findings of the present study give valuable clues to develop new strategies for chemical prevention from MNNG and 9-AA genotoxicity by using synthetic indenopyridine derivatives.
authors.affiliation: Department of Chemistry, Yildiz Technical University , Istanbul , Turkey and.
authors.forename: Kadir
authors.initials: K
authors.lastname: Turhan
authors.forename: S Arda
authors.initials: SA
authors.lastname: Ozturkcan
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Turgut
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadayi
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
mesh_terms: D000585:Aminacrine / Q000633:toxicity; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics; D007192:Indenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011725:Pyridines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D016587:Antimutagenic Agents; D007192:Indenes; D009153:Mutagens; D011725:Pyridines; D008769:Methylnitronitrosoguanidine; D000585:Aminacrine
keywords: Ames/Salmonella test; E. coli WP2 test; antimutagenicity; indenopyridine derivatives; indenopyridines; mutagenicity