title: Effect of obesity on TAFI in postmenopausal period.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  The aim of the study was to evaluate how obesity effects the coagulation and fibrinolytic system in the postmenopausal period.
  
  
  METHODS
  Forty-eight obese (body mass index (BMI) ≥30 kg/m(2)) and 38 nonobese (BMI < 30 kg/m(2)) postmenopausal women were enrolled in the study. Fat mass and insulin resistance were calculated. Plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), d-dimer, thrombomodulin, and thrombin activatable fibrinolysis inhibitor (TAFI) antigen were determined by ELISA method. TAFI activity was measured using the chromogenic assay.
  
  
  RESULTS
  Obese subjects had higher PAI-1 (73.5 ± 35.7 ng/mL vs. 57.1 ± 34.2 ng/mL, p < 0.05) levels but lower tPA/PAI-1 ratio (0.59 ± 0.50 vs. 38 ± 0.21, p < 0.05) than their nonobese counterparts. Obesity was not statistically significant for other haemostatic variables. BMI and fat mass were positively correlated with PAI-1 (r = 0.312, p = 0.003; r = 0.381, p = 0.005, respectively) and negatively correlated with tPA/PAI-1 ratio (r = -0.273, p = 0.01; r = -0.545, p = 0.01, respectively). HOMA scores were also positively correlated with PAI-1 levels (r = 0.236, p = 0.04).
  
  
  CONCLUSIONS
  We found that tendency to hypercoagulability in the postmenopausal women was due to increased PAI-1 rather than TAFI levels, which may contribute to adverse cardiovascular outcomes in this cohort. Further studies should be undertaken to evaluate effects of weight loss on the coagulation and fibrinolytic system.
authors.affiliation: Trakya University, Department of Endocrinology, Turkey. Electronic address:barbe7426@yahoo.com.
authors.forename: Bengur
authors.initials: B
authors.lastname: Taskiran
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Guldiken
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Ahmet M
authors.initials: AM
authors.lastname: Demir
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Tulay K
authors.initials: TK
authors.lastname: Okman
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Arikan
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Turgut
authors.affiliation: Trakya University, Department of Endocrinology, Turkey.
authors.forename: Ayse A
authors.initials: AA
authors.lastname: Tugrul