title: A critical appraisal of microemulsions for drug delivery: part II.
abstract: Microemulsions are thermodynamically stable, optically transparent isotropic solutions of oil and water successfully formulated by using a combination of suitable surfactant and cosurfactant. The solubilization power of microemulsions for lipophilic, hydrophilic and amphiphilic solutes form a viable approach for enhancing the bioavailability of hydrophobic drugs and percutaneous permeation of poorly permeable drugs, mainly due to the large area per volume ratio available for mass transfer. Microemulsions have emerged as novel vehicles for drug delivery due to their versatile applications. They allow sustained release for topical, oral, nasal, intravenous, ocular, parenteral and other administration routes of drugs. They also offer a relevant application platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs.
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala 147 002, India.
authors.forename: Bharti
authors.initials: B
authors.lastname: Sapra
authors.forename: Purva
authors.initials: P
authors.lastname: Thatai
authors.forename: Sameer
authors.initials: S
authors.lastname: Bhandari
authors.forename: Jatin
authors.initials: J
authors.lastname: Sood
authors.forename: Manish
authors.initials: M
authors.lastname: Jindal
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwary
mesh_terms: D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000818:Animals; D003358:Cosmetics; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D006801:Humans; D007263:Infusions, Parenteral; D009883:Ophthalmic Solutions
chemical_list: D003358:Cosmetics; D004337:Drug Carriers; D004655:Emulsions; D009883:Ophthalmic Solutions