title: Vulvoperineal Crohn's disease responsive to metronidazole.
abstract: Crohn's disease is a multisystem chronic granulomatous inflammatory disease that primarily affects the gastrointestinal tract. In the majority of the cases, the cutaneous manifestations follow the intestinal disease, but occasionally dermatological lesions are the inaugural event and may constitute the only sign of the disease. Vulvoperineal involvement is rare, may precede bowel symptoms by months to years and may go unrecognized. Due to the paucity of reports of Crohn's disease at this location and in the absence of randomized trials, there are no standard treatments for the cutaneous disease. We describe the case of a 47 year-old woman with vulvoperineal Crohn's disease without digestive involvement, that was successfully managed with metronidazole.
authors.affiliation: Hospital Center at Porto, Hospital de Santo António, Porto, Portugal.
authors.forename: Aristóteles
authors.initials: A
authors.lastname: Rosmaninho
authors.affiliation: Hospital Center at Porto, Hospital de Santo António, Porto, Portugal.
authors.forename: Madalena
authors.initials: M
authors.lastname: Sanches
authors.affiliation: Hospital de Santo António, Hospital Center at Porto, Porto, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Salgado
authors.affiliation: Hospital Center at Porto, Hospital de Santo António, Porto, Portugal.
authors.forename: Rosário
authors.initials: R
authors.lastname: Alves
authors.affiliation: Hospital de Santo António, Hospital Center at Porto, Porto, Portugal.
authors.forename: Manuela
authors.initials: M
authors.lastname: Selores
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001706:Biopsy; D003424:Crohn Disease / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D010502:Perineum / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole