title: A formin-g role during development and disease.
abstract: Several different protein families were shown to be involved in the regulation of actin filament formation and have been studied extensively in processes such as cell migration. Among them are members of the formin family, which tend to promote the formation of linear actin filaments. Studies in recent years, often using loss of function animal models, have indicated that formin family members play roles beyond cell motility in vitro and are involved in processes ranging from tissue morphogenesis and cell differentiation to diseases such as cancer and cardiomyopathy. Therefore the aim of this review is to discuss these findings and to start putting them into a subcellular context.
authors.affiliation: Randall Division of Cell and Molecular Biophysics, Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, United Kingdom.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Randall
authors.affiliation: Randall Division of Cell and Molecular Biophysics, Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, United Kingdom. Electronic address: Elisabeth.ehler@kcl.ac.uk.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ehler
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement; D047108:Embryonic Development; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D008840:Microfilament Proteins
keywords: Actin cytoskeleton; DRF; Formin