title: Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.
abstract: The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.
authors.affiliation: Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536, United States.
authors.forename: Xiachang
authors.initials: X
authors.lastname: Wang
authors.forename: Sherif I
authors.initials: SI
authors.lastname: Elshahawi
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Shaaban
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Larissa V
authors.initials: LV
authors.lastname: Ponomareva
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Copley
authors.forename: James C
authors.initials: JC
authors.lastname: Hower
authors.forename: Chang-Guo
authors.initials: CG
authors.lastname: Zhan
authors.forename: Madan K
authors.initials: MK
authors.lastname: Kharel
authors.forename: Jon S
authors.initials: JS
authors.lastname: Thorson
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007629:Kentucky; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D000095622:Benzoisochromanequinones
chemical_list: D000935:Antifungal Agents; D009285:Naphthoquinones; D061065:Polyketides; C000589878:ruthmycin; C018066:frenolicin B; D000095622:Benzoisochromanequinones