title: Glucocorticosteroid in treatment of severe pneumonia.
abstract: Airway diseases such as pneumonia constitute a major health burden on a global scale; untreated pneumonia may develop to severe pneumonia and consequently lead to to fatal episodes of mortality and morbidity. The balance between inflammatory mediators is key for the outcome of the pulmonary infection; elimination of invading pathogen was marked by the release of cytokines and other inflammatory mediators from alveolar macrophages and glucocorticoid steroids (GCs) acting on the inflammatory component. Treatments of severe pneumonia with GCs have been developing for years with inconclusive results. In many cases GCs have been administered empirically without clinical evidence. Recent studies assess beneficial impact on treatment of severe pneumonia by suggesting specific dosage, period of administration, and tapered dosage.
authors.affiliation: Department of Respiratory Medicine, Huadong Hospital, Shanghai Medical School of Fudan University, 221 Yananxi Road, Shanghai 200040, China.
authors.forename: Felinda
authors.initials: F
authors.lastname: Ariani
authors.affiliation: Department of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China.
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Shanghai Medical School of Fudan University, 180 Fenglin Road, Shanghai 200032, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Department of Respiratory Medicine, Huadong Hospital, Shanghai Medical School of Fudan University, 221 Yananxi Road, Shanghai 200040, China.
authors.forename: Jieming
authors.initials: J
authors.lastname: Qu
mesh_terms: D016207:Cytokines / Q000502:physiology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy* / Q000276:immunology; D012128:Respiratory Distress Syndrome / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy
chemical_list: D016207:Cytokines; D005938:Glucocorticoids