title: The seventh pandemic Vibrio cholerae O1 El Tor isolate in China has undergone genetic shifts.
abstract: A total of 330 clinical Vibrio cholerae O1 serogroups from China dating between 1961 and 2010 were investigated. By phenotypic biotyping and genetic analysis, during the seventh pandemic of V. cholerae O1 in China, the isolates of hybrid biotype (mixed classical phenotypes) were present during the entire1961-2010 period, while El Tor genetic shifts appeared in 1992 and replaced the prototype El Tor from 2002 to 2010.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Li
authors.forename: Weili
authors.initials: W
authors.lastname: Liang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
authors.forename: Duochun
authors.initials: D
authors.lastname: Wang
mesh_terms: D015373:Bacterial Typing Techniques; D002681:China / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D058873:Pandemics; D041241:Vibrio cholerae O1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification