title: [Relation of reinfused hematopoietic stem cell volume and recipient's leukocyte count at reinfusion with prognosis of disease in allo-hematopoietic stem cell transplantation].
abstract: This study was aimed to investigate the relation of reinfused hematopoietic stem cell volume and recipient's leukocyte count at reinfusion with prognosis of disease in allo-hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 37 patients received allo-HSCT in our hospital were analyzed retrospectively. The 37 patients were divided into agranulocytosis and non-agranulocytosis groups according to the recipient's leukocyte count at reinfusion, and were divided into the high dose and low dose groups according to the median number of reinfused mononuclear cells (MNC) and CD34(+) cells. Then, hematopoietic reconstructions,GVHD, relapse and death rates of patients were compared. The results showed that the hematopoietic reconstruction of patients in non-agranulocytosis group and high dose MNC group were earlier than that in agranulocytosis group and low dose MNC group. There was no significant difference of hematopoietic reconstruction between the groups of high dose CD34(+) cells and low dose CD34(+) cells. The GVHD incidence was higher in high dose MNC group and non-agranulocytosis group than that in low dose MNC group and agranulocytosis group (P < 0.05). There were no statistical differences of relapsed and death rates between different reinfused number of HSC and recipient's leukocyte count at reinfusion.It is concluded that the infused MNC number and the recipient's leukocyte count at reinfusion in allo-HSCT correlated with hematopoietic reconstruction, the GVHD incidence is high in high dose MNC and non-agranulocytosis groups, the reinfused HSC volume and the recipient's leukocyte count at reinfusion not significantly relate with relapse and death rates.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China. E-mail:zhangmei@medmail.com.cn.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: He
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Jie-Ying
authors.initials: JY
authors.lastname: Xi
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Meng-Chang
authors.initials: MC
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Chen
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Hua-Sheng
authors.initials: HS
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Cai-Li
authors.initials: CL
authors.lastname: Guo
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi Province, China.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult