title: Rational considerations about development of live attenuated Yersinia pestis vaccines.
abstract: The risk of plague as a bioweapon has prompted increasing research efforts to develop plague vaccines due to its extreme virulence and the ease of its transmission. Subunit vaccines that contain F1 and LcrV antigens of Y. pestis have been tested for safety and immunogenicity, but doubts have been raised about whether subunit vaccines that engender antibody responses will protect against pneumonic plague, which requires both humeral and cellular immune responses for protection. The live, attenuated vaccine EV76, a pgm locus deficient Y. pestis strain, has been used for a long time in the Former Soviet Union and some Asian countries, but is not commercially available in the US and Europe due to safety concerns. However, the live attenuated Y. pestis vaccines are still considered to be the most effective way to prevent plague. In this review, we present our opinions about rationally creating live, safe and immunogenic Y. pestis vaccines with potential use for human based on established researches.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Center for Infectious Diseases and Vaccinology at Biodesign Institute, P.O. BOX 875401 Tempe, AZ 85287-5401, USA. wei.sun.1@asu.edu.
authors.forename: Roy
authors.initials: R
authors.lastname: Curtiss
mesh_terms: D000818:Animals; D035843:Biomedical Research; D055808:Drug Discovery; D006801:Humans; D007113:Immunity, Innate; D010930:Plague / Q000276:immunology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology; D014774:Virulence; D015010:Yersinia pestis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D010931:Plague Vaccine; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit