title: [The hepatitis A virus: structural and functional organization of the genome, its molecular diagnostic value and cultivation].
abstract: The analysis of recently published data on hepatitis A virus (HAV) genome clinical features, molecular diagnostic value and cell culture propagation are reviewed. The growing need in the study of the genetic diversity of HAV isolates and the search of its possible new antigenic variants are underlined. The results of the cultivation of different HAV strains are analyzed for possible application in vaccine and diagnostic kit production.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bondarenko
authors.forename: V A
authors.initials: VA
authors.lastname: Ternovoĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
mesh_terms: D000818:Animals; D014644:Genetic Variation; D016679:Genome, Viral; D006506:Hepatitis A / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D035921:Hepatitis A Antigens / Q000235:genetics / Q000378:metabolism; D030041:Hepatitis A virus / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D011933:Reagent Kits, Diagnostic
chemical_list: D035921:Hepatitis A Antigens; D011933:Reagent Kits, Diagnostic