title: Longitudinal trajectories of everyday function by diagnostic status.
abstract: Generalized linear mixed models were used to examine longitudinal trajectories of everyday functional limitations by diagnostic stability/progression. Older adults (N = 384) were followed an average 3.6 years; participants were grouped by diagnosis at study baseline and last follow-up (normal cognition, Mild Cognitive Impairment, or dementia at each time point). At study baseline there were clear group differences; most notably among participants initially characterized as cognitively normal, those who developed Mild Cognitive Impairment or dementia over follow-up already demonstrated greater functional impairment compared with those who remained cognitively normal. Change in functional impairment progressed slowly in the early disease groups, but showed an accelerated worsening in those converting to dementia.
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Sarah Tomaszewski
authors.initials: ST
authors.lastname: Farias
authors.affiliation: Department of Public Health, Division of Biostatistics School of Medicine University of California, Davis.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Chou
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Harvey
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Dan
authors.initials: D
authors.lastname: Mungas
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Bruce
authors.initials: B
authors.lastname: Reed
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.affiliation: Department of Neurology, University of California, Davis.
authors.forename: Lovingly Quitania
authors.initials: LQ
authors.lastname: Park
authors.affiliation: Department of Public Health, Division of Biostatistics, University of California, Davis.
authors.forename: Laurel
authors.initials: L
authors.lastname: Beckett
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology; D002140:California; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D018450:Disease Progression; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales