title: [Last updates about amniotic fluid embolism and a case report].
abstract: Amniotic fluid embolism (AFE) is a rare complication of pregnancy, which, in France, is the second leading cause of maternal mortality. It results from the passage of amniotic fluid into the maternal circulation, but mechanisms leading to clinical signs are not yet clearly identified. After a literature review, we report on the case of a 34 years old patient occurred during labor. Laboratory tests were performed during acute phase to diagnose coagulopathy and to monitor vital parameters. Further laboratory tests were conducted to support the diagnosis: cytology, study of insulin-like growth factor-binding protein 1, tryptase and alpha-foetoprotein. Performances and place of these laboratory tests must be precised as no specific test can attest the diagnosis.
authors.affiliation: Service de biochimie métabolique, Groupe hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Rosain
authors.affiliation: Département d'anesthésie-réanimation, Groupe hospitalier Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris-6, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Le Saché
authors.affiliation: Département d'anesthésie-réanimation, Groupe hospitalier Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris-6, Paris, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Birenbaum
authors.affiliation: Service de biologie fœto-maternelle, Hôpital de la Croix-Rousse, Lyon.
authors.forename: Catherine
authors.initials: C
authors.lastname: Boisson-Gaudin
authors.affiliation: Service de biochimie endocrinienne et oncologique, Groupe hospitalier Pitié-Salpêtrière, Paris, France, Unité pédagogique de biochimie, Faculté des sciences pharmaceutiques et biologiques, Paris Descartes Sorbonne Paris Cité, Paris, France.
authors.forename: Maguy
authors.initials: M
authors.lastname: Bernard
mesh_terms: D000328:Adult; D004619:Embolism, Amniotic Fluid / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005165:Factor V / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005602:France / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D007044:Hysterectomy; D063130:Maternal Death; D009154:Mutation; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000601:surgery; D011247:Pregnancy; D020521:Stroke / Q000175:diagnosis / Q000209:etiology
chemical_list: D005165:Factor V
keywords: alpha-foetoprotein; amniotic fluid embolism; insulin-like growth factor binding protein-1; pregnancy; tryptase