title: Choriocarcinoma-like tumor in a potbellied pig (Sus scrofa).
abstract: A uterine tumor, with histological and immunohistochemical features consistent with those of human choriocarcinoma, was identified in a 10-year-old unmated female pot-bellied pig (Sus scrofa). The tumor showed biphasic proliferation of cytotrophoblast-like cells and syncytiotrophoblast-like cells. Immunohistochemically, the syncytiotrophoblast-like cells were positive for human chorionic gonadotropin, and both types of cells were positive for cytokeratin and negative for vimentin, octamer-binding transcription factor 4, and α-fetoprotein. Because syncytiotrophoblasts are absent in the normal porcine placenta, the tumor was diagnosed as a choriocarcinoma-like tumor.
authors.affiliation: 1Akihiro Hirata, Division of Animal Experiment, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194. Japan. akatsuki@gifu-u.ac.jp.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirata
authors.forename: Aya
authors.initials: A
authors.lastname: Miyazaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakai
authors.forename: Nanae
authors.initials: N
authors.lastname: Imada
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kitani
authors.forename: Hideki
authors.initials: H
authors.lastname: Nikami
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002822:Choriocarcinoma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: Choriocarcinoma; potbellied pigs; trophoblast; uterus