title: Two new triterpenoids from Gelsemium elegans and Aglaia odorata.
abstract: Eleganoside A (1) and odoratanone A (15), a triterpenoid trisaccharide glycoside and a nortriterpenoid, together with twelve known compounds (2-13) and a mixture of cerebrosides (14) were isolated from Gelsemium elegans and Aglaia odorata. Their structures were elucidated by extensive spectroscopic and spectrometric analysis. Eleganoside A (1) features a 3-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glucopyranosyl (1-->4)-beta-D-glucopyranoside of a peculiar 3,16-dihydroxyl-lanosta-8,24-dien-26-oic acid triterpenoid skeleton, and odoratanone A (15) is a 29-norcycloartane-type triterpenoid bearing an unusual five-membered methyl acetal ring. Anti-acetylcholinesterase/butyrylcholinesterase (AChE/BChE) assay indicated that at 50 microM, ethyl caffeate (5) was promising as a dual inhibitor of AChE and BChE, and paeonol (3) and 24-hydroperoxy-24-vinylcholesterol (9) exhibited BChE-selective inhibition.
authors.affiliation: Key Laboratory of Tropical Forest Ecology, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Tropical Forest Ecology, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
authors.forename: You-Kai
authors.initials: YK
authors.lastname: Xu
authors.affiliation: Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang 550004, Guizhuo, China.
authors.forename: Shang-Gao
authors.initials: SG
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.affiliation: Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Na
mesh_terms: D031602:Aglaia / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D031450:Gelsemium / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002800:Cholinesterase Inhibitors; D014315:Triterpenes; C585938:eleganoside A; C585939:odoratanone A