title: Association between C-reactive protein gene +1059 G/C polymorphism and the risk of coronary heart disease: a meta-analysis.
abstract: BACKGROUND
  C-reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk, but the results remain inconclusive. This meta-analysis was therefore conducted to clarify these controversies.
  
  
  METHODS
  A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk. All the related studies were further strictly selected according to the inclusion criteria. Meta-analysis was performed with STATA 10.1 (StataCorp, USA). The association was assessed by odds ratio (OR) and 95% confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias.
  
  
  RESULTS
  This meta-analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs. G/G: OR = 1.01, 95% CI = 0.81-1.25, P = 0.96; for C/C vs. C/G+G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C/C vs. G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C allele vs. G allele: OR = 1.01, 95% CI = 0.81-1.24, P = 0.96). However, in the subgroup analysis by ethnicity, the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs. G/G: OR = 2.54, 95% CI = 1.13-5.72, P = 0.02; C/C vs. C/G+G/G: OR = 2.45, 95% CI = 1.09-5.51, P = 0.03), but not among Asians and Africans (P > 0.05).
  
  
  CONCLUSIONS
  CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China.
authors.forename: Cong-Sheng
authors.initials: CS
authors.lastname: Li
authors.affiliation: Department of Dermatology, Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China.
authors.forename: Bi-Rong
authors.initials: BR
authors.lastname: Guo
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Medicine, Human Genetics, Epidemiology and Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada. Email: hou.zheng@mail.mcgill.ca.
authors.forename: Hou-Feng
authors.initials: HF
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. Email: wal@ah.edu.cn.
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Wang
mesh_terms: D002097:C-Reactive Protein / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D002097:C-Reactive Protein