title: An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates.
abstract: A flexible and integrated flow-chemistry-synthesis-purification compound-generation and sample-management platform has been developed to accelerate the production of small-molecule organic-compound drug candidates in pharmaceutical research. Central to the integrated system is a Mitsubishi robot, which hands off samples throughout the process to the next station, including synthesis and purification, sample dispensing for purity and quantification analysis, dry-down, and aliquot generation.
authors.affiliation: 1AbbVie Inc., North Chicago, IL, USA.
authors.forename: J David
authors.initials: JD
authors.lastname: Sutherland
authors.forename: Noah P
authors.initials: NP
authors.lastname: Tu
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Nemcek
authors.forename: Philip A
authors.initials: PA
authors.lastname: Searle
authors.forename: Jill E
authors.initials: JE
authors.lastname: Hochlowski
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
authors.forename: Jeffrey Y
authors.initials: JY
authors.lastname: Pan
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods*; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D013048:Specimen Handling / Q000379:methods*
chemical_list: D009930:Organic Chemicals
keywords: Pharmaceutical research; automation; drug discovery; flow chemistry; high-performance liquid chromatography (HPLC); purification; synthesis