title: [Changes in epidermal growth factor concentrations in neonates with late-onset breast milk jaundice after stopping breast feeding].
abstract: OBJECTIVE
  To investigate the changes in epidermal growth factor (EGF) concentrations in infants' serum and breast milk in neonates with late-onset breast milk jaundice after stopping breast feeding.
  
  
  METHODS
  Thirty full-term infants with late-onset breast milk jaundice were included in the study. Infants' serum and breast milk were collected before and 72 hours after stopping breast feeding, and the total bilirubin and EGF concentrations in infants' serum and EGF concentration in breast milk were measured respectively.
  
  
  RESULTS
  At 72 hours after stopping breast feeding, the total bilirubin and EGF concentrations in infants' serum were significantly decreased (P<0.05), but the EGF concentration in breast milk did not show significant change (P>0.05).
  
  
  CONCLUSIONS
  After stopping breast feeding, the neonates with late-onset breast milk jaundice show significant decreases in serum EGF concentration, but the EGF concentration in breast milk shows no significant change. The role and action mechanism of EGF in late-onset breast milk jaundice need further study.
authors.affiliation: Center for Diagnosis and Treatment of Neonatal Diseases, 302 Hospital of People's Liberation Army, Beijing 100039, China. doctor1966@sina.com.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Xiao
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Wang
mesh_terms: D001663:Bilirubin / Q000097:blood; D001942:Breast Feeding; D004815:Epidermal Growth Factor / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology*; D008297:Male; D008895:Milk, Human / Q000737:chemistry*
chemical_list: D004815:Epidermal Growth Factor; D001663:Bilirubin