title: Asymmetric synthesis of 4,1-benzoxazepine-2,5-diones--effect of the halogen of (2S)-α-haloacids.
abstract: Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively.
authors.forename: Syeda Laila
authors.initials: SL
authors.lastname: Rubab
authors.forename: Bushra
authors.initials: B
authors.lastname: Nisar
authors.affiliation: Ibn-e-Sina Block, Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan. roofichemist2012@gmail.com.
authors.forename: Abdul Rauf
authors.initials: AR
authors.lastname: Raza
authors.affiliation: Ibn-e-Sina Block, Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan. nullah@kfupm.edu.sa.
authors.forename: Nisar
authors.initials: N
authors.lastname: Ullah
authors.forename: Muhammad Nawaz
authors.initials: MN
authors.lastname: Tahir
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006219:Halogens / Q000737:chemistry*; D008968:Molecular Conformation; D010077:Oxazepines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C453003:4,1-benzoxazepine; D006219:Halogens; D010077:Oxazepines