title: Potential of resveratrol in the treatment of heart failure.
abstract: The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compounds have recently received increased attention in medical research. In this group, one of the most studied has been resveratrol (3,5,4,-trihydroxystilbene), a polyphenol, which is found predominantly in grapes and berries. Over the past two decades, researchers have studied the ability of resveratrol to prevent or reverse the development of abnormalities in heart structure and function in animal models of heart disease and heart failure. The results from animal studies have been promising, and very recently, this knowledge has been translated into examining the efficacy of resveratrol in humans with heart disease/failure. In this review we will discuss the current status of resveratrol research on cardioprotection.
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada; Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
authors.forename: Pema
authors.initials: P
authors.lastname: Raj
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada; Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
authors.forename: Xavier Lieben
authors.initials: XL
authors.lastname: Louis
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada; Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
authors.forename: Sijo Joseph
authors.initials: SJ
authors.lastname: Thandapilly
authors.affiliation: Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Movahed
authors.affiliation: Section of Cardiology, Department of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
authors.forename: Shelley
authors.initials: S
authors.lastname: Zieroth
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada; Agriculture and Agri-Food Canada, Winnipeg, MB R3T 2M9, Canada; Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Electronic address: tnetticadan@sbrc.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Netticadan
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry
chemical_list: D002316:Cardiotonic Agents; D013267:Stilbenes; D000077185:Resveratrol
keywords: Cardioprotection; Heart disease; Heart failure; Polyphenols; Resveratrol