title: Genetic association between p53 codon 72 polymorphism and risk of cutaneous squamous cell carcinoma.
abstract: This study was designed to obtain a conclusive result about the relevance of p53 codon 72 polymorphism to the risk of cutaneous squamous cell carcinoma (SCC). We performed an updated meta-analysis of 3,792 subjects (1,349 cancer cases and 2,443 controls) to summarize the data available for p53 codon 72 polymorphism and SCC risk. The association was estimated by odds ratios (ORs) with 95% confidence intervals (CIs). The meta-analysis showed no statistical significance for SCC risk associated with any of the genetic models of p53 codon 72 polymorphism. The analyses by ethnic subgroup also failed to produce significant associations. This study suggests that p53 codon 72 polymorphism does not appear to represent a significant susceptibility factor for SCC in Caucasians.
authors.affiliation: Department of Plastic and Cosmetic Surgery, XinQiao Hospital, The Third Military Medical University, ChongQing, 400037, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Lei
authors.forename: ZhengYing
authors.initials: Z
authors.lastname: Pan
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: TongChun
authors.initials: T
authors.lastname: Mao
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Dongli
authors.initials: D
authors.lastname: Fan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D003062:Codon; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53