title: Phylogenetic and molecular characterization of chicken anemia virus in southern China from 2011 to 2012.
abstract: Chicken anemia virus (CAV) is an important pathogen that causes severe immunosuppression in young chickens. We have characterized 13 CAVs isolated from different commercial farms in southern China between 2011 and 2012. We discovered 92 variable residues compared to 37 other CAV complete genome sequences from other parts of the world listed in GenBank; these residues have not been previously observed. All of the Chinese CAV genomes that were characterized in this study had a glutamine at position 394, a hallmark of highly pathogenic CAVs. We also discovered that intra-group genetic recombination plays a role in generating genetic diversity in natural populations of CAV. The GD-J-12 isolate was a possible recombinant between GD-C-12 and GD-M-12 in the genomic region that encompassed both the coding and non-coding regions.
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Xinheng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Yuanjia
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Boliang
authors.initials: B
authors.lastname: Wu
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Sun
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Ma
authors.affiliation: 1] College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China [2] Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, China.
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000818:Animals; D017727:Chicken anemia virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002645:Chickens; D002681:China; D018173:Circoviridae Infections / Q000662:veterinary*; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology*; D011995:Recombination, Genetic
chemical_list: D004279:DNA, Viral