title: Mucormycosis: a rare complication of an amputation.
abstract: Mucormycosis is a rare but serious opportunistic fungal infection. Several clinical forms have been described, including cutaneous localization that is frequently associated with soft tissue trauma or burns. We report a case of cutaneous mucormycosis in a diabetic patient with severe occlusive arterial disease. The diagnosis was made early with mold growth on an amputation wound and the presence of nonseptate hyphae on direct microscopic examination, later identified on culture as Lichtheimia ramosa. Aggressive treatment, including the control of underlying diseases, systemic and local amphotericin B, and extensive surgical debridement permitted successful outcomes.
authors.affiliation: Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées Val de Grâce, Paris, France. Electronic address: arthusdechaumont@gmail.com.
authors.forename: Arthus
authors.initials: A
authors.lastname: de Chaumont
authors.affiliation: Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées Val de Grâce, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Pierret
authors.affiliation: Service de Biologie, Hôpital d'Instruction des Armées Bégin, Saint Mandé, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Janvier
authors.affiliation: Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées Val de Grâce, Paris, France.
authors.forename: Yvain
authors.initials: Y
authors.lastname: Goudard
authors.affiliation: Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées Val de Grâce, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: de Kerangal
authors.affiliation: Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées Val de Grâce, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Chapuis
mesh_terms: D000369:Aged, 80 and over; D000666:Amphotericin B / Q000008:administration & dosage; D000671:Amputation, Surgical / Q000009:adverse effects*; D000672:Amputation Stumps / Q000382:microbiology* / Q000601:surgery; D000935:Antifungal Agents / Q000008:administration & dosage; D003646:Debridement; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D009090:Mucorales / Q000302:isolation & purification*; D009091:Mucormycosis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000601:surgery*; D012086:Reoperation; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B