title: A rapid one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives using Brønsted-acidic ionic liquid as catalyst.
abstract: Pyrido[2,3-d]pyrimidine derivatives were synthesized regioselectivly in good to high yields by one-pot three-component condensation of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, aromatic aldehydes and ethylcyanoacetate or meldrum's acid using 1,2-dimethyl-N-butanesulfonic acid imidazolium hydrogen sulfate ([DMBSI]HSO4) Brønsted-acidic ionic liquid as catalyst. Solvent-free mild reaction conditions, short reaction times, easy work-up, and reusability of the catalyst are the main advantages of this protocol.
authors.forename: Roghayeh Hossein
authors.initials: RH
authors.lastname: Nia
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Mamaghani
authors.forename: Khalil
authors.initials: K
authors.lastname: Tabatabaeian
authors.forename: Farhad
authors.initials: F
authors.lastname: Shirini
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rassa
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis*
chemical_list: D000143:Acids; D052578:Ionic Liquids; D011743:Pyrimidines