title: Selective hydrolysis of flavonoid glycosides by Curvularia lunata.
abstract: Twelve flavonoid glycosides were involved in the biotransformation of the glycosyl moieties by Curvularia lunata 3.4381, and the products were analyzed by UPLC/PDA-Q-TOF-MS(E). Curvularia lunata displayed hydrolyzing activities on the terminal Rha or Glc units of some flavonoid glycosides. Terminal Rha with a 1 → 2 linkage of isorhamnetin-3-O-neohesperidoside and typhaneoside could be hydrolyzed by Curvularia lunata, but terminal Rha with a 1 → 6 linkage of rutin, typhaneoside, and quercetin-3-O-apiosyl-(1 → 2)-[rhamnosyl-(1 → 6)]-glucoside could not be hydrolyzed. Curvularia lunata could also hydrolyze the Glc of icariin, floramanoside B, and naringin. This is the first report of the hydrolysis of glycosyl units of flavonoid glycosides by Curvularia lunata. A new way to convert naringin to naringenin was found in this research.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Liu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: He-Shui
authors.initials: HS
authors.lastname: Yu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Kang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Xiong
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Li
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: mabaiping@sina.com.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry*; D006868:Hydrolysis; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: D005419:Flavonoids; D005960:Glucosides
keywords: Biotransformation; Curvularia lunata; Flavonoid glycosides; Glucosyl; Rhamnosyl; Selective Hydrolysis