title: Potent phosphatidylinositol 3-kinase inhibitors and their biology.
abstract: The Phosphoinositide 3-kinase (PI3k) is an important regulator of intracellular signalling pathways, like cell proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k's pathway is frequently up-regulated in human cancers, thus inhibition of PI3k's is a promising approach for cancer therapy. Many potent PI3k's inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482 and others are natural products etc.
authors.forename: Mukesh Chandra
authors.initials: MC
authors.lastname: Joshi
authors.forename: Krishan
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India. mukeshjoshi21@gmail.com.
authors.forename: Vikrant
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D000081082:Phosphoinositide-3 Kinase Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D000081082:Phosphoinositide-3 Kinase Inhibitors