title: Biological activities and pharmacokinetics of praeruptorins from Peucedanum species: a systematic review.
abstract: Praeruptorins belonging to the angular-type pyranocoumarins are bioactive constituents that have been isolated from some Peucedanum species such as P. praeruptorum, which is used in traditional Chinese medicine for treatment of cold, cough, upper respiratory infections, and so forth. Many reports have demonstrated that the beneficial pharmacological effects of P. praeruptorum root on cardiovascular, pulmonary, immune, and nervous system diseases were attributed to the presence of praeruptorins. The aim of this review is to explain the recent efforts of scientists in pharmacological screening of natural and synthetic praeruptorin derivatives, studying the mechanisms of some praeruptorins action, pharmacokinetics, toxicity, and relevant structure-activity relationships. Based on reported data about the pharmacological properties of praeruptorins and semisynthetic derivatives of them, it is hopeful that in the near future more studies focus on the discovery of the new application and therapeutic uses of these bioactive compounds and understanding the specific mechanisms of them. The present discusses the reports on molecular and biological activities of praeruptorins of the genus Peucedanum, from 1976 onwards.
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 16th Azar Street, P.O. Box 14155-6451, Tehran 14176, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Sarkhail
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 16th Azar Street, P.O. Box 14155-6451, Tehran 14176, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 16th Azar Street, P.O. Box 14155-6451, Tehran 14176, Iran.
authors.forename: Pantea
authors.initials: P
authors.lastname: Sarkheil
mesh_terms: D019661:Apiaceae / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000627:therapeutic use*; D017679:Cryotherapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; C441070:praeruptorin A