title: Nickel trafficking system responsible for urease maturation in Helicobacter pylori.
abstract: Helicobacter pylori (H. pylori) is a common human pathogen responsible for various gastric diseases. This bacterium relies on the production of urease and hydrogenase to inhabit the acidic environment of the stomach. Nickel is an essential cofactor for urease and hydrogenase. H. pylori has to uptake sufficient nickel ions for the maturation of urease, and on the other way, to prevent the toxic effects of excessive nickel ions. Therefore, H. pylori has to strike a delicate balance between the import of nickel ions, its efficient intracellular storage, and delivery to nickel-dependent metalloenzymes when required. The assembly and maturation of the urease enzyme is a complex and timely ordered process, requiring various regulatory, uptake, chaperone and accessory proteins. In this review, we focus on several nickel trafficking proteins involved in urease maturation: NikR, NixA, HypAB, UreEFGH, HspA, Hpn and Hpnl. The work will deepen our understanding of how this pathogenic bacterium adapts to severe habitant environments in the host.
authors.affiliation: Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao, Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China.
authors.forename: Rui-Guang
authors.initials: RG
authors.lastname: Ge
authors.affiliation: Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao, Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China.
authors.forename: Dong-Xian
authors.initials: DX
authors.lastname: Wang
authors.affiliation: Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao, Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China.
authors.forename: Ming-Cong
authors.initials: MC
authors.lastname: Hao
authors.affiliation: Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao, Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Sun
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000201:enzymology* / Q000472:pathogenicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D018832:Molecular Chaperones; D009532:Nickel / Q000378:metabolism*; D011487:Protein Conformation; D012097:Repressor Proteins / Q000378:metabolism; D013270:Stomach / Q000382:microbiology*; D014510:Urease / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D008667:Metalloproteins; D018832:Molecular Chaperones; C523724:NikR protein, Helicobacter pylori; D012097:Repressor Proteins; D009532:Nickel; D014510:Urease
keywords: Helicobacter pylori; Histidine-rich protein; NikR; NixA; Urease