title: Postcataract surgery endophthalmitis after introduction of the ESCRS protocol: a 5-year study.
abstract: OBJECTIVE
  To present the results of a retrospective comparative unicentric institutional study of the incidence of postcataract surgery endophthalmitis before and after the introduction of the European Society of Cataract and Refractive Surgeons (ESCRS) protocol in 2007 in our department.
  
  
  METHODS
  This study included 15,689 eyes of patients undergoing cataract surgery between 2005 and 2011. Surgeries were performed by 9 different surgeons. After June 2007, the ESCRS protocol was introduced, and all patients underwent intracameral injection of 1 mg of cefuroxime (10 mg/mL) at the end of cataract surgery. Cefuroxime was prepared prior to surgery in the operating room. All patients were observed between 6 weeks and 3 months after surgery.
  
  
  RESULTS
  Between January 2005 and June 2007, before the introduction of the ESCRS protocol in our department, 2299 patients underwent cataract surgery and there were 6 cases of postoperative endophthalmitis (0.26%). After the introduction of the protocol, 13,390 surgeries were performed and there were no cases of endophthalmitis.
  
  
  CONCLUSIONS
  Postoperative endophthalmitis is one of the most devastating cataract surgery complications. Our results provide strong evidence of the utility of cefuroxime as prophylaxis of endophthalmitis after cataract surgery.
authors.affiliation: Department of Ophthalmology, Hospital Center Leiria, Leiria - Portugal.
authors.forename: Diana
authors.initials: D
authors.lastname: Beselga
authors.forename: António
authors.initials: A
authors.lastname: Campos
authors.forename: Miguel
authors.initials: M
authors.lastname: Castro
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernandes
authors.forename: Fausto
authors.initials: F
authors.lastname: Carvalheira
authors.forename: Sónia
authors.initials: S
authors.lastname: Campos
authors.forename: Sílvia
authors.initials: S
authors.lastname: Mendes
authors.forename: Arminda
authors.initials: A
authors.lastname: Neves
authors.forename: Joana
authors.initials: J
authors.lastname: Campos
authors.forename: Luís
authors.initials: L
authors.lastname: Violante
authors.forename: João C
authors.initials: JC
authors.lastname: Sousa
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000187:drug effects / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction; D002444:Cefuroxime / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D007267:Injections; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime