title: The usefulness of the sum of relative enhancement ratio in making a differential diagnosis of hepatocellular carcinoma from cirrhosis-related nodules.
abstract: OBJECTIVE
  To estimate the diagnostic accuracy of the sum of relative enhancement ratio (sRER) in making a differential diagnosis of hepatocellular carcinoma (HCC) from benign cirrhosis-related nodules.
  
  
  METHODS
  Eighteen benign cirrhosis-related nodules and 18 HCCs were evaluated. Three radiologists independently reviewed computed tomography images using visual assessment and sRER. sRER was estimated by adding region-of-interest measurement in the arterial phase and the delayed phase. Diagnostic performance and accuracy were evaluated.
  
  
  RESULTS
  The mean values of sRER were significantly higher in HCCs than in benign cirrhosis-related nodules.
  
  
  CONCLUSIONS
  The sRER method improved diagnostic accuracy of differentiating HCCs from benign cirrhosis-related nodules.
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 634-18 Keumam-Dong, Deokjin-gu, Chonju-shi, Chonbuk 561-712 South Korea.
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 634-18 Keumam-Dong, Deokjin-gu, Chonju-shi, Chonbuk 561-712 South Korea; Research Institute of Radiation Medicine, Chonbuk National University Medical School and Hospital, 634-18 Keumam-Dong, Deokjin-gu, Chonju-shi, Chonbuk 561-712 South Korea. Electronic address: pichgo@gmail.com.
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Song
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 634-18 Keumam-Dong, Deokjin-gu, Chonju-shi, Chonbuk 561-712 South Korea; Research Institute of Radiation Medicine, Chonbuk National University Medical School and Hospital, 634-18 Keumam-Dong, Deokjin-gu, Chonju-shi, Chonbuk 561-712 South Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Han
mesh_terms: D000368:Aged; D019540:Area Under Curve; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: Computed tomography; Hepatocellular carcinoma; Hepatocellular nodule