title: Phenytoin-induced cerebellar atrophy in an epileptic boy.
abstract: Epilepsy is an important health problem due to its high prevalence and potential for causing long-term morbidity. It is commonly treated in children with phenytoin sodium. It has wide pharmacokinetic variability and a narrow therapeutic range that leads to toxicity. Here, we report a case of phenytoin-induced cerebellar atrophy in a 16-year-old epileptic boy who presented to the hospital with a viral infection.
authors.affiliation: Department of Neurology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
authors.forename: Nithin
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
authors.forename: Ananya
authors.initials: A
authors.lastname: Chakraborty
authors.affiliation: Department of Pharmacology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
authors.forename: Swaroop H
authors.initials: SH
authors.lastname: Suresh
authors.affiliation: Department of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
authors.forename: Sashidharan
authors.initials: S
authors.lastname: Basappaji
authors.affiliation: Department of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
authors.forename: Anand L
authors.initials: AL
authors.lastname: Betdur
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002531:Cerebellum / Q000473:pathology*; D004827:Epilepsy / Q000150:complications*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin
keywords: Adverse drug reaction; antiepileptic drugs; antiseizure drugs; cerebellar atrophy; phenytoin