title: High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats.
abstract: In a recent study, we obtained some evidences that probiotic strain Lactobacillus affects the autonomic nerve activities and regulates blood glucose and cardiovascular function. In the study presented here, we found that long-term ingestion of the lactobacillus strain Lactobacillus paracasei ST11 (NCC2461) reduced body weight and abdominal fat weight. To investigate possible role of autonomic nerves in anti-obesity action of NCC2461, we examined the effects of intraduodenal (ID) injection of the lactobacillus strain L. paracasei ST11 (NCC2461) on sympathetic nerve activity innervating white adipose tissue (WAT-SNA) in urethane-anesthetized rats, and found that it accelerated WAT-SNA. Moreover, intraduodenal (ID) injection of NCC2461 increased in sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) and decreased in hepatic vagal nerve activity (HVNA). In addition, using conscious rats, we examined the effects of intra-gastric (IG) injection of NCC2461 on lipolysis and BAT thermogenesis, and observed that it clearly elevated the plasma FFA level, BAT temperature and abdominal temperature. Thus, these data suggest that the NCC2461 affects autonomic nerves, enhances lipolysis, and reduces body weight in rats.:
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan. Electronic address:mtanida@sk.ritsumei.ac.jp.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanida
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Jiao
authors.initials: J
authors.lastname: Shen
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Maeda
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horii
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamano
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Fukushima
authors.affiliation: ANBAS Corporation, 4th Floor Nakajima-Building, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagai