title: Methyl angolensate and mexicanolide-type limonoids from the seeds of Cipadessa baccifera.
abstract: Six new methyl angolensate type (1-6) and three new mexicanolide-type (7-9) limonoids, along with six known limonoids (10-15), were isolated from the seeds of Cipadessa baccifera. The structures of all these compounds were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structures of 11 and 13 were further confirmed by a single crystal X-ray diffraction analysis, which are reported for the first time. The cytotoxic activities of these isolates were also studied against A549, MCF7, ME-180, HT-29, B-16, ACHN cancer cell lines using MTT assay, and results indicated that compounds 4, 10, and 14 displayed potent cytotoxic activity against B-16, ACHN cell lines with an IC50 values of 8.51 and 7.0 μg/mL, respectively.
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: Bandi
authors.initials: B
authors.lastname: Siva
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: B
authors.initials: B
authors.lastname: Poornima
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: A
authors.initials: A
authors.lastname: Venkanna
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: K Rajendra
authors.initials: KR
authors.lastname: Prasad
authors.affiliation: Center for X-Ray Crystallography, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.affiliation: Division of Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: V Lakshma
authors.initials: VL
authors.lastname: Nayak
authors.affiliation: Division of Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India.
authors.forename: Sistla
authors.initials: S
authors.lastname: Ramakrishna
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India. Electronic address: suresh@iict.res.in.
authors.forename: K Suresh
authors.initials: KS
authors.lastname: Babu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; D014315:Triterpenes; C092741:methyl angolensate
keywords: Cancer cell lines; Cipadessa baccifera; Cytotoxic activity; Limonoids