title: [Autophagy and immune response].
abstract: Autophagy is a complex process in which cell homeostasis of proteins, organelles, exocitic and endocitic vacuoles are controlled. There is a direct link between autophagy and cell death with antigen processing, generation of inflammatory response and immune response. In different diseases, deficiencies in autophagy have been reported. It has been proposed that in early stages of cancer, autophagy is capable of inducing cell death; however, in agresive tumors and metastasis, the process is responsible for pharmacologic resistance and tumor survival. More research has to be done in order to allow us to understand the process and generate therapeutic options in different pathologies important for the human being.
authors.affiliation: Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: Maria Johanna
authors.initials: MJ
authors.lastname: Peña-Sanoja
authors.affiliation: Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: Juan Bautista
authors.initials: JB
authors.lastname: De Sanctis
mesh_terms: D056704:Adaptive Immunity; D017951:Antigen Presentation; D001343:Autophagy / Q000276:immunology / Q000502:physiology*; D006680:HLA Antigens / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D006680:HLA Antigens; D009363:Neoplasm Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53