title: Natural cytotoxicity receptors and their ligands.
abstract: Natural killer (NK) cells are innate lymphoid cells (ILCs) that participate to the clearance of pathogen-infected cells and tumour cells. NK cells and subsets of ILCs express the natural cytotoxicity receptors (NCRs) NKp46, NKp44 and NKp30 at their surface. NCRs have been shown to recognize a broad spectrum of ligands ranging from viral-, parasite- and bacterial-derived ligands to cellular ligands; however, the full identification of NCR ligands remains to be performed and will undoubtedly contribute to a better understanding of NK cell and ILC biology.
authors.affiliation: 1] Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Case 906, 13288 Marseille Cedex 9, France [2] INSERM, U1104, 13288 Marseille, France [3] CNRS, UMR7280, 13288 Marseille, France.
authors.forename: Philip H
authors.initials: PH
authors.lastname: Kruse
authors.affiliation: 1] Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Case 906, 13288 Marseille Cedex 9, France [2] INSERM, U1104, 13288 Marseille, France [3] CNRS, UMR7280, 13288 Marseille, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Matta
authors.affiliation: 1] Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Case 906, 13288 Marseille Cedex 9, France [2] INSERM, U1104, 13288 Marseille, France [3] CNRS, UMR7280, 13288 Marseille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ugolini
authors.affiliation: 1] Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Case 906, 13288 Marseille Cedex 9, France [2] INSERM, U1104, 13288 Marseille, France [3] CNRS, UMR7280, 13288 Marseille, France [4] Service d'Immunologie, Assistance Publique - Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D006801:Humans; D008024:Ligands; D018448:Models, Immunological; D010271:Parasites / Q000378:metabolism; D055636:Receptors, Natural Cytotoxicity Triggering / Q000378:metabolism*; D014780:Viruses / Q000378:metabolism
chemical_list: D008024:Ligands; D055636:Receptors, Natural Cytotoxicity Triggering