title: Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery.
abstract: Cell models based on human nasal epithelial stem/progenitor cells (hNESPCs) are developed to obtain functional ciliated cells on modified Transwell inserts. The live hNECs are integrated into microfluidic platforms to mimic the 3D features of the human upper airway for in vitro testing of gaseous formaldehyde toxicity via airway delivery.
authors.affiliation: Singapore Institute of Manufacturing Technology, 71 Nanyang Drive, Singapore. zpwang@SIMTech.a-star.edu.sg.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Chun Wei
authors.initials: CW
authors.lastname: Li
authors.forename: Huan Ming
authors.initials: HM
authors.lastname: Xia
authors.forename: Siew Shuen
authors.initials: SS
authors.lastname: Chao
authors.forename: De Yun
authors.initials: de Y
authors.lastname: Wang
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Wang
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002470:Cell Survival; D005557:Formaldehyde / Q000633:toxicity*; D006801:Humans; D051379:Mice; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D009297:Nasal Mucosa / Q000166:cytology* / Q000187:drug effects; D012137:Respiratory System; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D005557:Formaldehyde