title: Cerebral maturation on amplitude-integrated electroencephalography and perinatal exposures in preterm infants.
abstract: OBJECTIVE
  To determine the associations between perinatal exposures, cerebral maturation on amplitude-integrated encephalography (aEEG) and outcome.
  
  
  METHODS
  During this prospective cohort study, 136 infants ≤30 weeks estimated gestational age received 4 h of aEEG at four time points (between the first 2 weeks of life and term-equivalent age) during hospitalisation. Perinatal factors were documented. Associations between perinatal exposures and Burdjalov-scores were investigated. Neurodevelopmental outcome was assessed at the age of two.
  
  
  RESULTS
  Immature cyclicity on the initial aEEG recording was associated with higher CRIB score (p = 0.01), vaginal delivery (p = 0.02), male gender (p < 0.01) and death (p = 0.01). Perinatal factors associated with lower Burdjalov-scores included cerebral injury (p < 0.01), sepsis (p < 0.01), lower caffeine dose (p = 0.006), prolonged mechanical ventilation (p = 0.002) and death (p < 0.01). Burdjalov-scores at 30 (β = 2.62, p < 0.01) and 34 weeks postmenstrual age (β = 2.89, p = 0.05) predicted motor scores.
  
  
  CONCLUSIONS
  aEEG measures of cyclicity and Burdjalov-scores in the first 6 weeks of life, with an emphasis on 30 and 34 weeks postmenstrual age, demonstrated associations with perinatal factors known to predict adverse neurodevelopmental outcome.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Reynolds
authors.forename: Roberta G
authors.initials: RG
authors.lastname: Pineda
authors.forename: Amit
authors.initials: A
authors.lastname: Mathur
authors.forename: Claudine
authors.initials: C
authors.lastname: Vavasseur
authors.forename: Divyen K
authors.initials: DK
authors.lastname: Shah
authors.forename: Steve
authors.initials: S
authors.lastname: Liao
authors.forename: Terrie
authors.initials: T
authors.lastname: Inder
mesh_terms: D001720:Birth Injuries / Q000175:diagnosis*; D001930:Brain Injuries / Q000175:diagnosis*; D054022:Cerebrum / Q000254:growth & development*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D011446:Prospective Studies
keywords: Amplitude-integrated electroencephalography; Cerebral maturation; Neonatal intensive care; Perinatal exposure; Preterm infant