title: Impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography staging in newly diagnosed classical Hodgkin lymphoma: fewer cases with stage I disease and more with skeletal involvement.
abstract: (18)F-Fluorodeoxyglucose positron emission tomography/ computed tomography (PET/CT) is a highly accurate staging method in classical Hodgkin lymphoma (cHL). We retrospectively compared the staging results obtained in two large cohorts of patients with cHL diagnosed before (n = 324) and after (n = 406) the introduction of PET/CT staging in a retrospective study. In PET/CT staged patients, stage I disease was less frequent (16% vs. 27%, p < 0.001) while stage IV disease was more frequent (17% vs. 10%, p = 0.02). Imaging-detected skeletal involvement was recognized more often in PET/CT staged patients (17% vs. 2%, p < 0.001), and the presence of focal skeletal PET/CT lesions was associated with higher risk of progression (hazard ratio [HR] 1.96, 95% confidence interval [CI]: 1.14-3.36). The German Hodgkin Study Group (GHSG) risk classification (early, intermediate, advanced disease) predicted outcome in PET/CT staged patients. In conclusion, PET/CT led to higher disease stages, and the more frequently diagnosed skeletal lesions may be an adverse prognostic factor.
authors.affiliation: Department of Hematology, Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Tarec Christoffer
authors.initials: TC
authors.lastname: El-Galaly
authors.forename: Martin
authors.initials: M
authors.lastname: Hutchings
authors.forename: Karen Juul
authors.initials: KJ
authors.lastname: Mylam
authors.forename: Peter de Nully
authors.initials: Pde N
authors.lastname: Brown
authors.forename: Anne
authors.initials: A
authors.lastname: Bukh
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Johnsen
authors.forename: Peter
authors.initials: P
authors.lastname: Kamper
authors.forename: Annika
authors.initials: A
authors.lastname: Loft
authors.forename: Victor
authors.initials: V
authors.lastname: Iyer
authors.forename: Lars Christian
authors.initials: LC
authors.lastname: Gormsen
authors.forename: Anne Lerberg
authors.initials: AL
authors.lastname: Nielsen
authors.forename: Martin
authors.initials: M
authors.lastname: Bøgsted
authors.forename: Francesco
authors.initials: F
authors.lastname: d'Amore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D049268:Positron-Emission Tomography; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Hodgkin lymphoma; PET/CT; skeletal disease; staging