title: An oligofluorene truxene based distributed feedback laser for biosensing applications.
abstract: The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein-small molecule interaction is reported. The protein avidin was detected down to 1 μg mL(-1) using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to 50,000 μg mL(-1). Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable.
authors.affiliation: Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: annemarie.haughey@strath.ac.uk.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Haughey
authors.affiliation: Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: benoit.guilhabert@strath.ac.uk.
authors.forename: Benoit
authors.initials: B
authors.lastname: Guilhabert
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: alexander.kanibolotsky@strath.ac.uk.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Kanibolotsky
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: peter.skabara@strath.ac.uk.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Skabara
authors.affiliation: Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: m.dawson@strath.ac.uk.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Dawson
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: glenn.burley@strath.ac.uk.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Burley
authors.affiliation: Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: nicolas.laurand@strath.ac.uk.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Laurand
mesh_terms: D000818:Animals; D001360:Avidin / Q000032:analysis* / Q000378:metabolism*; D015374:Biosensing Techniques / Q000295:instrumentation*; D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism*; D019921:Biotinylation; D002417:Cattle; D004867:Equipment Design; D005449:Fluorenes / Q000737:chemistry*; D007834:Lasers; D012666:Semiconductors; D012680:Sensitivity and Specificity; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D005449:Fluorenes; D001360:Avidin; D012710:Serum Albumin, Bovine; D001710:Biotin; C004749:desthiobiotin
keywords: Biosensor; Laser; Oligofluorene truxene; Organic