title: Phase and size separations occurring during the injection of model pastes composed of β-tricalcium phosphate powder, glass beads and aqueous solutions.
abstract: Glass beads a few hundred micrometers in size were added to aqueous β-tricalcium phosphate pastes to simulate the effect of porogens and drug-loaded microspheres on the injectability of calcium phosphate cements and putties. The composition of the pastes was monitored during the injection process to assess the effect of glass bead content, glass bead size and paste composition on the paste injectability. The results revealed that the injection process led to both liquid and glass bead segregations: the liquid flowed faster than the glass beads, which themselves flowed faster than the β-tricalcium phosphate microparticles. In fact, even the particle size distribution of the glass beads was modified during injection. These results reveal that a good design of multiphasic injectable pastes is essential to prevent phase separation.
authors.affiliation: RMS Foundation, Bischmattstrasse 12, 2544 Bettlach, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Tadier
authors.affiliation: RMS Foundation, Bischmattstrasse 12, 2544 Bettlach, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Galea
authors.affiliation: RMS Foundation, Bischmattstrasse 12, 2544 Bettlach, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Charbonnier
authors.affiliation: Laboratoire de Biomécanique, Département de Génie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Baroud
authors.affiliation: RMS Foundation, Bischmattstrasse 12, 2544 Bettlach, Switzerland. Electronic address: marc.bohner@rms-foundation.ch.
authors.forename: M
authors.initials: M
authors.lastname: Bohner
mesh_terms: D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry; D007267:Injections; D008863:Microspheres; D010316:Particle Size; D011208:Powders; D012996:Solutions
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D011208:Powders; D012996:Solutions; C485817:beta-tricalcium phosphate; D006820:Hyaluronic Acid
keywords: Calcium phosphate cement; Filter-pressing; Injectability; Liquid phase migration; Size separation