title: Nd3+ sensitized up/down converting dual-mode nanomaterials for efficient in-vitro and in-vivo bioimaging excited at 800 nm.
abstract: Core/shell1/shell2/shell3 structured NaGdF4:Nd/NaYF4/NaGdF4:Nd,Yb,Er/NaYF4 nanocrystals were well designed and synthesized, each of the parts assume respective role and work together to achieve dual-mode upconverting (UC) and downconverting (DC) luminescence upon the low heat effect 800-nm excitation. Nd(3+), Yb(3+), Er(3+) tri-doped NaGdF4:Nd,Yb,Er UC layer [NIR (800 nm)-to-Visible (540 nm)] with a constitutional efficient 800 nm excitable property were achieved for the in-vitro bioimaging with low auto-fluorescence and photo-damage effects. Moreover, typical NIR (800 nm)-to-NIR (860-895 nm) DC luminescence of Nd(3+) has also been realized with this designed nanostructure. Due to the low heat effect, high penetration depth of the excitation and the high efficiency of the DC luminescence, the in-vivo high contrast DC imaging of a whole body nude mouse was achieved. We believe that such dual-mode luminescence NCs will open the door to engineering the excitation and emission wavelengths of NCs and will provide a new tool for a wide variety of applications in the fields of bioanalysis and biomedical.
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Dengke
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Chi
authors.initials: C
authors.lastname: Yao
authors.affiliation: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002712:Chlorides / Q000737:chemistry; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D004871:Erbium / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009354:Neodymium / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D013932:Thulium / Q000737:chemistry; D015018:Ytterbium / Q000737:chemistry
chemical_list: D002712:Chlorides; D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; C053952:erbium chloride; D009354:Neodymium; C042185:thulium chloride; D004871:Erbium; D013932:Thulium; D012964:Sodium; D005682:Gadolinium; C044841:ytterbium trichloride; D015018:Ytterbium; C038958:gadolinium chloride