title: [Research progress on B lymphocyte-induced maturation protein 1 and its relationship with the development of lymphoma].
abstract: Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 (Blimp 1) is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1's protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
authors.affiliation: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Zhi-Yin
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. E-mail: lijunmin@medmail.com.cn.
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Li
mesh_terms: D053301:B-Cell Maturation Antigen / Q000235:genetics; D001402:B-Lymphocytes; D002454:Cell Differentiation; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D053301:B-Cell Maturation Antigen; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1