title: Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections.
abstract: To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.
authors.affiliation: Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Steve P
authors.initials: SP
authors.lastname: Bernier
authors.affiliation: Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Workentine
authors.affiliation: Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Surette
mesh_terms: D019117:Burkholderia / Q000235:genetics*; D019121:Burkholderia Infections / Q000382:microbiology*; D003550:Cystic Fibrosis / Q000382:microbiology*; D014644:Genetic Variation; D006801:Humans; D008297:Male