title: Factor VIII inhibitor epitopes and an enigma.
abstract: In this issue of Blood, Walter et al provide an x-ray crystallographic structure of the factor VIII C2 domain in complex with 2 antibodies that illuminates how inhibitory antibodies complicate hemophilia A therapy.
authors.affiliation: VA BOSTON HEALTHCARE SYSTEM;
authors.forename: Gary E
authors.initials: GE
authors.lastname: Gilbert
mesh_terms: D000906:Antibodies / Q000737:chemistry*; D000939:Epitopes / Q000737:chemistry*; D005169:Factor VIII / Q000737:chemistry*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D050801:Ternary Complex Factors / Q000737:chemistry*
chemical_list: D000906:Antibodies; D000939:Epitopes; D050801:Ternary Complex Factors; D005169:Factor VIII