title: Antimicrobial and antioxidant activities and effect of 1-hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus Berkleasmium sp. Dzf12.
abstract: Two spirobisnaphthalenes, namely palmarumycins C2 and C3, were isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. After addition of 1-hexadecene at 10% to the medium on day 6 of culture, the maximal yields of palmarumycins C2 and C3 were obtained as 0.40 g/L and 1.19 g/L, which were 40.00 fold and 59.50 fold higher, respectively, in comparison with those of the control (0.01 g/L and 0.02 g/L). The results indicated that addition of 1-hexadecene can be an effective strategy for enhancing the production of palmarumycins C2 and C3 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Palmarumycin C3 exhibited stronger antimicrobial and antioxidant activities than palmarumycin C2.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mou
authors.forename: Jiajia
authors.initials: J
authors.lastname: Meng
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Fu
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Mingan
authors.initials: M
authors.lastname: Wang
authors.forename: Youliang
authors.initials: Y
authors.lastname: Peng
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. lgzhou@cau.edu.cn.
authors.forename: Ligang
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D060026:Endophytes / Q000187:drug effects* / Q000378:metabolism; D005233:Fatty Alcohols / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D005233:Fatty Alcohols; D009281:Naphthalenes; D013141:Spiro Compounds; C462879:palmarumycin C2; C005031:cetyl alcohol