title: Myeloma-related kidney disease.
abstract: Multiple myeloma is a malignant plasma cell disorder characterized by the overproduction of monoclonal proteins. The kidney is 1 of the major target organs of multiple myeloma. Most often, this is the result of the monoclonal proteins, which can injure the kidney via several mechanisms. In some cases, direct invasion by myeloma cells and/or bone marrow cells can also result in kidney injury. A kidney biopsy can help distinguish the various myeloma-related kidney diseases and aid in the treatment plan.
authors.affiliation: Division of Nephrology and Hypertension, and Hematology, Mayo Clinic, Rochester, MN; and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address: leung.nelson@mayo.edu.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.affiliation: Division of Nephrology and Hypertension, and Hematology, Mayo Clinic, Rochester, MN; and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors.forename: Samih H
authors.initials: SH
authors.lastname: Nasr
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications / Q000378:metabolism; D005198:Fanconi Syndrome / Q000150:complications / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000378:metabolism; D006801:Humans; D007147:Immunoglobulin Light Chains; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D009101:Multiple Myeloma / Q000150:complications* / Q000378:metabolism
chemical_list: D007147:Immunoglobulin Light Chains
keywords: Amyloidosis; Cast nephropathy; Kidney; MIDD; Multiple myeloma