title: Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells.
abstract: Survivin-3B (S-3B), an alternative splice isoform of survivin, plays a key role in tumorigenesis. S-3B promotes the escape of malignant cells from immune recognition by blocking the cytotoxicity of natural killer (NK) cells. Such an effect reflects the ability of S-3B to interfere with the assembly of the so-called "death-inducing signaling complex" upon the interaction of FAS with its ligand (FASL). S-3B also inhibits the activation of caspase-6, thus increasing the resistance of neoplastic cells to granzyme B and various chemotherapeutics.
authors.affiliation: INSERM U866; Department of Tumor Biology and Pathology; Unit of Molecular Biology; Dijon, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Végran
authors.affiliation: Centre Georges-François Leclerc; Department of Tumor Biology and Pathology; Unit of Molecular Biology; Dijon, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Boidot
keywords: caspase-6; caspase-8; survivin-3B; treatment response; tumor escape; tumorigenesis