title: Trends in antimicrobial non-susceptibility in methicillin-resistant Staphylococcus aureus from Germany (2004-2011).
abstract: We analysed trends in antimicrobial non-susceptibility in methicillin-resistant Staphylococcus aureus (MSRA) from Germany to assess the impact of the changing population structure of MRSA on antimicrobial resistance rates. During two large nationwide multicentre studies in 2004-2005 and 2010-2011, we collected consecutively spa-genotyped MRSA isolates. The increase in non-susceptibility rates for tetracycline and trimethoprim-sulphamethoxazole was associated with the spread of livestock-associated MRSA. A decrease in non-susceptibility rates for aminoglycosides and quinolones affected all major lineages (spa-clonal complexes 003, 008, and 032). All isolated remained susceptible to glycopeptides and linezolid.
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schaumburg
authors.forename: E A
authors.initials: EA
authors.lastname: Idelevich
authors.forename: G
authors.initials: G
authors.lastname: Peters
authors.forename: A
authors.initials: A
authors.lastname: Mellmann
authors.forename: C
authors.initials: C
authors.lastname: von Eiff
authors.forename: K
authors.initials: K
authors.lastname: Becker
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Genotype; Germany; LA-MRSA; methicillin-resistant Staphylococcus aureus; resistance