title: Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
abstract: Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model. After the i.pl. injection of CFA, mechanical allodynia (decrease of mechanical threshold) was observed in ipsilateral paw. The antinociceptive effect of fentanyl and oxycodone injected s.c. against mechanical allodynia in inflammatory pain state was reduced bilaterally at 1 day after CFA pretreatment. However, the antinociceptive effect of methadone injected s.c. against mechanical allodynia in inflammatory pain state was reduced unilaterally at 1 day after CFA pretreatment. Moreover, the reduction of the antinociceptive effect of methadone in ipsilateral paw on inflammatory pain state was smaller than those of fentanyl or oxycodone. In conclusion, the alternation of the antinociceptive effect of narcotic analgesics in inflammatory pain state is variable among the narcotic analgesics used.
authors.affiliation: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Mizoguchi
authors.affiliation: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Chizuko
authors.initials: C
authors.lastname: Watanabe
authors.affiliation: First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sakurada
authors.affiliation: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address: s-sakura@tohoku-pharm.ac.jp.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sakurada
mesh_terms: D000818:Animals; D005283:Fentanyl / Q000627:therapeutic use; D005620:Freund's Adjuvant; D006930:Hyperalgesia / Q000188:drug therapy / Q000503:physiopathology; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D051379:Mice; D009294:Narcotics / Q000627:therapeutic use*; D010098:Oxycodone / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D017288:Pain Threshold / Q000187:drug effects; D010812:Physical Stimulation; D014110:Touch
chemical_list: D009294:Narcotics; D005620:Freund's Adjuvant; D010098:Oxycodone; D008691:Methadone; D005283:Fentanyl
keywords: Antinociception; Inflammatory pain; Mice; Narcotic analgesic; μ-Receptor