title: New developments in gold-catalyzed manipulation of inactivated alkenes.
abstract: Over the recent years, the nucleophilic manipulation of inactivated carbon-carbon double bonds has gained remarkable credit in the chemical community. As a matter of fact, despite lower reactivity with respect to alkynyl and allenyl counterparts, chemical functionalization of isolated alkenes, via carbon- as well as hetero atom-based nucleophiles, would provide direct access to theoretically unlimited added value of molecular motifs. In this context, homogenous [Au(I)] and [Au(III)] catalysis continues to inspire developments within organic synthesis, providing reliable responses to this interrogative, by combining crucial aspects such as chemical selectivity/efficiency with mild reaction parameters. This review intends to summarize the recent progresses in the field, with particular emphasis on mechanistic details.
authors.affiliation: Department of Chemistry "G. Ciamician", Alma Mater Studiorum - University of Bologna, via Selmi 2, 40126 Bologna, Italy.
authors.forename: Michel
authors.initials: M
authors.lastname: Chiarucci
authors.affiliation: Department of Chemistry "G. Ciamician", Alma Mater Studiorum - University of Bologna, via Selmi 2, 40126 Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
keywords: alkene; gold catalysis; mechanism; organic synthesis