title: Metal-free direct intramolecular carbotrifluoromethylation of alkenes to functionalized trifluoromethyl azaheterocycles.
abstract: The first example of a metal-free direct carbotrifluoromethylation of alkenes using inexpensive TMSCF3 as the CF3 source is described. The methodology not only exhibits high chemoselectivity for this transformation but also expands the substrate scope that is difficult to access by known transition-metal-catalyzed methods.
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.forename: Sheng-Cai
authors.initials: SC
authors.lastname: Zheng
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Xiong
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D005617:Chlorofluorocarbons, Methane; D006845:Hydrocarbons, Fluorinated; D012821:Silanes; C509472:trimethyl(trifluoromethyl)silane; C009554:fluoroform