title: Stereoselective titanium-mediated aldol reactions of a chiral lactate-derived ethyl ketone with ketones.
abstract: Aldol reactions of titanium enolates of lactate-derived ethyl ketone 1 with other ketones proceed in a very efficient and stereocontrolled manner provided that a further equivalent of TiCl4 is added to the reacting mixture. The scope of these reactions encompasses simple ketones such as acetone or cyclohexanone as well as other ketones that contain potential chelating groups such as pyruvate esters or α- and β-hydroxy ketones.
authors.affiliation: Departament de Química Orgànica and ‡Departament de Cristal·lografia, Mineralogia i Dipòsits Minerals, Universitat de Barcelona , 08028 Barcelona, Catalonia, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Alcoberro
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gómez-Palomino
authors.forename: Ricard
authors.initials: R
authors.lastname: Solà
authors.forename: Pedro
authors.initials: P
authors.lastname: Romea
authors.forename: Fèlix
authors.initials: F
authors.lastname: Urpí
authors.forename: Mercè
authors.initials: M
authors.lastname: Font-Bardia