title: A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.
abstract: Highlight describes the recently discovered prodrug activation mechanism found in the biosynthesis of nonribosomally produced peptides and peptide/polyketide hybrids as well as related mechanisms.
authors.affiliation: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, Biozentrum/Campus Riedberg, 60438 Frankfurt am Main, Germany. h.bode@bio.uni-frankfurt.de.
authors.forename: Daniela
authors.initials: D
authors.lastname: Reimer
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology*; D015394:Molecular Structure; D010452:Peptide Biosynthesis; D010453:Peptide Synthases / Q000378:metabolism*; D048630:Polyketide Synthases / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D011355:Prodrugs; D048630:Polyketide Synthases; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase