title: A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?
abstract: An analysis to inventory all immune epitope data related to multiple sclerosis (MS) was performed using the Immune Epitope Database (IEDB). The analysis revealed that MS related data represent >20% of all autoimmune data, and that studies of EAE predominate; only 22% of the references describe human data. To date, >5800 unique peptides, analogs, mimotopes, and/or non-protein epitopes have been reported from 861 references, including data describing myelin-containing, as well as non-myelin antigens. This work provides a reference point for the scientific community of the universe of available data for MS-related adaptive immunity in the context of EAE and human disease.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA. Electronic address: Kvaughan@liai.org.
authors.forename: Kerrie
authors.initials: K
authors.lastname: Vaughan
authors.affiliation: La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
authors.affiliation: Department of Neurology, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA; Human and Translational Immunology Program, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: O'Connor
authors.affiliation: Neuroimmunology and MS Research, Department of Neurology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Roland
authors.initials: R
authors.lastname: Martin
authors.affiliation: La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D030562:Databases, Protein; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D018604:Epitope Mapping; D000939:Epitopes / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology
chemical_list: D016207:Cytokines; D000939:Epitopes; D018992:Myelin-Associated Glycoprotein
keywords: Antibody; Epitope; Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis; T cell