title: Phytochemical and pharmacological studies on Radix Angelica sinensis.
abstract: The roots of Angelica sinensis (RAS), are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women's diseases. It has also been widely marketed as health food for women's care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregulatory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China; Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300410, China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: Chen
authors.affiliation: Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300410, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Xiao
authors.affiliation: Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300410, China.
authors.forename: Lan-Lan
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. Electronic address: liuchangxiao@163.com.
authors.forename: Chang-Xiao
authors.initials: CX
authors.lastname: Liu
mesh_terms: D029971:Angelica sinensis / Q000009:adverse effects / Q000737:chemistry*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; C044613:angelicae sinensis extract
keywords: Chemical constituents; Clinical applications; Interactions; Pharmacological effect; Radix Angelica Sinensis; Toxicity