title: Acute kidney injury in the cancer patient.
abstract: Acute kidney injury (AKI) is a frequent and significant complication of cancer and cancer therapy. Cancer patients frequently encounter risk factors for AKI including older age, CKD, prerenal conditions, sepsis, exposure to nephrotoxins, and obstructive physiology. AKI can also be secondary to paraneoplastic conditions, including glomerulonephritis and microangiopathic processes. This complication can have significant consequences, including effects on patients' ability to continue to receive therapy for their malignancy. This review will serve to summarize potential etiologies of AKI that present in patients with cancer as well as to highlight specific patient populations, such as the critically ill cancer patient.
authors.affiliation: Department of Medicine and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, VA. Electronic address: gac6s@virginia.edu.
authors.forename: G Adam
authors.initials: GA
authors.lastname: Campbell
authors.affiliation: Department of Medicine and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, VA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Medicine and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, VA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D007511:Ischemia / Q000150:complications; D007668:Kidney / Q000098:blood supply; D007683:Kidney Tubular Necrosis, Acute / Q000150:complications; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012307:Risk Factors; D018805:Sepsis / Q000150:complications; D015275:Tumor Lysis Syndrome / Q000150:complications*; D014517:Ureteral Obstruction / Q000150:complications; D001748:Urinary Bladder Neck Obstruction / Q000150:complications
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media
keywords: AKI; Acute renal failure; Malignancy; Nephrotoxins; Oncology