title: Correlates of non-adherence to antiretroviral therapy in a cohort of HIV-positive drug users receiving antiretroviral therapy in Hanoi, Vietnam.
abstract: The HIV epidemic in Vietnam is concentrated, with high prevalence estimates among injection drug users and commercial sex workers. Socio-demographics, substance use and clinical correlates of antiretroviral therapy non-adherence were studied in 100 HIV-1 infected drug users receiving antiretroviral therapy for at least 6 months in Hanoi, Vietnam. All study participants were men with a mean age of 29.9 ± 4.9 years. The median duration on antiretroviral therapy was 16.2 ± 12.7 months; 83% reported 'very good' or 'perfect' adherence in the past 30 days on a subjective one-item Likert scale at time of study enrollment; 48% of participants reported drug use within the previous 6 months, with 22% reporting current drug use. Injection drug use with or without non-injection drug use in the past 6 months (95% C.I. 2.19, 1.30-3.69) and years on antiretroviral therapy (95% C.I. 1.43, 1.14-1.78) were correlated with suboptimal adherence. These findings support Vietnam's ongoing scale-up of harm reduction programmes for injection drug users and their integration with antiretroviral therapy delivery. Moreover, results highlight the need to identify and implement new ways to support high levels of antiretroviral therapy adherence as duration on antiretroviral therapy increases.
authors.affiliation: Tufts Medical Center, Boston, USA.|Tufts University School of Medicine, Boston, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Jordan
authors.affiliation: Tufts Medical Center, Boston, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Obeng-Aduasare
authors.affiliation: Tufts Medical Center, Boston, USA.
authors.forename: H
authors.initials: H
authors.lastname: Sheehan
authors.affiliation: Tufts Medical Center, Boston, USA.|Tufts University School of Medicine, Boston, USA.
authors.forename: S Y
authors.initials: SY
authors.lastname: Hong
authors.affiliation: Tufts University School of Medicine, Boston, USA.
authors.forename: N
authors.initials: N
authors.lastname: Terrin
authors.affiliation: National Hospital of Tropical Diseases, Hanoi, Vietnam.
authors.forename: D V
authors.initials: DV
authors.lastname: Duong
authors.affiliation: National Hospital of Tropical Diseases, Hanoi, Vietnam.
authors.forename: N V
authors.initials: NV
authors.lastname: Trung
authors.affiliation: Tufts Medical Center, Boston, USA.|Tufts University School of Medicine, Boston, USA.
authors.forename: C
authors.initials: C
authors.lastname: Wanke
authors.affiliation: National Hospital of Tropical Diseases, Hanoi, Vietnam.
authors.forename: N V
authors.initials: NV
authors.lastname: Kinh
authors.affiliation: Tufts Medical Center, Boston, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Tang
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D055030:Drug Users / Q000706:statistics & numerical data*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D012959:Socioeconomic Factors; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000453:epidemiology; D016896:Treatment Outcome; D014744:Vietnam / Q000453:epidemiology; D019562:Viral Load; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents
keywords: AIDS; HIV; Vietnam; adherence; antiretroviral therapy; injection drug users; substance abuse