title: [Significance of pseudocapsule in the excision of pituitary adenomas in transsphenoidal surgery].
abstract: OBJECTIVE
  To explore the significance of pseudocapsule in the excision of pituitary adenomas in transsphenoidal surgery.
  
  
  METHODS
  For 22 patients with pituitary adenomas over a period of 2 years at Peking Union Medical College Hospital, resection of pseudocapsule was applied for complete tumor removal. Pituitary function test and radiological imaging were performed at pre-operation, 3 months post-operation and at subsequent 6-12 months intervals postoperatively.
  
  
  RESULTS
  All pituitary adenomas were totally removed under microscope. The symptoms of headache, disorder of sight and visual field disappeared postoperatively in nonfunctional pituitary adenomas. The GH levels of 2/5 growth hormone secreting adenoma patients were 4.2 and 7.7 µg/L while it was under 1 µg/L for another 3. The postoperative level of prolactin was 4.3 µg/L in prolactin secreting adenoma. The level of adrenocorticotropic hormone decreased under 5 ng/L except one was 15.7 ng/L. Leakage of cerebrospinal fluid occurred intraoperatively in 3 patients and postoperatively in 1. No leakage was found after repair. Diabetes insipidus occurred in one patient and was controlled with Minirin. Pseudocapsule was confirmed by pathological examination. Special staining revealed reticulum fibers in pseudocapsule.
  
  
  CONCLUSIONS
  Resection of pseudocapsule may achieve a higher remission rate without deteriorating pituitary function.
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Deng
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lian
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Gui-lin
authors.initials: GL
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Jun-ji
authors.initials: JJ
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Wan-chen
authors.initials: WC
authors.lastname: Dou
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Xin-jie
authors.initials: XJ
authors.lastname: Bao
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Dai
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Ding-rong
authors.initials: DR
authors.lastname: Zhong
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China. Email: wangrz@126.com.
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D013101:Sphenoid Sinus / Q000601:surgery*; D055815:Young Adult