title: A study of cytological changes in the bone marrow of patients with severe fever with thrombocytopenia syndrome.
abstract: BACKGROUND
  Peripheral blood leucopenia and thrombocytopenia are the main manifestations in severe fever with thrombocytopenia syndrome (SFTS) patients. However, the underlying causes are poorly understood. Therefore, we aimed to investigate cytology of bone marrow samples collected from SFTS patients.
  
  
  METHODS
  10 SFTS patients were identified by typical clinical manifestations, detection of peripheral blood leucopenia and thrombocytopenia, and nucleic acid-based detection of the newly identified bunyavirus. SFTS patients, along with 10 participants with acute aplastic anemia and 10 healthy volunteers were enrolled in this study after written informed consent to undergo bone marrow cytological examination.
  
  
  RESULTS
  We observed similar bone marrow properties in SFTS patients and healthy volunteers, significantly different from the characteristics observed in acute aplastic anemia patients.
  
  
  CONCLUSIONS
  Similarities between bone marrow samples collected from SFTS patients and healthy volunteers suggest that peripheral blood leucopenia and thrombocytopenia do not result from bone marrow cell plasticity.
authors.affiliation: Department of Infectious Diseases , Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Xing
authors.initials: X
authors.lastname: QuanTai
authors.affiliation: Department of Infectious Diseases , Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Chen
authors.initials: C
authors.lastname: FengZhe
authors.affiliation: Infectious Diseases Hospital of Jinan, Jinan, China.
authors.forename: Song
authors.initials: S
authors.lastname: XiuGuang
authors.affiliation: Department of Blood Laboratory, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Chen
authors.initials: C
authors.lastname: DongGe
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D005334:Fever; D006801:Humans; D007970:Leukopenia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013921:Thrombocytopenia / Q000473:pathology*