title: Diffusion-weighted imaging and demyelinating diseases: new aspects of an old advanced sequence.
abstract: OBJECTIVE
  The purpose of this article is to discuss classic applications in diffusion-weighted imaging (DWI) in demyelinating disease and progression of DWI in the near future.
  
  
  CONCLUSIONS
  DWI is an advanced technique used in the follow-up of demyelinating disease patients, focusing on the diagnosis of a new lesion before contrast enhancement. With technical advances, diffusion-tensor imaging; new postprocessing techniques, such as tract-based spatial statistics; new ways of calculating diffusion, such as kurtosis; and new applications for DWI and its spectrum are about to arise.
authors.affiliation: 1 All authors: Department of Radiology, Federal University of Rio de Janeiro, Clinica de Diagnostico por imagem-CDPI/DASA, Rua: Eneida de Morais, 141/203. Ilha do Governador, Rio de Janeiro, RJ, Brazil, CEP 21920-230.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Rueda-Lopes
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Hygino da Cruz
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Doring
authors.forename: Emerson L
authors.initials: EL
authors.lastname: Gasparetto
mesh_terms: D003287:Contrast Media; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018450:Disease Progression; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods
chemical_list: D003287:Contrast Media