title: Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: a community-based survey and hematologic features.
abstract: A community-based survey was conducted to determine the prevalence and gene frequency of Hemoglobin Constant Spring (Hb CS) and other forms of thalassemia among an ethnic minority in Vietnam. A total of 298 ethnic minority women, the Có-Tu, participated. Hematological parameters and hemoglobin profiles were analyzed using standard automated analyzers. Alpha- and beta-thalassemia mutations were identified using polymerase chain reaction (PCR) based technology. Of the 298 women, 141 (47.3%) carried thalassemia genes. Hemoglobin Constant Spring (Hb CS) is the most common with a markedly high frequency of 0.143 (overall prevalence=26.2%). The heterozygous state of Hb CS was found in one-fifth (20.5%) of women participating. Seven women (2.4%) were Hb CS homozygote. The overall prevalence for Hb E was 13.8%, and 10.7% for α(+)-thalassemia. Other forms of thalassemia included 0.67% β-thalassemia, and 0.34% Hb Paksé. None of the participants had the α(0)-thalassemia gene. The study provides basic epidemiological information about Hb CS as well as other forms of thalassemia for a specific group of an ethnic minority in Vietnam. The data will be useful for further study on the distribution of thalassemia in Southeast Asia.
authors.affiliation: Graduate School, Khon Kaen University, Thailand; Hue College of Medicine and Pharmacy, Hue, Viet Nam.
authors.forename: Van Hoa
authors.initials: VH
authors.lastname: Nguyen
authors.affiliation: Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand. Electronic address: kanokwan@kku.ac.th.
authors.forename: Kanokwan
authors.initials: K
authors.lastname: Sanchaisuriya
authors.affiliation: Graduate School, Khon Kaen University, Thailand; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand.
authors.forename: Kasama
authors.initials: K
authors.lastname: Wongprachum
authors.affiliation: Thua Thien Hue Province Health Service, Viet Nam.
authors.forename: Mau Duyen
authors.initials: MD
authors.lastname: Nguyen
authors.affiliation: Hematoglogy Service, Hue Central Hospital, Viet Nam.
authors.forename: Thi Thuy Hoa
authors.initials: TT
authors.lastname: Phan
authors.affiliation: Hue College of Medicine and Pharmacy, Hue, Viet Nam.
authors.forename: Van Thang
authors.initials: VT
authors.lastname: Vo
authors.affiliation: Faculty of Public Health, Khon Kaen University, Thailand.
authors.forename: Pattara
authors.initials: P
authors.lastname: Sanchaisuriya
authors.affiliation: Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand.
authors.forename: Supan
authors.initials: S
authors.lastname: Fucharoen
authors.affiliation: Faculty of Public Health, Khon Kaen University, Thailand.
authors.forename: Frank P
authors.initials: FP
authors.lastname: Schelp
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005843:Geography; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008913:Minority Groups; D015995:Prevalence; D013789:Thalassemia / Q000453:epidemiology / Q000235:genetics; D014744:Vietnam / Q000453:epidemiology
chemical_list: D006455:Hemoglobins, Abnormal; C035541:Hemoglobin Constant Spring
keywords: Ethnic minority; Hemoglobin Constant Spring; Hemoglobinopathies; Thalassemia; Vietnam