title: Obesity and cardiovascular dysfunction: A role for resveratrol?
abstract: Obesity, characterized by excess adipose tissue is now becoming a worldwide epidemic. Various studies have suggested that obesity per se is an independent cardiovascular risk factor, as well as predisposing to type 2 diabetes, hypertension and dyslipidaemia. Furthermore, obesity induces insulin resistance, which is associated with development of cardiovascular diseases that include hypertension, and reduced endothelial function. A variety of pharmacological and physiological as well as surgical interventions have been used to counteract deleterious effects of obesity with some degree of success. A number of new medicinal agents are being considered as a candidate for managing obesity and its associated cardiovascular abnormalities. Resveratrol, a naturally occurring phenolic trihydroxystilbene substance, which is present in a variety of plants have been shown to reverse detrimental effects of diet-induced obesity. This review examines role of resveratrol as a future anti-obesity agent.:
authors.affiliation: Obesity Biology Unit, School of Clinical Science, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK. Electronic address:naderali@liv.ac.uk.
authors.forename: Ebrahim K
authors.initials: EK
authors.lastname: Naderali