title: Iron status and C-reactive protein in canine leishmaniasis.
abstract: OBJECTIVE
  To investigate the iron status, its relationship with C-reactive protein and the prognostic value of both in canine leishmaniasis.
  
  
  METHODS
  Eighty-six dogs with leishmaniasis and two control groups (healthy dogs and dogs with diseases other than leishmaniasis) were selected. Iron status indicators and C-reactive protein were compared between the three groups. Correlations between C-reactive protein and iron, ferritin and total iron-binding capacity were evaluated in dogs with leishmaniasis. Iron, total iron-binding capacity and ferritin were compared between dogs stratified according to similar C-reactive protein concentrations. The mortality rate at 30 days post-diagnosis was compared between groups. Iron status indicators and C-reactive protein were compared between survivors and non-survivors.
  
  
  RESULTS
  Dogs with leishmaniasis had lower iron and total iron-binding capacity and higher ferritin and C-reactive protein. There was a significant but low correlation of C-reactive protein with iron, ferritin and total iron-binding capacity. Dogs with leishmaniasis had decreased iron and total iron-binding capacity and increased ferritin compared to other ill patients with similar C-reactive protein concentrations. Mortality was not significantly different between groups but non-survivor dogs with leishmaniasis had higher C-reactive protein and lower total iron-binding capacity.
  
  
  CONCLUSIONS
  Inflammation contributes to the iron status alterations found in canine leishmaniasis but other mechanisms are likely involved. Low total iron-binding capacity and increased C-reactive protein are risk factors for outcome in canine leishmaniasis.
authors.affiliation: Clinica Veterinaria San Marco, Padua, Italy.|Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Silvestrini
authors.affiliation: Clinica Veterinaria San Marco, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zoia
authors.affiliation: Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Planellas
authors.affiliation: Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Roura
authors.affiliation: Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pastor
authors.affiliation: Departamento de Medicina y Cirugía Animal, Universidad de Murcia, Murcia, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cerón
authors.affiliation: Clinica Veterinaria San Marco, Padua, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Caldin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000469:parasitology*; D004285:Dogs; D005260:Female; D005293:Ferritins / Q000097:blood; D007501:Iron / Q000097:blood*; D007896:Leishmaniasis / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000662:veterinary*; D008297:Male; D011379:Prognosis
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron