title: Long range linkage disequilibrium across the human genome.
abstract: Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the disequilibrium between all pairs of SNPs on each chromosome (a total of >2×10(11) values) and evaluated significance of overall disequilibrium using randomization. The results show an excess of associations between pairs of distant sites (separated by >0.25 cM) on all of the 22 autosomes. We discuss possible explanations for this observation.
authors.affiliation: Department of Integrative Biology, University of Texas, Austin, Texas, United States of America.
authors.forename: Evan
authors.initials: E
authors.lastname: Koch
authors.affiliation: Department of Integrative Biology, University of Texas, Austin, Texas, United States of America.
authors.forename: Mickey
authors.initials: M
authors.lastname: Ristroph
authors.affiliation: Department of Integrative Biology, University of Texas, Austin, Texas, United States of America.
authors.forename: Mark
authors.initials: M
authors.lastname: Kirkpatrick
mesh_terms: D015894:Genome, Human / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics