title: Spiny keratoderma.
abstract: We present a case of a 48-year-old man with an approximately 30-year history of spiny projections on the palms, which were histopathologically consistent with spiny keratoderma. Spiny keratoderma is a rare entity of unknown etiology that has been described with both hereditary and acquired variants. The hereditary form, which is most likely the diagnosis in our patient, manifests at a younger age and is benign. The acquired variant, which presents in older adults, has been associated with a variety of systemic diseases and malignant conditions. In patients suspected of having acquired spiny keratoderma, an evaluation for malignant conditions may be warranted.
authors.affiliation: New York University School of Medicine.
authors.forename: Arielle
authors.initials: A
authors.lastname: Nagler
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Boyd
authors.forename: Rishi R
authors.initials: RR
authors.lastname: Patel
authors.forename: Hyun-soo
authors.initials: HS
authors.lastname: Lee
mesh_terms: D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D008297:Male; D008875:Middle Aged