title: SPECT radiopharmaceuticals for dementia.
abstract: Over the last decade the interest towards functional neuroimaging has gradually increased, especially in the field of neurodegenerative diseases. At present, diagnosis of dementia is mostly clinical. Numerous modalities of neuroimaging are today available, each of them allowing a different aspect of neurodegeneration to be investigated. Although during the last period many have predicted a forthcoming disappearance of SPECT imaging in favour of the PET imaging, many new radiotracers SPECT, dual-SPECT tracers techniques and receptor targeting designed radiopharmaceuticals are currently at study. Besides, last decade has also assisted to the development of new SPECT imaging systems, most of them integrated with other imaging modalities (MRI, CT, ultrasound techniques), granting improved imaging capabilities. All these improved conditions, especially appealing for the neuroimaging, together with the new radiopharmaceuticals in development may renovate the interest for SPECT clinical applications.
authors.forename: Claudio
authors.initials: C
authors.lastname: Guidotti
authors.forename: Daniela
authors.initials: D
authors.lastname: Farioli
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Gaeta
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Giovannini
authors.forename: Patrizia
authors.initials: P
authors.lastname: Lazzeri
authors.forename: Martina
authors.initials: M
authors.lastname: Meniconi
authors.affiliation: Nuclear Medicine Department, S. Andrea Hospital via Vittorio Veneto, 197, La Spezia, Italy. guidotti.claudio@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciarmiello
mesh_terms: D003545:Cysteine / Q000031:analogs & derivatives*; D003704:Dementia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D059907:Functional Neuroimaging / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D017410:Practice Guidelines as Topic; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; C059659:technetium Tc 99m bicisate; D003545:Cysteine