title: Extensive psoriasis induced by pegylated interferon alfa-2a and ribavirin in the treatment of chronic hepatitis C.
abstract: A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened dramatically during therapy. Because of the extensive skin eruptions, he stopped therapy for chronic hepatitis C and subsequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate ointment. After this, the psoriasis improved in a slow but comprehensive manner. Our case suggests that physicians should keep in mind the possibility of psoriasis as a side effect of interferon treatment for chronic hepatitis C.
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Gun-Wook
authors.initials: GW
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Seung-Wook
authors.initials: SW
authors.lastname: Jwa
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Margaret
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Hoon-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-medical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-medical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Moon-Bum
authors.initials: MB
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Hyun-Chang
authors.initials: HC
authors.lastname: Ko
keywords: Hepatitis C; Peginterferon alfa-2a; Psoriasis; Ribavirin