title: Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyindole analogs through environment friendly reaction.
abstract: BACKGROUND
  The development of newer synthetic approaches toward the synthesis of polynuclear heteroaromatics and their application in the synthesis of some biologically active compounds has been discussed in this study.
  
  
  METHODS
  The synthesis of novel spiro pyrrolidino oxindoles was performed for the construction of amino acid linked polynuclear heteroaromatics by cycloaddition reaction. This reaction method is one of the most important methods for the construction of spiro pyrrolidino oxindole from the commercially available starting material isatin. Then the synthesized compounds were subjected for evaluation of nitric oxide scavenging and cytotoxic effects against tumor cell lines.
  
  
  RESULTS
  All the six synthesized compounds demonstrated promising antioxidant and cytotoxic effects in vitro.
  
  
  CONCLUSIONS
  Form the present study, it can be concluded that the synthesized compounds are fruitful in terms of their chemical purity, structural novelty, marked biological activities (antioxidant and cytotoxic) in vitro and last of all the lucid and picturesque synthetic methodology to synthesize the molecules in a in a non-hazardous and environmental friendly way.
authors.affiliation: Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly, West Bengal, India.
authors.forename: Sanjit Kumar
authors.initials: SK
authors.lastname: Das
authors.affiliation: Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly, West Bengal, India.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Kundu
keywords: Cycloaddition reaction; MTT assay; isatin; spiro pyrrolidino oxindole