title: A questionnaire-based study in Calabria on the knowledge of off-label drugs in pediatrics.
abstract: Off-label use is very common among pediatricians, and the main cause is attributable to the lack of drugs specifically designed and marketed for children in different age groups. In this study, we evaluated, through a questionnaire, the knowledge of off-label drugs in pediatrics. Furthermore, we made a directory of 28 off-label drugs most commonly used by pediatricians in agreement with data obtained from Italian Agency for drugs (AIFA) referred to the law no. 648/1996; 180 pediatricians referred to the Italian Society of Pediatrics Calabrian section were asked to complete an online anonymous questionnaire. Eighty five (47.3%) of these completed the anonymous questionnaire, 40% revealed that they used off-label drugs "sometimes"; generally, drugs were used off-label for age and to treat respiratory diseases. For 75 pediatricians (88%) the information about the risk/benefit of off-label drugs is inadequate and 63 pediatricians (74%) did not have a good knowledge about this practice. In conclusion, the knowledge of off-label drugs is very low in pediatricians; more information about off-label drugs could be useful in order to improve the appropriateness of drugs' prescription and to reduce the development of side effects and improving drug safety.
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Saullo
authors.affiliation: Unità Operativa di Pediatria, Presidio Ospedaliero "Giovanni Paolo II" Lamezia Terme, Azienda Sanitaria di Catanzaro, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Saullo
authors.affiliation: Unità Operativa di Pediatria, Presidio Ospedaliero "Giovanni Paolo II" Lamezia Terme, Azienda Sanitaria di Catanzaro, Italy.
authors.forename: Mimma
authors.initials: M
authors.lastname: Caloiero
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Menniti
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carbone
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Serafina
authors.initials: S
authors.lastname: Chimirri
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Paletta
authors.affiliation: Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
keywords: Children; off-label drugs; pediatrics; questionnaire