title: Translational genomics in cancer research: converting profiles into personalized cancer medicine.
abstract: Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
authors.forename: Lalit
authors.initials: L
authors.lastname: Patel
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Parker
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;
authors.forename: Da
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
keywords: Cancer; genomics; personalized medicine; translation