title: Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years.
abstract: The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 8540 patients with HNC and 9844 controls from 19 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. A meta-analysis was done on the studies that applied fixed and random models. People have an increase of polymorphism expression related to inflammation (NFKB1-294-ATTG, TNFα308-A2A2/A2A1, and TNFβ252- B2B2/B2B1) or carcinogenic metabolism (GSTM1 null, and CYP1A1 m1/m1), representative of malignancy development. Furthermore, the increased expression of genes associated with the stabilization and repair of the cellular (OGG1-Asp267Asn, Ser279Gly Ile253Phe, 1578A>T, 1582C>T Ala399Glu (1542C>A) 1582insG 1543_1544delCT), and genes associated with the regulation of proliferation, apoptosis or tumor survival (miRNA499-CT/CC, CRYABC802G-CG/GG) are considered as risk factors. In this scheme, only the polymorphisms of ADH7A92G-GG and DEC1606-T/C genes are protective against malignancy transformation. The TP53, GSTM1 and CYPA1genes have been evaluated in more than one study and analyzed for homogeneity in each genotype. The meta-analysis showed no significant association between different allelic variants of Arg72Pro rs1042522 and SCCHN risk. In a model of tumorigenesis, an increased risk of SCCHN is associated with DNA repair and DNA stabilization genes. In addition, the polymorphisms involved in inflammation and carcinogenic metabolism processes represent an increased risk of SCCHN.
authors.affiliation: Departamento de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina. Electronic address: brunottomabel@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Brunotto
authors.affiliation: Departamento de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina.
authors.forename: A M
authors.initials: AM
authors.lastname: Zarate
authors.affiliation: Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Bono
authors.affiliation: CIQUIBIC, UNC-CONICET, Departamento de Química Biológica, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
authors.forename: J L
authors.initials: JL
authors.lastname: Barra
authors.affiliation: Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Universidad Nacional de Córdoba, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Berra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055815:Young Adult
keywords: Head and neck cancer; Meta-analysis; Risk polymorphisms; Systematic review