title: Role of intracellular Ca2+ and Na+/Ca2+ exchanger in the pathogenesis of contrast-induced acute kidney injury.
abstract: The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca(2+) overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca(2+) channel (VDC) and Na(+)/Ca(2+) exchanger (NCX) system are the main pathways of intracellular Ca(2+) overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca(2+) overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Dingping
authors.initials: D
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Dingwei
authors.initials: D
authors.lastname: Yang
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D019831:Sodium-Calcium Exchanger; D002118:Calcium