title: Paget disease of bone in Japanese patients: a report of three cases.
abstract: Paget disease of bone (PDB) is a bone metabolic disorder causing pain, fractures, and deformity. Its incidence is estimated to be 1 to 2% in Caucasians older than 55 years, but in Asian populations the incidence is rare. We report on 2 female and one male Japanese patients aged 46 to 73 years with PDB. One patient had monostotic disease with pain around the shoulder and the other 2 were asymptomatic. All patients had elevated alkaline phosphatase (ALP) levels (range, 629-957 U/L). Two patients responded to oral bisphosphonate treatment and achieved normalised ALP levels and pain relief. One patient with polyostotic disease did not show any change in ALP levels. The diagnosis of the disease and the indications for bisphosphonate treatment are discussed.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagano
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yokouchi
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Nagayoshi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shimada
authors.forename: Takao
authors.initials: T
authors.lastname: Setoguchi
authors.forename: Kosei
authors.initials: K
authors.lastname: Ijiri
authors.forename: Setsuro
authors.initials: S
authors.lastname: Komiya
mesh_terms: D000368:Aged; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D004164:Diphosphonates
keywords: alkaline phosphatase; diphosphonates; osteitis deformans