title: Stereocontrolled synthesis and functionalization of cyclobutanes and cyclobutanones.
abstract: In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000-2013.
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, complesso universitario di Monserrato, S.S. 554, bivio per Sestu, Monserrato 09042, CA, Italy. fsecci@unica.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Secci
authors.forename: Angelo
authors.initials: A
authors.lastname: Frongia
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Piras
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D003503:Cyclobutanes