title: Efficacy and safety of accelerated partial breast irradiation after breast-conserving surgery: a meta-analysis of published comparative studies.
abstract: To compare the treatment outcomes between accelerated partial breast irradiation (APBI) and conventional whole-breast irradiation (WBI) and to explore the efficacy and safety of APBI as an adjuvant treatment for early-stage breast cancer who received breast-conserving therapy. Eligible studies were identified on Medline, Embase, and the Cochrane Library updated to July 10, 2012. Comparative studies were considered for inclusion. Analyses were carried out using Stata software. Eleven comparative studies with a total of 7,097 patients were included. The meta-analysis showed that there were no statistically significant differences between group APBI and group WBI associated with the supraclavicular failure, distant metastasis, overall survival, and disease-free survival, while local recurrence (LR) and axillary failure (AF) increased in group APBI. The sensitivity analysis indicated that both the LR and AF were not statistically significant difference between the two groups. In the subgroup analysis, LR was statistically significantly higher in group APBI for patients with the age <60, large tumor size, and unknown margin status. APBI is a safe treatment modality and could become a potential option for the delivery of adjuvant radiation therapy in patients receiving breast-conserving therapy, especially for the suitable group that was classified by the American Society of Radiation Oncology Consensus Panel.
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, China; Shandong Academy of Medical Sciences, Jinan, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Kong
authors.forename: Jian
authors.initials: J
authors.lastname: Cheng
authors.forename: Xiuping
authors.initials: X
authors.lastname: Ding
authors.forename: Baosheng
authors.initials: B
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Hongfu
authors.initials: H
authors.lastname: Sun
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017594:Publication Bias; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: accelerated partial breast irradiation; breast cancer; breast-conserving therapy; meta-analysis; whole-breast irradiation