title: Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.
abstract: A libraries from libraries approach is described for the synthesis of five different sulfonamide linked scaffolds. Four of the scaffolds are sulfonamides linked to heterocycles; piperazine, thiourea, cyclic guanidine, and dimethyl cyclic guanidine. The fifth scaffold is a polyamine linked sulfonamide. Three different diversity positions were effectively incorporated into each scaffold providing a number of different compounds with good yields and purity.
authors.affiliation: Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.
authors.forename: Ginamarie
authors.initials: G
authors.lastname: Debevec
authors.affiliation: Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987 ; Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
authors.forename: Wenteng
authors.initials: W
authors.lastname: Chen
authors.affiliation: Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Houghten
authors.affiliation: Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Giulianotti
keywords: guanidine; libraries from libraries; piperazine; positional scanning; sulfonamide; urea