title: Human papillomavirus infection a favorable prognostic factor in laryngeal squamous cell carcinoma is associated with the expression of proliferating cell nuclear antigen.
abstract: OBJECTIVE
  It has been documented that human papilloma virus (HPV) DNA replication requires proliferating cell nuclear antigen (PCNA). However the association between them in tumors is still controversial. Up to now, the role of HPV in laryngeal squamous cell carcinoma (LSCC) has not been clearly established, and the correlation between HPV and PCNA in LSCC remains poorly explored.
  
  
  METHODS
  We retrospectively reviewed the clinicopathological features and follow-up data of 71 patients with LSCC. The lesions were examined for PCNA using immunohistochemistry, and for HPV using in situ hybridization.
  
  
  RESULTS
  31 (43.7%) cases showed infection of HPV and 38 (53.5%) showed overexpression of PCNA. No significant difference of HPV status in clinicopathological features was found. While there was a significant difference of PCNA expression in histology grade but no significant difference of PCNA expression in other clinicopathological features could be detected, and the expression of PCNA is not a significant predictor of survival in LSCC patients. However, HPV infection is a favorable prognostic factor in LSCC patients. Moreover, HPV infection is associated with PCNA overexpression.
  
  
  CONCLUSIONS
  Human papilloma virus (HPV) infection is an indicator of better prognosis in LSCC and associated with the expression of PCNA.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Peng-Fang
authors.initials: PF
authors.lastname: Lin
keywords: Human papillomavirus; Laryngeal squamous cell carcinoma; Prognosis; Proliferating cell nuclear antigen