title: [Tuberculosis: plasma levels of vitamin D and its relation with infection and disease].
abstract: OBJECTIVE
  Vitamin D (vitD) is involved in the phosphor-calcium metabolism and bone pathology, but also in inflammatory and infectious processes such as tuberculosis. The present study evaluates the clinical and epidemiological aspects of active tuberculosis cases and latently infected contacts in whom plasma concentrations of vitD were obtained to determine whether the deficiency of vitD is a risk factor to develop active tuberculosis, especially the more severe forms.
  
  
  METHODS
  Observational, retrospective study that included 86 tuberculosis patients and 80 contacts with latent infection in a 2-year period.
  
  
  RESULTS
  When comparing active tuberculosis cases with latent infection contacts, deficiency of vitD (vitD levels <10 ng/mL, odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.04 to 3.93), male sex (OR: 1.9, 95% CI: 0.96 to 3.71) and non-white race (OR: 0.7, 95% CI: 0.34 to 1.42) were factors independently associated with the diagnosis of tuberculosis.
  
  
  CONCLUSIONS
  Despite the limited number of subjects studied, there was a association between severe deficit of vitD and the presentation of tuberculosis.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital del Mar, Parc de Salut Mar, Barcelona, España.
authors.forename: Erika
authors.initials: E
authors.lastname: Esteve Palau
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital del Mar, Parc de Salut Mar, Barcelona, España. Electronic address: 97816@parcdesalutmar.cat.
authors.forename: Francesca
authors.initials: F
authors.lastname: Sánchez Martínez
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital del Mar, Parc de Salut Mar, Barcelona, España.
authors.forename: Hernando
authors.initials: H
authors.lastname: Knobel Freud
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital del Mar, Parc de Salut Mar, Barcelona, España.
authors.forename: José-Luís
authors.initials: JL
authors.lastname: López Colomés
authors.affiliation: Servicio de Medicina Interna, Hospital del Mar, Parc de Salut Mar, Barcelona, España.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Diez Pérez
mesh_terms: D000328:Adult; D015897:Comorbidity; D004198:Disease Susceptibility; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D055985:Latent Tuberculosis / Q000097:blood / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D044469:Racial Groups / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D014376:Tuberculosis / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology; D014804:Vitamin B Deficiency / Q000097:blood / Q000453:epidemiology / Q000208:ethnology; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D014807:Vitamin D
keywords: Concentración plasmática; Tuberculosis; Vitamin D: Plasma concentration; Vitamina D