title: [Insulin treatment in children with type one diabetes].
abstract: In all age groups, the aim of insulin treatment will be as close to physiological insulin replacement as possible in order to obtain optimum metabolic control. Rapid and long acting insulin analogs represent some improvement in the care of diabetes in children by improving glycaemic control and decreasing the occurrence of hypoglycaemia. Insulin dosage will be determined to allow appropriate insulin levels throughout the twenty-four hours to cover basal requirements and higher levels of insulin in an attempt to match the glycaemic effect of meals. The distribution of insulin dose across the days shows great individual variations and daily insulin dosage varies greatly between individuals end changes over time. Regardless of mode of insulin therapy, doses should be adapted based on the daily pattern of blood glucose and therefore require regular review and assessment. The device used for insulin administration must be adapted for paediatric patients. Whatever insulin regimen is chosen it must be supported by comprehensive education adapted for the age, maturity and individual needs of the child and family.
authors.affiliation: Unité d'endocrinologie, gynécologie et diabétologie pédiatrique, hôpital universitaire Necker-Enfants-Malades, Paris, France; Faculté de médecine Paris-Descartes, Paris, France; Inserm U845, unité affiliation IMAGINE, Paris, France. Electronic address: jacques.beltrand@nck.aphp.fr.
authors.forename: J
authors.initials: J
authors.lastname: Beltrand
authors.affiliation: Unité d'endocrinologie, gynécologie et diabétologie pédiatrique, hôpital universitaire Necker-Enfants-Malades, Paris, France; Faculté de médecine Paris-Descartes, Paris, France; Inserm U845, unité affiliation IMAGINE, Paris, France.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Robert
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007328:Insulin