title: [Analysis of clinical factors affecting pregnancy rate of intrauterine insemination].
abstract: OBJECTIVE
  To analyze the factors affecting clinical pregnancy rate of intrauterine insemination in Center of Reproductive Medicine, Peking University Third Hospital, to guide clinical treatment.
  
  
  METHODS
  In the study, 5 167 intrauterine insemination cycles were retrospectively analyzed from May 2011 to October 2012 in our reproductive center. The data were collected, the single-factor was analyzed with χ2 test, and the multi-factor was analyzed with Logistic regression with a significant level of 0.05.
  
  
  RESULTS
  The cycle clinical pregnancy rate was 12.8%, which decreased with the increase of the female age and infertile duration. The clinical pregnancy rate was low when the sperm density was less than 1×10(6)/mL. In the ovulation group, the clinical pregnancy rate was higher than the natural group. The group with more than 2 dominant follicles had higher clinical pregnancy rate as compared with the single dominant follicle group. The clinical pregnancy rate was the highest in the third cycle but decreased after the fourth cycle. The clinical pregnancy rate was higher in cervical factors, sexual dysfunction, and polycystic ovary than in the group with other reasons.
  
  
  CONCLUSIONS
  The female age, infertile duration, ovarian stimulation and follicle number, cause of infertility were the main factors affecting clinical pregnancy outcome; the sperm density, and cycle numbers have influence too; the insemination timing, and frequency have little effect.
authors.affiliation: Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Eduction, Beijing 100191, China.
authors.forename: Yang-ying
authors.initials: YY
authors.lastname: Xu
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xin-na
authors.initials: XN
authors.lastname: Chen
authors.forename: Cai-hong
authors.initials: CH
authors.lastname: Ma
authors.forename: Xiao-guo
authors.initials: XG
authors.lastname: Lin
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D008597:Menstrual Cycle; D008875:Middle Aged; D006080:Ovarian Follicle / Q000502:physiology; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013076:Sperm Count; D013081:Sperm Motility; D055815:Young Adult