title: Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses.
abstract: Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real world, a variety of definitions are being used by different groups and by different core laboratories to analyze OCT findings because of different clinical/procedural contexts in which OCT research has been carried out. This comprehensive overview is aimed to summarize different applicable definitions used by different research groups in plaque and stent analysis using OCT. In addition, it presents readers with a panoramic view to select the best definition of OCT measurement for one's own study purpose. We divided this review article into two parts: Part I - Plaque analysis, and Part II - Stent analysis. The plaque analysis section summarizes the definitions of plaque composition, rupture, erosion, protruding calcific nodules, macrophages, microvessels, and cholesterol crystal. The stent analysis section includes the classification of stent struts, features of neointimal hyperplasia, and other stent-related findings such as tissue protrusion, thrombus, intrastent, and stent edge dissections. In each case of controversy, an explanation for the specific context is provided.
authors.affiliation: aDepartment of Cardiovascular Medicine, Policlinico A. Gemelli, Catholic University of the Sacred Heart bInterventional Cardiology Unit, San Giovanni Addolorata Hospital and C.L.I. Foundation, Rome cCentre for Inherited Cardiovascular Diseases, Transplant Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy dHarvard Medical School, Beth Israel Deaconess Medical Center eHarvard Medical School, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts fUniversity Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio gZena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Vito
authors.forename: Joo Heung
authors.initials: JH
authors.lastname: Yoon
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Taishi
authors.initials: T
authors.lastname: Yonetsu
authors.forename: Rocco
authors.initials: R
authors.lastname: Vergallo
authors.forename: Marco
authors.initials: M
authors.lastname: Costa
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.forename: Eloisa
authors.initials: E
authors.lastname: Arbustini
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
authors.forename: Francesco
authors.initials: F
authors.lastname: Prati
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
mesh_terms: D003324:Coronary Artery Disease / Q000473:pathology* / Q000628:therapy*; D023903:Coronary Restenosis / Q000209:etiology / Q000473:pathology; D003328:Coronary Thrombosis / Q000209:etiology / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D058426:Neointima; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D015607:Stents; D009626:Terminology as Topic; D041623:Tomography, Optical Coherence / Q000145:classification*; D016896:Treatment Outcome