title: Organocatalytic enantioselective vinylogous Michael reaction of vinylketene silyl-N,O-acetals.
abstract: The enantioselective vinylogous Michael reaction of vinylketene silyl N,O-acetals derived from α,β-unsaturated N-acyl pyrroles and a broad range of α,β-unsaturated aldehydes proceeds with good regio-, diastereo-, and enantioselectivity when the Hayashi-Jørgensen diphenylprolinolsilylether was employed as a chiral organocatalyst. Products were obtained in generally good yields and as single stereoisomers after chromatographic purification with very high optical purity. They were easily derivatized into a set of useful synthetic building blocks.
authors.affiliation: Institut für Organische Chemie, Universität Leipzig , Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Smita
authors.initials: S
authors.lastname: Basu
authors.forename: Vaishali
authors.initials: V
authors.lastname: Gupta
authors.forename: Johannes
authors.initials: J
authors.lastname: Nickel
authors.forename: Christoph
authors.initials: C
authors.lastname: Schneider