title: Protective Effect of Aqueous Extract of Terminalia arjuna against Dehydrating Induced Oxidative Stress and Uremia in Male Rat.
abstract: The present study has been designed to find out the protective effect of aqueus extract of Terminalia arjuna against dehydration induced oxidative stress and uremia, protection by plant extract in male Wister strain albino rats, and therefore to find out the scientific basis of local use of Terminalia arjuna bark extract by village ayurved doctors to protect the progressive kidney disorder (renal failure) relating to dehydration and other related problems. Water withdrawing for 15 days in male Wister strain albino rats resulted in a significant elevation in the level of blood nitrogenous products (i.e. urea and creatinine). On the other hand, it increased the levels of free radicals, melondialdehyde (MDA) and conjugated dienes (CD) along with a significant diminution in the activities of superoxide dismutse (SOD) and catalase in blood. All these water markers were significantly prevented after administration of aqueous extract of Terminalia arjuna bark. These results suggest that dehydration induced oxidative stress and uremia in male rats may be protected by using the above mentioned medicinal plants extract. This herbal extract showed no toxic effect on blood and kidney, based on the measurements of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities (data not shown).
authors.affiliation: Department of Human Physiology and Department of Nutrition, Raja N L Khans Women's College, Midnapore, West Bengal, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Das
authors.affiliation: Post Graduate Department of Zoology, West Bengal, India.
authors.forename: Partha
authors.initials: P
authors.lastname: Pratim Chakraborty
authors.affiliation: Department of Biomedical Laboratory Science and Management, Vidyasagar University, West Bengal, India.
authors.forename: Debidas
authors.initials: D
authors.lastname: Ghosh
authors.affiliation: Department of Human Physiology and Department of Nutrition, Raja N L Khans Women's College, Midnapore, West Bengal, India. ; Dialysis Unit,Vidyasagar Institute of Health, West Bengal, India.
authors.forename: Dilip
authors.initials: D
authors.lastname: Kumar Nandi
keywords: Ayurvedic; Dehydration; Oxidative stress; Reactive oxygen species; Renal failure; Terminalia arjuna; Uremia