title: Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer.
abstract: To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted in vitro and in vivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic-co-glycolic acid)-Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10 min, which caused an increase in temperature to 45 °C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemo-photothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors.
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Severance Biomedical Science Institute, Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
authors.forename: Sook Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Severance Biomedical Science Institute, Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Kwon
authors.affiliation: Department of Microbiology, Severance Biomedical Science Institute, Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
authors.forename: Sol
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
authors.forename: Arthur
authors.initials: A
authors.lastname: Cho
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
authors.forename: Mijin
authors.initials: M
authors.lastname: Yun
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, South Korea; Department of Microbiology, Severance Biomedical Science Institute, Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 120-752, South Korea. Electronic address: jsshin6203@yuhs.ac.
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Shin
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, South Korea; Department of Physics, Yonsei University, Seoul 120-749, South Korea. Electronic address: khyoo@yonsei.ac.kr.
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Yoo
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004337:Drug Carriers; D019008:Drug Resistance, Neoplasm; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D051379:Mice; D008819:Mice, Nude; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D006046:Gold
keywords: Chemo-photothermal treatment; Multidrug resistance; Multifunctional nanoparticle; Near infrared resonance; Photothermally controlled drug delivery