title: [Expression of CDK6 in nasopharyngeal carcinoma and its clinical significance].
abstract: OBJECTIVE
  To explore the expression of CDK6 in nasopharyngeal carcinoma (NPC) and explore its clinical significance.
  
  
  METHODS
  Immunohistochemistry was used to examine the differential expression of CDK6 protein in 101 NPC and 30 nasopharyngeal tissues, and the correlation of CDK6 expression with the clinical characteristics was analyzed in NPC cases.
  
  
  RESULTS
  Immunohistochemistry demonstrated that CDK6 protein was a co-expressed factor in the cytoplasm and cell nuclei. CDK6 was expressed predominantly in the cytoplasm in nasopharyngeal tissues, but in NPC tissues, CDK6 was co-expressed predominantly in the cytoplasm and nuclei. Compared to the nasopharyngeal tissues, NPC tissues showed significantly up-regulated CDK6 expression (P=0.009) in positive correlation with tumor size (P=0.020) and clinical stages (P=0.0039).
  
  
  CONCLUSIONS
  Increased CDK6 protein expression is an unfavorable factor that promotes the development and progression of NPC.
authors.affiliation: Department of Otorhinolaryngology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China. E-mail: yyfyentlxp@163.com.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Luo
authors.forename: Jixin
authors.initials: J
authors.lastname: Qin
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Huaifei
authors.initials: H
authors.lastname: Wang
authors.forename: Jiajun
authors.initials: J
authors.lastname: Chen
mesh_terms: D002277:Carcinoma; D002467:Cell Nucleus; D051361:Cyclin-Dependent Kinase 6 / Q000378:metabolism*; D003593:Cytoplasm; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C495911:CDK6 protein, human; D051361:Cyclin-Dependent Kinase 6