title: Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.
abstract: Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr-old male patient. Remarkably, treatment with a high-dose cytarabine regimen led to rapid remineralization of all bone lesions and recovery of the patient's mobility within a few weeks. Thereby, surgical treatment and radiotherapy could be avoided, supporting the role of intensive induction and standard consolidation chemotherapy as first-line treatment for myeloid sarcoma.
authors.affiliation: Department II of Internal Medicine, University of Cologne, Cologne, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brähler
authors.forename: Indra
authors.initials: I
authors.lastname: Thielen
authors.forename: Hendrik
authors.initials: H
authors.lastname: Schwabe
authors.forename: Marianne
authors.initials: M
authors.lastname: Engels
authors.forename: Karl-Anton
authors.initials: KA
authors.lastname: Kreuzer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wolf
authors.forename: Sascha
authors.initials: S
authors.lastname: Ansén
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001847:Bone Diseases / Q000175:diagnosis / Q000209:etiology*; D001853:Bone Marrow / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology*; D003561:Cytarabine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine
keywords: extramedullary AML; myeloid sarcoma; treatment