title: Immunological principles regulating immunomodulation with biomaterials.
abstract: The immune system has evolved to recognize and eliminate pathogens; this recognition relies on the identification of structural molecular patterns within unique tissue microenvironments. Therefore, bioengineers can harness these immunological cues to design materials that modulate innate and adaptive immunity in a controlled manner. This review acts as an immunology primer by focusing on the basic molecular and cellular immunology principles governing immunomodulation with biomaterials.
authors.affiliation: ETH Zürich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland.
authors.forename: Tarik A
authors.initials: TA
authors.lastname: Khan
authors.affiliation: ETH Zürich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland. Electronic address: sai.reddy@bsse.ethz.ch.
authors.forename: Sai T
authors.initials: ST
authors.lastname: Reddy
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D056747:Immunomodulation / Q000187:drug effects*; D015166:Monitoring, Immunologic
chemical_list: D001672:Biocompatible Materials
keywords: Adjuvants; Immunoengineering; Immunology; Vaccine delivery