title: A new bis-labdanic diterpene from the rhizomes of Alpinia pahangensis.
abstract: The rhizomes of Alpinia pahangensis yielded a new bis-labdanic diterpene for which the name pahangensin C (1) was proposed along with twelve known analogues (2-13). The structure of 1 was elucidated via spectroscopic methods including 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2 and 12 were isolated for the first time from the genus Alpinia. This is the second occurrence of compounds 2 and 12 in the Zingiberaceae family. Selected analogues exhibited moderate to strong inhibitory activity against Staphylococcus aureus and Bacillus cereus.
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Sivasothy
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Halijah
authors.initials: H
authors.lastname: Ibrahim
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Audra Shaleena
authors.initials: AS
authors.lastname: Paliany
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Siti Aisyah
authors.initials: SA
authors.lastname: Alias
authors.affiliation: Chemistry Department, Center of Foundation Studies, International Islamic University Malaysia, Selangor, Malaysia.
authors.forename: Nurur Raudzah
authors.initials: NR
authors.lastname: Md Nor
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000900:Anti-Bacterial Agents; D001409:Bacillus cereus / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts