title: Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.
abstract: The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.
authors.affiliation: Centre National de la Recherche Scientifique (CNRS) UMR 8119 Neurophysics and Physiology Laboratory, Université Paris Descartes, Paris, France.
authors.forename: Visou
authors.initials: V
authors.lastname: Ady
authors.forename: Julie
authors.initials: J
authors.lastname: Perroy
authors.forename: Ludovic
authors.initials: L
authors.lastname: Tricoire
authors.forename: Claire
authors.initials: C
authors.lastname: Piochon
authors.forename: Selma
authors.initials: S
authors.lastname: Dadak
authors.forename: Xiaoru
authors.initials: X
authors.lastname: Chen
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dusart
authors.forename: Laurent
authors.initials: L
authors.lastname: Fagni
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lambolez
authors.forename: Carole
authors.initials: C
authors.lastname: Levenes
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002531:Cerebellum / Q000166:cytology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D015640:Ion Channel Gating; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011690:Purkinje Fibers / Q000187:drug effects / Q000502:physiology; D017470:Receptors, Glutamate / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D012118:Resorcinols / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D017470:Receptors, Glutamate; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C107913:glutamate receptor delta 2; C079215:3,5-dihydroxyphenylglycine; D005998:Glycine