title: Ion concentration polarization-based continuous separation device using electrical repulsion in the depletion region.
abstract: We proposed a novel separation method, which is the first report using ion concentration polarization (ICP) to separate particles continuously. We analyzed the electrical forces that cause the repulsion of particles in the depletion region formed by ICP. Using the electrical repulsion, micro- and nano-sized particles were separated based on their electrophoretic mobilities. Because the separation of particles was performed using a strong electric field in the depletion region without the use of internal electrodes, it offers the advantages of simple, low-cost device fabrication and bubble-free operation compared with conventional continuous electrophoretic separation methods, such as miniaturizing free-flow electrophoresis (μ-FFE). This separation device is expected to be a useful tool for separating various biochemical samples, including cells, proteins, DNAs and even ions.
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, the Republic of Korea.
authors.forename: Hyungkook
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, the Republic of Korea.
authors.forename: Horim
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, the Republic of Korea.
authors.forename: Kwan Hyoung
authors.initials: KH
authors.lastname: Kang
authors.affiliation: 1] Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, the Republic of Korea [2] Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, the Republic of Korea.
authors.forename: Geunbae
authors.initials: G
authors.lastname: Lim