title: [Can we prevent or cure infection-related cancers?].
abstract: Infections are an important cause of cancer in the world, representing approximately 16% of the neoplasia. Ten infectious agents have been classified as carcinogens of group I. Four of these pathogens (Helicobacter pylori, hepatitis B and C viruses, and some human papillomavirus) are responsible for 95% of cases of infection-related cancers. The carcinogenesis mechanisms are multiple, either direct via certain proteins from these microorganisms, or more often indirect through chronic inflammation. This allowed to consider prevention of certain cancers, for example with a prophylactic vaccine strategy. Advances were also made in the curative field. However, efforts remain to be done to discover new infectious causes of cancer and refine the understanding of the mechanisms of carcinogenesis, for a better targeting of anticancer therapeutics.
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: oncologie@sainteanne.org.
authors.forename: O
authors.initials: O
authors.lastname: Gisserot
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Romeo
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Boudin
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Tsitsi Nding Tsogou
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: S
authors.initials: S
authors.lastname: Abed
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: J-S
authors.initials: JS
authors.lastname: Bladé
authors.affiliation: Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: de Jauréguiberry
mesh_terms: D002472:Cell Transformation, Viral; D016481:Helicobacter Infections / Q000150:complications / Q000628:therapy; D016480:Helicobacter pylori; D006518:Hepatitis Viruses / Q000472:pathogenicity; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications / Q000628:therapy; D012074:Remission Induction; D014611:Vaccination / Q000379:methods; D014777:Virus Diseases / Q000150:complications* / Q000453:epidemiology / Q000628:therapy*
keywords: Cancer; Infections; Oncogenesis; Oncogenèse; Prevention; Prévention