title: Clinical and prognostic importance of XIAP and USP8 in advanced stages of non-small cell lung cancer.
abstract: OBJECTIVE
  To investigate the relationship of the apoptosis regulators X-linked inhibitor of apoptosis (XIAP) and ubiquitin specific protease 8 (USP8) with clinical parameters, survival and response to chemotherapy in patients with advanced stages of non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The study included 34 NSCLC patients (28 females, 6 males) and 44 healthy individuals (17 males, 27 females) as a control group. XIAP and USP8 levels were determined by ELISA.
  
  
  RESULTS
  The median serum XIAP level of the patients and the control group showed no significant difference. USP8 level was higher in patients than in controls (p<0.0001). In univariate analysis, there was no significant relationship between XIAP and USP8 serum levels and age, sex, performance status, weight loss, stage of disease, histopatological type and response to chemotherapy. Response to chemotherapy did not differ between the high and low XIAP and USP8 groups . There was no significant difference in progression- free survival (PFS) (p=0.432 and p=0.50, respectively) and overall survival (OS) (p=0.989 and p=0.90, respectively) between the low and high XIAP and USP8 groups.
  
  
  CONCLUSIONS
  No relationship was found in serum XIAP and USP8 levels with clinical parameters, response to chemotherapy, PFS and OS in patients with advanced stages of NSCLC.
authors.affiliation: Sakarya University Training and Research Hospital, Department of Medical Oncology, Sakarya, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Baykara
authors.forename: M
authors.initials: M
authors.lastname: Yaman
authors.forename: S
authors.initials: S
authors.lastname: Buyukberber
authors.forename: G
authors.initials: G
authors.lastname: Tufan
authors.forename: U
authors.initials: U
authors.lastname: Demirci
authors.forename: M
authors.initials: M
authors.lastname: Benekli
authors.forename: U
authors.initials: U
authors.lastname: Coskun
authors.forename: A
authors.initials: A
authors.lastname: Ozet
authors.forename: E
authors.initials: E
authors.lastname: Umit Bagriacik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D010450:Endopeptidases / Q000097:blood*; D056827:Endosomal Sorting Complexes Required for Transport / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D043222:Ubiquitin Thiolesterase / Q000097:blood*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D056827:Endosomal Sorting Complexes Required for Transport; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D010450:Endopeptidases; C541534:USP8 protein, human; D043222:Ubiquitin Thiolesterase