title: Glomerular diseases associated with cancer, chemotherapy, and hematopoietic stem cell transplantation.
abstract: Many solid and hematological malignancies have been associated with different glomerular diseases. Several case reports and case series of cancer-associated glomerular diseases have shown that treating the cancer may lead to resolution of the glomerular process. Hence, knowledge and approach to cancer-associated glomerular diseases is important for both the caring nephrologists and the cancer specialists. While membranous nephropathy has been classically associated with solid malignancies, minimal change disease has been commonly described with hematologic malignancies, especially non-Hodgkin's lymphoma. Membranoproliferative glomerulonephritis is increasingly being recognized to be associated with chronic hematologic malignancies such as chronic lymphocytic leukemia. In this article, we review various cancer-associated glomerular diseases and their pathogenesis as well as principles of treatment. In addition, we also review glomerular diseases seen after chemotherapy and hematopoietic stem cell transplantation.
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address: kdj200@gmail.com.
authors.forename: Kenar D
authors.initials: KD
authors.lastname: Jhaveri
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Hitesh H
authors.initials: HH
authors.lastname: Shah
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Chinmay
authors.initials: C
authors.lastname: Patel
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Aditya
authors.initials: A
authors.lastname: Kadiyala
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Stokes
authors.affiliation: Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000209:etiology / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D009369:Neoplasms / Q000150:complications*; D009402:Nephrosis, Lipoid / Q000209:etiology / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; Chemotherapy; Graft versus host disease; Hematopoietic stem cell transplantation; Paraneoplastic glomerulonephritis