title: Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents.
abstract: To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor cells and can even revert the resistance to cisplatin and vincristine. We also demonstrated that unsymmetrical diazenedicarboxamides 1 and 2 exhibited promising cytotoxicity. The aim of the present study was to synthesize new diazenedicarboxamides with acceptable solubility and good cytotoxicity. Here we report the synthesis and biological evaluation of new N,N'-disubstituted diazenedicarboxamides. We found that a modification of either 1 or 2 led to the more active compounds. The most effective among them was diazenedicarboxamide 11, which can be considered as a new potential anticancer agent for the tumors of different origin, as well as for the drug resistant tumors.
authors.forename: Jure
authors.initials: J
authors.lastname: Vajs
authors.forename: Sanja
authors.initials: S
authors.lastname: Soviček
authors.forename: Petra
authors.initials: P
authors.lastname: Kureljak
authors.forename: Nikolina
authors.initials: N
authors.lastname: Stojanović
authors.forename: Ivana
authors.initials: I
authors.lastname: Steiner
authors.forename: Domagoj
authors.initials: D
authors.lastname: Eljuga
authors.forename: Damijana
authors.initials: D
authors.lastname: Urankar
authors.forename: Marijan
authors.initials: M
authors.lastname: Kočevar
authors.forename: Janez
authors.initials: J
authors.lastname: Košmrlj
authors.forename: Slovenko
authors.initials: S
authors.lastname: Polanc
authors.forename: Maja
authors.initials: M
authors.lastname: Osmak
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001391:Azo Compounds / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D001391:Azo Compounds; D003998:Dicarboxylic Acids