title: Successful corticosteroid-sparing effect of rituximab in the treatment of refractory idiopathic orbital inflammatory disease.
abstract: Idiopathic orbital inflammatory disease (IOID) is an idiopathic inflammatory process within the orbit that can result in permanent visual impairment. Although high-dose oral corticosteroids are currently the mainstay of therapy, their long-term usage can cause significant toxicity. We present a case of IOID that was successfully treated with the anti-CD20 monoclonal antibody rituximab following failed steroid sparing with conventional second-line immunosuppressive agents.
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Guildford, London, UK.
authors.forename: Emily H
authors.initials: EH
authors.lastname: Shao
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Guildford, London, UK.
authors.forename: Andreas
authors.initials: A
authors.lastname: Karydis
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Guildford, London, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Gemenetzi
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Guildford, London, UK ; Faculty of Medicine, Imperial College London, London, UK.
authors.forename: Simon R J
authors.initials: SR
authors.lastname: Taylor
keywords: Idiopathic orbital inflammatory disease; Rituximab