title: Vacuolization, dilatation, hyaline cast, debris or degeneration: which one is the most correlated item to score the kidney damage pathologically in Cisplatin induced nephrotoxicity model?
abstract: BACKGROUND
  Nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. In this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (PDS) in Cisplatin-induced nephrotoxicity.
  
  
  METHODS
  A total of 207 normal and toxic rats' kidney tissue (induced by Cisplatin) were evaluated for toxicity intensity by two methods. In the first method, the tissue damage was scored from 0 to 4, and in the second method the percentage of vacuolization, dilatation, hyaline cast, debris or degeneration were determined. The data was analyzed using stepwise discriminant function and regression analysis.
  
  
  RESULTS
  The variables having the higher discriminant function coefficient were hyaline cast, dilatation, and degeneration. The linear regression model and the prediction function to determine the kidney tissue PDS were generated as below. [Formula: see text].
  
  
  CONCLUSIONS
  According to this finding it is suggested that presence of hyaline cast and dilatation, and then degeneration in the sample of toxic renal tissue are the most important item to score the damage intensity.
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ashrafi
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Isfahan Institute of Basic and Applied Sciences Research, Isfahan, IR Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Isfahan Institute of Basic and Applied Sciences Research, Isfahan, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Sayed Mohsen
authors.initials: SM
authors.lastname: Hosseini
authors.affiliation: Depatrment of Industrial Engineering, Tarbiat Moddaress University, Tehran, IR Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ashrafi
keywords: Degeneration; Dilatation; Hyaline; Kidney Failure, Chronic