title: The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects.
abstract: OBJECTIVE
  To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with co-morbid borderline personality disorder (BPD) in female heroin-dependent patients.
  
  
  METHODS
  In a case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 296 female heroin-dependent patients (including 61 patients with BPD and 235 without BPD) and 101 normal females by genotypes, alleles, and interaction between genes.
  
  
  RESULTS
  Female heroin-dependent subjects with BPD have lower frequency of the high activity allele (L: 4 repeats (4R)) of MAOA-LPR than those female heroin-dependent subjects without BPD, and have higher 5-HTTVNTR 10R/10R genotype frequency than normal female controls, with adjusted P-value<0.05 (after adjusted for multiple testing by 1000-fold permutation tests) respectively. By MDR (Multifactor Dimensionality Reduction) analyses, the interactive effects between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 were close to the significance level (P=0.05) in predicting the risk of co-morbidity of BPD and heroin dependence relative to normal female controls, with 1000-fold permutation testing P-value<0.06 however >0.05 respectively.
  
  
  CONCLUSIONS
  5-HTTVNTR and MAOA-LPR may have independent predictive effects on co-morbid BPD in female heroin-dependent patients; the gene-gene interactions between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 might also be involved in the etiology of this co-morbidity.
authors.affiliation: Department of Social Medicine, School of Public Health, Central South University, Changsha, China; Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Social Medicine, School of Public Health, Central South University, Changsha, China.
authors.forename: Jules
authors.initials: J
authors.lastname: Mamy
authors.affiliation: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liao
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Vasish
authors.initials: V
authors.lastname: Seewoobudul
authors.affiliation: Department of Social Medicine, School of Public Health, Central South University, Changsha, China.
authors.forename: Shui-Yuan
authors.initials: SY
authors.lastname: Xiao
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: weihao57@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D001883:Borderline Personality Disorder / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D017831:Diagnosis, Dual (Psychiatry); D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D004843:Epistasis, Genetic / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006556:Heroin Dependence / Q000150:complications / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: Association study; Borderline personality disorder; Co-morbidity; Gene polymorphism; Heroin dependence