title: Small molecule screening in human induced pluripotent stem cell-derived terminal cell types.
abstract: A need for better clinical outcomes has heightened interest in the use of physiologically relevant human cells in the drug discovery process. Patient-specific human induced pluripotent stem cells may offer a relevant, robust, scalable, and cost-effective model of human disease physiology. Small molecule high throughput screening in human induced pluripotent stem cell-derived cells with the intent of identifying novel therapeutic compounds is starting to influence the drug discovery process; however, the use of these cells presents many high throughput screening development challenges. This technology has the potential to transform the way drug discovery is performed.
authors.affiliation: From Pharmacokinetics, Dynamics and Metabolism-New Chemical Entities, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Engle
authors.forename: Fabien
authors.initials: F
authors.lastname: Vincent
mesh_terms: D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D054852:Small Molecule Libraries / Q000032:analysis*
chemical_list: D054852:Small Molecule Libraries
keywords: Drug Action; Drug Development; Drug Discovery; Drug Screening; Stem Cells