title: Effects of the degree of obesity on achieving target blood pressure and metabolic deterioration in obese individuals: a population-based study.
abstract: OBJECTIVE
  This study aimed to evaluate the severity of obesity and its impact on achieving target blood pressure and metabolic derangement in obese individuals.
  
  
  METHODS
  This cross-sectional and population-based study was conducted between January and December 2012. A total of 1837 consecutive obese patients admitted to our outpatient clinic were enrolled. The anthropometric and blood pressure measurements, bioelectrical impedance fat analysis, blood sample analysis, impaired glucose status, metabolic syndrome, and insulin resistance of 1265 obese patients were compared between groups of patients separated by severity of obesity.
  
  
  RESULTS
  Only approximately one-third of patients with previous hypertension achieved normal blood pressure. In addition, the majority of patients without previous hypertension had higher blood pressure at the end of the study compared with baseline. The percent of patients with an impaired fasting blood glucose ≥100 mg/dL was 38.5%. The frequency of impaired glucose tolerance was 39.1% in the patients who underwent OGTT Body mass index (BMI) was associated with impaired blood glucose, hypertension, insulin resistance, and the development of metabolic syndrome. The incidences of metabolic syndrome, insulin resistance, impaired glucose tolerance, and uncontrolled blood pressure were significantly different between groups of differing obesity severity (p<0.001, p<0.001, p=0.041, and p<0.001, respectively).
  
  
  CONCLUSIONS
  The severity of obesity was associated with the failure to achieve target blood pressure and metabolic syndrome. Based on our data, blood pressure and metabolic parameters in obese patients should be monitored frequently and treated with caution.
authors.affiliation: Abant Izzet Baysal University, School of Medicine, Department of Cardiology, Bolu, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozturk
authors.forename: Davut
authors.initials: D
authors.lastname: Baltaci
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Turker
authors.forename: Ali
authors.initials: A
authors.lastname: Kutlucan
authors.forename: Erhan
authors.initials: E
authors.lastname: Yengil
authors.forename: Mehmet Harun
authors.initials: MH
authors.lastname: Deler
authors.forename: Mucahit
authors.initials: M
authors.lastname: Gur
authors.forename: Handan
authors.initials: H
authors.lastname: Ankarali
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D011159:Population Surveillance / Q000379:methods