title: Killer immunoglobulin-like receptor and their HLA ligands in Guillain-Barré Syndrome.
abstract: Guillain-Barré Syndrome (GBS) is an inflammatory neuropathy that occurs in some individuals after exposure to an infectious illness. We investigated the role of Killer-immunoglobulin-like receptors (KIR) and their HLA ligands as potential genetic factors in the pathogenesis of GBS. These receptors are involved in the innate immune response to infections. Whilst no significant differences in the frequencies KIR genes were found, HLA-C2 and HLA-B Bw4-T were more frequent in subjects with GBS than controls (p<0.001). The inhibitory pairs KIR-2DL2/HLA-C2 and KIR-3DL1/HLA-B Bw4-T were more frequent in GBS than controls (all p<0.005). We propose that NK cell inhibition is an important factor in the pathogenesis of GBS.
authors.affiliation: Royal Brisbane and Women's Hospital, Department of Neurology, Herston, QLD 4029, Australia; University of Queensland, Centre of Clinical Research, Herston Campus, Herston, QLD 4029, Australia. Electronic address: stefan_blum@health.qld.gov.au.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blum
authors.affiliation: University of Queensland, Centre of Clinical Research, Herston Campus, Herston, QLD 4029, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Csurhes
authors.affiliation: Concord Repatriation General Hospital, Concord, NSW 2139, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Reddel
authors.affiliation: Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
authors.forename: Judy
authors.initials: J
authors.lastname: Spies
authors.affiliation: Royal Brisbane and Women's Hospital, Department of Neurology, Herston, QLD 4029, Australia; University of Queensland, Centre of Clinical Research, Herston Campus, Herston, QLD 4029, Australia.
authors.forename: Pamela
authors.initials: P
authors.lastname: McCombe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000473:pathology*; D015236:HLA-C Antigens / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D008024:Ligands; D008297:Male; D008875:Middle Aged; D054340:Receptors, KIR / Q000378:metabolism*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I; D008024:Ligands; D054340:Receptors, KIR
keywords: Gene frequency; Guillain-Barré syndrome; Histocompatibility antigens, Class I; Killer cells, Natural; Receptors, KIR