title: Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy.
abstract: The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer (verteporfin) dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue. An orthotopic pancreatic xenograft mouse model was used for the study. A strong correlation (r = 0.57) was found for bulk intensity measurements of T1-weighted gadolinium enhancement and verteporfin fluorescence in the tumor region of interest. The use of contrast-enhanced MR imaging shows promise as a method for treatment planning and photosensitizer dosimetry in human photodynamic therapy (PDT) of pancreas cancer.
authors.affiliation: Geisel School of Medicine at Dartmouth College, Department of Surgery, Lebanon, New Hampshire 03756bDartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755.
authors.forename: Kimberley S
authors.initials: KS
authors.lastname: Samkoe
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755.
authors.forename: Amber
authors.initials: A
authors.lastname: Bryant
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Gunn
authors.affiliation: University College London, Institute for Liver and Digestive Health, London NW3 2QG, United Kingdom.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
authors.affiliation: Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114.
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Hasan
authors.affiliation: Geisel School of Medicine at Dartmouth College, Department of Surgery, Lebanon, New Hampshire 03756bDartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011874:Radiometry; D000077362:Verteporfin; D023041:Xenograft Model Antitumor Assays
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin