title: Pertactin-negative variants of Bordetella pertussis in New York State: a retrospective analysis, 2004-2013.
abstract: The first report of pertactin-negative variants of Bordetella pertussis in the United States has raised questions about the role of acellular pertussis vaccines in the recent increase of pertussis cases. Our laboratory utilized a sequence-based method to identify mutations in the pertactin gene responsible for these variants and assessed vaccination status from the associated cases.
authors.affiliation: Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201-2002, United States.
authors.forename: Tammy
authors.initials: T
authors.lastname: Quinlan
authors.affiliation: Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201-2002, United States.
authors.forename: Kimberlee A
authors.initials: KA
authors.lastname: Musser
authors.affiliation: Emerging Infections Program, New York State Department of Health, Albany, NY 12237, United States.
authors.forename: Salvatore A
authors.initials: SA
authors.lastname: Currenti
authors.affiliation: Emerging Infections Program, New York State Department of Health, Albany, NY 12237, United States.
authors.forename: Shelley M
authors.initials: SM
authors.lastname: Zansky
authors.affiliation: Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201-2002, United States. Electronic address: halse@wadsworth.org.
authors.forename: Tanya A
authors.initials: TA
authors.lastname: Halse
mesh_terms: D000293:Adolescent; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D001886:Bordetella pertussis / Q000145:classification / Q000235:genetics*; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D009154:Mutation; D009518:New York; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D010566:Virulence Factors, Bordetella / Q000235:genetics* / Q000378:metabolism; D014917:Whooping Cough / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C068929:pertactin
keywords: Acellular vaccine; Bordetella pertussis; Pertactin-negative variants