title: DNA-mediated construction of hollow upconversion nanoparticles for protein harvesting and near-infrared light triggered release.
abstract: A simple DNA-mediated solvothermal method has been developed for the construction of well-defined hollow UNPs that can be used for a new paradigm to realize NIR light-controlled non-invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living cells. Intracellular NIR triggers the release of enzymes with high spatial and temporal precision and the released enzyme also retains its biological activity.
authors.affiliation: State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Chen
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Meili
authors.initials: M
authors.lastname: Yin
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D001578:Benzopyrans / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004798:Enzymes / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007211:Indoles / Q000737:chemistry; D007259:Infrared Rays; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry; D010047:Ovalbumin / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D001578:Benzopyrans; D004798:Enzymes; D007074:Immunoglobulin G; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran; D010047:Ovalbumin; D004247:DNA; D001616:beta-Galactosidase
keywords: DNA; hollow particles; nanoparticles; near-infrared light; protein delivery; solvothermal method; upconversion