title: Extracellular activities of aminoacyl-tRNA synthetases: new mediators for cell-cell communication.
abstract: Over the last decade, many reports have discussed aminoacyl-tRNA synthetases (ARSs) in extracellular space. Now that so many of them are known to be secreted with distinct activities in the broad range of target cells including endothelial, various immune cells, and fibroblasts, they need to be classified as a new family of extracellular signal mediators. In this chapter the identity of the secreted ARSs, receptors, and their physiological and pathological implications will be described.
authors.affiliation: Medicinal Bioconvergence Research Center, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Son
authors.forename: Min Chul
authors.initials: MC
authors.lastname: Park
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D005110:Extracellular Space / Q000201:enzymology*; D006801:Humans
chemical_list: D016207:Cytokines; D000604:Amino Acyl-tRNA Synthetases