title: Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene.
abstract: The aim of this communication was to describe the detection of the coexistence of HIV-1 variant with dipeptide insertion between codons 69 and 70 of reverse transcriptase. These variants were isolated from a 16-year-old male patient, undergoing treatment in the city of Marilia, SP, Southeastern Brazil. After confirmation of treatment failure, resistance to antiretroviral drugs testing was performed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69S mutation. These insertions have low prevalence, have not been reported in situations of coexistence in Brazil and are related to multidrug resistance, which makes this epidemiological finding relevant.
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, BotucatuSP, Brasil.
authors.forename: Aline Aki
authors.initials: AA
authors.lastname: Tanikawa
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, BotucatuSP, Brasil.
authors.forename: Sarita Fiorelli Dias
authors.initials: SF
authors.lastname: Barreto
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Rejane Maria Tommasini
authors.initials: RM
authors.lastname: Grotto
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Maria Inês de Moura Campos
authors.initials: MI
authors.lastname: Pardini
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003062:Codon; D024882:Drug Resistance, Viral / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D003062:Codon; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase