title: Autologous collagen-induced chondrogenesis using fibrin and atelocollagen mixture.
abstract: For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p < 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.
authors.affiliation: Department of Orthopedic Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu City, Republic of Korea.
authors.forename: In Ho
authors.initials: IH
authors.lastname: Jeong
authors.forename: Asode Ananthram
authors.initials: AA
authors.lastname: Shetty
authors.forename: Seok Jung
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jae Deog
authors.initials: JD
authors.lastname: Jang
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Yang Guk
authors.initials: YG
authors.lastname: Chung
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Choi
authors.forename: Chung Hsuan
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000818:Animals; D002357:Cartilage Diseases / Q000628:therapy; D002470:Cell Survival / Q000187:drug effects; D020219:Chondrogenesis / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D005337:Fibrin / Q000494:pharmacology*; D006801:Humans; D007719:Knee Joint / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects; D013552:Swine
chemical_list: C059821:atelocollagen; D005337:Fibrin; D003094:Collagen