title: Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver.
abstract: OBJECTIVE
  To compare four imaging approaches in cirrhotic estimation; pre-enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal-based liver-to-muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography.
  
  
  METHODS
  Consecutive 58 patients with chronic liver diseases who underwent both Gd-EOB-DTPA-enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis.
  
  
  RESULTS
  RR was found to be inversely correlated with LSM (r = -0.65). RR decreased with degree of fibrosis (F0-F1, 58.5 ± 6.2%, versus F2-F3-F4, 48.8 ± 11.7%, P = 0.010, F0-F1-F2, 58.2 ± 6.2% versus F3-F4, 45.5 ± 12.3%, P = 0.010 and F0-F1, 58.5 ± 6.2%, versus F2-F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0-F1, 5.4 ± 2.2 kPa versus F2-F3-F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0-F1-F2, 6.8 ± 3.6 kPa versus F3-F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0-F1, 5.4 ± 2.2 kPa, versus F2-F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3-F4), 0.72 (F2-F3-F4), 0.68 (F2-F3) for RR and 0.83 (F3-F4), 0.88 (F2-F3-F4), 0.81 (F2-F3) for LSM in discriminating between patients with fibrosis.
  
  
  CONCLUSIONS
  The capability by LSM was better than those by RR of T1RT, pre-enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3.
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
authors.forename: Norihisa
authors.initials: N
authors.lastname: Yada
authors.forename: Kazushi
authors.initials: K
authors.lastname: Numata
authors.forename: Minori
authors.initials: M
authors.lastname: Onoda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hyodo
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Inoue
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002908:Chronic Disease; D003287:Contrast Media; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA; MRI; T1 relaxation time; US; elastography; liver fibrosis