title: Carotid Artery Intima Media Thickness and HsCRP; Predictors for Atherosclerosis in Prediabetic Patients?
abstract: OBJECTIVE
  We aimed to assess carotid intima media thickness (CIMT) and serum high-sensitivity C-reactive protein (hs-CRP) levels as estimated markers of subclinical atherosclerosis and inflammation in prediabetic patients.
  
  
  METHODS
  One hundred and ten patients were defined as prediabetic and seventy-six subjects (age and sex matched) were assigned as control group in our cross sectional study. Bilateral CIMT measurements and hs-CRP levels were evaluated.
  
  
  RESULTS
  The prevalance of hypertension, hyperlipidemia, angiotensin receptor blockers and antihyperlipidemic medication use were statistically higher in the prediabetic group. Serum hs-CRP levels, left, right and maximum CIMT were statistically higher among prediabetics compared to control group. There was a positive, significant correlation between left, right, maximum CIMT and fasting blood glucose, HbA1c, hs-CRP levels and BMI.
  
  
  CONCLUSIONS
  Recognising and focusing on the intervention of prediabetic state as early as possible and identifying the susceptible patients who may benefit from more aggressive preventive therapy is an important issue of primary prevention of diabetes and cardiovascular diseases.
authors.affiliation: Hulya Parildar, MD, Department of Family Medicine, Baskent University Istanbul Hospital, Istanbul, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Parildar
authors.affiliation: Oyku Gulmez, MD, Department of Cardiology, Baskent University Istanbul Hospital, Istanbul, Turkey.
authors.forename: Oyku
authors.initials: O
authors.lastname: Gulmez
authors.affiliation: Ozlem Cigerli, MD, Department of Family Medicine, Baskent University Istanbul Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cigerli
authors.affiliation: Asli Dogruk Unal, MD, Department of Endocrinology and Metabolism, Baskent University Istanbul Hospital, Istanbul, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Dogruk Unal
authors.affiliation: Rengin Erdal. MD, Department of Family Medicine, Baskent University, Ankara, Turkey.
authors.forename: Rengin
authors.initials: R
authors.lastname: Erdal
authors.affiliation: Nilgun Guvener Demirag, MD, Department of Endocrinology and Metabolism, Baskent University Istanbul Hospital, Istanbul, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Guvener Demirag
keywords: Carotid atherosclerosis; Inflammation; Prediabetes