title: The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations.
abstract: OBJECTIVE
  The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA.
  
  
  METHODS
  We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp's angle, and acetabular hip index were calculated.
  
  
  RESULTS
  Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA.
  
  
  CONCLUSIONS
  Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.
authors.affiliation: Center of Osteoporosis and Spinal Disorders: Kamimura Orthopaedic Clinic, Matsumoto, 399-0021, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Kamimura
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan ; Department of Orthopaedic Surgery, Showa Inan General Hospital, Komagane, 399-4117, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Ikegami
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan.
authors.forename: Keijiro
authors.initials: K
authors.lastname: Mukaiyama
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Uchiyama
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi3-1-1, Matsumoto, 390-8621, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
keywords: MRI; Pathophysiology; bone; hip osteoarthritis; joint pain.