title: [Loco-regional treatments of the metastatic sites for patients with pauci-metastatic cutaneous melanoma (without brain metastasis): French national guidelines].
abstract: BACKGROUND
  The last years are marked by the emergence of new molecules for the treatment of metastatic cutaneous melanoma with a significant benefit on the survival. Besides, some techniques are in development for the loco-regional treatment of the metastatic sites, bringing new therapeutic perspectives. However, their respective use and place in the therapeutic strategy are debated by healthcare professionals.
  
  
  OBJECTIVE
  The French National Cancer Institute leads a national clinical practice guidelines project since 2008. It realized a review of these modalities of treatment and developed recommendations.
  
  
  METHODS
  The clinical practice guidelines development process is based on systematic literature review and critical appraisal by a multidisciplinary expert workgroup. The recommendations are thus based on the best available evidence and expert agreement. Prior to publication, the guidelines are reviewed by independent practitioners in cancer care delivery.
  
  
  RESULTS
  This article presents recommendations for loco-regional treatments of the pulmonary, bone, cutaneous, hepatic and digestive metastatic sites for patients with pauci-metastatic cutaneous melanoma.
authors.affiliation: Hôpital Cavale Blanche, boulevard Tanguy-Prigent, 29609 Brest, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Sassolas
authors.affiliation: Institut du Cancer de Montpellier Val-d'Aurelle, parc Euromédecine, 208, avenue des Apothicaires, 34298 Montpellier, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Mourrégot
authors.affiliation: Centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Thariat
authors.affiliation: Centre hospitalier universitaire de Saint-Étienne, 42055 Saint-Étienne, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tiffet
authors.affiliation: Centre Georges-François-Leclerc, 1, rue du Professeur-Marion, BP 77980, 21079 Dijon, France.
authors.forename: Inna
authors.initials: I
authors.lastname: Dygai-Cochet
authors.affiliation: Centre Oscar-Lambret, 3, rue Frédéric-Combemale, BP 307, 59020 Lille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Mirabel
authors.affiliation: Centre Georges-François-Leclerc, 1, rue du Professeur-Marion, BP 77980, 21079 Dijon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Truc
authors.affiliation: Institut du Cancer de Montpellier Val-d'Aurelle, parc Euromédecine, 208, avenue des Apothicaires, 34298 Montpellier, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Cupissol
authors.affiliation: Hôpital Saint-Vincent-de-Paul, boulevard de Belfort, BP 387, 59020 Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Modiano
authors.affiliation: Centre Léon-Bérard, 28, rue Laënnec, 69008 Lyon, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Combemale
authors.affiliation: Hôpital Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoge, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bedane
authors.affiliation: Hôpital Charles-Nicolle, 1, rue de Germont, 76000 Rouen, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Derrey
authors.affiliation: Hôpital Purpan, place Baylac, 31059 Toulouse, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Lamant
authors.affiliation: Hôpital de Rangueil, 1, avenue du Professeur-Jean-Poulhès, TSA 50032, 31059 Toulouse, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lubrano
authors.affiliation: Cabinet médical, 3, rue Saint-Sigisbert, 57050Le Ban-Saint-Martin, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Siegrist
authors.affiliation: Cabinet médical, 59, rue de la Providence, 31500 Toulouse, France.
authors.forename: Marie-Ève
authors.initials: MÈ
authors.lastname: Rougé-Bugat
authors.affiliation: Institut national du cancer, 52, avenue André-Morizet, 92513 Boulogne-Billancourt, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Mazeau-Woynar
authors.affiliation: Institut national du cancer, 52, avenue André-Morizet, 92513 Boulogne-Billancourt, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Verdoni
authors.affiliation: Institut national du cancer, 52, avenue André-Morizet, 92513 Boulogne-Billancourt, France.
authors.forename: François
authors.initials: F
authors.lastname: Planchamp
authors.affiliation: Hôpital Michallon, 38043 Grenoble, France.
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Leccia
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy; D004067:Digestive System Neoplasms; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008545:Melanoma / Q000556:secondary* / Q000628:therapy*; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy; D000096142:Cutaneous Malignant Melanoma
keywords: clinical practice guidelines; loco-regional treatments; metastatic cutaneous melanoma