title: Benign and malignant renal cells are differentially inhibited during prolonged organ preservation.
abstract: The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.
authors.affiliation: Urology Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Nengwang
authors.initials: N
authors.lastname: Yu
authors.affiliation: Department of Thoracic Medical Oncology, Beijing Cancer Hospital, Beijing, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Fu
authors.forename: Yubao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Urology Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Yibao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Orthopedics Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Zhihou
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Blood Purification Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Meng
authors.affiliation: Urology Department, Qilu Hospital, Jinan, Shandong, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Oncology Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Baocheng
authors.initials: B
authors.lastname: Wang
authors.affiliation: Urology Department, General Hospital of Jinan Military Command, Jinan, Shandong, China.
authors.forename: Aimin
authors.initials: A
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009392:Nephrectomy; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D009928:Organ Specificity; D014019:Tissue Donors
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen; D019188:Organ Preservation Solutions