title: Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat.
abstract: OBJECTIVE
  To investigate whether bone marrow mesenchymal stem cell (BMSC) treatment could improve the regeneration of endometrium and improve the endometrial receptivity in an experimental model of thin endometrium.
  
  
  METHODS
  Randomized, control trial, animal research.
  
  
  METHODS
  National key laboratory.
  
  
  METHODS
  Sprague-Dawley rats.
  
  
  METHODS
  Bone marrow mesenchymal stem cell transplantation by tail vein IV injection.
  
  
  METHODS
  Endometrial thickness, the expression of mark proteins for endometrial cell, and endometrial receptivity.
  
  
  RESULTS
  The endometrium was significantly thicker and the expression of cytokeratin, vimentin, integrin αγβ3, and leukemia inhibitor factor were significantly stronger compared with the control group. Some proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) messenger RNA (mRNA) and interleukin-1β mRNA, were significantly down-regulated, and anti-inflammatory cytokines, such as fibroblast growth factor-β (bFGF) mRNA and interleukin-6 mRNA, were significantly up-regulated in the experimental group compared with the control group.
  
  
  CONCLUSIONS
  The BMSCs have beneficial effect on thin endometrium, and may play a role through migration and immunomodulatory of BMSCs.
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Qiong
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Wang
authors.initials: W
authors.lastname: Yonggang
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Electronic address: zhaojing19840427@sina.com.
authors.forename: Li
authors.initials: L
authors.lastname: Yanping
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D004717:Endometrium / Q000473:pathology* / Q000502:physiology* / Q000601:surgery; D005260:Female; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*
keywords: Bone marrow mesenchymal stem cells (BMSCs); endometrial receptivity; immunodulatory; thin endometrium