title: Maternal serum AGEs levels in pregnancies associated with neural tube defects.
abstract: Advanced glycation end products (AGEs) plays an important role in diabetic embryopathy. AGE-mediated DNA damage could be a significant factor in the teratogenicity. The aim of the present study was to evaluate the association between the AGEs level and neural tube defects (NTDs) occurrence risk. Forty-eight mothers with NTD-affected pregnancies and 50 normal mothers were selected in this study. Blood were collected from the mothers and were assayed for serum AGEs, malondiadehyde (MDA) and hemoglobin A1c (HbA1c). Data were analyzed by logistic regression method. The study indicated that there were significant but modest lower prevalence for cases mothers on age, BMI and glucose levels compared with controls. NTD-affected mothers were significantly more likely to have higher AGEs levels (5.6±0.48 AU vs. 4.6±0.68 AU ρ<0.01) than controls. The AGEs levels were not correlated with MDA and HbA1c in NTDs mothers (r(2)=0.0006 p=0.8691 and r(2)=0.001 p=0.8172, respectively). The conclusion is that AGEs might be associated with NTDs occurrence.
authors.affiliation: Laboratory for Development, College of Life Sciences, Northwest University, Taibai west road 229#, Shaanxi, Xi'an 710068, People's Republic of China; National Engineering Research Center for Miniaturized Detection System, Northwest University, Shaanxi, Xi'an 710069, People's Republic of China. Electronic address: rulinli@nwu.edu.cn.
authors.forename: Rulin
authors.initials: R
authors.lastname: Li
authors.affiliation: Laboratory for Development, College of Life Sciences, Northwest University, Taibai west road 229#, Shaanxi, Xi'an 710068, People's Republic of China.
authors.forename: Peiyao
authors.initials: P
authors.lastname: Yang
authors.affiliation: College of Pharmaceutical sciences, Chongqing Medical University, Chongqing 401331, People's Republic of China.
authors.forename: Xuyang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Panyu central Hospital, Guang Zhou 511400, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009035:Mothers; D009436:Neural Tube Defects / Q000097:blood* / Q000209:etiology; D011247:Pregnancy / Q000097:blood; D011897:Random Allocation; D012189:Retrospective Studies
chemical_list: D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D008315:Malondialdehyde; C517652:hemoglobin A1c protein, human
keywords: Advanced glycated end products; HbA1c; Malondiadehyde; Neural tube defect; Oxidative stress