title: [Occurrence and molecular pathology of low grade gliomas].
abstract: BACKGROUND
  The WHO grade I. and II. low-grade gliomas represent nearly the 15% of all primary brain tumors. These tumours contain clinically, histologically and molecularly distinct tumor types. According to their histologic characteristic, grade II glial tumours are the diffuse astrocytoma, oligodendroglioma and oligoastrocytoma subgroups; ependymal tumors are not included in this study.
  
  
  METHODS
  In our publication, we analysed the histologically diagnosed glioma cases between 2007 and 2011 at our institution.
  
  
  RESULTS
  Low-grade gliomas were diagnosed in 127 cases (62 male / 65 female), and the mean ages were 39 years (+/- 20.3). More than half of the cancers were localized in the frontal lobe, and the second most frequent area was the temporal lobe. Finally, we complete our report with an overview of major molecular pathways in low-grade gliomas.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Neuropatológiai Tanszék, Debrecen.
authors.forename: Balázs
authors.initials: B
authors.lastname: Murnyák
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Neuropatológiai Tanszék, Debrecen.
authors.forename: Tamás
authors.initials: T
authors.lastname: Csonka
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Idegsebészeti Klinika, Debrecen.
authors.forename: Almos
authors.initials: A
authors.lastname: Klekner
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Neuropatológiai Tanszék, Debrecen.
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001254:Astrocytoma / Q000453:epidemiology / Q000473:pathology; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology*; D020732:Cytogenetic Analysis; D005260:Female; D017353:Gene Deletion; D005910:Glioma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D060787:Neoplasm Grading; D009837:Oligodendroglioma / Q000453:epidemiology / Q000473:pathology; D012737:Sex Factors