title: Concordance Between Prostate Needle Biopsy and Surgical Histopathology in a Primarily African-American Population.
abstract: BACKGROUND
  Prior studies have revealed that the concordance between biopsy and surgical specimens has been improving over time. However, to date, this has not been analyzed in an African American population, for whom data have often shown more aggressive prostate cancer than for other races.
  
  
  METHODS
  We analyzed 250 patients who were operated on at the NY Harbor Department of Veterans Affairs for localized prostate cancer between 2003 and 2010. The clinical biopsy scores were compared with the pathological biopsy scores. We compared the concordance using the κ coefficient. Univariate and multivariate logistic regressions were used to identify predictors for poor concordance.
  
  
  RESULTS
  This population consisted of 59.6% African Americans, 32% Caucasians, and 8.4% Hispanics. Overall, there was a 50% exact concordance between the biopsy and surgical specimens. The κ was 0.33, indicating fair agreement. Patients with a Gleason score of 6 were found to have an exact concordance 66% of the time, and those with a score of Gleason 7 (3 + 4) had an exact concordance 50% of the time. On univariate and multivariate analyses, only an increasing prostate-specific antigen was associated with reduced concordance. Race was not a significant predictor.
  
  
  CONCLUSIONS
  These data are in line with prior studies of concordance. Despite being a population with more aggressive prostate cancer, there does not appear to be an increase in the risk of discordance in African American men.
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Manuj
authors.initials: M
authors.lastname: Agarwal
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Schwartz
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Weiss
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Shan-Chin
authors.initials: SC
authors.lastname: Chen
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Arpit
authors.initials: A
authors.lastname: Chhabra
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Marvin
authors.initials: M
authors.lastname: Rotman
authors.affiliation: New York Harbor Healthcare System, Brooklyn, NY, USA SUNY Downstate Medical Center, Brooklyn, NY, USA David.schreiber@va.gov.
authors.forename: David
authors.initials: D
authors.lastname: Schreiber
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology* / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D014481:United States
keywords: concordance; prostate biopsy; radical prostatectomy