title: The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells.
abstract: Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Molnarfi
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Mahdia
authors.initials: M
authors.lastname: Benkhoucha
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland.
authors.forename: Catherine
authors.initials: C
authors.lastname: Juillard
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Kristbjörg
authors.initials: K
authors.lastname: Bjarnadóttir
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland; Department of Genetics and Laboratory Medicine, Laboratory Medicine Service, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland. Electronic address: Patrice.Lalive@hcuge.ch.
authors.forename: Patrice H
authors.initials: PH
authors.lastname: Lalive
mesh_terms: D000328:Adult; D000368:Aged; D060890:B7-H1 Antigen / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects*; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D055815:Young Adult
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; D016207:Cytokines; D006684:HLA-DR Antigens; D017228:Hepatocyte Growth Factor
keywords: Hepatocyte growth factor; Immune regulation; Monocyte-derived dendritic cells; Multiple sclerosis (MS); Neuroinflammation