title: Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane.
abstract: Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. volker.mailaender@mpip-mainz.mpg.de.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hofmann
authors.forename: Claudia
authors.initials: C
authors.lastname: Messerschmidt
authors.forename: Markus B
authors.initials: MB
authors.lastname: Bannwarth
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
authors.forename: Volker
authors.initials: V
authors.lastname: Mailänder
mesh_terms: D002462:Cell Membrane / Q000737:chemistry*; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019169:Jurkat Cells; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010569:Perylene / Q000031:analogs & derivatives / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; C550426:N-(2,6-diisopropylphenyl)perylene-3,4-dicarboximine; D011091:Polyesters; D011108:Polymers; C000499:ferric oxide; D019344:Lactic Acid; C033616:poly(lactide); D010569:Perylene