title: Serum ischemia-modified albumin levels at diagnosis and during treatment of late-onset neonatal sepsis.
abstract: Sepsis is one of the most common infectious conditions in the neonatal period, and continues as a major source of morbidity and mortality. The aim of this study is to determine serum ischemia-modified albumin (IMA) levels in late-onset neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow-up. Also, it is aimed to compare serum IMA levels with serum C-reactive protein (CRP), procalcitonin (PCT) levels and white blood cell count. The study was performed on 33 premature babies with sepsis and 21 healthy premature controls at 7-28 days of age. In the sepsis group, biochemical parameters and blood culture samples were obtained from the blood at the onset and on the fifth day of treatment for each patient. Serum IMA, CRP, PCT and white blood cell count were significantly higher in the sepsis group before treatment when compared with the control group. In addition, the levels of IMA were positively correlated with white blood cell count, CRP and PCT in the sepsis group before treatment. In conclusion, serum IMA levels may be useful in late-onset neonatal sepsis at the time of diagnosis and after therapy. As far as we know this is the first report about the assesment of illness diagnosis and after therapy using serum IMA levels, and further studies are needed to confirm our results in larger groups of patients.
authors.affiliation: Department of Biochemistry, Meram Medical Faculty, Necmettin Erbakan University , Konya , Turkey .
authors.forename: F Hümeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.forename: Idris
authors.initials: I
authors.lastname: Mehmetoglu
authors.forename: Ali
authors.initials: A
authors.lastname: Annagur
authors.forename: Huseyin
authors.initials: H
authors.lastname: Altunhan
authors.forename: Ekrem
authors.initials: E
authors.lastname: Erbay
authors.forename: Rahmi
authors.initials: R
authors.lastname: Ors
mesh_terms: D017668:Age of Onset; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D007234:Infant, Premature / Q000097:blood; D007235:Infant, Premature, Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D007958:Leukocyte Count; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000151:congenital / Q000175:diagnosis / Q000628:therapy; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human
keywords: C-reactive protein; ischemia-modified albumin; late-onset neonatal sepsis; procalcitonin; white blood cell count