title: The kinin B1 receptor mediates alloknesis in a murine model of inflammation.
abstract: Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice.
authors.affiliation: Postgraduate Institute, Southern Medical University, Guangzhou, China; Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
authors.forename: Jumian
authors.initials: J
authors.lastname: Feng
authors.affiliation: Postgraduate Institute, Southern Medical University, Guangzhou, China; Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
authors.forename: Yuanzhen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Postgraduate Institute, Southern Medical University, Guangzhou, China; Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
authors.forename: Jialing
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address: lijessy@msn.com.
authors.forename: Jiexian
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address: jiwenjin@msn.com.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Ji
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D065169:Bradykinin B1 Receptor Antagonists; D065094:Bradykinin B2 Receptor Antagonists; D003872:Dermatitis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D005620:Freund's Adjuvant; D008297:Male; D008810:Mice, Inbred C57BL; D010812:Physical Stimulation; D011537:Pruritus / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D043783:Receptor, Bradykinin B1 / Q000378:metabolism*; D043782:Receptor, Bradykinin B2 / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors; D012867:Skin / Q000378:metabolism*; D014110:Touch
chemical_list: D065169:Bradykinin B1 Receptor Antagonists; D065094:Bradykinin B2 Receptor Antagonists; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D017450:Receptors, Opioid, mu; D005620:Freund's Adjuvant; D001920:Bradykinin
keywords: Alloknesis; Complete Freund's adjuvant; Inflammation; Itch; Kinin B(1) receptor