title: Resveratrol induced structural and biochemical alterations in the tegument of Raillietina echinobothrida.
abstract: The root tuber of Carex species has been used as an anthelmintic medicine for intestinal helminthic infections in the Northeast region of India. The main compound present in the root tuber of the genus Carex is resveratrol. Therefore, the present study was conducted to evaluate the anthelmintic effects of resveratrol in Raillietina echinobothrida by using motility observation, electron microscopy, histochemical and biochemical analysis. Resveratrol causes complete inactivation and flaccid paralysis of the cestode, followed by death. The treated parasites also exhibited extensive distortion of the surface fine topography and decrease in the activities of major tegumental enzymes compared to that of control parasite. Ultrastructural alterations include changes in cell organelles present in the tegument and sub-tegumental cyton. Extensive alterations in the surface topography of the treated parasites resulted in a decrease in the activities of tegumental enzyme which suggest that, resveratrol may be useful as a therapeutic agent to treat cestode parasites.
authors.affiliation: Parasitology Laboratory, Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India.
authors.forename: Bikash Ranjan
authors.initials: BR
authors.lastname: Giri
authors.affiliation: Parasitology Laboratory, Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India. Electronic address: bishnuroy9@gmail.com.
authors.forename: Bishnupada
authors.initials: B
authors.lastname: Roy
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002589:Cestoda / Q000187:drug effects* / Q000648:ultrastructure; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D004791:Enzyme Inhibitors; D013267:Stilbenes; D000077185:Resveratrol
keywords: Raillietina echinobothrida; Resveratrol; Tegumental enzymes; Ultrastructure