title: Cyclodextrin containing biodegradable particles: from preparation to drug delivery applications.
abstract: Cyclodextrins (CDs) offer a very broad spectrum of applications in diverse fields of drug delivery. They are a family of cyclic α-(1-4)-linked oligosaccharides of α-d-glucopyranose subunits forming a more hydrophobic central cavity and a hydrophilic outer shell. CDs bear cage like supramolecular structures, similar to calixarenes, cyclophanes and crown ethers. No covalent bonds are required to host a guest molecule in the central cavity. The aim of this review is to throw light on some of the applications and formulation techniques for the novel multifunctional CD based nanocarriers used in diverse areas of drug delivery. Furthermore, this article highlights the molecular structure, chemical, complexation properties and the use of CDs in nanosystems like liposomes, magnetic nanoparticles, biodegradable polymers, micro and nanospheres and capsules.
authors.affiliation: University of Lyon, F-69622, Lyon, University Lyon-1, CNRS, UMR 5007, LAGEP-CPE, 43 bd 11 Novembre 1918, F-69622 Villeurbanne, France.
authors.forename: Nadiah
authors.initials: N
authors.lastname: Zafar
authors.affiliation: University of Lyon, F-69622, Lyon, University Lyon-1, CNRS, UMR 5007, LAGEP-CPE, 43 bd 11 Novembre 1918, F-69622 Villeurbanne, France.
authors.forename: Hatem
authors.initials: H
authors.lastname: Fessi
authors.affiliation: University of Lyon, F-69622, Lyon, University Lyon-1, CNRS, UMR 5007, LAGEP-CPE, 43 bd 11 Novembre 1918, F-69622 Villeurbanne, France. Electronic address: elaissari@lagep.univ-lyon1.fr.
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Elaissari
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes; D008863:Microspheres; D053758:Nanoparticles; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D008081:Liposomes; D011108:Polymers
keywords: Biodegradable particles; Cyclodextrins; Drug delivery; Encapsulation; Molecular cages; Release