title: The ethanol extract of Zingiber zerumbet Smith attenuates non-alcoholic fatty liver disease in hamsters fed on high-fat diet.
abstract: The beneficial effects of the ethanol extract of Zingiber zerumbet rhizome (EEZZR) for use in the treatment of non-alcoholic fatty liver disease (NAFLD) were investigated. Syrian golden hamsters were fed a high-fat diet to induce NAFLD. EEZZR (100, 200, or 300mg/kg) were orally administered by gavage once daily for 8weeks. The higher plasma levels of total cholesterol, triglycerides, free fatty acids, and hepatic lipids, as well as the degree of insulin resistance were lowered by EEZZR. Histological evaluation of liver specimens demonstrated that the hepatic steatosis of EEZZR-treated groups was improved. EEZZR decreased hepatic mRNA levels of sterol regulatory element-binding protein-1c and its lipogenic target genes. The hepatic mRNA expression of peroxisome proliferator-activated receptor α, together with its target genes responsible for β-oxidation of fatty acids were also upregulated by EEZZR. In conclusion, these findings suggest that EEZZR has the promising potential to ameliorate NAFLD.
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC.
authors.forename: Chia Ju
authors.initials: CJ
authors.lastname: Chang
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC.
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC.
authors.forename: Thing-Fong
authors.initials: TF
authors.lastname: Tzeng
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC. Electronic address: iml@tajen.edu.tw.
authors.forename: I-Min
authors.initials: IM
authors.lastname: Liu
mesh_terms: D000818:Animals; D001483:Base Sequence; D006224:Cricetinae; D016207:Cytokines / Q000097:blood; D017931:DNA Primers; D059305:Diet, High-Fat; D000431:Ethanol / Q000737:chemistry; D005234:Fatty Liver / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D065626:Non-alcoholic Fatty Liver Disease; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D016207:Cytokines; D017931:DNA Primers; D018836:Inflammation Mediators; D007328:Insulin; D010936:Plant Extracts; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D000431:Ethanol
keywords: High-fat diet; Non-alcoholic fatty liver disease; Peroxisome proliferator-activated receptor α; Sterol regulatory element-binding protein-1c; Zingiber zerumbet rhizome