title: Successful surgical treatment for pulmonary crystal-storing histiocytosis following the onset of gastric non-hodgkin lymphoma.
abstract: Crystal-storing histiocytosis is a rare clinical entity characterized by an increase in the number of abnormal histiocytes accompanied by accumulation of crystallized immunoglobulins. We describe the case of an 80-year-old man who presented with crystal-storing histiocytosis of the lung 13 years after receiving a diagnosis of gastric non-Hodgkin lymphoma (NHL ; clinical stage, Lugano IA). After wedge resection of the left upper lobe, the histological findings showed crystal-storing histiocytosis with CD68(+), some small to medium lymphoid cells with CD79a(+) with κ(+(weekly)) and λ(-), and some plasma cells with CD138(+), and rearrangement of the immunoglobulin heavy chain. Based on the nonrecurrent gastric NHL, small B-cell population, and failure to detect the same clone by polymerase chain reaction analysis, our case was classified as pulmonary localized crystal-storing histiocytosis without underlying lymphoproliferative or plasma cell disorder. The findings of minor B-cell populations harboring a heavy chain rearrangement with slight light-chain restriction (κ > λ) may be related to the pathogenesis of crystallogenesis and crystal-storing histiocytosis. Moreover, surgical treatment may be an effective therapeutic option for solitary crystal-storing histiocytosis.
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kawano
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Beppu
authors.forename: Mayumi
authors.initials: M
authors.lastname: Oyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Himeji
authors.forename: Shuro
authors.initials: S
authors.lastname: Yoshida
authors.forename: Takuro
authors.initials: T
authors.lastname: Kuriyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Masuyama
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Shimao
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ueda
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
mesh_terms: D000369:Aged, 80 and over; D019788:Fluorodeoxyglucose F18; D015321:Gene Rearrangement; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D015614:Histiocytosis / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007136:Immunoglobulins / Q000737:chemistry / Q000378:metabolism; D007150:Immunohistochemistry; D008168:Lung / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis; D008297:Male; D049268:Positron-Emission Tomography; D003074:Solitary Pulmonary Nodule / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D007143:Immunoglobulin Heavy Chains; D007136:Immunoglobulins; D019788:Fluorodeoxyglucose F18