title: Accumulation of fascin+ cells during experimental autoimmune neuritis.
abstract: BACKGROUND
  Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles.
  
  
  METHODS
  Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats.
  
  
  RESULTS
  A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN.
  
  
  CONCLUSIONS
  Our results suggest a pathological role of Fascin in EAN.
  The virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811.
authors.forename: Zichen
authors.initials: Z
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Bangwei
authors.initials: B
authors.lastname: Lou
authors.forename: Jian
authors.initials: J
authors.lastname: Xiong
authors.forename: Hermann J
authors.initials: HJ
authors.lastname: Schluesener
authors.affiliation: Institute of Immunology, Third Military Medical University of PLA, 30 Gaotanyan Main Street, Chongqing 400038, People's Republic of China. zhangzhiren@yahoo.com.
authors.forename: Zhiren
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D020275:Guillain-Barre Syndrome / Q000378:metabolism; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D009444:Neuritis, Autoimmune, Experimental / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin