title: Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra.
abstract: A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Ksenya M
authors.initials: KM
authors.lastname: Tabakmakher
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Alla G
authors.initials: AG
authors.lastname: Guzii
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
authors.affiliation: Korea Institute of Ocean Science & Technology, Marine Natural Products Laboratory, Ansan 426-744, Republic of Korea.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia.
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012426:Russia
chemical_list: D000970:Antineoplastic Agents; C585942:monanchomycalin C; D019791:Guanidine