title: Icodextrin-based continuous ambulatory peritoneal dialysis therapy effectively reduces left ventricular mass index and protects cardiac function in patients with end-stage renal disease.
abstract: Increased left ventricular mass index (LVMI) is commonly observed in patients undergoing peritoneal dialysis (PD). The present study aimed to determine the effect of icodextrin (Ico) on LVMI in PD patients with maintained residual renal function (RRF). This retrospective study included 18 patients (12 men, 6 women; average age: 62 +/- 10 years) diagnosed with indications for PD therapy and divided into two groups: those treated with Ico (Ico group) and without Ico (non-Ico group). Echocardiography was performed at the beginning of continuous ambulatory PD and after 6 and 12 months. A significant reduction in LVMI (p < 0.01) and an increase in ultrafiltration (p < 0.01) were observed after 6 months of lco treatment and were maintained for 12 months. Ejection fraction was significantly lower in the non-Ico group after 12 months (p < 0.01), but was not altered in the Ico group. Blood pressure, cardiothoracic ratio, urine volume, and N-terminal prohormone of brain natriuretic peptide were unaffected by PD treatment up to 12 months. The year-averaged ultrafiltration and the reduction in LVMI were significantly correlated (p < 0.05). Ico effectively improved LVMI and maintained ejection fraction in end-stage renal disease patients within 1 year from PD initiation. Notably, treatment with Ico resulted in a reduction of LVMI (associated with increased ultrafiltration), with no significant reduction in RRF.
authors.affiliation: Division of Nephrology, Kokura Memorial Hospital, Kitakyushu, Japan. iku-ohba@med.tohoku.ac.jp
authors.forename: Ikuko
authors.initials: I
authors.lastname: Oba
authors.affiliation: Division of Nephrology, Kyushu Koseinenkin Hospital, Kitakyushu, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Shinozaki
authors.affiliation: Division of Nephrology, Kokura Memorial Hospital, Kitakyushu, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Harada
authors.affiliation: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Division of Nephrology, Kokura Memorial Hospital, Kitakyushu, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kanai
mesh_terms: D000368:Aged; D005260:Female; D005936:Glucans / Q000627:therapeutic use; D005947:Glucose / Q000627:therapeutic use; D015312:Hemodialysis Solutions / Q000627:therapeutic use; D006801:Humans; D000077607:Icodextrin; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D012189:Retrospective Studies; D014462:Ultrafiltration; D016277:Ventricular Function, Left
chemical_list: D005936:Glucans; D015312:Hemodialysis Solutions; D000077607:Icodextrin; D005947:Glucose