title: Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft.
abstract: Although there are many studies that focus on understanding the consequence of pumping mode (continuous vs. pulsatile) associated with ventricular assist devices (VADs) on pediatric vascular pulsatility, the impact on local hemodynamics has been largely ignored. Hence, we compare not only the hemodynamic parameters indicative of pulsatility but also the local flow fields in the aorta and the great vessels originating from the aortic arch. A physiologic graft anastomotic model is constructed based on a pediatric, patient specific, aorta with a graft attached on the ascending aorta. The flow is simulated using a previously validated second-order accurate Navier-Stokes flow solver based upon a finite volume approach. The major findings are: (1) pulsatile support provides a greater degree of vascular pulsatility when compared to continuous support, which, however, is still 20% less than pulsatility in the healthy aorta; (2) pulsatile support increases the flow in the great vessels, while continuous support decreases it; (3) complete VAD support results in turbulence in the aorta, with maximum principal Reynolds stresses for pulsatile support and continuous support of 7081 and 249 dyn/cm2, respectively; (4) complete pulsatile support results in a significant increase in predicted hemolysis in the aorta; and (5) pulsatile support causes both higher time-averaged wall shear stresses (WSS) and oscillatory shear indices (OSI) in the aorta than does continuous support. These findings will help to identify the risk of graft failure for pediatric patients with pulsatile and continuous VADs.
authors.affiliation: Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA ; The Applied Research Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Deutsch
authors.affiliation: The Applied Research Laboratory, The Pennsylvania State University, University Park, PA 16802, USA ; Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Paterson
authors.affiliation: Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Keefe B
authors.initials: KB
authors.lastname: Manning
keywords: Anastomosis; Hemolysis; Oscillatory shear index; Reynolds stress; Wall shear stress