title: Necrolytic acral erythema.
abstract: Necrolytic acral erythema is a rare, cutaneous manifestation of hepatitis C virus infection that is characterized by erythematous, violaceous or dusky papules, blisters, and/or erosions in the early stages and by well-demarcated, hyperkeratotic, targetoid plaques with a peripheral rim of macular erythema, secondary lichenification and hyperpigmentation, and overlying fine micaceous or necrotic-appearing scale in the later stages. Because most topical modalities prove ineffective, treatment of the underlying viral infection or therapeutic zinc supplementation are required for clinical improvement.
authors.affiliation: New York University School of Medicine.
authors.forename: John Montgomery
authors.initials: JM
authors.lastname: Yost
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Boyd
authors.forename: Rishi R
authors.initials: RR
authors.lastname: Patel
authors.forename: Sarika
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Franks
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004890:Erythema / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005528:Foot / Q000473:pathology; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D015032:Zinc / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D015032:Zinc