title: Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation.
abstract: In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon-fluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Our approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of -CFH2, -CF2H, -C n F2 n +1 and -SCF3 groups onto sp² carbon atoms. Transformations are discussed according to the reaction-type and the metal employed. The review will not extend to conventional non-transition metal methods to these fluorinated groups.
authors.affiliation: CNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Landelle
authors.affiliation: CNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France.
authors.forename: Armen
authors.initials: A
authors.lastname: Panossian
authors.affiliation: Bayer CropScience AG, Alfred-Nobel-Strasse 50, 40789 Monheim, Germany.
authors.forename: Sergiy
authors.initials: S
authors.lastname: Pazenok
authors.affiliation: Bayer SAS, 14 impasse Pierre Baizet, 69263 Lyon, Cedex 09, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.affiliation: CNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France.
authors.forename: Frédéric R
authors.initials: FR
authors.lastname: Leroux
keywords: catalysis; cross-coupling; difluoromethylation; fluorine; monofluoromethylation; organo-fluorine; transition metal; trifluoromethylation; trifluoromethylthiolation