title: Response selection impairment in schizophrenia transcends sensory and motor modalities.
abstract: Response selection dysfunction contributes to processing speed impairment in schizophrenia. However, it is unclear if response selection impairment transcends sensory and motor modalities or is modality specific. To address this question, healthy subjects and individuals with schizophrenia completed reaction time (RT) experiments with different combinations of sensory cues (i.e. visual, auditory) and motor response (i.e. manual, vocal). We found that response selection impairment in schizophrenia was present regardless of the sensory and motor modality of the tasks and correlated with performance on neuropsychological tests of processing speed. These results implicate dysfunction of amodal response selection brain regions in schizophrenia. Interventions that reduce the length of response selection stage processing may improve processing speed in schizophrenia.
authors.affiliation: Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Woodward
authors.affiliation: Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Brittney
authors.initials: B
authors.lastname: Duffy
authors.affiliation: Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Haleh
authors.initials: H
authors.lastname: Karbasforoushan
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D002755:Choice Behavior / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology*; D003463:Cues; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Motor; Processing speed; Response selection; Schizophrenia; Sensory