title: Relationship between serum leptin level and disease activity in patients with systemic sclerosis.
abstract: To determine the relationship between serum leptin levels and disease activity in systemic sclerosis (SSc). A total of 60 subjects (30 controls and 30 patients) were included. The inflammatory markers and leptin levels were evaluated and body mass index (BMI) was measured for both groups. The assessment of the skin involvement was performed based on the modified Rodnan skin score (mRSS). Disease activity was evaluated according to the Valentini scleroderma disease activity index. There was a significant difference between the patient and control groups in terms of BMI (p < 0.05); however there was no difference with regards to age and gender (p > 0.05). Valentini scores and mRSS were determined to be significantly higher in active patients (n = 14) than in inactive patients (n = 16) (p < 0.05). No significant difference was determined between groups in terms of leptin levels (p > 0.05). However, leptin levels were significantly lower in active patients than in inactive patients (p < 0.05). We found a significant positive correlation between serum leptin and BMI (p < 0.05), and leptin and serum C3 levels (p < 0.05); no relationship was detected between leptin and other parameters. Leptin can be used as an activity marker in SSc. Further studies, including larger series, should be carried out to clarify this relationship.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Budulgan
authors.forename: Banu
authors.initials: B
authors.lastname: Dilek
authors.forename: Şevin Buluttekin
authors.initials: ŞB
authors.lastname: Dağ
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Batmaz
authors.forename: İsmail
authors.initials: İ
authors.lastname: Yıldız
authors.forename: Mustafa Akif
authors.initials: MA
authors.lastname: Sarıyıldız
authors.forename: Remzi
authors.initials: R
authors.lastname: Çevik
authors.forename: Kemal
authors.initials: K
authors.lastname: Nas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D020738:Leptin