title: Beneficial Effect of 7-O-Galloyl-D-sedoheptulose, a Polyphenol Isolated from Corni Fructus, against Diabetes-Induced Alterations in Kidney and Adipose Tissue of Type 2 Diabetic db/db Mice.
abstract: Traditional medicines are being focused on as possible treatments for diabetes and its complications because of their negligible toxic and/or side effects. In line with this, our group has reported that Corni Fructus, a traditional medicine considered exhibiting beneficial effects on liver and kidney functions, possessed an antidiabetic effect via ameliorating glucose-mediated metabolic disorders. To add to these findings, we screened the iridoid glycoside fraction containing morroniside and loganin, and low molecular weight polyphenol fraction containing 7-O-galloyl-d-sedoheptulose (GS) from Corni Fructus. To our knowledge, GS is a compound only detected in Corni Fructus, and its biological activity has been poorly understood until now. For these reasons, we examined whether GS has an ameliorative effect on diabetic changes using type 2 diabetic db/db mice. Our findings suggest that GS has a beneficial effect on the pathological state of the serum, kidney, and adipose tissue related to diabetic damage.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Chan Hum
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Food Science & Nutrition, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Jeong Sook
authors.initials: JS
authors.lastname: Noh
authors.affiliation: Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Republic of Korea.
authors.forename: Jong Cheol
authors.initials: JC
authors.lastname: Park
authors.affiliation: Graduate School of Science and Engineering for Research, University of Toyama, Toyama 930-8555, Japan ; Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa