title: [Latest development in mass spectrometry for clinical application].
abstract: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in special clinical chemistry laboratories. It significantly increases the analytic potential in clinical chemistry, especially in the field of low molecular weight biomarker analysis. This review summarizes the state of the art in mass spectrometry and related techniques for clinical application with a main focus on recent developments in LC-MS. Current trends in ionization techniques, automated online sample preparation techniques coupled with LC-MS, and ion mobility spectrometry are discussed. Emerging mass spectrometric approaches complementary to LC-MS are discussed as well.
authors.affiliation: Agilent Technologies Japan, Ltd. Hachioji 192-8510, Japan. masahiko_takino@agilent.com
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takino
mesh_terms: D001331:Automation / Q000379:methods; D002624:Chemistry, Clinical / Q000379:methods; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D008970:Molecular Weight
chemical_list: D007477:Ions