title: Synthesis and characterization of novel polymer-drug conjugates based on the poly(styrene-alt-maleic anhydride) as a potential method for drug release.
abstract: Six well known drugs, captopril, metformin-HCl, metroniazole, nortriptyline-HCl, fluoxetine-HCl and betahistin-HCl, were grafted to poly(styrene-alt-maleic anhydride) (PSMA). Grafting was attained by combining of anhydride groups in the PSMA with therapeutic agents containing NH, OH or SH groups. The covalently grafted drugs were identified by infrared, (1)H NMR and UV-Vis spectroscopy. The drug release data at different times fits well to the Korsmeyer-Peppas equation. The analysis of the exponent n of this model revealed a dominant Fickian diffusion mechanism under the in vitro conditions. Furthermore, mean dissolution time values (45.9 to 86.7 h) indicate a high resistance against drugs transport, the highest being obtained for betahistin-HCL.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Khazaei
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Saednia
authors.forename: Javad
authors.initials: J
authors.lastname: Saien
authors.forename: Maryam Kiani
authors.initials: MK
authors.lastname: Borazjani
authors.forename: Sadegh
authors.initials: S
authors.lastname: Rahmati
authors.forename: Ali
authors.initials: A
authors.lastname: Hashempour-Zaviye
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Abbasi
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008298:Maleates / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry* / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004337:Drug Carriers; D008298:Maleates; D004364:Pharmaceutical Preparations; D011108:Polymers; D011137:Polystyrenes; C520889:poly(styrene-alt-maleic anhydride)