title: A new taraxerol derivative from the roots of Microcos tomentosa.
abstract: A new 3beta-O-vanilloyl-taraxerol, microcisin (1) and eight known compounds, 3beta-taraxerol acetate (2), 3beta-taraxerol (3), cholest-4-en-3-one (4), cholest-4-en-6beta-ol-3-one (5), beta-sitosterol (6), 7-hydroxycadalene (7), mellein (8) and vanillin (9), were isolated from the roots of Microcos tomentosa. The structures were determined by extensive analysis of their spectroscopic data. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cells.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sutin
authors.initials: S
authors.lastname: Kaennakam
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Jirapast
authors.initials: J
authors.lastname: Sichaem
authors.affiliation: Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand.
authors.forename: Suttira
authors.initials: S
authors.lastname: Khumkratok
authors.affiliation: Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029646:Tiliaceae / Q000737:chemistry*
chemical_list: C585936:3beta-O-vanilloyl-taraxerol; D009828:Oleanolic Acid; C005802:taraxerol