title: Question of an infectious etiology or contribution to the pathogenesis of infantile hypertrophic pyloric stenosis.
abstract: Infantile hypertrophic pyloric stenosis is a concerning cause of nonbilious vomiting in the neonatal population. Although a number of etiological theories exist, its exact cause remains nebulous. The question of an infectious etiology (or contribution) has been previously examined in case reports and case series, with recent support through suggestions of seasonality and familial aggregation with unclear inheritance patterns. The present review discusses the published literature regarding infectious etiologies of infantile hypertrophic pyloric stenosis. Furthermore, it attempts to demonstrate that newer research regarding an NOS1 genetic etiology does not exclude, but rather can be consistent with, an infectious etiology.
authors.affiliation: Department of Internal Medicine, Massachusetts General Hospital, Boston, MA.
authors.forename: Taher
authors.initials: T
authors.lastname: Modarressi
mesh_terms: D000818:Animals; D002177:Candidiasis / Q000150:complications; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000150:complications*; D008297:Male; D052248:Nitric Oxide Synthase Type I; D046248:Pyloric Stenosis, Hypertrophic / Q000453:epidemiology / Q000209:etiology*; D012621:Seasons; D012737:Sex Factors; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000150:complications; D014777:Virus Diseases / Q000150:complications
chemical_list: D052248:Nitric Oxide Synthase Type I