title: [Anorexia nervosa - from a neuroscience perspective].
abstract: Anorexia nervosa is a frequent disorder especially among adolescent girls and young women, with high morbidity, mortality, and relapse rates. To date, no single therapeutic approach has proved to be superior to others (Herpertz et al., 2011). It remains unclear how its etiology and pathology are encoded within cognitive, neural, and endocrinological processes that modulate important mechanisms in appetitive processing and weight regulation. Yet, several trait characteristics have been identified in AN which might reflect predisposing factors. Further, altered levels of neuropeptides and hormones that regulate appetite and feeding behavior have been found during both the acute and the recovered state, pointing to dysfunctional mechanisms in AN that persist even after malnutrition has ceased. Researchers are also hoping that brain imaging techniques will allow for a more detailed investigation of the neural basis of reward and punishment sensitivity that appears to be altered in AN. The integration and extension of recent findings in these areas will hopefully provide a more comprehensive understanding of the disorder and hence enable the development of more effective treatments.
authors.affiliation: Charité-Universitätsmedizin Berlin, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters.
authors.forename: Viola
authors.initials: V
authors.lastname: Kappel
authors.affiliation: Charité-Universitätsmedizin Berlin, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters.
authors.forename: Betteke
authors.initials: B
authors.lastname: van Noort
authors.affiliation: Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie.
authors.forename: Franziska
authors.initials: F
authors.lastname: Ritschel
authors.affiliation: Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie.
authors.forename: Maria
authors.initials: M
authors.lastname: Seidel
authors.affiliation: Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D001070:Appetitive Behavior / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D020738:Leptin / Q000502:physiology; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D018377:Neurotransmitter Agents / Q000502:physiology; D011502:Protein-Energy Malnutrition / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D060685:Sense of Coherence / Q000502:physiology; D015430:Weight Gain / Q000502:physiology; D055815:Young Adult
chemical_list: D020738:Leptin; D018377:Neurotransmitter Agents
keywords: Anorexia nervosa; Belohnungssystem; Endokrinologie; Neurobiologie; Neuropsychologie; anorexia nervosa; endocrinology; neurobiology; neuropsychology; reward system