title: Multi-level and multi-scale integrative approach to the understanding of human blastocyst implantation.
abstract: Implantation is a complex process which results in fixation of zona pellucida free blastocyst to the maternal uterine endometrium. In the human, it involves progesterone mediated preparation of endometrium, age- and stage-matched development of pre-implantation embryo, and interaction between embryo and endometrium. In the present essay, we present the case to explain why there is a necessity of undertaking multi-level, multi-scale integrative approach to deconstruct the succession process of endometrial development to the climax of implantation.
authors.affiliation: Department of Physiology, North DMC Medical College, Hindu Rao Hospital, Delhi 110007, India. Electronic address: jsen47@gmail.com.
authors.forename: Jayasree
authors.initials: J
authors.lastname: Sengupta
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: debabrata.ghosh1@gmail.com.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D010064:Embryo Implantation; D004622:Embryo, Mammalian / Q000196:embryology; D004626:Embryology / Q000379:methods*; D004717:Endometrium / Q000196:embryology; D005260:Female; D006801:Humans
keywords: Blastocyst; Endometrium; Implantation; Informational networks; Receptivity