title: Diffuse large B-cell lymphoma with mass lesions of skull vault and ileocecum.
abstract: We report a rare case of non-Hodgkin lymphoma with mass lesions of skull vault and ileocecum. The patient was an 82-year-old Japanese woman who exhibited a painless subcutaneous scalp tumor in the right parietal region associated with no neurological abnormalities. Magnetic resonance imaging of the head demonstrated a mass in the skull vault with iso- to hypointense signals on both T1- and T2-weighted imaging. Biopsy of the mass revealed that the tumor comprised large cells that were immunoreactive for CD20 (L-26) and CD79a. Diffuse large B-cell lymphoma (DLBCL) was therefore diagnosed. Further investigation could not identify any other evidence of systemic lymphoma other than ileocecal lesions. She was treated by irradiation (45 Gy) of the mass on the parietal bone and with rituximab, pirarubicin, cyclophosphamide, and vincristine. The patient achieved complete remission after 3 cycles of systemic chemotherapy. As of 30 months after presentation, no signs of lymphoma have been found.
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kosugi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kume
authors.forename: Joji
authors.initials: J
authors.lastname: Sato
authors.forename: Ikuo
authors.initials: I
authors.lastname: Sakuma
authors.forename: Junta
authors.initials: J
authors.lastname: Moroi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Izumi
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Sato
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Masatomo
authors.initials: M
authors.lastname: Takahashi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002432:Cecum / Q000473:pathology*; D020685:Colonoscopes; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology*; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D011878:Radiotherapy; D012886:Skull / Q000473:pathology*; D016896:Treatment Outcome