title: Postprandial thermogenesis and substrate oxidation are unaffected by sleep restriction.
abstract: OBJECTIVE
  The extent to which alterations in energy expenditure (EE) in response to sleep restriction contribute to the short sleep-obesity relationship is not clearly defined. Short sleep may induce changes in resting metabolic rate (RMR), thermic effect of food (TEF) and postprandial substrate oxidation.
  
  
  METHODS
  Ten females (age and body mass index: 22-43 years and 23.4-28 kg m(-2)) completed a randomized, crossover study assessing the effects of short (4 h per night) and habitual (8 h per night) sleep duration on fasting and postprandial RMR and respiratory quotient (RQ). Measurements were taken after three nights using whole-room indirect calorimetry. The TEF was assessed over a 6-h period following consumption of a high-fat liquid meal.
  
  
  RESULTS
  Short versus habitual sleep did not affect RMR (1.01±0.05 and 0.97±0.04 kcal min(-1); P=0.23). Fasting RQ was significantly lower after short versus habitual sleep (0.84±0.01 and 0.88±0.01; P=0.028). Postprandial EE (short: 1.13±0.04 and habitual: 1.10±0.04, P=0.09) and RQ (short: 0.88±0.01 and habitual: 0.88±0.01, P=0.50) after the high-fat meal were not different between conditions. TEF was similar between conditions (0.24±0.02 kcal min(-1) in both; P=0.98), as was the ~6-h incremental area under the curve (1.16±0.10 and 1.17±0.09 kcal min(-1) × 356 min after short and habitual sleep, respectively; P=0.92).
  
  
  CONCLUSIONS
  Current findings observed in non-obese healthy premenopausal women do not support the hypothesis that alterations in TEF and postprandial substrate oxidation are major contributors to the higher rate of obesity observed in short sleepers. In exploring a role of sleep duration on EE, research should focus on potential alterations in physical activity to explain the increased obesity risk in short sleepers.
authors.affiliation: New York Obesity Nutrition Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Shechter
authors.affiliation: New York Obesity Nutrition Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Rising
authors.affiliation: New York Obesity Nutrition Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Wolfe
authors.affiliation: New York Obesity Nutrition Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Albu
authors.affiliation: New York Obesity Nutrition Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
authors.forename: M-P
authors.initials: MP
authors.lastname: St-Onge
mesh_terms: D000328:Adult; D001481:Basal Metabolism; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D004734:Energy Metabolism; D005215:Fasting; D005260:Female; D006801:Humans; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D019518:Postprandial Period; D015203:Reproducibility of Results; D012890:Sleep; D012892:Sleep Deprivation / Q000378:metabolism / Q000503:physiopathology*; D022722:Thermogenesis
chemical_list: D004041:Dietary Fats