title: Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage.
abstract: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor. Numerous studies support the contribution of reactive oxygen and nitrogen species in the pathogenesis of hypertension, as well as other pathologies associated with ischemia/reperfusion. However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other biomarkers such as endothelial progenitor cells, endothelial microparticles, and ischemia modified albumin, is just emerging. Oxidative stress has been suggested as a pathogenic factor and therapeutic target in early stages of essential hypertension. Systolic and diastolic blood pressure correlated positively with plasma F2-isoprostane levels and negatively with total antioxidant capacity of plasma in hypertensive and normotensive patients. Cardiac surgery with extracorporeal circulation causes an ischemia/reperfusion event associated with increased lipid peroxidation and protein carbonylation, two biomarkers associated with oxidative damage of cardiac tissue. An enhancement of the antioxidant defense system should contribute to ameliorating functional and structural abnormalities derived from this metabolic impairment. However, data have to be validated with the analysis of the appropriate oxidative stress and/or nitrosative stress biomarkers.
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile.
authors.forename: Ramón
authors.initials: R
authors.lastname: Rodrigo
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile.
authors.forename: Matías
authors.initials: M
authors.lastname: Libuy
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Feliú
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hasson
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015227:Lipid Peroxidation; D017202:Myocardial Ischemia / Q000097:blood*; D015428:Myocardial Reperfusion Injury / Q000097:blood*; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000097:blood; D017382:Reactive Oxygen Species / Q000097:blood; D020257:Ventricular Remodeling
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species