title: [A propose to suspend the use of hydroxyethyl starch for fluid resuscitation in shock phase of severe burns].
abstract: Based on the result of randomized controlled trials and meta-analysis recently, the infusion of hydroxyethyl starch (HES) was not shown to over match routine crystalline solution in exerting resuscitation effect against hypovolemia of patients with burn shock, severe systematic infection, or other critical conditions, on the other hand, it may induce renal toxicity and other toxic and side effects. Since the pathological mechanism underlying hypovolemia during shock phase after burn is similar to that of severe systemic infection, we propose to suspend the use of HES for fluid resuscitation during the shock phase of severe burn until further elucidation.
authors.affiliation: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
authors.forename: Gao-xing
authors.initials: GX
authors.lastname: Luo
authors.affiliation: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
authors.forename: Yi-zhi
authors.initials: YZ
authors.lastname: Peng
authors.affiliation: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D002056:Burns / Q000628:therapy*; D000075202:Contraindications; D005440:Fluid Therapy; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D020896:Hypovolemia / Q000517:prevention & control*; D012151:Resuscitation; D012769:Shock / Q000628:therapy*
chemical_list: D006895:Hydroxyethyl Starch Derivatives