title: Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer.
abstract: Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (-1562C > T) promoter polymorphism with breast cancer invasion and progression. The study involves 200 breast cancer patients and age-matched 191 healthy controls. The SNP-1562C > T (rs3918242) in MMP-9 promoter region was examined by allele-specific polymerase chain reaction and gel electrophoresis. The genotypes were determined and compared between patients and controls, and the influence of the polymorphism on clinicopathological data was analyzed. The T allele of the -1562C > T MMP-9 polymorphism was detected more frequently in breast cancer patients than controls (p < 0.001). Our results suggest the clinical importance of MMP-9 gene polymorphism (-1562C > T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer.
authors.affiliation: Department of Genetics, Osmania University, Hyderabad, Andhra Pradesh, 500 007, India.
authors.forename: P
authors.initials: P
authors.lastname: Chiranjeevi
authors.forename: K Mrudula
authors.initials: KM
authors.lastname: Spurthi
authors.forename: N Santhoshi
authors.initials: NS
authors.lastname: Rani
authors.forename: G Rajesh
authors.initials: GR
authors.lastname: Kumar
authors.forename: T Mohini
authors.initials: TM
authors.lastname: Aiyengar
authors.forename: M
authors.initials: M
authors.lastname: Saraswati
authors.forename: G
authors.initials: G
authors.lastname: Srilatha
authors.forename: G Kishore
authors.initials: GK
authors.lastname: Kumar
authors.forename: Sudha
authors.initials: S
authors.lastname: Sinha
authors.forename: C Sanjeeva
authors.initials: CS
authors.lastname: Kumari
authors.forename: B Nagarjuna
authors.initials: BN
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Vishnupriya
authors.forename: H Surekha
authors.initials: HS
authors.lastname: Rani
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: D020780:Matrix Metalloproteinase 9