title: Association of omentin Val109Asp polymorphism with coronary artery disease.
abstract: OBJECTIVE
  Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causes of death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and is inversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigate the relationship between omentin Val109Asp polymorphism and CAD.
  
  
  METHODS
  This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography were included in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and compared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison of clinical characteristics according to the genotypes.
  
  
  RESULTS
  There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5 fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49).
  
  
  CONCLUSIONS
  Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to be more in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experiment should done with larger population to clarify this issue.
authors.affiliation: Department of Medical Biology and Genetics, Institute of Health Science, Faculty of Medicine, Düzce University, Düzce-Turkey. kursatyay@yahoo.com.
authors.forename: Umit
authors.initials: U
authors.lastname: Yörük
authors.forename: Kürşat Oğuz
authors.initials: KO
authors.lastname: Yaykaşli
authors.forename: Hakan
authors.initials: H
authors.lastname: Özhan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Memişoğullari
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karabacak
authors.forename: Serkan
authors.initials: S
authors.lastname: Bulur
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Aslantaş
authors.forename: Cengiz
authors.initials: C
authors.lastname: Başar
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Kaya
mesh_terms: D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics*; D016207:Cytokines / Q000097:blood / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D005838:Genotype; D006801:Humans; D037102:Lectins / Q000097:blood / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins