title: Fiber feature map based landmark initialization for highly deformable DTI registration.
abstract: This paper presents a novel pipeline for the registration of diffusion tensor images (DTI) with large pathological variations to normal controls based on the use of a novel feature map derived from white matter (WM) fiber tracts. The research presented aims towards an atlas based DTI analysis of subjects with considerable brain pathologies such as tumors or hydrocephalus. In this paper, we propose a novel feature map that is robust against variations in WM fiber tract integrity and use these feature maps to determine a landmark correspondence using a 3D point correspondence algorithm. This correspondence drives a deformation field computed using Gaussian radial basis functions(RBF). This field is employed as an initialization to a standard deformable registration method like demons. We present early preliminary results on the registration of a normal control dataset to a dataset with abnormally enlarged lateral ventricles affected by fatal demyelinating Krabbe disease. The results are analyzed based on a regional tensor matching criterion and a visual assessment of overlap of major WM fiber tracts. While further evaluation and improvements are necessary, the results presented in this paper highlight the potential of our method in handling registration of subjects with severe WM pathology.
authors.affiliation: Dept Pediatrics, University of Pittsburgh, PA, USA ; Dept Psychiatry, University of North Carolina, Chapel Hill, NC.
authors.forename: Aditya
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Harvard Medical School, Boston MA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Toews
authors.affiliation: Dept Computer Science, University of North Carolina, Chapel Hill, NC.
authors.forename: Ravikiran
authors.initials: R
authors.lastname: Janardhana
authors.affiliation: Harvard Medical School, Boston MA.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Rathi
authors.affiliation: Dept Psychiatry, University of North Carolina, Chapel Hill, NC.
authors.forename: John
authors.initials: J
authors.lastname: Gilmore
authors.affiliation: Dept Pediatrics, University of Pittsburgh, PA, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Escolar
authors.affiliation: Dept Psychiatry, University of North Carolina, Chapel Hill, NC ; Dept Computer Science, University of North Carolina, Chapel Hill, NC.
authors.forename: Martin
authors.initials: M
authors.lastname: Styner
keywords: 3D point correspondence; DTI; fiber feature map; large deformation fields