title: Coexisting atypical polypoid adenomyoma and endometrioid endometrial carcinoma in a young woman with Cowden Syndrome: Case report and implications for screening and prevention.
abstract: ► Cowden Syndrome is a rare hereditary cancer syndrome, which confers an increased risk of breast, thyroid, endometrial and colon cancer. ► Atypical polypoid adenomyoma does not generally represent a premalignant lesion, but must be carefully screened for foci of malignancy. ► Cancer screening must be intensified for patients who meet the diagnostic criteria for Cowden Syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Duke University Medical Center, DUMC Box 3616, Durham, NC, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Edwards
authors.affiliation: Department of Pathology, Maryview Medical Center, 3636 High Street, Portsmouth, VA 23707, USA.
authors.forename: Skylar
authors.initials: S
authors.lastname: Alsop
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia, PO Box 800712, Charlottesville, VA 22908, USA.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Modesitt
keywords: Atypical polypoid adenocarcinoma; Cowden Syndrome; Endometrial cancer