title: Natural compounds against flaviviral infections.
abstract: Arthropod borne flaviviral diseases are a major public health concern in the tropics. However, the majority of cases are associated with Dengue virus (DENV), Yellow Fever virus (YFV), West Nile virus (WNV) and Chikungunya virus (CHIKV) infections. Despite their profound clinical and economic impact among large sections of the population there is a lack of effective treatment against these diseases. A large number of plants are available in nature, which may act as a source for lead molecules against various diseases including arthropod borne flaviviral infections. In this review we discuss various crude extracts as well as purified compounds from natural sources with promising anti-DENV, YFV, WNV and CHIKV activity.
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India.
authors.forename: Md
authors.initials: M
authors.lastname: Abubakr
authors.affiliation: Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mandal
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India.
authors.forename: Sugato
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000627:therapeutic use*; D018178:Flaviviridae Infections / Q000188:drug therapy*; D005416:Flavivirus / Q000502:physiology; D006801:Humans; D009822:Oils, Volatile / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D001685:Biological Factors; D009822:Oils, Volatile; D010936:Plant Extracts