title: Risk factors for prehypertension in the community: a prospective analysis from the Western New York Health Study.
abstract: OBJECTIVE
  Prehypertension is an increasingly highly prevalent condition in the general population, and is associated with an increased risk for coronary heart disease and stroke. However, evidence from population-based studies of the risk factors for prehypertension is scant. We sought to examine the predictors of progression from normotension to prehypertension in a community-based population from Western New York.
  
  
  RESULTS
  A longitudinal analysis, over 6 years of follow-up, among 569 men and women (mean age 51.8 years) who were free of prehypertension, hypertension, cardiovascular disease and diabetes at the baseline examination, in the Western New York Health Study (WNYHS). Incident prehypertension at follow-up was defined as systolic blood pressure of 120-139 mm Hg and/or diastolic blood pressure of 80-89 mm Hg. The cumulative six year incidence of prehypertension was 33.5% (189/564). In bivariate analyses, there were several correlates of incident prehypertension, including age, BMI and waist circumference, impaired fasting glucose (IFG), uric acid, and baseline blood pressure levels. After multivariate adjustment, IFG at baseline [odds ratio (OR): 1.70, 95% CI: 1.07-2.69) and weight gain since age 25 (OR: 1.12, 1.04-1.21 per 10 lb increase)] were the strongest significant predictors of prehypertension at follow-up. Neither baseline waist circumference nor change in BMI were predictor variables in models when they were substituted for weight gain.
  
  
  CONCLUSIONS
  Results from this study suggest early dysregulation of glucose metabolism and weight gain over the lifespan may represent important risk factors for prehypertension in the general population.
authors.affiliation: Department of Social & Preventive Medicine, School of Public Health and Health Professions, State University of New York at Buffalo (SUNY), Buffalo, NY, USA. Electronic address: rpd1@buffalo.edu.
authors.forename: R P
authors.initials: RP
authors.lastname: Donahue
authors.affiliation: Department of Social & Preventive Medicine, School of Public Health and Health Professions, State University of New York at Buffalo (SUNY), Buffalo, NY, USA; Division of Health Sciences, University of Warwick Medical School, Coventry, UK.
authors.forename: S
authors.initials: S
authors.lastname: Stranges
authors.affiliation: Department of Health Policy, D'Youville College, Buffalo, NY, USA.
authors.forename: L
authors.initials: L
authors.lastname: Rafalson
authors.affiliation: Department of Mathematics and Statistics, University of North Carolina Charlotte, NC, USA.
authors.forename: J
authors.initials: J
authors.lastname: Dmochowski
authors.affiliation: Department of Exercise, Nutrition Science, School of Public Health and Health Professions, State University of New York at Buffalo (SUNY), Buffalo, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Dorn
authors.affiliation: School of Biomedical Education, City College of New York (CUNY), NY, USA.
authors.forename: M
authors.initials: M
authors.lastname: Trevisan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009518:New York; D058246:Prehypertension / Q000453:epidemiology* / Q000517:prevention & control*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D015430:Weight Gain
chemical_list: D001786:Blood Glucose
keywords: Blood pressure; Metabolic syndrome; Prehypertension; Prospective; Risk factors; Weight change