title: Co-delivery of small interfering RNA using a camptothecin prodrug as the carrier.
abstract: We have reported the first effort towards directly using an anticancer prodrug (CPTssR5H5) as a carrier to co-deliver camptothecin (CPT) and small interfering RNA for multidrug resistant cancer chemotherapy. The results indicated that CPTssR5H5 is a promising co-delivery system for MDR cancer therapy.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA. gc@uakron.edu.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D009842:Oligopeptides / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000972:Antineoplastic Agents, Phytogenic; D004220:Disulfides; D004337:Drug Carriers; D047908:Intracellular Signaling Peptides and Proteins; D009842:Oligopeptides; D011355:Prodrugs; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C481053:TAB3 protein, human; D002166:Camptothecin