title: Association between neurological and rheumatological manifestations in vitamin D deficiency and vitamin D levels.
abstract: OBJECTIVE
  We aimed to investigate the associations between the neurological manifestations of vitamin D deficiency and bone profile as well as the levels of 25-hydroxyvitamin D.
  
  
  METHODS
  We conducted a case series on patients with vitamin D deficiency who were followed up at King Abdulaziz Medical City, Jeddah between January 2010 and December 2011. We collected patients' demographic data and gathered information on etiological factors for vitamin D deficiency as well as clinical presentations (typical, neurological and rheumatological) and radiological findings. The t-test was used to determine whether there was an association between the neurological manifestations of vitamin D deficiency and vitamin D levels and bone profile.
  
  
  RESULTS
  We enrolled 60 patients with vitamin D deficiency. Of these, 44 (73.3%) had neurological presentations, namely progressive muscle weakness and proximal weakness, which was observed more often than distal weakness. In addition, gait disturbances were observed in 61.7% of all patients with neurological and rheumatological presentations. There was no significant association between neurological and rheumatological manifestations and bone profile or vitamin D levels. We found a significant association between difficulty in walking and the levels of serum calcium and phosphate (P = 0.043 and 0.037, respectively).
  
  
  CONCLUSIONS
  Neurological and rheumatologic manifestations of vitamin D deficiency are not associated with 25-hydroxyvitamin D levels or bone profile.
authors.affiliation: Faiza A. Qari, FRCP, ABIM, Department of Internal Medicine/Endocrinology, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Faiza
authors.initials: F
authors.lastname: A Qari
authors.affiliation: Tariq A. Nasser, ABIM, Department of Internal Medicine/Endocrinology, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Tariq
authors.initials: T
authors.lastname: A Nasser
keywords: Bone profile; Proximal myopathy; Vitamin D; Vitamin D deficiency