title: Antibacterial chromene and chromane stilbenoids from Hymenocardia acida.
abstract: Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against methicillin-resistant Staphylococcus aureus clinical isolate MRSA-108, including hymenocardichromanic acid, which was active at 8 μg/ml. None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines.
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States. Electronic address: cstarks@sequoiasciences.com.
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Starks
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Russell B
authors.initials: RB
authors.lastname: Williams
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Norman
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Rice
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Lawrence
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D013267:Stilbenes
keywords: Chromane; Chromene; Hymenocardia acida; Methicillin-resistant Staphylococcus aureus (MRSA); Phyllanthaceae