title: [Do we need congenital adrenal hyperplasia screening for premature infants?].
abstract: Congenital adrenal hyperplasia neonatal screening has been introduced in France since 1995. A recent survey has questioned its relevance in premature infants because of a high number of false positives and a low positive predictive value of 17-hydroxyprogesterone dosage. A workgroup at the French screening association (Association française de dépistage et de prévention des handicaps de l'enfant) collected all the epidemiological, clinical and biological data of premature children presenting with adrenal hyperplasia from the national cohort. Their results were compared with those of healthy premature children. All the data showed that the screening in children born before 32 weeks of gestational age is irrelevant, but that it is efficient after this term. A pilot study has been implemented in population to evaluate the opportunity to discontinue this screening in extreme preterm neonates.
authors.affiliation: Service de pédiatrie 1, hôpital d'enfants, CHU de Dijon, 21079 Dijon, France; Association française pour le dépistage et la prévention des handicaps de l'enfant, 38, rue Cauchy, 75015 Paris, France. Electronic address: frederic.huet@chu-dijon.fr.
authors.forename: F
authors.initials: F
authors.lastname: Huet
authors.affiliation: Service de pédiatrie 1, hôpital d'enfants, CHU de Dijon, 21079 Dijon, France. Electronic address: alice_godefroy@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Godefroy
authors.affiliation: Service maladies héréditaires du métabolisme et dépistage néonatal, hospices civils de Lyon, groupement hospitalier, Bron, France; Association française pour le dépistage et la prévention des handicaps de l'enfant, 38, rue Cauchy, 75015 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Cheillan
authors.affiliation: Service de biochimie et biologie moléculaire, hôpital de la Timone, AP-HM, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Somma
authors.affiliation: Pôle de pédiatrie médico-chirurgicale et de génétique médicale, CHU de Rennes, Rennes, France; Association française pour le dépistage et la prévention des handicaps de l'enfant, 38, rue Cauchy, 75015 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Roussey
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005602:France; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000453:epidemiology; D015997:Neonatal Screening; D010865:Pilot Projects; D011237:Predictive Value of Tests; D019564:Unnecessary Procedures
chemical_list: D019326:17-alpha-Hydroxyprogesterone