title: Combination corticosteroid/β-agonist inhaler as reliever therapy: a solution for intermittent and mild asthma?
abstract: The recommended treatment of mild asthma is regular maintenance inhaled corticosteroids (ICSs) with a short-acting β-agonist as a separate inhaler used when needed for symptom relief. However, the benefits of regular ICS use in actual clinical practice are limited by poor adherence and low prescription rates. An alternative strategy would be the symptom-driven (as-required or "prn") use of a combination ICS/short-acting β-agonist or ICS/long-acting β-agonist inhaler as a reliever rather than regular maintenance use. The rationale for this approach is to titrate both the ICS and β-agonist dose according to need and enhance ICS use in otherwise poorly adherent patients who overrely on their reliever β-agonist inhaler. This strategy will only work if the β-agonist component has a rapid onset of action for symptom relief. There is evidence to suggest that this regimen has advantages over regular ICS therapy and might represent an effective, safe, and novel therapy for the treatment of intermittent and mild asthma. In this commentary we review this evidence and propose that randomized controlled trials investigating different combination ICS/β-agonist inhaler products prescribed according to this regimen in intermittent and mild asthma are an important priority.
authors.affiliation: Medical Research Institute of New Zealand, Wellington, New Zealand. Electronic address: Richard.Beasley@mrinz.ac.nz.
authors.forename: Richard
authors.initials: R
authors.lastname: Beasley
authors.affiliation: Department of Medicine, University of Otago Wellington, Wellington, New Zealand.
authors.forename: Mark
authors.initials: M
authors.lastname: Weatherall
authors.affiliation: Medical Research Institute of New Zealand, Wellington, New Zealand.
authors.forename: Philippa
authors.initials: P
authors.lastname: Shirtcliffe
authors.affiliation: Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Robert
authors.initials: R
authors.lastname: Hancox
authors.affiliation: Clinical Medical Group, Woolcock Institute of Medical Research, Sydney, Australia.
authors.forename: Helen K
authors.initials: HK
authors.lastname: Reddel
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000008:administration & dosage; D006801:Humans; D009330:Nebulizers and Vaporizers; D010349:Patient Compliance; D016032:Randomized Controlled Trials as Topic
chemical_list: D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D004983:Ethanolamines; D019819:Budesonide
keywords: Asthma; ICS; Inhaled corticosteroid; LABA; Long-acting β-agonist; RCT; Randomized controlled trial; SABA; SMART; Short-acting β-agonist; Single combination budesonide-formoterol inhaler maintenance and reliever therapy; combination therapy; inhaled steroid; β-agonist