title: [The expression of ubiquitin in laryngeal squamous cell carcinoma with lymph node metastasis and its clinical significance].
abstract: OBJECTIVE
  To investigate the ubiquitin expression in laryngeal squamous cell carcinoma (LSCC) whether along with local lymph node metastasis, and further study its correlation with local lymph node metastasis and other clinicopathological parameters in laryngeal squamous cell carcinoma.
  
  
  METHODS
  We detected the different expression level of ubiquitin in paraffin specimens between 19 cases of LSCC associated with cervical lymph node metastasis LSCC(N+) and 20 cases of LSCC not associated with cervical lymph node metastasis LSCC(N-) by immunohistochemical staining combined with stereology image analysis system. Statistics were analyzed by student test, variance analysis and ROC curve.
  
  
  RESULTS
  Ubiquitin expression in LSCC(N+) was significantly higher than LSCC(N-) (P < 0.01); their expression level was not correlated with age,history of tobacco, alcohol addiction, clinical stage and primary site,etc.
  
  
  CONCLUSIONS
  Ubiquitin was significantly up-expressed in LSCC(N+) than ILSCC (N-), which may imply that it is one of the important elements in mechanism of lymph node metastasis in LSCC.
authors.affiliation: Department of Otolaryngoloy, the First Hospital of Quanzhou, Fujian Medical University, Quanzhou, 362000, China.
authors.forename: Gengming
authors.initials: G
authors.lastname: Cai
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Gangcai
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Changyun
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Haolei
authors.initials: H
authors.lastname: Tan
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
authors.forename: Donghai
authors.initials: D
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000077195:Squamous Cell Carcinoma of Head and Neck; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D025801:Ubiquitin