title: Evaluation of the efficacy of 2-hydroxy-4-methylselenobutanoic acid on growth performance and tissue selenium retention in growing pigs.
abstract: The aim of this study was to compare the efficacy of a new organic Se (2-hydroxy-4-methylselenobutanoic acid [HMSeBA]) source (SO) with sodium selenite (SS) and selenized yeast (SY) at various dietary levels for growth performance and tissue Se deposition in growing pigs. A total of 112 crossbred (Pietrain × [Large White × Landrace]) gilts were allotted at an average body weight of 26.73 kg to 7 dietary treatments with 8 replicate pens of 2 pigs per pen. Pigs were fed basal diets unsupplemented or supplemented either with SS, SY, or SO each at 0.1 or 0.3 mg Se/kg of diet for 32 d. Feed intake and BW were recorded during the experimental period. At the end of the experiment, blood, liver, and psoas major muscle of all gilts were collected for total Se and relative bioavailability determination. No differences were observed on final BW, ADG, ADFI, and G:F among dietary treatments. All Se-supplemented groups exhibited greater total Se contents in plasma (P < 0.01) and liver (P < 0.01) compared with unsupplemented control group. However, Se retention in psoas major muscle was improved only when organic Se source (SY or SO) was added to diets (P < 0.01). Regardless the Se level, the Se deposition in muscle was greater (P < 0.01) in pigs supplemented with SO than those supplemented with SY. Slope ratio assay confirmed the greater bioavailability of Se from organic compared with inorganic Se and also revealed that the relative bioavailability of Se from HMSeBA for plasma, liver, and muscle Se response was 170, 141, and 162%, respectively, for SY. This study shows a potential advantage of HMSeBA supplementation in the increase of Se contents in pig tissues, indicating that this new organic Se source could be an alternative source of Se in swine nutrition.
authors.affiliation: Adisseo France S.A.S., 10, Place du Général de Gaulle, 92160 Antony, France.
authors.forename: M
authors.initials: M
authors.lastname: Jlali
authors.forename: M
authors.initials: M
authors.lastname: Briens
authors.forename: F
authors.initials: F
authors.lastname: Rouffineau
authors.forename: P-A
authors.initials: PA
authors.lastname: Geraert
authors.forename: Y
authors.initials: Y
authors.lastname: Mercier
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001682:Biological Availability; D002087:Butyrates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D008099:Liver / Q000378:metabolism; D013058:Mass Spectrometry; D018482:Muscle, Skeletal / Q000378:metabolism; D011897:Random Allocation; D018036:Selenium Compounds / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D018038:Sodium Selenite / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D034421:Sus scrofa / Q000254:growth & development / Q000378:metabolism*
chemical_list: C551033:2-hydroxy-4-methylselenobutanoic acid; D002087:Butyrates; D018036:Selenium Compounds; D018038:Sodium Selenite