title: Prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid.
abstract: Objective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and morbidity. This complication occurs in about 15% of infants and is more widespread in postterm neonates. About 1.5 percent of neonates with MSAF develop meconium aspiration syndrome. Method. Sera of 29 umbilical cord blood of infants with MSAF and 32 healthy infants (HI) were collected. Both groups had nonsmoker and non-alcoholic mothers with no diseases. The PAB was measured. Result. There was a significant increase of PAB value (32.8 ± 15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5 ± 12.6 HK) (P < 0.05). There was no significant correlation between PAB value and age of mothers. Conclusion. The increased PAB value in infants with MSAF showed that these infants are exposed to oxidative stress. Further research with larger population is needed to demonstrate the oxidative stress in infants with MSAF.
authors.affiliation: Department of Biology, School of Sciences, Payame Noor University, Mashhad 91735433, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Arjmand
authors.affiliation: Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad 9137913316, Iran.
authors.forename: Farhat
authors.initials: F
authors.lastname: Ahmad Shah
authors.affiliation: Department of Chemistry, School of Science, Payame Noor University, Mashhad 91735433, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Saleh Moghadam
authors.affiliation: Department of Obstetrics and Gynecology, OM-Albanin Hospital, Mashhad University of Medical Sciences, Mashhad 9144663595, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tara
authors.affiliation: Department of New Science and Technologies, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Jalili
authors.affiliation: Department of Social Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9138913131, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Mosavi Bazaz
authors.affiliation: Stem Cell and Regenerative Medicine Research Group, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors.forename: Daryoush
authors.initials: D
authors.lastname: Hamidi Alamdari