title: Radiolabeled neurogenesis marker imaging: a revolution in the neurological diseases management?
abstract: A reduced rate of neurogenesis occurs in the adult brain of patients with neurological diseases, with the rate of new neuron proliferation not sufficient to replace neuron loss. Neurogenesis can be induced by several factors, including basic fibroblast growth factor, epidermal growth factor, and brain-derived neurotrophic factor. Neurogenesis determination is a valuable parameter for determining disease progression and monitoring various treatments. Currently, neurogenesis detection is possible by invasive methods, such as bromodeoxyuridine (BrdU) cell labeling and immunohistological analysis of immature neuron markers. However, these are not compatible with alive model examination. Neurogenesis detection by noninvasive methods, such as radiolabeling of specific antibodies and scintigraphy imaging, could shed light on immature neuronal markers. We propose that brain scintigraphy after radiolabeling of a specific antibody of an immature neuronal marker is a useful new modality for neurogenesis detection and that it would aid the management of neurological diseases.
authors.affiliation: Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Nemati
authors.affiliation: Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mehdizadeh
authors.affiliation: Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
authors.affiliation: Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Hooman
authors.initials: H
authors.lastname: Salimipour
authors.affiliation: Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Darioush
authors.initials: D
authors.lastname: Iranpour
authors.affiliation: The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: assadipoya@yahoo.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging* / Q000196:embryology / Q000254:growth & development; D064032:Calbindin 2 / Q000378:metabolism; D018450:Disease Progression; D000089622:Doublecortin Domain Proteins; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008962:Models, Theoretical; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000628:therapy*; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism; D009474:Neurons / Q000473:pathology / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods; D012794:Sialic Acids / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D015415:Biomarkers; D064032:Calbindin 2; D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D039842:Neural Cell Adhesion Molecule L1; D009479:Neuropeptides; D011868:Radioisotopes; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule; C093564:Neurogenic differentiation factor 1