title: [Utility of hCG dosage in the management of gestational trophoblastic diseases].
abstract: Measurement of hCG remains today central for diagnosis, treatment and follow-up of gestational trophoblastic diseases (GTD). In order to evaluate this contribution, we conducted a prospective cohort study in the Service of high-risk pregnancy of Rabat Maternity Les Orangers and the Laboratory of Rabat Military Teaching Hospital Mohammed V over a period of eighteen months. 35 patients were included. The hCG assay was determined by electrochemiluminescence. The general frequency of the GTD is of 0.33/100 childbirth. The average age of our patients was 30.5 years. 26 patients had hCG level abnormal and higher than 200 000 UI/mL when diagnosed with GTD; 34 patients had simple endo-uterine aspiration and 1 a chemotherapy. Among 34 patients, 25 (73.5%) had a favourable evolution characterized by normal hCG level within 3 to 13 weeks and complete remission. Serum hCG remained stable and negative in all these patients with a follow-up of 18 months. 9 patients had unfavourable evolution characterized by reaxent after negativation or stagnation of hCG levels. A rigorous monitoring of hCG levels during treatment and follow-up is essential to improve forecast of these diseases.
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Alban Gildas Comlan
authors.initials: AG
authors.lastname: Zohoun
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Karl
authors.initials: K
authors.lastname: Hounmenou
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Samira El Idrissi
authors.initials: Sel I
authors.lastname: Mechtani
authors.affiliation: Laboratoire de biostatistique, de recherche clinique, Faculté de médecine et de pharmacie, Rabat, Maroc.
authors.forename: Rachid
authors.initials: R
authors.lastname: Razine
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Abdellah
authors.initials: A
authors.lastname: Dami
authors.affiliation: Service des grossesses à risque, Maternité universitaire Les Orangers, Rabat, Maroc.
authors.forename: Adib
authors.initials: A
authors.lastname: Filali
authors.affiliation: Service de gynécologie-obstétrique, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Driss Moussaoui
authors.initials: DM
authors.lastname: Rahali
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
authors.forename: Saida
authors.initials: S
authors.lastname: Tellal
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis* / Q000097:blood; D015331:Cohort Studies; D004358:Drug Therapy / Q000706:statistics & numerical data; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D009018:Morocco / Q000453:epidemiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D014619:Vacuum Curettage / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin
keywords: Morocco; gestational trophoblastic diseases; hCG; management