title: Lucio's phenomenon. Case study of an exceptional response to treatment exclusively with multibacillary multidrug therapy.
abstract: Lucio's phenomenon represents a serious cutaneous necrotizing reaction, which can occur with Lucio's leprosy and also in other forms of lepromatous leprosy. The authors discuss the case of a 63-year-old male patient presenting with ulcers and necrotic cutaneous lesions on the limbs, torso and face, associated with recurring sinusitis, hoarseness and a weight loss of 25 kilos over the last year. Bacilloscopy of intradermal scrapings showed a bacilloscopic index of 5 and the histopathological findings were compatible with the diagnosis of Lucio's phenomenon. The chosen treatment was exclusively multibacillary multidrug therapy, resulting in important dermatological improvement after one month of therapy. The authors present an impressive case of Lucio's phenomenon with an exceptional response to treatment exclusively with multibacillary multidrug therapy.
authors.affiliation: Marcílio Dias Naval Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Amanda Braga
authors.initials: AB
authors.lastname: Peixoto
authors.affiliation: Marcílio Dias Naval Hospital, Rio de JaneiroRJ, Brazil.
authors.forename: Poliana Santin
authors.initials: PS
authors.lastname: Portela
authors.affiliation: Rio de Janeiro Pontifical Catholic University.
authors.forename: Fabiano Roberto Pereira de Carvalho
authors.initials: FR
authors.lastname: Leal
authors.affiliation: Rio de Janeiro State University.
authors.forename: Arles Martins
authors.initials: AM
authors.lastname: Brotas
authors.affiliation: Marcílio Dias Naval Hospital dermatology clinics, Rio de JaneiroRJ, Brazil.
authors.forename: Nilton Carlos dos Santos
authors.initials: NC
authors.lastname: Rodrigues
mesh_terms: D001706:Biopsy; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007917:Leprostatic Agents