title: Naltrexone reverses ethanol-induced rat hippocampal and serum oxidative damage.
abstract: Naltrexone, an antagonist of μ-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed.
authors.affiliation: Departamento de Ciencias Biomédicas, Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Moncada, 46113 Valencia, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Almansa
authors.affiliation: Facultad de Medicina, Universidad Católica de Valencia "San Vicente Mártir", C/ Quevedo 2, 46001 Valencia, Spain.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Barcia
authors.affiliation: Departamento de Ciencias Biomédicas, Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Moncada, 46113 Valencia, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: López-Pedrajas
authors.affiliation: Facultad de Ciencias de la Salud, Universitat Jaume I, 12071 Castellón, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Muriach
authors.affiliation: Departamento de Ciencias Biomédicas, Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Moncada, 46113 Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Miranda
authors.affiliation: Facultad de Medicina, Universidad Católica de Valencia "San Vicente Mártir", C/ Quevedo 2, 46001 Valencia, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Romero
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D000431:Ethanol; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009271:Naltrexone / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D000431:Ethanol; D008315:Malondialdehyde; D009271:Naltrexone