title: Oat beta-glucan ameliorates insulin resistance in mice fed on high-fat and high-fructose diet.
abstract: METHODS
  This study sought to evaluate the impact of oat beta-glucan on insulin resistance in mice fed on high-fat and high-fructose diet with fructose (10%, w/v) added in drinking water for 10 weeks.
  
  
  RESULTS
  The results showed that supplementation with oat beta-glucan could significantly reduce the insulin resistance both in low-dose (200 mg/kg(-1) body weight) and high-dose (500 mg/kg(-1) body weight) groups, but the high-dose group showed a more significant improvement in insulin resistance (P<0.01) compared with model control (MC) group along with significant improvement in hepatic glycogen level, oral glucose, and insulin tolerance. Moreover, hepatic glucokinase activity was markedly enhanced both in low-dose and high-dose groups compared with that of MC group (P<0.05).
  
  
  CONCLUSIONS
  These results suggested that supplementation of oat beta-glucan alleviated insulin resistance and the effect was dose dependent.
authors.affiliation: College of Food Science, Southwest University, Chongqing, China ; Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.
authors.forename: Nanhui
authors.initials: N
authors.lastname: Shen
authors.affiliation: Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.
authors.forename: Shuanghui
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Food Science, Southwest University, Chongqing, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhao
keywords: high-fat; high-fructose; insulin resistance; mice; oat beta-glucan