title: Meta-analysis of the association of glutathione S-transferase T1 null/presence gene polymorphism with the risk of gastric carcinoma.
abstract: A possible association of glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and an increased risk of developing gastric carcinoma is still unclear and hotly debated. This investigation was performed to assess the association of the GSTT1 null/presence gene polymorphism with the risk of gastric carcinoma via a meta-analysis to increase sample size and statistical significance. PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) were searched on March 1, 2013, association reports were identified, and eligible studies were recruited and synthesized. Fifty-two reports were found to be suitable for this meta-analysis for the association of the GSTT1 null genotype with gastric carcinoma risk. The results showed that there was a significantly increased gastric carcinoma risk when the GSTT1 null genotype was present in the overall population (OR 1.21, 95 % CI 1.11-1.32, P < 0.0001), Caucasians (OR 1.25, 95 % CI 1.05-1.48, P = 0.01), East-Asians (OR 1.18, 95 % CI 1.06-1.31, P = 0.003), and Chinese (OR 1.24, 95 % CI 1.07-1.44, P = 0.005). However, no statistically relevant association could be established for the Indian ethnic group (OR 1.33, 95 % CI 0.94-1.90, P = 0.11). In conclusion, the GSTT1 null genotype is associated with an increased gastric carcinoma risk in the overall population, Caucasians, East-Asians, and Chinese.
authors.affiliation: Department of General Surgery, The West District of the First Affiliated Hospital of GuangXi Medical University, Nanning, 530021, China.
authors.forename: Yuan-Biao
authors.initials: YB
authors.lastname: Meng
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Cai
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Lu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yang
authors.forename: Ting-Qing
authors.initials: TQ
authors.lastname: Gan
authors.forename: Gregor P C
authors.initials: GP
authors.lastname: Drummen
mesh_terms: D044466:Asian People / Q000235:genetics; D002277:Carcinoma; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D044465:White People / Q000235:genetics
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase