title: Seizures, Cerebral Shutdown, and SUDEP.
abstract: Several potential pathophysiologic phenomena, including "cerebral shutdown," are postulated to be responsible for SUDEP. Since the evidence for a seizure-related mechanism is strong, a poor understanding of the physiology of human seizure termination is a major handicap. However, rather than a failure of a single homeostatic mechanism, such as postictal arousal, it may be a "perfect storm" created by the lining up of a several factors that lead to death.
authors.affiliation: Epilepsy Center, University Hospitals Case Medical Center, Cleveland, OH.
authors.forename: Alireza
authors.initials: A
authors.lastname: Bozorgi
authors.affiliation: Epilepsy Center, University Hospitals Case Medical Center, Cleveland, OH.
authors.forename: Samden D
authors.initials: SD
authors.lastname: Lhatoo