title: Synchronous appearance of a high-grade neuroendocrine carcinoma of the ampulla vater and sigmoid colon adenocarcinoma.
abstract: Neuroendocrine carcinoma is a relatively rare tumor and its coexistence with other primary cancers is very exceptional. We present a case of a 63-year-old woman with biliary obstruction due to a high-grade neuroendocrine carcinoma located in ampulla of Vater who was found to have a synchronous sigmoid colon adenocarcinoma while undergoing staging laparotomy and pancreas head resection. Medical history was significant only for basal cell skin cancer. Immunohistochemical examination revealed the concurrence of histologically proved neuroendocrine carcinoma (chromogranin A, synaptophysin, and CD56 were positive) and Stage II (T3, N0, and M0) according to the TNM staging classification of colorectal cancer. The coexistence of neuroendocrine tumors with either synchronous or metachronous unrelated cancer is increasingly recognized. The patients with neuroendocrine carcinoma should be evaluated for secondary primary malignancies.
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Cokmert
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Demir
authors.affiliation: Department of Pathology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Akder Sari
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Can
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Akyol
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Ibrahim Vedat
authors.initials: IV
authors.lastname: Bayoglu
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirican
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Erten
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Izmir Katip Celebi University, 35600 Izmir, Turkey.
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan