title: Interaction between MAOA and FOXP2 in association with autism and verbal communication in a Korean population.
abstract: Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. For this reason, we undertook interaction analysis between MAOA and FOXP2 in autism spectrum disorder, including testing the verbal communication score of the childhood autism rating scale. In interaction analysis, the FOXP2-TCGC (rs12531289-rs1350135-rs10230087-rs2061183) diplotype and MAOA-TCG (rs6323-rs1801291-rs3027407) haplotype were significantly associated with autism spectrum disorder in males. However, when the interaction term was omitted, neither MAOA nor FOXP2 was associated with autism spectrum disorder or verbal communication. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately.
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
authors.forename: YoungJoon
authors.initials: Y
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
authors.forename: SeongSik
authors.initials: S
authors.lastname: Won
authors.affiliation: Seoul Metropolitan Children's Hospital, Heolleungno, Seocho-gu, Seoul, Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Nam
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea kbkwack@cha.ac.kr.
authors.forename: KyuBum
authors.initials: K
authors.lastname: Kwack
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D003141:Communicable Diseases / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D014705:Verbal Behavior / Q000502:physiology; D055815:Young Adult
chemical_list: C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: FOXP2; MAOA; autism spectrum disorder