title: Pterocarpans from the root bark of Aeschynomene fascicularis.
abstract: A new pterocarpan, aeschynocarpin (1), and the known pterocarpan 2-methoxymedicarpin (2) were isolated for the first time from Aeschynomene fascicularis (Fabaceae) and their structures elucidated by means of spectroscopic {UV/Vis, IR, and NMR (1H, 13C, COSY, HMQC,and HMBC)} andmass spectrometric (EI-MS and HRCIMS) techniques. Both compounds were tested in vitro for their cytotoxic and antiproliferative activities against a panel of cancer cell lines. This is the first report on the presence of pterocarpans in the genus Aeschynomene.
authors.affiliation: Unidad de Biotecnologia, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida, Yucatán 97200, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Caamal-Fuentes
authors.affiliation: Unidad de Investigación Medica Yucatán, Unidad Médica de Alta Especialidad, Centro Médico Ignacio Garcia Thélez, Instituto Mexicano del Seguro Social, Calle 41 No. 439, Col. Industrial, Mérida, Yucatán 97150, México.
authors.forename: Rosa
authors.initials: R
authors.lastname: Moo-Puc
authors.affiliation: Unidad de Biotecnologia, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida, Yucatán 97200, Mexico.
authors.forename: Luis W
authors.initials: LW
authors.lastname: Torres-Tapia
authors.affiliation: Unidad de Biotecnologia, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida, Yucatán 97200, Mexico.
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Peraza-Sanchez
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036343:Pterocarpans; C585944:aeschynocarpin