title: The association between vasomotor symptoms and depression during perimenopause: a systematic review.
abstract: There is a high incidence of depression in women presenting to menopause clinics. The aim of this review was to determine if there is an association between depressive symptoms or major depressive disorder (MDD) and vasomotor symptoms (VMS). A systematic review of the literature was conducted according to PRISMA guidelines. 33 relevant publications were found, 12 from three large studies. Overall, we found that there is a bidirectional association between VMS and depressive symptoms. This has been established in well-conducted, large observational studies. There does not appear to be a relationship between VMS and MDD. However, studies examining VMS and MDD were prone to bias making it difficult to draw any conclusions.
authors.affiliation: Women's Health Research Program, School of Public Health and Preventive Medicine; Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia; Monash Alfred Psychiatry Research Centre, Monash University, Level 4, 607 St Kilda Road, Melbourne, VIC 3004, Australia. Electronic address: roisin.worsley@monash.edu.
authors.forename: Roisin
authors.initials: R
authors.lastname: Worsley
authors.affiliation: Women's Health Research Program, School of Public Health and Preventive Medicine; Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia.
authors.forename: Robin
authors.initials: R
authors.lastname: Bell
authors.affiliation: Monash Alfred Psychiatry Research Centre, Monash University, Level 4, 607 St Kilda Road, Melbourne, VIC 3004, Australia.
authors.forename: Jayashri
authors.initials: J
authors.lastname: Kulkarni
authors.affiliation: Women's Health Research Program, School of Public Health and Preventive Medicine; Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia.
authors.forename: Susan R
authors.initials: SR
authors.lastname: Davis
mesh_terms: D003863:Depression / Q000150:complications* / Q000503:physiopathology; D005260:Female; D019584:Hot Flashes / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D047648:Perimenopause / Q000502:physiology / Q000523:psychology*; D014666:Vasomotor System / Q000503:physiopathology*
keywords: Depression; Hot flushes; Major depressive disorder; Perimenopause; Vasomotor