title: Fesoterodine fumarate and the oxybutynin ring for the treatment of urinary incontinence in women.
abstract: BACKGROUND
  Urinary incontinence (UI) is a prevalent condition among women of all ages. It can have a significant negative impact on women's quality of life causing not only physical but also psychological distress.
  
  
  METHODS
  This article aims to provide a review of the pharmacology, efficacy, safety and tolerability of fesoterodine fumarate (the newest anticholinergic launched in the UK) and the oxybutynin vaginal ring (the newest route of drug delivery in development) in the treatment of urgency UI.
  
  
  CONCLUSIONS
  Fesoterodine is now a well-established treatment option; however, as with all oral anticholinergic agents its use is hindered by side effects. The efficacy of the oxybutynin ring has only been demonstrated in small studies. Larger clinical trials assessing the efficacy, tolerability and acceptability are required before appropriate recommendations can be made.
authors.affiliation: King's College Hospital , Denmark Hill, London, SE5 9RS , UK +0203 299 3568 ; +0203 299 3449 ; angela.rantell@nhs.net.
authors.forename: Angie
authors.initials: A
authors.lastname: Rantell
authors.forename: Linda
authors.initials: L
authors.lastname: Cardozo
authors.forename: Sushma
authors.initials: S
authors.lastname: Srikrishna
mesh_terms: D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D003274:Contraceptive Devices, Female; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008333:Mandelic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy; D014549:Urinary Incontinence / Q000188:drug therapy*; D064804:Urological Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001559:Benzhydryl Compounds; D018680:Cholinergic Antagonists; D008333:Mandelic Acids; D064804:Urological Agents; C526675:fesoterodine; C005419:oxybutynin