title: [Chlorpromazine-induced status epilepticus: a case report].
abstract: BACKGROUND
  It is largely known that some antipsychotic agents could have proconvulsive and proepileptogenic effects in some patients and could induce EEG abnormalities as well. However, the association of status epilepticus with certain antipsychotic drugs has been very rarely reported.
  
  
  METHODS
  A case of an 18-year-old adolescent girl, with chlorpromazine therapy started for anxiety-phobic disorder was reported. Her personal history disclosed delayed psychomotor development. Shortly after the introduction of the neuroleptic chlorpromazine therapy in minimal daily dose (37.5 mg), she developed myoclonic status epilepticus, confirmed by the EEG records. Frequent, symmetrical bilateral myoclonic jerks and altered behavior were associated with bilateral epileptiform discharges of polyspikes and spike-wave complexes. This epileptic event lasted 3.5 hours and it was stopped by the parenteral administration ofvalproate and lorazepam; she was EEG monitored until stable remission. Status epilepticus as initial epileptic event induced by neuroleptic agent was not previously reported in our national literature.
  
  
  CONCLUSIONS
  Introduction of chlorpromazine to a patient without history of seizures is associated with the evolution of an epileptic activity, including the occurrence of status epilepticus. Clinical evaluation of the risk factors possibly related to chlorpromazine-induced seizure is recommended in individual patients before administering this drug.
authors.affiliation: Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia. dragana.momcilovic.npk@gmail.com
authors.forename: Dragana
authors.initials: D
authors.lastname: Momcilović-Kostadinović
authors.affiliation: Institute for Mental Health, Belgrade, Serbia.
authors.forename: Perisa
authors.initials: P
authors.lastname: Simonović
authors.affiliation: Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia.
authors.forename: Dusan
authors.initials: D
authors.lastname: Kolar
authors.affiliation: Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia.
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Jović
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000188:drug therapy*; D002746:Chlorpromazine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012307:Risk Factors; D013226:Status Epilepticus / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine