title: Modulation of short- and long-interval intracortical inhibition with increasing motor evoked potential amplitude in a human hand muscle.
abstract: OBJECTIVE
  The aim of the current study was to investigate the effect of increasing test motor evoked potential (MEP) amplitude on short- (SICI) and long-interval intracortical inhibition (LICI) at rest and during activation of the first dorsal interosseous (FDI) muscle.
  
  
  METHODS
  In 22 young subjects, a conditioning-test transcranial magnetic stimulation (TMS) paradigm was used to assess SICI and LICI at 5 different test TMS intensities (110-150% motor threshold) in resting and active FDI. In 9 additional subjects, SICI and LICI data were quantified when the test MEP amplitude represented specific proportions of the maximal compound muscle action potential (Mmax) in each subject.
  
  
  RESULTS
  Test TMS intensity influenced SICI and LICI in rest and active FDI muscle. The normalised test MEP amplitude (%Mmax) did not influence SICI at rest, whereas there was a decrease in LICI at rest and an increase in SICI in active FDI with an increased normalised test MEP amplitude (%Mmax).
  
  
  CONCLUSIONS
  Our results demonstrate differential effects of normalised test MEP amplitude (%Mmax) on SICI and LICI in resting and active FDI muscle.
  
  
  CONCLUSIONS
  Estimation of SICI and LICI under some circumstances may be influenced by the normalised test MEP amplitude in subject populations with different Mmax characteristics.
authors.affiliation: Discipline of Physiology, School of Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: George M
authors.initials: GM
authors.lastname: Opie
authors.affiliation: Discipline of Physiology, School of Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: john.semmler@adelaide.edu.au.
authors.forename: John G
authors.initials: JG
authors.lastname: Semmler
mesh_terms: D000200:Action Potentials; D000328:Adult; D000704:Analysis of Variance; D003213:Conditioning, Psychological; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006225:Hand / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D016014:Linear Models; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
keywords: Intracortical inhibition; Motor evoked potential; Muscle activation; Transcranial magnetic stimulation