title: Risk of obstructive sleep apnea in Parkinson's disease: a meta-analysis.
abstract: OBJECTIVE
  Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis review is to evaluate the association between PD and the prevalence of OSA.
  
  
  METHODS
  A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model.
  
  
  RESULTS
  Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model.
  
  
  CONCLUSIONS
  Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls.
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.affiliation: Sleep Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Taoping
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Urology, Nanfang hospital, Southern Medical University, Guangzhou, Guangdong. P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Sleep Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong, P. R. China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D010300:Parkinson Disease / Q000150:complications*; D015995:Prevalence; D011785:Quality Assurance, Health Care; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000209:etiology*