title: Metabolic fuelling of proper T cell functions.
abstract: The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function.
authors.affiliation: Dipartimento di Medicina e Chirurgia, Università di Salerno, Baronissi Campus, Baronissi 84081, Salerno, Italy; IRCCS-MultiMedica, Milano 20138, Italy. Electronic address: gmatarese@unisa.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matarese
authors.affiliation: Unità di NeuroImmunologia, IRCCS-Fondazione Santa Lucia, Roma 00143, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Colamatteo
authors.affiliation: Unità di NeuroImmunologia, IRCCS-Fondazione Santa Lucia, Roma 00143, Italy; Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli 80131, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: De Rosa
mesh_terms: D000818:Animals; D006019:Glycolysis; D006801:Humans; D056747:Immunomodulation; D050356:Lipid Metabolism; D008213:Lymphocyte Activation; D053858:Metabolic Networks and Pathways; D010084:Oxidation-Reduction; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
chemical_list: D058570:TOR Serine-Threonine Kinases
keywords: Adipose tissue; Metabolism; T cell; Tolerance; Treg cell