title: Antitumor activities of Juemingzi (Cassia toraL.) on Balb/c sarcoma 180-injected mice.
abstract: The antitumor activity of Juemingzi (Cassia toraL.) was investigated in mice that were fed various concentrations of the compound. Although mice fed a low concentration (50 mg/kg b.w.) of Juemingzi exhibited a high tumor weight, the higher feeding concentrations (100 and 200 mg/kg b.w.) were associated with lower weight tumors. The growth rate of mouse splenocytes that were treated with 200 mg/kg b.w. Juemingzi was determined using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. This rate of proliferation was higher than that achieved with 100 and 50 mg/kg b.w. Juemingzi treatment by fetal bovine serum, lipopolysaccharide or concanavalin A. Compared with the lower concentrations of Juemingzi treatment, 200 mg/kg b.w. Juemingzi significantly (P<0.05) reduced aspartate aminotransferase, alanine transaminase and blood urea nitrogen levels. A high concentration of Juemingzi (200 mg/kg b.w.) significantly (P<0.05) increased the levels of tumor necrosis factor-α and interleukin-1β cytokines compared with those of the mice that were treated with 100 and 50 mg/kg b.w. Juemingzi.
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Shaocheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Guijie
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
keywords: Balbc/c mice; Juemingzi; sarcoma 180; tumor