title: Isolated granulocytic sarcoma of the nasopharynx: a case report and review of the literature.
abstract: Granulocytic sarcoma (GS) is a rare extramedullary manifestation of acute myeloid leukemia (AML). It may also represent blastic transformation of myelodysplastic syndromes or myeloproliferative neoplasms. Although usually seen in the context of advanced and poorly controlled disease, it may also present as the first manifestation of illness, without concurrent bone marrow or blood involvement. In the medical literature, chloroma and GS are terms that have been used interchangeably with myeloid sarcoma. GS usually manifests as soft tissue or bony masses in several extracranial sites, such as bone, periosteum, and lymph nodes; involvement of the head and neck region is uncommon. We report a case of a woman with insidious onset of progressive nasal congestion and diminished hearing who was diagnosed with an isolated GS of the nasopharynx. With involved field radiotherapy, she achieved a complete remission of 12-months duration before being diagnosed with overt AML. She has remained disease-free for greater than 18 months following induction and consolidation chemotherapy. Through a MEDLINE®/PubMed® search we identified an additional 13 cases of nasopharyngeal GS. The median age was 37 years (range 1 to 81 years). The cases were equally distributed among the sexes. The most common presenting symptoms were conductive hearing loss and sinonasal congestion. Isolated GS was identified in six cases, and the median time from diagnosis of GS to AML was 12 months (range 3 to 48 months). The treatment varied, but responses were seen in all the patients who received chemotherapy with or without radiotherapy.
authors.affiliation: Floyd and Delores Jones Cancer Institute at Virginia Mason Medical Center, Seattle, WA, USA.
authors.forename: Prakash
authors.initials: P
authors.lastname: Vishnu
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Ravindra Reddy
authors.initials: RR
authors.lastname: Chuda
authors.affiliation: Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA.
authors.forename: Dick G
authors.initials: DG
authors.lastname: Hwang
authors.affiliation: Floyd and Delores Jones Cancer Institute at Virginia Mason Medical Center, Seattle, WA, USA ; Division of Hematology, University of Washington, Seattle, WA, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Aboulafia
keywords: acute myeloid leukemia; chloroma; myeloid sarcoma; treatment