title: Anti-HLA and anti-MICA antibodies in liver transplant recipients: effect on long-term graft survival.
abstract: OBJECTIVE
  Presence of anti-HLA antibodies has a well-known impact on kidney grafts survival; however their role in liver transplantation has not been fully elucidated. We conducted a 7-year prospective study to show correlation between presence of anti-HLA and anti-MICA antibodies and liver graft survival.
  
  
  METHODS
  Blood samples from 123 liver transplant recipients were collected during patients routine visits. Time from transplantation to blood sample collection was different for each patient. Blood samples were tested for anti-HLA (separately class I and II) and MICA antibodies using Luminex assays.
  
  
  RESULTS
  There were 32 (26%) patients with positive anti-HLA and 37 (30%) with positive anti-MICA antibodies. Graft loss occurred in 7 cases (23%) in anti-HLA positive group compared to 20 (22%) in anti-HLA negative group (P = ns) and in 8 cases (22%) in anti-MICA positive group but 19 (23%) in anti-MICA negative group (P = ns). No correlations were detected between presence of antibodies and acute graft rejection (AGR). Presence of any antibodies (anti-HLA or anti-MICA antibodies) correlated with late graft rejection (P = 0.04).
  
  
  CONCLUSIONS
  Presence of anti-HLA or anti-MICA had no impact on long-term liver graft survival; however, detection of any antibodies was correlated with episodes of late graft rejection.
authors.affiliation: Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Ciszek
authors.affiliation: Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Foroncewicz
authors.affiliation: Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Mucha
authors.affiliation: Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Żochowska
authors.affiliation: Department of Anatomic Pathology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.
authors.forename: Bogna
authors.initials: B
authors.lastname: Ziarkiewicz-Wróblewska
authors.affiliation: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Krawczyk
authors.affiliation: Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka Street 59, 02-006 Warsaw, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Pączek
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008107:Liver Diseases / Q000276:immunology / Q000401:mortality / Q000628:therapy; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; C099187:MHC class I-related chain A