title: Expression and prognostic significance of CIP2A in cutaneous malignant melanoma.
abstract: OBJECTIVE
  We investigated the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A (CIP2A) in Cutaneous malignant melanoma (CMM).
  
  
  METHODS
  CIP2A expression was analyzed by immunohistochemistry and western blot. We tested the invasion and migration capability of A375 cells with Matrigel invasion assay, Scratch migration assay and Matrigel migration assay after down-regulating CIP2A expression using siRNA.
  
  
  RESULTS
  CIP2A immunostaining level was correlated with Breslow thickness, Clark's Level and lymphovascular invasion. High-CIP2A expression implied poor survival for patients. Downregulation of CIP2A attenuated metastasis of CMM cells.
  
  
  CONCLUSIONS
  CIP2A may serve as a novel marker to predict the prognosis for CMM patients.
authors.affiliation: Department of Dermatology and Venereology, Nantong University , Nantong, Jiangsu , China .
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Yayun
authors.initials: Y
authors.lastname: Ding
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Ju
authors.forename: Xinhua
authors.initials: X
authors.lastname: Wu
authors.forename: Shuanglin
authors.initials: S
authors.lastname: Cao
mesh_terms: D001324:Autoantigens / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery
chemical_list: D001324:Autoantigens; D014408:Biomarkers, Tumor; C500266:CIP2A protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins