title: The effect of exogenous creatine phosphate on myocardial injury after percutaneous coronary intervention.
abstract: OBJECTIVE
  To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).
  
  
  METHODS
  Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3.
  
  
  RESULTS
  Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively).
  
  
  CONCLUSIONS
  Exogenous CP was helpful to reduce myocardial injury after PCI.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Deng
authors.initials: D
authors.lastname: Ke-Wu
authors.affiliation: Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Xu-Bo
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ying-Xin
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi-Wei
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China azzyj12@163.com.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yu-Jie
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Dong-Mei
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yu-Yang
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: De-An
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhe
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhi-Ming
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Hai-Long
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhen-Xian
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Chang-Sheng
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China; D052279:Creatine Kinase, MB Form / Q000097:blood; D019610:Cytoprotection; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010725:Phosphocreatine / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D019210:Troponin I; D010725:Phosphocreatine; D052279:Creatine Kinase, MB Form
keywords: creatine phosphate; myocardial injury; percutaneous coronary intervention