title: Endothelial cell targeted molecular imaging in tumor angiogenesis: strategies and current status.
abstract: Angiogenesis plays crucial roles in tumor growth, progression and metastasis. Non-invasive in vivo imaging of tumor neovasculature is a fundamental prerequisite for effective therapeutic intervention, particularly anti-angiogenic treatment regimens. Emerging molecular imaging techniques now allow recognition of cellular/molecular processes before gross pathological changes, leading to better understanding of fundamental biological processes of tumor angiogenesis. In this review, we will summarize recent progresses on molecular imaging of attractive biochemical epitopes in tumor angiogenesis, especially the endothelial cell targets-based imaging probes.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zeng
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China. gangliu.cmitm@xmu.edu.cn.
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A