title: [The endotoxine aggression in the pathogenesis of postoperative complications in children with Hirsprung disease].
abstract: Signs of disseminated intravascular clotting (DIC), which were considered the laboratory sign of the subcompensated endotoxine aggression, were detected in 20 children with the Hirsprung disease, aged 3 months - 11 years. Under the influence of the operation stress the subcompensated DIC transformed to the acute decompensated reaction, which led to early complications, such as anastomosistis with tendency to the insufficiency or stenosis, enterocolitis, etc. The study revealed not only the straight connection between the postoperative complications and endotoxine aggression, but the necessity of preoperative preparation, directed on the decrease of the intestinal endotoxin level and normalization of antiendotoxin immunity.
authors.forename: I V
authors.initials: IV
authors.lastname: Poddubnyĭ
authors.forename: M V
authors.initials: MV
authors.lastname: Meshkov
authors.forename: I A
authors.initials: IA
authors.lastname: Maĭskiĭ
authors.forename: O N
authors.initials: ON
authors.lastname: Nakovkin
authors.forename: S V
authors.initials: SV
authors.lastname: Kravchuk
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kozlov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Iakovlev
mesh_terms: D002648:Child; D002675:Child, Preschool; D019446:Endotoxemia / Q000097:blood / Q000209:etiology*; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006627:Hirschsprung Disease / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D013530:Surgical Wound Infection / Q000097:blood / Q000209:etiology*
chemical_list: D004731:Endotoxins