title: Construction of DNA-polymer hybrids using intercalation interactions.
abstract: Reversible addition-fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA-polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. Rachel.oreilly@warwick.ac.uk.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Wilks
authors.forename: Anaïs
authors.initials: A
authors.lastname: Pitto-Barry
authors.forename: Nigel
authors.initials: N
authors.lastname: Kirby
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
authors.forename: Rachel K
authors.initials: RK
authors.lastname: O'Reilly
mesh_terms: D000166:Acridines / Q000737:chemistry*; D000178:Acrylamides / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D009025:Morpholines / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: C527295:4-acryloylmorpholine; D000166:Acridines; D000178:Acrylamides; D000179:Acrylates; D007364:Intercalating Agents; D009025:Morpholines; D011108:Polymers; D004247:DNA; C099046:N,N-dimethylacrylamide; C067295:N-isopropylacrylamide