title: Food restriction increases long-term memory persistence in adult or aged mice.
abstract: Food restriction (FR) seems to be the unique experimental manipulation that leads to a remarkable increase in lifespan in rodents. Evidences have suggested that FR can enhance memory in distinct animal models mainly during aging. However, only few studies systemically evaluated the effects FR on memory formation in both adult (3-month-old) and aged (18-24-month-old) mice. Thus, the aim of the present study was to investigate the effects of acute (12h) or repeated (12h/day for 2days) FR protocols on learning and memory of adult and aged mice evaluated in the plus-maze discriminative avoidance task (PM-DAT), an animal model that concurrently (but independently) evaluates learning and memory, anxiety and locomotion. We also investigated the possible role of FR-induced stress by the corticosterone concentration in adult mice. Male mice were kept at home cage with food ad libitum (CTRL-control condition) or subjected to FR during the dark phase of the cycle for 12h/day or 12h/2days. The FR protocols were applied before training, immediately after it or before testing. Our results demonstrated that only FR for 2days enhanced memory persistence when applied before training in adults and before testing in aged mice. Conversely, FR for 2days impaired consolidation and exerted no effects on retrieval irrespective of age. These effects do not seem to be related to corticosterone concentration. Collectively, these results indicate that FR for 2days can promote promnestic effects not only in aged mice but also in adults.
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Talhati
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil. Electronic address: camila.patti@unifesp.br.
authors.forename: C L
authors.initials: CL
authors.lastname: Patti
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil; Departamento de Psicobiologia, Universidade Federal de São Paulo, R. Napoleão de Barros, 925, 04024002, São Paulo, SP, Brazil.
authors.forename: K A
authors.initials: KA
authors.lastname: Zanin
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil; Departamento de Psicobiologia, Universidade Federal de São Paulo, R. Napoleão de Barros, 925, 04024002, São Paulo, SP, Brazil.
authors.forename: L B
authors.initials: LB
authors.lastname: Lopes-Silva
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: L M B
authors.initials: LM
authors.lastname: Ceccon
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: A W
authors.initials: AW
authors.lastname: Hollais
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: Bizerra
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Santos
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, R. Napoleão de Barros, 925, 04024002, São Paulo, SP, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062, São Paulo, SP, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Frussa-Filho
mesh_terms: D000375:Aging / Q000097:blood / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001362:Avoidance Learning; D003345:Corticosterone / Q000097:blood; D005508:Food Deprivation; D008297:Male; D018782:Maze Learning; D057567:Memory, Long-Term; D011939:Mental Recall; D051379:Mice; D009043:Motor Activity
chemical_list: D003345:Corticosterone
keywords: Consolidation; Food deprivation; Learning; Mice; Retrieval