title: Evaluation of varying morphological parameters on the biomechanics of a cranial cruciate ligament-deficient or intact canine stifle joint with a computer simulation model.
abstract: OBJECTIVE
  To investigate the influence of varying morphological parameters on canine stifle joint biomechanics by use of a 3-D rigid-body canine pelvic limb computer model that simulated an intact and cranial cruciate ligament (CrCL)-deficient stifle joint across the stance phase of gait at a walk.
  
  
  METHODS
  Data from computer simulations.
  
  
  METHODS
  Computer model morphological parameters, including patellar ligament insertion location, tibial plateau angle (TPA), and femoral condyle diameter (FCD), were incrementally altered to determine their influence on outcome measures (ligament loads, relative tibial translation, and relative tibial rotation) during simulation of the stance phase of gait at a walk. Outcome measures were assessed for each scenario and compared between an intact and CrCL-deficient stifle joint with the sensitivity index (the percentage change in outcome measure divided by the percentage change in input parameter).
  
  
  RESULTS
  In a CrCL-intact stifle joint, ligament loads were most sensitive to TPA. In a CrCL-deficient stifle joint, outcome measures were most sensitive to TPA with the exception of caudal cruciate ligament and lateral collateral ligament loads, which were sensitive to FCD and TPA. Relative tibial translation was sensitive to TPA and patellar ligament insertion location, whereas relative tibial rotation was most sensitive to TPA.
  
  
  CONCLUSIONS
  The computer model sensitivity analyses predicted that individual parameters, particularly TPA and FCD, influence stifle joint biomechanics. Therefore, tibial and femoral morphological parameters may affect the likelihood, prevention, and management of CrCL deficiency.
authors.affiliation: Department of Bioengineering, J. B. Speed School of Engineering, University of Louisville, Louisville, KY 40202.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Brown
authors.forename: Gina E
authors.initials: GE
authors.lastname: Bertocci
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Marcellin-Little
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000033:anatomy & histology / Q000502:physiology; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D004285:Dogs / Q000033:anatomy & histology* / Q000502:physiology*; D005269:Femur / Q000033:anatomy & histology / Q000502:physiology; D005684:Gait; D008297:Male; D017847:Patellar Ligament / Q000033:anatomy & histology / Q000502:physiology; D012399:Rotation; D013264:Stifle / Q000033:anatomy & histology* / Q000502:physiology*; D013977:Tibia / Q000033:anatomy & histology / Q000502:physiology; D016138:Walking