title: Development of insulin loaded mesoporous silica injectable particles layered by chitosan as a controlled release delivery system.
abstract: The present work investigated the possibility of using mesoporous silica nanoparticles coated with low molecular weight chitosan as an injectable controlled release carrier of insulin. Insulin was totally encapsulated in particles. Surface tension measurements indicated that insulin was absorbed into mesoporous silica pores and interacted with chitosan. The stability of the encapsulated insulin was confirmed by different analytical methods such as RP-HPLC, FTIR and CD. Furthermore, the thermal stability using DSC was in the favor of the encapsulated insulin compared to free insulin. In vivo results indicated that insulin release was prolonged after loading into mesoporous silica nanoparticles. Such particles could be a potential carrier to control the release of insulin.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Saudi Arabia.
authors.forename: Amani
authors.initials: A
authors.lastname: Elsayed
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Saudi Arabia. Electronic address: mayyas@tu.edu.sa.
authors.forename: Mayyas
authors.initials: M
authors.lastname: Al-Remawi
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, Taif University, Saudi Arabia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Maghrabi
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hamaidi
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Saudi Arabia.
authors.forename: Nisrein
authors.initials: N
authors.lastname: Jaber
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D056148:Chromatography, Reverse-Phase / Q000379:methods; D002942:Circular Dichroism; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage*; D008970:Molecular Weight; D053758:Nanoparticles; D016062:Porosity; D011817:Rabbits; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007004:Hypoglycemic Agents; D007328:Insulin; D012822:Silicon Dioxide; D048271:Chitosan
keywords: Chitosan; Controlled release; Injectable; Insulin; Nanoparticles