title: Synthesis of some new flurbiprofen analogues as anti-inflammatory agents.
abstract: A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.
authors.forename: Laxmikant H
authors.initials: LH
authors.lastname: Nitlikar
authors.forename: Jaiprakash N
authors.initials: JN
authors.lastname: Sangshetti
authors.affiliation: Avra Laboratories Private Limited, Hyderabad 500076, A.P. India. lakikitu@gmail.com.
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005260:Female; D005480:Flurbiprofen / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D001393:Azoles; D011422:Propionates; D005480:Flurbiprofen