title: CD147: a novel modulator of inflammatory and immune disorders.
abstract: CD147, a transmembrane glycoprotein, is expressed on all leukocytes, platelets, and endothelial cells. It has been implicated in a variety of physiological and pathological activities through interacting with multiple partners, including cyclophilins, monocarboxylate transporters, Caveolin-1, and integrins. While CD147 is best known as a potent inducer of extracellular matrix metalloproteinases (hence also called EMMPRIN), it can also function as a key mediator of inflammatory and immune responses. Increased expression of CD147 has been implicated in the pathogenesis of a number of diseases, such as asthma-mediated lung inflammation, rheumatoid arthritis, multiple sclerosis, myocardial infarction and ischemic stroke. Therapeutic targeting of CD147 has yielded encouraging effects in a number of experimental models of human diseases, suggesting CD147 as an attractive target for treatment of inflammation-related diseases. Here we review the current understanding of CD147 expression and functions in inflammatory and immune responses and potential implications for treatment of inflammatory disorders.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: Z
authors.initials: Z
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Nanda
authors.affiliation: Vascular Biology & Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA. gli@lsuhsc.edu.
authors.forename: G
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D051926:Basigin / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology
chemical_list: D051926:Basigin