title: Therapeutic reduction mammoplasty in large-breasted women with cancer using superior and superomedial pedicles.
abstract: BACKGROUND
  Surgical management of breast cancer in large-breasted women presents a real challenge. This study aims to evaluate the outcome of therapeutic reduction mammoplasty in large-breasted women with breast cancer using superior and superomedial pedicles, situated at any breast quadrant except for the central and upper medial quadrants.
  
  
  METHODS
  Fifty women with breast cancer and large breasts underwent simultaneous bilateral reduction mammoplasty. The weight of the tissue removed ranged from 550 g to 1050 g and the tumor-free safety margins by frozen section were in the range of 4 cm to 12 cm.
  
  
  RESULTS
  The age of the patients ranged from 36 to 58 (median 43) years and tumor size ranged from 1 cm to 4 cm. The cosmetic outcomes were excellent in 32 patients (64%), good in 15 (30%) patients, and fair in three patients (6%). The follow-up period was 8-36 (mean 20) months, with no local recurrence or systemic metastasis.
  
  
  CONCLUSIONS
  Therapeutic reduction mammoplasty using superior and superomedial pedicles was shown to be oncologically safer than traditional conservative surgery. This oncoplastic procedure yields a satisfactory esthetic outcome with lower morbidity in large-breasted women with breast cancer.
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Adel
authors.initials: A
authors.lastname: Denewer
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Fayez
authors.initials: F
authors.lastname: Shahatto
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Waleed
authors.initials: W
authors.lastname: Elnahas
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Omar
authors.initials: O
authors.lastname: Farouk
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Sameh
authors.initials: S
authors.lastname: Roshdy
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Khater
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Osama
authors.initials: O
authors.lastname: Hussein
authors.affiliation: Clinical Oncology and Nuclear Medicine Department, Mansoura University, Mansoura, Egypt.
authors.forename: Saleh
authors.initials: S
authors.lastname: Teima
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hafez
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Samir
authors.initials: S
authors.lastname: Zidan
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Nazem
authors.initials: N
authors.lastname: Shams
authors.affiliation: Surgical Oncology Department, Oncology Center, Mansoura, Egypt.
authors.forename: Sherif
authors.initials: S
authors.lastname: Kotb
keywords: breast cancer; conservation surgery; oncoplastic surgery; reduction mammoplasty