title: Morphological alterations of epidermis of rabbits infested by R. sanguineus ticks and exposed to Selamectin (active principle of Pfizer Revolution(®) acaricide): a confocal microscopy study.
abstract: The present study analyzed, by means of confocal laser scanning microscopy, the epidermis of rabbits infested by the brown dog tick Rhipicephalus sanguineus and exposed to concentrations of 50%, 80% and 100% of a selamectin-based commercial acaricide (Pfizer's Revolution(®)). The results demonstrated that rabbits exposed to concentrations of 80% and 100% of the Revolution acaricide, which contains 12% selamectin, showed thinning of epithelial tissue of the epidermis with associated cellular disorganization. Individuals exposed to a 50% concentration showed lower epidermal tissue disorganization when compared to those exposed to the higher doses of the acaricide (80% and 100%). Whereas selamectin, when used in higher concentrations (80% and 100% Revolution(®)) can alter the morphology of the epidermis, at lower concentrations (50%), even though still able to eliminate ectoparasites, it causes less toxicity damage to the host. Selamectin can be considered a dose-dependent toxic agent, since higher concentrations increase the morphological changes in the epidermis of the host rabbits.
authors.affiliation: UNESP - São Paulo State University, Av. 24A, n. 1515, CP 199, CEP: 13506-900 Rio Claro, SP, Brazil.
authors.forename: Vlamir
authors.initials: V
authors.lastname: Bozzatto
authors.affiliation: UNESP - São Paulo State University, Av. 24A, n. 1515, CP 199, CEP: 13506-900 Rio Claro, SP, Brazil.
authors.forename: Patrícia Rosa de
authors.initials: PR
authors.lastname: Oliveira
authors.affiliation: UNESP - São Paulo State University, Via de acesso Prof. Paulo Castellane, s/n, 14884-900 Jaboticabal, SP, Brazil.
authors.forename: Gervásio Henrique
authors.initials: GH
authors.lastname: Bechara
authors.affiliation: UNESP - São Paulo State University, Av. 24A, n. 1515, CP 199, CEP: 13506-900 Rio Claro, SP, Brazil. Electronic address: micm@rc.unesp.br.
authors.forename: Maria Izabel
authors.initials: MI
authors.lastname: Camargo-Mathias
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004817:Epidermis / Q000187:drug effects / Q000469:parasitology / Q000473:pathology*; D004848:Epithelium; D005260:Female; D006790:Host-Parasite Interactions; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology; D018613:Microscopy, Confocal; D011817:Rabbits; D013987:Ticks / Q000187:drug effects / Q000502:physiology*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin
keywords: Acanthosis; Epidermis; Pathology; Rabbit; Selamectin; Ticks; Toxicology