title: Selective protein degradation: a rheostat to modulate cell-cycle phase transitions.
abstract: Plant growth control has become a major focus due to economic reasons and results from a balance of cell proliferation in meristems and cell elongation that occurs during differentiation. Research on plant cell proliferation over the last two decades has revealed that the basic cell-cycle machinery is conserved between human and plants, although specificities exist. While many regulatory circuits control each step of the cell cycle, the ubiquitin proteasome system (UPS) appears in fungi and metazoans as a major player. In particular, the UPS promotes irreversible proteolysis of a set of regulatory proteins absolutely required for cell-cycle phase transitions. Not unexpectedly, work over the last decade has brought the UPS to the forefront of plant cell-cycle research. In this review, we will summarize our knowledge of the function of the UPS in the mitotic cycle and in endoreduplication, and also in meiosis in higher plants.
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l'Université de Strasbourg, 67084 Strasbourg, France Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, Institut de Biologie Intégrative des Plantes 'Claude Grignon', UMR CNRS/INRA/SupAgro/UM2, Place Viala, 34060 Montpellier Cedex, France pascal.genschik@ibmp-cnrs.unistra.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Genschik
authors.affiliation: Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, Institut de Biologie Intégrative des Plantes 'Claude Grignon', UMR CNRS/INRA/SupAgro/UM2, Place Viala, 34060 Montpellier Cedex, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Marrocco
authors.affiliation: Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, Institut de Biologie Intégrative des Plantes 'Claude Grignon', UMR CNRS/INRA/SupAgro/UM2, Place Viala, 34060 Montpellier Cedex, France.
authors.forename: Lien
authors.initials: L
authors.lastname: Bach
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l'Université de Strasbourg, 67084 Strasbourg, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Noir
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l'Université de Strasbourg, 67084 Strasbourg, France.
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Criqui
mesh_terms: D002453:Cell Cycle; D063245:Plant Development; D010940:Plant Proteins / Q000378:metabolism*; D059748:Proteolysis
chemical_list: D010940:Plant Proteins
keywords: APC/C; DNA replication; SCF; cell cycle; cullin; endoreduplication; meiosis; mitosis; ubiquitin.