title: Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway.
abstract: As viruses do not possess genes encoding for proteins required for translation, energy metabolism or membrane biosynthesis, they are classified as obligatory intracellular parasites that depend on a host cell to replicate. This genome limitation forces them to gain control over cellular processes to ensure their successful propagation. A diverse spectrum of virally encoded proteins tackling a broad spectrum of cellular pathways during most steps of the viral life cycle ranging from the host cell entry to viral protein translation has evolved. Since the host cell PI3K/Akt signaling pathway plays a critical regulatory role in many cellular processes including RNA processing, translation, autophagy and apoptosis, many viruses, in widely varying ways, target it. This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication.
authors.forename: Nora
authors.initials: N
authors.lastname: Diehl
authors.affiliation: Universitätsklinikum Düsseldorf, Institut für Virologie, Universitätsstraße 1, Düsseldorf 40225, Germany. schaal@uni-duesseldorf.de.
authors.forename: Heiner
authors.initials: H
authors.lastname: Schaal
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D018406:Virus Physiological Phenomena
chemical_list: D064413:3-Phosphoinositide-Dependent Protein Kinases; D051057:Proto-Oncogene Proteins c-akt