title: Selective and sensitive superoxide detection with a new diselenide-based molecular probe in living breast cancer cells.
abstract: A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; (77)Se NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF-7/ADR cancer cells.
authors.affiliation: Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS) , 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: Sudesh T
authors.initials: ST
authors.lastname: Manjare
authors.forename: Sungsoo
authors.initials: S
authors.lastname: Kim
authors.forename: Won Do
authors.initials: WD
authors.lastname: Heo
authors.forename: David G
authors.initials: DG
authors.lastname: Churchill
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D015335:Molecular Probes; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013481:Superoxides / Q000032:analysis*; D014407:Tumor Cells, Cultured
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D015335:Molecular Probes; D016566:Organoselenium Compounds; D013481:Superoxides