title: Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 Peptide changes related to the body mass index.
abstract: This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m(2)); Group II (BMI 18.5-24.9 kg/m(2)); Group III (BMI 25-29.9 kg/m(2)); Group IV (BMI 30-39.9 kg/m(2)); Group V (BMI >40 kg/m(2)). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels increased with higher BMI, whereas desacylated ghrelin (DAG) decreased and nesfatin-1 showed no clear relationship to BMI.
authors.affiliation: Department of Endocrinology and Metabolism, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozkan
authors.affiliation: Department of Endocrinology and Metabolism, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Esra Suay
authors.initials: ES
authors.lastname: Timurkan
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey ; Department of Histology and Embryology, Medical School, Erzincan University, 24100 Erzincan, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sahin
authors.affiliation: Department of Endocrinology and Metabolism, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Timurkan
authors.affiliation: Atatürk Vocational School of Health Science, Kafkas University, 36040 Kars, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Citil
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kalayci
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey ; Department of Nutrition and Dietetic, Bitlis Eren University, 13000 Bitlis, Turkey.
authors.forename: Aziz
authors.initials: A
authors.lastname: Aksoy
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Firat University Hospital, 23119 Elazig, Turkey.
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Catak