title: Serum miR-200c and clinical outcome of patients with advanced esophageal squamous cancer receiving platinum-based chemotherapy.
abstract: MicroRNA-200c (miR-200c) influences sensitivity to chemotherapy and radiotherapy in vitro. This study was designed to investigate the prognostic potential of serum miR-200c in patients with advanced esophageal squamous cancer (ESCC). The serum levels of miR-200c was assayed by quantitative RT-PCR in 157 healthy subjects and 157 patients with advanced ESCC who were treated with platinum-based chemotherapy. The serum levels of miR-200c in advanced ESCC patients was significantly increased compared with those in controls (P < 0.001). Serum miR-200c expression was significantly associated with TNM stage (P = 0.037) and treatment response (P = 0.021). Patients with high expression of serum miR-200c had a higher risk for death than those with low expression of serum miR-200c (adjusted hazard ratios = 1.665, 95% confidence intervals: 1.135-2.443, P = 0.009). In conclusion, serum miR-200c may serve as predictor of survival for advanced ESCC and provide information for personalized therapy in advanced ESCC.
authors.affiliation: Department of Pathology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China.
authors.forename: Bensong
authors.initials: B
authors.lastname: Duan
authors.affiliation: Department of Anesthesiology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.affiliation: CMC Biobank and Translational Medicine Institute Taizhou, Jiangsu, China ; National Engineering Center for Biochip at Shanghai Shanghai, China ; Shanghai Engineering Center for Molecular Medicine Shanghai, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Junxing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China ; Shanghai Engineering Center for Molecular Medicine Shanghai, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
keywords: Esophageal squamous cancer; chemotherapy; miR-200c; microRNA; platinum