title: Airflow obstruction and left ventricular filling pressure in suspected chronic obstructive pulmonary disease.
abstract: Left ventricular (LV) filling impairment is present in patients with chronic obstructive pulmonary disease (COPD). Airflow obstruction is related to reduced LV end-diastolic volume, stroke volume, and cardiac output. The ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus (E/e'), an echocardiographic parameter, can be applied as a surrogate marker of LV filling pressures. Forty-seven individuals with suspected COPD underwent pulmonary function tests and echocardiography. The ratio of forced expiratory volume in 1s to forced vital capacity (FEV1/FVC) and the E/e' ratio were determined. Multivariate linear regression analysis showed that the FEV1/FVC ratio (β=0.01; 95% confidence interval, 0.001-0.019; p=0.036) independently predicted the log transformed E/e' ratio. An increase of FEV1/FVC ratio (in percentage) by 1 unit was associated with an increase of the E/e' ratio multiplied by 1.01. Airflow obstruction inversely predicts LV filling pressure in suspected COPD cases.
authors.affiliation: Department of Chest Medicine, En Chu Kong Hospital, Taiwan.
authors.forename: Yung-Huey
authors.initials: YH
authors.lastname: Yu
authors.affiliation: Department of Chest Medicine, En Chu Kong Hospital, Taiwan.
authors.forename: Ming-Zen
authors.initials: MZ
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine, En Chu Kong Hospital, Taiwan.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wen
authors.affiliation: Department of Cardiology, En Chu Kong Hospital, Taiwan.
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Chu
authors.affiliation: Department of Chest Medicine, En Chu Kong Hospital, Taiwan.
authors.forename: Chih-Teng
authors.initials: CT
authors.lastname: Chiang
authors.affiliation: Department of Chest Medicine, En Chu Kong Hospital, Taiwan.
authors.forename: Chung-Hua
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Cardiology, En Chu Kong Hospital, Taiwan. Electronic address: yuehjuhtw@yahoo.com.tw.
authors.forename: Yueh-Juh
authors.initials: YJ
authors.lastname: Lin
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D015150:Echocardiography, Doppler; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013318:Stroke Volume / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*; D014797:Vital Capacity
keywords: A; Airflow obstruction; COPD; E; E/A; E/e′; Echocardiography; FEV1; FEV1/FVC; FVC; GOLD; Global Initiative for Chronic Obstructive Lung Disease; LV; LVEF; Left ventricular filling pressure; SpO2; arterial oxygen saturation by pulse oximetry; chronic obstructive pulmonary disease; e′; forced expiratory volume in 1s; forced vital capacity; left ventricular; left ventricular ejection fraction; lnE/e′; peak early diastolic filling velocities of the mitral inflow; peak early diastolic velocity of the septal mitral annulus; peak late diastolic filling velocities of the mitral inflow; ratio of early to late peak diastolic filling velocities of the mitral inflow; ratio of forced expiratory volume in 1s to forced vital capacity; the log transformed ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus; the ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus