title: A case of hypomania during nicotine cessation treatment with bupropion.
abstract: Antidepressants can increase the spontaneous risk of hypomania or mania when used for treatment in affective disorders. When prescribed as an antidepressant, bupropion is generally considered to have a lower relative risk of inducing mood shifts. We describe the case of a 67-year-old man known for dysthymic disorder in remission on quetiapine and venlafaxine who experienced a first lifetime episode of hypomania with the introduction of bupropion SR for smoking cessation. To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient. This case highlights the need for clinicians who prescribe bupropion for smoking cessation to perform regular and systematic mood follow-ups during treatment. These follow-ups could even be more important when bupropion is selected to quit smoking in a patient already taking an antidepressant.
authors.forename: Karine
authors.initials: K
authors.lastname: Giasson-Gariépy
authors.affiliation: Research Center, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. didier.jutras-aswad@umontreal.ca.
authors.forename: Didier
authors.initials: D
authors.lastname: Jutras-Aswad
mesh_terms: D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced*; D016642:Bupropion / Q000009:adverse effects* / Q000627:therapeutic use; D019263:Dysthymic Disorder / Q000150:complications; D006801:Humans; D008297:Male; D016540:Smoking Cessation / Q000379:methods*; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion