title: Architecture of spatial circuits in the hippocampal region.
abstract: The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate network architecture within and between these unique circuits to functional outcome. Still, much is unknown about the mechanisms or network properties by which the functionally specific spatial firing profiles of neurons are generated, let alone how they are integrated into a coherently functioning meta-network. In this review, we explore the architecture of local networks and address how they may interact within the context of an overarching space circuit, aiming to provide directions for future successful explorations.
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, , 7030 Trondheim, Norway.
authors.forename: Menno P
authors.initials: MP
authors.lastname: Witter
authors.forename: Cathrin B
authors.initials: CB
authors.lastname: Canto
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Couey
authors.forename: Noriko
authors.initials: N
authors.lastname: Koganezawa
authors.forename: Kally C
authors.initials: KC
authors.lastname: O'Reilly
mesh_terms: D006624:Hippocampus / Q000033:anatomy & histology* / Q000166:cytology / Q000502:physiology; D006801:Humans; D009415:Nerve Net / Q000033:anatomy & histology* / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*
keywords: development; entorhinal cortex; hippocampus; parasubiculum; presubiculum