title: Microfluidic Valves Made From Polymerized Polyethylene Glycol Diacrylate.
abstract: Pneumatically actuated, non-elastomeric membrane valves fabricated from polymerized polyethylene glycol diacrylate (poly-PEGDA) have been characterized for temporal response, valve closure, and long-term durability. A ~100 ms valve opening time and a ~20 ms closure time offer valve operation as fast as 8 Hz with potential for further improvement. Comparison of circular and rectangular valve geometries indicates that the surface area for membrane interaction in the valve region is important for valve performance. After initial fabrication, the fluid pressure required to open a closed circular valve is ~50 kPa higher than the control pressure holding the valve closed. However, after ~1000 actuations to reconfigure polymer chains and increase elasticity in the membrane, the fluid pressure required to open a valve becomes the same as the control pressure holding the valve closed. After these initial conditioning actuations, poly-PEGDA valves show considerable robustness with no change in effective operation after 115,000 actuations. Such valves constructed from non-adsorptive poly-PEGDA could also find use as pumps, for application in small volume assays interfaced with biosensors or impedance detection, for example.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602.
authors.forename: Chad I
authors.initials: CI
authors.lastname: Rogers
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University, Provo, Utah 84602.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Oxborrow
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University, Provo, Utah 84602.
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Anderson
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University, Provo, Utah 84602.
authors.forename: Long-Fang
authors.initials: LF
authors.lastname: Tsai
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University, Provo, Utah 84602.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Nordin
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602.
authors.forename: Adam T
authors.initials: AT
authors.lastname: Woolley
keywords: membrane valve; non-adsorptive polymer; non-elastomeric polymer; pneumatic actuation; poly-PEGDA; valve characterization; valve response