title: Fractionated BNCT for locally recurrent head and neck cancer: experience from a phase I/II clinical trial at Tsing Hua Open-Pool Reactor.
abstract: To introduce our experience of treating locally and regionally recurrent head and neck cancer patients with BNCT at Tsing Hua Open-Pool Reactor in Taiwan, 12 patients (M/F=10/2, median age 55.5 Y/O) were enrolled and 11 received two fractions of treatment. Fractionated BNCT at 30-day interval with adaptive planning according to changed T/N ratios was feasible, effective and safe for selected recurrent head and neck cancer in this trial.
authors.affiliation: Cancer Center, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC. Electronic address: lwwang@vghtpe.gov.tw.
authors.forename: Ling-Wei
authors.initials: LW
authors.lastname: Wang
authors.affiliation: Cancer Center, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology, Taipei Veterans General Hospital, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Ching-Yin
authors.initials: CY
authors.lastname: Ho
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
authors.forename: Yen-Wan
authors.initials: YW
authors.lastname: Hsueh Liu
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC; Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: Fong-In
authors.initials: FI
authors.lastname: Chou
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: Yuan-Hao
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Liu
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: Jinn-Jer
authors.initials: JJ
authors.lastname: Peir
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
authors.forename: Shiang-Huei
authors.initials: SH
authors.lastname: Jiang
authors.affiliation: Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Chi-Wei
authors.initials: CW
authors.lastname: Chang
authors.affiliation: Cancer Center, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan, ROC; Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan, ROC.
authors.forename: Ching-Sheng
authors.initials: CS
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Shyh-Jen
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Taipei Veterans General Hospital, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Pen-Yuan
authors.initials: PY
authors.lastname: Chu
authors.affiliation: Cancer Center, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan, ROC; National Yang-Ming University, Taiwan, ROC.
authors.forename: Sang-Hue
authors.initials: SH
authors.lastname: Yen
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000009:adverse effects* / Q000379:methods*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Boron neutron capture therapy; Boronophenylalanine; Head and neck cancer; PET scan