title: Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
abstract: Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF- α ). Accumulating experimental evidence suggests that TNFR2 plays an important role in renal disorders associated with acute cellular rejection and clear cell renal carcinoma but its exact role in these settings is still not completely understood. This papers reviews the factors that may mediate TNFR2 induction in acute cellular rejection and clear cell renal carcinoma and its contribution to these conditions and discusses its therapeutic implications. A greater understanding of the function of TNFR2 may lead to the development of new anti-TNF drugs.
authors.affiliation: Department of Nephrology, First Hospital of China Medical University, Shenyang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medicine, Cambridge University NHS Trust Hospitals, Addenbrooke's Hospital, P.O. Box 157, Level 5, Hill's Road, Cambridge CB2 0QQ, UK.
authors.forename: Rafia S
authors.initials: RS
authors.lastname: Al-Lamki
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D006084:Graft Rejection / Q000378:metabolism*; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000378:metabolism*
chemical_list: D047889:Receptors, Tumor Necrosis Factor, Type II