title: [Pharmacokinetics of anesthesia related drugs in patients with chronic kidney disease].
abstract: For anesthetic management, various kinds of drugs are administered to the patient. When unchanged drugs or their active metabolites are eliminated from the kidney, renal function has significant effects on the pharmacokinetics of the drugs. Generally, in such cases, drug or metabolite clearance shows a positive relation with glomerular filtration rate. When these drugs are administered to patients with renal impairment, drug concentrations are increased, prolonging the pharmacological effects or causing side-effects. In anesthesia related drugs, morphine, muscle relaxants, antibiotics and phosphodiesterase III inhibitors require special attention. Their dosages should be adjusted according to parameters of renal function such as creatinine clearance.
authors.affiliation: Department of Anesthesiology, Postgraduate School of Medicine, Kanazawa University, Kanazawa 920-8641.
authors.forename: Tsunehisa
authors.initials: T
authors.lastname: Tsubokawa
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D000777:Anesthetics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001693:Biological Transport, Active; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D002352:Carrier Proteins / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004334:Drug Administration Schedule; D004734:Energy Metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008657:Metabolic Clearance Rate; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D011485:Protein Binding; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D016060:Sorption Detoxification
chemical_list: D000700:Analgesics; D000777:Anesthetics; D002317:Cardiovascular Agents; D002352:Carrier Proteins; D006993:Hypnotics and Sedatives; D009466:Neuromuscular Blocking Agents; D003577:Cytochrome P-450 Enzyme System