title: Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri.
abstract: Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 mL/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising L-NAME (40 mg/kg IV). In addition gastric mucus was removed by scraping and subsequently weighed. The experiment focused entirely on rats that had been subjected to fasting. The hydro-alcoholic extract of A. buettneri (500 mg/kg) significantly inhibited ulcers that were induced by ethanol, indomethacin or L-NAME pre-treatment. A. buettneri was shown to increase the production of gastric mucus. Furthermore L-arginine significantly decreased the size of the induced ulcers. The results achieved in the study carried out suggest that A. buettneri posses gastro-protective properties.
authors.affiliation: Medicinal Plants Research Center, Faculty of Science, University of Loma, Togo .
authors.forename: Kossi
authors.initials: K
authors.lastname: Metowogo
authors.affiliation: Medicinal Plants Research Center, Faculty of Science, University of Loma, Togo .
authors.forename: Kwashie
authors.initials: K
authors.lastname: Eklu-Gadegbeku
authors.affiliation: Medicinal Plants Research Center, Faculty of Science, University of Loma, Togo .
authors.forename: Amégnona
authors.initials: A
authors.lastname: Agbonon
authors.affiliation: Medicinal Plants Research Center, Faculty of Science, University of Loma, Togo .
authors.forename: Kodjo
authors.initials: K
authors.lastname: A Aklikokou
authors.affiliation: Medicinal Plants Research Center, Faculty of Science, University of Loma, Togo .
authors.forename: Messanvi
authors.initials: M
authors.lastname: Gbeassor
keywords: Aloe buettneri; Indomethacin; L-NAME; L-arginine; Ulcer