title: Hypovitaminosis D in patients with cystic fibrosis: a cross-section study in South Brazil.
abstract: BACKGROUND
  Cystic fibrosis (CF) patients have a susceptibility to vitamin D deficiency because of nutrient malabsorption.
  
  
  OBJECTIVE
  To evaluate the prevalence of hypovitaminosis D in CF patients and the factors associated with serum 25-hydroxyvitamin D levels.
  
  
  METHODS
  We evaluated the prevalence of vitamin D deficiency defined as 25-hydroxyvitamin D <30 ng/mL, as suggested recently by the Cystic Fibrosis Foundation, and factors associated with its serum levels. Patients with confirmed CF were included. Nutritional status and hospital admissions were evaluated. Serum C-reactive protein, calcium, phosphate, magnesium, albumin, 25-hydroxyvitamin D and parathyroid hormone levels were measured. Lung function was evaluated by spirometry, and clinical and chest radiographic scores were assessed. Statistical significance level was set at P < 0.05.
  
  
  RESULTS
  Fifty-nine patients were included. Prevalence of hypovitaminosis D was 61%. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with percentage of forced expiratory volume in 1 s predicted below 40%. After multivariate analysis, body mass index and hospitalization in the last month remained significantly associated with serum vitamin D levels.
  
  
  CONCLUSIONS
  Vitamin D insufficiency is still a problem in CF patients, even in those receiving supplementation.
authors.affiliation: Programa de Pós Graduação em Medicina, Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Natália Aydos
authors.initials: NA
authors.lastname: Marcondes
authors.forename: Fabiana Viegas
authors.initials: FV
authors.lastname: Raimundo
authors.forename: Roberta
authors.initials: R
authors.lastname: Vanacor
authors.forename: Bruno Pellini
authors.initials: BP
authors.lastname: Corte
authors.forename: Aline Maria
authors.initials: AM
authors.lastname: Ascoli
authors.forename: Aline Zimmermann
authors.initials: AZ
authors.lastname: de Azambuja
authors.forename: Luciano
authors.initials: L
authors.lastname: Scopel
authors.forename: Patrícia Vargas
authors.initials: PV
authors.lastname: Dos Santos
authors.forename: Paulo de Tarso Roth
authors.initials: Pde T
authors.lastname: Dalcin
authors.forename: Liane Nanci
authors.initials: LN
authors.lastname: Rotta
authors.forename: Tania Weber
authors.initials: TW
authors.lastname: Furlanetto
authors.forename: Gustavo Adolpho Moreira
authors.initials: GA
authors.lastname: Faulhaber
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001938:Brazil; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; cystic fibrosis; nutrition; pulmonary function; vitamin D deficiency