title: Addition of haptoglobin to RBCs storage, a new strategy to improve quality of stored RBCs and transfusion.
abstract: Transfusion of red blood cells (RBCs) is an effective therapy in surgery and critical care. Comparing to fresh RBCs, the therapeutic effect of stored RBCs is greatly limited because of its loss of NO during storage, which leads to vasodilatation dysfunction upon transfusion. So far, there is no effective solution to this problem. Here, we summarize the protective effects of Haptoglobin (Hp) in RBCs storage and transfusion, by using data extracted from literature review. Because Free Hemoglobin (FHb) is the major factor responsible for rapid NO loss during storage, addition of FHb-sequestering protein Haptoglobin will prevent the loss of NO and improve the quality of stored RBCs.
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27 Taiping Road, HaiDian, Beijing 100850, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27 Taiping Road, HaiDian, Beijing 100850, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27 Taiping Road, HaiDian, Beijing 100850, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27 Taiping Road, HaiDian, Beijing 100850, China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Blood Transfusion, Affiliated Hospital of Academy of Military Medical Sciences, No. 8 Dongda Street, FengTai, Beijing 100071, China. Electronic address: 13691110351@163.com.
authors.forename: Quanli
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27 Taiping Road, HaiDian, Beijing 100850, China. Electronic address: zhouhtt1966@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001793:Blood Preservation / Q000379:methods*; D017707:Erythrocyte Transfusion / Q000379:methods*; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D006242:Haptoglobins / Q000737:chemistry*; D006801:Humans; D008962:Models, Theoretical; D009569:Nitric Oxide / Q000737:chemistry; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry
chemical_list: D006242:Haptoglobins; D009569:Nitric Oxide; D010100:Oxygen