title: Isolation of major components from the roots of Godmania aesculifolia and determination of their antifungal activities.
abstract: From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
authors.affiliation: Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica.
authors.forename: Giselle
authors.initials: G
authors.lastname: Tamayo-Castillo
authors.affiliation: Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica.
authors.forename: Víctor
authors.initials: V
authors.lastname: Vásquez
authors.affiliation: Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Ríos
authors.affiliation: Farmacognosia y Biología Vegetal, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Rodríguez
authors.affiliation: Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica.
authors.forename: Godofredo
authors.initials: G
authors.lastname: Solano
authors.affiliation: Farmacognosia y Biología Vegetal, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.affiliation: Centro de Investigaciones Farmacognósticas de la Flora Panameña, CIFLORPAN, Universidad de Panamá, Panamá, Panamá
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
mesh_terms: D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D029402:Bignoniaceae / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000935:Antifungal Agents; D006027:Glycosides; D009285:Naphthoquinones; D010936:Plant Extracts; C007633:estragole; C008252:lapachol