title: A meta-analysis that compares the use of either peginterferon-α2a or peginterferon-α2b plus ribavirin for HCV infection.
abstract: BACKGROUND
  Two kinds of peginterferons, peginterferon-α2a (PEG-IFN-α2a) and peginterferon-α2b (PEG-IFN-α2b), are used in the treatment of chronic hepatitis C virus (HCV) infection. However, it is unclear which is better in terms of virological responses and patient compliance. We conducted a meta-analysis to assess which peginterferon was better when used with ribavirin.
  
  
  METHODS
  Relevant clinical trials were identified through the PubMed and EMBASE databases. Primary outcomes included early virological response (EVR), end of treatment response (ETR) and sustained virological response (SVR). Secondary outcomes included biochemical and histological responses and the discontinuation of treatment after adverse events. Meta-analysis was performed using fixed-effect or random-effect methods, depending on absence or presence of significant heterogeneity. Analyses were performed with Review Manager Version 4.2.2.
  
  
  RESULTS
  Seven clinical trials were included that involved 3,526 patients in total; six were randomized clinical trials (RCTs) and one was nonrandomized. PEG-IFN-α2a plus ribavirin was better than PEG-IFN-α2b plus ribavirin with regards to ETR (relative risk [RR] = 1.21, 95% confidence interval [CI]: 1.14-1.28). This advantage was less obvious for EVR (RR = 1.12, 95% CI: 1.06-1.19) and SVR (RR = 1.10, 95% CI: 1.02-1.18). Patients who received PEG-IFN-α2a were less likely to discontinue treatment for safety reasons (RR = 0.85, 95% CI: 0.52-1.38).
  
  
  CONCLUSIONS
  We demonstrated that PEG-IFN-α2a was a better choice than PEG-IFN-α2b in terms of virological responses.
authors.affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Xiao
authors.affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
keywords: chronic hepatitis C virus (HCV) infection; peginterferon-α2a (PEG-IFN-α2a); peginterferon-α2b (PEG-IFN-α2b); ribavirin; treatment