title: What are the intracellular targets and intratissue target cells for radiation effects?
abstract: Exactly a century after Röntgen's discovery of X rays, I entered a university to major in radiological sciences. At that time, I felt that, despite extensive use and indispensable roles of ionizing radiation in medicine and industry, many fascinating questions have yet to be answered concerning its biological mechanisms of action, and thus I decided to get into the field of radiation research. Fifteen years have passed since I started radiobiological studies in 1998, during which time various basic tenets I initially learned in my late teens and early twenties have been challenged by recent observations. Of these, this brief overview particularly focuses on the following five different albeit non mutually exclusive questions: (i) "Is nuclear DNA the only intracellular target for radiation effects?"; (ii) "What is the significance of delayed cell death in clonogenic survival?"; (iii) "Does an irradiated cell become a cancer cell?"; (iv) "Are cataracts tissue reactions?"; and (v) "Why is high-LET radiation biologically effective?".
authors.affiliation: Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Tokyo, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamada
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D063646:Carcinogenesis / Q000528:radiation effects; D016923:Cell Death / Q000528:radiation effects; D002467:Cell Nucleus / Q000235:genetics / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000235:genetics; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism / Q000528:radiation effects*; D018499:Linear Energy Transfer; D011853:Radiobiology
chemical_list: D004247:DNA