title: Pathological gambling induced by dopamine antagonists: a case report.
abstract: Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour. It is a non-pharmacological addiction classified as an impulse control disorder. However, pathological gambling has been associated with dopamine agonist use. Here we report of a 28-year-old man with a first major depressive episode and a post-traumatic stress disorder who has been treated with a combination of the serotonine/noradrenaline reuptake inhibitor duloxetine and the tricyclic antidepressant maprotiline. The administration of antipsychotic flupentixole (up to 7 mg) turned this slight online poker gambler into an excessive gambler. Only after the discontinuation of the antidopaminergic agents and the switch to bupropion did this gambling behaviour stop which suggests a causal relationship between dopamine antagonists and pathological gambling.
authors.affiliation: Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4012, Basel, Switzerland.
authors.forename: Philipp
authors.initials: P
authors.lastname: Grötsch
authors.forename: Claudia
authors.initials: C
authors.lastname: Lange
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Wiesbeck
authors.forename: Undine
authors.initials: U
authors.lastname: Lang
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000139:chemically induced* / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D005475:Flupenthixol / Q000008:administration & dosage / Q000009:adverse effects*; D005715:Gambling / Q000139:chemically induced* / Q000523:psychology; D006801:Humans; D008297:Male; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000188:drug therapy
chemical_list: D018492:Dopamine Antagonists; D005475:Flupenthixol