title: Streptococcus pneumoniae serotype distribution in children in the Russian Federation before the introduction of pneumococcal conjugate vaccines into the National Immunization Program.
abstract: WHO recommends the inclusion of PCVs in childhood vaccination programs world-wide. Many countries including the Russian Federation are currently planning the inclusion of PCVs in their National Immunization Programs and, therefore, data on the pneumococcal serotype distribution is important to estimate the potential disease impact. Here we review eight recent epidemiological studies on the pneumococcal serotype distribution from Russia. Across all studies, serotypes 6B, 14, 19F and 23F were the most prevalent. Interestingly, serotype 3 was relatively common. Serotype 19A was prevalent among AOM, CAP and nasopharyngeal isolates and among antibiotic resistant isolates in all age groups. The differences in serotype coverage between PCV10 and PCV13 were up to 26%. Based on the current data on serotype distribution, a wide use of PCVs in Russia may lead to a significant reduction of the pneumococcal disease burden.
authors.affiliation: Scientific Center of Children Health, Russian Academy of Medical Science, 2/62, Lomonosovskiy avenue, Moscow, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tatochenko
authors.forename: Sergey
authors.initials: S
authors.lastname: Sidorenko
authors.forename: Leila
authors.initials: L
authors.lastname: Namazova-Baranova
authors.forename: Nikolay
authors.initials: N
authors.lastname: Mayanskiy
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kulichenko
authors.forename: Alexander
authors.initials: A
authors.lastname: Baranov
authors.forename: Yury
authors.initials: Y
authors.lastname: Lobzin
authors.forename: Susanna
authors.initials: S
authors.lastname: Kharit
authors.forename: Roman
authors.initials: R
authors.lastname: Kozlov
authors.forename: Irina
authors.initials: I
authors.lastname: Andreeva
authors.forename: Alexander
authors.initials: A
authors.lastname: Muravjev
authors.forename: Aida
authors.initials: A
authors.lastname: Chagaryan
authors.forename: Irina
authors.initials: I
authors.lastname: Koroleva
authors.forename: Grigoriy
authors.initials: G
authors.lastname: Beloshitskiy
authors.forename: Konstantin
authors.initials: K
authors.lastname: Mironov
authors.forename: Elena
authors.initials: E
authors.lastname: Degtyareva
authors.forename: Ralf René
authors.initials: RR
authors.lastname: Reinert
mesh_terms: D000293:Adolescent; D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D006291:Health Policy; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D007231:Infant, Newborn; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D015995:Prevalence; D012426:Russia / Q000453:epidemiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000302:isolation & purification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate