title: Extramedullary blast crisis of chronic myelogenous leukemia as an initial presentation.
abstract: Extramedullary blast crisis of chronic myelogenous leukemia (CML) is defined as the development of extramedullary disease caused by the infiltration of blasts regardless of proliferation of blasts in the bone marrow. The onset of extramedullary blast crisis in the newly diagnosed patients is known to be extremely rare. Here, we present a case of extramedullary blast crisis of CML as an initial presentation in a 17-year-old female presenting with pain in the left femur tumor. This case was treated successfully with dasatinib and allogeneic hematopoietic stem cell transplantation, with achievement of long-term remission.
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Shokichi
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Pathology, Chiba University Hospital, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan ; Division of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.affiliation: Division of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
keywords: Chronic myelogenous leukemia (CML); Dasatinib; Extramedullary blast crisis