title: Frequency of various types of neoplasia in a group of acromegalic patients.
abstract: OBJECTIVE
  To determine the frequency of colon cancer, primary hyperparathyroidism, thyroid tumor, and skin cancer in all acromegalic patients in follow-up at the Clinics Hospital - Botucatu Medical School, from 2005 to 2011.
  
  
  METHODS
  These patients were evaluated retrospectively for colon cancer, primary hyperparathyroidism, dermatological, and thyroid tumors.
  
  
  RESULTS
  Of 29 patients included at the beginning of the study, two were excluded. Among 19 patients submitted to colonoscopy, one presented colon adenocarcinoma (5%). Thyroid nodules were present in 63% of patients, and papilliferous carcinoma was confirmed in two patients (7,7%). Four patients were confirmed as having primary hyperparathyroidism (15%). The most common dermatologic lesions were thickened skin (100%), acrochordons (64%), epidermal cysts (50%), and pseudo-acanthosis nigricans (50%). Only one patient presented basal cell carcinoma.
  
  
  CONCLUSIONS
  Although a small number of acromegalic patients was studied, our findings confirm the high frequency of thyroid neoplasias and primary hyperparathyroidism in this group of patients.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Bolfi
authors.forename: Helio Amante
authors.initials: HA
authors.lastname: Miot
authors.forename: Mariangela
authors.initials: M
authors.lastname: Resende
authors.forename: Glaucia M S F
authors.initials: GM
authors.lastname: Mazeto
authors.forename: Fernando Gomes
authors.initials: FG
authors.lastname: Romeiro
authors.forename: Fábio da Silva
authors.initials: Fda S
authors.lastname: Yamashiro
authors.forename: Vânia dos Santos
authors.initials: Vdos S
authors.lastname: Nunes
mesh_terms: D000052:Acanthosis Nigricans / Q000175:diagnosis; D000172:Acromegaly / Q000097:blood / Q000150:complications*; D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis / Q000453:epidemiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D016606:Thyroid Nodule / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D007334:Insulin-Like Growth Factor I