title: Immunohistochemical analysis of P63 expression in odontogenic lesions.
abstract: P63 may have a role in tumorigenesis and cytodifferentiation of odontogenic lesions. We investigated the immunohistochemical expression of P63 in a total of 30 cases of odontogenic cysts and tumors. The percentage of positive cells was calculated in the lining of odontogenic cysts and islands of ameloblastoma. P63 expression was evident in all types of odontogenic lesions. P63 was expressed throughout the lining epithelium of odontogenic keratocyst except surface parakeratinized layer. In addition, calcifying odontogenic cyst showed P63 expression in all layers. In almost all radicular and dentigerous cysts, the basal and parabasal layers were immunoreactive. Peripheral cells of ameloblastoma expressed P63; however, stellate reticulum had weaker immunostaining. No significant difference in P63 expression was observed between studied lesions (P = 0.86). Expression of P63 in odontogenic lesions suggests that this protein is important in differentiation and proliferation of odontogenic epithelial cells. However, it seems that it could not be a useful marker to differentiate between aggressive and nonaggressive lesions. P63 also represents a progenitor or basal cell marker, and it is not expressed in mature differentiated cells.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Saede
authors.initials: S
authors.lastname: Atarbashi Moghadam
authors.affiliation: Department of Periodontology, Dental School of Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Fazele
authors.initials: F
authors.lastname: Atarbashi Moghadam
authors.affiliation: Department of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Mokhtari
authors.affiliation: Research Committee, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Eini
mesh_terms: D000564:Ameloblastoma / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D009807:Odontogenic Cysts / Q000235:genetics / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C081876:CKAP4 protein, human; D008565:Membrane Proteins