title: Phenindione interference in enzymatic creatinine assay - A case report.
abstract: Enzymatic creatinine assays are considered superior to Jaffe assays due to greater analytical specificity. We report a case of phenindione interference with an enzymatic assay resulting in significant misclassification in a patient with chronic kidney disease (CKD). Analysis of creatinine values of a further 36 patients who were treated with phenindione showed significant negative interference of phenindione with the Roche enzymatic creatinine assay.
authors.forename: Balan
authors.initials: B
authors.lastname: Natarajan
authors.forename: Tanya
authors.initials: T
authors.lastname: Hart
authors.forename: Sophy
authors.initials: S
authors.lastname: Smith
authors.forename: Robin Geoffrey
authors.initials: RG
authors.lastname: Parry
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D003404:Creatinine / Q000097:blood*; D003951:Diagnostic Errors; D057075:Enzyme Assays / Q000379:methods*; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010630:Phenindione / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; D010630:Phenindione; D003404:Creatinine