title: Positive association of coronary calcium detected by computed tomography coronary angiography with periprocedural myocardial infarction.
abstract: BACKGROUND
  Periprocedural myocardial infarction (PMI) may occur in approximately 5% to 30% of patients undergoing percutaneous coronary intervention. Whether the morphology of coronary plaque calcium affects the occurrence of PMI is unknown.
  
  
  METHODS
  A total of 616 subjects with stable angina and normal baseline cardiac troponin I levels who had undergone computed tomography angiography (CTA) were referred to elective percutaneous coronary intervention. The morphology of coronary calcium was determined by CTA analysis. PMI was defined as an elevation in 24-h post-procedural cardiac troponin I levels of > 5 times the upper limit of normal with either symptoms of myocardial ischemia, new ischemic electrocardiographic changes, or documented complications during the procedure. Logistic regression was performed to identify the effect of the morphology of coronary calcium on the occurrence of PMI.
  
  
  RESULTS
  According to the presence or morphology of coronary calcium as shown by CTA, 210 subjects were grouped in the heavy calcification group, 258 in the mild calcification group, 40 in the spotty calcification group and 108 in the control group. The dissection rate was significantly higher in the heavy calcification group than in the control group (7.1 % vs. 1.9%, p = 0.03). The occurrence of PMI in the heavy calcification group was significantly higher than that in the control group (OR 4.38, 95% CI 1.80-10.65, p = 0.001). After multivariate adjustment, the risk of PMI still remained significantly higher in the heavy calcification group than in the control group (OR 4.04, 95% CI 1.50-10.89, p = 0.003).
  
  
  CONCLUSIONS
  The morphology of coronary calcium determined by CTA may help to predict the subsequent occurrence of PMI. A large amount of coronary calcium may be predictive of PMI.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Beijing Institute of Heart, Lung and Blood Vessel Diseases and The Key Laboratory of Remodeling- related Cardiovascular Disease, Ministry of Education, Beijing, China.
authors.forename: Xuxia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Ge
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China ; Beijing Institute of Heart, Lung and Blood Vessel Diseases and The Key Laboratory of Remodeling- related Cardiovascular Disease, Ministry of Education, Beijing, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery*; D002118:Calcium / Q000378:metabolism; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods / Q000706:statistics & numerical data; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D062645:Percutaneous Coronary Intervention; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology
chemical_list: D002118:Calcium