title: Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides.
abstract: The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
authors.affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester, M13 9PL, U.K.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Pace
authors.forename: James P
authors.initials: JP
authors.lastname: Rae
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter