title: Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
abstract: Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA. ; Tel: 1-(808)-933-2960.
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
authors.forename: Thirunavukkarasu
authors.initials: T
authors.lastname: Annamalai
authors.affiliation: Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Bansod
authors.affiliation: Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
authors.forename: Yuk-Ching
authors.initials: YC
authors.lastname: Tse-Dinh
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA. ; Tel: 1-(808)-933-2960.
authors.forename: Dianqing
authors.initials: D
authors.lastname: Sun