title: Levofloxacin and furazolidone induced toxic epidermal necrosis.
abstract: Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a severe cutaneous drug reaction with a high mortality. Immune response is the possible cause in its pathogenesis. Levofloxacin is one of the most commonly used quinolones and has been reported to cause of TEN. On the other hand, furazolidone was proposed to augment the action of immediate hypersensitivity of levofloxacin by its cytotoxic effect and by the generation of free radicals. Here, we present a case of TEN where, levofloxacin and furazolidone were the probable cause of these adverse drug reactions.
authors.affiliation: Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Varma
authors.affiliation: Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
authors.forename: Shanta
authors.initials: S
authors.lastname: Sutradhar
authors.affiliation: Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
authors.forename: Arup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005664:Furazolidone / Q000009:adverse effects*; D006801:Humans; D064704:Levofloxacin / Q000009:adverse effects*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000890:Anti-Infective Agents; D005664:Furazolidone; D064704:Levofloxacin; D003907:Dexamethasone
keywords: Cytotoxicity; furazolidone; hypersensitivity reaction; levofloxacin; toxic epidermal necrolysis