title: An endoscopic-assisted technique for retrosellar access during the extended retrosigmoid approach: a cadaveric feasibility study and quantitative analysis of retrosellar working area.
abstract: The retrosigmoid approach has been advocated for certain petroclival tumors but provides limited access to any retrosellar extension of tumor, necessitating a two-stage operation. Our purpose was to demonstrate preliminary feasibility of an endoscopic-assisted technique to provide retrosellar access during the extended retrosigmoid approach and compare microscopic and endoscopic retrosellar working area. Standard retrosigmoid craniectomy and partial petrosectomy respecting inner ear structures were performed on six embalmed cadaveric heads. Two balloons were inflated to simulate a 15 mm petroclival tumor. Retrosellar clival and brainstem working area and ipsilateral oculomotor nerve and posterior cerebral artery (PCA) working distance were measured using the endoscope and microscope. Artificial tumors were implanted and resected using the endoscopic-assisted technique to assess feasibility. The endoscope provided significantly greater mean working area/distance on the clivus (201.6 vs 114.8 mm(2), p < 0.01), brainstem (223.5 vs 121.2 mm(2), p < 0.01), ipsilateral oculomotor nerve (10.8 vs 6.4 mm, p < 0.01), and ipsilateral PCA (13.7 vs 8.9 mm, p = 0.01). Petrous dissection to create a 10 × 10 mm working channel and artificial tumor resection was feasible in all dissections. The superior petrosal vein required ligation in 9 (75%) cases. Air cells were exposed in 1 (8%) case. The described endoscopic-assisted technique can provide retrosellar access during the extended retrosigmoid approach to access petroclival tumors with retrosellar extension. Risks include superior petrosal vein sacrifice, bleeding that can impair visualization, injury to the trigeminal nerve during endoscopic insertion/manipulation or injury to the brainstem while working in the medial limits of exposure. Further work is necessary to determine clinical feasibility, safety, and efficacy.
authors.affiliation: Dardinger Microneurosurgical Skull Base Laboratory, Department of Neurological Surgery, Ohio State University Medical Center, N1025 Doan Hall, 410W. 10th Avenue, Columbus, OH, 43210, USA.
authors.forename: Varun R
authors.initials: VR
authors.lastname: Kshettry
authors.forename: Silky
authors.initials: S
authors.lastname: Chotai
authors.forename: William
authors.initials: W
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Mario
authors.initials: M
authors.lastname: Ammirati
mesh_terms: D001933:Brain Stem / Q000473:pathology / Q000601:surgery; D002102:Cadaver; D002530:Cerebellopontine Angle / Q000473:pathology* / Q000601:surgery; D003388:Cranial Fossa, Posterior / Q000473:pathology* / Q000601:surgery; D004210:Dissection / Q000379:methods; D005240:Feasibility Studies; D006801:Humans; D044583:Neuroendoscopy; D010579:Petrous Bone / Q000473:pathology* / Q000601:surgery; D014276:Trigeminal Nerve / Q000473:pathology* / Q000601:surgery