title: Structural brain differences in school-age children with residual speech sound errors.
abstract: The purpose of the study was to identify structural brain differences in school-age children with residual speech sound errors. Voxel based morphometry was used to compare gray and white matter volumes for 23 children with speech sound errors, ages 8;6-11;11, and 54 typically speaking children matched on age, oral language, and IQ. We hypothesized that regions associated with production and perception of speech sounds would differ between groups. Results indicated greater gray matter volumes for the speech sound error group relative to typically speaking controls in bilateral superior temporal gyrus. There was greater white matter volume in the corpus callosum for the speech sound error group, but less white matter volume in right lateral occipital gyrus. Results may indicate delays in neuronal pruning in critical speech regions or differences in the development of networks for speech perception and production.
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Department of Communication Disorders, Southern Connecticut State University, New Haven, CT, United States. Electronic address: preston@haskins.yale.edu.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Preston
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Molfese
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States.
authors.forename: W Einar
authors.initials: WE
authors.lastname: Mencl
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Frost
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Department of Psychiatry, University of California San Francisco, San Francisco, CA, United States.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Hoeft
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Fulbright
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Yale Child Study Center, New Haven, CT, United States.
authors.forename: Nicole
authors.initials: N
authors.lastname: Landi
authors.affiliation: Yale Child Study Center, New Haven, CT, United States.
authors.forename: Elena L
authors.initials: EL
authors.lastname: Grigorenko
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Tottori University, Tottori, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Seki
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Felsenfeld
authors.affiliation: Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, United States; Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States; University of Connecticut, Department of Psychology, Storrs, CT, United States; Department of Linguistics, Yale University, New Haven, CT, United States.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Pugh
mesh_terms: D001921:Brain / Q000473:pathology*; D002648:Child; D006801:Humans; D007805:Language Development Disorders / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010700:Phonetics; D013067:Speech Perception
keywords: Children; Speech sound disorders; Speech sound errors; Structural MRI