title: Physiology in medicine: acute altitude exposure in patients with pulmonary and cardiovascular disease.
abstract: Travel is more affordable and improved high-altitude airports, railways, and roads allow rapid access to altitude destinations without acclimatization. The physiology of exposure to altitude has been extensively described in healthy individuals; however, there is a paucity of data pertaining to those who have reduced reserve. This Physiology in Medicine article discusses the physiological considerations relevant to the safe travel to altitude and by commercial aircraft in patients with pulmonary and/or cardiac disease.
authors.affiliation: Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.
authors.forename: Leigh M
authors.initials: LM
authors.lastname: Seccombe
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Peters
mesh_terms: D000064:Acclimatization / Q000502:physiology; D000399:Air Pressure; D000531:Altitude; D000532:Altitude Sickness / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology*; D010102:Oxygen Inhalation Therapy; D014195:Travel
keywords: altitude; cardiovascular disease; hypobaric hypoxia; pulmonary disease