title: Oxidative stress and antioxidant activity in hypothermia and rewarming: can RONS modulate the beneficial effects of therapeutic hypothermia?
abstract: Hypothermia is a condition in which core temperature drops below the level necessary to maintain bodily functions. The decrease in temperature may disrupt some physiological systems of the body, including alterations in microcirculation and reduction of oxygen supply to tissues. The lack of oxygen can induce the generation of reactive oxygen and nitrogen free radicals (RONS), followed by oxidative stress, and finally, apoptosis and/or necrosis. Furthermore, since the hypothermia is inevitably followed by a rewarming process, we should also consider its effects. Despite hypothermia and rewarming inducing injury, many benefits of hypothermia have been demonstrated when used to preserve brain, cardiac, hepatic, and intestinal function against ischemic injury. This review gives an overview of the effects of hypothermia and rewarming on the oxidant/antioxidant balance and provides hypothesis for the role of reactive oxygen species in therapeutic hypothermia.
authors.affiliation: Departament de Fisiologia i Immunologia, Universitat de Barcelona, Avenida Diagonal 643, 08028 Barcelona, Spain.
authors.forename: Norma
authors.initials: N
authors.lastname: Alva
authors.affiliation: Departament de Fisiologia i Immunologia, Universitat de Barcelona, Avenida Diagonal 643, 08028 Barcelona, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Palomeque
authors.affiliation: Departament de Fisiologia i Immunologia, Universitat de Barcelona, Avenida Diagonal 643, 08028 Barcelona, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Carbonell
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D007036:Hypothermia, Induced; D018384:Oxidative Stress / Q000187:drug effects*; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017694:Rewarming
chemical_list: D000975:Antioxidants; D026361:Reactive Nitrogen Species