title: Clinical predictors of long-term outcomes in patients with critical limb ischemia who have undergone endovascular therapy.
abstract: Clinical predictors of long-term outcomes in patients with critical limb ischemia (CLI) treated with endovascular therapy (EVT) remain unclear. In this study, clinical predictors of long-term outcomes in EVT-treated patients with CLI were investigated. In this prospective, observational study, we analyzed a total of 253 Taiwanese patients with CLI with 314 limbs who underwent EVT between 2005 and 2012. Cox models were used to estimate hazard ratios of death, limb loss, and sustained clinical success (SCS). Multivariate analysis showed that age, atrial fibrillation (AF), end-stage renal disease (ESRD), and albumin were significant predictors of mortality. Patients with coronary artery disease and low albumin levels had a significant risk of major limb amputation, while AF, ESRD, and albumin were significant, independent predictors of SCS. In addition to previously reported predictors, we showed that AF and malnutrition can be used to predict long-term outcome in EVT-treated patients with CLI.
authors.affiliation: 1Section of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Shang-Hung
authors.initials: SH
authors.lastname: Chang
authors.forename: Yueh-Ju
authors.initials: YJ
authors.lastname: Tsai
authors.forename: Hsin-Hua
authors.initials: HH
authors.lastname: Chou
authors.forename: Tien-Yu
authors.initials: TY
authors.lastname: Wu
authors.forename: Chien-An
authors.initials: CA
authors.lastname: Hsieh
authors.forename: Shih-Tsung
authors.initials: ST
authors.lastname: Cheng
authors.forename: Hsuan-Li
authors.initials: HL
authors.lastname: Huang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D001281:Atrial Fibrillation / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000401:mortality; D016638:Critical Illness; D018572:Disease-Free Survival; D057510:Endovascular Procedures / Q000009:adverse effects / Q000401:mortality; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000401:mortality; D023821:Limb Salvage; D008297:Male; D044342:Malnutrition / Q000401:mortality; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C422455:ALB protein, human; D015415:Biomarkers; D012709:Serum Albumin; D000075462:Serum Albumin, Human
keywords: critical limb ischemia; endovascular therapy; nutrition; predictors; prognosis