title: The role of anionic peptide fragments in 1N4R human tau protein aggregation.
abstract: Cellular protein degradation systems are necessary to avoid the accumulation of misfolded or damaged proteins. Deficiency in these systems might cause to partial degradation of misfolded proteins and generation of amyloidogenic fragments. Protein misfolding is believed to be the primary cause of neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we investigate effect of two anionic peptide fragments including, an acidic fragment of human Aβ (Aβ1-11) and a phosphorylated fragment of β-Casein (Tetraphosphopeptide), on tau protein aggregation. According to our results, these peptide fragments, induced tau fibrillization in vitro. In sum, we suggest that structural and conformational characters of inducer are as important as charge distribution on anionic inducer molecules however more experiments would be need to exactly confirm this suggestion.
authors.forename: Mohammad Ali Nasiri
authors.initials: MA
authors.lastname: Khalili
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Riazi
authors.forename: Shahin
authors.initials: S
authors.lastname: Ahmadian
authors.forename: Reza
authors.initials: R
authors.lastname: Khodarahmi
authors.forename: Sirus
authors.initials: S
authors.lastname: Khodadadi
authors.forename: Ali
authors.initials: A
authors.lastname: Afrasiabi
authors.forename: Oveis
authors.initials: O
authors.lastname: Karima
authors.forename: Farzad
authors.initials: F
authors.lastname: Mokhtari
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. riazi@ibb.ut.ac.ir.
authors.forename: Elham
authors.initials: E
authors.lastname: Hoveizi
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000838:Anions / Q000737:chemistry / Q000378:metabolism; D002364:Caseins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D066263:Protein Aggregation, Pathological / Q000378:metabolism*; D011487:Protein Conformation; D017510:Protein Folding; D016875:tau Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D000838:Anions; D002364:Caseins; D010446:Peptide Fragments; C542321:amyloid beta-protein (1-12); D016875:tau Proteins