title: Cardioprotective Effects of Atorvastatin plus Trimetazidine in Percutaneous Coronary Intervention.
abstract: OBJECTIVE
  To explore the effects of preoperative administration of conventional doses of atorvastatin plus trimetazidine on the myocardial injury of patients during the perioperative period of percutaneous coronary intervention (PCI).
  
  
  METHODS
  475 cases of acute coronary syndrome patients before PCI were randomly divided into the control group (238 cases) and experimental group (237 cases).The control group was treated with conventional doses of atorvastatin calcium (20 mg each time, once a night), and the experimental group was treated with conventional doses of atorvastatin calcium plus trimetazidine hydrochloride (20 mg each time, tid) for 3 d. After PCI, preoperative and postoperative 24 h concentrations of serum creatine kinase MB isoenzyme (CK-MB), cardiac troponin I (cTnI) and high sensitivity C-reactive protein (hs-CRP) as well as activity of myeloperoxidase (MPO) were investigated. Left ventricular ejection fractions of the patients were then examined 4 weeks later.
  
  
  RESULTS
  Postoperative 24 h cTnI concentration and elevated MPO activity of the experimental group were significantly lower than those of the control group (P <0 05). CK-MB activities and hs-CRP concentrations of the two groups did not differ significantly (P> 0 05).
  
  
  CONCLUSIONS
  The administration of conventional doses of atorvastatin plus trimetazidine three days before PCI is able to protect the perioperative patients from myocardial injury.
authors.affiliation: Xuefeng Lin, Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment & Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province; No.277 Yanta West Road, Xi'an, 710061, P. R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Lin
authors.affiliation: Aiqun Ma, Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment & Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province; No.277 Yanta West Road, Xi'an, 710061, P. R. China.
authors.forename: Aiqun
authors.initials: A
authors.lastname: Ma
authors.affiliation: Wei Zhang, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Qun Lu, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Chaofeng Sun, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Sun
authors.affiliation: Hongyan Tian, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Tian
authors.affiliation: Xinjun Lei, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Lei
authors.affiliation: Xiaojun Bai, Department of Cardiovascular Medicine, First Affiliated Hospital of Baotou Medical College, No.41 Linyin Road, Baotou, 014010, P. R. China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Bai
keywords: Atorvastatin; Cardioprotection; Percutaneous coronary intervention; Trimetazidine