title: [Association of single nucleotide polymorphism of KCNE1 and KCNE4 gene with atrial fibrillation in Xinjiang Uygur and Han population].
abstract: OBJECTIVE
  To investigate the association between the KCNE1 gene G38S and the KCNE4 gene E145D and atrial fibrillation in Uygur and Han populations living in Xinjiang.
  
  
  METHODS
  KCNE1 gene G38S and the KCNE4 gene E145D genotype and frequency were determined using PCR restriction fragment length polymorphism (PCR-RFLP) in 488 atrial fibrillation patients (237 Uygur and 251 Han residents) and 488 age-and-gender matched controls (237 Uygur and 251 Han residents).
  
  
  RESULTS
  Genotype and allele frequency of KCNE1 gene G38S were similar between atrial fibrillation group and control group in the Han population (P = 0.556, P = 0.946). In the Uygur population, there was a statistical difference between atrial fibrillation group and control group (P = 0.018, P = 0.003). Logistic regression analysis revealed the KCNE1 38 G was one of the independent risk factors for atrial fibrillation in the Uygur population (OR = 1.634, 95%CI: 1.192-2.240, P = 0.002). The KCNE4 gene E145D, genotype and allele frequency were significantly different between atrial fibrillation group and control group in the Uygur population and Han population (P = 0.041, P = 0.015;P = 0.032, P = 0.013) . Logistic regression analysis revealed the KCNE4 145D was one of the independent risk factors for atrial fibrillation in the Uygur population and Han population (OR = 1.636, 95%CI:1.173-2.281, P = 0.004; OR = 1.491, 95%CI:1.076-2.065, P = 0.016) .
  
  
  CONCLUSIONS
  KCNE1 G38S is not associated with atrial fibrillation in the Han population while the KCNE1 G38S is associated with atrial fibrillation in the Uygur population. KCNE4 gene E145D is associated with atrial fibrillation in both Uygur population and Han population.
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Mao
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Miao
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Guo-jun
authors.initials: GJ
authors.lastname: Xu
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Tian-yi
authors.initials: TY
authors.lastname: Gan
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Xian-hui
authors.initials: XH
authors.lastname: Zhou
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Fa-peng
authors.initials: FP
authors.lastname: Li
authors.affiliation: The Cardiac Pacing and Electrophysiological Division, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, China. Email: tangbaopeng@hotmail.com.
authors.forename: Bao-peng
authors.initials: BP
authors.lastname: Tang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D001281:Atrial Fibrillation / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D012307:Risk Factors
chemical_list: C489622:KCNE1 protein, human; C498897:KCNE4 protein, human; D024642:Potassium Channels, Voltage-Gated