title: A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema.
abstract: Multicentric Castleman's disease (MCD), a polyclonal lymphoproliferative disorder of unknown aetiology, is a well-recognised complication of HIV disease. We present a case of MCD in an HIV-positive patient that is unusual on two counts: our patient's MCD first presented in the context of an immune restoration inflammatory syndrome (IRIS), following the initiation of highly active antiretroviral therapy (HAART). In addition, her MCD was associated with the unusual complication of acquired angioedema (AAE), which resolved following treatment of the MCD. While AAE is frequently found to have an underlying diagnosis of a lymphoproliferative disease, this is the first reported case linking AAE to MCD.
authors.affiliation: Chalmers Sexual Health Centre, NHS Lothian, Edinburgh, UK imali.fernando@live.co.uk.
authors.forename: I
authors.initials: I
authors.lastname: Fernando
authors.affiliation: Chalmers Sexual Health Centre, NHS Lothian, Edinburgh, UK.
authors.forename: G
authors.initials: G
authors.lastname: Scott
mesh_terms: D000328:Adult; D000799:Angioedema / Q000150:complications*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006679:HIV Seropositivity / Q000150:complications; D015497:HIV-1; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D000069283:Rituximab / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000069283:Rituximab
keywords: AIDS; HAART (highly-active anti-retroviral therapy); HHV-8; HIV; Multicentric Castleman’s disease; acquired angioedema; human herpes virus-8; immune restoration inflammatory syndrome