title: The largest unassigned regions of the male- and female-transmitted mitochondrial DNAs in Musculista senhousia (Bivalvia Mytilidae).
abstract: Musculista senhousia is a marine mussel with doubly uniparental inheritance (DUI) of mitochondria. In this study we analyzed the largest unassigned region (LUR) of its female- and male-transmitted mitochondrial genomes, described their fine characteristics and searched for shared features. Our results suggest that both LURs contain the control region of their respective mitochondrial genomes. The female-transmitted control region is duplicated in tandem, with the two copies evolving in concert. This makes the F-mtDNA of M. senhousia the first Bivalve mitochondrial genome with this feature. We also compared M. senhousia control regions to that of other Mytilidae, and demonstrated that signals for basic mtDNA functions are retained over evolutionary times even among the fast-evolving mitochondrial genomes of DUI species. Finally, we discussed how similarities between female and male LURs may be explained in the context of DUI evolution and if the duplicated female control region might have influenced the DUI system in this species.
authors.affiliation: Department of Biological Geological and Environmental Sciences, University of Bologna, via Selmi 3, 40126 Bologna, Italy. Electronic address: davide.guerra7@unibo.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Guerra
authors.affiliation: Department of Biological Geological and Environmental Sciences, University of Bologna, via Selmi 3, 40126 Bologna, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ghiselli
authors.affiliation: Department of Biological Geological and Environmental Sciences, University of Bologna, via Selmi 3, 40126 Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Passamonti
mesh_terms: D000818:Animals; D001483:Base Sequence; D049872:Bivalvia / Q000235:genetics*; D018389:Codon, Nonsense / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D054629:Genome, Mitochondrial / Q000235:genetics*; D008297:Male; D008928:Mitochondria / Q000235:genetics*; D008969:Molecular Sequence Data
chemical_list: D018389:Codon, Nonsense; D004272:DNA, Mitochondrial
keywords: A; AIC; AT; Akaike information criterion; BF; BIC; Bayes factor; Bayesian information criterion; CR; Concerted evolution; Control region; DUI; Doubly uniparental inheritance; F; GO; LUR; M; Mitochondrial genomes; Musculista senhousia; Mytilids; ORF; T; adenine and thymine content; adenine content; atp8; control region; cox1, −2 and −3; cytb; difference between AIC values; doubly uniparental inheritance; female-transmitted; gene for ATP synthase subunit 8; gene for cytochrome b; gene ontology; genes for NADH dehydrogenase subunits 1, 3, 4L and 5; genes for cytochrome c oxidase subunits 1, 2 and 3; largest unassigned region; male-transmitted; mitochondrial; mt; nad1, −3, −4L and −5; open reading frame; oriH and oriL; origins of heavy and light strand replication; tRNA; tRNA gene for glutamic acid; tRNA gene for glutamine; tRNA-Gln; tRNA-Glu; thymine content; transfer RNA gene; ΔAIC