title: Effects of water extracts of Graptopetalum paraguayense on blood pressure, fasting glucose, and lipid profiles of subjects with metabolic syndrome.
abstract: This study was aimed to investigate the effects of water extracts of Graptopetalum paraguayense (WGP, 4 g/d) on blood pressure, blood glucose level, and lipid profiles in subjects with metabolic syndrome (MS). Participants with MS (n = 54) were randomly assigned to the placebo (n = 28) and WGP groups (n = 26), and the intervention was administered for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose (FG), lipid profiles (total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein (HDL-C)), and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) were measured. Forty-two subjects completed the study (placebo, n = 19; WGP, n = 23). FG, SBP, and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities (CAT and SOD) were significantly higher after WGP supplementation. Blood pressure, FG, and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation (P < 0.05). The present study demonstrated a significant reduction in blood pressure, blood glucose, and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation. Taken together, the antioxidative capacity of WGP might exert a beneficial effect on MS. This trial is registered with ClinicalTrials.gov NCT01463748.
authors.affiliation: Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan ; Center for Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Chi-Hua
authors.initials: CH
authors.lastname: Yen
authors.affiliation: Department of Health Food, Chung Chou University of Science and Technology, Changhua 51003, Taiwan.
authors.forename: Shu-Ju
authors.initials: SJ
authors.lastname: Chen
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Jen-Tzu
authors.initials: JT
authors.lastname: Liu
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Tseng
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan ; Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D029627:Crassulaceae / Q000737:chemistry*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D010936:Plant Extracts