title: GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits.
abstract: Recent development of molecular genetic techniques are rapidly advancing understanding of the functional role of brain circuits in behavior. Critical to this approach is the ability to target specific neuron populations and circuits. The collection of over 250 BAC Cre-recombinase driver lines produced by the GENSAT project provides a resource for such studies. Here we provide characterization of GENSAT BAC-Cre driver lines with expression in specific neuroanatomical pathways within the cerebral cortex and basal ganglia.
authors.affiliation: Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA. Electronic address: gerfenc@mail.nih.gov.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Gerfen
authors.affiliation: Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Paletzki
authors.affiliation: Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Heintz
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics*; D030541:Databases, Genetic; D015870:Gene Expression / Q000235:genetics; D017930:Genes, Reporter / Q000235:genetics; D019426:Integrases / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008959:Models, Neurological; D057054:Molecular Imaging / Q000379:methods; D009434:Neural Pathways / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism
chemical_list: C045073:Cre recombinase; D019426:Integrases