title: Thrombolytic and anticoagulant therapy for acute submassive pulmonary embolism.
abstract: This study aimed to compare the efficacy and safety of thrombolytic and anticoagulant therapy for acute submassive pulmonary embolism (PE). A retrospective evaluation was performed on 25 consecutive inpatients with acute submassive PE treated by thrombolytic therapy and 25 earlier consecutive inpatients with acute submassive PE treated by anticoagulant therapy. No statistically significant difference in clinical curative effect was identified between the thrombolysis and anticoagulation groups (P>0.05). Following 24 h of therapy, the improvement rates of dyspnea and revascularization in the thrombolysis group achieved statistical significance compared with those of the anticoagulation group (P<0.01 for each). The PO2level of the thrombolysis group (81.18±5.66 mmHg) was notably higher than that of the anticoagulation group and the difference was statistically significant (P<0.01). The pulmonary arterial pressures of the thrombolysis group (51.21±6.86 mmHg) were significantly lower than those of the anticoagulation group (60.64±5.17 mmHg) (P<0.01). Furthermore, the difference between the hemorrhage rates of the two groups was statistically significant (P<0.05). Thrombolysis was shown to rapidly relieve dyspnea, reduce pulmonary arterial pressure and revascularize the embolized blood vessels. However, the hemorrhage rate of the thrombolysis group was higher than that of the anticoagulation group. The overall efficacies and fatality rates of the thrombolysis and anticoagulation groups were similar.
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China ; Department of Pulmonary Medicine, Yantai Shan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Fei
authors.affiliation: Department of Pulmonary Medicine, Yantai Shan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Pulmonary Medicine, Yantai Shan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pulmonary Medicine, Yantai Shan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.affiliation: Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Bi
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Junfei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Dong
keywords: anticoagulation; pulmonary embolism; submassive; thrombolysis