title: Feasibility of skin surface elastography by tracking skin surface topography.
abstract: Recent advances have led to a multitude of image modalities being used for visualization of tissue stiffness. High-resolution images of tissue stiffness are desirable, as they have the potential to provide useful diagnostic information. A noncontact optical imaging method has the attractions of low cost, simplicity, and utility when skin contact is undesirable. However, previous optical techniques have required the application of paint or ink to the surface of the skin and so have required contact. Therefore, the present study assessed the feasibility of tracking skin surface topography to produce elastograms. The study showed, by analyzing a variety of silicone skin surface replicas from various body sites of subjects of different ages, that skin surface elastography by tracking surface topography would be feasible. The study further showed that the quality of the strain images can be optimized by measuring skin line pattern frequency. Skin samples with high skin line frequency will achieve best spatial resolution, in the order of 1 mm, comparable to contact techniques reported previously. A mechanically inhomogeneous silicone replica was then imaged, illustrating the technique's ability to detect strain contrast. Finally, the feasibility of implementing the technique in vivo was illustrated using a single pigmented skin lesion.
authors.affiliation: Institute of Cancer Research, Joint Department of Physics, Surrey, England, United Kingdom.
authors.forename: Louise V
authors.initials: LV
authors.lastname: Coutts
authors.affiliation: Institute of Cancer Research, Joint Department of Physics, Surrey, England, United Kingdom.
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Miller
authors.affiliation: Epsom & St. Helier University Hospital NHS Trust, Department of Dermatology, Surrey, England, United Kingdom.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Harland
authors.affiliation: Institute of Cancer Research, Joint Department of Physics, Surrey, England, United Kingdom.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Bamber
mesh_terms: D000328:Adult; D004548:Elasticity / Q000502:physiology*; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D009506:Nevus / Q000473:pathology / Q000503:physiopathology; D019047:Phantoms, Imaging; D012826:Silicone Elastomers; D012867:Skin / Q000473:pathology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000473:pathology / Q000503:physiopathology; D012879:Skin Physiological Phenomena
chemical_list: D012826:Silicone Elastomers