title: Prognostic factors for outcome in pediatric probable lesional frontal lobe epilepsy with an unknown cause (cryptogenic).
abstract: The outcomes of children with cryptogenic seizures most probably arising from the frontal lobe are difficult to predict. We retrospectively collected data on 865 pediatric patients with epilepsy. In 78 patients with cryptogenic frontal lobe epilepsy, the age at first seizure was inversely correlated with the outcome, including the degree of intellectual disability/developmental delay (P = .002) and seizure frequency (P = .02) after adequate treatment. Intellectual disability was more prevalent in children with a first seizure at 0 to 3 years old (P = .002), and seizures were more frequent in those with a first seizure at 0 to 6 years old than at 7 to 16 years old (P = .026). For pediatric cryptogenic frontal lobe epilepsy, the age at first seizure is important and inversely correlated with outcome, including seizure frequency and intellectual disability.
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan y610@mercury.csmu.edu.tw.
authors.forename: Inn-Chi
authors.initials: IC
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan pcyj@mail.ncku.edu.tw.
authors.forename: Yung-Jung
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Hong-Shen
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Shuan-Yow
authors.initials: SY
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology*; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D010372:Pediatrics; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies
keywords: child; cryptogenic; frontal lobe epilepsy; outcome; prognosis