title: Comparison of serum fatty acid concentrations in cats with hypertrophic cardiomyopathy and healthy controls.
abstract: n-3 fatty acids have some benefits in humans and dogs with cardiac disease, and plasma n-3 fatty acid concentrations have been shown to be decreased in dogs with congestive heart failure (CHF). However, there are no published studies reporting fatty acid concentrations in cats with cardiac disease. Therefore, the goal of this study was to compare serum fatty acid concentrations in normal cats and cats with hypertrophic cardiomyopathy (HCM), and determine if fatty acid concentrations correlate with left atrial size or the presence of CHF. Serum fatty acid concentrations were measured in normal cats and cats with HCM by gas chromatography. Twenty-three cats with HCM and 20 healthy controls were enrolled. Compared with healthy controls, cats with HCM had higher concentrations of palmitic acid (P = 0.01), docosahexanoic acid (DHA; P = 0.001) and total n-3 fatty acids (P = 0.03), and lower concentrations of linoleic acid (P = 0.03). Among cats with HCM, there were no differences in plasma fatty acid concentrations, and no association between left atrial dimension and fatty acid concentrations. Cats with HCM have some alterations in plasma fatty acids compared with healthy controls. Given the higher plasma concentrations of DHA, DHA supplementation is unlikely to have benefits in terms of correcting a deficiency; however, other effects of DHA or of supplementation of EPA warrant further investigation.
authors.affiliation: Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Hall
authors.affiliation: Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA lisa.freeman@tufts.edu.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Freeman
authors.affiliation: Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Rush
authors.affiliation: Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Cunningham
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood*; D002415:Cats; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D012016:Reference Values
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid