title: Transformation of physical DVHs to radiobiologically equivalent ones in hypofractionated radiotherapy analyzing dosimetric and clinical parameters: a practical approach for routine clinical practice in radiation oncology.
abstract: OBJECTIVE
  The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionated Radiotherapy.
  
  
  METHODS
  To achieve this transformation, we used both the linear-quadratic model (LQ model) and the Niemierko model. The outcome of radiobiological DVHs was correlated with acute toxicity score according to EORTC/RTOG criteria.
  
  
  RESULTS
  Concerning the prostate radiotherapy, there was a significant correlation between RTOG acute rectal toxicity and D50 (P < 0.001) and V60 (P = 0.001) dosimetric parameters, calculated for α/β = 10 Gy. Moreover, concerning the breast radiotherapy there was a significant correlation between RTOG skin toxicity and V(≥60) dosimetric parameter, calculated for both α/β = 2.3 Gy (P < 0.001) and α/β = 10 Gy (P < 0.001). The new tool seems reliable and user-friendly.
  
  
  CONCLUSIONS
  Our proposed model seems user-friendly. Its reliability in terms of agreement with the presented acute radiation induced toxicity was satisfactory. However, more patients are needed to extract safe conclusions.
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Zoi
authors.initials: Z
authors.lastname: Thrapsanioti
authors.affiliation: Microwave and Fiber Optics Laboratory, Computer and Electrical Engineering, National Technical University of Athens, Iroon Polytechniou 9, Zografoy, 15780 Athens, Greece.
authors.forename: Irene
authors.initials: I
authors.lastname: Karanasiou
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Platoni
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Efstathios P
authors.initials: EP
authors.lastname: Efstathopoulos
authors.affiliation: Microwave and Fiber Optics Laboratory, Computer and Electrical Engineering, National Technical University of Athens, Iroon Polytechniou 9, Zografoy, 15780 Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Matsopoulos
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dilvoi
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Patatoukas
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Demetrios
authors.initials: D
authors.lastname: Chaldeopoulos
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kelekis
authors.affiliation: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Rimini 1, Haidari, 12462 Athens, Greece ; Microwave and Fiber Optics Laboratory, Computer and Electrical Engineering, National Technical University of Athens, Iroon Polytechniou 9, Zografoy, 15780 Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Kouloulias
mesh_terms: D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D015203:Reproducibility of Results