title: Association between first-trimester placental volume and birth weight.
abstract: OBJECTIVE
  To estimate the correlation between first-trimester placental volume, birth weight, small-for-gestational-age (SGA), and preeclampsia.
  
  
  METHODS
  A prospective study of women with singleton pregnancy at 11-13 weeks of gestation was conducted. First-trimester placental volume was measured using three-dimensional ultrasound and reported as multiple of median (MoM) for gestational age. Participants were followed until delivery where birth weight, placental weight, and occurrence of preeclampsia were collected. Non-parametric analyses were performed.
  
  
  RESULTS
  We reached a complete follow-up for 543 eligible women. First-trimester placental volume was significantly correlated with birth weight (correlation coefficient: 0.18; p < 0.0001) and placental weight (cc: 0.22; p < 0.0001) adjusted for gestational age. First-trimester placental volume was smaller in women who delivered SGA neonates (median MoM: 0.79; interquartile range: 0.62-1.00; p < 0.001) and greater in women who delivered large-for-gestational-age neonates (median MoM: 1.13; 0.95-1.49; p < 0.001) when compared to women with neonates between the 10th and 90th percentile (median MoM: 1.00; 0.81-1.25). First-trimester placental volume was not associated with the risk of preeclampsia (cc: 0.01; p = 0.87).
  
  
  CONCLUSIONS
  First-trimester placental volume is strongly associated with fetal and placental growth. However, we did not observe a correlation between placental volume and the risk of preeclampsia.
authors.affiliation: Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Effendi
authors.affiliation: Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada; Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Demers
authors.affiliation: Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Giguère
authors.affiliation: Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada.
authors.forename: J-C
authors.initials: JC
authors.lastname: Forest
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Brassard
authors.affiliation: Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Girard
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Gouin
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada; Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada. Electronic address: emmanuel.bujold@crchul.ulaval.ca.
authors.forename: E
authors.initials: E
authors.lastname: Bujold
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D011225:Pre-Eclampsia; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
keywords: First-trimester; Placenta; Preeclampsia; Pregnancy; SGA; Ultrasound