title: Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice.
abstract: Lactoferrin (LF) is recognized as a host defensive glycoprotein, especially for newborn infants. The aim of this study was to investigate whether orally administered LF had protective activity against UV-induced skin damage in hairless mice. Transepidermal water loss and skin hydration were evaluated in nonirradiated mice, UVB-irradiated mice, and UVB-irradiated and LF-administered mice. Supplementation with LF (1,600 mg/kg per day) effectively suppressed the increase in transepidermal water loss, reduction in skin hydration, aberrant epidermal hyperplasia, and cell apoptosis induced by UV irradiation. Although no significant changes in superoxide dismutase-like activity or malondialdehyde levels were observed in the skin with both UV irradiation and LF administration, UV-stimulated IL-1β levels in the skin were significantly suppressed by the administration of LF. Oral supplementation with LF has the potential to reduce IL-1β levels and prevent UV-induced skin damage. Further studies are needed to elucidate the relationships between the antiinflammatory effects and skin protective function of LF.
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co. Ltd., Zama-City, Kanagawa 252-8583, Japan; Applied Protein Chemistry, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-City, Tokyo 183-8509, Japan. Electronic address: m-murata@morinagamilk.co.jp.
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co. Ltd., Zama-City, Kanagawa 252-8583, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co. Ltd., Zama-City, Kanagawa 252-8583, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Wakabayashi
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co. Ltd., Zama-City, Kanagawa 252-8583, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co. Ltd., Zama-City, Kanagawa 252-8583, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Abe
authors.affiliation: Applied Protein Chemistry, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-City, Tokyo 183-8509, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002417:Cattle; D004032:Diet; D019587:Dietary Supplements / Q000032:analysis; D007781:Lactoferrin / Q000008:administration & dosage / Q000378:metabolism*; D051379:Mice; D008812:Mice, Hairless; D012871:Skin Diseases / Q000209:etiology / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D007781:Lactoferrin
keywords: UV-induced skin damage; antiinflammatory effect; hairless mice; lactoferrin