title: [8p11 myeloproliferative syndrome cured by allogeneic hematopoietic stem cell transplantation: two case reports and literature review].
abstract: OBJECTIVE
  To report 2 rare cases of 8p11 meyloproliferative syndrome cured by allogeneic hematopoietic stem cell transplantation.
  
  
  METHODS
  The clinical and laboratory features of 2 cases of 8p11 meyloproliferative syndrome were summarized, including the diagnosis and treatment process of allogeneic hematopoietic stem cell transplantation.
  
  
  RESULTS
  Patient 1 was presented with bilateral cervical lymphadenopathy and leukocytosis. The pathology of bone marrow showed extremely hyperplasia. The cytogenetic analysis showed a 46, XY, (8;13)(p11;q12) karyotype. The biopsy of the lymph node was peripheral T-cell lymphoma, unspecified. Patient 2 was presented with extensive lymphadenopathy with abnormal hemogram, which was leuekcytosis and thrombpenia. The bone marrow was hypercellular. The cytogenetic analysis on the bone marrow cells showed a translocation of t(8;9) (p11;q32). The CEP110-FGFR1 fusion transcript was detected by RT-PCR. The biopsy of the lymph node was T lymphoblastic lymphoma. These two patients received human leukocyte antigen (HLA)-identical allogeneic hematopoietic stem cell transplantation, remained disease-free and survived 16 years and 6 years after transplantation, respectively.
  
  
  CONCLUSIONS
  Allogeneic hematopoietic stem cell transplantation is the curative therapy for 8p11 meyloproliferative syndrome.
authors.affiliation: Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Shi
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous