title: The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort.
abstract: MTHFD1 1958G>A, a polymorphism in folate metabolism, increases risk of pregnancy complications. A mouse model exhibited developmental defects, increased weight and decreased leukocyte counts. To examine the latter associations, we genotyped 651 women from a premature birth cohort. Prematurity and 1958G>A were not associated. Increases in the inflammatory marker CRP (logistic regression, p = 0.055) and BMI (chi-square, p = 0.0113) were associated with AA genotype in women with low folate. MTHFD1 1958G>A may influence immune function and obesity.
authors.affiliation: Dept. of Human Genetics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada; Dept. of Pediatrics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: karen.christensen@mail.mcgill.ca.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Christensen
authors.affiliation: Dept. of Pediatrics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: Mourad.Dahhou@muhc.mcgill.ca.
authors.forename: Mourad
authors.initials: M
authors.lastname: Dahhou
authors.affiliation: Dept. of Pediatrics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada; Dept. of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada. Electronic address: michael.kramer@mcgill.ca.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kramer
authors.affiliation: Dept. of Human Genetics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada; Dept. of Pediatrics, McGill University, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: rima.rozen@mcgill.ca.
authors.forename: Rima
authors.initials: R
authors.lastname: Rozen
mesh_terms: D000818:Animals; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000096:biosynthesis*; D002170:Canada; D005260:Female; D005492:Folic Acid / Q000235:genetics / Q000378:metabolism*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D051379:Mice; D015778:Minor Histocompatibility Antigens; D009765:Obesity / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics* / Q000473:pathology; D015430:Weight Gain / Q000235:genetics
chemical_list: D015778:Minor Histocompatibility Antigens; D002097:C-Reactive Protein; D005492:Folic Acid; C539735:MTHFD1 protein, human; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP)
keywords: Body mass index; C-reactive protein; Folate; MTHFD1; Obesity