title: Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes.
abstract: Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.
authors.affiliation: UMR8126, Université Paris-Sud 11, CNRS, Institut de cancérologie Gustave Roussy, Villejuif, France; INSERM U1046, Université Montpellier I, Montpellier, France.
authors.forename: Petr
authors.initials: P
authors.lastname: Dmitriev
authors.forename: Ulykbek
authors.initials: U
authors.lastname: Kairov
authors.forename: Thomas
authors.initials: T
authors.lastname: Robert
authors.forename: Ana
authors.initials: A
authors.lastname: Barat
authors.forename: Vladimir
authors.initials: V
authors.lastname: Lazar
authors.forename: Gilles
authors.initials: G
authors.lastname: Carnac
authors.forename: Dalila
authors.initials: D
authors.lastname: Laoudj-Chenivesse
authors.forename: Yegor S
authors.initials: YS
authors.lastname: Vassetzky
mesh_terms: D002869:Chromosome Aberrations; D002894:Chromosomes, Human, Pair 4; D044127:Epigenesis, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D032446:Myoblasts / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D061251:Primary Cell Culture; D012512:Sarcoma, Ewing / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D059467:Transcriptome
chemical_list: D009363:Neoplasm Proteins
keywords: Ewing's sarcoma; FSHD; cancer; muscular dystrophy; rhabdomyosarcoma