title: Role of microRNAs in stroke and poststroke depression.
abstract: microRNAs (miRNA), a sort of noncoding RNAs widely distributed in eukaryotic cells, could regulate gene expression by inhibiting transcription or translation. They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. Recent studies have demonstrated that some miRNAs play important roles in the occurrence and development of ischemic cerebrovascular diseases such as stroke and were also involved in the occurrence and development of poststroke depression (PSD). Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.
authors.forename: Min
authors.initials: M
authors.lastname: Fang
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
mesh_terms: D002545:Brain Ischemia / Q000235:genetics / Q000503:physiopathology; D003866:Depressive Disorder / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology; D020521:Stroke / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology
chemical_list: D035683:MicroRNAs