title: Diurnal triglyceridemia in relation to alcohol intake in men.
abstract: Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10-30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve (∆cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at bedtime (p for trend <0.001) which persisted after adjustment for age, smoking and body mass index. The ∆cTG-AUC was significantly lower in males with low alcohol intake (3.0 ± 1.9 mmol·h/L) (n = 27) compared to males with no (7.0 ± 1.8 mmol·h/L) (n = 34), moderate (6.5 ± 1.8 mmol·h/L) (n = 54) or high alcohol intake (7.2 ± 2.2 mmol·h/L) (n = 24), when adjusted for age, smoking and body mass index (adjusted p value < 0.05). In males, low alcohol intake was associated with decreased diurnal triglyceridemia, whereas moderate and high alcohol intake was associated with increased triglycerides after dinner and at bed time.
authors.forename: Ana
authors.initials: A
authors.lastname: Torres do Rego
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Klop
authors.forename: Erwin
authors.initials: E
authors.lastname: Birnie
authors.forename: Jan Willem F
authors.initials: JW
authors.lastname: Elte
authors.forename: Victoria Cachofeiro
authors.initials: VC
authors.lastname: Ramos
authors.forename: Luis A Alvarez-Sala
authors.initials: LA
authors.lastname: Walther
authors.affiliation: Department of Internal Medicine, Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, P.O. Box 10900, Rotterdam 3004 BA, The Netherlands. m.castrocabezas@sfg.nl.
authors.forename: Manuel Castro
authors.initials: MC
authors.lastname: Cabezas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects*; D015992:Body Mass Index; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011795:Surveys and Questionnaires; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D014280:Triglycerides