title: [Evaluation for the clinical application of all embryos cryopreservation: a multi-centre study in northern area of China].
abstract: OBJECTIVE
  To investigate the clinical outcome of patients who underwent cryopreservation of all embryos.
  
  
  METHODS
  A retrospective analysis was made in the clinical data of patients with cryopreservation of all embryos between April 2011 and September 2011 in four hospitals of North China. The patients were divided into five groups according to the reasons of cryopreservation of all embryos: ovarian hyperstimulation syndrome (OHSS) group, serum progesterone elevation group, endometrial group, hydrosalpinx group and others. The clinical pregnancy rate per transfer, implantation rate and cumulative clinical pregnancy rate were analyzed.
  
  
  RESULTS
  The clinical pregnancy rate, implantation rate and cumulative clinical pregnancy rate of the OHSS group were 55.4%, 34.8% and 73.7%, respectively. The rates of the serum progesterone elevation group were 25.5%, 11.2% and 43.1%, respectively. The rates of the endometrial group were 54.8%, 34.4% and 61.5%, respectively. The rates of the hydrosalpinx group were 60%, 30% and 60%, respectively. The rates of the other factors group were 36.0%, 24.5% and 44.0%, respectively.
  
  
  CONCLUSIONS
  The strategy of cryopreservation of all embryos could improve the clinical outcomes of patients with severe OHSS. It still needs a large multi-centre, randomized trial to evaluate its effectiveness and side effects, although it has the positive clinical application for other reasons of cryopreservation of all embryos.
authors.affiliation: Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Center of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Gui-min
authors.initials: GM
authors.lastname: Hao
authors.affiliation: Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.
authors.forename: Xiu-xia
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Center of Reproductive Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China.
authors.forename: Yun-shan
authors.initials: YS
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000328:Adult; D002681:China; D015925:Cryopreservation; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D005184:Fallopian Tube Diseases / Q000517:prevention & control; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014591:Uterine Diseases / Q000517:prevention & control
chemical_list: D011374:Progesterone