title: [Role of the p53 tumor suppressor in metabolism].
abstract: The p53 tumor suppressor is an essential downstream effector of various cellular stress response pathways that is functionally inactivated in most, if not all, tumors. Since its discovery more than 30 years ago, its role in the control of cell proliferation, senescence and cell survival has been widely described. However, growing evidences from several laboratories indicate that p53 has important transcriptional and non-transcriptional functions in the control of metabolism, including the regulation of glycolysis, glutaminolysis or mitochondrial respiration. Originally identified using in vitro cellular models, this previously underestimated role of p53 has been confirmed in vivo in various genetically engineered mouse models. These recent data suggest that p53 functions in various metabolic pathways significantly contribute to its role in adult tissue homeostasis, aging as well as tumor suppression.
authors.affiliation: Institut de recherche en cancérologie de Montpellier, Inserm U896, Institut régional de lutte contre le cancer (ICM), université Montpellier 1, 208, rue des apothicaires, 34298 Montpellier Cedex, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Lacroix
authors.affiliation: Institut de recherche en cancérologie de Montpellier, Inserm U896, Institut régional de lutte contre le cancer (ICM), université Montpellier 1, 208, rue des apothicaires, 34298 Montpellier Cedex, France.
authors.forename: Laetitia Karine
authors.initials: LK
authors.lastname: Linares
authors.affiliation: Institut de recherche en cancérologie de Montpellier, Inserm U896, Institut régional de lutte contre le cancer (ICM), université Montpellier 1, 208, rue des apothicaires, 34298 Montpellier Cedex, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Le Cam
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology; D006019:Glycolysis / Q000235:genetics / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D008660:Metabolism / Q000235:genetics / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53