title: Flow microreactor synthesis in organo-fluorine chemistry.
abstract: Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often faced with problems such as the difficulties in handling of fluorinating reagents and in controlling of chemical reactions. Recently, flow microreactor synthesis has emerged as a new methodology for producing chemical substances with high efficiency. This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.
authors.affiliation: Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Amii
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Yoshida
keywords: defluorination; flow microreactor; fluorination; fluorine; organo-fluorine; perfluoroalkylation