title: Serotonin 1A receptors and sexual behavior in a genetic model of depression.
abstract: The Flinder Sensitive Line (FSL) is a rat strain that displays distinct behavioral and neurochemical features of major depression. Chronic selective serotonin reuptake inhibitors (SSRIs) are able to reverse these symptoms in FSL rats. It is well known that several abnormalities in the serotonergic system have been found in FSL rats, including increased 5-HT brain tissue levels and reduced 5-HT synthesis. SSRIs are known to exert (part of) their effects by desensitization of the 5-HT₁A receptor and FSL rats appear to have lower 5-HT1A receptor densities compared with Flinder Resistant Line (FRL) rats. We therefore studied the sensitivity of this receptor on the sexual behavior performance in both FRL and FSL rats. First, basal sexual performance was studied after saline treatment followed by treatment of two different doses of the 5-HT₁A receptor agonist ±8-OH-DPAT. Finally we measured the effect of a 5-HT₁A receptor antagonist to check for specificity of the 5-HT₁A receptor activation. Our results show that FSL rats have higher ejaculation frequencies compared with FRL rats which do not fit with a more depressive-like phenotype. Moreover FRL rats are more sensitive to effects of ±8-OH-DPAT upon EL and IF than FSL rats. The blunted response of FSL rats to the effects of ±8-OH-DPAT may be due to lower densities of 5-HT₁A receptors.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Schijven
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Sweden.
authors.forename: V C
authors.initials: VC
authors.lastname: Sousa
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Roelofs
authors.affiliation: Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, The Netherlands; Dept. of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: B
authors.initials: B
authors.lastname: Olivier
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Sweden; Department of Women's and Children's Health, Uppsala University, Sweden; Centre for Gender Medicine, Karolinska Institute, Sweden. Electronic address: jocelien.olivier@ki.se.
authors.forename: J D A
authors.initials: JD
authors.lastname: Olivier
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D004195:Disease Models, Animal; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics* / Q000502:physiology*; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*
chemical_list: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D044282:Receptor, Serotonin, 5-HT1A; D058825:Serotonin 5-HT1 Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors
keywords: 5-HT(1A)-receptor; 8-OH-DPAT; Flinder Resistant rat Line; Flinder Sensitive rat Line; Sexual behavior; WAY100635