title: The role of diminishing appetite and serum nesfatin-1 level in patients with burn wound infection.
abstract: BACKGROUND
  The burn wound represents a susceptible site for opportunistic colonization by organisms of endogenous and exogenous origin. Diminishing appetite is known to occur in patients with burn infection, yet its underlying reason is not fully understood. We have examined the levels of nesfatin 1, a protein that we consider to be a potential new treatment target for the solution of appetite and nutrition problem in patients with burn infection.
  
  
  OBJECTIVE
  The aim of the present study was therefore to examine nesfatin levels in patients with burn infection.
  
  
  METHODS
  Laboratory values, medication and dietary records, and patient notes with diagnostic information of burn wounds patients who were admitted to the Division of Burn Treatment Center were obtained from the Erzurum Region Education and Research Hospital electronic database. Post-burn wound infection was objectively assessed by culturing wound homogenates from skin tissue. The main immediate inflammatory stress response parameters assessed were serum CRP concentrations, WBC counts, and blood nesfatin concentrations.
  
  
  RESULTS
  Scalding was the predominant cause of burns in both categories of patients. In 19 (61.3%) burn wound infection patients, the burns were due to a scald. A significant difference was found for the nesfatin, CRP, and WBC levels between the patients and the control group (P = 0.000). A significant difference was also determined between the nesfatin, CRP, and WBC figures at the time of hospitalization and at discharge from the hospital (P = 0.000). The most predominant bacterial isolate was Pseudomonas aeruginosa 16 (51.6%) followed by Methicilline resistant Staphylococcus aureus (MRSA) 7 (22.6%).
  
  
  CONCLUSIONS
  We showed that the serum nesfatin 1 level was significantly lower in the patients with burn than in the control group in our study. We considered that the central nesfatin 1 system should be taken into consideration, rather than the peripheric nesfatin 1 system, when considering the regulation of appetite in patients with burns and particularly those accompanied by infection. In other explanation of the observed negative correlation between nesfatin 1 and burn wound infection suggests that nesfatin 1 may indicate the possible contribution of nesfatin 1 to the energy homeostasis.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Albayrak
authors.affiliation: Department of General Surgery, Ibn-i Sina Hospital, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Demiryilmaz
authors.affiliation: Department of General Surgery and Burn Unit, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Albayrak
authors.affiliation: Department of General Surgery and Burn Unit, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Belkiz
authors.initials: B
authors.lastname: Aylu
authors.affiliation: Department of General Surgery and Burn Unit, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Bunyami
authors.initials: B
authors.lastname: Ozogul
authors.affiliation: Department of Internal Medicine, Ataturk University, Faculty of Medicine, Erzurum, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Cerrah
authors.affiliation: Department of Biochemistry, Ataturk University, Faculty of Medicine, Erzurum, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Celik
keywords: Appetite; Burns; Nucleobindin; Wound Infection