title: Time trends and outcome of gastrointestinal bleeding in the Veneto region: a retrospective population based study from 2001 to 2010.
abstract: BACKGROUND
  Gastrointestinal bleeding is the most frequent emergency for gastroenterologists. Despite advances in management, an improvement in mortality is still not evident.
  
  
  OBJECTIVE
  Determining time trends of gastrointestinal bleeding hospitalization and outcomes from 2001 to 2010 in the Veneto Region (Italy).
  
  
  METHODS
  Data of patients admitted with gastrointestinal bleeding from Veneto regional discharge records were retrospectively evaluated. Chi-squared and multivariate logistic regression model were used.
  
  
  RESULTS
  Overall, 44,343 patients (mean age 64.2 ± 8.6 years) with gastrointestinal bleeding were analysed: 23,450 (52.9%) had upper, 13,800 (31.1%) lower, and 7093 (16%) undefined gastrointestinal bleeding. Admission rate decreased from 108.0 per 100,000 in 2001 to 80.7 in 2010, mainly owing to a decrease in upper gastrointestinal bleeding (64.4 to 35.9 per 100,000, p<0.05). Reductions in hospital fatality rate (from 5.3% to 3%, p<0.05), length of hospital stay (from 9.3 to 8.7 days, p<0.05), and need for surgery (from 5.6% to 5%, p<0.05) were observed. Surgery (OR: 2.97, 95% CI: 2.59-3.41) and undefined gastrointestinal bleeding (OR: 2.89, 95% CI: 2.62-3.19) were found to be risk factors for mortality.
  
  
  CONCLUSIONS
  Patient admissions for gastrointestinal bleeding decreased significantly over the years, owing to a decrease in upper gastrointestinal bleeding. Improved outcomes could be related to regional dedicated clinical gastroenterological management.
authors.affiliation: Gastroenterology Unit, S. Martino Hospital, Belluno, Italy. Electronic address: lucas.cavallaro@ulss.belluno.it.
authors.forename: Lucas G
authors.initials: LG
authors.lastname: Cavallaro
authors.affiliation: Gastroenterology Unit, S. Bassiano Hospital, Bassano del Grappa (VI), Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monica
authors.affiliation: Gastroenterology Unit, S. Martino Hospital, Belluno, Italy.
authors.forename: Bastianello
authors.initials: B
authors.lastname: Germanà
authors.affiliation: Gastroenterology Unit, Hospital of Dolo (VE), Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Marin
authors.affiliation: Gastroenterology Division, University of Padua, Italy.
authors.forename: Giacomo C
authors.initials: GC
authors.lastname: Sturniolo
authors.affiliation: Health Directorate, Veneto Region, Venezia, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Saia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D017052:Hospital Mortality / Q000639:trends*; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D007902:Length of Stay / Q000639:trends; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Incidence; Lower gastrointestinal bleeding; Mortality; Upper gastrointestinal bleeding