title: Two-component systems in Streptomyces: key regulators of antibiotic complex pathways.
abstract: Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary "sensing" device.Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.
authors.forename: Héctor
authors.initials: H
authors.lastname: Rodríguez
authors.forename: Sergio
authors.initials: S
authors.lastname: Rico
authors.forename: Margarita
authors.initials: M
authors.lastname: Díaz
authors.affiliation: Instituto de Biología Funcional y Genómica (IBFG)/Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, C/ Zacarías González, n° 2, 37007 Salamanca, Spain. santa@usal.es.
authors.forename: Ramón I
authors.initials: RI
authors.lastname: Santamaría
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D064210:Secondary Metabolism; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents