title: Finding Optimized Conditions of Slit-Slat and Multislit-Slat Collimation for Breast Imaging.
abstract: In order to develop a breast-imaging system for Single Photon Emission Computed Tomography (SPECT) using slit-slat and multislit-slat collimators, we searched for optimized geometric parameters of the collimators. For this study, we employed two independent metrics to validate each result: 1) Signal to Noise Ratio (SNR) based on the Cramer-Rao lower Bound (CRB) and 2) contrast at the same noise level from an ensemble. We calculated SNR values using forward-projection data of an anthropomorphic digital phantom containing two lesions in the breast (one at the chest wall and the other at the center) with a simulated slit-slat collimator as a function of the collimator's geometric parameters. We also calculated contrast values from reconstructed images with noise. Based on the results from the slit-slat case, we investigated angular range, SNR, and contrast for the multislit-slat. We saw similar trends of the two metrics. One interesting property of the multislit-slat is that the imaging performance depends on the orientation of the field of view (FOV) of the side slits. When we compared the metric values for the slit-slat and multislit-slat, improvement was seen only when the lesion was in the FOV of the side slits. Therefore, tuning the parameters of the multislit-slat to optimally detect lesions at the chest wall might be a sensible option since the slit-slat already provides good image quality for center and superficial lesions.
authors.affiliation: Department of Radiology at The University of Pennsylvania, Philadelphia, PA 19104 USA.
authors.forename: Daekwang
authors.initials: D
authors.lastname: Kau
authors.affiliation: Department of Radiology at The University of Pennsylvania, Philadelphia, PA 19104 USA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Metzler
keywords: sensitivity; single photon emission computed tomography (SPECT); slit-slat