title: [Hypothermia as a treatment for hypoxic ischemic encephalopathy after neonatal asphyxia--update].
abstract: Hypoxic-ischemic encephalopathy (HIE) due to neonatal asphyxia is an important cause of irreversible bad neurodevelopmental outcomes in children. Understanding the mechanisms causing the central nervous system cell death enabled the development of new treatment strategies that may decrease the severity of neurological damage. This survey includes data on epidemiology, pathogenesis, clinical features and diagnostic criteria of HIE. We discuss the neuro-protective mechanisms of therapeutic hypothermia and provide data on clinical studies conducted to investigate the impact and safety of this treatment in newborn infants affected by HIE. In addition, other therapeutic options of neuro-protective agents are mentioned.
authors.affiliation: Department of Neonatology, Carmel Medical Center, Haifa, Israel. kesselira@clalit.org.il
authors.forename: Irena
authors.initials: I
authors.lastname: Kessel
authors.affiliation: Department of Neonatology, Carmel Medical Center, Haifa, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Waisman
authors.affiliation: Department of Radiology, Carmel Medical Center, Haifa, Israel.
authors.forename: Menashe
authors.initials: M
authors.lastname: Barzilai
authors.affiliation: Department of Neonatology, Carmel Medical Center, Haifa, Israel.
authors.forename: Marina
authors.initials: M
authors.lastname: Soloveichick
authors.affiliation: Department of Neonatology, Carmel Medical Center, Haifa, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Rotschild
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012720:Severity of Illness Index
chemical_list: D018696:Neuroprotective Agents