title: IRS1, TCF7L2, ADRB1, PPARG, and HHEX polymorphisms associated with atherogenic risk in Mexican population.
abstract: Objective. We aimed to explore the association between polymorphisms of IRS1 (rs1801278), TCF7L2 (rs7903146 and rs12255372), ADRB1 (rs1801253), PPARG (rs1801282), and HHEX (rs5015480) genes with atherogenic risk (AI = Total cholesterol/HDL) in MetS, T2D, and healthy populations from the Mexican Social Security Institute. Methodology and Results. Four hundred thirty-five MetS, 517 T2D, and 547 healthy individuals were selected. The association between the SNPs and the atherogenic index was evaluated by multiple linear regression and multinomial logistic regression models. The ADRB1 gene showed a statistically significant association with high-risk atherogenic index, OR = 2.94 (IC 95% 1.64-5.24; P < 0.0001) for the Arg/Gly variant, under the dominant model an OR = 2.96 (IC 95% 1.67-5.25; P < 0.0001), and under the Log additive model an OR = 2.52 (IC 95% 1.54-4.15; P < 0.0001). Conclusions. The Arg389Gly polymorphism of the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index.
authors.affiliation: Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca, 62100 Cuernavaca, MOR, Mexico.
authors.forename: B I
authors.initials: BI
authors.lastname: Estrada-Velasco
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, Avenida Cuauhtémoc 330, Doctores, Cuauhtémoc, CMN Siglo XXI, 06720 México, DF, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca, 62100 Cuernavaca, MOR, Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Madrid-Marina
authors.affiliation: Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca, 62100 Cuernavaca, MOR, Mexico.
authors.forename: G A
authors.initials: GA
authors.lastname: Martínez-Nava
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, Avenida Cuauhtémoc 330, Doctores, Cuauhtémoc, CMN Siglo XXI, 06720 México, DF, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Gomez-Zamudio
authors.affiliation: Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca, 62100 Cuernavaca, MOR, Mexico.
authors.forename: A I
authors.initials: AI
authors.lastname: Burguete-García
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: C547787:ADRB1 protein, human; D008076:Cholesterol, HDL; C078492:HHEX protein, human; D018398:Homeodomain Proteins; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D047495:PPAR gamma; D018342:Receptors, Adrenergic, beta-1; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors