title: [The history of hepatitis B virus-related determination tests and inspection and the measurements of problems in Japan].
abstract: Since Hepatitis B virus was detected as the cause of hepatitis, many high-sensitive measurement methods have been developed. In the development history, there are many problems in accuracy, sensitivity and health insurance regulations among different types of kits with different measurement principles. Advanced medical treatments cause problems of gene mutation or reactivation of HBV, leading to the necessity for high sensitive and sophisticated determination. The history of clinical analysis for the detection of HBV was reviewed from the viewpoint of our experiences.
authors.affiliation: Central Clinical Laboratory, Shimane University Hospital, Izumo 693-8501. Shibata.Hiroshi@sysmex.co.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
mesh_terms: D006509:Hepatitis B / Q000175:diagnosis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007564:Japan; D009154:Mutation / Q000235:genetics; D014775:Virus Activation
chemical_list: D006514:Hepatitis B Surface Antigens