title: How DNA is damaged by external electric fields: selective mutation vs. random degradation.
abstract: DNA is constantly exposed to exogenous agents that randomly damage the genetic code. However, external perturbations might also be used to induce malignant cell death if the mutation processes are controlled. The present communication reports a set of parameters allowing DNA mutation through the use of intense external electric fields. This is a step towards the design of pulsed electric field therapy for genetic diseases.
authors.affiliation: Departemento de Química Física, Universidad de Murcia, 30100 Murcia, Spain. jpceron@um.es.
authors.forename: José Pedro
authors.initials: JP
authors.lastname: Cerón-Carrasco
authors.forename: Javier
authors.initials: J
authors.lastname: Cerezo
authors.forename: Denis
authors.initials: D
authors.lastname: Jacquemin
mesh_terms: D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004574:Electromagnetic Fields; D009154:Mutation; D011789:Quantum Theory; D013816:Thermodynamics
chemical_list: D004247:DNA