title: Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing β-human chorionic gonadotropin.
abstract: Giant cell tumor of bone is a benign, locally aggressive neoplasm that is composed of sheets of neoplastic mononuclear cells interspersed amongst non-neoplastic, uniformly distributed, osteoclast-like giant cells. They represent approximately 4-5% of primary bone tumors. Rarely, bone tumors have been noted to produce human chorionic gonadotropin, a finding most often reported in osteosarcoma. We present the case of a young woman who presented with a low-level human chorionic gonadotropin level which, after resection of her recurrent giant cell tumor of bone with secondary aneurysmal bone cyst-like change, became undetectable in her blood. Furthermore, cells within the aneurysmal bone cyst component were immunohistochemically positive for β-human chorionic gonadotropin. This is the first report of such a finding in the literature.
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers, the State University of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA, fitzhuva@njms.rutgers.edu.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Fitzhugh
authors.forename: Gordana
authors.initials: G
authors.lastname: Katava
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wenokor
authors.forename: Natalie
authors.initials: N
authors.lastname: Roche
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Beebe
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood; D017824:Bone Cysts, Aneurysmal / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D005266:Femoral Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D018212:Giant Cell Tumor of Bone / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human