title: Pulmonary toxicity associated with the use of lenalidomide: case report of late-onset acute respiratory distress syndrome and literature review.
abstract: Lenalidomide is an immunomodulating drug structurally similar to thalidomide. It is indicated for patients with relapsing or refractory multiple myeloma in combination with dexamethasone, and for patients with myelodysplastic syndromes associated with a deletion 5q cytogenetic abnormality. It is also used to treat other myelodysplastic syndromes such as myelofibrosis and lymphoma. We report a case of organizing pneumonia leading to acute respiratory distress syndrome (ARDS) after long-term administration of lenalidomide, along with a review of the literature.
authors.affiliation: Service de Pneumologie et Explorations Fonctionnelles Respiratoires, CHRU de Tours, France. Electronic address: karoun@orange.fr.
authors.forename: J
authors.initials: J
authors.lastname: Mankikian
authors.affiliation: Service de Médecine Interne, CHRU de Tours, France.
authors.forename: B
authors.initials: B
authors.lastname: Lioger
authors.affiliation: Service de Médecine Interne, CHRU de Tours, France.
authors.forename: E
authors.initials: E
authors.lastname: Diot
authors.affiliation: Service de Médecine Interne, CHRU de Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: D'Halluin
authors.affiliation: Service d'Hématologie et Thérapie Cellulaire, CHRU de Tours, France.
authors.forename: S
authors.initials: S
authors.lastname: Lissandre
authors.affiliation: Service de Pneumologie et Explorations Fonctionnelles Respiratoires, CHRU de Tours, France.
authors.forename: S
authors.initials: S
authors.lastname: Marchand Adam
authors.affiliation: Service de Réanimation Polyvalente, CHRU de Tours, France.
authors.forename: E
authors.initials: E
authors.lastname: Mercier
authors.affiliation: Service de Pharmacologie Clinique Centre Régional de Pharmacovigilance, CHRU de Tours, France.
authors.forename: F
authors.initials: F
authors.lastname: Beau Salinas
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D000077269:Lenalidomide; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000188:drug therapy; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013792:Thalidomide / Q000009:adverse effects / Q000031:analogs & derivatives*; D014057:Tomography, X-Ray Computed
chemical_list: D007155:Immunologic Factors; D013792:Thalidomide; D000077269:Lenalidomide
keywords: ARDS; Drug toxicity; Lenalidomide