title: High fasting insulin levels and insulin resistance may be linked to idiopathic recurrent pregnancy loss: a case-control study.
abstract: Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred eighteen women divided into case group (with at least two pregnancy losses, earlier than 20 weeks of gestation, and negative for the recurrent pregnancy loss testing) and control group (with at least one live birth, no pregnancy loss). FG (fasting glucose) and FI (fasting insulin) were determined for all patients. IR was evaluated by HOMA-IR index. Results. There were not significant differences between the mean age and BMI in cases and controls (P > 0.05). Fasting glucose was significantly higher in the control group (85.6 versus 79.8 P < 0.01), but fasting insulin (15.24 versus 12.83, P < 0.001) and HOMA-IR (2.98 versus 2.69, P < 0.05) were significantly higher in the case group. Conclusion. In women with idiopathic recurrent pregnancy loss FI and IR are higher than those in women without spontaneous abortion.
authors.affiliation: Astra Clinic, Gr. Alexandrescu Street, No. 1, 550371 Sibiu, Romania.
authors.forename: Corina-Alina
authors.initials: CA
authors.lastname: Ispasoiu
authors.affiliation: Obstetrics and Gynaecology Department, University of Medicine "Victor Papilian", L. Blaga Street, No. 2-4, 550169 Sibiu, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Chicea
authors.affiliation: 1st Obstetrics and Gynaecology Department, University of Medicine and Pharmacy, "Iuliu Hatieganu", Clinicilor Street, No. 1-3, 400006 Cluj-Napoca, Romania.
authors.forename: Florin Vasile
authors.initials: FV
authors.lastname: Stamatian
authors.affiliation: Polisano Clinic, Constitutiei Street, No. 24, 550253 Sibiu, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Ispasoiu