title: Bidirectional conversion of intestinal epithelial cells: NFκB is key.
abstract: NFκB represents a key transcription factor within the inflammatory tumor microenvironment; however, NFκB's function in tumor-initiating cells has not been examined yet. A recent Cell paper by Schwitalla et al. reports that NFκB modulates Wnt signaling and shows that enhanced Wnt activation induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity.
authors.affiliation: Department of Hematology, Oncology, and Clinical Immunology; Heinrich-Heine-University Duesseldorf; Duesseldorf, Germany.
authors.forename: Amelie
authors.initials: A
authors.lastname: Boquoi
mesh_terms: D000818:Animals; D054337:Cell Dedifferentiation; D002471:Cell Transformation, Neoplastic; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology*
keywords: EMT; Lgr5; NFκB; Wnt signaling; chronic inflammation; dedifferentiation; microenvironment