title: [Acute myeloid leukemia with t(11;22) (q23;q11.2): two cases report and literature review].
abstract: OBJECTIVE
  To report two de novo acute myeloid leukemia (AML) patients with t(11;22)(q23;q11.2) and summarize the clinical and biological characteristics.
  
  
  METHODS
  Bone marrow cells morphology, immunophenotype, chromosome karyotype, fluorescence in situ hybridization (FISH), PCR and gene sequencing were performed. Clinical manifestation and routine laboratory tests were analyzed.
  
  
  RESULTS
  The patients were diagnosed as AML-M₂ and AML-M₅ by morphology and immunophenotype results. Both patients carried t(11;22)(q23; q11.2) and one of them carried an additional chromosome abnormality. MLL-SEPTIN5 fusion transcript was identified in two patients by RT-PCR and sequencing. The two patients got hematologic complete remission after induction chemotherapy with daunorubicin, homoharringtonine, and cytarabine (DHA) or daunorubicin and cytarabine (DA). One of them relapsed and died during consolidation therapy with intermediate-dose cytarabine.
  
  
  CONCLUSIONS
  Leukemia with t(11;22)(q23;q11.2) chromosome translocation met the clinical and laboratory manifestations of AML. The MLL-SEPTIN5 fusion transcript was the distinctively biological etiology. Patients with t(11;22)(q23;q11.2) were vulnerable to relapse after conventional chemotherapy and had poor prognosis. Allogeneic hematopoietic stem cell transplantation should be recommended as early as possible.
authors.affiliation: Center of Lu Dao-Pei Hematology·Neoplasm, Hebei Yan Da Hospital, LangFang 065201, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Liu
authors.forename: Wen
authors.initials: W
authors.lastname: Teng
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.forename: Chun-fang
authors.initials: CF
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Chun-rong
authors.initials: CR
authors.lastname: Tong
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic