title: Human papillomavirus oncoproteins and apoptosis (Review).
abstract: The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV-associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor-associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.
authors.affiliation: Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Peiyue
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yue
keywords: apoptosis; human papillomavirus; incorporation; oncoprotein