title: [The role of surgery in early stage small cell lung cancer: should it be re-evaluated?].
abstract: Two historical randomized controlled trials have demonstrated that chemo-radiotherapy offers the best survival advantage over surgery in small cell lung carcinoma (SCLC) and led to abandon surgery for the treatment of SCLC. Yet, widespread use of CT scanning increases the detection of early and very early stage SCLC. Therefore, the traditional 2 stages classification scheme--namely limited and extensive stage disease--is no longer sufficient for such early stage disease and must be completed by the TNM classification. Although randomized controlled trials are lacking, retrospective case series and large population databases suggest a beneficial role of surgery for the earliest SCLC stages. It is thus currently recommended to consider surgery in the multimodal treatment of stage I SCLC.
authors.affiliation: Service de médecine interne générale, Départment de médecine interne, HUG, 1211 Genève 14.
authors.forename: M
authors.initials: M
authors.lastname: Clemente
authors.affiliation: Service de pneumologie, Départment des spécialités de médecine, HUG, 1211 Genève 14.
authors.forename: P M
authors.initials: PM
authors.lastname: Soccal
authors.affiliation: Service de pneumologie, Départment des spécialités de médecine, HUG, 1211 Genève 14.
authors.forename: T
authors.initials: T
authors.lastname: Rochat
authors.affiliation: Service de chirurgie thoracique, Départment de chirurgie, HUG, 1211 Genève 14.
authors.forename: W
authors.initials: W
authors.lastname: Karenovics
authors.affiliation: Service d'oncologie, Départment des spécialités de médecine, HUG, 1211 Genève 14.
authors.forename: N
authors.initials: N
authors.lastname: Mach
authors.affiliation: Service de pneumologie, Départment des spécialités de médecine, HUG, 1211 Genève 14.
authors.forename: D
authors.initials: D
authors.lastname: Adler
mesh_terms: D059248:Chemoradiotherapy / Q000379:methods*; D003131:Combined Modality Therapy; D055088:Early Detection of Cancer; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D055752:Small Cell Lung Carcinoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods