title: Beta2-agonists use during pregnancy and perinatal outcomes: a systematic review.
abstract: BACKGROUND
  Short and long-acting beta2-agonists (SABA and LABA) have a crucial role in asthma management during pregnancy, as stated in the current guidelines.
  
  
  OBJECTIVE
  To systematically review the evidence on beta2-agonists use during pregnancy and adverse perinatal outcomes.
  
  
  METHODS
  Six databases were searched before January 1, 2013 for beta2-agonists use during pregnancy and congenital malformations, small for gestational age, mean and low birth weight, gestational age and preterm delivery. Original English language articles were included with no cut-off date. Quality assessment and post-hoc power calculations were performed.
  
  
  RESULTS
  Twenty-one original studies were identified. Four studies reported a significant increased risk of congenital malformations with SABA, while one study reported a significant decreased risk with high doses of SABA. One study reported a significant increased risk of congenital malformations with LABA and four studies reported a significant increased risk of congenital malformations with beta2-agonists (SABA and/or LABA). One study reported a decrease in birth weight centiles among LABA users.
  
  
  CONCLUSIONS
  All studies reporting significant results, except two, used non-asthmatic women as reference group, making it difficult to differentiate between the effect of the disease from the one of the beta2-agonists. Non-significant results should be interpreted with caution due to the low statistical power of several studies.
  
  
  CONCLUSIONS
  Methodological limitations and lack of power of several studies prevent us to conclude on the perinatal safety of beta2-agonists. Until further evidence is available, physicians should continue prescribing them as recommended in the guidelines whenever needed to attain asthma control.
authors.affiliation: Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
authors.forename: Sherif
authors.initials: S
authors.lastname: Eltonsy
authors.affiliation: Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
authors.forename: Fatima-Zohra
authors.initials: FZ
authors.lastname: Kettani
authors.affiliation: Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada. Electronic address: lucie.blais@umontreal.ca.
authors.forename: Lucie
authors.initials: L
authors.lastname: Blais
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D016896:Treatment Outcome
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D018927:Anti-Asthmatic Agents; D005938:Glucocorticoids
keywords: Asthma; Beta-2-agonists; Birth weight; Congenital defects; Gestational age; Pregnancy