title: Small molecules for cell reprogramming and heart repair: progress and perspective.
abstract: Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical approaches for producing ample supplies of cells, such as pluripotent stem cells and cardiomyocytes, hold promise as practical means to achieve safe, facile cell-based therapy for cardiac repair and regenerative medicine. In this review, we describe recent advances in the application of small molecules to improve the generation and maintenance of pluripotent stem cells. We also describe new directions in heart repair and regeneration in which chemical approaches may find their application.
authors.affiliation: The Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States.
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.forename: Nan
authors.initials: N
authors.lastname: Cao
authors.forename: Sheng
authors.initials: S
authors.lastname: Ding
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000187:drug effects*; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D054852:Small Molecule Libraries