title: [Establishment of the mathematic model of total quantum statistical moment standard similarity for application to medical theoretical research].
abstract: The paper aims to elucidate and establish a new mathematic model: the total quantum statistical moment standard similarity (TQSMSS) on the base of the original total quantum statistical moment model and to illustrate the application of the model to medical theoretical research. The model was established combined with the statistical moment principle and the normal distribution probability density function properties, then validated and illustrated by the pharmacokinetics of three ingredients in Buyanghuanwu decoction and of three data analytical method for them, and by analysis of chromatographic fingerprint for various extracts with different solubility parameter solvents dissolving the Buyanghanwu-decoction extract. The established model consists of four mainly parameters: (1) total quantum statistical moment similarity as ST, an overlapped area by two normal distribution probability density curves in conversion of the two TQSM parameters; (2) total variability as DT, a confidence limit of standard normal accumulation probability which is equal to the absolute difference value between the two normal accumulation probabilities within integration of their curve nodical; (3) total variable probability as 1-Ss, standard normal distribution probability within interval of D(T); (4) total variable probability (1-beta)alpha and (5) stable confident probability beta(1-alpha): the correct probability to make positive and negative conclusions under confident coefficient alpha. With the model, we had analyzed the TQSMS similarities of pharmacokinetics of three ingredients in Buyanghuanwu decoction and of three data analytical methods for them were at range of 0.3852-0.9875 that illuminated different pharmacokinetic behaviors of each other; and the TQSMS similarities (ST) of chromatographic fingerprint for various extracts with different solubility parameter solvents dissolving Buyanghuanwu-decoction-extract were at range of 0.6842-0.999 2 that showed different constituents with various solvent extracts. The TQSMSS can characterize the sample similarity, by which we can quantitate the correct probability with the test of power under to make positive and negative conclusions no matter the samples come from same population under confident coefficient a or not, by which we can realize an analysis at both macroscopic and microcosmic levels, as an important similar analytical method for medical theoretical research.
authors.affiliation: Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
authors.forename: Fu-yuan
authors.initials: FY
authors.lastname: He
authors.affiliation: The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha 410007, China.
authors.forename: Kai-wen
authors.initials: KW
authors.lastname: Deng
authors.affiliation: Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Wen-long
authors.initials: WL
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China.
authors.forename: Ji-lian
authors.initials: JL
authors.lastname: Shi
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D015233:Models, Statistical; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C460102:buyang huanwu