title: Efficacy of silver diamine fluoride as an antibacterial as well as antiplaque agent compared to fluoride varnish and acidulated phosphate fluoride gel: an in vivo study.
abstract: BACKGROUND
  Silver diamine fluoride (SDF) is already proven as an antibacterial agent in vitro. Present study was formulated to compare the efficacy of SDF as an antibacterial as well as antiplaque agent in vivo with fluoride varnish and acidulated phosphate fluoride (APF) gel.
  
  
  METHODS
  Total 123 children (male = 82, female = 41) were included in the study for a period of 18 months. Children were divided into three different groups-Group 1: SDF; Group 2: fluoride varnish; and Group 3: APF gel. All subjects were evaluated via plaque score at 6 th, 12 th, and 18 th months as well as Streptococcus mutans counts in saliva at 72 h, 6 th, 12 th, and 18 th months of follow-up.
  
  
  RESULTS
  Significant reduction was found in plaque score as well as S. mutans counts irrespective of group division. On intergroup comparison, no statistically significant difference was found in plaque score, but significant reduction in S. mutans counts was found in Group 1 as compared with Groups 2 and 3, while no significant difference was found between Groups 2 and 3.
  
  
  CONCLUSIONS
  In vivo application of SDF on enamel significantly decreases S. mutans counts as compared to fluoride varnish and APF gel.
authors.affiliation: Department of Pedodontics and Preventive Dentistry, College of Dental Science and Research Centre, Bopal-Ghuma Road, Manipur, Ahmedabad, Gujarat, India.
authors.forename: Shalin
authors.initials: S
authors.lastname: Shah
authors.forename: Vijay
authors.initials: V
authors.lastname: Bhaskar
authors.forename: Karthik
authors.initials: K
authors.lastname: Venkataraghavan
authors.forename: Prashant
authors.initials: P
authors.lastname: Choudhary
authors.forename: M
authors.initials: M
authors.lastname: Ganesh
authors.forename: Krishna
authors.initials: K
authors.lastname: Trivedi
mesh_terms: D000143:Acids / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003773:Dental Plaque / Q000517:prevention & control*; D005460:Fluorides, Topical; D005782:Gels; D006801:Humans; D010710:Phosphates / Q000008:administration & dosage* / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D018030:Silver Compounds
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D005460:Fluorides, Topical; D005782:Gels; D010710:Phosphates; D000644:Quaternary Ammonium Compounds; D018030:Silver Compounds; C024633:silver diamine fluoride