title: Guaiol--a naturally occurring insecticidal sesquiterpene.
abstract: The dichloromethane fraction of Ferula ferulaeoides was analyzed by GC and GC-MS, and thirty-four compounds were identified. The main component in the fraction, guaiol (37.0%) was separated by chromatographic methods and identified from spectroscopic data, including 1H and 13C NMR, and X-ray crystallographic diffraction. Guaiol showed significant inhibition of aphids at a concentration of 70 mg/L. It also showed good contact activities against the 4th instar larvae of Mythimna separate and 3rd instar larvae of Plutella xylostella, with LD50 values of 0.07 and 8.9 mg/larva, as well as fumigation activity against the 4th instar larvae ofM. separata and adult Musca domestica, with LC50 values of 3.5 microL/L and 16.9 microL/L, respectively.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Plant Protection, Agricultural College of Shihezi University, Xinjiang 832000, China.
authors.forename: Chun-Juan
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Plant Protection, Agricultural College of Shihezi University, Xinjiang 832000, China.
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Xie
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Mu
mesh_terms: D000818:Animals; D005309:Ferula / Q000737:chemistry*; D007313:Insecta; D007306:Insecticides / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000302:isolation & purification*; D045789:Sesquiterpenes, Guaiane
chemical_list: D007306:Insecticides; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C469146:guaiol