title: Kelsoenethiol and dikelsoenyl ether, two unique kelsoane-type sesquiterpenes, from the Formosan soft coral Nephthea erecta.
abstract: Two new kelsoane-type sesquiterpenes, namely kelsoenethiol (1) and dikelsoenyl ether (2), were obtained from the Formosan soft coral Nephthea erecta. Their structures were elucidated through extensive spectroscopic analyses, ESI orbitrap mass and quantum chemical calculations (QCC). The cytotoxicity against A-459 (human lung carcinoma), P-388 (mouse lymphocytic leukemia), and HT-29 (human colon adenocarcinoma) cancer cell lines of 1 and 2 was evaluated in vitro. Compound 1 showed cytotoxicity against P-388 and HT-29 cells with ED50s of 1.3 and 1.8 μg/mL, respectively.
authors.affiliation: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.affiliation: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors.forename: Neng-Lang
authors.initials: NL
authors.lastname: Shih
authors.affiliation: Department of Chemistry, Oakland University, Rochester, MI 48309, USA.
authors.forename: Kuang-Yu
authors.initials: KY
authors.lastname: Hou
authors.affiliation: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors.forename: Mang-Jye
authors.initials: MJ
authors.lastname: Ger
authors.affiliation: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors.forename: Chia-Ning
authors.initials: CN
authors.lastname: Yang
authors.affiliation: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Shang-Kewi
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center of Asia-Pacific Marine Researches, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: yihduh@mail.nsysu.edu.tw.
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D012717:Sesquiterpenes; C469029:kelsoene
keywords: Cytotoxicity; Kelsoane-type sesquiterpenes; Nephthea erecta; Quantum chemical calculations (QCC)