title: The perinucleolar compartment associates with malignancy.
abstract: The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells bothin vitroandin vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, IL 60611, USA ; College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, IL 60611, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, IL 60611, USA.
authors.forename: Sui
authors.initials: S
authors.lastname: Huang
keywords: PNC; cancer; gene expression regulation; nuclear substructure; structure and function