title: The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups.
abstract: Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights and compares the available methods for these transformations.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.affiliation: Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Weiss
keywords: alkynylation; catalytic asymmetric; propargylic alcohol; propargylic amine