title: Health effects of sodium and potassium in humans.
abstract: OBJECTIVE
  Review new articles that clarify the health consequences of changes in dietary sodium and potassium and that characterize adherence to sodium and potassium intake guideline recommendations.
  
  
  RESULTS
  New clinical trials meta-analyses provide additional documentation of the blood pressure (BP) lowering effects of Na reduction and K supplement, with no adverse effects of Na reduction on cholesterol in steady-state settings. BP is the leading preventable risk factor for worldwide mortality and disability-adjusted life years. A preponderance of cohort studies has identified a direct relationship between dietary sodium and cardiovascular disease (CVD), specially stroke, and an inverse relationship between dietary potassium and CVD. However, these studies are of insufficient quality to support firm conclusions. Modeling studies of sodium reduction in the general population have identified an enormous potential for health benefits. Current intake of dietary sodium and potassium fails to meet guideline recommendations.
  
  
  CONCLUSIONS
  There is abundant evidence that a reduction in dietary sodium and increase in potassium intake decreases BP, incidence of hypertension, and morbidity and mortality from CVD. However, there is no credible evidence that existing policies have been effective in achieving population goals for dietary sodium and potassium intake in the USA.
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D005511:Food Handling; D006262:Health; D006801:Humans; D011188:Potassium / Q000378:metabolism* / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D012964:Sodium; D011188:Potassium