title: Chronic myeloproliferative diseases.
abstract: The chronic myeloproliferative disorders are a group of diseases in which there is an increased proliferation of one or more subtypes of myeloid cells; they include essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). In ET and PV the main neurologic manifestations are headaches, dizziness and macro- and microvascular, both venous and arterial, thrombosis and intracranial hemorrhages. Paresthesias and chorea also occur in PV. In PMF neurologic complications are very rare and consist predominantly of spinal cord compression by extramedullary hematopoiesis tissue.
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: João Forjaz
authors.initials: JF
authors.lastname: de Lacerda
authors.affiliation: Department of Neurology, Hospital da Luz, Lisbon, Portugal.
authors.forename: Sofia N
authors.initials: SN
authors.lastname: Oliveira
authors.affiliation: Neurology Service, Department of Neurosciences, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal. Electronic address: jmferro@fm.ul.pt.
authors.forename: José M
authors.initials: JM
authors.lastname: Ferro
mesh_terms: D002908:Chronic Disease; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D011087:Polycythemia Vera / Q000209:etiology*; D055728:Primary Myelofibrosis
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Myeloproliferative disorder; myelofibrosis; polycythemia; thombocythemia; thrombosis