title: Copper/silver-mediated cascade reactions for the construction of 2-sulfonylbenzo[b]furans from trans-2-hydroxycinnamic acids and sodium sulfinates.
abstract: Efficient construction of 2-sulfonylbenzo[b]furans is achieved from readily available trans-2-hydroxycinnamic acids and sodium sulfinates mediated by the CuCl2·2H2O/AgTFA system under mild conditions. This unprecedented synthetic protocol provides expedient access to a series of products in one step via a protodecarboxylation/C-S bond formation/C-O bond formation cascade.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 2 Nanwei Road, Xicheng District, Beijing 100050, P. R. China.
authors.forename: Hong-Shuang
authors.initials: HS
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry*; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D003373:Coumaric Acids; D013441:Sulfinic Acids; D012834:Silver; C085894:2-hydroxycinnamic acid; D003300:Copper; D012964:Sodium