title: Myocardial infarction induces cognitive impairment by increasing the production of hydrogen peroxide in adult rat hippocampus.
abstract: Accumulating clinical evidence has shown a causal relationship between heart diseases and cognitive impairment in clinical, but the underlying mechanism remains unclear. In this study, rats with myocardial infarction (MI) were used to investigate cognition-related synaptic function and proteins. Adult male Wistar rats were subjected to MI by ligating of left anterior descending artery (LAD) and the infarct size of rat heart was measured by 2,3,5-triphenyltetrazoium chloride (TTC) staining. In this study, results showed that compared with control group, long-term potentiation was suppressed in dentate gyrus area, the contents of hydrogen peroxide (H2O2) and malondialdehyde were significantly increased, whereas the Cu/Zn-superoxide dismutase activity and N-methyl-d-aspartate receptor subunit 2B were attenuated in hippocampus of MI rats. Interestingly, it was observed that the PI3K/Akt pathway was activated in MI rats. Therefore, this study suggests that H2O2 plays an important role in cognitive dysfunction induced by MI.
authors.affiliation: Department of Anatomy and Histoembryology, School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Physiology, School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Physiology, School of Medicine, Nankai University, Tianjin 300071, China. Electronic address: zhuoyang@nankai.edu.cn.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D017774:Long-Term Potentiation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009203:Myocardial Infarction / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D006861:Hydrogen Peroxide; D008315:Malondialdehyde; D051057:Proto-Oncogene Proteins c-akt; D016194:Receptors, N-Methyl-D-Aspartate; D013482:Superoxide Dismutase; C121001:NR2B NMDA receptor
keywords: Cognitive impairment; Hippocampus; Hydrogen peroxide; Myocardial infarction