title: The impact of metabolic parameters on the change of pulmonary function in obese patients.
abstract: BACKGROUND
  Ethnic differences exist in the function and distribution of adipose tissue, which influences whole body metabolism, including pulmonary function. The object of this study was to examine the relationships between serum metabolic parameters and pulmonary function in a morbidly obese Asia-Pacific population.
  
  
  METHODS
  One-hundred thirty-seven morbidly obese Chinese patients, aged≥18 years with a body mass index (BMI)>32 kg/m(2) who were being evaluated for bariatric surgery between July 2007 and December 2008, were studied. Cross-sectional associations between serum metabolic parameters, including lipids, glucose, insulin, leptin, and adiponectin levels with forced vital capacity (FVC) and forced expiratory volume in the first second (FEV₁) assessed by spirometry, were analyzed. Multiple regression analyses also were conducted, with age, gender, smoking history, and various anthropometric measurements of obesity as confounders.
  
  
  RESULTS
  Serum adiponectin and HDL cholesterol had a positive correlation with FVC and FEV1. In addition, insulin resistance, determined by the homeostatic model assessment method (HOMA), was negatively correlated with FVC. In the multiple linear regression analysis, only serum adiponectin was significantly correlated with FVC and FEV₁, independent of obesity level.
  
  
  CONCLUSIONS
  Serum adiponectin level was positively and independently associated with pulmonary function in morbidly obese Chinese adults.
authors.affiliation: Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Electronic address: yufeng528@gmail.com.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Wei
authors.affiliation: Section of Respiratory Therapy, Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Huey-Dong
authors.initials: HD
authors.lastname: Wu
authors.affiliation: Department of Psychiatry, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Ph D
authors.initials: PD
authors.lastname: Yung-Chieh Yen
authors.affiliation: Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Chih-Kun
authors.initials: CK
authors.lastname: Huang
authors.affiliation: Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Tai
authors.affiliation: Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Chin-Feng
authors.initials: CF
authors.lastname: Hsuan
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery; D002681:China / Q000208:ethnology; D008076:Cholesterol, HDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000208:ethnology / Q000503:physiopathology* / Q000601:surgery; D011182:Postoperative Care; D014797:Vital Capacity / Q000502:physiology; D055105:Waist Circumference / Q000208:ethnology; D055815:Young Adult
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL
keywords: Adiponectin; Morbid obesity; Pulmonary function test; Visceral Adipose tissue; Waist circumference