title: A new light on an old disease: adhesion signaling in pemphigus vulgaris.
abstract: Disruption of desmosomal cadherin adhesion leads to the activation of intracellular signaling pathways that are responsible for blister formation in pemphigus vulgaris (PV). Recent studies corroborate the implication of the p38 mitogen-activated protein kinase in PV blistering via its downstream effector mitogen-activated protein kinase activated protein kinase 2. These insights highlight the key role of cadherins in tissue homeostasis and are expected to change pemphigus management.
authors.affiliation: Vetsuisse Faculty, Molecular Dermatology and Stem Cell Research, Institute of Animal Pathology, University Hospital of Bern, Bern, Switzerland; DermFocus University of Bern, University Hospital of Bern, Bern, Switzerland.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Galichet
authors.affiliation: DermFocus University of Bern, University Hospital of Bern, Bern, Switzerland; Department of Dermatology, University Hospital of Bern, Bern, Switzerland.
authors.forename: Luca
authors.initials: L
authors.lastname: Borradori
authors.affiliation: Vetsuisse Faculty, Molecular Dermatology and Stem Cell Research, Institute of Animal Pathology, University Hospital of Bern, Bern, Switzerland; DermFocus University of Bern, University Hospital of Bern, Bern, Switzerland. Electronic address: eliane.mueller@vetsuisse.unibe.ch.
authors.forename: Eliane J
authors.initials: EJ
authors.lastname: Müller
mesh_terms: D000818:Animals; D001768:Blister / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D015603:Keratinocytes / Q000201:enzymology*; D010392:Pemphigus / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D000099190:MAP-Kinase-Activated Kinase 2