title: Molecular markers for prostate cancer in formalin-fixed paraffin-embedded tissues.
abstract: Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. Although this approach leads to a confident diagnosis in most cases, it can be improved by using the molecular markers present in the tissue. Both miRNAs and proteins are considered excellent candidates for biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues, due to their stability over long periods of time. In the last few years, a concerted effort has been made to develop the necessary tools for their reliable measurement in these types of samples. Furthermore, the use of these kinds of markers may also help in establishing tumor grade and aggressiveness, as well as predicting the possible outcomes in each particular case for the different treatments available. This would aid clinicians in the decision-making process. In this review, we attempt to summarize and discuss the potential use of microRNA and protein profiles in FFPE tissue samples as markers to better predict PCa diagnosis, progression, and response to therapy.
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Tamara
authors.initials: T
authors.lastname: Sequeiros
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: García
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Melania
authors.initials: M
authors.lastname: Montes
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Oliván
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Rigau
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Colás
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: de Torres
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Morote
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Reventós
authors.affiliation: Research Unit in Biomedicine and Translational Oncology, Research Institute Vall Hebron University Hospital (VHIR) and Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
authors.forename: Andreas
authors.initials: A
authors.lastname: Doll
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001706:Biopsy; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D016612:Paraffin Embedding; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D016707:Tissue Fixation
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs