title: Neurologic complications of vaccinations.
abstract: This chapter reviews the most common neurologic disorders associated with common vaccines, evaluates the data linking the disorder with the vaccine, and discusses the potential mechanism of disease. A literature search was conducted in PubMed using a combination of the following terms: vaccines, vaccination, immunization, and neurologic complications. Data were also gathered from publications of the American Academy of Pediatrics Committee on Infectious Diseases, the World Health Organization, the US Centers for Disease Control and Prevention, and the Vaccine Adverse Event Reporting System. Neurologic complications of vaccination are rare. Many associations have been asserted without objective data to support a causal relationship. Rarely, patients with a neurologic complication will have a poor outcome. However, most patients recover fully from the neurologic complication. Vaccinations have altered the landscape of infectious disease. However, perception of risk associated with vaccinations has limited the success of disease eradication measures. Neurologic complications can be severe, and can provoke fear in potential vaccines. Evaluating whether there is causal link between neurologic disorders and vaccinations, not just temporal association, is critical to addressing public misperception of risk of vaccination. Among the vaccines available today, the cost-benefit analysis of vaccinations and complications strongly argues in favor of vaccination.
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Augusto A
authors.initials: AA
authors.lastname: Miravalle
authors.affiliation: Department of Neurology, Children's Hospital, Aurora, CO, USA. Electronic address: schreiner.teri@tchdenver.org.
authors.forename: Teri
authors.initials: T
authors.lastname: Schreiner
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects; D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology*; D014611:Vaccination / Q000009:adverse effects*; D014612:Vaccines / Q000009:adverse effects*; D014765:Viral Vaccines / Q000009:adverse effects
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D014612:Vaccines; D014765:Viral Vaccines
keywords: ADEM; Vaccination; demyelination; encephalitis; postinfectious encephalomyelitis; postvaccinal encephalomyelitis