title: Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases.
abstract: BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25-76ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.
authors.affiliation: National Atomic Energy Commission, Argentina; National Research Council (CONICET), Argentina.
authors.forename: V A
authors.initials: VA
authors.lastname: Trivillin
authors.affiliation: National Atomic Energy Commission, Argentina.
authors.forename: M A
authors.initials: MA
authors.lastname: Garabalino
authors.affiliation: National Research Council (CONICET), Argentina; Oncology Institute Angel H. Roffo, Argentina; CAECIHS-UAI, Argentina.
authors.forename: L L
authors.initials: LL
authors.lastname: Colombo
authors.affiliation: National Atomic Energy Commission, Argentina; National Research Council (CONICET), Argentina.
authors.forename: S J
authors.initials: SJ
authors.lastname: González
authors.affiliation: National Atomic Energy Commission, Argentina.
authors.forename: R O
authors.initials: RO
authors.lastname: Farías
authors.affiliation: National Atomic Energy Commission, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Monti Hughes
authors.affiliation: National Atomic Energy Commission, Argentina.
authors.forename: E C C
authors.initials: EC
authors.lastname: Pozzi
authors.affiliation: Dipartimento di Fisica Nucleare e Teorica dell' Università, Pavia and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bortolussi
authors.affiliation: Dipartimento di Fisica Nucleare e Teorica dell' Università, Pavia and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Altieri
authors.affiliation: National Atomic Energy Commission, Argentina; Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Argentina.
authors.forename: M E
authors.initials: ME
authors.lastname: Itoiz
authors.affiliation: National Atomic Energy Commission, Argentina; Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Argentina.
authors.forename: R F
authors.initials: RF
authors.lastname: Aromando
authors.affiliation: Idaho National Laboratory, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Nigg
authors.affiliation: National Atomic Energy Commission, Argentina; National Research Council (CONICET), Argentina. Electronic address: mandyschwint@gmail.com.
authors.forename: A E
authors.initials: AE
authors.lastname: Schwint
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D045744:Cell Line, Tumor; D004338:Drug Combinations; D008175:Lung Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary*; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011879:Radiotherapy Dosage; D051381:Rats; D014018:Tissue Distribution
chemical_list: D001896:Boron Compounds; D004338:Drug Combinations; C569622:decahydrodecaborate; D010649:Phenylalanine; C033685:4-boronophenylalanine
keywords: BNCT; BPA; Boron Neutron Capture Therapy; Boron biodistribution studies; GB-10; Lung metastases