title: P2X receptors in neuroglia.
abstract: Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca2+and Na+concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X4and P2X7receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Manchester, UK ; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain ; Department of Neurosciences, University of the Basque Country UPV/EHU, Leioa, Spain.
authors.forename: Alexei
authors.initials: A
authors.lastname: Verkhratsky
authors.affiliation: School of Life Sciences, University of Warwick, Coventry, UK.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Pankratov
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Manchester, UK.
authors.forename: Ulyana
authors.initials: U
authors.lastname: Lalo
authors.affiliation: Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Maiken
authors.initials: M
authors.lastname: Nedergaard