title: Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: combined administration of BSH and BPA.
abstract: Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina.
authors.forename: Marcela A
authors.initials: MA
authors.lastname: Garabalino
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina.
authors.forename: Elisa M
authors.initials: EM
authors.lastname: Heber
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina.
authors.forename: Andrea
authors.initials: A
authors.lastname: Monti Hughes
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina.
authors.forename: Emiliano C C
authors.initials: EC
authors.lastname: Pozzi
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina.
authors.forename: Ana J
authors.initials: AJ
authors.lastname: Molinari
authors.affiliation: Idaho National Laboratory, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Nigg
authors.affiliation: Idaho National Laboratory, USA.
authors.forename: William
authors.initials: W
authors.lastname: Bauer
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina; National Research Council (CONICET), Argentina.
authors.forename: Verónica A
authors.initials: VA
authors.lastname: Trivillin
authors.affiliation: National Atomic Energy Commission (CNEA), Argentina; National Research Council (CONICET), Argentina. Electronic address: schwint@cnea.gov.ar.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Schwint
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001896:Boron Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002610:Cheek; D006224:Cricetinae; D004338:Drug Combinations; D008647:Mesocricetus; D008657:Metabolic Clearance Rate; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D009928:Organ Specificity; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011879:Radiotherapy Dosage; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D001894:Borohydrides; D001896:Boron Compounds; D004338:Drug Combinations; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D010649:Phenylalanine; C033685:4-boronophenylalanine
keywords: BNCT; BPA; BSH; Boron Neutron Capture Therapy; Hamster cheek pouch oral cancer model; Oral cancer