title: Exenatide-induced eosinophilic sclerosing lipogranuloma at the injection site.
abstract: Sclerosing lipogranuloma is a granulomatous reaction to the injection of a high-viscosity fluid in the tissues for the cosmetic purpose of improving body contour; lesions on the extremities and buttocks are commonly the results of injections of therapeutic agents in oily vehicles. Exenatide, once-weekly injection, is a therapeutic method for patients with type 2 diabetes. Here, we describe a case of exenatide once weekly induced eosinophilic sclerosing lipogranuloma at the injection site of a 62-year-old patient. To the best of our knowledge, the histopathologic features of this adverse event have not been reported in the medical literature.
authors.affiliation: *Ackerman Academy of Dermatopathology, New York, NY; and †Department of Dermatology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Shan
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D000077270:Exenatide; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D015434:Panniculitis / Q000139:chemically induced* / Q000473:pathology; D010455:Peptides / Q000008:administration & dosage / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D014688:Venoms / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms; D000077270:Exenatide