title: In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 Gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China.
abstract: Ceftazidime-avibactam, aztreonam-avibactam, and comparators were tested by reference broth microdilution against 372 nonrepetitive Gram-negative bacilli (346 unselected plus 26 selected meropenem-nonsusceptible Enterobacteriaceae isolates) collected from 11 teaching hospitals in China in 2011 and 2012. Meropenem-nonsusceptible isolates produced extended-spectrum β-lactamases (ESBLs; e.g., CTX-M-14/3), AmpCs (e.g., CMY-2), and/or carbapenemases (e.g., KPC-2 and NDM-1). Avibactam potentiated the activity of ceftazidime against organisms with combinations of ESBLs, AmpCs, and KPC-2. Aztreonam-avibactam was active against all β-lactamase producers (including producers of NDM-1 and IMP-4/8) except blaOXA-containing Acinetobacter baumannii and some Pseudomonas aeruginosa isolates.
authors.affiliation: Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wang
authors.forename: Feifei
authors.initials: F
authors.lastname: Zhang
authors.forename: Chunjiang
authors.initials: C
authors.lastname: Zhao
authors.forename: Zhanwei
authors.initials: Z
authors.lastname: Wang
authors.forename: Wright W
authors.initials: WW
authors.lastname: Nichols
authors.forename: Raymond
authors.initials: R
authors.lastname: Testa
authors.forename: Henan
authors.initials: H
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Chen
authors.forename: Wenqiang
authors.initials: W
authors.lastname: He
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D053961:Azabicyclo Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology*; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006784:Hospitals, Teaching; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D053961:Azabicyclo Compounds; D004338:Drug Combinations; C543519:avibactam; D002442:Ceftazidime; D001618:beta-Lactamases; D001398:Aztreonam