title: Darunavir and telaprevir drug interaction: total and unbound plasma concentrations in HIV/HCV-coinfected patients with cirrhosis.
authors.affiliation: Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Adrian
authors.initials: A
authors.lastname: Curran
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Guiu
authors.forename: Esteban
authors.initials: E
authors.lastname: Ribera
authors.forename: Manuel
authors.initials: M
authors.lastname: Crespo
mesh_terms: D000998:Antiviral Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000069454:Darunavir; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010949:Plasma / Q000737:chemistry; D013449:Sulfonamides / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D009842:Oligopeptides; D013449:Sulfonamides; C486464:telaprevir; D000069454:Darunavir
keywords: antiretroviral treatment; hepatic cirrhosis; pharmacokinetics