title: PSA levels in patients on hemodialysis treatment.
abstract: OBJECTIVE
  Standardized prostate-specific antigen (PSA) levels are based upon the general population levels and, although a higher incidence of prostate cancer in patients on hemodialysis (HD)has not been demonstrated, some studies point at the possibility of observing higher PSA levels in this type of patients than in males with preserved renal function. The objective of the present study is to compare PSA levels in males on hemodialysis with those of the population with normal renal function.
  
  
  METHODS
  Comparative, transversal study of the variables age, total PSA, free PSA and PSA index in 190 patients with chronic renal disease on hemodialysis treatment (group 1) and 237 subjects without renal disease ( group 2). We carried out a descriptive analysis and a comparative study of the above mentioned variables using the SPSS software.
  
  
  RESULTS
  Median age of patients on HD was 55 in cases (47-61)and 59 in controls (54-63.5). Mean total PSA was 1.49 ng/mL [1.24-1.73] in cases and 1.62 ng/mL [1.29-1.95] in controls; mean free PSA was 1.40 ng/mL [0.89-1.91] in group 1 and 2.31 ng/mL [-0.83-5.45] in group 2; mean PSA index was 27.67% [19.91-35.63] in cases and 14.82%[12.79-16.85]] in controls. The comparative study showed differences between the two groups in free PSA (p ≤ 0.007), PSA index (p ≤ 0.000) and total PSA (p ≤ 0.000) in patients under 50 after an age-specific analysis.
  
  
  CONCLUSIONS
  Total PSA is higher in patients on HD within the subgroup of patients under 50 with statistically significant but not clinically relevant difference. PSA index is remarkably higher in the group of patients on HD. These data could have clinical implications as far as indications for biopsy is concerned.
authors.affiliation: Urology Department.Hospital Universitario Virgen del Rocio. Sevilla.Spain.
authors.forename: C
authors.initials: C
authors.lastname: García-Sánchez
authors.forename: C
authors.initials: C
authors.lastname: Corchuelo-Maillo
authors.forename: C B
authors.initials: CB
authors.lastname: Congregado-Ruiz
authors.forename: E M
authors.initials: EM
authors.lastname: Ocón-Revuelta
authors.forename: I
authors.initials: I
authors.lastname: Osman-García
authors.forename: J M
authors.initials: JM
authors.lastname: Conde-Sánchez
authors.forename: R A
authors.initials: RA
authors.lastname: Medina-López
mesh_terms: D001706:Biopsy; D006801:Humans; D007676:Kidney Failure, Chronic; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms; D006435:Renal Dialysis
chemical_list: D017430:Prostate-Specific Antigen