title: NF-κB control of T cell development.
abstract: The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals.
authors.affiliation: The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.
authors.forename: Steve
authors.initials: S
authors.lastname: Gerondakis
authors.affiliation: The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Fulford
authors.affiliation: The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Messina
authors.affiliation: The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.
authors.forename: Raelene J
authors.initials: RJ
authors.lastname: Grumont
mesh_terms: D019070:Cell Lineage / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D016328:NF-kappa B / Q000276:immunology* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D060168:Thymocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell