title: Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine.
abstract: In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (HA) on etched dentine, and the regenerated HA has a similar crystal structure with natural dentine. It can also release the encapsulated triclosan for a long period. The interesting drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree, which are ideal to obtain multifunctional properties of long-term release of anti-bacterial drug for local treatment during the remineralization process. The triclosan-loaded G4-COOH provides a general strategy to cure dental caries and repair damaged dentine at the same time, which forms a potential restorative material for dental repair.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Zaifu
authors.initials: Z
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Kunneng
authors.initials: K
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: He
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: lisheyu@gmail.com.
authors.forename: Sheyu
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China. Electronic address: jianshu_li@scu.edu.cn.
authors.forename: Jianshu
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011073:Polyamines / Q000737:chemistry / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D014089:Tooth Remineralization; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D050091:Dendrimers; C531249:Poly(amidoamine); D011073:Polyamines; D012996:Solutions; D014260:Triclosan; D017886:Durapatite
keywords: Dendrimer; Drug release; Human dentine; Remineralization; Triclosan