title: In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel.
abstract: BACKGROUND
  The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic evaluation of the formulation.
  
  
  METHODS
  The gel was prepared by using carbopol 934 as gelling agent and methyl paraben as a preservative in an Aloe vera gel base. The formulated gel was also evaluated for physicochemical parameters like pH, viscosity, drug content, and in vitro diffusion assessment. Pharmacodynamic activity of the formulation was evaluated in Wistar albino rats. The formulated gel was compared with that of similar marketed gel (commercial piroxicam gel (CPG)) against the same parameters.
  
  
  RESULTS
  From in vitro studies, an effective drug release from PAG was observed to be 68.17% when compared with that of the CPG (62.71%) at 180 min indicating better drug release from the gel formulated in this study. Percentage inhibition of edema was greater for the preparation of PAG (29.57 mean percent inhibition after 60 min) compared to marketed gel which exhibited 18.3% after 60 min.
  
  
  CONCLUSIONS
  It was concluded from the results that the Aloe vera gel acts as an effective gel base to prepare piroxicam gel with high drug loading capacity and improved anti-inflammatory effect. From the statistical analysis the formulation of PAG showed better release than the CPG at p < 0.05 level of significance.
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Vinesha
authors.initials: V
authors.lastname: Velam
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Prasanna Raju
authors.initials: PR
authors.lastname: Yalavarthi
authors.affiliation: Department of Medicine, Faculty of Medicine, University College Sedaya International University, Kuala Lumpur, Malaysia.
authors.forename: Cr
authors.initials: C
authors.lastname: Sundaresan
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Kr
authors.initials: K
authors.lastname: Vandana
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Thushara Bindu
authors.initials: TB
authors.lastname: Dudala
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Haritha
authors.initials: H
authors.lastname: Kodavatikanti
authors.affiliation: Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
authors.forename: Harini Chowdary
authors.initials: HC
authors.lastname: Vadlamudi
keywords: % inhibition; Aloe vera; carbopol 934; edema; flux; in vitro diffusion; pharmacodynamic activity; piroxicam