title: H(3)PW(12)O(40)-catalyzed multicomponent reaction for efficient synthesis of highly substituted piperidines.
abstract: A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.
authors.forename: Samad
authors.initials: S
authors.lastname: Khaksar
authors.forename: Seyed Meysam
authors.initials: SM
authors.lastname: Baghbanian
authors.affiliation: Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.. Samadkhaksar@yahoo.com.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Barsan
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters / Q000737:chemistry; D010772:Phosphotungstic Acid / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; D004952:Esters; D011725:Pyridines; D010772:Phosphotungstic Acid; C023650:aniline