title: The prognosis and treatment outcomes of patients with recurrent hepatocellular carcinoma after liver transplantation.
abstract: Liver transplantation (LT) is performed in patients with hepatocellular carcinoma (HCC), but recurrent HCC after LT remains a problem. We retrospectively reviewed the data from 63 patients with recurrent HCC who underwent LT at a single institution between September 1996 and March 2011 to determine the prognosis of patients with recurrent HCC after LT. A survival analysis was performed with the preoperative data, histological findings, patterns of recurrence, and treatment methods. Univariate and multivariate analyses were performed to determine the factors associated with early (<1 yr) cancer-related death. The independent prognostic factors, according to the multivariate analysis, were recurrence within six months (hazards ratio [HR] = 4.557, p = 0.021) and initial multiple-organ involvement (HR = 5.494, p = 0.015). The survival rates of patients differed according to the treatment type. The combined treatment with local and systemic treatment resulted in increased survival even in patients with HCC recurrences involving multiple organs.
authors.affiliation: Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
authors.forename: Young-Nam
authors.initials: YN
authors.lastname: Roh
authors.forename: Choon Hyuck
authors.initials: CH
authors.lastname: David Kwon
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Song
authors.forename: Milljae
authors.initials: M
authors.lastname: Shin
authors.forename: Jong
authors.initials: J
authors.lastname: Man Kim
authors.forename: Sungjoo
authors.initials: S
authors.lastname: Kim
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Joh
authors.forename: Suk-Koo
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
keywords: locoregional treatment; mTOR inhibitor; metastasis; rapamycin; sorafenib