title: Novel faces of heme oxygenase-1: mechanisms and therapeutic potentials.
abstract: Not only double, Janus face, but numerous appearances characterize heme oxygenase-1 (HO-1), an inducible enzyme which main role is to degrade heme. Recently, the noncanonical functions of HO-1 have particularly attracted researchers' attention. Indeed, understanding the enzyme-independent activities of HO-1 can provide additional chances for translational application of research on HO-1. In this Forum, eight reviews and two original articles describe a plethora of mechanisms in which this pleiotropic protein is involved. Further understanding of HO-1 functions is of particular significance for elucidating the pathology of various human diseases and providing rationale for novel therapies.
authors.affiliation: Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Krakow, Poland .
authors.forename: Jozef
authors.initials: J
authors.lastname: Dulak
authors.forename: Alicja
authors.initials: A
authors.lastname: Jozkowicz
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D051547:Heme Oxygenase-1 / Q000502:physiology*; D006801:Humans; D009136:Muscular Dystrophies / Q000188:drug therapy / Q000201:enzymology; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000201:enzymology
chemical_list: D051547:Heme Oxygenase-1