title: The function of the respiratory supercomplexes: the plasticity model.
abstract: Mitochondria are important organelles not only as efficient ATP generators but also in controlling and regulating many cellular processes. Mitochondria are dynamic compartments that rearrange under stress response and changes in food availability or oxygen concentrations. The mitochondrial electron transport chain parallels these rearrangements to achieve an optimum performance and therefore requires a plastic organization within the inner mitochondrial membrane. This consists in a balanced distribution between free respiratory complexes and supercomplexes. The mechanisms by which the distribution and organization of supercomplexes can be adjusted to the needs of the cells are still poorly understood. The aim of this review is to focus on the functional role of the respiratory supercomplexes and its relevance in physiology. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components.
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro, 3, 28029 Madrid, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Acin-Perez
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro, 3, 28029 Madrid, Spain. Electronic address: jaenriquez@cnic.es.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Enriquez
mesh_terms: D019069:Cell Respiration; D045304:Cytochromes c / Q000378:metabolism; D004579:Electron Transport; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D017382:Reactive Oxygen Species; D014451:Ubiquinone; D045304:Cytochromes c
keywords: Metabolism; Mitochondrial supercomplex; OXPHOS; Respirasome