title: Primary cutaneous anaplastic large-cell lymphoma--case report.
abstract: Primary cutaneous anaplastic large-cell lymphoma is part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination may occur, especially to regional lymph nodes. Histology shows a diffuse, non-epidermotropic infiltrate , anaplastic large lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is good and does not depend on lymphatic invasion. Radiotherapy, removal of the lesion and/or low-dose methotrexate are the treatments of choice. The present study reports the case of a 57-year-old-woman presenting Primary cutaneous anaplastic large-cell lymphoma with multifocal lesions. The patient evolved with pulmonary involvement 7 years later. She showed a good response to the treatment with low-dose methotrexate prescribed weekly.
authors.affiliation: Federal University of Campina Grande, Campina GrandePB, Brazil.
authors.forename: Luciana Silveira Rabello de
authors.initials: LS
authors.lastname: Oliveira
authors.affiliation: Center for Endocrinology and Metabolism, Campina GrandePB, Brazil.
authors.forename: Madeleyne Palhano
authors.initials: MP
authors.lastname: Nobrega
authors.affiliation: Federal University of Campina Grande, University Hospital Alcides Carneiro, Campina GrandePB, Brazil.
authors.forename: Maira Gomes
authors.initials: MG
authors.lastname: Monteiro
authors.affiliation: Campinense Unit of Diagnosis, Campina GrandePB, Brazil.
authors.forename: Wagner Leite de
authors.initials: WL
authors.lastname: Almeida
mesh_terms: D001706:Biopsy; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000188:drug therapy / Q000473:pathology*; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011859:Radiography; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate