title: [The neural mechanisms of cigarette craving and self-control].
abstract: A craving for cigarettes or drugs has been believed to be a fundamental psychopathological factor that drives drug-seeking behavior and relapse. Behavioral economics has revealed context-dependent changes in drug craving. Neuroimaging studies have also found craving-related signals that were altered depending on the context of the experiments. A rational decision-making theory modeled such context-dependency and uncovered a pivotal role of the prefrontal cortical circuit in both self-control and craving. Future studies should address how dopaminergic function and stress circuits can modify the function of decision-making circuits, and produce either craving or self-control.
authors.affiliation: RIKEN Center for Life Science Technologies (CLST), Functional Architecture Imaging Unit.
authors.forename: Takuya
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D016739:Behavior, Addictive / Q000503:physiopathology*; D058999:Drug-Seeking Behavior / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D055502:Secondary Prevention; D012907:Smoking / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology*