title: Stimuli-induced release of compounds from elastin biomimetic matrix.
abstract: Stimuli-responsive hydrogel matrices have attracted great attention in biomedical and biotechnological fields for controlled delivery of bioactive compounds, as well as a vehicle for therapeutic cell spreading. Elastin-derived biomimetic polypeptides are recombinant macromolecules suitable for the realization of smart biomaterials. In this study, we explored the potential of an elastin biomimetic matrix to realize proteolytic stimuli-responsive systems to control the release of substances. Our approach showed that this matrix was susceptible to elastolytic degradation, and it has been successfully employed to obtain an efficient delivery of a model protein. This setup will constitute a therapeutic agent delivery platform to realize devices capable of responding and interacting with biological systems at the molecular level.
authors.affiliation: Department of Life Sciences, University of Trieste , 34127 Trieste, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Bandiera
authors.forename: Ana
authors.initials: A
authors.lastname: Markulin
authors.forename: Lucia
authors.initials: L
authors.lastname: Corich
authors.forename: Francesca
authors.initials: F
authors.lastname: Vita
authors.forename: Violetta
authors.initials: V
authors.lastname: Borelli
authors.forename: Violetta
authors.initials: V
authors.lastname: Borrelli
mesh_terms: D000595:Amino Acid Sequence; D032701:Biomimetics / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004549:Elastin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa / Q000378:metabolism
chemical_list: D004549:Elastin