title: Evaluating the hemodynamical response of a cardiovascular system under support of a continuous flow left ventricular assist device via numerical modeling and simulations.
abstract: Dilated cardiomyopathy is the most common type of the heart failure which can be characterized by impaired ventricular contractility. Mechanical circulatory support devices were introduced into practice for the heart failure patients to bridge the time between the decision to transplant and the actual transplantation which is not sufficient due to the state of donor organ supply. In this study, the hemodynamic response of a cardiovascular system that includes a dilated cardiomyopathic heart under support of a newly developed continuous flow left ventricular assist device--Heart Turcica Axial--was evaluated employing computer simulations. For the evaluation, a numerical model which describes the pressure-flow rate relations of Heart Turcica Axial, a cardiovascular system model describing the healthy and pathological hemodynamics, and a baroreflex model regulating the heart rate were used. Heart Turcica Axial was operated between 8000 rpm and 11,000 rpm speeds with 1000 rpm increments for assessing the pump performance and response of the cardiovascular system. The results also give an insight about the range of the possible operating speeds of Heart Turcica Axial in a clinical application. Based on the findings, operating speed of Heart Turcica Axial should be between 10,000 rpm and 11,000 rpm.
authors.affiliation: Department of Mechanical Engineering, Yeditepe University, 34755 Kadikoy, Istanbul, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Bozkurt
authors.affiliation: Department of Mechanical Engineering, Yeditepe University, 34755 Kadikoy, Istanbul, Turkey.
authors.forename: Koray K
authors.initials: KK
authors.lastname: Safak
mesh_terms: D000465:Algorithms; D001021:Aortic Valve / Q000473:pathology; D001794:Blood Pressure; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002319:Cardiovascular System; D003198:Computer Simulation; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D013314:Stress, Mechanical