title: [Biomarkers in endocrinology].
abstract: TSH assay is the best parameter of the thyroid function. For adults, the normal interval of TSH concentrations range from 0.4 to 4 mUI/L. At the first trimester of pregnancy, TSH levels must be <2.5 mUI/L. Normal TSH levels increase with aging and obesity. The biological diagnosis relies on the identification of excessive secretion of the metanephrines which are more sensitive and specific than those of catecholamines. The concentrations of the free plasmatic metanephrines reflect the ongoing production of tumor. Plasma methoxytyramine is a novel biomarker of metastatic pheochromocytomas and paragangliomas. Serum IGF1 is a reliable measure of integrated GH concentrations in patients with acromegaly. Accurate assessment of IGF1 concentrations requires age and sex-matched control values. IGF1 is a sensitive tool for the diagnosis of acromegaly and efficacy of therapies. Serum AMH assay is more sensitive, more specific and more reproducible that counting of ovarian follicles by ultrasound. AMH level above 5 ng/mL (35 pmol/L) could be chosen as one of the diagnostic criteria for the polycystic ovary syndrome. In early or "incipiens" ovarian failure, the decrease in serum AMH is far ahead of the increase in FSH. Thyroglobulin (TG) and calcitonin (CT) are the sensitive and specific markers of respectively well-differentiated thyroid cancers of follicular origin and of the medullary thyroid cancers. The same tumour marker assay should be used to monitor a given patient. Chromogranin A (CgA) is a highly efficient biomarker for diagnosis and follow-up of various endocrine tumours. Despite the lack of international standardisation, some CgA assays are reliable.
authors.affiliation: Université de Lille II, 59800 Lille, France; CHRU de Lille, centre de biologie-pathologie-génétique, rue Émile-Laine, 59037 Lille cedex, France. Electronic address: m-dherbomez@chru-lille.fr.
authors.forename: Michèle
authors.initials: M
authors.lastname: d'Herbomez
authors.affiliation: Clinique d'endocrinologie Marc-Linquette, hôpital Huriez, 59037 Lille cedex, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bauters
authors.affiliation: Clinique d'endocrinologie Marc-Linquette, hôpital Huriez, 59037 Lille cedex, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Cortet-Rudelli
authors.affiliation: Université de Lille II, 59800 Lille, France; Hôpital Jeanne-de-Flandre, service de gynécologie endocrinienne et médecine de la reproduction, 59037 Lille cedex, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Dewailly
authors.affiliation: Clinique d'endocrinologie Marc-Linquette, hôpital Huriez, 59037 Lille cedex, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Docao
authors.affiliation: Université de Lille II, 59800 Lille, France; Clinique d'endocrinologie Marc-Linquette, hôpital Huriez, 59037 Lille cedex, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Wémeau
mesh_terms: D015415:Biomarkers / Q000097:blood*; D004704:Endocrinology / Q000379:methods*; D006801:Humans; D013959:Thyroid Diseases / Q000175:diagnosis*
chemical_list: D015415:Biomarkers