title: Use of click-chemistry in the development of peptidomimetic enzyme inhibitors.
abstract: Cu(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) is often utilized in medicinal chemistry to make the triazole moiety as it acts as a non-classical bioisostere of the peptide bond. This useful technique can also be applied in the fragment-based assembly of molecular libraries for high-throughput screening. This minireview outlines the application of click-chemistry in the synthesis of enzyme inhibitors with the triazole moiety.
authors.forename: P
authors.initials: P
authors.lastname: Fabbrizzi
authors.forename: G
authors.initials: G
authors.lastname: Menchi
authors.forename: A
authors.initials: A
authors.lastname: Guarna
authors.affiliation: Department of Chemistry "Ugo Schiff" , University of Florence, via della Lastruccia 13, I-50019 Sesto Fiorentino, Florence, Italy. andrea.trabocchi@unifi.it.
authors.forename: A
authors.initials: A
authors.lastname: Trabocchi
mesh_terms: D055162:Biocatalysis; D057930:Click Chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D057786:Peptidomimetics / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D057786:Peptidomimetics