title: Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice.
abstract: In this study, the chemoprotective effects of Ganoderma atrum polysaccharide (PSG-1) in cyclophosphamide (Cy) treated mice were investigated. In Cy-treated mice, PSG-1 treatment accelerated recovery dose-dependently of peripheral red blood cells, white blood cells and platelets, enhanced splenic natural killer cell activity and cytotoxic T lymphocyte activity. In addition, PSG-1 elevated CD4(+) T lymphocyte counts as well as the CD4(+)/CD8(+) ratio dose-dependently. Furthermore, PSG-1 restored the levels of IL-2, INF-γ, IL-10, IgA, IgM and IgG, as well as hemolysin in the sera. Finally, PSG-1 can also significantly increase the total antioxidant capacity, activities of superoxidase dismutase, catalase and glutathione peroxidase, and decrease the malondialdehyde level in vivo. These findings indicate that PSG-1 plays an important role in the protection against myelosuppression and immunosuppression and oxidative stress in Cy-treated mice and could be a potential immunomodulatory agent.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: spnie@ncu.edu.cn.
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Jun-Qiao
authors.initials: JQ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Dan-Fei
authors.initials: DF
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: De-Ming
authors.initials: DM
authors.lastname: Gong
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: myxie@ncu.edu.cn.
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000633:toxicity; D016207:Cytokines / Q000097:blood; D005260:Female; D062610:Fungal Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D032902:Ganoderma / Q000737:chemistry*; D006410:Hematopoiesis / Q000187:drug effects; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010641:Phenotype; D020011:Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; D016207:Cytokines; D062610:Fungal Polysaccharides; D007136:Immunoglobulins; D007155:Immunologic Factors; D020011:Protective Agents; D003520:Cyclophosphamide
keywords: Chemoprotective effects; Cyclophosphamide; Ganoderma atrum polysaccharide