title: Fertility sparing treatment in young patients with early endometrial adenocarcinoma: case series.
abstract: OBJECTIVE
  The aim of this study was to evaluate fertility-sparing therapy in young patients with endometrial carcinoma.
  
  
  METHODS
  This prospective study was carried out on 8 patients with clinical and radio-graphic stage IA, well differentiated endometrioid adenocarcinoma of the endometrium in Alzahra hospital, Tabriz, Iran. Treatment comprised high-dose megestrol acetate. Dilatation and curettage was repeated every three months.
  
  
  RESULTS
  The mean age of the patients was 30 (SD,3.21) years (range 24-35). Of the 8 patients, 7 (87.5%) achieved complete response. The mean time to response was 6.5 months (range 3-9). Of the complete responders, 3 of 7(42.8%) had recurrence; one patient underwent immediate hysterectomy, and 2 were successfully treated with second-line therapy and both subsequently conceived. Conception occurred in 3 of 7 patients (42.8%), in two more than once, However successful pregnancy occurred only in two patients. One patient developed Concomitant ovarian adenocarcinoma.
  
  
  CONCLUSIONS
  High dose progestin therapy can be an effective fertility-sparing treatment in young patients with well differentiated stage IA endometrial endometrioid cancer confined to endometrium. However, close follow up is required because of risks of conservative treatment.
authors.affiliation: Mehri Jafari Shobeiri, Associate Professor, Department of Gynecologic Oncology, Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Jafari Shobeiri
authors.affiliation: Parvin Mostafa Gharabaghi, Associate Professor, Department of Gynecologic Oncology, Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Mostafa Gharabaghi
authors.affiliation: Heidarali Esmaeili, Associate Professor, Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Heidarali
authors.initials: H
authors.lastname: Esmaeili
authors.affiliation: Elaheh Ouladsahebmadarek, Associate Professor, Department of Gynecologic Oncology, Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Ouladsahebmadarek
authors.affiliation: Mahzad Mehrzad-Sadagiani, Associate Professor, Department of Infertility and Reproductive, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahzad
authors.initials: M
authors.lastname: Mehrzad-Sadagiani
keywords: Endometrial carcinoma; Fertility preservation; Progestins; conservative treatment