title: Investigation of the oral infections and manifestations seen in patients with advanced cancer.
abstract: OBJECTIVE
  A prospective, observational study was undertaken to investigate the epidemiology of oral infection among the patients with advanced malignancies, and to investigate the effects of therapy strategies and risk factors on the incidence of oral infection.
  
  
  METHODS
  The patients with advanced malignancies were enrolled into the study. The incidence of oral infection with different malignant tumor groups or different treatment methods and the diagnoses of oral infection were confirmed. Demographic data on age, gender, bed rest time, nutritional status, smoking habit and the presence of oral prosthesis were also recorded.
  
  
  RESULTS
  Oral infection was prevalent in 46% (391/850) of all cancer patients, with the highest rate in oral and maxillofacial cancer group (67%), followed by Hematological malignancy group (58.6%) and other groups (ranging from 43.3% to 35.3%). Oral candidiasis, oral herpes simplex, and oral mucositis were the popular infectious diseases in the patients. Chemotherapy and radiotherapy, especially combined radio- and chemotherapy, resulted in more oral infections compared with palliative care and surgery. Poor nutritional status and oral prosthesis were identified as independent risk factors associated with oral infection.
  
  
  CONCLUSIONS
  Oral infection is prevalent among advanced cancer patients and associated with therapy methods and risk factors. More oral health care should be carried out for the patients with advanced malignant tumor.
authors.affiliation: LihuaXu, General Medicine Department, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Hualin Zhang, College of Stomatology, Ningxia Medical University, Yinchuan, China.
authors.forename: Hualin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Jinsong Liu, Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Xiaowei Chen, Gastroenterology and Hepatology Department, First Affiliated Hospital,Wenzhou Medical University, Wenzhou, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Chen
keywords: Advanced cancer; Oral health; Oral infection; Treatment strategy