title: Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes.
abstract: As an emerging research direction, nanomedicine has been increasingly utilized to treat inflammatory diseases. In this head-to-head comparison study, four established nanomedicine formulations of dexamethasone, including liposomes (L-Dex), core-cross-linked micelles (M-Dex), slow releasing polymeric prodrugs (P-Dex-slow), and fast releasing polymeric prodrugs (P-Dex-fast), were evaluated in an adjuvant-induced arthritis rat model with an equivalent dose treatment design. It was found that after a single i.v. injection, the formulations with the slower drug release kinetics (i.e., M-Dex and P-Dex-slow) maintained longer duration of therapeutic activity than those with relatively faster drug release kinetics, resulting in better joint protection. This finding will be instructional in the future development and optimization of nanomedicines for the clinical management of rheumatoid arthritis. The outcome of this study also illustrates the value of such head-to-head comparison studies in translational nanomedicine research.
authors.affiliation: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).
authors.forename: Lingdong
authors.initials: L
authors.lastname: Quan
authors.affiliation: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).
authors.forename: Yijia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Crielaard
authors.affiliation: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).
authors.forename: Anand
authors.initials: A
authors.lastname: Dusad
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).
authors.forename: Subodh M
authors.initials: SM
authors.lastname: Lele
authors.affiliation: Cristal Delivery B.V. Oxfordlaan 55, 6229 EV Maastricht, (The Netherlands).
authors.forename: Cristianne J F
authors.initials: CJF
authors.lastname: Rijcken
authors.affiliation: Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands).
authors.forename: Josbert M
authors.initials: JM
authors.lastname: Metselaar
authors.affiliation: Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic).
authors.forename: Hana
authors.initials: H
authors.lastname: Kostková
authors.affiliation: Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic).
authors.forename: Tomáš
authors.initials: T
authors.lastname: Etrych
authors.affiliation: Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic).
authors.forename: Karel
authors.initials: K
authors.lastname: Ulbrich
authors.affiliation: Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany).
authors.forename: Fabian
authors.initials: F
authors.lastname: Kiessling
authors.affiliation: Omaha VA Medical Center, 4101 Woolworth Avenue, Omaha, (USA).|Department Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE 68198, (USA).
authors.forename: Ted R
authors.initials: TR
authors.lastname: Mikuls
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).|Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands).
authors.forename: Gert
authors.initials: G
authors.lastname: Storm
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).|Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands).|Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany).
authors.forename: Twan
authors.initials: T
authors.lastname: Lammers
authors.affiliation: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D015519:Bone Density; D003907:Dexamethasone / Q000627:therapeutic use*; D008081:Liposomes; D008823:Micelles; D050997:Nanomedicine; D011108:Polymers; D051381:Rats; D055114:X-Ray Microtomography
chemical_list: D000893:Anti-Inflammatory Agents; D008081:Liposomes; D008823:Micelles; D011108:Polymers; D003907:Dexamethasone