title: The effects of acute administration of Chinese aphrodisiacs sold in Blantyre City on sperm characteristics and fertility profile in guinea pigs.
abstract: BACKGROUND
  Chinese aphrodisiacs have become popular remedy for sexual dysfunction and improvement of libido in men in Malawi. However, selling of these drugs seems not to be well regulated. Probably the aphrodisiacs that are currently on the market have unknown efficacy, potency and safety profiles. The aim of this study was to assess the efficacy of imported Chinese aphrodisiacs using guinea pigs as a model.
  
  
  METHODS
  Two types of drugs were purchased from vendors in Blantyre City. Tonic tea, which was purported to improve erectile function and libido, and sperm multiplier tablets which were claimed to increase the sperm count. The tonic tea was prepared by soaking one tea bag in 100ml boiling water. The tea was cooled and administered to eight male experimental animals in varying doses. Each animal was introduced into a separate cage with a female guinea pig. Sexual behaviour such as mounting, sniffing behind the female were observed and recorded. Each sperm multiplier tablet was dissolved in distilled water and administered to the experimental animals in the morning and evening for seven days. At the end of the treatment, the experimental and control animals were sacrificed, their semen collected and analysed sperm motility, concentration and morphology.
  
  
  RESULTS
  For the tonic tea, there were no statistical differences between the experimental and the control animals in terms of the number of mountings and sniffing behind the female. The sperm multiplier drug showed statistically significant differences between the experimental and the control animals in terms of the sperm motility (78.24 ± 1.35 vs. 86.54 ± 1.88, p< 0.05), and concentration (54.28 ± 1.24 vs. 67.59 ± 2.12, p<0.05).
  
  
  CONCLUSIONS
  The tonic tea did not show any efficacy in improving erection and libido. The sperm multiplier tablets, purported to increase sperm production, significantly increased the sperm motility, sperm concentration in the treated animals.
authors.affiliation: Department of Basic Medical Sciences, Division of Physiology, College of Medicine, University of Malawi.
authors.forename: F
authors.initials: F
authors.lastname: Lampiao
authors.affiliation: Department of Pharmacy, College of Medicine, University of Malawi.
authors.forename: E
authors.initials: E
authors.lastname: Matambo
authors.affiliation: Department of Pharmacy, College of Medicine, University of Malawi.
authors.forename: A
authors.initials: A
authors.lastname: Banda
mesh_terms: D000818:Animals; D001046:Aphrodisiacs / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006168:Guinea Pigs; D007989:Libido / Q000187:drug effects; D008295:Malawi; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D012661:Semen / Q000187:drug effects; D012725:Sexual Behavior; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D001046:Aphrodisiacs