title: Circulating autoantibodies to LGALS3BP: a novel biomarker for cancer.
abstract: OBJECTIVE
  Circulating autoantibodies have been extensively investigated as possible markers for early diagnosis of cancer. The present study was carried out to investigate whether anti-LGALS3BP IgG autoantibodies could be classified as a biomarker for malignant tumors.
  
  
  METHODS
  An in-house developed enzyme-linked immunosorbent assay was used to detect autoantibodies to LGALS3BP in sera from 71 patients with various types of cancers and 54 healthy subjects matched by age and gender.
  
  
  RESULTS
  Patients with cancer have significant higher circulating levels of anti-LGALS3BP antibodies as compared to control subjects (P < 0.001). The test has a sensitivity of 33% and a specificity of 98%.
  
  
  CONCLUSIONS
  Anti-LGALS3BP IgG autoantibodies are a promising biomarker for malignant tumors and could play a role in the development of a multimarker assay for the early detection of cancer.
authors.affiliation: Department of Experimental and Clinical Sciences, "G. D'Annunzio" University, 66100 Chieti, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Grassadonia
authors.affiliation: Department of Experimental and Clinical Sciences, "G. D'Annunzio" University, 66100 Chieti, Italy ; MediaPharma s.r.l., Via dei Vestini 31, 66100 Chieti, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Tinari
authors.affiliation: Department of Experimental and Clinical Sciences, "G. D'Annunzio" University, 66100 Chieti, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Natoli
authors.affiliation: Eventus Diagnostics, Inc., Jehuda Hills, 90880 Ora, Israel.
authors.forename: Galit
authors.initials: G
authors.lastname: Yahalom
authors.affiliation: Department of Experimental and Clinical Sciences, "G. D'Annunzio" University, 66100 Chieti, Italy ; MediaPharma s.r.l., Via dei Vestini 31, 66100 Chieti, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Iacobelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000276:immunology; D002352:Carrier Proteins / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D012680:Sensitivity and Specificity; D016326:Extracellular Matrix Proteins
chemical_list: D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D006023:Glycoproteins; D007074:Immunoglobulin G; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins