title: Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents.
abstract: It has been known for approximately 30 years that large doses of the semi-essential basic amino acid L-arginine induce severe pancreatic inflammation in rats. Recently, it has been demonstrated that L-arginine can also induce pancreatitis in mice. Moreover, other basic amino acids like L-ornithine and L-lysine can cause exocrine pancreatic damage without affecting the endocrine parenchyma and the ducts in rats. The utilization of these noninvasive severe basic amino acid-induced pancreatitis models is becoming increasingly popular and appreciated as these models nicely reproduce most laboratory and morphological features of human pancreatitis. Consequently, the investigation of basic amino acid-induced pancreatitis may offer us a better understanding of the pathogenesis and possible treatment options of the human disease.
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Kui
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Balla
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Eszter T
authors.initials: ET
authors.lastname: Végh
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Petra
authors.initials: P
authors.lastname: Pallagi
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
authors.forename: Viktória
authors.initials: V
authors.lastname: Venglovecz
authors.affiliation: Department of Pathology, University of Szeged, Szeged, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Iványi
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Takács
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Hegyi
authors.affiliation: First Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Rakonczay
mesh_terms: D024361:Amino Acids, Basic / Q000009:adverse effects*; D000818:Animals; D001120:Arginine / Q000009:adverse effects / Q000378:metabolism*; D004195:Disease Models, Animal; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D006652:Histological Techniques; D008239:Lysine / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009952:Ornithine / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010179:Pancreas / Q000502:physiology*; D010195:Pancreatitis / Q000139:chemically induced* / Q000503:physiopathology*; D051381:Rats; D012038:Regeneration / Q000502:physiology*
chemical_list: D024361:Amino Acids, Basic; D001120:Arginine; D009952:Ornithine; D008239:Lysine