title: Helicobacter pylori and interleukin-8 in gastric cancer.
abstract: Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Ko Eun
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Pham Ngoc
authors.initials: PN
authors.lastname: Khoi
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Jung Sun
authors.initials: JS
authors.lastname: Park
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Joo
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Kyung Keun
authors.initials: KK
authors.lastname: Kim
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Seok Yong
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
authors.forename: Young Do
authors.initials: YD
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism; D015195:Drug Design; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D016209:Interleukin-8 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D011379:Prognosis; D053700:Receptors, Interleukin-8 / Q000037:antagonists & inhibitors / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; C508606:CXCL8 protein, human; D016209:Interleukin-8; D053700:Receptors, Interleukin-8
keywords: Gastric cancer; Helicobacter pylori; Interleukin-8; Signals; Therapeutics