title: Endoscopic lung volume reduction. An American perspective.
abstract: There are limited therapies for severe emphysema. Bronchoscopic treatments of emphysema were introduced to achieve the beneficial physiological changes seen in surgical lung volume reduction; however, at the present time these treatments are mostly aimed at improving quality of life and functional status in patients with emphysema. At this time, none of these minimally invasive approaches have been approved in the United States for treatment of emphysema; however, several novel interventions have demonstrated potential in early-phase clinical trials. We performed a systematic evaluation of the relevant medical literature and present herein an evidence-based review of bronchoscopic treatments for emphysema, with a focus on the current status of this technology in the United States as compared with Europe.
authors.affiliation: 1 Interventional Pulmonology, Pulmonary Disease, and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Lee
authors.forename: Samira
authors.initials: S
authors.lastname: Shojaee
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Sterman
mesh_terms: D001999:Bronchoscopy / Q000379:methods*; D005060:Europe; D006801:Humans; D011013:Pneumonectomy / Q000379:methods*; D011656:Pulmonary Emphysema / Q000601:surgery*; D011788:Quality of Life; D016896:Treatment Outcome; D014481:United States