title: Lymphoepithelial carcinoma--review of the treatment modalities and report of a rare case in the sublingual gland.
abstract: Controversies exist in the current literature regarding the treatment of lymphoepithelial carcinoma (LEC). The presented study summaries the literature controversies in the treatment of LEC and present a case of a rare LEC diagnosed in the sublingual gland of an otherwise healthy 21-year-old Arab woman. The patient was admitted for swelling in the sublingual area. A biopsy indicated a diagnosis of LEC of the sublingual gland. Treatment included a wide resection with safe margins, marginal mandibulectomy, functional neck dissection, and a radial forearm free flap for reconstruction. The patient received concomitant radiotherapy and has remained disease free since her last follow-up. The recommended primary treatment, based on the literature review, is primary surgical excision with neck dissection and optional adjuvant radiotherapy to the gland area. Chemotherapy was not found to be beneficial according to the literature.
authors.affiliation: Clinical Instructor, Technion Faculty of Medicine, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel. Electronic address: yleiser@gmail.com.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Leiser
authors.affiliation: Clinical Associate Professor, Technion Faculty of Medicine, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel.
authors.forename: Micha
authors.initials: M
authors.lastname: Peled
authors.affiliation: Oral and Maxillofacial Trainee, Rambam Medical Center, Haifa, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Wolff
authors.affiliation: Clinical Assistant Professor, Technion Faculty of Medicine, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel.
authors.forename: Imad Abu
authors.initials: IA
authors.lastname: El-Naaj
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000601:surgery* / Q000821:virology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D058752:Free Tissue Flaps / Q000637:transplantation; D005927:Glossectomy / Q000379:methods; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008334:Mandible / Q000601:surgery; D063175:Mandibular Reconstruction / Q000295:instrumentation; D009060:Mouth Floor / Q000601:surgery; D037981:Neck Dissection; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures / Q000379:methods; D013362:Sublingual Gland Neoplasms / Q000601:surgery* / Q000821:virology; D055815:Young Adult