title: Poly(acrylic acid)-poly(ethylene glycol) nanoparticles designed for ophthalmic drug delivery.
abstract: Poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG), four-arm, amine-terminated particles with nanometer size and spherical shape were obtained by the polymers cross-linking, via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride, in a w/o emulsion. The morphology and surface charge of the final particles are strongly dependent on the molar ratio of PAA-PEG and the PAA concentration. The physicochemical characteristics correlated with the drug-loading capacity, in vitro and ex vivo release kinetics of pilocarpine hydrochloride and biocompatibility results indicate that these nanoparticles exhibit the prerequisite behavior for use as carriers of ophthalmic drugs.
authors.affiliation: Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University, Iasi, 700050, Romania.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Vasi
authors.forename: Marcel Ionel
authors.initials: MI
authors.lastname: Popa
authors.forename: Edi Constantin
authors.initials: EC
authors.lastname: Tanase
authors.forename: Maria
authors.initials: M
authors.lastname: Butnaru
authors.forename: Liliana
authors.initials: L
authors.lastname: Verestiuc
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000465:Algorithms; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003315:Cornea / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004058:Diffusion; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004563:Electrochemistry; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D009883:Ophthalmic Solutions / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011817:Rabbits; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D009883:Ophthalmic Solutions; D011092:Polyethylene Glycols; C006903:carbopol 940
keywords: biocompatibility; controlled release/delivery; formulation; nanoparticles; ophthalmic carriers; poly (acrylic acid); poly (ethylene glycol) four arms amine terminated; polymeric biomaterials; w/o emulsion