title: Common stress and serum cortisol and IL-12 levels in missed abortion.
abstract: To investigate stress levels, serum cortisol levels, and changes in IL-12 concentration in patients with missed abortion. Patients with missed abortion (n = 48) were age and gestational age-matched with normal early pregnancy cases (n = 48). All subjects completed a stress evaluation survey questionnaire about common stressors. Venous blood samples were collected at 07.00 hours, and serum cortisol and IL-12 concentrations were measured by electrochemiluminescence immunoassay and ELISA methods, respectively. Missed abortion patients demonstrated a significantly higher number of common stressors and higher serum cortisol levels compared to controls (both p < 0.05). Dilation and curettage did not lead to significant differences in serum cortisol and IL-12 levels (p > 0.05). Stress and immunity alterations of the immune system may contribute to the aetiology of missed abortion.
authors.affiliation: Department of Obstetrics and Gynecology, Shenzhen the Seventh People's Hospital , Shenzhen, Guangdong , China.
authors.forename: C-F
authors.initials: CF
authors.lastname: Tian
authors.forename: M-H
authors.initials: MH
authors.lastname: Kang
mesh_terms: D000030:Abortion, Missed / Q000097:blood / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D018664:Interleukin-12 / Q000097:blood*; D011247:Pregnancy; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000150:complications*; D055815:Young Adult
chemical_list: D018664:Interleukin-12; D006854:Hydrocortisone