title: High drinking in the dark mice: a genetic model of drinking to intoxication.
abstract: Drinking to intoxication is a critical component of risky drinking behaviors in humans, such as binge drinking. Previous rodent models of alcohol consumption largely failed to demonstrate that animals were patterning drinking in such a way as to experience intoxication. Therefore, few rodent models of binge-like drinking and no specifically genetic models were available to study possible predisposing genes. The High Drinking in the Dark (HDID) selective breeding project was started to help fill this void, with HDID mice selected for reaching high blood alcohol levels in a limited access procedure. HDID mice now represent a genetic model of drinking to intoxication and can be used to help answer questions regarding predisposition toward this trait as well as potential correlated responses. They should also prove useful for the eventual development of better therapeutic strategies.
authors.affiliation: Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Portland Alcohol Research Center, VA Medical Center, Portland, OR 97239, USA. Electronic address: barkleya@ohsu.edu.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Barkley-Levenson
authors.affiliation: Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Portland Alcohol Research Center, VA Medical Center, Portland, OR 97239, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Crabbe
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics; D000435:Alcoholic Intoxication / Q000235:genetics*; D000818:Animals; D002940:Circadian Rhythm; D003624:Darkness; D004195:Disease Models, Animal; D000431:Ethanol / Q000097:blood; D051379:Mice
chemical_list: D000431:Ethanol
keywords: Binge; Drinking in the dark; Ethanol consumption; Genetics; Selective breeding