title: Prebiotic phosphate ester syntheses in a deep eutectic solvent.
abstract: We report a route to synthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (2:1 urea and choline chloride), utilizing various orthophosphate sources. Heating an organic alcohol in the solvent along with a soluble phosphorus source yields phosphorus esters of choline as well as that of the added organic in yields between 15 to 99 %. In addition, phosphite analogs of biological phosphates and peptides were also formed by the simple mixing of reagents and heating at 60-70 °C in the deep eutectic solvent. The presented dehydration reactions are relevant to prebiotic and green chemistry in alternative solvents.
authors.affiliation: School of Geosciences, University of South Florida, NES 107, 4202 East Fowler Ave, Tampa, FL, 33620, USA, ambermaheen@yahoo.com.
authors.forename: Maheen
authors.initials: M
authors.lastname: Gull
authors.forename: Manshui
authors.initials: M
authors.lastname: Zhou
authors.forename: Facundo M
authors.initials: FM
authors.lastname: Fernández
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Pasek
mesh_terms: D002794:Choline / Q000737:chemistry; D004952:Esters; D010755:Organophosphates / Q000138:chemical synthesis*; D056692:Prebiotics; D012997:Solvents / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
chemical_list: D004952:Esters; D010755:Organophosphates; D056692:Prebiotics; D012997:Solvents; D014508:Urea; D002794:Choline