title: [Update on gastroesophageal reflux disease].
abstract: Gastroesophageal reflux disease is a highly frequent disorder classically characterized by the presence of heartburn and/or acid regurgitation that improves with drug therapy that reduces acid content in the stomach. However, especially in patients with non-erosive disease, response to proton pump inhibitors is unsatisfactory in approximately 1 out of 3 patients, and consequently, in these patients, it is important to establish a definitive diagnosis and an alternative therapeutic strategy. In the last few years, advances have been made in knowledge of the physiopathology of reflux, such as identification of the role of the acid pocket in producing reflux, technological advances that allow differentiation among acid reflux, non-acid reflux and slightly acid reflux, and advances in the treatment of reflux with drugs that attempt to act on the barrier function of the esophagogastric junction.
authors.affiliation: CIBERehd, Unidad de Motilidad y Trastornos Funcionales Digestivos, Servicio de Aparato Digestivo, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: jserrap.germanstrias@gencat.cat.
authors.forename: Jordi
authors.initials: J
authors.lastname: Serra Pueyo
mesh_terms: D000464:Alginates / Q000627:therapeutic use; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use; D015897:Comorbidity; D004338:Drug Combinations; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D004943:Esophagogastric Junction / Q000503:physiopathology / Q000601:surgery; D018662:Fundoplication; D005746:Gastric Emptying; D005764:Gastroesophageal Reflux / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D005773:Gastroscopy; D006551:Hernia, Hiatal / Q000150:complications; D006801:Humans; D008365:Manometry; D050177:Overweight / Q000453:epidemiology; D019518:Postprandial Period; D011187:Posture; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012824:Silicic Acid / Q000627:therapeutic use; D017693:Sodium Bicarbonate / Q000627:therapeutic use
chemical_list: D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D054328:Proton Pump Inhibitors; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate
keywords: Acid pocket; Alginate; Alginato; Bolsillo ácido; Gastroesophageal reflux; Impedance; Impedancia; Reflujo gastroesofágico