title: [Neurocognitive fuctioning in pure mania and mixed mania].
abstract: Neurocognitive dysfunction is increasingly recognized as a prominent feature of bipolar disorder. Cognitive function seems to be impaired across different states of bipolar illness. Nervertheless, research that studies neuropsychological functioning in acute phases is scarce. Acutely ill patients have shown dysfunctions in several cognitive areas. We reviewed the literature on neuropsychological studies of acute phases to highlight neurocognitive deficits in mixed and pure mania. The results show dysfunctions in sustained attention that are significantly more important in mixed mania rather than in pure mania. Impulsive pattern of responding seems to characterize pure manic state. We also found impairments in processing speed, verbal and spatial learning/memory and executive functions, including cognitive flexibility, inhibitory control, conceptual reasoning, planning and problem solving. Disturbance in executive functioning seems to be more important in pure mania rather than mixed mania.
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France. Electronic address: nadia.correard@ap-hm.fr.
authors.forename: N
authors.initials: N
authors.lastname: Corréarda
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France.
authors.forename: R
authors.initials: R
authors.lastname: Belzeaux
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France.
authors.forename: M
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France.
authors.forename: E
authors.initials: E
authors.lastname: Fakra
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte- Marguerite, 13274 Marseille cedex 09, France.
authors.forename: J-A
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: Pôle de psychiatrie centre, Hôpital de La Conception, Boulevard Baille, 13006 Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Dassa
authors.affiliation: Pôle de psychiatrie centre, Hôpital de La Conception, Boulevard Baille, 13006 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Dubois
authors.affiliation: Clinique de psychiatrie et de psychologie médicale, CHU Pasteur, 06002 Nice cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Pringuey
authors.affiliation: Pôle de psychiatrie des adultes, CHU Robert- Debré, Avenue du Général- Koenig, 51092 Reims cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Kaladjian
mesh_terms: D000339:Affect / Q000502:physiology; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D015897:Comorbidity; D003937:Diagnosis, Differential; D058068:Endophenotypes; D056344:Executive Function / Q000502:physiology; D006801:Humans; D011939:Mental Recall / Q000502:physiology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D011597:Psychomotor Performance / Q000502:physiology; D012016:Reference Values; D015203:Reproducibility of Results
keywords: Bipolar disorders; Mania; Manie; Mixed states; Neurocognition; Troubles bipolaires; États mixtes