title: Acute upper gastrointestinal bleeding secondary to Kaposi sarcoma as initial presentation of HIV infection.
abstract: Despite our decades of experience with Kaposi Sarcoma its true nature remains elusive. This angioproliferative disease of the vascular endothelium has a propensity to involve visceral organs in the immunocompromised population. There are four variants of the disease and each has its own pathogenesis and evolution. While the common sources of upper gastrointestinal bleeding are familiar to surgeons and critical care physicians, here we present the exceedingly rare report of upper gastrointestinal bleeding attributable to this malady, explore its successful management, and review the various forms of Kaposi Sarcoma including the strategies in regard to their management.
authors.affiliation: Department of Surgery, Division of Trauma, Critical Care, and Burn, The Ohio State University College of Medicine, Columbus, OH, USA; Email:stanislaw.stawicki@osumc.edu.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Mansfield
authors.forename: Stanislaw P A
authors.initials: SP
authors.lastname: Stawicki
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Forbes
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Papadimos
authors.forename: David E
authors.initials: DE
authors.lastname: Lindsey
mesh_terms: D000972:Antineoplastic Agents, Phytogenic; D023241:Antiretroviral Therapy, Highly Active; D014408:Biomarkers, Tumor / Q000032:analysis; D018791:CD4 Lymphocyte Count; D016145:Endoscopy, Digestive System; D017707:Erythrocyte Transfusion; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000628:therapy; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D064847:Multimodal Imaging; D017239:Paclitaxel / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000821:virology; D012514:Sarcoma, Kaposi / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D016756:Immunoglobulins, Intravenous; D017239:Paclitaxel