title: Hydrophobic sol-gel channel patterning strategies for paper-based microfluidics.
abstract: Hydrophobic sol-gel derived methylsilsesquioxane (MSQ) was compared to wax and alkylketene dimer (AKD) as barrier materials defining channels in paper-based microfluidic devices. While all three of the barrier types performed well with water, only the MSQ barriers were not breached by aggressive cell lysing solutions and surfactant solutions (SDS, CTAB, Triton X-100). The MSQ barriers also withstood glycerol, toluene and DMSO whereas all three barrier types were breached by alcohols. MSQ based devices could be prepared either by direct inkjet printing of the barriers or by base etching of MSQ impregnated paper. The functionality of MSQ based devices was demonstrated by formatting a colormetric sensor for Escherichia coli.
authors.affiliation: Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Wang
authors.forename: Maria Rowena N
authors.initials: MR
authors.lastname: Monton
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Carlos D M
authors.initials: CD
authors.lastname: Filipe
authors.forename: Robert
authors.initials: R
authors.lastname: Pelton
authors.forename: John D
authors.initials: JD
authors.lastname: Brennan
mesh_terms: D004926:Escherichia coli / Q000166:cytology; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D017646:Organosilicon Compounds / Q000737:chemistry; D010209:Paper; D012833:Siloxanes / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry
chemical_list: D017646:Organosilicon Compounds; D012833:Siloxanes; D012972:Sodium Hydroxide