title: Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.
abstract: We describe a case of a patient with a functional kidney transplant who was admitted to our department with clinically evident central vein stenosis (CVS) 7 years after the removal of a central venous catheter (CVC) from the right internal jugular vein. The catheter was used as a hemodialysis access for a 2-month period. In the interval before his last admission, the patient suffered two episodes of deep vein thrombosis. Investigation revealed heterozygosity for factor V Leiden, the most common inherited thrombophilia encountered in 5% of Caucasians, and anticoagulation treatment was started. Magnetic resonance angiography showed stenosis just after the convergence of the right subclavian vein with the internal jugular vein to the innominate vein. Transluminal angioplasty restored venous patency and right upper arm edema resolved. Coexistence of CVS, accompanied by hemodynamic changes and endothelial dysfunction, with thrombophilia fulfill all the elements of the Virchow's triad. Therefore, the patient was at great risk for central vein thrombosis, from which he was possibly protected by the early administration of anticoagulant treatment. This case indicates that CVS can be asymptomatic for several years after CVC removal and also raises the question if thrombophilia workup and investigation for CVS may be beneficial in every patient with CVC placement in order to avoid any harmful outcomes.
authors.affiliation: Nephrology Department, Medical School, University of Thessaly, Larissa, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Eleftheriadis
authors.forename: Vassilios
authors.initials: V
authors.lastname: Liakopoulos
authors.forename: Georgia
authors.initials: G
authors.lastname: Antoniadi
authors.forename: Georgios
authors.initials: G
authors.lastname: Pissas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Leivaditis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stefanidis
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects*; D062905:Central Venous Catheters / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D019851:Thrombophilia / Q000150:complications*; D014652:Vascular Diseases / Q000209:etiology
keywords: Central venous catheter; central vein stenosis; hemodialysis; thrombophilia