title: An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans.
abstract: Despite accumulating evidence for a reconsolidation process in animals, support in humans, especially for episodic memory, is limited. Using a within-subjects manipulation, we found that a single application of electroconvulsive therapy following memory reactivation in patients with unipolar depression disrupted reactivated, but not non-reactivated, memories for an emotional episode in a time-dependent manner. Our results provide evidence for reconsolidation of emotional episodic memories in humans.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Marijn C W
authors.initials: MC
authors.lastname: Kroes
authors.affiliation: 1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. [3] Department of Psychiatry and Psychotherapy, University Hospital Essen, Essen, Germany.
authors.forename: Indira
authors.initials: I
authors.lastname: Tendolkar
authors.affiliation: 1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Guido A
authors.initials: GA
authors.lastname: van Wingen
authors.affiliation: Department of Psychiatry, Rijnstate Hospital, Arnhem, The Netherlands.
authors.forename: Jeroen A
authors.initials: JA
authors.lastname: van Waarde
authors.affiliation: Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, UPM, Madrid, Spain.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Strange
authors.affiliation: 1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Guillén
authors.initials: G
authors.lastname: Fernández
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002755:Choice Behavior / Q000502:physiology; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008433:Mathematics; D008569:Memory Disorders / Q000209:etiology*; D061212:Memory, Episodic; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors