title: Advances in adult asthma diagnosis and treatment in 2013.
abstract: In 2013, several themes emerged: (1) a dedicated search for new therapies using new mechanisms; (2) the importance of the plasticity of the immune system (eg, that molecules that mediate inflammation in one setting can promote its resolution and return to homeostasis in other circumstances); (3) the complex role of viruses in asthma exacerbations; (4) the similarities and differences among asthma, asthma in smokers, and chronic obstructive pulmonary disease; and (5) the importance of understanding asthma phenotypes and their stability over time. Once new therapeutics pass the initial clinical trials, patient-oriented and real-world research will be needed.
authors.affiliation: Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pa. Electronic address: apter@mail.med.upenn.edu.
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Apter
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000730:Androstadienes / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D057285:Precision Medicine; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000235:genetics
chemical_list: D000305:Adrenal Cortex Hormones; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents
keywords: ACQ; Alveolar fraction of exhaled nitric oxide; Asthma; Asthma Control Questionnaire; C(alv)NO; COPD; CRTH2; Chemoattractant receptor homologous molecule expressed on T(H)2 cells; Chronic obstructive pulmonary disease; EBC; Exhaled breath condensate; Feno; Fraction of exhaled nitric oxide; ICS; Inhaled corticosteroid; LABA; Long-acting β-agonist; OA; Occupational asthma; PGD(2); PROM; Patient-reported outcome measure; Prostaglandin D(2); SLIT; Sublingual immunotherapy; TLR; Toll-like receptor; WEA; WRA; Work-exacerbated asthma; Work-related asthma; adults; asthma management; inhaled corticosteroids