title: Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB.
abstract: This study explores the therapeutic effects of Xiangshao granules in a mouse depression model and examines the potential molecular mechanisms involved. After 21 consecutive days of chronic stress challenge, all mice were divided into three groups: control group, depression group, and Xiangshao granule treatment group. On the 22nd day, rats in the Xiangshao granule treatment group received Xiangshao granules via gastrogavage for 3 consecutive weeks. Depression group mice showed a significant reduction of crossings (P < 0.01) but not rearings (P < 0.05). Serum CRH, CORT, and ACTH levels were significantly increased in depression mice compared with control (P < 0.05) and the expression levels of hippocampal BDNF and TrkB were reduced in the model group (P < 0.05). However, Xiangshao granule treatment remarkably rescued the decrease in the body weight (P < 0.05), increased crossings in the open field test (P < 0.05), upregulated the expression of hippocampal BDNF and TrkB expression, and reduced the serum CRH, CORT, and ACTH concentrations compared with the depression group (P < 0.05). Collectively, these results demonstrated that Xiangshao granule could effectively induce antidepressive effects in the depression mouse model by ameliorating the expression of hippocampal BDNF and TrkB.
authors.affiliation: Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Wu
authors.affiliation: Monash University, Department of Biochemistry and Molecular Biology, Clayton, Victoria 3800, Australia ; Visiting Professor, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Edouard Collins
authors.initials: EC
authors.lastname: Nice