title: Antioxidant and anti-inflammatory effects of curcumin against hepatorenal oxidative injury in an experimental sepsis model in rats.
abstract: BACKGROUND
  To investigate the effects of curcumin, an antioxidant and anti-inflammatory agent, on free oxygen radicals and lipid peroxidation in an experimental sepsis model, as well as to determine the role of curcumin in preventing hepatorenal tissue damage caused by sepsis.
  
  
  METHODS
  The rats were randomly divided into three groups (n=8) as follows: control group (group 1); sepsis group (group 2); and sepsis + curcumin group (group 3). Sepsis was created using the cecal ligation and perforation (CLP) method. Curcumin was administered intraperitoneally (200 mg/kg) in two equal doses just after the perforation and at twelve hours post-perforation.
  
  
  RESULTS
  Serum TNF-a and IL-1ß, and tissue MDA and MPO values were higher, whereas tissue GSH and Na+/K+-ATPase values were lower, in group 2 as compared to group 1. These values in group 3 were the inverse of those in group 2. As compared to group 1, histopathological evaluation of group 2 showed damaged hepatocytes, glomeruli, and tubules, whereas the damage was significantly reduced in group 3 as compared to group 2.
  
  
  CONCLUSIONS
  The strong antioxidant and anti-inflammatory effects of curcumin against potential hepatorenal damage were shown using an experimental sepsis model in rats.
authors.affiliation: Department of General Surgery, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
authors.forename: Gülay
authors.initials: G
authors.lastname: Yılmaz Savcun
authors.affiliation: Department of General Surgery, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Ozkan
authors.affiliation: Department of General Surgery, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Dulundu
authors.affiliation: Department of General Surgery, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Topaloğlu
authors.affiliation: Department of Pharmacology, Marmara University Faculty of Pharmacy, İstanbul, Turkey.
authors.forename: Ahmet Ozer
authors.initials: AO
authors.lastname: Sehirli
authors.affiliation: Department of Histology and Embryology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Olgu Enis
authors.initials: OE
authors.lastname: Tok
authors.affiliation: Department of Histology and Embryology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Feriha
authors.initials: F
authors.lastname: Ercan
authors.affiliation: Department of Pharmacology, Marmara University Faculty of Pharmacy, İstanbul, Turkey.
authors.forename: Göksel
authors.initials: G
authors.lastname: Sener
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002432:Cecum / Q000473:pathology; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005609:Free Radicals / Q000378:metabolism; D006530:Hepatorenal Syndrome / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D008026:Ligation; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000097:blood / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005609:Free Radicals; D014409:Tumor Necrosis Factor-alpha; D003474:Curcumin