title: The obesity of patients with Laron Syndrome is not associated with excessive nutritional intake.
abstract: CONCLUSIONS
  
  
  
  OBJECTIVE
  To study the metabolic parameters which may affect the excessive weight of treated and untreated patients with Laron Syndrome.
  
  
  METHODS
  Body composition, daily caloric intake and resting energy expenditure (REE), when possible, were measured for each patient. Caloric intake was calculated based on 7-day food records, REE was measured by indirect calorimetry and body composition was determined by dual energy X-ray absorptiometry (DEXA).
  
  
  METHODS
  Nine untreated adult subjects with Laron Syndrome (6 female subjects, 3 male subjects) aged 28-53 years and 4 girls with Laron Syndrome treated by insulin-like growth factor-I (IGF-I) 120-150 μg/kg/d were included in the study.
  
  
  RESULTS
  Patients with Laron Syndrome have an abnormally high body fat (BF) mass (54 ± 10% of body weight) and a relatively low lean body mass (LBM) compared to a healthy normal population. Energy intake varied but in most of the patients was not significantly higher than the measured REE. The REE corrected for LBM was higher than expected, based on our norms for healthy adults. The mean distribution of energy sources in the food was 47% carbohydrates, 17% protein and 36% fat.
  
  
  CONCLUSIONS
  The severe obesity of patients with Laron Syndrome is not due to hyperphagia or hypometabolism.
authors.affiliation: Unit of Clinical Nutrition, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shira
authors.initials: S
authors.lastname: Ginsberg
authors.affiliation: Unit of Clinical Nutrition, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:laronz@clalit.org.il.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Laron
authors.affiliation: Unit of Clinical Nutrition, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Mira Arbiv
authors.initials: MA
authors.lastname: Bed
authors.affiliation: Unit of Clinical Nutrition, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nachum
authors.initials: N
authors.lastname: Vaisman