title: Role of miRNAs and epigenetics in neural stem cell fate determination.
abstract: The regulation of gene expression that determines stem cell fate determination is tightly controlled by both epigenetic and posttranscriptional mechanisms. Indeed, small non-coding RNAs such as microRNAs (miRNAs) are able to regulate neural stem cell fate by targeting chromatin-remodeling pathways. Here, we aim to summarize the latest findings regarding the feedback network of epigenetics and miRNAs during embryonic and adult neurogenesis.
authors.affiliation: Yale Cardiovascular Research Center; Section of Cardiovascular Medicine; Yale University School of Medicine; New Haven, CT USA.
authors.forename: Miguel Alejandro
authors.initials: MA
authors.lastname: Lopez-Ramirez
authors.affiliation: Yale Cardiovascular Research Center; Section of Cardiovascular Medicine; Yale University School of Medicine; New Haven, CT USA.
authors.forename: Stefania
authors.initials: S
authors.lastname: Nicoli
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D044127:Epigenesis, Genetic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs
keywords: cell fate determination; epigenetics machinery; microRNAs; neural stem cells; neurogenesis