title: Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-Löwenstein tumor): a case report and review of the literature.
abstract: BACKGROUND
  Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential.
  
  
  METHODS
  We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke-Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.
  
  
  CONCLUSIONS
  The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke-Löwenstein tumor) and discuss the literature on its diagnosis and management.
authors.affiliation: Department of Urology, University Hospital Center Hassan II, 30000 Fez, Morocco. drahsaini@gmail.com.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Ahsaini
authors.forename: Yasser
authors.initials: Y
authors.lastname: Tahiri
authors.forename: Mohammed Fadl
authors.initials: MF
authors.lastname: Tazi
authors.forename: Jallaledine
authors.initials: J
authors.lastname: Elammari
authors.forename: Soufiane
authors.initials: S
authors.lastname: Mellas
authors.forename: Abdelhak
authors.initials: A
authors.lastname: Khallouk
authors.forename: Mohammed Jamal
authors.initials: MJ
authors.lastname: El Fassi
authors.forename: My Hassan
authors.initials: MH
authors.lastname: Farih
authors.forename: Hind
authors.initials: H
authors.lastname: Elfatmi
authors.forename: Afaf
authors.initials: A
authors.lastname: Amarti
authors.forename: Roos E
authors.initials: RE
authors.lastname: Stuurman-Wieringa