title: Efficacy of plasma-rich growth factor in the healing of postextraction sockets in patients affected by insulin-dependent diabetes mellitus.
abstract: OBJECTIVE
  To evaluate the efficacy of plasma-rich growth factor (PRGF) in improving socket healing after tooth extraction in diabetic patients.
  
  
  METHODS
  This was a split-mouth study in which each patient also served as the control: the study socket was treated with PRGF, whereas the control socket underwent natural healing. The outcome variables were the Healing Index, residual socket volume, visual analog scale score, postsurgical complications, and outcome of a patient questionnaire. The investigation considered the impact of hyperglycemia, glycated hemoglobin, End Organ Disease Score, and smoking habits. Follow-up included 4 postextraction checkups over a 21-day period. Pairs of correlated continuous variables were analyzed with the Wilcoxon test, independent continuous variables with the Mann-Whitney test, and categorical variables with the χ(2) test or Fisher test.
  
  
  RESULTS
  From January 2012 to December 2012, 34 patients affected by insulin-dependent diabetes mellitus underwent contemporary bilateral extractions of homologous teeth. The treatment-versus-control postoperative comparison showed that PRGF resulted in significantly smaller residual socket volumes and better Healing Indices from days 3 to 14. The patients' questionnaire outcomes were unanimously in favor of PRGF treatment. The small sample of patients with glycemia values of at least 240 mg/dL showed worse Healing Index and minor socket decreases.
  
  
  CONCLUSIONS
  PRGF application after extraction improved the healing process in diabetic patients by accelerating socket closure (epithelialization) and tissue maturation, proving the association between PRGF use and improved wound healing in diabetic patients.
authors.affiliation: Doctor, SIOM Oral Surgery and Implantology Center, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Mozzati
authors.affiliation: Doctor, SIOM Oral Surgery and Implantology Center, Turin, Italy. Electronic address: giorgiagallesio@libero.it.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Gallesio
authors.affiliation: Trainee, Surgery Unit, Dentistry Section, Department of Surgical Sciences, University of Turin, Turin, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: di Romana
authors.affiliation: Full Professor, Department of Surgical Sciences, University of Turin, Turin, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bergamasco
authors.affiliation: Consultant, Oral Surgery Unit, Dentistry Section, Department of Surgical Sciences, University of Turin, Turin, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Pol
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D017742:Dental Care for Chronically Ill / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D023381:Endpoint Determination; D004847:Epithelial Cells / Q000187:drug effects; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006133:Growth Substances