title: An inverse finite element method for determining the tissue compressibility of human left ventricular wall during the cardiac cycle.
abstract: The determination of the myocardium's tissue properties is important in constructing functional finite element (FE) models of the human heart. To obtain accurate properties especially for functional modeling of a heart, tissue properties have to be determined in vivo. At present, there are only few in vivo methods that can be applied to characterize the internal myocardium tissue mechanics. This work introduced and evaluated an FE inverse method to determine the myocardial tissue compressibility. Specifically, it combined an inverse FE method with the experimentally-measured left ventricular (LV) internal cavity pressure and volume versus time curves. Results indicated that the FE inverse method showed good correlation between LV repolarization and the variations in the myocardium tissue bulk modulus K (K = 1/compressibility), as well as provided an ability to describe in vivo human myocardium material behavior. The myocardium bulk modulus can be effectively used as a diagnostic tool of the heart ejection fraction. The model developed is proved to be robust and efficient. It offers a new perspective and means to the study of living-myocardium tissue properties, as it shows the variation of the bulk modulus throughout the cardiac cycle.
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia ; Center of Advanced Manufacturing & Material processing, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Abdallah I
authors.initials: AI
authors.lastname: Hassaballah
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia ; Center of Advanced Manufacturing & Material processing, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia ; Department of Mechanical Engineering, Faculty of Engineering, Assiut University, Assiut, Egypt.
authors.forename: Mohsen A
authors.initials: MA
authors.lastname: Hassan
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia ; Center of Advanced Manufacturing & Material processing, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Azizi N
authors.initials: AN
authors.lastname: Mardi
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia ; Center of Advanced Manufacturing & Material processing, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Mohd
authors.initials: M
authors.lastname: Hamdi
mesh_terms: D000465:Algorithms; D004548:Elasticity; D020342:Finite Element Analysis; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008962:Models, Theoretical; D009206:Myocardium / Q000378:metabolism