title: Cilia and coordination of signaling networks during heart development.
abstract: Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.
authors.affiliation: Department of Biology; University of Copenhagen; Copenhagen, Denmark; Wilhelm Johannsen Centre for Functional Genome Research; Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Koefoed
authors.affiliation: Department of Biology; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Iben Rønn
authors.initials: IR
authors.lastname: Veland
authors.affiliation: Department of Biology; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Lotte Bang
authors.initials: LB
authors.lastname: Pedersen
authors.affiliation: Wilhelm Johannsen Centre for Functional Genome Research; Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Lars Allan
authors.initials: LA
authors.lastname: Larsen
authors.affiliation: Department of Biology; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Søren Tvorup
authors.initials: ST
authors.lastname: Christensen
mesh_terms: D002923:Cilia; D006321:Heart / Q000196:embryology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D038081:Organogenesis / Q000502:physiology*; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D053773:Transforming Growth Factor beta1
keywords: cardiomyogenesis; congenital heart diseases; heart development; heterotaxy; nodal cilia; primary cilia; signaling networks; stem cells