title: Cardiac Hegemony of Senescence.
abstract: Cardiac senescence and age-related disease development have gained general attention and recognition in the past decades due to increased accessibility and quality of health care. The advancement in global civilization is complementary to concerns regarding population aging and development of chronic degenerative diseases. Cardiac degeneration has been rigorously studied. The molecular mechanisms of cardiac senescence are on multiple cellular levels and hold a multilayer complexity level, thereby hampering development of unambiguous treatment protocols. In particular, the synergistic exchange of the senescence phenotype through a senescence secretome between myocytes and stem cells appears complicated and is of great future therapeutic value. The current review article will highlight hallmarks of senescence, cardiac myocyte and stem cell senescence, and the mutual exchange of senescent secretome. Future cardiac cell therapy approaches require a comprehensive understanding of myocardial senescence to improve therapeutic efficiency as well as efficacy.
authors.affiliation: Department of Biology and Heart Institute, Integrated Regenerative Research Institute, San Diego State University, San Diego, California ; Department of Experimental Cardiology, University Medical Center, Utrecht, Netherlands.
authors.forename: Sailay
authors.initials: S
authors.lastname: Siddiqi
authors.affiliation: Department of Biology and Heart Institute, Integrated Regenerative Research Institute, San Diego State University, San Diego, California.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Sussman
keywords: Aging; Cardiac stem cells; Cardiomyocytes; Rejuvenation; Senescence; Senescence-associated secretory phenotype (SASP)