title: Cross-reactivity of Aspergillus galactomannan in an HIV-infected patient with histoplasmosis.
abstract: Non-invasive assays are increasingly being used in patients with suspected fungal infections. Limitations to these tests include limited sensitivity, specificity, and cross reactivity with other fungal pathogens. Herein we report a case of disseminated histoplasmosis producing a false positive serum and bronchoalveolar lavage (BAL) Aspergillus galactomannan assays. This test may have a role in the evaluation of patients with suspected histoplasmosis in settings where Histoplasma antigen testing is not widely available.
authors.affiliation: Division of Infectious Diseases, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294-0006, USA.
authors.forename: Zaw
authors.initials: Z
authors.lastname: Min
authors.affiliation: Division of Infectious Diseases, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294-0006, USA ; Birmingham Veterans Affairs Medical Center, 700 South 19th Street, Brimingham, AL 35233, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Baddley
authors.affiliation: Division of Infectious Diseases, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294-0006, USA.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Rodriguez
authors.affiliation: Department of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35249-7331, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Moser
authors.affiliation: Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, N555, Baltimore, MD 21201, USA.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Patel
keywords: Aspergillosis; Aspergillus galactomannan assay; Cross-reactivity; HIV/AIDS; Histoplasmosis