title: Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes.
abstract: OBJECTIVE
  To examine how fasting glucose and glucose tolerance are related to magnetic resonance imaging-assessed indicators of subclinical cerebrovascular disease and brain atrophy and their variation according to age, sex and education.
  
  
  METHODS
  Participants in the present study were 172 healthy, community-dwelling older adults. An oral glucose tolerance test was administered and magnetic resonance imaging performed. Fasting, 2-h, and 2-h area-under-the-curve glucose levels, their associations with subclinical cerebrovascular disease and brain atrophy, and their respective interactions with age, sex and education were examined.
  
  
  RESULTS
  A positive association between fasting glucose and subclinical cerebrovascular disease (but not brain atrophy) emerged; this association was more pronounced for participants with < 12 years of education; however, glucose tolerance was not related to subclinical cerebrovascular disease or brain atrophy.
  
  
  CONCLUSIONS
  Findings revealed a potential link between fasting glucose levels and the presence of subclinical cerebrovascular disease indicators - white matter hyperintensities and silent brain infarction - in older adults without diabetes and with an education level below high school. Additional research is needed to confirm these associations and to determine the need for interventions aimed at closely monitoring and preventing elevated glucose levels in this population to reduce the prevalence of subclinical cerebrovascular disease.
authors.affiliation: School of Nursing, University of Delaware, Newark, DE, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Sims
authors.forename: L I
authors.initials: LI
authors.lastname: Katzel
authors.forename: D M
authors.initials: DM
authors.lastname: Lefkowitz
authors.forename: E L
authors.initials: EL
authors.lastname: Siegel
authors.forename: W F
authors.initials: WF
authors.lastname: Rosenberger
authors.forename: Z
authors.initials: Z
authors.lastname: Manukyan
authors.forename: K E
authors.initials: KE
authors.lastname: Whitfield
authors.forename: S R
authors.initials: SR
authors.lastname: Waldstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000097:blood / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000473:pathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000473:pathology*; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D064368:Healthy Volunteers; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose