title: Histopathological Comparison among Biolimus, Zotarolimus and Everolimus-Eluting Stents in Porcine Coronary Restenosis Model.
abstract: OBJECTIVE
  The aim of this study was to examine the histolopathogical effects among the biolimus, zotarolimus, and everolimus eluting stent (EES) in the porcine coronary restenosis model.
  
  
  METHODS
  Pigs were randomized into three groups in which the coronary arteries (15 pigs, 10 coronaries in each group) had either a biolimus A9 eluting stent (BES, n=10), zotarolimus eluting stent (ZES, n=10) or an EES (n=10). Histopathologic analysis was performed at 28 days after stenting.
  
  
  RESULTS
  There were no significant differences in the injury score among the three groups. There was a significant difference in the internal elastic lamina, lumen area, neointima area, percent area stenosis, and the fibrin and inflammation score among the three groups (4.3±0.53 mm(2), 2.5±0.93 mm(2), 1.8±1.03 mm(2), 40.7±20.80%, 1.7±0.41, 1.4±0.72 in the BES group vs. 5.1±0.55 mm(2), 2.3±1.14 mm(2), 2.8±1.00 mm(2), 55.4±21.23%, 2.0±0.39, 1.6±0.76 in the ZES group vs. 4.4±0.53 mm(2), 1.7±1.22 mm(2), 2.8±1.23 mm(2), 64.0±26.00%, 1.8±0.76, 2.1±0.90 in the EES group, respectively). BES is more effective in inhibiting neointimal hyperplasia compared to ZES and EES (p<0.0001). According to the fibrin and inflammation score, BES and EES are more effective in decreasing the fibrin deposition compared to ZES (p<0.001). Moreover, BES and ZES are more effective in reducing the inflammatory reaction compared to EES (p<0.001).
  
  
  CONCLUSIONS
  The result demonstrates that BES shows better histopathological characteristics than ZES and EES at one month after stenting in the porcine coronary restenosis model.
authors.affiliation: Korea Cardiovascular Stent Institute, Jangseong, Korea. ; Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Kyung Seob
authors.initials: KS
authors.lastname: Lim
authors.affiliation: Korea Cardiovascular Stent Institute, Jangseong, Korea. ; Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea. ; Regeneromics Research Center, Chonnam National University, Gwangju, Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Korea Cardiovascular Stent Institute, Jangseong, Korea. ; Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors.forename: In Ho
authors.initials: IH
authors.lastname: Bae
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Dae Sung
authors.initials: DS
authors.lastname: Park
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jung Ha
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Dong Lyun
authors.initials: DL
authors.lastname: Cho
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Doo Sun
authors.initials: DS
authors.lastname: Sim
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
keywords: Coronary restenosis; Drug-eluting stents; Inflammation; Percutaneous coronary intervention