title: Association between Pituitary Langerhans Cell Histiocytosis and Papillary Thyroid Carcinoma.
abstract: Here we report a case of panhypopituitarism caused by pituitary Langerhans cell hystocitosis (LCH) in a 22-year-old woman affected by papillary thyroid carcinoma (PTC). Although several cases of the coexistence of PTC and LCH within thyroid tissue have been described in relative literature, in this case, the patient presented a unique suprasellar retrochiasmatic histocytosis localization which, to the best of our knowledge, had never been described before in association with PTC. Even if this aspect is not addressed in the present case report, it is worth noting that about 50% of the patients affected either by LCH or PTC are characterized by activating mutations of the proto-oncogene BRAF. This, along with other clinical studies, may warrant further biomolecular large-scale case study investigations in order to evaluate a possible connection between the 2 conditions and shed light on the etiology of these diseases, which are still largely unknown.
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Guarino
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Deborah Maria
authors.initials: DM
authors.lastname: Giusti
authors.affiliation: Department of Radiology, Oncology and Anatomy Pathology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Rubini
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Pasqualino
authors.initials: P
authors.lastname: Favoriti
authors.affiliation: Department of Radiology, Oncology and Anatomy Pathology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Fioravanti
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Filippo Maria
authors.initials: FM
authors.lastname: Di Matteo
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: D'Andrea
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: De Antoni
authors.affiliation: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Catania
keywords: Langherans cell hystiocytosis; hypopituitarism; papillary thyroid carcinoma