title: Blockade of PD-1 immunosuppression boosts CAR T-cell therapy.
abstract: The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication.
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.
authors.forename: Liza B
authors.initials: LB
authors.lastname: John
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Department of Pathology; University of Melbourne; Parkville, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia ; Department of Immunology; Monash University; Clayton, VIC Australia.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kershaw
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Department of Pathology; University of Melbourne; Parkville, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia ; Department of Immunology; Monash University; Clayton, VIC Australia.
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
keywords: PD-1 blockade; adoptive immunotherapy; cancer; chimeric antigen receptor; immune response