title: Association of greater intravenous volume infusion with shorter hospitalization for patients with post-ERCP pancreatitis.
abstract: OBJECTIVE
  There are no data specifically correlating early intravenous volume infusion (IVI) with the length of hospitalization for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).
  
  
  METHODS
  We conducted a retrospective cohort study of patients admitted within 24 h after ERCP to our institute with PEP. IVI during the first 24 h after ERCP was assessed. Primary outcome was severity of PEP, defined by length of hospitalization according to consensus guidelines: mild ≤ 3, moderate 4-10, and severe > 10 days.
  
  
  RESULTS
  Of 72 eligible patients, 41 (56.9%) had mild and 31 (43.1%) moderate/severe PEP. Both groups had comparable demographics, indications, and procedural factors except patients with moderate/severe PEP were older (median age 49 vs 36 years, P = 0.05) and more likely to be discharged and readmitted within the first 24 h (41.9% vs 14.6%, P < 0.01). Patients with mild PEP received significantly greater IVI during the first 24 h (2834 mL [2046, 3570] vs 2044 mL [1227, 2875], P < 0.02) and 50% more fluid post-ERCP (2270 mL [1435, 2961] vs 1515 [950-2350], P < 0.02) compared with those with at least moderate PEP.
  
  
  CONCLUSIONS
  In patients with PEP, greater IVI during the first 24 h after ERCP is associated with reduced length of hospitalization. Lower IVI was more commonly observed in individuals who were discharged and then readmitted during the first 24 h.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Sashidhar V
authors.initials: SV
authors.lastname: Sagi
authors.forename: Suzette
authors.initials: S
authors.lastname: Schmidt
authors.forename: Evan
authors.initials: E
authors.lastname: Fogel
authors.forename: Glen A
authors.initials: GA
authors.lastname: Lehman
authors.forename: Lee
authors.initials: L
authors.lastname: McHenry
authors.forename: Stuart
authors.initials: S
authors.lastname: Sherman
authors.forename: James
authors.initials: J
authors.lastname: Watkins
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Coté
mesh_terms: D000328:Adult; D000367:Age Factors; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D015331:Cohort Studies; D000077324:Crystalloid Solutions; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007902:Length of Stay; D008297:Male; D010195:Pancreatitis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy*; D019990:Perioperative Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions
keywords: endoscopic retrograde cholangiopancreatography; intravenous infusion; pancreatitis