title: The protective effect of lidocaine on septic rats via the inhibition of high mobility group box 1 expression and NF-κB activation.
abstract: Lidocaine, a common local anesthetic drug, has anti-inflammatory effects. It has demonstrated a protective effect in mice from septic peritonitis. However, it is unknown whether lidocaine has effects on high mobility group box 1 (HMGB1), a key mediator of inflammation. In this study, we investigated the effect of lidocaine treatment on serum HMGB1 level and HMGB1 expression in liver, lungs, kidneys, and ileum in septic rats induced by cecal ligation and puncture (CLP). We found that acute organ injury induced by CLP was mitigated by lidocaine treatment and organ function was significantly improved. The data also demonstrated that lidocaine treatment raised the survival of septic rats. Furthermore, lidocaine suppressed the level of serum HMGB1, the expression of HMGB1, and the activation of NF-κB p65 in liver, kidneys, lungs, and ileum. Taken together, these results suggest that lidocaine treatment exerts its protective effection on CLP-induced septic rats. The mechanism was relative to the inhibitory effect of lidocaine on the mRNA expression level of HMGB1 in multiple organs, release of HMGB1 to plasma, and activation of NF- κB.
authors.affiliation: Department of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Huan-Liang
authors.initials: HL
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Xing
authors.affiliation: Department of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Ying-Xue
authors.initials: YX
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Rong
authors.affiliation: Department of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Wei-Fu
authors.initials: WF
authors.lastname: Lei
authors.affiliation: Department of Neurosurgery, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors* / Q000097:blood / Q000235:genetics; D008012:Lidocaine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D016328:NF-kappa B / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism; D021381:Protein Transport / Q000187:drug effects; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality
chemical_list: D024243:HMGB1 Protein; D016328:NF-kappa B; D012333:RNA, Messenger; D008012:Lidocaine; D009195:Peroxidase