title: (31) P MR spectroscopic imaging combined with (1) H MR spectroscopic imaging in the human prostate using a double tuned endorectal coil at 7T.
abstract: OBJECTIVE
  Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both (1) H and (31) P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer.
  
  
  METHODS
  A two-element (1) H/(31) P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two-element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. (1) H MRSI and (31) P MRSI were acquired in vivo in prostate cancer patients.
  
  
  RESULTS
  The efficiency of the (1) H/(31) P coil is comparable to the dual channel (1) H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo (31) P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. (1) H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate.
  
  
  CONCLUSIONS
  (1) H MRSI and (31) P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for (1) H (quadrature) and (31) P (linear) without the need of cable traps and with negligible efficiency losses in the (1) H and (31) P channel.
authors.affiliation: Imaging Division, University Medical Center, Utrecht, Netherlands.
authors.forename: Mariska P
authors.initials: MP
authors.lastname: Luttje
authors.forename: Michel G M
authors.initials: MG
authors.lastname: Italiaander
authors.forename: Catalina S
authors.initials: CS
authors.lastname: Arteaga de Castro
authors.forename: Wybe J M
authors.initials: WJ
authors.lastname: van der Kemp
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.forename: Marco
authors.initials: M
authors.lastname: van Vulpen
authors.forename: Uulke A
authors.initials: UA
authors.lastname: van der Heide
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008280:Magnetics / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000493:pharmacokinetics; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D019275:Radiopharmaceuticals; D012007:Rectum; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers
chemical_list: D014408:Biomarkers, Tumor; D010761:Phosphorus Radioisotopes; D019275:Radiopharmaceuticals
keywords: 7 Tesla; magnetic resonance spectroscopy; phosphorus; prostate cancer; proton