title: Endocannabinoid signalling in neuronal migration.
abstract: The endocannabinoid (eCB) system consists of several endogenous lipids, their target CB1 and CB2 receptors and enzymes responsible for their synthesis and degradation. The most abundant eCB in the central nervous system (CNS), 2-arachidonoyl glycerol (2-AG), triggers a broad range of signalling events by acting on CB1, the most abundant G protein-coupled receptor in the CNS. The eCB system regulates many physiological processes including neurogenesis, axon guidance and synaptic plasticity. Recent studies have highlighted an additional important role for eCB signalling in neuronal migration, which is crucial to achieve the complex architecture and efficient wiring of the CNS. Indeed, eCB signalling controls migration both pre- and post-natally, regulating interneuron positioning in the developing cortex and hippocampus and the polarised motility of stem cell-derived neuroblasts. While these effects may contribute to cognitive deficits associated with cannabis consumption, they also provide potential opportunities for endogenous stem cell-based neuroregenerative strategies.
authors.affiliation: Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, UK.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, UK.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Falenta
authors.affiliation: Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address: giovanna.lalli@kcl.ac.uk.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Lalli
mesh_terms: D002465:Cell Movement / Q000502:physiology*; D063388:Endocannabinoids / Q000378:metabolism*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism*; D055495:Neurogenesis; D015398:Signal Transduction
chemical_list: D063388:Endocannabinoids
keywords: 2-AG; CB receptor; Endocannabinoid; Neuronal migration