title: The effect of laparoscopic sleeve gastrectomy with or without hiatal hernia repair on gastroesophageal reflux disease in obese patients.
abstract: BACKGROUND
  Obesity is an independent risk factor for gastroesophageal reflux disease (GERD), which is often associated with the presence of a hiatal hernia (HH). Despite increasing popularity of laparoscopic sleeve gastrectomy (LSG) in bariatric surgery, its effect on GERD is still unclear. The objective of this study was to evaluate the effect of LSG with or without hiatal hernia repair (HHR) on GERD in obese patients.
  
  
  METHODS
  Seventy-eight patients with HH underwent LSG with concomitant HHR (LSG+HHR group). Their data were compared with that of 102 patients without HH, who underwent only LSG (LSG-group). All patients underwent a standardized questionnaire, a double-contrast barium swallow, and an upper-gastrointestinal endoscopy before the surgical procedure and at least 6 months later.
  
  
  RESULTS
  At baseline, the prevalence of GERD symptoms and their frequency-intensity scores did not differ between groups. At follow up, there was a significant decrease in the prevalence of typical GERD symptoms only in the LSG-group (P = .003). LSG+HHR patients showed a significantly higher heartburn frequency-intensity score compared with LSG patients (P = .009).
  
  
  CONCLUSIONS
  This finding confirms that LSG has a beneficial effect on relieving GERD symptoms, although the underlying mechanisms are still unclear; conversely, the procedure of HHR did not produce any improvement in GERD symptoms.
authors.affiliation: Clinical and Experimental Medicine Department, Federico II University of Naples, Naples, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Santonicola
authors.affiliation: General and Endoscopic Surgery Unit, San Giovanni Bosco Hospital, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Angrisani
authors.affiliation: General and Endoscopic Surgery Unit, San Giovanni Bosco Hospital, Naples, Italy.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Cutolo
authors.affiliation: General and Endoscopic Surgery Unit, San Giovanni Bosco Hospital, Naples, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Formisano
authors.affiliation: Medicine and Surgery Department, University of Salerno, Salerno, Italy. Electronic address: piovino@unisa.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Iovino
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D015391:Gastroplasty / Q000379:methods*; D006551:Hernia, Hiatal / Q000150:complications / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010535:Laparoscopy; D008297:Male; D009765:Obesity / Q000150:complications / Q000601:surgery*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
keywords: Gastroesophageal reflux disease; Hiatal hernia repair; Laparoscopic sleeve gastrectomy; Obesity