title: Mesoporous materials and nanocrystals for enhancing the dissolution behavior of poorly water-soluble drugs.
abstract: Advanced drug delivery formulations are presently recognized as promising tools for overcoming the adverse physicochemical properties of conventional drug molecules, such as poor water solubility, which often leads to poor drug bioavailability. Oral drug delivery is considered as the easiest and most convenient route of drug administration. However, via the current trends utilizing combinatorial chemistry and high throughput screening in drug development, new drug molecules are moving towards lipophilic and poorly water-soluble large molecules, and the oral delivery route is becoming increasingly challenging. In this context, formulation of poorly soluble and/or permeable drugs using mesoporous materials and nanocrystals technology have proven to be highly successful due to the greater surface/volume ratio of these systems, resulting in improvements in dissolution and bioavailability, as well as enhanced drug permeability. This review addresses the issues of poorly water-soluble drugs with a major focus on recent developments in the application of the mesoporous materials (e.g., porous silicon and silica) and nanocrystals in drug delivery applications. In addition, we present several recent examples of the significant potential of these materials for the pharmaceutical field.
authors.forename: Helder A
authors.initials: HA
authors.lastname: Santos
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Tarja
authors.initials: T
authors.lastname: Limnell
authors.affiliation: Division of Pharmaceutical Technology, Faculty of Pharmacy, FI-00014 University of Helsinki, Finland. jouni.hirvonen@helsinki.fi.
authors.forename: Jouni
authors.initials: J
authors.lastname: Hirvonen
mesh_terms: D000818:Animals; D001682:Biological Availability; D017610:Calcium Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry*; D016062:Porosity; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D017610:Calcium Compounds; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D017640:Silicates; D014867:Water; C031293:calcium silicate