title: 3-oxoabolene and 1-oxocurcuphenol, aromatic bisabolanes from the sponge Myrmekioderma sp.
abstract: Two new aromatic bisabolane sesquiterpenes possessing an oxo functionality on the prenyl chain, (+)-3-oxoabolene (3) and (+)-l-oxocurcuphenol (4), along with two known sesquiterpenes, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from the sponge Myrmekioderma sp. The antiproliferative activity of 2-4 was determined and showed an interesting selectivity; i.e., a good activity against HT-29 cells with IC50s in the microM range, but a weak and incalculable toxicity against Hela and normal fibroblast cells.
authors.affiliation: School of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Yegdaneh
authors.affiliation: lnstitute of Marine Science, Burapha University, Chonburi 20131, Thailand.
authors.forename: Sumaitt
authors.initials: S
authors.lastname: Putchakarn
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Supreeya
authors.initials: S
authors.lastname: Yuenyongsawad
authors.affiliation: School of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghannadi
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C585923:1-oxocurcuphenol; C585922:3-oxoabolene; D000970:Antineoplastic Agents; D012717:Sesquiterpenes