title: [Clinical and pathological analysis of 41 cases of acute leukemia combined with intracranial hemorrhage].
abstract: This study was aimed to summarize the clinical and pathological features of patients with acute leukemia combined with intracranial hemorrhage. The clinical and pathological data of 41 adult patients diagnosed as acute leukemia in our hospital from 1953 to 1990 year were analyzed retrospectively. The results showed that there were 35 cases of AML, 6 cases of ALL; 9 cases in clinical hematologic remission, 32 cases in non-remission, 3 cases of AL with hypertension, 2 cases of AL with diabetes, 4 cases of AL with sepsis, 19 cases with WBC ≥ 100×10(9)/L; the pathologic examination showed 4 cases of AL accompanied with disseminated intravascular coagulation, 10 cases with prothrombin time INR ≥ 1.5, 26 cases with multifocal intracranial hemorrhage, 7 cases with single intracranial hemorrhage, 8 cases with diffused spotting intracranial hemorrhage; the examination also showed that 84 hemorrhage foci were found in 41 cases of AL, among them 46 foci located under cerebral cortex, 23 foci in cerebellum, 6 in basal ganglia, 5 foci in pons, 2 foci in thalamus, 2 foci in spinal cord. It is concluded that the intracranial hemorrhage is a major cause resulting in death of AL patients which should be think highly, and the diagnosis and treatment should be conducted through comprehensive analysis.
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China. E-mail: zhoufan611@sina.com.cn.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Su-Fen
authors.initials: SF
authors.lastname: Zhang
authors.affiliation: Department of Pathology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Song
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Yan-Qin
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Xi-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000473:pathology*; D007938:Leukemia / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult