title: Association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in individuals 65 years or more with diabetes from a Geriatric Service in Monterrey, Mexico.
abstract: OBJECTIVE
  Cognitive impairment and dementia are common geriatric syndromes in diabetic patients. Inflammation plays a crucial role in the pathophysiology of Alzheimer's disease and cognitive impairment. Cyclooxygenases (COX) 1 and 2 participate in inflammation. The polymorphism c.1-765G>C of the COX2 gene might be protective against cognitive decline in Mexicans with diabetes mellitus through its reduced promotor activity. To determine the association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in elderly adults with diabetes.
  
  
  METHODS
  Case-control study. We included diabetic patients from the Geriatric Clinic of General Hospital No. 17 who were over 65 years and accepted to participate. Cases were patients with a score of 24 or less on the Mini Mental Status Examination (MMSE) and with DSM IV criteria for dementia. Controls were those with MMSE scores of 25 or greater. Results We included 97 patients (50 cases and 47 controls). There were no differences regarding clinical and laboratory characteristics between cases and controls. The frequency of the C allele and the CG genotype was higher in controls than in cases and this difference remained significant in a multivariate analysis with an odds ratio of 0.012 (95% CI 0.001-0.091) and 0.009 (95% CI 0.001-0.076) in the bivariate and multivariate analysis, respectively, using the GG genotype frequency as a reference.
  
  
  CONCLUSIONS
  Cognitive impairment in Mexican patients with diabetes is associated with less exposure to the CG genotype of the c.1-765G>C polymorphism of COX2.
authors.affiliation: Servicio de Geriatría, UMAE 21, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México; Departamento de Posgrado, Universidad Juárez del Estado de Durango, México. Electronic address: edleon20@hotmail.com.
authors.forename: Enrique
authors.initials: E
authors.lastname: Díaz De León González
authors.affiliation: Departamento de Posgrado, Universidad Juárez del Estado de Durango, México; Centro Médico Nacional del Bajío No. 1, IMSS y Hospital Aranda de la Parra, León Guanajuato, México.
authors.forename: Hugo
authors.initials: H
authors.lastname: Gutiérrez Hermosillo
authors.affiliation: Servicio de Geriatría, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, San Luis Potosí, México.
authors.forename: Javier Armando
authors.initials: JA
authors.lastname: Cedillo Rodrígez
authors.affiliation: Departamento de Posgrado, Universidad Juárez del Estado de Durango, México.
authors.forename: Miguel Arturo
authors.initials: MA
authors.lastname: Reyes Romero
authors.affiliation: Departamento de Posgrado, Universidad Juárez del Estado de Durango, México.
authors.forename: Abelardo
authors.initials: A
authors.lastname: Camacho Luis
authors.affiliation: Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Palacios Corona
authors.affiliation: Departamento de Posgrado, Universidad Juárez del Estado de Durango, México.
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Burciaga Nava
authors.affiliation: Departamento de Posgrado, Universidad Juárez del Estado de Durango, México.
authors.forename: José Alejandro
authors.initials: JA
authors.lastname: Ríos Valles
authors.affiliation: Subdirección de Investigación, Facultad de Medicina, Universidad Autónoma de Nuevo León, México.
authors.forename: Hector Eloy
authors.initials: HE
authors.lastname: Tamez Pérez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D003704:Dementia / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D048909:Diabetes Complications / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D015999:Multivariate Analysis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: Cognitive impairment; Deterioro cognoscitivo; Polimorfismo c.1-765G>C del gen de la COX-2; c.1-765G>C polymorphism of the COX-2 gene