title: Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment.
abstract: OBJECTIVE
  To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment.
  
  
  RESULTS
  Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102 ± 37 pg/mL) were significantly higher (p = 0.050) compared to controls. CXCL-1 levels correlated significantly with age (p = 0.001) and RRD duration (p = 0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C.
  
  
  CONCLUSIONS
  The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR.
authors.affiliation: 2nd Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital , Thessaloniki, Macedonia , Greece .
authors.forename: Chrysanthos
authors.initials: C
authors.lastname: Symeonidis
authors.forename: Sofia
authors.initials: S
authors.lastname: Androudi
authors.forename: Tryfon
authors.initials: T
authors.lastname: Rotsos
authors.forename: Marilita M
authors.initials: MM
authors.lastname: Moschos
authors.forename: Efimia
authors.initials: E
authors.lastname: Souliou
authors.forename: Stavros A
authors.initials: SA
authors.lastname: Dimitrakos
authors.forename: Eudoxia
authors.initials: E
authors.lastname: Diza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D054360:Chemokine CXCL1 / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D058471:Subretinal Fluid / Q000378:metabolism*; D018630:Vitreoretinopathy, Proliferative / Q000150:complications / Q000175:diagnosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054360:Chemokine CXCL1
keywords: CXCL-1; GRO-α; proliferative vitreoretinopathy; rhegmatogenous retinal detachment; subretinal fluid