title: Association of sex with long-term outcomes after popliteal artery aneurysm repair.
abstract: BACKGROUND
  We compared initial and long-term outcomes between men and women after endovascular and open repair of popliteal artery aneurysms (PAAs).
  
  
  METHODS
  Between January 1993 and July 2011, 202 patients (185 men [92%]), underwent open (n = 186) or endovascular (n = 16) repair of a PAA. Data were retrospectively analyzed.
  
  
  RESULTS
  Significant differences in baseline characteristics were determined between men and women with regard to aneurysm diameter (men: 30 mm [range: 14-90]; women: 26 mm [range: 13-70]; P = 0.02) and age (men: 66 ± 10 years; women: 71 ± 9 years; P = 0.05). The 30-day mortality rate was 0% in both groups. No significant differences were determined concerning 30-day complications. The median follow-up was 55 months (range: 1-121 months) in men, compared with 35 months (range: 1-183 months) in women (P = 0.74). The primary patency rates at 1, 3, and 5 years were 88%, 82%, and 76% in men compared with 64%, 64%, and 48% in women, respectively (P = 0.007). The limb salvage rates in men at 1, 3, and 5 years were 97%, 97%, and 96%, and in women were 87%, 87%, and 87%, respectively (P = 0.07). When correcting for potential confounders with multivariable regression analysis, sex was independently associated with primary patency (hazard ratio: 2.98 [95% confidence interval: 1.39-6.42]; P = 0.005).
  
  
  CONCLUSIONS
  No significant differences between men and women were observed in 30-day mortality and morbidity rates after PAA repair. In the long run, women are associated with lower primary patency rates and a trend toward lower limb salvage rates compared to men.
authors.affiliation: Department of Vascular Surgery, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands. Electronic address: r.kropman@antoniusziekenhuis.nl.
authors.forename: Rogier H J
authors.initials: RH
authors.lastname: Kropman
authors.affiliation: Department of Vascular Surgery, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
authors.forename: Andrea
authors.initials: A
authors.lastname: van Meurs
authors.affiliation: Department of Vascular Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands.
authors.forename: Bram
authors.initials: B
authors.lastname: Fioole
authors.affiliation: Department of Radiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
authors.forename: Jan Albert
authors.initials: JA
authors.lastname: Vos
authors.affiliation: Department of Vascular Surgery, University Medical Center, Utrecht, The Netherlands.
authors.forename: Hjalmar C
authors.initials: HC
authors.lastname: van Santvoort
authors.affiliation: Department of Vascular Surgery, Catharina Hospital Eindhoven, The Netherlands.
authors.forename: Marc
authors.initials: M
authors.lastname: van Sambeek
authors.affiliation: Department of Vascular Surgery, University Medical Center, Utrecht, The Netherlands.
authors.forename: Frans L
authors.initials: FL
authors.lastname: Moll
authors.affiliation: Department of Vascular Surgery, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
authors.forename: Jean-Paul P M
authors.initials: JP
authors.lastname: de Vries
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000783:Aneurysm / Q000401:mortality / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011150:Popliteal Artery / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery; D016016:Proportional Hazards Models; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality