title: [Recommendations for the treatment of mixed episodes in current guidelines].
abstract: A literature search on the pharmacological treatment of acute bipolar mixed episodes in current guidelines shows that only seven of them address the acute management of mixed episodes as a separate condition, whereas the vast majority of these guidelines include the treatment of mixed episodes in the chapter of mania. As a general rule, most guidelines advise to stop antidepressant treatment and mention the superiority of valproate over lithium. Specific recommendations for the treatment of "mixed states" can be found in two guidelines, while specific recommendations for that of "mixed mania" are present in five of them. Recommendations for the treatment of "mixed depression" exist in only three guidelines. If some consensus may be found for the treatment of "mixed states" as a whole, recommendations for the treatment of "mixed mania" appear to be variable, whereas those for the treatment of "mixed depression" seem to be limited.
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France. Electronic address: jazorin@ap-hm.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: R
authors.initials: R
authors.lastname: Belzeaux
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: M
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: Pôle de psychiatrie des adultes, CHU Robert-Debré, Avenue du Général-Koenig, 51092 Reims cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Kaladjian
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: N
authors.initials: N
authors.lastname: Corréard
authors.affiliation: Pôle de psychiatrie centre, Hôpital de la Conception, Boulevard Baille, 13006 Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Dassa
authors.affiliation: Pôle de psychiatrie centre, Hôpital de la Conception, Boulevard Baille, 13006 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Dubois
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: M
authors.initials: M
authors.lastname: Maurel
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: J A
authors.initials: JA
authors.lastname: Micoulaud Franchi
authors.affiliation: Clinique de psychiatrie et de psychologie médicale, CHU Pasteur, 06002 Nice cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Pringuey
authors.affiliation: SHU psychiatrie adultes, Solaris, Hôpital Sainte-Marguerite, 13274 Marseille cedex 09, France.
authors.forename: E
authors.initials: E
authors.lastname: Fakra
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D015897:Comorbidity; D032921:Consensus; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003937:Diagnosis, Differential; D057915:Drug Substitution; D019983:Guideline Adherence; D006801:Humans; D018020:Lithium Compounds / Q000009:adverse effects / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D018692:Antimanic Agents; D018020:Lithium Compounds; D014635:Valproic Acid
keywords: Dépression mixte; Guidelines; Guidelines Recommendations; Manie mixte; Mixed depression; Mixed episode; Mixed mania; Mixed state; Recommandations; Épisode mixte; État mixte