title: Biodegradable, pH-responsive carboxymethyl cellulose/poly(acrylic acid) hydrogels for oral insulin delivery.
abstract: Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but rapidly swell in neutral artificial intestinal fluid (AIF), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in AIF. Oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6 h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. The relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Gao
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.forename: Xiangfu
authors.initials: X
authors.lastname: Song
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage* / Q000737:chemistry; D011817:Rabbits; D051381:Rats
chemical_list: D000180:Acrylic Resins; D063566:Biodegradable Plastics; D020100:Hydrogels; D007328:Insulin; C006903:carbopol 940; D002266:Carboxymethylcellulose Sodium
keywords: biodegradable hydrogels; controlled release; oral delivery; pH-responsive