title: Old molecules, new biochemistry.
abstract: The study by Dulcey and colleagues in this issue of Chemistry & Biology changes our perception of the pathway of 2-alkyl-4-hydroxyquinoline biosynthesis by the opportunistic pathogen Pseudomonas aeruginosa and suggests that the biosynthetic protein complex PqsBC is a potential antibacterial target.
authors.affiliation: Institute of Molecular Microbiology and Biotechnology, University of Münster, Corrensstrasse 3, D-48149 Münster, Germany. Electronic address: fetzner@uni-muenster.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Fetzner
authors.affiliation: Institute of Molecular Microbiology and Biotechnology, University of Münster, Corrensstrasse 3, D-48149 Münster, Germany.
authors.forename: Steffen L
authors.initials: SL
authors.lastname: Drees
mesh_terms: D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D053898:Biosynthetic Pathways; D055808:Drug Discovery; D006801:Humans; D006912:Hydroxyquinolines / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D006912:Hydroxyquinolines; C034010:4-hydroxyquinoline