title: Association between septal deviation and sinonasal papilloma.
abstract: Sinonasal papilloma is a common benign epithelial tumor of the sinonasal tract and accounts for 0.5% to 4% of all nasal tumors. The etiology of sinonasal papilloma remains unclear, although human papilloma virus has been proposed as a major risk factor. Other etiological factors, such as anatomical variations of the nasal cavity, may be related to the pathogenesis of sinonasal papilloma, because deviated nasal septum is seen in patients with chronic rhinosinusitis. We, therefore, investigated the involvement of deviated nasal septum in the development of sinonasal papilloma. Preoperative computed tomography or magnetic resonance imaging findings of 83 patients with sinonasal papilloma were evaluated retrospectively. The side of papilloma and the direction of septal deviation showed a significant correlation. Septum deviated to the intact side in 51 of 83 patients (61.4%) and to the affected side in 18 of 83 patients (21.7%). Straight or S-shaped septum was observed in 14 of 83 patients (16.9%). Even after excluding 27 patients who underwent revision surgery and 15 patients in whom the papilloma touched the concave portion of the nasal septum, the concave side of septal deviation was associated with the development of sinonasal papilloma (p = 0.040). The high incidence of sinonasal papilloma in the concave side may reflect the consequences of the traumatic effects caused by wall shear stress of the high-velocity airflow and the increased chance of inhaling viruses and pollutants. The present study supports the causative role of human papilloma virus and toxic chemicals in the occurrence of sinonasal papilloma.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nomura
authors.forename: Takenori
authors.initials: T
authors.lastname: Ogawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sugawara
authors.forename: Yohei
authors.initials: Y
authors.lastname: Honkura
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Oshima
authors.forename: Kazuya
authors.initials: K
authors.lastname: Arakawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oshima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Katori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D052140:Human papillomavirus 11 / Q000378:metabolism; D052163:Human papillomavirus 6 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000002:abnormalities* / Q000473:pathology*; D010212:Papilloma / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012852:Sinusitis / Q000150:complications / Q000503:physiopathology*