title: Liposome encapsulation of curcumin: physico-chemical characterizations and effects on MCF7 cancer cell proliferation.
abstract: The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound. We demonstrated that liposomal preparations to deliver curcumin increase its bioavailability. Liposomes composed of salmon's lecithin also improved curcumin bioavailability compared to those constituted of rapeseed and soya lecithins. A real-time label-free cell analysis system based on real-time cell impedance monitoring was used to investigate the in vitro cytotoxicity of liposomal preparations.
authors.affiliation: Université de Lorraine, Laboratoire d'ingénierie des Biomolecules, EA 4367, France.
authors.forename: M
authors.initials: M
authors.lastname: Hasan
authors.affiliation: Université de Lorraine, Laboratoire d'ingénierie des Biomolecules, EA 4367, France.
authors.forename: N
authors.initials: N
authors.lastname: Belhaj
authors.affiliation: Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex 54506, France; CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy, France.
authors.forename: H
authors.initials: H
authors.lastname: Benachour
authors.affiliation: Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex 54506, France; CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy, France; CNRS, GdR 3049 "Médicaments Photoactivables - Photochimiothérapie (PHOTOMED)", France; Centre Alexis Vautrin, CRLCC, Avenue de Bourgogne, Vandœuvre-lès-Nancy Cedex 54519, France.
authors.forename: M
authors.initials: M
authors.lastname: Barberi-Heyob
authors.affiliation: Aix-Marseille Univ, LBA, F-13916 Marseille, France; IFSTTAR, LBA, F-13916 Marseille, France.
authors.forename: C J F
authors.initials: CJ
authors.lastname: Kahn
authors.affiliation: Department of Chemical Engineering, SWNG Engineering Center, Rm 2C02, University of South Carolina, 301 South Main Street, Columbia, SC 29208, United States.
authors.forename: E
authors.initials: E
authors.lastname: Jabbari
authors.affiliation: Université de Lorraine, Laboratoire d'ingénierie des Biomolecules, EA 4367, France.
authors.forename: M
authors.initials: M
authors.lastname: Linder
authors.affiliation: Université de Lorraine, Laboratoire d'ingénierie des Biomolecules, EA 4367, France. Electronic address: elmira.arab-tehrany@univ-lorraine.fr.
authors.forename: E
authors.initials: E
authors.lastname: Arab-Tehrany
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D001682:Biological Availability; D029741:Brassica rapa / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D054709:Lecithins / Q000737:chemistry; D008081:Liposomes; D061986:MCF-7 Cells; D053758:Nanoparticles; D012474:Salmon; D013025:Glycine max / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D054709:Lecithins; D008081:Liposomes; D003474:Curcumin
keywords: Cancer cells; Drug encapsulation; Lecithin; Nanoliposome