title: Bacterial virulence and Fis: adapting regulatory networks to the host environment.
abstract: Pathogenic bacteria have to cope with adverse conditions, such as the host environment and host defense reactions. To adapt quickly to environmental changes, pathogens have developed complex regulatory networks that ensure adequate expression of their virulence genes. Recent evidence suggests that Fis, an abundant nucleoid-associated protein transiently produced during early exponential growth, plays a major role in these networks in several pathogenic bacteria. This review focuses on two enterobacteria, Salmonella enterica and Dickeya dadantii, that inhabit distinct ecological niches to illustrate how Fis uses different strategies to coordinate virulence gene expression, depending on the bacterial lifestyle.
authors.affiliation: Université Lyon 1, F-69622 Villeurbanne, France; INSA de Lyon, F-69621 Villeurbanne, France; CNRS UMR5240 Microbiologie, Adaptation et Pathogénie, Villeurbanne, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Duprey
authors.affiliation: Université Lyon 1, F-69622 Villeurbanne, France; INSA de Lyon, F-69621 Villeurbanne, France; CNRS UMR5240 Microbiologie, Adaptation et Pathogénie, Villeurbanne, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Reverchon
authors.affiliation: Université Lyon 1, F-69622 Villeurbanne, France; INSA de Lyon, F-69621 Villeurbanne, France; CNRS UMR5240 Microbiologie, Adaptation et Pathogénie, Villeurbanne, France. Electronic address: william.nasser@insa-lyon.fr.
authors.forename: William
authors.initials: W
authors.lastname: Nasser
mesh_terms: D000222:Adaptation, Physiological; D004755:Enterobacteriaceae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D035021:Factor For Inversion Stimulation Protein / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D053263:Gene Regulatory Networks; D054884:Host-Pathogen Interactions; D014774:Virulence
chemical_list: D035021:Factor For Inversion Stimulation Protein
keywords: DNA supercoiling; Dickeya; Fis; Salmonella; nucleoid-associated protein; virulence