title: Expedient synthesis of C3-symmetric hexasubstituted benzenes via Nicholas reaction/[2 + 2 + 2] cycloaddition. new platforms for molecular recognition.
abstract: An expedient methodology to synthesize macrocyclic compounds in one step based on the Nicholas reaction is disclosed. The key step features two intermolecular reactions followed by an intramolecular reaction from the starting dicobalt hexacarbonyl-propargylic complex. The macrocycles obtained were modified through [2 + 2 + 2] cycloaddition, generating two new C3-symmetric hexasubstituted benzene structures suitable for molecular recognition purposes.
authors.affiliation: Instituto de Productos Naturales y Agrobiología , Consejo Superior de Investigaciones Científicas (CSIC), Avda. Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
authors.forename: Romen
authors.initials: R
authors.lastname: Carrillo
authors.forename: Tomás
authors.initials: T
authors.lastname: Martín
authors.forename: Matías
authors.initials: M
authors.lastname: López-Rodríguez
authors.forename: Fernando Pinacho
authors.initials: FP
authors.lastname: Crisóstomo
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D061565:Cycloaddition Reaction; D004578:Electron Spin Resonance Spectroscopy; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D047028:Macrocyclic Compounds