title: Intracerebroventricular administration of novel glucagon-like peptide suppresses food intake in chicks.
abstract: Glucagon-related peptides such as glucagon, glucagon-like peptide-1, and oxyntomodulin suppress food intake in mammals and birds. Recently, novel glucagon-like peptide (GCGL) was identified from chicken brain, and a comparatively high mRNA expression level of GCGL was detected in the hypothalamus. A number of studies suggest that the hypothalamus plays a critical role in the regulation of food intake in mammals and birds. In the present study, we investigated whether GCGL is involved in the central regulation of food intake in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of GCGL in chicks significantly suppressed food intake. Plasma glucose level was significantly decreased by GCGL, whereas plasma corticosterone level was not affected. Central administration of a corticotrophin-releasing factor (CRF) receptor antagonist, α-helical CRF, attenuated GCGL-suppressed food intake. It seems likely that CRF receptor is involved in the GCGL-induced anorexigenic pathway. All our findings suggest that GCGL functions as an anorexigenic peptide in the central nervous system of chicks.
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan. Electronic address: honda@tiger.kobe-u.ac.jp.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Honda
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Takaoki
authors.initials: T
authors.lastname: Saneyasu
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Shimatani
authors.affiliation: Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Aoki
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Kiwako
authors.initials: K
authors.lastname: Nakanishi
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamisoyama
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002645:Chickens; D003345:Corticosterone / Q000097:blood; D004435:Eating / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1 / Q000494:pharmacology*; D054795:Incretins / Q000494:pharmacology; D008297:Male; D053772:Oxyntomodulin / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000097:blood
chemical_list: D001067:Appetite Depressants; D001786:Blood Glucose; D054795:Incretins; D053772:Oxyntomodulin; D018019:Receptors, Corticotropin-Releasing Hormone; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D003345:Corticosterone
keywords: Appetite; Chicken; Corticosterone; Food intake; Glucagon