title: Oligoclonal and monoclonal bands after single autologous stem cell transplant in patients with multiple myeloma: impact on overall survival and progression-free survival.
abstract: Abstract Recently, the occurrence of oligoclonal and monoclonal bands (OB/MB) unrelated to the original clone has been reported in patients with multiple myeloma who undergo autologous stem cell transplant (ASCT) and/or receive treatment with novel agents. The aim of our study was to assess the impact of OB/MB occurrence on overall (OS) and progression-free survival (PFS) for patients with MM undergoing single ASCT at our institution. All consecutive patients with documented MM undergoing single ASCT from January 2000 to December 2012 were evaluated. Ninety-nine patients (11.8%) developed OB/MB at day 100 post-ASCT (32.3%, OB and 67.7%, MB). Multivariate analysis identified the development of OBs/MBs as an independent favorable prognostic factor for OS and PFS (p = 0.008 and 0.012, respectively). In conclusion, the occurrence of OB/MB is an important prognostic factor in patients with MM who undergo ASCT. Its impact on clinical outcomes should be prospectively validated and its biological significance further elucidated.
authors.affiliation: Princess Margaret Cancer Center, Department of Medical Oncology and Hematology , Toronto, ON , Canada.
authors.forename: Victor H
authors.initials: VH
authors.lastname: Jimenez-Zepeda
authors.forename: Donna E
authors.initials: DE
authors.lastname: Reece
authors.forename: Suzanne
authors.initials: S
authors.lastname: Trudel
authors.forename: Norman
authors.initials: N
authors.lastname: Franke
authors.forename: Andrew
authors.initials: A
authors.lastname: Winter
authors.forename: Christine
authors.initials: C
authors.lastname: Chen
authors.forename: Rodger
authors.initials: R
authors.lastname: Tiedemann
authors.forename: Vishal
authors.initials: V
authors.lastname: Kukreti
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood*; D018450:Disease Progression; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D043025:Oligoclonal Bands; D011379:Prognosis; D012074:Remission Induction; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D043025:Oligoclonal Bands
keywords: Multiple myeloma (MM); monoclonal gammopathy of undetermined significance (MGUS); oligoclonal bands