title: Direct visualization of in vitro drug mobilization from Lescol XL tablets using two-dimensional (19)F and (1)H magnetic resonance imaging.
abstract: This article reports the application of in vitro multinuclear ((19)F and (1)H) two-dimensional magnetic resonance imaging (MRI) to study both dissolution media ingress and drug egress from a commercial Lescol XL extended release tablet in a United States Pharmacopeia Type IV (USP-IV) dissolution cell under pharmacopoeial conditions. Noninvasive spatial maps of tablet swelling and dissolution, as well as the mobilization and distribution of the drug are quantified and visualized. Two-dimensional active pharmaceutical ingredient (API) mobilization and distribution maps were obtained via (19)F MRI. (19)F API maps were coregistered with (1)H T2-relaxation time maps enabling the simultaneous visualization of drug distribution and gel layer dynamics within the swollen tablet. The behavior of the MRI data is also discussed in terms of its relationship to the UV drug release behavior.
authors.affiliation: Department of Chemical Engineering & Biotechnology, University of Cambridge , Cambridge, CB2 3RA, United Kingdom.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Lynn F
authors.initials: LF
authors.lastname: Gladden
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mantle
mesh_terms: D003692:Delayed-Action Preparations; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry* / Q000378:metabolism; D000077340:Fluvastatin; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D013607:Tablets / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D013607:Tablets; D000077340:Fluvastatin