title: Doppler ultrasound study of penis in men with systemic sclerosis: a correlation with Doppler indices of renal and digital arteries.
abstract: Erectile dysfunction (ED) prevalence in male systemic sclerosis (SSc) is high and its pathogenesis is unclear. The aim of the study is to assess correlation between Doppler ultrasound indices of penis and kidneys or digital arteries in male systemic sclerosis. Fourteen men with systemic sclerosis were enrolled in this study. Erectile function was investigated by the International Index of Erectile Function-5. Peak systolic velocity, end diastolic velocity, resistive index, pulsative index, and systolic/diastolic ratio were measured on the cavernous arteries at the peno-scrotal junction in the flaccid state, on the interlobar artery of both kidneys and all ten proper palmar digital arteries. Ten (71 percent) patients have an International Index of Erectile Function-5 less than 21. Reduction of penis peak systolic velocity was observed in all SSc subjects. Doppler indices of cavernous arteries correlate with the International Index of Erectile Function-5. The renal and digital arteries resistive index demonstrated a good correlation (p less than 0.0001) with International Index of Erectile Function-5. A positive correlation exists between penis and kidney arteries Doppler indices: end diastolic velocity (p less than 0.05, r=0.54), resistive index (p less than 0.0001, r=0.90), systolic/diastolic ratio (p less than 0.01, r=0.69). A positive correlation was observed between penis and digital arteries Doppler indices: peak systolic velocity (p less than 0.01, r=0.68), end diastolic velocity (p less than 0.01, r=0.75), resistive index (p less than 0.001, r=0.79), systolic/diastolic ratio (p less than 0.05, r=0.59). A correlation exists between arterial impairment of penis and renal or digital arteries.
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Rosato
authors.affiliation: Department of Clinical Medicine, Nephrology Unit, Sapienza University of Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Barbano
authors.affiliation: Department of Clinical Medicine, Nephrology Unit, Sapienza University of Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gigante
authors.affiliation: Department of Clinical Medicine, Nephrology Unit, Sapienza University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Cianci
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Molinaro
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Quarta
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Digiulio
authors.affiliation: Department of Radiological, Oncological and Anatomical-pathologic Sciences, Sapienza University of Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Messineo
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pisarri
authors.affiliation: Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Salsano
mesh_terms: D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging; D007172:Erectile Dysfunction / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply*; D012595:Scleroderma, Systemic / Q000503:physiopathology*; D018608:Ultrasonography, Doppler / Q000379:methods*