title: Membranous nephropathy with acquired factor V inhibitor: a case report.
abstract: BACKGROUND
  Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. In contrast, acquired factor V inhibitor is a rare bleeding disorder.
  
  
  METHODS
  A 62-year-old Asian man with a history of cerebral hemorrhage, purpura, eosinophilia and hyper immunoglobulin E syndrome developed proteinuria. The bleeding disorder was diagnosed with acquired factor V inhibitors. A renal biopsy revealed that he suffered from membranous nephropathy with glomerular endothelial damage which is reported to be involved in another factor disorder. After the steroid administration, the coagulation test and proteinuria were improved.
  
  
  CONCLUSIONS
  The presence of factor V inhibitors may have been involved in the development of membranous nephropathy.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. s-kita@md.okayama-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kitamura
authors.forename: Mahito
authors.initials: M
authors.lastname: Misawa
authors.forename: Sayaka
authors.initials: S
authors.lastname: Namba
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuji
authors.forename: Rikako
authors.initials: R
authors.lastname: Torigoe
authors.forename: Midori
authors.initials: M
authors.lastname: Shima
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005165:Factor V / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000150:complications / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000473:pathology*
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D005165:Factor V