title: [Evidence-based study of chromate exposed workers' health surveillance indexes].
abstract: OBJECTIVE
  The health surveillance proposal for chromate exposed workers was provided and analyzed on the evidence-based study and then to be improved.
  
  
  METHODS
  Firstly, the related literatures were searched about liver damage, micronuclei, urinary chromium and hexavalent chromium exposure in Evidence Based Medicine Reviews such as Cochran library, OVID Medline, Web of knowledge in December 2011; and then, these literatures were reviewed in according to inclusion and exclusion criteria; 22 articles totally were retrieved, evaluated and classified in according to the grading standard by Oxford Centre for Evidence-based Medicine.Finally, field epidemiological investigation was further adopted to confirm the efficiency and feasibility of this proposal, combined with cost-effectiveness analysis:the ratio of total cost divided survival years was used to express the cost-effectiveness.
  
  
  RESULTS
  Only the glutamic pyruvic transaminase test could not reflect liver damage caused by chromate exposure well; Urinary chromium correlated well with the index reflecting body damage caused by chromate exposure; Binucleated cells micronucleus index in peripheral blood lymphocyte could reflect the genetic damage caused by chromate exposure. As for health economic evaluation of chromate lung cancer, the value of cost/effectiveness was ¥42 321.61 per year that was far below the value of common people (¥252 868.97 per year) .
  
  
  CONCLUSIONS
  It was suggested that serum glutamic pyruvic transaminase test should be replaced by liver function test, urinary chromium should be classified as a compulsory index and binucleated cells micronucleus index in peripheral blood lymphocyte should be supplied as a recommended index.
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University,Beijing 100091, China.
authors.forename: Yong-en
authors.initials: YE
authors.lastname: Gu
authors.forename: Qin
authors.initials: Q
authors.lastname: Qian
authors.forename: Shan-fa
authors.initials: SF
authors.lastname: Yu
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Zu-chang
authors.initials: ZC
authors.lastname: Zhao
authors.forename: Yan-shuang
authors.initials: YS
authors.lastname: Song
authors.forename: Tian
authors.initials: T
authors.lastname: Chen
authors.forename: Jing-Lin
authors.initials: JL
authors.lastname: Yang
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Email: jiaguangjia@bjmu.edu.cn.
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D002840:Chromates / Q000652:urine*; D019317:Evidence-Based Medicine; D006801:Humans; D015162:Micronucleus Tests; D016273:Occupational Exposure; D011159:Population Surveillance
chemical_list: D002840:Chromates; D000410:Alanine Transaminase