title: Synthesis of new 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones under catalyst-free and solvent-free conditions.
abstract: Several new 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones were synthesized via the three-component condensation reaction of aldehydes, aromatic amines, and ethyl pyruvate under catalyst-free and solvent-free conditions. Also, 5-(4-hydroxyl-3-nitrophenyl)-1-(4-methoxy-phenyl)-3-(4-methoxyphenylamino)-1,5-dihydro-pyrrol-2-one was synthesized using oxime instead of aldehyde. The eco-friendly, simple procedure, green procedure, catalyst-free and solvent-free conditions, short reaction times, and high yields of the products are the advantages of this method.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Persian Gulf University, 75169 , Bushehr, Iran, khniknam@gmail.com.
authors.forename: Khodabakhsh
authors.initials: K
authors.lastname: Niknam
authors.forename: Sanaz
authors.initials: S
authors.lastname: Mojikhalifeh
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D011773:Pyruvates / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D011758:Pyrroles; D011773:Pyruvates; C046522:ethyl pyruvate