title: [Pain management in patients with chronic kidney disease].
abstract: Chronic kidney disease (CKD), defined by abnormalities in kidney function or damage stable for more than three months, is a relatively common disease in Japan. A high prevalence of pain-associated disease is reported in the CKD population. Thus, there is ample opportunity to manage pain in patients with CKD in ordinary clinical practice. When administering analgesics to patients with CKD, we should be careful about the status of renal function and the renal excretion rates of parent drug and/or its metabolites, to prevent drug accumulation and increased risk of toxicity. Furthermore, certain analgesics can increase the risk of acute kidney injury and they should be avoided in CKD patients. The aim of this article is to review the considerations needed for pain management in CKD patients.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku 783-8505.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawano
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku 783-8505.
authors.forename: Masataka
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control; D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000506:poisoning; D001778:Blood Coagulation Disorders; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D059408:Pain Management / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology; D012720:Severity of Illness Index
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local