title: Comparison of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations after first-line treatment in Hodgkin's lymphoma.
abstract: OBJECTIVE
  Fluorine 18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) has been reported to have a wide-ranging positive predictive value (PPV) in the literary data on Hodgkin's lymphoma after first-line therapy. This study was carried out to compare the usefulness of the International Harmonization Project, London and Gallamini criteria in the interpretation of F-FDG PET/CT examinations for this indication.
  
  
  METHODS
  Data from 66 patients with a median follow-up care of 54 months were evaluated. The initial stage had been I-II in the case of 45 patients and III-IV in the case of 21 patients.
  
  
  RESULTS
  The analysis based on the International Harmonization Project criteria resulted in a negative predictive value (NPV) of 98.0% and a PPV of 62.5%. Using mediastinal blood pool and liver activity as the thresholds for the London criteria, the NPV and PPV were 98.0 and 62.5% and 98.1 and 71.4%, respectively. Considering only those lesions with F-FDG uptake that was markedly higher than liver uptake as positive, the NPV and PPV were 94.7 and 88.9%, respectively. The analysis based on the Gallamini criteria resulted in an NPV of 96.2% and a PPV of 69.2%.
  
  
  CONCLUSIONS
  Using the London criteria with liver activity as the threshold seems to be a good approach for the interpretation of post-treatment F-FDG PET/CT studies because of its high accuracy and simplicity.
authors.affiliation: aPozitron PET/CT Centre bNational Institute of Oncology cDepartment of Nuclear Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Kornélia
authors.initials: K
authors.lastname: Kajáry
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Molnár
authors.forename: Tamás
authors.initials: T
authors.lastname: Györke
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Szakáll
authors.forename: Péter
authors.initials: P
authors.lastname: Molnár
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lengyel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000592:standards*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18