title: Pre-chemotherapy abiraterone acetate. A proposal of a treatment algorithm in castration resistant prostate cancer.
abstract: BACKGROUND
  Prostate cancer treatment remains a challenge for the urologist. Medical control in locally advanced or metastatic prostate cancer is usually performed with LHRH analogues and/or antiandrogens. Different treatments have been proposed when there is biochemical and clinical progression of the disease and other new ones have changed the patients' perspective and life expectancy.
  
  
  OBJECTIVE
  This review has aimed to establish the current role of Abiraterone Acetate in the treatment of castration-resistant prostate cancer and facilitate decision-making by the Urologist by means of a Treatment Algorithm.
  A search of current evidence on Abiraterone treatment in patients with castration- resistant metastatic prostate cancer was performed in PubMed, mainly analyzing those studies designed as clinical trials. In addition, we reviewed and updated the role of hormone therapy and androgen receptors in prostate cancer.
  
  
  RESULTS
  There are currently basically two clinical trials that demonstrate the effectiveness of Abiraterone in metastatic prostate cancer compared to placebo. The study COU-AA 302 shows a clear benefit with Abiraterone prior to chemotherapy in patients with castration-resistant prostate cancer, this making it possible to establish an algorithm for initial treatment that facilitates decision-making by the urologist.
  
  
  CONCLUSIONS
  Abiraterone is a pre-chemotherapy treatment option in selected patients with castration resistant metastatic prostate cancer, although it is necessary to improve the cost and to design more multicenter clinical trials to optimize the cost/benefit ratio.
authors.affiliation: UGC de Urología, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada, Granada, España. Electronic address: arrabalp@ono.com.
authors.forename: M
authors.initials: M
authors.lastname: Arrabal-Martín
authors.affiliation: UGC de Urología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: F
authors.initials: F
authors.lastname: Anglada-Curado
authors.affiliation: UGC de Urología, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Cózar-Olmo
authors.affiliation: UGC de Urología, Hospital Regional Carlos Haya, Málaga, España.
authors.forename: J
authors.initials: J
authors.lastname: Soler-Martínez
authors.affiliation: UGC de Urología, Hospital Universitario Ciudad de Jaén, España.
authors.forename: J
authors.initials: J
authors.lastname: Moreno-Jiménez
authors.affiliation: UGC de Urología, Hospital Universitario Macarena, Sevilla, España.
authors.forename: J
authors.initials: J
authors.lastname: Castiñeiras-Fernández
authors.affiliation: UGC de Urología, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ledo-Cepero
authors.affiliation: UGC de Urología, Hospital de Jerez de la Frontera, Cádiz, España.
authors.forename: P
authors.initials: P
authors.lastname: Beardo-Villar
authors.affiliation: UGC de Urología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Requena-Tapia
authors.affiliation: UGC de Urología, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada, Granada, España.
authors.forename: A
authors.initials: A
authors.lastname: Zuluaga-Gómez
mesh_terms: D000069501:Abiraterone Acetate / Q000627:therapeutic use*; D000465:Algorithms; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D013254:Steroid 17-alpha-Hydroxylase; D000069501:Abiraterone Acetate
keywords: Abiraterona; Abiraterone; Androgens; Andrógenos; Castration resistant prostatic cancer; Cáncer de próstata resistente a la castración