title: A general strategy for organocatalytic activation of C-H bonds via photoredox catalysis: direct arylation of benzylic ethers.
abstract: Direct C-H functionalization and arylation of benzyl ethers has been accomplished via photoredox organocatalysis. The productive merger of a thiol catalyst and a commercially available iridium photoredox catalyst in the presence of household light directly affords benzylic arylation products in good to excellent yield. The utility of this methodology is further demonstrated in direct arylation of 2,5-dihydrofuran to form a single regioisomer.
authors.affiliation: Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
authors.forename: Katrine
authors.initials: K
authors.lastname: Qvortrup
authors.forename: Danica A
authors.initials: DA
authors.lastname: Rankic
authors.forename: David W C
authors.initials: DW
authors.lastname: MacMillan
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes
chemical_list: D001593:Benzyl Compounds; D004987:Ethers; D005663:Furans