title: Human relevance of NRAS/BRAF mouse melanoma models.
abstract: Melanoma is a major problem for many individuals worldwide. Although no effective treatment is available, promising new strategies are being developed. A better understanding of the inner workings of the disease would undoubtedly lead to improved treatments. Mouse melanoma models have been used to elucidate many key regulatory pathways involved in melanoma initiation and progression, and models with mutations in the oncogenes RAF and RAS have been particularly informative. Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma.
authors.affiliation: Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; CNRS UMR3347, France; INSERM U1021, France.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Conde-Perez
authors.affiliation: Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; CNRS UMR3347, France; INSERM U1021, France. Electronic address: lionel.larue@curie.fr.
authors.forename: Lionel
authors.initials: L
authors.lastname: Larue
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence; D020558:GTP Phosphohydrolases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D048493:Proto-Oncogene Proteins B-raf; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human
keywords: Initiation; Melanomagenesis; PTEN; Progression; p16(INK4A); β-Catenin