title: Thrombotic Thrombocytopenic Purpura with Reversible Neurological Features: Brain Diffusion MRI with ADC Map, Spect and EEG Findings. A Case Report.
abstract: Although nervous system involvement is common in thrombotic thrombocytopenic purpura (TTP), abnormalities on computerized tomography, magnetic resonance imaging and electroencephalography are not encountered so frequently and if present, these abnormalities are often reversible. We describe a 39-year-old woman with recurring transient focal neurological findings found to have laboratory findings consistent with TTP. In cerebral diffusion weighted images (DWI), diffuse cortical hyperintensity was noted in right frontal lobe, but the ADC (apparent diffusion coefficient) map was normal. Electroencephalography demonstrated lateralized slowing and repeated DWI showed diffuse cortical hyperintensity in the right hemisphere. SPECT showed luxury perfusion in the right hemisphere areas. The patient's condition resolved with plasmapheresis. Our patient illustrates that diffuse hemispheric involvement can be seen in DWI and EEG, and SPECT may show luxury perfusion after resolution of neurological findings in TTP cases. To our knowledge, this is the first TTP case in which the ADC map was normal.
authors.affiliation: Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center; Adana, Turkey - wvdeniz@superonline.com.
authors.forename: D
authors.initials: D
authors.lastname: Yerdelen
authors.forename: B K
authors.initials: BK
authors.lastname: Göksel
authors.forename: T
authors.initials: T
authors.lastname: Yıldırım
authors.forename: M
authors.initials: M
authors.lastname: Karataş
authors.forename: S
authors.initials: S
authors.lastname: Karaca
authors.forename: M
authors.initials: M
authors.lastname: Reyhan
authors.forename: H
authors.initials: H
authors.lastname: Ozdoğu