title: Alkaloids from an endophytic streptomyces sp. YIM66017.
abstract: Three alkaloids, flavensomycinoic acid (1), a linear polyketide, alpiniamide (2), and cyclo (L-Trp-L-Ala) (3), were isolated from the culture filtrate of endophytic Streptomyces sp. YIM66017 from Alpinia oxyphylla. Their structures were elucidated by spectroscopic analysis and the structure of 1 was confirmed by X-ray crystallographic analysis. Compound 1 was isolated from a natural source for the first time, and compound 2 is a new compound. Compound 1 showed cytotoxicity to MCF-7 with an IC50 value of 17.0 microM.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Jucheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Peng
authors.affiliation: Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D032429:Alpinia / Q000382:microbiology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents