title: Proteomics in immunity and herpes simplex encephalitis.
abstract: The genetic theory of infectious diseases has proposed that susceptibility to life-threatening infectious diseases in childhood, occurring in the course of primary infection, results mostly from individually rare but collectively diverse single-gene variants. Recent evidence of an ever-expanding spectrum of genes involved in susceptibility to infectious disease indicates that the paradigm has important implications for diagnosis and treatment. One such pathology is childhood herpes simplex encephalitis, which shows a pattern of rare but diverse disease-disposing genetic variants. The present report shows how proteomics can help to understand susceptibility to childhood herpes simplex encephalitis and other viral infections, suggests that proteomics may have a particularly important role to play, emphasizes that variation over the population is a critical issue for proteomics and notes some new challenges for proteomics and related bioinformatics tools in the context of rare but diverse genetic defects.
authors.affiliation: Immunology Unit, IdiPAZ Institute for Health Research, La Paz University Hospital, 261 Pº Castellana, Madrid 28046, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Pérez de Diego
authors.forename: Claire
authors.initials: C
authors.lastname: Mulvey
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
authors.forename: Jasminka
authors.initials: J
authors.lastname: Godovac-Zimmermann
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D020803:Encephalitis, Herpes Simplex / Q000235:genetics / Q000276:immunology*; D059472:Exome; D006801:Humans; D007109:Immunity; D040901:Proteomics / Q000379:methods*