title: A small molecule for controlled generation of reactive oxygen species (ROS).
abstract: Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS.
authors.affiliation: Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road Pashan, Pune 411 008, Maharashtra, India.
authors.forename: Allimuthu T
authors.initials: AT
authors.lastname: Dharmaraja
authors.forename: Harinath
authors.initials: H
authors.lastname: Chakrapani
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006207:Half-Life; D006861:Hydrogen Peroxide; D008954:Models, Biological; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000138:chemical synthesis* / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry
chemical_list: C000589994:5-(4-nitrobenzyloxy)-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione; D000873:Anthracenes; D009578:Nitrobenzenes; D017382:Reactive Oxygen Species; D013481:Superoxides; D006861:Hydrogen Peroxide