title: Differential expressions of stromal cell-derived factor-1α and vascular endothelial growth factor in the placental bed of pregnancies complicated by preeclampsia.
abstract: OBJECTIVE
  The aim of this study is to examine the differential expression of stromal cell-derived factor-1α (SDF-1α)/CXCR4 and vascular endothelial growth factor (VEGF) in the third trimester placental bed of normotensive controls and preeclamptic patients.
  
  
  METHODS
  Placental bed tissues were collected from 15 patients with preeclampsia (PE) and 15 gestational-matched normotensive controls at the time of their cesarean delivery. Placental bed expressions of SDF-1α, CXCR4 and VEGF were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR and immunohistochemical staining.
  
  
  RESULTS
  No statistical difference was found between the PE and the normotensive control group with respect to their age and parity, gravidity and body mass index. The placental bed expressions of SDF-1α/CXCR4 and VEGF were significantly decreased in the PE group compared with the normotensive control group.
  
  
  CONCLUSIONS
  This study showed decreased expressions of SDF-1α/CXCR4 and VEGF in the third trimester placental bed of pregnancies with PE. This result suggests that decreased expressions of SDF-1α/CXCR4 and VEGF in the placental bed could be associated with the pathogenesis of PE.
authors.affiliation: Department of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University School of Medicine .
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Kim
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Moon
authors.forename: Dong-Hyung
authors.initials: DH
authors.lastname: Lee
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Park
authors.forename: Bo-Sun
authors.initials: BS
authors.lastname: Joo
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000328:Adult; D054377:Chemokine CXCL12 / Q000378:metabolism*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D019718:Receptors, CXCR4 / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A