title: Chemical constituents from Inonotus obliquus and their biological activities.
abstract: Seven new triterpenes, inonotusol A-G (1-7), one new diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR ((1)H-(1)H COSY, ROESY, HSQC, and HMBC) experiments. In in vitro assays, compounds 6 and 8-16 showed hepatoprotective effects against d-galactosamine-induced WB-F344 cell damage, with inhibitory effects from 34.4% to 81.2%. Compounds 7, 17, and 18 exhibited selective cytotoxicities against KB, Bel-7402, or A-549 cell lines. Compounds 16 and 17 showed inhibitory effects against protein tyrosine kinases, with IC50 values of 24.6 and 7.7 μM, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Cui
authors.initials: C
authors.lastname: Zhao
authors.forename: Hong-Hui
authors.initials: HH
authors.lastname: Pan
authors.forename: Jie
authors.initials: J
authors.lastname: Kang
authors.forename: Xiong-Tao
authors.initials: XT
authors.lastname: Yu
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Wang
authors.forename: Bao-Ming
authors.initials: BM
authors.lastname: Li
authors.forename: Yi-Zhen
authors.initials: YZ
authors.lastname: Xie
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008099:Liver / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D047428:Protein Kinase Inhibitors; D014315:Triterpenes; C587333:inonotusic acid; C587334:inonotusol F; C587335:inonotusol G; D005688:Galactosamine