title: Neutrophil microparticles modulate cytokine production by natural killer cells.
abstract: Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α but enhanced the release of TGF-β1 by IL-2/IL-12-activated NK cells. The inhibitory effect of NMs was strongly attenuated by blockade of phosphatidylserine exposed on NMs. Thus, NMs skew the cytokine profile of NK cells from pro-inflammatory toward anti-inflammatory, potentially favoring the resolution of inflammation.
authors.affiliation: Hematology Research Center, Novy Zykovsky Pr. 4, Moscow 125167, Russia. Electronic address: bpliyev@cardio.ru.
authors.forename: Boris K
authors.initials: BK
authors.lastname: Pliyev
authors.affiliation: Hematology Research Center, Novy Zykovsky Pr. 4, Moscow 125167, Russia.
authors.forename: Mariya V
authors.initials: MV
authors.lastname: Kalintseva
authors.affiliation: Institute of Biomedical Chemistry, Pogodinskaya Str. 10, Moscow 119121, Russia.
authors.forename: Sofya V
authors.initials: SV
authors.lastname: Abdulaeva
authors.affiliation: Institute of Biomedical Chemistry, Pogodinskaya Str. 10, Moscow 119121, Russia.
authors.forename: Konstantin N
authors.initials: KN
authors.lastname: Yarygin
authors.affiliation: Hematology Research Center, Novy Zykovsky Pr. 4, Moscow 125167, Russia.
authors.forename: Valery G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D055252:Cell-Derived Microparticles / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D009504:Neutrophils / Q000166:cytology* / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism
chemical_list: D016207:Cytokines; D010718:Phosphatidylserines
keywords: Cytokines; NK cells; Neutrophil microparticles; Phosphatidylserine