title: Wound healing after mesh inner embedding and outer binding pancreaticojejunostomy in piglets.
abstract: BACKGROUND
  The aim of this study was to introduce a novel technique of pancreaticojejunostomy, namely, mesh inner embedding and outer binding pancreaticojejunostomy, and to evaluate wound healing after this operation in piglets.
  
  
  METHODS
  Thirty-six domestic piglets were randomly divided into 2 groups after pancreaticoduodenectomy: the mesh inner embedding and outer binding pancreaticojejunostomy group (n = 18) and the conventional double-deck invaginated pancreaticojejunostomy group (n = 18). Bursting pressure and breaking strength were assessed on the operative day and on days 7 and 14 postoperatively. The pathologic findings and collagen content of the anastomotic site were evaluated on days 7 and 14 postoperatively.
  
  
  RESULTS
  Both the bursting pressure and breaking strength were significantly higher in the mesh inner embedding and outer binding pancreaticojejunostomy group than in the double-deck invaginated pancreaticojejunostomy group on days 0, 7, and 14 (P < .01). The collagen content of the anastomotic site was significantly higher in the mesh inner embedding and outer binding pancreaticojejunostomy group than in the double-deck invaginated pancreaticojejunostomy group on days 7 and 14 postoperatively (P < .01). The anastomotic site was more completely repaired by connective and granulation tissue in the mesh inner embedding and outer binding pancreaticojejunostomy group on day 7 than in the double-deck invaginated pancreaticojejunostomy group.
  
  
  CONCLUSIONS
  Mesh inner embedding and outer binding pancreaticojejunostomy significantly enhanced the anastomotic firmness and sped up the wound healing process compared with conventional mesh inner embedding and outer binding pancreaticojejunostomy. Therefore, it may decrease the risk of pancreatic fistulas after pancreaticoduodenectomy.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Wanbo
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Dijian
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China steversson@yahoo.com.cn.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D016577:Pancreaticoduodenectomy / Q000379:methods*; D010193:Pancreaticojejunostomy / Q000379:methods*; D011897:Random Allocation; D013526:Surgical Mesh; D013552:Swine; D014945:Wound Healing / Q000502:physiology*
keywords: pancreatic leakage; pancreaticoduodenectomy; pancreaticojejunostomy stomas; pathology