title: [Uric acid and purine plasma levels as plausible markers for placental dysfunction in pre-eclampsia].
abstract: Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.
authors.affiliation: Laboratorio de Fisiología Vascular, Grupo de Investigación en Angiogénesis Tumoral, Departamento de Ciencias Básicas, Universidad del Bío Bío, Chillán, Chile, cescudero@ubiobio.cl.
authors.forename: Carlos
authors.initials: C
authors.lastname: Escudero
authors.affiliation: Servicio de Ginecología y Obstetricia, Hospital Clínico Herminda Martin, Chillán, Chile.
authors.forename: Patricio
authors.initials: P
authors.lastname: Bertoglia
authors.affiliation: Servicio de Ginecología y Obstetricia, Hospital Clínico Herminda Martin, Chillán, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Muñoz
authors.affiliation: Magee Women Research Institute, Departamento de Obstetricia, Ginecología, Epidemiología e Investigación Clínica y Transcripcional, Universidad de Pittsburgh, Pittsburgh, Pensilvania, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D010920:Placenta / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011687:Purines / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D011687:Purines; D014527:Uric Acid; C030985:purine