title: Contribution of particle-size-fractionated airborne lead to blood lead during the National Health and Nutrition Examination Survey, 1999-2008.
abstract: The objective of this work is to examine associations between blood lead (PbB) and air lead (PbA) in particulate matter measured at different size cuts by use of PbB concentrations from the National Health and Nutrition Examination Survey and PbA concentrations from the U.S. Environmental Protection Agency for 1999-2008. Three size fractions of particle-bound PbA (TSP, PM10, and PM2.5) data with different averaging times (current and past 90-day average) were utilized. A multilevel linear mixed effect model was used to characterize the PbB-PbA relationship. At 0.15 μg/m(3), a unit decrease in PbA in PM10 was significantly associated with a decrease in PbB of 0.3-2.2 μg/dL across age groups and averaging times. For PbA in PM2.5 and TSP, slopes were generally positive but not significant. PbB levels were more sensitive to the change in PbA concentrations for children (1-5 and 6-11 years) and older adults (≥ 60 years) than teenagers (12-19 years) and adults (20-59 years). For the years following the phase-out of Pb in gasoline and a resulting upward shift in the PbA particle size distribution, PbA in PM10 was a statistically significant predictor of PbB. The results also suggest that age could affect the PbB-PbA association, with children having higher sensitivity than adults.
authors.affiliation: School of Public Health, Rutgers University , 683 Hoes Lane West, Piscataway, New Jersey 08854, United States.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Meng
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richmond-Bryant
authors.forename: J Allen
authors.initials: JA
authors.lastname: Davis
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cohen
authors.forename: David
authors.initials: D
authors.lastname: Svendsgaard
authors.forename: James S
authors.initials: JS
authors.lastname: Brown
authors.forename: Lauren
authors.initials: L
authors.lastname: Tuttle
authors.forename: Heidi
authors.initials: H
authors.lastname: Hubbard
authors.forename: Joann
authors.initials: J
authors.lastname: Rice
authors.forename: Lisa
authors.initials: L
authors.lastname: Vinikoor-Imler
authors.forename: Jason D
authors.initials: JD
authors.lastname: Sacks
authors.forename: Ellen
authors.initials: E
authors.lastname: Kirrane
authors.forename: Dennis
authors.initials: D
authors.lastname: Kotchmar
authors.forename: Erin
authors.initials: E
authors.lastname: Hines
authors.forename: Mary
authors.initials: M
authors.lastname: Ross
mesh_terms: D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000097:blood*; D005591:Chemical Fractionation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005742:Gasoline; D006801:Humans; D007854:Lead / Q000097:blood* / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D010316:Particle Size; D052638:Particulate Matter / Q000737:chemistry*; D014481:United States; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D005742:Gasoline; D052638:Particulate Matter; D007854:Lead