title: Cytotoxic T cell adoptive immunotherapy as a treatment for nasopharyngeal carcinoma.
abstract: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). We assess the safety and tolerability of adoptive transfer of autologous cytotoxic T lymphocytes (CTLs) specific for the EBV latent membrane protein (LMP) in a patient with recurrent NPC. After infusion, the majority of pulmonary lesions were no longer evident, although the primary tumor did not regress.
authors.affiliation: Australian Centre for Vaccine Development and EBV Biology Laboratory, Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia.
authors.forename: Viviana P
authors.initials: VP
authors.lastname: Lutzky
authors.forename: Pauline
authors.initials: P
authors.lastname: Crooks
authors.forename: Leanne
authors.initials: L
authors.lastname: Morrison
authors.forename: Natasha
authors.initials: N
authors.lastname: Stevens
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Davis
authors.forename: Monika
authors.initials: M
authors.lastname: Corban
authors.forename: David
authors.initials: D
authors.lastname: Hall
authors.forename: Benedict
authors.initials: B
authors.lastname: Panizza
authors.forename: William B
authors.initials: WB
authors.lastname: Coman
authors.forename: Scott
authors.initials: S
authors.lastname: Coman
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Moss
mesh_terms: D000328:Adult; D002277:Carcinoma; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000517:prevention & control; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000009:adverse effects* / Q000379:methods*; D008168:Lung / Q000473:pathology; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D055502:Secondary Prevention; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome; D014763:Viral Matrix Proteins / Q000276:immunology
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins