title: Computed tomographic findings of radiation-induced acute adrenal injury with associated radiation nephropathy: a case report.
abstract: Radiation nephropathy was first recognized in 1906. The kidney is a radiosensitive organ with a tolerance dose (5% complications in 5 years) of 20 Gray. The imaging findings of acute and chronic radiation induced renal injury are previously described. Radiation-induced adrenal injury, to our knowledge, has not been described in the literature. Unlike the kidneys and other upper abdominal organs, the adrenal glands are traditionally thought to be radio-resistant, protected from radiation-induced injury by proximity to adjacent organs and by the adrenal medulla which reportedly has increased radio-resistance. We present the computed tomographic imaging findings of a patient with acute radiation induced adrenal injury which resulted in adrenal insufficiency following radiotherapy of an adjacent thecal metastasis.
authors.affiliation: The Ottawa Hospital, The University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Nicola
authors.initials: N
authors.lastname: Schieda
authors.affiliation: The Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, Philadelphia, PA, USA.
authors.forename: Parvati
authors.initials: P
authors.lastname: Ramchandani
authors.affiliation: The Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, Philadelphia, PA, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Siegelman
keywords: Radiation; adrenal glands; computed tomography; kidneys; nephropathy; radiotherapy