title: Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition.
abstract: Hepatocyte growth factor (HGF) is an angiogenic, cardioprotective factor important for tissue and vascular repair. High levels of HGF are associated with chronic inflammatory diseases, such as coronary artery disease (CAD) and periodontitis, and are suggested as a marker of the ongoing atherosclerotic event in patients with CAD. Periodontal disease is more prevalent among patients with CAD than among healthy people. Recent studies indicate a reduced biological activity of HGF in different chronic inflammatory conditions. Biologically active HGF has high affinity to heparan sulfate proteoglycan (HSPG) on cell-membrane and extracellular matrix. The aim of the study was to investigate the serum concentration and the biological activity of HGF with ELISA and surface plasmon resonance (SPR), respectively, before and at various time points after percutaneous coronary intervention (PCI) in patients with CAD, and to examine the relationship with periodontal condition. The periodontal status of the CAD patients was examined, and the presence of P. gingivalis in periodontal pockets was analyzed with PCR. The HGF concentration was significantly higher, at all time-points, in patients with CAD compared to the age-matched controls (P< 0.001), but was independent of periodontal status. The HGF concentration and the affinity to HSPG adversely fluctuated over time, and the biological activity increased one month after intervention in patients without periodontitis. We conclude that elevated concentration of HGF but with reduced biological activity might indicate a chronic inflammatory profile in patients with CAD and periodontitis.
authors.affiliation: Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden ; PEAS Institute, Linköping, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Lönn
authors.affiliation: Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Starkhammar Johansson
authors.affiliation: Division of Clinical Pathology and Clinical Genetics, Linköping University, Faculty of Health Sciences, Linköping, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Kälvegren
authors.affiliation: Department of Medical and Health Sciences, University Hospital, Linköping, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Brudin
authors.affiliation: Department of Medical and Health and Sciences, Division of Drug Research, Faculty of Health Sciences, Linköping University, Linköping, Sweden ; Department of Physics, Chemistry and Biology, Division of Molecular Physics and Nanoscience, Linköping University, Linköping, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Skoglund
authors.affiliation: Division of Community Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Garvin
authors.affiliation: Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden ; Department of Cardiology, Örebro University Hospital, SE-701 85 Örebro, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Särndahl
authors.affiliation: Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Ravald
authors.affiliation: Department of Cardiology, Heart Center, Linköping University Hospital, Linköping, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Richter
authors.affiliation: Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Bengtsson
authors.affiliation: PEAS Institute, Linköping, Sweden ; Department of Molecular and Clinical Medicine, Division of Infectious Diseases, University Hospital, Linköping, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Nayeri
keywords: Angiography; Coronary artery disease; Hepatocyte growth factor; Periodontal disease; Porphyromonas gingivalis