title: A potential role for GPR55 in the regulation of energy homeostasis.
abstract: G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this, the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Simcocks
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
authors.forename: Lannie
authors.initials: L
authors.lastname: O'Keefe
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
authors.forename: Kayte A
authors.initials: KA
authors.lastname: Jenkin
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne 8001, VIC, Australia; The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Mathai
authors.affiliation: Department of Physiology, The University of Melbourne, Melbourne 3010, VIC, Australia.
authors.forename: Deanne H
authors.initials: DH
authors.lastname: Hryciw
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne 8001, VIC, Australia. Electronic address: andrew.mcainch@vu.edu.au.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McAinch
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled