title: Nicotine increases cerebellar activity during finger tapping.
abstract: Nicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen healthy subjects while they performed an auditory-paced finger tapping task. Subjects performed the task, after receiving either a nicotine patch or placebo treatment, in a single blind, crossover design. Compared to placebo, nicotine treatment increased response in the cerebellar vermis. Increased vermal activity, in the absence of changes in other task-related regions suggests specificity in nicotine's effects.
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
authors.forename: Korey P
authors.initials: KP
authors.lastname: Wylie
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
authors.forename: Jody
authors.initials: J
authors.lastname: Tanabe
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
authors.forename: Laura F
authors.initials: LF
authors.lastname: Martin
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
authors.forename: Narin
authors.initials: N
authors.lastname: Wongngamnit
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; Research Service, Denver Veterans Affairs Medical Center, Research Service (151), Eastern Colorado Health System, Denver, Colorado, United States of America.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Tregellas
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology*; D018592:Cross-Over Studies; D005260:Female; D005385:Fingers / Q000502:physiology*; D007839:Functional Laterality; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time
chemical_list: D009538:Nicotine