title: [Diagnosis and therapy of atherosclerosis through molecular biological approaches possibility of HDL-targeting therapy by manipulation of micro RNA-33].
abstract: Elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of coronary heart disease (CHD), and statin therapy to decrease LDL-C significantly reduces the risk of cardiovascular events. Despite the effectiveness of statin therapy, there remains a significant residual cardiovascular risk. A low plasma concentration of high-density lipoprotein cholesterol (HDL-C) is associated with an increased risk of CHD. However, recent clinical trials aimed at reducing the CHD risk by raising HDL-C levels have not shown satisfactory results, and it is becoming evident that a functional HDL-C is a more desirable target than simply elevating its level. This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs.
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan. kohono@kuhp.kyoto-u.ac.jp
authors.forename: Koh
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000628:therapy*; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D035683:MicroRNAs / Q000627:therapeutic use*; D057089:Pathology, Molecular / Q000379:methods; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D035683:MicroRNAs