title: [Rational and irrational of azithromycin use].
abstract: Azithromycin (AZM) has unique pharmacokinetic and pharmacodynamic characteristics that give it unusual clinical properties for an antibiotic. Gradually, potential indications have increased reaching a number of clinical situations, including pulmonary prophylaxis such as cystic fibrosis or bronchiectasis or chronic obstructive pulmonary diseases. However, the risks associated with its use are particularly concerning by selecting power that make AZM as real ecological time bomb. This should lead to only use AZM in situations where well-conducted clinical studies have demonstrated an indisputable superiority over standard treatment or placebo, and by limiting the number of patients treated.
authors.affiliation: Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie; Service de néonatalogie, hôpital intercommunal de Créteil, 40 avenue de Verdun, 94010 Créteil Cedex, France; Association clinique et thérapeutique infantile du Val-de-Marne (ACTIV), 27 rue Inkermann, 94100 Saint-Maur-des-Faussés, France. Electronic address: Robert.Cohen@wanadoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie; Service de pédiatrie générale, hôpital Armand-Trousseau, 26 avenue du Docteur-Arnold-Netter, 75571 Paris Cedex 12, France; Université Pierre-et-Marie-Curie Paris 6, 4 place Jussieu, 75005 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Grimprel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D004363:Drug Utilization / Q000592:standards; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin