title: Utilizing combinatorial chemistry and rational design: peptidic tweezers with nanomolar affinity to DNA can be transformed into efficient vectors for gene delivery by addition of a lipophilic tail.
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen (Germany); Current address: Stanford University, Department of Chemistry, Stauffer I, Stanford, CA 94305 (USA).
authors.forename: Hannes Y
authors.initials: HY
authors.lastname: Kuchelmeister
authors.forename: Sarah
authors.initials: S
authors.lastname: Karczewski
authors.forename: Aljona
authors.initials: A
authors.lastname: Gutschmidt
authors.forename: Shirley
authors.initials: S
authors.lastname: Knauer
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000235:genetics*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D015394:Molecular Structure; D014162:Transfection
chemical_list: D004247:DNA
keywords: DNA binding; DNA transfection; DNA vectors; combinatorial chemistry; peptide tweezers