title: [Diffuse infantile hepatic hemangioendothelioma: a case report].
abstract: Infantile hepatic hemangioendothelioma (IHHE) is the most common benign hepatic tumor in children (12% of hepatic tumors), that usually responds well to therapy and has low mortality rates. In extremely rare cases of diffuse tumors resistant to therapy, size and blood flow can lead to cardiorespiratory failure and death. A 3-month-old male infant presented with respiratory infections and an abdominal mass, with frequent broncho-obstructive attacks. The CT, MRI and DSA exams showed typical morphology of hemangiendothelioma that was proven on histopathological biopsy. The tumor was resistant to standard medical therapy, and its volume led to cardiopulmonary arrest and death at 13 months of age. In rare cases of diffuse therapy-resistant IHHE a liver transplantation should be considered as an earlier treatment.
authors.affiliation: Klinicki zavod za dijagnosticku i intervencijsku radiologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb. ivica.sjekavica@zg.htnet.hr
authors.forename: Ivica
authors.initials: I
authors.lastname: Sjekavica
authors.affiliation: Klinicki zavod za dijagnosticku i intervencijsku radiologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Marko
authors.initials: M
authors.lastname: Petrovecki
authors.affiliation: Klinicki zavod za dijagnosticku i intervencijsku radiologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Vice
authors.initials: V
authors.lastname: Sunjara
authors.affiliation: Zavod za pedijatrijsku hematoonkologiju, Klinika za pedijatriju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Maja
authors.initials: M
authors.lastname: Pavlović
authors.affiliation: Klinicki zavod za dijagnosticku i intervencijsku radiologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Ranka Stern
authors.initials: RS
authors.lastname: Padovan
mesh_terms: D017809:Fatal Outcome; D006323:Heart Arrest / Q000209:etiology; D006390:Hemangioendothelioma / Q000150:complications / Q000473:pathology / Q000628:therapy; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy; D008297:Male; D047368:Tumor Burden