title: Synthesis and biological evaluation of paleo-soraphens.
abstract: Synthesis can provide molecules such as paleo-soraphens A and B that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.
authors.affiliation: Institut für Organische Chemie und Biomolekulares, Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover (Germany); Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, Braunschweig (Germany).
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Lu
authors.forename: Aruna
authors.initials: A
authors.lastname: Raja
authors.forename: Raimo
authors.initials: R
authors.lastname: Franke
authors.forename: Dirk
authors.initials: D
authors.lastname: Landsberg
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
mesh_terms: D000595:Amino Acid Sequence; D001688:Biological Products; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D061065:Polyketides / Q000737:chemistry
chemical_list: D001688:Biological Products; D018942:Macrolides; D061065:Polyketides; C086151:soraphen A
keywords: acetyl-CoA carboxylase; antitumor agents; evolution; paleo-soraphens; polyketides