title: Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation.
authors.affiliation: Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
authors.forename: Nelly
authors.initials: N
authors.lastname: Siller
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Egerer
authors.forename: Johanna
authors.initials: J
authors.lastname: Weiss
authors.forename: Gerd
authors.initials: G
authors.lastname: Mikus
mesh_terms: D000368:Aged; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008140:Lorazepam / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006993:Hypnotics and Sedatives; C491474:UGT2B7 protein, human; D014453:Glucuronosyltransferase; C486404:UGT2B4 protein, human; D008140:Lorazepam