title: Value of monoenergetic low-kV dual energy CT datasets for improved image quality of CT pulmonary angiography.
abstract: OBJECTIVE
  High vessel attenuation and high contrast-to-noise ratio (CNR) are prerequisites for high diagnostic confidence in CT pulmonary angiography (CTPA). This study evaluated the impact of calculated monoenergetic dual-energy (DE) CTPA datasets on vessel attenuation and CNR.
  
  
  METHODS
  50 Patients (24 men, mean age 68 ± 14 years) who underwent DE-CTPA were retrospectively included in this study. The 80 and 140-kV DE polyenergetic image data were used to calculate virtual monoenergetic image datasets in 10 kiloelectron volt (keV) increments from 40 to 120 keV. Vessel and soft tissue attenuation and image noise were measured in various regions of interest and the CNR was subsequently calculated. Differences in vessel attenuation and CNR were compared between the different monoenergetic datasets. The best monoenergetic dataset was then compared to the standard 120-kV polyenergetic dataset.
  
  
  RESULTS
  Vessel attenuation and CNR of 70-keV CTPA datasets were superior to all other monoenergetic image datasets (all p<0.05). 70-keV monoenergetic datasets provided a statistically significant 12% increase in mean vessel attenuation compared to standard 120-kV polyenergetic datasets (384 ± 117 HU vs. 342 ± 106 HU, respectively; p<0.0001) and a statistically significant 18% increase in mean CNR (29 ± 13 vs. 24 ± 11 respectively; p<0.0001).
  
  
  CONCLUSIONS
  Virtual 70-keV monoenergetic CTPA image datasets significantly increase vessel attenuation and CNR of DE-CTPA studies, suggesting that clinical application of low-keV monoenergetic reconstructions may allow a decrease in the amount of iodinated contrast required for adequate image quality in DE-CTPA examinations.
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: Paul.Apfaltrer@medma.uni-heidelberg.de.
authors.forename: Paul
authors.initials: P
authors.lastname: Apfaltrer
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Sudarski
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Schneider
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Nance
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Haubenreisser
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: CT-angiography; Dual-energy CT; Dual-source CT; Monoenergetic imaging; Pulmonary embolism