title: [Use of rebiopsy for clinically diagnosed metastatic lesion in patients with breast cancer].
abstract: OBJECTIVE
  To evaluate the roles of rebiopsy for clinically diagnosed metastatic lesion in detecting the changes of hormonal receptors and second malignancy.
  
  
  METHODS
  The metastatic lesions were rebiopsied by core needle aspiration or incision in 42 patients with a clinical diagnosis of metastatic breast cancer by computed tomography or ultrasound.
  
  
  RESULTS
  None of major complications occurred. Thirty-one metastases were proved pathologically. The discrepancies between primary breast cancer and metastatic lesions of estrogen receptor(ER), progesterone receptor(PR), HER-2 statuses were 22.6%, 25.8% and 9.7% respectively. And 7 second malignancies were found (16.7%, 5 primary lung and 2 primary pancreas cancers). Four patients showed no relapse through rebiopsy.
  
  
  CONCLUSIONS
  The rebiopsy of clinically diagnosed metastatic breast cancer may find the discrepancies of ER, PR, HER-2 statuses and second malignancy so as to change the therapeutic strategies of patients.
authors.affiliation: Department of Oncology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Qu
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.forename: Xiao-song
authors.initials: XS
authors.lastname: Chen
authors.forename: Ruo-bing
authors.initials: RB
authors.lastname: Ren
authors.forename: Rong
authors.initials: R
authors.lastname: Cai
authors.forename: Gu-yin
authors.initials: GY
authors.lastname: Lou
authors.affiliation: Comprehensive Breast Health Center, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025. Email: kwshen@medmail.com.cn.
authors.forename: Kun-wei
authors.initials: KW
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human