title: [Cortical spreading depolarization phenomena in patients with traumatic and ischemic brain injuries. Results of a pilot study].
abstract: OBJECTIVE
  To determine the frequency and duration of cortical spreading depolarization (CSD) and CSD-like episodes in patients with traumatic brain injury (TBI) and malignant middle cerebral artery infarction (MMCAI) requiring craniotomy.
  
  
  METHODS
  A descriptive observational study was carried out during 19 months.
  
  
  METHODS
  Neurocritical patients.
  
  
  METHODS
  Sixteen patients were included: 9 with MMCAI and 7 with moderate or severe TBI, requiring surgical treatment.
  
  
  METHODS
  A 6-electrode subdural electrocorticographic (ECoG) strip was placed onto the perilesional cortex.
  
  
  METHODS
  An analysis was made of the time profile and the number and duration of CSD and CSD-like episodes recorded from the ECoGs.
  
  
  RESULTS
  Of the 16 patients enrolled, 9 presented episodes of CSD or CSD-like phenomena, of highly variable frequency and duration.
  
  
  CONCLUSIONS
  Episodes of CSD and CSD-like phenomena are frequently detected in the ischemic penumbra and/or traumatic cortical regions of patients with MMCAI who require decompressive craniectomy or of patients with contusional TBI.
authors.affiliation: Servicio de Neurofisiología, Hospital Universitario Vall d'Hebron, Barcelona, España; Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Sueiras
authors.affiliation: Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España; Servicio de Neurocirugía, Hospital Universitario Vall d'Hebron, Barcelona, España. Electronic address: sahuquillo@neurotrauma.net.
authors.forename: J
authors.initials: J
authors.lastname: Sahuquillo
authors.affiliation: Servicio de Neurofisiología, Hospital Universitario Vall d'Hebron, Barcelona, España.
authors.forename: B
authors.initials: B
authors.lastname: García-López
authors.affiliation: Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Á
authors.initials: Á
authors.lastname: Sánchez-Guerrero
authors.affiliation: Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España; Servicio de Neurocirugía, Hospital Universitario Vall d'Hebron, Barcelona, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Poca
authors.affiliation: Servicio de Neurología, Hospital Universitario Vall d'Hebron, Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Santamarina
authors.affiliation: Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España; Unidad de Cuidados Intensivos de Neurotraumatología, Hospital Universitario Vall d'Hebron, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Riveiro
authors.affiliation: Department of Clinical Neurophysiology, Glostrup Hospital, Copenhagen, Dinamarca.
authors.forename: M
authors.initials: M
authors.lastname: Fabricius
authors.affiliation: Department of Neurosurgery, King's College, London, Reino Unido.
authors.forename: A J
authors.initials: AJ
authors.lastname: Strong
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology*; D013181:Cortical Spreading Depression; D000069280:Electrocorticography; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
keywords: Brain metabolism; Brain tissue oxygen pressure; Cortical spreading depolarization; Despolarización propagada; Electrocorticografía; Electrocorticography; Infarto maligno de la arteria cerebral media; Malignant middle cerebral artery infarction; Metabolismo cerebral; Microdialysis; Microdiálisis; Presión tisular de oxígeno; Traumatic brain injury; Traumatismo craneoencefálico