title: HLA frequencies and associations in cystic fibrosis.
abstract: Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.
authors.affiliation: Department of Paediatrics & Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre, Maastricht, the Netherlands.
authors.forename: M P M
authors.initials: MP
authors.lastname: Adriaanse
authors.forename: A C E
authors.initials: AC
authors.lastname: Vreugdenhil
authors.forename: M
authors.initials: M
authors.lastname: Groeneweg
authors.forename: H T
authors.initials: HT
authors.lastname: Brüggenwirth
authors.forename: S J A M
authors.initials: SJ
authors.lastname: Castelijns
authors.forename: C K
authors.initials: CK
authors.lastname: van der Ent
authors.forename: C E M
authors.initials: CE
authors.lastname: Voorter
authors.forename: M G J
authors.initials: MG
authors.lastname: Tilanus
mesh_terms: D003550:Cystic Fibrosis / Q000235:genetics* / Q000276:immunology*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: HLA antigens; HLA-DQ alpha-chains; HLA-DQ beta-chains; HLA-DRB1 chains; cystic fibrosis; cystic fibrosis transmembrane conductance regulator