title: Challenges and opportunities for respiratory syncytial virus vaccines.
abstract: Respiratory syncytial virus (RSV) causes a significant proportion of the global burden of respiratory disease. Here we summarize the conclusions of a series of chapters written by investigators describing and interpreting what is known about the virology, clinical manifestations, immunity, pathogenesis, and epidemiology of RSV relevant to vaccine development. Several technological and conceptual advances have recently occurred that make RSV vaccine development more feasible, and this collected knowledge is intended to help inform and organize the future contributions of funding agencies, scientists, regulatory agencies, and policy makers that will be needed to achieve the goal of a safe, effective, and accessible vaccine to prevent RSV-associated disease.
authors.affiliation: Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA, bgraham@nih.gov.
authors.forename: Barney S
authors.initials: BS
authors.lastname: Graham
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Anderson
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects; D000368:Aged; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005822:Genetic Vectors / Q000276:immunology; D058507:Host Specificity; D006801:Humans; D007223:Infant; D016365:Liability, Legal; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit
chemical_list: D022261:Respiratory Syncytial Virus Vaccines; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit