title: A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data.
abstract: There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy.
authors.affiliation: The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address: Helen.mcshane@ndm.ox.ac.uk.
authors.forename: Helen
authors.initials: H
authors.lastname: McShane
authors.affiliation: Public Health England, Porton Down, Porton, Salisbury, UK. Electronic address: ann.rawkins@phe.gov.uk.
authors.forename: Ann
authors.initials: A
authors.lastname: Williams
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D002417:Cattle; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D017410:Practice Guidelines as Topic; D011323:Primates; D014376:Tuberculosis / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000494:pharmacology*; D019444:Vaccines, DNA
chemical_list: D001500:BCG Vaccine; C549320:MVA 85A; D032581:Tuberculosis Vaccines; D019444:Vaccines, DNA
keywords: Clinical; Efficacy; MVA85A; Pre-clinical; Vaccine