title: Recruitment update of AHEAD.
abstract: The multicenter prospective non-interventional AHEAD study was initiated to obtain long-term outcome data on joint health, HR-QoL, haemophilia-related co-morbidities, and the effectiveness and safety of ADVATE (recombinant anti-hemophilic factor VIII, plasma-free method [octocog alfa]) in routine clinical practice. The German AHEAD study arm aims to enroll up to 500 patients in up to 35 haemophilia treatment centers (HTCs); patient recruitment started in June 2010. The study arm conducted in other European countries is expected to enroll 350 patients from more than 50 HTCs; recruitment started in June 2011. In both study arms, recruitment will continue through the end of 2015, and each enrolled patient will be followed for a total of four years.
authors.forename: J
authors.initials: J
authors.lastname: Oldenburg
authors.forename: R
authors.initials: R
authors.lastname: Zimmermann
authors.forename: A
authors.initials: A
authors.lastname: Huth-Kühne
authors.forename: K
authors.initials: K
authors.lastname: Kurnik
authors.forename: R
authors.initials: R
authors.lastname: Klamroth
authors.forename: I
authors.initials: I
authors.lastname: Abraham
authors.forename: H
authors.initials: H
authors.lastname: Brondke
authors.forename: M
authors.initials: M
authors.lastname: Pirck
authors.forename: W
authors.initials: W
authors.lastname: Engl
authors.forename: A
authors.initials: A
authors.lastname: Reininger
authors.forename: G
authors.initials: G
authors.lastname: Spotts
mesh_terms: D015897:Comorbidity; D005060:Europe / Q000453:epidemiology; D005169:Factor VIII / Q000627:therapeutic use*; D005858:Germany / Q000453:epidemiology; D006467:Hemophilia A / Q000188:drug therapy* / Q000401:mortality*; D006470:Hemorrhage / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007592:Joint Diseases / Q000401:mortality* / Q000517:prevention & control*; D018579:Patient Selection; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D005169:Factor VIII