title: South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin.
authors.affiliation: Division of Dermatology, University of Cape Town, Cape Town, South Africa.
authors.forename: Fatemah
authors.initials: F
authors.lastname: Thawer-Esmail
authors.affiliation: Faculty of Food Technology and Biotechnology, Department of Chemistry and Biochemistry, Laboratory for Analytical Chemistry, University of Zagreb, Zagreb, Croatia.
authors.forename: Ivone
authors.initials: I
authors.lastname: Jakasa
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Gail
authors.initials: G
authors.lastname: Todd
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Yaran
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Brown
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Karin
authors.initials: K
authors.lastname: Kroboth
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Linda E
authors.initials: LE
authors.lastname: Campbell
authors.affiliation: Department of Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
authors.forename: Grainne M
authors.initials: GM
authors.lastname: O'Regan
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: W H Irwin
authors.initials: WH
authors.lastname: McLean
authors.affiliation: Department of Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Department of Clinical Medicine, Trinity College, Dublin, Ireland. Electronic address: irvinea@tcd.ie.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
authors.affiliation: Coronel Institute of Occupational Health, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Sanja
authors.initials: S
authors.lastname: Kezic
authors.affiliation: Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, United Kingdom.
authors.forename: Aileen
authors.initials: A
authors.lastname: Sandilands
mesh_terms: D000293:Adolescent; D000328:Adult; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D000091344:Filaggrin Proteins; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007381:Intermediate Filament Proteins / Q000737:chemistry / Q000235:genetics*; D008297:Male; D020125:Mutation, Missense / Q000235:genetics; D011110:Polymorphism, Genetic; D059748:Proteolysis; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism; D012306:Risk; D013019:South Africa; D014560:Urocanic Acid / Q000737:chemistry / Q000378:metabolism; D055815:Young Adult
chemical_list: D002264:Carboxylic Acids; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D011760:Pyrrolidinones; D014560:Urocanic Acid