title: Ligands of the neuropeptide Y Y2 receptor.
abstract: Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2, Y4 and Y5. Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders, alcohol and drugs of abuse, epilepsy, pain, and cancer. The lack of small molecule non-peptidic Y2 receptor modulators suitable as in vivo pharmacological tools hampered the progress to uncover the precise pharmacological role of Y2. Only in recent years, several potent, selective and non-peptidic Y2 antagonists have been discovered providing the tools to validate Y2 receptor as a therapeutic target. This Letter reviews Y2 receptor modulators mainly non-peptidic antagonists and their structure-activity relationships.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Gopi Kumar
authors.initials: GK
authors.lastname: Mittapalli
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: eroberts@scripps.edu.
authors.forename: Edward
authors.initials: E
authors.lastname: Roberts
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D006801:Humans; D008024:Ligands; D009478:Neuropeptide Y / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D017476:Receptors, Neuropeptide Y / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000178:Acrylamides; D008024:Ligands; C483241:N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-(1-(2-cyclopentyl-ethyl)-piperidin-4yl)acrylamide; D009478:Neuropeptide Y; D010880:Piperidines; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor
keywords: Agonists; Antagonists; Brain-penetration; Neuropeptide Y; Non-peptidic; Structure–activity relationships; Y2 receptor