title: Autophagy chews Fap to promote apoptosis.
abstract: Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
authors.forename: Sanket
authors.initials: S
authors.lastname: Joshi
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Ryan
mesh_terms: D001343:Autophagy; D019070:Cell Lineage; D006801:Humans; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13 / Q000378:metabolism*; D059748:Proteolysis
chemical_list: C516742:PTPN13 protein, human; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13