title: (+)-rumphiin and polyalthurea, new compounds from the stems of Polyalthia rumphii.
abstract: Two new compounds, (+)-rumphiin (3) and polyalthurea (7), together with seven known ones, 3,4,5-trimethoxy benzoic acid (1), (-)-seselinone (2), cannabisin D (4), allantoin (5), oxostephanine (6) and a mixture of beta-sitosterol (8) and stigmasterol (9) were isolated from the stems of Polyalthia rumphii. The chemical structures of 3 and 7 were elucidated by the combination of spectroscopic data, and the absolute configuration of 3 at C-2 was determined by the matrix method to be R. All compounds were evaluated for their cytotoxicity on four human cancer cell lines, which demonstrated that 3 was a moderate bioactive lignan, and 6 showed significant anticancer activity against SPC-A-1 and BEL-7402 cell lines with IC50 values of 1.47 and 1.73 microg/mL, respectively.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Haikou 571158, China.
authors.forename: Tian-Shan
authors.initials: TS
authors.lastname: Wang
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Luo
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Meng-Xiong
authors.initials: MX
authors.lastname: He
authors.forename: Ming-Guo
authors.initials: MG
authors.lastname: Zhong
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
mesh_terms: D000481:Allantoin / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020014:K562 Cells; D017705:Lignans / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry; D031044:Polyalthia / Q000737:chemistry*; D012855:Sitosterols / Q000302:isolation & purification; D013265:Stigmasterol / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D012855:Sitosterols; C523277:seselinone; D000481:Allantoin; C025473:gamma-sitosterol; D005707:Gallic Acid; D013265:Stigmasterol; C005854:3,4,5-trimethoxybenzoic acid