title: Linking GATA-3 and interleukin-13: implications in asthma.
abstract: BACKGROUND
  Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma.
  
  
  METHODS
  The role of Th2 cells in the pathogenesis of the asthma is primarily mediated through the cytokine IL-13, also produced by type 2 innate lymphoid cells, that comes under the transcriptional regulation of GATA3. In this review we will try to explore the link between IL-13 and GATA3 in the progression and regulation of asthma and its possible role as a therapeutic target.
  
  
  CONCLUSIONS
  Inhibition of GATA3 activity or blockade of GATA3 expression may attenuate the interleukin-13 mediated asthma phenotypes. So, GATA3 might be a potential therapeutic target for the treatment of allergic asthma.
authors.affiliation: Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Jammu, India.
authors.forename: Sheikh
authors.initials: S
authors.lastname: Rayees
authors.forename: Fayaz
authors.initials: F
authors.lastname: Malik
authors.forename: Syed Imran
authors.initials: SI
authors.lastname: Bukhari
authors.forename: Gurdarshan
authors.initials: G
authors.lastname: Singh
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D002454:Cell Differentiation; D050990:GATA3 Transcription Factor / Q000276:immunology*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics / Q000276:immunology*; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology
chemical_list: D050990:GATA3 Transcription Factor; D018793:Interleukin-13