title: Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke.
abstract: Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.
authors.affiliation: Department of Emergency Medicine, Medical Faculty, Yuzuncu Yıl University, Van, Turkey, sevdegulkaradas@gmail.com.
authors.forename: Sevdegul
authors.initials: S
authors.lastname: Karadas
authors.forename: Refah
authors.initials: R
authors.lastname: Sayın
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Hayriye
authors.initials: H
authors.lastname: Gonullu
authors.forename: Celal
authors.initials: C
authors.lastname: Katı
authors.forename: Recep
authors.initials: R
authors.lastname: Dursun
authors.forename: Latif
authors.initials: L
authors.lastname: Duran
authors.forename: Edip
authors.initials: E
authors.lastname: Gonullu
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications*; D008297:Male; D019216:Metals, Heavy / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000097:blood* / Q000209:etiology*; D014131:Trace Elements / Q000097:blood*
chemical_list: D019216:Metals, Heavy; D014131:Trace Elements