title: Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras.
abstract: OBJECTIVE
  Estimation of left ventricular ejection fraction (LVEF) with equilibrium 99MTc-HSA equilibrium radionuclide angiography (MUGA) is frequently used for assessing cardiac function. The purpose of this study was to compare intra- and interobserver variation between three different gamma cameras.
  
  
  METHODS
  Eighty-two patients, scanned in the same sequential order on the three cameras. Each acquisition was analyzed twice by two technologists. Inter- and intraobserver variations were calculated as the coefficient of variation and the 95% confidence interval for limits of agreement between each sequence of analyses for each of the three cameras.
  
  
  RESULTS
  The lowest intraobserver variations in LVEF for the two NaI-detector cameras were 3.1% (-4.0% to 3.5%) for the planar and 3.4% (-4.2% to 4.5%) for SPECT (P ≤ 0.001-0.019), the highest result for the CZT SPECT camera was 2.6% (-2.9% to 3.1%). Similarly, interobserver variation was 4.8% (-4.8% to 6.4%) and 4.9% (-5.4% to 7.5%), respectively, for each of the NaI-detector cameras and 3.3% (-3.4% to 4.3%) for the CZT SPECT camera (P ≤ 0.001-0.008).
  
  
  CONCLUSIONS
  The CZT detector camera was superior to both NaI detector cameras regarding intra- and interobserver variation. The CZT SPECT camera may identify changes in LVEF with greater certainty than its NaI detector-equipped counterparts.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Herlev, Herstedvesterstræde 54, 2620, Albertslund, Denmark, mariamaj1@hotmail.com.
authors.forename: Maria Maj
authors.initials: MM
authors.lastname: Jensen
authors.forename: Ulla
authors.initials: U
authors.lastname: Schmidt
authors.forename: Chenxi
authors.initials: C
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Zerahn
mesh_terms: D019187:Cadmium Compounds / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D015902:Gamma Cameras; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013691:Tellurium / Q000528:radiation effects; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D015032:Zinc / Q000528:radiation effects
chemical_list: D019187:Cadmium Compounds; D015032:Zinc; D013691:Tellurium; C028337:cadmium telluride