title: (+)-Catechin attenuates activation of hepatic stellate cells.
abstract: (+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.
authors.affiliation: Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Cristina Machado
authors.initials: CM
authors.lastname: Bragança de Moraes
authors.forename: Shanna
authors.initials: S
authors.lastname: Bitencourt
authors.forename: Fernanda Cristina
authors.initials: FC
authors.lastname: de Mesquita
authors.forename: Denizar
authors.initials: D
authors.lastname: Mello
authors.forename: Leticia Paranhos
authors.initials: LP
authors.lastname: de Oliveira
authors.forename: Gabriela Viegas
authors.initials: GV
authors.lastname: da Silva
authors.forename: Vinicius
authors.initials: V
authors.lastname: Lorini
authors.forename: Eduardo
authors.initials: E
authors.lastname: Caberlon
authors.forename: Bruno
authors.initials: B
authors.lastname: de Souza Basso
authors.forename: Julia
authors.initials: J
authors.lastname: Schmid
authors.forename: Gabriela Acevedo
authors.initials: GA
authors.lastname: Ferreira
authors.forename: Jarbas Rodrigues
authors.initials: JR
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D002460:Cell Line; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000187:drug effects*; D016753:Interleukin-10 / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis; D051379:Mice; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013237:Stereoisomerism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D024042:Collagen Type I; D016207:Cytokines; D008055:Lipids; D047495:PPAR gamma; D012333:RNA, Messenger; D016753:Interleukin-10; D002392:Catechin
keywords: catechin; hepatic stellate cell; inflammation; liver fibrosis; peroxisome proliferator-activated receptor γ; type I collagen