title: Bacterial toxins and small molecules elucidate endosomal trafficking.
abstract: Bacterial toxins and small molecules are useful tools for studying eukaryotic cell biology. In a recent issue of PNAS, Gillespie and colleagues describe a novel small molecule inhibitor of bacterial toxins and virus trafficking through the endocytic pathway, 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone (EGA), that prevents transport from early to late endosomes.
authors.affiliation: MedImmune, Granta Park, Cambridge, UK.
authors.forename: Louise H
authors.initials: LH
authors.lastname: Slater
authors.affiliation: Infectious Disease Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Clatworthy
authors.affiliation: Infectious Disease Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. Electronic address: dhung@broadinstitute.org.
authors.forename: Deborah T
authors.initials: DT
authors.lastname: Hung
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D011992:Endosomes / Q000187:drug effects*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D012664:Semicarbazones / Q000494:pharmacology*; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D001427:Bacterial Toxins; D012664:Semicarbazones