title: Small bowel transglutaminase 2-specific IgA deposits in dermatitis herpetiformis.
abstract: Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. Untreated coeliac disease patients are known to have transglutaminase 2 (TG2)-targeted IgA deposits in the small bowel mucosa. To evaluate whether similar intestinal IgA deposits are also present in DH and whether the deposits disappear with gluten-free diet, 47 untreated and 27 treated DH patients were studied. Seventy-nine percent of untreated and 41% of the treated DH patients had TG2-specific IgA deposits in the small bowel, and the presence of the deposits showed a significant association with the degree of small bowel villous atrophy (p < 0.001). Other coeliac-disease related inflammatory markers were also investigated, and the density of small bowel mucosal intraepithelial γδ(+) T cells was increased in 91% of untreated and 73% of treated DH patients. The results show that the majority of untreated DH patients have similar gluten-dependent TG2-specific IgA deposits the small bowel mucosa as coeliac disease patients.
authors.affiliation: Department of Dermatology, Tampere University Hospital, FIN-33521 Tampere, Finland. teea.salmi@uta.fi.
authors.forename: Teea T
authors.initials: TT
authors.lastname: Salmi
authors.forename: Kaisa
authors.initials: K
authors.lastname: Hervonen
authors.forename: Kaija
authors.initials: K
authors.lastname: Laurila
authors.forename: Pekka
authors.initials: P
authors.lastname: Collin
authors.forename: Markku
authors.initials: M
authors.lastname: Mäki
authors.forename: Outi
authors.initials: O
authors.lastname: Koskinen
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Katri
authors.initials: K
authors.lastname: Kaukinen
authors.forename: Timo
authors.initials: T
authors.lastname: Reunala
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D001323:Autoantibodies / Q000032:analysis*; D015551:Autoimmunity; D015415:Biomarkers / Q000032:analysis; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000178:diet therapy / Q000201:enzymology / Q000276:immunology*; D003874:Dermatitis Herpetiformis / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology*; D055050:Diet, Gluten-Free; D005260:Female; D019204:GTP-Binding Proteins; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D007421:Intestine, Small / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins