title: Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
abstract: The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case-control studies were collected; odds ratios (ORs) with 95% confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95% CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95% CI = 1.03-1.25, P = 0.014, P(heterogeneity) = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95% CI = 1.06-1.60, P = 0.013, P heterogeneity = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95% CI = 1.05-1.46, P = 0.013, P(heterogeneity) = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.
authors.affiliation: Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hu
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Hu
authors.forename: Long-Chuan
authors.initials: LC
authors.lastname: Xie
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Xu
authors.forename: Ming-Yue
authors.initials: MY
authors.lastname: Wu
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1