title: Triazoles: a valuable insight into recent developments and biological activities.
abstract: In recent years, heterocyclic compounds, analogs, and derivatives have attracted strong interest due to their useful biological and pharmacological properties. The small and simple triazole nucleus is present in compounds aimed at evaluating new entities that possess anti-microbial, anti-tumor, antitubercular, anti-convulsant, anti-depressant, antimalarial, and anti-inflammatory activities. Triazoles display a broad range of biological activities and are found in many potent, biologically active compounds, such as trazodone (antidepressant drug), rizatriptan (antimigrane drug), hexaconazole (antifungal drug) and alprazolam (hyptonic, sedative and tranquilizer drug). So far, modifications of the triazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized triazoles possessing important biological activities.
authors.affiliation: Institute of Professional Studies College of Pharmacy, Gwalior 474001, India. Electronic address: jagdish.Pharmacist@gmail.com.
authors.forename: Jagdish K
authors.initials: JK
authors.lastname: Sahu
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835215, India.
authors.forename: Swastika
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: Institute of Professional Studies College of Pharmacy, Gwalior 474001, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Kaushik
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D014230:Triazoles
keywords: Anti-inflammatory; Anticancer; Anticonvulsant; Antidepressant; Antifungal; Antimalarial; Antitubercular; Antiviral; Triazoles