title: Clinical activity and tolerability of a 14-day infusional Ifosfamide schedule in soft-tissue sarcoma.
abstract: Background. Soft-tissue sarcomas (STS) are a heterogeneous group of diseases with lack of effective treatments in most cases. Previous data suggest that continuous infusional ifosfamide regimens might improve cytotoxicity and tolerability compared to standard schedules. Methods. We retrospectively report the outcome of 35 patients affected by STS treated with a 14-day infusional ifosfamide regimen (1000 mg/m(2)/day) in our institution. Predictive factors for toxicity were also explored. Results. Median age was 53 years. There were 16 males and 19 females. Classification by histology was dedifferentiated liposarcoma (DDLPS): 22 (62.8%), synovial sarcoma: 7 (20%), myxoid/round-cell liposarcoma: 3 (8.5%), and others: 3 (8.5%). Overall, 7 patients (20%) achieved partial response (PR) and 10 patients (29%) achieved stable disease (SD). DDLPS showed special sensitivity: 5 patients (22.7%) had PR, 7 patients (31.8%) had SD, and disease control rate was 54.5%. Median progression-free survival and overall survival were 4.2 and 11.2 months, respectively. The most common toxicities were fatigue, nausea, and vomiting (all grades: 85.7%, 83%, and 54.3%, resp.). Neither hypoalbuminaemia nor gender was found to predict toxicity, although encephalopathy predominantly affected females. Conclusion. Ifosfamide administered as a 14-day continuous infusion is a safe regimen in STS with notable activity in DDLPS.
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Juan
authors.initials: J
authors.lastname: Martin-Liberal
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Salma
authors.initials: S
authors.lastname: Alam
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Constantinidou
authors.affiliation: Department of Histopathology, The Royal Marsden Hospital, Fulham Road , London SW3 6JJ, UK.
authors.forename: Cyril
authors.initials: C
authors.lastname: Fisher
authors.affiliation: Department of Statistics, The Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK.
authors.forename: Komel
authors.initials: K
authors.lastname: Khabra
authors.affiliation: Department of Radiodiagnostics, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Christina
authors.initials: C
authors.lastname: Messiou
authors.affiliation: Spanish National Cancer Research Centre (CNIO), Clinical Research Programme, 3 Melchor Fernandez Almagro, 28029 Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Olmos
authors.affiliation: Department of Pharmacy, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Scott
authors.initials: S
authors.lastname: Mitchell
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Omar
authors.initials: O
authors.lastname: Al-Muderis
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Aisha
authors.initials: A
authors.lastname: Miah
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Linch
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Jones
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Scurr
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Judson
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Benson