title: Bronchoalveolar lavage fluid and serum canine surfactant protein A concentrations in dogs with chronic cough by bronchial and interstitial lung diseases.
abstract: We measured bronchoalveolar lavage fluid (BALF) and serum canine surfactant protein (cSP)-A concentrations in dogs with chronic cough. There were no significant differences between bronchial and interstitial lung diseases in BALF cSP-A concentrations. However, serum cSP-A concentrations in dogs with the interstitial lung disease as diffuse panbronchiolitis and idiopathic pulmonary fibrosis were significantly higher than those in dogs with the bronchial disease as chronic bronchitis. These results suggest that serum cSP-A concentrations may be a useful and noninvasive biomarker to understand the existence of interstitial lung damage in dogs with chronic cough.
authors.affiliation: Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaya
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Watari
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D001982:Bronchial Diseases / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D003371:Cough / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D037662:Pulmonary Surfactant-Associated Protein A