title: Regiodivergent heterocyclization: a strategy for the synthesis of substituted pyrroles and furans using α-formyl ketene dithioacetals as common precursors.
abstract: The selective construction of a diverse array of five-membered aromatic heterocycles from common starting materials is an attractive and challenging task. We report here that 5-alkylthio-pyrroles, 4-alkylthiocarbonyl-pyrroles and 2-alkylthio-4-tosyl-furans can be prepared, selectively, in a single operation using the readily available α-formyl ketene dithioacetals as common precursors, through their regiodivergent heterocyclization with α-acidic isocyanides controlled by the choice of suitable catalysts/promoters.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China. panl948@nenu.edu.cn liuqun@nenu.edu.cn.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu