title: Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives.
abstract: Seventeen new derivatives of betulinic acid (BA) with potential anti-tumor activity have been synthesized. In order to improve the bioactivity of BA, we connected BA and nitric oxide donors together via different linkers. The results of the biological activity of these derivatives showed that four compounds exhibited obvious cytotoxicity against human hepatocellular carcinoma cells in vitro.
authors.affiliation: a Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , 210009 , P.R. China.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Jia
authors.initials: J
authors.lastname: Tang
authors.forename: Zi-Fei
authors.initials: ZF
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D008113:Liver Neoplasms; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D009569:Nitric Oxide; D000094062:Betulinic Acid