title: [Comparison of clinical outcome of mild-stimulation and conventional ovarian stimulation in in vitro fertilization-embryo transfer (IVF-ET)].
abstract: OBJECTIVE
  To investigate the practical application value of the mild-stimulation method used in in vitro fertilization and embryo transfer (IVF-ET) treatment for IVF patients with normal ovarian function.
  
  
  METHODS
  The patients (ages from 26 to 38 years) with normal ovarian function, who were treated with IVF-ET in Affiliated Reproductive Center of China Medical University from January 2004 to July 2012 were selected as our samples. We compared the clinical results of treatment between the mild-stimulation (104 cycles in experimental group) and the conventional stimulation (198 cycles in control group).
  
  
  RESULTS
  The number of retrieved oocytes (3.1±1.6 vs. 10.2±5.7, P<0.05) and clinical pregnancy rate [34% (33/97) vs. 49.7% (93/187), P<0.05] of the mild-stimulation group (104 cycles) were lower than those of the control group (198 cycles), however, the duration of stimulation (4.7±2.1 vs. 9.16±1.87) and total doses of 75 U gonadotropins used (5.7±3.7 vs. 30.9±10.3) were also lower in the mild-stimulation group than in the control group obviously (P<0.05).
  
  
  CONCLUSIONS
  For the normal ovarian function patients, the mild-stimulation method has clear clinical effects, but not as good as the conventional-stimulation one.
authors.affiliation: Assisted Reproduction Center, Shengjing Hospital of China Medical University, Shenyang 110004, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shen
authors.forename: Yi-xian
authors.initials: YX
authors.lastname: Wang
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.forename: Xiu-xia
authors.initials: XX
authors.lastname: Wang
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006062:Gonadotropins; D002996:Clomiphene