title: Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome.
abstract: Acute respiratory distress syndrome (ARDS) is the most severe form of lung injury, characterised by alveolar oedema and vascular permeability, in part due to disruption of the alveolar capillary membrane integrity. Vascular endothelial growth factor (VEGF) was originally identified as a vascular permeability factor and has been implicated in the pathogenesis of acute lung injury/ARDS. This review describes our current knowledge of VEGF biology and summarises the literature investigating the potential role VEGF may play in normal lung maintenance and in the development of lung injury.
authors.affiliation: Academic Respiratory Unit, University of Bristol, Bristol, UK.
authors.forename: S
authors.initials: S
authors.lastname: Barratt
authors.forename: A R
authors.initials: AR
authors.lastname: Medford
authors.forename: A B
authors.initials: AB
authors.lastname: Millar
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology*; D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism; D039942:Neuropilin-1 / Q000378:metabolism; D039943:Neuropilin-2 / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D039943:Neuropilin-2; D042461:Vascular Endothelial Growth Factor A; D039942:Neuropilin-1; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2