title: Sequential catalysis for stereoselective synthesis of complex polyketides.
abstract: This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophilic addition and a Tsuji-Trost reaction, an innovative sequence relying on an oxidative diyne cyclization and regioselective opening, as well as sequential cross coupling strategies. The design and scope of these methods are discussed and applications in complex target syntheses presented.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, D-53121, Bonn, Germany. dirk.menche@uni-bonn.de.
authors.forename: Daniel
authors.initials: D
authors.lastname: Herkommer
authors.forename: Björn
authors.initials: B
authors.lastname: Schmalzbauer
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D061065:Polyketides