title: Bioaccessibility of Cr, Cu, Fe, Mg, Mn, Mo, Se and Zn from nutritional supplements by the unified BARGE method.
abstract: In this study, the Unified Bioaccessibility Research Group of Europe (BARGE) in vitro method was used to assess the bioaccessibility of Cr, Cu, Fe, Mg, Mn, Mo, Se, and Zn in ten nutritional supplement samples and three certified reference materials. The total digest, gastric phase and gastro-intestinal phase concentrations of Cu, Fe, Mg, Mn and Zn were determined by ICP-OES and Cr, Mo and Se by ICP-MS. The bioaccessible fractions of the elements in the gastric phase for the nutritional supplements were in the range 13-89% for Cr, 9-79% for Cu, 55-99% for Fe, 33-95% for Mg, 83-94% for Mn, 42-101% for Mo, 74-125% for Se and 81-104% for Zn. The range for the gastrointestinal phase was 6-65% for Cr, 27-66% for Cu, 3-14% for Fe, 34-91% for Mg, 53-62% for Mn, 40-109% for Mo, 53-146% for Se and 3-35% for Zn.
authors.affiliation: Erciyes University, Faculty of Science, Chemistry Department, TR 38039 Kayseri, Turkey. Electronic address: serifet@erciyes.edu.tr.
authors.forename: Serife
authors.initials: S
authors.lastname: Tokalıoğlu
authors.affiliation: School of Geography, Earth and Environmental Sciences, Plymouth University, Drake Circus, Plymouth, Devon PL4 8AA, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Clough
authors.affiliation: School of Geography, Earth and Environmental Sciences, Plymouth University, Drake Circus, Plymouth, Devon PL4 8AA, UK.
authors.forename: Mike
authors.initials: M
authors.lastname: Foulkes
authors.affiliation: School of Geography, Earth and Environmental Sciences, Plymouth University, Drake Circus, Plymouth, Devon PL4 8AA, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Worsfold
mesh_terms: D001682:Biological Availability; D019587:Dietary Supplements / Q000032:analysis*; D005060:Europe; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D019216:Metals, Heavy / Q000032:analysis / Q000493:pharmacokinetics; D008954:Models, Biological; D012643:Selenium / Q000032:analysis / Q000493:pharmacokinetics; D014131:Trace Elements / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D019216:Metals, Heavy; D014131:Trace Elements; D012643:Selenium
keywords: BARGE method; Bioaccessibility; ICP-MS; ICP-OES; Nutritional supplement