title: Propanil-induced histopathological changes in the liver and kidney of mice.
abstract: OBJECTIVE
  To examine sublethal toxic effects of propanil on liver and kidney of albino Swiss mice, Mus musculus.
  
  
  METHODS
  Different doses of propanil (75, 150, and 300 mg/kg) were administered to determine histologic defects on liver and kidney tissues of mice for 30 consecutive days. Biometric analyses (area measurements of hepatocyte/nucleus and glomerulus/renal corpuscle) were also conducted to determine whether there were statistical differences in these end points.
  
  
  RESULTS
  Cloudy swelling, cytoplasmic vacuolization, nuclear degeneration, nucleus loss, mononuclear cell infiltration, congestion, enlargement of the sinusoids, and increases in the number of Kupffer cells were prominent in the liver of exposed mice. In kidney tissue mononuclear cell infiltration, glomerular degeneration, glomerular loss, and congestion were determined in propanil-treated groups.
  
  
  CONCLUSIONS
  Propanil induced dose-dependent histopathological changes in the liver and kidney tissues of exposed mice. This study showed that propanil exposure might cause harmful effects to nontarget organisms, including humans.
authors.affiliation: Zoology Section, Biology Department, Science Faculty, Ege University, Bornova-Izmir, Turkey. ozlem.cakici@ege.edu.tr
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cakici
authors.affiliation: Zoology Section, Biology Department, Science Faculty, Ege University, Bornova-Izmir, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Akat
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D004305:Dose-Response Relationship, Drug; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D011411:Propanil / Q000633:toxicity*
chemical_list: D011411:Propanil