title: To grow or not to grow: hair morphogenesis and human genetic hair disorders.
abstract: Mouse models have greatly helped in elucidating the molecular mechanisms involved in hair formation and regeneration. Recent publications have reviewed the genes involved in mouse hair development based on the phenotype of transgenic, knockout and mutant animal models. While much of this information has been instrumental in determining molecular aspects of human hair development and cycling, mice exhibit a specific pattern of hair morphogenesis and hair distribution throughout the body that cannot be directly correlated to human hair. In this mini-review, we discuss specific aspects of human hair follicle development and present an up-to-date summary of human genetic disorders associated with abnormalities in hair follicle morphogenesis, structure or regeneration.
authors.affiliation: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, United States. Electronic address: duvergero@mail.nih.gov.
authors.forename: Olivier
authors.initials: O
authors.lastname: Duverger
authors.affiliation: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, United States. Electronic address: morasso@nih.gov.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Morasso
mesh_terms: D000505:Alopecia / Q000235:genetics / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006197:Hair / Q000002:abnormalities* / Q000254:growth & development* / Q000473:pathology; D006201:Hair Diseases / Q000235:genetics* / Q000473:pathology*; D018859:Hair Follicle / Q000002:abnormalities* / Q000254:growth & development* / Q000473:pathology; D006801:Humans; D051379:Mice; D009024:Morphogenesis
keywords: Alopecia; Genetic disorders; Hair follicle; Morphogenesis; Shaft differentiation