title: TRP channels in the skin.
abstract: Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities.
authors.affiliation: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; DE-MTA 'Lendület' Cellular Physiology Research Group, Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Debrecen, Hungary.
authors.forename: Balázs I
authors.initials: BI
authors.lastname: Tóth
authors.forename: Attila
authors.initials: A
authors.lastname: Oláh
authors.forename: Attila Gábor
authors.initials: AG
authors.lastname: Szöllősi
authors.forename: Tamás
authors.initials: T
authors.lastname: Bíró
mesh_terms: D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology; D006801:Humans; D049990:Membrane Transport Modulators / Q000494:pharmacology; D015398:Signal Transduction; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012871:Skin Diseases / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000378:metabolism*
chemical_list: D003879:Dermatologic Agents; D049990:Membrane Transport Modulators; D050051:Transient Receptor Potential Channels
keywords: atopic dermatitis; barrier; differentiation; inflammation; skin; transient receptor potential (TRP) channels