title: An intravascular large B-cell lymphoma with a t(3;14)(q27;q32) translocation.
abstract: A 61-year-old man with no symptom was found with bilateral adrenal nodules on CT scan during a routine physical check-up. The left nodule was removed by adrenalectomy, and the patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL) on pathological and immunohistochemical examinations. Using a set of dual-colour, break-apart probes and fluorescence in situ hybridisation, it was revealed that the lymphoma cells have tetraploid karyotype, with a breakpoint in BCL6 gene, which was further confirmed as a t(3;14)(q27;q32) translocation. To the best of our knowledge, this is the first report of IVLBCL with such a translocation.
authors.affiliation: Department of Pathology, Qianfoshan Hospital Affiliated with Shandong University, , Jinan, Shandong Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Cheng
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D000315:Adrenalectomy; D056905:Chromosome Breakpoints; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D033162:Incidental Findings; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6; D014178:Translocation, Genetic; D019043:Vascular Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6
keywords: ADRENAL GLAND; HAEMATOPATHOLOGY; LYMPHOMA