title: Topical immunotherapy with diphenylcyclopropenone is effective and preferred in the treatment of periungual warts.
abstract: BACKGROUND
  There exists a treatment challenge with periungual warts. Topical immunotherapy with diphenylcyclopropenone (DPCP) has recently been reported to be an effective treatment for recalcitrant warts, including periungual types.
  
  
  OBJECTIVE
  We aimed to evaluate the effectiveness and preference of topical immunotherapy with DPCP in treating periungual warts.
  
  
  METHODS
  Twenty-seven patients with periungual warts who were treated with DPCP immunotherapy (2007 through 2010; Dongguk University Ilsan Hospital, Goyang, Korea) were retrospectively recruited. Other treatment modalities were also used in some patients. Lesions were grouped into the types according to the following locations: proximal nail fold, lateral nail fold and hyponychium. Total and group clearance rates as well as treatment periods according to location and disease duration were evaluated. A patient questionnaire was performed to assess the satisfaction for the treatments in those who received multiple therapies.
  
  
  RESULTS
  Total success rates were 85% (by subjects) and 91% (by individual lesions). Success rate and treatment period for proximal nail fold type seemed more desirable than other locations. Success rate decreased and treatment period increased as disease duration increased. The questionnaire revealed a significantly higher satisfaction rate for DPCP immunotherapy than for cryotherapy and pulsed-dye laser.
  
  
  CONCLUSIONS
  Topical immunotherapy with DPCP is an effective and preferred method in the treatment of periungual warts.
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
authors.forename: Yunseok
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
authors.forename: Do Hun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
authors.forename: Sang Yun
authors.initials: SY
authors.lastname: Jin
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
authors.forename: Ai-Young
authors.initials: AY
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
keywords: Diphenylcyclopropenone; Immunotherapy; Periungual wart; Therapy