title: Rationale for stereotactic body radiation therapy in treating patients with oligometastatic hormone-naïve prostate cancer.
abstract: Despite advances in treatment for metastatic prostate cancer, patients eventually progress to castrate-resistant disease and ultimately succumb to their cancer. Androgen deprivation therapy (ADT) is the standard treatment for metastatic prostate cancer and has been shown to improve median time to progression and median survival time. Research suggests that castrate-resistant clones may be present early in the disease process prior to the initiation of ADT. These clones are not susceptible to ADT and may even flourish when androgen-responsive clones are depleted. Stereotactic body radiation therapy (SBRT) is a safe and efficacious method of treating clinically localized prostate cancer and metastases. In patients with a limited number of metastatic sites, SBRT may have a role in eliminating castrate-resistant clones and possibly delaying progression to castrate-resistant disease.
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Onita
authors.initials: O
authors.lastname: Bhattasali
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Leonard N
authors.initials: LN
authors.lastname: Chen
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Tong
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Lei
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Collins
authors.affiliation: Department of Radiology, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Pranay
authors.initials: P
authors.lastname: Krishnan
authors.affiliation: Department of Neurosurgery, Georgetown University Medical Center , Washington, DC , USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kalhorn
authors.affiliation: Department of Urology, Georgetown University Hospital , Washington, DC , USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Lynch
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Simeng
authors.initials: S
authors.lastname: Suy
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Anatoly
authors.initials: A
authors.lastname: Dritschilo
authors.affiliation: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center , Washington, DC , USA.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Dawson
authors.affiliation: Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , USA.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Collins
keywords: IGRT; SBRT; cyberknife; hormone-naïve; oligometastases; prostate cancer