title: Influence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic molecule.
abstract: In this work, we studied the effect of nanoliposome composition based on phospholipids of docosahexaenoic acid (PL-DHA), salmon and soya lecithin, on physico-chemical characterization of vector. Cinnamic acid was encapsulated as a hydrophobic molecule in nanoliposomes made of three different lipid sources. The aim was to evaluate the influence of membrane lipid structure and composition on entrapment efficiency and membrane permeability of cinnamic acid. These properties are important for active molecule delivery. In addition, size, electrophoretic mobility, phase transition temperature, elasticity and membrane fluidity were measured before and after encapsulation. The results showed a correlation between the size of the nanoliposome and the entrapment. The entrapment efficiency of cinnamic acid was found to be the highest in liposomes prepared from salmon lecithin. The nanoliposomes composed of salmon lecithin presented higher capabilities as a carrier for cinnamic acid encapsulation. These vesicles also showed a high stability which in turn increases the membrane rigidity of nanoliposome as evaluated by their elastic properties, membrane fluidity and phase transition temperature.
authors.affiliation: Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France.
authors.forename: Lynda
authors.initials: L
authors.lastname: Bouarab
authors.affiliation: Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France.
authors.forename: Behnoush
authors.initials: B
authors.lastname: Maherani
authors.affiliation: Department of Biomedical Engineering, University of California, 451 East Health Sciences Drive, Davis, CA 95616, USA.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Kheirolomoom
authors.affiliation: Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hasan
authors.affiliation: Department of Civil, Chemical and Environmental Engineering (DICCA), University of Genoa, Via Opera Pia 15, 16145 Genova, Italy.
authors.forename: Bahar
authors.initials: B
authors.lastname: Aliakbarian
authors.affiliation: Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Linder
authors.affiliation: Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France. Electronic address: elmira.arab-tehrany@univ-lorraine.fr.
authors.forename: Elmira
authors.initials: E
authors.lastname: Arab-Tehrany
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D002849:Chromatography, Gas; D002934:Cinnamates / Q000737:chemistry; D004281:Docosahexaenoic Acids / Q000737:chemistry; D055119:Elastic Modulus; D004586:Electrophoresis; D057927:Hydrophobic and Hydrophilic Interactions; D054709:Lecithins / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry* / Q000648:ultrastructure; D008560:Membrane Fluidity; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D044367:Phase Transition; D012212:Rheology; D012474:Salmon; D012995:Solubility; D013696:Temperature; D014783:Viscosity
chemical_list: D002934:Cinnamates; D054709:Lecithins; D008081:Liposomes; C029010:cinnamic acid; D004281:Docosahexaenoic Acids
keywords: Antioxidant; Cinnamic acid; Encapsulation; Liposome; Physico-chemical characterization