title: Kaposi sarcoma in a patient with chronic renal failure undergoing dialysis.
abstract: Kaposi sarcoma (KS) is a multicentric proliferative vascular tumor involving the skin and other organs. Human herpesvirus 8 (HHV-8) has been detected in KS lesions and is considered the putative causative agent of KS. The relationship between chronic renal failure, HHV-8, and KS is not clear. KS appears to develop in association with renal transplantation, but is unlikely with dialysis, and there have been few reports on this. Here, we report the case of a 51-year-old man, who underwent peritoneal dialysis to treat chronic renal failure, and presented with multiple brownish plaques on his soles. On histopathological examination, abnormally proliferated vessels, vascular slits, and spindle-shaped cells were seen in the dermis. Immunohistochemical staining for HHV-8 was positive. This case is another example in which factors other than immunosuppression contributed to the development of KS, due to activation of HHV-8.
authors.affiliation: Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Deborah
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Ji-Sung
authors.initials: JS
authors.lastname: Chun
authors.affiliation: Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Soon-Kwon
authors.initials: SK
authors.lastname: Hong
authors.affiliation: Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Mi-Seon
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Seo
authors.affiliation: Department of Dermatology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Jae-Kyoung
authors.initials: JK
authors.lastname: Koh
authors.affiliation: Department of Dermatology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Ho-Suk
authors.initials: HS
authors.lastname: Sung
keywords: Chronic kidney failure; Dialysis; Human herpesvirus 8; Kaposi sarcoma