title: The 5-HT3A receptor is essential for fear extinction.
abstract: The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.
authors.affiliation: Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kondo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ishida
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamada
authors.forename: Shoichi
authors.initials: S
authors.lastname: Shimada
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism; D003214:Conditioning, Classical / Q000502:physiology; D004597:Electroshock / Q000009:adverse effects; D005108:Extinction, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D044406:Receptors, Serotonin, 5-HT3 / Q000172:deficiency / Q000502:physiology*
chemical_list: D044406:Receptors, Serotonin, 5-HT3